Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4502573
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 772 0.0
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 759 0.0
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 597 e-171
gi|15431332 caspase 1 isoform delta [Homo sapiens] 477 e-135
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 368 e-102
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 342 3e-94
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 341 7e-94
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 341 7e-94
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 337 8e-93
gi|209870073 caspase 5 isoform c [Homo sapiens] 323 2e-88
gi|209870075 caspase 5 isoform d [Homo sapiens] 261 6e-70
gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 229 4e-60
gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE iso... 175 5e-44
gi|55925612 caspase recruitment domain family, member 17 [Homo s... 152 4e-37
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 152 6e-37
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 110 2e-24
gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens] 97 2e-20
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 83 4e-16
gi|14790115 caspase 3 preproprotein [Homo sapiens] 80 3e-15
gi|14790119 caspase 3 preproprotein [Homo sapiens] 80 3e-15
gi|6912286 caspase 14 precursor [Homo sapiens] 80 4e-15
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 77 3e-14
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 77 3e-14
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 76 4e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens] 69 5e-12
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 69 5e-12
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 69 5e-12
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 65 1e-10
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 65 1e-10
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 65 1e-10
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 772 bits (1993), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA 120
VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA 120
Query: 121 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD 180
QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD
Sbjct: 121 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD 180
Query: 181 VKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAI 240
VKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAI
Sbjct: 181 VKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAI 240
Query: 241 FNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA 300
FNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA
Sbjct: 241 FNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA 300
Query: 301 HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPD 360
HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPD
Sbjct: 301 HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPD 360
Query: 361 GRAQMPTTERVTLTRCFYLFPGH 383
GRAQMPTTERVTLTRCFYLFPGH
Sbjct: 361 GRAQMPTTERVTLTRCFYLFPGH 383
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 759 bits (1961), Expect = 0.0
Identities = 383/404 (94%), Positives = 383/404 (94%), Gaps = 21/404 (5%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSA---------------------APQAVQDN 99
VIPKGAQACQICITYICEEDSYLAGTLGLSA APQAVQDN
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
Query: 100 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 159
PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT
Sbjct: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
Query: 160 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 219
GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR
Sbjct: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
Query: 220 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 279
EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG
Sbjct: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
Query: 280 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 339
VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY
Sbjct: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
Query: 340 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 597 bits (1540), Expect = e-171
Identities = 292/295 (98%), Positives = 293/295 (99%)
Query: 89 LSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 148
+ APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC
Sbjct: 17 MGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 76
Query: 149 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 208
NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS
Sbjct: 77 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 136
Query: 209 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS 268
TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS
Sbjct: 137 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS 196
Query: 269 PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF 328
PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF
Sbjct: 197 PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF 256
Query: 329 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 257 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 477 bits (1227), Expect = e-135
Identities = 244/295 (82%), Positives = 245/295 (83%), Gaps = 48/295 (16%)
Query: 89 LSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 148
+ APQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC
Sbjct: 17 MGEAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIIC 76
Query: 149 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 208
NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS
Sbjct: 77 NEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDS 136
Query: 209 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS 268
TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD
Sbjct: 137 TFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD- 195
Query: 269 PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVF 328
NVSWRHPTMGSVF
Sbjct: 196 -----------------------------------------------NVSWRHPTMGSVF 208
Query: 329 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH
Sbjct: 209 IGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263
Score = 40.0 bits (92), Expect = 0.004
Identities = 19/19 (100%), Positives = 19/19 (100%)
Query: 1 MADKVLKEKRKLFIRSMGE 19
MADKVLKEKRKLFIRSMGE
Sbjct: 1 MADKVLKEKRKLFIRSMGE 19
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 368 bits (944), Expect = e-102
Identities = 196/384 (51%), Positives = 257/384 (66%), Gaps = 8/384 (2%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MA+ ++K + S+G+ + G+LD L++ VLN +E EK K +A DK R + DS
Sbjct: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSG-SEGNVKLCSLEE 119
+ K A Q+ + D +S +A + A P SG S +KLC EE
Sbjct: 61 MQEKQRMAGQMLLQTFFNIDQ-------ISPNKKAHPNMEAGPPESGESTDALKLCPHEE 113
Query: 120 AQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSV 179
R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+ DITGM LL+ L YSV
Sbjct: 114 FLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSV 173
Query: 180 DVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNA 239
DV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H E+ PD+L +
Sbjct: 174 DVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDT 233
Query: 240 IFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKK 299
IF + N +NC SLKDKPKVII+QACRG + G +W +DS S ++E E+DA+ K
Sbjct: 234 IFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYK 293
Query: 300 AHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQP 359
H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+ C +EE+FRKV+ SFE P
Sbjct: 294 THVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETP 353
Query: 360 DGRAQMPTTERVTLTRCFYLFPGH 383
+AQMPT ER+++TR FYLFPG+
Sbjct: 354 RAKAQMPTIERLSMTRYFYLFPGN 377
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 342 bits (878), Expect = 3e-94
Identities = 187/383 (48%), Positives = 239/383 (62%), Gaps = 7/383 (1%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MA+ K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS
Sbjct: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA 120
+ K A Q+ + D + L +Q P S+ S +KLC EE
Sbjct: 61 -LRKNRVAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEF 113
Query: 121 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD 180
R+ K+ EIYPI + R RLALIICN +FD +P R GA DI GM LLQ LGY+V
Sbjct: 114 LRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVV 173
Query: 181 VKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAI 240
+KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H ++ PD+L + I
Sbjct: 174 DEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTI 233
Query: 241 FNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA 300
F + N +NC SLKDKPKVII+QACRG+ G +W +DS +S ++E E D++ K
Sbjct: 234 FQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKI 293
Query: 301 HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPD 360
H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE P
Sbjct: 294 HEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQ 353
Query: 361 GRAQMPTTERVTLTRCFYLFPGH 383
+AQMPT ER TLTR FYLFPG+
Sbjct: 354 AKAQMPTIERATLTRDFYLFPGN 376
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 341 bits (874), Expect = 7e-94
Identities = 185/377 (49%), Positives = 236/377 (62%), Gaps = 7/377 (1%)
Query: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 78 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 136
Query: 67 QACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQ 126
A Q+ + D + L +Q P S+ S +KLC EE R+ K+
Sbjct: 137 VAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEFLRLCKK 190
Query: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
EIYPI + R RLALIICN +FD +P R GA DI GM LLQ LGY+V +KNLT
Sbjct: 191 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 250
Query: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
A DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H ++ PD+L + IF + N
Sbjct: 251 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 310
Query: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
+NC SLKDKPKVII+QACRG+ G +W +DS +S ++E E D++ K H EKDF
Sbjct: 311 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 370
Query: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366
IAFCSSTP NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE P +AQMP
Sbjct: 371 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 430
Query: 367 TTERVTLTRCFYLFPGH 383
T ER TLTR FYLFPG+
Sbjct: 431 TIERATLTRDFYLFPGN 447
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 341 bits (874), Expect = 7e-94
Identities = 185/377 (49%), Positives = 236/377 (62%), Gaps = 7/377 (1%)
Query: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 65 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 123
Query: 67 QACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQ 126
A Q+ + D + L +Q P S+ S +KLC EE R+ K+
Sbjct: 124 VAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEFLRLCKK 177
Query: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
EIYPI + R RLALIICN +FD +P R GA DI GM LLQ LGY+V +KNLT
Sbjct: 178 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 237
Query: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
A DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H ++ PD+L + IF + N
Sbjct: 238 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 297
Query: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
+NC SLKDKPKVII+QACRG+ G +W +DS +S ++E E D++ K H EKDF
Sbjct: 298 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 357
Query: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366
IAFCSSTP NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE P +AQMP
Sbjct: 358 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 417
Query: 367 TTERVTLTRCFYLFPGH 383
T ER TLTR FYLFPG+
Sbjct: 418 TIERATLTRDFYLFPGN 434
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 337 bits (865), Expect = 8e-93
Identities = 166/281 (59%), Positives = 208/281 (74%)
Query: 103 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 162
P S S +KLC EE R+ K+++ EIYPI ++++RTRLALIICN EFD +P R GA+
Sbjct: 41 PESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGAD 100
Query: 163 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 222
DITGM LL+ L YSVDV++NLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 101 FDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGI 160
Query: 223 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 282
CG H E+ PD+L + IF + N +NC SLKDKPKVII+QACRG + G +W +DS
Sbjct: 161 CGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLE 220
Query: 283 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 342
S ++E E+DA+ K H+EKDFIAFCSSTP NVSWR TMGS+FI +LI Q+Y+
Sbjct: 221 VASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWC 280
Query: 343 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
C +EE+FRKV+ SFE P +AQMPT ER+++TR FYLFPG+
Sbjct: 281 CHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN 321
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 103 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 162
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 12 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 71
Query: 163 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 222
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 72 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 131
Query: 223 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 282
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 132 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 191
Query: 283 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 342
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 192 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 251
Query: 343 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 252 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 261 bits (668), Expect = 6e-70
Identities = 130/216 (60%), Positives = 156/216 (72%)
Query: 168 MTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKH 227
M LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 228 SEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLP 287
++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 288 TTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEE 347
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C + E
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 348 IFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 383
IFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|62953113 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 1 [Homo sapiens]
Length = 197
Score = 229 bits (583), Expect = 4e-60
Identities = 116/127 (91%), Positives = 119/127 (93%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFI SMGEGTINGLLDELLQTRVLN+EEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA 120
VIPKGAQACQICITYICEEDSYLA TLGLSAA QAVQDNPAMPT S EG +KLC LE+A
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGLSAALQAVQDNPAMPTCSSPEGRIKLCFLEDA 120
Query: 121 QRIWKQK 127
QRIWKQK
Sbjct: 121 QRIWKQK 127
>gi|16751833 caspase-1 dominant-negative inhibitor pseudo-ICE
isoform 2 [Homo sapiens]
Length = 97
Score = 175 bits (444), Expect = 5e-44
Identities = 89/93 (95%), Positives = 90/93 (96%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRKLFI SMGEGTINGLLDELLQTRVLN+EEMEKVKRENATVMDKTRALIDS
Sbjct: 1 MADKVLKEKRKLFIHSMGEGTINGLLDELLQTRVLNQEEMEKVKRENATVMDKTRALIDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAP 93
VIPKGAQACQICITYICEEDSYLA TLGLSA P
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAETLGLSAGP 93
>gi|55925612 caspase recruitment domain family, member 17 [Homo
sapiens]
Length = 110
Score = 152 bits (385), Expect = 4e-37
Identities = 78/93 (83%), Positives = 85/93 (91%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MADKVLKEKRK FIRS+GEGTINGLL ELL+TRVL++EE+E VK ENATVMDK RAL+DS
Sbjct: 1 MADKVLKEKRKQFIRSVGEGTINGLLGELLETRVLSQEEIEIVKCENATVMDKARALLDS 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAP 93
VI KGA ACQICITYICEEDS+LAGTLGLSA P
Sbjct: 61 VIRKGAPACQICITYICEEDSHLAGTLGLSAGP 93
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 152 bits (383), Expect = 6e-37
Identities = 72/81 (88%), Positives = 73/81 (90%)
Query: 303 EKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 362
EK + S DNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR
Sbjct: 8 EKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGR 67
Query: 363 AQMPTTERVTLTRCFYLFPGH 383
AQMPTTERVTLTRCFYLFPGH
Sbjct: 68 AQMPTTERVTLTRCFYLFPGH 88
Score = 41.2 bits (95), Expect = 0.002
Identities = 19/23 (82%), Positives = 21/23 (91%)
Query: 1 MADKVLKEKRKLFIRSMGEGTIN 23
MADKVLKEKRKLFIRSMGE ++
Sbjct: 1 MADKVLKEKRKLFIRSMGEDNVS 23
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 110 bits (275), Expect = 2e-24
Identities = 84/263 (31%), Positives = 120/263 (45%), Gaps = 27/263 (10%)
Query: 139 SRTR-LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTEL 194
SR R LAL++ N F + R+G +VD + + L + LGY V V + TA +M +L
Sbjct: 196 SRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKL 255
Query: 195 EAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKD 254
+ FA P H+ +DS + +SHG+ I G +LQL +F + + NCPSL++
Sbjct: 256 QNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQN 310
Query: 255 KPKVIIIQACRGDSP--GVVWFKDSVGVSGNLSLPTTEEFEDDAIK----KAHIEKDFIA 308
KPK+ IQACRGD GV D + P EE + K + D I
Sbjct: 311 KPKMFFIQACRGDETDRGV----DQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMIC 366
Query: 309 FCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPTT 368
+ + R+ GS +I L + E AC V ++ KV + +G A
Sbjct: 367 GYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEF 426
Query: 369 ERV--------TLTRCFYLFPGH 383
R TL R YLFPGH
Sbjct: 427 HRCKEMSEYCSTLCRHLYLFPGH 449
>gi|10954343 ICEBERG caspase-1 inhibitor [Homo sapiens]
Length = 90
Score = 97.4 bits (241), Expect = 2e-20
Identities = 48/89 (53%), Positives = 66/89 (74%)
Query: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
MAD++L++KR++FI S+G GTIN LLD LL+ V+++E+M KV+ EN TVMDK R LID
Sbjct: 1 MADQLLRKKRRIFIHSVGAGTINALLDCLLEDEVISQEDMNKVRDENDTVMDKARVLIDL 60
Query: 61 VIPKGAQACQICITYICEEDSYLAGTLGL 89
V KG ++C I ++CEED LA +GL
Sbjct: 61 VTGKGPKSCCKFIKHLCEEDPQLASKMGL 89
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 83.2 bits (204), Expect = 4e-16
Identities = 99/406 (24%), Positives = 163/406 (40%), Gaps = 63/406 (15%)
Query: 10 RKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENA-TVMDKTRALIDSVIPKGAQA 68
R+ +R + E ++ L D LL + +E ++R + + D+ R LI + +G+QA
Sbjct: 10 RRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQA 69
Query: 69 CQICITYICEEDS---YLAGTLGLSAA-----------------------PQAVQDNPAM 102
+ I+ C ED+ LA L + P+ ++
Sbjct: 70 LPLFIS--CLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPR 127
Query: 103 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEF---DSIPRRT 159
P GS G + +LE + +A++ I+ LII N F + RT
Sbjct: 128 PVDIGSGGFGDVGALESLRG-----NADLAYILSMEPCGH-CLIINNVNFCRESGLRTRT 181
Query: 160 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 219
G+ +D + +L + V+VK +LTA M L A + +H D +V +SHG
Sbjct: 182 GSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVILSHG-- 238
Query: 220 EGICGKKHSEQVPDI-------LQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPG-- 270
C H + + + + I N+ N +CPSL KPK+ IQAC G+
Sbjct: 239 ---CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHG 295
Query: 271 --VVWFKDSVGVSGNLSLPTTEEFED--------DAIKKAHIEKDFIAFCSSTPDNVSWR 320
V G+ P F++ DAI D S+ P VSWR
Sbjct: 296 FEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWR 355
Query: 321 HPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366
P GS ++ L + +++A S D++ + +V + QMP
Sbjct: 356 DPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMP 401
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 143 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 199
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 200 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 259
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 260 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 318
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 319 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 357
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 80.1 bits (196), Expect = 3e-15
Identities = 69/223 (30%), Positives = 96/223 (43%), Gaps = 28/223 (12%)
Query: 143 LALIICNEEFDS---IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAH 199
L +II N+ F + R+G +VD + +NL Y V K +LT ++ EL
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIV-ELMRDVS 104
Query: 200 RPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVI 259
+ +H S V +SHG EGI + + L I N C SL KPK+
Sbjct: 105 KEDHSKRSSFVCVLLSHG-EEGIIFGTNGP-----VDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 260 IIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDD-AIKKAHIEKDFIAFCSSTPDNVS 318
IIQACRG + + T +DD A K +E DF+ S+ P S
Sbjct: 159 IIQACRGTEL-------------DCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYS 205
Query: 319 WRHPTMGSVFIGRLIEHMQEYACSCDVEEIF----RKVRFSFE 357
WR+ GS FI L +++YA + I RKV FE
Sbjct: 206 WRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFE 248
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 79.7 bits (195), Expect = 4e-15
Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 38/253 (15%)
Query: 139 SRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFA 198
S RLALI+C + R G+E D+ + + + L + +K++ TA ELE F
Sbjct: 15 SGARLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQ 69
Query: 199 HRPEHKTS--DSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKP 256
+ + F+V M+HG REG + E V +L +F LN KNC +L+ KP
Sbjct: 70 QAIDSREDPVSCAFVVLMAHG-REGFLKGEDGEMV----KLENLFEALNNKNCQALRAKP 124
Query: 257 KVIIIQACRGD--SPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTP 314
KV IIQACRG+ PG D + + S T + D H+ S+
Sbjct: 125 KVYIIQACRGEQRDPGETVGGDEIVMVIKDSPQTIPTYTD----ALHV-------YSTVE 173
Query: 315 DNVSWRHPTMGSVFIGRLIE-------HMQEYACSCDVEEIFRKVRFSFEQPDGRAQMPT 367
+++RH GS FI L++ H+ E + E+ R++ + +G+A+
Sbjct: 174 GYIAYRHDQKGSCFIQTLVDVFTKRKGHILEL-----LTEVTRRMAEAELVQEGKARKTN 228
Query: 368 TE-RVTLTRCFYL 379
E + TL + YL
Sbjct: 229 PEIQSTLRKRLYL 241
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 338
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 77.0 bits (188), Expect = 3e-14
Identities = 58/212 (27%), Positives = 95/212 (44%), Gaps = 14/212 (6%)
Query: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
K A +Y M+++ R L +I+ N F S+ R G D ++ + Q LG++V + N+T
Sbjct: 271 KRAAVYR-MNRNHRG-LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVT 328
Query: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
+M L+ P H D ++HG R G +P + I +
Sbjct: 329 KVEMEMVLQKQKCNPAHADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTA 383
Query: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
CP L +KPK+ IQAC+G+ + SV + + P E+ E DF
Sbjct: 384 LQCPRLAEKPKLFFIQACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADF 436
Query: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQE 338
+ ++ P VS+RH GS +I L H+++
Sbjct: 437 LLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 76.3 bits (186), Expect = 4e-14
Identities = 53/196 (27%), Positives = 86/196 (43%), Gaps = 12/196 (6%)
Query: 143 LALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPE 202
L +I+ N F S+ R G D ++ + Q LG++V + N+T +M L+ P
Sbjct: 242 LCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPA 301
Query: 203 HKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQ 262
H D ++HG R G +P + I + CP L +KPK+ IQ
Sbjct: 302 HADGDCFVFCILTHG-RFGAVYSSDEALIP----IREIMSHFTALQCPRLAEKPKLFFIQ 356
Query: 263 ACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHP 322
AC+G+ + SV + + P E+ E DF+ ++ P VS+RH
Sbjct: 357 ACQGEE-----IQPSVSIEADALNP--EQAPTSLQDSIPAEADFLLGLATVPGYVSFRHV 409
Query: 323 TMGSVFIGRLIEHMQE 338
GS +I L H+++
Sbjct: 410 EEGSWYIQSLCNHLKK 425
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 69.3 bits (168), Expect = 5e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 145 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 201
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 104 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 162
Query: 202 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 261
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 163 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 216
Query: 262 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 321
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 217 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 267
Query: 322 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 352
P GS F+ L ++E+ ++ +I +V
Sbjct: 268 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 298
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 5e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 145 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 201
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 202 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 261
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 262 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 321
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 322 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 352
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 69.3 bits (168), Expect = 5e-12
Identities = 58/211 (27%), Positives = 92/211 (43%), Gaps = 19/211 (9%)
Query: 145 LIICNEEFDSIPR---RTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRP 201
+II N+ FD + R G + D + ++LG+ V V + + + M L+ A
Sbjct: 71 IIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEE 129
Query: 202 EHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIII 261
+H + + +SHG I GK + V I L A F C +L +KPK+ I
Sbjct: 130 DHTNAACFACILLSHGEENVIYGK---DGVTPIKDLTAHFR---GDRCKTLLEKPKLFFI 183
Query: 262 QACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRH 321
QACRG DS ++ + P K +E DF+ S+ P SWR
Sbjct: 184 QACRGTELDDGIQADSGPINDTDANPRY---------KIPVEADFLFAYSTVPGYYSWRS 234
Query: 322 PTMGSVFIGRLIEHMQEYACSCDVEEIFRKV 352
P GS F+ L ++E+ ++ +I +V
Sbjct: 235 PGRGSWFVQALCSILEEHGKDLEIMQILTRV 265
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 106 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 154
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 256 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 315
Query: 155 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 214
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 316 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 374
Query: 215 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 269
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 375 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 429
Query: 270 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 329
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 430 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 481
Query: 330 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 365
L + ++E D+ I +V + D + M
Sbjct: 482 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 518
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 65.1 bits (157), Expect = 1e-10
Identities = 68/277 (24%), Positives = 115/277 (41%), Gaps = 31/277 (11%)
Query: 106 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTR-LALIICNEEF----------DS 154
S E + ++ ++ R +S + + S+ R LII N F S
Sbjct: 197 SNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHS 256
Query: 155 IPRRTGAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFM 214
I R G +D +T + L + + + T + L+ + +H D +
Sbjct: 257 IRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIY-QLMDHSNMDCFICCIL 315
Query: 215 SHGIREGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDS-----P 269
SHG + GI ++ P I +L + F L CPSL KPKV IQAC+GD+ P
Sbjct: 316 SHGDK-GIIYGTDGQEAP-IYELTSQFTGLK---CPSLAGKPKVFFIQACQGDNYQKGIP 370
Query: 270 GVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFI 329
++ + +LS P T D+A DF+ ++ + VS+R+P G+ +I
Sbjct: 371 VETDSEEQPYLEMDLSSPQTRYIPDEA--------DFLLGMATVNNCVSYRNPAEGTWYI 422
Query: 330 GRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPDGRAQM 365
L + ++E D+ I +V + D + M
Sbjct: 423 QSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNM 459
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 64.7 bits (156), Expect = 1e-10
Identities = 64/245 (26%), Positives = 102/245 (41%), Gaps = 30/245 (12%)
Query: 137 KSSRTRLALIICNEEF----------DSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
KS LII N F SI R G +D +T + L + + + T
Sbjct: 214 KSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCT 273
Query: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
+ L+ + +H D +SHG + GI ++ P I +L + F L
Sbjct: 274 VEQIYEILKIY-QLMDHSNMDCFICCILSHGDK-GIIYGTDGQEAP-IYELTSQFTGLK- 329
Query: 247 KNCPSLKDKPKVIIIQACRGDS-----PGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAH 301
CPSL KPKV IQAC+GD+ P ++ + +LS P T D+A
Sbjct: 330 --CPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEA----- 382
Query: 302 IEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYA-CSCDVEEIFRKVRFSFEQPD 360
DF+ ++ + VS+R+P G+ +I L + ++E D+ I +V + D
Sbjct: 383 ---DFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDILTILTEVNYEVSNKD 439
Query: 361 GRAQM 365
+ M
Sbjct: 440 DKKNM 444
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,422,485
Number of Sequences: 37866
Number of extensions: 615131
Number of successful extensions: 1727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1648
Number of HSP's gapped (non-prelim): 65
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.