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Search of human proteins with 4503687
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
(822 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens] 1642 0.0
gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens] 1390 0.0
gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens] 1349 0.0
gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens] 1097 0.0
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 800 0.0
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 260 3e-69
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 260 3e-69
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 254 3e-67
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 254 3e-67
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 254 3e-67
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 254 3e-67
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 254 3e-67
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 241 3e-63
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 241 3e-63
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 241 3e-63
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 241 3e-63
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 236 5e-62
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 236 6e-62
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 236 6e-62
gi|4503787 fyn-related kinase [Homo sapiens] 234 2e-61
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 234 2e-61
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 234 3e-61
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 233 7e-61
gi|148596974 TXK tyrosine kinase [Homo sapiens] 232 9e-61
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 230 4e-60
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 228 1e-59
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 228 1e-59
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 228 2e-59
gi|187475373 c-src tyrosine kinase [Homo sapiens] 224 3e-58
gi|4758078 c-src tyrosine kinase [Homo sapiens] 224 3e-58
>gi|4503687 feline sarcoma oncogene isoform 1 [Homo sapiens]
Length = 822
Score = 1642 bits (4251), Expect = 0.0
Identities = 822/822 (100%), Positives = 822/822 (100%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR
Sbjct: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
Query: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF
Sbjct: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
Query: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
Query: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
Query: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
Query: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
Query: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
Query: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
>gi|219842230 feline sarcoma oncogene isoform 2 [Homo sapiens]
Length = 764
Score = 1390 bits (3597), Expect = 0.0
Identities = 693/696 (99%), Positives = 696/696 (100%)
Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
+++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69 ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128
Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188
Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248
Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308
Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI
Sbjct: 309 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 368
Query: 427 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 486
LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ
Sbjct: 369 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 428
Query: 487 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546
GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 429 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 488
Query: 547 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 606
RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 489 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 548
Query: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 666
EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 549 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 608
Query: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 726
AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 609 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 668
Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 786
TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 669 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 728
Query: 787 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 729 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 764
>gi|219842233 feline sarcoma oncogene isoform 3 [Homo sapiens]
Length = 752
Score = 1349 bits (3491), Expect = 0.0
Identities = 706/822 (85%), Positives = 716/822 (87%), Gaps = 70/822 (8%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS
Sbjct: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW
Sbjct: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF
Sbjct: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLF 180
Query: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE
Sbjct: 181 AHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDE 240
Query: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE
Sbjct: 241 VVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNE 300
Query: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL
Sbjct: 301 LTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVL 360
Query: 361 QEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGR 420
QEALQGLQVALCSQAK LQ + E LLQ E
Sbjct: 361 QEALQGLQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------- 395
Query: 421 TPTLEILKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDF 480
PPP+ L+ + + HS
Sbjct: 396 ---------------------PPPVLLLQDDR-----------------------HSTSS 411
Query: 481 LVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 540
+E +G + L +L + F NLYRLEGEGFPSIPLLIDHLLSTQQPLTKK
Sbjct: 412 SEQEREGGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKK 470
Query: 541 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 600
SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL
Sbjct: 471 SGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDL 530
Query: 601 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 660
KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL
Sbjct: 531 KAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTL 590
Query: 661 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 720
LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR
Sbjct: 591 LQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR 650
Query: 721 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 780
QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP
Sbjct: 651 QVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLP 710
Query: 781 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 711 CPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 752
>gi|219842236 feline sarcoma oncogene isoform 4 [Homo sapiens]
Length = 694
Score = 1097 bits (2837), Expect = 0.0
Identities = 577/696 (82%), Positives = 590/696 (84%), Gaps = 70/696 (10%)
Query: 127 LTKTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 186
+++THSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY
Sbjct: 69 ISQTHSQDIEKLKSQYRALARDSAQAKRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRY 128
Query: 187 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 246
VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR
Sbjct: 129 VLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQDEVVAIHR 188
Query: 247 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 306
EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV
Sbjct: 189 EMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLNELTVESV 248
Query: 307 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 366
QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG
Sbjct: 249 QHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPRERVQLLGKRQVLQEALQG 308
Query: 367 LQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRTPTLEI 426
LQVALCSQAK LQ + E LLQ E
Sbjct: 309 LQVALCSQAK-------LQAQQE-----------LLQTKLEHLGPGE------------- 337
Query: 427 LKSHISGIFRPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGDFLVRESQ 486
PPP+ L+ + + HS +E +
Sbjct: 338 ---------------PPPVLLLQDDR-----------------------HSTSSSEQERE 359
Query: 487 GKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 546
G + L +L + F NLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH
Sbjct: 360 GGRTPTLEILKSHISGIFR-PKFSNLYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLH 418
Query: 547 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 606
RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ
Sbjct: 419 RAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQ 478
Query: 607 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 666
EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD
Sbjct: 479 EARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGD 538
Query: 667 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 726
AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW
Sbjct: 539 AAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKW 598
Query: 727 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 786
TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP
Sbjct: 599 TAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCP 658
Query: 787 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR
Sbjct: 659 DAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 694
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 800 bits (2066), Expect = 0.0
Identities = 420/827 (50%), Positives = 574/827 (69%), Gaps = 14/827 (1%)
Query: 1 MGFSSELCSPQGHGVLQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQS 60
MGF S+L H + ++Q+ ELRLLE ++K+MA R+KSD+EYA L ++ Q +
Sbjct: 1 MGFGSDL--KNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKEST 58
Query: 61 RAISPDSPISQSWAEITSQTEGLSRLLRQHAEDLNSGPLSKLSLLIRERQQLRKTYSEQW 120
++ S +S+SW + QTE LSR+++ HAEDLNSGPL +L+++I+++QQ++K+Y
Sbjct: 59 VQMNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVH 118
Query: 121 QQLQQELTKTHSQDIEKLKSQYRALARDSAQAKRKYQEA-SKDKDRDKAKDKYVRSLWKL 179
QQ++ E+ K ++EKLK YR L ++ AK KY+EA +K K+ +KAK++Y ++ KL
Sbjct: 119 QQIEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKL 178
Query: 180 FAHHNRYVLGVRAAQLHHQHHHQLLLPGLLRSLQDLHEEMACILKEILQEYLEISSLVQD 239
HN+YVL ++ AQLH ++ + LP LL SLQ + EEM LK I EY +I+SLV +
Sbjct: 179 HMLHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTE 238
Query: 240 EVVAIHREMAAAAARIQPEAEYQGFLRQYGSAPDVPPCVTFDESLLEEGEPLEPGELQLN 299
E+V +H+E+ + +I P EY F+ + + + FD SLLEE E L+ E+ N
Sbjct: 239 EIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWN 298
Query: 300 ELTVESVQHTLTSVTDELAVATEMVFRRQEMVTQLQQELRNEEENTHPR-ERVQLLGKRQ 358
LT ES+Q L ++ +EL +M+ ++E V +L++ + E + + V LL ++Q
Sbjct: 299 NLTAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQ 358
Query: 359 VLQEALQGLQVALCSQAKLQAQQELLQTKLEHLGPGEPPPVLLLQDDRHSTSSSEQEREG 418
L+E Q +Q C++AK AQ+ELL+ K++ EPPPV+ ++D S +S E++
Sbjct: 359 ALEELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKE-- 416
Query: 419 GRTPTLEILKSHISGIFR-PKFSLPPPL--QLIPEVQKPLHEQLWYHGAIPRAEVAELLV 475
R E ++ I+GI R PK +L +I +KPL EQ WYHGAIPR E ELL
Sbjct: 417 -RLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLK 475
Query: 476 HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFPSIPLLIDHLLSTQ 534
GDFLVRES GK EYVLSV DG RHFIIQ +DN+YR EG GF +IP LIDH +T+
Sbjct: 476 KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTK 535
Query: 535 QPLTKKSGVVLHRAVPKDK-WVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCR 593
Q +TKKSGVVL +PKDK W+L+HED++LGE +G+GNFGEV+ G L+ D T VAVK+C+
Sbjct: 536 QVITKKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLK-DKTSVAVKTCK 594
Query: 594 ETLPPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGA 653
E LP +LK KFLQEA+ILKQY HPNIV+LIGVCTQ+QP+YI+MELV GGDFLTFLR +
Sbjct: 595 EDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKD 654
Query: 654 RLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVY 713
L++K L++ DAAAGM YLESK CIHRDLAARNCLV E NVLKISDFGMSR+E GVY
Sbjct: 655 ELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVY 714
Query: 714 AASGGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFV 773
++S GL+Q+P+KWTAPEALNYGRYSSESDVWSFGILLWETFSLG PYP ++NQQ RE V
Sbjct: 715 SSS-GLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQV 773
Query: 774 EKGGRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKR 820
E+G R+ P+ CP+ + ++M +CW Y+P RP FS + +EL I+++
Sbjct: 774 ERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRK 820
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 260 bits (665), Expect = 3e-69
Identities = 144/380 (37%), Positives = 221/380 (58%), Gaps = 22/380 (5%)
Query: 455 LHEQLWYHGAIPRAEVAELLVHSG---DFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLD 510
L + WYHG + R AE L+ SG FLVRES+ + +S+ ++G H+ I +
Sbjct: 122 LEKHSWYHGPVSR-NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 511 N--LYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHRAVPK-DKWVLNHE 559
+ LY F ++ L+ H + + P K++ ++ P DKW +
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 240
Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPN 618
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+ HPN
Sbjct: 241 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPN 297
Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
+V+L+GVCT++ P YI+ E + G+ L +LR + LL M ++ MEYLE K
Sbjct: 298 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
IHRDLAARNCLV E +++K++DFG+SR Y A G + P+KWTAPE+L Y ++
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKF 416
Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
S +SDVW+FG+LLWE + G SPYP + Q E +EK R+ PE CP+ V+ LM CW
Sbjct: 417 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 476
Query: 798 AYEPGQRPSFSTIYQELQSI 817
+ P RPSF+ I+Q +++
Sbjct: 477 QWNPSDRPSFAEIHQAFETM 496
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 260 bits (665), Expect = 3e-69
Identities = 144/380 (37%), Positives = 221/380 (58%), Gaps = 22/380 (5%)
Query: 455 LHEQLWYHGAIPRAEVAELLVHSG---DFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLD 510
L + WYHG + R AE L+ SG FLVRES+ + +S+ ++G H+ I +
Sbjct: 141 LEKHSWYHGPVSR-NAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 511 N--LYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVVLHRAVPK-DKWVLNHE 559
+ LY F ++ L+ H + + P K++ ++ P DKW +
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT 259
Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPN 618
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+ HPN
Sbjct: 260 DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIKHPN 316
Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
+V+L+GVCT++ P YI+ E + G+ L +LR + LL M ++ MEYLE K
Sbjct: 317 LVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 376
Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
IHRDLAARNCLV E +++K++DFG+SR Y A G + P+KWTAPE+L Y ++
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKF 435
Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
S +SDVW+FG+LLWE + G SPYP + Q E +EK R+ PE CP+ V+ LM CW
Sbjct: 436 SIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW 495
Query: 798 AYEPGQRPSFSTIYQELQSI 817
+ P RPSF+ I+Q +++
Sbjct: 496 QWNPSDRPSFAEIHQAFETM 515
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 254 bits (648), Expect = 3e-67
Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)
Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
L + WYHG + R+ LL + +G FLVRES+ + +S+ ++G H+ I + +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
+Y F ++ L+ H + L LH PK DKW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 268
Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 325
Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++ MEYL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
E K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAPE+L Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 444
Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
+S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V+ LM
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
CW + P RPSF+ +Q +++
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 254 bits (648), Expect = 3e-67
Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)
Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
L + WYHG + R+ LL + +G FLVRES+ + +S+ ++G H+ I + +
Sbjct: 168 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 227
Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
+Y F ++ L+ H + L LH PK DKW +
Sbjct: 228 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 283
Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+
Sbjct: 284 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 340
Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++ MEYL
Sbjct: 341 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 400
Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
E K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAPE+L Y
Sbjct: 401 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 459
Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
+S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V+ LM
Sbjct: 460 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519
Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
CW + P RPSF+ +Q +++
Sbjct: 520 ACWKWSPADRPSFAETHQAFETM 542
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 254 bits (648), Expect = 3e-67
Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)
Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
L + WYHG + R+ LL + +G FLVRES+ + +S+ ++G H+ I + +
Sbjct: 147 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 206
Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
+Y F ++ L+ H + L LH PK DKW +
Sbjct: 207 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 262
Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+
Sbjct: 263 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 319
Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++ MEYL
Sbjct: 320 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 379
Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
E K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAPE+L Y
Sbjct: 380 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 438
Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
+S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V+ LM
Sbjct: 439 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 498
Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
CW + P RPSF+ +Q +++
Sbjct: 499 ACWKWSPADRPSFAETHQAFETM 521
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 254 bits (648), Expect = 3e-67
Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)
Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
L + WYHG + R+ LL + +G FLVRES+ + +S+ ++G H+ I + +
Sbjct: 153 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 212
Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
+Y F ++ L+ H + L LH PK DKW +
Sbjct: 213 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 268
Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+
Sbjct: 269 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 325
Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++ MEYL
Sbjct: 326 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 385
Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
E K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAPE+L Y
Sbjct: 386 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 444
Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
+S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V+ LM
Sbjct: 445 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 504
Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
CW + P RPSF+ +Q +++
Sbjct: 505 ACWKWSPADRPSFAETHQAFETM 527
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 254 bits (648), Expect = 3e-67
Identities = 144/383 (37%), Positives = 215/383 (56%), Gaps = 28/383 (7%)
Query: 455 LHEQLWYHGAIPRAEVAELL--VHSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDN 511
L + WYHG + R+ LL + +G FLVRES+ + +S+ ++G H+ I + +
Sbjct: 132 LEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTAD 191
Query: 512 --LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVPK-------------DKWVL 556
+Y F ++ L+ H + L LH PK DKW +
Sbjct: 192 GKVYVTAESRFSTLAELVHHHSTVADGLV----TTLHYPAPKCNKPTVYGVSPIHDKWEM 247
Query: 557 NHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYS 615
D+ + ++G G +GEV+ G + + VAVK+ +E T+ + +FL+EA ++K+
Sbjct: 248 ERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVE---EFLKEAAVMKEIK 304
Query: 616 HPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYL 674
HPN+V+L+GVCT + P YIV E + G+ L +LR + LL M ++ MEYL
Sbjct: 305 HPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYL 364
Query: 675 ESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNY 734
E K IHRDLAARNCLV E +V+K++DFG+SR Y A G + P+KWTAPE+L Y
Sbjct: 365 EKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAY 423
Query: 735 GRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLME 794
+S +SDVW+FG+LLWE + G SPYP + Q + +EKG R+ PE CP V+ LM
Sbjct: 424 NTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 483
Query: 795 QCWAYEPGQRPSFSTIYQELQSI 817
CW + P RPSF+ +Q +++
Sbjct: 484 ACWKWSPADRPSFAETHQAFETM 506
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 241 bits (614), Expect = 3e-63
Identities = 147/399 (36%), Positives = 216/399 (54%), Gaps = 29/399 (7%)
Query: 443 PPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLSVLWDG 499
P L+ + L WY+ +I R + +LL+ +G F+VR+S+ Y +SV
Sbjct: 222 PSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKA 281
Query: 500 LP-------RHFIIQSLDN----LYRLEGEGFPSIPLLIDH--------LLSTQQPLT-K 539
+ +H+ I+ ++ Y E F SIPLLI++ + + P+
Sbjct: 282 VVSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFG 341
Query: 540 KSGVVLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGR-LRADNTLVAVKSCRETLPP 598
+ + + KWV++ +L ++IG G FG V G L D VA+K+ RE
Sbjct: 342 RQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIREGAMS 399
Query: 599 DLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVK 658
+ F++EA ++ + SHP +V+L GVC ++ PI +V E ++ G +LRT+ +
Sbjct: 400 E--EDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAE 457
Query: 659 TLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGG 718
TLL M D GM YLE C IHRDLAARNCLV E V+K+SDFGM+R D Y +S G
Sbjct: 458 TLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTG 517
Query: 719 LRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGR 778
+ PVKW +PE ++ RYSS+SDVWSFG+L+WE FS G PY N SN + E + G R
Sbjct: 518 TK-FPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFR 576
Query: 779 LPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
L P L V+++M CW P RP+FS + ++L I
Sbjct: 577 LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 241 bits (614), Expect = 3e-63
Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)
Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
R S P L L+P W+HG I E + L G FLVRES + +YV
Sbjct: 67 REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 116
Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
L V + H+ + D + E F ++ +++H + +P K
Sbjct: 117 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 176
Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
+ + W+LN + L LG QIG G FG V G V C T
Sbjct: 177 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 231
Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
FL E ++ + H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ
Sbjct: 232 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 290
Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
A GMEYLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++
Sbjct: 291 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 345
Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ P
Sbjct: 346 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 405
Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
E CP V LM CW EP +RP F + ++L
Sbjct: 406 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 241 bits (614), Expect = 3e-63
Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)
Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
R S P L L+P W+HG I E + L G FLVRES + +YV
Sbjct: 109 REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 158
Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
L V + H+ + D + E F ++ +++H + +P K
Sbjct: 159 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 218
Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
+ + W+LN + L LG QIG G FG V G V C T
Sbjct: 219 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 273
Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
FL E ++ + H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ
Sbjct: 274 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 332
Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
A GMEYLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++
Sbjct: 333 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 387
Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ P
Sbjct: 388 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 447
Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
E CP V LM CW EP +RP F + ++L
Sbjct: 448 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 241 bits (614), Expect = 3e-63
Identities = 153/392 (39%), Positives = 208/392 (53%), Gaps = 34/392 (8%)
Query: 436 RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLV--HSGDFLVRES-QGKQEYV 492
R S P L L+P W+HG I E + L G FLVRES + +YV
Sbjct: 108 REALSADPKLSLMP----------WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYV 157
Query: 493 LSVLWDGLPRHFIIQSLDNLYRL-EGEGFPSIPLLIDHLLSTQ--------QPLTKKSGV 543
L V + H+ + D + E F ++ +++H + +P K
Sbjct: 158 LCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTK 217
Query: 544 VLHRAVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK 603
+ + W+LN + L LG QIG G FG V G V C T
Sbjct: 218 SAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQA----- 272
Query: 604 FLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEG-ARLRVKTLLQ 662
FL E ++ + H N+VRL+GV Q +YIVME V G+ + FLRT G A + LLQ
Sbjct: 273 FLDETAVMTKMQHENLVRLLGVILH-QGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQ 331
Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
A GMEYLESK +HRDLAARN LV+E V K+SDFG+++ E G+ ++ ++
Sbjct: 332 FSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS-----RL 386
Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
PVKWTAPEAL +G+++S+SDVWSFG+LLWE FS G +PYP +S ++ E VEKG R+ P
Sbjct: 387 PVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPP 446
Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQEL 814
E CP V LM CW EP +RP F + ++L
Sbjct: 447 EGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 478
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 236 bits (603), Expect = 5e-62
Identities = 157/444 (35%), Positives = 230/444 (51%), Gaps = 27/444 (6%)
Query: 396 PPPVLLLQDDRHSTSSSEQEREGGRTPTLE-----ILKSHISGIFRPKFSLPPPLQLIPE 450
P L L D R G R LE I +SG +P L P +
Sbjct: 53 PQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSG--QPSAGLVPITHVAKA 110
Query: 451 VQKPLHEQLWYHGAIPRAEVAELLV----HSGDFLVRESQGKQE-YVLSVLWDGLPRHFI 505
+ L +Q WY + R + +LL+ G FL+R S+ Y LSV H+
Sbjct: 111 SPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYR 170
Query: 506 IQSL--DNLYRLEGEGFPSIPLLIDHLLST----QQPLTKKSGVVLHRAVPKDKWVLNHE 559
+ +LY +G FP + L+ + + Q PL + + +A +D W H
Sbjct: 171 VSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPC--MPQKAPRQDVWERPHS 228
Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFL-QEARILKQYSHPN 618
+ LG ++G G FGEV+ G L + VA+K + ++K L +E + LK H
Sbjct: 229 EFALGRKLGEGYFGEVWEG-LWLGSLPVAIKVIKSA---NMKLTDLAKEIQTLKGLRHER 284
Query: 619 IVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESK 677
++RL VC+ +P+YIV EL++ G+ FL T EG LR+ LL A GM YLE +
Sbjct: 285 LIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQ 344
Query: 678 CCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRY 737
+HRDLAARN LV + K++DFG++R D +Y+ S + +PVKWTAPEA NY +
Sbjct: 345 RVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSK-IPVKWTAPEAANYRVF 403
Query: 738 SSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCW 797
S +SDVWSFG+LL E F+ G PY ++N +T + + +G RLP P CP V+ LM +CW
Sbjct: 404 SQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECW 463
Query: 798 AYEPGQRPSFSTIYQELQSIRKRH 821
P +RPSF+T+ ++L +I + H
Sbjct: 464 RSSPEERPSFATLREKLHAIHRCH 487
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 236 bits (602), Expect = 6e-62
Identities = 147/406 (36%), Positives = 219/406 (53%), Gaps = 26/406 (6%)
Query: 438 KFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLS 494
K S P E ++ L + W+ G I R++ +LL G F+VR S Y +S
Sbjct: 274 KISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVS 333
Query: 495 VLWD------GLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLT 538
+ G +H+ + + + LY E F SIP LI + + + P++
Sbjct: 334 LFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 393
Query: 539 KKSGVVLHR-AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TL 596
K+ V ++ W L E++ L +++G G FG V G+ + VAVK +E ++
Sbjct: 394 TKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSM 452
Query: 597 PPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR 656
D +F QEA+ + + SHP +V+ GVC+++ PIYIV E + G L +LR+ G L
Sbjct: 453 SED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE 509
Query: 657 VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAAS 716
LL+M D GM +LES IHRDLAARNCLV +K+SDFGM+R D Y +S
Sbjct: 510 PSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS 569
Query: 717 GGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
G + PVKW+APE +Y +YSS+SDVW+FGIL+WE FSLG PY N Q V +G
Sbjct: 570 VGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQG 628
Query: 777 GRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
RL P L D ++++M CW P +RP+F + ++ +R++ +
Sbjct: 629 HRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDK 674
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 236 bits (602), Expect = 6e-62
Identities = 147/406 (36%), Positives = 219/406 (53%), Gaps = 26/406 (6%)
Query: 438 KFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLS 494
K S P E ++ L + W+ G I R++ +LL G F+VR S Y +S
Sbjct: 274 KISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVS 333
Query: 495 VLWD------GLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLT 538
+ G +H+ + + + LY E F SIP LI + + + P++
Sbjct: 334 LFSKAVNDKKGTVKHYHVHTNAENKLYLAENYCFDSIPKLIHYHQHNSAGMITRLRHPVS 393
Query: 539 KKSGVVLHR-AVPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TL 596
K+ V ++ W L E++ L +++G G FG V G+ + VAVK +E ++
Sbjct: 394 TKANKVPDSVSLGNGIWELKREEITLLKELGSGQFGVVQLGKWKGQYD-VAVKMIKEGSM 452
Query: 597 PPDLKAKFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLR 656
D +F QEA+ + + SHP +V+ GVC+++ PIYIV E + G L +LR+ G L
Sbjct: 453 SED---EFFQEAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISNGCLLNYLRSHGKGLE 509
Query: 657 VKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAAS 716
LL+M D GM +LES IHRDLAARNCLV +K+SDFGM+R D Y +S
Sbjct: 510 PSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDLCVKVSDFGMTRYVLDDQYVSS 569
Query: 717 GGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKG 776
G + PVKW+APE +Y +YSS+SDVW+FGIL+WE FSLG PY N Q V +G
Sbjct: 570 VGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSQVVLKVSQG 628
Query: 777 GRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSIRKRHR 822
RL P L D ++++M CW P +RP+F + ++ +R++ +
Sbjct: 629 HRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIEPLREKDK 674
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 234 bits (598), Expect = 2e-61
Identities = 139/385 (36%), Positives = 223/385 (57%), Gaps = 27/385 (7%)
Query: 453 KPLHEQLWYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVLWDGLPRHFIIQ 507
+ L + W+ GAI R++ + L++S G FL+RES+ K E+ LSVL + +H+ I+
Sbjct: 109 RSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIK 168
Query: 508 SLDN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGV-VLHRAVPK---------DKWV 555
LD + F ++ + H T L K G L VP D+W
Sbjct: 169 RLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWE 228
Query: 556 LNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQY 614
++ + L +++G G FGEV+ G L + T VAVK+ + ++ P+ FL+EA+I+K
Sbjct: 229 IDRNSIQLLKRLGSGQFGEVWEG-LWNNTTPVAVKTLKPGSMDPN---DFLREAQIMKNL 284
Query: 615 SHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEY 673
HP +++L VCT + PIYI+ EL++ G +L+ + G+++ + + M A+GM Y
Sbjct: 285 RHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAY 344
Query: 674 LESKCCIHRDLAARNCLVTEKNVLKISDFGMSRE---EADGVYAASGGLRQVPVKWTAPE 730
LES+ IHRDLAARN LV E N+ K++DFG++R + + +Y + ++ +PVKWTAPE
Sbjct: 345 LESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIK-LPVKWTAPE 403
Query: 731 ALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVF 790
A+ ++S +SDVWSFGILL+E + G PY ++ Q + + + RLP P CP +
Sbjct: 404 AIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFY 463
Query: 791 RLMEQCWAYEPGQRPSFSTIYQELQ 815
+M +CW EP +RP+F T+ +L+
Sbjct: 464 NIMLECWNAEPKERPTFETLRWKLE 488
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 234 bits (597), Expect = 2e-61
Identities = 145/379 (38%), Positives = 212/379 (55%), Gaps = 29/379 (7%)
Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
WY G + R + L+ G+ FL+RES+ K Y LS+ WD + +H+ I+ L
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP---------KDKWVLNH 558
DN Y F ++ L+ H L + V H+ +P KD W +
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPR 268
Query: 559 EDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHP 617
E L L +++G G FGEV+ G NT VA+K+ + T+ P+ FL+EA+I+K+ H
Sbjct: 269 ESLQLIKRLGNGQFGEVWMGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHD 324
Query: 618 NIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLES 676
+V+L V ++ +PIYIV E + G L FL+ EG L++ L+ M AAGM Y+E
Sbjct: 325 KLVQLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIER 383
Query: 677 KCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGR 736
IHRDL + N LV + KI+DFG++R D Y A G + P+KWTAPEA YGR
Sbjct: 384 MNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGR 442
Query: 737 YSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQC 796
++ +SDVWSFGILL E + G PYP ++N++ E VE+G R+PCP+ CP ++ LM C
Sbjct: 443 FTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHC 502
Query: 797 WAYEPGQRPSFSTIYQELQ 815
W +P +RP+F + L+
Sbjct: 503 WKKDPEERPTFEYLQSFLE 521
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 234 bits (596), Expect = 3e-61
Identities = 134/395 (33%), Positives = 220/395 (55%), Gaps = 26/395 (6%)
Query: 444 PLQLIPEVQKPLHEQLWYHGAIPRAEVAELLVHSGD---FLVRESQGKQEYVLSVLW--- 497
P + E + + WY + R++ +LL G F+VR+S +Y +SV
Sbjct: 265 PSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKST 324
Query: 498 ---DGLPRHFIIQSL--DNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKSGVV 544
G+ RH+++ S Y E F +IP LI++ + + P+++++
Sbjct: 325 GDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNA 384
Query: 545 LHRA-VPKDKWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKA 602
A + W ++ +DL +++G G FG V G+ R VA+K +E ++ D
Sbjct: 385 PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYD-VAIKMIKEGSMSED--- 440
Query: 603 KFLQEARILKQYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQ 662
+F++EA+++ SH +V+L GVCT+++PI+I+ E + G L +LR R + + LL+
Sbjct: 441 EFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLE 500
Query: 663 MVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQV 722
M D MEYLESK +HRDLAARNCLV ++ V+K+SDFG+SR D Y +S G +
Sbjct: 501 MCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVG-SKF 559
Query: 723 PVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCP 782
PV+W+ PE L Y ++SS+SD+W+FG+L+WE +SLG PY +N +T E + +G RL P
Sbjct: 560 PVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRP 619
Query: 783 ELCPDAVFRLMEQCWAYEPGQRPSFSTIYQELQSI 817
L + V+ +M CW + +RP+F + + +
Sbjct: 620 HLASEKVYTIMYSCWHEKADERPTFKILLSNILDV 654
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 233 bits (593), Expect = 7e-61
Identities = 142/385 (36%), Positives = 208/385 (54%), Gaps = 26/385 (6%)
Query: 455 LHEQLWYHGAIPRAEVAELLVHS---GDFLVRESQGKQEYVLSVLW----DGLP--RHFI 505
L + WY + R++ +LL G F+VR+S Y +S+ +G RH+
Sbjct: 242 LDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHYH 301
Query: 506 IQ----SLDNLYRLEGEGFPSIPLLIDH--------LLSTQQPLTKKS-GVVLHRAVPKD 552
I+ S Y E F SIP +I++ + + P++ K +
Sbjct: 302 IKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSYE 361
Query: 553 KWVLNHEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILK 612
KW +N +L ++G G FG V G+ RA VA+K+ RE + F++EA+++
Sbjct: 362 KWEINPSELTFMRELGSGLFGVVRLGKWRAQYK-VAIKAIREGAM--CEEDFIEEAKVMM 418
Query: 613 QYSHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGME 672
+ +HP +V+L GVCTQ++PIYIV E ++ G L FLR LL M D GME
Sbjct: 419 KLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGME 478
Query: 673 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEAL 732
YLE IHRDLAARNCLV+E V+K+SDFGM+R D Y +S G + PVKW PE
Sbjct: 479 YLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAK-FPVKWCPPEVF 537
Query: 733 NYGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRL 792
NY R+SS+SDVWSFG+L+WE F+ G P+ +N + V +G RL P+L + V+ +
Sbjct: 538 NYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEV 597
Query: 793 MEQCWAYEPGQRPSFSTIYQELQSI 817
M +CW +P RPSF + + + +
Sbjct: 598 MLRCWQEKPEGRPSFEDLLRTIDEL 622
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 232 bits (592), Expect = 9e-61
Identities = 138/378 (36%), Positives = 208/378 (55%), Gaps = 24/378 (6%)
Query: 460 WYHGAIPRAEVAELLVHS---GDFLVRESQGKQEYVLSVLW------DGLPRHFIIQSLD 510
WYH I R + LL G F+VR+S+ Y +SV + +H+ I+ D
Sbjct: 150 WYHRNITRNQAEHLLRQESKEGAFIVRDSRHLGSYTISVFMGARRSTEAAIKHYQIKKND 209
Query: 511 N--LYRLEGEGFPSIPLLI---DHLLSTQQPLTKKSGVVLHRAVPK------DKWVLNHE 559
+ Y E F SIP LI H + + ++ +P +KW ++
Sbjct: 210 SGQWYVAERHAFQSIPELIWYHQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPS 269
Query: 560 DLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNI 619
+L ++IG G FG V G R+ + VA+K+ E + F++EA+++ + SH +
Sbjct: 270 ELAFIKEIGSGQFGVVHLGEWRS-HIQVAIKAINEGSMSE--EDFIEEAKVMMKLSHSKL 326
Query: 620 VRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCC 679
V+L GVC Q++P+YIV E ++ G L +LR +LR + LL + D GMEYLE
Sbjct: 327 VQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDICEGMEYLERNGY 386
Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
IHRDLAARNCLV+ ++KISDFGM+R D Y +S G + P+KW+ PE + +YSS
Sbjct: 387 IHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAK-FPIKWSPPEVFLFNKYSS 445
Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
+SDVWSFG+L+WE F+ G P+ N SN Q E + +G RL P L P +++ +M CW
Sbjct: 446 KSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHE 505
Query: 800 EPGQRPSFSTIYQELQSI 817
+P RP+F+ + + + I
Sbjct: 506 KPEGRPTFAELLRAVTEI 523
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 230 bits (587), Expect = 4e-60
Identities = 148/376 (39%), Positives = 208/376 (55%), Gaps = 26/376 (6%)
Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
WY G + R + LL++ G+ FLVRES+ K Y LS+ WD + +H+ I+ L
Sbjct: 158 WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKL 217
Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP------KDKWVLNHEDL 561
DN Y F ++ L+ H L K V P KD W + E L
Sbjct: 218 DNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESL 277
Query: 562 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIV 620
L ++G+G FGEV+ G T VA+K+ + T+ P+ FLQEA+I+K+ H +V
Sbjct: 278 RLEVKLGQGCFGEVWMGTWNG-TTKVAIKTLKPGTMMPEA---FLQEAQIMKKLRHDKLV 333
Query: 621 RLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCC 679
L V ++ +PIYIV E + G L FL+ +G L++ L+ M A GM Y+E
Sbjct: 334 PLYAVVSE-EPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNY 392
Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
IHRDL A N LV E V KI+DFG++R D Y A G + P+KWTAPEA YGR++
Sbjct: 393 IHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTI 451
Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
+SDVWSFGIL E + G PYP + N++ E VE+G R+PCP+ CP+++ LM CW
Sbjct: 452 KSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKK 511
Query: 800 EPGQRPSFSTIYQELQ 815
+P +RP+F I L+
Sbjct: 512 DPDERPTFEYIQSFLE 527
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 228 bits (582), Expect = 1e-59
Identities = 150/380 (39%), Positives = 214/380 (56%), Gaps = 34/380 (8%)
Query: 460 WYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
WY G I R E LL+++ G FLVRES+ K Y LSV +D +H+ I+ L
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 510 DN--LYRLEGEGFPSIPLLID----------HLLSTQQPLTKKSGVVLHRAVPKDKWVLN 557
D+ Y F S+ L+ H L+T P +K + + KD W +
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT----QGLAKDAWEIP 266
Query: 558 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSH 616
E L L ++G+G FGEV+ G T VA+K+ + T+ P+ FLQEA+++K+ H
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRH 322
Query: 617 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEYLE 675
+V+L V ++ +PIYIV E + G L FL+ E G LR+ L+ M A+GM Y+E
Sbjct: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
Query: 676 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 735
+HRDL A N LV E V K++DFG++R D Y A G + P+KWTAPEA YG
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYG 440
Query: 736 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 795
R++ +SDVWSFGILL E + G PYP + N++ + VE+G R+PCP CP+++ LM Q
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
Query: 796 CWAYEPGQRPSFSTIYQELQ 815
CW EP +RP+F + L+
Sbjct: 501 CWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 228 bits (582), Expect = 1e-59
Identities = 150/380 (39%), Positives = 214/380 (56%), Gaps = 34/380 (8%)
Query: 460 WYHGAIPRAEVAELLVHS----GDFLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
WY G I R E LL+++ G FLVRES+ K Y LSV +D +H+ I+ L
Sbjct: 151 WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKL 210
Query: 510 DN--LYRLEGEGFPSIPLLID----------HLLSTQQPLTKKSGVVLHRAVPKDKWVLN 557
D+ Y F S+ L+ H L+T P +K + + KD W +
Sbjct: 211 DSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQT----QGLAKDAWEIP 266
Query: 558 HEDLVLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSH 616
E L L ++G+G FGEV+ G T VA+K+ + T+ P+ FLQEA+++K+ H
Sbjct: 267 RESLRLEVKLGQGCFGEVWMGTWNG-TTRVAIKTLKPGTMSPEA---FLQEAQVMKKLRH 322
Query: 617 PNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTE-GARLRVKTLLQMVGDAAAGMEYLE 675
+V+L V ++ +PIYIV E + G L FL+ E G LR+ L+ M A+GM Y+E
Sbjct: 323 EKLVQLYAVVSE-EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVE 381
Query: 676 SKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYG 735
+HRDL A N LV E V K++DFG++R D Y A G + P+KWTAPEA YG
Sbjct: 382 RMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYG 440
Query: 736 RYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQ 795
R++ +SDVWSFGILL E + G PYP + N++ + VE+G R+PCP CP+++ LM Q
Sbjct: 441 RFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQ 500
Query: 796 CWAYEPGQRPSFSTIYQELQ 815
CW EP +RP+F + L+
Sbjct: 501 CWRKEPEERPTFEYLQAFLE 520
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 228 bits (581), Expect = 2e-59
Identities = 142/376 (37%), Positives = 208/376 (55%), Gaps = 26/376 (6%)
Query: 460 WYHGAIPRAEVAELLVHSGD----FLVRESQG-KQEYVLSVL-WDGLP----RHFIIQSL 509
WY G + R + L+ G+ FL+RES+ K Y LS+ WD + +H+ I+ L
Sbjct: 149 WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKL 208
Query: 510 DN--LYRLEGEGFPSIPLLIDHLLSTQQPLTKKSGVVLHRAVP------KDKWVLNHEDL 561
DN Y F ++ L+ H L V+ P KD W + L
Sbjct: 209 DNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSGLAKDAWEVARRSL 268
Query: 562 VLGEQIGRGNFGEVFSGRLRADNTLVAVKSCRE-TLPPDLKAKFLQEARILKQYSHPNIV 620
L +++G+G F EV+ G NT VA+K+ + T+ P+ FL+EA+I+K+ H +V
Sbjct: 269 CLEKKLGQGCFAEVWLGTWNG-NTKVAIKTLKPGTMSPE---SFLEEAQIMKKLKHDKLV 324
Query: 621 RLIGVCTQKQPIYIVMELVQGGDFLTFLRT-EGARLRVKTLLQMVGDAAAGMEYLESKCC 679
+L V ++ +PIYIV E + G L FL+ EG L++ L+ M AAGM Y+E
Sbjct: 325 QLYAVVSE-EPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNY 383
Query: 680 IHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSS 739
IHRDL + N LV + KI+DFG++R D Y A G + P+KWTAPEA YGR++
Sbjct: 384 IHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK-FPIKWTAPEAALYGRFTI 442
Query: 740 ESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAY 799
+SDVWSFGILL E + G PYP ++N++ E VE+G R+PCP+ CP ++ LM CW
Sbjct: 443 KSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKK 502
Query: 800 EPGQRPSFSTIYQELQ 815
+P +RP+F + L+
Sbjct: 503 DPEERPTFEYLQSFLE 518
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 224 bits (571), Expect = 3e-58
Identities = 141/374 (37%), Positives = 206/374 (55%), Gaps = 26/374 (6%)
Query: 460 WYHGAIPRAEVAELLV--HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLE 516
W+HG I R + LL +G FLVRES +Y L V DG H+ I + ++
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141
Query: 517 GEG-FPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQI 567
E F ++ L++H S +P + V + W LN ++L L + I
Sbjct: 142 EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 201
Query: 568 GRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVC 626
G+G FG+V G R + VAVK + D A+ FL EA ++ Q H N+V+L+GV
Sbjct: 202 GKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQLRHSNLVQLLGVI 255
Query: 627 TQ-KQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDL 684
+ K +YIV E + G + +LR+ G L LL+ D MEYLE +HRDL
Sbjct: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315
Query: 685 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 744
AARN LV+E NV K+SDFG+++E + ++ ++PVKWTAPEAL ++S++SDVW
Sbjct: 316 AARNVLVSEDNVAKVSDFGLTKEAS-----STQDTGKLPVKWTAPEALREKKFSTKSDVW 370
Query: 745 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804
SFGILLWE +S G PYP + + VEKG ++ P+ CP AV+ +M+ CW + R
Sbjct: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMR 430
Query: 805 PSFSTIYQELQSIR 818
PSF + ++L+ I+
Sbjct: 431 PSFLQLREQLEHIK 444
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 224 bits (571), Expect = 3e-58
Identities = 141/374 (37%), Positives = 206/374 (55%), Gaps = 26/374 (6%)
Query: 460 WYHGAIPRAEVAELLV--HSGDFLVRESQGKQ-EYVLSVLWDGLPRHFIIQSLDNLYRLE 516
W+HG I R + LL +G FLVRES +Y L V DG H+ I + ++
Sbjct: 82 WFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSID 141
Query: 517 GEG-FPSIPLLIDHLLSTQ--------QPLTKKSGVVLHRAVPKDKWVLNHEDLVLGEQI 567
E F ++ L++H S +P + V + W LN ++L L + I
Sbjct: 142 EEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTI 201
Query: 568 GRGNFGEVFSGRLRADNTLVAVKSCRETLPPDLKAK-FLQEARILKQYSHPNIVRLIGVC 626
G+G FG+V G R + VAVK + D A+ FL EA ++ Q H N+V+L+GV
Sbjct: 202 GKGEFGDVMLGDYRGNK--VAVKCIKN----DATAQAFLAEASVMTQLRHSNLVQLLGVI 255
Query: 627 TQ-KQPIYIVMELVQGGDFLTFLRTEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDL 684
+ K +YIV E + G + +LR+ G L LL+ D MEYLE +HRDL
Sbjct: 256 VEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDL 315
Query: 685 AARNCLVTEKNVLKISDFGMSREEADGVYAASGGLRQVPVKWTAPEALNYGRYSSESDVW 744
AARN LV+E NV K+SDFG+++E + ++ ++PVKWTAPEAL ++S++SDVW
Sbjct: 316 AARNVLVSEDNVAKVSDFGLTKEAS-----STQDTGKLPVKWTAPEALREKKFSTKSDVW 370
Query: 745 SFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWAYEPGQR 804
SFGILLWE +S G PYP + + VEKG ++ P+ CP AV+ +M+ CW + R
Sbjct: 371 SFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMR 430
Query: 805 PSFSTIYQELQSIR 818
PSF + ++L+ I+
Sbjct: 431 PSFLQLREQLEHIK 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,667,878
Number of Sequences: 37866
Number of extensions: 1520719
Number of successful extensions: 9729
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 622
Number of HSP's successfully gapped in prelim test: 526
Number of HSP's that attempted gapping in prelim test: 6402
Number of HSP's gapped (non-prelim): 2169
length of query: 822
length of database: 18,247,518
effective HSP length: 111
effective length of query: 711
effective length of database: 14,044,392
effective search space: 9985562712
effective search space used: 9985562712
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.