Search of human proteins with 4506115

Search of human proteins with 4506115

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506115 protein C [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506115 protein C [Homo sapiens]                                   982   0.0  
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   312   4e-85
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          311   8e-85
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   311   1e-84
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         284   1e-76
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         179   5e-45
gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [H...   178   8e-45
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           170   3e-42
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             159   5e-39
gi|4504383 HGF activator preproprotein [Homo sapiens]                 157   1e-38
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  155   7e-38
gi|4503627 coagulation factor XI precursor [Homo sapiens]             155   9e-38
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   153   3e-37
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]            153   4e-37
gi|91823048 kallikrein 14 preproprotein [Homo sapiens]                152   8e-37
gi|4506143 neurotrypsin precursor [Homo sapiens]                      152   8e-37
gi|4503137 chymotrypsin-like [Homo sapiens]                           152   8e-37
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   151   1e-36
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   151   1e-36
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          147   2e-35
gi|61744424 kallikrein-related peptidase 6 isoform A preproprote...   147   2e-35
gi|4506155 kallikrein-related peptidase 6 isoform A preproprotei...   147   2e-35
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    147   3e-35
gi|117956391 protease, serine, 33 [Homo sapiens]                      146   4e-35
gi|4505881 plasminogen [Homo sapiens]                                 145   8e-35
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]     144   1e-34
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]          144   1e-34
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]       144   1e-34
gi|4506153 prostasin preproprotein [Homo sapiens]                     144   1e-34
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           144   2e-34

>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  982 bits (2538), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI 60
           MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI
Sbjct: 1   MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI 60

Query: 61  EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC 120
           EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC
Sbjct: 61  EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC 120

Query: 121 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK 180
           DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK
Sbjct: 121 DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK 180

Query: 181 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA 240
           FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA
Sbjct: 181 FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA 240

Query: 241 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI 300
           VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI
Sbjct: 241 VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI 300

Query: 301 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL 360
           ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL
Sbjct: 301 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL 360

Query: 361 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV 420
           NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV
Sbjct: 361 NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV 420

Query: 421 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP 461
           SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
Sbjct: 421 SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP 461


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  312 bits (800), Expect = 4e-85
 Identities = 174/448 (38%), Positives = 253/448 (56%), Gaps = 36/448 (8%)

Query: 18  GTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVD 77
           G    L +VF + E AH VL  R+RAN+FLEELR  SLEREC EE C FEEA+EIF++ +
Sbjct: 14  GLQGCLAAVFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAE 73

Query: 78  DTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQ-REVS 136
            T  FW  + DGDQC   P        C   G+C D + S+ C C   +EGR C+  +  
Sbjct: 74  RTKLFWISYSDGDQCASSP--------CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDD 125

Query: 137 FLNCSLDNGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRS 195
            L C  +NGGC  YC +  G +R C C  GY L  D + C P V++PCG+    +EK+ +
Sbjct: 126 QLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKI-PILEKRNA 184

Query: 196 HLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCM 255
                      +   R++ GK+  +G+ PWQV+LL +  +L CG  LI+  WV++AAHC 
Sbjct: 185 ----------SKPQGRIVGGKVCPKGECPWQVLLLVNGAQL-CGGTLINTIWVVSAAHCF 233

Query: 256 DESKK---LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLS 312
           D+ K    L+  LGE+DL   +  E    + +V +   Y   TT++DIALL L QP  L+
Sbjct: 234 DKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLT 293

Query: 313 QTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNE 372
             +VP+CLP+   +ER L    + +LV+GWG    R   A       L  + +P +   +
Sbjct: 294 DHVVPLCLPERTFSERTLAFV-RFSLVSGWGQLLDRGATALE-----LMVLNVPRLMTQD 347

Query: 373 CSEVMSNM-----VSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCG 427
           C +    +     ++E M CAG     +D+C+GDSGGP    + GTW+L G+VSWG+GC 
Sbjct: 348 CLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCA 407

Query: 428 LLHNYGVYTKVSRYLDWIHGHIRDKEAP 455
            + ++GVYT+VS+Y++W+   +R +  P
Sbjct: 408 TVGHFGVYTRVSQYIEWLQKLMRSEPRP 435


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  311 bits (797), Expect = 8e-85
 Identities = 167/475 (35%), Positives = 259/475 (54%), Gaps = 54/475 (11%)

Query: 24  DSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFW 83
           +S+F   E+A+ +L    RANSFLEE++   LEREC+EE C +EEA+E+F++ D T  FW
Sbjct: 22  ESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFW 81

Query: 84  SKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLD 143
           +K+ DGDQC   P        C   G C DG+G ++C C  G+EG+ C+     L CSLD
Sbjct: 82  NKYKDGDQCETSP--------CQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKL-CSLD 132

Query: 144 NGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTED 203
           NG C  +C EE     CSCA GY L D+   C P   +PCG+  + +E+++  + + T  
Sbjct: 133 NGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGK--QTLERRKRSVAQATSS 190

Query: 204 QED-------------QVDP-----------------------RLIDGKMTRRGDSPWQV 227
             +              +DP                       R++ G+  + G+ PWQ 
Sbjct: 191 SGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQA 250

Query: 228 VLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFV 287
           +L++ + +  CG  ++   ++LTAAHC+ ++K+  VR+G+ +  + E  E   +++ V  
Sbjct: 251 LLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIK 310

Query: 288 HPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSS 347
           H  ++K T D DIA+L L  P T    + P CLP+   AE  L    +  +V+G+G    
Sbjct: 311 HNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTL-MTQKTGIVSGFGRTHE 369

Query: 348 REKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMV 407
           + +++ R     L  +++P V  N C    S ++++NM CAG    ++DAC+GDSGGP V
Sbjct: 370 KGRQSTR-----LKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHV 424

Query: 408 ASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQ-KSWAP 461
             F  T+F+ G+VSWGEGC     YG+YTKV+ +L WI   ++ +  P+ KS AP
Sbjct: 425 TRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAP 479


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  311 bits (796), Expect = 1e-84
 Identities = 172/440 (39%), Positives = 250/440 (56%), Gaps = 36/440 (8%)

Query: 26  VFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSK 85
           VF + E AH VL  R+RAN+FLEELR  SLEREC EE C FEEA+EIF++ + T  FW  
Sbjct: 44  VFVTQEEAHGVLHRRRRANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWIS 103

Query: 86  HVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQ-REVSFLNCSLDN 144
           + DGDQC   P        C   G+C D + S+ C C   +EGR C+  +   L C  +N
Sbjct: 104 YSDGDQCASSP--------CQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNEN 155

Query: 145 GGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTED 203
           GGC  YC +  G +R C C  GY L  D + C P V++PCG+    +EK+ +        
Sbjct: 156 GGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKI-PILEKRNA-------- 206

Query: 204 QEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK--- 260
              +   R++ GK+  +G+ PWQV+LL +  +L CG  LI+  WV++AAHC D+ K    
Sbjct: 207 --SKPQGRIVGGKVCPKGECPWQVLLLVNGAQL-CGGTLINTIWVVSAAHCFDKIKNWRN 263

Query: 261 LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICL 320
           L+  LGE+DL   +  E    + +V +   Y   TT++DIALL L QP  L+  +VP+CL
Sbjct: 264 LIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTNHDIALLRLHQPVVLTDHVVPLCL 323

Query: 321 PDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNM 380
           P+   +ER L    + +LV+GWG    R   A       L  + +P +   +C +    +
Sbjct: 324 PERTFSERTLAFV-RFSLVSGWGQLLDRGATALE-----LMVLNVPRLMTQDCLQQSRKV 377

Query: 381 -----VSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVY 435
                ++E M CAG     +D+C+GDSGGP    + GTW+L G+VSWG+GC  + ++GVY
Sbjct: 378 GDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQGCATVGHFGVY 437

Query: 436 TKVSRYLDWIHGHIRDKEAP 455
           T+VS+Y++W+   +R +  P
Sbjct: 438 TRVSQYIEWLQKLMRSEPRP 457


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  284 bits (727), Expect = 1e-76
 Identities = 159/447 (35%), Positives = 235/447 (52%), Gaps = 47/447 (10%)

Query: 25  SVFSSSERAHQVLRIRKRANSF-LEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFW 83
           +VF   E A+++L   KR NS  LEE    +LEREC+EE C FEEA+E+F+N + T  FW
Sbjct: 29  TVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFW 88

Query: 84  SKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLD 143
            ++VDGDQC   P        C   G+C D I S+ C C  G+EG+ C+ +V+   C++ 
Sbjct: 89  KQYVDGDQCESNP--------CLNGGSCKDDINSYECWCPFGFEGKNCELDVT---CNIK 137

Query: 144 NGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKR--- 199
           NG C  +C      +  CSC  GY+L ++   C PAV FPCGR       K +  +    
Sbjct: 138 NGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFP 197

Query: 200 -----DTEDQEDQVD------------PRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVL 242
                ++ + E  +D             R++ G+  + G  PWQVVL + K    CG  +
Sbjct: 198 DVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSI 256

Query: 243 IHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTT--DNDI 300
           ++  W++TAAHC++   K+ V  GE+++   E  E   ++  +  H NY+ +    ++DI
Sbjct: 257 VNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDI 316

Query: 301 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG--YHSSREKEAKRNRTF 358
           ALL L +P  L+  + PIC+ D       L        V+GWG  +H  R          
Sbjct: 317 ALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSG--YVSGWGRVFHKGRS-------AL 367

Query: 359 VLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVG 418
           VL ++++P+V    C       +  NM CAG     +D+C+GDSGGP V    GT FL G
Sbjct: 368 VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTG 427

Query: 419 LVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           ++SWGE C +   YG+YTKVSRY++WI
Sbjct: 428 IISWGEECAMKGKYGIYTKVSRYVNWI 454


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  179 bits (454), Expect = 5e-45
 Identities = 108/272 (39%), Positives = 151/272 (55%), Gaps = 18/272 (6%)

Query: 191 EKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLL-DSKKKLACGAVLIHPSWVL 249
           EKK    K + E  E  +D R+++G     G SPWQV+L   S ++L CGA LI   WVL
Sbjct: 343 EKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVL 402

Query: 250 TAAHCM-----DES---KKLLVRLGEYDLRRWEK-WELDLDIKEVFVHPNYS-KSTTDND 299
           TAAHC+     D++     LLVR+G++   R+E+  E    ++++++HP Y+ +   D D
Sbjct: 403 TAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRD 462

Query: 300 IALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG-YHSSREKEAKRNRTF 358
           IAL+ L +P   S  I P+CLPD   A   L QAG +  VTGWG    +      + +  
Sbjct: 463 IALMKLKKPVAFSDYIHPVCLPDRETAA-SLLQAGYKGRVTGWGNLKETWTANVGKGQPS 521

Query: 359 VLNFIKIPVVPHNECSEVMSNMVSENMLCAGIL---GDRQDACEGDSGGPMV--ASFHGT 413
           VL  + +P+V    C +     +++NM CAG     G R DACEGDSGGP V  + F+  
Sbjct: 522 VLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNR 581

Query: 414 WFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           W+ +G+VSWGEGC     YG YT V R   WI
Sbjct: 582 WYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI 613



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 35/92 (38%), Positives = 55/92 (59%), Gaps = 4/92 (4%)

Query: 26  VFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSK 85
           VF + ++A  +L+  +RAN+FLEE+R  +LEREC+EE C +EEA E  ++   T  FW+K
Sbjct: 27  VFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAK 86

Query: 86  HVDGDQCLVLPLEHPCASLCCGHGTCIDGIGS 117
           +   +     P +   A   C  G C +G+G+
Sbjct: 87  YTACETART-PRDKLAA---CLEGNCAEGLGT 114


>gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [Homo
           sapiens]
          Length = 400

 Score =  178 bits (452), Expect = 8e-45
 Identities = 135/425 (31%), Positives = 193/425 (45%), Gaps = 58/425 (13%)

Query: 25  SVFSSSERAHQVLRIRKRANSFL-EELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFW 83
           SVF  + +A+ VL   KRA S+L EEL   +LE+EC EEIC +EEA+E+F+N   T  FW
Sbjct: 23  SVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVYEEAREVFENEVVTDEFW 82

Query: 84  SKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLD 143
            ++  G  C+  P        C  +G+C D I  ++C C  G+EG  C  E++   C  +
Sbjct: 83  RRYKGGSPCISQP--------CLHNGSCQDSIWGYTCTCSPGYEGSNC--ELAKNECHPE 132

Query: 144 -NGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTE 202
              GC H+CL       CSCA GY+LG+D  QC P  +  CG      EK+   L+    
Sbjct: 133 RTDGCQHFCLPGQESYTCSCAQGYRLGEDHKQCVPHDQCACG--VLTSEKRAPDLQ---- 186

Query: 203 DQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLL 262
                              D PWQV L +S+ K  CG V+I  ++VLT A C    + + 
Sbjct: 187 -------------------DLPWQVKLTNSEGKDFCGGVIIRENFVLTTAKCSLLHRNIT 227

Query: 263 VRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPD 322
           V+       R  +  L + I  V VH  Y     +ND++LL L  P       +P+C P+
Sbjct: 228 VKT---YFNRTSQDPLMIKITHVHVHMRYDADAGENDLSLLELEWPIQCPGAGLPVCTPE 284

Query: 323 SGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFI---KIPVVPHNECSEVMSN 379
              AE  L       L++GW           RN T + N +    + +V   EC +V++ 
Sbjct: 285 KDFAEHLLIPR-TRGLLSGWA----------RNGTDLGNSLTTRPVTLVEGEECGQVLNV 333

Query: 380 MVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVS 439
            V+    C         A     G  +     G+WFL G++      G  H   + TKVS
Sbjct: 334 TVTTRTYCE---RSSVAAMHWMDGSVVTREHRGSWFLTGVLGSQPVGGQAHMV-LVTKVS 389

Query: 440 RYLDW 444
           RY  W
Sbjct: 390 RYSLW 394


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  170 bits (430), Expect = 3e-42
 Identities = 121/371 (32%), Positives = 172/371 (46%), Gaps = 46/371 (12%)

Query: 100 PCAS--LCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGW 157
           PC    LC  +G C+        DC +G + R C    +F  C  D+   T   L +V  
Sbjct: 457 PCPGEFLCSVNGLCVPACDGVK-DCPNGLDERNCVCRATF-QCKEDS---TCISLPKV-- 509

Query: 158 RRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLK-----------RDTEDQE- 205
             C   P    G D  QC   V  PCG    + E +    K           RD  D+E 
Sbjct: 510 --CDGQPDCLNGSDEEQCQEGV--PCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEH 565

Query: 206 -----DQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK 260
                     R++ G ++  G+ PWQ  L   + +  CG  LI   WV+TAAHC  E   
Sbjct: 566 CDCGLQGPSSRIVGGAVSSEGEWPWQASL-QVRGRHICGGALIADRWVITAAHCFQEDSM 624

Query: 261 LLVRLGEYDLRR-WE--KW--ELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTI 315
               L    L + W+  +W  E+   +  + +HP + + + D D+ALL L  P   S  +
Sbjct: 625 ASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAV 684

Query: 316 VPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSE 375
            P+CLP    A     + G    +TGWG  + RE     N    L  + + ++P + CSE
Sbjct: 685 RPVCLP----ARSHFFEPGLHCWITGWG--ALREGGPISN---ALQKVDVQLIPQDLCSE 735

Query: 376 VMSNMVSENMLCAGILGDRQDACEGDSGGPMVA-SFHGTWFLVGLVSWGEGCGLLHNYGV 434
           V    V+  MLCAG    ++DAC+GDSGGP+V  +  G WFL GLVSWG GCG  + +GV
Sbjct: 736 VYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGV 795

Query: 435 YTKVSRYLDWI 445
           YT+++  + WI
Sbjct: 796 YTRITGVISWI 806


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  159 bits (402), Expect = 5e-39
 Identities = 95/242 (39%), Positives = 133/242 (54%), Gaps = 17/242 (7%)

Query: 211 RLIDGKMTRRGDSPWQVVL---LDSKKKLACGAVLIHPSWVLTAAHCMDE---SKKLLVR 264
           R++ G  +  G+ PWQV L   L +++ L CG  LI   WVLTAAHC D         + 
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHL-CGGSLIGHQWVLTAAHCFDGLPLQDVWRIY 448

Query: 265 LGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSG 324
            G  +L    K      IKE+ +H NY  S  ++DIAL+ L  P   ++   PICLP  G
Sbjct: 449 SGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKG 508

Query: 325 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNM-VSE 383
               + +       VTGWG+  S+EK   +N   +L  + IP+V + EC +   +  +++
Sbjct: 509 ----DTSTIYTNCWVTGWGF--SKEKGEIQN---ILQKVNIPLVTNEECQKRYQDYKITQ 559

Query: 384 NMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLD 443
            M+CAG     +DAC+GDSGGP+V   +G W LVG+ SWGEGC      GVYTKV+ Y+D
Sbjct: 560 RMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMD 619

Query: 444 WI 445
           WI
Sbjct: 620 WI 621


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  157 bits (398), Expect = 1e-38
 Identities = 107/322 (33%), Positives = 154/322 (47%), Gaps = 38/322 (11%)

Query: 150 YCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVD 209
           YC  E     C      +L  DLL   P    P  +   R  KKR+ L+           
Sbjct: 361 YCRLEA----CESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLR----------- 405

Query: 210 PRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESK---KLLVRLG 266
           PR+I G  +  G  PW   +        C   L+H  WV++AAHC   S     + V LG
Sbjct: 406 PRIIGGSSSLPGSHPWLAAIYIGDS--FCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLG 463

Query: 267 EYDLRRWEKWELDLDIKEVFVHPNYSK-STTDNDIALLHLAQP----ATLSQTIVPICLP 321
           ++   R         I++   +  YS  + +D+D+ L+ L +     AT SQ + PICLP
Sbjct: 464 QHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLP 523

Query: 322 DSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECS--EVMSN 379
           + G        AG +  + GWG+      E     +  L    +P+V  ++CS  EV   
Sbjct: 524 EPG----STFPAGHKCQIAGWGHLD----ENVSGYSSSLREALVPLVADHKCSSPEVYGA 575

Query: 380 MVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVS 439
            +S NMLCAG    + DAC+GDSGGP+    +G  +L G++SWG+GCG LH  GVYT+V+
Sbjct: 576 DISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVA 635

Query: 440 RYLDWIHGHIRDKEAPQKSWAP 461
            Y+DWI+  IR    P++  AP
Sbjct: 636 NYVDWINDRIR---PPRRLVAP 654



 Score = 30.0 bits (66), Expect = 4.6
 Identities = 28/98 (28%), Positives = 36/98 (36%), Gaps = 10/98 (10%)

Query: 57  RECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCL-----VLPLEHPC--ASLCCGHG 109
           ++C  E C  E   E  +  D        HV+  +C           H    +S C   G
Sbjct: 195 KDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGG 254

Query: 110 TC--IDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNG 145
           TC  I   G+  C C  G+ GR C  E     C L NG
Sbjct: 255 TCHLIVATGTTVCACPPGFAGRLCNIEPD-ERCFLGNG 291


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  155 bits (392), Expect = 7e-38
 Identities = 92/254 (36%), Positives = 130/254 (51%), Gaps = 23/254 (9%)

Query: 212 LIDGKMTRRGDSPWQVVLL--DSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYD 269
           ++ G+   R   PWQV L   D      CG  LIHP WVLTAAHC+    K L  L    
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAAL-RVQ 89

Query: 270 LRRWEKWELD--LDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
           LR    +  D  L +  + VHP +  +    DIALL L +P  +S  +  + LP +    
Sbjct: 90  LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPAS--- 146

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS--------- 378
            E    G    VTGWG     + + +    F L  +K+P++ ++ C              
Sbjct: 147 -ETFPPGMPCWVTGWG---DVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDV 202

Query: 379 NMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKV 438
            +V ++MLCAG    R+D+C+GDSGGP+V   +GTW   G+VSWGEGC   +  G+YT+V
Sbjct: 203 RIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRV 260

Query: 439 SRYLDWIHGHIRDK 452
           + YLDWIH ++  K
Sbjct: 261 TYYLDWIHHYVPKK 274


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  155 bits (391), Expect = 9e-38
 Identities = 87/245 (35%), Positives = 127/245 (51%), Gaps = 15/245 (6%)

Query: 207 QVDPRLIDGKMTRRGDSPWQVVLLDSK--KKLACGAVLIHPSWVLTAAHC---MDESKKL 261
           ++ PR++ G  + RG+ PWQV L  +   ++  CG  +I   W+LTAAHC   ++  K L
Sbjct: 383 KIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL 442

Query: 262 LVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLP 321
            V  G  +    ++      ++E+ +H  Y  + +  DIALL L      + +  PICLP
Sbjct: 443 RVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLP 502

Query: 322 DSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSE-VMSNM 380
             G    + N    +  VTGWGY   R+K         L   KIP+V + EC +    + 
Sbjct: 503 SKG----DRNVIYTDCWVTGWGYRKLRDKIQN-----TLQKAKIPLVTNEECQKRYRGHK 553

Query: 381 VSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSR 440
           ++  M+CAG     +DAC+GDSGGP+    +  W LVG+ SWGEGC      GVYT V  
Sbjct: 554 ITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVE 613

Query: 441 YLDWI 445
           Y+DWI
Sbjct: 614 YVDWI 618


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  153 bits (387), Expect = 3e-37
 Identities = 86/256 (33%), Positives = 132/256 (51%), Gaps = 33/256 (12%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDES------------ 258
           R+ +G+  ++G +PW  +L     +  CG  L+  SW++TAAHC+ +S            
Sbjct: 448 RIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLLGSSWIVTAAHCLHQSLDPEDPTLRDSD 507

Query: 259 ----KKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQT 314
                   + LG++   R ++ E  L +K   +HP Y  +T +ND+AL+ L +   L+  
Sbjct: 508 LLSPSDFKIILGKHWRLRSDENEQHLGVKHTTLHPQYDPNTFENDVALVELLESPVLNAF 567

Query: 315 IVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECS 374
           ++PICLP+         Q G   +V+GWG      K+  +     L  I+IP+V H+ C 
Sbjct: 568 VMPICLPEGP------QQEGAMVIVSGWG------KQFLQRFPETLMEIEIPIVDHSTCQ 615

Query: 375 EV---MSNMVSENMLCAGILGDRQDACEGDSGGPMVA--SFHGTWFLVGLVSWGEGCGLL 429
           +    +   V+ +M+CAG     +DAC GDSGGPMV      G W+LVG VSWG+ CG  
Sbjct: 616 KAYAPLKKKVTRDMICAGEKEGGKDACAGDSGGPMVTLNRERGQWYLVGTVSWGDDCGKK 675

Query: 430 HNYGVYTKVSRYLDWI 445
             YGVY+ +    DWI
Sbjct: 676 DRYGVYSYIHHNKDWI 691



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 13/29 (44%), Positives = 14/29 (48%)

Query: 147 CTHYCLEEVGWRRCSCAPGYKLGDDLLQC 175
           C HYC   +G   CSC  GY L  D   C
Sbjct: 153 CDHYCHNYIGGYYCSCRFGYILHTDNRTC 181


>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
          Length = 275

 Score =  153 bits (386), Expect = 4e-37
 Identities = 91/254 (35%), Positives = 129/254 (50%), Gaps = 23/254 (9%)

Query: 212 LIDGKMTRRGDSPWQVVLLDSKKKLA--CGAVLIHPSWVLTAAHCMDESKKLLVRLGEYD 269
           ++ G+   R   PWQV L          CG  LIHP WVLTAAHC+    K L  L    
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAAL-RVQ 89

Query: 270 LRRWEKWELD--LDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
           LR    +  D  L +  + VHP +  +    DIALL L +P  +S  +  + LP +    
Sbjct: 90  LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPAS--- 146

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS--------- 378
            E    G    VTGWG     + + +    F L  +K+P++ ++ C              
Sbjct: 147 -ETFPPGMPCWVTGWG---DVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDV 202

Query: 379 NMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKV 438
            +V ++MLCAG    R+D+C+GDSGGP+V   +GTW   G+VSWGEGC   +  G+YT+V
Sbjct: 203 RIVRDDMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRV 260

Query: 439 SRYLDWIHGHIRDK 452
           + YLDWIH ++  K
Sbjct: 261 TYYLDWIHHYVPKK 274


>gi|91823048 kallikrein 14 preproprotein [Homo sapiens]
          Length = 267

 Score =  152 bits (383), Expect = 8e-37
 Identities = 95/258 (36%), Positives = 131/258 (50%), Gaps = 28/258 (10%)

Query: 201 TEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDS-KKKLACGAVLIHPSWVLTAAHCMDESK 259
           T+ QED+   ++I G    R   PWQ  LL   +++  CG  L+   WV+TAAHC     
Sbjct: 32  TQSQEDE--NKIIGGHTCTRSSQPWQAALLAGPRRRFLCGGALLSGQWVITAAHC--GRP 87

Query: 260 KLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPIC 319
            L V LG+++LRRWE  +  L +     HPNY+  T DND+ LL L QPA + + + PI 
Sbjct: 88  ILQVALGKHNLRRWEATQQVLRVVRQVTHPNYNSRTHDNDLMLLQLQQPARIGRAVRPI- 146

Query: 320 LPDSGLAERELNQA----GQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSE 375
                    E+ QA    G    V+GWG  SS       +    L  + I + P   C +
Sbjct: 147 ---------EVTQACASPGTSCRVSGWGTISSPIARYPAS----LQCVNINISPDEVCQK 193

Query: 376 VMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWG-EGCGLLHNYGV 434
                ++  M+CAG+    +D+C+GDSGGP+V        L GLVSWG E C L    GV
Sbjct: 194 AYPRTITPGMVCAGVPQGGKDSCQGDSGGPLVCRGQ----LQGLVSWGMERCALPGYPGV 249

Query: 435 YTKVSRYLDWIHGHIRDK 452
           YT + +Y  WI   +RDK
Sbjct: 250 YTNLCKYRSWIEETMRDK 267


>gi|4506143 neurotrypsin precursor [Homo sapiens]
          Length = 875

 Score =  152 bits (383), Expect = 8e-37
 Identities = 92/250 (36%), Positives = 133/250 (53%), Gaps = 25/250 (10%)

Query: 211 RLIDGKMTRRGDSPWQVVL-LDSKK---KLACGAVLIHPSWVLTAAHCM----DESKKLL 262
           R+I GK + RG  PWQV L L S     +L CGA L+   WVLTAAHC     + ++   
Sbjct: 630 RIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLTAAHCFKRYGNSTRSYA 689

Query: 263 VRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQP----ATLSQTIVPI 318
           VR+G+Y     E++E ++ ++++ +H  Y    +D DIAL+ L  P    A  S  ++P 
Sbjct: 690 VRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPA 749

Query: 319 CLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS 378
           CLP   L      +      +TGWG       +  R  +  L    IP++P   C E   
Sbjct: 750 CLP---LWRERPQKTASNCYITGWG-------DTGRAYSRTLQQAAIPLLPKRFCEERYK 799

Query: 379 NMVSENMLCAGILGD--RQDACEGDSGGPMVASFHG-TWFLVGLVSWGEGCGLLHNYGVY 435
              +  MLCAG L +  R D+C+GDSGGP++    G +W + G+ SWG GCG+  + GVY
Sbjct: 800 GRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSWGYGCGVKDSPGVY 859

Query: 436 TKVSRYLDWI 445
           TKVS ++ WI
Sbjct: 860 TKVSAFVPWI 869


>gi|4503137 chymotrypsin-like [Homo sapiens]
          Length = 264

 Score =  152 bits (383), Expect = 8e-37
 Identities = 86/236 (36%), Positives = 125/236 (52%), Gaps = 10/236 (4%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDL 270
           R+++G+    G  PWQV L DS     CG  LI  SWV+TAAHC     +  V LGEYD 
Sbjct: 33  RIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTAAHCNVSPGRHFVVLGEYDR 92

Query: 271 RRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAEREL 330
               +    L +     HP+++ +T +ND+ LL LA PA  +  I P+CL  S  A  E 
Sbjct: 93  SSNAEPLQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCLASSNEALTE- 151

Query: 331 NQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI 390
              G   + TGWG  S        +    L  + +P+V  N+C +   + ++++M+CAG 
Sbjct: 152 ---GLTCVTTGWGRLSGVGNVTPAH----LQQVALPLVTVNQCRQYWGSSITDSMICAG- 203

Query: 391 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH 446
            G    +C+GDSGGP+V     TW L+G+VSWG     +    VYT+VS++  WI+
Sbjct: 204 -GAGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTWIN 258


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  151 bits (382), Expect = 1e-36
 Identities = 83/245 (33%), Positives = 132/245 (53%), Gaps = 15/245 (6%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYD- 269
           R++ G+    G  PWQV L   +    CG  +I P W++TAAHC+++          +  
Sbjct: 292 RIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 350

Query: 270 -LRR-WEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
            LR+ +  +     +++V  HPNY   T +NDIAL+ L +P T +  + P+CLP+ G+  
Sbjct: 351 ILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGM-- 408

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSE--VMSNMVSENM 385
             + Q  Q   ++GWG    + K ++     VLN  K+ ++    C+   V  N+++  M
Sbjct: 409 --MLQPEQLCWISGWGATEEKGKTSE-----VLNAAKVLLIETQRCNSRYVYDNLITPAM 461

Query: 386 LCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           +CAG L    D+C+GDSGGP+V S +  W+L+G  SWG GC   +  GVY  V  + DWI
Sbjct: 462 ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521

Query: 446 HGHIR 450
           +  +R
Sbjct: 522 YRQMR 526


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  151 bits (382), Expect = 1e-36
 Identities = 83/245 (33%), Positives = 132/245 (53%), Gaps = 15/245 (6%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYD- 269
           R++ G+    G  PWQV L   +    CG  +I P W++TAAHC+++          +  
Sbjct: 255 RIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313

Query: 270 -LRR-WEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
            LR+ +  +     +++V  HPNY   T +NDIAL+ L +P T +  + P+CLP+ G+  
Sbjct: 314 ILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGM-- 371

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSE--VMSNMVSENM 385
             + Q  Q   ++GWG    + K ++     VLN  K+ ++    C+   V  N+++  M
Sbjct: 372 --MLQPEQLCWISGWGATEEKGKTSE-----VLNAAKVLLIETQRCNSRYVYDNLITPAM 424

Query: 386 LCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           +CAG L    D+C+GDSGGP+V S +  W+L+G  SWG GC   +  GVY  V  + DWI
Sbjct: 425 ICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484

Query: 446 HGHIR 450
           +  +R
Sbjct: 485 YRQMR 489


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  147 bits (371), Expect = 2e-35
 Identities = 92/248 (37%), Positives = 128/248 (51%), Gaps = 22/248 (8%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHC-----MDESKKLLVRL 265
           R+I G  T  G  PWQV L        CGA +I   W+L+AAHC     + +       L
Sbjct: 479 RIIGGTDTLEGGWPWQVSL-HFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHL 537

Query: 266 GEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHL--AQPATLSQTIVPICLPDS 323
           G Y     +       ++ + VH  Y+  T D DIALL L  A P TL Q I PIC+P +
Sbjct: 538 GMYVQGNAK---FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPT 594

Query: 324 GLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSE 383
           G   R    +G++  VTGWG    R  EA    + VL   ++ ++    C      +++ 
Sbjct: 595 GQRVR----SGEKCWVTGWG----RRHEADNKGSLVLQQAEVELIDQTLCVSTYG-IITS 645

Query: 384 NMLCAGILGDRQDACEGDSGGPMVA--SFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRY 441
            MLCAGI+  ++DAC+GDSGGP+       G W L G+VSWG G G  +  GVYT+VS +
Sbjct: 646 RMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNF 705

Query: 442 LDWIHGHI 449
           + WIH ++
Sbjct: 706 VPWIHKYV 713


>gi|61744424 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  147 bits (371), Expect = 2e-35
 Identities = 93/243 (38%), Positives = 126/243 (51%), Gaps = 20/243 (8%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDL 270
           +L+ G    +   P+Q  L  S   L CG VLIHP WVLTAAHC  +   L V LG+++L
Sbjct: 21  KLVHGGPCDKTSHPYQAALYTSGH-LLCGGVLIHPLWVLTAAHC--KKPNLQVFLGKHNL 77

Query: 271 RRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAEREL 330
           R+ E  +    +    +HP+Y  ++ D DI LL LA+PA LS+ I P+ L      ER+ 
Sbjct: 78  RQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPL------ERDC 131

Query: 331 NQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI 390
           +       + GWG      K A  +    +    I +V   EC       +++NMLCAG 
Sbjct: 132 SANTTSCHILGWG------KTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGD 185

Query: 391 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGE-GCGLLHNYGVYTKVSRYLDWIHGHI 449
               +D+C+GDSGGP+V   H    L GLVSWG   CG     GVYT V RY +WI   I
Sbjct: 186 EKYGKDSCQGDSGGPLVCGDH----LRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTI 241

Query: 450 RDK 452
           + K
Sbjct: 242 QAK 244


>gi|4506155 kallikrein-related peptidase 6 isoform A preproprotein
           [Homo sapiens]
          Length = 244

 Score =  147 bits (371), Expect = 2e-35
 Identities = 93/243 (38%), Positives = 126/243 (51%), Gaps = 20/243 (8%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDL 270
           +L+ G    +   P+Q  L  S   L CG VLIHP WVLTAAHC  +   L V LG+++L
Sbjct: 21  KLVHGGPCDKTSHPYQAALYTSGH-LLCGGVLIHPLWVLTAAHC--KKPNLQVFLGKHNL 77

Query: 271 RRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAEREL 330
           R+ E  +    +    +HP+Y  ++ D DI LL LA+PA LS+ I P+ L      ER+ 
Sbjct: 78  RQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPL------ERDC 131

Query: 331 NQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGI 390
           +       + GWG      K A  +    +    I +V   EC       +++NMLCAG 
Sbjct: 132 SANTTSCHILGWG------KTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGD 185

Query: 391 LGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGE-GCGLLHNYGVYTKVSRYLDWIHGHI 449
               +D+C+GDSGGP+V   H    L GLVSWG   CG     GVYT V RY +WI   I
Sbjct: 186 EKYGKDSCQGDSGGPLVCGDH----LRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTI 241

Query: 450 RDK 452
           + K
Sbjct: 242 QAK 244


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  147 bits (370), Expect = 3e-35
 Identities = 95/241 (39%), Positives = 125/241 (51%), Gaps = 21/241 (8%)

Query: 224 PWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIK 283
           PWQ  LL  + +L CG VL+HP WVLTAAHC+ E  K  V LG++ L R E  E   ++ 
Sbjct: 48  PWQAALL-VQGRLLCGGVLVHPKWVLTAAHCLKEGLK--VYLGKHALGRVEAGEQVREVV 104

Query: 284 EVFVHPNYSKSTT----DNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLV 339
               HP Y +S T    D+DI LL L  P  L+  I  +      L+       G    V
Sbjct: 105 HSIPHPEYRRSPTHLNHDHDIMLLELQSPVQLTGYIQTL-----PLSHNNRLTPGTTCRV 159

Query: 340 TGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACE 399
           +GWG  +S +     N    L    I +    EC +V    +++NMLCAG     +D+CE
Sbjct: 160 SGWGTTTSPQV----NYPKTLQCANIQLRSDEECRQVYPGKITDNMLCAGTKEGGKDSCE 215

Query: 400 GDSGGPMVASFHGTWFLVGLVSWGE-GCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKS 458
           GDSGGP+V +      L G+VSWG+  CG     GVYT+VSRY+ WI   IR  E  Q+ 
Sbjct: 216 GDSGGPLVCN----RTLYGIVSWGDFPCGQPDRPGVYTRVSRYVLWIRETIRKYETQQQK 271

Query: 459 W 459
           W
Sbjct: 272 W 272


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  146 bits (368), Expect = 4e-35
 Identities = 87/257 (33%), Positives = 123/257 (47%), Gaps = 20/257 (7%)

Query: 205 EDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESK---KL 261
           + ++  R++ G+  R G+ PWQ  +   +    CG  LI P WVLTAAHC        + 
Sbjct: 30  QPRMSSRIVGGRDGRDGEWPWQASI-QHRGAHVCGGSLIAPQWVLTAAHCFPRRALPAEY 88

Query: 262 LVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLP 321
            VRLG   L       L + ++ V + P+YS+     D+ALL L +P  LS  + P+CLP
Sbjct: 89  RVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLP 148

Query: 322 DSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVM---- 377
             G         G    VTGWG   S            L  +++P++    C  +     
Sbjct: 149 VPGARP----PPGTPCRVTGWG---SLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGA 201

Query: 378 -----SNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNY 432
                  +V    LCAG     +DAC+GDSGGP+     G+W LVG+VSWG+GC L +  
Sbjct: 202 DVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRP 261

Query: 433 GVYTKVSRYLDWIHGHI 449
           GVYT V+ Y  WI   +
Sbjct: 262 GVYTSVATYSPWIQARV 278


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  145 bits (366), Expect = 8e-35
 Identities = 102/316 (32%), Positives = 149/316 (47%), Gaps = 48/316 (15%)

Query: 149 HYCLE---EVGWRRCSCAPGYKLGD--DLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTED 203
           +YC     +VG   C      KL D  D+ QC  A  F CG+P  ++E K+         
Sbjct: 529 NYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQC-AAPSFDCGKP--QVEPKKC-------- 577

Query: 204 QEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK--- 260
                  R++ G +      PWQV L        CG  LI P WVLTAAHC+++S +   
Sbjct: 578 -----PGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSS 632

Query: 261 LLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICL 320
             V LG +     E    ++++  +F+ P      T  DIALL L+ PA ++  ++P CL
Sbjct: 633 YKVILGAHQEVNLEPHVQEIEVSRLFLEP------TRKDIALLKLSSPAVITDKVIPACL 686

Query: 321 PDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIK---IPVVPHNECS--E 375
           P       +      E  +TGWG         +   TF    +K   +PV+ +  C+  E
Sbjct: 687 PSPNYVVADRT----ECFITGWG---------ETQGTFGAGLLKEAQLPVIENKVCNRYE 733

Query: 376 VMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVY 435
            ++  V    LCAG L    D+C+GDSGGP+V      + L G+ SWG GC   +  GVY
Sbjct: 734 FLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVY 793

Query: 436 TKVSRYLDWIHGHIRD 451
            +VSR++ WI G +R+
Sbjct: 794 VRVSRFVTWIEGVMRN 809


>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  144 bits (364), Expect = 1e-34
 Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 22/242 (9%)

Query: 209 DPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEY 268
           + R+I G   +    PWQ  L + K +L CGA LI P W+LTAAHC+    + +V LG++
Sbjct: 19  ETRIIKGFECKPHSQPWQAALFE-KTRLLCGATLIAPRWLLTAAHCL--KPRYIVHLGQH 75

Query: 269 DLRRWEKWELDLDIKEVFVHPNYSKSTTD----NDIALLHLAQPATLSQTIVPICLPDSG 324
           +L++ E  E      E F HP ++ S  +    NDI L+ +A P +++  + P+ L    
Sbjct: 76  NLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC 135

Query: 325 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN 384
           +       AG   L++GWG  SS +          L    I ++ H +C       +++ 
Sbjct: 136 VT------AGTSCLISGWGSTSSPQLRLPHT----LRCANITIIEHQKCENAYPGNITDT 185

Query: 385 MLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEG-CGLLHNYGVYTKVSRYLD 443
           M+CA +    +D+C+GDSGGP+V +      L G++SWG+  C +    GVYTKV +Y+D
Sbjct: 186 MVCASVQEGGKDSCQGDSGGPLVCN----QSLQGIISWGQDPCAITRKPGVYTKVCKYVD 241

Query: 444 WI 445
           WI
Sbjct: 242 WI 243


>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
          Length = 282

 Score =  144 bits (364), Expect = 1e-34
 Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 22/242 (9%)

Query: 209 DPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEY 268
           + R+I G   +    PWQ  L + K +L CGA LI P W+LTAAHC+    + +V LG++
Sbjct: 51  ETRIIKGFECKPHSQPWQAALFE-KTRLLCGATLIAPRWLLTAAHCL--KPRYIVHLGQH 107

Query: 269 DLRRWEKWELDLDIKEVFVHPNYSKSTTD----NDIALLHLAQPATLSQTIVPICLPDSG 324
           +L++ E  E      E F HP ++ S  +    NDI L+ +A P +++  + P+ L    
Sbjct: 108 NLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC 167

Query: 325 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN 384
           +       AG   L++GWG  SS +          L    I ++ H +C       +++ 
Sbjct: 168 VT------AGTSCLISGWGSTSSPQLRLPHT----LRCANITIIEHQKCENAYPGNITDT 217

Query: 385 MLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEG-CGLLHNYGVYTKVSRYLD 443
           M+CA +    +D+C+GDSGGP+V +      L G++SWG+  C +    GVYTKV +Y+D
Sbjct: 218 MVCASVQEGGKDSCQGDSGGPLVCN----QSLQGIISWGQDPCAITRKPGVYTKVCKYVD 273

Query: 444 WI 445
           WI
Sbjct: 274 WI 275


>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  144 bits (364), Expect = 1e-34
 Identities = 81/242 (33%), Positives = 128/242 (52%), Gaps = 22/242 (9%)

Query: 209 DPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEY 268
           + R+I G   +    PWQ  L + K +L CGA LI P W+LTAAHC+    + +V LG++
Sbjct: 19  ETRIIKGFECKPHSQPWQAALFE-KTRLLCGATLIAPRWLLTAAHCL--KPRYIVHLGQH 75

Query: 269 DLRRWEKWELDLDIKEVFVHPNYSKSTTD----NDIALLHLAQPATLSQTIVPICLPDSG 324
           +L++ E  E      E F HP ++ S  +    NDI L+ +A P +++  + P+ L    
Sbjct: 76  NLQKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRC 135

Query: 325 LAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSEN 384
           +       AG   L++GWG  SS +          L    I ++ H +C       +++ 
Sbjct: 136 VT------AGTSCLISGWGSTSSPQLRLPHT----LRCANITIIEHQKCENAYPGNITDT 185

Query: 385 MLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEG-CGLLHNYGVYTKVSRYLD 443
           M+CA +    +D+C+GDSGGP+V +      L G++SWG+  C +    GVYTKV +Y+D
Sbjct: 186 MVCASVQEGGKDSCQGDSGGPLVCN----QSLQGIISWGQDPCAITRKPGVYTKVCKYVD 241

Query: 444 WI 445
           WI
Sbjct: 242 WI 243


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  144 bits (364), Expect = 1e-34
 Identities = 82/252 (32%), Positives = 126/252 (50%), Gaps = 19/252 (7%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDES---KKLLVRLGE 267
           R+  G     G  PWQV +      + CG  L+   WVL+AAHC       +   V+LG 
Sbjct: 44  RITGGSSAVAGQWPWQVSITYEGVHV-CGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA 102

Query: 268 YDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
           + L  + +      +K++  HP+Y +  +  DIALL L++P T S+ I PICLP +  + 
Sbjct: 103 HQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASF 162

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMS--------N 379
                 G    VTGWG+ +             L  +++P++    C+ + +        +
Sbjct: 163 PN----GLHCTVTGWGHVAPSVSLLTPKP---LQQLEVPLISRETCNCLYNIDAKPEEPH 215

Query: 380 MVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVS 439
            V E+M+CAG +   +DAC+GDSGGP+     G W+L G+VSWG+ CG  +  GVYT  S
Sbjct: 216 FVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLAS 275

Query: 440 RYLDWIHGHIRD 451
            Y  WI   + +
Sbjct: 276 SYASWIQSKVTE 287


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  144 bits (363), Expect = 2e-34
 Identities = 80/239 (33%), Positives = 128/239 (53%), Gaps = 13/239 (5%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESK---KLLVRLGE 267
           R++ G     G+ PWQ  L ++K+   CGA +I+  W+++AAHC +E +   K +  +G 
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHF-CGAAIINARWLVSAAHCFNEFQDPTKWVAYVGA 260

Query: 268 YDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
             L   E   +   + ++  HP Y+  T D D+A+L L  P    + I P+CLP    A 
Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLP----AA 316

Query: 328 RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLC 387
             +    ++ L++GWGY     KE    +  VL    + ++    C+ +  + +++ M+C
Sbjct: 317 THIFPPSKKCLISGWGYL----KEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVC 372

Query: 388 AGILGDRQDACEGDSGGPMVASF-HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           AG L  + D+C+GDSGGP+V     G +FL G+VSWG GC      GVY +V+R  DWI
Sbjct: 373 AGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWI 431



 Score =  143 bits (361), Expect = 3e-34
 Identities = 78/238 (32%), Positives = 130/238 (54%), Gaps = 12/238 (5%)

Query: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVR--LGEY 268
           R++ G     G+ PWQV L +  +   CGA ++   W+L+AAHC + +K   VR  LG  
Sbjct: 503 RVVGGFGAASGEVPWQVSLKEGSRHF-CGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTA 561

Query: 269 DLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAER 328
            L       + + ++ V +HP Y+    D D+A+L LA P   ++ I P+CLP   LA +
Sbjct: 562 SLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVCLP---LAIQ 618

Query: 329 ELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCA 388
           +    G++ +++GWG      +E    +  +L    + ++    CS + +  +++ M+CA
Sbjct: 619 KF-PVGRKCMISGWG----NTQEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICA 673

Query: 389 GILGDRQDACEGDSGGPMVA-SFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWI 445
           G L  + D+C+GDSGGP+      G ++L G+VSWG GC  +   GVYT+++R   WI
Sbjct: 674 GFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWI 731



 Score =  142 bits (359), Expect = 5e-34
 Identities = 88/245 (35%), Positives = 126/245 (51%), Gaps = 15/245 (6%)

Query: 211  RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMD---ESKKLLVRLGE 267
            R++ G    RG+ PWQV L   +++  CGAVL+   W+L+AAHC D   + K+    LG 
Sbjct: 826  RIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGT 885

Query: 268  YDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAE 327
              L   E  +L+  +  ++ HP Y+  T D D+ALL LA P   S+ + PICLP+     
Sbjct: 886  PFLSGAE-GQLE-RVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRP 943

Query: 328  RELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLC 387
             +    G   ++TGWG  S RE  +   +   L    + ++    C       +S  MLC
Sbjct: 944  PD----GTRCVITGWG--SVREGGSMARQ---LQKAAVRLLSEQTCRRFYPVQISSRMLC 994

Query: 388  AGILGDRQDACEGDSGGPMVA-SFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIH 446
            AG      D+C GD+GGP+      G W L G+ SWG GCG  H  GVYT+V+    WI 
Sbjct: 995  AGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIG 1054

Query: 447  GHIRD 451
             HI++
Sbjct: 1055 QHIQE 1059


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.454 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,768,356
Number of Sequences: 37866
Number of extensions: 946794
Number of successful extensions: 4803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 296
Number of HSP's successfully gapped in prelim test: 107
Number of HSP's that attempted gapping in prelim test: 2420
Number of HSP's gapped (non-prelim): 1484
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.