Search of human proteins with 45006951

Search of human proteins with 45006951

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45006951 dihydroorotate dehydrogenase precursor [Homo
sapiens]
         (395 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45006951 dihydroorotate dehydrogenase precursor [Homo sapiens]     775   0.0  
gi|119943098 dihydropyrimidine dehydrogenase isoform 1 [Homo sap...    57   4e-08
gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]          35   0.090
gi|54234014 hydroxyacid oxidase 2 [Homo sapiens]                       33   0.59 
gi|7705393 hydroxyacid oxidase 2 [Homo sapiens]                        33   0.59 
gi|11068137 hydroxyacid oxidase 1 [Homo sapiens]                       32   1.00 
gi|4507185 sepiapterin reductase [Homo sapiens]                        31   2.2  
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...    31   2.2  
gi|72534670 phospholipase A2-activating protein [Homo sapiens]         30   3.8  
gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]              30   5.0  
gi|4557235 acyl-Coenzyme A dehydrogenase, very long chain isofor...    29   6.5  
gi|76496475 acyl-Coenzyme A dehydrogenase, very long chain isofo...    29   6.5  
gi|19923821 dihydropyrimidinase-like 5 [Homo sapiens]                  29   6.5  
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo...    29   6.5  
gi|52694752 glycoprotein (transmembrane) nmb isoform a precursor...    29   8.5  
gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]            29   8.5  
gi|169205732 PREDICTED: hypothetical protein [Homo sapiens]            29   8.5  

>gi|45006951 dihydroorotate dehydrogenase precursor [Homo sapiens]
          Length = 395

 Score =  775 bits (2002), Expect = 0.0
 Identities = 395/395 (100%), Positives = 395/395 (100%)

Query: 1   MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR 60
           MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
Sbjct: 1   MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR 60

Query: 61  FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV 120
           FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
Sbjct: 61  FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV 120

Query: 121 TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN 180
           TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
Sbjct: 121 TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN 180

Query: 181 LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER 240
           LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
Sbjct: 181 LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER 240

Query: 241 DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET 300
           DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
Sbjct: 241 DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET 300

Query: 301 GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF 360
           GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
Sbjct: 301 GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF 360

Query: 361 WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR 395
           WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
Sbjct: 361 WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR 395


>gi|119943098 dihydropyrimidine dehydrogenase isoform 1 [Homo
           sapiens]
          Length = 1025

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 74/317 (23%), Positives = 135/317 (42%), Gaps = 28/317 (8%)

Query: 78  LEVRVLGHKFRNPVGIAAGFDKHGEA-VDGLYKMGFGFVEIGSVT-PKPQEGNPRPRVFR 135
           + V + G KF NP G+A+       + +   ++ G+GF    + +  K    N  PR+ R
Sbjct: 533 ISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIR 592

Query: 136 LPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYA 195
                 +      +   + ++  +  A   +     +   P  + +     S +  +   
Sbjct: 593 GTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTE 652

Query: 196 EGVRVLGPLADYLVVNVSSPNTAGLRSLQGKA-----ELRRLLTKVLQERDGLRRVHRPA 250
              +     AD L +N+S P+  G R + G A     EL R + +       +R+  +  
Sbjct: 653 LAKKSEDSGADALELNLSCPHGMGERGM-GLACGQDPELVRNICR------WVRQAVQIP 705

Query: 251 VLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQG----------ALRSET 300
              K+ P++T  D   IA   KE G +G+  TNT VS   GL+           A R+  
Sbjct: 706 FFAKLTPNVT--DIVSIARAAKEGGANGVTATNT-VSGLMGLKSDGTPWPAVGIAKRTTY 762

Query: 301 GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF 360
           GG+SG  +R ++ + +  +     G  PI+  GG+ S +  L+ + +GAS++Q+ +A+  
Sbjct: 763 GGVSGTAIRPIALRAVTSIARALPG-FPILATGGIDSAESGLQFLHSGASVLQVCSAIQN 821

Query: 361 WGPPVVGKVKRELEALL 377
               V+      L+ALL
Sbjct: 822 QDFTVIEDYCTGLKALL 838


>gi|33350932 cytoplasmic dynein 1 heavy chain 1 [Homo sapiens]
          Length = 4646

 Score = 35.4 bits (80), Expect = 0.090
 Identities = 37/160 (23%), Positives = 72/160 (45%), Gaps = 23/160 (14%)

Query: 151  HGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVV 210
            H L  + H      +K+++L E  + L V L K K +VD  E+    +R+    +  L V
Sbjct: 3175 HYLDFINHYANLFHEKRSELEEQQMHLNVGLRKIKETVDQVEELRRDLRI---KSQELEV 3231

Query: 211  NVSSPNTAGLRSL--QGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIA 268
              ++ N    + +  Q +AE ++++++ +QE     ++H+     ++  D     KED+ 
Sbjct: 3232 KNAAANDKLKKMVKDQQEAEKKKVMSQEIQE-----QLHKQQ---EVIADKQMSVKEDLD 3283

Query: 269  SV----------VKELGIDGLIVTNTTVSRPAGLQGALRS 298
             V          VK +    L+   +  + PA ++ AL S
Sbjct: 3284 KVEPAVIEAQNAVKSIKKQHLVEVRSMANPPAAVKLALES 3323


>gi|54234014 hydroxyacid oxidase 2 [Homo sapiens]
          Length = 351

 Score = 32.7 bits (73), Expect = 0.59
 Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 8/92 (8%)

Query: 292 LQGALRSETGGLSGKPLRDL--STQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGA 349
           +QG + S  GG   + L ++  S   + E+ A  +G++ +   GGV +G D L+ +  GA
Sbjct: 238 VQGIIVSNHGG---RQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGA 294

Query: 350 SLVQLYTALTFWGPPVVGK--VKRELEALLKE 379
             + L   +  WG    G+  VK  L  L  E
Sbjct: 295 KCIFLGRPI-LWGLACKGEHGVKEVLNILTNE 325


>gi|7705393 hydroxyacid oxidase 2 [Homo sapiens]
          Length = 351

 Score = 32.7 bits (73), Expect = 0.59
 Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 8/92 (8%)

Query: 292 LQGALRSETGGLSGKPLRDL--STQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGA 349
           +QG + S  GG   + L ++  S   + E+ A  +G++ +   GGV +G D L+ +  GA
Sbjct: 238 VQGIIVSNHGG---RQLDEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGA 294

Query: 350 SLVQLYTALTFWGPPVVGK--VKRELEALLKE 379
             + L   +  WG    G+  VK  L  L  E
Sbjct: 295 KCIFLGRPI-LWGLACKGEHGVKEVLNILTNE 325


>gi|11068137 hydroxyacid oxidase 1 [Homo sapiens]
          Length = 370

 Score = 32.0 bits (71), Expect = 1.00
 Identities = 28/93 (30%), Positives = 43/93 (46%), Gaps = 7/93 (7%)

Query: 291 GLQGALRSETGG--LSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAG 348
           GL G L S  G   L G P    +   + E+    +G+V +   GGV  G D L+ +  G
Sbjct: 251 GLNGILVSNHGARQLDGVPA---TIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALG 307

Query: 349 ASLVQLYTALTFWGPPVVG-KVKRELEALLKEQ 380
           A  V +   +  WG    G K  +++  +LKE+
Sbjct: 308 AKAVFVGRPIV-WGLAFQGEKGVQDVLEILKEE 339


>gi|4507185 sepiapterin reductase [Homo sapiens]
          Length = 261

 Score = 30.8 bits (68), Expect = 2.2
 Identities = 36/120 (30%), Positives = 49/120 (40%), Gaps = 25/120 (20%)

Query: 199 RVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPD 258
           R L PL    + ++ SP +  + S +    LR+L  ++  ER GLR V  PA       D
Sbjct: 21  RTLAPL----LASLLSPGSVLVLSARNDEALRQLEAELGAERSGLRVVRVPA-------D 69

Query: 259 LTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSG---KPLRDLSTQT 315
           L +           E G+  L+     + RP GLQ  L     G  G   K   DLS  T
Sbjct: 70  LGA-----------EAGLQQLLGALRELPRPKGLQRLLLINNAGSLGDVSKGFVDLSDST 118


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
           2 [Homo sapiens]
          Length = 1704

 Score = 30.8 bits (68), Expect = 2.2
 Identities = 20/62 (32%), Positives = 31/62 (50%), Gaps = 1/62 (1%)

Query: 134 FRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTE-DGLPLGVNLGKNKTSVDAAE 192
           F   +D A IN       G+S   HR R  +Q Q  L++   +P+  N+ K K + D ++
Sbjct: 32  FTTVKDCAAINDSLLQKIGISPTGHRRRILKQLQIILSKMQDIPIYANVHKTKKNDDPSK 91

Query: 193 DY 194
           DY
Sbjct: 92  DY 93


>gi|72534670 phospholipase A2-activating protein [Homo sapiens]
          Length = 795

 Score = 30.0 bits (66), Expect = 3.8
 Identities = 19/76 (25%), Positives = 35/76 (46%), Gaps = 4/76 (5%)

Query: 222 SLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIV 281
           +++GKA+   L++ +L+    L    R    + +A      D  +   + K LG+D  I 
Sbjct: 718 NIEGKAQCLSLISTILEVVQDLEATFR----LLVALGTLISDDSNAVQLAKSLGVDSQIK 773

Query: 282 TNTTVSRPAGLQGALR 297
             ++VS PA +    R
Sbjct: 774 KYSSVSEPAKVSECCR 789


>gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]
          Length = 636

 Score = 29.6 bits (65), Expect = 5.0
 Identities = 28/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)

Query: 165 QKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQ 224
           Q+QA +T   +P  V LG  +  V   E     +  +    D    ++       +  L+
Sbjct: 280 QQQASVTAGKVPEVVALGAAEKKVKMLEQQRSELLEVNKQWDQHFRSMKQQYEQKITELR 339

Query: 225 GK-AELRRLLTKVLQERDGLRR-VHRPAVLVKIAPDLTSQDKEDIASVVKEL 274
            K A+L++ +T +  ER+  +R   R  +L K   ++   DKE + +  KEL
Sbjct: 340 QKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKEL 391


>gi|4557235 acyl-Coenzyme A dehydrogenase, very long chain isoform 1
           precursor [Homo sapiens]
          Length = 655

 Score = 29.3 bits (64), Expect = 6.5
 Identities = 11/23 (47%), Positives = 16/23 (69%)

Query: 364 PVVGKVKRELEALLKEQGFGGVT 386
           P  G VK ++ A + E+GFGG+T
Sbjct: 270 PATGAVKEKITAFVVERGFGGIT 292


>gi|76496475 acyl-Coenzyme A dehydrogenase, very long chain isoform
           2 precursor [Homo sapiens]
          Length = 633

 Score = 29.3 bits (64), Expect = 6.5
 Identities = 11/23 (47%), Positives = 16/23 (69%)

Query: 364 PVVGKVKRELEALLKEQGFGGVT 386
           P  G VK ++ A + E+GFGG+T
Sbjct: 248 PATGAVKEKITAFVVERGFGGIT 270


>gi|19923821 dihydropyrimidinase-like 5 [Homo sapiens]
          Length = 564

 Score = 29.3 bits (64), Expect = 6.5
 Identities = 25/69 (36%), Positives = 33/69 (47%), Gaps = 12/69 (17%)

Query: 321 ALTQGRVPIIG---VGGVSSGQDALEKIRAGASL-----VQLYTALTFWGPPVVGKVKRE 372
           AL  G   IIG       +S  DA EK R  A         L+  +T+W P    KVK E
Sbjct: 89  ALVGGTTMIIGHVLPDKETSLVDAYEKCRGLADPKVCCDYALHVGITWWAP----KVKAE 144

Query: 373 LEALLKEQG 381
           +E L++E+G
Sbjct: 145 METLVREKG 153


>gi|112789555 ADAM metallopeptidase with thrombospondin type 1
           motif, 19 preproprotein [Homo sapiens]
          Length = 1207

 Score = 29.3 bits (64), Expect = 6.5
 Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 10/93 (10%)

Query: 151 HGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVV 210
           HG  ++E   + + ++  K  +  L +  N G++ TSVDAA        +L    D+ V 
Sbjct: 392 HGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAA--------ILITRKDFCVH 443

Query: 211 NVSSPNTAGLRSLQGKAELRRLLTKVLQERDGL 243
                +T G+  L G    +R    ++ E +GL
Sbjct: 444 KDEPCDTVGIAYLSGMCSEKRKC--IIAEDNGL 474


>gi|52694752 glycoprotein (transmembrane) nmb isoform a precursor
           [Homo sapiens]
          Length = 572

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 15/39 (38%), Positives = 22/39 (56%), Gaps = 1/39 (2%)

Query: 119 SVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVE 157
           S TP P   NP   + R+P++   INRYG     +++VE
Sbjct: 348 SNTPGPAGDNPL-ELSRIPDENCQINRYGHFQATITIVE 385


>gi|239750574 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1297

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%)

Query: 161  RARQQKQAKLTEDGLPLGVNLGKNKTSVDAA-EDYAEGVRVLGPLADYLVVNVSSPNTAG 219
            R+R++    L     P    LG+ +    A     A   R+ G   D +VV   + +  G
Sbjct: 943  RSRRRAAVALAGGAHPARAALGRRRGGGQAVGARAAHQARLAGGQVDQVVVAARAGDADG 1002

Query: 220  LR-------SLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDL 259
            +R       +L  + EL  LL ++   +DGL  V R   +V++ P L
Sbjct: 1003 VRGRRPRRLALTARPELEELLERLHGLQDGLVDVLRHHRVVRLHPQL 1049


>gi|169205732 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1297

 Score = 28.9 bits (63), Expect = 8.5
 Identities = 28/107 (26%), Positives = 46/107 (42%), Gaps = 8/107 (7%)

Query: 161  RARQQKQAKLTEDGLPLGVNLGKNKTSVDAA-EDYAEGVRVLGPLADYLVVNVSSPNTAG 219
            R+R++    L     P    LG+ +    A     A   R+ G   D +VV   + +  G
Sbjct: 943  RSRRRAAVALAGGAHPARAALGRRRGGGQAVGARAAHQARLAGGQVDQVVVAARAGDADG 1002

Query: 220  LR-------SLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDL 259
            +R       +L  + EL  LL ++   +DGL  V R   +V++ P L
Sbjct: 1003 VRGRRPRRLALTARPELEELLERLHGLQDGLVDVLRHHRVVRLHPQL 1049


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.138    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,573,040
Number of Sequences: 37866
Number of extensions: 648099
Number of successful extensions: 1385
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 1375
Number of HSP's gapped (non-prelim): 20
length of query: 395
length of database: 18,247,518
effective HSP length: 104
effective length of query: 291
effective length of database: 14,309,454
effective search space: 4164051114
effective search space used: 4164051114
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.