Search of human proteins with 4505983

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo
sapiens]
         (1202 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sap...  2349   0.0  
gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo sa...  2313   0.0  
gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]         1561   0.0  
gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]         1378   0.0  
gi|55769554 protein tyrosine phosphatase, receptor type, f polyp...   793   0.0  
gi|157837985 kazrin isoform E [Homo sapiens]                          202   2e-51
gi|170784854 PTPRF interacting protein, binding protein 2 (lipri...   170   9e-42
gi|29294627 PTPRF interacting protein binding protein 1 isoform ...   159   2e-38
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   108   3e-23
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   108   3e-23
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   108   3e-23
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   108   3e-23
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   105   2e-22
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        99   2e-20
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        99   2e-20
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         99   2e-20
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         99   2e-20
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         99   2e-20
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         99   2e-20
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         99   2e-20
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         99   2e-20
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]    98   4e-20
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     98   5e-20
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    97   7e-20
gi|42794779 myosin 18A isoform b [Homo sapiens]                        97   9e-20
gi|28416946 myosin 18A isoform a [Homo sapiens]                        97   9e-20
gi|55770834 centromere protein F [Homo sapiens]                        97   9e-20
gi|31982906 cingulin-like 1 [Homo sapiens]                             96   3e-19
gi|16262452 cingulin [Homo sapiens]                                    95   3e-19
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             94   8e-19

>gi|4505983 PTPRF interacting protein alpha 1 isoform b [Homo sapiens]
          Length = 1202

 Score = 2349 bits (6087), Expect = 0.0
 Identities = 1202/1202 (100%), Positives = 1202/1202 (100%)

Query: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
            MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET
Sbjct: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60

Query: 61   LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120
            LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN
Sbjct: 61   LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120

Query: 121  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
            TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE
Sbjct: 121  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180

Query: 181  RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD
Sbjct: 181  RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240

Query: 241  GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
            GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM
Sbjct: 241  GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300

Query: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
            NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT
Sbjct: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360

Query: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420
            EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME
Sbjct: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420

Query: 421  AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480
            AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL
Sbjct: 421  AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480

Query: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD 540
            REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD
Sbjct: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD 540

Query: 541  GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV 600
            GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV
Sbjct: 541  GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV 600

Query: 601  SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI
Sbjct: 601  SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660

Query: 661  ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT 720
            ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT
Sbjct: 661  ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT 720

Query: 721  LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP 780
            LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP
Sbjct: 721  LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP 780

Query: 781  VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ 840
            VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ
Sbjct: 781  VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ 840

Query: 841  DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA 900
            DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA
Sbjct: 841  DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA 900

Query: 901  CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG 960
            CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG
Sbjct: 901  CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG 960

Query: 961  DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG 1020
            DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG
Sbjct: 961  DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG 1020

Query: 1021 IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA 1080
            IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA
Sbjct: 1021 IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA 1080

Query: 1081 LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW 1140
            LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW
Sbjct: 1081 LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW 1140

Query: 1141 RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTY 1200
            RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTY
Sbjct: 1141 RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTY 1200

Query: 1201 SC 1202
            SC
Sbjct: 1201 SC 1202


>gi|29171753 PTPRF interacting protein alpha 1 isoform a [Homo
            sapiens]
          Length = 1185

 Score = 2313 bits (5995), Expect = 0.0
 Identities = 1184/1184 (100%), Positives = 1184/1184 (100%)

Query: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
            MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET
Sbjct: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60

Query: 61   LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120
            LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN
Sbjct: 61   LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120

Query: 121  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
            TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE
Sbjct: 121  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180

Query: 181  RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD
Sbjct: 181  RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240

Query: 241  GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
            GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM
Sbjct: 241  GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300

Query: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
            NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT
Sbjct: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360

Query: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420
            EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME
Sbjct: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420

Query: 421  AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480
            AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL
Sbjct: 421  AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480

Query: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD 540
            REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD
Sbjct: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD 540

Query: 541  GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV 600
            GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV
Sbjct: 541  GHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADV 600

Query: 601  SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI
Sbjct: 601  SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660

Query: 661  ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT 720
            ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT
Sbjct: 661  ESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMT 720

Query: 721  LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP 780
            LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP
Sbjct: 721  LLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGP 780

Query: 781  VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ 840
            VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ
Sbjct: 781  VSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQ 840

Query: 841  DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA 900
            DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA
Sbjct: 841  DALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAA 900

Query: 901  CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG 960
            CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG
Sbjct: 901  CRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYG 960

Query: 961  DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG 1020
            DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG
Sbjct: 961  DMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCG 1020

Query: 1021 IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA 1080
            IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA
Sbjct: 1021 IMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGA 1080

Query: 1081 LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW 1140
            LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW
Sbjct: 1081 LLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSW 1140

Query: 1141 RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDG 1184
            RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDG
Sbjct: 1141 RKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDG 1184


>gi|29171755 PTPRF interacting protein alpha 2 [Homo sapiens]
          Length = 1257

 Score = 1561 bits (4041), Expect = 0.0
 Identities = 851/1285 (66%), Positives = 1003/1285 (78%), Gaps = 111/1285 (8%)

Query: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
            MMCEVMPTI+E + P    G   SGS    D+DSHFEQLMV+ML+ERDRLLDTLRETQE+
Sbjct: 1    MMCEVMPTINE-DTPMSQRGSQSSGS----DSDSHFEQLMVNMLDERDRLLDTLRETQES 55

Query: 61   LALTQGKLHEVGHERDSLQRQLNTALPQ------------------EFAALTKELNVCRE 102
            L+L Q +L +V ++RDSLQRQLN+ALPQ                  EFAALTKELN CRE
Sbjct: 56   LSLAQQRLQDVIYDRDSLQRQLNSALPQDIESLTGGLAGSKGADPPEFAALTKELNACRE 115

Query: 103  QLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLK 162
            QLLE+EEEI+ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSP+GVSSEVEVLK
Sbjct: 116  QLLEKEEEISELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPSGVSSEVEVLK 175

Query: 163  ALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQN---NQKKTLTDG 219
            ALKSLFEHHKALDEKVRERLRV+LER S LEEEL A ++E++ L+EQN    +K   ++G
Sbjct: 176  ALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEIVALREQNVHIQRKMASSEG 235

Query: 220  VLDINHEQENTPSTS--GKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLS 277
              +  H +   P      KR S+GS+   ++ ++++ELQE++ KQ+ E +QMKERLA+LS
Sbjct: 236  STESEHLEGMEPGQKVHEKRLSNGSIDSTDETSQIVELQELLEKQNYEMAQMKERLAALS 295

Query: 278  SHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT 337
            S V E+E++ +TARKDLIK+EEMNTK QRD+REAMAQKEDMEERITTLEKRYL+AQRE+T
Sbjct: 296  SRVGEVEQEAETARKDLIKTEEMNTKYQRDIREAMAQKEDMEERITTLEKRYLSAQREST 355

Query: 338  SVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQ 397
            S+HD+NDKLENE+ANK+++ RQ E+KNRQLQERLELAEQKLQQT+RKAETLPEVEAELAQ
Sbjct: 356  SIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQTMRKAETLPEVEAELAQ 415

Query: 398  RVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE 457
            R+AAL+KAEERHGNIEER+R +E QLEEKNQELQRARQREKMNEEHNKRLSDTVD+LL+E
Sbjct: 416  RIAALTKAEERHGNIEERMRHLEGQLEEKNQELQRARQREKMNEEHNKRLSDTVDRLLTE 475

Query: 458  SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLR 517
            SNERLQLHLKERMAALE+KN L++E E+ +K LEE+ HDK++L   IE LR+ELD +++R
Sbjct: 476  SNERLQLHLKERMAALEEKNVLIQESETFRKNLEESLHDKERLAEEIEKLRSELDQLKMR 535

Query: 518  GASLHH---GRPHLGSVPDFRF---PMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQ 571
              SL      R HL +  + R+    + D  +D Y T+ V+RRP++GR+   RDEP KV+
Sbjct: 536  TGSLIEPTIPRTHLDTSAELRYSVGSLVDSQSD-YRTTKVIRRPRRGRMGVRRDEP-KVK 593

Query: 572  TLNEQDWERAQQASVLANVAQAFESDADVSD-GEDDRDTLLSSVDLLSPSGQADAHTLAM 630
            +L + +W R QQ  VL+  +  FESD ++SD  +DDR+T+ SS+DLLSPSG +DA TLAM
Sbjct: 594  SLGDHEWNRTQQIGVLS--SHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAM 651

Query: 631  MLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLD--NLGRFRSMSSI-PPYPAS 687
            MLQEQLDAINKEIRLIQEEKE+TE RAEEIE+RV S SL+  NL R    +SI     AS
Sbjct: 652  MLQEQLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVHPGTSITASVTAS 711

Query: 688  SLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSR----------EEVRDDKTTIK 737
            SLASSSPP SG STP+  P SPARE+DR+GVMTL    R          E+ R+DK TIK
Sbjct: 712  SLASSSPP-SGHSTPKLTPRSPAREMDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIK 770

Query: 738  CETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVS-NPSSSNSSQDSLHK 796
            CETSPP +PRALR+        HT+      D R+S      P S    S+NSSQDSLHK
Sbjct: 771  CETSPPPTPRALRM-------THTLPSSYHNDARSSLSVSLEPESLGLGSANSSQDSLHK 823

Query: 797  APKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNR 856
            APKKKGIKSSIGRLFGKKEK R GQ         G  ET+ ++Q++LGL KLG QAEK+R
Sbjct: 824  APKKKGIKSSIGRLFGKKEKARLGQL-------RGFMETEAAAQESLGLGKLGTQAEKDR 876

Query: 857  KLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSD 916
            +L+KKHELLEEARR+GLPFAQWDGPTVV WLELW+GMPAWYVAACRANVKSGAIMSALSD
Sbjct: 877  RLKKKHELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSD 936

Query: 917  TEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRT--------------------- 955
            TEIQREIGISNPLHRLKLRLAIQE++SLTSPSAPPTSRT                     
Sbjct: 937  TEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLAAPAKT 996

Query: 956  ----------------TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 999
                            TLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK
Sbjct: 997  KESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTK 1056

Query: 1000 KDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRW 1059
            KDLR  LKMVDSFHR S Q GIMCL+RLNYDRKELER+RE SQ EIKDVLVWSNDRVIRW
Sbjct: 1057 KDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRW 1116

Query: 1060 ILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLV 1119
            I +IGL+EYANN++ESGVHG+L+ALDE FD+S+LALLLQIPTQNTQAR +LERE+NNLL 
Sbjct: 1117 IQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREYNNLLA 1176

Query: 1120 MGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLA--AGSAETLPANFRVTSSMSSPSMQP 1177
            +GT+RR DE DDK+FRR  +WR++F P+++ G++   GS+ETLPA FR+T++    S Q 
Sbjct: 1177 LGTERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLTTT----SGQS 1232

Query: 1178 KKMQMDGNVSGTQRLDSATVRTYSC 1202
            +KM  D   S  QRLD++TVRTYSC
Sbjct: 1233 RKMTTDVASSRLQRLDNSTVRTYSC 1257


>gi|32189362 PTPRF interacting protein alpha 3 [Homo sapiens]
          Length = 1194

 Score = 1378 bits (3566), Expect = 0.0
 Identities = 757/1244 (60%), Positives = 920/1244 (73%), Gaps = 92/1244 (7%)

Query: 1    MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQET 60
            MMCEVMPTISE         G    +    +A    E+LMV+ML ER+RLL+TLRE Q+ 
Sbjct: 1    MMCEVMPTISE--------DGRRGSALGPDEAGGELERLMVTMLTERERLLETLREAQDG 52

Query: 61   LALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNN 120
            LA  Q +L E+GHE+DSLQRQL+ ALPQEFAALTKELN+CREQLLEREEEIAELKAERNN
Sbjct: 53   LATAQLRLRELGHEKDSLQRQLSIALPQEFAALTKELNLCREQLLEREEEIAELKAERNN 112

Query: 121  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
            TRLLLEHLECLVSRHERSLRMTVVKRQAQSP GVSSEVEVLKALKSLFEHHKALDEKVRE
Sbjct: 113  TRLLLEHLECLVSRHERSLRMTVVKRQAQSPGGVSSEVEVLKALKSLFEHHKALDEKVRE 172

Query: 181  RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            RLR+ALER ++LEEEL  +++E + L+EQ +++++   G+      +E      G+  ++
Sbjct: 173  RLRMALERVAVLEEELELSNQETLNLREQLSRRRS---GL------EEPGKDGDGQTLAN 223

Query: 241  GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
            G     +   +  EL+E + +Q  E  Q++ERLA L   +++LEE+L TA ++L K+EE 
Sbjct: 224  GLGPGGDSNRRTAELEEALERQRAEVCQLRERLAVLCRQMSQLEEELGTAHRELGKAEEA 283

Query: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
            N+KLQRD++EA+AQ+EDMEERITTLEKRYL+AQREATS+HD NDKLENE+A+K+S++RQ+
Sbjct: 284  NSKLQRDLKEALAQREDMEERITTLEKRYLSAQREATSLHDANDKLENELASKESLYRQS 343

Query: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQME 420
            E+K+RQL E L+ A+QKLQQTL+KAETLPE+EA+LAQRVAAL+KAEERHGN EERLRQ+E
Sbjct: 344  EEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVAALNKAEERHGNFEERLRQLE 403

Query: 421  AQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLL 480
            AQLEEKNQELQRARQREKMN++HNKRLS+TVDKLLSESNERLQLHLKERM ALE+KNSL 
Sbjct: 404  AQLEEKNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQLHLKERMGALEEKNSLS 463

Query: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA- 539
             E+ + KK  +E   +K+QL+  +E ++ E+D +R R  S  + R   GS  + R+  A 
Sbjct: 464  EEIANMKKLQDELLLNKEQLLAEMERMQMEIDQLRGRPPS-SYSRSLPGSALELRYSQAP 522

Query: 540  ----DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFE 595
                  H D Y   +  R  ++GR + +++EPSK       DWER+  A    ++   F 
Sbjct: 523  TLPSGAHLDPYVAGSG-RAGKRGRWSGVKEEPSK-------DWERSAPA---GSIPPPFP 571

Query: 596  SDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQ 655
             + D SD E+     +   +LLSPSGQAD  TLA+MLQEQL+AINKEI+LIQEEKE TEQ
Sbjct: 572  GELDGSDEEEAEG--MFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKLIQEEKETTEQ 629

Query: 656  RAEEIESRVGSGSLDNLGRFRSMSSIPP-YPASSLASSSPPGSGRSTPRRIPHSPAREVD 714
            RAEE+ESRV S  LD+LGR+RS  S+PP    S+LAS SPP SG STPR  P SPARE  
Sbjct: 630  RAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSPARE-- 687

Query: 715  RLGVMTLLPPSREEV---RDDKTTIKCETSPPSSPRALRLDRLHKG-ALHTVSHEDIRDI 770
              G        +EE    R +   I  +T PP +PR+ RL+R+ +  AL   S ED    
Sbjct: 688  --GTDKANHVPKEEAGAPRGEGPAIPGDT-PPPTPRSARLERMTQALALQAGSLED---- 740

Query: 771  RNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQA 830
                    GP   P  S  + DSLHKAPKKK IKSSIGRLFGKKEKGR G  G+++   A
Sbjct: 741  -------GGP---PRGSEGTPDSLHKAPKKKSIKSSIGRLFGKKEKGRMGPPGRDSSSLA 790

Query: 831  GVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELW 890
            G    +  + D LGL+KL G  +K+R+ ++KHELLEEA RQGLPFA WDGPTVV WLELW
Sbjct: 791  GTPSDETLATDPLGLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELW 850

Query: 891  VGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAP 950
            VGMPAWYVAACRANVKSGAIM+ LSDTEIQREIGISNPLHRLKLRLAIQE++SLTSPSAP
Sbjct: 851  VGMPAWYVAACRANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAP 910

Query: 951  PTSRTT------------------------------LAYGDMNHEWIGNEWLPSLGLPQY 980
             +SRT+                              LAYGDMNHEW+GN+WLPSLGLPQY
Sbjct: 911  ASSRTSTGNVWMTHEEMESLTATTKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQY 970

Query: 981  RSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREE 1040
            RSYFME LVDARMLDHL KK+LRGQLKMVDSFHR S   GIMCL+RLNYDRK+LER+REE
Sbjct: 971  RSYFMESLVDARMLDHLNKKELRGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREE 1030

Query: 1041 SQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIP 1100
            SQ++I+DV+VWSN+RV+ W+  +GLKE+A NL ESGVHGALLALDETFD+S LALLLQIP
Sbjct: 1031 SQTQIRDVMVWSNERVMGWVSGLGLKEFATNLTESGVHGALLALDETFDYSDLALLLQIP 1090

Query: 1101 TQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETL 1160
            TQN QAR +LE+EF+NL+ +GTDRR DED  KSF R+PSWRK FR KD+RG+   SAE L
Sbjct: 1091 TQNAQARQLLEKEFSNLISLGTDRRLDEDSAKSFSRSPSWRKMFREKDLRGVTPDSAEML 1150

Query: 1161 PANFR--VTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTYSC 1202
            P NFR     ++ SP +  +K+Q +G  SG+ R D  +VRTYSC
Sbjct: 1151 PPNFRSAAAGALGSPGLPLRKLQPEGQTSGSSRADGVSVRTYSC 1194


>gi|55769554 protein tyrosine phosphatase, receptor type, f
            polypeptide (PTPRF), interacting protein (liprin), alpha
            4 [Homo sapiens]
          Length = 701

 Score =  793 bits (2049), Expect = 0.0
 Identities = 440/711 (61%), Positives = 523/711 (73%), Gaps = 77/711 (10%)

Query: 528  LGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVL 587
            +GS  D RF +    T +++   V RR      +ALR+E +K       DWE +    +L
Sbjct: 1    MGSAADVRFSLG---TTTHAPPGVHRR-----YSALREESAK-------DWETSPLPGML 45

Query: 588  ANVA-QAFESDADVSD-GEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRL 645
            A  A  AF+SD ++SD  ED+   L+ S D++SPSG +DA TLAMMLQEQLDAIN+EIR+
Sbjct: 46   APAAGPAFDSDPEISDVDEDEPGGLVGSADVVSPSGHSDAQTLAMMLQEQLDAINEEIRM 105

Query: 646  IQEEKENTEQRAEEIESRVGSGSLD--NLGRFRSMSSIPP-YPASSLASSSPPGSGRSTP 702
            IQEEKE+TE RAEEIE+RV SGS++  NL + R   SIP    A SLAS+SPP SGRSTP
Sbjct: 106  IQEEKESTELRAEEIETRVTSGSMEALNLKQLRKRGSIPTSLTALSLASASPPLSGRSTP 165

Query: 703  RRIPHSPAREVDRLGVMTL------------LPPSREEVRDDKTTIKCETSPPSSPRALR 750
            +    S A+++DR+GVMTL             P SREE R+DK TIKCETSPPSSPR LR
Sbjct: 166  KLTSRSAAQDLDRMGVMTLPSDLRKHRRKLLSPVSREENREDKATIKCETSPPSSPRTLR 225

Query: 751  LDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRL 810
            L++L   AL   S E+ +      GS      NPSSSNSSQDSLHK  K+KGIKSSIGRL
Sbjct: 226  LEKLGHPAL---SQEEGKSALEDQGS------NPSSSNSSQDSLHKGAKRKGIKSSIGRL 276

Query: 811  FGKKEKGRPGQTGKE-ALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEAR 869
            FGKKEKGR  Q  ++ A G   +++++ S Q+ +  +KLG QAEK+R+L+KKH+LLE+AR
Sbjct: 277  FGKKEKGRLIQLSRDGATGHVLLTDSEFSMQEPMVPAKLGTQAEKDRRLKKKHQLLEDAR 336

Query: 870  RQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPL 929
            R+G+PFAQWDGPTVV WLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISN L
Sbjct: 337  RKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNAL 396

Query: 930  HRLKLRLAIQEIMSLTSPSAPPTSRT------------------------------TLAY 959
            HRLKLRLAIQE++SLTSPSAPPTSRT                              TLAY
Sbjct: 397  HRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLETSTKTDSEEGSWAQTLAY 456

Query: 960  GDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQC 1019
            GDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLR  LKMVDSFHR S Q 
Sbjct: 457  GDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQY 516

Query: 1020 GIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHG 1079
            GIMCL+RLNYDRKELE++REESQ EIKDVLVW+ND+V+ W+ SIGL++YA NL ESGVHG
Sbjct: 517  GIMCLKRLNYDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHG 576

Query: 1080 ALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPS 1139
            ALLALDE FD + LAL+LQIPTQNTQAR V+EREFNNLL +GTDR+ D+ DDK FRRAPS
Sbjct: 577  ALLALDENFDHNTLALILQIPTQNTQARQVMEREFNNLLALGTDRKLDDGDDKVFRRAPS 636

Query: 1140 WRKKFRPKDIR---GLAAGSAETLPANFRVTS--SMSSPSMQPKKMQMDGN 1185
            WRK+FRP++     G+ + SAETLPA FRV++  ++  P   PKK+  + +
Sbjct: 637  WRKRFRPREHHGRGGMLSASAETLPAGFRVSTLGTLQPPPAPPKKIMPEAH 687


>gi|157837985 kazrin isoform E [Homo sapiens]
          Length = 775

 Score =  202 bits (513), Expect = 2e-51
 Identities = 193/678 (28%), Positives = 300/678 (44%), Gaps = 101/678 (14%)

Query: 463  QLHLKERMAALEDKNSLLREV-ESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASL 521
            Q+ L+E ++ L+++  LLR++ E   K LEE+Q  K   VL+   LR +L     +   L
Sbjct: 75   QVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQ---KEQEL 131

Query: 522  HHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRD-----EPSKVQT---- 572
               +  L ++   R  +    TD  S    L    + R   LRD     E  + ++    
Sbjct: 132  ARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAV 191

Query: 573  ---------LNEQDWERAQQASVLANVAQAFESDADVSDG---EDDRDTLLSSVDLLSPS 620
                     L  + WE  +QA    + A A  S  D+ D    E + +  ++   L + +
Sbjct: 192  KALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLT 251

Query: 621  GQADA-HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMS 679
                  H+LAM  +  L+  N+E  ++Q +   T    +  ++   S             
Sbjct: 252  KDVPKRHSLAMPGETVLNG-NQEW-VVQADLPLTAAIRQSQQTLYHSH------------ 297

Query: 680  SIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCE 739
              PP+PA   A    P   R  P  I  + A E DR                        
Sbjct: 298  --PPHPADRQAVRVSPCHSRQ-PSVISDASAAEGDR------------------------ 330

Query: 740  TSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNP--SSSNSSQDSLHKA 797
            +S PS   + R    H+   H++ + D      S G     + NP   S    +D   K 
Sbjct: 331  SSTPSDINSPR----HR--THSLCNGD------SPGPVQKNLHNPIVQSLEDLEDQKRKK 378

Query: 798  PKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRK 857
             K+K    SI R+F + ++ +    G      +  S T  S      LS   G+ + +R 
Sbjct: 379  KKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQS------LSLSEGEEQMDRL 432

Query: 858  LQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDT 917
             Q   EL+        P + W   TV  WLE+ + MP  YV AC  NVKSG ++ +LSD 
Sbjct: 433  QQV--ELVRTT-----PMSHWKAGTVQAWLEVVMAMPM-YVKACTENVKSGKVLLSLSDE 484

Query: 918  EIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGL 977
            ++Q  +G+ + LHR KLRLAI++     +       R+     +++H W+   WL  +GL
Sbjct: 485  DLQLGLGVCSSLHRRKLRLAIEDYRDAEA------GRSLSKAAELDHHWVAKAWLNDIGL 538

Query: 978  PQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERK 1037
             QY   F   LVD RML+ L K+DL   L +   FH+ S   GI  L ++N+ R+ L+ +
Sbjct: 539  SQYSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQER 598

Query: 1038 REESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLL 1097
            R   +++  D +VW+N RV++W+  I LKEYA+NL  SGVHGA+L L+ TF+  A+A  L
Sbjct: 599  RARCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATAL 658

Query: 1098 QIPTQNTQARAVLEREFN 1115
             IP+     R  L  E +
Sbjct: 659  GIPSGKHILRRHLAEEMS 676



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 39/179 (21%), Positives = 80/179 (44%), Gaps = 21/179 (11%)

Query: 246 EEDLAKVIELQEIISKQSREQ-----------SQMKERLASLSSHVTELEEDLDTARKDL 294
           +E++  + +++E+++K   E            ++++ +LA     +   +E L   + D 
Sbjct: 86  QEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATELRVQLAQKEQELARAKEALQAMKADR 145

Query: 295 IKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKD 354
            + +   T L   +++  A  E  EE++    + Y   ++E+       D ++     KD
Sbjct: 146 KRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNYEQHRKES------EDAVKALAKEKD 199

Query: 355 SMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELA---QRVAALSK-AEERH 409
            + R+  +  RQ +E  + A     Q   K   + E+EAELA   Q +A L+K   +RH
Sbjct: 200 LLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRH 258



 Score = 34.3 bits (77), Expect = 0.73
 Identities = 36/137 (26%), Positives = 64/137 (46%), Gaps = 16/137 (11%)

Query: 360 TEDKNRQLQERLELAEQ--KLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLR 417
           T  +N QL  ++ L E+  +LQ+ +     + E+ A+  +        E + G   E L 
Sbjct: 65  TNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLE--------ESQGGKSSEVLS 116

Query: 418 --QMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALED 475
             ++  QL +K QEL RA++  +  +   KRL      L+S+  ++L   L+ R   L D
Sbjct: 117 ATELRVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQM-QQLYATLESREEQLRD 175

Query: 476 KNSLLREVESAKKQLEE 492
               +R  E  +K+ E+
Sbjct: 176 ---FIRNYEQHRKESED 189


>gi|170784854 PTPRF interacting protein, binding protein 2 (liprin
            beta 2) [Homo sapiens]
          Length = 876

 Score =  170 bits (430), Expect = 9e-42
 Identities = 206/829 (24%), Positives = 336/829 (40%), Gaps = 110/829 (13%)

Query: 304  LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDK 363
            L  D+R A+   E  +ER   L      +Q    +   + +  E  ++    ++  +   
Sbjct: 53   LIEDLRLALEMLELPQERAALL------SQIPGPTAAYIKEWFEESLSQ---VNHHSAAS 103

Query: 364  NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQL 423
            N   QERL   E   +  + +   L +      +++  L    E H   + +L   E  L
Sbjct: 104  NETYQERLARLEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGH---QVKLNAAEEML 160

Query: 424  EEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREV 483
            +   QEL      E    +    +S+   KL+    E+ +   K+R A       LL+E+
Sbjct: 161  Q---QELLSRTSLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKA-----EELLQEL 212

Query: 484  ESAKKQLEETQHDKDQLVLNIEALRAEL----DHMRLRGASLHHGRPHLGSVPDFRFPMA 539
               K ++EE +++++Q    ++A +AE+    + + L+ A +      L          +
Sbjct: 213  RHLKIKVEELENERNQYEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALH---S 269

Query: 540  DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDAD 599
            + HT+       L+   +  L A           NE    R ++ + L N  +  +    
Sbjct: 270  ESHTERDQEIQRLKMGMETLLLA-----------NEDKDRRIEELTGLLNQYRKVKEIVM 318

Query: 600  VSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEE 659
            V+ G  +R     S++   P G            E+L       R             + 
Sbjct: 319  VTQGPSERTL---SINEEEPEGGFSKWNATNKDPEELFKQEMPPRCSSPTVGPPPLPQKS 375

Query: 660  IESRVGSGSLDNLGRFRS------MSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREV 713
            +E+R       +L   RS      M    P+P        P  S      + P  P    
Sbjct: 376  LETRAQKKLSCSLEDLRSESVDKCMDGNQPFPVLE-----PKDSPFLAEHKYPTLP---- 426

Query: 714  DRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNS 773
               G ++   P+ E  +   T  + + +  S    LRL     G   T    D+     S
Sbjct: 427  ---GKLSGATPNGEAAKSPPTICQPDATGSS---LLRLRDTESGWDDTAVVNDLSS--TS 478

Query: 774  TGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVS 833
            +G++ GP S P + +  ++        KGIK   G++       R  Q+G          
Sbjct: 479  SGTESGPQS-PLTPDGKRNP-------KGIKKFWGKI-------RRTQSG---------- 513

Query: 834  ETDNSSQDALGLSKL---GGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELW 890
               N   D LG+++    G +A    +L +  +   +      PFAQW    V  WLE +
Sbjct: 514  ---NFYTDTLGMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCAWLEDF 570

Query: 891  VGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAP 950
             G+ A YV   R  V SG  +   +  ++++E+GI +PLHR KL LA++ I      +  
Sbjct: 571  -GL-AQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAI------NTK 622

Query: 951  PTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVD 1010
               ++ L    ++H W+   WL  +GLPQY+  F E  VD RML +LT  DL   LK+  
Sbjct: 623  QEEKSAL----LDHIWV-TRWLDDIGLPQYKDQFHESRVDGRMLQYLTVNDLLF-LKVTS 676

Query: 1011 SFHRNSFQCGIMCLRRLNYDRKELERK-REESQSEIKDVLVWSNDRVIRWILSIGLKEYA 1069
              H  S +C I  L    ++   L R+  +ES     +V+ WSN RV+ W+ S+ L EYA
Sbjct: 677  QLHHLSIKCAIHVLHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYA 736

Query: 1070 NNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLL 1118
             NL  SGVHG L+ L+  F    LA+LL IP Q T  R  L  +FN L+
Sbjct: 737  PNLRGSGVHGGLIILEPRFTGDTLAMLLNIPPQKTLLRRHLTTKFNALI 785



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 54/277 (19%), Positives = 111/277 (40%), Gaps = 46/277 (16%)

Query: 247 EDLAKVIELQEIISKQSREQSQM------------KERLASLSSHVTELEEDLDTARKDL 294
           EDL   +E+ E+  +++   SQ+            +E L+ ++ H     E   T ++ L
Sbjct: 55  EDLRLALEMLELPQERAALLSQIPGPTAAYIKEWFEESLSQVNHHSAASNE---TYQERL 111

Query: 295 IKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKD 354
            + E     L   V     Q E   E+I  LE   +  +     ++   + L+ E+ ++ 
Sbjct: 112 ARLEGDKESLILQVSVLTDQVEAQGEKIRDLE---VCLEGHQVKLNAAEEMLQQELLSRT 168

Query: 355 SMHRQT-----------------EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQ 397
           S+  Q                  E + R+ +E+   AE+ LQ+       + E+E E  Q
Sbjct: 169 SLETQKLDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVEELENERNQ 228

Query: 398 RVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE 457
               L   +     ++E++   +A++E  + +L R       +E H +R          +
Sbjct: 229 YEWKLKATKAEVAQLQEQVALKDAEIERLHSQLSRTAALH--SESHTER---------DQ 277

Query: 458 SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQ 494
             +RL++ ++  + A EDK+  + E+     Q  + +
Sbjct: 278 EIQRLKMGMETLLLANEDKDRRIEELTGLLNQYRKVK 314


>gi|29294627 PTPRF interacting protein binding protein 1 isoform 1
            [Homo sapiens]
          Length = 1005

 Score =  159 bits (402), Expect = 2e-38
 Identities = 216/925 (23%), Positives = 377/925 (40%), Gaps = 140/925 (15%)

Query: 247  EDLAKVIELQEIISKQSRE----QSQMKERLASLSSHVTE--LEEDLDTARKDLIKSEEM 300
            EDL  ++E+ E   K+        S  +  +  L S +T   L  + D  ++ L + E  
Sbjct: 53   EDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLEND 112

Query: 301  NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
               L   V     Q E   E+I  LE      +     V+   + L+ E+ ++ S+  Q 
Sbjct: 113  KESLVLQVSVLTDQVEAQGEKIRDLE---FCLEEHREKVNATEEMLQQELLSRTSLETQK 169

Query: 361  EDKNRQLQE-RLELA---------EQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHG 410
             D   ++   +L+L          E K + T    + + ++  ++++  +   + E++  
Sbjct: 170  LDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLK 229

Query: 411  NIEERLRQMEAQLEEKNQELQRARQRE--KMNEEHNKRLS--DTVDKLLSESN---ERLQ 463
            + ++ L  ++ QLEEK  E++R +++   KM  E  + +   +   K L E N   ++++
Sbjct: 230  STKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDENFKKKLKEKNIEVQKMK 289

Query: 464  LHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASL-- 521
              ++  MAA E+K+   R++E  ++ L   +  +D +VL       + ++  L  +S   
Sbjct: 290  KAVESLMAANEEKD---RKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEELLNSSSIS 346

Query: 522  ----HHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDE-PSKVQTLNEQ 576
                  G   L   P     M     D ++TS     P++     L+   PS +      
Sbjct: 347  SLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSV----PEEFHTTILQVSIPSLLPATVSM 402

Query: 577  DWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSV------DLLSPSGQADAHTLAM 630
              E ++++ +      +FE        E+D + +L +       D L  S    + +L  
Sbjct: 403  --ETSEKSKLTPKPETSFE--------ENDGNIILGATVDTQLCDKLLTSSLQKSSSLGN 452

Query: 631  MLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLA 690
            + +E  D   + I+   E++   E R                       ++PP P     
Sbjct: 453  LKKETSDGEKETIQKTSEDRAPAESRP--------------------FGTLPPRPPGQDT 492

Query: 691  SSSPPGSGRSTPRRIPHSPAREVDRL--GVMTLLPPSREEVRDDKTTIKCETSPPSSPRA 748
            S      G    R++  S  R   ++     T   P+ +  R        ET        
Sbjct: 493  SMDDNPFGT---RKVRSSFGRGFFKIKSNKRTASAPNLDRKRSASAPTLAETEK------ 543

Query: 749  LRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIG 808
                        T  H D+       G+   P    S  NS       +P  K     I 
Sbjct: 544  -----------ETAEHLDL------AGASSRP--KDSQRNSPFQIPPPSPDSKKKSRGIM 584

Query: 809  RLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGG-QAEKNRKLQKKHELLEE 867
            +LFGK  +            Q+     D+ S+      K GG +A    +L    +L + 
Sbjct: 585  KLFGKLRRS-----------QSTTFNPDDMSEPEF---KRGGTRATAGPRLGWSRDLGQS 630

Query: 868  ARRQGLPFAQWDGPTVVVWL-ELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGIS 926
                 +PFA+W    V  WL E  +G    Y+ + +  + SG  +   S  ++++E+GI 
Sbjct: 631  NSDLDMPFAKWTKEQVCNWLMEQGLGS---YLNSGKHWIASGQTLLQASQQDLEKELGIK 687

Query: 927  NPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFME 986
            + LHR KL+LA+Q + S    +          +G ++  W+   WL  +GLPQY++ F E
Sbjct: 688  HSLHRKKLQLALQALGSEEETN----------HGKLDFNWV-TRWLDDIGLPQYKTQFDE 736

Query: 987  CLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERK-REESQSEI 1045
              VD RML ++T  DL   LK+V   H  S +  I  LR  N++   L R+  +E+    
Sbjct: 737  GRVDGRMLHYMTVDDLLS-LKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAP 795

Query: 1046 KDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQ 1105
             +V  W+N RV+ W+ S+ L EYA NL  SGVHG L+ L+  F+   +A LL IP   T 
Sbjct: 796  SEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTL 855

Query: 1106 ARAVLEREFNNLLVMGTDRRFDEDD 1130
             R  L   FN  L++G + +  + D
Sbjct: 856  LRRHLATHFN--LLIGAEAQHQKRD 878



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 175/850 (20%), Positives = 327/850 (38%), Gaps = 162/850 (19%)

Query: 202 ELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISK 261
           E+M   E+   +  + D   +   E   +  T+G    +G + ++E LA++   +E +  
Sbjct: 60  EMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDV-YQERLARLENDKESLVL 118

Query: 262 QSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM-------NTKLQRDVREAMAQ 314
           Q    S + +++ +    + +LE  L+  R+ +  +EEM        T L+    + MA+
Sbjct: 119 QV---SVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAE 175

Query: 315 KEDMEERITTLEKRYLAAQREATS----VHDLNDKLENEIANKDSMHRQTEDKNRQLQER 370
             +++ ++T +EK  L  + +       + ++ND L  +++  DS   Q E K +  ++ 
Sbjct: 176 ISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEIND-LRLKVSEMDSERLQYEKKLKSTKDE 234

Query: 371 LELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQEL 430
           L   +++L++   + + L E           + K +     I +R    + +L+EKN E+
Sbjct: 235 LASLKEQLEEKESEVKRLQE---------KLVCKMKGEGVEIVDRDENFKKKLKEKNIEV 285

Query: 431 QRARQREK----MNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESA 486
           Q+ ++  +     NEE ++++ D    L              R   ++D   L +  +  
Sbjct: 286 QKMKKAVESLMAANEEKDRKIEDLRQCL-------------NRYKKMQDTVVLAQGKKGK 332

Query: 487 KKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSY 546
             + EE        +LN  ++ + LD           G   L   P     M     D +
Sbjct: 333 DGEYEE--------LLNSSSISSLLD---------AQGFSDLEKSPSPTPVMGSPSCDPF 375

Query: 547 STSAVLRRPQKGRLAALR-DEPSKVQTLNEQDWERAQQASVLANVAQAF-ESDADVSDGE 604
           +TS     P++     L+   PS +        E ++++ +      +F E+D ++  G 
Sbjct: 376 NTSV----PEEFHTTILQVSIPSLLPA--TVSMETSEKSKLTPKPETSFEENDGNIILGA 429

Query: 605 DDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQR-------- 656
              DT L   D L  S    + +L  + +E  D   + I+   E++   E R        
Sbjct: 430 -TVDTQL--CDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPR 486

Query: 657 --------------AEEIESRVGSG-----------SLDNLGRFRSMSS-----IPPYPA 686
                           ++ S  G G           S  NL R RS S+          A
Sbjct: 487 PPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLDRKRSASAPTLAETEKETA 546

Query: 687 SSL----ASSSPPGSGRSTPRRI-PHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETS 741
             L    ASS P  S R++P +I P SP  +    G+M L    R   R   TT      
Sbjct: 547 EHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLR---RSQSTTF----- 598

Query: 742 PPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKK 801
              +P  +      +G             R + G + G   +   SNS  D     P  K
Sbjct: 599 ---NPDDMSEPEFKRGG-----------TRATAGPRLGWSRDLGQSNSDLD----MPFAK 640

Query: 802 GIKSSIGRLFGKKEKGRPGQTGKE--ALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQ 859
             K  +     ++  G    +GK   A GQ  +  +    +  LG+      +   +KLQ
Sbjct: 641 WTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIK----HSLHRKKLQ 696

Query: 860 KKHELL--EEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDT 917
              + L  EE    G     W    V  WL+  +G+P +        V  G ++  ++  
Sbjct: 697 LALQALGSEEETNHGKLDFNW----VTRWLD-DIGLPQYKTQFDEGRV-DGRMLHYMTVD 750

Query: 918 EIQREIGISNPLHRLKLRLAIQEI-MSLTSPSA---PPTSRTTLAYGDMNHEWIGN---E 970
           ++   + + + LH L ++ AIQ + ++   P+     P+   T+A  ++  +W  +   E
Sbjct: 751 DL-LSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEV-QKWTNHRVME 808

Query: 971 WLPSLGLPQY 980
           WL S+ L +Y
Sbjct: 809 WLRSVDLAEY 818



 Score = 35.0 bits (79), Expect = 0.43
 Identities = 56/282 (19%), Positives = 114/282 (40%), Gaps = 31/282 (10%)

Query: 65  QGKLHEVGHERDSLQRQLNTALPQEFAALTK--ELNVCREQLLEREEEIAELKAER--NN 120
           Q +L  + ++++SL  Q++    Q  A   K  +L  C E+  E+     E+  +   + 
Sbjct: 103 QERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSR 162

Query: 121 TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRE 180
           T L  + L+ +       L++T V++          + E L  ++ + +    + E   E
Sbjct: 163 TSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGL--IQEINDLRLKVSEMDSE 220

Query: 181 RLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
           RL+         E++L +T  EL  LKEQ  +K++      ++   QE       K   +
Sbjct: 221 RLQY--------EKKLKSTKDELASLKEQLEEKES------EVKRLQEKLVC---KMKGE 263

Query: 241 GSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
           G         ++++  E   K+ +E++   +++      +    E+ D   +DL +    
Sbjct: 264 G--------VEIVDRDENFKKKLKEKNIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNR 315

Query: 301 NTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDL 342
             K+Q  V  A  +K    E    L    +++  +A    DL
Sbjct: 316 YKKMQDTVVLAQGKKGKDGEYEELLNSSSISSLLDAQGFSDL 357


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  108 bits (270), Expect = 3e-23
 Identities = 117/477 (24%), Positives = 211/477 (44%), Gaps = 55/477 (11%)

Query: 50   LLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREE 109
            LL   R+ +E  A  + +L +    +   + +L   L Q+ + LT+E N+ +EQL    E
Sbjct: 844  LLQVTRQEEEMQA-KEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETE 901

Query: 110  EIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFE 169
              AE  AE    RL  +  E     HE   R+     + +   G   + E  K  + + +
Sbjct: 902  LYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLD 954

Query: 170  HHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNN----QKKTLTDGVLDIN- 224
              + L+E+   R ++ LE+ +  E ++     E++++ +QNN    ++K L + + D+  
Sbjct: 955  LEEQLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 225  ---HEQENTPSTSGKRSSDGSLSHE------EDLAKVIELQEIISKQSREQSQMKERLAS 275
                E+E   + +  ++   S+  E      ++     EL+++  K   + S   E++A 
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 276  LSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQRE 335
            L + + EL+  L        K EE+   L R + + +AQK +  ++I  LE         
Sbjct: 1074 LQAQIAELKMQLAK------KEEELQAALAR-LDDEIAQKNNALKKIRELEGH------- 1119

Query: 336  ATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL 395
               + DL + L++E A ++    + E + R L E LE  + +L+ TL    T  E+ A+ 
Sbjct: 1120 ---ISDLQEDLDSERAARN----KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 396  AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL 455
             Q V  L KA      ++E  R  EAQ++E  Q+  +A +      E  KR    +DK  
Sbjct: 1173 EQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-- 1224

Query: 456  SESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELD 512
              + + L+    +    L       +EVE  KK+LE    +      + E  RAEL+
Sbjct: 1225 --NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 117/528 (22%), Positives = 225/528 (42%), Gaps = 78/528 (14%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAA----LTK 95
            +    EE+    D L +T+  L   Q +L ++  + D+ QRQL + L ++       L +
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAE 1459

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVS 155
            E N+  +   ER+   AE + +      L   LE  +   E  L  T    +A+    VS
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVS 1518

Query: 156  SEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATH--------------- 200
            S+ +V K +  L +  +AL+ ++ E ++  LE    LE+EL AT                
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKG 1574

Query: 201  ---KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE--EDLAKVIEL 255
               ++L    EQN +K+      L   HE E       K+ +  + + +  E   K +EL
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQL---HEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 256  QEIISKQSREQS--QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMA 313
            Q   + + RE++  Q+++  A +     ELE D   +R ++  + + N K          
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEK---------- 1680

Query: 314  QKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
            + + +E  +  L++   AA+R         ++L  E+A+  S     +D+ R+L+ R+  
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQ-R 432
             E++L++     E + +   +  Q+   LS       +  ++      QLE +N+EL+ +
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 433  ARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA---LEDKNSLLRE------- 482
              + E   +   K     ++  +++  E+++   +E+ AA   L+ K+  L+E       
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860

Query: 483  ------------------VESAKKQLEETQHDKDQLVLNIEALRAELD 512
                              V+  K+QLEE + +  ++  N   L+ ELD
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 101/527 (19%), Positives = 200/527 (37%), Gaps = 99/527 (18%)

Query: 83   NTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMT 142
            N  L +E   L + ++     L E EE+   L   +N    ++  LE  + + E+S R  
Sbjct: 994  NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQE 1052

Query: 143  VVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKE 202
            + K + +     S   E +  L++     K    K  E L+ AL R   L++E+   +  
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNA 1109

Query: 203  LMILKE---------------------QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDG 241
            L  ++E                        QK+ L + +  +  E E+T  ++  +    
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 242  SLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
            +   +E       L E       +  +M+++ A     +TE  E    A+ +L K+++  
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 302  TKLQRDV-----------REAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
             K   D+           +E   +K+ +E ++  L+ +    +R    ++D   KL+NE+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 351  ANKDSMHRQTEDK-----------NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
             +   M  + E K           + QLQ+  EL +++ +Q L  +  L ++E E     
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 400  AALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKL----- 454
              L +  E   N+E  +  +  QL +  ++LQ      +  EE  KR    ++ L     
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 455  --------LSESNERLQLHLKERMAALEDKNSLLREVESAKKQ----------------- 489
                    L ++  RLQ  L + +  L+++  L+  +E  +++                 
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 490  ----------------------LEETQHDKDQLVLNIEALRAELDHM 514
                                  LEE    K++L    + L+AE++ +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 129/564 (22%), Positives = 230/564 (40%), Gaps = 84/564 (14%)

Query: 140  RMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGAT 199
            R    KRQ Q  A    +      LK        L  KV+  L+V  +     EEE+ A 
Sbjct: 803  RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-----EEEMQAK 857

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
              EL   KE+  QK       L+  H Q               L+ E++L     LQE +
Sbjct: 858  EDELQKTKERQ-QKAENELKELEQKHSQ---------------LTEEKNL-----LQEQL 896

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
              ++   ++ +E    L++   ELEE L      L + E+   +LQ + ++   Q  D+E
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 320  ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
            E++   E      Q E  +      KLE+EI   D  + +   + + L+ER+      L 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 380  QTLRKAETLPEV----EAELAQRVAALSKAEERHGNIEERLRQMEA-------------- 421
            +   KA+ L ++    E+ +++    L K E+    +E+  R++E               
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 422  -------QLEEKNQELQRARQR--EKMNEEHN--KRLSDTVDKLLSESNERLQLHLKERM 470
                   QL +K +ELQ A  R  +++ +++N  K++ + ++  +S+  E L      R 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARN 1135

Query: 471  AALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGS 530
             A + K  L  E+E+ K +LE+T  D       + A R E +   L+ A     R H   
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTL-DSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQ 1193

Query: 531  VPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANV 590
            V + R         + +   +  + ++ + A    + +K QTL +++ + A +  VL   
Sbjct: 1194 VQEMR------QKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQA 1246

Query: 591  ------------AQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQE---Q 635
                        AQ  E  +  SDGE  R  L   V  L    Q +  ++  ML E   +
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL----QNEVESVTGMLNEAEGK 1302

Query: 636  LDAINKEIRLIQEEKENTEQRAEE 659
               + K++  +  + ++T++  +E
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQE 1326



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 82/667 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR--- 101
            EE + L   L +T ++ A  Q    E+  +R+     L  AL +E  +   ++   R   
Sbjct: 1146 EELEALKTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 102  ----EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSE 157
                E+L E+ E+    KA  +  +  LE     ++   R L     + + +    + ++
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK-LEAQ 1260

Query: 158  VEVLKALKSLFEHHKA-LDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTL 216
            V+ L++  S  E  +A L++KV +          +L E  G   K    +   ++Q +  
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD- 1319

Query: 217  TDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE----LQEIISKQSREQSQMKER 272
            T  +L     Q+   ST  ++  +   S ++ L + +E    L+  IS  + + S  K++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 273  LASLSSHVTELEEDLDTARKDLI--------------KSEEMNTKLQRDVREAMAQKEDM 318
            L   +S V  LEE     +K++               K E+   +LQ+++ + +   ++ 
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 319  EERITTLEKRY------LAAQREATSVH-DLNDKLENEIANKDSMHRQTEDKNRQLQERL 371
             + ++ LEK+       LA ++  +S + D  D+ E E   K++   +     R L+E L
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL 1496

Query: 372  ELAEQKLQQTLR----KAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKN 427
            E A+++L++T +    + E L   + ++ + V  L K++     +E ++ +M+ QLEE  
Sbjct: 1497 E-AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELE 1552

Query: 428  QELQRARQREKMNEEHN--------KRLSDTVDKLLSESNERLQLHLKERMAALEDKNSL 479
             ELQ A +  K+  E N        +R     D+   E   +LQ  L E    LED+   
Sbjct: 1553 DELQ-ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611

Query: 480  LREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA 539
                 +AKK+LE    D     L ++A  A    ++ R  ++   R     + DF+  + 
Sbjct: 1612 RALAAAAKKKLEGDLKD-----LELQADSA----IKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 540  DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDAD 599
            D             R  +  + A   E  K     E D  + Q+    A  A+  ++D +
Sbjct: 1663 DA------------RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK-QADLE 1709

Query: 600  VSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEE 659
              +  ++  + LS  + L    +     +A  L+E+L+     +  + +      Q+AE+
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768

Query: 660  IESRVGS 666
            + + + +
Sbjct: 1769 LSNELAT 1775



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 85/425 (20%), Positives = 169/425 (39%), Gaps = 53/425 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ---EFAALTKELNVCR 101
            EE +R    L+   E L  ++  + +  HE +  +R L T + +   +   L  EL    
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559

Query: 102  EQLLEREEEIAELKAE----------------RNNTRLLLEH-LECLVSRHERSLRMTVV 144
            +  L  E  +  LK +                R   R L E+  E    R +R+L     
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619

Query: 145  KR--------QAQSPAGVSSEVEVLKALKSL----------FEHHKALDEKVRERLRVAL 186
            K+        + Q+ + +    E +K L+ L           E  +A  +++    +   
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 187  ERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQ---ENTPSTSGKRSSDGSL 243
            ++   LE +L    ++L   +    Q         D+  E+   E   S SG+ +     
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQA--------DLEKEELAEELASSLSGRNALQDEK 1731

Query: 244  SHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTK 303
               E  A++ +L+E + ++      M +R+   +    +L  +L T R    K+E    +
Sbjct: 1732 RRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789

Query: 304  LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDK 363
            L+R  +E  ++  +ME  + +  K  +AA      +  L +++E E   K +  +  + K
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQK 1847

Query: 364  NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQL 423
            +++L+E L   E + +   +  E   +  A + Q    L +AEE    I    R+++ +L
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 424  EEKNQ 428
            +E  +
Sbjct: 1908 DEATE 1912



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 70/323 (21%), Positives = 131/323 (40%), Gaps = 27/323 (8%)

Query: 42   SMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR 101
            S ++ R+  +  LR+ Q  +   Q +L +    RD +     TA   E  A + E +   
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEAD--- 1688

Query: 102  EQLLEREEEIAELKAERNNTRLLLEHL--ECLVSRHERSLRMTVVKRQAQSPAGVSSEVE 159
              L++ +E++A  +  R    L  E L  E   S   R+      +R     A +  E+E
Sbjct: 1689 --LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746

Query: 160  VLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDG 219
              +       + +A+ ++VR+  + A +  + L  E     K     ++   Q K L   
Sbjct: 1747 EEQG------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 220  VLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSH 279
            +    HE E    +  K S+  +L      AK+ +L+E + +++RE+    + L      
Sbjct: 1801 L----HEMEGAVKSKFK-STIAALE-----AKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 280  VTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSV 339
            + E+   ++  RK   + +E   K    V++   Q E+ EE    +       QRE    
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910

Query: 340  HDLNDKLENEI-ANKDSMHRQTE 361
             + N+ +  E+ A K  + R  E
Sbjct: 1911 TESNEAMGREVNALKSKLRRGNE 1933


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  108 bits (270), Expect = 3e-23
 Identities = 117/477 (24%), Positives = 211/477 (44%), Gaps = 55/477 (11%)

Query: 50   LLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREE 109
            LL   R+ +E  A  + +L +    +   + +L   L Q+ + LT+E N+ +EQL    E
Sbjct: 851  LLQVTRQEEEMQA-KEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETE 908

Query: 110  EIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFE 169
              AE  AE    RL  +  E     HE   R+     + +   G   + E  K  + + +
Sbjct: 909  LYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLD 961

Query: 170  HHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNN----QKKTLTDGVLDIN- 224
              + L+E+   R ++ LE+ +  E ++     E++++ +QNN    ++K L + + D+  
Sbjct: 962  LEEQLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 225  ---HEQENTPSTSGKRSSDGSLSHE------EDLAKVIELQEIISKQSREQSQMKERLAS 275
                E+E   + +  ++   S+  E      ++     EL+++  K   + S   E++A 
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 276  LSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQRE 335
            L + + EL+  L        K EE+   L R + + +AQK +  ++I  LE         
Sbjct: 1081 LQAQIAELKMQLAK------KEEELQAALAR-LDDEIAQKNNALKKIRELEGH------- 1126

Query: 336  ATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL 395
               + DL + L++E A ++    + E + R L E LE  + +L+ TL    T  E+ A+ 
Sbjct: 1127 ---ISDLQEDLDSERAARN----KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 396  AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL 455
             Q V  L KA      ++E  R  EAQ++E  Q+  +A +      E  KR    +DK  
Sbjct: 1180 EQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-- 1231

Query: 456  SESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELD 512
              + + L+    +    L       +EVE  KK+LE    +      + E  RAEL+
Sbjct: 1232 --NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 117/528 (22%), Positives = 225/528 (42%), Gaps = 78/528 (14%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAA----LTK 95
            +    EE+    D L +T+  L   Q +L ++  + D+ QRQL + L ++       L +
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAE 1466

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVS 155
            E N+  +   ER+   AE + +      L   LE  +   E  L  T    +A+    VS
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVS 1525

Query: 156  SEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATH--------------- 200
            S+ +V K +  L +  +AL+ ++ E ++  LE    LE+EL AT                
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKG 1581

Query: 201  ---KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE--EDLAKVIEL 255
               ++L    EQN +K+      L   HE E       K+ +  + + +  E   K +EL
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQL---HEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 256  QEIISKQSREQS--QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMA 313
            Q   + + RE++  Q+++  A +     ELE D   +R ++  + + N K          
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEK---------- 1687

Query: 314  QKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
            + + +E  +  L++   AA+R         ++L  E+A+  S     +D+ R+L+ R+  
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQ-R 432
             E++L++     E + +   +  Q+   LS       +  ++      QLE +N+EL+ +
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 433  ARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA---LEDKNSLLRE------- 482
              + E   +   K     ++  +++  E+++   +E+ AA   L+ K+  L+E       
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867

Query: 483  ------------------VESAKKQLEETQHDKDQLVLNIEALRAELD 512
                              V+  K+QLEE + +  ++  N   L+ ELD
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 101/527 (19%), Positives = 200/527 (37%), Gaps = 99/527 (18%)

Query: 83   NTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMT 142
            N  L +E   L + ++     L E EE+   L   +N    ++  LE  + + E+S R  
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQE 1059

Query: 143  VVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKE 202
            + K + +     S   E +  L++     K    K  E L+ AL R   L++E+   +  
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNA 1116

Query: 203  LMILKE---------------------QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDG 241
            L  ++E                        QK+ L + +  +  E E+T  ++  +    
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 242  SLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
            +   +E       L E       +  +M+++ A     +TE  E    A+ +L K+++  
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 302  TKLQRDV-----------REAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
             K   D+           +E   +K+ +E ++  L+ +    +R    ++D   KL+NE+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 351  ANKDSMHRQTEDK-----------NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
             +   M  + E K           + QLQ+  EL +++ +Q L  +  L ++E E     
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 400  AALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKL----- 454
              L +  E   N+E  +  +  QL +  ++LQ      +  EE  KR    ++ L     
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 455  --------LSESNERLQLHLKERMAALEDKNSLLREVESAKKQ----------------- 489
                    L ++  RLQ  L + +  L+++  L+  +E  +++                 
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 490  ----------------------LEETQHDKDQLVLNIEALRAELDHM 514
                                  LEE    K++L    + L+AE++ +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 129/564 (22%), Positives = 230/564 (40%), Gaps = 84/564 (14%)

Query: 140  RMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGAT 199
            R    KRQ Q  A    +      LK        L  KV+  L+V  +     EEE+ A 
Sbjct: 810  RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-----EEEMQAK 864

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
              EL   KE+  QK       L+  H Q               L+ E++L     LQE +
Sbjct: 865  EDELQKTKERQ-QKAENELKELEQKHSQ---------------LTEEKNL-----LQEQL 903

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
              ++   ++ +E    L++   ELEE L      L + E+   +LQ + ++   Q  D+E
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 320  ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
            E++   E      Q E  +      KLE+EI   D  + +   + + L+ER+      L 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 380  QTLRKAETLPEV----EAELAQRVAALSKAEERHGNIEERLRQMEA-------------- 421
            +   KA+ L ++    E+ +++    L K E+    +E+  R++E               
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 422  -------QLEEKNQELQRARQR--EKMNEEHN--KRLSDTVDKLLSESNERLQLHLKERM 470
                   QL +K +ELQ A  R  +++ +++N  K++ + ++  +S+  E L      R 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARN 1142

Query: 471  AALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGS 530
             A + K  L  E+E+ K +LE+T  D       + A R E +   L+ A     R H   
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTL-DSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQ 1200

Query: 531  VPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANV 590
            V + R         + +   +  + ++ + A    + +K QTL +++ + A +  VL   
Sbjct: 1201 VQEMR------QKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQA 1253

Query: 591  ------------AQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQE---Q 635
                        AQ  E  +  SDGE  R  L   V  L    Q +  ++  ML E   +
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL----QNEVESVTGMLNEAEGK 1309

Query: 636  LDAINKEIRLIQEEKENTEQRAEE 659
               + K++  +  + ++T++  +E
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQE 1333



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 82/667 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR--- 101
            EE + L   L +T ++ A  Q    E+  +R+     L  AL +E  +   ++   R   
Sbjct: 1153 EELEALKTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 102  ----EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSE 157
                E+L E+ E+    KA  +  +  LE     ++   R L     + + +    + ++
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK-LEAQ 1267

Query: 158  VEVLKALKSLFEHHKA-LDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTL 216
            V+ L++  S  E  +A L++KV +          +L E  G   K    +   ++Q +  
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD- 1326

Query: 217  TDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE----LQEIISKQSREQSQMKER 272
            T  +L     Q+   ST  ++  +   S ++ L + +E    L+  IS  + + S  K++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 273  LASLSSHVTELEEDLDTARKDLI--------------KSEEMNTKLQRDVREAMAQKEDM 318
            L   +S V  LEE     +K++               K E+   +LQ+++ + +   ++ 
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 319  EERITTLEKRY------LAAQREATSVH-DLNDKLENEIANKDSMHRQTEDKNRQLQERL 371
             + ++ LEK+       LA ++  +S + D  D+ E E   K++   +     R L+E L
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL 1503

Query: 372  ELAEQKLQQTLR----KAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKN 427
            E A+++L++T +    + E L   + ++ + V  L K++     +E ++ +M+ QLEE  
Sbjct: 1504 E-AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELE 1559

Query: 428  QELQRARQREKMNEEHN--------KRLSDTVDKLLSESNERLQLHLKERMAALEDKNSL 479
             ELQ A +  K+  E N        +R     D+   E   +LQ  L E    LED+   
Sbjct: 1560 DELQ-ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618

Query: 480  LREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA 539
                 +AKK+LE    D     L ++A  A    ++ R  ++   R     + DF+  + 
Sbjct: 1619 RALAAAAKKKLEGDLKD-----LELQADSA----IKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 540  DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDAD 599
            D             R  +  + A   E  K     E D  + Q+    A  A+  ++D +
Sbjct: 1670 DA------------RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK-QADLE 1716

Query: 600  VSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEE 659
              +  ++  + LS  + L    +     +A  L+E+L+     +  + +      Q+AE+
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775

Query: 660  IESRVGS 666
            + + + +
Sbjct: 1776 LSNELAT 1782



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 85/425 (20%), Positives = 169/425 (39%), Gaps = 53/425 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ---EFAALTKELNVCR 101
            EE +R    L+   E L  ++  + +  HE +  +R L T + +   +   L  EL    
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566

Query: 102  EQLLEREEEIAELKAE----------------RNNTRLLLEH-LECLVSRHERSLRMTVV 144
            +  L  E  +  LK +                R   R L E+  E    R +R+L     
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

Query: 145  KR--------QAQSPAGVSSEVEVLKALKSL----------FEHHKALDEKVRERLRVAL 186
            K+        + Q+ + +    E +K L+ L           E  +A  +++    +   
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 187  ERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQ---ENTPSTSGKRSSDGSL 243
            ++   LE +L    ++L   +    Q         D+  E+   E   S SG+ +     
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQA--------DLEKEELAEELASSLSGRNALQDEK 1738

Query: 244  SHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTK 303
               E  A++ +L+E + ++      M +R+   +    +L  +L T R    K+E    +
Sbjct: 1739 RRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796

Query: 304  LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDK 363
            L+R  +E  ++  +ME  + +  K  +AA      +  L +++E E   K +  +  + K
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 364  NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQL 423
            +++L+E L   E + +   +  E   +  A + Q    L +AEE    I    R+++ +L
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 424  EEKNQ 428
            +E  +
Sbjct: 1915 DEATE 1919



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 70/323 (21%), Positives = 131/323 (40%), Gaps = 27/323 (8%)

Query: 42   SMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR 101
            S ++ R+  +  LR+ Q  +   Q +L +    RD +     TA   E  A + E +   
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEAD--- 1695

Query: 102  EQLLEREEEIAELKAERNNTRLLLEHL--ECLVSRHERSLRMTVVKRQAQSPAGVSSEVE 159
              L++ +E++A  +  R    L  E L  E   S   R+      +R     A +  E+E
Sbjct: 1696 --LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753

Query: 160  VLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDG 219
              +       + +A+ ++VR+  + A +  + L  E     K     ++   Q K L   
Sbjct: 1754 EEQG------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 220  VLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSH 279
            +    HE E    +  K S+  +L      AK+ +L+E + +++RE+    + L      
Sbjct: 1808 L----HEMEGAVKSKFK-STIAALE-----AKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 280  VTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSV 339
            + E+   ++  RK   + +E   K    V++   Q E+ EE    +       QRE    
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917

Query: 340  HDLNDKLENEI-ANKDSMHRQTE 361
             + N+ +  E+ A K  + R  E
Sbjct: 1918 TESNEAMGREVNALKSKLRRGNE 1940


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  108 bits (270), Expect = 3e-23
 Identities = 117/477 (24%), Positives = 211/477 (44%), Gaps = 55/477 (11%)

Query: 50   LLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREE 109
            LL   R+ +E  A  + +L +    +   + +L   L Q+ + LT+E N+ +EQL    E
Sbjct: 851  LLQVTRQEEEMQA-KEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETE 908

Query: 110  EIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFE 169
              AE  AE    RL  +  E     HE   R+     + +   G   + E  K  + + +
Sbjct: 909  LYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLD 961

Query: 170  HHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNN----QKKTLTDGVLDIN- 224
              + L+E+   R ++ LE+ +  E ++     E++++ +QNN    ++K L + + D+  
Sbjct: 962  LEEQLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020

Query: 225  ---HEQENTPSTSGKRSSDGSLSHE------EDLAKVIELQEIISKQSREQSQMKERLAS 275
                E+E   + +  ++   S+  E      ++     EL+++  K   + S   E++A 
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080

Query: 276  LSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQRE 335
            L + + EL+  L        K EE+   L R + + +AQK +  ++I  LE         
Sbjct: 1081 LQAQIAELKMQLAK------KEEELQAALAR-LDDEIAQKNNALKKIRELEGH------- 1126

Query: 336  ATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL 395
               + DL + L++E A ++    + E + R L E LE  + +L+ TL    T  E+ A+ 
Sbjct: 1127 ---ISDLQEDLDSERAARN----KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179

Query: 396  AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL 455
             Q V  L KA      ++E  R  EAQ++E  Q+  +A +      E  KR    +DK  
Sbjct: 1180 EQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-- 1231

Query: 456  SESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELD 512
              + + L+    +    L       +EVE  KK+LE    +      + E  RAEL+
Sbjct: 1232 --NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1286



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 117/528 (22%), Positives = 225/528 (42%), Gaps = 78/528 (14%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAA----LTK 95
            +    EE+    D L +T+  L   Q +L ++  + D+ QRQL + L ++       L +
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAE 1466

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVS 155
            E N+  +   ER+   AE + +      L   LE  +   E  L  T    +A+    VS
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVS 1525

Query: 156  SEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATH--------------- 200
            S+ +V K +  L +  +AL+ ++ E ++  LE    LE+EL AT                
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKG 1581

Query: 201  ---KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE--EDLAKVIEL 255
               ++L    EQN +K+      L   HE E       K+ +  + + +  E   K +EL
Sbjct: 1582 QFERDLQARDEQNEEKRRQLQRQL---HEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1638

Query: 256  QEIISKQSREQS--QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMA 313
            Q   + + RE++  Q+++  A +     ELE D   +R ++  + + N K          
Sbjct: 1639 QADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEK---------- 1687

Query: 314  QKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
            + + +E  +  L++   AA+R         ++L  E+A+  S     +D+ R+L+ R+  
Sbjct: 1688 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1747

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQ-R 432
             E++L++     E + +   +  Q+   LS       +  ++      QLE +N+EL+ +
Sbjct: 1748 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 433  ARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA---LEDKNSLLRE------- 482
              + E   +   K     ++  +++  E+++   +E+ AA   L+ K+  L+E       
Sbjct: 1808 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1867

Query: 483  ------------------VESAKKQLEETQHDKDQLVLNIEALRAELD 512
                              V+  K+QLEE + +  ++  N   L+ ELD
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1915



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 101/527 (19%), Positives = 200/527 (37%), Gaps = 99/527 (18%)

Query: 83   NTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMT 142
            N  L +E   L + ++     L E EE+   L   +N    ++  LE  + + E+S R  
Sbjct: 1001 NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQE 1059

Query: 143  VVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKE 202
            + K + +     S   E +  L++     K    K  E L+ AL R   L++E+   +  
Sbjct: 1060 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNA 1116

Query: 203  LMILKE---------------------QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDG 241
            L  ++E                        QK+ L + +  +  E E+T  ++  +    
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176

Query: 242  SLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
            +   +E       L E       +  +M+++ A     +TE  E    A+ +L K+++  
Sbjct: 1177 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1236

Query: 302  TKLQRDV-----------REAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
             K   D+           +E   +K+ +E ++  L+ +    +R    ++D   KL+NE+
Sbjct: 1237 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296

Query: 351  ANKDSMHRQTEDK-----------NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
             +   M  + E K           + QLQ+  EL +++ +Q L  +  L ++E E     
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1356

Query: 400  AALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKL----- 454
              L +  E   N+E  +  +  QL +  ++LQ      +  EE  KR    ++ L     
Sbjct: 1357 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 455  --------LSESNERLQLHLKERMAALEDKNSLLREVESAKKQ----------------- 489
                    L ++  RLQ  L + +  L+++  L+  +E  +++                 
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476

Query: 490  ----------------------LEETQHDKDQLVLNIEALRAELDHM 514
                                  LEE    K++L    + L+AE++ +
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 129/564 (22%), Positives = 230/564 (40%), Gaps = 84/564 (14%)

Query: 140  RMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGAT 199
            R    KRQ Q  A    +      LK        L  KV+  L+V  +     EEE+ A 
Sbjct: 810  RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-----EEEMQAK 864

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
              EL   KE+  QK       L+  H Q               L+ E++L     LQE +
Sbjct: 865  EDELQKTKERQ-QKAENELKELEQKHSQ---------------LTEEKNL-----LQEQL 903

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
              ++   ++ +E    L++   ELEE L      L + E+   +LQ + ++   Q  D+E
Sbjct: 904  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963

Query: 320  ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
            E++   E      Q E  +      KLE+EI   D  + +   + + L+ER+      L 
Sbjct: 964  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1023

Query: 380  QTLRKAETLPEV----EAELAQRVAALSKAEERHGNIEERLRQMEA-------------- 421
            +   KA+ L ++    E+ +++    L K E+    +E+  R++E               
Sbjct: 1024 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1083

Query: 422  -------QLEEKNQELQRARQR--EKMNEEHN--KRLSDTVDKLLSESNERLQLHLKERM 470
                   QL +K +ELQ A  R  +++ +++N  K++ + ++  +S+  E L      R 
Sbjct: 1084 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARN 1142

Query: 471  AALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGS 530
             A + K  L  E+E+ K +LE+T  D       + A R E +   L+ A     R H   
Sbjct: 1143 KAEKQKRDLGEELEALKTELEDTL-DSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQ 1200

Query: 531  VPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANV 590
            V + R         + +   +  + ++ + A    + +K QTL +++ + A +  VL   
Sbjct: 1201 VQEMR------QKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQA 1253

Query: 591  ------------AQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQE---Q 635
                        AQ  E  +  SDGE  R  L   V  L    Q +  ++  ML E   +
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL----QNEVESVTGMLNEAEGK 1309

Query: 636  LDAINKEIRLIQEEKENTEQRAEE 659
               + K++  +  + ++T++  +E
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQE 1333



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 82/667 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR--- 101
            EE + L   L +T ++ A  Q    E+  +R+     L  AL +E  +   ++   R   
Sbjct: 1153 EELEALKTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1208

Query: 102  ----EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSE 157
                E+L E+ E+    KA  +  +  LE     ++   R L     + + +    + ++
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK-LEAQ 1267

Query: 158  VEVLKALKSLFEHHKA-LDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTL 216
            V+ L++  S  E  +A L++KV +          +L E  G   K    +   ++Q +  
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD- 1326

Query: 217  TDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE----LQEIISKQSREQSQMKER 272
            T  +L     Q+   ST  ++  +   S ++ L + +E    L+  IS  + + S  K++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1386

Query: 273  LASLSSHVTELEEDLDTARKDLI--------------KSEEMNTKLQRDVREAMAQKEDM 318
            L   +S V  LEE     +K++               K E+   +LQ+++ + +   ++ 
Sbjct: 1387 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446

Query: 319  EERITTLEKRY------LAAQREATSVH-DLNDKLENEIANKDSMHRQTEDKNRQLQERL 371
             + ++ LEK+       LA ++  +S + D  D+ E E   K++   +     R L+E L
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL 1503

Query: 372  ELAEQKLQQTLR----KAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKN 427
            E A+++L++T +    + E L   + ++ + V  L K++     +E ++ +M+ QLEE  
Sbjct: 1504 E-AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELE 1559

Query: 428  QELQRARQREKMNEEHN--------KRLSDTVDKLLSESNERLQLHLKERMAALEDKNSL 479
             ELQ A +  K+  E N        +R     D+   E   +LQ  L E    LED+   
Sbjct: 1560 DELQ-ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1618

Query: 480  LREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA 539
                 +AKK+LE    D     L ++A  A    ++ R  ++   R     + DF+  + 
Sbjct: 1619 RALAAAAKKKLEGDLKD-----LELQADSA----IKGREEAIKQLRKLQAQMKDFQRELE 1669

Query: 540  DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDAD 599
            D             R  +  + A   E  K     E D  + Q+    A  A+  ++D +
Sbjct: 1670 DA------------RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK-QADLE 1716

Query: 600  VSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEE 659
              +  ++  + LS  + L    +     +A  L+E+L+     +  + +      Q+AE+
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775

Query: 660  IESRVGS 666
            + + + +
Sbjct: 1776 LSNELAT 1782



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 85/425 (20%), Positives = 169/425 (39%), Gaps = 53/425 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ---EFAALTKELNVCR 101
            EE +R    L+   E L  ++  + +  HE +  +R L T + +   +   L  EL    
Sbjct: 1507 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1566

Query: 102  EQLLEREEEIAELKAE----------------RNNTRLLLEH-LECLVSRHERSLRMTVV 144
            +  L  E  +  LK +                R   R L E+  E    R +R+L     
Sbjct: 1567 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1626

Query: 145  KR--------QAQSPAGVSSEVEVLKALKSL----------FEHHKALDEKVRERLRVAL 186
            K+        + Q+ + +    E +K L+ L           E  +A  +++    +   
Sbjct: 1627 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1686

Query: 187  ERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQ---ENTPSTSGKRSSDGSL 243
            ++   LE +L    ++L   +    Q         D+  E+   E   S SG+ +     
Sbjct: 1687 KKAKSLEADLMQLQEDLAAAERARKQA--------DLEKEELAEELASSLSGRNALQDEK 1738

Query: 244  SHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTK 303
               E  A++ +L+E + ++      M +R+   +    +L  +L T R    K+E    +
Sbjct: 1739 RRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796

Query: 304  LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDK 363
            L+R  +E  ++  +ME  + +  K  +AA      +  L +++E E   K +  +  + K
Sbjct: 1797 LERQNKELRSKLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQK 1854

Query: 364  NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQL 423
            +++L+E L   E + +   +  E   +  A + Q    L +AEE    I    R+++ +L
Sbjct: 1855 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914

Query: 424  EEKNQ 428
            +E  +
Sbjct: 1915 DEATE 1919



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 66/311 (21%), Positives = 126/311 (40%), Gaps = 26/311 (8%)

Query: 42   SMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR 101
            S ++ R+  +  LR+ Q  +   Q +L +    RD +     TA   E  A + E +   
Sbjct: 1642 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEAD--- 1695

Query: 102  EQLLEREEEIAELKAERNNTRLLLEHL--ECLVSRHERSLRMTVVKRQAQSPAGVSSEVE 159
              L++ +E++A  +  R    L  E L  E   S   R+      +R     A +  E+E
Sbjct: 1696 --LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753

Query: 160  VLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDG 219
              +       + +A+ ++VR+  + A +  + L  E     K     ++   Q K L   
Sbjct: 1754 EEQG------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1807

Query: 220  VLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSH 279
            +    HE E    +  K S+  +L      AK+ +L+E + +++RE+    + L      
Sbjct: 1808 L----HEMEGAVKSKFK-STIAALE-----AKIAQLEEQVEQEAREKQAATKSLKQKDKK 1857

Query: 280  VTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSV 339
            + E+   ++  RK   + +E   K    V++   Q E+ EE    +       QRE    
Sbjct: 1858 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1917

Query: 340  HDLNDKLENEI 350
             + N+ +  E+
Sbjct: 1918 TESNEAMGREV 1928


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  108 bits (270), Expect = 3e-23
 Identities = 117/477 (24%), Positives = 211/477 (44%), Gaps = 55/477 (11%)

Query: 50   LLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREE 109
            LL   R+ +E  A  + +L +    +   + +L   L Q+ + LT+E N+ +EQL    E
Sbjct: 844  LLQVTRQEEEMQA-KEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETE 901

Query: 110  EIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFE 169
              AE  AE    RL  +  E     HE   R+     + +   G   + E  K  + + +
Sbjct: 902  LYAE--AEEMRVRLAAKKQELEEILHEMEARL-----EEEEDRGQQLQAERKKMAQQMLD 954

Query: 170  HHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNN----QKKTLTDGVLDIN- 224
              + L+E+   R ++ LE+ +  E ++     E++++ +QNN    ++K L + + D+  
Sbjct: 955  LEEQLEEEEAARQKLQLEKVT-AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013

Query: 225  ---HEQENTPSTSGKRSSDGSLSHE------EDLAKVIELQEIISKQSREQSQMKERLAS 275
                E+E   + +  ++   S+  E      ++     EL+++  K   + S   E++A 
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073

Query: 276  LSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQRE 335
            L + + EL+  L        K EE+   L R + + +AQK +  ++I  LE         
Sbjct: 1074 LQAQIAELKMQLAK------KEEELQAALAR-LDDEIAQKNNALKKIRELEGH------- 1119

Query: 336  ATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL 395
               + DL + L++E A ++    + E + R L E LE  + +L+ TL    T  E+ A+ 
Sbjct: 1120 ---ISDLQEDLDSERAARN----KAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172

Query: 396  AQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLL 455
             Q V  L KA      ++E  R  EAQ++E  Q+  +A +      E  KR    +DK  
Sbjct: 1173 EQEVTVLKKA------LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK-- 1224

Query: 456  SESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELD 512
              + + L+    +    L       +EVE  KK+LE    +      + E  RAEL+
Sbjct: 1225 --NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELN 1279



 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 117/528 (22%), Positives = 225/528 (42%), Gaps = 78/528 (14%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAA----LTK 95
            +    EE+    D L +T+  L   Q +L ++  + D+ QRQL + L ++       L +
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRL---QQELDDLVVDLDN-QRQLVSNLEKKQRKFDQLLAE 1459

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVS 155
            E N+  +   ER+   AE + +      L   LE  +   E  L  T    +A+    VS
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE-LERTNKMLKAEMEDLVS 1518

Query: 156  SEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATH--------------- 200
            S+ +V K +  L +  +AL+ ++ E ++  LE    LE+EL AT                
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEE-MKTQLEE---LEDELQATEDAKLRLEVNMQALKG 1574

Query: 201  ---KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE--EDLAKVIEL 255
               ++L    EQN +K+      L   HE E       K+ +  + + +  E   K +EL
Sbjct: 1575 QFERDLQARDEQNEEKRRQLQRQL---HEYETELEDERKQRALAAAAKKKLEGDLKDLEL 1631

Query: 256  QEIISKQSREQS--QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMA 313
            Q   + + RE++  Q+++  A +     ELE D   +R ++  + + N K          
Sbjct: 1632 QADSAIKGREEAIKQLRKLQAQMKDFQRELE-DARASRDEIFATAKENEK---------- 1680

Query: 314  QKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
            + + +E  +  L++   AA+R         ++L  E+A+  S     +D+ R+L+ R+  
Sbjct: 1681 KAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQ 1740

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQ-R 432
             E++L++     E + +   +  Q+   LS       +  ++      QLE +N+EL+ +
Sbjct: 1741 LEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 433  ARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA---LEDKNSLLRE------- 482
              + E   +   K     ++  +++  E+++   +E+ AA   L+ K+  L+E       
Sbjct: 1801 LHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVED 1860

Query: 483  ------------------VESAKKQLEETQHDKDQLVLNIEALRAELD 512
                              V+  K+QLEE + +  ++  N   L+ ELD
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELD 1908



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 101/527 (19%), Positives = 200/527 (37%), Gaps = 99/527 (18%)

Query: 83   NTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMT 142
            N  L +E   L + ++     L E EE+   L   +N    ++  LE  + + E+S R  
Sbjct: 994  NNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS-RQE 1052

Query: 143  VVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKE 202
            + K + +     S   E +  L++     K    K  E L+ AL R   L++E+   +  
Sbjct: 1053 LEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALAR---LDDEIAQKNNA 1109

Query: 203  LMILKE---------------------QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDG 241
            L  ++E                        QK+ L + +  +  E E+T  ++  +    
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169

Query: 242  SLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
            +   +E       L E       +  +M+++ A     +TE  E    A+ +L K+++  
Sbjct: 1170 AKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTL 1229

Query: 302  TKLQRDV-----------REAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
             K   D+           +E   +K+ +E ++  L+ +    +R    ++D   KL+NE+
Sbjct: 1230 EKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289

Query: 351  ANKDSMHRQTEDK-----------NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
             +   M  + E K           + QLQ+  EL +++ +Q L  +  L ++E E     
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ 1349

Query: 400  AALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKL----- 454
              L +  E   N+E  +  +  QL +  ++LQ      +  EE  KR    ++ L     
Sbjct: 1350 DQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 455  --------LSESNERLQLHLKERMAALEDKNSLLREVESAKKQ----------------- 489
                    L ++  RLQ  L + +  L+++  L+  +E  +++                 
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469

Query: 490  ----------------------LEETQHDKDQLVLNIEALRAELDHM 514
                                  LEE    K++L    + L+AE++ +
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 129/564 (22%), Positives = 230/564 (40%), Gaps = 84/564 (14%)

Query: 140  RMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGAT 199
            R    KRQ Q  A    +      LK        L  KV+  L+V  +     EEE+ A 
Sbjct: 803  RKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQ-----EEEMQAK 857

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
              EL   KE+  QK       L+  H Q               L+ E++L     LQE +
Sbjct: 858  EDELQKTKERQ-QKAENELKELEQKHSQ---------------LTEEKNL-----LQEQL 896

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
              ++   ++ +E    L++   ELEE L      L + E+   +LQ + ++   Q  D+E
Sbjct: 897  QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956

Query: 320  ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
            E++   E      Q E  +      KLE+EI   D  + +   + + L+ER+      L 
Sbjct: 957  EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLA 1016

Query: 380  QTLRKAETLPEV----EAELAQRVAALSKAEERHGNIEERLRQMEA-------------- 421
            +   KA+ L ++    E+ +++    L K E+    +E+  R++E               
Sbjct: 1017 EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQA 1076

Query: 422  -------QLEEKNQELQRARQR--EKMNEEHN--KRLSDTVDKLLSESNERLQLHLKERM 470
                   QL +K +ELQ A  R  +++ +++N  K++ + ++  +S+  E L      R 
Sbjct: 1077 QIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARN 1135

Query: 471  AALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGS 530
             A + K  L  E+E+ K +LE+T  D       + A R E +   L+ A     R H   
Sbjct: 1136 KAEKQKRDLGEELEALKTELEDTL-DSTATQQELRAKR-EQEVTVLKKALDEETRSHEAQ 1193

Query: 531  VPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANV 590
            V + R         + +   +  + ++ + A    + +K QTL +++ + A +  VL   
Sbjct: 1194 VQEMR------QKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQA 1246

Query: 591  ------------AQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQE---Q 635
                        AQ  E  +  SDGE  R  L   V  L    Q +  ++  ML E   +
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL----QNEVESVTGMLNEAEGK 1302

Query: 636  LDAINKEIRLIQEEKENTEQRAEE 659
               + K++  +  + ++T++  +E
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQE 1326



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 82/667 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR--- 101
            EE + L   L +T ++ A  Q    E+  +R+     L  AL +E  +   ++   R   
Sbjct: 1146 EELEALKTELEDTLDSTATQQ----ELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKH 1201

Query: 102  ----EQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSE 157
                E+L E+ E+    KA  +  +  LE     ++   R L     + + +    + ++
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK-LEAQ 1260

Query: 158  VEVLKALKSLFEHHKA-LDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTL 216
            V+ L++  S  E  +A L++KV +          +L E  G   K    +   ++Q +  
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD- 1319

Query: 217  TDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE----LQEIISKQSREQSQMKER 272
            T  +L     Q+   ST  ++  +   S ++ L + +E    L+  IS  + + S  K++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKK 1379

Query: 273  LASLSSHVTELEEDLDTARKDLI--------------KSEEMNTKLQRDVREAMAQKEDM 318
            L   +S V  LEE     +K++               K E+   +LQ+++ + +   ++ 
Sbjct: 1380 LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439

Query: 319  EERITTLEKRY------LAAQREATSVH-DLNDKLENEIANKDSMHRQTEDKNRQLQERL 371
             + ++ LEK+       LA ++  +S + D  D+ E E   K++   +     R L+E L
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKET---KALSLARALEEAL 1496

Query: 372  ELAEQKLQQTLR----KAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKN 427
            E A+++L++T +    + E L   + ++ + V  L K++     +E ++ +M+ QLEE  
Sbjct: 1497 E-AKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA---LETQMEEMKTQLEELE 1552

Query: 428  QELQRARQREKMNEEHN--------KRLSDTVDKLLSESNERLQLHLKERMAALEDKNSL 479
             ELQ A +  K+  E N        +R     D+   E   +LQ  L E    LED+   
Sbjct: 1553 DELQ-ATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQ 1611

Query: 480  LREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMA 539
                 +AKK+LE    D     L ++A  A    ++ R  ++   R     + DF+  + 
Sbjct: 1612 RALAAAAKKKLEGDLKD-----LELQADSA----IKGREEAIKQLRKLQAQMKDFQRELE 1662

Query: 540  DGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDAD 599
            D             R  +  + A   E  K     E D  + Q+    A  A+  ++D +
Sbjct: 1663 DA------------RASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK-QADLE 1709

Query: 600  VSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEE 659
              +  ++  + LS  + L    +     +A  L+E+L+     +  + +      Q+AE+
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIA-QLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768

Query: 660  IESRVGS 666
            + + + +
Sbjct: 1769 LSNELAT 1775



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 85/425 (20%), Positives = 169/425 (39%), Gaps = 53/425 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ---EFAALTKELNVCR 101
            EE +R    L+   E L  ++  + +  HE +  +R L T + +   +   L  EL    
Sbjct: 1500 EELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATE 1559

Query: 102  EQLLEREEEIAELKAE----------------RNNTRLLLEH-LECLVSRHERSLRMTVV 144
            +  L  E  +  LK +                R   R L E+  E    R +R+L     
Sbjct: 1560 DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAK 1619

Query: 145  KR--------QAQSPAGVSSEVEVLKALKSL----------FEHHKALDEKVRERLRVAL 186
            K+        + Q+ + +    E +K L+ L           E  +A  +++    +   
Sbjct: 1620 KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENE 1679

Query: 187  ERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQ---ENTPSTSGKRSSDGSL 243
            ++   LE +L    ++L   +    Q         D+  E+   E   S SG+ +     
Sbjct: 1680 KKAKSLEADLMQLQEDLAAAERARKQA--------DLEKEELAEELASSLSGRNALQDEK 1731

Query: 244  SHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTK 303
               E  A++ +L+E + ++      M +R+   +    +L  +L T R    K+E    +
Sbjct: 1732 RRLE--ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789

Query: 304  LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDK 363
            L+R  +E  ++  +ME  + +  K  +AA      +  L +++E E   K +  +  + K
Sbjct: 1790 LERQNKELRSKLHEMEGAVKSKFKSTIAALE--AKIAQLEEQVEQEAREKQAATKSLKQK 1847

Query: 364  NRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQL 423
            +++L+E L   E + +   +  E   +  A + Q    L +AEE    I    R+++ +L
Sbjct: 1848 DKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907

Query: 424  EEKNQ 428
            +E  +
Sbjct: 1908 DEATE 1912



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 66/311 (21%), Positives = 126/311 (40%), Gaps = 26/311 (8%)

Query: 42   SMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCR 101
            S ++ R+  +  LR+ Q  +   Q +L +    RD +     TA   E  A + E +   
Sbjct: 1635 SAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENEKKAKSLEAD--- 1688

Query: 102  EQLLEREEEIAELKAERNNTRLLLEHL--ECLVSRHERSLRMTVVKRQAQSPAGVSSEVE 159
              L++ +E++A  +  R    L  E L  E   S   R+      +R     A +  E+E
Sbjct: 1689 --LMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746

Query: 160  VLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDG 219
              +       + +A+ ++VR+  + A +  + L  E     K     ++   Q K L   
Sbjct: 1747 EEQG------NMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSK 1800

Query: 220  VLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSH 279
            +    HE E    +  K S+  +L      AK+ +L+E + +++RE+    + L      
Sbjct: 1801 L----HEMEGAVKSKFK-STIAALE-----AKIAQLEEQVEQEAREKQAATKSLKQKDKK 1850

Query: 280  VTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSV 339
            + E+   ++  RK   + +E   K    V++   Q E+ EE    +       QRE    
Sbjct: 1851 LKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEA 1910

Query: 340  HDLNDKLENEI 350
             + N+ +  E+
Sbjct: 1911 TESNEAMGREV 1921


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  105 bits (263), Expect = 2e-22
 Identities = 197/933 (21%), Positives = 376/933 (40%), Gaps = 97/933 (10%)

Query: 44   LEERDRLLD-TLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ---EFAALTKELNV 99
            LE+  R LD    + Q+ +A  Q ++ E+  +    + +L  AL +   E       L V
Sbjct: 1053 LEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112

Query: 100  CRE---QLLEREEEIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQSPA 152
             RE   Q+ E +E+    KA RN      R L E LE L +  E +L  T  +++ ++  
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172

Query: 153  GVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQ 212
                  E+ KAL+   ++H+A  + +R+R   ALE  S   E+     K      E+N Q
Sbjct: 1173 E-QEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQA----KRFKANLEKNKQ 1227

Query: 213  KKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKER 272
                  G+   N E         +  ++     ++  A+V EL   +S+  R + ++ E+
Sbjct: 1228 ------GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1281

Query: 273  LASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAA 332
                    ++L+ +LD     L ++E+   K  +D     +Q +D +E +    ++ L  
Sbjct: 1282 -------ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334

Query: 333  QREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVE 392
                  + +  + L+ +   ++   +  E +   LQ +L   ++K+   L   E+L E +
Sbjct: 1335 SSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK 1394

Query: 393  AELAQRVAALSKAEER----HGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLS 448
             +L +   ALS+  E     +  +E+   +++ +L++   +L   RQ     E+  K+  
Sbjct: 1395 KKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF- 1453

Query: 449  DTVDKLLSESNERLQLHLKERMAALEDKN-------SLLREVESAKKQLEETQHDKDQLV 501
               D+LL+E       + +ER  A  +         SL R +E A +  EE +    QL 
Sbjct: 1454 ---DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510

Query: 502  LNIEALRAELDHMRLRGASLHHGRPHL-GSVPDFRFPMADGHTDSYSTSAVLRRPQKGRL 560
             ++E L +  D +      L   +  L   V + R  + +   +  +T     R +    
Sbjct: 1511 ADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 561  AALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSS-----VD 615
            A        +QT +EQ+ E+ +       + Q  E +A++ D    R   ++S     +D
Sbjct: 1571 AMKAQFERDLQTRDEQNEEKKRLL-----IKQVRELEAELEDERKQRALAVASKKKMEID 1625

Query: 616  LLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIES---RVGSGSLDNL 672
            L     Q +A   A       D + K++R +Q + ++ ++  EE  +    + + S ++ 
Sbjct: 1626 LKDLEAQIEAANKAR------DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE 1679

Query: 673  GRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDD 732
             + +S+ +        LASS          R   H+     +    +T     +  + D+
Sbjct: 1680 KKLKSLEAEILQLQEELASSE---------RARRHAEQERDELADEITNSASGKSALLDE 1730

Query: 733  KTTIKC-------ETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPS 785
            K  ++        E     S   L  DR  K  L         D  N+  + +   S   
Sbjct: 1731 KRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQV-------DTLNAELAAER--SAAQ 1781

Query: 786  SSNSSQDSLHKAPKKKGIKSSIGRLFGK-KEKGRPGQTGKEA-LGQAGVSETDNSSQDAL 843
             S++++  L +  + K +K+ +  L G  K K +   +  EA +GQ    + +  +++  
Sbjct: 1782 KSDNARQQLER--QNKELKAKLQELEGAVKSKFKATISALEAKIGQL-EEQLEQEAKERA 1838

Query: 844  GLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRA 903
              +KL  + EK  KL++    +E+ RR    + +          +L   +      A RA
Sbjct: 1839 AANKLVRRTEK--KLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896

Query: 904  NVKSGAIMSALSDTEIQREIGISNPLHRLKLRL 936
            N     +   L D     E G+S  +  LK RL
Sbjct: 1897 NASRRKLQRELDDATEANE-GLSREVSTLKNRL 1928



 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 133/653 (20%), Positives = 280/653 (42%), Gaps = 65/653 (9%)

Query: 40   MVSMLEERDRLLDTLRETQETLAL----TQGKLHEVGHERDSLQRQLNTALPQEFAALTK 95
            M + +++ +  LD     ++ L L     + K+ ++  E   L+ Q N+   +E   +  
Sbjct: 948  MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ-NSKFIKEKKLMED 1006

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVS 155
             +  C  QL E EE+   L   RN   +++  LE  + + E++ R  + K + +     +
Sbjct: 1007 RIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKT-RQELEKAKRKLDGETT 1065

Query: 156  SEVEVLKALKSLFEHHKALDEKVRERLRVALER--------------CSLLEEELGATHK 201
               + +  L++  +  K    K  E L+ AL R                 L+ ++    +
Sbjct: 1066 DLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQE 1125

Query: 202  ELMILKEQNN----QKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQE 257
            +    K   N    QK+ L++ +  +  E E+T  T+  +    +   +E    V EL++
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE----VAELKK 1181

Query: 258  IISKQSR-EQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKE 316
             + ++++  ++Q+++     ++ + EL E L+ A++     E+    L+ D +E   + +
Sbjct: 1182 ALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVK 1241

Query: 317  DMEERITTLEKRYLAAQREATSVH---DLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
             +++     E +      +   +H      D+L  E+A K S  +   D    L   LE 
Sbjct: 1242 VLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL---LEE 1298

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRA 433
            AE+K    ++ A+    +E++L      L +   +  N+  R+RQ+E   EEKN  LQ  
Sbjct: 1299 AEKK---GIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE---EEKN-SLQEQ 1351

Query: 434  RQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEET 493
            ++ E+   ++ ++    +   L+++ +++   L    +  E K  LL++ E+  ++LEE 
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411

Query: 494  QHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLR 553
                D+L      L+ ELD + +    L H R    ++   +        +  S SA   
Sbjct: 1412 ALAYDKLEKTKNRLQQELDDLTV---DLDHQRQVASNLEKKQKKFDQLLAEEKSISARYA 1468

Query: 554  RPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESD-----ADVSDGEDDRD 608
              +    A  R++ +K  +L      RA + ++ A   + FE       AD+ D    +D
Sbjct: 1469 EERDRAEAEAREKETKALSL-----ARALEEALEAK--EEFERQNKQLRADMEDLMSSKD 1521

Query: 609  TLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIE 661
             +  +V  L  S +A        L++Q++ +  ++  +++E + TE     +E
Sbjct: 1522 DVGKNVHELEKSKRA--------LEQQVEEMRTQLEELEDELQATEDAKLRLE 1566



 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 124/553 (22%), Positives = 230/553 (41%), Gaps = 104/553 (18%)

Query: 177  KVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGK 236
            KV+  L+V  +     EEEL A  +EL+ +KE    K+T  +G L+   E E        
Sbjct: 840  KVKPLLQVTRQ-----EEELQAKDEELLKVKE----KQTKVEGELE---EMER------- 880

Query: 237  RSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIK 296
                    H++ L +   L E +  ++   ++ +E  A L++   ELEE L      + +
Sbjct: 881  -------KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE 933

Query: 297  SEEMNTKLQRDVREAMAQKEDMEERI--------------TTLEKRYLAAQREATSVHDL 342
             EE N  LQ + ++  A  +D+EE++               T E +    + E   + D 
Sbjct: 934  EEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ 993

Query: 343  NDK-------LENEIANKDSMHRQTEDKNRQL---QERLELAEQKLQQTLRKAE-TLPEV 391
            N K       +E+ IA   S   + E+K + L   + + E+    L++ L+K E T  E+
Sbjct: 994  NSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQEL 1053

Query: 392  EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR---EKMNEEHNKRLS 448
            E    +     +  +++   ++ ++ +++ QL +K +ELQ A  R   E +++ +  ++ 
Sbjct: 1054 EKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVV 1113

Query: 449  DTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALR 508
              +   ++E  E  +     R  A + K  L  E+E+ K +LE+T        L+  A +
Sbjct: 1114 RELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDT--------LDTTAAQ 1165

Query: 509  AELDHMR------LRGASLHHGRPHLGSVPDFR-------FPMADGHTDSYSTSAVLRRP 555
             EL   R      L+ A     + H   + D R         +++    +    A L + 
Sbjct: 1166 QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKN 1225

Query: 556  QKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGE----------- 604
            ++G     ++   +V+ L +   E   +   L   AQ  E  A VS+G+           
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLD--AQVQELHAKVSEGDRLRVELAEKAS 1283

Query: 605  ------DDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKE----------IRLIQE 648
                  D+  TLL   +        DA +L   LQ+  + + +E          IR ++E
Sbjct: 1284 KLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEE 1343

Query: 649  EKENTEQRAEEIE 661
            EK + +++ EE E
Sbjct: 1344 EKNSLQEQQEEEE 1356



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 125/654 (19%), Positives = 270/654 (41%), Gaps = 114/654 (17%)

Query: 99   VCREQLLEREEEIAELKAERNNTR--LLLEHLEC--LVSRHERSLRMTVVKRQAQSPAGV 154
            + R+   +++++++ LK  + N    L L H +   + ++ +  L++T  + + Q+    
Sbjct: 801  LARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQA---- 856

Query: 155  SSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKK 214
              + E+LK  +   +    L+E  R+  ++ LE  ++L E+L A  +     +E   +  
Sbjct: 857  -KDEELLKVKEKQTKVEGELEEMERKHQQL-LEEKNILAEQLQAETELFAEAEEMRARLA 914

Query: 215  TLTDGVLDINHEQENTPSTSGKRSS----------------DGSLSHEEDLAKVIELQEI 258
                 + +I H+ E+      +R+                 +  L  EE   + ++L+++
Sbjct: 915  AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV 974

Query: 259  I-------------------SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEE 299
                                SK  +E+  M++R+A  SS + E EE      K   K E 
Sbjct: 975  TAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEV 1034

Query: 300  MNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQ 359
            M + L+  +++    ++++E+      KR L  +       DL D++    A  D +  Q
Sbjct: 1035 MISDLEERLKKEEKTRQELEK-----AKRKLDGE-----TTDLQDQIAELQAQIDELKLQ 1084

Query: 360  TEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQ-------RVAALSKAEERHGNI 412
               K  +LQ  L   + +        + + E++A++A+         A+ +KAE++  ++
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144

Query: 413  EERLRQMEAQLEE------KNQELQRARQRE--------------------KMNEEHNKR 446
             E L  ++ +LE+        QEL+  R++E                     M + H   
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204

Query: 447  LSDTVDKLLSESNERLQLHLKERMAALE-DKNSLLREVESAKKQLEETQHDKDQLVLNIE 505
            L +  ++L  E  +R + +L++    LE D   L  EV+  ++   E++H + +L   ++
Sbjct: 1205 LEELSEQL--EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQ 1262

Query: 506  ALRAEL---DHMRL----RGASLHHGRPHLGSVPD--------FRFPMADGHTDSYSTSA 550
             L A++   D +R+    + + L +   ++ ++ +        F    A   +    T  
Sbjct: 1263 ELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQE 1322

Query: 551  VLRRPQKGRL---AALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESD-ADVSDGEDD 606
            +L+   + +L   + +R    +  +L EQ  E  +    L     A +S  AD     DD
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382

Query: 607  RDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
                + S++        DA  L+  L+E+  A +K    +++ K   +Q  +++
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK----LEKTKNRLQQELDDL 1432


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1723 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1772

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1833 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1891 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2120

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2239

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2240 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 657  AEEIE 661
            AEE +
Sbjct: 2358 AEETQ 2362



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1952 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 2008

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 2009 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2127 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2360

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2361 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2468

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2588 AEENQRLREQLQLLEEQ 2604



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2183 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2294

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2411

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2412 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2647

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2648 GLRRKVSAQRLQEAGI 2663



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1292

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1353 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1574 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1624

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1625 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1676

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1677 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1734 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1793 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1438

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1496

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1497 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1552 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1851 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1887

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1888 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1942

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 2000 AARQRKAALEEVERLKA 2016



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1137

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1370

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1491 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1599

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1829

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1830 EAERVLAEKLAAIGEATR 1847



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 378 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 437

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 438 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 491

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 550

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 551 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 608

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 609 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 668

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 669 EKKIKELQNAGDRLL 683


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1727 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1776

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1777 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1836

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1837 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1894

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1895 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1950

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1951 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2010

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 2011 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2124

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2243

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2244 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2301

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2302 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361

Query: 657  AEEIE 661
            AEE +
Sbjct: 2362 AEETQ 2366



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1956 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 2012

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 2013 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2070

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2071 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2130

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2131 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2187 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2246

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2247 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2364

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2365 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2413

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2414 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2472

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2473 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2532

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2533 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2592 AEENQRLREQLQLLEEQ 2608



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2187 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2245

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2246 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2298

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2299 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2358

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2359 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2415

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2416 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2471

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2472 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2531

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2532 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2591

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2592 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2651

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2652 GLRRKVSAQRLQEAGI 2667



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1296

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1357 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1403

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1457

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1458 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1518 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1577

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1578 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1628

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1629 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1680

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1681 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1738 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1797 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1853

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1854 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1913

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1914 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1973

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1974 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2007



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1442

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1443 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1500

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1501 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1556 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1614

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1615 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1674

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1675 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1734

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1735 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1794

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1795 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1855 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1891

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1892 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1946

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1947 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 2004 AARQRKAALEEVERLKA 2020



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1023 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1082

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1083 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1141

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1142 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1201

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1262 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1321

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1322 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1374

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1434

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1435 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1494

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1495 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1548

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1549 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1603

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1604 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1663

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1724 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1833

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1834 EAERVLAEKLAAIGEATR 1851



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 382 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 441

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 442 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 495

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 496 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 554

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 555 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 612

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 613 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 672

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 673 EKKIKELQNAGDRLL 687


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1723 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1772

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1773 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1832

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1833 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1890

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1891 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1946

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1947 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2006

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 2007 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2120

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2239

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2240 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2297

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2298 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357

Query: 657  AEEIE 661
            AEE +
Sbjct: 2358 AEETQ 2362



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1952 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 2008

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 2009 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2066

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2067 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2126

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2127 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2183 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2242

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2243 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2360

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2361 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2409

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2410 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2468

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2469 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2528

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2529 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2588 AEENQRLREQLQLLEEQ 2604



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2183 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2241

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2242 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2294

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2295 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2354

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2355 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2411

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2412 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2467

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2468 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2527

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2528 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2587

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2588 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2647

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2648 GLRRKVSAQRLQEAGI 2663



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1292

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1353 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1399

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1453

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1454 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1514 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1573

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1574 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1624

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1625 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1676

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1677 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1734 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1793 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1849

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1850 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1909

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1910 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1969

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1970 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2003



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1438

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1439 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1496

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1497 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1552 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1610

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1611 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1670

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1671 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1730

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1731 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1790

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1851 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1887

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1888 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1942

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1943 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 2000 AARQRKAALEEVERLKA 2016



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1019 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1078

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1079 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1137

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1138 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1197

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1258 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1317

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1318 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1370

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1430

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1431 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1490

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1491 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1544

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1545 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1599

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1600 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1659

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1720 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1829

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1830 EAERVLAEKLAAIGEATR 1847



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 378 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 437

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 438 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 491

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 492 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 550

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 551 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 608

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 609 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 668

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 669 EKKIKELQNAGDRLL 683


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1691 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1740

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1741 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1800

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1801 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1858

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1859 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1914

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1915 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1974

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 1975 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2088

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2089 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2148

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2207

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2208 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2265

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2266 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325

Query: 657  AEEIE 661
            AEE +
Sbjct: 2326 AEETQ 2330



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1920 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 1976

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 1977 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2034

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2035 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2094

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2095 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2151 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2210

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2211 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2328

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2329 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2377

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2378 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2436

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2437 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2496

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2497 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2556 AEENQRLREQLQLLEEQ 2572



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2151 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2209

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2210 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2262

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2263 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2322

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2323 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2379

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2380 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2435

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2436 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2495

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2496 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2555

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2556 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2615

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2616 GLRRKVSAQRLQEAGI 2631



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1260

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1321 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1367

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1421

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1422 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1482 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1541

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1542 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1592

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1593 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1644

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1645 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1702 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1761 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1817

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1818 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1877

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1878 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1937

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1938 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1971



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1406

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1407 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1464

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1465 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1520 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1578

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1579 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1638

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1639 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1698

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1699 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1758

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1759 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1819 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1855

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1856 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1910

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1911 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 1968 AARQRKAALEEVERLKA 1984



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 987  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1046

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1047 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1105

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1106 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1165

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1226 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1285

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1286 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1338

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1398

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1399 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1458

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1459 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1512

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1513 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1567

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1568 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1627

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1688 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1797

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1798 EAERVLAEKLAAIGEATR 1815



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 346 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 405

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 406 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 459

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 460 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 518

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 519 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 576

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 577 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 636

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 637 EKKIKELQNAGDRLL 651


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1860 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1909

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1910 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1969

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1970 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 2027

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 2028 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2257

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2258 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2317

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2376

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2377 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2434

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2435 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494

Query: 657  AEEIE 661
            AEE +
Sbjct: 2495 AEETQ 2499



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 2089 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 2145

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 2146 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2204 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2264 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2320 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2379

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2380 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2497

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2498 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2546

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2605

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2606 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2665

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2666 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2725 AEENQRLREQLQLLEEQ 2741



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2320 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2378

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2379 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2431

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2491

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2492 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2548

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2549 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2604

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2605 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2665 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2724

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2725 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2784

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2785 GLRRKVSAQRLQEAGI 2800



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1429

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1490 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1536

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1590

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1651 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1710

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1711 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1761

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1762 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1813

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1814 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1871 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1930 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1986

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1987 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 2046

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2140



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1575

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1633

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1634 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1689 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1928 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1988 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 2024

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 2025 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 2079

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 2080 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 2137 AARQRKAALEEVERLKA 2153



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1274

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1275 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1334

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1507

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1567

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1628 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1681

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1682 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1736

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1737 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1966

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1967 EAERVLAEKLAAIGEATR 1984



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 515 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 574

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 575 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 628

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 629 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 687

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 688 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 745

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 746 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 805

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 806 EKKIKELQNAGDRLL 820


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1701 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1750

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1751 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1810

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1811 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1868

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1869 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 1985 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2098

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2099 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2158

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2217

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2218 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2275

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2276 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335

Query: 657  AEEIE 661
            AEE +
Sbjct: 2336 AEETQ 2340



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1930 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 1986

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 1987 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2044

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2045 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2105 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2338

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2339 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2387

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2446

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2447 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2506

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2507 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2566 AEENQRLREQLQLLEEQ 2582



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2161 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2219

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2220 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2272

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2332

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2333 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2389

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2390 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2445

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2446 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2506 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2565

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2566 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2625

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2626 GLRRKVSAQRLQEAGI 2641



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1270

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1331 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1377

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1431

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1492 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1551

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1552 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1602

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1603 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1654

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1655 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1712 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1771 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1827

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1828 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1887

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1981



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1416

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1474

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1475 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1530 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1769 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1829 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1865

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1866 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1920

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 1978 AARQRKAALEEVERLKA 1994



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1115

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1116 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1175

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1348

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1408

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1469 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1522

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1523 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1577

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1578 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1698 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1807

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1808 EAERVLAEKLAAIGEATR 1825



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 356 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 415

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 416 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 469

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 470 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 528

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 529 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 586

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 587 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 646

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 647 EKKIKELQNAGDRLL 661


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1709 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1758

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1759 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1818

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1819 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1876

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1877 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1932

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1933 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1992

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 1993 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2106

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2107 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2166

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2225

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2226 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2283

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2284 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343

Query: 657  AEEIE 661
            AEE +
Sbjct: 2344 AEETQ 2348



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1938 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 1994

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 1995 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2052

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2053 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2112

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2113 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2169 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2228

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2229 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2346

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2347 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2395

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2396 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2454

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2455 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2514

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2515 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2574 AEENQRLREQLQLLEEQ 2590



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2169 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2227

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2228 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2280

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2281 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2340

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2341 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2397

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2398 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2453

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2454 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2513

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2514 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2573

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2574 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2633

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2634 GLRRKVSAQRLQEAGI 2649



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1278

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1339 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1385

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1439

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1440 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1500 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1559

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1560 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1610

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1611 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1662

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1663 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1720 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1779 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1835

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1836 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1895

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1896 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1955

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1956 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 1989



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1424

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1425 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1482

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1483 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1538 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1596

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1597 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1656

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1657 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1716

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1717 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1776

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1837 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1873

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1874 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1928

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1929 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 1986 AARQRKAALEEVERLKA 2002



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1005 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1064

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1065 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1123

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1124 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1183

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1244 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1303

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1304 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1356

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1357 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1416

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1417 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1476

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1477 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1530

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1531 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1585

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1586 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1645

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1706 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1815

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1816 EAERVLAEKLAAIGEATR 1833



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 364 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 423

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 424 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 477

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 478 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 536

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 537 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 594

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 595 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 654

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 655 EKKIKELQNAGDRLL 669


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 159/665 (23%), Positives = 278/665 (41%), Gaps = 102/665 (15%)

Query: 74   ERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVS 133
            E+   QRQL   L +E A L +E     ++  E E E+A+++AE       +E L    +
Sbjct: 1750 EQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAE-------MEVLLASKA 1799

Query: 134  RHERSLRMTVVK--RQAQSPAG----VSSEVEVLKALKSLFEHHKALDEKVRERLRVALE 187
            R E   R T  K  ++ ++ AG    ++ E   L+AL    +  + L E+   R R   E
Sbjct: 1800 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE 1859

Query: 188  RCSLLEEELGATHKELMI-------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSD 240
            R  +L E+L A  +   +       LKE+  + + L     D   ++      + +  +D
Sbjct: 1860 R--VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD 1917

Query: 241  GSLSHEEDLAKV-------IELQE-IISKQSREQSQMKERLASLSSHV-------TELEE 285
                 EE LA++       +E Q+ ++    R++ Q++E + +L +          ELE 
Sbjct: 1918 ----IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1973

Query: 286  DLDTAR---KDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREAT----- 337
            +L   R   +D ++S+E         R+  A++E          ++ LAA+ EA      
Sbjct: 1974 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2033

Query: 338  -------------SVHDLNDKLENEIANKDSMHRQTEDKNRQLQER-----LELAEQKLQ 379
                             L ++ E E A +  + ++   K  Q +E+     ++  EQ+LQ
Sbjct: 2034 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093

Query: 380  QTLRKAETLPEV---EAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR 436
            QTL++ +++ +    EAE A+R A   +AEE     E    Q   Q+EE     +R +Q 
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAA--EEAEEARVQAEREAAQSRRQVEEA----ERLKQS 2147

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHD 496
             +   +   +     +KL  E+ +      +   AAL  K +   E+E  KK  E+T   
Sbjct: 2148 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2207

Query: 497  KDQLVLNIEALRAEL---DH---------MRLRGASLHHGRPHLGSVPDFRFPMADGHTD 544
            K Q+   +  LR +L   DH          RL+  +    R     V +  F +     +
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR-SQVEEELFSVRVQMEE 2266

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSD-- 602
                 A  R   + R   LRD+ +  + L E+  +  Q A   A ++ A +  A +    
Sbjct: 2267 LSKLKA--RIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA 2324

Query: 603  GEDDRDTLLSSVDLLSPSGQA--DAHTL---AMMLQEQLDAINKEIRLIQEEKEN-TEQR 656
             ED       +  +L    QA  +A  L   A +LQ+Q +   ++ R +QE+KE   +Q 
Sbjct: 2325 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384

Query: 657  AEEIE 661
            AEE +
Sbjct: 2385 AEETQ 2389



 Score = 74.3 bits (181), Expect = 6e-13
 Identities = 132/677 (19%), Positives = 268/677 (39%), Gaps = 84/677 (12%)

Query: 47   RDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLE 106
            R    DTLR ++E   L   +  ++  E +  +R+    + +  AA  +     +  L  
Sbjct: 1979 RSNAEDTLR-SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL-- 2035

Query: 107  REEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR-QAQSPAGVSSEVEVLKALK 165
              EE+  LKA+    R L E  E   +R  +  +    KR QA+  A   +  +  + L+
Sbjct: 2036 --EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2093

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
               +  +++ +++R     A       EE      +E    + Q  + + L     +   
Sbjct: 2094 QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2153

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR----EQSQMKERLASLSSHVT 281
             +    + + K   +     E++ A+  + ++   +Q +    E  + K+          
Sbjct: 2154 ARAQAQAAAEKLRKEA----EQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209

Query: 282  ELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHD 341
            ++E++L T R  L +++     L  +++   A+  +   + + +E+   + + +   +  
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269

Query: 342  LNDKLENE-----IANKDSMHR---QTEDKNRQLQERL--------------ELAEQKLQ 379
            L  ++E E     + +KD+  R   +  +K +Q+ E                +LAE+ L 
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329

Query: 380  QTLRKAE-------------TLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEK 426
            Q    AE             T  + EAEL Q+   L  A+E+   ++E   QM  QL E+
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKEL--AQEQARRLQEDKEQMAQQLAEE 2387

Query: 427  NQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKE----RMAALEDKNSLLRE 482
             Q  QR  + E+  +             +S   ERL+L + E    +  A ED     ++
Sbjct: 2388 TQGFQRTLEAERQRQLE-----------MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQ 2436

Query: 483  VESAKKQLEETQ---HDKDQLVLNIEALRAELDH----MRLRGASLHHGRPHLGSVPDFR 535
             E   ++L  T+    +K  LV  +E  R + DH    +R   A L   +  L       
Sbjct: 2437 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKL- 2495

Query: 536  FPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLAN-VAQA- 593
              +      +     +L+  Q  + + L ++ S +Q     + E+A+   +  + VA+A 
Sbjct: 2496 LQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQ 2555

Query: 594  ---FESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIR----LI 646
                E        E +R  L++S++  +   Q +A       QE+L  + ++ R    L+
Sbjct: 2556 QLREEQQRQQQQMEQERQRLVASME-EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614

Query: 647  QEEKENTEQRAEEIESR 663
             EE +   ++ + +E +
Sbjct: 2615 AEENQRLREQLQLLEEQ 2631



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 110/496 (22%), Positives = 210/496 (42%), Gaps = 59/496 (11%)

Query: 70   EVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLE 129
            +V  E  +L+ QL     Q+   L +EL   + +  E   + ++++ E  + R+ +E L 
Sbjct: 2210 QVEQELTTLRLQLEETDHQK-NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELS 2268

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERC 189
             L +R E   R  +++ +  +   +  E E    +K + E    L    +E  R+     
Sbjct: 2269 KLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVAAQEAARLR---- 2321

Query: 190  SLLEEELG---ATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE 246
             L EE+L    A  ++++  K Q  Q+ T      ++  +Q+       +R  +      
Sbjct: 2322 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMA 2381

Query: 247  EDLAKVIE-LQEIISKQSREQSQM-------KERLASLSSHVTELEEDLDTARKDLIKSE 298
            + LA+  +  Q  +  + + Q +M       K R+A +S      EED    RK   ++E
Sbjct: 2382 QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRK---QAE 2438

Query: 299  EMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHR 358
            E+  KL R     +A +E +   + TLE +   +  +A  + +   +LE E        +
Sbjct: 2439 EIGEKLHRT---ELATQEKVT-LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAK 2494

Query: 359  QTEDKNRQLQ----ERLELAEQKLQQT-LRKAETLPEVEAELAQRVAAL--------SKA 405
              + K+ ++Q    E+L    Q LQQ+ L + ++L + E  + Q  A L        +KA
Sbjct: 2495 LLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2554

Query: 406  EERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTV----------DKLL 455
            ++     + + +QME + +     ++ AR+R+   EE  +R  + +          ++LL
Sbjct: 2555 QQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELL 2614

Query: 456  SESNER----LQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIE------ 505
            +E N+R    LQL  ++  AAL     +     +A K L   +   D      E      
Sbjct: 2615 AEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFD 2674

Query: 506  ALRAELDHMRLRGASL 521
             LR ++   RL+ A +
Sbjct: 2675 GLRRKVSAQRLQEAGI 2690



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 167/874 (19%), Positives = 310/874 (35%), Gaps = 97/874 (11%)

Query: 47   RDRLLDTLRETQETLALT---QGKLHEVGHE---------------RDSLQRQLNT-ALP 87
            R+R+   L   Q  LA T   Q +L ++G +               +D+ +RQ    A+P
Sbjct: 1205 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1264

Query: 88   QEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQ 147
               +   +E     + LLE  E   E   E    R   +++  +    +  L++   K Q
Sbjct: 1265 LADSQAVREQLRQEQALLEEIERHGEKVEECQ--RFAKQYINAI---KDYELQLVTYKAQ 1319

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILK 207
             +  A  + + +V    +S+ + +  L     E   +  +    + E L    +E  + +
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379

Query: 208  EQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +Q  +             E+E              L+     AK    +E    Q R Q 
Sbjct: 1380 QQRAE-------------ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE 1426

Query: 268  QM---KERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKED---MEER 321
            ++   +E           ++E+L   R      +    ++Q   R+A A +     +EE 
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLR------QSSEAEIQAKARQAEAAERSRLRIEEE 1480

Query: 322  ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
            I  +  +  A +R+          L       ++  RQ +++  +L+ +++   Q+ +Q 
Sbjct: 1481 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540

Query: 382  LRKAETLPEVEAELA-QRVAALSKAEERHGNIEE---RLRQMEAQLEEKNQELQRARQRE 437
              +  +  + EAE A ++  AL   EE     EE   RLRQ E +   + Q      QR 
Sbjct: 1541 EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRS 1600

Query: 438  KMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDK 497
               E  +KR S       +E   +L+  L+E   A+     L  E E   +Q  E +  +
Sbjct: 1601 AEAELQSKRAS------FAEKTAQLERSLQEEHVAVAQ---LREEAERRAQQQAEAERAR 1651

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQK 557
            ++          EL+  +L+       R     V   +  +A    +     A     ++
Sbjct: 1652 EEA-------ERELERWQLKANEALRLRLQAEEVAQQK-SLAQAEAEKQKEEAEREARRR 1703

Query: 558  GRLAALRDEPSKVQTLNEQDWERAQQASV------LANVAQAFESDADVSDGEDDRDTLL 611
            G+     ++  + + L EQ+ E+ +Q +       LA   +     A+   GE  R  L 
Sbjct: 1704 GKA---EEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760

Query: 612  SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDN 671
              +  L     A A      L+ +L  +  E+ ++   K   E+ +     +        
Sbjct: 1761 EELARLQREAAA-ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDR--------LGVMTLLP 723
             GRFR ++      A   A +      R            E +R        +G  T L 
Sbjct: 1820 AGRFRELAE---EAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLK 1876

Query: 724  PSREEVRDDKTTIKCETSPPSSPRALRLDRLHK-GALHTVSHED-IRDIRNSTGS----Q 777
               E    +K          +   A +  RL +  A H    E+ +  +R ++ S    Q
Sbjct: 1877 TEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ 1936

Query: 778  DGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDN 837
             G V +        +    A K    K++ G+   + E GR     ++ L     +E + 
Sbjct: 1937 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1996

Query: 838  SSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQ 871
            + Q  L   +   + E   ++QK     EEA RQ
Sbjct: 1997 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ 2030



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 138/677 (20%), Positives = 264/677 (38%), Gaps = 69/677 (10%)

Query: 28   SQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALP 87
            ++  A+   ++L   M EE  R  +   + Q+     Q +L ++   R S + ++     
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL---RQSSEAEIQAKAR 1465

Query: 88   QEFAA------LTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRM 141
            Q  AA      + +E+ V R QL   E +    + E    R   E  E    + +     
Sbjct: 1466 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEA--QKRQAQEEA 1523

Query: 142  TVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRV--ALERCSLLEEELGAT 199
              ++RQ Q  +    + EV      L    KA  E  RE+ R   ALE   L  EE    
Sbjct: 1524 ERLRRQVQDESQRKRQAEV-----ELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEII 259
             ++  + + +  Q   L         E ++  ++  ++++    S +E+   V +L+E  
Sbjct: 1579 LRQAEVERARQVQV-ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1637

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDME 319
             +++++Q++ +         +   +   + A +  +++EE+  +      EA  QKE+ E
Sbjct: 1638 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1697

Query: 320  E-------------RITTLEKRYLAAQRE-ATSVHDLNDKLENEIANKDSMHRQTEDKNR 365
                          R   L ++ L  QR+ A          E E+    +   Q E + +
Sbjct: 1698 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1757

Query: 366  QLQERLELAEQKLQQTLRKAETLP----EVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
             L+E L   +++     +K + L     +V AE+   +A+ ++AEE   +  E+ +Q   
Sbjct: 1758 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1817

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR 481
                + +EL     R +   E  KR     ++  +      +  L E++AA+ +   L  
Sbjct: 1818 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877

Query: 482  EVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADG 541
            E E A K+ +E ++++ + +   EA +      RL   +  H                  
Sbjct: 1878 EAEIALKE-KEAENERLRRLAEDEAFQ----RRRLEEQAAQH------------------ 1914

Query: 542  HTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVS 601
              D     A LR+     L   R +     TL ++   R  +  +LA  A   ++ A  +
Sbjct: 1915 KADIEERLAQLRKASDSELE--RQKGLVEDTLRQR---RQVEEEILALKASFEKAAAGKA 1969

Query: 602  DGEDDRDTLLSSV-DLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEI 660
            + E +   + S+  D L    QA+   L    Q QL A  +  R   EE+      AEE 
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQAE---LEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026

Query: 661  ESRVGSGSLDNLGRFRS 677
             +R    +L+ + R ++
Sbjct: 2027 AARQRKAALEEVERLKA 2043



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 163/858 (18%), Positives = 315/858 (36%), Gaps = 116/858 (13%)

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEV- 158
            C +++ E+++  AE++        L    E +++  E S     ++ + +   G   +V 
Sbjct: 1046 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1105

Query: 159  -------EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLEEELGATHKELMILKE 208
                   E LK +  +    +  +E +R   E+L+ A    + L E L AT   L  L+ 
Sbjct: 1106 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE-LEATKASLKKLRA 1164

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE---EDLAKVIELQEIISKQS-- 263
            Q   ++   D + D     +       +R  +  +  E   E +A+++E  + +  Q+  
Sbjct: 1165 QAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDV 1224

Query: 264  --REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEER 321
              RE  Q+  +L         L   L  AR+   + + M     + VRE + Q++ + E 
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284

Query: 322  ITTLEKRYLAAQREATS-VHDLND--------KLENE-IANKDSMHRQTEDKNRQLQERL 371
            I    ++    QR A   ++ + D        K + E +A+     +        +QE +
Sbjct: 1285 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1344

Query: 372  ELAEQKLQQTLRKA-------ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE 424
            +L     + T   +       ETL  +E E  +R+A   +AEER     ERL ++EA LE
Sbjct: 1345 DLRTHYSELTTLTSQYIKFISETLRRMEEE--ERLAEQQRAEER-----ERLAEVEAALE 1397

Query: 425  EKNQ-----------------ELQRARQREKMNEE--------HNKRLSDTVDKLLSESN 459
            ++ Q                 ELQ+  Q E +  E          + + + + +L   S 
Sbjct: 1398 KQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE 1457

Query: 460  ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              +Q   ++  AA   +  +  E+   + QLE T+  +      ++ALRA  +    +  
Sbjct: 1458 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1517

Query: 520  SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNE---- 575
                    L      R  + D           L    K    A R++   +Q L E    
Sbjct: 1518 QAQEEAERL------RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQ 1571

Query: 576  ----------QDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADA 625
                       + ERA+Q  V    AQ   ++A++   +  R +       L  S Q + 
Sbjct: 1572 AEEAERRLRQAEVERARQVQVALETAQR-SAEAEL---QSKRASFAEKTAQLERSLQ-EE 1626

Query: 626  HTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSG-----SLDNLGRFRSMSS 680
            H     L+E+ +   ++    +  +E  E+  E  + +           + + + +S++ 
Sbjct: 1627 HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1686

Query: 681  IPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREE---VRDDKTTIK 737
                     A       G++  + +      E +      L   + ++      +   ++
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746

Query: 738  CETSPPSSPRAL---RLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSL 794
             ET      R L    L RL + A          +   +    +  V   S + + ++S 
Sbjct: 1747 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806

Query: 795  HKAPK-KKGIKSSIGRLFG-KKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQA 852
              + K K+ +++  GR     +E  R     +EA  Q  ++E D + Q          +A
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQ----------RA 1856

Query: 853  EKNRKLQKKHELLEEARR 870
            E  R L +K   + EA R
Sbjct: 1857 EAERVLAEKLAAIGEATR 1874



 Score = 40.0 bits (92), Expect = 0.013
 Identities = 79/315 (25%), Positives = 129/315 (40%), Gaps = 65/315 (20%)

Query: 243 LSHEEDLAKVIE----LQEIISKQSREQSQMKERL----ASLSSHVT-----ELEEDLDT 289
           L  E+ L    E    LQ I++K   E    +E+L    A L S V      ++ +    
Sbjct: 405 LEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGE 464

Query: 290 ARKDLIKSEEMNTKLQRDVREAM----AQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
             +DL K++ M   L  DV+        Q E M  R+  L +R +A + E       N +
Sbjct: 465 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE------YNLR 518

Query: 346 LENEIA---------NKDSMHRQTEDKN---RQLQERLELAEQKLQQTLRKAE---TLPE 390
           L+  +A            S+ R+ E ++   R LQ+ L   E+  Q  +  AE    LP 
Sbjct: 519 LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEEN-QHRVDGAEWGVDLPS 577

Query: 391 VEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDT 450
           VEA+L          EE    IE R R  E QL    +   R     +++ ++ K L+ +
Sbjct: 578 VEAQLGSHRGLHQSIEEFRAKIE-RARSDEGQLSPATRGAYRDCLG-RLDLQYAKLLNSS 635

Query: 451 VDKLLS----------ESNERLQLHLKER--------------MAALEDKNSLLREVESA 486
             +L S           + E + L+ KE                A  E  ++L+RE+E  
Sbjct: 636 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 695

Query: 487 KKQLEETQHDKDQLV 501
           +K+++E Q+  D+L+
Sbjct: 696 EKKIKELQNAGDRLL 710


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score = 98.2 bits (243), Expect = 4e-20
 Identities = 147/669 (21%), Positives = 289/669 (43%), Gaps = 64/669 (9%)

Query: 31   DADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEF 90
            +A +  E+ +   LEE +   + L+   ++ A  + +L +V        +QL  AL QE 
Sbjct: 661  EAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLE-ALQQEH 719

Query: 91   AALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKR---Q 147
              L K+L + +E L  RE+ +  L+   +  +  L  L+   +  E ++ +   ++   +
Sbjct: 720  LDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILE 779

Query: 148  AQSPAGVSSEVEVLKALKSLFEHHKALDE---KVRERLRVALERCSLLEEELGATHKELM 204
            A   A  S + E+ +  + L E  +   E   K+RE L +   +   L++E  A  K++ 
Sbjct: 780  AALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQ 839

Query: 205  ILKEQNNQKKTLTDGVLD--INHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQ 262
             +KEQ  Q+K + +       + +Q  +   + ++  D  L  +E   +++++       
Sbjct: 840  KIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSEL--KELRQELMQVHGEKRTA 897

Query: 263  SREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERI 322
              E S++   +A +  H+ +LE  L +A+K+  + E     LQ D  + +A  E  E   
Sbjct: 898  EAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANE--- 954

Query: 323  TTLEKRYLAAQREAT-SVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQT 381
              L+K+    Q+EA  ++ +   K+    ++  S  ++ + K++  +  + +  ++LQ+ 
Sbjct: 955  -ALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEA 1013

Query: 382  LRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLE---------EK------ 426
            L   E     +AEL Q + A   + +    + ER++ +EA+L+         EK      
Sbjct: 1014 LAAKEA---ADAELGQ-LRAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKELQEVI 1069

Query: 427  ---NQELQRARQR--EKMNEEHNKRLSDTVDKLLSESNERLQL---HLKERMAALEDKNS 478
               +QEL+ +R++  E  +E    R      K L ESN++L L   H K ++  L   N+
Sbjct: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELEHEKGKLTGLGQSNA 1129

Query: 479  LLREVESA-KKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFP 537
             LRE  S  +  L + + D  QL L ++A+   L         + H    L +  +    
Sbjct: 1130 ALREHNSILETALAKREADLVQLNLQVQAV---LQRKEEEDRQMKHLVQALQASLEKEKE 1186

Query: 538  MADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESD 597
              +   +  + + V     +    A   E S+V+       +  Q    L    QA   D
Sbjct: 1187 KVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVK-------KELQAKEHLVQKLQAEADD 1239

Query: 598  ADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKEN----T 653
              + +G+  ++      +L      A+A     +LQ+QLD    +  +  +E EN     
Sbjct: 1240 LQIREGKHSQEIAQFQAEL------AEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEV 1293

Query: 654  EQRAEEIES 662
            +Q+  EI+S
Sbjct: 1294 DQKEREIQS 1302



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 122/657 (18%), Positives = 267/657 (40%), Gaps = 40/657 (6%)

Query: 38   QLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKEL 97
            Q  V       +  D+L    +TL  +   L     +  ++    N +L    A+   +L
Sbjct: 450  QAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASL----ASSNNDL 505

Query: 98   NVCREQ---LLEREEEIAELKAERNNT-RLLLEHLECLVSRHERSL--RMTVVKRQAQSP 151
             V  EQ   L+ + E++      ++NT   L + +  L S+ ++    R T+  +   S 
Sbjct: 506  QVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565

Query: 152  AGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNN 211
            A +SS    L++++  ++   AL ++ R RL+  +    + +       + L +     +
Sbjct: 566  AEISS----LQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLS 621

Query: 212  QKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE----LQEIISKQSREQS 267
            Q+ T T      + +++   +   +      L  E    ++ E    ++E + ++  E  
Sbjct: 622  QQLTETQ---HRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFE 678

Query: 268  QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEK 327
              +ERL  ++     LE+ L+  +  L++ ++    LQ++  + M Q    +E + + E+
Sbjct: 679  GERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQ 738

Query: 328  RYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAET 387
               A Q     +     +L+ E A+++      +++   L+  L+ A+   ++  R A  
Sbjct: 739  SLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARR 798

Query: 388  LPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRL 447
            L E   E ++ +  L +         E L+Q  A L+++ Q+++    ++K+  E  +R 
Sbjct: 799  LEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRD 858

Query: 448  SDTVDKLLSE---SNERLQLHLK----ERMAALEDKNSLLREVESAKKQLEETQHDKDQL 500
            + + D+L+SE   + +RL   LK    E M    +K +   E+    +++ + +     L
Sbjct: 859  ATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADL 918

Query: 501  VLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMAD--GHTDSYSTSAVLRRPQK- 557
              ++++ + E D M     SL   +  + +V +    +          +  A+  + QK 
Sbjct: 919  EGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKM 978

Query: 558  GRLAALRDEPSKVQTLNEQDWE--------RAQQASVLANVAQAFESDADVSDGEDDRDT 609
             RL +      K      + +E        R Q+A      A A         G  D   
Sbjct: 979  RRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSL 1038

Query: 610  LL-SSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVG 665
             L   +  L    QA +H+  ++ +E  + I    + ++E +E   +  +E++   G
Sbjct: 1039 ALHERIQALEAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRG 1095



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 121/595 (20%), Positives = 233/595 (39%), Gaps = 57/595 (9%)

Query: 37   EQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKE 96
            +QL+  +   R RL   L+E ++ L    G+      E   L R++   + Q  A L   
Sbjct: 863  DQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV-AQVRQHMADLEGH 921

Query: 97   LNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMT--VVKRQAQSPAGV 154
            L   +++  E E  +  L+ ++     + E  E L  + E   +     +  Q Q    +
Sbjct: 922  LQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRL 981

Query: 155  SSEVEVLKALKSLFEHHKALDEKV---RERLRVALERCSLLEEELG-------------A 198
             S++    A K +   HKA +  V     RL+ AL      + ELG             A
Sbjct: 982  GSDLT--SAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLA 1039

Query: 199  THKELMILKEQN---NQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLA----- 250
             H+ +  L+ +    +  KTL +  L    E     S   + S +  L  E++L      
Sbjct: 1040 LHERIQALEAELQAVSHSKTLLEKELQ---EVIALTSQELEESREKVLELEDELQESRGF 1096

Query: 251  --KVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDV 308
              K+  L+E   K + E    K +L  L      L E        L K E    +L   V
Sbjct: 1097 RKKIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQV 1156

Query: 309  REAMAQKEDMEERITTLEKRYLAA-QREATSVHDLNDKLENEIANKDSMHRQTEDKNRQL 367
            +  + +KE+ + ++  L +   A+ ++E   V+ L +++           R  +  + +L
Sbjct: 1157 QAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLEL 1216

Query: 368  QE---RLELAEQKLQQTLRKAETLPEVEA----ELAQRVAALSKAEERHGNIEERL---- 416
             E    L+  E  +Q+   +A+ L   E     E+AQ  A L++A  +   ++++L    
Sbjct: 1217 SEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQL 1276

Query: 417  ----------RQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHL 466
                        ++ ++++K +E+Q  +Q+  + E+  ++  + + +LL      L++  
Sbjct: 1277 SKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQ 1336

Query: 467  KERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRP 526
            ++     +DK  L  +V   K  ++       QL L++    A+        AS  +   
Sbjct: 1337 EDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEASSSNPAT 1396

Query: 527  HLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERA 581
             +  +PD   P +          AV + P K   + L+    ++ +L  Q  E A
Sbjct: 1397 PI-KIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEEHA 1450



 Score = 41.2 bits (95), Expect = 0.006
 Identities = 74/394 (18%), Positives = 155/394 (39%), Gaps = 33/394 (8%)

Query: 292 KDLIKSEEMNTKLQ-RDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
           KD++++     + Q ++V   +  + D      +LE      Q E   V     +LE ++
Sbjct: 362 KDVLQAAAAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQL 421

Query: 351 ANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHG 410
                   Q   +  +LQ +L     KLQ  +  + +  + +  L+  V  L   ++   
Sbjct: 422 EALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTL---KQSCW 478

Query: 411 NIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE--SNERLQLHLKE 468
           ++E  +  ++  LE KN  L  +    ++ EE  +RL   V+ +     S +     L++
Sbjct: 479 DLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQ 538

Query: 469 RMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALR---------AELDHMRLRGA 519
           +M AL+   S L++V+  +  L          + +++++R         A+   +RL+G 
Sbjct: 539 QMTALQ---SQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGE 595

Query: 520 SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRR--PQKGRLAALRDEPSKVQTLNEQD 577
             H     +           +  + S   +    R   +KGR+AA            E  
Sbjct: 596 MAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAA 655

Query: 578 WERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQ--EQ 635
           + + Q+A  +       +    + + E +R+ L    D  +   Q        +LQ  +Q
Sbjct: 656 FMQIQEAKTMVEE----DLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQ 711

Query: 636 LDAIN-------KEIRLIQEEKENTEQRAEEIES 662
           L+A+        K++ L QE  ++ EQ  + +++
Sbjct: 712 LEALQQEHLDLMKQLTLTQEALQSREQSLDALQT 745



 Score = 40.8 bits (94), Expect = 0.008
 Identities = 56/288 (19%), Positives = 113/288 (39%), Gaps = 26/288 (9%)

Query: 242 SLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
           SL   + L +  ELQ  ++  S +     E   S       L  ++DT ++     E   
Sbjct: 425 SLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAM 484

Query: 302 TKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTE 361
           T LQ  +    A        +   E++Y   QR    V D+   +   ++  +++H    
Sbjct: 485 TDLQNMLEAKNASLASSNNDLQVAEEQY---QRLMAKVEDMQRSM---LSKDNTVH---- 534

Query: 362 DKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
                L++++   + +LQQ   +  TL          +++L    + +       ++   
Sbjct: 535 ----DLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARV 590

Query: 422 QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAA--------L 473
           +L+ +   +Q  +  +    EH K  + ++ + L+E+  R  +  K R+AA        +
Sbjct: 591 RLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHR-SMKEKGRIAAQLQGIEADM 649

Query: 474 EDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASL 521
            D+ +   +++ AK  +EE   D  + +   E  R  L  M    ASL
Sbjct: 650 LDQEAAFMQIQEAKTMVEE---DLQRRLEEFEGERERLQRMADSAASL 694


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 97.8 bits (242), Expect = 5e-20
 Identities = 154/677 (22%), Positives = 289/677 (42%), Gaps = 100/677 (14%)

Query: 44   LEERDRLLDTLRETQETLALTQGKLHEVGHERDSL---QRQLNTALPQEFAALTKELNVC 100
            L+    L     E +  L   + +L E+ H+ ++    + +    L  E   + + +   
Sbjct: 889  LQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQEL 948

Query: 101  REQLLEREEEIAELKAERNNT----------RLLLEHLECLVSRHERSLRMTVVKRQAQS 150
             EQL E E    +L+ E+  T          +++LE   C +++ ++ L      R A+ 
Sbjct: 949  EEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE----DRIAEF 1004

Query: 151  PAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQN 210
               ++ E E  K+L  L   H+A+   + ERLR    R     +EL  T ++L       
Sbjct: 1005 TTNLTEEEEKSKSLAKLKNKHEAMITDLEERLR----REEKQRQELEKTRRKL------E 1054

Query: 211  NQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMK 270
                 L+D + ++  +         K+        EE+L   +     + +++ +++   
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKK--------EEELQAALAR---VEEEAAQKNMAL 1103

Query: 271  ERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAM-AQKEDMEERI-TTLEKR 328
            +++  L S ++EL+EDL++ R    K+E    K +RD+ E + A K ++E+ + +T  ++
Sbjct: 1104 KKIRELESQISELQEDLESERASRNKAE----KQKRDLGEELEALKTELEDTLDSTAAQQ 1159

Query: 329  YLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQ-----KLQQTLR 383
             L ++RE   V+ L   LE E    ++  ++   K+ Q  E  ELAEQ     +++  L 
Sbjct: 1160 ELRSKRE-QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVKANLE 1216

Query: 384  KA-ETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE---KNQELQRARQREKM 439
            KA +TL     ELA  V  L + +   G+ E + +++EAQL+E   K  E +R R     
Sbjct: 1217 KAKQTLENERGELANEVKVLLQGK---GDSEHKRKKVEAQLQELQVKFNEGERVRTELAD 1273

Query: 440  NEEHNKRLSDTVDKLLSESNERLQLHLKERMA---ALEDKNSLLREVE----SAKKQLEE 492
                 +   D V  LLS+S+ +     K+  A    L+D   LL+E      S   +L++
Sbjct: 1274 KVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQ 1333

Query: 493  TQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVL 552
             + +K+     +E       ++  + A+LH        V D +  M D      +   V 
Sbjct: 1334 VEDEKNSFREQLEEEEEAKHNLEKQIATLH------AQVADMKKKMEDSVGCLETAEEVK 1387

Query: 553  RRPQKGRLAALRDEPSKVQTLN--EQDWERAQQA--SVLANVAQAFESDADVSDGEDDRD 608
            R+ QK      +    KV   +  E+   R QQ    +L ++    +S  ++   +   D
Sbjct: 1388 RKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFD 1447

Query: 609  TLLSSVDLLSPS-------GQADAH-------TLAMMLQE------QLDAINKEIRLIQE 648
             LL+    +S          +A+A        +LA  L+E      +L+ +NK+ R   E
Sbjct: 1448 QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEME 1507

Query: 649  E----KENTEQRAEEIE 661
            +    K++  +   E+E
Sbjct: 1508 DLMSSKDDVGKSVHELE 1524



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 146/687 (21%), Positives = 295/687 (42%), Gaps = 94/687 (13%)

Query: 50   LLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREE 109
            L D + E Q  +A  + +L +   E  +   ++     Q+  AL K++     Q+ E +E
Sbjct: 1060 LSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMAL-KKIRELESQISELQE 1118

Query: 110  EIAELKAERNNT----RLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALK 165
            ++   +A RN      R L E LE L +  E +L  T  +++ +S      EV +LK  K
Sbjct: 1119 DLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKR--EQEVNILK--K 1174

Query: 166  SLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINH 225
            +L E  K  + +++E  +   +    L E+L  T +    L++    K+TL +   ++ +
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA---KQTLENERGELAN 1231

Query: 226  EQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEE 285
            E +      GK  S+      E  A++ ELQ   ++  R ++++ ++       VT+L+ 
Sbjct: 1232 EVKVL--LQGKGDSEHKRKKVE--AQLQELQVKFNEGERVRTELADK-------VTKLQV 1280

Query: 286  DLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDK 345
            +LD     L +S+  ++KL +D     +Q +D +E +    ++ L+   +   V D  + 
Sbjct: 1281 ELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS 1340

Query: 346  LENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL---------- 395
               ++  ++      E +   L  ++   ++K++ ++   ET  EV+ +L          
Sbjct: 1341 FREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR 1400

Query: 396  -AQRVAALSKAEERHGNIEERL----------RQMEAQLEEKNQEL-------------- 430
              ++VAA  K E+    +++ L          RQ    LE+K ++               
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKY 1460

Query: 431  --QRARQREKMNEEHNKRLS------DTVDKL--LSESNERLQLHLKERMAALED----- 475
              +R R   +  E+  K LS      + +++   L   N++ +  +++ M++ +D     
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSV 1520

Query: 476  ------KNSLLREVESAKKQLEE-------TQHDKDQLVLNIEALRAELDHMRLRGASLH 522
                  K +L ++VE  K QLEE       T+  K +L +N++A++A+ +   L+G    
Sbjct: 1521 HELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER-DLQGRDEQ 1579

Query: 523  HGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQ 582
                    V   R   A+   +    S  +   +K  +  L+D  + + + N+   E  +
Sbjct: 1580 SEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEM-DLKDLEAHIDSANKNRDEAIK 1638

Query: 583  QASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKE 642
            Q   L   AQ  +   ++ D    R+ +L+     +           + LQE+L A  + 
Sbjct: 1639 QLRKLQ--AQMKDCMRELDDTRASREEILAQAK-ENEKKLKSMEAEMIQLQEELAAAERA 1695

Query: 643  IRLIQEEKENTEQRAEEIESRVGSGSL 669
             R  Q+E+   ++ A+EI +  G G+L
Sbjct: 1696 KRQAQQER---DELADEIANSSGKGAL 1719



 Score = 89.4 bits (220), Expect = 2e-17
 Identities = 152/722 (21%), Positives = 292/722 (40%), Gaps = 120/722 (16%)

Query: 21   GHGSGSPSQPDADSHFEQLMVSMLEE---RDRLLDTLRETQETLALTQGKLHEVGHERDS 77
            G G     +   ++  ++L V   E    R  L D + + Q  L    G L +   +   
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSK--- 1295

Query: 78   LQRQLNTALPQEFAALTKELNVCREQLLEREEE-------IAELKAERNNTRLLLEHLEC 130
                 ++ L ++F+AL  +L   +E L E   +       + +++ E+N+ R  LE  E 
Sbjct: 1296 -----SSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEE 1350

Query: 131  LVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCS 190
                 E+ +  T+  + A     +   V  L+             E+V+ +L+  LE  S
Sbjct: 1351 AKHNLEKQIA-TLHAQVADMKKKMEDSVGCLETA-----------EEVKRKLQKDLEGLS 1398

Query: 191  LLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLA 250
               EE  A + +L   K +  Q+  L D ++D++H++++  +   K+     L  EE   
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQE--LDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE--- 1453

Query: 251  KVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVRE 310
                 + I +K + E+ + +       +    L   L+ A +   + E +N + + ++ +
Sbjct: 1454 -----KTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508

Query: 311  AMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI-----------ANKDSMHRQ 359
             M+ K+D+ + +  LEK   A +++   +    ++LE+E+            N  +M  Q
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQ 1568

Query: 360  TEDKNRQLQERLELAEQKLQQTLRKAETLP-EVEAELAQR---VAALSKAEERHGNIE-- 413
             E   R LQ R E +E+K +Q +R+   +  E+E E  QR   VAA  K E    ++E  
Sbjct: 1569 FE---RDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH 1625

Query: 414  ------------ERLRQMEAQLEEKNQELQRAR-QREKM---NEEHNKRLSDTVDKLLSE 457
                        ++LR+++AQ+++  +EL   R  RE++    +E+ K+L     +++  
Sbjct: 1626 IDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQL 1685

Query: 458  SNERLQLHLKERMA--------------------ALEDKNSLLREVESAKKQLEETQHDK 497
              E       +R A                    ALE+K  L   +   +++LEE Q + 
Sbjct: 1686 QEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745

Query: 498  DQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTD----SYSTSAVLR 553
            + +   ++    ++D +      L+  R H     + R  +   + +           ++
Sbjct: 1746 ELINDRLKKANLQIDQI---NTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVK 1802

Query: 554  RPQKGRLAALRDEPSKVQTLNEQ-DWERAQQASVLANVAQAFESDADVSDGEDDRDTLLS 612
               K  + AL    +K+  L EQ D E  ++ +    V +  +   DV    DD      
Sbjct: 1803 SKYKASITALE---AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE 1859

Query: 613  SVDLLSPSGQAD-AHTLAMMLQEQLDAINKEI-------RLIQEEKENTEQRAEEIESRV 664
                     QAD A T    L+ QL+   +E        R +Q E E+  + A+ +   V
Sbjct: 1860 QY-----KDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREV 1914

Query: 665  GS 666
             S
Sbjct: 1915 SS 1916



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 101/475 (21%), Positives = 210/475 (44%), Gaps = 44/475 (9%)

Query: 231  PSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTA 290
            P     R  +  ++ EE+L KV E Q  ++ ++R  ++M+   + L +   +L+E L   
Sbjct: 836  PLLQVSRQEEEMMAKEEELVKVREKQ--LAAENR-LTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 291  RKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKR--YLAAQRE--ATSVHDLNDKL 346
             +   ++EE+  +L    +E      D+E R+   E+R  +L A+++    ++ +L ++L
Sbjct: 893  TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQL 952

Query: 347  ENEIANKDSMHRQ---TEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS 403
            E E + +  +  +   TE K ++L+E   + E    Q  + A+    +E  +A+    L+
Sbjct: 953  EEEESARQKLQLEKVTTEAKLKKLEEEQIILE---DQNCKLAKEKKLLEDRIAEFTTNLT 1009

Query: 404  KAEERHGNIEERLRQMEAQLEEKNQELQR-ARQREKMNEEHNKRLSDTVDKLLSESNERL 462
            + EE+  ++ +   + EA + +  + L+R  +QR+++ +   K   D+ D  LS+    L
Sbjct: 1010 EEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTD--LSDQIAEL 1067

Query: 463  QLHLKERMAALEDKNSLLREVESAKKQLEETQHDKD-------QLVLNIEALRAELDHMR 515
            Q  + E    L  K     E+++A  ++EE    K+       +L   I  L+ +L+  R
Sbjct: 1068 QAQIAELKMQLAKKE---EELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESER 1124

Query: 516  LRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALR---DEPSKVQT 572
                     +  LG   +      +   DS +    LR  ++  +  L+   +E +K   
Sbjct: 1125 ASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHE 1184

Query: 573  LNEQDWERAQQASVLANVAQAFESDADVSDG--------EDDRDTLLSSVDLLSPSGQAD 624
               Q+  R + +  +  +A+  E    V           E++R  L + V +L   G+ D
Sbjct: 1185 AQIQEM-RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL-QGKGD 1242

Query: 625  AHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMS 679
            +      ++ QL  +  +++  + E+  TE   +  + +V    LDN+    S S
Sbjct: 1243 SEHKRKKVEAQLQEL--QVKFNEGERVRTELADKVTKLQV---ELDNVTGLLSQS 1292



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 101/485 (20%), Positives = 203/485 (41%), Gaps = 86/485 (17%)

Query: 249  LAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM-------N 301
            +A+ ++LQE +  ++   ++ +E  A L++   ELEE        + + EE         
Sbjct: 879  MAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEK 938

Query: 302  TKLQRDVREAMAQKEDME--------ERITTLEKRYLAAQREATSVHDLNDK-------L 346
             K+Q++++E   Q E+ E        E++TT E +    + E   + D N K       L
Sbjct: 939  KKMQQNIQELEEQLEEEESARQKLQLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLL 997

Query: 347  ENEIANKDSMHRQTEDKNR--------------QLQERL---ELAEQKLQQTLRKAE--- 386
            E+ IA   +   + E+K++               L+ERL   E   Q+L++T RK E   
Sbjct: 998  EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057

Query: 387  -----TLPEVEAELAQRVAALSKAEER----HGNIEE----------RLRQMEAQLEEKN 427
                  + E++A++A+    L+K EE        +EE          ++R++E+Q+ E  
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117

Query: 428  QELQRARQREKMNEEHNKRLSDTVDKLLSESNERL-------QLHLKERMAALEDKNSLL 480
            ++L+  R      E+  + L + ++ L +E  + L       +L  K        K +L 
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLE 1177

Query: 481  REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHL----GSVPDFRF 536
             E ++ + Q++E +    Q V   E L  +L+  +   A+L   +  L    G + +   
Sbjct: 1178 EEAKTHEAQIQEMRQKHSQAV---EELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234

Query: 537  PMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFES 596
             +  G  DS       R+  + +L  L+ +       NE +  R + A  +  +    ++
Sbjct: 1235 VLLQGKGDSEHK----RKKVEAQLQELQVK------FNEGERVRTELADKVTKLQVELDN 1284

Query: 597  DADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQR 656
               +    D + + L+       S   D   L      Q  +++ +++ +++EK +  ++
Sbjct: 1285 VTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQ 1344

Query: 657  AEEIE 661
             EE E
Sbjct: 1345 LEEEE 1349



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 73/352 (20%), Positives = 138/352 (39%), Gaps = 39/352 (11%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLH----EVGHERDSLQRQLNTALPQEFAALTK 95
            +V  + E +  L+  R+ +      + KL     ++    DS  +  + A+ Q    L  
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQ-LRKLQA 1645

Query: 96   ELNVCREQLLEREEEIAELKAERNNTRLLLEHLEC-LVSRHERSLRMTVVKRQAQSPAGV 154
            ++  C  +L +      E+ A+       L+ +E  ++   E        KRQAQ     
Sbjct: 1646 QMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDE 1705

Query: 155  SSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKK 214
             ++     + K       AL+EK R   R+A +    LEEE G T      LK+ N Q  
Sbjct: 1706 LADEIANSSGKGAL----ALEEKRRLEARIA-QLEEELEEEQGNTELINDRLKKANLQID 1760

Query: 215  TL-TDGVLDINHEQENTPSTS-----------------GKRSSDGSLSHEEDLAKVIELQ 256
             + TD  L+ +H Q+N  +                   G   S    S     AK+ +L+
Sbjct: 1761 QINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE 1820

Query: 257  EIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKE 316
            E +  +++E+    +++      + ++   +D  R++  + ++   K    +++   Q E
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLE 1880

Query: 317  DMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQ 368
            + EE           AQR   S   L  +LE+     D+M+R+      +L+
Sbjct: 1881 EAEEE----------AQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 134/572 (23%), Positives = 258/572 (45%), Gaps = 67/572 (11%)

Query: 37   EQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLN--TALPQEFAALT 94
            E+ MV++++E++ L   ++   + LA  + +  ++   +  L+ ++   T   ++   + 
Sbjct: 878  EEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEIN 937

Query: 95   KELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGV 154
             EL   + +L   E+E +ELK + ++  L L  +E      E+      VK   +  AG+
Sbjct: 938  AELTAKKRKL---EDECSELKKDIDDLELTLAKVE-----KEKHATENKVKNLTEEMAGL 989

Query: 155  SSEVEVL-KALKSLFE-HHKALDEKVRE--RLRVALERCSLLEEEL----GATHKELMIL 206
               +  L K  K+L E H + LD+   E  ++    +  + LE+++    G+  +E  + 
Sbjct: 990  DETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLC 1049

Query: 207  KEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQ 266
             +    K+ L     D+   QE+T  T     +D    +E+   K  E+  +  K   EQ
Sbjct: 1050 MDLERAKRKLEG---DLKLAQESTMDTE----NDKQQLNEKLKKKEFEMSNLQGKIEDEQ 1102

Query: 267  S---QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDM----E 319
            +   Q+++++  L + + ELEE+++  R    K+E+  + L R++ E   + E+      
Sbjct: 1103 ALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162

Query: 320  ERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQ 379
             +I   +KR    Q+      DL +      A   ++ ++  D   +L E+++ + Q+++
Sbjct: 1163 AQIEMNKKREAEFQKMR---RDLEESTLQHEATAAALRKKHADSVAELGEQID-SLQRVK 1218

Query: 380  QTLRKAETLPEVEA-ELAQRVAALSKAEERHGNIEERLRQMEAQLEE---KNQELQRARQ 435
            Q L K ++  ++E  +LA  +  +SKA+    N E+  R +E QL E   K +E QR   
Sbjct: 1219 QKLEKEKSELKMEINDLASNMETVSKAK---ANFEKMCRTLEDQLSEIKTKEEEQQRL-- 1273

Query: 436  REKMNEEHNKRLSDTVDKLLSESNE-RLQLHLKERMAAL--EDKNSLLREVESAKKQLEE 492
               +NE     LS    +L +ES E   QL  K+ M +     K +  +++E  K+QLEE
Sbjct: 1274 ---INE-----LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEE 1325

Query: 493  TQHDKDQLVLNIEALRAELDHMRLR-------GASLHHGRPHLGS-VPDFRFPMADGHTD 544
                K  L   +++ R + D +R +        A L  G     S V  +R       TD
Sbjct: 1326 ETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR---TKYETD 1382

Query: 545  SYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQ 576
            +   +  L   +K     L+D    V+ +N +
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 108/591 (18%), Positives = 236/591 (39%), Gaps = 50/591 (8%)

Query: 86   LPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVV 144
            + +EF    +EL     +  E EE++  L  E+N+ +L ++   + L    ER  ++   
Sbjct: 856  MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKT 915

Query: 145  KRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELM 204
            K Q ++          +K +    E  + ++ ++  + R   + CS L++++       +
Sbjct: 916  KIQLEAK---------IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLE---L 963

Query: 205  ILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSR 264
             L +   +K    + V ++  E      T  K + +     E     + +LQ     +  
Sbjct: 964  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ----MEED 1019

Query: 265  EQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITT 324
            + + + +    L   V +LE  L+  +K  +  E    KL+ D++ A     D E     
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQ 1079

Query: 325  LEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRK 384
            L ++    + E ++       L+ +I ++ ++  Q + K ++LQ R+E  E++++     
Sbjct: 1080 LNEKLKKKEFEMSN-------LQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS 1132

Query: 385  AETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEH- 443
                 +  ++L++ +  +S+  E  G       +M  + E + Q+++R  +   +  E  
Sbjct: 1133 RAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEAT 1192

Query: 444  ----NKRLSDTVDKL------LSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEET 493
                 K+ +D+V +L      L    ++L+    E    + D  S +  V  AK   E+ 
Sbjct: 1193 AAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKM 1252

Query: 494  QHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLR 553
                +  +  I+    E   + +   S    R H  S         +         A++ 
Sbjct: 1253 CRTLEDQLSEIKTKEEEQQRL-INELSAQKARLHTES--------GEFSRQLDEKDAMVS 1303

Query: 554  RPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSS 613
            +  +G+ A  +    +++ L  Q  E  +  S LA+  Q+   D D+   E   +   + 
Sbjct: 1304 QLSRGKQAFTQ----QIEELKRQLEEETKAKSTLAHALQSARHDCDLL-REQYEEEQEAK 1358

Query: 614  VDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRV 664
             +L     +A++       + + DAI +   L +E K+   QR ++ E  V
Sbjct: 1359 AELQRGMSKANSEVAQWRTKYETDAIQRTEEL-EEAKKKLAQRLQDAEEHV 1408



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 129/672 (19%), Positives = 268/672 (39%), Gaps = 70/672 (10%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQL 104
            EE+ RL++ L   +  L    G+      E+D++  QL+    Q F    +EL    E+ 
Sbjct: 1268 EEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG-KQAFTQQIEELKRQLEEE 1326

Query: 105  LEREEEIAE-LKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSS-----EV 158
             + +  +A  L++ R++  LL E  E      E+  +  + +  +++ + V+      E 
Sbjct: 1327 TKAKSTLAHALQSARHDCDLLREQYE-----EEQEAKAELQRGMSKANSEVAQWRTKYET 1381

Query: 159  EVLKALKSLFEHHKALDEKVR---ERLRVALERCSLLE---EELGATHKELMILKEQNN- 211
            + ++  + L E  K L ++++   E +     +C+ LE   + L    ++LMI  E++N 
Sbjct: 1382 DAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA 1441

Query: 212  --------------------QKKTLTDGVLDINHEQENTPSTS---GKRSSDGSLSHEED 248
                                QK   T   L+ + ++  + ST     K + + SL H E 
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET 1501

Query: 249  LAK--------VIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEM 300
            L +        + +L E I++  +   ++++    L    +EL+  L+ A   L   E  
Sbjct: 1502 LKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGK 1561

Query: 301  NTKLQRDVREAMAQKE----DMEERITTLEKRYLAAQREATSVHDLNDKLENEIAN-KDS 355
              ++Q ++ +  ++ +    + +E +  L++ +L       S  D   +  N+    K  
Sbjct: 1562 ILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKK 1621

Query: 356  MHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEER 415
            M     +   QL      A + L+        L + +  L   +      +E+   +E R
Sbjct: 1622 MEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERR 1681

Query: 416  LRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALED 475
               M+A++EE    L+R  +  KM E+     S+ V +LL   N  L ++ K+++    D
Sbjct: 1682 ANLMQAEVEELRASLERTERGRKMAEQELLDASERV-QLLHTQNTSL-INTKKKLET--D 1737

Query: 476  KNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLG-SVPDF 534
             + +  E+E   ++    +    + + +   +  EL   +   A L   + ++  +V D 
Sbjct: 1738 ISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1797

Query: 535  RFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWE--RAQQASVLANVAQ 592
            +  + +    +        +  + R+  L  E    Q  N +  +  R  +  V     Q
Sbjct: 1798 QLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQ 1857

Query: 593  AFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKEN 652
              E   ++   +D  D L + V       +          +EQ +    + R +Q E E 
Sbjct: 1858 TEEDRKNILRLQDLVDKLQTKVKAYKRQAEE--------AEEQSNVNLAKFRKLQHELEE 1909

Query: 653  TEQRAEEIESRV 664
             ++RA+  ES+V
Sbjct: 1910 AKERADIAESQV 1921



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 90/496 (18%), Positives = 203/496 (40%), Gaps = 51/496 (10%)

Query: 199  THKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEI 258
            T KE+  +KE+  + K           E E    T  +  +D  L  + +   + + +E 
Sbjct: 849  TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEER 908

Query: 259  ISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDM 318
              +  + + Q++ ++      VTE  ED           EE+N +L    R+   +  ++
Sbjct: 909  CDQLIKTKIQLEAKI----KEVTERAED----------EEEINAELTAKKRKLEDECSEL 954

Query: 319  EERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKL 378
            ++ I  LE      ++E  +  +    L  E+A  D    +   + + LQE  +     L
Sbjct: 955  KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL 1014

Query: 379  QQTLRKAETLPEVEAELAQRVAALSKAEERHG----NIEERLRQMEAQLE-EKNQELQRA 433
            Q    K  TL + + +L Q+V  L  + E+      ++E   R++E  L+  +   +   
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTE 1074

Query: 434  RQREKMNEEHNKR---LSDTVDKLLSESNERLQLH--LKERMAALEDKNSLLREVESAKK 488
              ++++NE+  K+   +S+   K+  E    +QL   +KE  A +E+   L  E+E+ + 
Sbjct: 1075 NDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEE---LEEEIEAERA 1131

Query: 489  QLEETQHDKDQLVLNIEALRAELDHM-RLRGASLHHGRPHLGSVPDFRFPMADGHTDSYS 547
               + +  +  L   +E +   L+       A +   +         R  + +      +
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEA 1191

Query: 548  TSAVLRRPQKGRLAALRDEPSKVQTLNEQ-DWERAQQASVLANVAQAFESD--------- 597
            T+A LR+     +A L ++   +Q + ++ + E+++    + ++A   E+          
Sbjct: 1192 TAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEK 1251

Query: 598  ---------ADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQE 648
                     +++   E+++  L++ +     + +A  HT +     QLD  +  +  +  
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINELS----AQKARLHTESGEFSRQLDEKDAMVSQLSR 1307

Query: 649  EKENTEQRAEEIESRV 664
             K+   Q+ EE++ ++
Sbjct: 1308 GKQAFTQQIEELKRQL 1323



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 102/461 (22%), Positives = 188/461 (40%), Gaps = 109/461 (23%)

Query: 76   DSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRH 135
            ++L+R+ N  L QE + LT+++    + + E E+   +L  E++  +  LE  E  +   
Sbjct: 1500 ETLKRE-NKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHE 1558

Query: 136  E-RSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEE 194
            E + LR+ +   Q      V SE++     + + E  + LD+  R  LRV     S L+ 
Sbjct: 1559 EGKILRIQLELNQ------VKSEID-----RKIAEKDEELDQLKRNHLRVVESMQSTLDA 1607

Query: 195  ELGATHKELMILKEQNNQKKTLTDGVLDINH-EQENTPSTSGKRSSDGSLSHEEDLAKVI 253
            E+ + +  L I K+       L +  + +NH  ++   +    R++ G L   +     +
Sbjct: 1608 EIRSRNDALRIKKKMEGD---LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQ-----L 1659

Query: 254  ELQEIISKQS--REQSQMKERLASL-SSHVTELEEDLDT-------ARKDLIKSEE---- 299
             L + I  Q   +EQ  M ER A+L  + V EL   L+        A ++L+ + E    
Sbjct: 1660 HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQL 1719

Query: 300  --------MNTK--LQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENE 349
                    +NTK  L+ D+ +   + ED+ +     E++   A  +A  + +   K ++ 
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779

Query: 350  IANKDSMHRQTEDKNRQLQERLELAEQ-----------KLQQTLRKAETLPEVEAELAQR 398
             A+ + M +  E   + LQ RL+ AEQ           KL+  +R+ E+  EVE+E    
Sbjct: 1780 SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELES--EVESEQKHN 1837

Query: 399  VAALSKAEERHGNIEE-------------------------------------------- 414
            V A+    +    ++E                                            
Sbjct: 1838 VEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNL 1897

Query: 415  -RLRQMEAQLEEKNQ-----ELQRARQREKMNEEHNKRLSD 449
             + R+++ +LEE  +     E Q  + R K  E H K +S+
Sbjct: 1898 AKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 47/262 (17%), Positives = 122/262 (46%), Gaps = 29/262 (11%)

Query: 274  ASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQ 333
            A     +  ++E+ +  +++L K+E    +L+  +   M +K D++          L  Q
Sbjct: 847  AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQ----------LQVQ 896

Query: 334  REATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEA 393
             EA ++ D  ++ +  I  K  +  + ++   + ++  E+  +   +  +  +   E++ 
Sbjct: 897  AEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKK 956

Query: 394  ELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQR-ARQREKMNEEHNKRLSD--- 449
            ++      L+K E+     E +++ +  ++   ++ + +  ++++ + E H + L D   
Sbjct: 957  DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQM 1016

Query: 450  TVDKL--LSESNERLQLHLKERMAALEDKNSLLREVESAKKQLE-----------ETQHD 496
              DK+  L+++  +L+  + +   +LE +  L  ++E AK++LE           +T++D
Sbjct: 1017 EEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTEND 1076

Query: 497  KDQLVLNIEALRAELDHMRLRG 518
            K Q  LN +  + E +   L+G
Sbjct: 1077 KQQ--LNEKLKKKEFEMSNLQG 1096



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 62/315 (19%), Positives = 131/315 (41%), Gaps = 26/315 (8%)

Query: 51   LDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEE 110
            L  LR TQ  L  TQ  L +    +D L+ QL        A + +  N+ + ++ E    
Sbjct: 1644 LRNLRNTQGILKDTQLHLDDAIRGQDDLKEQL--------AMVERRANLMQAEVEELRAS 1695

Query: 111  IAELKAERNNTRL-LLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFE 169
            +   +  R      LL+  E +   H ++  +   K++ ++        ++   ++ + +
Sbjct: 1696 LERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDIS-----QIQGEMEDIVQ 1750

Query: 170  HHKALDEKVRERLR-VALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQE 228
              +  +EK ++ +   A+    L +E+  + H E M    + N ++T+ D  L ++ E E
Sbjct: 1751 EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM----KKNMEQTVKDLQLRLD-EAE 1805

Query: 229  NTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLD 288
                  GK+        ++  A+V EL+  +  + +   +  + L      V EL    +
Sbjct: 1806 QLALKGGKKQI------QKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTE 1859

Query: 289  TARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLEN 348
              RK++++ +++  KLQ  V+    Q E+ EE+      ++   Q E     +  D  E+
Sbjct: 1860 EDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIAES 1919

Query: 349  EIANKDSMHRQTEDK 363
            ++       R+   K
Sbjct: 1920 QVNKLRVKSREVHTK 1934


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 133/626 (21%), Positives = 251/626 (40%), Gaps = 63/626 (10%)

Query: 96   ELNVCREQLLEREEEIAELKA-------ERNNTRLLLEHLECLVSRHERSL---RMTVVK 145
            E+ +  EQ+  ++EEI +L++       ERN  RL  + LE  +S     L   R T   
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES 1307

Query: 146  RQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVR----ERLRVALERCSLLEEELGATH- 200
                  A  +  +   K +K L   + AL +++     E +   L R + +  E+     
Sbjct: 1308 ASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA 1367

Query: 201  ------KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE 254
                  K    ++E +  KK L     D    ++       +R  D     EE    + +
Sbjct: 1368 GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427

Query: 255  LQEIISKQSREQSQMKERLASLSSHVTELEE-------DLDTARKDLIKSEEMNTKLQRD 307
            L++   + + E    K  L        ELE+       +L  A ++  + +    KLQR+
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487

Query: 308  ----VREAMAQKEDMEER---ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
                + EA + K+ +EE+   I    ++ ++ + E   +     K E  +A      R  
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547

Query: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS------KAEERHGNIEE 414
            E K +  +E L+     +Q  L +A+   E+E E  ++  +        + EE   + ++
Sbjct: 1548 EAKVKDQEEELDEQAGTIQM-LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQK 1606

Query: 415  RLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALE 474
            +L+QME QLEE+ ++ Q+  + ++  E     LSD V++   ES +RL+  LK   A L 
Sbjct: 1607 KLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA 1666

Query: 475  DKNSLL----------REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHG 524
            D   +L          RE+   K QLEE++      V   +A+  E++ + L+   +   
Sbjct: 1667 DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKA 1726

Query: 525  R----PHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWER 580
            +      L  +   +  + +   +       L +  K  +A    + +++  L  Q  E 
Sbjct: 1727 KTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA 1786

Query: 581  AQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAIN 640
             ++   L    QA +S  +  +      +L+S         +A    L   L+ +   + 
Sbjct: 1787 NKEKQELQEKLQALQSQVEFLEQSMVDKSLVS-------RQEAKIRELETRLEFERTQVK 1839

Query: 641  KEIRLIQEEKENTEQRAEEIESRVGS 666
            +   L    KEN E+  EE + R+ +
Sbjct: 1840 RLESLASRLKENMEKLTEERDQRIAA 1865



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/534 (23%), Positives = 224/534 (41%), Gaps = 81/534 (15%)

Query: 32   ADSHFEQLMVSMLEER-DRLLDTLRETQETLALTQGKLHEV-------------GHERDS 77
            ADS   Q  +  L+++  RL   L++T+  L   Q + HE+              HE   
Sbjct: 1416 ADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ 1475

Query: 78   LQRQLNTALPQEFAALTKELNVCREQLLEREEEIA-------ELKAERNN---------- 120
             ++     L +E   L  E    ++QL E++ +IA        L+AE  +          
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1535

Query: 121  ----TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDE 176
                 +  L  LE  V   E  L       Q    A +  E+E+ +  ++  +  ++ DE
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595

Query: 177  KVRERLRVALERCS----LLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPS 232
            +V E  +   ++       LEEE     K L   +E   +  TL+D V   + E E    
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655

Query: 233  TSGKRS----SDGSLSHEEDLAKVIELQEIIS-KQSREQSQMKERLASLSSHVTELE-ED 286
               KR+    +D  L  +         +EI   K   E+S+     A  +    E+E ED
Sbjct: 1656 KDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIED 1715

Query: 287  LDTARKDLIKS----EEMNTKLQRDVREAMAQKEDMEERITTLEKRYLA----AQREATS 338
            L     D+ K+    EE  ++LQR+  E   + E+ +E +  L K++ A    A R+   
Sbjct: 1716 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1775

Query: 339  VHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQR 398
            ++DL  +LE   ANK+   ++ ++K + LQ ++E  EQ +            V+  L   
Sbjct: 1776 INDLQAQLEE--ANKEK--QELQEKLQALQSQVEFLEQSM------------VDKSL--- 1816

Query: 399  VAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR-EKMNEEHNKRLSDTVDKLLSE 457
               +S+ E +   +E RL     Q++       R ++  EK+ EE ++R++   +    E
Sbjct: 1817 ---VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIA--AENREKE 1871

Query: 458  SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAEL 511
             N+RLQ  L++     E+   L R+   A ++  E + D + L    ++L+A+L
Sbjct: 1872 QNKRLQRQLRD---TKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADL 1922



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 98/484 (20%), Positives = 207/484 (42%), Gaps = 58/484 (11%)

Query: 44   LEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQ 103
            LEE+D  +D    TQ+ ++L + +L ++  +    +  L        A + K+L     +
Sbjct: 1502 LEEKD--MDIAGFTQKVVSL-EAELQDISSQESKDEASL--------AKVKKQLRDLEAK 1550

Query: 104  LLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKA 163
            + ++EEE+ E    +  T  +LE  +  +      +R T  K        V    +  + 
Sbjct: 1551 VKDQEEELDE----QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ- 1605

Query: 164  LKSLFEHHKALDEKVRERLRVALERCSL------LEEELGAT--HKELMILKEQNNQKKT 215
             K L +    L+E+  ++ +V  E+  L      L +++       E  + K+    K  
Sbjct: 1606 -KKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKAL 1664

Query: 216  LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDL---------AKVIELQEI---ISKQS 263
            L D  L ++H + + PS          L   E           A  +E++++   I   +
Sbjct: 1665 LADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIA 1724

Query: 264  REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERIT 323
            + ++ ++E+L+ L     E++  L+  ++D+ +  + +          +AQ  D++ ++ 
Sbjct: 1725 KAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLE 1784

Query: 324  TLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQ--- 380
               K     Q +  ++    + LE  + +K  + RQ E K R+L+ RLE    ++++   
Sbjct: 1785 EANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQ-EAKIRELETRLEFERTQVKRLES 1843

Query: 381  -TLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE---KNQELQRARQR 436
               R  E + ++  E  QR+AA ++ +E++  ++ +LR  + ++ E   K  E  R +  
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903

Query: 437  EKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLR-EVESAKKQ-LEETQ 494
             +M+ E            L  +N+ LQ  LK     + D  + +  E+ES + + L  ++
Sbjct: 1904 LEMDLES-----------LEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSE 1952

Query: 495  HDKD 498
             D D
Sbjct: 1953 GDSD 1956



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 86/392 (21%), Positives = 172/392 (43%), Gaps = 52/392 (13%)

Query: 44   LEERDRLLDTLRET-QETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCRE 102
            +E RD  ++  R++ Q+ L   + +L E   ++  + R+    L  + A L+ ++N    
Sbjct: 1590 MESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE-KRELEGKLATLSDQVNRRDF 1648

Query: 103  QLLER-EEEIAELKAERNNTRLLLEHLECLV--SRHERSLRMTVVKRQAQSPAGVSS--- 156
            +  +R  +++   KA   + +L+L+HL+      R    L+  + + +    A V +   
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1708

Query: 157  ---EVEVLKA-LKSLFEHHKALDEKVRERLRVALERCSLLEE------ELGATHKELMI- 205
               E+E L   +  + +   AL+E++    R   E  + LEE      EL   HK  +  
Sbjct: 1709 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1768

Query: 206  --------------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAK 251
                          L+E N +K+ L + +  +  + E    +   +S    +S +E  AK
Sbjct: 1769 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL---VSRQE--AK 1823

Query: 252  VIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSE----EMNTKLQRD 307
            + EL+   ++   E++Q+K RL SL+S + E  E L   R   I +E    E N +LQR 
Sbjct: 1824 IRELE---TRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQ 1879

Query: 308  VREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQL 367
            +R+   +  ++  +     ++    + +  S+   N  L+   A+     ++  D    +
Sbjct: 1880 LRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQ---ADLKLAFKRIGDLQAAI 1936

Query: 368  QERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
            ++ +E  E    + L  +E   +V++EL  RV
Sbjct: 1937 EDEMESDE---NEDLINSEGDSDVDSELEDRV 1965


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 133/626 (21%), Positives = 251/626 (40%), Gaps = 63/626 (10%)

Query: 96   ELNVCREQLLEREEEIAELKA-------ERNNTRLLLEHLECLVSRHERSL---RMTVVK 145
            E+ +  EQ+  ++EEI +L++       ERN  RL  + LE  +S     L   R T   
Sbjct: 1248 EVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGES 1307

Query: 146  RQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVR----ERLRVALERCSLLEEELGATH- 200
                  A  +  +   K +K L   + AL +++     E +   L R + +  E+     
Sbjct: 1308 ASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDA 1367

Query: 201  ------KELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE 254
                  K    ++E +  KK L     D    ++       +R  D     EE    + +
Sbjct: 1368 GGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQ 1427

Query: 255  LQEIISKQSREQSQMKERLASLSSHVTELEE-------DLDTARKDLIKSEEMNTKLQRD 307
            L++   + + E    K  L        ELE+       +L  A ++  + +    KLQR+
Sbjct: 1428 LKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQRE 1487

Query: 308  ----VREAMAQKEDMEER---ITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQT 360
                + EA + K+ +EE+   I    ++ ++ + E   +     K E  +A      R  
Sbjct: 1488 KDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDL 1547

Query: 361  EDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS------KAEERHGNIEE 414
            E K +  +E L+     +Q  L +A+   E+E E  ++  +        + EE   + ++
Sbjct: 1548 EAKVKDQEEELDEQAGTIQM-LEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQK 1606

Query: 415  RLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALE 474
            +L+QME QLEE+ ++ Q+  + ++  E     LSD V++   ES +RL+  LK   A L 
Sbjct: 1607 KLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLA 1666

Query: 475  DKNSLL----------REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHG 524
            D   +L          RE+   K QLEE++      V   +A+  E++ + L+   +   
Sbjct: 1667 DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKA 1726

Query: 525  R----PHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWER 580
            +      L  +   +  + +   +       L +  K  +A    + +++  L  Q  E 
Sbjct: 1727 KTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEA 1786

Query: 581  AQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAIN 640
             ++   L    QA +S  +  +      +L+S         +A    L   L+ +   + 
Sbjct: 1787 NKEKQELQEKLQALQSQVEFLEQSMVDKSLVS-------RQEAKIRELETRLEFERTQVK 1839

Query: 641  KEIRLIQEEKENTEQRAEEIESRVGS 666
            +   L    KEN E+  EE + R+ +
Sbjct: 1840 RLESLASRLKENMEKLTEERDQRIAA 1865



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 127/534 (23%), Positives = 224/534 (41%), Gaps = 81/534 (15%)

Query: 32   ADSHFEQLMVSMLEER-DRLLDTLRETQETLALTQGKLHEV-------------GHERDS 77
            ADS   Q  +  L+++  RL   L++T+  L   Q + HE+              HE   
Sbjct: 1416 ADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQ 1475

Query: 78   LQRQLNTALPQEFAALTKELNVCREQLLEREEEIA-------ELKAERNN---------- 120
             ++     L +E   L  E    ++QL E++ +IA        L+AE  +          
Sbjct: 1476 REKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEA 1535

Query: 121  ----TRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDE 176
                 +  L  LE  V   E  L       Q    A +  E+E+ +  ++  +  ++ DE
Sbjct: 1536 SLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDE 1595

Query: 177  KVRERLRVALERCS----LLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPS 232
            +V E  +   ++       LEEE     K L   +E   +  TL+D V   + E E    
Sbjct: 1596 EVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLR 1655

Query: 233  TSGKRS----SDGSLSHEEDLAKVIELQEIIS-KQSREQSQMKERLASLSSHVTELE-ED 286
               KR+    +D  L  +         +EI   K   E+S+     A  +    E+E ED
Sbjct: 1656 KDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIED 1715

Query: 287  LDTARKDLIKS----EEMNTKLQRDVREAMAQKEDMEERITTLEKRYLA----AQREATS 338
            L     D+ K+    EE  ++LQR+  E   + E+ +E +  L K++ A    A R+   
Sbjct: 1716 LHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQ 1775

Query: 339  VHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQR 398
            ++DL  +LE   ANK+   ++ ++K + LQ ++E  EQ +            V+  L   
Sbjct: 1776 INDLQAQLEE--ANKEK--QELQEKLQALQSQVEFLEQSM------------VDKSL--- 1816

Query: 399  VAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQR-EKMNEEHNKRLSDTVDKLLSE 457
               +S+ E +   +E RL     Q++       R ++  EK+ EE ++R++   +    E
Sbjct: 1817 ---VSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIA--AENREKE 1871

Query: 458  SNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAEL 511
             N+RLQ  L++     E+   L R+   A ++  E + D + L    ++L+A+L
Sbjct: 1872 QNKRLQRQLRD---TKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADL 1922



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 98/488 (20%), Positives = 213/488 (43%), Gaps = 51/488 (10%)

Query: 44   LEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQ 103
            LEE+D  +D    TQ+ ++L + +L ++  +    +  L        A + K+L     +
Sbjct: 1502 LEEKD--MDIAGFTQKVVSL-EAELQDISSQESKDEASL--------AKVKKQLRDLEAK 1550

Query: 104  LLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKA 163
            + ++EEE+ E    +  T  +LE  +  +      +R T  K        V    +  + 
Sbjct: 1551 VKDQEEELDE----QAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQ- 1605

Query: 164  LKSLFEHHKALDEKVRERLRVALERCSL------LEEELGAT--HKELMILKEQNNQKKT 215
             K L +    L+E+  ++ +V  E+  L      L +++       E  + K+    K  
Sbjct: 1606 -KKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKAL 1664

Query: 216  LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDL---------AKVIELQEI---ISKQS 263
            L D  L ++H + + PS          L   E           A  +E++++   I   +
Sbjct: 1665 LADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIA 1724

Query: 264  REQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERIT 323
            + ++ ++E+L+ L     E++  L+  ++D+ +  + +          +AQ  D++ ++ 
Sbjct: 1725 KAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLE 1784

Query: 324  TLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQ--- 380
               K     Q +  ++    + LE  + +K  + RQ E K R+L+ RLE    ++++   
Sbjct: 1785 EANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQ-EAKIRELETRLEFERTQVKRLES 1843

Query: 381  -TLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEE---KNQELQRARQR 436
               R  E + ++  E  QR+AA ++ +E++  ++ +LR  + ++ E   K  E  R +  
Sbjct: 1844 LASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHE 1903

Query: 437  EKMNEEHNKRLSDTVDKLLSESNER---LQLHLKERMAALEDK---NSLLREVESAKKQL 490
             +M+ E  +  + ++   L  + +R   LQ  +++ M + E++   NSL   V   +K+ 
Sbjct: 1904 LEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRK 1963

Query: 491  EETQHDKD 498
             + + D D
Sbjct: 1964 NKLEGDSD 1971



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 91/404 (22%), Positives = 174/404 (43%), Gaps = 61/404 (15%)

Query: 44   LEERDRLLDTLRET-QETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCRE 102
            +E RD  ++  R++ Q+ L   + +L E   ++  + R+    L  + A L+ ++N    
Sbjct: 1590 MESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLRE-KRELEGKLATLSDQVNRRDF 1648

Query: 103  QLLER-EEEIAELKAERNNTRLLLEHLECLV--SRHERSLRMTVVKRQAQSPAGVSS--- 156
            +  +R  +++   KA   + +L+L+HL+      R    L+  + + +    A V +   
Sbjct: 1649 ESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKA 1708

Query: 157  ---EVEVLKA-LKSLFEHHKALDEKVRERLRVALERCSLLEE------ELGATHKELMI- 205
               E+E L   +  + +   AL+E++    R   E  + LEE      EL   HK  +  
Sbjct: 1709 MEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQ 1768

Query: 206  --------------LKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAK 251
                          L+E N +K+ L + +  +  + E    +   +S    +S +E  AK
Sbjct: 1769 ASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSL---VSRQE--AK 1823

Query: 252  VIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSE----EMNTKLQRD 307
            + EL+   ++   E++Q+K RL SL+S + E  E L   R   I +E    E N +LQR 
Sbjct: 1824 IRELE---TRLEFERTQVK-RLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQ 1879

Query: 308  VREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI------------ANKDS 355
            +R+   +  ++  +     ++    + +  S+   N  L+ ++            A +D 
Sbjct: 1880 LRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDE 1939

Query: 356  MHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
            M     D+N  L   L+    K Q+   K E   +V++EL  RV
Sbjct: 1940 ME---SDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRV 1980


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 171/863 (19%), Positives = 336/863 (38%), Gaps = 130/863 (15%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNV 99
            ++ ++E+RDR +++L    + L     KLH                  QE   +TK    
Sbjct: 1786 LLHVIEDRDRKVESLLNEMKEL---DSKLHL-----------------QEVQLMTKI--- 1822

Query: 100  CREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVE 159
              E  +E E+ + ELK E ++    LE+  C    H+  L+      + ++  G++S++E
Sbjct: 1823 --EACIELEKIVGELKKENSDLSEKLEYFSC---DHQELLQ------RVETSEGLNSDLE 1871

Query: 160  V---LKALKSLFEHHKALDEKVRERL--------RVALERCSL------LEEELGATHKE 202
            +     + + + ++   +++  +ER         R+  E+ S+      LE +L     E
Sbjct: 1872 MHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTE 1931

Query: 203  LMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQ 262
             + L++ N  K+ +      +  E+E +  TS +    G L       K   L ++  K 
Sbjct: 1932 KLCLEKDNENKQKVI-----VCLEEELSVVTSERNQLRGELDTMSK--KTTALDQLSEK- 1983

Query: 263  SREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERI 322
                  MKE+   L SH +E    +  A  ++ +  E+   L  DV E +  K  ++E++
Sbjct: 1984 ------MKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL 2037

Query: 323  TTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTL 382
             +LEK       ++ ++     +LEN+IA  +        ++  LQ RL  ++ +     
Sbjct: 2038 QSLEK-------DSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVS 2090

Query: 383  RKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEE 442
            +  E     + E A R   LS  +E    +   + ++  ++E   ++     ++ K  E 
Sbjct: 2091 KALEAALVEKGEFALR---LSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERER 2147

Query: 443  HNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVL 502
             N  L D V+ L  E    LQ+  + +   + D  +   EVE+ K Q+EE         L
Sbjct: 2148 ENDSLKDKVENLERE----LQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFEL 2203

Query: 503  NIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAA 562
            ++  LR+E +++  +             + + +  +++      S  ++L   ++  +  
Sbjct: 2204 DLVTLRSEKENLTKQ-------------IQEKQGQLSELDKLLSSFKSLLEEKEQAEIQI 2250

Query: 563  LRDEPSKVQTLNEQDWERAQQASVLA---NVAQAFESDADVSDGEDDRDTLLSSVDLLSP 619
              +  + V+ L  Q  E  +  + L     + +A E   D    E+ +  L +S++ L  
Sbjct: 2251 KEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQ--LRNSIEKLRA 2308

Query: 620  SGQADAHTLAMMLQE------QLDAINKEIRLIQEEKE--NTEQRAEEIESRVGSGSLDN 671
              +AD      +LQ+        D +   +  ++ E E   T Q    +E+    G ++ 
Sbjct: 2309 RLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVET 2368

Query: 672  LGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRD 731
            L      + I     S         + RS    + +   +E +R+  + ++  S E +  
Sbjct: 2369 L-----KAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQ 2423

Query: 732  DKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQ 791
            +K   K +    SS     L    K       +E +  + N   +      N SS     
Sbjct: 2424 EKEQEKVQMKEKSSTAMEMLQTQLKEL-----NERVAALHNDQEACKAKEQNLSSQVECL 2478

Query: 792  DSLHKAPKKKG----------IKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQD 841
            + L KA   +G          ++SS+  L  + E G+     K+      +S   N  QD
Sbjct: 2479 E-LEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKD----EEISRLKNQIQD 2533

Query: 842  ALGLSKLGGQAEKNRKLQKKHEL 864
               L     Q E   +L K+  L
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNL 2556



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 106/538 (19%), Positives = 216/538 (40%), Gaps = 107/538 (19%)

Query: 31   DADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEF 90
            +AD   +  +   L+ER+R  D+L++  E                 +L+R+L      + 
Sbjct: 2129 EADEKKQLHIAEKLKERERENDSLKDKVE-----------------NLEREL------QM 2165

Query: 91   AALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQS 150
            +   +EL +   +  + E E  + + E     L +  L+ +  R E+      + +Q Q 
Sbjct: 2166 SEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKE----NLTKQIQE 2221

Query: 151  PAGVSSEVE-VLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQ 209
              G  SE++ +L + KSL E  +  + +++E  + A+E                      
Sbjct: 2222 KQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEML-------------------- 2261

Query: 210  NNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIE-LQEIISKQSREQSQ 268
             NQ K L + V  +  +QE   +T  ++S D  +  E  L   IE L+  +    ++Q  
Sbjct: 2262 QNQLKELNEAVAALCGDQEIMKAT--EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLC 2319

Query: 269  MKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKR 328
            + ++L     H   L+  ++   ++L  +         +   +  + E ++ +I  + + 
Sbjct: 2320 VLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQS 2379

Query: 329  YLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETL 388
                + +  ++    + L NE+  +     + E  N   +  L+  EQ+  Q   K+ T 
Sbjct: 2380 LRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTA 2439

Query: 389  PEV----EAELAQRVAALSKAEE----RHGNIEERLRQME---AQL-----EEKN----- 427
             E+      EL +RVAAL   +E    +  N+  ++  +E   AQL     E KN     
Sbjct: 2440 MEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVL 2499

Query: 428  --------QELQRARQREKMNEEHNKRLSDTVD----------------KLLSESN---E 460
                    QE++  +Q+ +  +E   RL + +                 +L  E N    
Sbjct: 2500 QSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELR 2559

Query: 461  RLQLHLKERMAALEDKNSLLREV--------ESAKKQLEETQHDKDQLVLNIEALRAE 510
             L + L++++  L+ KN+ L++         ++ + +LE T+ DK   V  +  + A+
Sbjct: 2560 NLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAK 2617



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 98/525 (18%), Positives = 228/525 (43%), Gaps = 52/525 (9%)

Query: 35   HFEQLMVSMLEERDRLLDTLRETQETLA-LTQGK----LHEVGHERDSLQRQLNTALPQE 89
            H  QL+ + + ++DR    L    E+L  L + K    +    H+R  L      A+   
Sbjct: 737  HKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHS 796

Query: 90   FAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTV-VKRQA 148
            FA +  E         ER E   E      N+ +L   ++ L    E   +M   +++Q 
Sbjct: 797  FANIIGEQGSMPS---ERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQC 853

Query: 149  QSPAGVSSEVE--VLKA-------LKSLFEHHKALDEKVRERLRVALERCSLLEEELGAT 199
            +    +  E+E  ++KA       +    +    L E       V  E  S LE +    
Sbjct: 854  EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK---- 909

Query: 200  HKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIEL-QEI 258
             KEL +L ++   ++     +   NH  E++       S   SL  +E ++ +I L +  
Sbjct: 910  EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKE-MSSIISLNKRE 968

Query: 259  ISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSE----EMNTKLQRDVREAMAQ 314
            I + ++E   +KE  ASL+     L +  ++    + + E    E++ + +++    + +
Sbjct: 969  IEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQR 1028

Query: 315  KEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTED----KNRQLQER 370
             E+       L ++Y AAQ + + +  L ++  +   N+ +   Q ++    ++++   +
Sbjct: 1029 CEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTK 1088

Query: 371  LELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQ-------- 422
            L  AE++ Q  + + ET+   +A  ++     + ++   G +++ +  ++ +        
Sbjct: 1089 LAFAEERNQNLMLELETVQ--QALRSEMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEV 1146

Query: 423  ---LEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNE---RLQLHLKERMAALEDK 476
               L+E  Q ++  + + +     ++ + ++V +  SE N+   + Q+ L+ +  +L+  
Sbjct: 1147 NDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSY 1206

Query: 477  NSLLREVESAKK----QLEETQHDKDQLVLNIEALRAELDHMRLR 517
            N+ L ++E+  +    +L+E++ +K+ L   ++ +R +L+   L+
Sbjct: 1207 NAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQ 1251



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 107/538 (19%), Positives = 218/538 (40%), Gaps = 92/538 (17%)

Query: 32  ADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGH---ERDSLQRQLNTALPQ 88
           A+  F+   +   E R  + +  +E     + ++ K  EV H   E  ++++ LN +  Q
Sbjct: 463 AEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQS--Q 520

Query: 89  EFAALTKELNVCREQLLEREEE-----------------IAELKAERNNTRLLLEHLECL 131
            FA   K  N  +E +L   +E                 +A+L+ +R+ ++ LL+  E  
Sbjct: 521 NFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKRE-- 578

Query: 132 VSRHERSLRMTVVKRQAQSPAGVSS------EVEVLKALKSLFEHHKALDEKVRERLRVA 185
              H   L   + K + +S A +S+      E E LK  K+LF   K+ +EK+  ++   
Sbjct: 579 --HHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESE 636

Query: 186 LERCSLLEEELGATHKELMILKEQNNQK-KTLTDGVLDINHEQENTPSTSGKRSSDGSLS 244
            E        L    K   I   + N++ +TL     +++ E  N  +    +S    + 
Sbjct: 637 KENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKS----VE 692

Query: 245 HEEDLAKVIELQEIIS----KQSREQSQMKERLASLSSHVTELEE----------DLDTA 290
            E      +ELQ+       K  +E   M  + + L+  V +LE           D D  
Sbjct: 693 VETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRC 752

Query: 291 RKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKR---------------------- 328
            +DL    E    L +    ++   ED +  +   +++                      
Sbjct: 753 YQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERS 812

Query: 329 --YLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAE 386
              L A +   +   L +++++   + +S  +   D  +Q +E +++ + ++++ L KAE
Sbjct: 813 ECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQI-KGEIEENLMKAE 871

Query: 387 TLPE-VEAELAQRVAALSKAEERHGNI-----------EERLRQMEAQLEEKNQELQRAR 434
            + +   AE +QR++ L +    H N+           E+ L+ +  ++E +  E+Q  +
Sbjct: 872 QMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELK 931

Query: 435 QREKMNEEHNKR---LSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQ 489
           +   + E+  K    LS+T+     E +  + L+ K  +  L  +N  L+E+ ++  Q
Sbjct: 932 KSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN-KREIEELTQENGTLKEINASLNQ 988



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 124/617 (20%), Positives = 254/617 (41%), Gaps = 91/617 (14%)

Query: 39   LMVSMLEERDRLLDTL----RETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALT 94
            L+   L+E   L +TL    +E    ++L + ++ E+  E  +L +++N +L QE   L 
Sbjct: 936  LLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTL-KEINASLNQEKMNLI 994

Query: 95   KELNVCREQLLEREEEIAELKAERNNTRLLL-------------------------EHLE 129
            ++       + ERE+ I+EL  +    +L+L                           LE
Sbjct: 995  QKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLE 1054

Query: 130  CLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALD---EKVRERLRVAL 186
            CL++           + +    A      E L  L    E ++ L    E V++ LR  +
Sbjct: 1055 CLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEM 1114

Query: 187  -ERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSH 245
             +  +  + E G   +E+M LKE+ N+ +   + +L  N +      T           H
Sbjct: 1115 TDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKT----------KH 1164

Query: 246  EEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQ 305
            E    +   ++  + ++  E++Q   +   +   V E+   LD+    L++ E M    +
Sbjct: 1165 ECQNLESEPIRNSVKERESERNQCNFK-PQMDLEVKEI--SLDSYNAQLVQLEAMLRNKE 1221

Query: 306  RDVREAMAQKEDMEERITT----LEKRYL--AAQREATSVHDLNDKLENEIANKDSMHRQ 359
              ++E+  +KE ++  + T    LE   L     +E + + D     E +  +       
Sbjct: 1222 LKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELST 1281

Query: 360  TEDKNRQLQERLELAEQKLQQ--------TLRKAETLPEVEAELAQRVAALSKAEERHGN 411
            +++ N  LQ  L+    KL +           K E + E+    ++ + A  K  E  G 
Sbjct: 1282 SQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGK 1341

Query: 412  I--EERLRQMEAQL--EEKNQELQRARQREKMNEEHNKRLSDTVD----KLLSESNERLQ 463
            +  E ++   ++ L   E  +++      E+ NE+H   L+   +    + L+ S++ +Q
Sbjct: 1342 LLNEVKILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQ 1401

Query: 464  LH---LKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGAS 520
            +H   L+E+  +L+ ++ +L +      Q  +      +L   +++L+AE     +   +
Sbjct: 1402 MHFAELQEKFLSLQSEHKILHD------QHCQMSSKMSELQTYVDSLKAE---NLVLSTN 1452

Query: 521  LHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWER 580
            L + +  L  V + +  + +G   S S+S V   P    L++L D  S  + L EQ  + 
Sbjct: 1453 LRNFQGDL--VKEMQLGLEEGLVPSLSSSCV---PDSSSLSSLGDS-SFYRALLEQTGD- 1505

Query: 581  AQQASVLANVAQAFESD 597
                S+L+N+  A  ++
Sbjct: 1506 ---MSLLSNLEGAVSAN 1519



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 113/511 (22%), Positives = 219/511 (42%), Gaps = 74/511 (14%)

Query: 40   MVSMLEERDRLLDTLRETQETLALTQ-------GKLHEVGHERDSLQRQLNTALPQEFAA 92
            +V++  E++ L + L++ QE ++  +         L E   E+  ++ + +TA+      
Sbjct: 2387 VVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQ 2446

Query: 93   LTKELNVCREQLLEREEEIAELKAERNNTR---LLLEHLECLVSRHERSLRMTVVKRQAQ 149
            L KELN  R   L  ++E  + K +  +++   L LE  + L    E      V++    
Sbjct: 2447 L-KELNE-RVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQ---S 2501

Query: 150  SPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQ 209
            S  G+  EVE  K      +  +  DE++  RL+  ++    L  +L     E  + KEQ
Sbjct: 2502 SVNGLIQEVEDGK------QKLEKKDEEI-SRLKNQIQDQEQLVSKLSQVEGEHQLWKEQ 2554

Query: 210  NNQKKTLTDGVLDINHEQENTPSTSGK--------RSSDGSLSHEEDLAKVIELQ--EII 259
            N + + LT   +++  + +   S +          +SS  +L +E +L K+ ++   E +
Sbjct: 2555 NLELRNLT---VELEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKV 2611

Query: 260  SKQSREQSQMKERLASLSSHVTELEEDLDTARKDL----------IKSEE--------MN 301
            +K + ++++++  +  ++    EL+E+L   +  L          IKS +         N
Sbjct: 2612 NKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLEN 2671

Query: 302  TKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVH-----DLNDKLENEIAN-KDS 355
            ++L++ +      + + E ++      Y     EA   H     D N + E EI   ++ 
Sbjct: 2672 SELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK 2731

Query: 356  MHRQTEDKNRQ------LQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERH 409
            +  + E  + Q      L+   E     L+ T +  E L + + +  + V  L K  ER 
Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA 2791

Query: 410  GNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKR---LSDTVDKL---LSESNERLQ 463
                + L +   QLEE+ + LQ+   + +  +E  K    +   VD+L   + E  E L+
Sbjct: 2792 QGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLE 2851

Query: 464  LHLKERMAALEDKNSLL---REVESAKKQLE 491
               KE    L+   SLL    ++E AK+ LE
Sbjct: 2852 EKTKEADEYLDKYCSLLISHEKLEKAKEMLE 2882



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 102/496 (20%), Positives = 203/496 (40%), Gaps = 42/496 (8%)

Query: 45  EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQL 104
           ++R   LD+L   +  L   + K+     E  +L+R+ N  L +   +L K       +L
Sbjct: 35  QQRQFQLDSL---EAALQKQKQKVENEKTEGTNLKRE-NQRLMEICESLEKTKQKISHEL 90

Query: 105 LEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQ----SPAGVSSEVEV 160
             +E ++   + + N+ +  +E LE  + R +  L  +    Q+     +P     ++  
Sbjct: 91  QVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFT 150

Query: 161 LKALKSLF---EHHKALDEK----VRERLRVALERCSLLEEELGATHKELMILKEQNNQK 213
                S +     ++ L EK    V ER R+  E  +L  ++   T  +   +  ++  +
Sbjct: 151 TPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQAT-MNHRDIAR 209

Query: 214 KTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERL 273
              +  V   + +QE TPS     S    +  +   +     QE+   +S  Q   ++  
Sbjct: 210 HQASSSVF--SWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDAN 267

Query: 274 ASL--SSHVTELEEDLDTARKDLI-KSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYL 330
           +S   +S    L + L    ++L  K  E+  +LQ   +E   Q    +E    LEK   
Sbjct: 268 SSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEK--- 324

Query: 331 AAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAET--- 387
            A+ E      + +K  +E+    + + Q   K   L+++L+   + L    + AE+   
Sbjct: 325 -AKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARC 383

Query: 388 -----LPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEE 442
                + E E E  +    LS+ +     +++   QM+A+L    QELQ+A+    + + 
Sbjct: 384 SLEQKIKEKEKEFQEE---LSRQQRSFQTLDQECIQMKARL---TQELQQAKNMHNVLQA 437

Query: 443 HNKRLSDTVDKL---LSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQ 499
              +L+    +L   L E  ++L    +   A+   +N L R +E  KK+    +   +Q
Sbjct: 438 ELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQ 497

Query: 500 LVLNIEALRAELDHMR 515
               +  L AEL +++
Sbjct: 498 KAREVCHLEAELKNIK 513



 Score = 58.5 bits (140), Expect = 4e-08
 Identities = 82/405 (20%), Positives = 171/405 (42%), Gaps = 17/405 (4%)

Query: 113 ELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHK 172
           +LKA+    R  +  LE  +  HE+ ++  V K Q        ++VE+++  K L   +K
Sbjct: 282 QLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL---NK 338

Query: 173 ALDEKVRERLRV--ALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENT 230
             DE VR   +   A  + + LE++L    ++L   ++     +   +  +    E+E  
Sbjct: 339 CRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK-EKEKEFQ 397

Query: 231 PSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTA 290
              S ++ S  +L  E    K    QE+  +     + ++  L  L+S   +LE +L+  
Sbjct: 398 EELSRQQRSFQTLDQECIQMKARLTQEL-QQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456

Query: 291 RKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEI 350
           ++ L ++E+     Q    E     E+M++    L+       RE   +      ++  +
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516

Query: 351 ANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELA----QRVAALSKAE 406
               +   + + KN   +  L   ++K+ Q    + TL +++  +A    QR  +    +
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRDLQEKINQQ-ENSLTLEKLKLAVADLEKQRDCSQDLLK 575

Query: 407 ERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHL 466
           +R  +IE+ L    ++ E++++ L  A + +K   E  K    T+       NE+L   +
Sbjct: 576 KREHHIEQ-LNDKLSKTEKESKALLSALELKKKEYEELKE-EKTLFSCWKSENEKLLTQM 633

Query: 467 KERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAEL 511
           +     L+ K   +  +E+  K  +   H+ ++ V  +E  R  L
Sbjct: 634 ESEKENLQSK---INHLETCLKTQQIKSHEYNERVRTLEMDRENL 675



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 63/282 (22%), Positives = 126/282 (44%), Gaps = 36/282 (12%)

Query: 38   QLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKEL 97
            +L   +  E++RL   L+   E +  ++ +L E+  E   L++ L+     +   + KE 
Sbjct: 2634 ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ---VEKEG 2690

Query: 98   NVCREQLLEREEEIAELKAERNNTRLLLE-----------HLECLVSRHE----RSLRMT 142
             V RE++ E +  + E  AE+ +  LLL+           + E L S+ E    + L + 
Sbjct: 2691 KV-REEIAEYQLRLHE--AEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID 2747

Query: 143  VVKRQAQS-PAGVSSEVEVLKALKSL-------FEHHKALDEKVRERLRVALERCSLLEE 194
            ++K   +     + +  ++L+ LK             K  +E+ + ++++ ++ C  LEE
Sbjct: 2748 LLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEE 2807

Query: 195  ELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRS-SDGSLSHEEDLAKVI 253
            E     KEL  L+    ++KT T  V+D   ++  T     K +  + +   +E L K  
Sbjct: 2808 EKEILQKELSQLQAAQEKQKTGT--VMDTKVDELTTEIKELKETLEEKTKEADEYLDKYC 2865

Query: 254  ELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLI 295
             L  +IS +  E++  KE L +  +H+   +   D+    L+
Sbjct: 2866 SL--LISHEKLEKA--KEMLETQVAHLCSQQSKQDSRGSPLL 2903



 Score = 34.7 bits (78), Expect = 0.56
 Identities = 51/244 (20%), Positives = 100/244 (40%), Gaps = 59/244 (24%)

Query: 280 VTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSV 339
           + ELE  LD      +K E+   + Q D  EA  QK+                       
Sbjct: 20  IQELEGQLDK-----LKKEKQQRQFQLDSLEAALQKQ----------------------- 51

Query: 340 HDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRV 399
                K+ENE     ++ R+ + +  ++ E LE  +QK+   L+  E+  +V  +  Q  
Sbjct: 52  ---KQKVENEKTEGTNLKRENQ-RLMEICESLEKTKQKISHELQVKES--QVNFQEGQ-- 103

Query: 400 AALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESN 459
             L+  +++   +E+ L++ +++LE   Q  Q A        + +    +T  K+ +   
Sbjct: 104 --LNSGKKQIEKLEQELKRCKSELERSQQAAQSA--------DVSLNPCNTPQKIFTTPL 153

Query: 460 ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
              Q +   +   L++K +  +EVE  K+           L   ++AL+A+     L  A
Sbjct: 154 TPSQYYSGSKYEDLKEKYN--KEVEERKR-----------LEAEVKALQAKKASQTLPQA 200

Query: 520 SLHH 523
           +++H
Sbjct: 201 TMNH 204


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 95.5 bits (236), Expect = 3e-19
 Identities = 142/656 (21%), Positives = 268/656 (40%), Gaps = 76/656 (11%)

Query: 43   MLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ------EFAALTKE 96
            +LE++ +L   + E Q  L L       +  ER+ ++  L     Q      E + L + 
Sbjct: 612  LLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQR 671

Query: 97   LNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSS 156
            L     +L +  EE+ ++K ER   +  +  L+  +S     L         +  A +  
Sbjct: 672  LEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEE 731

Query: 157  EVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQ-NNQKKT 215
             ++  + L+ L    +  ++ +R+R R        L+EE+ +  +E+  LKEQ + + + 
Sbjct: 732  LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQA 791

Query: 216  LTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLAS 275
            L + V +     E   S S     D + +      +V  LQE   K      +++ R+A 
Sbjct: 792  LRESVEEATKNVEVLASRSNTSEQDQAGTE----MRVKLLQEENEKLQGRSEELERRVAQ 847

Query: 276  LSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQRE 335
            L   + +L+ D   A++ L K E    +L+  +  A  ++++       LE    AAQ  
Sbjct: 848  LQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGN 907

Query: 336  ATSV----HDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAE--QKLQQTLRKAETLP 389
             +        L++KL+ E   K+ + R    KN    ER  L +  +KLQ+     E   
Sbjct: 908  LSQTTQEQKQLSEKLKEESEQKEQLRRL---KNEMENERWHLGKTIEKLQK-----EMAD 959

Query: 390  EVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRAR--------QREKMNE 441
             VEA     +   ++ +E        L +M+ QL+EK  E +++R        +   M E
Sbjct: 960  IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019

Query: 442  E--HNKRLSD---TVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQ----LEE 492
            E    +R  D   T  +LL ++ + L+  L+ +    +D++ L++++E    Q    LEE
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079

Query: 493  TQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVL 552
             +++ D L   I   R +++ +R               +   R    D   D  S    L
Sbjct: 1080 ERNNSDLLSERISRSREQMEQLR-------------NELLQERAARQDLECDKIS----L 1122

Query: 553  RRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLS 612
             R  K       D  S++  L E  +  +++  V+   A+  E +  +   E DR  L  
Sbjct: 1123 ERQNK-------DLKSRIIHL-EGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQL 1174

Query: 613  SVDLLSPSGQA------DAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIES 662
            S   L    +       D H   + L +Q D ++  ++ ++ + E  E+  + +ES
Sbjct: 1175 SNRRLERKVKELVMQVDDEH---LSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLES 1227



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 116/536 (21%), Positives = 238/536 (44%), Gaps = 99/536 (18%)

Query: 48   DRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLER 107
            + LL   ++ Q+ L + + +  ++  +R+     L  AL +E ++  +E++  +EQ    
Sbjct: 730  EELLQAKQDLQDLL-IAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQY--- 785

Query: 108  EEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSL 167
                AEL+A R +     +++E L SR   S          Q  AG    V++L+     
Sbjct: 786  ---DAELQALRESVEEATKNVEVLASRSNTS---------EQDQAGTEMRVKLLQ----- 828

Query: 168  FEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQ 227
             E ++ L  +  E  R   +    +E+  G   K    LK+   + + L + ++    E+
Sbjct: 829  -EENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEE 887

Query: 228  ENTPSTSGKRSSDGSLSHEE-DLAKVIELQEIISKQSREQSQMKERLASLSS-------H 279
            +   + S +R+ +  L   + +L++  + Q+ +S++ +E+S+ KE+L  L +       H
Sbjct: 888  KE--AVSARRALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWH 945

Query: 280  VTELEEDLDTARKDLIKSEEMNT-------------------KLQRDVREAMAQKED--- 317
            + +  E L     D++++   +T                   ++QR ++E   + E    
Sbjct: 946  LGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRL 1005

Query: 318  ----MEERITTLEKR---YLAAQREATS--------VHDLNDKLENEIANKDSMHR---Q 359
                M++ +  +E+    Y  AQ EA +        + DL  +LE +   KD   R   Q
Sbjct: 1006 TAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQ 1065

Query: 360  TEDKNRQLQERLELAEQKLQQTL------RKAETLPEVEAELAQRVAALSKAEERHGNIE 413
             EDK  QL+  +EL E++    L      R  E + ++  EL Q  AA    E    ++E
Sbjct: 1066 MEDKVSQLE--MELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLE 1123

Query: 414  ERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSE---------SNERLQL 464
             + + +++++       + ++  E +  +   R+++  D+L SE         SN RL+ 
Sbjct: 1124 RQNKDLKSRIIHLEGSYRSSK--EGLVVQMEARIAELEDRLESEERDRANLQLSNRRLER 1181

Query: 465  HLKERMAALED--------KNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELD 512
             +KE +  ++D        K+ L   +++ K+Q+EE + + D+L  + + L+ EL+
Sbjct: 1182 KVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 132/623 (21%), Positives = 256/623 (41%), Gaps = 101/623 (16%)

Query: 104  LLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLR----------MTVVKRQAQSPAG 153
            LL+ ++E+ +   E    ++L  +L+   + ++ + +           T+  R A S  G
Sbjct: 539  LLKGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQG 598

Query: 154  VSSEVEVLKALKSLFEHHKALDEKVRE---RLRVALERCSLLEEELGATHKELMILKEQN 210
             +        +K L E    L  +V E   +L++ ++    ++EE       L  L+ Q+
Sbjct: 599  NNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQH 658

Query: 211  NQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHE-EDLAKVIELQEIISKQSREQSQM 269
            N+K             +EN+        S+G L    E+L +V        K  REQ Q 
Sbjct: 659  NEKV------------EENSTLQQRLEESEGELRKNLEELFQV--------KMEREQHQT 698

Query: 270  KERLASLSSHVTELEEDLDTARK--DLIKSEEMNTKLQ--RDVREAMAQKEDMEERITTL 325
            + R   L   ++E+ ++LD+A++  D  K   +   LQ  +D+++ +  KE+ E+ +   
Sbjct: 699  EIR--DLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKR 756

Query: 326  EKRYLA---AQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTL 382
            E+   A   A +E  S HD            D +  Q + + + L+E +E A + ++   
Sbjct: 757  ERELTALKGALKEEVSSHD---------QEMDKLKEQYDAELQALRESVEEATKNVEVLA 807

Query: 383  RKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEE 442
             ++ T  + +A    RV  L +  E+       L+    +LE +  +LQR  +  K +E 
Sbjct: 808  SRSNTSEQDQAGTEMRVKLLQEENEK-------LQGRSEELERRVAQLQRQIEDLKGDEA 860

Query: 443  HNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVL 502
              K      +  + +  E L    KE   A+  + +L  E+E+A+  L +T  ++ QL  
Sbjct: 861  KAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQEQKQLSE 920

Query: 503  NIEALRAELDHMRLRGASLHHGRPHLG-SVPDFRFPMAD-------------GHTDSYST 548
             ++    + + +R     + + R HLG ++   +  MAD                D Y  
Sbjct: 921  KLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKE 980

Query: 549  S-----AVLRR--------PQKGRLAALR-DEPSKVQTLNEQDWERAQ-----QASVLAN 589
                  A ++R         +K RL A++  +  ++     +D++RAQ     +  +L  
Sbjct: 981  KNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQ 1040

Query: 590  VAQAFESDADV-SDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQE 648
              +  E + +  S  +DDR  L+  +       +     L M L+E+ +  +     I  
Sbjct: 1041 TLKDLEYELEAKSHLKDDRSRLVKQM-------EDKVSQLEMELEEERNNSDLLSERISR 1093

Query: 649  EKENTEQ-RAEEIESRVGSGSLD 670
             +E  EQ R E ++ R     L+
Sbjct: 1094 SREQMEQLRNELLQERAARQDLE 1116



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 100/456 (21%), Positives = 180/456 (39%), Gaps = 95/456 (20%)

Query: 37   EQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKE 96
            E+ +V   +E    +   R  +  L   QG L +   E    Q+QL+  L +E       
Sbjct: 877  EEALVHARKEEKEAVSARRALENELEAAQGNLSQTTQE----QKQLSEKLKEES------ 926

Query: 97   LNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSS 156
                     E++E++  LK E  N R    HL   + + ++ +   +V+    S   + +
Sbjct: 927  ---------EQKEQLRRLKNEMENERW---HLGKTIEKLQKEMA-DIVEASRTSTLELQN 973

Query: 157  EVEVLKAL--KSLFEHHKALDEKVRERLRVAL------ERCSLLEEELGATHKELMILKE 208
            +++  K    + L E  + L EK  E  +  L      +   L+EEEL    ++    ++
Sbjct: 974  QLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEEL----RDYQRAQD 1029

Query: 209  QNNQKKTLTDGVL-DINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS 267
            +   K+ L +  L D+ +E E        RS             V ++++ +S+   E  
Sbjct: 1030 EALTKRQLLEQTLKDLEYELEAKSHLKDDRSR-----------LVKQMEDKVSQLEMELE 1078

Query: 268  QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEK 327
            + +     LS  ++   E ++  R +L++       L+ D      Q +D++ RI  LE 
Sbjct: 1079 EERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEG 1138

Query: 328  RY------LAAQREATSVHDLNDKLENEI---ANKDSMHRQTEDKNRQL-----QERLEL 373
             Y      L  Q EA  + +L D+LE+E    AN    +R+ E K ++L      E L L
Sbjct: 1139 SYRSSKEGLVVQMEAR-IAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSL 1197

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRA 433
             +QK Q +LR                                L+ M+ Q+EE  +E+ R 
Sbjct: 1198 TDQKDQLSLR--------------------------------LKAMKRQVEEAEEEIDRL 1225

Query: 434  RQREKMNEEHNKRLSDTVDKLLSESNE-RLQLHLKE 468
               +K  +   +   D  + L  + N  +  L LK+
Sbjct: 1226 ESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLKK 1261


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 183/858 (21%), Positives = 349/858 (40%), Gaps = 170/858 (19%)

Query: 65   QGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLL 124
            Q KL E   +R  L+      L ++    T+E +  +E L  R+ E  +   E  N + L
Sbjct: 372  QRKLDEEVKKRQKLEPS-QVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRL 430

Query: 125  LEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDE-------- 176
            L+  E L  RH    ++  ++ + +   G     EVL  LK L E  + L+E        
Sbjct: 431  LDQGEDL--RHGLETQVMELQNKLKHVQGPEPAKEVL--LKDLLETRELLEEVLEGKQRV 486

Query: 177  ----KVRERLRVALERCSLLEEELGATHKELMILKEQNNQ-----KKTLTDGVLD----- 222
                ++RER   AL+    L+EE+ +  +E+  +++Q  +     ++++ D   D     
Sbjct: 487  EEQLRLRERELTALK--GALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLE 544

Query: 223  ------------INHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMK 270
                        +  E E T   +G   S    + E+  A   EL ++  ++   + ++ 
Sbjct: 545  AERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELG 604

Query: 271  ERLASLSSHVTELEEDL-DTARKDLIKSEEMNTKLQRDVREAMAQKEDME----ERITTL 325
            E++  L   + +      DT + +++K E + T  Q +++E  A+++  E     R   L
Sbjct: 605  EKIEVLQRELEQARASAGDTRQVEVLKKELLRT--QEELKELQAERQSQEVAGRHRDREL 662

Query: 326  EKRYLAAQREATSVHDLND------------KLENEIANKDSMH---------------- 357
            EK+    + EA    +L +            + + E A+K  M                 
Sbjct: 663  EKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVE 722

Query: 358  ---RQTEDKNRQLQERLELAEQKLQQT-----------LRKAETLPEVEAELAQRVAALS 403
               R+T+++N + + R+   EQ+L++T            R  + L  +EAE  Q   AL+
Sbjct: 723  TTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALN 782

Query: 404  KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQ 463
             ++E  G++    R +EA+LEE  + L R  Q ++           T+++ L E  ++ +
Sbjct: 783  ASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQ-----------TLNRALEEEGKQRE 831

Query: 464  LHLKERMAALEDKNSLL-REVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLH 522
            + L+   A LE++  LL R V+   K+LE+   D  Q    ++ L+A+L+  + +     
Sbjct: 832  V-LRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQA---LQQLQAQLEDYKEKARR-- 885

Query: 523  HGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKV-QTLNEQDWER- 580
                    V D +    D  +++  TS        G L+ L+DE  ++ Q L     ER 
Sbjct: 886  -------EVADAQRQAKDWASEAEKTS--------GGLSRLQDEIQRLRQALQASQAERD 930

Query: 581  --AQQASVLANVAQAFESDAD-VSDGEDDRDTLL----SSVDLLSPSGQADAHTLAMML- 632
                   +LA   Q  E +A+     +DDR   L      V  L      + +T+ ++  
Sbjct: 931  TARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVELLTD 990

Query: 633  -----QEQLDAINKEIRLIQE---------EKENTEQRAEEIESRVGSGS-----LDNLG 673
                 ++Q+D +  E  L+QE         +K + E++ +++++R+ S         +L 
Sbjct: 991  RVNRGRDQVDQLRTE--LMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLS 1048

Query: 674  RFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDK 733
            +  S + +        A        +ST R++     R+V  L +   +   R+ V D K
Sbjct: 1049 QLESQNQL--LQERLQAEEREKTVLQSTNRKL----ERKVKELSIQ--IEDERQHVNDQK 1100

Query: 734  TTIKCETS------PPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSS 787
              +             +     RLD L K A   V  E+  ++     ++   +   S  
Sbjct: 1101 DQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV--EEQHEVNEQLQARIKSLEKDSWR 1158

Query: 788  NSSQDSLHKAPKKKGIKS 805
             +S+ +   A K +G+ S
Sbjct: 1159 KASRSAAESALKNEGLSS 1176



 Score = 68.9 bits (167), Expect = 3e-11
 Identities = 122/580 (21%), Positives = 228/580 (39%), Gaps = 79/580 (13%)

Query: 150 SPAGVSSEVEVLKALKSLFEHHKALDEKVRERLR-----VALER--------CSLLEE-- 194
           S   V+ + E+ + ++ L    + LDE+V++R +     V LER        CS L+E  
Sbjct: 354 STKAVAGQGELTRKVEEL---QRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELL 410

Query: 195 -----ELGATHKELMILKEQNNQKKTLTDGV-LDINHEQENTPSTSGKRSSDGSLSHEED 248
                E   ++KEL  +K   +Q + L  G+   +   Q       G   +   L   +D
Sbjct: 411 ERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLL--KD 468

Query: 249 LAKVIE-LQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRD 307
           L +  E L+E++  + R + Q++ R   L++    L+E++ +  +++   E +  + QRD
Sbjct: 469 LLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEV---EHVRQQYQRD 525

Query: 308 VREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLE---NEIANKDSMHR------ 358
             +     +D  +    LE      Q+ +  V  L  +LE    E  +  SM +      
Sbjct: 526 TEQLRRSMQDATQDHAVLEAE---RQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDL 582

Query: 359 ------------QTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEA---ELAQRVAALS 403
                       + E+   +L E++E+ +++L+Q    A    +VE    EL +    L 
Sbjct: 583 RATKQELLQLRMEKEEMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642

Query: 404 KAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQ 463
           + +    + E   R  + +LE++   L+    R +  EE N +L  T+ +L  +  E   
Sbjct: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEA-- 700

Query: 464 LHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMR-------L 516
              K +M A  +   L +   + +  L ETQ + D+    I  L  +L   R        
Sbjct: 701 --SKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGGEA 758

Query: 517 RGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKV----QT 572
             A L      L +         +   +   + A  +R  + RL   +   +++    QT
Sbjct: 759 VEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQQT 818

Query: 573 LNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMML 632
           LN    E  +Q  VL       E    + D   DR  L   ++ +    +     L   L
Sbjct: 819 LNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDR--LNKELEKIGEDSKQALQQLQAQL 876

Query: 633 QEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNL 672
           ++  +   +E+   Q + ++    AE+      SG L  L
Sbjct: 877 EDYKEKARREVADAQRQAKDWASEAEKT-----SGGLSRL 911



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 108/474 (22%), Positives = 205/474 (43%), Gaps = 60/474 (12%)

Query: 45   EERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQL 104
            E R R+L   ++ +ET  L  G        RD LQR     L  E   L + LN  +E+ 
Sbjct: 734  EFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQR-----LEAEKQQLEEALNASQEE- 787

Query: 105  LEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPA--GVSSEVEVLK 162
               E  +A  K            LE  +   +R L     ++Q  + A      + EVL+
Sbjct: 788  ---EGSLAAAK----------RALEARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLR 834

Query: 163  ALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELM--ILKEQNNQKKTLTDGV 220
              K+  E  K L ++  +RL   LE+       +G   K+ +  +  +  + K+     V
Sbjct: 835  RGKAELEEQKRLLDRTVDRLNKELEK-------IGEDSKQALQQLQAQLEDYKEKARREV 887

Query: 221  LDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHV 280
             D   + ++  S + K S  G LS  +D     E+Q +  +Q+ + SQ +   A      
Sbjct: 888  ADAQRQAKDWASEAEKTS--GGLSRLQD-----EIQRL--RQALQASQAERDTA------ 932

Query: 281  TELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVH 340
              L+++L   R   ++ E  N K  +D R    Q + +EE+++ LE        E  +V 
Sbjct: 933  -RLDKELLAQRLQGLEQEAENKKRSQDDR--ARQLKGLEEKVSRLETE---LDEEKNTVE 986

Query: 341  DLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVA 400
             L D++       D +  +   + R  ++ LE  +  L++  +  +T         +  A
Sbjct: 987  LLTDRVNRGRDQVDQLRTELM-QERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSA 1045

Query: 401  ALSKAEERHGNIEERLRQMEAQ---LEEKNQELQR-ARQREKMNEEHNKRLSDTVDKLLS 456
            +LS+ E ++  ++ERL+  E +   L+  N++L+R  ++     E+  + ++D  D+ LS
Sbjct: 1046 SLSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQ-LS 1104

Query: 457  ESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAE 510
               + L+  + E    +E  + L ++   A++++EE     +QL   I++L  +
Sbjct: 1105 LRVKALKRQVDEAEEEIERLDGLRKK---AQREVEEQHEVNEQLQARIKSLEKD 1155



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 92/451 (20%), Positives = 169/451 (37%), Gaps = 37/451 (8%)

Query: 238 SSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKS 297
           SS+   S    ++ V+E  + +   S   ++       L+  V EL+  LD   K   K 
Sbjct: 326 SSESETSVRRKVSLVLEKMQPLVMVSSGSTKAVAGQGELTRKVEELQRKLDEEVKKRQKL 385

Query: 298 EEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLND------------- 344
           E     L+R + E   +   ++E +   +     + +E  ++  L D             
Sbjct: 386 EPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQV 445

Query: 345 -KLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAAL- 402
            +L+N++ +        E   + L E  EL E+ L+   R  E L   E EL     AL 
Sbjct: 446 MELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALK 505

Query: 403 SKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKL---LSESN 459
            +   R   +E   +Q +   E+  + +Q A Q   + E   +++S  V  L   L E++
Sbjct: 506 EEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETS 565

Query: 460 ERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGA 519
           E             ED  +  +E+   + + EE +   ++L   IE L+ EL+  R    
Sbjct: 566 EETGHWQSMFQKNKEDLRATKQELLQLRMEKEEME---EELGEKIEVLQRELEQARASAG 622

Query: 520 SLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLR---RPQKGRLAALRDEPSKVQTLNEQ 576
                      +   +  + +   +  S     R   R  + +LA LR E  + + L EQ
Sbjct: 623 DTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQ 682

Query: 577 DWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQL 636
           +    Q    L  + Q  E  +      +   T+L          +A   T     QE+ 
Sbjct: 683 N---LQLQKTLQQLRQDCEEASKAKMVAEAEATVLG-------QRRAAVETTLRETQEEN 732

Query: 637 DAINKEIRLIQEEKENTE---QRAEEIESRV 664
           D   + I  ++++ + T       E +E+R+
Sbjct: 733 DEFRRRILGLEQQLKETRGLVDGGEAVEARL 763


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 94.0 bits (232), Expect = 8e-19
 Identities = 146/730 (20%), Positives = 293/730 (40%), Gaps = 118/730 (16%)

Query: 11  EAEGPPGGGGGHGSGSPSQPDADS------HFEQLMVSMLEER------DRLLDTLRETQ 58
           EA    G   GHG  S      D         + L  S+ EE+       + L+  +  Q
Sbjct: 61  EAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQ 120

Query: 59  ETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAER 118
           +  A   G + +   E  SL++QL  A  + F  + +  ++  ++  +   EIA++K++ 
Sbjct: 121 QQEAKPDGLVTDSSAELQSLEQQLEEAQTENFN-IKQMKDLFEQKAAQLATEIADIKSKY 179

Query: 119 NNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKV 178
           +  R L E  E  V+R    L               + E  V++ LK+       +++  
Sbjct: 180 DEERSLREAAEQKVTRLTEEL---------------NKEATVIQDLKTELLQRPGIED-- 222

Query: 179 RERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGV-LDINHEQENTPSTSGKR 237
                                   + +LK++  Q +TL D + L+   E E       K 
Sbjct: 223 ------------------------VAVLKKELVQVQTLMDNMTLERERESEKLKDECKKL 258

Query: 238 SSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKS 297
            S  + S     A + +L+  ++K  +E +   + L  L S V EL +   T  ++L+K 
Sbjct: 259 QSQYASSE----ATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKK 314

Query: 298 EEMNTKLQRDVREAMAQKEDMEERI-------TTLEKRYLAAQREATSVH-------DLN 343
           E+  TKL+    E    K++++  +         L+ R  A++     +H       +  
Sbjct: 315 EQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEAT 374

Query: 344 DKLENEIANKDSMHRQTEDKNRQLQERLELAEQ---KLQQTLRKAET-LPEVEAELAQRV 399
            KL+ E++  ++ ++  + + +QLQ++ E  EQ   +LQ  + +  + L E E +L +  
Sbjct: 375 QKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAH 434

Query: 400 AALSKA-----------EERHGNIEERLRQMEAQLEEK---NQELQRARQREKMNEEHNK 445
             L +            E++  +++ +L ++E QL+EK   + ELQ    + K   +  +
Sbjct: 435 GRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQ 494

Query: 446 RLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVES----AKKQLEETQHDKDQLV 501
            L  +    L E+   L+  L++    + DK+  ++ +E+    +K+ +   + +++ L 
Sbjct: 495 ALQQSTTAKLREAQNDLEQVLRQ----IGDKDQKIQNLEALLQKSKENISLLEKEREDLY 550

Query: 502 LNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLA 561
             I+A   E   +       H  +  +  + +     ++ H  +        + QK  L 
Sbjct: 551 AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR 610

Query: 562 ALRDEPSKVQT----LNEQDWERAQQAS------------VLANVAQAFESDADVSDGED 605
           A +D    ++T    LN Q  E  ++ S            +L+  A      AD+ +  D
Sbjct: 611 AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLD 670

Query: 606 DRDTLLSSV--DLLSPSGQADAHTLAMM-LQEQLDAINKEIRLIQEEKENTEQRAEEIES 662
                L     +L   + Q D  T  +   QE    +   ++  +E+  + EQ+ EE+E 
Sbjct: 671 TAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEG 730

Query: 663 RVGSGSLDNL 672
           ++     D+L
Sbjct: 731 QIKKLEADSL 740



 Score = 89.7 bits (221), Expect = 1e-17
 Identities = 146/689 (21%), Positives = 289/689 (41%), Gaps = 74/689 (10%)

Query: 37   EQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKE 96
            EQ +  +  +  RL + L+E        Q +L     ++   Q Q   AL Q   A  +E
Sbjct: 452  EQQVADLQLKLSRLEEQLKEKVTNSTELQHQL-----DKTKQQHQEQQALQQSTTAKLRE 506

Query: 97   LNVCREQLL----EREEEIAELKA----ERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 148
                 EQ+L    +++++I  L+A     + N  LL +  E L ++ +     T V  Q 
Sbjct: 507  AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQL 566

Query: 149  QSPAGVSSE--VEVLKALKSLFEHHKALDEKVRER-------LRVALERCSLLEEELGAT 199
            Q       E   ++ + LK+  E HK   E + ++       LR A +R   LE  +   
Sbjct: 567  QEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNEL 626

Query: 200  HKELMILKEQNNQK----KTLTDGVLDI------------NHEQENTPSTSGKRSSDGSL 243
            + +L   KE+ +Q     K  T+ +L              NH      +   K+     +
Sbjct: 627  NSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKI 686

Query: 244  SHEED--LAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMN 301
            + + D   AK+ + QE  S+      + KE+  SL     ELE  +     D ++ +   
Sbjct: 687  TTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASK 746

Query: 302  TKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVH--DLNDKLENEIANKDSMHRQ 359
             +  +D+++      D+E R T L K+ L  ++E  S    DL  K E   + K  + +Q
Sbjct: 747  EQALQDLQQQRQLNTDLELRATELSKQ-LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQ 805

Query: 360  TEDKN------RQLQERLELAEQKLQQTLRKAET-LPEVEAELAQRVAALSKAEERHGNI 412
             E+K         L +  ++  ++L   ++   T L +V+ E    +  LS  +++   +
Sbjct: 806  EEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKV 865

Query: 413  EERLRQMEAQLEEKNQELQRA-RQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMA 471
             + L+  +++ E++NQ+ + A    EK  +E   +L   ++  L E  E  +   KE+ A
Sbjct: 866  SDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEA 925

Query: 472  ALEDK---NSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHL 528
            + + K   NS+  ++  A+  L++ + ++ QL  NI  L+   +  + +  +L  G   +
Sbjct: 926  SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEAL-QGELKI 984

Query: 529  GSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQ---DWERAQQAS 585
              +   +  + +      + +A     +K +++ L++   K Q   +Q   D+   +++ 
Sbjct: 985  AVLQ--KTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDF-YGRESE 1041

Query: 586  VLANVAQAFESDADVSDGEDD----------RDTLLSSVDLLSPSGQADAHTLAMMLQEQ 635
            +LA        +  +S  ++D          ++ L+  +     + + D+      LQE+
Sbjct: 1042 LLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQER 1101

Query: 636  ---LDAINKEIRLIQEEKENTEQRAEEIE 661
               L  I KE  L ++E  N + +  EIE
Sbjct: 1102 CKALQDIQKEKSLKEKELVNEKSKLAEIE 1130



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 135/666 (20%), Positives = 264/666 (39%), Gaps = 127/666 (19%)

Query: 31   DADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSL------------ 78
            D   H  QL   + E +++ L   ++T+E     +G++ ++  E DSL            
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEEL----EGQIKKL--EADSLEVKASKEQALQD 752

Query: 79   ---QRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRH 135
               QRQLNT L      L+K+L        E E+EI       ++TRL L+      S  
Sbjct: 753  LQQQRQLNTDLELRATELSKQL--------EMEKEIV------SSTRLDLQKK----SEA 794

Query: 136  ERSLRMTVVKRQAQSPAGVSSEVEVLKA-LKSLFEHHKALDEKVRERLRVALERCSLLEE 194
              S++  + K++         E ++LK   ++L +  K   E++  R++  +     ++ 
Sbjct: 795  LESIKQKLTKQE--------EEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKM 846

Query: 195  ELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVI- 253
            E  A   EL           T+ D +  ++   +N+ S   K +  G  +   DL K   
Sbjct: 847  EKEALMTEL----------STVKDKLSKVSDSLKNSKSEFEKENQKGKAAIL-DLEKTCK 895

Query: 254  ----ELQEIISKQSREQSQMKERLA-------SLSSHVTELEEDLDTARKDLIKSEEMNT 302
                +LQ  +    +EQ ++K+ L         L   +  ++E L  A+  L ++E+   
Sbjct: 896  ELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQ 955

Query: 303  KLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTED 362
            +LQ ++ E     E  +++I  L+     A  + T   +L +KL+ ++          ++
Sbjct: 956  QLQGNINELKQSSEQKKKQIEALQGELKIAVLQKT---ELENKLQQQLTQAAQELAAEKE 1012

Query: 363  KNRQLQERLELAEQKLQQTLRKAET-LPEVEAELAQRVAALSKAEERHGNIEERLRQMEA 421
            K   LQ   E    K Q+T ++ ++     E+EL      L   EE+    +E L     
Sbjct: 1013 KISVLQNNYE----KSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRN 1068

Query: 422  QLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALED--KNSL 479
            Q+  +N+ +Q  +               T    L + + + +  L+ER  AL+D  K   
Sbjct: 1069 QIGNQNKLIQELK---------------TAKATLEQDSAKKEQQLQERCKALQDIQKEKS 1113

Query: 480  LREVE--SAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFP 537
            L+E E  + K +L E +  K +    I  L  EL   +L           + ++ D +  
Sbjct: 1114 LKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIK------EITNLKDAKQL 1167

Query: 538  MADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESD 597
            +     +    +  L+       AA+  E    Q L +Q  +  ++        +  E +
Sbjct: 1168 LIQQKLELQGKADSLK-------AAVEQEKRNQQILKDQVKKEEEELK-----KEFIEKE 1215

Query: 598  ADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRA 657
            A +     +++            G          L  Q+ A+N+ +  +++E +++++R 
Sbjct: 1216 AKLHSEIKEKEV-----------GMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRV 1264

Query: 658  EEIESR 663
             E+E +
Sbjct: 1265 SELEKQ 1270



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 89/476 (18%), Positives = 203/476 (42%), Gaps = 64/476 (13%)

Query: 29   QPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQ 88
            + +A    +  + SM E+  +  +TL++ ++     QG ++E+    +  ++Q+     +
Sbjct: 922  EKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGE 981

Query: 89   EFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQA 148
               A+ ++  +  +   +  +   EL AE+       E +  L + +E+S          
Sbjct: 982  LKIAVLQKTELENKLQQQLTQAAQELAAEK-------EKISVLQNNYEKS---------- 1024

Query: 149  QSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKE 208
                      E  K L+S F   ++     R+ L+   E+ SL +E+L +   ++     
Sbjct: 1025 ---------QETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQI----- 1070

Query: 209  QNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQ 268
              NQ K +           +   +       D +   ++   +   LQ+I     +E+S 
Sbjct: 1071 -GNQNKLI-----------QELKTAKATLEQDSAKKEQQLQERCKALQDI----QKEKSL 1114

Query: 269  MKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKR 328
             ++ L +  S + E+EE      K++ K   +N +L+    E++ +  ++++    L ++
Sbjct: 1115 KEKELVNEKSKLAEIEEIKCRQEKEITK---LNEELKSHKLESIKEITNLKDAKQLLIQQ 1171

Query: 329  YLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAET- 387
             L  Q +A S   L   +E E  N+  +  Q + +  +L++     E KL   +++ E  
Sbjct: 1172 KLELQGKADS---LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVG 1228

Query: 388  ---LPEVEAELAQRVAALSK----AEERHGNIEERLRQMEAQLEEKNQELQRARQREKMN 440
                 E EA+L  ++ AL++     ++   + + R+ ++E Q ++   E+       + N
Sbjct: 1229 MKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNN 1288

Query: 441  EEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREV--ESAKKQLEETQ 494
            ++  + L +   K   E  E+LQ  + E    L++  + ++E+  E+   Q++ TQ
Sbjct: 1289 QDERRALLERCLKGEGEI-EKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 88/418 (21%), Positives = 179/418 (42%), Gaps = 57/418 (13%)

Query: 48   DRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLN---TALPQEFAALTKELNVCREQL 104
            + L  +  + ++ +   QG+L     ++  L+ +L    T   QE AA  ++++V +   
Sbjct: 962  NELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNY 1021

Query: 105  LEREEEIAELKAE--RNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLK 162
             + +E   +L+++     + LL    +      + SL    +          +  ++ LK
Sbjct: 1022 EKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELK 1081

Query: 163  ALKSLFEHHKALDEKVRERLRVALERCSLLEE---ELGATHKELMILKEQNNQKKTLTDG 219
              K+  E   A  E+  +      ERC  L++   E     KEL+      N+K  L + 
Sbjct: 1082 TAKATLEQDSAKKEQQLQ------ERCKALQDIQKEKSLKEKELV------NEKSKLAE- 1128

Query: 220  VLDINHEQE------NTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQS------ 267
            + +I   QE      N    S K  S   +++ +D AK + +Q+ +  Q +  S      
Sbjct: 1129 IEEIKCRQEKEITKLNEELKSHKLESIKEITNLKD-AKQLLIQQKLELQGKADSLKAAVE 1187

Query: 268  QMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVRE---AMAQKEDMEERIT- 323
            Q K     L   V + EE+L   +K+ I+ E    KL  +++E    M + E+ E ++T 
Sbjct: 1188 QEKRNQQILKDQVKKEEEEL---KKEFIEKE---AKLHSEIKEKEVGMKKHEENEAKLTM 1241

Query: 324  ----------TLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLEL 373
                      T++K + ++QR  + +    D L  EIA  ++  +  +D+ R L ER   
Sbjct: 1242 QITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLK 1301

Query: 374  AEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQ 431
             E ++++   K   + E++ +L    AA+ +    + +++ +  Q   +   ++ E+Q
Sbjct: 1302 GEGEIEKLQTK---VLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.128    0.352 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,311,232
Number of Sequences: 37866
Number of extensions: 2184625
Number of successful extensions: 25963
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 435
Number of HSP's successfully gapped in prelim test: 1289
Number of HSP's that attempted gapping in prelim test: 11962
Number of HSP's gapped (non-prelim): 6936
length of query: 1202
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1088
effective length of database: 13,930,794
effective search space: 15156703872
effective search space used: 15156703872
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.