Search of human proteins with 4503649

Search of human proteins with 4503649

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         969   0.0  
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          395   e-110
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   356   3e-98
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   350   1e-96
gi|4506115 protein C [Homo sapiens]                                   284   1e-76
gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [H...   190   3e-48
gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]           177   1e-44
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             177   1e-44
gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]           171   1e-42
gi|11415040 matriptase [Homo sapiens]                                 169   4e-42
gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]       168   1e-41
gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]        168   1e-41
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           161   1e-39
gi|4503635 coagulation factor II preproprotein [Homo sapiens]         161   1e-39
gi|110815798 ovochymase 1 [Homo sapiens]                              160   2e-39
gi|4506153 prostasin preproprotein [Homo sapiens]                     159   4e-39
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   159   5e-39
gi|223942069 enterokinase precursor [Homo sapiens]                    156   4e-38
gi|13994276 marapsin [Homo sapiens]                                   155   6e-38
gi|4758502 hyaluronan binding protein 2 preproprotein [Homo sapi...   155   7e-38
gi|4503627 coagulation factor XI precursor [Homo sapiens]             155   9e-38
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   151   1e-36
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   151   1e-36
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         151   1e-36
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       151   1e-36
gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]     150   2e-36
gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]          150   2e-36
gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]       150   2e-36
gi|11496281 kallikrein 13 precursor [Homo sapiens]                    149   4e-36
gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...   149   7e-36

>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  969 bits (2504), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 60
           MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
Sbjct: 1   MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL 60

Query: 61  ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP 120
           ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
Sbjct: 61  ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP 120

Query: 121 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR 180
           FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
Sbjct: 121 FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR 180

Query: 181 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW 240
           VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
Sbjct: 181 VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW 240

Query: 241 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII 300
           QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
Sbjct: 241 QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII 300

Query: 301 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF 360
           PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
Sbjct: 301 PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF 360

Query: 361 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE 420
           HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
Sbjct: 361 HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE 420

Query: 421 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 461
           GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
Sbjct: 421 GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT 461


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  395 bits (1016), Expect = e-110
 Identities = 208/464 (44%), Positives = 284/464 (61%), Gaps = 23/464 (4%)

Query: 14  LITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEE 73
           L++  L G LL  E ++F+  E AN IL R  R NS  LEE  +G+LERECMEE CS+EE
Sbjct: 9   LLSASLAGLLLLGE-SLFIRREQANNILARVTRANSF-LEEMKKGHLERECMEETCSYEE 66

Query: 74  AREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVT 133
           AREVFE++++T EFW +Y DGDQCE++PC N G CKD +  Y C C  GFEGKNCEL   
Sbjct: 67  AREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTR 126

Query: 134 --CNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQ----TS 187
             C++ NG C+QFC +   N VVCSC  GY LA+N K+C P  P+PCG+ ++ +     +
Sbjct: 127 KLCSLDNGDCDQFC-HEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVA 185

Query: 188 KLTRAETVFPD------VDYVNSTEAETILD----NITQSTQSFNDFTRVVGGEDAKPGQ 237
           + T +    PD       D  +    E   D    N TQ  +  N+ TR+VGG++ K G+
Sbjct: 186 QATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGE 245

Query: 238 FPWQVVL-NGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNV 296
            PWQ +L N + + FCGG+I++E +I+TAAHC+    +  V  G+ N E+ E  E    V
Sbjct: 246 CPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEV 305

Query: 297 IRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT-NIFLKFGSGYVSG 355
             +I H+ +      Y+ DIA+L L  P+     V P C+ ++++  +  +   +G VSG
Sbjct: 306 EVVIKHNRFTK--ETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSG 363

Query: 356 WGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPH 415
           +GR   KGR +  L+ L VP VDR +C  S+ F I  NMFCAG+     D+CQGDSGGPH
Sbjct: 364 FGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPH 423

Query: 416 VTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 459
           VT  + T F+TGI+SWGE CA KGKYGIYTKV+ ++ WI    K
Sbjct: 424 VTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMK 467


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  356 bits (913), Expect = 3e-98
 Identities = 186/461 (40%), Positives = 264/461 (57%), Gaps = 51/461 (11%)

Query: 11  SPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCS 70
           S  L  +CLL  L      VF+  E A+ +L+R +R N+  LEE   G+LEREC EE+CS
Sbjct: 3   SQALRLLCLLLGLQGCLAAVFVTQEEAHGVLHRRRRANAF-LEELRPGSLERECKEEQCS 61

Query: 71  FEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCEL 130
           FEEARE+F++ ERT  FW  Y DGDQC S+PC NGGSCKD + SY C+C   FEG+NCE 
Sbjct: 62  FEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCET 121

Query: 131 ----DVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQT 186
                + C  +NG CEQ+C +    K  C C EGY L  +  SC P V +PCG++ + + 
Sbjct: 122 HKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEK 181

Query: 187 SKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNG 246
              ++ +                                R+VGG+    G+ PWQV+L  
Sbjct: 182 RNASKPQG-------------------------------RIVGGKVCPKGECPWQVLLLV 210

Query: 247 KVDAFCGGSIVNEKWIVTAAHC---VETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHH 303
                CGG+++N  W+V+AAHC   ++    +  V GEH++ E +  EQ R V ++I   
Sbjct: 211 NGAQLCGGTLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPS 270

Query: 304 NYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK---EYTNIFLKFGSGYVSGWGRVF 360
            Y       NHDIALL L +P+VL  +V P+C+ ++   E T  F++F    VSGWG++ 
Sbjct: 271 TYVPGTT--NHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFS--LVSGWGQLL 326

Query: 361 HKGRSALVLQYLRVPLVDRATCLRSTKFT-----IYNNMFCAGFHEGGRDSCQGDSGGPH 415
            +G +AL L  L VP +    CL+ ++       I   MFCAG+ +G +DSC+GDSGGPH
Sbjct: 327 DRGATALELMVLNVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPH 386

Query: 416 VTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
            T   GT +LTGI+SWG+ CA  G +G+YT+VS+Y+ W+++
Sbjct: 387 ATHYRGTWYLTGIVSWGQGCATVGHFGVYTRVSQYIEWLQK 427


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  350 bits (899), Expect = 1e-96
 Identities = 180/442 (40%), Positives = 257/442 (58%), Gaps = 51/442 (11%)

Query: 30  VFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWK 89
           VF+  E A+ +L+R +R N+  LEE   G+LEREC EE+CSFEEARE+F++ ERT  FW 
Sbjct: 44  VFVTQEEAHGVLHRRRRANAF-LEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWI 102

Query: 90  QYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCEL----DVTCNIKNGRCEQFC 145
            Y DGDQC S+PC NGGSCKD + SY C+C   FEG+NCE      + C  +NG CEQ+C
Sbjct: 103 SYSDGDQCASSPCQNGGSCKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYC 162

Query: 146 KNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNST 205
            +    K  C C EGY L  +  SC P V +PCG++ + +    ++ +            
Sbjct: 163 SDHTGTKRSCRCHEGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQG----------- 211

Query: 206 EAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTA 265
                               R+VGG+    G+ PWQV+L       CGG+++N  W+V+A
Sbjct: 212 --------------------RIVGGKVCPKGECPWQVLLLVNGAQLCGGTLINTIWVVSA 251

Query: 266 AHC---VETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELD 322
           AHC   ++    +  V GEH++ E +  EQ R V ++I    Y       NHDIALL L 
Sbjct: 252 AHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTT--NHDIALLRLH 309

Query: 323 EPLVLNSYVTPICIADK---EYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDR 379
           +P+VL  +V P+C+ ++   E T  F++F    VSGWG++  +G +AL L  L VP +  
Sbjct: 310 QPVVLTDHVVPLCLPERTFSERTLAFVRFS--LVSGWGQLLDRGATALELMVLNVPRLMT 367

Query: 380 ATCLRSTKFT-----IYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEE 434
             CL+ ++       I   MFCAG+ +G +DSC+GDSGGPH T   GT +LTGI+SWG+ 
Sbjct: 368 QDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTGIVSWGQG 427

Query: 435 CAMKGKYGIYTKVSRYVNWIKE 456
           CA  G +G+YT+VS+Y+ W+++
Sbjct: 428 CATVGHFGVYTRVSQYIEWLQK 449


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  284 bits (727), Expect = 1e-76
 Identities = 159/447 (35%), Positives = 235/447 (52%), Gaps = 47/447 (10%)

Query: 29  TVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFW 88
           +VF   E A+++L   KR NS  LEE    +LEREC+EE C FEEA+E+F+N + T  FW
Sbjct: 25  SVFSSSERAHQVLRIRKRANSF-LEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFW 83

Query: 89  KQYVDGDQCESNP--------CLNGGSCKDDINSYECWCPFGFEGKNCELDVT---CNIK 137
            ++VDGDQC   P        C   G+C D I S+ C C  G+EG+ C+ +V+   C++ 
Sbjct: 84  SKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLD 143

Query: 138 NGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFP 197
           NG C  +C      +  CSC  GY+L ++   C PAV FPCGR       K +  +    
Sbjct: 144 NGGCTHYCLEEVGWRR-CSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKR--- 199

Query: 198 DVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVL-NGKVDAFCGGSI 256
                ++ + E  +D             R++ G+  + G  PWQVVL + K    CG  +
Sbjct: 200 -----DTEDQEDQVD------------PRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVL 242

Query: 257 VNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDI 316
           ++  W++TAAHC++   K+ V  GE+++   E  E   ++  +  H NY+ +    ++DI
Sbjct: 243 IHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTT--DNDI 300

Query: 317 ALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSG--YVSGWGRVFHKGRS-------AL 367
           ALL L +P  L+  + PIC+ D       L        V+GWG  +H  R          
Sbjct: 301 ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWG--YHSSREKEAKRNRTF 358

Query: 368 VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTG 427
           VL ++++P+V    C       +  NM CAG     +D+C+GDSGGP V    GT FL G
Sbjct: 359 VLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVG 418

Query: 428 IISWGEECAMKGKYGIYTKVSRYVNWI 454
           ++SWGE C +   YG+YTKVSRY++WI
Sbjct: 419 LVSWGEGCGLLHNYGVYTKVSRYLDWI 445


>gi|4506121 protein Z, vitamin K-dependent plasma glycoprotein [Homo
           sapiens]
          Length = 400

 Score =  190 bits (482), Expect = 3e-48
 Identities = 140/449 (31%), Positives = 200/449 (44%), Gaps = 61/449 (13%)

Query: 12  PGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSF 71
           P L  + L+  L   E +VFL    AN +L R KR  S  LEE  +GNLE+EC EE C +
Sbjct: 6   PLLQGLVLVLALHRVEPSVFLPASKANDVLVRWKRAGSYLLEELFEGNLEKECYEEICVY 65

Query: 72  EEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELD 131
           EEAREVFEN   T EFW++Y  G  C S PCL+ GSC+D I  Y C C  G+EG NCEL 
Sbjct: 66  EEAREVFENEVVTDEFWRRYKGGSPCISQPCLHNGSCQDSIWGYTCTCSPGYEGSNCELA 125

Query: 132 VT-CN-IKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKL 189
              C+  +   C+ FC    ++   CSC +GYRL E+ K C P     CG         +
Sbjct: 126 KNECHPERTDGCQHFCLPGQES-YTCSCAQGYRLGEDHKQCVPHDQCACG---------V 175

Query: 190 TRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVL-NGKV 248
             +E   PD+                                       PWQV L N + 
Sbjct: 176 LTSEKRAPDLQ------------------------------------DLPWQVKLTNSEG 199

Query: 249 DAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAA 308
             FCGG I+ E +++T A C      ITV   +     T        +  +  H  Y+A 
Sbjct: 200 KDFCGGVIIRENFVLTTAKCSLLHRNITV---KTYFNRTSQDPLMIKITHVHVHMRYDAD 256

Query: 309 INKYNHDIALLELDEPLVLNSYVTPICIADKEYT-NIFLKFGSGYVSGWGRVFHKGRSAL 367
             +  +D++LLEL+ P+       P+C  +K++  ++ +    G +SGW R      ++L
Sbjct: 257 AGE--NDLSLLELEWPIQCPGAGLPVCTPEKDFAEHLLIPRTRGLLSGWARNGTDLGNSL 314

Query: 368 VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTG 427
             +   V LV+   C +    T+    +C         +     G     E  G+ FLTG
Sbjct: 315 TTR--PVTLVEGEECGQVLNVTVTTRTYC---ERSSVAAMHWMDGSVVTREHRGSWFLTG 369

Query: 428 IISWGEECAMKGKYGIYTKVSRYVNWIKE 456
           ++   +    +    + TKVSRY  W K+
Sbjct: 370 VLG-SQPVGGQAHMVLVTKVSRYSLWFKQ 397


>gi|4506147 protease, serine, 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  177 bits (450), Expect = 1e-44
 Identities = 101/237 (42%), Positives = 138/237 (58%), Gaps = 14/237 (5%)

Query: 221 FNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG 280
           F+D  ++VGG   +    P+QV LN     FCGGS+++E+W+V+A HC ++ +++ +  G
Sbjct: 18  FDDDDKIVGGYICEENSVPYQVSLNSGYH-FCGGSLISEQWVVSAGHCYKSRIQVRL--G 74

Query: 281 EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKE 340
           EHNIE  E  EQ  N  +II H  YN+     ++DI L++L  P V+NS V+ I +    
Sbjct: 75  EHNIEVLEGNEQFINAAKIIRHPKYNS--RTLDNDILLIKLSSPAVINSRVSAISLP--- 129

Query: 341 YTNIFLKFGSGYVSGWGRVFHKGRSAL-VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF 399
            T          +SGWG     G      LQ L  P++ +A C  S    I NNMFC GF
Sbjct: 130 -TAPPAAGTESLISGWGNTLSSGADYPDELQCLDAPVLSQAECEASYPGKITNNMFCVGF 188

Query: 400 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
            EGG+DSCQGDSGGP V+  E    L GI+SWG  CA K + G+YTKV  YV+WIK+
Sbjct: 189 LEGGKDSCQGDSGGPVVSNGE----LQGIVSWGYGCAQKNRPGVYTKVYNYVDWIKD 241


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  177 bits (450), Expect = 1e-44
 Identities = 96/243 (39%), Positives = 143/243 (58%), Gaps = 13/243 (5%)

Query: 225 TRVVGGEDAKPGQFPWQVVLNGKVDA---FCGGSIVNEKWIVTAAHCVETGVKIT----V 277
           TR+VGG ++  G++PWQV L  K+ A    CGGS++  +W++TAAHC + G+ +     +
Sbjct: 389 TRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFD-GLPLQDVWRI 447

Query: 278 VAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIA 337
            +G  N+ +         +  II H NY   +++ NHDIAL++L  PL    +  PIC+ 
Sbjct: 448 YSGILNLSDITKDTPFSQIKEIIIHQNYK--VSEGNHDIALIKLQAPLNYTEFQKPICLP 505

Query: 338 DKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCL-RSTKFTIYNNMFC 396
            K  T+    + + +V+GWG    KG    +LQ + +PLV    C  R   + I   M C
Sbjct: 506 SKGDTSTI--YTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVC 563

Query: 397 AGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
           AG+ EGG+D+C+GDSGGP V +  G   L GI SWGE CA + + G+YTKV+ Y++WI E
Sbjct: 564 AGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILE 623

Query: 457 KTK 459
           KT+
Sbjct: 624 KTQ 626


>gi|4506145 protease, serine, 1 preproprotein [Homo sapiens]
          Length = 247

 Score =  171 bits (433), Expect = 1e-42
 Identities = 98/237 (41%), Positives = 136/237 (57%), Gaps = 16/237 (6%)

Query: 221 FNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG 280
           F+D  ++VGG + +    P+QV LN     FCGGS++NE+W+V+A HC ++ +++ +  G
Sbjct: 18  FDDDDKIVGGYNCEENSVPYQVSLNSGYH-FCGGSLINEQWVVSAGHCYKSRIQVRL--G 74

Query: 281 EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKE 340
           EHNIE  E  EQ  N  +II H  Y+      N+DI L++L    V+N+ V+ I +    
Sbjct: 75  EHNIEVLEGNEQFINAAKIIRHPQYDR--KTLNNDIMLIKLSSRAVINARVSTISLPTAP 132

Query: 341 YTNIFLKFGSG-YVSGWGRVFHKGRSAL-VLQYLRVPLVDRATCLRSTKFTIYNNMFCAG 398
                   G+   +SGWG     G      LQ L  P++ +A C  S    I +NMFC G
Sbjct: 133 PAT-----GTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVG 187

Query: 399 FHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIK 455
           F EGG+DSCQGDSGGP V   +    L G++SWG+ CA K K G+YTKV  YV WIK
Sbjct: 188 FLEGGKDSCQGDSGGPVVCNGQ----LQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK 240


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  169 bits (429), Expect = 4e-42
 Identities = 117/371 (31%), Positives = 178/371 (47%), Gaps = 39/371 (10%)

Query: 102 CLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRC---EQFCKNSADNKVVCSCT 158
           C +   C D+ +   C CP            T    NG+C    Q C    D      C 
Sbjct: 508 CDSVNDCGDNSDEQGCSCPAQ----------TFRCSNGKCLSKSQQCNGKDD------CG 551

Query: 159 EGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQST 218
           +G     ++ SC       C + +    + L  ++   P+ D        +   +     
Sbjct: 552 DG----SDEASCPKVNVVTCTKHTYRCLNGLCLSKGN-PECDGKEDCSDGSDEKDCDCGL 606

Query: 219 QSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDA-FCGGSIVNEKWIVTAAHCV--ETGVKI 275
           +SF    RVVGG DA  G++PWQV L+       CG S+++  W+V+AAHC   + G + 
Sbjct: 607 RSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRY 666

Query: 276 ------TVVAGEHN-IEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLN 328
                 T   G H+  + +    Q+R + RII H  +N     +++DIALLEL++P   +
Sbjct: 667 SDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFT--FDYDIALLELEKPAEYS 724

Query: 329 SYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKF 388
           S V PIC+ D  +  +F    + +V+GWG   + G  AL+LQ   + ++++ TC      
Sbjct: 725 SMVRPICLPDASH--VFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ 782

Query: 389 TIYNNMFCAGFHEGGRDSCQGDSGGP-HVTEVEGTSFLTGIISWGEECAMKGKYGIYTKV 447
            I   M C GF  GG DSCQGDSGGP    E +G  F  G++SWG+ CA + K G+YT++
Sbjct: 783 QITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRL 842

Query: 448 SRYVNWIKEKT 458
             + +WIKE T
Sbjct: 843 PLFRDWIKENT 853


>gi|170296790 mesotrypsin isoform 1 preproprotein [Homo sapiens]
          Length = 304

 Score =  168 bits (425), Expect = 1e-41
 Identities = 96/237 (40%), Positives = 137/237 (57%), Gaps = 14/237 (5%)

Query: 221 FNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG 280
           F+D  ++VGG   +    P+QV LN     FCGGS+++E+W+V+AAHC +T +++ +  G
Sbjct: 75  FDDDDKIVGGYTCEENSLPYQVSLNSG-SHFCGGSLISEQWVVSAAHCYKTRIQVRL--G 131

Query: 281 EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKE 340
           EHNI+  E  EQ  N  +II H  YN   +  ++DI L++L  P V+N+ V+ I +    
Sbjct: 132 EHNIKVLEGNEQFINAAKIIRHPKYNR--DTLDNDIMLIKLSSPAVINARVSTISLP--- 186

Query: 341 YTNIFLKFGSGYVSGWGRVFHKGRSAL-VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF 399
            T          +SGWG     G      L+ L  P++ +A C  S    I N+MFC GF
Sbjct: 187 -TAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGF 245

Query: 400 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
            EGG+DSCQ DSGGP V   +    L G++SWG  CA K + G+YTKV  YV+WIK+
Sbjct: 246 LEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKD 298


>gi|21536452 mesotrypsin isoform 2 preproprotein [Homo sapiens]
          Length = 247

 Score =  168 bits (425), Expect = 1e-41
 Identities = 96/237 (40%), Positives = 137/237 (57%), Gaps = 14/237 (5%)

Query: 221 FNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAG 280
           F+D  ++VGG   +    P+QV LN     FCGGS+++E+W+V+AAHC +T +++ +  G
Sbjct: 18  FDDDDKIVGGYTCEENSLPYQVSLNSG-SHFCGGSLISEQWVVSAAHCYKTRIQVRL--G 74

Query: 281 EHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKE 340
           EHNI+  E  EQ  N  +II H  YN   +  ++DI L++L  P V+N+ V+ I +    
Sbjct: 75  EHNIKVLEGNEQFINAAKIIRHPKYNR--DTLDNDIMLIKLSSPAVINARVSTISLP--- 129

Query: 341 YTNIFLKFGSGYVSGWGRVFHKGRSAL-VLQYLRVPLVDRATCLRSTKFTIYNNMFCAGF 399
            T          +SGWG     G      L+ L  P++ +A C  S    I N+MFC GF
Sbjct: 130 -TAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKASYPGKITNSMFCVGF 188

Query: 400 HEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
            EGG+DSCQ DSGGP V   +    L G++SWG  CA K + G+YTKV  YV+WIK+
Sbjct: 189 LEGGKDSCQRDSGGPVVCNGQ----LQGVVSWGHGCAWKNRPGVYTKVYNYVDWIKD 241


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  161 bits (408), Expect = 1e-39
 Identities = 91/238 (38%), Positives = 132/238 (55%), Gaps = 9/238 (3%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHC---VETGVKITVVAGEH 282
           R+VGG +A PG+FPWQ  L    + FCG +I+N +W+V+AAHC    +   K     G  
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVGAT 261

Query: 283 NIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT 342
            +  +E +  +  V++I+ H  YNA  +  + D+A+LEL  PL    ++ P+C+     T
Sbjct: 262 YLSGSEASTVRAQVVQIVKHPLYNA--DTADFDVAVLELTSPLPFGRHIQPVCL--PAAT 317

Query: 343 NIFLKFGSGYVSGWGRVFHKGR-SALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHE 401
           +IF       +SGWG +         VLQ   V L+D+A C      ++ + M CAG+ +
Sbjct: 318 HIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCASLYGHSLTDRMVCAGYLD 377

Query: 402 GGRDSCQGDSGGPHV-TEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKT 458
           G  DSCQGDSGGP V  E  G  FL GI+SWG  CA   + G+Y +V+R  +WI E T
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILEAT 435



 Score =  151 bits (382), Expect = 1e-36
 Identities = 92/240 (38%), Positives = 130/240 (54%), Gaps = 16/240 (6%)

Query: 225 TRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCV-ETGV-KITVVAGEH 282
           TRVVGG  A  G+ PWQV L      FCG ++V ++W+++AAHC   T V ++    G  
Sbjct: 502 TRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHTKVEQVRAHLGTA 561

Query: 283 NIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT 342
           ++     +  K  + R++ H  YN  I   + D+A+LEL  PL  N Y+ P+C+      
Sbjct: 562 SLLGLGGSPVKIGLRRVVLHPLYNPGI--LDFDLAVLELASPLAFNKYIQPVCL-----P 614

Query: 343 NIFLKFGSG---YVSGWGRVFHKGRSAL--VLQYLRVPLVDRATCLRSTKFTIYNNMFCA 397
               KF  G    +SGWG    +G +    +LQ   V ++D+ TC     F++ + M CA
Sbjct: 615 LAIQKFPVGRKCMISGWGNT-QEGNATKPELLQKASVGIIDQKTCSVLYNFSLTDRMICA 673

Query: 398 GFHEGGRDSCQGDSGGP-HVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKE 456
           GF EG  DSCQGDSGGP    E  G  +L GI+SWG  CA   K G+YT+++R   WI E
Sbjct: 674 GFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGWILE 733



 Score =  129 bits (324), Expect = 6e-30
 Identities = 95/283 (33%), Positives = 134/283 (47%), Gaps = 27/283 (9%)

Query: 182  SVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQ 241
            ++S  S   R +T FPD     +    T L +   +  +    TR+VGG  A  G++PWQ
Sbjct: 788  TLSAVSTTARGQTPFPDAPEATT---HTQLPDCGLAPAAL---TRIVGGSAAGRGEWPWQ 841

Query: 242  VVL-NGKVDAFCGGSIVNEKWIVTAAHCVET---GVKITVVAGEHNIEETEHTEQKRNVI 297
            V L   + +  CG  +V E+W+++AAHC +      +     G   +   E   Q   V 
Sbjct: 842  VSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQWAAFLGTPFLSGAEG--QLERVA 899

Query: 298  RIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK-----EYTNIFLKFGSGY 352
            RI  H  YN  +   ++D+ALLEL  P+  +  V PIC+ +      + T          
Sbjct: 900  RIYKHPFYN--LYTLDYDVALLELAGPVRRSRLVRPICLPEPAPRPPDGTRCV------- 950

Query: 353  VSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSG 412
            ++GWG V   G  A  LQ   V L+   TC R     I + M CAGF +GG DSC GD+G
Sbjct: 951  ITGWGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFPQGGVDSCSGDAG 1010

Query: 413  GP-HVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWI 454
            GP    E  G   LTG+ SWG  C      G+YT+V+    WI
Sbjct: 1011 GPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053


>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
          Length = 622

 Score =  161 bits (407), Expect = 1e-39
 Identities = 97/255 (38%), Positives = 147/255 (57%), Gaps = 26/255 (10%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKV--DAFCGGSIVNEKWIVTAAHCVE--------TGVKI 275
           R+V G DA+ G  PWQV+L  K   +  CG S+++++W++TAAHC+         T   +
Sbjct: 363 RIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDL 422

Query: 276 TVVAGEHNIEETEHTEQKRNVI-RIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPI 334
            V  G+H+    E   +K +++ +I  H  YN   N  + DIAL++L +P+  + Y+ P+
Sbjct: 423 LVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWREN-LDRDIALMKLKKPVAFSDYIHPV 481

Query: 335 CIADKEYTNIFLKFG-SGYVSGWGRVFH-------KGRSALVLQYLRVPLVDRATCLRST 386
           C+ D+E     L+ G  G V+GWG +         KG+ + VLQ + +P+V+R  C  ST
Sbjct: 482 CLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPS-VLQVVNLPIVERPVCKDST 540

Query: 387 KFTIYNNMFCAGFH--EGGR-DSCQGDSGGPHVTEVEGTS--FLTGIISWGEECAMKGKY 441
           +  I +NMFCAG+   EG R D+C+GDSGGP V +    +  +  GI+SWGE C   GKY
Sbjct: 541 RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY 600

Query: 442 GIYTKVSRYVNWIKE 456
           G YT V R   WI++
Sbjct: 601 GFYTHVFRLKKWIQK 615



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 44/127 (34%), Positives = 63/127 (49%), Gaps = 13/127 (10%)

Query: 12  PGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSF 71
           PG + +  L  L+ ++  VFL  + A  +L R +R N+  LEE  +GNLEREC+EE CS+
Sbjct: 10  PGCLALAALCSLVHSQ-HVFLAPQQARSLLQRVRRANTF-LEEVRKGNLERECVEETCSY 67

Query: 72  EEAREVFENTERTTEFWKQYVDGDQCES--------NPCLNGGSCKDDINSYECWCPFGF 123
           EEA E  E++  T  FW +Y     CE+          CL G   +    +Y        
Sbjct: 68  EEAFEALESSTATDVFWAKYT---ACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITR 124

Query: 124 EGKNCEL 130
            G  C+L
Sbjct: 125 SGIECQL 131


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  160 bits (405), Expect = 2e-39
 Identities = 95/242 (39%), Positives = 134/242 (55%), Gaps = 15/242 (6%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVE---TGVKITVVAGEH 282
           R+ GGE+A P  +PWQV L    D  CGG+I+N  WI+TAAHCV+     +  T++AG+H
Sbjct: 574 RIAGGEEACPHCWPWQVGLRFLGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDH 633

Query: 283 NIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT 342
           +    E TEQ R    II H ++N     Y+ DIAL++L  PL  NS V P+C+      
Sbjct: 634 DRNLKESTEQVRRAKHIIVHEDFNTL--SYDSDIALIQLSSPLEYNSVVRPVCLPHSAEP 691

Query: 343 NIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFT-----IYNNMFCA 397
               +  +  V+GWG +   G  A  LQ ++V +++R  C   T ++     I   M CA
Sbjct: 692 LFSSEICA--VTGWGSISADGGLASRLQQIQVHVLEREVC-EHTYYSAHPGGITEKMICA 748

Query: 398 GFHEGG-RDSCQGDSGGPHVTEVEGTSF-LTGIISWGEECAMKGKYGIYTKVSRYVNWIK 455
           GF   G +D CQGDSGGP V   E   F L GI+SWG  C    K G++ +V  +++WI+
Sbjct: 749 GFAASGEKDFCQGDSGGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQ 808

Query: 456 EK 457
            K
Sbjct: 809 SK 810



 Score =  130 bits (327), Expect = 3e-30
 Identities = 88/256 (34%), Positives = 132/256 (51%), Gaps = 29/256 (11%)

Query: 224 FTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVK-----ITVV 278
           F+R+    ++     PWQV L      FCGGS++ E  +VTAAHC+++  +     ITV 
Sbjct: 44  FSRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITVT 103

Query: 279 AGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIAD 338
           +GE+++ + +  EQ   V +II H  YN+     + DIALL L   +   + V PIC+ D
Sbjct: 104 SGEYSLFQKDKQEQNIPVSKIITHPEYNSR-EYMSPDIALLYLKHKVKFGNAVQPICLPD 162

Query: 339 KEYTNIFLKFGSGYV---SGWGRVFHKGRSALVLQYLRVPLVDRATC---LRSTKF-TIY 391
            +      K   G +   SGWG++      + VLQ + +P++D   C   L+S     + 
Sbjct: 163 SDD-----KVEPGILCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLG 217

Query: 392 NNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSF-LTGIISWGEECA----------MKGK 440
             M CAGF + G D+CQGDSGGP V    G  + L GI SW   CA          +K  
Sbjct: 218 RTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKAS 277

Query: 441 YGIYTKVSRYVNWIKE 456
            GI++KVS  +++I +
Sbjct: 278 LGIFSKVSELMDFITQ 293


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  159 bits (403), Expect = 4e-39
 Identities = 91/248 (36%), Positives = 132/248 (53%), Gaps = 23/248 (9%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETG---VKITVVAGEH 282
           R+ GG  A  GQ+PWQV +  +    CGGS+V+E+W+++AAHC  +        V  G H
Sbjct: 44  RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGAH 103

Query: 283 NIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYT 342
            ++      +   +  IIPH +Y    ++   DIALL+L  P+  + Y+ PIC+     +
Sbjct: 104 QLDSYSEDAKVSTLKDIIPHPSYLQEGSQ--GDIALLQLSRPITFSRYIRPICLPAANAS 161

Query: 343 NIFLKFGSGY---VSGWGRVFHKGR--SALVLQYLRVPLVDRATC--------LRSTKFT 389
                F +G    V+GWG V       +   LQ L VPL+ R TC               
Sbjct: 162 -----FPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHF 216

Query: 390 IYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSR 449
           +  +M CAG+ EGG+D+CQGDSGGP    VEG  +LTGI+SWG+ C  + + G+YT  S 
Sbjct: 217 VQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASS 276

Query: 450 YVNWIKEK 457
           Y +WI+ K
Sbjct: 277 YASWIQSK 284


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  159 bits (402), Expect = 5e-39
 Identities = 95/273 (34%), Positives = 148/273 (54%), Gaps = 42/273 (15%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDA-------FCGGSIVNEKWIVTAAHCVETGVK---- 274
           R++GG +A+PG FPWQ ++  +  +       F  G++++  WI+TAAH + +  +    
Sbjct: 449 RIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTV 508

Query: 275 -------ITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVL 327
                  +TV  G H++ +        +  R++ H ++N  I  YNHDIAL++L EP+ L
Sbjct: 509 IPVSKEHVTVYLGLHDVRDKSGAVNS-SAARVVLHPDFN--IQNYNHDIALVQLQEPVPL 565

Query: 328 NSYVTPICIADKEYTNIFLKFGSGYVSGWG---------RVFHKGRSAL--VLQYLRVPL 376
             +V P+C+   E          G V+GWG          +   G   L  VLQY+++P+
Sbjct: 566 GPHVMPVCLPRLEPEGPAPHM-LGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPV 624

Query: 377 VDRATCL-----RSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHV--TEVEGTSFLTGII 429
           V  A C      RS  +++  NMFCAG++EGG+D+C GDSGG  V   ++     + G++
Sbjct: 625 VPHAECKTSYESRSGNYSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQRWVVQGLV 684

Query: 430 SWG--EECAMKGKYGIYTKVSRYVNWIKEKTKL 460
           SWG  EEC  K  YG+YTKVS YV+W+ E+  L
Sbjct: 685 SWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGL 717



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 22/71 (30%), Positives = 31/71 (43%), Gaps = 9/71 (12%)

Query: 75  REVFENTERTTEFWKQY--VDGDQC---ESNPCLNGGSCKDDINSYECWCPFGF----EG 125
           R  F N ER T F   Y  VD D+C   E         C + I  Y C C FG+    + 
Sbjct: 119 RSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDN 178

Query: 126 KNCELDVTCNI 136
           + C ++ + N+
Sbjct: 179 RTCRVECSDNL 189


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  156 bits (394), Expect = 4e-38
 Identities = 85/238 (35%), Positives = 134/238 (56%), Gaps = 14/238 (5%)

Query: 226  RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVE----TGVKITVVAGE 281
            ++VGG +AK G +PW V L       CG S+V+  W+V+AAHCV        K T + G 
Sbjct: 784  KIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGL 843

Query: 282  H---NIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIAD 338
            H   N+   +   +  + I I PH+N      + ++DIA++ L+  +    Y+ PIC+ +
Sbjct: 844  HMKSNLTSPQTVPRLIDEIVINPHYNRR----RKDNDIAMMHLEFKVNYTDYIQPICLPE 899

Query: 339  KEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRST-KFTIYNNMFCA 397
            +    +F    +  ++GWG V ++G +A +LQ   VPL+    C +   ++ I  NM CA
Sbjct: 900  EN--QVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQQQMPEYNITENMICA 957

Query: 398  GFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIK 455
            G+ EGG DSCQGDSGGP + +     FL G+ S+G +CA+  + G+Y +VSR+  WI+
Sbjct: 958  GYEEGGIDSCQGDSGGPLMCQENNRWFLAGVTSFGYKCALPNRPGVYARVSRFTEWIQ 1015


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  155 bits (393), Expect = 6e-38
 Identities = 87/244 (35%), Positives = 137/244 (56%), Gaps = 20/244 (8%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCV----ETGVKITVVAGE 281
           R+VGG+D + G++PWQV +      FCGGS++ E+W++TAAHC     ET +   ++   
Sbjct: 34  RMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLGAR 93

Query: 282 HNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEY 341
             ++   H    R V ++  +  Y    +  + D+AL+EL+ P+   +Y+ P+C+ D   
Sbjct: 94  QLVQPGPHAMYAR-VRQVESNPLYQGTAS--SADVALVELEAPVPFTNYILPVCLPDPSV 150

Query: 342 TNIFLKFGSGYVSGWGRVFHKGR--SALVLQYLRVPLVDRATC----LRSTKF-----TI 390
             IF    + +V+GWG    +       +LQ L VP++D   C     + T+F     TI
Sbjct: 151 --IFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTI 208

Query: 391 YNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRY 450
            N+M CAGF EG +D+C+GDSGGP V  V  +    G+ISWGE CA + + G+Y +V+ +
Sbjct: 209 KNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAH 268

Query: 451 VNWI 454
            NWI
Sbjct: 269 HNWI 272


>gi|4758502 hyaluronan binding protein 2 preproprotein [Homo
           sapiens]
          Length = 560

 Score =  155 bits (392), Expect = 7e-38
 Identities = 115/410 (28%), Positives = 188/410 (45%), Gaps = 55/410 (13%)

Query: 97  CESNPCLNGGSCKDDI--NSYECWCPFGFEGKNCELDVT-CNIKNGRCEQFCKNSADNKV 153
           C  NPC NG +C      + + C CP  F+GK CE+    C + +G   +   N   N+ 
Sbjct: 154 CRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQH 213

Query: 154 VCS-------CTEGYRL--------------------AENQKSCEPAVPFPCGRVSVSQT 186
            C          E Y +                    A+ +  C   V     +      
Sbjct: 214 ACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDV 273

Query: 187 SKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNG 246
           S  +  +  +P+      +      D+  ++  +     R+ GG  +  G+ PWQ  L  
Sbjct: 274 SACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQS 333

Query: 247 KVDA--------FCGGSIVNEKWIVTAAHCVETGVK-ITVVAGEHNIEETEHTEQKRNVI 297
            +          FCGG++++  W++TAAHC +   + + VV G+ ++++ E  EQ   V 
Sbjct: 334 SLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVE 393

Query: 298 RIIPHHNYNAAINKYNHDIALLEL---DEPLVLNS-YVTPICIADKEYTNIFLKFGSG-Y 352
           +I  + +YN      ++DIALL+L   D    L S YV  +C+ D  + +     GS  +
Sbjct: 394 KIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPS-----GSECH 448

Query: 353 VSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFT--IYNNMFCAG-FHEGGRDSCQG 409
           +SGWG V   G+ +  L   +V L+    C     +   I ++M CAG   + G+D+CQG
Sbjct: 449 ISGWG-VTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQG 507

Query: 410 DSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTK 459
           DSGGP   E +GT ++ GI+SWG EC  +   G+YT+V++++NWIK   K
Sbjct: 508 DSGGPLTCEKDGTYYVYGIVSWGLECGKRP--GVYTQVTKFLNWIKATIK 555



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 17/65 (26%), Positives = 29/65 (44%), Gaps = 10/65 (15%)

Query: 95  DQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVV 154
           D C+ NPC +GG C    +++ C C   F G  C+          + +  CK++   +  
Sbjct: 75  DPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQ----------KVQNTCKDNPCGRGQ 124

Query: 155 CSCTE 159
           C  T+
Sbjct: 125 CLITQ 129


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  155 bits (391), Expect = 9e-38
 Identities = 92/241 (38%), Positives = 130/241 (53%), Gaps = 11/241 (4%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDA---FCGGSIVNEKWIVTAAHC---VETGVKITVVA 279
           R+VGG  +  G++PWQV L+         CGGSI+  +WI+TAAHC   VE+   + V +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446

Query: 280 GEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADK 339
           G  N  E +       V  II H  Y  A + Y  DIALL+L+  +       PIC+  K
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGY--DIALLKLETTVNYTDSQRPICLPSK 504

Query: 340 EYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTK-FTIYNNMFCAG 398
              N+   +   +V+GWG    + +    LQ  ++PLV    C +  +   I + M CAG
Sbjct: 505 GDRNVI--YTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKMICAG 562

Query: 399 FHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKT 458
           + EGG+D+C+GDSGGP   +      L GI SWGE CA + + G+YT V  YV+WI EKT
Sbjct: 563 YREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKT 622

Query: 459 K 459
           +
Sbjct: 623 Q 623


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/251 (37%), Positives = 136/251 (54%), Gaps = 22/251 (8%)

Query: 213 NITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETG 272
           N+  S QS     R+VGGE A PG +PWQV L+ +    CGGSI+  +WIVTAAHCVE  
Sbjct: 284 NLNSSRQS-----RIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 338

Query: 273 VKI----TVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLN 328
           +      T  AG    +          V ++I H NY++     N+DIAL++L +PL  N
Sbjct: 339 LNNPWHWTAFAGILR-QSFMFYGAGYQVEKVISHPNYDSKTK--NNDIALMKLQKPLTFN 395

Query: 329 SYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKF 388
             V P+C+ +     +       ++SGWG    KG+++ VL   +V L++   C  ++++
Sbjct: 396 DLVKPVCLPNPGM--MLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRY 451

Query: 389 TIYNN-----MFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGI 443
            +Y+N     M CAGF +G  DSCQGDSGGP VT      +L G  SWG  CA   + G+
Sbjct: 452 -VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGV 510

Query: 444 YTKVSRYVNWI 454
           Y  V  + +WI
Sbjct: 511 YGNVMVFTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  151 bits (382), Expect = 1e-36
 Identities = 95/251 (37%), Positives = 136/251 (54%), Gaps = 22/251 (8%)

Query: 213 NITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETG 272
           N+  S QS     R+VGGE A PG +PWQV L+ +    CGGSI+  +WIVTAAHCVE  
Sbjct: 247 NLNSSRQS-----RIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKP 301

Query: 273 VKI----TVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLN 328
           +      T  AG    +          V ++I H NY++     N+DIAL++L +PL  N
Sbjct: 302 LNNPWHWTAFAGILR-QSFMFYGAGYQVEKVISHPNYDSKTK--NNDIALMKLQKPLTFN 358

Query: 329 SYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKF 388
             V P+C+ +     +       ++SGWG    KG+++ VL   +V L++   C  ++++
Sbjct: 359 DLVKPVCLPNPGM--MLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRC--NSRY 414

Query: 389 TIYNN-----MFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGI 443
            +Y+N     M CAGF +G  DSCQGDSGGP VT      +L G  SWG  CA   + G+
Sbjct: 415 -VYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGV 473

Query: 444 YTKVSRYVNWI 454
           Y  V  + +WI
Sbjct: 474 YGNVMVFTDWI 484


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  151 bits (382), Expect = 1e-36
 Identities = 88/262 (33%), Positives = 139/262 (53%), Gaps = 10/262 (3%)

Query: 202 VNSTEAETILDNI--TQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNE 259
           +N TE ++ L++   T+ +++     R+VGG + + G++PWQ  L       CG +++N 
Sbjct: 165 INKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINA 224

Query: 260 KWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALL 319
            W+V+AAHC  T            +   + ++ KR + RII H  Y      +++DI+L 
Sbjct: 225 TWLVSAAHCFTTYKNPARWTASFGV-TIKPSKMKRGLRRIIVHEKYKHP--SHDYDISLA 281

Query: 320 ELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDR 379
           EL  P+   + V  +C+ D  Y   F      +V+G+G + + G S   L+  +V L+D 
Sbjct: 282 ELSSPVPYTNAVHRVCLPDASYE--FQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDA 339

Query: 380 ATCLRSTKF--TIYNNMFCAGFHEGGRDSCQGDSGGPHV-TEVEGTSFLTGIISWGEECA 436
            TC     +   I   M CAG  EG  D+CQGDSGGP V ++     +L GI+SWG+ECA
Sbjct: 340 TTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECA 399

Query: 437 MKGKYGIYTKVSRYVNWIKEKT 458
              K G+YT+V+   +WI  KT
Sbjct: 400 KPNKPGVYTRVTALRDWITSKT 421


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  151 bits (382), Expect = 1e-36
 Identities = 88/262 (33%), Positives = 139/262 (53%), Gaps = 10/262 (3%)

Query: 202 VNSTEAETILDNI--TQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNE 259
           +N TE ++ L++   T+ +++     R+VGG + + G++PWQ  L       CG +++N 
Sbjct: 165 INKTETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINA 224

Query: 260 KWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALL 319
            W+V+AAHC  T            +   + ++ KR + RII H  Y      +++DI+L 
Sbjct: 225 TWLVSAAHCFTTYKNPARWTASFGV-TIKPSKMKRGLRRIIVHEKYKHP--SHDYDISLA 281

Query: 320 ELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDR 379
           EL  P+   + V  +C+ D  Y   F      +V+G+G + + G S   L+  +V L+D 
Sbjct: 282 ELSSPVPYTNAVHRVCLPDASYE--FQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDA 339

Query: 380 ATCLRSTKF--TIYNNMFCAGFHEGGRDSCQGDSGGPHV-TEVEGTSFLTGIISWGEECA 436
            TC     +   I   M CAG  EG  D+CQGDSGGP V ++     +L GI+SWG+ECA
Sbjct: 340 TTCNEPQAYNDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECA 399

Query: 437 MKGKYGIYTKVSRYVNWIKEKT 458
              K G+YT+V+   +WI  KT
Sbjct: 400 KPNKPGVYTRVTALRDWITSKT 421


>gi|209862865 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  150 bits (379), Expect = 2e-36
 Identities = 84/239 (35%), Positives = 130/239 (54%), Gaps = 14/239 (5%)

Query: 225 TRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNI 284
           TR++ G + KP   PWQ  L  K    CG +++  +W++TAAHC++   +  V  G+HN+
Sbjct: 20  TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKP--RYIVHLGQHNL 77

Query: 285 EETEHTEQKRNVIRIIPHHNYNAAINKYNH--DIALLELDEPLVLNSYVTPICIADKEYT 342
           ++ E  EQ R      PH  +N ++   +H  DI L+++  P+ +   V P+ ++ +  T
Sbjct: 78  QKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVT 137

Query: 343 NIFLKFGSGYVSGWGRVFH-KGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHE 401
                  S  +SGWG     + R    L+   + +++   C  +    I + M CA   E
Sbjct: 138 ----AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQE 193

Query: 402 GGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEE-CAMKGKYGIYTKVSRYVNWIKEKTK 459
           GG+DSCQGDSGGP V        L GIISWG++ CA+  K G+YTKV +YV+WI+E  K
Sbjct: 194 GGKDSCQGDSGGPLVC----NQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMK 248


>gi|21618357 kallikrein 11 isoform 2 precursor [Homo sapiens]
          Length = 282

 Score =  150 bits (379), Expect = 2e-36
 Identities = 84/239 (35%), Positives = 130/239 (54%), Gaps = 14/239 (5%)

Query: 225 TRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNI 284
           TR++ G + KP   PWQ  L  K    CG +++  +W++TAAHC++   +  V  G+HN+
Sbjct: 52  TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKP--RYIVHLGQHNL 109

Query: 285 EETEHTEQKRNVIRIIPHHNYNAAINKYNH--DIALLELDEPLVLNSYVTPICIADKEYT 342
           ++ E  EQ R      PH  +N ++   +H  DI L+++  P+ +   V P+ ++ +  T
Sbjct: 110 QKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVT 169

Query: 343 NIFLKFGSGYVSGWGRVFH-KGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHE 401
                  S  +SGWG     + R    L+   + +++   C  +    I + M CA   E
Sbjct: 170 ----AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQE 225

Query: 402 GGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEE-CAMKGKYGIYTKVSRYVNWIKEKTK 459
           GG+DSCQGDSGGP V        L GIISWG++ CA+  K G+YTKV +YV+WI+E  K
Sbjct: 226 GGKDSCQGDSGGPLVC----NQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMK 280


>gi|5803199 kallikrein 11 isoform 1 preproprotein [Homo sapiens]
          Length = 250

 Score =  150 bits (379), Expect = 2e-36
 Identities = 84/239 (35%), Positives = 130/239 (54%), Gaps = 14/239 (5%)

Query: 225 TRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNI 284
           TR++ G + KP   PWQ  L  K    CG +++  +W++TAAHC++   +  V  G+HN+
Sbjct: 20  TRIIKGFECKPHSQPWQAALFEKTRLLCGATLIAPRWLLTAAHCLKP--RYIVHLGQHNL 77

Query: 285 EETEHTEQKRNVIRIIPHHNYNAAINKYNH--DIALLELDEPLVLNSYVTPICIADKEYT 342
           ++ E  EQ R      PH  +N ++   +H  DI L+++  P+ +   V P+ ++ +  T
Sbjct: 78  QKEEGCEQTRTATESFPHPGFNNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVT 137

Query: 343 NIFLKFGSGYVSGWGRVFH-KGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHE 401
                  S  +SGWG     + R    L+   + +++   C  +    I + M CA   E
Sbjct: 138 ----AGTSCLISGWGSTSSPQLRLPHTLRCANITIIEHQKCENAYPGNITDTMVCASVQE 193

Query: 402 GGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEE-CAMKGKYGIYTKVSRYVNWIKEKTK 459
           GG+DSCQGDSGGP V        L GIISWG++ CA+  K G+YTKV +YV+WI+E  K
Sbjct: 194 GGKDSCQGDSGGPLVC----NQSLQGIISWGQDPCAITRKPGVYTKVCKYVDWIQETMK 248


>gi|11496281 kallikrein 13 precursor [Homo sapiens]
          Length = 277

 Score =  149 bits (377), Expect = 4e-36
 Identities = 96/257 (37%), Positives = 131/257 (50%), Gaps = 20/257 (7%)

Query: 204 STEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIV 263
           S E+  +L+  T  T  F     + GG    P   PWQ  L  +    CGG +V+ KW++
Sbjct: 20  SQESSKVLN--TNGTSGF-----LPGGYTCFPHSQPWQAALLVQGRLLCGGVLVHPKWVL 72

Query: 264 TAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYN--HDIALLEL 321
           TAAHC++ G+K  V  G+H +   E  EQ R V+  IPH  Y  +    N  HDI LLEL
Sbjct: 73  TAAHCLKEGLK--VYLGKHALGRVEAGEQVREVVHSIPHPEYRRSPTHLNHDHDIMLLEL 130

Query: 322 DEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFH-KGRSALVLQYLRVPLVDRA 380
             P+ L  Y+  + ++   + N      +  VSGWG     +      LQ   + L    
Sbjct: 131 QSPVQLTGYIQTLPLS---HNNRLTPGTTCRVSGWGTTTSPQVNYPKTLQCANIQLRSDE 187

Query: 381 TCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGE-ECAMKG 439
            C +     I +NM CAG  EGG+DSC+GDSGGP V        L GI+SWG+  C    
Sbjct: 188 ECRQVYPGKITDNMLCAGTKEGGKDSCEGDSGGPLVC----NRTLYGIVSWGDFPCGQPD 243

Query: 440 KYGIYTKVSRYVNWIKE 456
           + G+YT+VSRYV WI+E
Sbjct: 244 RPGVYTRVSRYVLWIRE 260


>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score =  149 bits (375), Expect = 7e-36
 Identities = 86/243 (35%), Positives = 132/243 (54%), Gaps = 19/243 (7%)

Query: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCV----ETGVKITVVAGE 281
           R+ GG+ AKPG FPWQV++ G   A   G+++ + W++TAAH V         + +  G 
Sbjct: 444 RIYGGQKAKPGDFPWQVLILGGTTA--AGALLYDNWVLTAAHAVYEQKHDASALDIRMGT 501

Query: 282 HNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEY 341
                  +T+     + I   + ++A    +++DIAL++L+  +V+NS +TPIC+  KE 
Sbjct: 502 LKRLSPHYTQAWSEAVFIHEGYTHDAG---FDNDIALIKLNNKVVINSNITPICLPRKEA 558

Query: 342 TNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRS------TKFTIYNNMF 395
            +       G  SGWG +  +G  A  L Y+ +P+VD   C  +       + ++  NM 
Sbjct: 559 ESFMRTDDIGTASGWG-LTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANML 617

Query: 396 CAGFHEGGRDSCQGDSGGPHVTEVEGTS--FLTGIISWGE-ECAMKGKYGIYTKVSRYVN 452
           CAG   GG+DSC+GDSGG  V     T   F+ GI+SWG   C   G+YG+YTKV  Y+ 
Sbjct: 618 CAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIP 677

Query: 453 WIK 455
           WI+
Sbjct: 678 WIE 680



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 31/112 (27%), Positives = 44/112 (39%), Gaps = 24/112 (21%)

Query: 120 PF-GFEGKNCELDVT-CNIKNGR---CEQFCKNSADNKVVCSCTEGYRLAENQKSC---- 170
           PF GFE      D+  C +  G    C+  C N       CSC  GY L  N+++C    
Sbjct: 126 PFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGG-FYCSCRAGYVLHRNKRTCSALC 184

Query: 171 -------------EPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAET 209
                         P  P P  ++S S T  ++  E     +D+V S + ET
Sbjct: 185 SGQVFTQRSGELSSPEYPRPYPKLS-SCTYSISLEEGFSVILDFVESFDVET 235


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,450,077
Number of Sequences: 37866
Number of extensions: 853769
Number of successful extensions: 4211
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 153
Number of HSP's that attempted gapping in prelim test: 1972
Number of HSP's gapped (non-prelim): 1409
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.