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Search of human proteins with 4502461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502461 betacellulin [Homo sapiens]
(178 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502461 betacellulin [Homo sapiens] 369 e-103
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap... 78 5e-15
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s... 76 2e-14
gi|29568105 transmembrane protein with EGF-like and two follista... 67 6e-12
gi|12383051 transmembrane protein with EGF-like and two follista... 61 4e-10
gi|4557567 epiregulin preproprotein [Homo sapiens] 56 1e-08
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens] 53 2e-07
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 48 5e-06
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 47 7e-06
gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens] 47 9e-06
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 47 1e-05
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 46 1e-05
gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens] 44 6e-05
gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens] 44 6e-05
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 44 6e-05
gi|4502199 amphiregulin preproprotein [Homo sapiens] 43 2e-04
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens] 43 2e-04
gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens] 42 4e-04
gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens] 42 4e-04
gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens] 42 4e-04
gi|66730481 neuregulin 3 [Homo sapiens] 41 5e-04
gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens] 40 0.001
gi|61806622 epithelial mitogen [Homo sapiens] 39 0.002
gi|20070380 neuregulin 4 [Homo sapiens] 39 0.003
gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens] 37 0.007
gi|93102379 low density lipoprotein-related protein 1B precursor... 37 0.007
gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens] 37 0.012
gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens] 37 0.012
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 36 0.015
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 35 0.026
>gi|4502461 betacellulin [Homo sapiens]
Length = 178
Score = 369 bits (947), Expect = e-103
Identities = 178/178 (100%), Positives = 178/178 (100%)
Query: 1 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS 60
MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS
Sbjct: 1 MDRAARCSGASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQS 60
Query: 61 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL 120
KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL
Sbjct: 61 KRKGHFSRCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQIL 120
Query: 121 VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA 178
VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA
Sbjct: 121 VICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMETLGKDITPINEDIEETNIA 178
>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
Length = 160
Score = 77.8 bits (190), Expect = 5e-15
Identities = 46/135 (34%), Positives = 67/135 (49%), Gaps = 15/135 (11%)
Query: 16 LLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKH 75
L ALG+V+ C + NST SP L DP A + HF+ CP +
Sbjct: 8 LALFALGIVLAACQALE-NST-SP-----LSADPPVAAAVVS-------HFNDCPDSHTQ 53
Query: 76 YCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLF-YLRGDRGQILVICLIAVMVVFIIL 134
+C G CRF+V E P+CVC GY+GARCE DL + + + + L+ V +V + +
Sbjct: 54 FCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAV 113
Query: 135 VIGVCTCCHPLRKRR 149
+I C H + R+
Sbjct: 114 LIITCVLIHCCQVRK 128
>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
sapiens]
Length = 159
Score = 75.9 bits (185), Expect = 2e-14
Identities = 45/135 (33%), Positives = 66/135 (48%), Gaps = 16/135 (11%)
Query: 16 LLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKH 75
L ALG+V+ C + NST SP DP A + HF+ CP +
Sbjct: 8 LALFALGIVLAACQALE-NST-SP------LSDPPVAAAVVS-------HFNDCPDSHTQ 52
Query: 76 YCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLF-YLRGDRGQILVICLIAVMVVFIIL 134
+C G CRF+V E P+CVC GY+GARCE DL + + + + L+ V +V + +
Sbjct: 53 FCFHGTCRFLVQEDKPACVCHSGYVGARCEHADLLAVVAASQKKQAITALVVVSIVALAV 112
Query: 135 VIGVCTCCHPLRKRR 149
+I C H + R+
Sbjct: 113 LIITCVLIHCCQVRK 127
>gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
Length = 380
Score = 67.4 bits (163), Expect = 6e-12
Identities = 38/134 (28%), Positives = 61/134 (45%), Gaps = 6/134 (4%)
Query: 27 HCVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVV 86
HC D S + +GL P+ A+ + G+ CP+ YCI G+C F+
Sbjct: 234 HCTDTDDTSLLGKKDDGLQYR-PDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIY 292
Query: 87 AEQTPSCVCDEGYIGARCERVDLFYL-----RGDRGQILVICLIAVMVVFIILVIGVCTC 141
+ Q SC C+ GY G CE+ D L R +L+ +I + + II+ I +C
Sbjct: 293 STQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCIT 352
Query: 142 CHPLRKRRKRKKKE 155
+ R R++K+
Sbjct: 353 RKCPKNNRGRRQKQ 366
>gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
Length = 374
Score = 61.2 bits (147), Expect = 4e-10
Identities = 37/153 (24%), Positives = 64/153 (41%), Gaps = 27/153 (17%)
Query: 28 CVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSR------------------- 68
C + + + + + + G ++N TTT GH++R
Sbjct: 206 CQIKEASCQKQEKIEVMSLGRCQDN--TTTTTKSEDGHYARTDYAENANKLEESAREHHI 263
Query: 69 -CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRG-----QILVI 122
CP+ Y +C+ G+C + Q PSC CD GY G CE+ D L G +L+
Sbjct: 264 PCPEHYNGFCMHGKCEHSINMQEPSCRCDAGYTGQHCEKKDYSVLYVVPGPVRFQYVLIA 323
Query: 123 CLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKE 155
+I + + +I V+ +C R R ++K+
Sbjct: 324 AVIGTIQIAVICVVVLCITRKCPRSNRIHRQKQ 356
>gi|4557567 epiregulin preproprotein [Homo sapiens]
Length = 169
Score = 56.2 bits (134), Expect = 1e-08
Identities = 47/163 (28%), Positives = 72/163 (44%), Gaps = 12/163 (7%)
Query: 10 ASSLPLLLALALGLVILHCVVADGNSTRSPETNGLLCGDPEENCAAT--TTQSKRKGHFS 67
A +P LL L LG +L V++ +T P + G+ +NC A T + R S
Sbjct: 12 AGRVPALL-LCLGFHLLQAVLS---TTVIPSC---IPGESSDNCTALVQTEDNPRVAQVS 64
Query: 68 --RCPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQILVICLI 125
+C YC+ G+C ++V C C+ GY G RCE L + + + + +I
Sbjct: 65 ITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVI 124
Query: 126 AVMVVFIILVIGVCTCCHPLRKRR-KRKKKEEEMETLGKDITP 167
+++ I +V C R R+ K KKE E T G P
Sbjct: 125 LIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELP 167
>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
Length = 208
Score = 52.8 bits (125), Expect = 2e-07
Identities = 23/74 (31%), Positives = 40/74 (54%), Gaps = 4/74 (5%)
Query: 69 CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDL----FYLRGDRGQILVICL 124
C ++YK +CI G C++V + PSC+C GY G RC + L D IL +
Sbjct: 108 CLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTILAVVA 167
Query: 125 IAVMVVFIILVIGV 138
+ + V +++++G+
Sbjct: 168 VVLSSVCLLVIVGL 181
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 47.8 bits (112), Expect = 5e-06
Identities = 34/126 (26%), Positives = 61/126 (48%), Gaps = 18/126 (14%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIKGR-CRFVVAEQTPSCVCDEGYIGARCERVDL--F 110
+ +TT S GH +C + K YC+ G C ++ SC C GY G RC++ + F
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNF 389
Query: 111 YLRGDRGQILVICL----IAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEMET-LGKDI 165
+ Q V+ + +A++VV I+ V+ C K KK+ ++M L +++
Sbjct: 390 SKAEELYQKRVLTITGICVALLVVGIVCVVAYC----------KTKKQRKQMHNHLRQNM 439
Query: 166 TPINED 171
P +++
Sbjct: 440 CPAHQN 445
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 47.4 bits (111), Expect = 7e-06
Identities = 37/133 (27%), Positives = 61/133 (45%), Gaps = 26/133 (19%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIKGR-CRFVVAEQTPSCVCDEGYIGARC-ERVDLFY 111
+ +TT S GH +C + K YC+ G C ++ SC C G+ G RC E++ L
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRL 389
Query: 112 LRGDRGQ------------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159
D Q I IC +A++VV I+ V+ C K KK+ ++M
Sbjct: 390 YMPDPKQKAEELYQKRVLTITGIC-VALLVVGIVCVVAYC----------KTKKQRKQMH 438
Query: 160 T-LGKDITPINED 171
L +++ P +++
Sbjct: 439 NHLRQNMCPAHQN 451
>gi|236461846 neuregulin 1 isoform ndf43c [Homo sapiens]
Length = 308
Score = 47.0 bits (110), Expect = 9e-06
Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 22/118 (18%)
Query: 51 ENCAATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARC-E 105
E+ AT+T + H +C ++ K +C+ G C V PS C C G+ GARC E
Sbjct: 10 EDITATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTE 69
Query: 106 RVDLFYLRGDRGQ---------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
V + ++ + I IC IA++VV I+ V+ C K +K++KK
Sbjct: 70 NVPMKVQNQEKAEELYQKRVLTITGIC-IALLVVGIMCVVAYC-------KTKKQRKK 119
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 46.6 bits (109), Expect = 1e-05
Identities = 28/102 (27%), Positives = 49/102 (48%), Gaps = 9/102 (8%)
Query: 43 GLLCGD--PEENCAATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPSCVCDEGY 99
GL+C D P + + S CP + YC+ G C ++ A +C C GY
Sbjct: 948 GLICPDSTPPPHLREDDHHYSVRNSDSECPLSHDGYCLHDGVCMYIEALDKYACNCVVGY 1007
Query: 100 IGARCERVDLFYL------RGDRGQILVICLIAVMVVFIILV 135
IG RC+ DL + G + +++V+ + V++V ++L+
Sbjct: 1008 IGERCQYRDLKWWELRHAGHGQQQKVIVVAVCVVVLVMLLLL 1049
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 46.2 bits (108), Expect = 1e-05
Identities = 34/134 (25%), Positives = 60/134 (44%), Gaps = 26/134 (19%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIKGR-CRFVVAEQTPSCVCDEGYIGARCERVDLFYL 112
+ +TT S GH +C + K YC+ G C ++ SC C GY G RC++ +
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNF 389
Query: 113 RGDRG------------QILVI--CLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEM 158
G ++L I +A++VV I+ V+ C K KK+ ++M
Sbjct: 390 SKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYC----------KTKKQRKQM 439
Query: 159 ET-LGKDITPINED 171
L +++ P +++
Sbjct: 440 HNHLRQNMCPAHQN 453
>gi|7669526 neuregulin 1 isoform HRG-alpha [Homo sapiens]
Length = 640
Score = 44.3 bits (103), Expect = 6e-05
Identities = 34/115 (29%), Positives = 55/115 (47%), Gaps = 22/115 (19%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARC-ERVD 108
++T+T + H +C ++ K +C+ G C V PS C C G+ GARC E V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 226
Query: 109 LFYLRGDRGQ---------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
+ ++ + I IC IA++VV I+ V+ C K +K++KK
Sbjct: 227 MKVQNQEKAEELYQKRVLTITGIC-IALLVVGIMCVVAYC-------KTKKQRKK 273
>gi|7669520 neuregulin 1 isoform ndf43 [Homo sapiens]
Length = 462
Score = 44.3 bits (103), Expect = 6e-05
Identities = 34/115 (29%), Positives = 55/115 (47%), Gaps = 22/115 (19%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARC-ERVD 108
++T+T + H +C ++ K +C+ G C V PS C C G+ GARC E V
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVP 226
Query: 109 LFYLRGDRGQ---------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
+ ++ + I IC IA++VV I+ V+ C K +K++KK
Sbjct: 227 MKVQNQEKAEELYQKRVLTITGIC-IALLVVGIMCVVAYC-------KTKKQRKK 273
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 44.3 bits (103), Expect = 6e-05
Identities = 37/141 (26%), Positives = 61/141 (43%), Gaps = 34/141 (24%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIKGR-CRFVVAEQTPSCVCDEGYIGARC-ERVDLFY 111
+ +TT S GH +C + K YC+ G C ++ SC C G+ G RC E++ L
Sbjct: 330 SVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRL 389
Query: 112 LRGDRGQ--------------------ILVICLIAVMVVFIILVIGVCTCCHPLRKRRKR 151
D Q I IC +A++VV I+ V+ C K
Sbjct: 390 YMPDPKQKHLGFELKEAEELYQKRVLTITGIC-VALLVVGIVCVVAYC----------KT 438
Query: 152 KKKEEEMET-LGKDITPINED 171
KK+ ++M L +++ P +++
Sbjct: 439 KKQRKQMHNHLRQNMCPAHQN 459
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 42.7 bits (99), Expect = 2e-04
Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 69 CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDL---FYLRGDRGQILVICLI 125
C +++++CI G C+++ + +C C + Y G RC + + +I + +
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205
Query: 126 AVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159
A M I+ + V T LR++ RK + E E
Sbjct: 206 AFMSAVILTAVAVITV--QLRRQYVRKYEGEAEE 237
>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
Length = 252
Score = 42.7 bits (99), Expect = 2e-04
Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 5/94 (5%)
Query: 69 CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDL---FYLRGDRGQILVICLI 125
C +++++CI G C+++ + +C C + Y G RC + + +I + +
Sbjct: 146 CNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIA 205
Query: 126 AVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159
A M I+ + V T LR++ RK + E E
Sbjct: 206 AFMSAVILTAVAVITV--QLRRQYVRKYEGEAEE 237
>gi|236463556 neuregulin 1 isoform ndf43b [Homo sapiens]
Length = 459
Score = 41.6 bits (96), Expect = 4e-04
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 17/111 (15%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL 109
++T+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
Query: 110 --FYLRGDRGQILVICL----IAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY + Q V+ + IA++VV I+ V+ C K +K++KK
Sbjct: 227 ASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 270
>gi|236464528 neuregulin 1 isoform HRG-beta2b [Homo sapiens]
Length = 420
Score = 41.6 bits (96), Expect = 4e-04
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 17/111 (15%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL 109
++T+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
Query: 110 --FYLRGDRGQILVICL----IAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY + Q V+ + IA++VV I+ V+ C K +K++KK
Sbjct: 227 ASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 270
>gi|116006957 neuregulin 1 isoform HRG-beta2 [Homo sapiens]
Length = 637
Score = 41.6 bits (96), Expect = 4e-04
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 17/111 (15%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL 109
++T+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
Query: 110 --FYLRGDRGQILVICL----IAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY + Q V+ + IA++VV I+ V+ C K +K++KK
Sbjct: 227 ASFYKAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 270
>gi|66730481 neuregulin 3 [Homo sapiens]
Length = 696
Score = 41.2 bits (95), Expect = 5e-04
Identities = 36/154 (23%), Positives = 69/154 (44%), Gaps = 31/154 (20%)
Query: 32 DGNSTRSPETNGLLCGDPEENCA----ATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVV 86
D S+ S ++ PE + + TT ++R HF C + YC+ G C FV+
Sbjct: 249 DAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGEC-FVI 307
Query: 87 AEQTPS---CVCDEGYIGARCER---------------VDLFYLRGD---RGQILVICLI 125
T S C C EGY G RC++ + + ++ + + Q+L I I
Sbjct: 308 ETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCI 367
Query: 126 AVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159
+F I+++G+ + +++ K+ +E+++
Sbjct: 368 ----IFGIVIVGMFCAAFYFKSKKQAKQIQEQLK 397
>gi|236461509 neuregulin 1 isoform HRG-beta1c [Homo sapiens]
Length = 607
Score = 39.7 bits (91), Expect = 0.001
Identities = 36/138 (26%), Positives = 58/138 (42%), Gaps = 30/138 (21%)
Query: 40 ETNGLLCGDPEEN-----CAATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS- 92
E+N ++ G P +AT+T + H +C ++ K +C+ G C V PS
Sbjct: 110 ESNEIITGMPASTEGAYVSSATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSR 169
Query: 93 --CVCDEGYIGARCERVDL--FY------------LRGDRGQILVICLIAVMVVFIILVI 136
C C + G RC+ + FY L R + IA++VV I+ V+
Sbjct: 170 YLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVV 229
Query: 137 GVCTCCHPLRKRRKRKKK 154
C K +K++KK
Sbjct: 230 AYC-------KTKKQRKK 240
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 39.3 bits (90), Expect = 0.002
Identities = 27/86 (31%), Positives = 39/86 (45%), Gaps = 5/86 (5%)
Query: 69 CPKQYKHYCIKGRCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGDRGQILVICLIAV- 127
C + + YCI G C F + C C GY G RCE + L D + + I V
Sbjct: 51 CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLTSYAVDSYEKYIAIGIGVG 110
Query: 128 MVVFIILVIGVCTCCHPLRKRRKRKK 153
+++ LVI C +RKR ++ K
Sbjct: 111 LLLSGFLVIFYCY----IRKRYEKDK 132
>gi|20070380 neuregulin 4 [Homo sapiens]
Length = 115
Score = 38.5 bits (88), Expect = 0.003
Identities = 24/76 (31%), Positives = 35/76 (46%), Gaps = 6/76 (7%)
Query: 65 HFSRCPKQYKHYCIKGRCRFVVAE-QTPSCVCDEGYIGARCERVDLFYLRGDRGQIL--V 121
H C +K +C+ G +V+ +P C C E Y GARCE V +L G Q +
Sbjct: 5 HEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEV---FLPGSSIQTKSNL 61
Query: 122 ICLIAVMVVFIILVIG 137
+ V + L+IG
Sbjct: 62 FEAFVALAVLVTLIIG 77
>gi|236462773 neuregulin 1 isoform HRG-beta1d [Homo sapiens]
Length = 590
Score = 37.4 bits (85), Expect = 0.007
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 25/118 (21%)
Query: 55 ATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL- 109
AT+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 113 ATSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMA 172
Query: 110 -FY------------LRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY L R + IA++VV I+ V+ C K +K++KK
Sbjct: 173 SFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 223
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 37.4 bits (85), Expect = 0.007
Identities = 23/83 (27%), Positives = 38/83 (45%), Gaps = 10/83 (12%)
Query: 76 YCIKG-RCRFVVAEQTPSCVCDEGYIGARCERVDLFYLRGD----RGQILVICLIAVMVV 130
YC G C+ P C+C + G +CER + D R +++ L+ ++ +
Sbjct: 4397 YCYNGGTCQLDPETNVPVCLCSTNWSGTQCERPAPKSSKSDHISTRSIAIIVPLVLLVTL 4456
Query: 131 FIILVIGVCTCCHPLRKRRKRKK 153
LVIG+ C KR++R K
Sbjct: 4457 ITTLVIGLVLC-----KRKRRTK 4474
Score = 28.1 bits (61), Expect = 4.1
Identities = 10/31 (32%), Positives = 15/31 (48%)
Query: 75 HYCIKGRCRFVVAEQTPSCVCDEGYIGARCE 105
HYC+ + + + CVC Y G +CE
Sbjct: 4327 HYCVNSESCTIGDDGSVECVCPTRYEGPKCE 4357
>gi|236462348 neuregulin 1 isoform HRG-beta1b [Homo sapiens]
Length = 624
Score = 36.6 bits (83), Expect = 0.012
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 25/119 (21%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL 109
++T+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 146 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 205
Query: 110 --FY------------LRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY L R + IA++VV I+ V+ C K +K++KK
Sbjct: 206 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 257
>gi|116006955 neuregulin 1 isoform HRG-beta1 [Homo sapiens]
Length = 645
Score = 36.6 bits (83), Expect = 0.012
Identities = 31/119 (26%), Positives = 51/119 (42%), Gaps = 25/119 (21%)
Query: 54 AATTTQSKRKGHFSRCPKQYKHYCIK-GRCRFVVAEQTPS---CVCDEGYIGARCERVDL 109
++T+T + H +C ++ K +C+ G C V PS C C + G RC+ +
Sbjct: 167 SSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVM 226
Query: 110 --FY------------LRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKK 154
FY L R + IA++VV I+ V+ C K +K++KK
Sbjct: 227 ASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYC-------KTKKQRKK 278
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 36.2 bits (82), Expect = 0.015
Identities = 32/119 (26%), Positives = 48/119 (40%), Gaps = 28/119 (23%)
Query: 64 GHFSRCPKQYK-HYCIKGR--CRF---------VVAEQTPSCVCDEGYIGARCER----- 106
G+ +CP Q+ +C +GR C F +++ + SC C Y G RCE
Sbjct: 3969 GYVCKCPPQFSGKHCEQGRENCTFAPCLEGGTCILSPKGASCNCPHPYTGDRCEMEARGC 4028
Query: 107 ------VDLFYLRGDRGQILVICLIAVMVVFIILVIGVCTCCHPLRKRRKRKKKEEEME 159
V RGD GQ ++ + + II +G+ C RR + K ME
Sbjct: 4029 SEGHCLVTPEIQRGDWGQQELLIITVAVAFIIISTVGLLFYC-----RRCKSHKPVAME 4082
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 35.4 bits (80), Expect = 0.026
Identities = 14/30 (46%), Positives = 18/30 (60%)
Query: 79 KGRCRFVVAEQTPSCVCDEGYIGARCERVD 108
KG+C +E T SC C+E Y+G CE D
Sbjct: 322 KGKCTTKPSEATFSCTCEEQYVGTFCEEYD 351
Score = 30.8 bits (68), Expect = 0.64
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 13/60 (21%)
Query: 92 SCVCDEGYIGARCERVDLFYLRGDRGQ------------ILVICLIAVMVVFIILVIGVC 139
+C C G++GA CE + L + G + I+ +A +++ IIL++G+C
Sbjct: 604 NCHCPHGWVGANCE-IHLQWKSGHMAESLTNMPRHSLYIIIGALCVAFILMLIILIVGIC 662
Score = 30.4 bits (67), Expect = 0.84
Identities = 33/134 (24%), Positives = 46/134 (34%), Gaps = 33/134 (24%)
Query: 3 RAARCSGASSLPLLLALALGLVILHC---------------VVADGNSTRSPETNGLLCG 47
R A+ GA LP ALAL L++L + A G P NG +C
Sbjct: 4 RRAQAPGAQLLP---ALALLLLLLGAGPRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCT 60
Query: 48 DPEENCAATTTQSKRKGHFSRCPKQYK-------------HYCIKGRCRFVVAEQTPS-- 92
E + G+ CP + C G C + +
Sbjct: 61 SRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYL 120
Query: 93 CVCDEGYIGARCER 106
C+C+EGY G CE+
Sbjct: 121 CICNEGYEGPNCEQ 134
Score = 28.5 bits (62), Expect = 3.2
Identities = 13/29 (44%), Positives = 14/29 (48%), Gaps = 2/29 (6%)
Query: 77 CIKGRCRFVVAEQTPSCVCDEGYIGARCE 105
C G CR V C+CD GY G CE
Sbjct: 477 CAHGTCRSVGTSY--KCLCDPGYHGLYCE 503
Score = 27.7 bits (60), Expect = 5.4
Identities = 21/74 (28%), Positives = 29/74 (39%), Gaps = 5/74 (6%)
Query: 37 RSPETNGLLCGDP-EENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCR----FVVAEQTP 91
R P N C D E+ + T G+ + YCI CR + +
Sbjct: 355 RKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGF 414
Query: 92 SCVCDEGYIGARCE 105
+C C EGY G+ CE
Sbjct: 415 TCQCPEGYFGSACE 428
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,242,154
Number of Sequences: 37866
Number of extensions: 324931
Number of successful extensions: 2646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 98
Number of HSP's that attempted gapping in prelim test: 2202
Number of HSP's gapped (non-prelim): 542
length of query: 178
length of database: 18,247,518
effective HSP length: 96
effective length of query: 82
effective length of database: 14,612,382
effective search space: 1198215324
effective search space used: 1198215324
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 58 (26.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.