Guide to the Human Genome
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Search of human proteins with 41327712

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
         (304 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ...   627   e-180
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ...   415   e-116
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik...   345   2e-95
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                 91   2e-18
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    82   4e-16
gi|39930351 dynamin binding protein [Homo sapiens]                     67   3e-11
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]          63   3e-10
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]          63   3e-10
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]     62   8e-10
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H...    57   2e-08
gi|11321634 CD2-associated protein [Homo sapiens]                      55   6e-08
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ...    55   1e-07
gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo ...    55   1e-07
gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo ...    55   1e-07
gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo ...    55   1e-07
gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo ...    55   1e-07
gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo ...    55   1e-07
gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo s...    55   1e-07
gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo ...    55   1e-07
gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]                   55   1e-07
gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]                   55   1e-07
gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]                   55   1e-07
gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]                    55   1e-07
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa...    54   2e-07
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s...    54   2e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...    54   2e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...    54   2e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...    54   2e-07
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]        53   3e-07
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]              52   5e-07

>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
           [Homo sapiens]
          Length = 304

 Score =  627 bits (1617), Expect = e-180
 Identities = 304/304 (100%), Positives = 304/304 (100%)

Query: 1   MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
           MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1   MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60

Query: 61  IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
           IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61  IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120

Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
           SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180

Query: 181 MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA 240
           MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA
Sbjct: 181 MIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYA 240

Query: 241 RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD 300
           RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD
Sbjct: 241 RVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPD 300

Query: 301 EDFS 304
           EDFS
Sbjct: 301 EDFS 304


>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
           [Homo sapiens]
          Length = 204

 Score =  415 bits (1066), Expect = e-116
 Identities = 203/203 (100%), Positives = 203/203 (100%)

Query: 1   MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
           MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY
Sbjct: 1   MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60

Query: 61  IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120
           IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR
Sbjct: 61  IINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR 120

Query: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180
           SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG
Sbjct: 121 SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRG 180

Query: 181 MIPVPYVEKYRPASASVSALIGG 203
           MIPVPYVEKYRPASASVSALIGG
Sbjct: 181 MIPVPYVEKYRPASASVSALIGG 203


>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
           [Homo sapiens]
          Length = 303

 Score =  345 bits (886), Expect = 2e-95
 Identities = 184/323 (56%), Positives = 217/323 (67%), Gaps = 45/323 (13%)

Query: 2   AGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYI 61
           +  FDS +RS+WY G +SRQEA   LQGQRHG+FLVRDSST PGDYVLSVSENSRVSHYI
Sbjct: 3   SARFDSSDRSAWYMGPVSRQEAQTRLQGQRHGMFLVRDSSTCPGDYVLSVSENSRVSHYI 62

Query: 62  INSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSR- 120
           INS   R                 R +IGDQEFD LPALLEFYKIHYLDTTTLIEP  R 
Sbjct: 63  INSLPNR-----------------RFKIGDQEFDHLPALLEFYKIHYLDTTTLIEPAPRY 105

Query: 121 ------SRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
                 S     +   ++  EYVR L+DF GND EDLPFKKG+IL I +KPEEQWW+A +
Sbjct: 106 PSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWSARN 165

Query: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPG-PYAQPSVNTPLP-- 231
            +G+ GMIPVPYVEK   +S        G     +    G PEP   YAQP   TPLP  
Sbjct: 166 KDGRVGMIPVPYVEKLVRSSPH------GKHGNRNSNSYGIPEPAHAYAQPQTTTPLPAV 219

Query: 232 ------------NLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGEC 279
                       + QNGP++A+ IQKRVP AYDKTALALEVG++VKVT++N++GQWEGE 
Sbjct: 220 SGSPGAAITPLPSTQNGPVFAKAIQKRVPCAYDKTALALEVGDIVKVTRMNINGQWEGEV 279

Query: 280 NGKRGHFPFTHVRLLDQQNPDED 302
           NG++G FPFTHV++ D QNPDE+
Sbjct: 280 NGRKGLFPFTHVKIFDPQNPDEN 302


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 52/177 (29%), Positives = 92/177 (51%), Gaps = 24/177 (13%)

Query: 13  WYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPV 71
           WY GR+SRQ A  +L  + H G FL+R+S +SPG++ +SV+   +V H+ +         
Sbjct: 60  WYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLRE------ 113

Query: 72  PPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQ 131
                      +  +  + +++F+SL  L++FY+     TTT+ +      +    +L+ 
Sbjct: 114 -----------ASGKYFLWEEKFNSLNELVDFYR-----TTTIAKKRQIFLRDEEPLLKS 157

Query: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
             A + +A FDF+  D   L F++GDI+ + ++P+  WW    S G+ G  P  YV+
Sbjct: 158 PGACFAQAQFDFSAQDPSQLSFRRGDIIEVLERPDPHWWRGR-SCGRVGFFPRSYVQ 213



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 17/49 (34%), Positives = 27/49 (55%)

Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
           AL+ F   + ++L F KGD L+I +  ++Q W   +  G  G IP  Y+
Sbjct: 5   ALYSFQATESDELAFNKGDTLKILNMEDDQNWYKAELRGVEGFIPKNYI 53


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 82.4 bits (202), Expect = 4e-16
 Identities = 53/190 (27%), Positives = 94/190 (49%), Gaps = 36/190 (18%)

Query: 4   NFDSEERSSWYWGRLSRQEAVALLQGQRH-GVFLVRDSSTSPGDYVLSVSENSRVSHYII 62
           N+   +   W++G++ R +A  +L  QRH G FL+R+S ++PGD+ LSV   + V H+ +
Sbjct: 51  NYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKV 110

Query: 63  NSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSR 122
              G                   +  +   +F+SL  L+++++            VSR++
Sbjct: 111 LRDGA-----------------GKYFLWVVKFNSLNELVDYHRS---------TSVSRNQ 144

Query: 123 QGSGVILRQ-----EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
           Q   + LR      ++  YV+ALFDF+  ++ +L F++GD + + D  +  WW      G
Sbjct: 145 Q---IFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGA-CHG 200

Query: 178 KRGMIPVPYV 187
           + GM P  YV
Sbjct: 201 QTGMFPRNYV 210



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 19/50 (38%), Positives = 31/50 (62%)

Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
           A +DF    +++L FK+GDIL++ ++  +Q W   +  GK G IP  Y+E
Sbjct: 5   AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIE 54


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 55/192 (28%), Positives = 82/192 (42%), Gaps = 21/192 (10%)

Query: 119 SRSRQGSGVILRQEEAEY----VRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
           S+SRQ        +  EY     RAL   +   +E+L F++GD++ I   PE  W+  E 
Sbjct: 128 SQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGE- 186

Query: 175 SEGKRGMIPVPYVEKYRPASASVSALIGGNQE-----GSHPQPLGGPEPGPYAQPSVNTP 229
            EG+RG+ P  +VE   P      ++  GNQ+     G    P+G  E G    P  +  
Sbjct: 187 LEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIG----PDEDEE 242

Query: 230 LPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFT 289
            P      +Y    Q   PN  D      EVG+ +++      G  EG   G+ G FP+ 
Sbjct: 243 EPGTYGVALYR--FQALEPNELD-----FEVGDKIRILATLEDGWLEGSLKGRTGIFPYR 295

Query: 290 HVRLLDQQNPDE 301
            V+L      +E
Sbjct: 296 FVKLCPDTRVEE 307



 Score = 35.0 bits (79), Expect = 0.082
 Identities = 42/164 (25%), Positives = 59/164 (35%), Gaps = 42/164 (25%)

Query: 132 EEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYR 191
           E    VRA+FDF  +  E+LP   GDI+ +    +E +W     E   G  P  +VE   
Sbjct: 2   EAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDE-FWLLGKKEDVTGQFPSSFVE--- 57

Query: 192 PASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAY 251
                                                 +P+L+ G      I +      
Sbjct: 58  -----------------------------------IVTIPSLKEGERLFVCICEFTSQEL 82

Query: 252 DKTALALEVGELVKVTKINVSGQWEG-ECNGKRGHFPFTHVRLL 294
           D   L L  G+LV +  I  +G  +G  C G RG FP + VR L
Sbjct: 83  DN--LPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVREL 124



 Score = 34.7 bits (78), Expect = 0.11
 Identities = 37/166 (22%), Positives = 62/166 (37%), Gaps = 27/166 (16%)

Query: 129 LRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVE 188
           L++ E  +V  + +F   + ++LP  +GD++ +   P   W       G RG  P   V 
Sbjct: 64  LKEGERLFV-CICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVR 122

Query: 189 KYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVP 248
           +   +S S                        +   S    +P    G   AR +     
Sbjct: 123 ELCLSSQS----------------------RQWHSQSALFQIPEYSMG--QARALMGL-- 156

Query: 249 NAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLL 294
           +A     L    G+++ +  +   G +EGE  G+RG FP   V LL
Sbjct: 157 SAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202


>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
          Length = 1291

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)

Query: 6   DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
           ++ E   WY   L+R +A   L++  R G FLVR  +  P  Y +S     ++ H  +  
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719

Query: 65  SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
            G                    + +G+ EFDSL  L+ +Y         K+ Y      +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761

Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
           E +  +    G +       +             V+ALFD+    E++L F K  I++  
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821

Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
           +K E  WW  +    K+   P  YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848



 Score = 36.2 bits (82), Expect = 0.037
 Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)

Query: 3   GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
           GN D EE               W+ G+L      R  A  LL       G   G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587

Query: 40  SSTSPGDYVLSVSENSRVSHYIINS 64
           S T  GDY LS   N +V H  I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612


>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
          Length = 1290

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 49/207 (23%), Positives = 81/207 (39%), Gaps = 42/207 (20%)

Query: 6   DSEERSSWYWGRLSRQEAV-ALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINS 64
           ++ E   WY   L+R +A   L++  R G FLVR  +  P  Y +S     ++ H  +  
Sbjct: 661 NAHESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRN-EPNSYAISFRAEGKIKHCRVQQ 719

Query: 65  SGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY---------KIHYLDTTTLI 115
            G                    + +G+ EFDSL  L+ +Y         K+ Y      +
Sbjct: 720 EG------------------QTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEAL 761

Query: 116 EPVSRSRQGSGVILRQEEAEY-------------VRALFDFNGNDEEDLPFKKGDILRIR 162
           E +  +    G +       +             V+ALFD+    E++L F K  I++  
Sbjct: 762 EKIGTAEPDYGALYEGRNPGFYVEANPMPTFKCAVKALFDYKAQREDELTFIKSAIIQNV 821

Query: 163 DKPEEQWWNAEDSEGKRGMIPVPYVEK 189
           +K E  WW  +    K+   P  YVE+
Sbjct: 822 EKQEGGWWRGDYGGKKQLWFPSNYVEE 848



 Score = 36.2 bits (82), Expect = 0.037
 Identities = 30/85 (35%), Positives = 35/85 (41%), Gaps = 23/85 (27%)

Query: 3   GNFDSEE------------RSSWYWGRLS-----RQEAVALLQ------GQRHGVFLVRD 39
           GN D EE               W+ G+L      R  A  LL       G   G FLVR+
Sbjct: 528 GNEDEEEPKEVSSSTELHSNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPDGSFLVRE 587

Query: 40  SSTSPGDYVLSVSENSRVSHYIINS 64
           S T  GDY LS   N +V H  I+S
Sbjct: 588 SETFVGDYTLSFWRNGKVQHCRIHS 612


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score = 61.6 bits (148), Expect = 8e-10
 Identities = 54/192 (28%), Positives = 80/192 (41%), Gaps = 38/192 (19%)

Query: 13  WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVP 72
           WY G + R  A ++L  +  G FLVR       ++ +S+  N  V H  I ++       
Sbjct: 671 WYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAISIKYNVEVKHIKIMTA------- 723

Query: 73  PSPAQPPPGVSPSRLRIGDQE-FDSLPALLEFYK-------IHYLDTTTLI---EP---- 117
                          RI +++ F  L  L+EFY+          LDTT      EP    
Sbjct: 724 -----------EGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEPEKRT 772

Query: 118 VSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEG 177
           +SR   GS       +A Y     DF   D  +L  K+GDI++I +K  +Q W   +  G
Sbjct: 773 ISRPAVGSTKYFGTAKARY-----DFCARDRSELSLKEGDIIKILNKKGQQGWWRGEIYG 827

Query: 178 KRGMIPVPYVEK 189
           + G  P  YVE+
Sbjct: 828 RVGWFPANYVEE 839



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 9/56 (16%)

Query: 250 AYDKTALALEVGELVKV-TKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
           A D++ L+L+ G+++K+  K    G W GE  G+ G FP  +V        +ED+S
Sbjct: 795 ARDRSELSLKEGDIIKILNKKGQQGWWRGEIYGRVGWFPANYV--------EEDYS 842


>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
           sapiens]
          Length = 756

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 54/201 (26%), Positives = 85/201 (42%), Gaps = 46/201 (22%)

Query: 114 LIEPVSRSRQGSGVILRQEEAE-------------YVRALFDFNGNDEEDLPFKKGDILR 160
           L++ +  + +GSG   R   A              + +  F ++    ++L  + G+I+ 
Sbjct: 52  LVQEIPETLRGSGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVE 111

Query: 161 IRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE--- 217
           +  + E+ WW  + + G+ G  P  +VE                   S P  LG P+   
Sbjct: 112 MIKEIEDGWWLGKKN-GQLGAFPSNFVELL----------------DSGPPSLGNPDMPS 154

Query: 218 --PGPYAQPSVNT-----PLPNLQ--NGPIYARVIQKRVPNAYDKTALALEVGELVKVTK 268
             PGP   P +++     P   LQ  + P   RV+    P A D+  LAL  G++VKV  
Sbjct: 155 VSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDE--LALRRGDVVKVLS 212

Query: 269 INVS--GQWEGECNGKRGHFP 287
                 G WEGEC G+RG FP
Sbjct: 213 KTTEDKGWWEGECQGRRGVFP 233



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/167 (26%), Positives = 67/167 (40%), Gaps = 28/167 (16%)

Query: 137 VRALFDFNGNDEEDLPFKKGDILR-IRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASA 195
           V  L  +    E++L    GD++R +R  P   W   E   G+ G+ P   V++      
Sbjct: 3   VLVLAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFG-GRYGLFPERLVQE------ 55

Query: 196 SVSALIGGNQEGSHPQPL---GGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYD 252
            +   + G+ E   P+     G P   P  Q               + +V     P   D
Sbjct: 56  -IPETLRGSGEARRPRCARRRGHPAKHPRPQR--------------WCKVNFSYSPEQAD 100

Query: 253 KTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNP 299
           +  L L+ GE+V++ K    G W G+ NG+ G FP   V LLD   P
Sbjct: 101 E--LKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPP 145


>gi|11321634 CD2-associated protein [Homo sapiens]
          Length = 639

 Score = 55.5 bits (132), Expect = 6e-08
 Identities = 41/175 (23%), Positives = 82/175 (46%), Gaps = 24/175 (13%)

Query: 141 FDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY---------- 190
           +D++   +++L  + G+I+R   K +E+ W   +  G+RGM P  +V++           
Sbjct: 8   YDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67

Query: 191 ----RPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKR 246
               R    +V++L+   +  ++  P GG +P P  + ++       Q      +V+ + 
Sbjct: 68  LPIKRERHGNVASLV--QRISTYGLPAGGIQPHPQTK-NIKKKTKKRQ-----CKVLFEY 119

Query: 247 VPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDE 301
           +P   D+  L L+VG+++ + +    G W G  N K G FP   V+ L+  +  E
Sbjct: 120 IPQNEDE--LELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGE 172



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRI--RDKPEEQWWNAEDSEGKRGMIP 183
           EY R LF + G +E++L FK+G+I+ +  ++  E  WW  E   GK G+ P
Sbjct: 272 EYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRGE-LNGKEGVFP 321



 Score = 39.3 bits (90), Expect = 0.004
 Identities = 18/62 (29%), Positives = 35/62 (56%), Gaps = 1/62 (1%)

Query: 128 ILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
           I ++ +    + LF++   +E++L  K GDI+ I ++ EE WW+      K G+ P  +V
Sbjct: 104 IKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSG-TLNNKLGLFPSNFV 162

Query: 188 EK 189
           ++
Sbjct: 163 KE 164



 Score = 37.0 bits (84), Expect = 0.022
 Identities = 19/50 (38%), Positives = 30/50 (60%), Gaps = 1/50 (2%)

Query: 256 LALEVGELVK-VTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS 304
           L + VGE+++ V K+   G  EGE NG+RG FP   V+ + ++   +D S
Sbjct: 18  LTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDS 67



 Score = 28.9 bits (63), Expect = 5.9
 Identities = 16/43 (37%), Positives = 23/43 (53%), Gaps = 5/43 (11%)

Query: 250 AYDKT---ALALEVGELVKVT--KINVSGQWEGECNGKRGHFP 287
           AY+ T    L  + GE++ +   +   +G W GE NGK G FP
Sbjct: 279 AYEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFP 321


>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
           sapiens]
          Length = 492

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 247 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 301

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 302 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 332

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 333 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 389



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 412 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 463

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 464 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 491


>gi|224586853 sorbin and SH3 domain containing 2 isoform 7 [Homo
           sapiens]
          Length = 1004

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 759 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 813

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 814 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 844

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 845 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 901



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105  KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
            +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 924  RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 975

Query: 163  DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
            +K ++ W+       K  G  P  YV++
Sbjct: 976  EKCDDGWFVGTSRRTKFFGTFPGNYVKR 1003


>gi|224586851 sorbin and SH3 domain containing 2 isoform 6 [Homo
           sapiens]
          Length = 824

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 579 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 633

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 634 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 664

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 665 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 721



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 744 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 795

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 796 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 823


>gi|224586849 sorbin and SH3 domain containing 2 isoform 5 [Homo
           sapiens]
          Length = 661

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 416 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 470

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 471 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 501

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 502 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 558



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 581 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 632

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 633 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 660


>gi|224586846 sorbin and SH3 domain containing 2 isoform 4 [Homo
           sapiens]
          Length = 731

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 486 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 540

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 541 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 571

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 572 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 628



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 651 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 702

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 703 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 730


>gi|224586844 sorbin and SH3 domain containing 2 isoform 3 [Homo
           sapiens]
          Length = 644

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 399 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 453

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 454 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 484

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 485 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 541



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 564 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 615

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 616 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 643


>gi|10947118 sorbin and SH3 domain containing 2 isoform 2 [Homo
           sapiens]
          Length = 1100

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 855 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 909

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 910 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 940

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 941 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 997



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105  KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
            +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 1020 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 1071

Query: 163  DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
            +K ++ W+       K  G  P  YV++
Sbjct: 1072 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 1099


>gi|194733749 sorbin and SH3 domain containing 2 isoform 1 [Homo
           sapiens]
          Length = 666

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 51/177 (28%), Positives = 79/177 (44%), Gaps = 36/177 (20%)

Query: 120 RSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR 179
           R R+G+     ++E    +A++DF     ++L FKKGD + I  K ++ W+  E   G+ 
Sbjct: 421 RERRGTP----EKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGE-HHGRV 475

Query: 180 GMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIY 239
           G+ P+ YVEK  P                       PE    AQP+   P P  Q G I 
Sbjct: 476 GIFPISYVEKLTP-----------------------PEK---AQPA--RPPPPAQPGEI- 506

Query: 240 ARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNG--KRGHFPFTHVRLL 294
              I K   NA     L+L  G+ V + K      +EG+  G  ++G FP ++V ++
Sbjct: 507 GEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVV 563



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 21/88 (23%), Positives = 42/88 (47%), Gaps = 11/88 (12%)

Query: 105 KIHYLDTTTLIEPV--SRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIR 162
           +IH L +     PV    + QG G        E  +AL+++   +E++L  ++ D++ + 
Sbjct: 586 RIHSLSSNKPQRPVFTHENIQGGG--------EPFQALYNYTPRNEDELELRESDVIDVM 637

Query: 163 DKPEEQWWNAEDSEGK-RGMIPVPYVEK 189
           +K ++ W+       K  G  P  YV++
Sbjct: 638 EKCDDGWFVGTSRRTKFFGTFPGNYVKR 665


>gi|189491778 nephrocystin 1 isoform 4 [Homo sapiens]
          Length = 614

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 94  EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 152

Query: 195 ASVSALIGGNQE 206
               +   G++E
Sbjct: 153 EGQESSEEGSEE 164


>gi|189491776 nephrocystin 1 isoform 3 [Homo sapiens]
          Length = 677

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214

Query: 195 ASVSALIGGNQE 206
               +   G++E
Sbjct: 215 EGQESSEEGSEE 226


>gi|189491774 nephrocystin 1 isoform 2 [Homo sapiens]
          Length = 732

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214

Query: 195 ASVSALIGGNQE 206
               +   G++E
Sbjct: 215 EGQESSEEGSEE 226


>gi|46397398 nephrocystin 1 isoform 1 [Homo sapiens]
          Length = 733

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 26/72 (36%), Positives = 41/72 (56%), Gaps = 1/72 (1%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPAS 194
           EY+ A+ DF      DL FKKG+IL + +K  + WW A+D++G  G++P  Y+E Y    
Sbjct: 156 EYI-AVGDFTAQQVGDLTFKKGEILLVIEKKPDGWWIAKDAKGNEGLVPRTYLEPYSEEE 214

Query: 195 ASVSALIGGNQE 206
               +   G++E
Sbjct: 215 EGQESSEEGSEE 226


>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 816

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 53/259 (20%)

Query: 38  RDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSL 97
           R+S  +PGD  L+  EN R  +  +   G  P    S  + P   + ++     + F  +
Sbjct: 501 RESDGAPGD--LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHF--I 556

Query: 98  PALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGD 157
           PA        YL++T   E   R R         +E    RA FDF     ++LP +KGD
Sbjct: 557 PA-------DYLEST---EEFIRRRHDD------KEMRPARAKFDFKAQTLKELPLQKGD 600

Query: 158 ILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE 217
           I+ I  + ++ W+  E   G+ G+ P  Y+E   PA                        
Sbjct: 601 IVYIYKQIDQNWYEGE-HHGRVGIFPRTYIELLPPAEK---------------------- 637

Query: 218 PGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEG 277
               AQP   TP+  L+    Y   I K   N   +  ++   GE + + +      +EG
Sbjct: 638 ----AQPKKLTPVQVLE----YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 689

Query: 278 ECNG--KRGHFPFTHVRLL 294
              G  ++G FP T+V ++
Sbjct: 690 RIPGTSRQGIFPITYVDVI 708



 Score = 28.5 bits (62), Expect = 7.7
 Identities = 13/52 (25%), Positives = 29/52 (55%), Gaps = 1/52 (1%)

Query: 138 RALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR-GMIPVPYVE 188
           +AL+ +   ++++L  + GDI+ + +K ++ W+       K+ G  P  YV+
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812


>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 684

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 64/259 (24%), Positives = 103/259 (39%), Gaps = 53/259 (20%)

Query: 38  RDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSL 97
           R+S  +PGD  L+  EN R  +  +   G  P    S  + P   + ++     + F  +
Sbjct: 369 RESDGAPGD--LTSLENERQIYKSVLEGGDIPLQGLSGLKRPSSSASTKDSESPRHF--I 424

Query: 98  PALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGD 157
           PA        YL++T   E   R R         +E    RA FDF     ++LP +KGD
Sbjct: 425 PA-------DYLEST---EEFIRRRHDD------KEMRPARAKFDFKAQTLKELPLQKGD 468

Query: 158 ILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPE 217
           I+ I  + ++ W+  E   G+ G+ P  Y+E   PA                        
Sbjct: 469 IVYIYKQIDQNWYEGE-HHGRVGIFPRTYIELLPPAEK---------------------- 505

Query: 218 PGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEG 277
               AQP   TP+  L+    Y   I K   N   +  ++   GE + + +      +EG
Sbjct: 506 ----AQPKKLTPVQVLE----YGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEG 557

Query: 278 ECNG--KRGHFPFTHVRLL 294
              G  ++G FP T+V ++
Sbjct: 558 RIPGTSRQGIFPITYVDVI 576



 Score = 28.5 bits (62), Expect = 7.7
 Identities = 13/52 (25%), Positives = 29/52 (55%), Gaps = 1/52 (1%)

Query: 138 RALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKR-GMIPVPYVE 188
           +AL+ +   ++++L  + GDI+ + +K ++ W+       K+ G  P  YV+
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 26/48 (54%), Positives = 32/48 (66%)

Query: 13  WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
           W+ G++S QEAV  LQ    G+FLVR+S+  PGDYVL VS    V HY
Sbjct: 81  WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 128


>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 26/48 (54%), Positives = 32/48 (66%)

Query: 13  WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
           W+ G++S QEAV  LQ    G+FLVR+S+  PGDYVL VS    V HY
Sbjct: 123 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 170


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 26/48 (54%), Positives = 32/48 (66%)

Query: 13  WYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHY 60
           W+ G++S QEAV  LQ    G+FLVR+S+  PGDYVL VS    V HY
Sbjct: 122 WFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHY 169


>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
          Length = 882

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 37/129 (28%), Positives = 56/129 (43%), Gaps = 5/129 (3%)

Query: 64  SSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQ 123
           S G  PP  P P Q     +P+    G     S P    F       T   +  ++ SR 
Sbjct: 130 SPGGSPPARPIPGQ---SAAPTLAGGGGGAAGSTPGSPVFLSAAAGSTAGSLRELATSRT 186

Query: 124 GSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIP 183
                       Y +AL+ + G +  DL F KGDI+ +R K +EQW++ E   G +G +P
Sbjct: 187 APAA-KNPCLLPYGKALYSYEGKEPGDLKFNKGDIIVLRRKVDEQWYHGE-LHGTQGFLP 244

Query: 184 VPYVEKYRP 192
             Y++  +P
Sbjct: 245 ASYIQCIQP 253



 Score = 33.5 bits (75), Expect = 0.24
 Identities = 15/57 (26%), Positives = 28/57 (49%), Gaps = 1/57 (1%)

Query: 135 EYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAE-DSEGKRGMIPVPYVEKY 190
           E  R +  +    E ++  K+GDI+ +  K E+ W+       G+ G+ P  +VE +
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLFPGSFVESF 882



 Score = 28.9 bits (63), Expect = 5.9
 Identities = 19/77 (24%), Positives = 32/77 (41%), Gaps = 1/77 (1%)

Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWW-NAEDSEGKRGMIPVPYVEKYRPASASV 197
           AL+ +     ++L   KG++ R+ +K ++ W+  A    G  G+ P  YV       A  
Sbjct: 471 ALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGG 530

Query: 198 SALIGGNQEGSHPQPLG 214
           +     N  G  P   G
Sbjct: 531 AGPPRNNVVGGSPLAKG 547


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score = 52.4 bits (124), Expect = 5e-07
 Identities = 27/60 (45%), Positives = 37/60 (61%)

Query: 6   DSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSS 65
           +S E+ SWY G +SR  A  LL    +G FLVR+S +SPG   +S+    RV HY IN++
Sbjct: 151 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210



 Score = 30.4 bits (67), Expect = 2.0
 Identities = 14/49 (28%), Positives = 25/49 (51%)

Query: 139 ALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYV 187
           AL+DF  + +  L   KG+ LR+    +   W+   S+  +G +P  Y+
Sbjct: 99  ALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSNYI 147


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.135    0.409 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,795,454
Number of Sequences: 37866
Number of extensions: 884675
Number of successful extensions: 9380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 340
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 7254
Number of HSP's gapped (non-prelim): 2029
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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