Search of human proteins with 4503231

Search of human proteins with 4503231

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide
5 [Homo sapiens]
         (502 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...  1006   0.0  
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   867   0.0  
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   843   0.0  
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   780   0.0  
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   776   0.0  
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   653   0.0  
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   314   1e-85
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   314   1e-85
gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II [...   246   5e-65
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   170   2e-42
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        157   3e-38
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   155   6e-38
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   152   7e-37
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   151   1e-36
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ...   145   6e-35
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...   144   1e-34
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   144   1e-34
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   144   1e-34
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   144   1e-34
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   144   2e-34
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   142   5e-34
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  142   9e-34
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   140   3e-33
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   139   5e-33
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   139   6e-33
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   139   6e-33
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...   130   2e-30
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   128   1e-29
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   126   5e-29
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   125   1e-28

>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 1006 bits (2602), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
Sbjct: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
Sbjct: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
Sbjct: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
Sbjct: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
Sbjct: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420

Query: 421 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG 480
           KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
Sbjct: 421 KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG 480

Query: 481 LLQPEKPIVLKVDSRDGTLSGE 502
           LLQPEKPIVLKVDSRDGTLSGE
Sbjct: 481 LLQPEKPIVLKVDSRDGTLSGE 502


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  867 bits (2241), Expect = 0.0
 Identities = 423/502 (84%), Positives = 462/502 (92%), Gaps = 1/502 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           M LIP+LA+ETWLLLAVSLVLLYLYGT +HGLFK+LGIPGPTPLP LGN+LSY +G   F
Sbjct: 1   MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           D EC+KKYGK+WG Y+GQ PVLAITDPD+I+TVLVKECYSVFTNRR  GPVGFMKSAIS+
Sbjct: 61  DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKR+RSLLSPTFTSGKLKEM PIIAQYGDVLVRNLRREAE GKPVTLKD+FGAYS
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVIT TSFGVNIDSLNNPQDPFVE+TKK L+F FLDP FLSI +FPFL P+ E LN+ +
Sbjct: 181 MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FP++  NFL KSV RMK+SRL D QKHR+DFLQLMIDSQNSKETESHKALSDLEL AQSI
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           IFIFAGYETTSSVLSF +YELATHPDVQQKLQ+EIDAVLPNKAPPTYD V+QMEYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           NETLRLFP+A+RLER CKKDVEING+FIPKG +V+IP+YALH DPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS 420

Query: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479
           KK KD+IDPYIYTPFG+GPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG 480

Query: 480 GLLQPEKPIVLKVDSRDGTLSG 501
           GLLQPEKP+VLKV+SRDGT+SG
Sbjct: 481 GLLQPEKPVVLKVESRDGTVSG 502


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  843 bits (2179), Expect = 0.0
 Identities = 411/502 (81%), Positives = 458/502 (91%), Gaps = 1/502 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           MDLIPNLAVETWLLLAVSL+LLYLYGTRTHGLFK+LGIPGPTPLP LGN LS+R+G W F
Sbjct: 1   MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPLPFLGNALSFRKGYWTF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           D ECYKKY K+WG Y+ Q P+LAITDPD+I+TVLVKECYSVFTNRR  GPVGFMK+AIS+
Sbjct: 61  DMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISI 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKRIRSLLSPTFTSGKLKEM PIIAQYGDVLVRNLRREAE GKPVTLK +FGAYS
Sbjct: 121 AEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYS 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVIT TSFGV+IDSLNNPQDPFVE+TKK L+F  LDP  LSI +FPFLTP+ EALN+++
Sbjct: 181 MDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPILEALNITV 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FP+  I+FL+KSV ++K+ RL + QKHR+DFLQLMIDSQNSK++E+HKALSDLEL AQSI
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           IFIFAGYETTSSVLSF +YELATHPDVQQK+QKEID VLPNKAPPTYD V+Q+EYLDMVV
Sbjct: 301 IFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           NETLRLFPVA+RLER CKKDVEING+FIPKG +V+IP+Y LHHDPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFS 420

Query: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479
           KK KD+IDPYIYTPFG+GPRNCIGMRFAL+NMKLAL+RVLQNFSFKPCKETQIPLKL   
Sbjct: 421 KKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFG 480

Query: 480 GLLQPEKPIVLKVDSRDGTLSG 501
           GLL  EKPIVLK +SRD T+SG
Sbjct: 481 GLLLTEKPIVLKAESRDETVSG 502


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  780 bits (2015), Expect = 0.0
 Identities = 380/502 (75%), Positives = 427/502 (85%), Gaps = 1/502 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           MDLIPN A+ETW+L+A SLVLLY+YGT +H LFK+LGIPGPTPLP LG +L Y +GLW F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           D EC +KYG+MWG YEGQ P+L I DPD+I+TVLVKECYSVFTN+  LGP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEM PII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVITGT FGVN+DSLNNPQDPF+++ KK LK  FLDP  L I LFPFLTPVFEALN+ L
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FPKD  +FL  S+ RMK+SRL DKQKHR+DF Q MIDSQNSKET+SHKALSDLEL AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           I IFA Y+TTS+ L F +YELATHPDVQQKLQ+EIDAVLPNKAP TYDA+VQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           NETLRLFPV  R+ R CKKD+EINGVFIPKG  V++P YALHHDPKYWTEPE+F PERFS
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPERFS 420

Query: 421 KK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQ 479
           KK KDSID Y Y PFG GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKLD  
Sbjct: 421 KKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDNL 480

Query: 480 GLLQPEKPIVLKVDSRDGTLSG 501
            +LQPEKPIVLKV  RDG  SG
Sbjct: 481 PILQPEKPIVLKVHLRDGITSG 502


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  776 bits (2003), Expect = 0.0
 Identities = 380/503 (75%), Positives = 427/503 (84%), Gaps = 2/503 (0%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           MDLIPN A+ETW+L+A SLVLLY+YGT +H LFK+LGIPGPTPLP LG +L Y +GLW F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           D EC +KYG+MWG YEGQ P+L I DPD+I+TVLVKECYSVFTN+  LGP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEM PII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVITGT FGVN+DSLNNPQDPF+++ KK LK  FLDP  L I LFPFLTPVFEALN+ L
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FPKD  +FL  S+ RMK+SRL DKQKHR+DF Q MIDSQNSKET+SHKALSDLEL AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           I IFA Y+TTS+ L F +YELATHPDVQQKLQ+EIDAVLPNKAP TYDA+VQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPE-RF 419
           NETLRLFPV  R+ R CKKD+EINGVFIPKG  V++P YALHHDPKYWTEPE+F PE RF
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPESRF 420

Query: 420 SKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDT 478
           SKK KDSID Y Y PFG GPRNCIGMRFAL N+KLA+IR LQNFSFKPCKETQIPLKLD 
Sbjct: 421 SKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLKLDN 480

Query: 479 QGLLQPEKPIVLKVDSRDGTLSG 501
             +LQPEKPIVLKV  RDG  SG
Sbjct: 481 LPILQPEKPIVLKVHLRDGITSG 503


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  653 bits (1684), Expect = 0.0
 Identities = 313/418 (74%), Positives = 357/418 (85%)

Query: 1   MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 60
           MDLIPN A+ETW+L+A SLVLLY+YGT +H LFK+LGIPGPTPLP LG +L Y +GLW F
Sbjct: 1   MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPLPFLGTILFYLRGLWNF 60

Query: 61  DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL 120
           D EC +KYG+MWG YEGQ P+L I DPD+I+TVLVKECYSVFTN+  LGP+GF+KSA+S 
Sbjct: 61  DRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQMPLGPMGFLKSALSF 120

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS 180
           AEDEEWKRIR+LLSP FTS K KEM PII+Q GD+LVR+LR+EAE  K + LKD FGAY+
Sbjct: 121 AEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYT 180

Query: 181 MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL 240
           MDVITGT FGVN+DSLNNPQDPF+++ KK LK  FLDP  L I LFPFLTPVFEALN+ L
Sbjct: 181 MDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFLTPVFEALNIGL 240

Query: 241 FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI 300
           FPKD  +FL  S+ RMK+SRL DKQKHR+DF Q MIDSQNSKET+SHKALSDLEL AQSI
Sbjct: 241 FPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSI 300

Query: 301 IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV 360
           I IFA Y+TTS+ L F +YELATHPDVQQKLQ+EIDAVLPNKAP TYDA+VQMEYLDMVV
Sbjct: 301 IIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNKAPVTYDALVQMEYLDMVV 360

Query: 361 NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
           NETLRLFPV  R+ R CKKD+EINGVFIPKG  V++P YALHHDPKYWTEPE+F PER
Sbjct: 361 NETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPER 418


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  314 bits (804), Expect = 1e-85
 Identities = 181/522 (34%), Positives = 288/522 (55%), Gaps = 42/522 (8%)

Query: 11  TWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK 70
           T  L    L LL  Y T      ++LG+  P P P +GN+  +RQG W+   E  K YG 
Sbjct: 18  TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGP 77

Query: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRI 129
           + G Y G+   + I++PD+I+ VLV E +S FTNR + G     +  ++    D+ W+ +
Sbjct: 78  LCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEV 136

Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189
           R  L   F+  KL EM P+I+Q  D+L+ +L+R AE G    ++  +  Y+ DV+   +F
Sbjct: 137 RGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 196

Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP-FLTPVFEALNVSLFPKDTIN- 247
           G  +DS   P+DPFV+  K+F +F    P+ + ++ FP  + P+   L      +D +N 
Sbjct: 197 GTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNK--NRDELNG 254

Query: 248 FLSKSVNRMKKSRLNDKQ---KHRLDFLQLMIDSQNSKE--------------------- 283
           F +K +  +    L D+Q   + R DFLQ+++D+++S                       
Sbjct: 255 FFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKP 312

Query: 284 --TESH------KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335
             +  H      + L+  E+  Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL +E+
Sbjct: 313 NPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV 372

Query: 336 DAVLPNKAPPTYDAVVQ-MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394
           D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP G+++
Sbjct: 373 DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVL 432

Query: 395 VIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453
            +   ALHHDP++W  PE F PERF+ + +    P+ Y PFG GPR+C+G+R  L+ +KL
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
            L+ VL  F F+ C ETQ+PL+L+++  L P+  + +K+ SR
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  314 bits (804), Expect = 1e-85
 Identities = 181/522 (34%), Positives = 288/522 (55%), Gaps = 42/522 (8%)

Query: 11  TWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK 70
           T  L    L LL  Y T      ++LG+  P P P +GN+  +RQG W+   E  K YG 
Sbjct: 18  TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGP 77

Query: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRI 129
           + G Y G+   + I++PD+I+ VLV E +S FTNR + G     +  ++    D+ W+ +
Sbjct: 78  LCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEV 136

Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189
           R  L   F+  KL EM P+I+Q  D+L+ +L+R AE G    ++  +  Y+ DV+   +F
Sbjct: 137 RGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 196

Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP-FLTPVFEALNVSLFPKDTIN- 247
           G  +DS   P+DPFV+  K+F +F    P+ + ++ FP  + P+   L      +D +N 
Sbjct: 197 GTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNK--NRDELNG 254

Query: 248 FLSKSVNRMKKSRLNDKQ---KHRLDFLQLMIDSQNSKE--------------------- 283
           F +K +  +    L D+Q   + R DFLQ+++D+++S                       
Sbjct: 255 FFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKP 312

Query: 284 --TESH------KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335
             +  H      + L+  E+  Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL +E+
Sbjct: 313 NPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV 372

Query: 336 DAVLPNKAPPTYDAVVQ-MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394
           D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP G+++
Sbjct: 373 DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVL 432

Query: 395 VIPTYALHHDPKYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKL 453
            +   ALHHDP++W  PE F PERF+ + +    P+ Y PFG GPR+C+G+R  L+ +KL
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKL 492

Query: 454 ALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
            L+ VL  F F+ C ETQ+PL+L+++  L P+  + +K+ SR
Sbjct: 493 TLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIKIVSR 534


>gi|195972900 thromboxane A synthase 1, platelet isoform TXS-II
           [Homo sapiens]
          Length = 460

 Score =  246 bits (627), Expect = 5e-65
 Identities = 148/445 (33%), Positives = 237/445 (53%), Gaps = 41/445 (9%)

Query: 11  TWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGK 70
           T  L    L LL  Y T      ++LG+  P P P +GN+  +RQG W+   E  K YG 
Sbjct: 18  TVALSVALLALLKWYSTSAFSRLEKLGLRHPKPSPFIGNLTFFRQGFWESQMELRKLYGP 77

Query: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLG-PVGFMKSAISLAEDEEWKRI 129
           + G Y G+   + I++PD+I+ VLV E +S FTNR + G     +  ++    D+ W+ +
Sbjct: 78  LCGYYLGRRMFIVISEPDMIKQVLV-ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEV 136

Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189
           R  L   F+  KL EM P+I+Q  D+L+ +L+R AE G    ++  +  Y+ DV+   +F
Sbjct: 137 RGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVAF 196

Query: 190 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFP-FLTPVFEALNVSLFPKDTIN- 247
           G  +DS   P+DPFV+  K+F +F    P+ + ++ FP  + P+   L      +D +N 
Sbjct: 197 GTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMVPLARILPNK--NRDELNG 254

Query: 248 FLSKSVNRMKKSRLNDKQ---KHRLDFLQLMIDSQNS----------------------- 281
           F +K +  +    L D+Q   + R DFLQ+++D+++S                       
Sbjct: 255 FFNKLIRNV--IALRDQQAAEERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKP 312

Query: 282 ------KETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI 335
                 + +   + L+  E+  Q+ IF+ AGYE  ++ LSF  Y LAT+PD Q+KL +E+
Sbjct: 313 NPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREV 372

Query: 336 DAVLPNKAPPTYDAVVQ-MEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMV 394
           D        P + ++ + + YLDMV+ ETLR++P A R  R   +D E+ G  IP G+++
Sbjct: 373 DVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVL 432

Query: 395 VIPTYALHHDPKYWTEPEEFRPERF 419
            +   ALHHDP++W  PE F PER+
Sbjct: 433 EMAVGALHHDPEHWPSPETFNPERY 457


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  170 bits (431), Expect = 2e-42
 Identities = 138/521 (26%), Positives = 254/521 (48%), Gaps = 61/521 (11%)

Query: 14  LLAVSLVLLYLYGTRTHGLFKRLGIPGPT---PLPLLGNVLSYRQGLWKFD------TEC 64
           L   SLVL  L    ++    +   P PT     PL+G+ L  +    +F       TE 
Sbjct: 24  LAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEE 83

Query: 65  YKKYG--KMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL-- 120
           Y+     K+W    G +P++A+ + + +  +L     S   ++ S+    F++  + L  
Sbjct: 84  YRHMPLLKLW---VGPVPMVALYNAENVEVILTS---SKQIDKSSM--YKFLEPWLGLGL 135

Query: 121 --AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGA 178
             +   +W+  R +L+PTF    L++   I+ +  ++LV+ L +   +       + F  
Sbjct: 136 LTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-------EAFNC 188

Query: 179 Y------SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGF----LDPLFLSIILFPF 228
           +      ++D+I  T+ G NI + +N    +V +  +  +  F    +  L+L +    F
Sbjct: 189 FFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMF 248

Query: 229 LTPVFEALNVSLFPKDTINFLSKSVNRMKKSR-----------LNDKQKHRLDFLQLMID 277
                   ++ +    T + +++  N M  +              +K++  LD L  + D
Sbjct: 249 KEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308

Query: 278 SQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDA 337
            + ++       LS  ++  +   F+F G++TT++ ++++LY L ++P+VQ+K+  E+D 
Sbjct: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361

Query: 338 VL-PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVI 396
           V   +  P T + + ++ YL+ V+ ETLRLFP      R+  +D E+ G  + KG+  VI
Sbjct: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421

Query: 397 PTYALHHDPKYWTEPEEFRPER-FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455
             YALH DP+Y+  PEEF+PER F +      PY Y PF  GPRNCIG +FA+M  K  L
Sbjct: 422 IPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTIL 481

Query: 456 IRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496
             +L++F  +  ++ +  L L+ Q +L+P   I +K+  R+
Sbjct: 482 SCILRHFWIESNQKRE-ELGLEGQLILRPSNGIWIKLKRRN 521


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  157 bits (396), Expect = 3e-38
 Identities = 119/447 (26%), Positives = 212/447 (47%), Gaps = 40/447 (8%)

Query: 65  YKKYGKMWGTYEGQLPV--------LAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS 116
           ++ Y K+   Y   +P+         ++ DPD  + +L ++      + + L    ++  
Sbjct: 66  FEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILE--SWVGR 123

Query: 117 AISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIF 176
            +   +  +WK+ R ++ P F    LK    ++++   +++        +   + L    
Sbjct: 124 GLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHV 183

Query: 177 GAYSMDVITGTSFG----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPV 232
              ++D I   +F     + +DS  +     V +  K       + L  + ++F F +  
Sbjct: 184 SLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFSS-- 241

Query: 233 FEALNVSLFPKDTINFLSKSVNRMKKSRLNDK------QKHRLDFLQLMIDSQNSKETES 286
            +    S F ++   F  K +   K+S L DK      QK R DFL +++    S ++E+
Sbjct: 242 -QGQIFSKFNQELHQFTEKVIQDRKES-LKDKLKQDTTQKRRWDFLDILL----SAKSEN 295

Query: 287 HKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT 346
            K  S+ +L A+   F+FAG++TTSS +S+ LY LA +P+ QQ+ + EI  +L + +  T
Sbjct: 296 TKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSIT 355

Query: 347 YDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDP 405
           ++ + QM Y  M + E LRL+   + + R   K +   +G  +P G  V I  +ALHH+P
Sbjct: 356 WEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNP 415

Query: 406 KYWTEPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSF 464
            +W +P+ F P RFS++  + I PY + PF  G RNCIG  FA++  K+A+   L  F  
Sbjct: 416 YFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKL 475

Query: 465 KPCKETQIPLKLDTQGLLQPEKPIVLK 491
            P          D     QP + +VLK
Sbjct: 476 AP----------DHSRPPQPVRQVVLK 492


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  155 bits (393), Expect = 6e-38
 Identities = 135/502 (26%), Positives = 238/502 (47%), Gaps = 64/502 (12%)

Query: 7   LAVETWLLLAV-------SLVLLYLYGTRTHGLFKRLGIPGPTP----LPLLGNVLSYRQ 55
           +A   WLLL V       + +L + Y    +G   R   P P      L  LG V    +
Sbjct: 14  VAASPWLLLLVVGASWLLARILAWTYAFYHNGRRLRC-FPQPRKQNWFLGHLGLVTPTEE 72

Query: 56  GLWKFDTECYKKYGKMWGTYEGQL-PVLAITDPDVIRTVLVKECYSVFTNR-----RSLG 109
           GL +  T+    Y + +  + G + P++ +  PD++R+V+        T++     ++L 
Sbjct: 73  GL-RVLTQLVATYPQGFVRWLGPITPIINLCHPDIVRSVI--NTSDAITDKDIVFYKTLK 129

Query: 110 PVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP 169
           P  ++   + L+  ++W+  R LL+P F    LK    I ++  +++    +R A +G  
Sbjct: 130 P--WLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKWQRLAMEGS- 186

Query: 170 VTLKDIFGAYSM---DVITGTSFGVNIDSLNNPQD---PFVESTKKFLK-----FGFLDP 218
            T  D+F   S+   D +    F  + +    P +     +E +   +K     F + D 
Sbjct: 187 -TCLDVFEHISLMTLDSLQKCIFSFDSNCQEKPSEYITAIMELSALVVKRNNQFFRYKDF 245

Query: 219 LFLSIILFPFLTP----------VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHR 268
           L+       FLTP          +      ++  +      S+ V+   +++   K    
Sbjct: 246 LY-------FLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGVDDFLQAKAKSKT--- 295

Query: 269 LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQ 328
           LDF+ +++ S    E ++ K LSD ++ A++  F+F G++TT+S LS+ LY LA HP+ Q
Sbjct: 296 LDFIDVLLLS----EDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQ 351

Query: 329 QKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NG 385
           ++ ++E+  +L ++ P    +D + Q+ +L M + E+LRL P      R C +DV + + 
Sbjct: 352 ERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDS 411

Query: 386 VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGPRNCIGM 444
             IPKG++  I  +A+HH+P  W +PE + P RF  +      P  + PF  GPRNCIG 
Sbjct: 412 RVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQ 471

Query: 445 RFALMNMKLALIRVLQNFSFKP 466
           +FA+  MK+ L   L  F   P
Sbjct: 472 KFAMAEMKVVLALTLLRFRILP 493


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  152 bits (384), Expect = 7e-37
 Identities = 117/442 (26%), Positives = 220/442 (49%), Gaps = 25/442 (5%)

Query: 63  ECYKKYGKMWGTYEGQLPVL-AITDPDVIRTVLVK-ECYSVFTNRRSLGPVGFMKSAISL 120
           E  +KY + +  + G       I DPD  +T+L + +  S +  + S   +G     ++ 
Sbjct: 71  EIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPPLLG---KGLAA 127

Query: 121 AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAE-KGKPVTLKDIFGAY 179
            +  +W + R LL+P F    LK    ++A    +++    +    +   V + +   + 
Sbjct: 128 LDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSM 187

Query: 180 SMDVITGTSFGVNID-SLNNPQDPFVESTKKFLKFGF---LDPLFLSIILFPFLTPV--- 232
           S+D+I   +F    +   N+  DP+ ++  +  K  F      L+ S I+F  L+P    
Sbjct: 188 SLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK-LSPQGYR 246

Query: 233 FEALN--VSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKAL 290
           F+ L+  ++ +    I    KS+    K     K+K++ DFL +++ +++    ES  + 
Sbjct: 247 FQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQ-DFLDIVLSAKD----ESGSSF 301

Query: 291 SDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAV 350
           SD+++ ++   F+ AG++T ++ +S+ LY LA +P+ Q++ ++E+  +L + +  T+D +
Sbjct: 302 SDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQL 361

Query: 351 VQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWT 409
            +M Y  M + ET RL P    + R   K +   +G  +P G  VV+  + LHH+P  W 
Sbjct: 362 GEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWK 421

Query: 410 EPEEFRPERFSKK-KDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCK 468
            P+ F P RFS++  D   PY Y PF  G RNCIG  FA++ +K+ +  +L +F   P  
Sbjct: 422 NPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTP-- 479

Query: 469 ETQIPLKLDTQGLLQPEKPIVL 490
           +   PL      +L+P+  + L
Sbjct: 480 DPTRPLTFPNHFILKPKNGMYL 501


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  151 bits (382), Expect = 1e-36
 Identities = 122/448 (27%), Positives = 214/448 (47%), Gaps = 46/448 (10%)

Query: 47  LGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQL-PVLAITDPDVIRTVLVKECYSVFTNR 105
           LG +    +GL K  T+    Y + +  + G + P + +  PD IR++          + 
Sbjct: 64  LGLITPTEEGL-KDSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDN 122

Query: 106 ---RSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRR 162
              R L P  ++   I L+  ++W R R +L+P F    LK    I  +  ++++   + 
Sbjct: 123 LFIRFLKP--WLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQH 180

Query: 163 EAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 222
            A +G   +  D+F   S+         + +DSL      F    ++         L LS
Sbjct: 181 LASEGS--SRLDMFEHISL---------MTLDSLQKCIFSFDSHCQERPSEYIATILELS 229

Query: 223 IILFPFLTPVFEALNVSLFPKDT----------INFLSKSVNRMKKSRL---------ND 263
            ++      + + ++   +              ++  + +V R ++  L          D
Sbjct: 230 ALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKD 289

Query: 264 KQKHR-LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELA 322
           K K + LDF+ +++ S++    E  KALSD ++ A++  F+F G++TT+S LS+ LY LA
Sbjct: 290 KAKSKTLDFIDVLLLSKD----EDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLA 345

Query: 323 THPDVQQKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKD 380
            HP+ Q++ ++E+  +L ++ P    +D + Q+ +L M V E+LRL P A  + R C +D
Sbjct: 346 RHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQD 405

Query: 381 VEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS-KKKDSIDPYIYTPFGTGP 438
           + + +G  IPKG   +I    +HH+P  W +PE + P RF  +      P  + PF  GP
Sbjct: 406 IVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGP 465

Query: 439 RNCIGMRFALMNMKLALIRVLQNFSFKP 466
           RNCIG  FA+  MK+ L  +L +F F P
Sbjct: 466 RNCIGQAFAMAEMKVVLALMLLHFRFLP 493


>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 508

 Score =  145 bits (367), Expect = 6e-35
 Identities = 129/480 (26%), Positives = 218/480 (45%), Gaps = 41/480 (8%)

Query: 38  IPGPTPLPLLGNVLSYR--QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLV 95
           IPGP+    L  +        L +   +    +G +W    G +  + +  P ++  +L 
Sbjct: 40  IPGPSTPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLR 99

Query: 96  KE-------CYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFP- 147
           +E        +S +T  R           +  AE EEW+R+RSLL+P     +    +  
Sbjct: 100 QEGPRPERCSFSPWTEHRRCRQ---RACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAG 156

Query: 148 IIAQYGDVLVRNLRREAEKGK--PVTLKDIFGAY---SMDVITGTSFGVNIDSLNNPQDP 202
            +      LVR LRR+  +G   P  ++D+ G +    ++ I     G  +  L     P
Sbjct: 157 TLNNVVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPP 216

Query: 203 FVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLN 262
               T+ F++   +  +F+S +L   +      L    + +     L +  ++M      
Sbjct: 217 ---DTETFIRA--VGSVFVSTLLTMAMPHWLRHLVPGPWGR-----LCRDWDQMFAFAQR 266

Query: 263 DKQKHRLDFLQLMIDSQNSKETESHKALSDL----ELAAQSII-----FIFAGYETTSSV 313
             ++   +   +    Q  K+ ES   L+      EL AQSI+      + AG +T S+ 
Sbjct: 267 HVERREAE-AAMRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNT 325

Query: 314 LSFTLYELATHPDVQQKLQKEIDAVLP--NKAPPTYDAVVQMEYLDMVVNETLRLFPVAI 371
           LS+ LYEL+ HP+VQ  L  EI A L   + A P+   + Q+  L  VV E LRL+PV  
Sbjct: 326 LSWALYELSRHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVP 385

Query: 372 RLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIY 431
              R   KD+ +    IPK ++V +  YA   DP  + EP  FRP R+  +  +  P+  
Sbjct: 386 GNSRVPDKDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFAS 445

Query: 432 TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLK 491
            PFG G R+C+G R A + +++AL ++L +F  +P +    P++  T+ +L PE+ I L+
Sbjct: 446 LPFGFGKRSCMGRRLAELELQMALAQILTHFEVQP-EPGAAPVRPKTRTVLVPERSINLQ 504


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score =  144 bits (364), Expect = 1e-34
 Identities = 130/479 (27%), Positives = 222/479 (46%), Gaps = 57/479 (11%)

Query: 38  IPGPTPLPLLGNVLSYRQGLWK------FDT--ECYKKYGKMWGTYEGQLPVLAITDPDV 89
           +PGPT  PLLG++L   Q LWK       DT  E +KKYGK++    G    + +  P +
Sbjct: 58  LPGPTSWPLLGSLL---QILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCL 114

Query: 90  IRTVLVKECYSVFTNRRSLGPVGFMKS------AISLAEDEEWKRIRSLLSPTFTSGKLK 143
           +  +   E  S +  R  + P    +        + + E E+W+R+RS         K  
Sbjct: 115 LEALYRTE--SAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLM--KPG 170

Query: 144 EMFPIIAQYGDVLVRNLRREAE----KGKPVTLKDIFGAYSMD----VITGTSFGVNIDS 195
           E+  +  +  +VL   + R  E    +G    L      +S +    V+    FG+   +
Sbjct: 171 EVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKN 230

Query: 196 LNNPQDPFVESTKKFLK-FGFLDPLFLSIILFPFLTPV--FEALNVSLFPKDTINF--LS 250
             +    F+ + K  +  FG +            +TPV   ++LN  ++   T+ +  + 
Sbjct: 231 AGDEAVNFIMAIKTMMSTFGRM-----------MVTPVELHKSLNTKVWQDHTLAWDTIF 279

Query: 251 KSVNRMKKSRLND-KQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 309
           KSV     +RL    Q+   DFL  +       + E + A+++L+LAA          ET
Sbjct: 280 KSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAA---------VET 330

Query: 310 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV 369
           T++ L + LY L+ +P VQQKL KEI +VLP    P  + +  M YL   + E++RL P 
Sbjct: 331 TANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPS 390

Query: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429
                RT  K   +    +PKG+++++ T  L      + +  +FRPER+ ++K+ I+P+
Sbjct: 391 VPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPF 450

Query: 430 IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPI 488
            + PFG G R CIG R A + + LAL  +++ +  +       P+++   G L P + +
Sbjct: 451 AHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNE--PVEMLHSGTLVPSREL 507


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  144 bits (364), Expect = 1e-34
 Identities = 108/407 (26%), Positives = 193/407 (47%), Gaps = 30/407 (7%)

Query: 80  PVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK----SAISLAEDEEWKRIRSLLSP 135
           P+L +  PD+IR +      S     + +   GF+K      + L+  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSA---SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNID 194
            F    LK    I  +  +++    +R A +G   + + +     ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQD---------PFVESTKK--FLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK 243
               P +          FVE   +   L   FL  L      F     +      ++  +
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273

Query: 244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303
                 ++ ++   K++   K    LDF+ +++ S++    E  K LSD ++ A++  F+
Sbjct: 274 RRCTLPTQGIDDFLKNKAKSKT---LDFIDVLLLSKD----EDGKELSDEDIRAEADTFM 326

Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP--PTYDAVVQMEYLDMVVN 361
           F G++TT+S LS+ LY LA HP+ Q++ ++E+  +L ++ P    +D + Q+ +L M + 
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIK 386

Query: 362 ETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           E+LRL P    + R C +D  + +G  IPKG + +I    +H++P  W +PE + P RF 
Sbjct: 387 ESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFD 446

Query: 421 KKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
           ++      P  + PF  GPRNCIG  FA+  MK+ L   L +F   P
Sbjct: 447 QENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  144 bits (364), Expect = 1e-34
 Identities = 108/407 (26%), Positives = 193/407 (47%), Gaps = 30/407 (7%)

Query: 80  PVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMK----SAISLAEDEEWKRIRSLLSP 135
           P+L +  PD+IR +      S     + +   GF+K      + L+  ++W R R +L+P
Sbjct: 97  PLLILCHPDIIRPITSA---SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTP 153

Query: 136 TFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNID 194
            F    LK    I  +  +++    +R A +G   + + +     ++D +    F    +
Sbjct: 154 AFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESN 213

Query: 195 SLNNPQD---------PFVESTKK--FLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPK 243
               P +          FVE   +   L   FL  L      F     +      ++  +
Sbjct: 214 CQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQE 273

Query: 244 DTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303
                 ++ ++   K++   K    LDF+ +++ S++    E  K LSD ++ A++  F+
Sbjct: 274 RRCTLPTQGIDDFLKNKAKSKT---LDFIDVLLLSKD----EDGKELSDEDIRAEADTFM 326

Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAP--PTYDAVVQMEYLDMVVN 361
           F G++TT+S LS+ LY LA HP+ Q++ ++E+  +L ++ P    +D + Q+ +L M + 
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIK 386

Query: 362 ETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           E+LRL P    + R C +D  + +G  IPKG + +I    +H++P  W +PE + P RF 
Sbjct: 387 ESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFD 446

Query: 421 KKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
           ++      P  + PF  GPRNCIG  FA+  MK+ L   L +F   P
Sbjct: 447 QENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILP 493


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  144 bits (364), Expect = 1e-34
 Identities = 117/438 (26%), Positives = 210/438 (47%), Gaps = 39/438 (8%)

Query: 79  LPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-----VGFMK----SAISLAEDEEWKRI 129
           LP+L +  PD I+ +L            ++ P      GF+K      + L++ ++W R 
Sbjct: 104 LPLLVLVHPDYIKPLLGASA--------AIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRH 155

Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM---DVITG 186
           R LL+P F    LK    I  Q  D++    R  AE G  V+L D+F   S+   D +  
Sbjct: 156 RRLLTPAFHFDILKPYMKIFNQSADIMHAKWRHLAE-GSAVSL-DMFEHISLMTLDSLQK 213

Query: 187 TSFGVNIDSLNNPQD---PFVESTKKFLKFGFLDPLFLSIILFPFLTP--VFEALN-VSL 240
             F  N +      D     +E +   ++  +    +L  I +         +A + V  
Sbjct: 214 CVFSYNSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHH 273

Query: 241 FPKDTINFLSKSVNRM-KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299
           F  + I    +++ +   ++ L  KQ   LDF+ +++ +++    E  K LSD ++ A++
Sbjct: 274 FTTEVIQERRRALRQQGAEAWLKAKQGKTLDFIDVLLLARD----EDGKELSDEDIRAEA 329

Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK--APPTYDAVVQMEYLD 357
             F+F G++TTSS +S+ L+ LA +P+ Q+K ++EI  V+  +      +D + Q+ +  
Sbjct: 330 DTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTT 389

Query: 358 MVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRP 416
           M + E+LR +P    + R C +D+++ +G  IPKG + ++  Y  HH+P  W + + + P
Sbjct: 390 MCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNP 449

Query: 417 ERFS-KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475
            RF         P  Y PF  GPRNCIG  FA+  +++ +   L  F     +  ++  K
Sbjct: 450 YRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRK 509

Query: 476 LDTQGLLQPEKPIVLKVD 493
            +   +L+ E  + LKV+
Sbjct: 510 PEL--ILRTENGLWLKVE 525


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  144 bits (362), Expect = 2e-34
 Identities = 128/478 (26%), Positives = 220/478 (46%), Gaps = 28/478 (5%)

Query: 13  LLLAVSLVLLYLYGTRTHGLFKRLG-IPGPTPLPLLGNV--LSYRQGLWKFD--TECYKK 67
           LLL +  V LYL+      L K L   P P    L G++  L   Q L +     E +  
Sbjct: 28  LLLLIKAVQLYLH---RQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPS 84

Query: 68  YGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-VGFMKSAISLAEDEEW 126
               W  + G++ V  + DPD ++ +L +       + R L P +G+    + L   + W
Sbjct: 85  ACPHW-LWGGKVRV-QLYDPDYMKVILGRSDPKSHGSYRFLAPWIGY---GLLLLNGQTW 139

Query: 127 KRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
            + R +L+P F    LK    ++A    V++        +  P+ +       ++D I  
Sbjct: 140 FQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMK 199

Query: 187 TSFG----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP---VFEALNVS 239
            +F     + +D  +      +      +     +    +  ++   +       A  ++
Sbjct: 200 CAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLA 259

Query: 240 LFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQS 299
               D +  L K+  + +      K+K  LDFL +++ ++     E+   LSD +L A+ 
Sbjct: 260 HQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEV 315

Query: 300 IIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMV 359
             F+F G++TT+S +S+ LY LATHP  Q++ ++EI ++L + A  T++ + QM Y  M 
Sbjct: 316 DTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMC 375

Query: 360 VNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
           + E LRL+P    + R     V   +G  +PKG MV++  Y LHH+PK W  PE F P R
Sbjct: 376 IKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFR 435

Query: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
           F+    +   + + PF  G RNCIG +FA+  +K+A    L  F   P   T+IP+ +
Sbjct: 436 FA-PGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP-DPTRIPIPI 491


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  142 bits (359), Expect = 5e-34
 Identities = 104/371 (28%), Positives = 178/371 (47%), Gaps = 25/371 (6%)

Query: 113 FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP-VT 171
           ++   + L+  E+W R R +L+P F    LK    I  +  +++    +  A +G   + 
Sbjct: 131 WLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLD 190

Query: 172 LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFL-----DPLFLSIILF 226
           + +     ++D +    F  +      P     E     L+   L       + L I   
Sbjct: 191 MFEHISLMTLDSLQKCVFSFDSHCQEKPS----EYIAAILELSALVTKRHQQILLYIDFL 246

Query: 227 PFLTPVFEALNVSL-FPKDTINFLSKSVNRMKKSR-----LNDKQKHR-LDFLQLMIDSQ 279
            +LTP  +    +     D  + + +   R   S+     L  K K + LDF+ +++ S+
Sbjct: 247 YYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSK 306

Query: 280 NSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL 339
           +    E  K LSD ++ A++  F+F G++TT+S LS+ LY LA HP+ Q++ ++E+  +L
Sbjct: 307 D----EDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL 362

Query: 340 PNKAPP--TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVI 396
            ++ P    +D + Q+ +L M + E+LRL P    + R C +D+ + +G  IPKG + +I
Sbjct: 363 KDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLI 422

Query: 397 PTYALHHDPKYWTEPEEFRPERFSKKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLAL 455
             +  HH+P  W +PE + P RF  K      P  + PF  GPRNCIG  FA+  MK+ L
Sbjct: 423 SVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVL 482

Query: 456 IRVLQNFSFKP 466
              L  F   P
Sbjct: 483 GLTLLRFRVLP 493


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  142 bits (357), Expect = 9e-34
 Identities = 128/500 (25%), Positives = 231/500 (46%), Gaps = 39/500 (7%)

Query: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPT-PLPLLGNVLSYRQGLWKFDT--------- 62
           +LLA  L   +++  R+    +   IPGP  P  LLG++  +    WK D          
Sbjct: 12  VLLAFGLCCTFVHRARS----RYEHIPGPPRPSFLLGHLPCF----WKKDEVGGRVLQDV 63

Query: 63  --ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-RSLGPVG----FMK 115
             +  KKYG +          + +T P+ ++  L+   Y+  +   R+L  V     F +
Sbjct: 64  FLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQ 123

Query: 116 SAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDI 175
             +S    E W + R ++   F+   L  +     +  + LV  L  +A+   PV+++D+
Sbjct: 124 GLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDM 183

Query: 176 FGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEA 235
               +MD++   +FG+    L   Q P  ++ K  L+        L+  L      + E 
Sbjct: 184 LTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREV 243

Query: 236 LNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLEL 295
                  +++I FL + V R    R  +  K R + +   I +Q  K  E   A  D  L
Sbjct: 244 -------RESIRFL-RQVGRDWVQRRREALK-RGEEVPADILTQILKAEEG--AQDDEGL 292

Query: 296 AAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEY 355
               + F  AG+ET+++ L+FT+ EL+  P++  +LQ E+D V+ +K    ++ + +++Y
Sbjct: 293 LDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQY 352

Query: 356 LDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFR 415
           L  V+ E+LRL+P A    R  +++  I+GV +P  + ++  TY +     Y+ +P  F 
Sbjct: 353 LSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFN 412

Query: 416 PERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLK 475
           P+RF         + Y PF  G R+CIG +FA M +K+ + ++LQ   F+     +  L+
Sbjct: 413 PDRFGPGAPK-PRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQ 471

Query: 476 LDTQGLLQPEKPIVLKVDSR 495
              Q  L+P  P++  +  R
Sbjct: 472 --EQATLKPLDPVLCTLRPR 489


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  140 bits (353), Expect = 3e-33
 Identities = 100/369 (27%), Positives = 183/369 (49%), Gaps = 24/369 (6%)

Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181
           E  +W + R LL+P F    LK    +  +   +++     +A +GK   +    G  ++
Sbjct: 130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMAL 189

Query: 182 DVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS-IILFPF-------LTP-- 231
           + +   +FG     L + +D     +  +L    L  L    ++ F +       LTP  
Sbjct: 190 NTLMKCTFGRGDTGLGHSRD-----SSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHG 244

Query: 232 --VFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKA 289
                A  V+    D +    K+  + +K R   + +  LDFL +++ +++  + +    
Sbjct: 245 RRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK---- 300

Query: 290 LSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDA 349
           LSD +L A+   F+F G++TT+S +S+ LY +A +P+ Q + ++E+  +L ++    +D 
Sbjct: 301 LSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDD 360

Query: 350 VVQMEYLDMVVNETLRLFPVAIRLERTCKKDVE-INGVFIPKGSMVVIPTYALHHDPKYW 408
           + +M YL M + E+ RL+P   ++ R   K V  ++G  +P GS++ +  YALH +   W
Sbjct: 361 LGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVW 420

Query: 409 TEPEEFRPERFSKKKDS-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPC 467
            +PE F   RFS +  S   P+ + PF  GPRNCIG +FA+  MK+     L  F F   
Sbjct: 421 PDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-L 479

Query: 468 KETQIPLKL 476
             +++P+K+
Sbjct: 480 DPSRLPIKM 488


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  139 bits (351), Expect = 5e-33
 Identities = 109/415 (26%), Positives = 197/415 (47%), Gaps = 22/415 (5%)

Query: 71  MWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGP-VGFMKSAISLAEDEEWKRI 129
           +WG   G++ V  + DPD ++ +L +       + + L P +G+    + L   + W + 
Sbjct: 90  IWG---GKVRV-QLYDPDYMKVILGRSDPKSHGSYKFLAPRIGY---GLLLLNGQTWFQH 142

Query: 130 RSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSF 189
           R +L+P F +  LK    ++A    V++        +  P+ +       ++D I  ++F
Sbjct: 143 RRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAF 202

Query: 190 G----VNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTP---VFEALNVSLFP 242
                + +D  +      +      +     +    +  ++   +       A  ++   
Sbjct: 203 SHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQH 262

Query: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302
            D +  L K+  + +      K+K  LDFL +++ ++     E+   LSD +L A+   F
Sbjct: 263 TDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK----MENGSILSDKDLRAEVDTF 318

Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
           +F G++TT+S +S+ LY LATHP  Q++ ++EI  +L + A  T++ + QM Y  M + E
Sbjct: 319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKE 378

Query: 363 TLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSK 421
            LRL+P    + R     V   +G  +PKG MV++  Y LHH+PK W   E F P RF+ 
Sbjct: 379 ALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFA- 437

Query: 422 KKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKL 476
              +   + + PF  G RNCIG +FA+  +K+A    L  F   P   T+IP+ +
Sbjct: 438 PGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLP-DPTRIPIPM 491


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  139 bits (350), Expect = 6e-33
 Identities = 109/407 (26%), Positives = 193/407 (47%), Gaps = 30/407 (7%)

Query: 80  PVLAITDPDVIRTVLVKECYSVFTNR---RSLGPVGFMKSAISLAEDEEWKRIRSLLSPT 136
           P+L++  PD+IR+V+         ++     L P  ++   + L+  ++W R R +L+P 
Sbjct: 97  PLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEP--WLGDGLLLSAGDKWSRHRRMLTPA 154

Query: 137 FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKP-VTLKDIFGAYSMDVITGTSFGVNIDS 195
           F    LK    I  +  +++    +  A +G   + + +     ++D +    F  +   
Sbjct: 155 FHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHC 214

Query: 196 LNNPQDPFVESTKKFLKFGFL-----DPLFLSIILFPFLTPVFEALNVSL-FPKDTINFL 249
              P     E     L+   L       + L I    +LTP  +    +     D  + +
Sbjct: 215 QEKPS----EYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAV 270

Query: 250 SKSVNRMKKSR-----LNDKQKHR-LDFLQLMIDSQNSKETESHKALSDLELAAQSIIFI 303
            +   R   S+     L  K K + LDF+ +++ S++    E  K LSD ++ A++  F+
Sbjct: 271 IQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKD----EDGKKLSDEDIRAEADTFM 326

Query: 304 FAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP--TYDAVVQMEYLDMVVN 361
           F G++TT+S LS+ LY LA HP+ Q++ ++E+  +L ++ P    +D +  + +L M + 
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMK 386

Query: 362 ETLRLFPVAIRLERTCKKDVEI-NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS 420
           E+LRL P    + R   +D+ + +G  IPKG + +I  +  HH+P  W +PE + P RF 
Sbjct: 387 ESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFD 446

Query: 421 KKK-DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
            +      P  + PF  GPRNCIG  FA+  MK+ L   L  F   P
Sbjct: 447 PENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLP 493


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  139 bits (350), Expect = 6e-33
 Identities = 96/364 (26%), Positives = 182/364 (50%), Gaps = 15/364 (4%)

Query: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSM 181
           E  +W + R LL+P F    LK    +  +   +++     +A +GK   +    G  ++
Sbjct: 130 EGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMAL 189

Query: 182 DVITGTSFGVNIDSLNNPQDPF---VESTKKFLKFGFLDPLFLSIILFPFLTP----VFE 234
           + +   +FG     L +    +   V      ++   +   + +  ++ +LTP       
Sbjct: 190 NTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIY-WLTPHGRRFLR 248

Query: 235 ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLE 294
           A  V+    D +    K+  + +K R   + +  LDFL +++ +++  + +    LSD +
Sbjct: 249 ACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIK----LSDAD 304

Query: 295 LAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQME 354
           L A+   F+F G++TT+S +S+ LY +A +P+ Q + ++E+  +L ++    +D + +M 
Sbjct: 305 LRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMT 364

Query: 355 YLDMVVNETLRLFPVAIRLERTCKKDVE-INGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413
           YL M + E+ RL+P   ++ R   K V  ++G  +P GS++ +  YALH +   W +PE 
Sbjct: 365 YLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEV 424

Query: 414 FRPERFSKKKDS-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472
           F   RFS +  S   P+ + PF  GPRNCIG +FA+  MK+     L  F F     +++
Sbjct: 425 FDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFS-LDPSRL 483

Query: 473 PLKL 476
           P+K+
Sbjct: 484 PIKM 487


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score =  130 bits (328), Expect = 2e-30
 Identities = 108/347 (31%), Positives = 172/347 (49%), Gaps = 22/347 (6%)

Query: 160 LRREAEKGKPVT-LKDIFGAYSMDVITGTSFGVNIDSLNN--PQ--DPFVESTKKFLKFG 214
           LR +AE G+ VT + D+F  YSM+ +    +   +  L N  PQ    ++E+ +  L F 
Sbjct: 36  LRSQAEDGETVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALE--LMFS 93

Query: 215 FLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQL 274
                  +  +  +L P          PK    F        K S+++   K R    Q+
Sbjct: 94  MFKTSMYAGAIPRWLRP--------FIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQM 145

Query: 275 MIDSQNSKETESH----KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQK 330
               + S    ++    +AL+  E+ A     + AG +TTS  LS+T+Y LA HP+VQQ 
Sbjct: 146 DRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQT 205

Query: 331 LQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPK 390
           + +EI   L  +  PT   V ++  +  ++ ETLRLFPV     R  ++D+ I G  IPK
Sbjct: 206 VYREIVKNLGERHVPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPK 265

Query: 391 GSMVVIPTYALHHDPKYWTEPEEFRPERFSKK--KDSIDPYIYTPFGTGPRNCIGMRFAL 448
           G+ + +  YA  +  + +   +EFRPER+ +K   D +D +   PFG G R+CIG R A 
Sbjct: 266 GTQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAE 325

Query: 449 MNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSR 495
           + + L +I++LQ+F  K   +T   +   T GLL P  PI ++  +R
Sbjct: 326 LEIHLVVIQLLQHFEIKTSSQTN-AVHAKTHGLLTPGGPIHVRFVNR 371


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  128 bits (322), Expect = 1e-29
 Identities = 135/486 (27%), Positives = 215/486 (44%), Gaps = 43/486 (8%)

Query: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKM 71
           L+L +S +LL     ++ G  K    PGPTPLP++GN+L    + + K  T   K YG +
Sbjct: 7   LVLCLSCLLLLSLWRQSSGRGKLP--PGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPV 64

Query: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKS---AISLAEDEEWKR 128
           +  Y G  P++ +   + ++  L+ +    F+ R  + P+    +    I  +  ++WK 
Sbjct: 65  FTLYFGLKPIVVLHGYEAVKEALI-DLGEEFSGR-GIFPLAERANRGFGIVFSNGKKWKE 122

Query: 129 IRSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185
           IR     T   F  GK + +   + +    LV  LR+   K  P     I G    +VI 
Sbjct: 123 IRRFSLMTLRNFGMGK-RSIEDRVQEEARCLVEELRKT--KASPCDPTFILGCAPCNVIC 179

Query: 186 GTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDT 245
              F    D  +      +E   + +K   L   ++ I      +P+     +  FP  T
Sbjct: 180 SIIFHKRFDYKDQQFLNLMEKLNENIKI--LSSPWIQIC--NNFSPI-----IDYFP-GT 229

Query: 246 INFLSKSVNRMKKSRLNDKQKHR--------LDFLQLMIDSQNSKETESHKALSDLELAA 297
            N L K+V  MK   L   ++H+         DF+   +  +  KE  +  +   +E   
Sbjct: 230 HNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFL-MKMEKEKHNQPSEFTIESLE 288

Query: 298 QSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYL 356
            + + +F AG ETTS+ L + L  L  HP+V  K+Q+EI+ V+     P       M Y 
Sbjct: 289 NTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYT 348

Query: 357 DMVVNETLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEE 413
           D VV+E  R   L P ++    TC  D++     IPKG+ ++I   ++ HD K +  PE 
Sbjct: 349 DAVVHEVQRYIDLLPTSLPHAVTC--DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEM 406

Query: 414 FRPERFSKKKDSIDPYIY-TPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQI 472
           F P  F  +  +     Y  PF  G R C+G   A M + L L  +LQNF+ K   +   
Sbjct: 407 FDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVD--- 463

Query: 473 PLKLDT 478
           P  LDT
Sbjct: 464 PKNLDT 469


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  126 bits (316), Expect = 5e-29
 Identities = 122/465 (26%), Positives = 199/465 (42%), Gaps = 27/465 (5%)

Query: 13  LLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSY-RQGLWKFDTECYKKYGKM 71
           L LA+   LL L   R      RL  PGP PLPLLGN+L   R+GL K      +KYG +
Sbjct: 7   LFLALLTGLLLLLVQRHPNTHDRLP-PGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDV 65

Query: 72  WGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRI 129
           +  + G  PV+ +   + IR  LV +    F+ R  +  V   F    +  A    WK +
Sbjct: 66  FTVHLGPRPVVMLCGVEAIREALVDKA-EAFSGRGKIAMVDPFFRGYGVIFANGNRWKVL 124

Query: 130 RSLLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITG 186
           R     T   F  GK + +   I +    L+  LR+   KG  +    +F + + ++I  
Sbjct: 125 RRFSVTTMRDFGMGK-RSVEERIQEEAQCLIEELRKS--KGALMDPTFLFQSITANIICS 181

Query: 187 TSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSII-LFPFLTPVFEALNVSLFPK- 243
             FG      +     F++    F + F  +  +F  +  LF      F   +  ++   
Sbjct: 182 IVFGKRF---HYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNL 238

Query: 244 DTIN-FLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302
             IN ++  SV + +++      K  +D   L ++ + S    +H   S   L   ++  
Sbjct: 239 QEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSN---AHSEFSHQNLNLNTLSL 295

Query: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNE 362
            FAG ETTS+ L +    +  +P V +++ +EI+ V+    PP      +M Y + V+ E
Sbjct: 296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYE 355

Query: 363 TLR---LFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF 419
             R   L P+ +       +     G  IPK + V +      HDP Y+ +P+ F P+ F
Sbjct: 356 IQRFSDLLPMGV--PHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHF 413

Query: 420 SKKKDSI-DPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFS 463
                ++     + PF  G R C+G   A   + L    +LQNFS
Sbjct: 414 LDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS 458


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  125 bits (313), Expect = 1e-28
 Identities = 107/450 (23%), Positives = 195/450 (43%), Gaps = 25/450 (5%)

Query: 39  PGPTPLPLLGNVLSYRQGLWKFDTECY-KKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97
           PGP  LP LGN           + + + KKYG ++    G +  + IT   +I+  L+  
Sbjct: 45  PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHM 104

Query: 98  CYSVFTNRRSLGPVG---FMKSAISLAEDEEWKRIRSLLSPT---FTSGKLKEMFPIIAQ 151
             +     R + P+    F K+ + ++  + WK  R         F  GK K +   I +
Sbjct: 105 DQNF--GNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGK-KSLEERIQE 161

Query: 152 YGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFL 211
               L   ++ E   G+P            ++I   +FG   +     QD + +   K L
Sbjct: 162 EAQHLTEAIKEE--NGQPFDPHFKINNAVSNIICSITFGERFEY----QDSWFQQLLKLL 215

Query: 212 -KFGFLDPLFLSII--LFPFLTPVFEALNVSLFP--KDTINFLSKSVNRMKKSRLNDKQK 266
            +  +L+      +  +FP++       + +LF   K    F+S  +++ +K     + +
Sbjct: 216 DEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETR 275

Query: 267 HRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPD 326
              DF+   +   +        +  +  L   ++   FAG ETTS+ L + L  +A +P+
Sbjct: 276 ---DFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPE 332

Query: 327 VQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVA-IRLERTCKKDVEING 385
           +Q+K+Q EID V+     P+  A   M Y + V++E  R+  +  + + R    D  + G
Sbjct: 333 IQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAG 392

Query: 386 VFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMR 445
             +PKG+M++    ALH DP  W  P+ F P+ F +         + PF  G R C+G +
Sbjct: 393 YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQ 452

Query: 446 FALMNMKLALIRVLQNFSFKPCKETQIPLK 475
            A   + +    ++Q F+F+P    ++ LK
Sbjct: 453 LARTELFIFFTSLMQKFTFRPPNNEKLSLK 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.412 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,486,601
Number of Sequences: 37866
Number of extensions: 815274
Number of successful extensions: 1958
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1696
Number of HSP's gapped (non-prelim): 121
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.