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Search of human proteins with 4505507
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505507 oligophrenin 1 [Homo sapiens]
(802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505507 oligophrenin 1 [Homo sapiens] 1624 0.0
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 752 0.0
gi|208022687 GTPase regulator associated with the focal adhesion... 649 0.0
gi|7662208 GTPase regulator associated with the focal adhesion k... 648 0.0
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 628 e-180
gi|188497642 ARHGAP15 [Homo sapiens] 127 3e-29
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 123 8e-28
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 123 8e-28
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 119 1e-26
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 119 1e-26
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 112 1e-24
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 112 1e-24
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 112 1e-24
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 112 2e-24
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 110 4e-24
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 110 7e-24
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 107 4e-23
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 106 7e-23
gi|54860105 nadrin isoform 2 [Homo sapiens] 104 3e-22
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 102 1e-21
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 102 1e-21
gi|54860079 nadrin isoform 1 [Homo sapiens] 100 7e-21
gi|91208437 GEM interacting protein [Homo sapiens] 99 2e-20
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens] 99 2e-20
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 97 6e-20
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 97 6e-20
gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens] 95 3e-19
gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a... 94 5e-19
gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b... 94 5e-19
gi|23510413 sorting nexin 26 [Homo sapiens] 94 7e-19
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 1624 bits (4206), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF
Sbjct: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
Query: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR
Sbjct: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
Query: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD
Sbjct: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
Query: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS
Sbjct: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
Query: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300
STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM
Sbjct: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300
Query: 301 TPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWM 360
TPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWM
Sbjct: 301 TPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLWM 360
Query: 361 EAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKL 420
EAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKL
Sbjct: 361 EAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKL 420
Query: 421 LNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDY 480
LNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDY
Sbjct: 421 LNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDY 480
Query: 481 RLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTV 540
RLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTV
Sbjct: 481 RLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTV 540
Query: 541 AAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERT 600
AAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERT
Sbjct: 541 AAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERT 600
Query: 601 VFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG 660
VFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG
Sbjct: 601 VFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG 660
Query: 661 KLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEG 720
KLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEG
Sbjct: 661 KLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPRPLAHHKEG 720
Query: 721 DADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRT 780
DADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRT
Sbjct: 721 DADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIVAGNAGEITSSVVASRT 780
Query: 781 RFFETASRKTGSSQGRLPGDES 802
RFFETASRKTGSSQGRLPGDES
Sbjct: 781 RFFETASRKTGSSQGRLPGDES 802
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 752 bits (1942), Expect = 0.0
Identities = 407/750 (54%), Positives = 507/750 (67%), Gaps = 41/750 (5%)
Query: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
MG P LEFSD YLDSPDFRERL+C+E ELERTNKFIK++IKDG+ LI A+RN S AVQKF
Sbjct: 1 MGLPTLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKF 60
Query: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
SQ+LQ FQF+ IGD TDDEI+IA+S KEFA LL VE ER ++ NA+D+LI PLE FR
Sbjct: 61 SQSLQDFQFECIGDAETDDEISIAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFR 120
Query: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
KEQIG K+ KKKF+K+ E++YS+L++HL+LS+KKKES LQEAD Q+D+E NF+E+SL+
Sbjct: 121 KEQIGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLE 180
Query: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
YV++IQEVQE KKF VEP+L+FL LF EL Q+F PYKQQLQ +LQNTRN+F
Sbjct: 181 YVFKIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFE 240
Query: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300
STR+E+E L +RMK A Q + P Q T+EGYLY QEK LG +W+K+YC Y+K +KT TM
Sbjct: 241 STRQEVERLMQRMKSANQDYRPPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKGSKTFTM 300
Query: 301 TPMEQKPGAK------QGPLDLTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEA 354
+ E K K P LK C+RRKT+SIDKRFCFDIE ER G ITLQA SEA
Sbjct: 301 SVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITLQAFSEA 360
Query: 355 NRRLWMEAMDGKEPIYHSP--ITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVG 412
NR+LW+EAMDGKEPIY P I+K++EM LNE GF FVRKCI +ET+GI GLYR G
Sbjct: 361 NRKLWLEAMDGKEPIYTLPAIISKKEEMYLNEAGFNFVRKCIQAVETRGITILGLYRIGG 420
Query: 413 SNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSA 472
N +VQKL+N F PK P D+D WD KTITS LK YLR L+EP+MTY+LHK+ + A
Sbjct: 421 VNSKVQKLMNTTFSPKSPPDIDIDIELWDNKTITSGLKNYLRCLAEPLMTYKLHKDFIIA 480
Query: 473 AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTL 532
KSD+ +YR+ A+H+LV+KLPEKNREML++LI+HLV V HS++NLMT SN+GVIFGPTL
Sbjct: 481 VKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHLVKVSLHSQQNLMTVSNLGVIFGPTL 540
Query: 533 MRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITIS 592
MRAQE+TVAAMMNIKFQNIVVEILIEH+ KI+ P+ S P P R +RR + I +S
Sbjct: 541 MRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTAPDPSIPLPQPQSRSGSRRTRAICLS 600
Query: 593 KRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQRSGETDPGRKS 652
+ R YT L E + + +P+ T SIE + +S P KS
Sbjct: 601 TGSRKPRG-RYTPCLAEPDSDSYSSSPDSTPMGSIESLSSHSSEQNSTTKSASCQPREKS 659
Query: 653 PSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAPR 712
P + TP ++NG T +P + A +
Sbjct: 660 GGIPWI-------------------------ATPSSSNGQKSLGLWTTSPESSSREDATK 694
Query: 713 PLAHHKEGDADSFSKVRPPGEKPTIIRPPV 742
A E D S + V PG+ + PP+
Sbjct: 695 TDA---ESDCQSVASVTSPGD----VSPPI 717
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 649 bits (1674), Expect = 0.0
Identities = 354/714 (49%), Positives = 472/714 (66%), Gaps = 24/714 (3%)
Query: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
MG P LEFSDC LDSP FRE LK +E EL++TNKFIK++IKDG +LISA++N SSA +KF
Sbjct: 1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60
Query: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
+ +L F+F IGD TDDE+ IA S +EFA +L +E+ER+ M+ NAS++LI PLE FR
Sbjct: 61 ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120
Query: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
KEQIG KE KKK++K+ E++ +L++HL+LSSKKKESQLQEAD QVD R +F+E SL+
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180
Query: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
YV+++QEVQE K F VEP+LAFL LF EL +DF +K QL +S+QNTRN F
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240
Query: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300
TR E+E L K+MKE P K T+EGYLY QEK G SWVK+YC Y++++K +TM
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITM 300
Query: 301 TPMEQKPGAKQGPLD-LTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLW 359
P +QK G K G + + LK C RRKT+SI+KRFCFD+E +RPG IT+QALSE +RRLW
Sbjct: 301 VPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLW 360
Query: 360 MEAMDGKEPIYHSPITKQQE--MELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQV 417
MEAMDG+EP+Y+S Q E +L+ +GF +RKCI+ +ET+GI +GLYR VG N +V
Sbjct: 361 MEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRV 420
Query: 418 QKLLNAFFDPKCPGDVDFH-NSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSD 476
QKLL+ DPK + + ++W+IKTITS+LK YLR L P+M Y+ + + AAK +
Sbjct: 421 QKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLE 480
Query: 477 NLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ 536
N + R+ IHSLV++LPEKNR+ML+LL+ HL NV + K+NLMT +N+GV+FGPTL+R Q
Sbjct: 481 NQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQ 540
Query: 537 EDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAA-PPVPPPRVTARRHKPITISKRL 595
E+TVAA+M+IKFQNIV+EILIE+ KI+ P+ + R + KP + S+R
Sbjct: 541 EETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERP 600
Query: 596 LRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKL-------PIQRSGETDP 648
L T+F+T E +++ N I SS+E + L P S + D
Sbjct: 601 L---TLFHTVQSTEKQEQ-----RNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDL 652
Query: 649 GRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTP 702
P+RP L P P L +P T+ S P TP
Sbjct: 653 AVVKPTRP---NSLPPNPS-PTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVSTP 702
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 648 bits (1671), Expect = 0.0
Identities = 345/676 (51%), Positives = 465/676 (68%), Gaps = 22/676 (3%)
Query: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
MG P LEFSDC LDSP FRE LK +E EL++TNKFIK++IKDG +LISA++N SSA +KF
Sbjct: 1 MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF 60
Query: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
+ +L F+F IGD TDDE+ IA S +EFA +L +E+ER+ M+ NAS++LI PLE FR
Sbjct: 61 ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR 120
Query: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
KEQIG KE KKK++K+ E++ +L++HL+LSSKKKESQLQEAD QVD R +F+E SL+
Sbjct: 121 KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE 180
Query: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
YV+++QEVQE K F VEP+LAFL LF EL +DF +K QL +S+QNTRN F
Sbjct: 181 YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE 240
Query: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCQYEKETKTLTM 300
TR E+E L K+MKE P K T+EGYLY QEK G SWVK+YC Y++++K +TM
Sbjct: 241 GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITM 300
Query: 301 TPMEQKPGAKQGPLD-LTLKYCVRRKTESIDKRFCFDIETNERPGTITLQALSEANRRLW 359
P +QK G K G + + LK C RRKT+SI+KRFCFD+E +RPG IT+QALSE +RRLW
Sbjct: 301 VPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLW 360
Query: 360 MEAMDGKEPIYHSPITKQQE--MELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQV 417
MEAMDG+EP+Y+S Q E +L+ +GF +RKCI+ +ET+GI +GLYR VG N +V
Sbjct: 361 MEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRV 420
Query: 418 QKLLNAFFDPKCPGDVDFH-NSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSD 476
QKLL+ DPK + + ++W+IKTITS+LK YLR L P+M Y+ + + AAK +
Sbjct: 421 QKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLE 480
Query: 477 NLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ 536
N + R+ IHSLV++LPEKNR+ML+LL+ HL NV + K+NLMT +N+GV+FGPTL+R Q
Sbjct: 481 NQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQ 540
Query: 537 EDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEESAA-PPVPPPRVTARRHKPITISKRL 595
E+TVAA+M+IKFQNIV+EILIE+ KI+ P+ + R + KP + S+R
Sbjct: 541 EETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERP 600
Query: 596 LRERTVFYT----------SSLDESEDEIQHQTPNGTI--TSSIEPPKPPQHPKLPIQRS 643
L T+F+T +S+ S E PN + +SS++P P L + +
Sbjct: 601 L---TLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKP 657
Query: 644 GETD--PGRKSPSRPI 657
+ P SP+ P+
Sbjct: 658 TRPNSLPPNPSPTSPL 673
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 628 bits (1619), Expect = e-180
Identities = 363/821 (44%), Positives = 503/821 (61%), Gaps = 70/821 (8%)
Query: 1 MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGNALISAMRNYSSAVQKF 60
MG PLEFSDCYLDSP FRER++ +E ELERTNKFIK++IKDG LI+A ++ S A +KF
Sbjct: 1 MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKF 60
Query: 61 SQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLENFR 120
+ +L+ F+F+FIGD +TDDE I S +EF+ L +E +R +M + ++ LIKPLE FR
Sbjct: 61 AHSLRDFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFR 120
Query: 121 KEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESSLD 180
KEQ+G KE KKKF+K+ E+ YSL+D+HL+LS+KKK+S LQEAD+QV++ R +F+E SL+
Sbjct: 121 KEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLE 180
Query: 181 YVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFS 240
YV ++QE+QE KKF VEP+L+F +F EL +DF YK +LQ+++QNTRN F
Sbjct: 181 YVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE 240
Query: 241 STREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEK--WALGISWVKYYCQYEKETKTL 298
TR E+EEL ++++ P+ K Q T EGYLY QEK G SWVK+YC Y K K
Sbjct: 241 GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKF 300
Query: 299 TMTPMEQKPGAKQGPLDL-TLKYCVRRKTESIDKRFCFDIETNERPG-TITLQALSEANR 356
M P E + G K G ++ LK C +R T+SID+RFCFDIE +RPG ++T+QA SE R
Sbjct: 301 NMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEER 360
Query: 357 RLWMEAMDGKEPIYHSPIT-----KQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTV 411
+ W+EA+ GKE + HS T + +L+++GF +RKCI+ +ET+GI +GLYR V
Sbjct: 361 KQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLYRVV 420
Query: 412 GSNIQVQKLLNAFFDPKCPGDVDFHNS-DWDIKTITSSLKFYLRNLSEPVMTYRLHKELV 470
G + +VQ+LL+ D K +VD NS DW++KTITS+LK YLR+L EP+MTY LH + +
Sbjct: 421 GVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI 480
Query: 471 SAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGP 530
AKS + + R+ AIH LV+KLPEKN+EML++L++HL NV HSK+NLMT +N+GV+FGP
Sbjct: 481 VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGP 540
Query: 531 TLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEE--------SAAPPVPPPRVT 582
TLMR QE+TVAA+M++KFQNIVVEILIE+ KI+ PP+ SA+PP PPR +
Sbjct: 541 TLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQS 600
Query: 583 ARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSSIEPPKPPQHPKLPIQR 642
R+ +R R V Y L+ + + + + T TSS++ P +
Sbjct: 601 KRQ------GQRTKRPVAV-YNLCLELEDGDNPYPSKEDTPTSSLDSLSSPSPVTTAV-- 651
Query: 643 SGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTP 702
PG P + L L DGG + G + P +T
Sbjct: 652 -----PGPPGPDKNHL------------------LADGG-------SFGDWASTIPGQTR 681
Query: 703 SFHIKRPAPRPLAHHKEGDADSFSKVRP--PGEKPTIIRPPVRPPDPPCRAATPQKPEPK 760
S ++ P+ S S V P PG P PP D P + +K
Sbjct: 682 SSMVQWLNPQ-----SPTTTSSNSAVTPLSPGSSPFPFSPPATVADKPPESIRSRKARAV 736
Query: 761 PDIVAGNAGEITSSVVASRTRFFE--TASRKTGSSQGRLPG 799
A ++ E++ + A FE SR+ G +G L G
Sbjct: 737 YPCEAEHSSELSFEIGA----IFEDVQTSREPGWLEGTLNG 773
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 127 bits (320), Expect = 3e-29
Identities = 66/200 (33%), Positives = 118/200 (59%), Gaps = 5/200 (2%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
K+ I+ S + K E E + V + FV++CI +E +G+ +G+YR G+ +QKL F
Sbjct: 275 KDQIFGSHLHKVCERENSTVPW-FVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLR---F 330
Query: 426 DPKCPGDVDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGA 484
++ +S W DI +T +LK + R L EP+ Y ++ V A K + + R+ A
Sbjct: 331 IVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEA 390
Query: 485 IHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM 544
+ SLV KLP NR+ +++L HL + + +NLM+ ++G++FGPTL+RA+ +T +
Sbjct: 391 VKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAI 450
Query: 545 NIKFQNIVVEILIEHFGKIY 564
++ +QN + E+++ + KI+
Sbjct: 451 HMVYQNQIAELMLSEYSKIF 470
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 123 bits (308), Expect = 8e-28
Identities = 67/168 (39%), Positives = 100/168 (59%), Gaps = 2/168 (1%)
Query: 393 CINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFY 452
CI IE +G+K+EGLYR G ++ + AF D+ N DI IT +LK Y
Sbjct: 297 CIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISA-NVYPDINIITGALKLY 355
Query: 453 LRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCE 512
R+L PV+TY + + + AAK N D RL A+H ++ LP + E L L+ HL V
Sbjct: 356 FRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTM 415
Query: 513 HSKENLMTPSNMGVIFGPTLMRAQED-TVAAMMNIKFQNIVVEILIEH 559
+ K+N M N+G++FGPTLMR ED T+ + ++++Q ++V+ILIE+
Sbjct: 416 NEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIEN 463
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 123 bits (308), Expect = 8e-28
Identities = 67/168 (39%), Positives = 100/168 (59%), Gaps = 2/168 (1%)
Query: 393 CINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFY 452
CI IE +G+K+EGLYR G ++ + AF D+ N DI IT +LK Y
Sbjct: 161 CIREIEARGLKSEGLYRVSGFTEHIEDVKMAFDRDGEKADISA-NVYPDINIITGALKLY 219
Query: 453 LRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCE 512
R+L PV+TY + + + AAK N D RL A+H ++ LP + E L L+ HL V
Sbjct: 220 FRDLPIPVITYDTYSKFIDAAKISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTM 279
Query: 513 HSKENLMTPSNMGVIFGPTLMRAQED-TVAAMMNIKFQNIVVEILIEH 559
+ K+N M N+G++FGPTLMR ED T+ + ++++Q ++V+ILIE+
Sbjct: 280 NEKDNFMNAENLGIVFGPTLMRPPEDSTLTTLHDMRYQKLIVQILIEN 327
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 119 bits (298), Expect = 1e-26
Identities = 66/171 (38%), Positives = 104/171 (60%), Gaps = 2/171 (1%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
V CI IE++G+ +EGLYR G + ++ + AF D+ + + DI IT +L
Sbjct: 285 VDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE-DINIITGAL 343
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVN 509
K Y R+L P++TY + + + +AK + D +L +H + LP + E L L+ HL
Sbjct: 344 KLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKR 403
Query: 510 VCEHSKENLMTPSNMGVIFGPTLMRAQE-DTVAAMMNIKFQNIVVEILIEH 559
V H KENLM N+G++FGPTLMR+ E D +AA+ +I++Q +VVE+LI++
Sbjct: 404 VTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN 454
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 119 bits (298), Expect = 1e-26
Identities = 66/171 (38%), Positives = 104/171 (60%), Gaps = 2/171 (1%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
V CI IE++G+ +EGLYR G + ++ + AF D+ + + DI IT +L
Sbjct: 259 VDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYE-DINIITGAL 317
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVN 509
K Y R+L P++TY + + + +AK + D +L +H + LP + E L L+ HL
Sbjct: 318 KLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKR 377
Query: 510 VCEHSKENLMTPSNMGVIFGPTLMRAQE-DTVAAMMNIKFQNIVVEILIEH 559
V H KENLM N+G++FGPTLMR+ E D +AA+ +I++Q +VVE+LI++
Sbjct: 378 VTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKN 428
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 112 bits (281), Expect = 1e-24
Identities = 64/201 (31%), Positives = 116/201 (57%), Gaps = 8/201 (3%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAF- 424
K+ ++ S + + E V KFV+ CI +E G+ +G+YR G+ +QKL A
Sbjct: 650 KDQVFGSNLANLCQRENGTVP-KFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVN 708
Query: 425 FDPKCPGDVDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLG 483
D K +D ++S W DI IT +LK + R L EP+ T+ + V+A K + R+
Sbjct: 709 HDEK----LDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQ-RVA 763
Query: 484 AIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAM 543
A+ L+ +LP+ N++ +++L RHL V E+ ++N MT ++ ++FGPTL++ +++T
Sbjct: 764 AVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIA 823
Query: 544 MNIKFQNIVVEILIEHFGKIY 564
++ +QN +VE+++ I+
Sbjct: 824 VHTVYQNQIVELILLELSSIF 844
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 112 bits (280), Expect = 1e-24
Identities = 62/204 (30%), Positives = 110/204 (53%), Gaps = 7/204 (3%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
K+ ++ + E E + V +FV++CI +E +G+ +GLYR G+ +QKL +
Sbjct: 323 KDQVFGCALAALCERERSRVP-RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---Y 378
Query: 426 DPKCPGDVDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGA 484
+D + W D+ IT +LK + R L EP+ + ++ ++A K + R
Sbjct: 379 KVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRC 438
Query: 485 IHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM 544
+ LV LP N + L +L +HL V EH ++N M+ ++ ++FGPTL+R + + + M
Sbjct: 439 VRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM 498
Query: 545 NIKFQNIVVEILIEHFGKIYLGPP 568
+ FQN VVE++++ I+ PP
Sbjct: 499 TMVFQNQVVELILQQCADIF--PP 520
Score = 31.2 bits (69), Expect = 4.0
Identities = 31/142 (21%), Positives = 55/142 (38%), Gaps = 19/142 (13%)
Query: 648 PGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTP---SF 704
PG RP P PE D + ++ + +P + G + P TP S
Sbjct: 7 PGSPGDPRP-------PTPETDYPESLTSYPE--EDYSPVGSFGEPGPTSPLTTPPGWSC 57
Query: 705 HIKRPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPPCRAATPQKPEPKPDIV 764
H+ + +H F++ + P P I + D P +A+ P++ P
Sbjct: 58 HVSQDKQMLYTNH-------FTQEQVPVPAPRSIHKSSQDGDTPAQASPPEEKVPAELDE 110
Query: 765 AGNAGEITSSVVASRTRFFETA 786
G+ E++ + A RT+ + A
Sbjct: 111 VGSWEEVSPATAAVRTKTLDKA 132
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 112 bits (280), Expect = 1e-24
Identities = 62/204 (30%), Positives = 110/204 (53%), Gaps = 7/204 (3%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
K+ ++ + E E + V +FV++CI +E +G+ +GLYR G+ +QKL +
Sbjct: 350 KDQVFGCALAALCERERSRVP-RFVQQCIRAVEARGLDIDGLYRISGNLATIQKLR---Y 405
Query: 426 DPKCPGDVDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGA 484
+D + W D+ IT +LK + R L EP+ + ++ ++A K + R
Sbjct: 406 KVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRC 465
Query: 485 IHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM 544
+ LV LP N + L +L +HL V EH ++N M+ ++ ++FGPTL+R + + + M
Sbjct: 466 VRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEETSMPM 525
Query: 545 NIKFQNIVVEILIEHFGKIYLGPP 568
+ FQN VVE++++ I+ PP
Sbjct: 526 TMVFQNQVVELILQQCADIF--PP 547
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 112 bits (279), Expect = 2e-24
Identities = 70/259 (27%), Positives = 121/259 (46%), Gaps = 28/259 (10%)
Query: 389 FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSS 448
F+ +CI IE G+ TEG+YR G+ +++ L F ++D D+ + T+ +
Sbjct: 1264 FIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDH---NLDLAEKDFTVNTVAGA 1320
Query: 449 LKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLV 508
+K + L +P++ Y + +LV A K ++ + +L A+ ++ K P++N E+ + +I HL
Sbjct: 1321 MKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLN 1380
Query: 509 NVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPP 568
V ++K NLMT N+ + F PTLMR T+ A+ + ++E+ I+ + P
Sbjct: 1381 KVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRP 1440
Query: 569 --EESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTITSS 626
E A P P V + TV + +S + Q+P T
Sbjct: 1441 ITEPPGARPSSPSAVAS----------------TVPFLTSTPVTSQPSPPQSPPPT---- 1480
Query: 627 IEPPKPPQHPKLPIQRSGE 645
P+ P P LP Q E
Sbjct: 1481 ---PQSPMQPLLPSQLQAE 1496
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 110 bits (276), Expect = 4e-24
Identities = 73/209 (34%), Positives = 115/209 (55%), Gaps = 32/209 (15%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
V+KC+ IE + ++T+G+YR G +V+KL AF + K ++ S DI + L
Sbjct: 778 VKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELS-QASPHDISNV---L 833
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRL-----------------------GAIH 486
K YLR L EP++++RL+ ELV AK D+L G +
Sbjct: 834 KLYLRQLPEPLISFRLYHELVGLAK-DSLKAEAEAKAASRGRQDGSESEAVAVALAGRLR 892
Query: 487 SLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ--EDTV--AA 542
L+ LP +NR L+ L+RHL + E ++N MTP N+G++FGPTL+R + E TV ++
Sbjct: 893 ELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSS 952
Query: 543 MMNIKFQNIVVEILIEHFGKIYLGPPEES 571
+++ Q V+E LI H+G ++ PEE+
Sbjct: 953 LVDYPHQARVIETLIVHYGLVFEEEPEET 981
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 110 bits (274), Expect = 7e-24
Identities = 62/206 (30%), Positives = 108/206 (52%), Gaps = 10/206 (4%)
Query: 373 PITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGD 432
P T+ Q + L V C I+E +G+++ G+YR G+N V L + PGD
Sbjct: 818 PATENQRVPL------IVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQL--NRGPGD 869
Query: 433 VDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYK 491
++ + W D+ I+S LK + R L EP+ T + + + A + ++ R+ + L+
Sbjct: 870 INLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRD 929
Query: 492 LPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM-NIKFQN 550
LP E L+ L+ HL + +HS++N M P N+ ++FGPTL+R ED + M+ ++ +
Sbjct: 930 LPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRY 989
Query: 551 IVVEILIEHFGKIYLGPPEESAAPPV 576
+VE LI+H + ++ PV
Sbjct: 990 KIVETLIQHSDWFFSDEEDKGERTPV 1015
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 107 bits (267), Expect = 4e-23
Identities = 98/385 (25%), Positives = 169/385 (43%), Gaps = 56/385 (14%)
Query: 6 LEFSDCYLDSPDFRERLKCYEQE-------LERTNKFIKDVIKDGNALISAMRNYSSAVQ 58
+EF +C DSP FR + E + L++ K +++ G A +S R + S V+
Sbjct: 3 VEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVR 62
Query: 59 KFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPLEN 118
SQ Q GDT+ I+E + FA+ L EV N M++ A + + L++
Sbjct: 63 DLSQQCQ-------GDTV------ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQS 109
Query: 119 FRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLQEADLQVDKERHNFFESS 178
F KE + KE KK+F+K E L R+ + + + +++EA + R F +
Sbjct: 110 FVKEDVRKFKETKKQFDKVREDLELSLVRNAQ-APRHRPHEVEEATGALTLTRKCFRHLA 168
Query: 179 LDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNH 238
LDYV QI +Q KKF I++ +L+F+H+ L PY ++L L
Sbjct: 169 LDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVID 228
Query: 239 FSSTREEMEELKKRMKE-------------APQTCKLPGQPTIEGYLYTQEKWALGISWV 285
+ + EME +++ P +EGYL+ + A +W
Sbjct: 229 SAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFK-TWN 287
Query: 286 KYYCQ-------YEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTESIDKRFCFDIE 338
+ + Y+K+ K ++ L+ C + E I++RFCF++
Sbjct: 288 RRWFSIQNSQLVYQKKLKDALTVVVDD------------LRLCSVKPCEDIERRFCFEVL 335
Query: 339 TNERPGTITLQALSEANRRLWMEAM 363
+ + + LQA SE R+ W++A+
Sbjct: 336 SPTK--SCMLQADSEKLRQAWVQAV 358
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 106 bits (265), Expect = 7e-23
Identities = 64/187 (34%), Positives = 102/187 (54%), Gaps = 9/187 (4%)
Query: 393 CINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDW-DIKTITSSLKF 451
C ++E +G++ G+YR G+N + + K D+D + W D+ I+S LK
Sbjct: 1168 CCKLVEERGLEYTGIYRVPGNNAAISSMQEEL--NKGMADIDIQDDKWRDLNVISSLLKS 1225
Query: 452 YLRNLSEPVMTYRLHKELVSA-AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNV 510
+ R L EP+ T + + + A K D LD RL + L++ LPE + E L+ L HL V
Sbjct: 1226 FFRKLPEPLFTNDKYADFIEANRKEDPLD-RLKTLKRLIHDLPEHHYETLKFLSAHLKTV 1284
Query: 511 CEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM-NIKFQNIVVEILIEHFGKIYLGPPE 569
E+S++N M P N+ ++FGPTL+R ED + M+ ++ Q +VE LI+H + E
Sbjct: 1285 AENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFF---TE 1341
Query: 570 ESAAPPV 576
E A P+
Sbjct: 1342 EGAEEPL 1348
>gi|54860105 nadrin isoform 2 [Homo sapiens]
Length = 803
Score = 104 bits (260), Expect = 3e-22
Identities = 101/398 (25%), Positives = 166/398 (41%), Gaps = 58/398 (14%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
++P + +P+ + + E+ + C+ ++ G+K EGL+R +G+ K L A
Sbjct: 246 EKPAFGTPLEEHLKRSGREIALP-IEACVMLLLETGMKEEGLFR-IGAGASKLKKLKAAL 303
Query: 426 DPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAI 485
D +F++ D + +LK YLR L EP+MT+ L++E A + D +L +
Sbjct: 304 DCSTSHLDEFYS---DPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360
Query: 486 HSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ-EDTVAAMM 544
KLP +N LI+ L + + S N MTPSN+ ++ GP L+ A+ E T+A M
Sbjct: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
Query: 545 NIKFQNI--VVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVF 602
++ V+E +I+H + E + + P + H F
Sbjct: 421 AATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHS--------------F 466
Query: 603 YTSSLDESEDEIQHQTP------NGTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRP 656
+T + D ++ + P G + PPK PK P+ + PGR +
Sbjct: 467 HTGN-DSDSGTLERKRPASMAVMEGDLVKKESPPK----PKDPVS-AAVPAPGRNNSQ-- 518
Query: 657 ILDGKLEPCPEVDVGKLVSRLQDGGTKITPKATNGPMPGSGPTKTPSFHIKRPAP----- 711
I G+ +P +L + P GP P T +K+PAP
Sbjct: 519 IASGQNQPQAAAGSHQL--------SMGQPHNAAGPSP-----HTLRRAVKKPAPAPPKP 565
Query: 712 -RPLAHHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPP 748
P H G + S + PP P +PP R P PP
Sbjct: 566 GNPPPGHPGGQSSSGTSQHPPSLSP---KPPTRSPSPP 600
Score = 33.1 bits (74), Expect = 1.0
Identities = 37/146 (25%), Positives = 54/146 (36%), Gaps = 31/146 (21%)
Query: 626 SIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKIT 685
S+ P P + P P Q +G+ PG+ PS P +S + + ++
Sbjct: 587 SLSPKPPTRSPSPPTQHTGQ-PPGQ--PSAP---------------SQLSAPRRYSSSLS 628
Query: 686 P-KATNGPMPGSGPTKTPSFHIK---RPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPP 741
P +A N P P TP H K + P P+A E + S P + P
Sbjct: 629 PIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPP--------QTP 680
Query: 742 VRPPDPPCRAATPQKPEPKPDIVAGN 767
P PP P P P+ + GN
Sbjct: 681 TPPSTPPLGKQNPSLPAPQ-TLAGGN 705
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 102 bits (255), Expect = 1e-21
Identities = 56/192 (29%), Positives = 100/192 (52%), Gaps = 16/192 (8%)
Query: 389 FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLL------------NAFFDPKCPGD---V 433
F+R CI ++ +G+ +G+YR G+ VQKL + P+ PG +
Sbjct: 539 FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRL 598
Query: 434 DFHNSDWD-IKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKL 492
D +++WD I +T +LK +LR L +P++ L +A + L I L+ +
Sbjct: 599 DLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSM 658
Query: 493 PEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIV 552
P+ N + L L+ HL V HS +N MTP N+G++FGPTL R +++T + + +
Sbjct: 659 PKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQL 718
Query: 553 VEILIEHFGKIY 564
V++++ +F ++
Sbjct: 719 VQLMLTNFTSLF 730
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 102 bits (255), Expect = 1e-21
Identities = 56/192 (29%), Positives = 100/192 (52%), Gaps = 16/192 (8%)
Query: 389 FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLL------------NAFFDPKCPGD---V 433
F+R CI ++ +G+ +G+YR G+ VQKL + P+ PG +
Sbjct: 355 FLRLCIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRL 414
Query: 434 DFHNSDWD-IKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKL 492
D +++WD I +T +LK +LR L +P++ L +A + L I L+ +
Sbjct: 415 DLDSTEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSM 474
Query: 493 PEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIV 552
P+ N + L L+ HL V HS +N MTP N+G++FGPTL R +++T + + +
Sbjct: 475 PKPNHDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQL 534
Query: 553 VEILIEHFGKIY 564
V++++ +F ++
Sbjct: 535 VQLMLTNFTSLF 546
>gi|54860079 nadrin isoform 1 [Homo sapiens]
Length = 881
Score = 100 bits (248), Expect = 7e-21
Identities = 117/453 (25%), Positives = 186/453 (41%), Gaps = 90/453 (19%)
Query: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
++P + +P+ + + E+ + C+ ++ G+K EGL+R +G+ K L A
Sbjct: 246 EKPAFGTPLEEHLKRSGREIALP-IEACVMLLLETGMKEEGLFR-IGAGASKLKKLKAAL 303
Query: 426 DPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAI 485
D +F++ D + +LK YLR L EP+MT+ L++E A + D +L +
Sbjct: 304 DCSTSHLDEFYS---DPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDL 360
Query: 486 HSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQ-EDTVAAMM 544
KLP +N LI+ L + + S N MTPSN+ ++ GP L+ A+ E T+A M
Sbjct: 361 WRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMA 420
Query: 545 NIKFQNI--VVEILIEHFGKIYLGPPEE------SAAPPVPPPRV-------------TA 583
++ V+E +I+H + PEE A P+ P T
Sbjct: 421 AATSVHVVAVIEPIIQHADWFF---PEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTL 477
Query: 584 RRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGT-----ITSSIEPPKPPQH--- 635
R +P +++ + E + S + Q GT I+ + +PP PP
Sbjct: 478 ERKRPASMA---VMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGST 534
Query: 636 -----PKLPIQRS-------GET------------DPGRKSPSRPILD-GKLEPCPEVDV 670
P+ P Q S G T PG SP +P P P
Sbjct: 535 VVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAP---- 590
Query: 671 GKLVSRLQDGGTKITPKATNG--------PMPGSGPT-KTPSFHIKRPAP------RPLA 715
G+ S++ G + P+A G P +GP+ T +K+PAP P
Sbjct: 591 GRNNSQIASGQNQ--PQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPP 648
Query: 716 HHKEGDADSFSKVRPPGEKPTIIRPPVRPPDPP 748
H G + S + PP P +PP R P PP
Sbjct: 649 GHPGGQSSSGTSQHPPSLSP---KPPTRSPSPP 678
Score = 33.1 bits (74), Expect = 1.0
Identities = 37/146 (25%), Positives = 54/146 (36%), Gaps = 31/146 (21%)
Query: 626 SIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEVDVGKLVSRLQDGGTKIT 685
S+ P P + P P Q +G+ PG+ PS P +S + + ++
Sbjct: 665 SLSPKPPTRSPSPPTQHTGQ-PPGQ--PSAP---------------SQLSAPRRYSSSLS 706
Query: 686 P-KATNGPMPGSGPTKTPSFHIK---RPAPRPLAHHKEGDADSFSKVRPPGEKPTIIRPP 741
P +A N P P TP H K + P P+A E + S P + P
Sbjct: 707 PIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPP--------QTP 758
Query: 742 VRPPDPPCRAATPQKPEPKPDIVAGN 767
P PP P P P+ + GN
Sbjct: 759 TPPSTPPLGKQNPSLPAPQ-TLAGGN 783
>gi|91208437 GEM interacting protein [Homo sapiens]
Length = 970
Score = 99.0 bits (245), Expect = 2e-20
Identities = 96/391 (24%), Positives = 167/391 (42%), Gaps = 62/391 (15%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
V KC IE + + +G+YR GS ++V++L AF + + ++ NS D+ ++ L
Sbjct: 568 VTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQAFENGRALVELS-GNSPHDVSSV---L 623
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYR------------LGAIHSLVYKLPEKNR 497
K +L+ L+EPV+ + L+ +S AK+ + D + ++ +L+ +LP+ N
Sbjct: 624 KRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGTPSPSPEVIRSLKTLLVQLPDSNY 683
Query: 498 EMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMR-------AQEDTVAAMMNIKFQN 550
L L+ HL V EN M+ +N+G++FGPTL+R A V +++ Q
Sbjct: 684 NTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLRPPDGPRAASAIPVTCLLDSGHQA 743
Query: 551 IVVEILIEHFGKIYLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDES 610
+VE LI H+ +I+ +E PPP+ ++ P+T S S
Sbjct: 744 QLVEFLIVHYEQIF--GMDELPQATEPPPQDSSPAPGPLTTS-----------------S 784
Query: 611 EDEIQHQTPNG--TITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDGKLEPCPEV 668
+ H P+ + +S P P H L P P P+
Sbjct: 785 QPPPPHLDPDSQPPVLASDPGPDPQHHSTL--------------EQHPTATPTEIPTPQS 830
Query: 669 DVGKLVSR-LQDGGTKITPKATNGPMPGS---GPTKTPSFHIKRPAPRPLAHHKEGDADS 724
D + V+ +DGG +++ + + G+ G R RP+ H A
Sbjct: 831 DQREDVAEDTKDGGGEVSSQGPEDSLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALV 890
Query: 725 FSKVRPPGEKPTIIRPPVRPPDPPCRAATPQ 755
SK+ ++ R +R P AA+P+
Sbjct: 891 ASKLCEETPITSVPRGSLRGRGPSPAAASPE 921
>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
Length = 818
Score = 98.6 bits (244), Expect = 2e-20
Identities = 64/220 (29%), Positives = 113/220 (51%), Gaps = 13/220 (5%)
Query: 353 EANRRLWMEAMDGKEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVG 412
+A + W+E +P + P+ + + E+ F + C+ ++ G++ EGL+R
Sbjct: 241 KAQQEAWVE-----KPSFGKPLEEHLTISGREIAFP-IEACVTMLLECGMQEEGLFRVAP 294
Query: 413 SNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSLKFYLRNLSEPVMTYRLHKELVSA 472
S +++KL A C DV +++D I +LK YLR L EP+MT+ L+ E + A
Sbjct: 295 SASKLKKLKAAL--DCCVVDVQEYSAD--PHAIAGALKSYLRELPEPLMTFELYDEWIQA 350
Query: 473 AKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTL 532
+ D +L A+ + KLP+ N + LI+ L + E+ N MTPSNM ++ GP L
Sbjct: 351 SNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNL 410
Query: 533 M--RAQEDTVAAMMNIKFQNI-VVEILIEHFGKIYLGPPE 569
+ +A+ + M + Q + ++E +I+H + G E
Sbjct: 411 LWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIE 450
Score = 31.2 bits (69), Expect = 4.0
Identities = 58/222 (26%), Positives = 84/222 (37%), Gaps = 42/222 (18%)
Query: 567 PPEESAAP-PVPPPRV-----TARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPN 620
PP E AAP P P P A P + + ERT T S + S Q +P
Sbjct: 548 PPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTST-TKSKELSPGSAQKGSPG 606
Query: 621 GTITSSIEPPKPPQHPKLPIQRSGETDPGRKSPSRPILDG----------KLEPCP-EVD 669
+ ++ +P P G SPS+P D KL P P +V
Sbjct: 607 SSQGTACAGTQPGAQP-------GAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVP 659
Query: 670 VGKLVSRLQDGGTKITPKATNGPMPGSGPT----------KTPSFHIKRPAPRPLAHHKE 719
G+ + + +P + + P P S P+ S + A PLA
Sbjct: 660 FGQPGAMADQSAGQPSPVSLS-PTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSV 718
Query: 720 GDADSFSKVRP---PGEKPTIIRPPVRPPDPPCRAATPQKPE 758
+ + SK RP P ++PT+ PP +PP A++PQ E
Sbjct: 719 FTS-TLSKSRPTPKPRQRPTL--PPPQPPTVNLSASSPQSTE 757
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/192 (31%), Positives = 91/192 (47%), Gaps = 4/192 (2%)
Query: 389 FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSS 448
FV KC+ IE G+ TEGLYR G+ + F +++ + + + + +
Sbjct: 1277 FVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDH---NINLVSMEVTVNAVAGA 1333
Query: 449 LKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLV 508
LK + +L +P++ Y LH EL+ AAK + RL A+ +V K N ++ +I HL
Sbjct: 1334 LKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLN 1393
Query: 509 NVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFG-KIYLGP 567
V + K NLMT N+ + F PTLMR + + K VVE I+ Y G
Sbjct: 1394 RVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGE 1453
Query: 568 PEESAAPPVPPP 579
E+ PPP
Sbjct: 1454 IVETTNIVAPPP 1465
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 97.1 bits (240), Expect = 6e-20
Identities = 60/192 (31%), Positives = 91/192 (47%), Gaps = 4/192 (2%)
Query: 389 FVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSS 448
FV KC+ IE G+ TEGLYR G+ + F +++ + + + + +
Sbjct: 1276 FVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDH---NINLVSMEVTVNAVAGA 1332
Query: 449 LKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLV 508
LK + +L +P++ Y LH EL+ AAK + RL A+ +V K N ++ +I HL
Sbjct: 1333 LKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHPVNYDVFRYVITHLN 1392
Query: 509 NVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFG-KIYLGP 567
V + K NLMT N+ + F PTLMR + + K VVE I+ Y G
Sbjct: 1393 RVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSVVETFIQQCQFFFYNGE 1452
Query: 568 PEESAAPPVPPP 579
E+ PPP
Sbjct: 1453 IVETTNIVAPPP 1464
>gi|186928844 Cdc42 GTPase-activating protein [Homo sapiens]
Length = 1444
Score = 94.7 bits (234), Expect = 3e-19
Identities = 53/181 (29%), Positives = 94/181 (51%), Gaps = 8/181 (4%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
++ C IET GI +G+YR G +Q+L F +CP D+ DI + S
Sbjct: 38 LKSCAEFIETHGI-VDGIYRLSGVTSNIQRLRQEFGSDQCP-DLTREVYLQDIHCVGSLC 95
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVN 509
K Y R L P++TY L+++ A + +L I +++ +LP + LE LIRHL +
Sbjct: 96 KLYFRELPNPLLTYELYEKFTEAVSHCPEEGQLARIQNVIQELPPSHYRTLEYLIRHLAH 155
Query: 510 VCEHSKENLMTPSNMGVIFGPTLMRAQE------DTVAAMMNIKFQNIVVEILIEHFGKI 563
+ S + M N+ +++ P L+R++E + AA + ++ Q +V+E ++ H +I
Sbjct: 156 IASFSSKTNMHARNLALVWAPNLLRSKEIEATGCNGDAAFLAVRVQQVVIEFILNHVDQI 215
Query: 564 Y 564
+
Sbjct: 216 F 216
>gi|112363100 SLIT-ROBO Rho GTPase activating protein 2 isoform a
[Homo sapiens]
Length = 1071
Score = 94.0 bits (232), Expect = 5e-19
Identities = 129/596 (21%), Positives = 235/596 (39%), Gaps = 82/596 (13%)
Query: 9 SDCYLDS--PDF----RERLKCYEQELERTNKFIKDVIKDGNALISAMRNY------SSA 56
SD YL++ P F + + +++ E + D++K N L S M+ Y S +
Sbjct: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
Query: 57 VQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPL 116
Q + + + IG ++ ++ S A + E ++ R V K +
Sbjct: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSV--------KKI 228
Query: 117 ENFR-KEQIGFTKERKKKFEKDGERFYSL----------------------LDRHLHLSS 153
E + K Q +T+ + K + E +L D H S
Sbjct: 229 EKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASL 288
Query: 154 KKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKF-----NIVEPVLAFLHSLF 208
+ A+L +++ +H ++ + V + + ++ N+ P + F
Sbjct: 289 NRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPH 348
Query: 209 ISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTI 268
+ + + Q P + +L Q ++ S+ + E EE+KK M+ QT + T+
Sbjct: 349 MGDMASQLCAQQ--PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQT--IQDIVTV 404
Query: 269 EGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTES 328
E + + +Y E T++ T M + AK RR +
Sbjct: 405 EDFDVSD--------CFQYSNSMESVKSTVSETFMSKPSIAK------------RRANQQ 444
Query: 329 IDKRFCFDI--ETNERPGTIT-LQALSEANRRLWMEAM--DGKEPIYHSPITKQQEMELN 383
++F F E E IT LQA + ++ E+ D S + KQ +
Sbjct: 445 ETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAI 504
Query: 384 EVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIK 443
+ V CI I G++ EG++R GS ++V + NAF + P D +D D+
Sbjct: 505 PL---VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD--QNDHDMD 559
Query: 444 TITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELL 503
+I LK Y R L P+ + +L++ DNL R I ++ LP+ ++ L
Sbjct: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
Query: 504 IRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEH 559
L ++ + S+EN+M P N+ + FGP+LM E ++ I+I+H
Sbjct: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQH 675
>gi|112363096 SLIT-ROBO Rho GTPase activating protein 2 isoform b
[Homo sapiens]
Length = 836
Score = 94.0 bits (232), Expect = 5e-19
Identities = 129/596 (21%), Positives = 235/596 (39%), Gaps = 82/596 (13%)
Query: 9 SDCYLDS--PDF----RERLKCYEQELERTNKFIKDVIKDGNALISAMRNY------SSA 56
SD YL++ P F + + +++ E + D++K N L S M+ Y S +
Sbjct: 117 SDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSIS 176
Query: 57 VQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVHNASDLLIKPL 116
Q + + + IG ++ ++ S A + E ++ R V K +
Sbjct: 177 AQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSV--------KKI 228
Query: 117 ENFR-KEQIGFTKERKKKFEKDGERFYSL----------------------LDRHLHLSS 153
E + K Q +T+ + K + E +L D H S
Sbjct: 229 EKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASL 288
Query: 154 KKKESQLQEADLQVDKERHNFFESSLDYVYQIQEVQESKKF-----NIVEPVLAFLHSLF 208
+ A+L +++ +H ++ + V + + ++ N+ P + F
Sbjct: 289 NRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPH 348
Query: 209 ISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTI 268
+ + + Q P + +L Q ++ S+ + E EE+KK M+ QT + T+
Sbjct: 349 MGDMASQLCAQQ--PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQT--IQDIVTV 404
Query: 269 EGYLYTQEKWALGISWVKYYCQYEKETKTLTMTPMEQKPGAKQGPLDLTLKYCVRRKTES 328
E + + +Y E T++ T M + AK RR +
Sbjct: 405 EDFDVSD--------CFQYSNSMESVKSTVSETFMSKPSIAK------------RRANQQ 444
Query: 329 IDKRFCFDI--ETNERPGTIT-LQALSEANRRLWMEAM--DGKEPIYHSPITKQQEMELN 383
++F F E E IT LQA + ++ E+ D S + KQ +
Sbjct: 445 ETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAI 504
Query: 384 EVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIK 443
+ V CI I G++ EG++R GS ++V + NAF + P D +D D+
Sbjct: 505 PL---VVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGD--QNDHDMD 559
Query: 444 TITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELL 503
+I LK Y R L P+ + +L++ DNL R I ++ LP+ ++ L
Sbjct: 560 SIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALHIRKVLLVLPKTTLIIMRYL 619
Query: 504 IRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEH 559
L ++ + S+EN+M P N+ + FGP+LM E ++ I+I+H
Sbjct: 620 FAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQH 675
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 93.6 bits (231), Expect = 7e-19
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 21/270 (7%)
Query: 390 VRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFHNSDWDIKTITSSL 449
+R C IE G+ +G+YR G + +Q+L + F + P ++ DI +++S
Sbjct: 332 LRCCSEFIEAHGV-VDGIYRLSGVSSNIQRLRHEFDSERIP-ELSGPAFLQDIHSVSSLC 389
Query: 450 KFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIRHLVN 509
K Y R L P++TY+L+ + A + RL +H ++ +LP + LE L+RHL
Sbjct: 390 KLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLAR 449
Query: 510 VCEHSKENLMTPSNMGVIFGPTLMRAQE------DTVAAMMNIKFQNIVVEILIEHFGKI 563
+ HS M N+ +++ P L+R+ E AA ++ Q++VVE L+ H +
Sbjct: 450 MARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVL 509
Query: 564 YLGPPEESAAPPVPPPRVTARRHKPITISKRLLRERTVFYTSSLDESEDEIQHQTPNGTI 623
+ ++A P R R K + S R T+ +E Q +T G +
Sbjct: 510 F--SDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTL----------EEAQART-QGRL 556
Query: 624 TSSIEPPKPPQHPKLPIQRSGETDPGRKSP 653
+ EP P +R GE ++ P
Sbjct: 557 GTPTEPTTPKAPASPAERRKGERGEKQRKP 586
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,015,502
Number of Sequences: 37866
Number of extensions: 1881471
Number of successful extensions: 13707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 496
Number of HSP's that attempted gapping in prelim test: 11063
Number of HSP's gapped (non-prelim): 2479
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.