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Search of human proteins with 4504975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
(860 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 1842 0.0
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 911 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 880 0.0
gi|65301119 low density lipoprotein receptor-related protein 8 i... 819 0.0
gi|61744471 low density lipoprotein receptor-related protein 8 i... 808 0.0
gi|61744467 low density lipoprotein receptor-related protein 8 i... 699 0.0
gi|66082554 low density lipoprotein receptor-related protein 8 i... 683 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 557 e-158
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 503 e-142
gi|93102379 low density lipoprotein-related protein 1B precursor... 492 e-139
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 487 e-137
gi|148727288 low density lipoprotein receptor-related protein 6 ... 230 5e-60
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 229 1e-59
gi|4507157 sortilin-related receptor containing LDLR class A rep... 228 1e-59
gi|119709832 low density lipoprotein receptor-related protein 5 ... 228 2e-59
gi|134031945 SCO-spondin [Homo sapiens] 195 2e-49
gi|115298674 nidogen 1 precursor [Homo sapiens] 144 3e-34
gi|29244926 corin [Homo sapiens] 137 3e-32
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 131 2e-30
gi|144953895 nidogen 2 precursor [Homo sapiens] 129 1e-29
gi|11415040 matriptase [Homo sapiens] 128 2e-29
gi|32698824 low density lipoprotein receptor-related protein 5-l... 125 2e-28
gi|209447022 low density lipoprotein receptor-related protein 5-... 125 2e-28
gi|66346695 fibrillin 2 precursor [Homo sapiens] 101 3e-21
gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens] 100 6e-21
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 100 1e-20
gi|28557796 low density lipoprotein receptor class A domain cont... 99 1e-20
gi|46249414 latent transforming growth factor beta binding prote... 99 2e-20
gi|46249412 latent transforming growth factor beta binding prote... 99 2e-20
gi|167555125 low density lipoprotein receptor-related protein 3 ... 95 3e-19
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 1842 bits (4772), Expect = 0.0
Identities = 860/860 (100%), Positives = 860/860 (100%)
Query: 1 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ 60
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ
Sbjct: 1 MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ 60
Query: 61 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK 120
ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK
Sbjct: 61 ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK 120
Query: 121 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 180
CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW
Sbjct: 121 CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW 180
Query: 181 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE
Sbjct: 181 PQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
Query: 241 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR 300
FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR
Sbjct: 241 FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMAR 300
Query: 301 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD
Sbjct: 301 DCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
Query: 361 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT 420
PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT
Sbjct: 361 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT 420
Query: 421 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA 480
SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA
Sbjct: 421 SLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLA 480
Query: 481 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA 540
VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA
Sbjct: 481 VDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA 540
Query: 541 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE 600
KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE
Sbjct: 541 KIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILE 600
Query: 601 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ 660
DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ
Sbjct: 601 DEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQ 660
Query: 661 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA 720
PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA
Sbjct: 661 PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVA 720
Query: 721 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN 780
TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN
Sbjct: 721 TQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGN 780
Query: 781 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH 840
EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH
Sbjct: 781 EKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICH 840
Query: 841 NQDGYSYPSRQMVSLEDDVA 860
NQDGYSYPSRQMVSLEDDVA
Sbjct: 841 NQDGYSYPSRQMVSLEDDVA 860
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 911 bits (2354), Expect = 0.0
Identities = 425/841 (50%), Positives = 552/841 (65%), Gaps = 46/841 (5%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C ++F C +G+C+ +W CDG +C+DGSDES E C TC+ + SCG +CIP
Sbjct: 72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVS 131
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
WRCDG+ DCD+G DE+ C TCS DEF C G+CISR FVC+ DC DGSDE C
Sbjct: 132 WRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
Query: 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLS 206
TCG FQC++S+CIP W CD+D DC D SDE ++C V + C A E C S
Sbjct: 192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGS 248
Query: 207 GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
GECIH WRCDG PDCKD SDE NC TCRPD+F+C DG+CIHGSRQC+ DC D SD
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSD 308
Query: 267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCS 326
EV C NV C GP KFKC SGECI + KVCN +DCRDWSDEP+KEC NECL NNGGCS
Sbjct: 309 EVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS 368
Query: 327 HVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLD 386
H+C DL IGYEC C GF+L+ ++ C DIDECQ+P CSQ+C+NL+GGYKC+C G+Q+D
Sbjct: 369 HICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMD 428
Query: 387 PHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDL 446
T CKAVG L FTNR ++RK+ L+R EY L+ LRN VALD ++A+ +++W+DL
Sbjct: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADL 488
Query: 447 SQRMICSTQLDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTK 504
SQ+ I S +D G V D V + P +AVDW++ IYWTD+ T+SVA
Sbjct: 489 SQKAIFSASIDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLD 543
Query: 505 GVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564
G KRK LF + +P +I VDP+ GF+YW+DWG PAKI+K G+NG D LVT +IQWPN
Sbjct: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
Query: 565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII 624
GITLDL+ RLYW+DSKLH +SS+D+NG +R+ +L+ + LAHP +L +FED+V+W D
Sbjct: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
Query: 625 NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA 684
NEA++ AN+ TGS++ L NL +D++++H L QP G NWCE + NGGC+YLCLPA
Sbjct: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEE-DMENGGCEYLCLPA 722
Query: 685 PQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTR 744
PQIN HSPK+TC+CP G + + R C Q T+T + T T+ T T
Sbjct: 723 PQINDHSPKYTCSCPSGYNVEENGRDC----------QSTAT-----TVTYSETKDTNTT 767
Query: 745 PVPDTSRL-PGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLC 803
+ TS L PG T V V++ P A +LP++LLV
Sbjct: 768 EISATSGLVPGGINVTTAVSEVSV---------------PPKGTSAAWAILPLLLLVMAA 812
Query: 804 LGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQD----GYSYPSRQMVSLEDDV 859
+G +L+W+NW+ KN+ S+NFDNPVY KTTE+++ I + G++YP+ +VS +DD+
Sbjct: 813 VGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDL 872
Query: 860 A 860
A
Sbjct: 873 A 873
Score = 210 bits (535), Expect = 4e-54
Identities = 114/309 (36%), Positives = 150/309 (48%), Gaps = 47/309 (15%)
Query: 109 CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACD 168
C +F+C +G+CI+ + CD D DC+DGSDE +C TC + F CN+ C+P W CD
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92
Query: 169 NDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC--LSGECIHSSWRCDGGPDCKDKS 226
DPDCEDGSDE P++C C E C S +CI SWRCDG DC
Sbjct: 93 GDPDCEDGSDESPEQCH--------MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
Query: 227 DEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHS 286
DEENC TC PDEF CS G CI + C+ + DC D SDE+ C T G ++F+C +
Sbjct: 145 DEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTC--GAHEFQCST 202
Query: 287 GECITLDKVCNMARDCRDWSDEPIKECG----------TNECLDNNGGCSHV-------- 328
CI + VC+ DC D SDE +++CG +E +G C H
Sbjct: 203 SSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDP 262
Query: 329 -CNDLKIGYEC----------LCPDGFQLVAQRRCEDIDEC---QDPDTCSQL--CVNLE 372
C D C C DG + R+C I +C D C + C+
Sbjct: 263 DCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG-P 321
Query: 373 GGYKCQCEE 381
G +KC+ E
Sbjct: 322 GKFKCRSGE 330
Score = 104 bits (259), Expect = 4e-22
Identities = 61/187 (32%), Positives = 83/187 (44%), Gaps = 47/187 (25%)
Query: 192 GDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHG 251
G + C +F C +G CI W+CDG DC D SDE+NC TC +F C++G C+
Sbjct: 28 GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS 87
Query: 252 SRQCDREYDCKDMSDE---------------------VGCVNVT-LCEG----------- 278
+CD + DC+D SDE C+ V+ C+G
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE 147
Query: 279 --------PNKFKCHSGECITLDKVCNMARDCRDWSDE---PIKECGTNECLDNNGGC-- 325
P++F C SG CI+ + VCN DC D SDE CG +E + C
Sbjct: 148 NCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
Query: 326 -SHVCND 331
S VC+D
Sbjct: 208 ISWVCDD 214
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 880 bits (2275), Expect = 0.0
Identities = 412/840 (49%), Positives = 538/840 (64%), Gaps = 72/840 (8%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C ++F C +G+C+ +W CDG +C+DGSDES E C TC+ + SCG +CIP
Sbjct: 72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVS 131
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
WRCDG+ DCD+G DE+ C TCS DEF C G+CISR FVC+ DC DGSDE C
Sbjct: 132 WRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
Query: 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLS 206
TCG FQC++S+CIP W CD+D DC D SDE ++C V + C A E C S
Sbjct: 192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGS 248
Query: 207 GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
GECIH WRCDG PDCKD SDE NC TCRPD+F+C DG+CIHGSRQC+ DC D SD
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSD 308
Query: 267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCS 326
EV C NV C GP KFKC SGECI + KVCN +DCRDWSDEP+KEC NECL NNGGCS
Sbjct: 309 EVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS 368
Query: 327 HVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLD 386
H+C DL IGYEC C GF+L+ ++ C DIDECQ+P CSQ+C+NL+GGYKC+C G+Q+D
Sbjct: 369 HICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMD 428
Query: 387 PHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDL 446
T CKAVG L FTNR ++RK+ L+R EY L+ LRN VALD ++A+ +++W+DL
Sbjct: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADL 488
Query: 447 SQRMICSTQLDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTK 504
SQ+ I S +D G V D V + P +AVDW++ IYWTD+ T+SVA
Sbjct: 489 SQKAIFSASIDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLD 543
Query: 505 GVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564
G KRK LF + +P +I VDP+ GF+YW+DWG PAKI+K G+NG D LVT +IQWPN
Sbjct: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
Query: 565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII 624
GITLDL+ RLYW+DSKLH +SS+D+NG +R+ +L+ + LAHP +L +FED+V+W D
Sbjct: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
Query: 625 NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA 684
NEA++ AN+ TGS++ L NL +D++++H L QP G NWCE + NGGC+YLCLPA
Sbjct: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEE-DMENGGCEYLCLPA 722
Query: 685 PQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTR 744
PQIN HSPK+TC+CP G + + R C + V VS +V + T
Sbjct: 723 PQINDHSPKYTCSCPSGYNVEENGRDC-----------QRINVTTAVSEVSVPPKGT--- 768
Query: 745 PVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL 804
S+ A+ +L +V+ +
Sbjct: 769 ----------------------------------------SAAWAILPLLLLVM---AAV 785
Query: 805 GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQD----GYSYPSRQMVSLEDDVA 860
G +L+W+NW+ KN+ S+NFDNPVY KTTE+++ I + G++YP+ +VS +DD+A
Sbjct: 786 GGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 845
Score = 210 bits (535), Expect = 4e-54
Identities = 114/309 (36%), Positives = 150/309 (48%), Gaps = 47/309 (15%)
Query: 109 CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACD 168
C +F+C +G+CI+ + CD D DC+DGSDE +C TC + F CN+ C+P W CD
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92
Query: 169 NDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC--LSGECIHSSWRCDGGPDCKDKS 226
DPDCEDGSDE P++C C E C S +CI SWRCDG DC
Sbjct: 93 GDPDCEDGSDESPEQCH--------MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
Query: 227 DEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHS 286
DEENC TC PDEF CS G CI + C+ + DC D SDE+ C T G ++F+C +
Sbjct: 145 DEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTC--GAHEFQCST 202
Query: 287 GECITLDKVCNMARDCRDWSDEPIKECG----------TNECLDNNGGCSHV-------- 328
CI + VC+ DC D SDE +++CG +E +G C H
Sbjct: 203 SSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDP 262
Query: 329 -CNDLKIGYEC----------LCPDGFQLVAQRRCEDIDEC---QDPDTCSQL--CVNLE 372
C D C C DG + R+C I +C D C + C+
Sbjct: 263 DCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLG-P 321
Query: 373 GGYKCQCEE 381
G +KC+ E
Sbjct: 322 GKFKCRSGE 330
Score = 104 bits (259), Expect = 4e-22
Identities = 61/187 (32%), Positives = 83/187 (44%), Gaps = 47/187 (25%)
Query: 192 GDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHG 251
G + C +F C +G CI W+CDG DC D SDE+NC TC +F C++G C+
Sbjct: 28 GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS 87
Query: 252 SRQCDREYDCKDMSDE---------------------VGCVNVT-LCEG----------- 278
+CD + DC+D SDE C+ V+ C+G
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE 147
Query: 279 --------PNKFKCHSGECITLDKVCNMARDCRDWSDE---PIKECGTNECLDNNGGC-- 325
P++F C SG CI+ + VCN DC D SDE CG +E + C
Sbjct: 148 NCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
Query: 326 -SHVCND 331
S VC+D
Sbjct: 208 ISWVCDD 214
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 819 bits (2115), Expect = 0.0
Identities = 434/906 (47%), Positives = 555/906 (61%), Gaps = 94/906 (10%)
Query: 14 LLLAAAGTAVGDR-----CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTC 68
L AAA +G + CE+++FQC++ +CI W CD +C D SDE + C TC
Sbjct: 29 LAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTC 86
Query: 69 KSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCH--DGKCISR 124
DF+C CI + W+CDG+ +C +GSDE C + C ++ C KC+
Sbjct: 87 ADSDFTCDN--GHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 125 QFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
+ CD ++DC G+DEA C L C P FQC + +C+ ++ CD D DC DGSDE
Sbjct: 145 SWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE----- 198
Query: 185 RGLYVFQGDSSP-CSAFEFHCLS---GECIHSSWRCDGGPDCKDKSDE--ENC------- 231
+G + P C EF C G CI W CD DC+D+SDE E C
Sbjct: 199 ------RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGA 252
Query: 232 --AVATCRP-DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGE 288
A A C +F C G C+H +CD + DCKD SDE C T C G ++F+C G
Sbjct: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT-CRG-DEFQCGDGT 310
Query: 289 CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVA 348
C+ K CN +DC D SDE G NECL NNGGCSH+C DLKIG+EC CP GFQL+
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
Query: 349 QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV-GSIAYLFFTNRH 407
Q+ C DIDEC+DPD CSQ+CVN +G +KC+C G+++D TK CKA G L FTNRH
Sbjct: 371 QKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRH 430
Query: 408 EVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDT 467
EVR++ L + Y+ LIP L+NVVALD EVA+NRIYW DLS R I S +D+A +
Sbjct: 431 EVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 468 VISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPV 527
+I + +P+GLAVDW+H +IYWTDS T+SVA G +R+TLF N S+PRAI VDP+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 528 HGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISS 587
GFMYW+DWG AKI+K GLNGVD +LV++NI+WPNGITLDLLS RLYWVDSKLH +SS
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
Query: 588 IDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLL 647
ID +GGNRKT++ L+HPF +AVFEDKVFWTD+ NEAIFSANRL G ++++LAENL
Sbjct: 611 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN 670
Query: 648 SPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD 707
+P D+V+FH L QPR + CE + NGGC+YLCLPAPQI+ HSPK+TCACPD M L D
Sbjct: 671 NPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
Query: 708 MRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA------------ 755
M+ C A Q TST L T TR VP T+R PG
Sbjct: 731 MKRCYR------APQSTSTTTL---------ASTMTRTVPATTRAPGTTVHRSTYQNHST 775
Query: 756 -TPGLT-------------TVEIVTMSHQALGDVAGRGNE--KKPSSVRA--LSIVLPIV 797
TP LT ++ T+S NE K S+V A + I++PIV
Sbjct: 776 ETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIV 835
Query: 798 LLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTT----EDEVHICHN-QDGYSYPSRQM 852
++ LC+ +L+W+NW+ KN S+NFDNPVY+KTT EDE+HI Q G+ YP+R
Sbjct: 836 VIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVA 895
Query: 853 VSLEDD 858
+SLEDD
Sbjct: 896 LSLEDD 901
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 808 bits (2087), Expect = 0.0
Identities = 428/897 (47%), Positives = 548/897 (61%), Gaps = 94/897 (10%)
Query: 14 LLLAAAGTAVGDR-----CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTC 68
L AAA +G + CE+++FQC++ +CI W CD +C D SDE + C TC
Sbjct: 29 LAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTC 86
Query: 69 KSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCH--DGKCISR 124
DF+C CI + W+CDG+ +C +GSDE C + C ++ C KC+
Sbjct: 87 ADSDFTCDN--GHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 125 QFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC 184
+ CD ++DC G+DEA C L C P FQC + +C+ ++ CD D DC DGSDE
Sbjct: 145 SWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE----- 198
Query: 185 RGLYVFQGDSSP-CSAFEFHCLS---GECIHSSWRCDGGPDCKDKSDE--ENC------- 231
+G + P C EF C G CI W CD DC+D+SDE E C
Sbjct: 199 ------RGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGA 252
Query: 232 --AVATCRP-DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGE 288
A A C +F C G C+H +CD + DCKD SDE C T C G ++F+C G
Sbjct: 253 TSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGT-CRG-DEFQCGDGT 310
Query: 289 CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVA 348
C+ K CN +DC D SDE G NECL NNGGCSH+C DLKIG+EC CP GFQL+
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLD 370
Query: 349 QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV-GSIAYLFFTNRH 407
Q+ C DIDEC+DPD CSQ+CVN +G +KC+C G+++D TK CKA G L FTNRH
Sbjct: 371 QKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRH 430
Query: 408 EVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDT 467
EVR++ L + Y+ LIP L+NVVALD EVA+NRIYW DLS R I S +D+A +
Sbjct: 431 EVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEV 490
Query: 468 VISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPV 527
+I + +P+GLAVDW+H +IYWTDS T+SVA G +R+TLF N S+PRAI VDP+
Sbjct: 491 LIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPL 550
Query: 528 HGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISS 587
GFMYW+DWG AKI+K GLNGVD +LV++NI+WPNGITLDLLS RLYWVDSKLH +SS
Sbjct: 551 RGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSS 610
Query: 588 IDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLL 647
ID +GGNRKT++ L+HPF +AVFEDKVFWTD+ NEAIFSANRL G ++++LAENL
Sbjct: 611 IDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLN 670
Query: 648 SPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD 707
+P D+V+FH L QPR + CE + NGGC+YLCLPAPQI+ HSPK+TCACPD M L D
Sbjct: 671 NPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPD 730
Query: 708 MRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA------------ 755
M+ C A Q TST L T TR VP T+R PG
Sbjct: 731 MKRCYR------APQSTSTTTL---------ASTMTRTVPATTRAPGTTVHRSTYQNHST 775
Query: 756 -TPGLT-------------TVEIVTMSHQALGDVAGRGNE--KKPSSVRA--LSIVLPIV 797
TP LT ++ T+S NE K S+V A + I++PIV
Sbjct: 776 ETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIV 835
Query: 798 LLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTT----EDEVHICHN-QDGYSYPS 849
++ LC+ +L+W+NW+ KN S+NFDNPVY+KTT EDE+HI Q G+ YP+
Sbjct: 836 VIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA 892
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 699 bits (1804), Expect = 0.0
Identities = 361/764 (47%), Positives = 460/764 (60%), Gaps = 119/764 (15%)
Query: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQL 164
P K C +D+F+C + +CI + CD D DCLD SDE CP TC + F C++ CI +
Sbjct: 43 PAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
Query: 165 WACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC--LSGECIHSSWRCDGGPDC 222
W CD + +C DGSDE C C A + C S +C+ +SWRCDG DC
Sbjct: 103 WKCDGEEECPDGSDESEATC--------TKQVCPAEKLSCGPTSHKCVPASWRCDGEKDC 154
Query: 223 KDKSDEENCA--VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPN 280
+ +DE CA + TCR DEFQC DG C+ + C++E DC D SDE GC+
Sbjct: 155 EGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQ-------- 206
Query: 281 KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLC 340
G NECL NNGGCSH+C DLKIG+EC C
Sbjct: 207 ---------------------------------GLNECLHNNGGCSHICTDLKIGFECTC 233
Query: 341 PDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACK-AVGSIA 399
P GFQL+ Q+ C DIDEC+DPD CSQ+CVN +G +KC+C G+++D TK CK A G
Sbjct: 234 PAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSP 293
Query: 400 YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRA 459
L FTNRHEVR++ L + Y+ LIP L+NVVALD EVA+NRIYW DLS R I S +D+A
Sbjct: 294 SLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKA 353
Query: 460 HGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKP 519
+ +I + +P+GLAVDW+H +IYWTDS T+SVA G +R+TLF N S+P
Sbjct: 354 SDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEP 413
Query: 520 RAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579
RAI VDP+ GFMYW+DWG AKI+K GLNGVD +LV++NI+WPNGITLDLLS RLYWVD
Sbjct: 414 RAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVD 473
Query: 580 SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDV 639
SKLH +SSID +GGNRKT++ L+HPF +AVFEDKVFWTD+ NEAIFSANRL G ++
Sbjct: 474 SKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEI 533
Query: 640 NLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACP 699
++LAENL +P D+V+FH L QPR + CE + NGGC+YLCLPAPQI+ HSPK+TCACP
Sbjct: 534 SILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACP 593
Query: 700 DGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGL 759
D M L DM+ C +A E S K+ ST T+ + G +
Sbjct: 594 DTMWLGPDMKRCYRDA------NEDS----KMGSTV-------------TAAVIGIIVPI 630
Query: 760 TTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNIN 819
+ ++ MS G + R ++K N
Sbjct: 631 VVIALLCMS----GYLIWRNWKRK---------------------------------NTK 653
Query: 820 SINFDNPVYQKTT----EDEVHICHN-QDGYSYPSRQMVSLEDD 858
S+NFDNPVY+KTT EDE+HI Q G+ YP+R +SLEDD
Sbjct: 654 SMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPARVALSLEDD 697
Score = 138 bits (348), Expect = 2e-32
Identities = 57/119 (47%), Positives = 74/119 (62%), Gaps = 2/119 (1%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C ++F C +G CI +W CDG EC DGSDES+ TC C + SCG ++C+P
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPAS 145
Query: 87 WRCDGQVDCDNGSDEQGCPPK--TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
WRCDG+ DC+ G+DE GC TC DEF+C DG C+ C+ ++DC DGSDEA C
Sbjct: 146 WRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 683 bits (1763), Expect = 0.0
Identities = 349/697 (50%), Positives = 442/697 (63%), Gaps = 53/697 (7%)
Query: 191 QGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIH 250
QG + C +F C + CI S WRCD DC D SDE++C TC +F C +G+CIH
Sbjct: 41 QGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 251 GSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCH--SGECITLDKVCNMARDCRDWSDE 308
+CD E +C D SDE K C S +C+ C+ +DC +DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC 368
NECL NNGGCSH+C DLKIG+EC CP GFQL+ Q+ C DIDEC+DPD CSQ+C
Sbjct: 161 AGCATWLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 220
Query: 369 VNLEGGYKCQCEEGFQLDPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLR 427
VN +G +KC+C G+++D TK CKA G L FTNRHEVR++ L + Y+ LIP L+
Sbjct: 221 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 280
Query: 428 NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSN 487
NVVALD EVA+NRIYW DLS R I S +D+A + +I + +P+GLAVDW+H +
Sbjct: 281 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 340
Query: 488 IYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGL 547
IYWTDS T+SVA G +R+TLF N S+PRAI VDP+ GFMYW+DWG AKI+K GL
Sbjct: 341 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 400
Query: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
NGVD +LV++NI+WPNGITLDLLS RLYWVDSKLH +SSID +GGNRKT++ L+H
Sbjct: 401 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 460
Query: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWC 667
PF +AVFEDKVFWTD+ NEAIFSANRL G ++++LAENL +P D+V+FH L QPR + C
Sbjct: 461 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 520
Query: 668 ERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTV 727
E + NGGC+YLCLPAPQI+ HSPK+TCACPD M L DM+ C A Q TST
Sbjct: 521 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYR------APQSTSTT 574
Query: 728 RLKVSSTAVRTQHTTTRPVPDTSRLPGA-------------TPGLT-------------T 761
L T TR VP T+R PG TP LT +
Sbjct: 575 TL---------ASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPS 625
Query: 762 VEIVTMSHQALGDVAGRGNE--KKPSSVRA--LSIVLPIVLLVFLCLGVFLLWKNWRLKN 817
+ T+S NE K S+V A + I++PIV++ LC+ +L+W+NW+ KN
Sbjct: 626 ISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKN 685
Query: 818 INSINFDNPVYQKTT----EDEVHICHN-QDGYSYPS 849
S+NFDNPVY+KTT EDE+HI Q G+ YP+
Sbjct: 686 TKSMNFDNPVYRKTTEEEDEDELHIGRTAQIGHVYPA 722
Score = 121 bits (304), Expect = 2e-27
Identities = 67/175 (38%), Positives = 87/175 (49%), Gaps = 27/175 (15%)
Query: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFV 127
C+ F C R RCIP WRCD DC + SDE CP KTC+ +F C +G CI ++
Sbjct: 47 CEKDQFQC--RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWK 104
Query: 128 CDSDRDCLDGSDEAS-------CPV--LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSD 178
CD + +C DGSDE+ CP L+CGP S + C+P W CD + DCE G+D
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHK-----CVPASWRCDGEKDCEGGAD 159
Query: 179 E-----WPQRCRGLYVFQGDSSPCS----AFEFHCLSGECIHSSWRCDGGPDCKD 224
E W C L+ G S C+ FE C +G + C +CKD
Sbjct: 160 EAGCATWLNEC--LHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKD 212
Score = 102 bits (255), Expect = 1e-21
Identities = 51/139 (36%), Positives = 75/139 (53%), Gaps = 13/139 (9%)
Query: 14 LLLAAAGTAVGDR-----CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTC 68
L AAA +G + CE+++FQC++ +CI W CD +C D SDE + C TC
Sbjct: 29 LAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTC 86
Query: 69 KSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQ--GCPPKTCSQDEFRC--HDGKCISR 124
DF+C CI + W+CDG+ +C +GSDE C + C ++ C KC+
Sbjct: 87 ADSDFTCDN--GHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 125 QFVCDSDRDCLDGSDEASC 143
+ CD ++DC G+DEA C
Sbjct: 145 SWRCDGEKDCEGGADEAGC 163
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 557 bits (1436), Expect = e-158
Identities = 278/686 (40%), Positives = 383/686 (55%), Gaps = 40/686 (5%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C +F C +GKCI WVCDG +C+D SDE + C C+ +F C CI
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPCQN--GYCIRSL 126
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
W CDG DC + SDEQ C + CS EFRC DG CI+ + CD D DC DGSDE +CP
Sbjct: 127 WHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 147 T----CGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
C FQC CI ++ CD D DC D SDE C PC + EF
Sbjct: 186 VPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDE--SDC-------SSHQPCRSGEF 236
Query: 203 HCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCK 262
C SG CI++ WRCDG DC D+SDE NC + C ++F+C G C+ S +CD E DC
Sbjct: 237 MCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCA 296
Query: 263 DMSDEVGCVNVTLCE-GPNKFKCHSGECITLDKVCNMARDCRDWSDE-PIKEC----GTN 316
D SDE C N + ++F C +G CI K+CN DC D SDE P + C G
Sbjct: 297 DNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEE 356
Query: 317 ECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLEGGY 375
C NNGGC+ C ++ +C C G++L C+D++EC + CSQ C N EG +
Sbjct: 357 NCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQGCTNSEGAF 416
Query: 376 KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTE 435
+C CE G++L P ++CKA+G L F NR ++R++ RSEYT L+ NL N +ALD
Sbjct: 417 QCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNLENAIALDFH 476
Query: 436 VASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVL 495
++WSD++ I L+ S+ + V+S +++P GLAVDW+H +YWTDS
Sbjct: 477 HRRELVFWSDVTLDRILRANLNG----SNVEEVVSTGLESPGGLAVDWVHDKLYWTDSGT 532
Query: 496 GTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSL 555
+ VA+ G RK L +N KPRAI + P+ G +YWTDWG +I+ ++G +
Sbjct: 533 SRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSMDGSGRRII 592
Query: 556 VTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFE 615
++ WPNG+T+D R+YWVD+K H I +++G +RK ++ + L HPF++ VFE
Sbjct: 593 ADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--SQGLPHPFAITVFE 650
Query: 616 DKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNG 675
D ++WTD ++I SAN+ TG + ++ L P D+ H QP G N C +NG
Sbjct: 651 DSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGD---NNG 707
Query: 676 GCQYLCLPAPQINPHSPKFTCACPDG 701
GC +LCLP+ Q +TCACP G
Sbjct: 708 GCTHLCLPSGQ------NYTCACPTG 727
Score = 235 bits (600), Expect = 1e-61
Identities = 133/402 (33%), Positives = 209/402 (51%), Gaps = 60/402 (14%)
Query: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG 373
G N C DNNGGC+H LC+
Sbjct: 698 GKNRCGDNNGGCTH---------------------------------------LCLPSGQ 718
Query: 374 GYKCQCEEGFQ-LDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS-LIP--NLRNV 429
Y C C GF+ + H AC A +L F R ++R+++ D + + +IP ++R+
Sbjct: 719 NYTCACPTGFRKISSH--AC-AQSLDKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSA 775
Query: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489
VALD + + +YW+D+S I + D + + V+ +++P GLA+DW+ + +Y
Sbjct: 776 VALDWDSRDDHVYWTDVSTDTISRAKWDG----TGQEVVVDTSLESPAGLAIDWVTNKLY 831
Query: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549
WTD+ + VA+T G R L EN +PR IVV+P+ G+MYWTDWG KI++ G++
Sbjct: 832 WTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMGGYMYWTDWGASPKIERAGMDA 891
Query: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609
+++ N+ WPNG+ +D S RLYW D+ + +I ++G RK ++ + L HPF
Sbjct: 892 SGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVLIGSQ--LPHPF 949
Query: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCER 669
L ++ ++++WTD ++I SA+RLTG D L ENL + D+ +FH P
Sbjct: 950 GLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPVST----P 1005
Query: 670 TTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
+ NGGC +LCL +P NP F+C CP G+ L D ++C
Sbjct: 1006 CAMENGGCSHLCLRSP--NPSG--FSCTCPTGINLLSDGKTC 1043
Score = 232 bits (591), Expect = 1e-60
Identities = 157/540 (29%), Positives = 255/540 (47%), Gaps = 92/540 (17%)
Query: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG 373
G N+C NGGCSH+C G+ C CP G QL D TC
Sbjct: 1309 GFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKG-----------DGKTC--------- 1348
Query: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL---IPNLRNVV 430
DP + YL F++R +R+++LD S++T + +P L NV+
Sbjct: 1349 ------------DPSPE--------TYLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVI 1388
Query: 431 ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYW 490
+LD + ++Y++D+ +I L+ S+ +TVI R ++ DGLAVDW+ N+YW
Sbjct: 1389 SLDYDSVDGKVYYTDVFLDVIRRADLNG----SNMETVIGRGLKTTDGLAVDWVARNLYW 1444
Query: 491 TDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGV 550
TD+ T+ + G RK L + +PRAI V P G+++WTDWG AKI++ L+G
Sbjct: 1445 TDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGYLFWTDWGHIAKIERANLDGS 1504
Query: 551 DIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFS 610
+ L+ ++ WPNG+TLD + R+YWVD+ L I S D+NG R+ ++ ++HPF+
Sbjct: 1505 ERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLV---SHVSHPFA 1561
Query: 611 LAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERT 670
L + ++WTD ++I ++ +G + + N+ D+++ Q G N C
Sbjct: 1562 LTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQ-TGTNAC--- 1617
Query: 671 TLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC------LTEAEAAVATQET 724
++NGGC +LC + F CACPD D R C + A A E
Sbjct: 1618 GVNNGGCTHLCF------ARASDFVCACPD----EPDSRPCSLVPGLVPPAPRATGMSEK 1667
Query: 725 STVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKP 784
S V T + + T TR L VE A + R N+ P
Sbjct: 1668 SPVLPNTPPTTLYSSTTRTR------------TSLEEVEGRCSERDARLGLCARSNDAVP 1715
Query: 785 SSV-RALSIVLPI-----VLLVFLCLGVFLLWKNWRLK----NINSINFDNPVYQKTTED 834
++ L I I +LL+ + + +L+++ + K + ++ + NP Y+ +T++
Sbjct: 1716 AAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSNPSYRTSTQE 1775
Score = 229 bits (585), Expect = 6e-60
Identities = 133/396 (33%), Positives = 202/396 (51%), Gaps = 28/396 (7%)
Query: 364 CSQLCVNLEG--GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS 421
CS LC+ G+ C C G L K C G ++L F R ++R ++LD +
Sbjct: 1013 CSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSP-GMNSFLIFARRIDIRMVSLDIPYFAD 1071
Query: 422 LIP----NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPD 477
++ ++N +A+ + ++YWSD + I LD S ++ +I+ +Q D
Sbjct: 1072 VVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISRANLDG----SQHEDIITTGLQTTD 1127
Query: 478 GLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWG 537
GLAVD I +YWTD+ + V + G RK L +N PRAIV+ GFMYWTDWG
Sbjct: 1128 GLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWG 1187
Query: 538 TPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKT 597
AK+++ G++G D L+ N+ WPNG+T+D S +L W D+ I + D+NG NR T
Sbjct: 1188 ENAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHT 1247
Query: 598 ILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHN 657
++ + HP+ L + + ++WTD +I A++ TGS+V L+ NL DM +
Sbjct: 1248 LVSP---VQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-D 1303
Query: 658 LTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEA 717
QP G N C NGGC +LCLP P F+CACP G+ L D ++C E
Sbjct: 1304 RAQPLGFNKCGS---RNGGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
Query: 718 AVATQETSTVRLKVSSTAVRTQHTTTR-PVPDTSRL 752
+ ++R T + HT PVP+ + +
Sbjct: 1355 YLLFSSRGSIRRISLDT---SDHTDVHVPVPELNNV 1387
Score = 42.0 bits (97), Expect = 0.002
Identities = 16/34 (47%), Positives = 21/34 (61%)
Query: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
P ++ GTN C NNGGC+H+C + C CPD
Sbjct: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCACPD 1641
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 503 bits (1295), Expect = e-142
Identities = 285/711 (40%), Positives = 384/711 (54%), Gaps = 52/711 (7%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT---CKSGDFSCGGRVNRCI 83
CER C + WVCDG+ +C D SDE C V C F+C RCI
Sbjct: 2660 CERTSL------CYAPSWVCDGANDCGDYSDERD--CPGVKRPRCPLNYFACPS--GRCI 2709
Query: 84 PQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS- 142
P W CD + DC++G DE C K CS+ +F C + +CIS+Q++CD DC DGSDEA+
Sbjct: 2710 PMSWTCDKEDDCEHGEDETHCN-KFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAH 2768
Query: 143 CPVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFE 201
C TCGP+SF C + C+P+ W CD D DC DG+DE LY +S C E
Sbjct: 2769 CEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADE-SIAAGCLY-----NSTCDDRE 2822
Query: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEE-NCAVATCRPDEFQCSDGNCIHGSR-QCDREY 259
F C + +CI + CD DC D SDE C TC P EF+C++G C+ + +CD E
Sbjct: 2823 FMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGEN 2882
Query: 260 DCKDMSDEVG----CVNVT-LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECG 314
DC D SDE C + C ++F C SG C+ +CN DC D SDE + C
Sbjct: 2883 DCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE--RGCH 2940
Query: 315 TNECLDNN-GGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLE 372
NECL GCS C DLKIG++C C GF+L R C D+DEC CSQ C+N
Sbjct: 2941 INECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTH 3000
Query: 373 GGYKCQCEEGFQL---DPHTKACKAV-GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRN 428
G YKC C EG+ DPH+ CKAV +L F NR+ +RK+ LD S YT L L N
Sbjct: 3001 GSYKCLCVEGYAPRGGDPHS--CKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNN 3058
Query: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRD-IQAPDGLAVDWIHSN 487
VALD + IYW+D++ + + + R H S V+ R + PDGLAVDW+ N
Sbjct: 3059 AVALDFDYREQMIYWTDVTTQ---GSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDWVGGN 3115
Query: 488 IYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGL 547
+YW D T+ V+ G R L +PRA+VVD +G++YWTDWG + I + G+
Sbjct: 3116 LYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGM 3175
Query: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
+G +V I WPNG+TLD ++ R+YW D++ I ++G NR +L + + H
Sbjct: 3176 DGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFASLDGSNRHVVLSQD--IPH 3233
Query: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWC 667
F+L +FED V+WTD ++I A++ TG++ LL L P D+ +FH L QP N
Sbjct: 3234 IFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFHALRQPDVPN-- 3291
Query: 668 ERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
++NGGC LCL +P CACP L D R+C++ A+
Sbjct: 3292 HPCKVNNGGCSNLCLLSP-----GGGHKCACPTNFYLGSDGRTCVSNCTAS 3337
Score = 475 bits (1223), Expect = e-134
Identities = 277/748 (37%), Positives = 382/748 (51%), Gaps = 84/748 (11%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
+C+ EF C + +CI +W CDG +C D SDE+ C TC S F C NRCIP
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCEN--NRCIPN 910
Query: 86 FWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE-AS 142
W CDG DC N DE C +TC ++F C G+CI + CD D DC D SDE AS
Sbjct: 911 RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970
Query: 143 CPVLTCGPAS-FQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFE 201
C TC P + F CN+ CI W CDND DC D SDE G S CS+ +
Sbjct: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE-----------AGCSHSCSSTQ 1019
Query: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEE--NCAVATCRP------DEFQCS-DGNCIHGS 252
F C SG CI W CDG DC D SDE NC RP DEFQC DG CI
Sbjct: 1020 FKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLR 1079
Query: 253 RQCDREYDCKDMSDEVGCVNVT-LCEGPNKFKCH-SGECITLDKVCNMARDCRDWSDE-- 308
+CD + DC D SDE C VT +C+ KF C S CI+ VC+ DC D SDE
Sbjct: 1080 WRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEEN 1139
Query: 309 ----------------------PIKEC-GTNECLD-------------NNGGCSHVCNDL 332
P K C G ++C D NNGGCSH C+
Sbjct: 1140 CESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVA 1199
Query: 333 K-IGYECLCPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTK 390
G C CP G +L C+ C CSQ C + KC C EG+ L+P +
Sbjct: 1200 PGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGE 1259
Query: 391 ACKAVGSIA-YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR 449
+C+++ ++ F+NRHE+R++ L + +Y+ L+P LRN +ALD ++ + +YW+D+ +
Sbjct: 1260 SCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVED 1319
Query: 450 MICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRK 509
I +L ++S++ VI + P+GLAVDWI NIYW +S L + VA G R
Sbjct: 1320 KIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRT 1379
Query: 510 TLFRENGSKPRAIVVDPVHGFMYWTDW-GTPAKIKKGGLNGVDIYSLVTENIQ--WPNGI 566
TL + PRAI +DP G ++WTDW + +I+ ++G ++ E WPNG+
Sbjct: 1380 TLLAGDIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGL 1439
Query: 567 TLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINE 626
T+D L R+ W+D++ +I S +G +L + L+HPF++ ++ +V+WTD
Sbjct: 1440 TVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTN 1499
Query: 627 AIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGG---CQYLCLP 683
+ AN+ TG +V ++ P D+ ++H QP N CE +NGG C +LCL
Sbjct: 1500 TLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCE----ANGGQGPCSHLCL- 1554
Query: 684 APQINPHSPKFTCACPDGMLLARDMRSC 711
IN ++ +CACP M L +D +C
Sbjct: 1555 ---IN-YNRTVSCACPHLMKLHKDNTTC 1578
Score = 461 bits (1187), Expect = e-129
Identities = 270/711 (37%), Positives = 371/711 (52%), Gaps = 60/711 (8%)
Query: 27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
C +EF+C+D G+CI +W CDG +C DGSDE +E C TC+ F C + NRC+P
Sbjct: 3494 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPG 3551
Query: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
W+CD DC + SDE+ C P+ CS+ EF C +G+CI+ ++ CD D DC DGSDE C
Sbjct: 3552 RWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP 3611
Query: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL 205
C FQC S CIP W CD D DC DGSDE + C G V C EF C
Sbjct: 3612 -RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDE--EAC-GTGV-----RTCPLDEFQCN 3662
Query: 206 SGECIHSSWRCDGGPDCKDKSDE--ENCAVATCRPDE-FQC-SDGNCIHGSRQCDREYDC 261
+ C +W+CDG DC D SDE E CA C P+ F+C +D C+ RQCD +C
Sbjct: 3663 NTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNC 3722
Query: 262 KDMSDEVGC----VNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNE 317
D +DE C + T C+ +F C + C++ CNM DC D SDE ++C +
Sbjct: 3723 GDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDP 3780
Query: 318 CLDNNGGCSHVCNDL-------KIGYECLCPDGFQLV-AQRRCEDIDECQDPDTCSQLCV 369
L + + +C D K Y C C GF V Q C+DI+EC TCSQLC
Sbjct: 3781 KLTSCATNASICGDEARCVRTEKAAY-CACRSGFHTVPGQPGCQDINECLRFGTCSQLCN 3839
Query: 370 NLEGGYKCQCEEGFQLDPHTKACKAVGS-IAYLFFTNRHEVRKMTLDR--SEYTSLIPNL 426
N +GG+ C C F +T CKA GS L+ + +E+R + S Y
Sbjct: 3840 NTKGGHLCSCARNFMKTHNT--CKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGD 3897
Query: 427 RNVV--ALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSS---YDTVISRDI-------- 473
+V A+D V + R+YW++ I L A ++ + I R +
Sbjct: 3898 ESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGL 3957
Query: 474 QAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYW 533
+ P G+A+DW+ N+YWTDS + VA KG RKTL +P AIVVDP+ G MYW
Sbjct: 3958 KMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYW 4017
Query: 534 TDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGG 593
+DWG KI+ ++G +LV +NIQWP G+ +D + RLYW D+KL I SI +NG
Sbjct: 4018 SDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGT 4077
Query: 594 NRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMV 653
+ + ++ L+HPFS+ VFED ++ IN +F ++ S + L L D+V
Sbjct: 4078 DPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVV 4137
Query: 654 LFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLL 704
L+H QP N C+R C++LCL ++P P C CP+G L
Sbjct: 4138 LYHQHKQPEVTNPCDRKK-----CEWLCL----LSPSGP--VCTCPNGKRL 4177
Score = 224 bits (570), Expect = 3e-58
Identities = 153/505 (30%), Positives = 236/505 (46%), Gaps = 33/505 (6%)
Query: 232 AVATCRPDEFQCSDG-NCIHGSRQCDREYDCKDMSDEVGCV----NVTLCEGPNKFKCHS 286
A TC P +F C D CI +CD E DC D SDE + C+ PN+ C
Sbjct: 23 APKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQ-PNEHNCLG 81
Query: 287 GE-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ 345
E C+ + ++CN +DC D SDE C + + GC H C G C C FQ
Sbjct: 82 TELCVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQ 140
Query: 346 LVAQ-RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKA----VGSIAY 400
L A + C+D DEC TCSQLC N +G + C C EG+ L P ++CKA V
Sbjct: 141 LQADGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPV 200
Query: 401 LFFTNRHEVRKMTLDRSEYTSLIP-NLRNVVALDTEVASNRIYW-----SDLSQRMICST 454
L N + L ++ +++ P + R A+D A+ + W S ++ C+
Sbjct: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR 260
Query: 455 QLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE 514
V + IS + + +A+DW+ N Y+ D + + V + G TL
Sbjct: 261 MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDL 320
Query: 515 NGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGR 574
P+ I +DP G +++TD+G K+++ ++G + LV I +P+GITLDL+S
Sbjct: 321 ELYNPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRL 380
Query: 575 LYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIIN------EAI 628
+YW D+ L I +D G R+TI++ + H + L VFE+ ++ T+ N ++
Sbjct: 381 VYWADAYLDYIEVVDYEGKGRQTIIQG-ILIEHLYGLTVFENYLYATNSDNANAQQKTSV 439
Query: 629 FSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPR-GVNWCERTTLSN-GGCQYLCLPAPQ 686
NR ++ ++ + + ++H QPR + CE GGC +CL A
Sbjct: 440 IRVNRFNSTEYQVVT-RVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA-- 496
Query: 687 INPHSPKFTCACPDGMLLARDMRSC 711
N H + TC C G L D +SC
Sbjct: 497 -NSHKAR-TCRCRSGFSLGSDGKSC 519
Score = 185 bits (469), Expect = 2e-46
Identities = 101/260 (38%), Positives = 132/260 (50%), Gaps = 23/260 (8%)
Query: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS--CPVLTCGPASFQCNSSTCIP 162
PP C EF C + +CI ++ CD D DCLD SDEA C TC F+C ++ CIP
Sbjct: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIP 909
Query: 163 QLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDC 222
W CD D DC + DE C + C +F C SG CI SW CD DC
Sbjct: 910 NRWLCDGDNDCGNSEDESNATC--------SARTCPPNQFSCASGRCIPISWTCDLDDDC 961
Query: 223 KDKSDEE-NCAVATCRP-DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPN 280
D+SDE +CA TC P +F C++G CI+ + +CD + DC D SDE GC +
Sbjct: 962 GDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSC---SST 1018
Query: 281 KFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLC 340
+FKC+SG CI C+ DC D+SDE C TN+ GGC H ++C
Sbjct: 1019 QFKCNSGRCIPEHWTCDGDNDCGDYSDETHANC-TNQATRPPGGC-HTDE-----FQCRL 1071
Query: 341 PDGFQLVAQRRCEDIDECQD 360
DG + + RC+ +C D
Sbjct: 1072 -DGLCIPLRWRCDGDTDCMD 1090
Score = 185 bits (469), Expect = 2e-46
Identities = 125/397 (31%), Positives = 199/397 (50%), Gaps = 28/397 (7%)
Query: 364 CSQLCV-NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT-S 421
CSQLC+ E C C G+ L +AC+ VGS +L ++ +R + LD ++ + +
Sbjct: 1857 CSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPNDKSDA 1914
Query: 422 LIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
L+P V +D ++ IYW D+ I + D+ + V++ I +G+
Sbjct: 1915 LVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAKRDQTWR----EDVVTNGIGRVEGI 1970
Query: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
AVDWI NIYWTD + VA G R + + KPRAI V P G+++WT+WG
Sbjct: 1971 AVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQY 2030
Query: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV-NGGNRKTI 598
+I++ L+G + LV +I WPNGI++D G+LYW D++ I ID+ G NR+ +
Sbjct: 2031 PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVV 2090
Query: 599 LEDEKRLAHPFSLAVFEDKVFWTD--IINEAIFSANRLTGSDVNLLAENL-LSPEDMVLF 655
L FS++VFED ++W+D N +I ++ +D L + + +D+ +F
Sbjct: 2091 LSSNN--MDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKVF 2148
Query: 656 HNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEA 715
N + +G N C ++NGGCQ LCL + + CAC GM LA D SC A
Sbjct: 2149 -NRDRQKGTNVC---AVANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCREYA 2198
Query: 716 EAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRL 752
+ ++ T + +S R + +P D +
Sbjct: 2199 GYLLYSERTILKSIHLSDE--RNLNAPVQPFEDPEHM 2233
Score = 174 bits (440), Expect = 4e-43
Identities = 124/387 (32%), Positives = 190/387 (49%), Gaps = 37/387 (9%)
Query: 347 VAQRRCEDIDECQDPDTCSQLCV--NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFT 404
V CE+ D+ P CS +C+ N C+C GF L K+CK +L +
Sbjct: 473 VRSHACEN-DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYG 531
Query: 405 NRHE--VRKMTLDRS---EYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRA 459
+R M + E+ I NL N ALD + IY++D + +I ++D
Sbjct: 532 KGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG- 590
Query: 460 HGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDS-VLGTVSVA--DTKGVKRKTLFRENG 516
+ +T++ I +G+AVDW+ N+YWTD T+SVA + RKTL
Sbjct: 591 ---TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKM 647
Query: 517 SKPRAIVVDPVHGFMYWTDWGTPAKIKKGG------LNGV--DIYSLVTENIQWPNGITL 568
+ PRAIVVDP++G+MYWTDW K + G ++G DI+ + ++ + WPNG++L
Sbjct: 648 THPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIF-VTSKTVLWPNGLSL 706
Query: 569 DLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAI 628
D+ +GRLYWVD+ I +I +NG +RK + E + L H F L + +FWT+ + ++
Sbjct: 707 DIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSV 765
Query: 629 FSANRLTGS---DVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAP 685
+ R G V LL ++ ++ Q G N C ++NGGC LCL P
Sbjct: 766 YRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCR---VNNGGCSSLCLATP 822
Query: 686 QINPHSPKFTCACPDGMLLARDMRSCL 712
CAC + +L D +CL
Sbjct: 823 GSR------QCACAEDQVLDADGVTCL 843
Score = 149 bits (376), Expect = 1e-35
Identities = 105/324 (32%), Positives = 146/324 (45%), Gaps = 39/324 (12%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQE-TCLSV--TCKSGD-FSCGGRVNRC 82
C N CQD ++++ + S C+ G + TC +V +C++ D F C C
Sbjct: 2482 CRINNGGCQDLCLLTHQGHVNCS--CRGGRILQDDLTCRAVNSSCRAQDEFECAN--GEC 2537
Query: 83 IPQFWRCDGQVDCDNGSDEQG--CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE 140
I CDG C + SDE+ C + C + +C +G+C+S C+ DC DGSDE
Sbjct: 2538 INFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDE 2597
Query: 141 ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAF 200
C CG F+C TCI C+ DCED SDE C ++ CS++
Sbjct: 2598 IPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDE--MNC--------SATDCSSY 2647
Query: 201 EFHCLSGE----------CIHSSWRCDGGPDCKDKSDEENCAVA---TCRPDEFQCSDGN 247
+ G C SW CDG DC D SDE +C C + F C G
Sbjct: 2648 FRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGR 2707
Query: 248 CIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSD 307
CI S CD+E DC+ DE C N E +F+C + CI+ +C+ + DC D SD
Sbjct: 2708 CIPMSWTCDKEDDCEHGEDETHC-NKFCSEA--QFECQNHRCISKQWLCDGSDDCGDGSD 2764
Query: 308 EPIKECGTNECLDNNGGC--SHVC 329
E C C ++ C +HVC
Sbjct: 2765 E-AAHCEGKTCGPSSFSCPGTHVC 2787
Score = 142 bits (358), Expect = 1e-33
Identities = 95/357 (26%), Positives = 165/357 (46%), Gaps = 28/357 (7%)
Query: 364 CSQLC-VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
CS LC +N C C +L C +L + + E+R + LD Y +
Sbjct: 1549 CSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYNYI 1606
Query: 423 I----PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
I P++ NV LD + R+YWSD+ + I ++ + +TV+S D+ G
Sbjct: 1607 ISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING----TGVETVVSADLPNAHG 1662
Query: 479 LAVDWIHSNIYWT--DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW 536
LAVDW+ N++WT D+ ++VA G + + + +P +VV P+ G +YWTD
Sbjct: 1663 LAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV-QGLEQPHGLVVHPLRGKLYWTDG 1721
Query: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
+ G N ++S + P G+ +D +LYW+ S H+I+ +++G +
Sbjct: 1722 DNISMANMDGSNRTLLFS----GQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLE 1777
Query: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
I +L +LA+ DK++W D ++E + + ++ GS +L + M ++
Sbjct: 1778 VIDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYD 1837
Query: 657 NLTQ--PRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Q +G N C +++NG C LCLP + +C C G L ++C
Sbjct: 1838 ESIQLDHKGTNPC---SVNNGDCSQLCLPTSETTR-----SCMCTAGYSLRSGQQAC 1886
Score = 142 bits (358), Expect = 1e-33
Identities = 103/330 (31%), Positives = 139/330 (42%), Gaps = 62/330 (18%)
Query: 98 GSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDR------------DCLDGSDE-ASCP 144
G + CP + R C + QFVC +D+ DC D SDE CP
Sbjct: 3311 GGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCP 3370
Query: 145 VLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC 204
C P FQC++ C + CD D DC+D SDE C D C +F C
Sbjct: 3371 EFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDE--ANC--------DIHVCLPSQFKC 3420
Query: 205 L-SGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCS-DGNCIHGSRQCDREYDCK 262
+ CI +RC+G +C D DE +C TC P++FQCS CI CDR+ DC
Sbjct: 3421 TNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCV 3480
Query: 263 DMSDE-VGCVNVTLCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDEPIKECGTNECLD 320
D SDE C +T G ++F+C SG CI C+ DC D SDEP +EC C
Sbjct: 3481 DGSDEPANCTQMTC--GVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEP 3538
Query: 321 NNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD--------PDTCSQ---LCV 369
Y+ C + + + +C+ ++C D P CS+ C
Sbjct: 3539 ---------------YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCA 3583
Query: 370 N---LEGGYKC----QCEEGFQLDPHTKAC 392
N + G +KC C +G T C
Sbjct: 3584 NGRCIAGRWKCDGDHDCADGSDEKDCTPRC 3613
Score = 136 bits (343), Expect = 7e-32
Identities = 107/389 (27%), Positives = 185/389 (47%), Gaps = 47/389 (12%)
Query: 364 CSQLCVNLEGGYK-CQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTL--DRSEYT 420
C QLC+ G + C C G + + G YL ++ R ++ + L +R+
Sbjct: 2166 CQQLCLYRGRGQRACACAHGMLAEDGASCREYAG---YLLYSERTILKSIHLSDERNLNA 2222
Query: 421 SLIP-----NLRNVVALDTEVAS-------NRIYWSDLSQRMICSTQLDRAHGVSSYDTV 468
+ P +++NV+AL + + NRI++SD+ I D + ++
Sbjct: 2223 PVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRIT----- 2277
Query: 469 ISRDIQAPDGLAVDWIHSNIYWTDSVLGTVS---VADTK--GVKRKTLFRENGSK-PRAI 522
I ++ + +GLA +YWT T++ V T+ +R+T+ +G PRA
Sbjct: 2278 IVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAF 2337
Query: 523 VVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSK 581
V+D M+WT+W I + L+G ++ +L+ ++I+ PNG+ +D + +LY+ D+
Sbjct: 2338 VLDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDAT 2397
Query: 582 LHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNL 641
L I + +G +R IL+ E HPF LAV+ + +FWTD + A+ AN+ GS++ L
Sbjct: 2398 LDKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKL 2455
Query: 642 LAENL-LSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
L ++ P ++ N T ++ C ++NGGCQ LCL H C+C
Sbjct: 2456 LRVDIPQQPMGIIAVANDTNSCELSPCR---INNGGCQDLCLLT-----HQGHVNCSCRG 2507
Query: 701 GMLLARDM------RSCLTEAEAAVATQE 723
G +L D+ SC + E A E
Sbjct: 2508 GRILQDDLTCRAVNSSCRAQDEFECANGE 2536
Score = 114 bits (286), Expect = 3e-25
Identities = 79/237 (33%), Positives = 106/237 (44%), Gaps = 42/237 (17%)
Query: 18 AAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGG 77
AAG C+ EF CQ+ +CI +VCD +C DGSDES E C TC +F C
Sbjct: 2809 AAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPE-CEYPTCGPSEFRCAN 2867
Query: 78 RVNRCI-PQFWRCDGQVDCDNGSDEQGCPPKTCSQD-------EFRCHDGKCISRQFVCD 129
RC+ + W CDG+ DC + SDE P SQ+ +F C G+C++ +C+
Sbjct: 2868 --GRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCN 2925
Query: 130 SDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYV 189
DC D SDE C + C +L C DCED + RCR +
Sbjct: 2926 GQDDCGDSSDERGCHINEC-----------LSRKLSGCSQ--DCEDLKIGFKCRCRPGFR 2972
Query: 190 FQGDSSPCSAFE-----FHCLSGECI--HSSWRC---------DGGP-DCKDKSDEE 229
+ D C+ + F C S CI H S++C G P CK +DEE
Sbjct: 2973 LKDDGRTCADVDECSTTFPC-SQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEE 3028
Score = 111 bits (277), Expect = 3e-24
Identities = 61/168 (36%), Positives = 79/168 (47%), Gaps = 20/168 (11%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
RC+ ++FQC+ G CI +W CD A+C DGSDE TC +F C + C P
Sbjct: 3612 RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTL--CKPL 3669
Query: 86 FWRCDGQVDCDNGSDEQG-------CPPKTCSQDEFRC-HDGKCISRQFVCDSDRDCLDG 137
W+CDG+ DC + SDE CPP FRC +D C+ CD +C DG
Sbjct: 3670 AWKCDGEDDCGDNSDENPEECARFVCPPNR----PFRCKNDRVCLWIGRQCDGTDNCGDG 3725
Query: 138 SDEASCPVLTC------GPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
+DE C T F C + C+ C+ DC DGSDE
Sbjct: 3726 TDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE 3773
Score = 108 bits (270), Expect = 2e-23
Identities = 78/275 (28%), Positives = 111/275 (40%), Gaps = 49/275 (17%)
Query: 116 CHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCED 175
C G+ + C + DE F+C + CI CD P C+D
Sbjct: 2505 CRGGRILQDDLTCRAVNSSCRAQDE------------FECANGECINFSLTCDGVPHCKD 2552
Query: 176 GSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVAT 235
SDE P C +S C C +G C+ + C+G DC D SDE C
Sbjct: 2553 KSDEKPSYC--------NSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA 2604
Query: 236 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKC---------HS 286
C EF+C DG CI S +C++ DC+D SDE+ C + T C + +
Sbjct: 2605 CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC-SATDCSSYFRLGVKGVLFQPCERT 2663
Query: 287 GECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL 346
C VC+ A DC D+SDE ++C G C + Y CP G +
Sbjct: 2664 SLCYAPSWVCDGANDCGDYSDE--RDC--------PGVKRPRC---PLNY-FACPSGRCI 2709
Query: 347 VAQRRCEDIDEC---QDPDTCSQLCVNLEGGYKCQ 378
C+ D+C +D C++ C E ++CQ
Sbjct: 2710 PMSWTCDKEDDCEHGEDETHCNKFC--SEAQFECQ 2742
Score = 77.0 bits (188), Expect = 7e-14
Identities = 59/184 (32%), Positives = 73/184 (39%), Gaps = 29/184 (15%)
Query: 106 PKTCSQDEFRCHDG-KCISRQFVCDSDRDCLDGSDEAS--CP---VLTCGPASFQC-NSS 158
PKTCS +F C D CIS+ + CD +RDC DGSDEA CP C P C +
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 159 TCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDG 218
C+P C+ DC DGSDE P C + +C C H
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDEGPH--------------CRELQGNCSRLGCQHHCVPTLD 129
Query: 219 GPDCKDKSDEENCAVATCRPDEFQCS-DGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCE 277
GP C S + A D +CS G C D + C GCV L +
Sbjct: 130 GPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFIC-------GCVEGYLLQ 182
Query: 278 GPNK 281
N+
Sbjct: 183 PDNR 186
Score = 65.9 bits (159), Expect = 2e-10
Identities = 35/90 (38%), Positives = 46/90 (51%), Gaps = 5/90 (5%)
Query: 16 LAAAGTAVGDRCERNEFQCQDG-KCISYKWVCDGSAECQDGSDESQETC---LSVTCKSG 71
L AA C +F C+D CIS W CDG +C DGSDE+ E C + C+
Sbjct: 16 LVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPN 75
Query: 72 DFSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
+ +C G C+P C+G DC +GSDE
Sbjct: 76 EHNCLG-TELCVPMSRLCNGVQDCMDGSDE 104
Score = 34.7 bits (78), Expect = 0.39
Identities = 14/36 (38%), Positives = 20/36 (55%)
Query: 307 DEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
D ++ GTN+C NNGGCS +C +C C +
Sbjct: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACAE 831
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 492 bits (1266), Expect = e-139
Identities = 276/751 (36%), Positives = 390/751 (51%), Gaps = 78/751 (10%)
Query: 20 GTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRV 79
G A+ C+ EF+C++ CI +W CDG +C DGSDE C + +C F C +
Sbjct: 838 GEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC--QN 895
Query: 80 NRCIPQFWRCDGQVDCDNGSDE--QGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
NRCIP+ W CDG DC + DE Q C +TC D+F C +G+CI R ++CD + DC D
Sbjct: 896 NRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQ 955
Query: 138 SDE-ASCPVLTCGP-ASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
+DE ASC TC P F C S CI W CD+D DC DGSDE G
Sbjct: 956 TDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDE-----------VGCVH 1004
Query: 196 PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEE--NC------AVATCRPDEFQC-SDG 246
C +F C SG CI W CDG DC D SDE NC + A C +EFQC DG
Sbjct: 1005 SCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDG 1064
Query: 247 NCIHGSRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHS-GECITLDKVCNMARDCRD 304
NC+ +CD E DC+D SDE GC + LC+ KF C S G CI VC+ DC D
Sbjct: 1065 NCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
Query: 305 WSDE------------------------PIKECG--------------TNECLDNNGGCS 326
SDE P K C +EC NNGGCS
Sbjct: 1125 QSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGCS 1184
Query: 327 HVCNDLK-IGYECLCPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQ 384
+ C+ + G C CP+G QL + CE +D C + CSQ+C + KC C EG++
Sbjct: 1185 NHCSVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWK 1244
Query: 385 LDPHTKACKAVGSI-AYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYW 443
LD ++C +V A++ F+ RHE+R++ L + +Y+ L+P LRN +ALD + +YW
Sbjct: 1245 LDVDGESCTSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYW 1304
Query: 444 SDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADT 503
+D+ + I +L + GVS+ + V+ + P+GL VDWI NIYW DS L + VA
Sbjct: 1305 TDVVEDRIYRGKLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKL 1364
Query: 504 KGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTE--NI 560
G R TL PRAI +DP +G ++WTDW +I+ ++G ++ +
Sbjct: 1365 DGSLRTTLIAGAMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYKDMKTG 1424
Query: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
WPNG+T+D R+ W D++ +I S +G N I+ + L+HPF+++++ +V+W
Sbjct: 1425 AWPNGLTVDHFEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYW 1484
Query: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680
TD + AN+ TG +V+++ + P D+ ++H QP+ N C G C ++
Sbjct: 1485 TDWRTNTLSKANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAAND-GKGPCSHM 1543
Query: 681 CLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
CL IN H+ CACP M L+ D ++C
Sbjct: 1544 CL----IN-HNRSAACACPHLMKLSSDKKTC 1569
Score = 419 bits (1078), Expect = e-117
Identities = 242/696 (34%), Positives = 359/696 (51%), Gaps = 43/696 (6%)
Query: 39 CISYKWVCDGSAECQDGSDESQETCLSV-TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDN 97
C+ W+CDGS +C D SDE + + C+ FSC RCI W CDGQ DC++
Sbjct: 2652 CVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPS--GRCILNTWICDGQKDCED 2709
Query: 98 GSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS--CPVLTCGPASFQC 155
G DE C +CS ++F C KCIS+ ++CD + DC DG DE+ C +TC F C
Sbjct: 2710 GRDEFHCD-SSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSC 2768
Query: 156 NSS-TCIPQLWACDNDPDCEDGSDEWPQR-CRGLYVFQGDSSPCSAFEFHCLSGECIHSS 213
S C+P+ W CD + DC DGSDE C ++ C F C + CI
Sbjct: 2769 QGSRACVPRHWLCDGERDCPDGSDELSTAGC-------APNNTCDENAFMCHNKVCIPKQ 2821
Query: 214 WRCDGGPDCKDKSDEE-NCAVATCRPDEFQCSDGNCIHGSR-QCDREYDCKDMSDEVG-- 269
+ CD DC D SDE C C +EF C+DG C+ ++ QCD ++DC D SDE
Sbjct: 2822 FVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLN 2881
Query: 270 --CVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNN-GGCS 326
C + + F C +G CI +C+ DC D SDE + C NECL GCS
Sbjct: 2882 PKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCS 2939
Query: 327 HVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQL 385
C DL + Y+C C GFQL + C DIDEC CSQ C+N G YKC C +G+++
Sbjct: 2940 QDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEI 2999
Query: 386 DP-HTKACKAVGSIA-YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYW 443
P + CK++ +L + HE+RK++ D S YT L L NV+A+D + IYW
Sbjct: 3000 QPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYW 3059
Query: 444 SDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADT 503
D S+ ++++R ++ D + + P+ LAVDWI N+YW+D+ + V+
Sbjct: 3060 IDSSRPN--GSRINRMC-LNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKL 3116
Query: 504 KGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWP 563
G+ L + PR + +DP G++YW D I + G++G + ++ I P
Sbjct: 3117 NGLYPTILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRP 3176
Query: 564 NGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDI 623
+T+D ++ RLYW D S++D G +R + + + +L +FED ++WTD
Sbjct: 3177 MALTIDYVNRRLYWADENHIEFSNMD--GSHRHKVPNQD--IPGVIALTLFEDYIYWTDG 3232
Query: 624 INEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPR-GVNWCERTTLSNGGCQYLCL 682
+++ A++ +G+D L + + D+ ++H+ QP + C ++NGGC +LCL
Sbjct: 3233 KTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLC---MINNGGCSHLCL 3289
Query: 683 PAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
AP TCACP LA D R+CL+ A+
Sbjct: 3290 LAP-----GKTHTCACPTNFYLAADNRTCLSNCTAS 3320
Score = 365 bits (938), Expect = e-101
Identities = 249/789 (31%), Positives = 345/789 (43%), Gaps = 133/789 (16%)
Query: 27 CERNEFQCQDGK-CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
C + FQC+ K CIS WVCD +C D SDE+ C TC +F C + N CIP
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEAN--CDKKTCGPHEFQC--KNNNCIPD 3491
Query: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
WRCD Q DC + SDE+ C P+TC+ +F C +G C+S +F CD D DC DGSDE +C
Sbjct: 3492 HWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCET 3551
Query: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWP------------------------ 181
+C F+C++ CIP W CD DC+ G DE
Sbjct: 3552 -SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISAS 3610
Query: 182 QRCRGLYVFQGDS------SPCSAFEFHCLS-GECIHSSWRCDGGPDCKDKSDEENCAVA 234
+C G Y S + C +F C + CI W CDG DC D SDEENC
Sbjct: 3611 LKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERG 3670
Query: 235 --TCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVG--CVNVT---------------- 274
CR DEF C++ C CD E DC D SDE CV
Sbjct: 3671 GNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICL 3730
Query: 275 ----LCEG-------------------------PNKFKCHSGECITLDKVCNMARDCRDW 305
+C G ++F C + +CI +D C+ DC D
Sbjct: 3731 QSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDG 3790
Query: 306 SDEPIKECGTNE--CLDNNGGCSH--VCNDLKIGYECLCPDGFQL-VAQRRCEDIDECQD 360
SDE E C DN C CN +K C C GFQ + R+CED++EC
Sbjct: 3791 SDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLV 3850
Query: 361 PDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSI-AYLFFTNRHEVRKMTL----- 414
TCS C+N+EG YKC C++ FQ +T C A GS L+ N ++
Sbjct: 3851 FGTCSHQCINVEGSYKCVCDQNFQERNNT--CIAEGSEDQVLYIANDTDILGFIYPFNYS 3908
Query: 415 -DRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDT---VIS 470
D + + + N R + +D + I WS +Q R HG +I
Sbjct: 3909 GDHQQISHIEHNSR-ITGMDVYYQRDMIIWS--TQFNPGGIFYKRIHGREKRQANSGLIC 3965
Query: 471 RDIQAPDGLAVDWIHSNIYWTD---------------SVLGTVSVADTKGVKRKTLFREN 515
+ + P +AVDW+ NIYWTD S+ +++V G L
Sbjct: 3966 PEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNM 4025
Query: 516 GSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
+P AI V+P G MYWT G + I++ ++G LV +N+Q P G+ +D S R+
Sbjct: 4026 AGEPYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERI 4085
Query: 576 YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT 635
YW D +L I S+ +G N + ++ L HP + +FED ++ N +F +
Sbjct: 4086 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKN-GVFRVQKFG 4144
Query: 636 GSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFT 695
V LA N+ + +++ H Q N C + C++LCL +NP T
Sbjct: 4145 HGSVEYLALNIDKTKGVLISHRYKQLDLPNPC-----LDLACEFLCL----LNPSGA--T 4193
Query: 696 CACPDGMLL 704
C CP+G L
Sbjct: 4194 CVCPEGKYL 4202
Score = 244 bits (623), Expect = 2e-64
Identities = 219/802 (27%), Positives = 332/802 (41%), Gaps = 192/802 (23%)
Query: 16 LAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSC 75
LAA C ++F+C+ KCI + W CD +C DGSDE + C C+ G F C
Sbjct: 3306 LAADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDD-CPEFRCQPGRFQC 3364
Query: 76 G--------------------------------------GRVNRCIPQFWRCDGQVDCDN 97
G + +CIP RC+GQ DC +
Sbjct: 3365 GTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGD 3424
Query: 98 GSDEQGCPPKTCSQDEFRCHDGK-CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN 156
DE+ CP +CS D F+C K CIS+ +VCD D DC D SDEA+C TCGP FQC
Sbjct: 3425 EEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCK 3484
Query: 157 SSTCIPQLWACDNDPDCEDGSDE---WPQRC--RGLYVFQGD------------------ 193
++ CIP W CD+ DC D SDE PQ C + GD
Sbjct: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
Query: 194 -----SSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC--AVATCRPDEFQCSDG 246
+ CS +F C +G+CI + W+CDG DCK DE++C A TC E+ C+
Sbjct: 3545 DERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASD 3604
Query: 247 NCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKC-HSGECITLDKVCNMARDCRDW 305
CI S +C+ EYDC D SDE+ C VT C+ ++F+C + CI + +C+ DC D
Sbjct: 3605 GCISASLKCNGEYDCADGSDEMDC--VTECK-EDQFRCKNKAHCIPIRWLCDGIHDCVDG 3661
Query: 306 SDEPIKECGTNEC-----LDNNGGCS---HVCN-------------DLKIGYECLCP--- 341
SDE E G N C L NN C VC+ D+ + + LCP
Sbjct: 3662 SDEENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKF--LCPSTR 3719
Query: 342 ------DGFQLVAQRRCEDIDEC---QDPDTC-------SQLCVNLE---GGYKC----- 377
+ L +++ C IDEC D D C ++ C E KC
Sbjct: 3720 PHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDL 3779
Query: 378 QC-----------EEGFQLDPHTKACK----AVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
QC E+G ++ P C+ G AY ++++ R +
Sbjct: 3780 QCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYC-----NQIKTSVFCRCK-PGF 3833
Query: 423 IPNLRNVVALDTEVASNRIYWSDLSQRMI---CSTQLDRAHGVSSYDTVISRDIQAPDGL 479
N++N DL++ ++ CS Q G SY V ++ Q +
Sbjct: 3834 QRNMKNRQC------------EDLNECLVFGTCSHQCINVEG--SYKCVCDQNFQERNNT 3879
Query: 480 AV-----DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT 534
+ D + TD +LG + + G ++ E+ S+ + V + W+
Sbjct: 3880 CIAEGSEDQVLYIANDTD-ILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWS 3938
Query: 535 DWGTPAKIKKGGLNGVD----IYSLVTENIQWPNGITLDLLSGRLYWVD-SKLH------ 583
P I ++G + L+ + P I +D ++G +YW D S++H
Sbjct: 3939 TQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYT 3998
Query: 584 --------SISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDK--VFWTDIINEAIFSANR 633
SI+ +NG N +L + P+++AV + ++WT + + +
Sbjct: 3999 THWTSLRYSINVGQLNGPNCTRLLTN--MAGEPYAIAVNPKRGMMYWTVVGDHSHIEEAA 4056
Query: 634 LTGSDVNLLAE-NLLSPEDMVL 654
+ G+ +L + NL P + +
Sbjct: 4057 MDGTLRRILVQKNLQRPTGLAV 4078
Score = 216 bits (550), Expect = 7e-56
Identities = 147/498 (29%), Positives = 235/498 (47%), Gaps = 35/498 (7%)
Query: 236 CRPDEFQCSDG-NCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCH--------S 286
C P EF C D C+ S CD + DC D SDE ++ C + KC +
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE----SLDTCPEEVEIKCPLNHIACLGT 87
Query: 287 GECITLDKVCNMARDCRDWSDEPIKECGTNECLDN--NGGCSHVCNDLKIGYECLCPDGF 344
+C+ L ++CN DC D DE + E L N C + C ++ C C DGF
Sbjct: 88 NKCVHLSQLCNGVLDCPDGYDEGVH---CQELLSNCQQLNCQYKCTMVRNSTRCYCEDGF 144
Query: 345 QLVAQ-RRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKA----VGSIA 399
++ R C+D DEC TCSQ C N G Y C C EG+ + P ++CKA
Sbjct: 145 EITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPP 204
Query: 400 YLFFTNRHEVRKMTLDRSEYTSLIP-NLRNVVALDTEVASNRIYW--SDLSQRMICSTQL 456
L N + L+ S+ +L N + LD + I W S S + Q+
Sbjct: 205 ILLIANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQI 264
Query: 457 DRAHGVSSYDTV-ISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFREN 515
+A G++ T+ I + +A+DW+ N+Y+ D V + V ++ G TL
Sbjct: 265 TKAGGLTDEWTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLE 324
Query: 516 GSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL 575
P+AI VDP+ G +++TD+G AK+++ ++G++ ++ + P + LDL++ +
Sbjct: 325 LHNPKAIAVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLV 384
Query: 576 YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLT 635
YWVD L + +D G NR T+++ +++ H + + VFED ++ T+ N I NR
Sbjct: 385 YWVDLYLDYVGVVDYQGKNRHTVIQG-RQVRHLYGITVFEDYLYATNSDNYNIVRINRFN 443
Query: 636 GSDVNLLAENLLSPEDMVLFHNLTQPR-GVNWCERTTLS-NGGCQYLCLPAPQINPHSPK 693
G+D++ L + + + + ++ TQP + CE GGC ++CL +
Sbjct: 444 GTDIHSLIK-IENAWGIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTR--- 499
Query: 694 FTCACPDGMLLARDMRSC 711
TC C G L D RSC
Sbjct: 500 -TCRCRTGFNLGSDGRSC 516
Score = 197 bits (500), Expect = 5e-50
Identities = 134/382 (35%), Positives = 196/382 (51%), Gaps = 35/382 (9%)
Query: 347 VAQRRCEDIDECQDPDTCSQLCVNLEGGYK---CQCEEGFQLDPHTKACKAVGSIAYLFF 403
V CE +D P CS +C+ L YK C+C GF L ++CK + +LF+
Sbjct: 470 VRSHACE-VDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFY 527
Query: 404 TNRHE--VRKMTLDRS---EYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDR 458
VR M L+ EY I NL N ALD +N IY++D + +I ++D
Sbjct: 528 GKGRPGIVRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG 587
Query: 459 AHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT-DSVLGTVSVA--DTKGVKRKTLFREN 515
+ +T++ D+ +G+AVDWI +N+YWT D T++VA + RKTL
Sbjct: 588 ----TERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE 643
Query: 516 GSKPRAIVVDPVHGFMYWTDW------GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 569
S PR IVVDPV+G+MYWTDW + +I+K ++G + VT + WPNG+TLD
Sbjct: 644 MSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLD 703
Query: 570 LLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF 629
+ LYW D+ I + +NG +RK I+ + L HPF L+ + VFWTD +N +IF
Sbjct: 704 FHTNTLYWCDAYYDHIEKVFLNGTHRK-IVYSGRELNHPFGLSHHGNYVFWTDYMNGSIF 762
Query: 630 SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINP 689
+ +T S+V LL P + ++ + +G N C ++NGGC LCL P
Sbjct: 763 QLDLIT-SEVTLLRHE-RPPLFGLQIYDPRKQQGDNMCR---VNNGGCSTLCLAIPGGR- 816
Query: 690 HSPKFTCACPDGMLLARDMRSC 711
CAC D LL + +C
Sbjct: 817 -----VCACADNQLLDENGTTC 833
Score = 169 bits (427), Expect = 1e-41
Identities = 122/425 (28%), Positives = 199/425 (46%), Gaps = 50/425 (11%)
Query: 305 WSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDT 363
W+D+ + + GT C +G + + G + ++ + + + CQ +
Sbjct: 1792 WADQNLAQLGT--CSKRDGRNPTILRNKTSGVVHM-----KVYDKEAQQGSNSCQLNNGG 1844
Query: 364 CSQLCV-NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
CSQLC+ E C C G+ L + +C+ + S +L ++ +R + L+ S+
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGIES--FLMYSVHEGIRGIPLEPSDKMDA 1902
Query: 423 IPNLRNV---VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGL 479
+ + V +D ++ IYW+D+ I + D+ + +I+ + +G+
Sbjct: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWK----EDIITNGLGRVEGI 1958
Query: 480 AVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP 539
AVDWI NIYWTD + VA G R + + +PR+I V P G ++WT+WG
Sbjct: 1959 AVDWIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQM 2018
Query: 540 AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDV-NGGNRKTI 598
I K L+G + LV+ I WPNGI++D +LYW D++ I ID+ GGNR+ +
Sbjct: 2019 PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMV 2078
Query: 599 LEDEKRLAHPFSLAVFEDKVFWTDII-----------NEAIFSANRLTGSDVNLLAENLL 647
L FS+AVF ++W+D N+A + TG VNL
Sbjct: 2079 LSGSN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNL------ 2130
Query: 648 SPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARD 707
+++ +F N + +G N C R NGGC+ LCL + + TCAC G LA D
Sbjct: 2131 --KEVKIF-NRVREKGTNVCAR---DNGGCKQLCL-----YRGNSRRTCACAHG-YLAED 2178
Query: 708 MRSCL 712
+CL
Sbjct: 2179 GVTCL 2183
Score = 154 bits (388), Expect = 4e-37
Identities = 98/355 (27%), Positives = 169/355 (47%), Gaps = 27/355 (7%)
Query: 364 CSQLC-VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL 422
CS +C +N C C +L K C + +L + R E+R + +D + +
Sbjct: 1540 CSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFNFI 1597
Query: 423 ----IPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
+P++ +V +D + + R+YW+D+ + I ++ + +TVISRDIQ+ G
Sbjct: 1598 TAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING----TGLETVISRDIQSIRG 1653
Query: 479 LAVDWIHSNIYWTDSVLGT--VSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW 536
LAVDW+ N+YW S ++VA G KT KP+ + PV G +YWTD
Sbjct: 1654 LAVDWVSRNLYWISSEFDETQINVARLDG-SLKTSIIHGIDKPQCLAAHPVRGKLYWTDG 1712
Query: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
T G N ++ +N + P G+++D + +LYW+ S +I+ +++GGN +
Sbjct: 1713 NTINMANMDGSNS----KILFQNQKEPVGLSIDYVENKLYWISSGNGTINRCNLDGGNLE 1768
Query: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
I ++ L +L + + K++W D + + ++ G + +L M ++
Sbjct: 1769 VIESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYD 1828
Query: 657 NLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
Q +G N C+ L+NGGC LCLP + TC C G L ++ SC
Sbjct: 1829 KEAQ-QGSNSCQ---LNNGGCSQLCLPTSETTR-----TCMCTVGYYLQKNRMSC 1874
Score = 113 bits (282), Expect = 9e-25
Identities = 100/391 (25%), Positives = 170/391 (43%), Gaps = 50/391 (12%)
Query: 359 QDPDTCSQLCVNLEGGYK-CQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRS 417
+D C QLC+ + C C G+ + + G YL ++ R ++ + L S
Sbjct: 2149 RDNGGCKQLCLYRGNSRRTCACAHGYLAEDGVTCLRHEG---YLLYSGRTILKSIHL--S 2203
Query: 418 EYTSLIPNLR---------NVVALDTEV-----ASNRIYWSDL---SQRMICSTQLDRAH 460
+ T+L +R NV+AL + +NRI++SD + ++I DR
Sbjct: 2204 DETNLNSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQ- 2262
Query: 461 GVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRE------ 514
VI ++ + +GLA +YWT S +++ + RE
Sbjct: 2263 -------VIVENVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMS 2315
Query: 515 NGSKPRAIVVDPVHGFMYWTDWGTP-AKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSG 573
P + +D M+WT+W I + L G + +V+ +I PNG+T+D +
Sbjct: 2316 EDDHPHVLALDECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAE 2375
Query: 574 RLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANR 633
+LY+ D L I + +G R I++ SLAV+++ +FW+D AI +N+
Sbjct: 2376 KLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTF--LSLAVYDNYIFWSDWGRRAILRSNK 2433
Query: 634 LTGSDVNLLAENL-LSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSP 692
TG D +L ++ P ++ N T ++ C L NGGC LCL P +
Sbjct: 2434 YTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPC---ALLNGGCHDLCLLTP-----NG 2485
Query: 693 KFTCACPDGMLLARDMRSCLTEAEAAVATQE 723
+ C+C +L D R C+T+ + A E
Sbjct: 2486 RVNCSCRGDRILLEDNR-CVTKNSSCNAYSE 2515
Score = 112 bits (280), Expect = 1e-24
Identities = 76/238 (31%), Positives = 108/238 (45%), Gaps = 41/238 (17%)
Query: 16 LAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSC 75
L+ AG A + C+ N F C + CI ++VCD +C DGSDES + C C + +FSC
Sbjct: 2794 LSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQ-CGYRQCGTEEFSC 2852
Query: 76 GGRVNRCIPQF-WRCDGQVDCDNGSDEQGCPPK------TCSQDEFRCHDGKCISRQFVC 128
RC+ W+CDG DC + SDE PK +C+ F C +G+CI +C
Sbjct: 2853 AD--GRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLC 2910
Query: 129 DSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLY 188
D+ DC DGSDE +C + C S C DC+D + +C +
Sbjct: 2911 DNKDDCGDGSDERNCHINEC----LSKKVSGC---------SQDCQDLPVSYKCKCWPGF 2957
Query: 189 VFQGDSSPCSAFEFHCLSG-----ECI--HSSWRC----------DGGPDCKDKSDEE 229
+ D C + C SG +CI + +++C D CK SDEE
Sbjct: 2958 QLKDDGKTCVDID-ECSSGFPCSQQCINTYGTYKCLCTDGYEIQPDNPNGCKSLSDEE 3014
Score = 111 bits (278), Expect = 3e-24
Identities = 91/321 (28%), Positives = 131/321 (40%), Gaps = 70/321 (21%)
Query: 108 TCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWAC 167
+C D D +C+++ C++ + F+C + CI C
Sbjct: 2490 SCRGDRILLEDNRCVTKNSSCNAYSE-------------------FECGNGECIDYQLTC 2530
Query: 168 DNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSD 227
D P C+D SDE C ++ C C + CI CDG DC D SD
Sbjct: 2531 DGIPHCKDKSDEKLLYC--------ENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSD 2582
Query: 228 EENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNK------ 281
E +C V+TC EF+C+DG CI S +C++ DC D SDE C N T C K
Sbjct: 2583 ELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDEKNC-NNTDCTHFYKLGVKTT 2641
Query: 282 --FKCHSGE-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYEC 338
+C+S C+ +C+ + DC D+SDE +C N H C +
Sbjct: 2642 GFIRCNSTSLCVLPTWICDGSNDCGDYSDE-------LKCPVQN---KHKCEENYFS--- 2688
Query: 339 LCPDGFQLV------AQRRCED-IDECQDPDTCS--------QLCVNLEGGYKCQCEE-- 381
CP G ++ Q+ CED DE +CS Q C++ + C E+
Sbjct: 2689 -CPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKH--WICDGEDDC 2745
Query: 382 GFQLDPHTKACKAVGSIAYLF 402
G LD C A+ A +F
Sbjct: 2746 GDGLDESDSICGAITCAADMF 2766
Score = 67.8 bits (164), Expect = 4e-11
Identities = 46/165 (27%), Positives = 69/165 (41%), Gaps = 27/165 (16%)
Query: 12 VALLLAAAGTAVGDRCERNEFQCQDG-KCISYKWVCDGSAECQDGSDESQETC---LSVT 67
+A +L C+ EF C D C+S W+CDG +C D SDES +TC + +
Sbjct: 17 IARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK 76
Query: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDE--------QGCPPKTCS------QDE 113
C +C G N+C+ C+G +DC +G DE C C ++
Sbjct: 77 CPLNHIACLG-TNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNS 135
Query: 114 FRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSS 158
RC+ C + + R C D+ C V G S C ++
Sbjct: 136 TRCY---CEDGFEITEDGRSC---KDQDECAVY--GTCSQTCRNT 172
Score = 37.0 bits (84), Expect = 0.078
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 308 EPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
+P K+ G N C NNGGCS +C + G C C D
Sbjct: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACAD 822
Score = 33.9 bits (76), Expect = 0.66
Identities = 29/106 (27%), Positives = 46/106 (43%), Gaps = 8/106 (7%)
Query: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGY 336
+G N + ++G C TL R C ++ + E GT + H+C K G
Sbjct: 793 QGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHIC---KAG- 848
Query: 337 ECLCPDGFQLVAQRRCEDIDECQD-PDTCSQLCVN---LEGGYKCQ 378
E C + + A+ +C+ D+C D D S C N + +KCQ
Sbjct: 849 EFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQ 894
Score = 32.0 bits (71), Expect = 2.5
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 12/71 (16%)
Query: 316 NECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLC------- 368
N CLD C +C G C+CP+G L+ C D D D D+C C
Sbjct: 4174 NPCLDL--ACEFLCLLNPSGATCVCPEGKYLI-NGTCND-DSLLD-DSCKLTCENGGRCI 4228
Query: 369 VNLEGGYKCQC 379
+N +G +C C
Sbjct: 4229 LNEKGDLRCHC 4239
Score = 32.0 bits (71), Expect = 2.5
Identities = 27/83 (32%), Positives = 36/83 (43%), Gaps = 11/83 (13%)
Query: 96 DNGSDEQGCPPK----TCSQDE-FRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGP 150
D+GS E CP + C D+ RCH G CI + D +C +G +SC +
Sbjct: 4339 DDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSCQLCD--- 4395
Query: 151 ASFQCNSSTCIPQLWACDNDPDC 173
+ N TC QL N P C
Sbjct: 4396 -GYCYNGGTC--QLDPETNVPVC 4415
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 487 bits (1253), Expect = e-137
Identities = 265/704 (37%), Positives = 376/704 (53%), Gaps = 60/704 (8%)
Query: 27 CERNEFQCQDGK-CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
C+ +C + CI ++CDG +C D SDE+ C + TC S +F C RCIPQ
Sbjct: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCAS--GRCIPQ 2879
Query: 86 FWRCDGQVDCDNGSDEQ---GCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEAS 142
W CD + DC + SDE G +TC DEF+C G+CI +++CD D DC D SDE
Sbjct: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDK 2939
Query: 143 ---CPVLTCGPASFQCNSST-----CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDS 194
C C + F C + CIPQ W CD D DC DG DE Q C
Sbjct: 2940 RHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDE-NQNCT--------R 2990
Query: 195 SPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQ 254
CS EF C G CI +RCD DC D SDE C TC+ ++F C +G CI +
Sbjct: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
Query: 255 CDREYDCKDMSDEVGCVNVTLCEGP------NKFKCHSGECITLDKVCNMARDCRDWSDE 308
CD + DC D SDE+ + LC P ++FKC +G CI + K+CN DC D SDE
Sbjct: 3051 CDEDNDCGDGSDEL----MHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
Query: 309 PIKECGTNECLDNN-GGCSHVCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-PDTCS 365
K CG NEC D + GC H C D + C C G++L++ +R C DIDEC + P CS
Sbjct: 3107 --KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCS 3164
Query: 366 QLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIA-YLFFTNRHEVRKMTLDRSEYTSLIP 424
Q C N+ G Y C+C G+ +P K C+ +I YL F+NR+ +R +T+D Y+ ++
Sbjct: 3165 QKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILE 3224
Query: 425 NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWI 484
L NVVALD + R+YW D +++I L++ ++ +T+I+ + A + LAVDW+
Sbjct: 3225 GLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNK----TNKETIINHRLPAAESLAVDWV 3280
Query: 485 HSNIYWTDSVLGTVSVADTKGVKRKTLFRE----NGS----KPRAIVVDPVHGFMYWTDW 536
+YW D+ L + V+D G R+ L + N + PR + + P +G++YW DW
Sbjct: 3281 SRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADW 3340
Query: 537 GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRK 596
G A I + G++G + +++ ++WPNGIT+D + LYW D+ L I D+ G +R
Sbjct: 3341 GHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRH 3400
Query: 597 TILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFH 656
T+ + L HPF++ +FED ++WTD + N+ GS+ L P D+ ++H
Sbjct: 3401 TVYDG--ALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYH 3458
Query: 657 NLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPD 700
QP N C +NGGC +LCL I P FTC CPD
Sbjct: 3459 PYRQPIVSNPC---GTNNGGCSHLCL----IKPGGKGFTCECPD 3495
Score = 467 bits (1201), Expect = e-131
Identities = 261/750 (34%), Positives = 378/750 (50%), Gaps = 76/750 (10%)
Query: 25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
++C F C++G+C+ ++CDG +C D SDE L+ TC S F+CG CIP
Sbjct: 1024 EQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGH--GECIP 1081
Query: 85 QFWRCDGQVDCDNGSDEQGCP---PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
WRCD + DC +GSDE CP P +C ++ C + +CIS+ +VCD+D DC DGSDE
Sbjct: 1082 AHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEK 1141
Query: 142 SC-PVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEW-------------------- 180
+C TC P+ F C + CI + CD D DC DGSDE
Sbjct: 1142 NCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCI 1201
Query: 181 --PQRCRGLYVFQGDSSP----------CSAFEFHCLS-GECIHSSWRCDGGPDCKDKSD 227
RC G++ +S C + EF C G CI + W CDG PDC SD
Sbjct: 1202 GVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSD 1261
Query: 228 EEN-CAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHS 286
E N C TC F C +GNCIH + CDR+ DC DMSDE C F+C S
Sbjct: 1262 EHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPT-------QPFRCPS 1314
Query: 287 GE--------CITLDKVCNMARDCRDWSDE-PIKECGTNECLDNNGGCSHVCNDLKIGYE 337
+ C+ L VC+ DC + +DE P+ C N C D NGGC+H C G +
Sbjct: 1315 WQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--CNGNSCSDFNGGCTHECVQEPFGAK 1372
Query: 338 CLCPDGFQLVAQRR-CEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVG 396
CLCP GF L + CEDIDEC +CSQ C N+ G ++C C+ G+ L+ + CK
Sbjct: 1373 CLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTA 1432
Query: 397 SIAYLFFT---NRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICS 453
S + L N+ +T SL+ N +VA+D + S RI+WSD +Q S
Sbjct: 1433 SESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWS 1492
Query: 454 TQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFR 513
+ V I + +A+DW+ N+YWTD L T+ V+ G R L
Sbjct: 1493 A----FQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLIS 1548
Query: 514 ENGSKPRAIVVDPVHG--FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL 571
+N + PR + +DP ++W+DWG +I++ ++G +V + I WP G+T+D
Sbjct: 1549 KNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYP 1608
Query: 572 SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSA 631
+ LY++DS L + D NG +R+ ++ + + HP++L +FED V+WTD + A
Sbjct: 1609 NRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRA 1668
Query: 632 NRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHS 691
N+ G + +++ N+ P +V H QP VN C + C +LCL + Q PH
Sbjct: 1669 NKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPC-----AFSRCSHLCLLSSQ-GPHF 1722
Query: 692 PKFTCACPDGMLLARDMRSCLTEAEAAVAT 721
++C CP G L+ D+ +CL + + + T
Sbjct: 1723 --YSCVCPSGWSLSPDLLNCLRDDQPFLIT 1750
Score = 425 bits (1093), Expect = e-119
Identities = 243/718 (33%), Positives = 363/718 (50%), Gaps = 48/718 (6%)
Query: 15 LLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFS 74
L+A A G C+ F+C G CI W CDG+ +C D +DE C VTC+ G F
Sbjct: 16 LVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEI--GCAVVTCQQGYFK 73
Query: 75 CGGRVNRCIPQFWRCDGQVDCDNGSDE-QGCPPKTCSQDEFRCHDGKCISRQFVCDSDRD 133
C +CIP W CD DCD+GSDE Q C TCS + C +G+CI ++ CD RD
Sbjct: 74 CQSE-GQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRD 132
Query: 134 CLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGD 193
C DG+DE C TC C++ C CD DC D SDE C +
Sbjct: 133 CPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDE--INCTEI------ 182
Query: 194 SSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSR 253
C EF C +GECI ++ CD DC+D SDE C TC +F C G CI+ +
Sbjct: 183 ---CLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNW 239
Query: 254 QCDREYDCKDMSDEVGCV----NVTLCEGPNKFKC-HSGECITLDKVCNMARDCRDWSDE 308
CD E DCKD DE GC +V C P ++ C SG CI++ KVC+ DC DE
Sbjct: 240 VCDGEDDCKDNGDEDGCESGPHDVHKC-SPREWSCPESGRCISIYKVCDGILDCPGREDE 298
Query: 309 ----PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL--VAQRRCEDIDECQDPD 362
K C C N C + C++ G C CP G+ + R C + D+CQ
Sbjct: 299 NNTSTGKYCSMTLCSALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWG 356
Query: 363 TCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSI--AYLFFTNRHEVRKMTLDRSEYT 420
C Q C + G + C CEEG+ L+ + CKA S A + F+N ++ + +
Sbjct: 357 ICDQKCESRPGRHLCHCEEGYILE-RGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFR 415
Query: 421 SLIPNLRNVVALDT--EVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDG 478
L+ + VA+ R++W+D Q + S ++ + V++ ++ P+
Sbjct: 416 ILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGL----NIQEVLNVSVETPEN 471
Query: 479 LAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDW-- 536
LAVDW+++ IY ++ + + + + G R TL EN PR I VDP G+++++DW
Sbjct: 472 LAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWES 531
Query: 537 --GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGN 594
G P K+++ ++G + LV + WP G+TLD++S R+YWVDS+ I ++ +G
Sbjct: 532 LSGEP-KLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQ 590
Query: 595 RKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL 654
RKT++ + HPF +++FE +VF+TD A+ AN+ T ++ + + L P + +
Sbjct: 591 RKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTV 650
Query: 655 FHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
+H+L QP N C+ +NGGC+ +C+ + + + F C C G L D R C+
Sbjct: 651 YHSLRQPYATNPCKD---NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCI 705
Score = 389 bits (998), Expect = e-108
Identities = 251/813 (30%), Positives = 362/813 (44%), Gaps = 155/813 (19%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C+ NE+QC + +CI W CD +C+D SDE C S TC+ G F C RCIPQ
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCAN--GRCIPQA 3651
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQD--------EFRCHDG-KCISRQFVCDSDRDCLDG 137
W+CD DC + SDE P + C EF C +CI + VC+ DC D
Sbjct: 3652 WKCDVDNDCGDHSDE---PIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDN 3708
Query: 138 SDEASCPVLTCGP-ASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSP 196
SDE C TC P F+C + CIP W CD DC D SDE + C
Sbjct: 3709 SDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDE--ENCA--------PRE 3758
Query: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCD 256
C+ EF C++ +CI S W CD DC D SDE +C + TC P+ FQC+ G+C+H +CD
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCD 3818
Query: 257 REYDCKDMSDEVGC---------VNVTL-------------------------------- 275
DC D SDE C T+
Sbjct: 3819 GSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLC 3878
Query: 276 ----CEGPNKFKCHSGECITLDKVCNMARDCRDWSDE-----------PIKE----CGTN 316
C PN+F+C + CI +VCN DC D +DE P E CG
Sbjct: 3879 LDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNG 3938
Query: 317 ECLDNNGGCSHV-----------CNDLKI------------------GYECLCPDGFQ-- 345
C+ ++ C CN K G+ C C GF+
Sbjct: 3939 HCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETN 3998
Query: 346 LVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGF--QLDPHTKACKAVGSIAYLFF 403
+ + C DI+EC+ TC Q C N +G Y+C C +GF D K C A GS L
Sbjct: 3999 VFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLL 4058
Query: 404 TNRHEVRKMTLDRSEYTSLIPNLRNVVALD-----TEVASNRIYWS---------DLSQR 449
+ +RK L ++ + + + A+D ++ + +Y++ + +
Sbjct: 4059 PDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRA 4118
Query: 450 MICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRK 509
I + + R + V D + + + PDG+AVDW+ +IYW+D + VA G RK
Sbjct: 4119 YIPNFESGRNNLVQEVDLKL-KYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRK 4177
Query: 510 TLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 569
L + +P AI V+P G M+WTDWG KI+ +NG D LV E++ WP G+++D
Sbjct: 4178 WLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSID 4237
Query: 570 LLSG-RLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAI 628
L+ R+YW D K I +I +G +R+ I K +P+SL +FED+++W +
Sbjct: 4238 YLNNDRIYWSDFKEDVIETIKYDGTDRRVI---AKEAMNPYSLDIFEDQLYWISKEKGEV 4294
Query: 629 FSANRL-TGSDVNLLAENLLSPEDMVLFHNLTQPRGV-NWCERTTLSNGGCQYLCLPAPQ 686
+ N+ G L N + + +FH L + V N C++ C +LCL P
Sbjct: 4295 WKQNKFGQGKKEKTLVVNPWLTQ-VRIFHQLRYNKSVPNLCKQI------CSHLCLLRP- 4346
Query: 687 INPHSPKFTCACPDGMLLARDMRSCLTEAEAAV 719
++CACP G + + TE +AA+
Sbjct: 4347 -----GGYSCACPQG---SSFIEGSTTECDAAI 4371
Score = 190 bits (483), Expect = 4e-48
Identities = 125/381 (32%), Positives = 168/381 (44%), Gaps = 49/381 (12%)
Query: 49 SAECQDGSDESQ---ETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQG-C 104
+ EC D Q T C S F C +CIP +W+CDGQ DC +GSDE C
Sbjct: 3490 TCECPDDFRTLQLSGSTYCMPMCSSTQFLCANN-EKCIPIWWKCDGQKDCSDGSDELALC 3548
Query: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDE--ASCPVLTCGPASFQCNSSTCIP 162
P + C +F+C DG C S Q +C++ ++C DGSDE C C +QC + CIP
Sbjct: 3549 PQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIP 3608
Query: 163 QLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDC 222
+ W CD DCED SDE C S C +F C +G CI +W+CD DC
Sbjct: 3609 ESWQCDTFNDCEDNSDEDSSHCA--------SRTCRPGQFRCANGRCIPQAWKCDVDNDC 3660
Query: 223 KDKSDE--ENCAVATCRPD---EFQC-SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLC 276
D SDE E C + D EF C ++ CI C+ DC+D SDE GC T C
Sbjct: 3661 GDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERT-C 3719
Query: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDE---PIKECGTNE-------CLDNNGGCS 326
F+C + CI L C+ DC D SDE +EC +E C+ + C
Sbjct: 3720 HPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICD 3779
Query: 327 HV--CNDLKIGYEC----------LCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGG 374
H C D +C C G + ++ +C+ +C D + G
Sbjct: 3780 HYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDG 3839
Query: 375 YKCQ-----CEEGFQLDPHTK 390
CQ C+ + P+ K
Sbjct: 3840 AYCQATMFECKNHVCIPPYWK 3860
Score = 179 bits (454), Expect = 1e-44
Identities = 114/402 (28%), Positives = 194/402 (48%), Gaps = 53/402 (13%)
Query: 315 TNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG- 373
TN C DNNGGC VC V R ++ +G
Sbjct: 660 TNPCKDNNGGCEQVC-----------------VLSHRTDN-----------------DGL 685
Query: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTS-LIPNLRN---V 429
G++C+C GFQLD + C AV + +L F+++ +R + S ++P N
Sbjct: 686 GFRCKCTFGFQLDTDERHCIAVQN--FLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFF 743
Query: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489
V +D + + I++SD+S+ MI ++D + + + + ++ + LA DWI N+Y
Sbjct: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDG----TGREILAANRVENVESLAFDWISKNLY 799
Query: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549
WTDS ++SV R+T+ + + PR++VV P G++++TDW PAKI + +G
Sbjct: 800 WTDSHYKSISVMRLADKTRRTVVQYLNN-PRSVVVHPFAGYLFFTDWFRPAKIMRAWSDG 858
Query: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609
+ ++ + WPNG+ +D + RLYWVD+ I +G +R+ + E ++ HPF
Sbjct: 859 SHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIE-QMTHPF 917
Query: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCER 669
LA+F + +F+TD AI + G ++ ++ + + + ++ G N C +
Sbjct: 918 GLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSY-DVNIQTGSNACNQ 976
Query: 670 TTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
T NG C + C P P + C CP GM LA + +C
Sbjct: 977 PTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013
Score = 166 bits (420), Expect = 9e-41
Identities = 124/423 (29%), Positives = 188/423 (44%), Gaps = 87/423 (20%)
Query: 312 ECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
E N CL+NNGGCSH LC L
Sbjct: 2340 EVNNNPCLENNGGCSH---------------------------------------LCFAL 2360
Query: 372 EGGY--KCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNL--- 426
G + KC C G L K C A+ + +L F + +R + LD ++ +
Sbjct: 2361 PGLHTPKCDCAFG-TLQSDGKNC-AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
Query: 427 RNVVALDTEVASNRIYWS-DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH 485
R V++LD + S+RIY++ +L+ + + + G+ + TVI+ I DG+A DWI
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHT-PTVIASGIGTADGIAFDWIT 2477
Query: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKG 545
IY++D + ++ G R + R KPRAIV+DP G++YW DW T AKI++
Sbjct: 2478 RRIYYSDYLNQMINSMAEDGSNRTVIARV--PKPRAIVLDPCQGYLYWADWDTHAKIERA 2535
Query: 546 GLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRL 605
L G +V ++ P+G+TLD LYWVD+ L I + G +R+ I+
Sbjct: 2536 TLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIV---NAA 2592
Query: 606 AHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN 665
H F L ++ ++WTD+ + I+ AN+ GS + NLLS QPRG+N
Sbjct: 2593 VHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLS-----------QPRGIN 2641
Query: 666 W------------CERTTLSNGGCQYLCLPAPQINPHSPKFTCACP--DGMLLARDMRSC 711
CE+ NGGC ++C P P C CP LA + + C
Sbjct: 2642 TVVKNQKQQCNNPCEQ---FNGGCSHICAPGPN------GAECQCPHEGNWYLANNRKHC 2692
Query: 712 LTE 714
+ +
Sbjct: 2693 IVD 2695
Score = 164 bits (415), Expect = 3e-40
Identities = 111/390 (28%), Positives = 193/390 (49%), Gaps = 24/390 (6%)
Query: 343 GFQLVAQRRC-EDIDECQDP-DTCSQLCVNLEGG-YKCQCEEGFQLDPHTKACKAVGSIA 399
G Q+ +R E + C + + C Q+C+ + GG + C C GF+L+P ++C S
Sbjct: 2006 GLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS-- 2063
Query: 400 YLFFTNRHEVRKMTLDRSEYT-SLIPNL---RNVVALDTEVASNRIYWSDLSQRMICSTQ 455
++ + +R +L+ S+++ +++P RN + +D +V+S IYW D S +
Sbjct: 2064 FIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNA 2123
Query: 456 LDRAH-GVSSYDTVISRDI--QAPDGLAVDWIHSNIYWTDSVLGT--VSVADTKGVKRKT 510
+ R SS +++ I G+AVDW+ N+Y+T++ + + V R+
Sbjct: 2124 IRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRV 2183
Query: 511 LFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDL 570
L + PR IVVDP + +++W D+G KI++ L+ + LV+E I P G+ +D
Sbjct: 2184 LLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDR 2243
Query: 571 LSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFS 630
G +YWVD L I+ I +NG N + ++ R P+ + VFE+ + W D + IF
Sbjct: 2244 SDGYVYWVDDSLDIIARIRINGENSE-VIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQ 2302
Query: 631 ANR--LTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTL--SNGGCQYLCLPAPQ 686
A++ ++ +N+ D+ +F QPR +NGGC +LC P
Sbjct: 2303 ASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPG 2362
Query: 687 INPHSPKFTCACPDGMLLARDMRSCLTEAE 716
+ H+PK C C G L + D ++C E
Sbjct: 2363 L--HTPK--CDCAFGTLQS-DGKNCAISTE 2387
Score = 134 bits (337), Expect = 4e-31
Identities = 80/228 (35%), Positives = 107/228 (46%), Gaps = 29/228 (12%)
Query: 136 DGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
+G P CG SF C + C+P + CD DC D SDE Q C L ++
Sbjct: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDE--QLCGTL------NN 1065
Query: 196 PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC---AVATCRPDEFQCSDGNCIHGS 252
CS+ F C GECI + WRCD DC D SDE NC A A+C ++ C + CI +
Sbjct: 1066 TCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKN 1125
Query: 253 RQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE 312
CD + DC D SDE C + C+ P++F C + CI L VC+ +DC D SDE
Sbjct: 1126 WVCDTDNDCGDGSDEKNCNSTETCQ-PSQFNCPNHRCIDLSFVCDGDKDCVDGSDEV--- 1181
Query: 313 CGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
GC V N ++C D + RC+ + +C D
Sbjct: 1182 -----------GC--VLNCTASQFKCASGDKC-IGVTNRCDGVFDCSD 1215
Score = 130 bits (328), Expect = 4e-30
Identities = 102/368 (27%), Positives = 171/368 (46%), Gaps = 38/368 (10%)
Query: 364 CSQLCVNLEGG---YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYT 420
CS LC+ G Y C C G+ L P C +L +H + ++L+ +
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQ-PFLITVRQHIIFGISLNPEVKS 1767
Query: 421 S--LIP--NLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVI-SRDIQA 475
+ ++P ++N + ++ + A IYW + ++ R + TV S +
Sbjct: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVENPG------EIHRVKTDGTNRTVFASISMVG 1821
Query: 476 PD-GLAVDWIHSNIYWTDSVLGTVSVADTKGV--KRKTLFRENGSK-----PRAIVVDPV 527
P LA+DWI N+Y T+ ++ V G RKTL +G+ P I VDP
Sbjct: 1822 PSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPA 1881
Query: 528 HGFMYWTDWGT----PAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLH 583
G +YW+D GT PAKI ++G + +L T N++ +TLD+ +LYW +
Sbjct: 1882 RGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRG 1941
Query: 584 SISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLA 643
I +V+G +R ++ +L+HP+ +AV + +++TD E I ++ TG++ +L
Sbjct: 1942 VIERGNVDGTDRMILVH---QLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLR 1998
Query: 644 ENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGML 703
+N+ + + ++H N C + CQ +CLP P F+CAC G
Sbjct: 1999 DNVPNLRGLQVYHRRNAAESSNGCSN---NMNACQQICLPVP-----GGLFSCACATGFK 2050
Query: 704 LARDMRSC 711
L D RSC
Sbjct: 2051 LNPDNRSC 2058
Score = 102 bits (253), Expect = 2e-21
Identities = 53/126 (42%), Positives = 68/126 (53%), Gaps = 8/126 (6%)
Query: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGD-FSCGGRVNRC 82
G C+ F+C++ CI W CDG +C DGSDE CL V C S + F C NRC
Sbjct: 3839 GAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDN--NRC 3896
Query: 83 IPQFWRCDGQVDCDNGSD--EQGC---PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
I C+G DC +G+D E+ C PK C++ E++C +G CI VCD DC D
Sbjct: 3897 IYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDW 3956
Query: 138 SDEASC 143
SDE C
Sbjct: 3957 SDELGC 3962
Score = 98.2 bits (243), Expect = 3e-20
Identities = 62/190 (32%), Positives = 86/190 (45%), Gaps = 17/190 (8%)
Query: 184 CRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVA--TCRPDEF 241
C G + + C F F C +G C+ + + CDG DC D SDE+ C TC F
Sbjct: 1013 CEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
Query: 242 QCSDGNCIHGSRQCDREYDCKDMSDEVGC-VNVTLCEGPNKFKCHSGECITLDKVCNMAR 300
C G CI +CD+ DC D SDE C + ++ C + +CI+ + VC+
Sbjct: 1073 TCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDN 1132
Query: 301 DCRDWSDEPIKECGTNE-CLDNNGGC-SHVCNDLKI--GYECLCPDGFQLV--------A 348
DC D SDE K C + E C + C +H C DL + C DG V +
Sbjct: 1133 DCGDGSDE--KNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTAS 1190
Query: 349 QRRCEDIDEC 358
Q +C D+C
Sbjct: 1191 QFKCASGDKC 1200
Score = 37.0 bits (84), Expect = 0.078
Identities = 16/33 (48%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Query: 315 TNECLDNNGGCSHVC--NDLKIGYECLCPDGFQ 345
+N C NNGGCSH+C G+ C CPD F+
Sbjct: 3466 SNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFR 3498
Score = 35.8 bits (81), Expect = 0.17
Identities = 15/31 (48%), Positives = 17/31 (54%)
Query: 311 KECGTNECLDNNGGCSHVCNDLKIGYECLCP 341
K+ N C NGGCSH+C G EC CP
Sbjct: 2648 KQQCNNPCEQFNGGCSHICAPGPNGAECQCP 2678
Score = 32.7 bits (73), Expect = 1.5
Identities = 19/68 (27%), Positives = 25/68 (36%), Gaps = 9/68 (13%)
Query: 325 CSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGY--------- 375
CSH+C GY C CP G + E + P C + GG
Sbjct: 4338 CSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLP 4397
Query: 376 KCQCEEGF 383
KC+C G+
Sbjct: 4398 KCKCPSGY 4405
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 230 bits (586), Expect = 5e-60
Identities = 118/345 (34%), Positives = 191/345 (55%), Gaps = 15/345 (4%)
Query: 392 CKAVGSIAYLFFTNRHEVRKM--TLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQR 449
C + + L + NR ++R + T + T ++ L + A+D + IYWSD+S+
Sbjct: 14 CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
Query: 450 MICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRK 509
I T+ ++ V + V+ + +PDGLA DW+ +YWTDS + V++ G RK
Sbjct: 74 AIKRTEFNKTESVQN---VVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRK 130
Query: 510 TLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLD 569
LF + +PRAI +DP GFMYWTDWG KI++ G++G + ++ I WPNG+TLD
Sbjct: 131 VLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLTLD 190
Query: 570 LLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIF 629
+LYW D+KL+ I +++G NR+ +++ L HPF+L +FED ++WTD +I
Sbjct: 191 YEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGS--LPHPFALTLFEDILYWTDWSTHSIL 248
Query: 630 SANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINP 689
+ N+ TG + + ++ SP D+ F QP N C + NGGC +LCL ++P
Sbjct: 249 ACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC---GIDNGGCSHLCL----MSP 301
Query: 690 HSPKFTCACPDGMLLARDMRSCLTEA-EAAVATQETSTVRLKVSS 733
P + CACP G+ L + ++C A E + + T R+ + +
Sbjct: 302 VKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDT 346
Score = 219 bits (558), Expect = 9e-57
Identities = 130/420 (30%), Positives = 209/420 (49%), Gaps = 60/420 (14%)
Query: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEG 373
G+N C + NGGCSH+C G C CP GF+L++ D+ C P+
Sbjct: 588 GSNPCAEENGGCSHLCLYRPQGLRCACPIGFELIS-----DMKTCIVPE----------- 631
Query: 374 GYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIP--NLRNVVA 431
A+L F+ R ++R+++L+ + IP ++ A
Sbjct: 632 -------------------------AFLLFSRRADIRRISLETNNNNVAIPLTGVKEASA 666
Query: 432 LDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWT 491
LD +V NRIYW+D+S + I ++ S+ + V+ + P+G+AVDW+ N+YW
Sbjct: 667 LDFDVTDNRIYWTDISLKTISRAFMNG----SALEHVVEFGLDYPEGMAVDWLGKNLYWA 722
Query: 492 DSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVD 551
D+ + V+ G R+ L ++ PRA+ +DP GFMYWT+WG KI + ++G +
Sbjct: 723 DTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSE 782
Query: 552 IYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSL 611
+LV N+ NG+T+D RLYW D + I S ++ G NR+ I +D L HPF L
Sbjct: 783 RTTLV-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADD---LPHPFGL 838
Query: 612 AVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTT 671
++D ++WTD +I AN+ +G + ++ +L D+++FH+ Q G N C
Sbjct: 839 TQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNEC---A 894
Query: 672 LSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKV 731
SNG C +LCL P F C CP L D R+C + +Q+++ R+ +
Sbjct: 895 SSNGHCSHLCLAVP-----VGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVI 949
Score = 217 bits (553), Expect = 3e-56
Identities = 148/480 (30%), Positives = 229/480 (47%), Gaps = 74/480 (15%)
Query: 315 TNECLDNNGGCSHVC--NDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLE 372
TN C +NGGCSH+C + +K Y+C CP G +L LE
Sbjct: 283 TNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKL------------------------LE 318
Query: 373 GGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI---PNLRNV 429
G K CK G+ L R ++R+++LD ++T ++ ++R+
Sbjct: 319 NG---------------KTCKD-GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
Query: 430 VALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIY 489
+A+D + IYW+D R I + +D S V++ I PDG+AVDW+ N+Y
Sbjct: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDG----SGSQFVVTAQIAHPDGIAVDWVARNLY 418
Query: 490 WTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNG 549
WTD+ + V G RK L E+ +PRAIV+DP+ G+MYWTDWG KI++ L+G
Sbjct: 419 WTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDG 478
Query: 550 VDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPF 609
D LV ++ WPNG+ LD G++YW D+K I ++ +G R+ ++ED ++ H F
Sbjct: 479 SDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVED--KIPHIF 536
Query: 610 SLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVL-FHNLTQPRGVNWCE 668
+ D V+WTD +I ++ ++ ++ + L P+ M L N+ + G N C
Sbjct: 537 GFTLLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQL--PDLMGLKATNVHRVIGSNPCA 593
Query: 669 RTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLT---------EAEAAV 719
NGGC +LCL PQ CACP G L DM++C+ A+
Sbjct: 594 E---ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRR 644
Query: 720 ATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRG 779
+ ET+ + + T V+ V D +R+ L T+ M+ AL V G
Sbjct: 645 ISLETNNNNVAIPLTGVKEASALDFDVTD-NRIYWTDISLKTISRAFMNGSALEHVVEFG 703
Score = 144 bits (362), Expect = 5e-34
Identities = 108/410 (26%), Positives = 180/410 (43%), Gaps = 61/410 (14%)
Query: 311 KECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN 370
++ G NEC +NG CSH+C + +
Sbjct: 886 RQSGWNECASSNGHCSHLCLAVPV------------------------------------ 909
Query: 371 LEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLI---PNLR 427
GG+ C C + L+ + C A +L F+ + + +M +D + +I +LR
Sbjct: 910 --GGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMVIDEQQSPDIILPIHSLR 965
Query: 428 NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY-DTVISRDIQA-PDGLAVDWIH 485
NV A+D + ++YW D Q MI Q D + G + +V S++++ P L++D
Sbjct: 966 NVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPSQNLEIQPYDLSIDIYS 1025
Query: 486 SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA-KIKK 544
IYWT ++V G + + +PRA+VV+P G+MY+T+ + KI++
Sbjct: 1026 RYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPEKGYMYFTNLQERSPKIER 1085
Query: 545 GGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKR 604
L+G + L + P + LD G+L+W DS L I S D++G NR I+ ++
Sbjct: 1086 AALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANR--IVLEDSN 1143
Query: 605 LAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAE---NLLSPEDMVLFHNLTQP 661
+ P L VFE+ ++W D + I + +TG + + LS V NL +
Sbjct: 1144 ILQPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQARIAQLSDIHAVKELNLQEY 1202
Query: 662 RGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSC 711
R NGGC ++CL C+CP ++L +D SC
Sbjct: 1203 RQ----HPCAQDNGGCSHICLVKGDGTTR-----CSCPMHLVLLQDELSC 1243
Score = 114 bits (286), Expect = 3e-25
Identities = 64/171 (37%), Positives = 83/171 (48%), Gaps = 37/171 (21%)
Query: 124 RQFVCDSDRD-----CL---DGSDEASCPVL--------------TCGPASFQCNSST-- 159
RQ C D CL DG+ SCP+ TC P F C +
Sbjct: 1203 RQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEID 1262
Query: 160 CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGG 219
CIP W CD +CED SDE + CS +F C SG+CI + RC+G
Sbjct: 1263 CIPVAWRCDGFTECEDHSDEL------------NCPVCSESQFQCASGQCIDGALRCNGD 1310
Query: 220 PDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270
+C+DKSDE+NC V C D+F+C++G CI ++CD DC D SDE+ C
Sbjct: 1311 ANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 105 bits (262), Expect = 2e-22
Identities = 51/119 (42%), Positives = 72/119 (60%), Gaps = 7/119 (5%)
Query: 192 GDSSPCSAFEFHCLSGE--CIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCI 249
G+ CS +F C +GE CI +WRCDG +C+D SDE NC V C +FQC+ G CI
Sbjct: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCASGQCI 1301
Query: 250 HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
G+ +C+ + +C+D SDE C + L + +F+C +G+CI K C+ DC D SDE
Sbjct: 1302 DGALRCNGDANCQDKSDEKNCEVLCLID---QFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 100 bits (250), Expect = 4e-21
Identities = 48/113 (42%), Positives = 64/113 (56%), Gaps = 3/113 (2%)
Query: 67 TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQF 126
TC F+C CIP WRCDG +C++ SDE CP CS+ +F+C G+CI
Sbjct: 1248 TCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCASGQCIDGAL 1305
Query: 127 VCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
C+ D +C D SDE +C VL C F+C + CI + CD++ DC D SDE
Sbjct: 1306 RCNGDANCQDKSDEKNCEVL-CLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 98.2 bits (243), Expect = 3e-20
Identities = 54/135 (40%), Positives = 69/135 (51%), Gaps = 16/135 (11%)
Query: 100 DEQGC-PPKTCSQDEFRCHDGK--CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN 156
DE C P TCS +F C G+ CI + CD +C D SDE +CPV C + FQC
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV--CSESQFQCA 1296
Query: 157 SSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRC 216
S CI C+ D +C+D SDE + C L C +F C +G+CI +C
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDE--KNCEVL---------CLIDQFRCANGQCIGKHKKC 1345
Query: 217 DGGPDCKDKSDEENC 231
D DC DKSDE +C
Sbjct: 1346 DHNVDCSDKSDELDC 1360
Score = 90.1 bits (222), Expect = 8e-18
Identities = 46/119 (38%), Positives = 59/119 (49%), Gaps = 9/119 (7%)
Query: 27 CERNEFQCQDGK--CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
C +F C G+ CI W CDG EC+D SDE C F C +CI
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELN----CPVCSESQFQCAS--GQCID 1302
Query: 85 QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
RC+G +C + SDE+ C C D+FRC +G+CI + CD + DC D SDE C
Sbjct: 1303 GALRCNGDANCQDKSDEKNCEV-LCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 64.3 bits (155), Expect = 5e-10
Identities = 32/80 (40%), Positives = 40/80 (50%), Gaps = 5/80 (6%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C ++FQC G+CI C+G A CQD SDE V C F C +CI +
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKN---CEVLCLIDQFRCAN--GQCIGKH 1342
Query: 87 WRCDGQVDCDNGSDEQGCPP 106
+CD VDC + SDE C P
Sbjct: 1343 KKCDHNVDCSDKSDELDCYP 1362
Score = 35.8 bits (81), Expect = 0.17
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 6/57 (10%)
Query: 310 IKECGTNECLDNNGGCSHVCNDLKIG-YECLCPDGFQLVAQRRCEDIDECQDPDTCS 365
++E + C +NGGCSH+C G C CP L+ +D C +P TCS
Sbjct: 1199 LQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLL-----QDELSCGEPPTCS 1250
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 229 bits (583), Expect = 1e-59
Identities = 130/399 (32%), Positives = 208/399 (52%), Gaps = 22/399 (5%)
Query: 318 CLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDT--CSQLCVNLEG-G 374
C N CSH C G C CP+G V +R + C PD CSQLCV L
Sbjct: 401 CPRNVSECSHDCVLTSEGPLCFCPEGS--VLERDGKTCSGCSSPDNGGCSQLCVPLSPVS 458
Query: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVV-ALD 433
++C C G+ L K+C A G +L F N ++R M D ++Y +L+ +V ALD
Sbjct: 459 WECDCFPGYDLQLDEKSCAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALD 518
Query: 434 TEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDS 493
+ N+IY++ + + I +D S + +I + P+GLAVDWI YWTD
Sbjct: 519 HDPVENKIYFAHTALKWIERANMDG----SQRERLIEEGVDVPEGLAVDWIGRRFYWTDR 574
Query: 494 VLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIY 553
+ +D G + K + +EN S+PR I V P+ ++WTD G +I+ L G+
Sbjct: 575 GKSLIGRSDLNGKRSKIITKENISQPRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRL 634
Query: 554 SLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAV 613
+ + ++ WP+GIT+D L+ +LYW D+K I +++G R+ + +++ + HPF++AV
Sbjct: 635 VIASSDLIWPSGITIDFLTDKLYWCDAKQSVIEMANLDGSKRRRLTQND--VGHPFAVAV 692
Query: 614 FEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLS 673
FED V+++D ++ N+ TG D L ++L P +V+ H L +P G + C
Sbjct: 693 FEDYVWFSDWAMPSVMRVNKRTGKDRVRLQGSMLKPSSLVVVHPLAKP-GADPC---LYQ 748
Query: 674 NGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
NGGC+++C C+C +G + A D ++CL
Sbjct: 749 NGGCEHIC------KKRLGTAWCSCREGFMKASDGKTCL 781
Score = 103 bits (257), Expect = 7e-22
Identities = 88/364 (24%), Positives = 164/364 (45%), Gaps = 34/364 (9%)
Query: 369 VNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRN 428
V+L C EG C VG +L F++ + + ++ + + Y L+ +
Sbjct: 18 VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75
Query: 429 VVALDTEVASNRIYWSDLSQRMICSTQLD--RAHGVSSYDTVISRDIQAPDGLAVDWIHS 486
V +D RIYW DL ++++ L+ R V + + +S G+A++WI+
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEKNVS-------GMAINWINE 128
Query: 487 NIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGG 546
+ W++ G ++V D KG L P + VDPV F++W+ + +
Sbjct: 129 EVIWSNQQEGIITVTDMKGNNSHILLSAL-KYPANVAVDPVERFIFWSS-EVAGSLYRAD 186
Query: 547 LNGVDIYSLVTENIQWPNGITLDLLSGRLYWV----DSKLHSISSIDVNGGNRKTILEDE 602
L+GV + +L+ E + ++LD+L RL+W+ + I S D +GG+ +
Sbjct: 187 LDGVGVKALL-ETSEKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDGGS--VHISKH 243
Query: 603 KRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSD---VNLLAENLLSPEDMVLFHNLT 659
+ F++++F D++F++ + I+ AN+ TG D +N L + + ++ + H L
Sbjct: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRIN-LHSSFVPLGELKVVHPLA 302
Query: 660 QPRGVN--W---CERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE 714
QP+ + W + L G C + + H C C +G L+RD + C
Sbjct: 303 QPKAEDDTWEPEQKLCKLRKGNCS-STVCGQDLQSH----LCMCAEGYALSRDRKYCEDV 357
Query: 715 AEAA 718
E A
Sbjct: 358 NECA 361
Score = 72.0 bits (175), Expect = 2e-12
Identities = 86/350 (24%), Positives = 136/350 (38%), Gaps = 31/350 (8%)
Query: 318 CLDNNGGCSH-VCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-PDTCSQLCVNLEGG 374
C G CS VC + C+C +G+ L R+ CED++EC C+ C N G
Sbjct: 318 CKLRKGNCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNTPGS 377
Query: 375 YKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDT 434
Y C C GF L P K C + S N E + SE +V+ D
Sbjct: 378 YYCTCPVGFVLLPDGKRCHQLVSCP----RNVSECSHDCVLTSEGPLCFCPEGSVLERDG 433
Query: 435 EVASNRIYWSDLSQRMIC------STQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
+ S + +C S + D G YD + A G + +N
Sbjct: 434 KTCSGCSSPDNGGCSQLCVPLSPVSWECDCFPG---YDLQLDEKSCAASGPQPFLLFANS 490
Query: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAK-IKKGGL 547
+ G TL + A+ DPV +Y+ T K I++ +
Sbjct: 491 Q-------DIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAH--TALKWIERANM 541
Query: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
+G L+ E + P G+ +D + R YW D I D+NG K I ++ ++
Sbjct: 542 DGSQRERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKE--NISQ 599
Query: 608 PFSLAV--FEDKVFWTDI-INEAIFSANRLTGSDVNLLAENLLSPEDMVL 654
P +AV ++FWTD IN I S++ + + + +L+ P + +
Sbjct: 600 PRGIAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITI 649
Score = 47.0 bits (110), Expect = 8e-05
Identities = 28/69 (40%), Positives = 35/69 (50%), Gaps = 7/69 (10%)
Query: 324 GCSHVCNDLKIGYE--CLCPDGFQLVAQRRCEDIDECQ-DPDTC---SQLCVNLEGGYKC 377
GCS + G + C C GF + C DIDEC+ C S C+N EGGY C
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAGDG-KLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
Query: 378 QCEEGFQLD 386
+C EG+Q D
Sbjct: 898 RCSEGYQGD 906
Score = 46.2 bits (108), Expect = 1e-04
Identities = 43/141 (30%), Positives = 52/141 (36%), Gaps = 17/141 (12%)
Query: 244 SDGNCIHGSRQCDREYDCKDMSD--EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD 301
S+ N E D D VGC C GE T + A D
Sbjct: 812 SEDNITESQHMLVAEIMVSDQDDCAPVGCSMYARC-------ISEGEDATCQCLKGFAGD 864
Query: 302 CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-D 360
+ SD E G C S C + + GY C C +G+Q C DIDECQ
Sbjct: 865 GKLCSDIDECEMGVPVCPP----ASSKCINTEGGYVCRCSEGYQGDGIH-CLDIDECQLG 919
Query: 361 PDTCSQ--LCVNLEGGYKCQC 379
+C + C N EGGY C C
Sbjct: 920 EHSCGENASCTNTEGGYTCMC 940
Score = 35.8 bits (81), Expect = 0.17
Identities = 14/36 (38%), Positives = 19/36 (52%)
Query: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGF 344
P+ + G + CL NGGC H+C C C +GF
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGF 771
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 228 bits (582), Expect = 1e-59
Identities = 153/442 (34%), Positives = 188/442 (42%), Gaps = 111/442 (25%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCK-SGDFSCGGRVNRCIPQ 85
C RN+++C +G CI+ W CD +C D SDE C + C F C CIP
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTICDLDTQFRCQ-ESGTCIPL 1134
Query: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
++CD + DC + SDE C C DE+ C G CI +VCD D DC D SDEA+C
Sbjct: 1135 SYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
Query: 146 L--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFH 203
+ TC ++FQC + CIPQ WACD D DC+DGSDE P C C+ F
Sbjct: 1195 IYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC---------EKKCNG--FR 1243
Query: 204 CLSGECIHSSWRCDGGPDCKDKSDEENC-------------------------------- 231
C +G CI SS CDG DC D SDE++C
Sbjct: 1244 CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
Query: 232 -------AVATCRPDE----------FQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVT 274
A A C D FQC +G CI +CD DC D SDE C N T
Sbjct: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
Query: 275 LCEGPN-----KFKCHSGECITLDKVCNMARDCRDWSDE---------PIKECGTNECLD 320
E PN +F+C +G CI C+ DC DWSDE P G + CL
Sbjct: 1364 --EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
Query: 321 NNGGCSH--------VCNDLKIGYECLCPDGFQ-----LVAQ----------RRCEDID- 356
N CS VC+ GY C DG L+A RC+ +
Sbjct: 1422 NYYRCSSGTCVMDTWVCD----GYRD-CADGSDEEACPLLANVTAASTPTQLGRCDRFEF 1476
Query: 357 ECQDPDTCSQLCVNLEGGYKCQ 378
EC P TC +G CQ
Sbjct: 1477 ECHQPKTCIPNWKRCDGHQDCQ 1498
Score = 226 bits (577), Expect = 5e-59
Identities = 138/381 (36%), Positives = 179/381 (46%), Gaps = 37/381 (9%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
+C +E+ C G CI WVCDG +C+D SDE+ T + TC++ +F C R CIPQ
Sbjct: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQ 1214
Query: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQ--DEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
W CDG DC +GSDE P C + + FRC +G CI CD RDC DGSDE C
Sbjct: 1215 RWACDGDTDCQDGSDED---PVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Query: 144 PVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
L F C N C+ CD C DGSDE G C F F
Sbjct: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE-DAAFAGCSQDPEFHKVCDEFGF 1330
Query: 203 HCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPD-----EFQCSDGNCIHGSRQCDR 257
C +G CI W+CDG DC D SDE NC T P+ +F+C +G+CI +CDR
Sbjct: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDR 1390
Query: 258 EYDCKDMSDEVGCVNVTLCEG---------PNKFKCHSGECITLDKVCNMARDCRDWSDE 308
E DC D SDE C + + PN ++C SG C+ VC+ RDC D SDE
Sbjct: 1391 ENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
Query: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD-------P 361
N + C+ + +EC P + +RC+ +CQD P
Sbjct: 1451 EACPLLANVTAASTPTQLGRCD--RFEFECHQPKTC-IPNWKRCDGHQDCQDGRDEANCP 1507
Query: 362 DTCSQLCVNLEGGYKCQCEEG 382
+ C++ E QCE+G
Sbjct: 1508 THSTLTCMSRE----FQCEDG 1524
Score = 209 bits (531), Expect = 1e-53
Identities = 137/393 (34%), Positives = 179/393 (45%), Gaps = 61/393 (15%)
Query: 21 TAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVN 80
TA+ CE + FQC++G CI +W CDG +CQDGSDE C K F C
Sbjct: 1193 TAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK---KCNGFRCPN--G 1247
Query: 81 RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD-GKCISRQFVCDSDRDCLDGSD 139
CIP CDG DC +GSDEQ C P +F C + +C+ VCD C DGSD
Sbjct: 1248 TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
Query: 140 E----ASCPV-----LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVF 190
E A C C FQC + CI +W CD DC D SDE C
Sbjct: 1308 EDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE--ANCEN---- 1361
Query: 191 QGDSSPCSA-FEFHCLSGECIHSSWRCDGGPDCKDKSDEENC-----------AVATCRP 238
++ CS F+F C +G CI + W+CD DC D SDE++C +TC P
Sbjct: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
Query: 239 DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC---VNVTLCEGPN--------KFKCHSG 287
+ ++CS G C+ + CD DC D SDE C NVT P +F+CH
Sbjct: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
Query: 288 E-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ- 345
+ CI K C+ +DC+D DE C T+ L C + E C DG
Sbjct: 1482 KTCIPNWKRCDGHQDCQDGRDE--ANCPTHSTL--------TC----MSREFQCEDGEAC 1527
Query: 346 LVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQ 378
+V RC+ +C D ++ + C + YK Q
Sbjct: 1528 IVLSERCDGFLDCSD-ESDEKACSDELTVYKVQ 1559
Score = 149 bits (376), Expect = 1e-35
Identities = 97/320 (30%), Positives = 161/320 (50%), Gaps = 22/320 (6%)
Query: 384 QLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL-IPNLRNVVALDTEVASNRIY 442
+L+ C ++ + R + + L L + LR VALD + N +Y
Sbjct: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLY 803
Query: 443 WSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD 502
WSDL+ +I L+ G + + +I+ ++ + LA + + +YW D+ + VA+
Sbjct: 804 WSDLALDVIQRLCLN---GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVAN 860
Query: 503 TKGVKRKTLFRENG-SKPRAIVVDPVHGFMYWTDWGT-PAKIKKGGLNGVDIYSLVTENI 560
G R T+ + +PRA+V+ P G M+WTDWG I + ++G Y LV+E++
Sbjct: 861 PDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDV 920
Query: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
+WPNGI++D +YW D+ L I I +G R IL++ L HP+++AVF+++++W
Sbjct: 921 KWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYW 975
Query: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680
D +IF A++ +GS + +LA L DM +F+ + G N C C L
Sbjct: 976 DDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK-GKNTGSNACVPRP-----CSLL 1029
Query: 681 CLPAPQINPHSPKFTCACPD 700
CLP N S C CP+
Sbjct: 1030 CLPKAN-NSRS----CRCPE 1044
Score = 137 bits (346), Expect = 3e-32
Identities = 90/278 (32%), Positives = 125/278 (44%), Gaps = 41/278 (14%)
Query: 104 CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL----TCGPASFQCNSST 159
C PK + RC + S D DC G + + TC ++C++
Sbjct: 1030 CLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGN 1089
Query: 160 CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSA-FEFHCL-SGECIHSSWRCD 217
CI +W CD D DC D SDE + C ++ C +F C SG CI S++CD
Sbjct: 1090 CINSIWWCDFDNDCGDMSDE--RNC--------PTTICDLDTQFRCQESGTCIPLSYKCD 1139
Query: 218 GGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV-TLC 276
DC D SDE +C + CR DE+ CS G CI S CD + DC+D SDE C + C
Sbjct: 1140 LEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTC 1199
Query: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDE-PIKECGTNECLDNNGGCSHVCNDLKIG 335
E N F+C +G CI C+ DC+D SDE P+ C CN +
Sbjct: 1200 EASN-FQCRNGHCIPQRWACDGDTDCQDGSDEDPV-------------NCEKKCNGFR-- 1243
Query: 336 YECLCPDGFQLVAQRRCEDIDEC---QDPDTCSQLCVN 370
CP+G + + + C+ + +C D C LC +
Sbjct: 1244 ----CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTH 1277
Score = 67.4 bits (163), Expect = 5e-11
Identities = 38/90 (42%), Positives = 50/90 (55%), Gaps = 4/90 (4%)
Query: 17 AAAGTAVGDRCERNEFQCQDGKCISYKWV-CDGSAECQDGSDESQ-ETCLSVTCKSGDFS 74
A+ T +G RC+R EF+C K W CDG +CQDG DE+ T ++TC S +F
Sbjct: 1462 ASTPTQLG-RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQ 1520
Query: 75 CGGRVNRCIPQFWRCDGQVDCDNGSDEQGC 104
C CI RCDG +DC + SDE+ C
Sbjct: 1521 CEDG-EACIVLSERCDGFLDCSDESDEKAC 1549
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 228 bits (581), Expect = 2e-59
Identities = 120/330 (36%), Positives = 185/330 (56%), Gaps = 13/330 (3%)
Query: 401 LFFTNRHEVRKMTLD--RSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDR 458
L F NR +VR + + E T ++ L + A+D + + +YW+D+S+ I T L++
Sbjct: 35 LLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQ 94
Query: 459 AHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSK 518
G + + VIS + +PDGLA DW+ +YWTDS + VA+ G RK LF ++ +
Sbjct: 95 T-GAAVQNVVIS-GLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQ 152
Query: 519 PRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWV 578
PRAI +DP HG+MYWTDWG +I++ G++G +V +I WPNG+T+DL +LYW
Sbjct: 153 PRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWA 212
Query: 579 DSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSD 638
D+KL I +++G R+ ++E L HPF+L + D ++WTD +I + N+ TG
Sbjct: 213 DAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGK 270
Query: 639 VNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCAC 698
+ L SP D+ + QP CE NGGC +LCL ++P P +TCAC
Sbjct: 271 RKEILSALYSPMDIQVLSQERQPFFHTRCEE---DNGGCSHLCL----LSPSEPFYTCAC 323
Query: 699 PDGMLLARDMRSCLTEAEAAVATQETSTVR 728
P G+ L + R+C AE + + +R
Sbjct: 324 PTGVQLQDNGRTCKAGAEEVLLLARRTDLR 353
Score = 224 bits (572), Expect = 2e-58
Identities = 134/389 (34%), Positives = 206/389 (52%), Gaps = 30/389 (7%)
Query: 351 RCEDIDECQDPDTCSQLCV--NLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHE 408
RCE+ D CS LC+ E Y C C G QL + + CKA G+ L R +
Sbjct: 298 RCEE-----DNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTD 351
Query: 409 VRKMTLDRSEYTSLI---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSY 465
+R+++LD ++T ++ ++R+ +A+D + +YW+D R I LD S
Sbjct: 352 LRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDG----SGA 407
Query: 466 DTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVD 525
T+++ +I PDG+AVDW+ N+YWTD+ + V G RK L E+ +PRAI +
Sbjct: 408 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALH 467
Query: 526 PVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSI 585
PV G MYWTDWG KI+ L+G + LV ++ WPNG+ LDL G+LYW D+K I
Sbjct: 468 PVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKI 527
Query: 586 SSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAEN 645
I+V+G R+T+LED +L H F + D ++WTD +I +++ S +++ +
Sbjct: 528 EVINVDGTKRRTLLED--KLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQ 584
Query: 646 LLSPEDMVL-FHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLL 704
L P+ M L N+ + G N C NGGC +LC PH+ + C CP G+ L
Sbjct: 585 L--PDLMGLKAVNVAKVVGTNPCAD---RNGGCSHLCF----FTPHATR--CGCPIGLEL 633
Query: 705 ARDMRSCLTEAEAAVATQETSTVRLKVSS 733
DM++C+ V T + R+ + +
Sbjct: 634 LSDMKTCIVPEAFLVFTSRAAIHRISLET 662
Score = 183 bits (464), Expect = 7e-46
Identities = 120/421 (28%), Positives = 195/421 (46%), Gaps = 61/421 (14%)
Query: 311 KECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN 370
K GTN C D NGGCSH LC
Sbjct: 598 KVVGTNPCADRNGGCSH---------------------------------------LCFF 618
Query: 371 LEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIP--NLRN 428
+C C G +L K C + A+L FT+R + +++L+ + IP ++
Sbjct: 619 TPHATRCGCPIGLELLSDMKTC--IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKE 676
Query: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
ALD +V++N IYW+D+S + I ++ SS + V+ + P+G+AVDW+ N+
Sbjct: 677 ASALDFDVSNNHIYWTDVSLKTISRAFMNG----SSVEHVVEFGLDYPEGMAVDWMGKNL 732
Query: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLN 548
YW D+ + VA G R+ L + PR++ +DP G++YWT+WG +I + ++
Sbjct: 733 YWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMD 792
Query: 549 GVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHP 608
G + +LV + + N +T+D RLYW D + I S ++ G R I +D L HP
Sbjct: 793 GTNCMTLV-DKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADD---LPHP 848
Query: 609 FSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCE 668
F L + D ++WTD +I A++ +G + L+ +L D+++FH+ Q G+N C
Sbjct: 849 FGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQD-GLNDCM 907
Query: 669 RTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVR 728
+NG C LCL P C C L R+C + +Q+++ R
Sbjct: 908 H---NNGQCGQLCLAIP------GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISR 958
Query: 729 L 729
+
Sbjct: 959 M 959
Score = 140 bits (352), Expect = 7e-33
Identities = 96/373 (25%), Positives = 170/373 (45%), Gaps = 30/373 (8%)
Query: 351 RCEDIDECQDPD-TCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEV 409
R + +++C + C QLC+ + GG++C C + LDP ++ C +L F+ + +
Sbjct: 899 RQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAI 956
Query: 410 RKMTLDRSEYTSLI---PNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYD 466
+M D LI LRNV A+D + IYW D Q + RA +
Sbjct: 957 SRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN------IKRAKDDGTQP 1010
Query: 467 TVISRDIQA------PDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPR 520
V++ Q P L++D ++WT T++V G + R + KPR
Sbjct: 1011 FVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPR 1070
Query: 521 AIVVDPVHGFMYWTDW-GTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVD 579
AIVV+ G++Y+T+ AKI++ L+G + L T + P + +D G+L+WVD
Sbjct: 1071 AIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD 1130
Query: 580 SKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDV 639
+ L I S D++G NR T+ ++ + P L + ++W D + I + TG
Sbjct: 1131 ADLKRIESCDLSGANRLTL--EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKR 1188
Query: 640 NLLAENLLSPEDMVLFHNLT-QPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCAC 698
+ + + ++ + + C R NGGC ++C+ P C+C
Sbjct: 1189 TRIQGRVAHLTGIHAVEEVSLEEFSAHPCAR---DNGGCSHICIAKGDGTPR-----CSC 1240
Query: 699 PDGMLLARDMRSC 711
P ++L +++ +C
Sbjct: 1241 PVHLVLLQNLLTC 1253
Score = 113 bits (282), Expect = 9e-25
Identities = 53/119 (44%), Positives = 72/119 (60%), Gaps = 7/119 (5%)
Query: 192 GDSSPCSAFEFHCLSGE--CIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCI 249
G+ CS +F C +GE CI +WRCDG P+C D+SDEE C V C +F C+ G C+
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCV 1311
Query: 250 HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
+CD E DC+D SDE C + L PN+F+C SG+C+ + + C+ DC D SDE
Sbjct: 1312 DLRLRCDGEADCQDRSDEADCDAICL---PNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 112 bits (280), Expect = 1e-24
Identities = 52/113 (46%), Positives = 65/113 (57%), Gaps = 3/113 (2%)
Query: 67 TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQF 126
TC F+C CIP WRCDG +CD+ SDE+GCP CS +F C G+C+ +
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
Query: 127 VCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
CD + DC D SDEA C + C P F+C S C+ CD+ PDC DGSDE
Sbjct: 1316 RCDGEADCQDRSDEADCDAI-CLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 110 bits (276), Expect = 4e-24
Identities = 61/152 (40%), Positives = 79/152 (51%), Gaps = 31/152 (20%)
Query: 136 DGSDEASCPV--------LTCG------PASFQCNSST--CIPQLWACDNDPDCEDGSDE 179
DG+ SCPV LTCG P F C + CIP W CD P+C+D SDE
Sbjct: 1233 DGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE 1292
Query: 180 WPQRCRGLYVFQGDSSP-CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP 238
+ P CSA +F C G+C+ RCDG DC+D+SDE +C A C P
Sbjct: 1293 -------------EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCD-AICLP 1338
Query: 239 DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270
++F+C+ G C+ +QCD DC D SDE+ C
Sbjct: 1339 NQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 94.7 bits (234), Expect = 3e-19
Identities = 49/121 (40%), Positives = 64/121 (52%), Gaps = 9/121 (7%)
Query: 27 CERNEFQCQDGK--CISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
C ++F C G+ CI W CDG EC D SDE E C C + F C +C+
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC--PVCSAAQFPCAR--GQCVD 1312
Query: 85 QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP 144
RCDG+ DC + SDE C C ++FRC G+C+ + CDS DC+DGSDE C
Sbjct: 1313 LRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE 1371
Query: 145 V 145
+
Sbjct: 1372 I 1372
Score = 93.2 bits (230), Expect = 9e-19
Identities = 51/137 (37%), Positives = 65/137 (47%), Gaps = 15/137 (10%)
Query: 106 PKTCSQDEFRCHDGK--CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQ 163
P TCS D+F C G+ CI + CD +C D SDE CPV C A F C C+
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV--CSAAQFPCARGQCVDL 1313
Query: 164 LWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCK 223
CD + DC+D SDE C + C +F C SG+C+ +CD PDC
Sbjct: 1314 RLRCDGEADCQDRSDE--ADCDAI---------CLPNQFRCASGQCVLIKQQCDSFPDCI 1362
Query: 224 DKSDEENCAVATCRPDE 240
D SDE C + D+
Sbjct: 1363 DGSDELMCEITKPPSDD 1379
Score = 58.2 bits (139), Expect = 3e-08
Identities = 30/91 (32%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C +F C G+C+ + CDG A+CQD SDE+ C F C +C+
Sbjct: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEAD---CDAICLPNQFRCAS--GQCVLIK 1352
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCH 117
+CD DC +GSDE C D+ H
Sbjct: 1353 QQCDSFPDCIDGSDELMCEITKPPSDDSPAH 1383
Score = 36.2 bits (82), Expect = 0.13
Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 6/57 (10%)
Query: 310 IKECGTNECLDNNGGCSHVCNDLKIGY-ECLCPDGFQLVAQRRCEDIDECQDPDTCS 365
++E + C +NGGCSH+C G C CP L+ +++ C +P TCS
Sbjct: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLL-----QNLLTCGEPPTCS 1260
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 195 bits (495), Expect = 2e-49
Identities = 127/382 (33%), Positives = 156/382 (40%), Gaps = 55/382 (14%)
Query: 27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
C E CQ+ G C+ + W+CD +C DGSDE E C + C G +C C+P
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE--EGCAAPGCGEGQMTCSS--GHCLPL 1431
Query: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC-P 144
CD Q DC +G+DE P C Q C DG+C+ +CD DCLD +DE SC
Sbjct: 1432 ALLCDRQDDCGDGTDEPSYP---CPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 145 VLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRC-------------------- 184
+TC P C TC+ + CD DC DG+DE P C
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548
Query: 185 ----RGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDE 240
+ PC FEF C SGEC WRCD DC D SDE C C P
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG-GPCAPHH 1607
Query: 241 FQCSDG-NCIHGSRQCDREYDCKDMSDE--VGCVNVTLCEGPNK-------FKCHSGECI 290
C+ G +C+ + CD C D SDE C + GPN+ + C +G CI
Sbjct: 1608 APCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCI 1667
Query: 291 TLDKVCNMARDC-RDWSDEPIKE---CGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL 346
VC+ DC R P E CG G CS C G C L
Sbjct: 1668 GFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPCSRTCGPWGQGRSRRCSPLGLL 1727
Query: 347 VAQRRCEDIDECQDPDTCSQLC 368
V Q C P+ SQ C
Sbjct: 1728 VLQ-------NCPGPEHQSQAC 1742
Score = 157 bits (396), Expect = 5e-38
Identities = 103/347 (29%), Positives = 141/347 (40%), Gaps = 89/347 (25%)
Query: 60 QETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD- 118
Q+ C + TC+ G + CGG D G E+ P C++ E C +
Sbjct: 1347 QKDCGNCTCQEGQWHCGG------------------DGGHCEELVP--ACAEGEALCQEN 1386
Query: 119 GKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSD 178
G C+ ++CD+ DC DGSDE C CG C+S C+P CD DC DG+D
Sbjct: 1387 GHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTD 1446
Query: 179 EWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENC-AVATCR 237
E S PC C G C+ + CDG PDC D +DEE+C TC
Sbjct: 1447 E-------------PSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCV 1493
Query: 238 PDEFQCSDGNCIHGSRQCDREYDCKDMSDE----------------------VGCVNVTL 275
P E C DG C+ + CD +DC D +DE G ++
Sbjct: 1494 PGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTAS 1553
Query: 276 CE----------GPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGC 325
GP +F+C SGEC C+ DC D SDE + CG C ++ C
Sbjct: 1554 SPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDE--RGCG-GPCAPHHAPC 1610
Query: 326 SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD-----PDTCSQL 367
+ G C+ P ++ C+ + +C D PD C L
Sbjct: 1611 AR-------GPHCVSP-------EQLCDGVRQCPDGSDEGPDACGGL 1643
Score = 89.0 bits (219), Expect = 2e-17
Identities = 89/342 (26%), Positives = 125/342 (36%), Gaps = 71/342 (20%)
Query: 42 YKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG--QVDCDNGS 99
Y+W + C G D + C ++ + + + G R WR + C+ G
Sbjct: 1226 YEWCLYDACGCDSGGD-CECLCSAIATYADECARHGHHVR-----WRSQELCSLQCEGGQ 1279
Query: 100 DEQGCPPK---TCSQDE----FRCHDGKCISRQFVCDSDRDCLDGS--DEASCPVLTCGP 150
+ C P TC + + C C+ F C G+ + ASCP G
Sbjct: 1280 VYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCF-CPEGTLLHGGACLEPASCPC-EWGR 1337
Query: 151 ASF--------QCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
SF C + TC W C D C L C+ E
Sbjct: 1338 NSFPPGSVLQKDCGNCTCQEGQWHCGGDGG----------HCEELV------PACAEGEA 1381
Query: 203 HCL-SGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDC 261
C +G C+ W CD DC D SDEE CA C + CS G+C+ + CDR+ DC
Sbjct: 1382 LCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDC 1441
Query: 262 KDMSDEVG--CVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKEC-GTNEC 318
D +DE C L C G C+ +C+ DC D +DE + C G C
Sbjct: 1442 GDGTDEPSYPCPQGLLA-------CADGRCLPPALLCDGHPDCLDAADE--ESCLGQVTC 1492
Query: 319 LDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
+ E C DG L A + C+ + +C D
Sbjct: 1493 VPG---------------EVSCVDGTCLGAIQLCDGVWDCPD 1519
Score = 70.5 bits (171), Expect = 6e-12
Identities = 74/291 (25%), Positives = 107/291 (36%), Gaps = 78/291 (26%)
Query: 52 CQDGSDESQETC--LSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTC 109
C+ GS + C + + C SG+ C+ + CDG +DC++GSDE+GC
Sbjct: 2224 CEPGSPPAP-LCPGVGLRCASGE---------CVLRGGPCDGVLDCEDGSDEEGCVLLPE 2273
Query: 110 SQDEFR----------CHDGKCIS--RQFVCDSDRDCLDGSDEASCPVLTC----GPAS- 152
F G+ + R+ + +++ G + + P T GPAS
Sbjct: 2274 GTGRFHSTAKTLALSSAQPGQLLHWPREGLAETEH-WPPGQESPTSPTETRPVSPGPASG 2332
Query: 153 -------FQCNSSTCIPQLWACDNDPDCEDGS-----DEWPQRCRGLYVFQGDSSP--CS 198
Q ++T IPQ+ A P + P G V G P C
Sbjct: 2333 VPHHGESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCG 2392
Query: 199 AFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAV------------------------- 233
+ C C+ + CDG DC D SDE +CA
Sbjct: 2393 PGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTM 2452
Query: 234 ---------ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTL 275
A C P + C G C+ R+CD DC+D SDE GCV+ L
Sbjct: 2453 ALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVL 2503
Score = 65.5 bits (158), Expect = 2e-10
Identities = 37/119 (31%), Positives = 46/119 (38%), Gaps = 24/119 (20%)
Query: 144 PVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE---------WPQRCRGLYV----- 189
P + CGP C C+ Q CD DC DGSDE W L+
Sbjct: 2387 PPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVP 2446
Query: 190 ----------FQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP 238
+ CS + C SGEC+ + RCD PDC+D SDE+ C P
Sbjct: 2447 FMMPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAP 2505
Score = 52.0 bits (123), Expect = 2e-06
Identities = 83/351 (23%), Positives = 108/351 (30%), Gaps = 88/351 (25%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQET----------------------- 62
+C + C+ C+ VCDG +C DGSDE
Sbjct: 2390 QCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMM 2449
Query: 63 ---------CLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC------PPK 107
C SCG C+ RCD + DC +GSDE GC P
Sbjct: 2450 PTMALPGLPASRALCSPSQLSCGS--GECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWS 2507
Query: 108 TCSQDEFRCHDGKCISRQFV---------CDSDRDCLDGSDEASCPVL-------TCGPA 151
S C G RQ + C DR +CPV GP
Sbjct: 2508 VWSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPC 2567
Query: 152 SFQCNSSTCIPQLWACDNDP-----DCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLS 206
S C Q D P C S E + GL PCS C
Sbjct: 2568 SVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQE--RAPCGL-------QPCSG-GTDCEL 2617
Query: 207 GECIHSSWRCDGG------PDCKDKSDEENCA---VATCRPDEFQCSDGNCIHGSRQCDR 257
G S+ C G P C D +C+ V CR C G +H +R C
Sbjct: 2618 GRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVEGCR-----CPPGLLLHDTR-CLP 2671
Query: 258 EYDCKDM-SDEVGCVNVTLCEGP-NKFKCHSGECITLDKVCNMARDCRDWS 306
+C + +E+ V+ G ++ C GE + C + WS
Sbjct: 2672 LSECPCLVGEELKWPGVSFLLGNCSQCVCEKGELLCQPGGCPLPCGWSAWS 2722
Score = 47.8 bits (112), Expect = 4e-05
Identities = 28/106 (26%), Positives = 42/106 (39%), Gaps = 34/106 (32%)
Query: 236 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCV------------------------ 271
C P + C C+ ++ CD DC D SDE C
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 272 ---------NVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
+ LC P++ C SGEC++ ++ C++ DC+D SDE
Sbjct: 2451 TMALPGLPASRALCS-PSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Score = 38.9 bits (89), Expect = 0.021
Identities = 36/138 (26%), Positives = 50/138 (36%), Gaps = 27/138 (19%)
Query: 155 CNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSW 214
C++ TC+ + C PDC D G++ G CS C GE + S
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPD---------PGVWSSWGPWEDCSV---SCGGGEQLRSR- 3670
Query: 215 RCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDR----EYDCKDMSDEVGC 270
RC P C+ CR E C G R+C + C ++ +VGC
Sbjct: 3671 RCARPPCPGPARQSRTCSTQVCR--EAGCPAGRLY---RECQPGEGCPFSCAHVTQQVGC 3725
Query: 271 VNVTLCEGPNKFKCHSGE 288
+ EG CH E
Sbjct: 3726 FSEGCEEG-----CHCPE 3738
Score = 38.1 bits (87), Expect = 0.035
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)
Query: 242 QCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKF 282
+C+ G C+ CD DC+D SDE GC V L EG +F
Sbjct: 2240 RCASGECVLRGGPCDGVLDCEDGSDEEGC--VLLPEGTGRF 2278
Score = 37.4 bits (85), Expect = 0.060
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 137 GSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
G + S P C +C S C+ + CD DCEDGSDE
Sbjct: 2223 GCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 33.1 bits (74), Expect = 1.1
Identities = 17/42 (40%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
E G LC G +C SGEC+ C+ DC D SDE
Sbjct: 2225 EPGSPPAPLCPGVG-LRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 32.3 bits (72), Expect = 1.9
Identities = 50/235 (21%), Positives = 69/235 (29%), Gaps = 68/235 (28%)
Query: 25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
+RC R Q+G VC C GS E C+ +
Sbjct: 4073 NRCPRRCSDLQEGIVCQDDQVCQKGCRCPKGSLEQDGGCVPI------------------ 4114
Query: 85 QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSD-----RDCLDGSD 139
G DC +D QG SQ + C++ C + Q C + C
Sbjct: 4115 ------GHCDC---TDAQGHSWAPGSQHQDACNNCSCQAGQLSCTAQPCPPPTHCAWSHW 4165
Query: 140 EASCPVL-TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPC- 197
A P +CGP Q + WA P+C + Q S PC
Sbjct: 4166 SAWSPCSHSCGPRGQQSRFRSSTSGSWA----PECREE--------------QSQSQPCP 4207
Query: 198 -SAFEFHCLSG---ECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNC 248
+ CL G + SW + C +C P+ C D C
Sbjct: 4208 QPSCPPLCLQGTRSRTLGDSWL------------QGECQRCSCTPEGVICEDTEC 4250
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 144 bits (363), Expect = 3e-34
Identities = 87/282 (30%), Positives = 144/282 (51%), Gaps = 29/282 (10%)
Query: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
++ L + +YW+D+++ I L HG T+I +D+ +P+G+AVD + NI
Sbjct: 980 IIGLAFDCVDKMVYWTDITEPSIGRASL---HG-GEPTTIIRQDLGSPEGIAVDHLGRNI 1035
Query: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTP-AKIKKGGL 547
+WTDS L + VA G +R+ LF + PR IV D V G +YWTDW KI+ +
Sbjct: 1036 FWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYM 1095
Query: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
+G + LV +++ PNG+T D S +L WVD+ + ++ + +R+ LE L +
Sbjct: 1096 DGTNRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRRKALEG---LQY 1152
Query: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAE-NLLSPEDMVLFHNLTQ-----P 661
PF++ + +++TD + N + D+ + E + P + +T P
Sbjct: 1153 PFAVTSYGKNLYFTD------WKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCP 1206
Query: 662 RGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGML 703
+G N+C +++NGGC +LCL P TC CPD L
Sbjct: 1207 QGHNYC---SVNNGGCTHLCLATPGSR------TCRCPDNTL 1239
Score = 57.0 bits (136), Expect = 7e-08
Identities = 50/164 (30%), Positives = 68/164 (41%), Gaps = 22/164 (13%)
Query: 234 ATCRPD---EFQCSDGNCIHGSRQCDRE-YDCKDMSDEVG-CVNVTLCEG-PNKFKCHSG 287
A CRP +F C C G R R YD + S++ C + T+C P F+C
Sbjct: 683 AACRPGPRTQFTCE---CSIGFRGDGRTCYDIDECSEQPSVCGSHTICNNHPGTFRC--- 736
Query: 288 ECITLDKVCNMARDCRDWSDEPIKEC--GTNEC-LDNNGGCSHVCNDLKIGYECLCPDGF 344
EC+ + + PI C G + C + C + Y C C GF
Sbjct: 737 ECVEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS---SYTCSCLPGF 793
Query: 345 QLVAQRRCEDIDECQDPDTC--SQLCVNLEGGYKCQCEEGFQLD 386
Q C+D+DECQ P C C N G + CQC+ G+Q D
Sbjct: 794 SGDGQA-CQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
Score = 35.0 bits (79), Expect = 0.30
Identities = 14/29 (48%), Positives = 16/29 (55%)
Query: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPD 342
G N C NNGGC+H+C C CPD
Sbjct: 1208 GHNYCSVNNGGCTHLCLATPGSRTCRCPD 1236
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 137 bits (346), Expect = 3e-32
Identities = 82/223 (36%), Positives = 110/223 (49%), Gaps = 30/223 (13%)
Query: 60 QETCLSVTCKSGD-FSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD 118
QE + C G+ F C + CIP +C+G DCD+ SDE C CS++ F CH
Sbjct: 261 QENGKQLLCGRGENFLCASGI--CIPGKLQCNGYNDCDDWSDEAHC---NCSENLFHCHT 315
Query: 119 GKCISRQFVCDSDRDCLDGSDEASCPVLTCGPAS-FQCNSSTCIPQLWACDNDPDCEDGS 177
GKC++ VCD DC D SDE +C C P + +C CI W CD D DC D S
Sbjct: 316 GKCLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKS 372
Query: 178 DEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAV--AT 235
DE C + + C +G+CI S+++CDG DCKD SDEENC+V +
Sbjct: 373 DEVNCSCHSQGLVE------------CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTS 420
Query: 236 CRPDEFQCSDGNCIH---GSRQCDREYDCKDMSDEVGCVNVTL 275
C+ + +C C+ GS CD + S C +TL
Sbjct: 421 CQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ---CEPITL 460
Score = 129 bits (325), Expect = 9e-30
Identities = 110/404 (27%), Positives = 166/404 (41%), Gaps = 99/404 (24%)
Query: 31 EFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS---VTCKSGDFSCGGRVNRCIPQFW 87
E +C DG+CI+ +WVCDG +C D SDE +C S V C++G +CIP +
Sbjct: 347 EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNG---------QCIPSTF 397
Query: 88 RCDGQVDCDNGSDEQGCP--PKTCSQDEFRCHDGKCISR---QFVCDSDRDCLDGSDEAS 142
+CDG DC +GSDE+ C +C + + RC C+ +CD + + S
Sbjct: 398 QCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEP 457
Query: 143 CPVLTC------------------------------GPASFQCNS------STCIPQLWA 166
+ C PA Q N +C +
Sbjct: 458 ITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPK 517
Query: 167 CD-----NDPDCEDGSDEWPQRCRGLYVFQG----DSSPCSAF----------------- 200
CD + P C + +RC + G + + CS F
Sbjct: 518 CDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYV 577
Query: 201 ------EFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP-DEFQC-SDGNCIHGS 252
F C SG+C+ +S RCDG DC D SDEENC C+ D ++C S+ C+ +
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG---CKERDLWECPSNKQCLKHT 634
Query: 253 RQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKE 312
CD DC D DE C + C+ ++ +C + C++ D C+ DC D SDE +
Sbjct: 635 VICDGFPDCPDYMDEKNC---SFCQ-DDELECANHACVSRDLWCDGEADCSDSSDE--WD 688
Query: 313 CGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ-LVAQRRCEDI 355
C T N S + +C DG+Q +++Q C+ +
Sbjct: 689 CVTLSI--NVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQM 730
Score = 128 bits (321), Expect = 3e-29
Identities = 78/215 (36%), Positives = 102/215 (47%), Gaps = 29/215 (13%)
Query: 27 CERNE-FQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
C R E F C G CI K C+G +C D SDE+ C F C +C+
Sbjct: 269 CGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAH-----CNCSENLFHC--HTGKCLNY 321
Query: 86 FWRCDGQVDCDNGSDEQGCP--PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
CDG DC + SDEQ C P T E RC DG+CI+ ++VCD D DC+D SDE +C
Sbjct: 322 SLVCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Query: 144 PVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFH 203
+ G +C + CIP + CD D DC+DGSDE + C + + C +
Sbjct: 378 SCHSQG--LVECRNGQCIPSTFQCDGDEDCKDGSDE--ENCSVI------QTSCQEGDQR 427
Query: 204 CLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP 238
CL C+ S C G C + NC + C P
Sbjct: 428 CLYNPCLDS---CGGSSLCDPNNSLNNC--SQCEP 457
Score = 121 bits (303), Expect = 3e-27
Identities = 84/240 (35%), Positives = 105/240 (43%), Gaps = 54/240 (22%)
Query: 146 LTCGPA-SFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC 204
L CG +F C S CIP C+ DC+D SDE C CS FHC
Sbjct: 267 LLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDE--AHCN-----------CSENLFHC 313
Query: 205 LSGECIHSSWRCDGGPDCKDKSDEENCAVATCRP-DEFQCSDGNCIHGSRQCDREYDCKD 263
+G+C++ S CDG DC D SDE+NC C P E +C DG CI CD ++DC D
Sbjct: 314 HTGKCLNYSLVCDGYDDCGDLSDEQNC---DCNPTTEHRCGDGRCIAMEWVCDGDHDCVD 370
Query: 264 MSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEP------------IK 311
SDEV C C +C +G+CI C+ DC+D SDE +
Sbjct: 371 KSDEVNC----SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQ 426
Query: 312 ECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNL 371
C N CLD+ GG S LC L +CE I +LC+NL
Sbjct: 427 RCLYNPCLDSCGGSS------------LCDPNNSLNNCSQCEPI--------TLELCMNL 466
Score = 92.0 bits (227), Expect = 2e-18
Identities = 54/155 (34%), Positives = 70/155 (45%), Gaps = 12/155 (7%)
Query: 25 DRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
+ C + F+C+ G+C+ CDG A+C D SDE E C CK D +C+
Sbjct: 578 EECSPSHFKCRSGQCVLASRRCDGQADCDDDSDE--ENC---GCKERDLWECPSNKQCLK 632
Query: 85 QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP 144
CDG DC + DE+ C C DE C + C+SR CD + DC D SDE C
Sbjct: 633 HTVICDGFPDCPDYMDEKNC--SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCV 690
Query: 145 VLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
L S NSS+ + A C DG E
Sbjct: 691 TL-----SINVNSSSFLMVHRAATEHHVCADGWQE 720
Score = 72.0 bits (175), Expect = 2e-12
Identities = 54/173 (31%), Positives = 75/173 (43%), Gaps = 28/173 (16%)
Query: 228 EENCAVATC-RPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHS 286
+EN C R + F C+ G CI G QC+ DC D SDE C C N F CH+
Sbjct: 261 QENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC----NC-SENLFHCHT 315
Query: 287 GECITLDKVCNMARDCRDWSDE------PIKE--CGTNECLDNNGGC--SHVCNDLKIGY 336
G+C+ VC+ DC D SDE P E CG C+ C H C D
Sbjct: 316 GKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEV 375
Query: 337 ECL--------CPDGFQLVAQRRCEDIDECQ---DPDTCSQLCVNL-EGGYKC 377
C C +G + + +C+ ++C+ D + CS + + EG +C
Sbjct: 376 NCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRC 428
Score = 46.6 bits (109), Expect = 1e-04
Identities = 34/121 (28%), Positives = 46/121 (38%), Gaps = 17/121 (14%)
Query: 275 LCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEP-------IKECGTNECLDNNGGCSH 327
LC F C SG CI CN DC DWSDE + C T +CL+ + C
Sbjct: 268 LCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDG 327
Query: 328 V--CNDLKIGYEC--------LCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKC 377
C DL C C DG + + C+ +C D + +G +C
Sbjct: 328 YDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVEC 387
Query: 378 Q 378
+
Sbjct: 388 R 388
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 131 bits (330), Expect = 2e-30
Identities = 78/239 (32%), Positives = 103/239 (43%), Gaps = 62/239 (25%)
Query: 106 PKTCSQDEFRCHD-GKCISRQFVCDSDRDCLDGSDEASC--PV----------------- 145
P+ C++ EF CH +C++ ++ CD DC D SDE +C PV
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 146 ---------------------------LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSD 178
L CGP C + CIP+ + CD DCEDGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 179 EWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAV----A 234
E + G PC EF C +G C WRCDG DC+D++DE NC
Sbjct: 316 E---------LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEE 366
Query: 235 TCRPDEFQCSDGN-CIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNK-FKCHSGECIT 291
C P +F+C N CI S CD E DC D SDE GC+ + P + + G+ +T
Sbjct: 367 VCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVT 425
Score = 113 bits (282), Expect = 9e-25
Identities = 66/205 (32%), Positives = 95/205 (46%), Gaps = 53/205 (25%)
Query: 27 CERNEFQCQD-GKCISYKWVCDGSAECQDGSDE--SQETCLSVT---------------- 67
C EF C +C++ ++ CD +C+D SDE +E L ++
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 68 --------------------------CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDE 101
C + +C R CIP+ + CDGQ DC++GSDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAAC--RNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 102 QGC-PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL----TCGPASFQC- 155
C PP C +EF C +G C + + CD D DC D +DEA+CP CGP F+C
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 156 NSSTCIPQLWACDNDPDCEDGSDEW 180
+++ CIP + CD + DC D SDE+
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDEF 401
Score = 99.4 bits (246), Expect = 1e-20
Identities = 48/122 (39%), Positives = 63/122 (51%), Gaps = 8/122 (6%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
C E C++G CI ++CDG +C+DGSDE + C+ +F CG C +
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE-LDCGPPPPCEPNEFPCGN--GHCALKL 341
Query: 87 WRCDGQVDCDNGSDEQGCPPK----TCSQDEFRC-HDGKCISRQFVCDSDRDCLDGSDEA 141
WRCDG DC++ +DE CP K C +FRC CI F CD + DC D SDE
Sbjct: 342 WRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEF 401
Query: 142 SC 143
C
Sbjct: 402 GC 403
Score = 66.6 bits (161), Expect = 9e-11
Identities = 33/82 (40%), Positives = 41/82 (50%), Gaps = 3/82 (3%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ--ETCLSVTCKSGDFSCGGRVNRCIP 84
CE NEF C +G C W CDG +C+D +DE+ C F C N CIP
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVS-TNMCIP 383
Query: 85 QFWRCDGQVDCDNGSDEQGCPP 106
+ CD + DC + SDE GC P
Sbjct: 384 ASFHCDEESDCPDRSDEFGCMP 405
Score = 53.9 bits (128), Expect = 6e-07
Identities = 40/141 (28%), Positives = 49/141 (34%), Gaps = 51/141 (36%)
Query: 236 CRPDEFQCSDGN-CIHGSRQCDREYDCKDMSDEVGCVNVTL------------------- 275
C EF C N C+ +CDR DC+DMSDE+ C L
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 276 --------------------------CEGPNKFKCHSGECITLDKVCNMARDCRDWSDE- 308
C GP + C +G CI D +C+ DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPC-GPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 309 ---PIKECGTNECLDNNGGCS 326
P C NE NG C+
Sbjct: 318 DCGPPPPCEPNEFPCGNGHCA 338
Score = 33.5 bits (75), Expect = 0.87
Identities = 48/221 (21%), Positives = 69/221 (31%), Gaps = 41/221 (18%)
Query: 51 ECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPP---- 106
+C G + TC+ SC G C P+ C G G + C P
Sbjct: 1139 DCDTGYTRTPSGLYLGTCER--CSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYG 1196
Query: 107 ---KTCSQDEFRCHDGKCISRQFVCDSDRDC-LDGSDEASCPVLTCGPASFQCNSSTCIP 162
+ QD C C + C LD +C + G + C C P
Sbjct: 1197 DAQRGTPQD---CQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCER--CAP 1251
Query: 163 QLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDC 222
+ G+ Q C Q DS +C + S +CD C
Sbjct: 1252 GYY----------GNPSQGQPC------QRDSQVPGPIGCNCDPQGSVSS--QCDAAGQC 1293
Query: 223 KDKSDEENCAVATCRPDEFQCSDGN--------CIHGSRQC 255
+ K+ E + CRP F S N C+ ++QC
Sbjct: 1294 QCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQC 1334
Score = 32.3 bits (72), Expect = 1.9
Identities = 40/134 (29%), Positives = 52/134 (38%), Gaps = 30/134 (22%)
Query: 310 IKECGTNECLDN---NGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDTC- 364
I C T C D NGG H + Y C+CP GF RCE P+ C
Sbjct: 3842 ISHCPT--CRDRPCQNGGQCH--DSESSSYVCVCPAGF---TGSRCEHSQALHCHPEACG 3894
Query: 365 -SQLCVNLEG--GYKC---------QCEEGFQLDPHTKACKAVGS-IAYLFFTNRHEVRK 411
CVN GY C +CEEG + T + GS +A TN H +
Sbjct: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVT--TPSLSGAGSYLALPALTNTHHELR 3952
Query: 412 MTLDRSEYTSLIPN 425
+ + E+ L P+
Sbjct: 3953 LDV---EFKPLAPD 3963
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 129 bits (324), Expect = 1e-29
Identities = 70/209 (33%), Positives = 112/209 (53%), Gaps = 7/209 (3%)
Query: 429 VVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNI 488
+V +D + +YW+D++ R I L+ + +T+++ + +P+GLA+D I +
Sbjct: 1144 IVGIDYDCRERMVYWTDVAGRTISRAGLELG---AEPETIVNSGLISPEGLAIDHIRRTM 1200
Query: 489 YWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPA-KIKKGGL 547
YWTDSVL + A G +RK LF + PRAI VDP+ G +YWTDW A KI+ L
Sbjct: 1201 YWTDSVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSL 1260
Query: 548 NGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAH 607
+G + L+ +I PNG+T D S L W D+ + +G R+ I + L +
Sbjct: 1261 DGENRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVI---QNNLKY 1317
Query: 608 PFSLAVFEDKVFWTDIINEAIFSANRLTG 636
PFS+ + D + TD + + S N+ +G
Sbjct: 1318 PFSIVSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 53.1 bits (126), Expect = 1e-06
Identities = 110/520 (21%), Positives = 173/520 (33%), Gaps = 96/520 (18%)
Query: 167 CDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG--------ECIH--SSWRC 216
CD C G+ C +QGD C E C +G CI+ S+RC
Sbjct: 770 CDTTARCHPGTGV-DYTCECASGYQGDGRNC-VDENECATGFHRCGPNSVCINLPGSYRC 827
Query: 217 DGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLC 276
+ + D C + T P C DG+ + C + + CV+
Sbjct: 828 ECRSGYEFADDRHTCILIT--PPANPCEDGS-----------HTCAP-AGQARCVH---- 869
Query: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGY 336
G + F C L C D + EC N C + C + +
Sbjct: 870 HGGSTFSC-----ACLPGYAGDGHQCTD-----VDECSENRCHP-----AATCYNTPGSF 914
Query: 337 ECLCP-----DGFQLVAQRR-----CED-----------------IDECQDPDTCSQL-C 368
C C DGFQ + CE I +C + L C
Sbjct: 915 SCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQYAYPGARFHIPQCDEQGNFLPLQC 974
Query: 369 VNLEGGYKCQCEEGFQLD--------------PHTKACKAVGSIAYLFFTNRHEVRKMTL 414
G C +G ++ P + + +I + N E T
Sbjct: 975 HGSTGFCWCVDPDGHEVPGTQTPPGSTPPHCGPSPEPTQRPPTICERWRENLLEHYGGTP 1034
Query: 415 DRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTV---ISR 471
+Y +L + + L S+ + D R + T+ + TV + R
Sbjct: 1035 RDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQGTRSQPGTTPACIPTVAPPMVR 1094
Query: 472 DIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVK--RKTLFRENGSKPRAIVVDPVHG 529
PD +Y +G + + T+ K KTL +GS I D
Sbjct: 1095 PTPRPDVTPPSVGTFLLYTQGQQIGYLPLNGTRLQKDAAKTLLSLHGSIIVGIDYDCRER 1154
Query: 530 FMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSID 589
+YWTD + G G + ++V + P G+ +D + +YW DS L I S
Sbjct: 1155 MVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTDSVLDKIESAL 1214
Query: 590 VNGGNRKTILEDEKRLAHPFSLAV--FEDKVFWTDIINEA 627
++G RK + + L +P ++AV ++WTD EA
Sbjct: 1215 LDGSERKVLFYTD--LVNPRAIAVDPIRGNLYWTDWNREA 1252
Score = 45.1 bits (105), Expect = 3e-04
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 21/97 (21%)
Query: 309 PIKECGT----NECLDNNGGCSHVCNDLK-------IGYECLCPDGFQLVAQRRCEDIDE 357
P+KE N C D SH+C+ + Y C C G+Q R C D +E
Sbjct: 750 PVKEDSDPTPGNPCYDG----SHMCDTTARCHPGTGVDYTCECASGYQGDG-RNCVDENE 804
Query: 358 CQDP-DTC--SQLCVNLEGGYKCQCEEGFQL--DPHT 389
C C + +C+NL G Y+C+C G++ D HT
Sbjct: 805 CATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
Score = 43.5 bits (101), Expect = 8e-04
Identities = 43/183 (23%), Positives = 65/183 (35%), Gaps = 25/183 (13%)
Query: 209 CIHSSWRCDGGPDCKDKSDEE-NCAVAT-CRPDEFQCSDGN-CIHGSRQCDREYDCKDMS 265
C S CD C + + C A+ + D C D N C G +C C ++
Sbjct: 763 CYDGSHMCDTTARCHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRCGPNSVCINLP 822
Query: 266 DEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGC 325
C C +F CI + N C D S G C+ + G
Sbjct: 823 GSYRCE----CRSGYEFADDRHTCILITPPAN---PCEDGS-HTCAPAGQARCVHHGGST 874
Query: 326 SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTC--SQLCVNLEGGYKCQCEEGF 383
+ C C G+ + C D+DEC + + C + C N G + C+C+ G+
Sbjct: 875 ----------FSCACLPGYAGDGHQ-CTDVDECSE-NRCHPAATCYNTPGSFSCRCQPGY 922
Query: 384 QLD 386
D
Sbjct: 923 YGD 925
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 128 bits (322), Expect = 2e-29
Identities = 67/154 (43%), Positives = 90/154 (58%), Gaps = 15/154 (9%)
Query: 31 EFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSG-DFSCGGRVNRCIPQFWRC 89
+F C+ G+CI + CDG A+C D SDE L+ +C +G F+C + C P FW C
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDE-----LNCSCDAGHQFTCKNKF--CKPLFWVC 508
Query: 90 DGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP---VL 146
D DC + SDEQGC +C FRC +GKC+S+ C+ DC DGSDEASCP V+
Sbjct: 509 DSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVV 565
Query: 147 TCGPASFQCNSSTCIPQ-LWACDNDPDCEDGSDE 179
TC +++C + C+ + CD DC DGSDE
Sbjct: 566 TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 103 bits (257), Expect = 7e-22
Identities = 73/233 (31%), Positives = 101/233 (43%), Gaps = 35/233 (15%)
Query: 101 EQGCPPKTCSQDEFRCHDGK-CISR-QFVCDSDRDCLDGSDEASCPVLTCG--------- 149
E G P TC +D + K C R QFV S+ + + + G
Sbjct: 389 EPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYD 448
Query: 150 -----PASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHC 204
P F C + CI + CD DC D SDE C + +F C
Sbjct: 449 SSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCD------------AGHQFTC 496
Query: 205 LSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM 264
+ C W CD DC D SDE+ C+ C F+CS+G C+ S+QC+ + DC D
Sbjct: 497 KNKFCKPLFWVCDSVNDCGDNSDEQGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDG 553
Query: 265 SDEVGC--VNVTLCEGPNKFKCHSGECITL-DKVCNMARDCRDWSDEPIKECG 314
SDE C VNV C + ++C +G C++ + C+ DC D SDE +CG
Sbjct: 554 SDEASCPKVNVVTCT-KHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605
Score = 89.4 bits (220), Expect = 1e-17
Identities = 47/128 (36%), Positives = 67/128 (52%), Gaps = 14/128 (10%)
Query: 30 NEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRC 89
++F C++ C WVCD +C D SDE +C + F C +C+ + +C
Sbjct: 492 HQFTCKNKFCKPLFWVCDSVNDCGDNSDEQ-----GCSCPAQTFRCSN--GKCLSKSQQC 544
Query: 90 DGQVDCDNGSDEQGCPP---KTCSQDEFRCHDGKCISR-QFVCDSDRDCLDGSDEASCPV 145
+G+ DC +GSDE CP TC++ +RC +G C+S+ CD DC DGSDE C
Sbjct: 545 NGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC-- 602
Query: 146 LTCGPASF 153
CG SF
Sbjct: 603 -DCGLRSF 609
Score = 62.4 bits (150), Expect = 2e-09
Identities = 35/96 (36%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 238 PDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCN 297
P +F C G CI +CD DC D SDE+ C C+ ++F C + C L VC+
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS----CDAGHQFTCKNKFCKPLFWVCD 509
Query: 298 MARDCRDWSDEPIKECGTNECLDNNGGC---SHVCN 330
DC D SDE C +NG C S CN
Sbjct: 510 SVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCN 545
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/84 (38%), Positives = 48/84 (57%), Gaps = 6/84 (7%)
Query: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS-VTCKSGDFSC--GGRVN 80
G C F+C +GKC+S C+G +C DGSDE+ ++ VTC + C G ++
Sbjct: 522 GCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLS 581
Query: 81 RCIPQFWRCDGQVDCDNGSDEQGC 104
+ P+ CDG+ DC +GSDE+ C
Sbjct: 582 KGNPE---CDGKEDCSDGSDEKDC 602
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 125 bits (314), Expect = 2e-28
Identities = 64/181 (35%), Positives = 97/181 (53%), Gaps = 6/181 (3%)
Query: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500
+YW+D I LD S T+I+ I PD +AV+W+ ++YWT + + V
Sbjct: 5 VYWTDDEVWAIRRAYLDG----SGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560
K L E+ +PRAI + P G YW DWG +IK+ L+ ++ LV ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
WPNG+ LDL G+LYW D+K I +I V+ R+T+L+D +L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKD--KLPHIFRFTLLGDFIYW 178
Query: 621 T 621
T
Sbjct: 179 T 179
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 125 bits (314), Expect = 2e-28
Identities = 64/181 (35%), Positives = 97/181 (53%), Gaps = 6/181 (3%)
Query: 441 IYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSV 500
+YW+D I LD S T+I+ I PD +AV+W+ ++YWT + + V
Sbjct: 5 VYWTDDEVWAIRRAYLDG----SGAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEV 60
Query: 501 ADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENI 560
K L E+ +PRAI + P G YW DWG +IK+ L+ ++ LV ++
Sbjct: 61 TCLNSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASL 120
Query: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
WPNG+ LDL G+LYW D+K I +I V+ R+T+L+D +L H F + D ++W
Sbjct: 121 GWPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKD--KLPHIFRFTLLGDFIYW 178
Query: 621 T 621
T
Sbjct: 179 T 179
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 101 bits (252), Expect = 3e-21
Identities = 118/441 (26%), Positives = 164/441 (37%), Gaps = 102/441 (23%)
Query: 25 DRCERNEFQCQDGKCISYKWVCDGSAECQ----DGSDESQETCLSVT-CKSGDFSCGGRV 79
D CERN C+ G C++ +GS +C S+E C+ + C D C R
Sbjct: 1160 DECERNPLLCRGGTCVN----TEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC--RN 1213
Query: 80 NRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD-GKCISRQFVCDSDRDCLDGS 138
+C+ G C Q P D C D +C+ CD+ +GS
Sbjct: 1214 GKCVNMI----GTYQCSCNPGYQATP------DRQGCTDIDECMIMNGGCDTQCTNSEGS 1263
Query: 139 DEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSD----EWPQRCRGLYVFQG-- 192
E SC + + +C + C+N+PD DG RC F
Sbjct: 1264 YECSCSE----GYALMPDGRSCA-DIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASM 1318
Query: 193 ------DSSPCSAFEFHCLSGECIHS--SWRCD---------GGPDCKDKSDEE----NC 231
D + C C+ GEC ++ S+ C G C D + E NC
Sbjct: 1319 DMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNC 1378
Query: 232 AV-ATCR--PDEFQCSD-----GN---------CIHGSRQCDREYDCKDM---------- 264
+ A+C P F+CS GN C +G+ QC C +
Sbjct: 1379 DMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSE 1438
Query: 265 ---SDEVGCVNVTLCEGPNKFKCHSGECITLDKV----CNM----ARDCRDWSDEPIKEC 313
D C +V C N C +G+C+ + C M A D R D
Sbjct: 1439 GFTGDGFTCSDVDEC-AENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQD------ 1491
Query: 314 GTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQR-RCEDIDECQDPDTC-SQLCVNL 371
+EC N CN+L + C+C DG++L C DIDEC DP C + LCVN
Sbjct: 1492 -IDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNT 1550
Query: 372 EGGYKCQCEEGFQLDPHTKAC 392
G Y+C C FQL+P C
Sbjct: 1551 PGRYECNCPPDFQLNPTGVGC 1571
Score = 97.4 bits (241), Expect = 5e-20
Identities = 113/485 (23%), Positives = 181/485 (37%), Gaps = 132/485 (27%)
Query: 25 DRCERNEFQCQDGKCI----SYKWVCDG-------SAECQDGSDESQETCLSVTCKS--G 71
D C N C +G C SY C + C+D ++ C++ C++ G
Sbjct: 812 DECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLG 871
Query: 72 DFSC----GGRVNR----CIPQF----W------RCDGQVD------------------- 94
F+C G +++ CI W RC+ ++
Sbjct: 872 SFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAAWGSP 931
Query: 95 CDNGSDEQGCPP-------------KTCSQDEFRCHDGKCISRQ--FVCD---------S 130
C+ + CP C C +G+C++ + F C+ +
Sbjct: 932 CERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPNGRCVNSKGSFHCECPEGLTLDGT 991
Query: 131 DRDCLD----------GSDEASCPVLTCGPASFQCNSSTC-IPQLWACDNDPDCEDGSDE 179
R CLD DE PV P F+ ++ C + W + + + G+ E
Sbjct: 992 GRVCLDIRMEQCYLKWDEDECIHPV----PGKFRMDACCCAVGAAWGTECEECPKPGTKE 1047
Query: 180 WPQRC--------RGLYV----FQGDSSPCSAFEFHCLSGECIHS--SWRCDGGPDCKDK 225
+ C RG + F D + C AF C G+C ++ S++C
Sbjct: 1048 YETLCPRGAGFANRGDVLTGRPFYKDINECKAFPGMCTYGKCRNTIGSFKCRCNSGFALD 1107
Query: 226 SDEENCA-VATCRPDEFQCSDGNCIH--GSRQCD--REYDCKDMSDEVGCVNVTLCEGPN 280
+E NC + CR C G C++ GS +C+ Y+ M + C+++ CE N
Sbjct: 1108 MEERNCTDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMK-NCMDIDECER-N 1165
Query: 281 KFKCHSGECITLD-----------KVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVC 329
C G C+ + ++ DC D I EC ++ L NG C ++
Sbjct: 1166 PLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVD-----INECSLSDNLCRNGKCVNMI 1220
Query: 330 NDLKIGYECLCPDGFQLVAQRR-CEDIDECQDPDT-CSQLCVNLEGGYKCQCEEGFQLDP 387
Y+C C G+Q R+ C DIDEC + C C N EG Y+C C EG+ L P
Sbjct: 1221 GT----YQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMP 1276
Query: 388 HTKAC 392
++C
Sbjct: 1277 DGRSC 1281
Score = 85.9 bits (211), Expect = 1e-16
Identities = 93/409 (22%), Positives = 152/409 (37%), Gaps = 61/409 (14%)
Query: 25 DRCERNEFQCQDGKCISYKWVCDGSAECQ--DGSDES---QETCLSVT-CKSGDFSCGGR 78
D C + C G C++ GS EC+ +G + + C+ + C+ C G
Sbjct: 1117 DECRISPDLCGSGICVN----TPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGG 1172
Query: 79 VNRCIPQFWRCDGQVDCDNGSDEQGCPP-KTCSQDEFRCHDGKCISRQFVCDSDRDCLDG 137
++CD + + + C CS + C +GKC++ + G
Sbjct: 1173 TCVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLCRNGKCVN-----------MIG 1221
Query: 138 SDEASC-PVLTCGPASFQCNS-STCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
+ + SC P P C C+ CD C + + C Y D
Sbjct: 1222 TYQCSCNPGYQATPDRQGCTDIDECMIMNGGCDTQ--CTNSEGSYECSCSEGYALMPDGR 1279
Query: 196 PCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA----------------VATCRPD 239
C+ + EC ++ CDGG C + E C V C +
Sbjct: 1280 SCADID------ECENNPDICDGG-QCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLN 1332
Query: 240 EFQCSDGNCIH--GSRQCDREYDCKDMSDEVGCVNVTLCE-GPNKFKCHSGECITLDKVC 296
C G C + GS C + GC +V CE G + H+ C+ +
Sbjct: 1333 SNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHAS-CLNIPG-- 1389
Query: 297 NMARDCRD-WSDEPIKECGTNECLDNNGGCS--HVCNDLKIGYECLCPDGFQLVAQRRCE 353
+ CR+ W IK +EC + CS C + Y C C +GF C
Sbjct: 1390 SFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSEGFTGDGFT-CS 1448
Query: 354 DIDEC-QDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAY 400
D+DEC ++ + C C+N+ G Y+C+CE GF +++C+ + ++
Sbjct: 1449 DVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQDIDECSF 1497
Score = 83.6 bits (205), Expect = 7e-16
Identities = 123/537 (22%), Positives = 178/537 (33%), Gaps = 141/537 (26%)
Query: 58 ESQETCLSVT-CKSGDFSCGGRVNRC--IPQFWRCDGQVDCDNGSDEQGCPPKT-CSQDE 113
E Q+ C + C G C R C + + C D +GC + C
Sbjct: 2287 EDQKMCKDLDECAEGLHDCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKP 2346
Query: 114 FRCHDGKCIS--RQFVCD---------SDRDCLDGSDEASCPVLTCGPASFQCNSSTCIP 162
C +G+C++ + C+ S +CLD + C +SS +
Sbjct: 2347 GICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNR-QGLCFAEVLQTICQMASSSRNLV 2405
Query: 163 QLWACDNDPDCEDGSDEWPQRCR------------------GLYVFQGDSSPCSAFEFHC 204
C C DG W +C G D C C
Sbjct: 2406 TKSEC-----CCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDIDECKVMPNLC 2460
Query: 205 LSGECIHS--SWRCD---------GGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSR 253
+G+CI++ S+RC G C D + C+ + +P + C + GS
Sbjct: 2461 TNGQCINTMGSFRCFCKVGYTTDISGTSCIDLDE---CSQSP-KPCNYICKN---TEGSY 2513
Query: 254 QCD--REY-------DCKDMSD--------EVGCVNVT---LCEGPNKFKCH------SG 287
QC R Y CKD+ + + CVN C+ P F H +
Sbjct: 2514 QCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFTQHHTACIDNN 2573
Query: 288 ECITLDKVCNMARDCRDWSDEPIKEC--------------GTNECLDNNGGCSHVCNDLK 333
EC + +C C++ EC +EC D N C H C ++
Sbjct: 2574 ECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNHRCQHGCQNIL 2632
Query: 334 IGYECLCPDGF-QLVAQRRCEDIDECQDPDTC-SQLCVNLEGGYKCQCEEGFQLDPHTKA 391
GY C CP G+ Q +C D +EC +P+ C S C N G YKC C GF D + A
Sbjct: 2633 GGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSSA 2692
Query: 392 CKAVGSIA------------------------YLFFTNRHEVRKMTLDRSEYTSLIPNLR 427
C V + Y H V M ++ +Y S
Sbjct: 2693 CHDVNECSSSKNPCNYGCSNTEGGYLCGCPPGYYRVGQGHCVSGMGFNKGQYLS------ 2746
Query: 428 NVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWI 484
LDTEV + + +G S D+ R I PD AV+ I
Sbjct: 2747 ----LDTEVDEENALSPEACYEC-------KINGYSKKDSRQKRSIHEPDPTAVEQI 2792
Score = 80.5 bits (197), Expect = 6e-15
Identities = 101/409 (24%), Positives = 150/409 (36%), Gaps = 89/409 (21%)
Query: 25 DRCERNEFQCQDGKCI----SYKWVCD-GSAECQDGSDESQETCLSVTCKSGDFSCGGRV 79
D C+ + C +G+CI SY+ C+ G + +G + C S C +GD
Sbjct: 496 DICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNPCTNGD------- 548
Query: 80 NRCI--PQFWRCDGQVDCDNGSDEQGCPP-KTCSQDEFRCHDGKCI----SRQFVCDSD- 131
C+ P + C +Q C C Q+ C +G+C+ S Q +C++
Sbjct: 549 --CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGF 606
Query: 132 ------RDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCR 185
++C+D + + + G + S CI C+ G P
Sbjct: 607 ELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCI-----------CKPGFVLAPN--- 652
Query: 186 GLYVFQGDSSPCSAFEFHCLSGECIHS--SWRCDGGPDCKDKSDEENCAVATCRPDEFQC 243
G Y D C++G CI+S S+RCD P D C R
Sbjct: 653 GRYCTDVDECQTPGI---CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMR------ 703
Query: 244 SDGNCIHGSRQ--CDREYDCKDMSDEVGCVNVTL--------CEGPNKFK----CHSGEC 289
C G ++ C R + E C N C N + C SG
Sbjct: 704 --STCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVG 761
Query: 290 ITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ 349
IT+D RD I EC + + NG +C +L+ Y C C G++ A
Sbjct: 762 ITVD-----GRD--------INECALDPDICANG----ICENLRGSYRCNCNSGYEPDAS 804
Query: 350 -RRCEDIDECQ-DPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKACKAV 395
R C DIDEC + C LC N G Y C C G+ T+ C+ +
Sbjct: 805 GRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDI 853
Score = 79.3 bits (194), Expect = 1e-14
Identities = 109/413 (26%), Positives = 155/413 (37%), Gaps = 87/413 (21%)
Query: 25 DRCERNEFQCQDGKCI----SYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVN 80
D CER+ C +G C SY +C E +D CL + S F R
Sbjct: 1936 DECERHP--CGNGTCKNTVGSYNCLCYPGFELTHNND-----CLDIDECSSFFGQVCRNG 1988
Query: 81 RCIPQF--WRC----------DGQVDCDNGSDEQ---GCPPKTCSQDE--FRC------- 116
RC + ++C DG+ D C P TC E FRC
Sbjct: 1989 RCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCICPPGYE 2048
Query: 117 -HDGKCISRQFVCDSDRD-CLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE 174
CI CD D + CL GS T P FQC C P DN C
Sbjct: 2049 VKSENCIDIN-ECDEDPNICLFGS-------CTNTPGGFQC---LCPPGFVLSDNGRRCF 2097
Query: 175 DGSDEWPQRCRGLYVFQG-DSSPCSAFE-FHCLSGECIHSSWRCDG-GPDCKDKSDEENC 231
D R + F ++ CS + F+ +C S +G G C+
Sbjct: 2098 D--------TRQSFCFTNFENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCE-------- 2141
Query: 232 AVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECIT 291
C D+ C +G +D ++ +E C+ E P C +G+CI
Sbjct: 2142 ---LCPKDDEVAFQDLCPYGHGTVPSLHDTREDVNE--CL-----ESPGI--CSNGQCIN 2189
Query: 292 LDKV----CNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLV 347
D C M + D++ ++ T+EC N + C ++ +EC C +GF+
Sbjct: 2190 TDGSFRCECPMGYNL-DYTG--VRCVDTDECSIGNPCGNGTCTNVIGSFECNCNEGFEPG 2246
Query: 348 AQRRCEDIDEC-QDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIA 399
CEDI+EC Q+P C+ C+N G Y+C C G+ L K CK + A
Sbjct: 2247 PMMNCEDINECAQNPLLCAFRCMNTFGSYECTCPIGYALREDQKMCKDLDECA 2299
Score = 73.9 bits (180), Expect = 6e-13
Identities = 106/444 (23%), Positives = 158/444 (35%), Gaps = 101/444 (22%)
Query: 25 DRCERNEFQCQDGKCI----SYKWVCDGSAECQ-DGS-----DESQET--CLSVTC--KS 70
D C +N C++G+C+ S++ +C+ E DG DE T CL+ C +
Sbjct: 577 DECIQNGVLCKNGRCVNTDGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINED 636
Query: 71 GDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQ--FVC 128
G F C C P F V NG + C Q C +G CI+ + F C
Sbjct: 637 GSFKC-----ICKPGF------VLAPNG---RYCTDVDECQTPGICMNGHCINSEGSFRC 682
Query: 129 D---------SDRDCLDGSDEASC-----PVLTCGPASFQCNSSTCIPQLWACDNDPDCE 174
D R C+D ++C + P S C C +PD
Sbjct: 683 DCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSEC------CCANPDYG 736
Query: 175 DGSDEWPQRCRGLYVFQG-------------DSSPCSAFEFHCLSGEC--IHSSWRCDGG 219
G P + F G D + C+ C +G C + S+RC+
Sbjct: 737 FGEPCQPCPAKNSAEFHGLCSSGVGITVDGRDINECALDPDICANGICENLRGSYRCNCN 796
Query: 220 PDCKDKSDEENCA-VATCRPDEFQCSDGNCIH--GSRQCD---------REYDCKDMSD- 266
+ + NC + C + C +G C + GS C C+D+++
Sbjct: 797 SGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETETCEDINEC 856
Query: 267 -EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRD------WSDEPIKECGTN--- 316
CVN F C EC K+ + C D W + C N
Sbjct: 857 ESNPCVNGACRNNLGSFNC---ECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCEVNING 913
Query: 317 -----ECLDNNGGC-SHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDTC-SQLC 368
EC G C ++ + CP G + CED++EC+ P C + C
Sbjct: 914 ATLKSECCATLGAAWGSPCERCEL--DTACPRGLARIKGVTCEDVNECEVFPGVCPNGRC 971
Query: 369 VNLEGGYKCQCEEGFQLDPHTKAC 392
VN +G + C+C EG LD + C
Sbjct: 972 VNSKGSFHCECPEGLTLDGTGRVC 995
Score = 73.2 bits (178), Expect = 1e-12
Identities = 60/216 (27%), Positives = 90/216 (41%), Gaps = 49/216 (22%)
Query: 186 GLYVFQGDSSPCSAFEFHCLSGECIH--SSWRCDGGPDCKDKSDEENCAVATCRPDEFQC 243
GL + C CL+G CI SS+RC+ K ++ + V C + C
Sbjct: 487 GLTILNQTIDICKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--C 544
Query: 244 SDGNCIH--GSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD 301
++G+C++ GS C KCH+G T K +
Sbjct: 545 TNGDCVNTPGSYYC---------------------------KCHAGFQRTPTK-----QA 572
Query: 302 CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQD 360
C D I EC N L NG C + ++C+C GF+L + C D DEC
Sbjct: 573 CID-----IDECIQNGVLCKNGRCVNTDGS----FQCICNAGFELTTDGKNCVDHDECTT 623
Query: 361 PDTC-SQLCVNLEGGYKCQCEEGFQLDPHTKACKAV 395
+ C + +C+N +G +KC C+ GF L P+ + C V
Sbjct: 624 TNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDV 659
Score = 68.9 bits (167), Expect = 2e-11
Identities = 58/215 (26%), Positives = 81/215 (37%), Gaps = 46/215 (21%)
Query: 193 DSSPCSAFEFHCLSGECIHS--SWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIH 250
D C C +G CI+ S+RC+ C + + DE C +
Sbjct: 1808 DIDECKEIPGICANGVCINQIGSFRCE----CPTGFSYNDLLLVCEDIDE-------CSN 1856
Query: 251 GSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPI 310
G C R DC P ++C EC K+ P
Sbjct: 1857 GDNLCQRNADC--------------INSPGSYRC---ECAAGFKL------------SPN 1887
Query: 311 KEC-GTNECLDNNGGCSH-VCNDLKIGYECLCPDGFQLVA-QRRCEDIDECQDPDTCSQL 367
C NECL+ CSH +C DL+ Y+C+C +GF+ Q C D+DEC+ +
Sbjct: 1888 GACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQTMCMDVDECERHPCGNGT 1947
Query: 368 CVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLF 402
C N G Y C C GF+L H C + + F
Sbjct: 1948 CKNTVGSYNCLCYPGFEL-THNNDCLDIDECSSFF 1981
Score = 65.1 bits (157), Expect = 3e-10
Identities = 103/434 (23%), Positives = 153/434 (35%), Gaps = 88/434 (20%)
Query: 25 DRCERNEFQCQDGKCIS----YKWVC-DGSAECQDGSDESQETCLSVTCKSGDFSCGGRV 79
D CE N C G+C + Y+ +C DG D +TC+ V C
Sbjct: 1285 DECENNPDICDGGQCTNIPGEYRCLCYDGFMASMD-----MKTCIDVN------ECDLNS 1333
Query: 80 NRCIPQFWRCDGQVDCDNGSDEQGCP-PKTCSQDEFRCHD-GKCISRQFVCDSDRDCLD- 136
N C+ F C+ GS C + + C D +C CD CL+
Sbjct: 1334 NICM--FGECENT----KGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNI 1387
Query: 137 -GSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSS 195
GS + SC G + C C + C + + RC F GD
Sbjct: 1388 PGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGSY--RCACSEGFTGDGF 1445
Query: 196 PCSAFEFH------CLSGECIH--SSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN 247
CS + C +G+C++ ++RC+ SD +C D +CS N
Sbjct: 1446 TCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQ------DIDECSFQN 1499
Query: 248 -CIHGSRQ---------CDREYD-------CKDM---SDEVGCVNVTLCEGPNKFKCHSG 287
C+ G+ CD Y+ C D+ +D + CVN P +++C+
Sbjct: 1500 ICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDECADPINCVNGLCVNTPGRYECNCP 1559
Query: 288 ECITLDK-----VCNMARDCR-------DWSDEPIKECGTNE-----CLDNNGGCSHVCN 330
L+ V N +C D S E G C + C
Sbjct: 1560 PDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCCCSLGKAWGNPCE 1619
Query: 331 DL----KIGYECLCPDGFQLVAQRRC---EDIDECQD-PDTCSQ-LCVNLEGGYKCQCEE 381
Y LCP G EDIDECQ+ P C C+N G ++C+C +
Sbjct: 1620 TCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQELPGLCQGGNCINTFGSFQCECPQ 1679
Query: 382 GFQLDPHTKACKAV 395
G+ L T+ C+ +
Sbjct: 1680 GYYLSEDTRICEDI 1693
Score = 53.5 bits (127), Expect = 8e-07
Identities = 67/280 (23%), Positives = 92/280 (32%), Gaps = 49/280 (17%)
Query: 143 CPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGD-SSPCSAFE 201
CP P QC +P C N C DG P C G SS C +
Sbjct: 98 CPGWKTLPGGNQC----IVP---ICRNS--CGDGFCSRPNMCT---CSSGQISSTCGSKS 145
Query: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN---------CIHG- 251
S C++ D C+ C C E C +G C++G
Sbjct: 146 IQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVC---ENGCQNGGRCIGPNRCACVYGF 202
Query: 252 -SRQCDREYD------------CKDMSDEVGCVNVTLCEGPNKFKCHSGE-CITLDKVCN 297
QC+R+Y C+ + C C + H E C + C
Sbjct: 203 TGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQPQPCR 262
Query: 298 MA--RDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGF-QLVAQRRCED 354
+ R + + + EC + G C + +EC CP G Q ++CED
Sbjct: 263 RGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGS----FECRCPAGHKQSETTQKCED 318
Query: 355 IDECQ-DPDTC-SQLCVNLEGGYKCQCEEGFQLDPHTKAC 392
IDEC P C + C N G Y C C G+ C
Sbjct: 319 IDECSIIPGICETGECSNTVGSYFCVCPRGYVTSTDGSRC 358
Score = 46.6 bits (109), Expect = 1e-04
Identities = 62/251 (24%), Positives = 89/251 (35%), Gaps = 57/251 (22%)
Query: 189 VFQGDSSPCSAFEFHCLSGECIHSSWRC-DGGPDCKDKSDEENCAVATC-RPDEFQCSDG 246
V +G + S F +C G W+ GG C +C C RP+ CS G
Sbjct: 82 VLRGPNVCGSRFHSYCCPG------WKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSG 135
Query: 247 N----------------CIHGSR------QCDREYD---CKDMSDEVGCVNVTLCEGPNK 281
C++G QC + Y C E GC N C GPN+
Sbjct: 136 QISSTCGSKSIQQCSVRCMNGGTCADDHCQCQKGYIGTYCGQPVCENGCQNGGRCIGPNR 195
Query: 282 FKC-------------HSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGC-SH 327
C +G C T +V N C+ + C C G H
Sbjct: 196 CACVYGFTGPQCERDYRTGPCFT--QVNNQM--CQGQLTGIV--CTKTLCCATIGRAWGH 249
Query: 328 VCNDLKIGYECLCPDGF-QLVAQRRCEDIDECQD-PDTCSQ-LCVNLEGGYKCQCEEGFQ 384
C ++ C GF + C+D+DECQ P C C+N G ++C+C G +
Sbjct: 250 PC-EMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHK 308
Query: 385 LDPHTKACKAV 395
T+ C+ +
Sbjct: 309 QSETTQKCEDI 319
>gi|110347457 EGF-like-domain, multiple 3 [Homo sapiens]
Length = 1541
Score = 100 bits (249), Expect = 6e-21
Identities = 87/329 (26%), Positives = 124/329 (37%), Gaps = 59/329 (17%)
Query: 100 DEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSST 159
DE+GC CS H G+C+ + CP GP Q +
Sbjct: 119 DEEGCLSAECSAS-LCFHGGRCVP------------GSAQPCHCPPGFQGPRC-QYDVDE 164
Query: 160 CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL-SGECIH------- 211
C C + C + + C+ + DS C A L +G C H
Sbjct: 165 CRTHNGGCQHR--CVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTI 222
Query: 212 SSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIH------GSRQCDREYDCKDMS 265
+ RC P + + D +C R +G+C+H G +C+ + +
Sbjct: 223 TRHRCQCRPGFQLQEDGRHCV----RRSPCANRNGSCMHRCQVVRGLARCECHVGYQLAA 278
Query: 266 DEVGCVNVTLC--------------EGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIK 311
D C +V C +G K CH+G + D R C E +
Sbjct: 279 DGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGAD-----GRQCYRIEMEIV- 332
Query: 312 ECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDECQDPDTCSQLCVN 370
N C NNGGCSH C+ G C CP G++L QR C D+D+C D C Q+C N
Sbjct: 333 ----NSCEANNGGCSHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPCCQQVCTN 388
Query: 371 LEGGYKCQCEEGFQLDPHTKACKAVGSIA 399
GGY+C C G++L C+ V A
Sbjct: 389 NPGGYECGCYAGYRLSADGCGCEDVDECA 417
Score = 46.2 bits (108), Expect = 1e-04
Identities = 99/415 (23%), Positives = 134/415 (32%), Gaps = 114/415 (27%)
Query: 46 CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP 105
C S CQ+G TC S +C RC P + + C G + C
Sbjct: 564 CSFSCSCQNGG----------TCDSVTGAC-----RCPPGVSGTNCEDGCPKGYYGKHCR 608
Query: 106 PKTCSQDEFRCHD--GKCISRQFVCDSD---RDCLDGSDEASCPVLTCGPA-SFQCNSST 159
K + RCH G C+ CD R C +CP GP S +C
Sbjct: 609 KKCNCANRGRCHRLYGACL-----CDPGLYGRFC-----HLTCPPWAFGPGCSEECQ--- 655
Query: 160 CI-PQLWACDN-DPDCEDGSDEWPQRCRGL----YVFQGDSSPCSA---FEFHCLSGECI 210
C+ P +CD D C + +RC+ Y G C+ +SGEC
Sbjct: 656 CVQPHTQSCDKRDGSCSCKAGFRGERCQAECELGYFGPGCWQACTCPVGVACDSVSGEC- 714
Query: 211 HSSWRCDGG---PDCKDK----------SDEENCAVATCRPDEFQCSDGNCIHGSRQCDR 257
RC G DC + S +C A C QC C G D
Sbjct: 715 --GKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQC---RCPPGRTGEDC 769
Query: 258 EYDCKDMSDEVGCVNVT-LCEGPNKFKCHSGECITLDKVCNMARDCRD-----WSDEPIK 311
E DC + +GC + C+ + +G C+ L + C+D W
Sbjct: 770 EADCPEGRWGLGCQEICPACQHAARCDPETGACLCLPGF--VGSRCQDVCPAGWYGP--- 824
Query: 312 ECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ-LVAQRRCEDID---ECQDPDTCSQ- 366
C T N+G C C C G+ QR C+ +C P CS
Sbjct: 825 SCQTRCSCANDGHCHPATG------HCSCAPGWTGFSCQRACDTGHWGPDCSHPCNCSAG 878
Query: 367 ---------LCVNLEGGY--------------------KCQCEEGFQLDPHTKAC 392
LC+ E GY +CQC+ G D + AC
Sbjct: 879 HGSCDAISGLCL-CEAGYVGPRCEQQCPQGHFGPGCEQRCQCQHGAACDHVSGAC 932
Score = 44.3 bits (103), Expect = 5e-04
Identities = 90/386 (23%), Positives = 127/386 (32%), Gaps = 105/386 (27%)
Query: 40 ISYKWVCDGSA-----ECQDGSDESQETCLSVTCKSGDFSC--------GGRVNRCIPQF 86
+ Y+ DG A EC G + CL+ G F C G +C
Sbjct: 272 VGYQLAADGKACEDVDECAAGLAQCAHGCLNT---QGSFKCVCHAGYELGADGRQCYRIE 328
Query: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSD-RDCLDGSDEASCPV 145
+ +NG GC T + C G + D+D R C+D D
Sbjct: 329 MEIVNSCEANNGGCSHGCS-HTSAGPLCTCPRG------YELDTDQRTCIDVDD------ 375
Query: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCL 205
C S C Q+ C N+P + C Y D C +
Sbjct: 376 ---------CADSPCCQQV--CTNNPGGYECG------CYAGYRLSADGCGCEDVD---- 414
Query: 206 SGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMS 265
EC S C E +C T FQCS C G R + C +
Sbjct: 415 --ECASSRGGC-----------EHHC---TNLAGSFQCS---CEAGYRLHEDRRGCSPLE 455
Query: 266 DEVGCVNVTLCEGPNKFKCHSGECITL-DKVCNMARDCRDWSDEPIKECGTNE------- 317
+ + V L +G F L D++ + +D +DE E
Sbjct: 456 EPM----VDL-DGELPFVRPLPHIAVLQDELPQLFQDDDVGADEEEAELRGEHTLTEKFV 510
Query: 318 CLDNNGG--CSHVCNDLKIGYECL-------CPDGFQ-LVAQRRCEDIDECQDPDTCSQL 367
CLD++ G CS C+D + G CL CP+G+ L+ C PDT +
Sbjct: 511 CLDDSFGHDCSLTCDDCRNGGTCLLGLDGCDCPEGWTGLICNETCP-------PDTFGKN 563
Query: 368 CVNLEGGYKCQCEEGFQLDPHTKACK 393
C + C C+ G D T AC+
Sbjct: 564 C-----SFSCSCQNGGTCDSVTGACR 584
Score = 38.5 bits (88), Expect = 0.027
Identities = 87/400 (21%), Positives = 117/400 (29%), Gaps = 93/400 (23%)
Query: 24 GDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQ------ETCLSVTCKSGDFS--- 74
GD+C+ + G+ + + C A C + + + C G F
Sbjct: 1112 GDKCQSPCLRGWFGEACAQRCSCPPGAACHHVTGACRCPPGFTGSGCEQACPPGSFGEDC 1171
Query: 75 -----CGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPP----KTCSQDEFRCHDGKCISRQ 125
C G C P C S +Q CPP C Q + G C +
Sbjct: 1172 AQMCQCPGENPACHPATGTCSCAAGYHGPSCQQRCPPGRYGPGCEQLCGCLNGGSCDAAT 1231
Query: 126 FVCDSDRDCLDGSDEASCPVLTCGP-ASFQC---NSSTCIPQLWACDNDPD-----CEDG 176
C L +CP GP + C + C P C P CE G
Sbjct: 1232 GACRCPTGFLGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGRAGVRCERG 1291
Query: 177 SDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATC 236
PQ G+ G CS C +G H+S +G C +C +A C
Sbjct: 1292 C---PQNRFGV----GCEHTCS-----CRNGGLCHAS---NGSCSCGLGWTGRHCELA-C 1335
Query: 237 RPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC---VNVTLCEGPNKFKCHSGECITLD 293
P + G H C C+ + C CE P H C
Sbjct: 1336 PPGRY----GAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGC---Q 1388
Query: 294 KVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ-LVAQRRC 352
+C W C H I CLCP GF +R C
Sbjct: 1389 GLC--------W-------------------CQHGAPCDPISGRCLCPAGFHGHFCERGC 1421
Query: 353 EDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKAC 392
E P + + C +C C+ G DP T C
Sbjct: 1422 E-------PGSFGEGC-----HQRCDCDGGAPCDPVTGLC 1449
Score = 38.5 bits (88), Expect = 0.027
Identities = 70/279 (25%), Positives = 89/279 (31%), Gaps = 61/279 (21%)
Query: 46 CD---GSAECQDGSDESQETCLSVTCKSGDFS------CG-GRVNRCIPQFWRCDGQVDC 95
CD G+ C G T ++TC G F CG G+ C P C
Sbjct: 1227 CDAATGACRCPTGF---LGTDCNLTCPQGRFGPNCTHVCGCGQGAACDPVTGTCLCPPGR 1283
Query: 96 DNGSDEQGCPPK--------TCSQDEFRCHDGK-CISRQFVCDSDRDCLDGSDEASCPVL 146
E+GCP TCS C +G C + C E +CP
Sbjct: 1284 AGVRCERGCPQNRFGVGCEHTCS-----CRNGGLCHASNGSCSCGLGWTGRHCELACPPG 1338
Query: 147 TCGPAS-FQC---NSSTCIPQLWACDNDPDCEDGSDEWP-------QRCRGLYVFQGDSS 195
G A +C N+STC P C P + E P C+GL Q +
Sbjct: 1339 RYGAACHLECSCHNNSTCEPATGTCRCGPGFYGQACEHPCPPGFHGAGCQGLCWCQ-HGA 1397
Query: 196 PCSAFEFHCLS------------------GECIHSSWRCDGGPDCKDKSDEENC----AV 233
PC CL GE H CDGG C + C +
Sbjct: 1398 PCDPISGRCLCPAGFHGHFCERGCEPGSFGEGCHQRCDCDGGAPCDPVTGLCLCPPGRSG 1457
Query: 234 ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVN 272
ATC D + G C DC +S + CV+
Sbjct: 1458 ATCNLDCRRGQFGPSCTLHCDCGGGADCDPVSGQCHCVD 1496
Score = 33.1 bits (74), Expect = 1.1
Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 6/39 (15%)
Query: 674 NGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
NGGCQ+ C+ P + C C G L D R+CL
Sbjct: 169 NGGCQHRCVNTP------GSYLCECKPGFRLHTDSRTCL 201
Score = 30.4 bits (67), Expect = 7.3
Identities = 19/55 (34%), Positives = 25/55 (45%), Gaps = 9/55 (16%)
Query: 664 VNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
VN CE +NGGC + C + S C CP G L D R+C+ + A
Sbjct: 332 VNSCEA---NNGGCSHGC------SHTSAGPLCTCPRGYELDTDQRTCIDVDDCA 377
Score = 30.0 bits (66), Expect = 9.6
Identities = 19/55 (34%), Positives = 24/55 (43%), Gaps = 8/55 (14%)
Query: 664 VNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAA 718
+N C L NGGCQ+ C+ I H C C G L D R C+ + A
Sbjct: 203 INSC---ALGNGGCQHHCVQL-TITRH----RCQCRPGFQLQEDGRHCVRRSPCA 249
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 99.8 bits (247), Expect = 1e-20
Identities = 107/417 (25%), Positives = 150/417 (35%), Gaps = 107/417 (25%)
Query: 8 LRWTVALLLAAA------------GTAVGDRCERNEFQCQ-DGKCI----SYKWVCDGSA 50
+RW + +LLA G+ D C C D C SYK +C
Sbjct: 6 VRWHLCVLLALGTRGRLAGGSGLPGSVDVDECSEGTDDCHIDAICQNTPKSYKCLCKPGY 65
Query: 51 ECQDGSDESQETCLSVTCKSGDFSCGGRVNRCI--PQFWRC----------DGQ--VDCD 96
+ + E + C D+ GG V+ CI P +RC DG +D D
Sbjct: 66 KGEGKQCEDIDEC------ENDYYNGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVD 119
Query: 97 NGSDEQGCPPKTC--SQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQ 154
D G + C + + C +C S F+ D+ C+ S+E + C
Sbjct: 120 ECQDNNGGCQQICVNAMGSYEC---QCHSGFFLSDNQHTCIHRSNEG----MNCMNKDHG 172
Query: 155 CNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSW 214
C C P D CR + + C+ + +G C HS
Sbjct: 173 CAH--------ICRETPKGGVACD-----CRPGFDLAQNQKDCT-LTCNYGNGGCQHSCE 218
Query: 215 RCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN-----CIHGSRQCDREYDCKDMSDEVG 269
D GP C C SDG C + CDR CKD + V
Sbjct: 219 DTDTGPTCG------------CHQKYALHSDGRTCIETCAVNNGGCDRT--CKDTATGVR 264
Query: 270 CVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVC 329
C C G + D + C+D NECL NNGGC H C
Sbjct: 265 C------------SCPVGFTLQPD-----GKTCKD----------INECLVNNGGCDHFC 297
Query: 330 NDLKIGYECLCPDGFQLVA-QRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQL 385
+ +EC C G++L+ +R C+DIDEC TC +C+N G ++C C G+ L
Sbjct: 298 RNTVGSFECGCRKGYKLLTDERTCQDIDECSFERTCDHICINSPGSFQCLCHRGYIL 354
Score = 78.6 bits (192), Expect = 2e-14
Identities = 50/150 (33%), Positives = 68/150 (45%), Gaps = 21/150 (14%)
Query: 246 GNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEG-PNKFKCHSGECITLDKVCNMARDCRD 304
G+ + GS D +C + +D+ C +C+ P +KC +C
Sbjct: 25 GSGLPGSVDVD---ECSEGTDD--CHIDAICQNTPKSYKC----------LCKPGYKGEG 69
Query: 305 WSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQ-RRCEDIDECQDPDT 363
E I EC + NGGC H C ++ Y C C DGF L C D+DECQD +
Sbjct: 70 KQCEDIDECENDYY---NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNG 126
Query: 364 -CSQLCVNLEGGYKCQCEEGFQLDPHTKAC 392
C Q+CVN G Y+CQC GF L + C
Sbjct: 127 GCQQICVNAMGSYECQCHSGFFLSDNQHTC 156
Score = 73.2 bits (178), Expect = 1e-12
Identities = 72/310 (23%), Positives = 119/310 (38%), Gaps = 58/310 (18%)
Query: 133 DCLDGSDEASCPVLTCG-PASFQCNSSTCIPQLWA----CDNDPDCEDGSDEWPQRCRGL 187
+C +G+D+ + P S++C C P C++ +CE+ D + C
Sbjct: 36 ECSEGTDDCHIDAICQNTPKSYKC---LCKPGYKGEGKQCEDIDECEN--DYYNGGCVHE 90
Query: 188 YVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDE-ENCAVATCRPDEFQCSDG 246
+ + C+ F+ L+ H C +C+D + + V E QC G
Sbjct: 91 CINIPGNYRCTCFDGFMLA----HDGHNCLDVDECQDNNGGCQQICVNAMGSYECQCHSG 146
Query: 247 --------NCIHGSRQCDREYDCKDMSDEVGCVNVT--LCEGPNKFKCHSGECITLDK-- 294
CIH S + +C M+ + GC ++ +G C G + ++
Sbjct: 147 FFLSDNQHTCIHRSNE---GMNC--MNKDHGCAHICRETPKGGVACDCRPGFDLAQNQKD 201
Query: 295 ---VCNMAR-----DCRDWSDEPIKECGTNE--------------CLDNNGGCSHVCNDL 332
CN C D P CG ++ C NNGGC C D
Sbjct: 202 CTLTCNYGNGGCQHSCEDTDTGPT--CGCHQKYALHSDGRTCIETCAVNNGGCDRTCKDT 259
Query: 333 KIGYECLCPDGFQLVAQ-RRCEDIDECQ-DPDTCSQLCVNLEGGYKCQCEEGFQLDPHTK 390
G C CP GF L + C+DI+EC + C C N G ++C C +G++L +
Sbjct: 260 ATGVRCSCPVGFTLQPDGKTCKDINECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDER 319
Query: 391 ACKAVGSIAY 400
C+ + ++
Sbjct: 320 TCQDIDECSF 329
Score = 33.5 bits (75), Expect = 0.87
Identities = 15/39 (38%), Positives = 20/39 (51%), Gaps = 6/39 (15%)
Query: 674 NGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCL 712
NGGC + C+ P + C C DG +LA D +CL
Sbjct: 84 NGGCVHECINIPG------NYRCTCFDGFMLAHDGHNCL 116
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 99.4 bits (246), Expect = 1e-20
Identities = 46/114 (40%), Positives = 61/114 (53%), Gaps = 3/114 (2%)
Query: 32 FQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG 91
F C +G+CI W CDG +C D SDE + C F C ++ CI +RC+G
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIH-CIIGRFRCNG 93
Query: 92 QVDCDNGSDEQGCP--PKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
DC +GSDE+ C P CS + C +G CI + F+CD +C D SDE SC
Sbjct: 94 FEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 95.1 bits (235), Expect = 2e-19
Identities = 51/124 (41%), Positives = 62/124 (50%), Gaps = 11/124 (8%)
Query: 150 PASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSG-E 208
P +F C++ CIP W CD PDC D SDE + C S C F C SG
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC------PKAKSKCGPTFFPCASGIH 83
Query: 209 CIHSSWRCDGGPDCKDKSDEENCAV--ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
CI +RC+G DC D SDEENC C + C +G CI S CD + +C+D SD
Sbjct: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSD 143
Query: 267 EVGC 270
E C
Sbjct: 144 EESC 147
Score = 94.4 bits (233), Expect = 4e-19
Identities = 50/121 (41%), Positives = 63/121 (52%), Gaps = 11/121 (9%)
Query: 114 FRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLT--CGPASFQCNSST-CIPQLWACDND 170
F C +G+CI + CD DC D SDE CP CGP F C S CI + C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 171 PDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEEN 230
DC DGSDE + C + CS +HC +G CI S+ CDG +C+D SDEE+
Sbjct: 95 EDCPDGSDE--ENCTANPLL------CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 231 C 231
C
Sbjct: 147 C 147
Score = 92.4 bits (228), Expect = 2e-18
Identities = 46/110 (41%), Positives = 62/110 (56%), Gaps = 3/110 (2%)
Query: 202 FHCLSGECIHSSWRCDGGPDCKDKSDEENC--AVATCRPDEFQCSDG-NCIHGSRQCDRE 258
F C +G CI +W+CDG PDC DKSDE+ C A + C P F C+ G +CI G +C+
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGF 94
Query: 259 YDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
DC D SDE C L ++ C +G CI +C+ +C+D SDE
Sbjct: 95 EDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/118 (39%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 238 PDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSG-ECITLDKVC 296
P F CS+G CI G+ QCD DC D SDE C GP F C SG CI C
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
Query: 297 NMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED 354
N DC D SDE + C N L + H N L I +C DG Q C+D
Sbjct: 92 NGFEDCPDGSDE--ENCTANPLLCSTAR-YHCKNGLCIDKSFIC-DG-----QNNCQD 140
Score = 41.6 bits (96), Expect = 0.003
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS 65
C + C++G CI ++CDG CQD SDE E+C S
Sbjct: 113 CSTARYHCKNGLCIDKSFICDGQNNCQDNSDE--ESCES 149
Score = 36.6 bits (83), Expect = 0.10
Identities = 28/113 (24%), Positives = 38/113 (33%), Gaps = 16/113 (14%)
Query: 276 CEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIG 335
C P F C +G CI C+ DC D SDE EC C G
Sbjct: 29 CNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASG 81
Query: 336 YECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVN--LEGGYKCQCEEGFQLD 386
C ++ + RC ++C D N L + C+ G +D
Sbjct: 82 IHC-------IIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCID 127
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 98.6 bits (244), Expect = 2e-20
Identities = 95/395 (24%), Positives = 148/395 (37%), Gaps = 78/395 (19%)
Query: 28 ERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFW 87
E F Q KC+ C G E+ E C +G F CI
Sbjct: 903 EGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAG-FMASEEGTNCI---- 957
Query: 88 RCDGQVDCDNGSDEQGCPPKTC--SQDEFRCH---DGKCISRQFVCDSDRDCLDGSDEAS 142
D D C C + FRC G ++++ C+ +CL+ S +
Sbjct: 958 ------DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS---T 1008
Query: 143 CPVLTC--GPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAF 200
CP C P S+QC +P C +G W +C D C
Sbjct: 1009 CPDEQCVNSPGSYQC-----VP----------CTEGFRGWNGQCL-------DVDECLEP 1046
Query: 201 EFHCLSGEC--IHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN-CIHGSRQ--- 254
C +G+C + S+ C D ++C D +C GN C++G +
Sbjct: 1047 NV-CANGDCSNLEGSYMCSCHKGYTRTPDHKHCR------DIDECQQGNLCVNGQCKNTE 1099
Query: 255 ------CDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDK----VCNMARDCRD 304
C + Y D+ C ++ C+ ++ C G+C + VC+
Sbjct: 1100 GSFRCTCGQGYQLSAAKDQ--CEDIDECQ--HRHLCAHGQCRNTEGSFQCVCDQGYRASG 1155
Query: 305 WSD--EPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPD 362
D E I EC ++ + G C + Y+C CPDGFQL + C+DI+EC+ P
Sbjct: 1156 LGDHCEDINECLEDKSVCQRGDCINTAGS----YDCTCPDGFQLDDNKTCQDINECEHPG 1211
Query: 363 TCSQL--CVNLEGGYKCQCEEGFQLDPHTKACKAV 395
C C+N EG + C C++GF + + C+ +
Sbjct: 1212 LCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDI 1246
Score = 77.8 bits (190), Expect = 4e-14
Identities = 102/395 (25%), Positives = 145/395 (36%), Gaps = 71/395 (17%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS-------VTCKSGDFSCGGR 78
RCE C G ++ + C+ EC + S E C++ V C G G+
Sbjct: 981 RCE----YCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 1036
Query: 79 ---VNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCL 135
V+ C+ +G DC N C +C + R D K C C+
Sbjct: 1037 CLDVDECLEPNVCANG--DCSNLEGSYMC---SCHKGYTRTPDHKHCRDIDECQQGNLCV 1091
Query: 136 DGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQR-------CR--- 185
+G + + SF+C TC CED DE R CR
Sbjct: 1092 NGQCKNT-------EGSFRC---TCGQGYQLSAAKDQCED-IDECQHRHLCAHGQCRNTE 1140
Query: 186 GLYVFQGDSS-PCSAFEFHCLS-GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQC 243
G + D S HC EC+ C G DC + + +C TC PD FQ
Sbjct: 1141 GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRG-DCINTAGSYDC---TC-PDGFQL 1195
Query: 244 SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCR 303
D +C+ C + C+N EG C G I+ D R C
Sbjct: 1196 DDNKTCQDINECEHPGLCGPQGE---CLNT---EGSFHCVCQQGFSISAD-----GRTCE 1244
Query: 304 DWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-P 361
D I EC N D++G C + + CLC GFQ + C D++EC+
Sbjct: 1245 D-----IDECVNNTVCDSHGFCDNTAGS----FRCLCYQGFQAPQDGQGCVDVNECELLS 1295
Query: 362 DTCSQ-LCVNLEGGYKCQC-EEGFQLDPHTKACKA 394
C + C N+EG + C C +E + P T C++
Sbjct: 1296 GVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1330
Score = 70.5 bits (171), Expect = 6e-12
Identities = 102/429 (23%), Positives = 146/429 (34%), Gaps = 71/429 (16%)
Query: 23 VGDRCERNE--FQCQDGK---CISYKWVCDGSAECQD------GSDESQETCLSVTCKSG 71
V +C+ E F+C G+ + K C+ ECQ G + E C G
Sbjct: 1091 VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQG 1150
Query: 72 DFSCG-----GRVNRCIPQFWRCDGQVDCDN--GSDEQGCPPKTCSQDEFRCHDGKCISR 124
+ G +N C+ C + DC N GS + CP D C D
Sbjct: 1151 YRASGLGDHCEDINECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEH 1209
Query: 125 QFVCDSDRDCLDGSDEASCPVLTCGPA-SFQCNSSTC-----IPQLWACDNDPDCEDGSD 178
+C +CL+ C C S + TC CD+ C++ +
Sbjct: 1210 PGLCGPQGECLNTEGSFHC---VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAG 1266
Query: 179 EWPQRCRGLYVFQGDSSPC-SAFEFHCLSGEC-------IHSSWRCDGGPDCKDKSDEEN 230
+ C + D C E LSG C + S+ C C D++ E +
Sbjct: 1267 SFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCV----CADENQEYS 1322
Query: 231 CAVATCRP---DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCE---------G 278
CR + ++C + + D V NVT E G
Sbjct: 1323 PMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG 1382
Query: 279 PNK--FKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN-----ECL------DNNGGC 325
N F C ++C + + + G N ECL NG C
Sbjct: 1383 DNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFC 1442
Query: 326 SHVCNDLKIGYECLCPDG-FQLVAQRRCEDIDECQDPDTCSQ-LCVNLEGGYKCQCEEGF 383
+ + GYEC C G + + +C D+DECQDP +C CVN EG Y C C
Sbjct: 1443 LNT----RPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPM 1498
Query: 384 QLDPHTKAC 392
LD K C
Sbjct: 1499 VLDASEKRC 1507
Score = 55.1 bits (131), Expect = 3e-07
Identities = 33/88 (37%), Positives = 43/88 (48%), Gaps = 4/88 (4%)
Query: 309 PIKECGTNECLDNNGGC-SHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDEC-QDPDTCS 365
P + NEC N C + C +L + Y C+C +G++ QR+C DIDEC Q CS
Sbjct: 869 PTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 928
Query: 366 Q-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
Q C N EG + C C GF C
Sbjct: 929 QGRCENTEGSFLCICPAGFMASEEGTNC 956
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/80 (37%), Positives = 41/80 (51%), Gaps = 13/80 (16%)
Query: 311 KECGT-NECLDNNGGCSHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDECQDPDTCSQLC 368
+ECG N C NG C V + GY C C DG+ L A+ C D++EC + + LC
Sbjct: 1624 EECGILNGC--ENGRCVRV----QEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC 1677
Query: 369 -----VNLEGGYKCQCEEGF 383
+N +G YKC C G+
Sbjct: 1678 KNAKCINTDGSYKCLCLPGY 1697
Score = 46.2 bits (108), Expect = 1e-04
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 340 CPDGFQLVAQRRCEDIDECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
C G++ V C+DI+ECQ C C+N G Y+C C+ GF DP +C
Sbjct: 612 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 332 LKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHT 389
+++ E Q++A + +I+EC +PD C C+NL Y C C EG++
Sbjct: 852 VEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQ 911
Query: 390 KAC 392
+ C
Sbjct: 912 RKC 914
Score = 30.8 bits (68), Expect = 5.6
Identities = 13/38 (34%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 356 DECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
+EC + C CV ++ GY C C +G+ LD C
Sbjct: 1624 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTC 1661
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 98.6 bits (244), Expect = 2e-20
Identities = 95/395 (24%), Positives = 148/395 (37%), Gaps = 78/395 (19%)
Query: 28 ERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFW 87
E F Q KC+ C G E+ E C +G F CI
Sbjct: 577 EGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAG-FMASEEGTNCI---- 631
Query: 88 RCDGQVDCDNGSDEQGCPPKTC--SQDEFRCH---DGKCISRQFVCDSDRDCLDGSDEAS 142
D D C C + FRC G ++++ C+ +CL+ S +
Sbjct: 632 ------DVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPS---T 682
Query: 143 CPVLTC--GPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAF 200
CP C P S+QC +P C +G W +C D C
Sbjct: 683 CPDEQCVNSPGSYQC-----VP----------CTEGFRGWNGQCL-------DVDECLEP 720
Query: 201 EFHCLSGEC--IHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN-CIHGSRQ--- 254
C +G+C + S+ C D ++C D +C GN C++G +
Sbjct: 721 NV-CANGDCSNLEGSYMCSCHKGYTRTPDHKHCR------DIDECQQGNLCVNGQCKNTE 773
Query: 255 ------CDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDK----VCNMARDCRD 304
C + Y D+ C ++ C+ ++ C G+C + VC+
Sbjct: 774 GSFRCTCGQGYQLSAAKDQ--CEDIDECQ--HRHLCAHGQCRNTEGSFQCVCDQGYRASG 829
Query: 305 WSD--EPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPD 362
D E I EC ++ + G C + Y+C CPDGFQL + C+DI+EC+ P
Sbjct: 830 LGDHCEDINECLEDKSVCQRGDCINTAGS----YDCTCPDGFQLDDNKTCQDINECEHPG 885
Query: 363 TCSQL--CVNLEGGYKCQCEEGFQLDPHTKACKAV 395
C C+N EG + C C++GF + + C+ +
Sbjct: 886 LCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDI 920
Score = 77.8 bits (190), Expect = 4e-14
Identities = 102/395 (25%), Positives = 145/395 (36%), Gaps = 71/395 (17%)
Query: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLS-------VTCKSGDFSCGGR 78
RCE C G ++ + C+ EC + S E C++ V C G G+
Sbjct: 655 RCE----YCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQ 710
Query: 79 ---VNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCL 135
V+ C+ +G DC N C +C + R D K C C+
Sbjct: 711 CLDVDECLEPNVCANG--DCSNLEGSYMC---SCHKGYTRTPDHKHCRDIDECQQGNLCV 765
Query: 136 DGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQR-------CR--- 185
+G + + SF+C TC CED DE R CR
Sbjct: 766 NGQCKNT-------EGSFRC---TCGQGYQLSAAKDQCED-IDECQHRHLCAHGQCRNTE 814
Query: 186 GLYVFQGDSS-PCSAFEFHCLS-GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQC 243
G + D S HC EC+ C G DC + + +C TC PD FQ
Sbjct: 815 GSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRG-DCINTAGSYDC---TC-PDGFQL 869
Query: 244 SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCR 303
D +C+ C + C+N EG C G I+ D R C
Sbjct: 870 DDNKTCQDINECEHPGLCGPQGE---CLNT---EGSFHCVCQQGFSISAD-----GRTCE 918
Query: 304 DWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRR-CEDIDECQD-P 361
D I EC N D++G C + + CLC GFQ + C D++EC+
Sbjct: 919 D-----IDECVNNTVCDSHGFCDNTAGS----FRCLCYQGFQAPQDGQGCVDVNECELLS 969
Query: 362 DTCSQ-LCVNLEGGYKCQC-EEGFQLDPHTKACKA 394
C + C N+EG + C C +E + P T C++
Sbjct: 970 GVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004
Score = 70.5 bits (171), Expect = 6e-12
Identities = 102/429 (23%), Positives = 146/429 (34%), Gaps = 71/429 (16%)
Query: 23 VGDRCERNE--FQCQDGK---CISYKWVCDGSAECQD------GSDESQETCLSVTCKSG 71
V +C+ E F+C G+ + K C+ ECQ G + E C G
Sbjct: 765 VNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQG 824
Query: 72 DFSCG-----GRVNRCIPQFWRCDGQVDCDN--GSDEQGCPPKTCSQDEFRCHDGKCISR 124
+ G +N C+ C + DC N GS + CP D C D
Sbjct: 825 YRASGLGDHCEDINECLEDKSVCQ-RGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEH 883
Query: 125 QFVCDSDRDCLDGSDEASCPVLTCGPA-SFQCNSSTC-----IPQLWACDNDPDCEDGSD 178
+C +CL+ C C S + TC CD+ C++ +
Sbjct: 884 PGLCGPQGECLNTEGSFHC---VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAG 940
Query: 179 EWPQRCRGLYVFQGDSSPC-SAFEFHCLSGEC-------IHSSWRCDGGPDCKDKSDEEN 230
+ C + D C E LSG C + S+ C C D++ E +
Sbjct: 941 SFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGEAFCENVEGSFLCV----CADENQEYS 996
Query: 231 CAVATCRP---DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCE---------G 278
CR + ++C + + D V NVT E G
Sbjct: 997 PMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWG 1056
Query: 279 PNK--FKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN-----ECL------DNNGGC 325
N F C ++C + + + G N ECL NG C
Sbjct: 1057 DNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFC 1116
Query: 326 SHVCNDLKIGYECLCPDG-FQLVAQRRCEDIDECQDPDTCSQ-LCVNLEGGYKCQCEEGF 383
+ + GYEC C G + + +C D+DECQDP +C CVN EG Y C C
Sbjct: 1117 LNT----RPGYECYCKQGTYYDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPM 1172
Query: 384 QLDPHTKAC 392
LD K C
Sbjct: 1173 VLDASEKRC 1181
Score = 55.1 bits (131), Expect = 3e-07
Identities = 33/88 (37%), Positives = 43/88 (48%), Gaps = 4/88 (4%)
Query: 309 PIKECGTNECLDNNGGC-SHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDEC-QDPDTCS 365
P + NEC N C + C +L + Y C+C +G++ QR+C DIDEC Q CS
Sbjct: 543 PTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCS 602
Query: 366 Q-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
Q C N EG + C C GF C
Sbjct: 603 QGRCENTEGSFLCICPAGFMASEEGTNC 630
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/80 (37%), Positives = 41/80 (51%), Gaps = 13/80 (16%)
Query: 311 KECGT-NECLDNNGGCSHVCNDLKIGYECLCPDGFQL-VAQRRCEDIDECQDPDTCSQLC 368
+ECG N C NG C V + GY C C DG+ L A+ C D++EC + + LC
Sbjct: 1298 EECGILNGC--ENGRCVRV----QEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLC 1351
Query: 369 -----VNLEGGYKCQCEEGF 383
+N +G YKC C G+
Sbjct: 1352 KNAKCINTDGSYKCLCLPGY 1371
Score = 46.2 bits (108), Expect = 1e-04
Identities = 21/54 (38%), Positives = 29/54 (53%), Gaps = 1/54 (1%)
Query: 340 CPDGFQLVAQRRCEDIDECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
C G++ V C+DI+ECQ C C+N G Y+C C+ GF DP +C
Sbjct: 286 CLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339
Score = 36.6 bits (83), Expect = 0.10
Identities = 18/63 (28%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 332 LKIGYECLCPDGFQLVAQRRCEDIDECQ-DPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHT 389
+++ E Q++A + +I+EC +PD C C+NL Y C C EG++
Sbjct: 526 VEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQ 585
Query: 390 KAC 392
+ C
Sbjct: 586 RKC 588
Score = 30.8 bits (68), Expect = 5.6
Identities = 13/38 (34%), Positives = 19/38 (50%), Gaps = 1/38 (2%)
Query: 356 DECQDPDTCSQ-LCVNLEGGYKCQCEEGFQLDPHTKAC 392
+EC + C CV ++ GY C C +G+ LD C
Sbjct: 1298 EECGILNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTC 1335
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 94.7 bits (234), Expect = 3e-19
Identities = 46/116 (39%), Positives = 63/116 (54%), Gaps = 8/116 (6%)
Query: 68 CKSGDFSCGGRVNR--CIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGK--CIS 123
C S S GG + C + RCDG C +G DEQGCP C D++ C G C +
Sbjct: 375 CGSSSDSDGGSLGDQGCFSEPQRCDGWWHCASGRDEQGCP--ACPPDQYPCEGGSGLCYT 432
Query: 124 RQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
C++ + C DG+DE +C +C P +F C ++ CI + W CD DC+DGSDE
Sbjct: 433 PADRCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE 486
Score = 85.1 bits (209), Expect = 3e-16
Identities = 84/342 (24%), Positives = 125/342 (36%), Gaps = 85/342 (24%)
Query: 67 TCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC-------PPKTCSQDEFRCHDG 119
+C++ +F C +C+P W+C+ +C +GSDE C P C F C
Sbjct: 165 SCQADEFRCDN--GKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGA 222
Query: 120 K---CISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDP----- 171
+ C+ + CD +DC DGSDEA CP L CG S P L+ P
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLHC 282
Query: 172 ----DCED------------GSDEWPQRCRGL----------YVFQGDSSPCS------- 198
D +D G D++ Q GL ++ + P S
Sbjct: 283 TWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGR 342
Query: 199 -AFEFHC---LSGECIHSSWRCDG-----GPDCKDKSDEENCAVATCRPDEFQCSDGNCI 249
+H +G +++++ G C SD + ++ D C
Sbjct: 343 LTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSL----------GDQGCF 392
Query: 250 HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCH--SGECITLDKVCNMARDCRDWSD 307
++CD + C DE GC C P+++ C SG C T CN + C D +D
Sbjct: 393 SEPQRCDGWWHCASGRDEQGC---PACP-PDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
Query: 308 EP--------IKECGTNECLDNNGGC--SHVCNDLKIGYECL 339
E CGTN C+ C C D + CL
Sbjct: 449 EKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCL 490
Score = 82.8 bits (203), Expect = 1e-15
Identities = 39/91 (42%), Positives = 50/91 (54%), Gaps = 6/91 (6%)
Query: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVT-----CKSGDFSCGG-RVN 80
C+ +EF+C +GKC+ W C+ EC DGSDE + + C G F C G R
Sbjct: 166 CQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARST 225
Query: 81 RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQ 111
RC+P RCDG DC +GSDE GCP C +
Sbjct: 226 RCLPVERRCDGLQDCGDGSDEAGCPDLACGR 256
Score = 80.5 bits (197), Expect = 6e-15
Identities = 51/158 (32%), Positives = 59/158 (37%), Gaps = 32/158 (20%)
Query: 82 CIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEA 141
C+P C D D GS D C S CD C G DE
Sbjct: 368 CLPWEQPCGSSSDSDGGS----------------LGDQGCFSEPQRCDGWWHCASGRDEQ 411
Query: 142 SCPVLTCGPASFQCN--SSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSA 199
CP C P + C S C C+N C DG+DE + C C
Sbjct: 412 GCPA--CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS----------CQP 457
Query: 200 FEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCR 237
FHC + CI +WRCDG DC+D SDE C A R
Sbjct: 458 GTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPR 495
Score = 69.7 bits (169), Expect = 1e-11
Identities = 34/80 (42%), Positives = 45/80 (56%), Gaps = 8/80 (10%)
Query: 27 CERNEFQCQDGKCISYKWV--CDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP 84
C +++ C+ G + Y C+ C DG+DE + C S C+ G F CG N CI
Sbjct: 416 CPPDQYPCEGGSGLCYTPADRCNNQKSCPDGADE--KNCFS--CQPGTFHCG--TNLCIF 469
Query: 85 QFWRCDGQVDCDNGSDEQGC 104
+ WRCDGQ DC +GSDE GC
Sbjct: 470 ETWRCDGQEDCQDGSDEHGC 489
Score = 69.3 bits (168), Expect = 1e-11
Identities = 38/108 (35%), Positives = 46/108 (42%), Gaps = 6/108 (5%)
Query: 36 DGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDC 95
D C S CDG C G DE + C C + C G C RC+ Q C
Sbjct: 388 DQGCFSEPQRCDGWWHCASGRDE--QGC--PACPPDQYPCEGGSGLCYTPADRCNNQKSC 443
Query: 96 DNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
+G+DE+ C +C F C CI + CD DC DGSDE C
Sbjct: 444 PDGADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Score = 58.2 bits (139), Expect = 3e-08
Identities = 34/93 (36%), Positives = 48/93 (51%), Gaps = 13/93 (13%)
Query: 234 ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV------TLCEGPNKFKC--- 284
A+C+ DEF+C +G C+ G QC+ +C D SDE C +LC G F C
Sbjct: 164 ASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPG-GTFPCSGA 222
Query: 285 HSGECITLDKVCNMARDCRDWSDE---PIKECG 314
S C+ +++ C+ +DC D SDE P CG
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCPDLACG 255
Score = 34.7 bits (78), Expect = 0.39
Identities = 24/91 (26%), Positives = 37/91 (40%), Gaps = 27/91 (29%)
Query: 280 NKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECL 339
++F+C +G+C+ CN +C D SDE G CS ++ L
Sbjct: 169 DEFRCDNGKCLPGPWQCNTVDECGDGSDE--------------GNCSAPASEPP---GSL 211
Query: 340 CPDGFQ----------LVAQRRCEDIDECQD 360
CP G L +RRC+ + +C D
Sbjct: 212 CPGGTFPCSGARSTRCLPVERRCDGLQDCGD 242
Score = 32.7 bits (73), Expect = 1.5
Identities = 18/55 (32%), Positives = 24/55 (43%), Gaps = 5/55 (9%)
Query: 17 AAAGTAVGDRCERNEFQCQDGK---CISYKWVCDGSAECQDGSDESQETCLSVTC 68
A A G C F C + C+ + CDG +C DGSDE+ C + C
Sbjct: 202 APASEPPGSLCPGGTFPCSGARSTRCLPVERRCDGLQDCGDGSDEA--GCPDLAC 254
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.449
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,013,322
Number of Sequences: 37866
Number of extensions: 1958758
Number of successful extensions: 9391
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 153
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 4093
Number of HSP's gapped (non-prelim): 2341
length of query: 860
length of database: 18,247,518
effective HSP length: 111
effective length of query: 749
effective length of database: 14,044,392
effective search space: 10519249608
effective search space used: 10519249608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.