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Search of human proteins with 44917619
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44917619 kelch domain containing 10 [Homo sapiens]
(442 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44917619 kelch domain containing 10 [Homo sapiens] 941 0.0
gi|47717139 leucine-zipper-like transcription regulator 1 [Homo ... 99 8e-21
gi|16945972 kelch domain containing 3 [Homo sapiens] 85 1e-16
gi|26190616 kelch domain containing 1 [Homo sapiens] 81 2e-15
gi|7657301 kelch domain containing 2 [Homo sapiens] 80 4e-15
gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens] 72 8e-13
gi|7019405 host cell factor C2 [Homo sapiens] 65 9e-11
gi|98986457 host cell factor 1 [Homo sapiens] 65 2e-10
gi|21314675 kelch domain containing 4 [Homo sapiens] 65 2e-10
gi|148664209 kelch-like 10 [Homo sapiens] 64 3e-10
gi|46410931 attractin-like 1 [Homo sapiens] 61 2e-09
gi|40018614 DRE1 protein [Homo sapiens] 60 4e-09
gi|45643138 kelch-like 13 [Homo sapiens] 55 1e-07
gi|62955044 F-box protein 42 [Homo sapiens] 54 2e-07
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 53 6e-07
gi|11056006 kelch-like 12 [Homo sapiens] 52 8e-07
gi|24308181 kelch-like 9 [Homo sapiens] 52 8e-07
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 51 2e-06
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 51 2e-06
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 50 4e-06
gi|88196794 kelch-like 35 [Homo sapiens] 49 7e-06
gi|148664248 kelch domain containing 6 [Homo sapiens] 49 7e-06
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 49 9e-06
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 49 9e-06
gi|14780904 kelch-like 1 protein [Homo sapiens] 49 1e-05
gi|158508542 kelch-like 33 [Homo sapiens] 48 2e-05
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 48 2e-05
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 48 2e-05
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 48 2e-05
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 48 2e-05
>gi|44917619 kelch domain containing 10 [Homo sapiens]
Length = 442
Score = 941 bits (2432), Expect = 0.0
Identities = 442/442 (100%), Positives = 442/442 (100%)
Query: 1 MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKI 60
MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKI
Sbjct: 1 MSAAQGWDRNRRRGGGAAGAGGGGSGAGGGSGGSGGRGTGQLNRFVQLSGRPHLPGKKKI 60
Query: 61 RWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP 120
RWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP
Sbjct: 61 RWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGP 120
Query: 121 DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESN 180
DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESN
Sbjct: 121 DNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESN 180
Query: 181 GNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLN 240
GNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLN
Sbjct: 181 GNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLN 240
Query: 241 TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWE 300
TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWE
Sbjct: 241 TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWE 300
Query: 301 EIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM 360
EIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM
Sbjct: 301 EIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATM 360
Query: 361 PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNL 420
PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNL
Sbjct: 361 PEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNL 420
Query: 421 ANLSRTQLLHLGLTQGLIERLK 442
ANLSRTQLLHLGLTQGLIERLK
Sbjct: 421 ANLSRTQLLHLGLTQGLIERLK 442
>gi|47717139 leucine-zipper-like transcription regulator 1 [Homo
sapiens]
Length = 840
Score = 99.0 bits (245), Expect = 8e-21
Identities = 75/319 (23%), Positives = 141/319 (44%), Gaps = 23/319 (7%)
Query: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTD 147
PP R H V ++++VFGGY D + N++ +L+ Y FATG W + +
Sbjct: 114 PPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKN-----DLFEYKFATGQWTEWKIE 168
Query: 148 GYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR---WALLSCRGKKP 204
G +P ++ ++ + L +F G G + ND+ ++ + W ++ G+ P
Sbjct: 169 GRLPVARSAHGATVYSDKLWIFAGYD---GNARLNDMWTIGLQDRELTCWEEVAQSGEIP 225
Query: 205 SRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL---SCDLPEERY 261
+A+ ++VF G +G + +L + + + WT++ +L S P+ RY
Sbjct: 226 PSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRY 285
Query: 262 RHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSC 321
H + + +Y+ GG T N++H Y+++ WE + ++G +C
Sbjct: 286 GHTMVAFDRHLYVFGGAADNTL--PNELHCYDVDFQTWEVVQPSSDSEVGGAEVPE-RAC 342
Query: 322 VQIKNDVFICGGYNGEVILGDIWKLNLQTF---QWVKLPATMPEPVYFHCAAVTPAGCMY 378
+ G D++ L+ T Q + + +P FH AAV + MY
Sbjct: 343 ASEEVPTLTYEERVGFKKSRDVFGLDFGTTSAKQPTQPASELPSGRLFHAAAVI-SDAMY 401
Query: 379 IHGGVVNIHENKRTGSLFK 397
I GG V+ N R+G +++
Sbjct: 402 IFGGTVD--NNIRSGEMYR 418
Score = 63.5 bits (153), Expect = 4e-10
Identities = 55/228 (24%), Positives = 93/228 (40%), Gaps = 36/228 (15%)
Query: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
D ++ + ++V + + + VFGG G++ ND+ +VK W G P+
Sbjct: 61 DEFVGARRSKHTVVAYKDAIYVFGGDN---GKTMLNDLLRFDVKDCSWCRAFTTGTPPAP 117
Query: 207 IYGQAMAIINGSLYVFGGTTGYIYS-------TDLHKLDLNTREWTQLKPNNLSCDLPEE 259
Y + + S++VFGG TG IYS DL + T +WT+ K + LP
Sbjct: 118 RYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWK---IEGRLPVA 174
Query: 260 RYRHEIAHDGQRIYILGG-------GTSWTAYSLNKIHAYNLETNAWEEIATK---PHEK 309
R H +++I G WT I + E WEE+A P
Sbjct: 175 RSAHGATVYSDKLWIFAGYDGNARLNDMWT------IGLQDRELTCWEEVAQSGEIPPSC 228
Query: 310 IGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLP 357
FP A ++ +F+ G +G I ++++ + W ++P
Sbjct: 229 CNFPVA-------VCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIP 269
Score = 43.5 bits (101), Expect = 4e-04
Identities = 29/93 (31%), Positives = 48/93 (51%), Gaps = 8/93 (8%)
Query: 312 FPAARRC-HSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVK--LPATMPEPVYFHC 368
F ARR H+ V K+ +++ GG NG+ +L D+ + +++ W + T P P Y H
Sbjct: 63 FVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHH- 121
Query: 369 AAVTPAGCMYIHGGVV-NIHEN---KRTGSLFK 397
+AV M++ GG +I+ N K LF+
Sbjct: 122 SAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFE 154
>gi|16945972 kelch domain containing 3 [Homo sapiens]
Length = 382
Score = 84.7 bits (208), Expect = 1e-16
Identities = 76/291 (26%), Positives = 113/291 (38%), Gaps = 45/291 (15%)
Query: 90 PARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGV---WHQM-- 144
P R H VA +Y FGGY EDY R++ H V W ++
Sbjct: 12 PRRVNHAAVAVGHRVYSFGGY---------CSGEDYETLRQI-DVHIFNAVSLRWTKLPP 61
Query: 145 ------GTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLS 198
G +P S VL + +L++GG G N ++ +V +W
Sbjct: 62 VKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGAC--NVLYAFDVNTHKWFTPR 119
Query: 199 CRGKKPSRIYGQAMAIINGSLYVFGG--TTGYIYSTDLHKLDLNTREWTQLKPNNLSCDL 256
G P G + ++ +Y+FGG +S D+HKLD +T WT +
Sbjct: 120 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKG----- 174
Query: 257 PEERYR--HEIAHDGQRIYILGGGT-------SWTAYSLNKIHAYNLETNAWEEIATKPH 307
R+R H G +Y+ GG S N+I ++ T AW + P
Sbjct: 175 SPARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTP- 233
Query: 308 EKIGFPAARRCHSCVQIKNDVFICGGYNGEV--ILGDIWKLNLQTFQWVKL 356
P RR HS +++I GGYN + D+WK N +F W K+
Sbjct: 234 ---VLPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKI 281
Score = 64.7 bits (156), Expect = 2e-10
Identities = 72/274 (26%), Positives = 115/274 (41%), Gaps = 38/274 (13%)
Query: 163 GNNLLVFGG--TGIPFGESNGNDVHVCNVKYKRWALL-----SCRGKKPS---RIYGQAM 212
G+ + FGG +G + DVH+ N RW L + RG+ P YG +
Sbjct: 23 GHRVYSFGGYCSGEDYETLRQIDVHIFNAVSLRWTKLPPVKSAIRGQAPVVPYMRYGHST 82
Query: 213 AIINGSLYVFGGTTGYIYSTD-LHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQR 271
+I+ ++ ++GG + + L+ D+NT +W + +S +P R H G+
Sbjct: 83 VLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR---VSGTVPGARDGHSACVLGKI 139
Query: 272 IYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAA-RRCHSCVQIKNDVFI 330
+YI GG N IH + T W I TK G PA R HS + + +++
Sbjct: 140 MYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTK-----GSPARWRDFHSATMLGSHMYV 194
Query: 331 CGG---------YNGEVILGDIWKLNLQTFQWVKLPAT--MPEPVYFHCAAVTPAGCMYI 379
GG N E+ I + +T W+ P T +PE H +A G +YI
Sbjct: 195 FGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPTPVLPEGRRSH-SAFGYNGELYI 253
Query: 380 HGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKL 413
GG N N+ L+K + + W+K+
Sbjct: 254 FGG-YNARLNRHFHDLWKF-----NPVSFTWKKI 281
Score = 62.0 bits (149), Expect = 1e-09
Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 32/263 (12%)
Query: 83 LRGHRP--PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGV 140
+RG P P R GH V + + ++GG N ++ G N L+ + T
Sbjct: 66 IRGQAPVVPYMRYGHSTVLIDDTVLLWGGRN----DTEGACNV-------LYAFDVNTHK 114
Query: 141 WHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR 200
W G +P S + G + +FGG + ND+H + W L+ +
Sbjct: 115 WFTPRVSGTVPGARDGHSACVLGKIMYIFGGYEQQ-ADCFSNDIHKLDTSTMTWTLICTK 173
Query: 201 GKKPSRIYGQAMAIINGS-LYVFGG---------TTGYIYSTDLHKLDLNTREWTQLKPN 250
G P+R A + GS +YVFGG + IY + D T W P
Sbjct: 174 GS-PARWRDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTRTEAWLDCPPT 232
Query: 251 NLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKI 310
+ LPE R H +YI GG + + + +N + W++I +P K
Sbjct: 233 PV---LPEGRRSHSAFGYNGELYIFGGYNARLNRHFHDLWKFNPVSFTWKKI--EPKGKG 287
Query: 311 GFPAARRCHSCVQIKNDVFICGG 333
P R+C C + + + + GG
Sbjct: 288 PCPRRRQC--CCIVGDKIVLFGG 308
Score = 42.7 bits (99), Expect = 7e-04
Identities = 24/95 (25%), Positives = 40/95 (42%), Gaps = 10/95 (10%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
P R H N LY+FGGYN + F +LW+++ + W ++ G
Sbjct: 236 PEGRRSHSAFGYNGELYIFGGYNARLNRH----------FHDLWKFNPVSFTWKKIEPKG 285
Query: 149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESNGND 183
P + G+ +++FGGT E G++
Sbjct: 286 KGPCPRRRQCCCIVGDKIVLFGGTSPSPEEGLGDE 320
Score = 38.5 bits (88), Expect = 0.012
Identities = 43/190 (22%), Positives = 70/190 (36%), Gaps = 17/190 (8%)
Query: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWR-YHFATGVWHQMGT 146
P R H +++YVFGG + GP + + ++ R + T W
Sbjct: 176 PARWRDFHSATMLGSHMYVFGGRADRF----GPFHSNNEIYCNRIRVFDTRTEAWLDCPP 231
Query: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
+P S S + L +FGG + +D+ N W + +GK P
Sbjct: 232 TPVLPEGRRSHSAFGYNGELYIFGGYNARLNR-HFHDLWKFNPVSFTWKKIEPKGKGPCP 290
Query: 207 IYGQAMAIINGSLYVFGGTT-----------GYIYSTDLHKLDLNTREWTQLKPNNLSCD 255
Q I+ + +FGGT+ I +DLH LD + T K + +
Sbjct: 291 RRRQCCCIVGDKIVLFGGTSPSPEEGLGDEFDLIDHSDLHILDFSPSLKTLCKLAVIQYN 350
Query: 256 LPEERYRHEI 265
L + H+I
Sbjct: 351 LDQSCLPHDI 360
>gi|26190616 kelch domain containing 1 [Homo sapiens]
Length = 406
Score = 81.3 bits (199), Expect = 2e-15
Identities = 85/323 (26%), Positives = 124/323 (38%), Gaps = 50/323 (15%)
Query: 92 RSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMP 151
RSGH V D LYV+GGY DNE Y E+W Y +G+W +G +P
Sbjct: 13 RSGHCAVVDGNFLYVWGGY------VSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELP 66
Query: 152 RELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVK-----YKRWALLSCRGKKPSR 206
++ L +FGG + N ++ N++ Y + G+ P+
Sbjct: 67 ASMSGSCGACINGKLYIFGGYD---DKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTP 123
Query: 207 IYGQAMAIINGSLYVFGG----------------------TTGYIYSTDLHKLDLNTREW 244
+ + L FGG + + D+H D T+ W
Sbjct: 124 RDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTKTQTW 183
Query: 245 TQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIAT 304
Q P P+ R H A G + YI GG T +N +H NL+T W T
Sbjct: 184 FQ--PEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQT--RMNDLHYLNLDTWTWSGRIT 239
Query: 305 KPHEKIGFPAARRCHSCVQIKND-VFICGGYNGEVI-LGDIWKLNLQTFQW---VKLPAT 359
E P R H+ I +D +F+CGG + + I L D W N+ T W LP T
Sbjct: 240 INGES---PKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPKT 296
Query: 360 MPEPVYFHCAAVTPAGCMYIHGG 382
P +H A + + + GG
Sbjct: 297 RPR--LWHTACLGKENEIMVFGG 317
Score = 66.2 bits (160), Expect = 6e-11
Identities = 67/281 (23%), Positives = 113/281 (40%), Gaps = 37/281 (13%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQM-GTD 147
P + SG N LY+FGG YD+ G + L+ R T +W ++ +
Sbjct: 66 PASMSGSCGACINGKLYIFGG----YDDKGYSNR----LYFVNLRTRDETYIWEKITDFE 117
Query: 148 GYMPRELASMSLVLHGNNLLVFGGTGIP--------FGESNG-----------NDVHVCN 188
G P +S ++ + L+ FGG G F + NDVH+ +
Sbjct: 118 GQPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFD 177
Query: 189 VKYKRWALLSCRGKKPSR-IYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQL 247
K + W +G P + A++ Y+FGG DLH L+L+T WT
Sbjct: 178 TKTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDT--WTWS 235
Query: 248 KPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPH 307
++ + P+ R H + L GG S L+ +N+ TN W+++ P
Sbjct: 236 GRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQLTHLPK 295
Query: 308 EKIGFPAARRCH-SCVQIKNDVFICGGYNGEVILGDIWKLN 347
+ R H +C+ +N++ + GG +++ D N
Sbjct: 296 TR-----PRLWHTACLGKENEIMVFGGSKDDLLALDTGHCN 331
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/261 (24%), Positives = 107/261 (40%), Gaps = 49/261 (18%)
Query: 160 VLHGNNLLVFGGTGIPFGESNGNDVHVCN-------VKYKRWALLSCRGKKPSRIYGQAM 212
V+ GN L V+GG + N+V++ N + W + G+ P+ + G
Sbjct: 19 VVDGNFLYVWGG----YVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCG 74
Query: 213 AIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQL-------------KPNNLSCDLPEE 259
A ING LY+FGG YS L+ ++L TR+ T + + LSC + ++
Sbjct: 75 ACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKITDFEGQPPTPRDKLSCWVYKD 134
Query: 260 RY---------RHEIAHDGQRIYILGGGTSWTAYSL----NKIHAYNLETNAWEEIATKP 306
R RH D ++ SW N +H ++ +T W +P
Sbjct: 135 RLIYFGGYGCRRHSELQDCFDVH----DASWEEQIFWGWHNDVHIFDTKTQTW----FQP 186
Query: 307 HEKIGF-PAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW---VKLPATMPE 362
K G P R H+C + N +I GG + + D+ LNL T+ W + + P+
Sbjct: 187 EIKGGVPPQPRAAHTCAVLGNKGYIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPK 246
Query: 363 PVYFHCAAVTPAGCMYIHGGV 383
+H +++ GG+
Sbjct: 247 HRSWHTLTPIADDKLFLCGGL 267
Score = 35.0 bits (79), Expect = 0.14
Identities = 56/260 (21%), Positives = 101/260 (38%), Gaps = 36/260 (13%)
Query: 87 RPPPARSGHRCVADNTNLYVFGGYNP----------DYDESGGPDNEDYPLFRELWRYHF 136
+PP R C L FGGY D ++ + + ++ +
Sbjct: 119 QPPTPRDKLSCWVYKDRLIYFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDT 178
Query: 137 ATGVWHQMGTDGYM-PRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWA 195
T W Q G + P+ A+ + + GN +FGG + ++ ND+H N+ W+
Sbjct: 179 KTQTWFQPEIKGGVPPQPRAAHTCAVLGNKGYIFGGRVL---QTRMNDLHYLNLDTWTWS 235
Query: 196 -LLSCRGKKPS-RIYGQAMAIINGSLYVFGG-TTGYIYSTDLHKLDLNTREWTQLKPNNL 252
++ G+ P R + I + L++ GG + I +D ++ T W QL
Sbjct: 236 GRITINGESPKHRSWHTLTPIADDKLFLCGGLSADNIPLSDGWIHNVTTNCWKQL----- 290
Query: 253 SCDLPEERYR--HEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKI 310
LP+ R R H + ++ GG+ +L+ H +L T+P+ +
Sbjct: 291 -THLPKTRPRLWHTACLGKENEIMVFGGSKDDLLALDTGHCNDLLI-----FQTQPYSLL 344
Query: 311 GFPAARRCHSCVQIKNDVFI 330
R C C+ KN + +
Sbjct: 345 -----RSCLDCIG-KNSIML 358
Score = 31.6 bits (70), Expect = 1.5
Identities = 28/108 (25%), Positives = 48/108 (44%), Gaps = 14/108 (12%)
Query: 258 EERYRHEIAHDGQRIYILGGGTSWTAYSL----NKIHAYNLETNAWEEIATKPHEKIGFP 313
EER H DG +Y+ GG S + ++I Y++++ W + H G
Sbjct: 11 EERSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLW-----RMHLMEGEL 65
Query: 314 AARRCHSC-VQIKNDVFICGGYNGEVILGDIWKLNL----QTFQWVKL 356
A SC I ++I GGY+ + ++ +NL +T+ W K+
Sbjct: 66 PASMSGSCGACINGKLYIFGGYDDKGYSNRLYFVNLRTRDETYIWEKI 113
>gi|7657301 kelch domain containing 2 [Homo sapiens]
Length = 406
Score = 80.1 bits (196), Expect = 4e-15
Identities = 73/301 (24%), Positives = 119/301 (39%), Gaps = 50/301 (16%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRE-LWRYHFATGVWHQMGTD 147
P RSGH V+D +++V+GGY + D+ L RE LW Y+ TG W ++ T+
Sbjct: 29 PAERSGHVAVSDGRHMFVWGGYKSNQVRG----LYDFYLPREELWIYNMETGRWKKINTE 84
Query: 148 GYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYK----RWALLSCRGKK 203
G +P ++ V L +FGG N N ++ + + +W + C+G
Sbjct: 85 GDVPPSMSGSCAVCVDRVLYLFGGH---HSRGNTNKFYMLDSRSTDRVLQWERIDCQGIP 141
Query: 204 PSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRH 263
PS + + L FGG GY LPE++
Sbjct: 142 PSSKDKLGVWVYKNKLIFFGGY-GY---------------------------LPEDKVLG 173
Query: 264 EIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQ 323
D + W + +H + ET W + T P+ R H+C
Sbjct: 174 TFEFDETSFWNSSHPRGWNDH----VHILDTETFTWSQPITTGKA----PSPRAAHACAT 225
Query: 324 IKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGC--MYIHG 381
+ N F+ GG + + D+ LNL T++W +L PV ++TP +++ G
Sbjct: 226 VGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFG 285
Query: 382 G 382
G
Sbjct: 286 G 286
Score = 68.6 bits (166), Expect = 1e-11
Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 37/266 (13%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
PP+ SG V + LY+FGG++ S G N+ Y L R W ++ G
Sbjct: 88 PPSMSGSCAVCVDRVLYLFGGHH-----SRGNTNKFYMLDS---RSTDRVLQWERIDCQG 139
Query: 149 YMPRELASMSLVLHGNNLLVFGGTG----------IPFGESN----------GNDVHVCN 188
P + + ++ N L+ FGG G F E++ + VH+ +
Sbjct: 140 IPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDETSFWNSSHPRGWNDHVHILD 199
Query: 189 VKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLK 248
+ W+ GK PS A A + +VFGG DLH L+L+T EW +L
Sbjct: 200 TETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDARMNDLHYLNLDTWEWNELI 259
Query: 249 PNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHE 308
P + P R H + L GG + L+ Y + N W + E
Sbjct: 260 PQGI---CPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTYCISKNEWIQFNHPYTE 316
Query: 309 KIGFPAARRCH-SCVQIKNDVFICGG 333
K R H +C + +V + GG
Sbjct: 317 K-----PRLWHTACASDEGEVIVFGG 337
Score = 30.4 bits (67), Expect = 3.4
Identities = 30/139 (21%), Positives = 51/139 (36%), Gaps = 15/139 (10%)
Query: 87 RPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGT 146
+ P R+ H C +VFGG D +L + T W+++
Sbjct: 213 KAPSPRAAHACATVGNRGFVFGGRYRD------------ARMNDLHYLNLDTWEWNELIP 260
Query: 147 DGYMPRELASMSLV-LHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPS 205
G P + SL + ++L +FG G + +D + W + +
Sbjct: 261 QGICPVGRSWHSLTPVSSDHLFLFG--GFTTDKQPLSDAWTYCISKNEWIQFNHPYTEKP 318
Query: 206 RIYGQAMAIINGSLYVFGG 224
R++ A A G + VFGG
Sbjct: 319 RLWHTACASDEGEVIVFGG 337
>gi|33695109 Rab9 effector protein with kelch motifs [Homo sapiens]
Length = 372
Score = 72.4 bits (176), Expect = 8e-13
Identities = 74/299 (24%), Positives = 114/299 (38%), Gaps = 38/299 (12%)
Query: 89 PPARSGHRCV-------ADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVW 141
P AR GH C A +++ GG NP+ F ++ W
Sbjct: 28 PCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRS------------FSDVHTMDLGKHQW 75
Query: 142 HQMGTDGYMPR-ELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR 200
G +PR E AS + + VFGG N N + V N + + W
Sbjct: 76 DLDTCKGLLPRYEHASFIPSCTPDRIWVFGGAN---QSGNRNCLQVLNPETRTWTTPEVT 132
Query: 201 GKKPS-RIYGQAMAIINGSLYVFGGT---TGYIYSTDLHKLDLNTREWTQLKPNNLSCDL 256
PS R + + A I LYVFGG + T LH D NT W+Q P L +
Sbjct: 133 SPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQ--PETLG-NP 189
Query: 257 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAAR 316
P R+ H + G +++I GG Y + +H ++ W+++ + PA
Sbjct: 190 PSPRHGHVMVAAGTKLFIHGGLAGDRFY--DDLHCIDISDMKWQKL----NPTGAAPAGC 243
Query: 317 RCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW--VKLPATMPEPVYFHCAAVTP 373
HS V + V+I GG L +++ + + W +K +P H + P
Sbjct: 244 AAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTLLPPGRLDHSMCIIP 302
Score = 61.6 bits (148), Expect = 1e-09
Identities = 54/207 (26%), Positives = 85/207 (41%), Gaps = 13/207 (6%)
Query: 182 NDVHVCNVKYKRWALLSCRGKKPSRIYGQAM-AIINGSLYVFGGTTGYIYSTDLHKLDLN 240
+DVH ++ +W L +C+G P + + + ++VFGG L L+
Sbjct: 63 SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIWVFGGANQSGNRNCLQVLNPE 122
Query: 241 TREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTA-YSLNKIHAYNLETNAW 299
TR WT P S + A G ++Y+ GGG K+H ++ T W
Sbjct: 123 TRTWTT--PEVTSPPPSPRTFHTSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLTW 180
Query: 300 EEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPAT 359
+ T + P+ R H V +FI GG G+ D+ +++ +W KL T
Sbjct: 181 SQPETLGNP----PSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPT 236
Query: 360 MPEPVYFHCA---AVTPAGCMYIHGGV 383
P CA AV +YI GG+
Sbjct: 237 GAAPA--GCAAHSAVAMGKHVYIFGGM 261
Score = 52.8 bits (125), Expect = 6e-07
Identities = 48/179 (26%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 88 PPPARSGHRCVADNTN-LYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGT 146
PP R+ H A N LYVFGG E G +D +L + T W Q T
Sbjct: 135 PPSPRTFHTSSAAIGNQLYVFGG-----GERGAQPVQD----TKLHVFDANTLTWSQPET 185
Query: 147 DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSR 206
G P +V G L + GG G+ +D+H ++ +W L+ G P+
Sbjct: 186 LGNPPSPRHGHVMVAAGTKLFIHGGLA---GDRFYDDLHCIDISDMKWQKLNPTGAAPAG 242
Query: 207 IYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEI 265
+ + +Y+FGG T +++ + WT LK + L LP R H +
Sbjct: 243 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLLKFDTL---LPPGRLDHSM 298
Score = 45.8 bits (107), Expect = 8e-05
Identities = 59/237 (24%), Positives = 90/237 (37%), Gaps = 38/237 (16%)
Query: 194 WALLSCRGKKPSRIYGQAMAII-------NGSLYVFGGTTGYIYSTDLHKLDLNTREWTQ 246
W L+ G P G + + + G +++ GG +D+H +DL +W
Sbjct: 18 WYTLTVPGDSPCARVGHSCSYLPPVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDL 77
Query: 247 LKPNNLSCDLPEERYRHEI---AHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
L LP RY H + RI++ GG + + N + N ET W
Sbjct: 78 DTCKGL---LP--RYEHASFIPSCTPDRIWVFGGANQ--SGNRNCLQVLNPETRTW---- 126
Query: 304 TKPHEKIGFPAARRCH-SCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPE 362
T P P+ R H S I N +++ GG GE + L F L + PE
Sbjct: 127 TTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG--GERGAQPVQDTKLHVFDANTLTWSQPE 184
Query: 363 -----PVYFHCAAVTPAGC-MYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKL 413
P H + AG ++IHGG+ G F L + ++ W+KL
Sbjct: 185 TLGNPPSPRHGHVMVAAGTKLFIHGGL--------AGDRFYDDLHCIDISDMKWQKL 233
>gi|7019405 host cell factor C2 [Homo sapiens]
Length = 792
Score = 65.5 bits (158), Expect = 9e-11
Identities = 81/328 (24%), Positives = 123/328 (37%), Gaps = 74/328 (22%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
P AR GHR VA + +FGG N + EL Y+ AT W G
Sbjct: 20 PRARHGHRAVAIRELMIIFGGGNEGIAD-------------ELHVYNTATNQWFLPAVRG 66
Query: 149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR------GK 202
+P A+ V G +LVFGG + +G + N+++ ++ RW + G
Sbjct: 67 DIPPGCAAHGFVCDGTRILVFGGM-VEYGRYS-NELY--ELQASRWLWKKVKPHPPPSGL 122
Query: 203 KPSRIYGQAMAIINGSLYVFGGTTGYI---------YSTDLHKLDLNTRE----WTQLKP 249
P G + ++ Y+FGG Y D ++L+L W+
Sbjct: 123 PPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPVT 182
Query: 250 NNLSCDLPEERYRHEIA------HDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
+ +P R H ++Y+ GG L+ + +LET +W
Sbjct: 183 KGV---VPSPRESHTAVIYCKKDSGSPKMYVFGG---MCGARLDDLWQLDLETMSW---- 232
Query: 304 TKPHEKIGFPAARRCHSCVQIKNDVFICGGY------NGEVILGDI-WK-------LNLQ 349
+KP K P R H+ I N ++I GG+ N E D W+ LNL
Sbjct: 233 SKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLD 292
Query: 350 TFQWVKLPA--------TMPEPVYFHCA 369
T +W L + + P P HCA
Sbjct: 293 TTEWTTLVSDSQEDKKNSRPRPRAGHCA 320
Score = 40.8 bits (94), Expect = 0.002
Identities = 52/215 (24%), Positives = 78/215 (36%), Gaps = 30/215 (13%)
Query: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGV--WHQMG 145
PP R GH Y+FGG + ++S F EL H +GV W
Sbjct: 123 PPCPRLGHSFSLYGNKCYLFGGLANESEDSNNNVPRYLNDFYELELQH-GSGVVGWSIPV 181
Query: 146 TDGYMPRELASMSLVLH------GNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSC 199
T G +P S + V++ + VFGG + +D+ +++ W+
Sbjct: 182 TKGVVPSPRESHTAVIYCKKDSGSPKMYVFGG----MCGARLDDLWQLDLETMSWSKPET 237
Query: 200 RGKKPSRIYGQAMAIINGSLYVFGGTT---GYIYSTDLHK-----------LDLNTREWT 245
+G P ++I +Y+FGG G T H L+L+T EWT
Sbjct: 238 KGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNLDTTEWT 297
Query: 246 QL---KPNNLSCDLPEERYRHEIAHDGQRIYILGG 277
L + P R H G R+Y G
Sbjct: 298 TLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSG 332
Score = 37.4 bits (85), Expect = 0.027
Identities = 45/165 (27%), Positives = 60/165 (36%), Gaps = 40/165 (24%)
Query: 89 PPARSGHRCV------ADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWH 142
P R H V + + +YVFGG G +D LW+ T W
Sbjct: 187 PSPRESHTAVIYCKKDSGSPKMYVFGGMC-------GARLDD------LWQLDLETMSWS 233
Query: 143 QMGTDGY--MPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVC-----------NV 189
+ T G +PR L + S++ GN + +FGG GE+ H C N+
Sbjct: 234 KPETKGTVPLPRSLHTASVI--GNKMYIFGGWVPHKGENTETSPHDCEWRCTSSFSYLNL 291
Query: 190 KYKRWALL---SCRGKKPSR---IYGQAMAIINGSLYVFGGTTGY 228
W L S KK SR G I LY + G GY
Sbjct: 292 DTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYFWSGRDGY 336
>gi|98986457 host cell factor 1 [Homo sapiens]
Length = 2035
Score = 64.7 bits (156), Expect = 2e-10
Identities = 80/321 (24%), Positives = 118/321 (36%), Gaps = 63/321 (19%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
P R GHR VA + VFGG N + EL Y+ AT W G
Sbjct: 30 PRPRHGHRAVAIKELIVVFGGGNEG-------------IVDELHVYNTATNQWFIPAVRG 76
Query: 149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCR----GKKP 204
+P A+ V G LLVFGG + +G+ + ND++ W L + G P
Sbjct: 77 DIPPGCAAYGFVCDGTRLLVFGGM-VEYGKYS-NDLYELQASRWEWKRLKAKTPKNGPPP 134
Query: 205 SRIYGQAMAIINGSLYVFGGTTGYI---------YSTDLHKLDLNTREWTQLKPNNLSCD 255
G + +++ Y+FGG Y DL+ L+L ++
Sbjct: 135 CPRLGHSFSLVGNKCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVAWDIPITYG 194
Query: 256 -LPEERYRH------EIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHE 308
LP R H E + ++ I GG + L + +++T W KP
Sbjct: 195 VLPPPRESHTAVVYTEKDNKKSKLVIYGG---MSGCRLGDLWTLDIDTLTW----NKPSL 247
Query: 309 KIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDI--------WK-------LNLQTFQW 353
P R HS I N +++ GG+ +++ D+ WK LNL T W
Sbjct: 248 SGVAPLPRSLHSATTIGNKMYVFGGW-VPLVMDDVKVATHEKEWKCTNTLACLNLDTMAW 306
Query: 354 V-----KLPATMPEPVYFHCA 369
L +P HCA
Sbjct: 307 ETILMDTLEDNIPRARAGHCA 327
Score = 42.0 bits (97), Expect = 0.001
Identities = 64/301 (21%), Positives = 102/301 (33%), Gaps = 46/301 (15%)
Query: 88 PPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATG----VWHQ 143
PP R GH Y+FGG D ++ P N +L+ G W
Sbjct: 133 PPCPRLGHSFSLVGNKCYLFGGLANDSED---PKNNIPRYLNDLYILELRPGSGVVAWDI 189
Query: 144 MGTDGYMPRELASMSLVLH------GNNLLVFGG-TGIPFGESNGNDVHVCNVKYKRWAL 196
T G +P S + V++ + L+++GG +G G D+ ++ W
Sbjct: 190 PITYGVLPPPRESHTAVVYTEKDNKKSKLVIYGGMSGCRLG-----DLWTLDIDTLTWNK 244
Query: 197 LSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIY--------------STDLHKLDLNTR 242
S G P + I +YVFGG + + L L+L+T
Sbjct: 245 PSLSGVAPLPRSLHSATTIGNKMYVFGGWVPLVMDDVKVATHEKEWKCTNTLACLNLDTM 304
Query: 243 EWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEI 302
W + + L ++P R H R+YI G + N++ +L W
Sbjct: 305 AWETILMDTLEDNIPRARAGHCAVAINTRLYIWSGRDGYRKAWNNQVCCKDL----WYLE 360
Query: 303 ATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPE 362
KP R + +++ G V D + L LQ + AT
Sbjct: 361 TEKPPPPARVQLVRANTNSLEVS---------WGAVATADSYLLQLQKYDIPATAATATS 411
Query: 363 P 363
P
Sbjct: 412 P 412
>gi|21314675 kelch domain containing 4 [Homo sapiens]
Length = 520
Score = 64.7 bits (156), Expect = 2e-10
Identities = 63/242 (26%), Positives = 101/242 (41%), Gaps = 40/242 (16%)
Query: 88 PPPARSGHRCVA---DNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQM 144
PPP R H+ V L+VFGG E P+ E + +++LW H AT W Q+
Sbjct: 115 PPPRRCAHQAVVVPQGGGQLWVFGG------EFASPNGEQFYHYKDLWVLHLATKTWEQV 168
Query: 145 GTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNG-----NDVHVCNVKYKRWALLSC 199
+ G P + +V L++FGG F ES NDV+ N+ W+ LS
Sbjct: 169 KSTG-GPSGRSGHRMVAWKRQLILFGG----FHESTRDYIYYNDVYAFNLDTFTWSKLSP 223
Query: 200 RGKKPSRIYGQAMAII-NGSLYVFGGTTGYIYSTDLHKLDLNT----------RE----W 244
G P+ G M++ G + V+GG + D+ K ++ RE W
Sbjct: 224 SGTGPTPRSGCQMSVTPQGGIVVYGGYSKQRVKKDVDKGTRHSDMFLLKPEDGREDKWVW 283
Query: 245 TQLKPNNLSCDLPEERYRHEIAHDGQRIYILG-----GGTSWTAYSLNKIHAYNLETNAW 299
T++ P+ + P + +A + Q ++ G S + N ++ Y+ N W
Sbjct: 284 TRMNPSGVK-PTPRSGFSVAMAPNHQTLFFGGVCDEEEEESLSGEFFNDLYFYDATRNRW 342
Query: 300 EE 301
E
Sbjct: 343 FE 344
Score = 53.1 bits (126), Expect = 5e-07
Identities = 41/133 (30%), Positives = 62/133 (46%), Gaps = 10/133 (7%)
Query: 127 LFRELWRYHFATGVWHQMGTDGYMPRELASMSLVL--HGNNLLVFGGT-GIPFGES--NG 181
L+ EL+ Y+ W ++ PR A ++V+ G L VFGG P GE +
Sbjct: 93 LYNELYVYNTRKDTWTKVDIPSPPPRRCAHQAVVVPQGGGQLWVFGGEFASPNGEQFYHY 152
Query: 182 NDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGG----TTGYIYSTDLHKL 237
D+ V ++ K W + G PS G M L +FGG T YIY D++
Sbjct: 153 KDLWVLHLATKTWEQVKSTG-GPSGRSGHRMVAWKRQLILFGGFHESTRDYIYYNDVYAF 211
Query: 238 DLNTREWTQLKPN 250
+L+T W++L P+
Sbjct: 212 NLDTFTWSKLSPS 224
Score = 52.0 bits (123), Expect = 1e-06
Identities = 45/182 (24%), Positives = 78/182 (42%), Gaps = 24/182 (13%)
Query: 214 IINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHE---IAHDGQ 270
I+ G Y F G ++Y+ +L+ + WT++ + P R H+ + G
Sbjct: 79 ILFGGEY-FNGQKTFLYN-ELYVYNTRKDTWTKVDIPSP----PPRRCAHQAVVVPQGGG 132
Query: 271 RIYILGGG----TSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKN 326
++++ GG Y + +L T WE++ + G P+ R H V K
Sbjct: 133 QLWVFGGEFASPNGEQFYHYKDLWVLHLATKTWEQV-----KSTGGPSGRSGHRMVAWKR 187
Query: 327 DVFICGGYNGE----VILGDIWKLNLQTFQWVKL--PATMPEPVYFHCAAVTPAGCMYIH 380
+ + GG++ + D++ NL TF W KL T P P +VTP G + ++
Sbjct: 188 QLILFGGFHESTRDYIYYNDVYAFNLDTFTWSKLSPSGTGPTPRSGCQMSVTPQGGIVVY 247
Query: 381 GG 382
GG
Sbjct: 248 GG 249
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 63.9 bits (154), Expect = 3e-10
Identities = 48/177 (27%), Positives = 72/177 (40%), Gaps = 17/177 (9%)
Query: 177 GESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHK 236
G S N + + + RW ++C + P +G A + G +Y+ GG Y + +
Sbjct: 301 GGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAY--LKGYVYIIGGFDSVDYFNSVKR 358
Query: 237 LDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLET 296
D + W Q+ P + R + G IY +GG + LN Y ET
Sbjct: 359 FDPVKKTWHQVAP------MHSRRCYVSVTVLGNFIYAMGGFDGYVR--LNTAERYEPET 410
Query: 297 NAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW 353
N W IA HE+ R S + V+ICGG+NG L N ++ QW
Sbjct: 411 NQWTLIAPM-HEQ------RSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQW 460
Score = 39.3 bits (90), Expect = 0.007
Identities = 28/126 (22%), Positives = 48/126 (38%), Gaps = 15/126 (11%)
Query: 211 AMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQ 270
++ ++ +Y GG GY+ + + T +WT + P + E+R
Sbjct: 380 SVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAP------MHEQRSDASATTLYG 433
Query: 271 RIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFI 330
++YI GG L YN E+N W IA + G + V+
Sbjct: 434 KVYICGGFNG--NECLFTAEVYNTESNQWTVIAPMRSRRSGI-------GVIAYGEHVYA 484
Query: 331 CGGYNG 336
GG++G
Sbjct: 485 VGGFDG 490
>gi|46410931 attractin-like 1 [Homo sapiens]
Length = 1379
Score = 60.8 bits (146), Expect = 2e-09
Identities = 80/340 (23%), Positives = 140/340 (41%), Gaps = 61/340 (17%)
Query: 78 IPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFA 137
+PN ++ P R+ H+ V ++V GGY +Y F+ + Y+
Sbjct: 293 LPN--VKPFSPSVGRASHKAVLHGKFMWVIGGYTFNYSS-----------FQMVLNYNLE 339
Query: 138 TGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGND-VHVCNVKYKRWAL 196
+ +W+ +GT P + SL L+ N+ ++GG I + N D + V N+ + W+
Sbjct: 340 SSIWN-VGTPSRGPLQRYGHSLALYQENIFMYGGR-IETNDGNVTDELWVFNIHSQSWST 397
Query: 197 LSCRGKKPSRI-YGQAMAIINGS-------------LYVFGGTTGYIYSTDLHKLDLNTR 242
K P+ + +GQ A+ S + +FG + Y Y++ + + +++
Sbjct: 398 -----KTPTVLGHGQQYAVEGHSAHIMELDSRDVVMIIIFGYSAIYGYTSSIQEYHISSN 452
Query: 243 EWTQLKPNNLSCDLPEERYRHEIAHD--GQRIYILGG--GTSWTAYSL-NKIHAYNLETN 297
W L P + + Y H +D + IY+ GG Y L + ++ Y + T
Sbjct: 453 TW--LVPETKGA-IVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTK 509
Query: 298 AWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGG--------YNG-EVILGDIWKLNL 348
W + ++ GF AR HS V I + I GG NG + D ++
Sbjct: 510 TWTIL-----KESGF--ARYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDI 562
Query: 349 QTFQWVKLPA--TMPEPVYFHCAAVTPAGCMYIHGGVVNI 386
+W LP + F +AV G MYI GG ++
Sbjct: 563 ACDEWKILPKPNLHRDVNRFGHSAVVINGSMYIFGGFSSV 602
Score = 58.9 bits (141), Expect = 9e-09
Identities = 66/272 (24%), Positives = 109/272 (40%), Gaps = 29/272 (10%)
Query: 87 RPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWH--QM 144
R P R GH N++++GG D + + + + + W T + H Q
Sbjct: 350 RGPLQRYGHSLALYQENIFMYGGRIETNDGNVTDELWVFNIHSQSWSTKTPTVLGHGQQY 409
Query: 145 GTDGYMPR--ELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGK 202
+G+ EL S +V+ +++FG + I S+ + H+ + W + +G
Sbjct: 410 AVEGHSAHIMELDSRDVVM----IIIFGYSAIYGYTSSIQEYHISS---NTWLVPETKGA 462
Query: 203 KPSRIYGQAMAI--INGSLYVFGGTTG-----YIYSTDLHKLDLNTREWTQLKPNNLSCD 255
YG I S+YV GG Y DL+K ++NT+ WT LK + +
Sbjct: 463 IVQGGYGHTSVYDEITKSIYVHGGYKALPGNKYGLVDDLYKYEVNTKTWTILKESGFA-- 520
Query: 256 LPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAW----EEIATKPHEKIG 311
RY H + I GG T N ++ + A+ +E P +
Sbjct: 521 ----RYLHSAVLINGAMLIFGGNTHNDTSLSNGAKCFSADFLAYDIACDEWKILPKPNLH 576
Query: 312 FPAARRCHSCVQIKNDVFICGGYNGEVILGDI 343
R HS V I ++I GG++ V+L DI
Sbjct: 577 RDVNRFGHSAVVINGSMYIFGGFS-SVLLNDI 607
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 60.1 bits (144), Expect = 4e-09
Identities = 56/227 (24%), Positives = 92/227 (40%), Gaps = 43/227 (18%)
Query: 108 GGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGT-DGYMPRELASMSLVLHGNNL 166
GG+N Y E P TG W + + E A +L N++
Sbjct: 325 GGFNLPYTECYDP----------------VTGEWKSLAKLPEFTKSEYAVCAL---RNDI 365
Query: 167 LVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTT 226
LV GG N DV + N + W ++ K R MA++ G +YV GG
Sbjct: 366 LVSGG------RINSRDVWIYNSQLNIWIRVASLNKGRWR---HKMAVLLGKVYVVGGYD 416
Query: 227 GYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSL 286
G + + D + WT++ P L E + +++++GGG S
Sbjct: 417 GQNRLSSVECYDSFSNRWTEVAP------LKEAVSSPAVTSCVGKLFVIGGGPDDNTCS- 469
Query: 287 NKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGG 333
+K+ +Y+ ETN+W + P A+RC + V + N +++ GG
Sbjct: 470 DKVQSYDPETNSW-------LLRAAIPIAKRCITAVSLNNLIYVAGG 509
Score = 35.0 bits (79), Expect = 0.14
Identities = 29/126 (23%), Positives = 56/126 (44%), Gaps = 12/126 (9%)
Query: 257 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAAR 316
P R R + + I ++GG ++L Y+ T W+ +A P +
Sbjct: 301 PRTRPRRSTGYS-EVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPE------FTK 353
Query: 317 RCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGC 376
++ ++ND+ + G G + D+W N Q W+++ A++ + + H AV G
Sbjct: 354 SEYAVCALRNDILVSG---GRINSRDVWIYNSQLNIWIRV-ASLNKGRWRHKMAVL-LGK 408
Query: 377 MYIHGG 382
+Y+ GG
Sbjct: 409 VYVVGG 414
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 55.5 bits (132), Expect = 1e-07
Identities = 43/160 (26%), Positives = 73/160 (45%), Gaps = 18/160 (11%)
Query: 229 IYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTA---YS 285
+ S +L D EW L P D P RY+H IA G +Y++GG +++ +
Sbjct: 354 VVSKELRMYDEKAHEWKSLAP----MDAP--RYQHGIAVIGNFLYVVGGQSNYDTKGKTA 407
Query: 286 LNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWK 345
++ + ++ N W ++A+ ++ F + +K ++ GG N L +
Sbjct: 408 VDTVFRFDPRYNKWMQVASLNEKRTFFHLS-------ALKGYLYAVGGRNAAGELPTVEC 460
Query: 346 LNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVN 385
N +T +W + A M EP Y H V G MYI GG+ +
Sbjct: 461 YNPRTNEWTYV-AKMSEPHYGHAGTVY-GGVMYISGGITH 498
Score = 42.0 bits (97), Expect = 0.001
Identities = 44/182 (24%), Positives = 74/182 (40%), Gaps = 29/182 (15%)
Query: 184 VHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTRE 243
V N + W ++ K YG A + G +Y+ GG T + +L D +T +
Sbjct: 458 VECYNPRTNEWTYVA---KMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDK 514
Query: 244 WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGG----GTSWTAYSLNKIHAYNLETNAW 299
W Q P + R H + G+R+Y++GG GTS + Y+ + W
Sbjct: 515 WIQKAP------MTTVRGLHCMCTVGERLYVIGGNHFRGTS-DYDDVLSCEYYSPILDQW 567
Query: 300 EEIATKPHEKIGFPAARRCHSCVQI---KNDVFICGGY--NGEVILGDIWKLNLQTFQWV 354
IA A R S V + +N +++ GGY N ++ + K + +W
Sbjct: 568 TPIA----------AMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWH 617
Query: 355 KL 356
K+
Sbjct: 618 KV 619
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/181 (23%), Positives = 69/181 (38%), Gaps = 24/181 (13%)
Query: 208 YGQAMAIINGSLYVFGG-----TTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYR 262
Y +A+I LYV GG T G + + D +W Q+ L E+R
Sbjct: 380 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQV------ASLNEKRTF 433
Query: 263 HEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCV 322
++ +Y +GG + A L + YN TN W +A G H+
Sbjct: 434 FHLSALKGYLYAVGGRNA--AGELPTVECYNPRTNEWTYVAKMSEPHYG-------HAGT 484
Query: 323 QIKNDVFICGGYNGEVILGDIWKLNLQTFQWV-KLPATMPEPVYFHCAAVTPAGCMYIHG 381
++I GG + ++ + T +W+ K P T ++ C T +Y+ G
Sbjct: 485 VYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMC---TVGERLYVIG 541
Query: 382 G 382
G
Sbjct: 542 G 542
>gi|62955044 F-box protein 42 [Homo sapiens]
Length = 717
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/186 (27%), Positives = 82/186 (44%), Gaps = 23/186 (12%)
Query: 101 NTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLV 160
N ++YVFGG + F +LWR + W + G P A +LV
Sbjct: 130 NQSMYVFGGCTQSSCNAA---------FNDLWRLDLNSKEWIRPLASGSYPSPKAGATLV 180
Query: 161 LHGNNLLVFGGTGIPF------GESNGNDVHVCNVKYKRW-ALLSCRGKKPSRIYGQAMA 213
++ + L++FGG P E +++H + W +++ G P + G +
Sbjct: 181 VYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPP--MAGHSSC 238
Query: 214 IINGSLYVFGGTTG-YIYSTDLHKLDLNTREWTQLKPNNLSCDLPEER-YRHEIAHDGQR 271
+I+ + VFGG+ G S D+ LDL +W KP N+S P R + +I D
Sbjct: 239 VIDDKMIVFGGSLGSRQMSNDVWVLDL--EQWAWSKP-NISGPSPHPRGGQSQIVIDDAT 295
Query: 272 IYILGG 277
I ILGG
Sbjct: 296 ILILGG 301
Score = 53.1 bits (126), Expect = 5e-07
Identities = 46/159 (28%), Positives = 70/159 (44%), Gaps = 19/159 (11%)
Query: 216 NGSLYVFGGTTGYIYST---DLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRI 272
N S+YVFGG T + DL +LDLN++EW ++P S P + + +
Sbjct: 130 NQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEW--IRPL-ASGSYPSPKAGATLVVYKDLL 186
Query: 273 YILGGGTSWTAYSLNK-------IHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIK 325
+ GG T + Y L++ IH Y+ N W I T P HS I
Sbjct: 187 VLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHG-----PPPMAGHSSCVID 241
Query: 326 NDVFICGGYNGE-VILGDIWKLNLQTFQWVKLPATMPEP 363
+ + + GG G + D+W L+L+ + W K + P P
Sbjct: 242 DKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSP 280
Score = 37.7 bits (86), Expect = 0.021
Identities = 46/200 (23%), Positives = 77/200 (38%), Gaps = 13/200 (6%)
Query: 89 PPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDG 148
P ++G V L +FGG+ S P ++ F E+ Y + W+ + T
Sbjct: 171 PSPKAGATLVVYKDLLVLFGGWTRP---SPYPLHQPERFFDEIHTYSPSKNWWNCIVTT- 226
Query: 149 YMPRELASMSLVLHGNNLLVFGGTGIPFGESN-GNDVHVCNVKYKRWALLSCRGKKPSRI 207
+ P +A S + + ++VFGG+ G NDV V +++ W+ + G P
Sbjct: 227 HGPPPMAGHSSCVIDDKMIVFGGS---LGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPR 283
Query: 208 YGQAMAIINGSLYVF----GGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRH 263
GQ+ +I+ + + GG L + W LK N P E + H
Sbjct: 284 GGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAP-ELWCH 342
Query: 264 EIAHDGQRIYILGGGTSWTA 283
GQ + + S A
Sbjct: 343 PACRVGQCVVVFSQAPSGRA 362
Score = 31.2 bits (69), Expect = 2.0
Identities = 27/97 (27%), Positives = 37/97 (38%), Gaps = 13/97 (13%)
Query: 80 NRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATG 139
N + H PPP CV D+ + VFGG S N+ + L E W
Sbjct: 221 NCIVTTHGPPPMAGHSSCVIDD-KMIVFGGSLGSRQMS----NDVWVLDLEQW------- 268
Query: 140 VWHQMGTDGYMPRELASMS-LVLHGNNLLVFGGTGIP 175
W + G P S +V+ +L+ GG G P
Sbjct: 269 AWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGP 305
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 52.8 bits (125), Expect = 6e-07
Identities = 66/290 (22%), Positives = 101/290 (34%), Gaps = 66/290 (22%)
Query: 143 QMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGND----VHVCNVKYKRWALLS 198
+M D + + ++ M G G I G N + V N W+ L+
Sbjct: 340 EMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLA 399
Query: 199 CRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDL---HKLDLNTREW---TQLKPNNL 252
+R MA++ G LYV GG+ G +S DL D N +W +L+ N
Sbjct: 400 PMRTPRARFQ---MAVLMGQLYVVGGSNG--HSDDLSCGEMYDSNIDDWIPVPELRTNRC 454
Query: 253 --------------------------SCD--------------LPEERYRHEIAHDGQRI 272
+CD L R++ + G +
Sbjct: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514
Query: 273 YILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICG 332
YI+GG SW LN + YN E N W IA ARR + +F+CG
Sbjct: 515 YIIGGAESWNC--LNTVERYNPENNTWTLIAP-------MNVARRGAGVAVLNGKLFVCG 565
Query: 333 GYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGG 382
G++G + + + +W K+ M P + T +Y GG
Sbjct: 566 GFDGSHAISCVEMYDPTRNEW-KMMGNMTSP-RSNAGIATVGNTIYAVGG 613
Score = 51.2 bits (121), Expect = 2e-06
Identities = 44/183 (24%), Positives = 69/183 (37%), Gaps = 54/183 (29%)
Query: 215 INGSLYVFGGTTGY----IYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQ 270
+NG LY+ GG+ Y + + D+ D T+ WT P N+ R++ + G
Sbjct: 461 LNGKLYIVGGSDPYGQKGLKNCDV--FDPVTKLWTSCAPLNI------RRHQSAVCELGG 512
Query: 271 RIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAA--------------R 316
+YI+GG SW LN + YN E N W IA + G A
Sbjct: 513 YLYIIGGAESWNC--LNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGS 570
Query: 317 RCHSCVQ--------------------------IKNDVFICGGYNGEVILGDIWKLNLQT 350
SCV+ + N ++ GG++G L + NL++
Sbjct: 571 HAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLES 630
Query: 351 FQW 353
+W
Sbjct: 631 NEW 633
Score = 49.7 bits (117), Expect = 5e-06
Identities = 58/235 (24%), Positives = 90/235 (38%), Gaps = 52/235 (22%)
Query: 88 PPPARSGHRCVAD----NTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQ 143
P P +RC A N LY+ GG +P Y + G + + + +LW
Sbjct: 445 PVPELRTNRCNAGVCALNGKLYIVGGSDP-YGQKGLKNCDVFDPVTKLWT---------- 493
Query: 144 MGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNG----NDVHVCNVKYKRWALLSC 199
A +++ H + + GG G + N V N + W L++
Sbjct: 494 ---------SCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIA- 543
Query: 200 RGKKPSRIY--GQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLP 257
P + G +A++NG L+V GG G + + D EW + ++
Sbjct: 544 ----PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMG------NMT 593
Query: 258 EERYRHEIAHDGQRIYILGG--GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKI 310
R IA G IY +GG G + LN + YNLE+N W P+ KI
Sbjct: 594 SPRSNAGIATVGNTIYAVGGFDGNEF----LNTVEVYNLESNEW-----SPYTKI 639
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 52.4 bits (124), Expect = 8e-07
Identities = 55/249 (22%), Positives = 101/249 (40%), Gaps = 39/249 (15%)
Query: 98 VADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASM 157
V+ + +YV GGY+ + DY + GVW+ + + R LA
Sbjct: 325 VSLHDRIYVIGGYD-GRSRLSSVECLDYTADED--------GVWYSVAPMN-VRRGLAGA 374
Query: 158 SLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIING 217
+ + G+ + V GG G + + +W++L G + G + + +G
Sbjct: 375 TTL--GDMIYVSGGFD---GSRRHTSMERYDPNIDQWSML---GDMQTAREGAGLVVASG 426
Query: 218 SLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGG 277
+Y GG G + K D +T WT + P + +R +A IY++GG
Sbjct: 427 VIYCLGGYDGLNILNSVEKYDPHTGHWTNVTP------MATKRSGAGVALLNDHIYVVGG 480
Query: 278 --GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCH-SCVQIKNDVFICGGY 334
GT+ L+ + AYN+ T++W + + RC+ ++ ++ GY
Sbjct: 481 FDGTA----HLSSVEAYNIRTDSWTTVTSM--------TTPRCYVGATVLRGRLYAIAGY 528
Query: 335 NGEVILGDI 343
+G +L I
Sbjct: 529 DGNSLLSSI 537
Score = 43.9 bits (102), Expect = 3e-04
Identities = 34/136 (25%), Positives = 55/136 (40%), Gaps = 17/136 (12%)
Query: 219 LYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGG 278
+YV GG G T + + D N +W+ L D+ R + IY LGG
Sbjct: 381 IYVSGGFDGSRRHTSMERYDPNIDQWSMLG------DMQTAREGAGLVVASGVIYCLGGY 434
Query: 279 TSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKND-VFICGGYNGE 337
LN + Y+ T W + A +R + V + ND +++ GG++G
Sbjct: 435 DGLNI--LNSVEKYDPHTGHWTNVTPM--------ATKRSGAGVALLNDHIYVVGGFDGT 484
Query: 338 VILGDIWKLNLQTFQW 353
L + N++T W
Sbjct: 485 AHLSSVEAYNIRTDSW 500
Score = 35.0 bits (79), Expect = 0.14
Identities = 44/194 (22%), Positives = 71/194 (36%), Gaps = 23/194 (11%)
Query: 166 LLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGT 225
LLV GG G +S + V + K + W+ L +K + A ++ +YV GG
Sbjct: 283 LLVVGGFGSQ--QSPIDVVEKYDPKTQEWSFLPSITRKRRYV---ASVSLHDRIYVIGGY 337
Query: 226 TGYIYSTDLHKLDLNTRE---WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWT 282
G + + LD E W + P N+ L G IY+ GG
Sbjct: 338 DGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTL------GDMIYVSGGFDGSR 391
Query: 283 AYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGD 342
++ + Y+ + W + AR V ++ GGY+G IL
Sbjct: 392 RHT--SMERYDPNIDQWSMLGD-------MQTAREGAGLVVASGVIYCLGGYDGLNILNS 442
Query: 343 IWKLNLQTFQWVKL 356
+ K + T W +
Sbjct: 443 VEKYDPHTGHWTNV 456
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 52.4 bits (124), Expect = 8e-07
Identities = 41/160 (25%), Positives = 72/160 (45%), Gaps = 18/160 (11%)
Query: 229 IYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTA---YS 285
+ S +L D +EW L P D P RY+H IA G +Y++GG +++ +
Sbjct: 312 VVSKELRMYDERAQEWRSLAP----MDAP--RYQHGIAVIGNFLYVVGGQSNYDTKGKTA 365
Query: 286 LNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWK 345
++ + ++ N W ++A+ ++ F + +K ++ GG + L +
Sbjct: 366 VDTVFRFDPRYNKWMQVASLNEKRTFFHLS-------ALKGHLYAVGGRSAAGELATVEC 418
Query: 346 LNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVN 385
N + +W A M EP Y H V G MYI GG+ +
Sbjct: 419 YNPRMNEW-SYVAKMSEPHYGHAGTVY-GGLMYISGGITH 456
Score = 42.7 bits (99), Expect = 7e-04
Identities = 43/182 (23%), Positives = 75/182 (41%), Gaps = 29/182 (15%)
Query: 184 VHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTRE 243
V N + W+ ++ K YG A + G +Y+ GG T + +L D +T +
Sbjct: 416 VECYNPRMNEWSYVA---KMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDK 472
Query: 244 WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGG----GTSWTAYSLNKIHAYNLETNAW 299
W Q P + R H + G ++Y++GG GTS + Y+ + W
Sbjct: 473 WMQKAP------MTTVRGLHCMCTVGDKLYVIGGNHFRGTS-DYDDVLSCEYYSPTLDQW 525
Query: 300 EEIATKPHEKIGFPAARRCHSCVQI---KNDVFICGGY--NGEVILGDIWKLNLQTFQWV 354
IA A R S V + +N +++ GGY N ++ + K + + +W
Sbjct: 526 TPIA----------AMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
Query: 355 KL 356
K+
Sbjct: 576 KV 577
Score = 40.0 bits (92), Expect = 0.004
Identities = 41/181 (22%), Positives = 69/181 (38%), Gaps = 24/181 (13%)
Query: 208 YGQAMAIINGSLYVFGG-----TTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYR 262
Y +A+I LYV GG T G + + D +W Q+ L E+R
Sbjct: 338 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQV------ASLNEKRTF 391
Query: 263 HEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCV 322
++ +Y +GG ++ A L + YN N W +A G H+
Sbjct: 392 FHLSALKGHLYAVGGRSA--AGELATVECYNPRMNEWSYVAKMSEPHYG-------HAGT 442
Query: 323 QIKNDVFICGGYNGEVILGDIWKLNLQTFQWV-KLPATMPEPVYFHCAAVTPAGCMYIHG 381
++I GG + ++ + T +W+ K P T ++ C T +Y+ G
Sbjct: 443 VYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMC---TVGDKLYVIG 499
Query: 382 G 382
G
Sbjct: 500 G 500
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/222 (22%), Positives = 92/222 (41%), Gaps = 24/222 (10%)
Query: 134 YHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR 193
Y+ + G W ++ D +PR V+ G V G P G ++ + + N +
Sbjct: 345 YNPSDGTWLRLA-DLQVPRS-GLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ 402
Query: 194 WALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS 253
W+ + +RI + +I+G +Y GG+ G I+ + + + EW + P
Sbjct: 403 WSPCAPMSVPRNRI---GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAP---- 455
Query: 254 CDLPEERYRHEIAHDGQRIYILGG--GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIG 311
+ R +A + +Y +GG GT+ LN Y E N W I + G
Sbjct: 456 --MLTRRIGVGVAVLNRLLYAVGGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSG 509
Query: 312 FPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW 353
CV + N ++ GGY+G+ L + + +++T W
Sbjct: 510 ------AGVCV-LHNCIYAAGGYDGQDQLNSVERYDVETETW 544
Score = 29.3 bits (64), Expect = 7.5
Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 160 VLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSL 219
VLH N + GG G+ N V +V+ + W ++ + S + + + G +
Sbjct: 514 VLH-NCIYAAGGYD---GQDQLNSVERYDVETETWTFVAPMKHRRSAL---GITVHQGRI 566
Query: 220 YVFGGTTGYIYSTDLHKLDLNTREWTQL 247
YV GG G+ + + D +T W+++
Sbjct: 567 YVLGGYDGHTFLDSVECYDPDTDTWSEV 594
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 50.8 bits (120), Expect = 2e-06
Identities = 51/222 (22%), Positives = 92/222 (41%), Gaps = 24/222 (10%)
Query: 134 YHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR 193
Y+ + G W ++ D +PR V+ G V G P G ++ + + N +
Sbjct: 345 YNPSDGTWLRLA-DLQVPRS-GLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ 402
Query: 194 WALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS 253
W+ + +RI + +I+G +Y GG+ G I+ + + + EW + P
Sbjct: 403 WSPCAPMSVPRNRI---GVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAP---- 455
Query: 254 CDLPEERYRHEIAHDGQRIYILGG--GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIG 311
+ R +A + +Y +GG GT+ LN Y E N W I + G
Sbjct: 456 --MLTRRIGVGVAVLNRLLYAVGGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSG 509
Query: 312 FPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW 353
CV + N ++ GGY+G+ L + + +++T W
Sbjct: 510 ------AGVCV-LHNCIYAAGGYDGQDQLNSVERYDVETETW 544
Score = 29.3 bits (64), Expect = 7.5
Identities = 21/88 (23%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 160 VLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSL 219
VLH N + GG G+ N V +V+ + W ++ + S + + + G +
Sbjct: 514 VLH-NCIYAAGGYD---GQDQLNSVERYDVETETWTFVAPMKHRRSAL---GITVHQGRI 566
Query: 220 YVFGGTTGYIYSTDLHKLDLNTREWTQL 247
YV GG G+ + + D +T W+++
Sbjct: 567 YVLGGYDGHTFLDSVECYDPDTDTWSEV 594
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 50.1 bits (118), Expect = 4e-06
Identities = 60/252 (23%), Positives = 94/252 (37%), Gaps = 35/252 (13%)
Query: 150 MPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKKPSRI-- 207
+P S G + + GG G G S DV V + ++ W+ + P +
Sbjct: 326 IPSPRKEFSACAIGCKVYITGGRGSENGVSK--DVWVYDTLHEEWSKAA-----PMLVAR 378
Query: 208 YGQAMAIINGSLYVFGGTTGY---------IYSTDLHKLDLNTREWTQLKPNNLSCDLPE 258
+G A + LYV GG T + + D +WT + P L E
Sbjct: 379 FGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAP------LRE 432
Query: 259 ERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRC 318
+ +++ GG TS + L K+ Y+ N W AT P R
Sbjct: 433 GVSNAAVVSAKLKLFAFGG-TSVSHDKLPKVQCYDQCENRWTVPATCPQPW-------RY 484
Query: 319 HSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMY 378
+ + N +FI GG + E +K N +T+QW K+ + + C AV +Y
Sbjct: 485 TAAAVLGNQIFIMGG-DTEFSACSAYKFNSETYQWTKVGDVTAKRM--SCHAVASGNKLY 541
Query: 379 IHGGVVNIHENK 390
+ GG I K
Sbjct: 542 VVGGYFGIQRCK 553
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 49.3 bits (116), Expect = 7e-06
Identities = 54/250 (21%), Positives = 102/250 (40%), Gaps = 34/250 (13%)
Query: 134 YHFATGVWHQMGT-DGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYK 192
YH + W + + GY E A+ +L N++ V GG N +DV + +
Sbjct: 102 YHPESQRWTPLPSLPGYTRSEFAACAL---RNDVYVSGG------HINSHDVWMFSSHLH 152
Query: 193 RWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL 252
W ++ K R MA++ G L+ GG G + + D + W P
Sbjct: 153 TWIKVASLHKGRWR---HKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAP--- 206
Query: 253 SCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGF 312
LPE +A +++++GG + +K+ ++ + + W + P
Sbjct: 207 ---LPEAVSSAAVASCAGKLFVIGGARQ-GGVNTDKVQCFDPKEDRWSLRSPAPF----- 257
Query: 313 PAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVT 372
++RC V +++ +++ GG ++ I+ + T W + A +P PV C
Sbjct: 258 --SQRCLEAVSLEDTIYVMGG-----LMSKIFTYDPGTDVWGE-AAVLPSPVE-SCGVTV 308
Query: 373 PAGCMYIHGG 382
G ++I GG
Sbjct: 309 CDGKVHILGG 318
Score = 29.3 bits (64), Expect = 7.5
Identities = 18/64 (28%), Positives = 28/64 (43%), Gaps = 1/64 (1%)
Query: 352 QWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWE 411
+W LP+ +P AA +Y+ GG +N H+ S W+ V SL + W
Sbjct: 108 RWTPLPS-LPGYTRSEFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVASLHKGRWR 166
Query: 412 KLLA 415
+A
Sbjct: 167 HKMA 170
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 49.3 bits (116), Expect = 7e-06
Identities = 62/245 (25%), Positives = 98/245 (40%), Gaps = 36/245 (14%)
Query: 130 ELWRYHF-ATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGT-GIPFGESNGNDVHVC 187
E++RYH W ++ T + REL ++ + N+L V GG I N V
Sbjct: 354 EIYRYHDRGNQFWEKLCTAEF--RELYALGSI--HNDLYVIGGQMKIKNQYLITNCVDKY 409
Query: 188 NVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYI---------YSTDLHKLD 238
+V+ W +S P ++ A+ +N LYV GG T + S L + D
Sbjct: 410 SVERDNWKRVS---PLPLQLACHAVVTVNNKLYVIGGWTPQMDLPDEEPDRLSNKLLQYD 466
Query: 239 LNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGG------GTSWTAYSLNKIHAY 292
+ +W+ P S +YR A IY+LGG L+ + Y
Sbjct: 467 PSQDQWSVRAPMKYS------KYRFSTAVVNSEIYVLGGIGCVGQDKGQVRKCLDVVEIY 520
Query: 293 NLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNG----EVILGDIWKLNL 348
N + + W E P + V K +++CGG++G EVI +I +L+
Sbjct: 521 NPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGK--LYVCGGFHGADRHEVISKEILELDP 578
Query: 349 QTFQW 353
QW
Sbjct: 579 WENQW 583
Score = 36.2 bits (82), Expect = 0.061
Identities = 46/179 (25%), Positives = 65/179 (36%), Gaps = 31/179 (17%)
Query: 95 HRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPREL 154
H V N LYV GG+ P D PD E L +L +Y + W Y
Sbjct: 429 HAVVTVNNKLYVIGGWTPQMDL---PDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYR- 484
Query: 155 ASMSLVLHGNNLLVFGGTGIPFGESNG------NDVHVCNVKYKRW--------ALLSCR 200
S + + + V GG G G+ G + V + N W LLS R
Sbjct: 485 --FSTAVVNSEIYVLGGIGC-VGQDKGQVRKCLDVVEIYNPDGDFWREGPPMPSPLLSLR 541
Query: 201 GKKPSRIYGQAMAIINGSLYVFGGTTG----YIYSTDLHKLDLNTREWTQLKPNNLSCD 255
+ ++G LYV GG G + S ++ +LD +W + N L D
Sbjct: 542 TNSTN------AGAVDGKLYVCGGFHGADRHEVISKEILELDPWENQWNVVAINVLMHD 594
Score = 29.6 bits (65), Expect = 5.7
Identities = 25/106 (23%), Positives = 48/106 (45%), Gaps = 8/106 (7%)
Query: 282 TAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGY----NGE 337
+A L++ N+E + + + EK+ R ++ I ND+++ GG N
Sbjct: 341 SASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEFRELYALGSIHNDLYVIGGQMKIKNQY 400
Query: 338 VILGDIWKLNLQTFQWVKLPATMPEPVYFHC-AAVTPAGCMYIHGG 382
+I + K +++ W ++ P P+ C A VT +Y+ GG
Sbjct: 401 LITNCVDKYSVERDNWKRV---SPLPLQLACHAVVTVNNKLYVIGG 443
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 48.9 bits (115), Expect = 9e-06
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 211 AMAIINGSLYVFGGT---TGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAH 267
A G +Y GG+ +Y + + D T W KP+ L+ +R H +
Sbjct: 376 AACAAEGKIYTSGGSEVGNSALYLFECY--DTRTESW-HTKPSMLT-----QRCSHGMVE 427
Query: 268 DGQRIYILGG--GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIK 325
IY+ GG G + + LN Y+ T W E+ AR+ H V +K
Sbjct: 428 ANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIE-------ARKNHGLVFVK 480
Query: 326 NDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMP-EPVYFHCAAV 371
+ +F GG NG L ++ +++ +W K+ + MP + V CAAV
Sbjct: 481 DKIFAVGGQNGLGGLDNVEYYDIKLNEW-KMVSPMPWKGVTVKCAAV 526
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 48.9 bits (115), Expect = 9e-06
Identities = 45/167 (26%), Positives = 72/167 (43%), Gaps = 22/167 (13%)
Query: 211 AMAIINGSLYVFGGT---TGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAH 267
A G +Y GG+ +Y + + D T W KP+ L+ +R H +
Sbjct: 354 AACAAEGKIYTSGGSEVGNSALYLFECY--DTRTESW-HTKPSMLT-----QRCSHGMVE 405
Query: 268 DGQRIYILGG--GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIK 325
IY+ GG G + + LN Y+ T W E+ AR+ H V +K
Sbjct: 406 ANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIE-------ARKNHGLVFVK 458
Query: 326 NDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMP-EPVYFHCAAV 371
+ +F GG NG L ++ +++ +W K+ + MP + V CAAV
Sbjct: 459 DKIFAVGGQNGLGGLDNVEYYDIKLNEW-KMVSPMPWKGVTVKCAAV 504
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 48.5 bits (114), Expect = 1e-05
Identities = 64/291 (21%), Positives = 112/291 (38%), Gaps = 59/291 (20%)
Query: 104 LYVFGGYNPDYDESGGPDNEDYPLFRELW---------RYHFATGVWHQM-----GTDG- 148
LY GG + + G E Y L LW R F V G DG
Sbjct: 461 LYAVGGMD---NNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGL 517
Query: 149 --------YMPRE-----LASMSLVLHGNNLLVFGGTGIPFGESNG----NDVHVCNVKY 191
Y P+ L MS HG + V G G +G N V + +
Sbjct: 518 KTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQS 577
Query: 192 KRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNN 251
++W ++ S + +A +NG LY GG G + + D +T +W N
Sbjct: 578 QQWTFVASMSIARSTV---GVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKW------N 628
Query: 252 LSCDLPEERYRHEIAHDGQRIYILGG----GTSWTAYSLNKIHAYNLETNAWEEIA--TK 305
+ + + R +A +Y +GG ++ + L+ + Y+ +T+ W +A +
Sbjct: 629 MCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSM 688
Query: 306 PHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKL 356
P + +G C+ + + ++ GGY+G+ L + + QT +W ++
Sbjct: 689 PRDAVGV--------CL-LGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQM 730
Score = 43.9 bits (102), Expect = 3e-04
Identities = 31/137 (22%), Positives = 56/137 (40%), Gaps = 15/137 (10%)
Query: 217 GSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILG 276
G+LY GG +T + K DL T W Q N R + +A +++++G
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMN------GRRLQFGVAVIDDKLFVIG 512
Query: 277 GGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNG 336
G +LN + YN +T W + + G ++ ++ GG++G
Sbjct: 513 GRDG--LKTLNTVECYNPKTKTWTVLPPMSTHRHGL-------GVTVLEGPIYAVGGHDG 563
Query: 337 EVILGDIWKLNLQTFQW 353
L + + + Q+ QW
Sbjct: 564 WSYLNTVERWDPQSQQW 580
Score = 32.7 bits (73), Expect = 0.68
Identities = 26/102 (25%), Positives = 44/102 (43%), Gaps = 14/102 (13%)
Query: 209 GQAMAIINGSLYVFGGTTGYIYS------TDLHKLDLNTREWTQLKPNNLSCDLPEERYR 262
G +A +G LY GG + + + D T WT + P ++ D
Sbjct: 639 GVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVG---- 694
Query: 263 HEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIAT 304
+ G R+Y +GG T LN + +Y+ +TN W ++A+
Sbjct: 695 --VCLLGDRLYAVGGYDGQTY--LNTMESYDPQTNEWTQMAS 732
Score = 31.6 bits (70), Expect = 1.5
Identities = 13/41 (31%), Positives = 19/41 (46%)
Query: 212 MAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL 252
+ ++ LY GG G Y + D T EWTQ+ N+
Sbjct: 695 VCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNI 735
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 48.1 bits (113), Expect = 2e-05
Identities = 36/132 (27%), Positives = 56/132 (42%), Gaps = 13/132 (9%)
Query: 204 PSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRH 263
P+ + A AI+ G LYV GG G T + L + KP + R H
Sbjct: 276 PAPCFAHAAAILEGQLYVSGGCGG----TGQYLASLMHYDPKLEKPGTFLSPMGVPRAGH 331
Query: 264 EIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQ 323
+A G R+Y+ GG L AY L T++W +A P +G +A
Sbjct: 332 VMAALGGRLYVAGG--LGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAASA-------V 382
Query: 324 IKNDVFICGGYN 335
++ ++ + GGY+
Sbjct: 383 LQGELLVLGGYS 394
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/147 (28%), Positives = 61/147 (41%), Gaps = 18/147 (12%)
Query: 239 LNTREWTQLKPNNLSCDLPEE-RYRHEIAH-DGQRIYILGGGTSWTAYSLNKIHAYNL-E 295
+ T EW QL LP R+RH A G +Y+ GG ++ H+ L
Sbjct: 165 VRTVEWGQLPA------LPAPGRFRHGAASLAGSELYVCGGQDFYS-------HSNTLAS 211
Query: 296 TNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVK 355
T WE E AR S V + ++ GG + +V L + N + W
Sbjct: 212 TLRWEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRP 271
Query: 356 LPATMPEPVYFHCAAVTPAGCMYIHGG 382
PA +P P + H AA+ G +Y+ GG
Sbjct: 272 APA-LPAPCFAHAAAIL-EGQLYVSGG 296
Score = 41.6 bits (96), Expect = 0.001
Identities = 60/255 (23%), Positives = 87/255 (34%), Gaps = 38/255 (14%)
Query: 60 IRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGG 119
+RW+P + + + P+ + ARS VA + LY GG + D
Sbjct: 213 LRWEPSQEDWEEMAPLSQ-------------ARSLFSLVALDGKLYALGGRHNDV----- 254
Query: 120 PDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGES 179
+ Y+ VW +P + + + L V GG G G+
Sbjct: 255 -------ALDSVETYNPELNVWRPAPA---LPAPCFAHAAAILEGQLYVSGGCG-GTGQY 303
Query: 180 NGNDVHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDL 239
+ +H K LS G + G MA + G LYV GG +L
Sbjct: 304 LASLMHYDPKLEKPGTFLSPMGVPRA---GHVMAALGGRLYVAGGLGETEDLLSFEAYEL 360
Query: 240 NTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAW 299
T WT L P LP A + +LGG + T + IHAY W
Sbjct: 361 RTDSWTHLAP------LPSPHVGAASAVLQGELLVLGGYSHRTYALSHLIHAYCPGLGRW 414
Query: 300 EEIATKPHEKIGFPA 314
+ T P + PA
Sbjct: 415 LCLGTLPRPRAEMPA 429
Score = 40.4 bits (93), Expect = 0.003
Identities = 32/136 (23%), Positives = 54/136 (39%), Gaps = 18/136 (13%)
Query: 204 PSRIYGQAMAIINGSLYVFGGTTGYIYSTDLH---KLDLNTREWTQLKPNNLSCDLPEER 260
P R A ++ LYV GG Y +S L + + + +W ++ P L + R
Sbjct: 179 PGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAP------LSQAR 232
Query: 261 YRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHS 320
+ ++Y LGG + A L+ + YN E N W PA H+
Sbjct: 233 SLFSLVALDGKLYALGGRHNDVA--LDSVETYNPELNVWRPAP-------ALPAPCFAHA 283
Query: 321 CVQIKNDVFICGGYNG 336
++ +++ GG G
Sbjct: 284 AAILEGQLYVSGGCGG 299
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/221 (21%), Positives = 83/221 (37%), Gaps = 24/221 (10%)
Query: 134 YHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR 193
Y F WHQ+ +P +V + GG G V + +
Sbjct: 238 YDFKEERWHQVAE---LPSRRCRAGMVYMAGLVFAVGGFN---GSLRVRTVDSYDPVKDQ 291
Query: 194 WALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS 253
W ++ + S + A++NG LY GG G + + ++ + EW + P N
Sbjct: 292 WTSVANMRDRRSTL---GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMN-- 346
Query: 254 CDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFP 313
R + G +Y +GG + L+ + YN TN W IA
Sbjct: 347 ----TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-------- 394
Query: 314 AARRCHSCVQIKND-VFICGGYNGEVILGDIWKLNLQTFQW 353
+ RR + V + N+ ++ GG++G ++ + + T W
Sbjct: 395 STRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 435
Score = 35.0 bits (79), Expect = 0.14
Identities = 25/121 (20%), Positives = 47/121 (38%), Gaps = 11/121 (9%)
Query: 184 VHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTRE 243
V N W ++ + +R G + ++N LY GG G + + D T
Sbjct: 378 VECYNATTNEWTYIA---EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 434
Query: 244 WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
W Q+ N+ R + +Y++GG + +L + YN T+ W ++
Sbjct: 435 WRQVADMNMC------RRNAGVCAVNGLLYVVGGDDG--SCNLASVEYYNPTTDKWTVVS 486
Query: 304 T 304
+
Sbjct: 487 S 487
Score = 29.6 bits (65), Expect = 5.7
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 13/113 (11%)
Query: 271 RIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHS-CVQIKNDVF 329
++ ++ GG + A + + Y+ + W ++A P +RRC + V + VF
Sbjct: 219 KLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELP--------SRRCRAGMVYMAGLVF 268
Query: 330 ICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGG 382
GG+NG + + + + QW + A M + AAV G +Y GG
Sbjct: 269 AVGGFNGSLRVRTVDSYDPVKDQWTSV-ANMRDRRSTLGAAVL-NGLLYAVGG 319
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/221 (21%), Positives = 83/221 (37%), Gaps = 24/221 (10%)
Query: 134 YHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR 193
Y F WHQ+ +P +V + GG G V + +
Sbjct: 330 YDFKEERWHQVAE---LPSRRCRAGMVYMAGLVFAVGGFN---GSLRVRTVDSYDPVKDQ 383
Query: 194 WALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS 253
W ++ + S + A++NG LY GG G + + ++ + EW + P N
Sbjct: 384 WTSVANMRDRRSTL---GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMN-- 438
Query: 254 CDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFP 313
R + G +Y +GG + L+ + YN TN W IA
Sbjct: 439 ----TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-------- 486
Query: 314 AARRCHSCVQIKND-VFICGGYNGEVILGDIWKLNLQTFQW 353
+ RR + V + N+ ++ GG++G ++ + + T W
Sbjct: 487 STRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 527
Score = 35.0 bits (79), Expect = 0.14
Identities = 25/121 (20%), Positives = 47/121 (38%), Gaps = 11/121 (9%)
Query: 184 VHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTRE 243
V N W ++ + +R G + ++N LY GG G + + D T
Sbjct: 470 VECYNATTNEWTYIA---EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 526
Query: 244 WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
W Q+ N+ R + +Y++GG + +L + YN T+ W ++
Sbjct: 527 WRQVADMNMC------RRNAGVCAVNGLLYVVGGDDG--SCNLASVEYYNPTTDKWTVVS 578
Query: 304 T 304
+
Sbjct: 579 S 579
Score = 29.6 bits (65), Expect = 5.7
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 13/113 (11%)
Query: 271 RIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHS-CVQIKNDVF 329
++ ++ GG + A + + Y+ + W ++A P +RRC + V + VF
Sbjct: 311 KLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELP--------SRRCRAGMVYMAGLVF 360
Query: 330 ICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGG 382
GG+NG + + + + QW + A M + AAV G +Y GG
Sbjct: 361 AVGGFNGSLRVRTVDSYDPVKDQWTSV-ANMRDRRSTLGAAVL-NGLLYAVGG 411
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 48.1 bits (113), Expect = 2e-05
Identities = 47/221 (21%), Positives = 83/221 (37%), Gaps = 24/221 (10%)
Query: 134 YHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKR 193
Y F WHQ+ +P +V + GG G V + +
Sbjct: 326 YDFKEERWHQVAE---LPSRRCRAGMVYMAGLVFAVGGFN---GSLRVRTVDSYDPVKDQ 379
Query: 194 WALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLS 253
W ++ + S + A++NG LY GG G + + ++ + EW + P N
Sbjct: 380 WTSVANMRDRRSTL---GAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMN-- 434
Query: 254 CDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFP 313
R + G +Y +GG + L+ + YN TN W IA
Sbjct: 435 ----TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM-------- 482
Query: 314 AARRCHSCVQIKND-VFICGGYNGEVILGDIWKLNLQTFQW 353
+ RR + V + N+ ++ GG++G ++ + + T W
Sbjct: 483 STRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAW 523
Score = 35.0 bits (79), Expect = 0.14
Identities = 25/121 (20%), Positives = 47/121 (38%), Gaps = 11/121 (9%)
Query: 184 VHVCNVKYKRWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTRE 243
V N W ++ + +R G + ++N LY GG G + + D T
Sbjct: 466 VECYNATTNEWTYIA---EMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNA 522
Query: 244 WTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIA 303
W Q+ N+ R + +Y++GG + +L + YN T+ W ++
Sbjct: 523 WRQVADMNMC------RRNAGVCAVNGLLYVVGGDDG--SCNLASVEYYNPTTDKWTVVS 574
Query: 304 T 304
+
Sbjct: 575 S 575
Score = 29.6 bits (65), Expect = 5.7
Identities = 28/113 (24%), Positives = 50/113 (44%), Gaps = 13/113 (11%)
Query: 271 RIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHS-CVQIKNDVF 329
++ ++ GG + A + + Y+ + W ++A P +RRC + V + VF
Sbjct: 307 KLMVVVGGQAPKA--IRSVECYDFKEERWHQVAELP--------SRRCRAGMVYMAGLVF 356
Query: 330 ICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGG 382
GG+NG + + + + QW + A M + AAV G +Y GG
Sbjct: 357 AVGGFNGSLRVRTVDSYDPVKDQWTSV-ANMRDRRSTLGAAVL-NGLLYAVGG 407
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 48.1 bits (113), Expect = 2e-05
Identities = 41/166 (24%), Positives = 70/166 (42%), Gaps = 17/166 (10%)
Query: 217 GSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILG 276
G+L+ GG +T + K DL T WT + ++ R + +A ++Y++G
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPV------ANMNGRRLQFGVAVLDDKLYVVG 474
Query: 277 GGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNG 336
G +LN + YN +T W + + G A ++ ++ GG++G
Sbjct: 475 GRDG--LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVA-------VLEGPMYAVGGHDG 525
Query: 337 EVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGG 382
L + + + Q QW ATM P AV +G +Y GG
Sbjct: 526 WSYLNTVERWDPQARQW-NFVATMSTPRSTVGVAVL-SGKLYAVGG 569
Score = 46.2 bits (108), Expect = 6e-05
Identities = 42/208 (20%), Positives = 85/208 (40%), Gaps = 24/208 (11%)
Query: 157 MSLVLHGNNLLVFGGTGIPFGESNG----NDVHVCNVKYKRWALLSCRGKKPSRIYGQAM 212
MS HG + V G G +G N V + + ++W ++ S + +
Sbjct: 501 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTV---GV 557
Query: 213 AIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNLSCDLPEERYRHEIAHDGQRI 272
A+++G LY GG G + D +T +WT L + + R + +
Sbjct: 558 AVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWT------LCAQMSKRRGGVGVTTWNGLL 611
Query: 273 YILGG----GTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDV 328
Y +GG ++ T+ + + Y+ +T+ W +A+ +R + + +
Sbjct: 612 YAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS-------MSISRDAVGVCLLGDKL 664
Query: 329 FICGGYNGEVILGDIWKLNLQTFQWVKL 356
+ GGY+G+ L + + QT +W ++
Sbjct: 665 YAVGGYDGQAYLNTVEAYDPQTNEWTQV 692
Score = 43.9 bits (102), Expect = 3e-04
Identities = 36/167 (21%), Positives = 64/167 (38%), Gaps = 17/167 (10%)
Query: 133 RYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYK 192
+Y T +W + M + + + L V GG G N V N K K
Sbjct: 440 KYDLRTNMWTPVAN---MNGRRLQFGVAVLDDKLYVVGGRD---GLKTLNTVECYNPKTK 493
Query: 193 RWALLSCRGKKPSRIYGQAMAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKPNNL 252
W+++ + +G +A++ G +Y GG G+ Y + + D R+W N
Sbjct: 494 TWSVMP---PMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQW------NF 544
Query: 253 SCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAW 299
+ R +A ++Y +GG + L + ++ TN W
Sbjct: 545 VATMSTPRSTVGVAVLSGKLYAVGGRDG--SSCLKSVECFDPHTNKW 589
Score = 32.0 bits (71), Expect = 1.2
Identities = 13/38 (34%), Positives = 18/38 (47%)
Query: 212 MAIINGSLYVFGGTTGYIYSTDLHKLDLNTREWTQLKP 249
+ ++ LY GG G Y + D T EWTQ+ P
Sbjct: 657 VCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAP 694
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.461
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,767,639
Number of Sequences: 37866
Number of extensions: 1141647
Number of successful extensions: 21250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 422
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 9389
Number of HSP's gapped (non-prelim): 6109
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.