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Search of human proteins with 40549433
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40549433 transmembrane phosphatase with tensin homology
isoform beta [Homo sapiens]
(533 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40549433 transmembrane phosphatase with tensin homology isofo... 1065 0.0
gi|109689707 transmembrane phosphatase with tensin homology isof... 1054 0.0
gi|40549435 transmembrane phosphatase with tensin homology isofo... 1016 0.0
gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase... 883 0.0
gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase... 719 0.0
gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase... 620 e-178
gi|73765544 phosphatase and tensin homolog [Homo sapiens] 206 6e-53
gi|66529407 tensin [Homo sapiens] 124 2e-28
gi|65288071 tensin 3 [Homo sapiens] 122 1e-27
gi|157384971 cyclin G associated kinase [Homo sapiens] 119 7e-27
gi|38787970 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|38787957 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|38787941 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|239756009 PREDICTED: similar to transmembrane phosphoinositid... 103 3e-22
gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo sap... 97 3e-20
gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens] 65 2e-10
gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens] 65 2e-10
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 47 6e-05
gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens] 45 2e-04
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 43 8e-04
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 43 8e-04
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 43 8e-04
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 43 8e-04
gi|205277447 dual specificity phosphatase 11 [Homo sapiens] 42 0.002
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 41 0.002
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa... 41 0.002
gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa... 41 0.002
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 40 0.005
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 40 0.005
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 40 0.005
>gi|40549433 transmembrane phosphatase with tensin homology isoform
beta [Homo sapiens]
Length = 533
Score = 1065 bits (2754), Expect = 0.0
Identities = 533/533 (100%), Positives = 533/533 (100%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
Query: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL
Sbjct: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
Query: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 180
MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR
Sbjct: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 180
Query: 181 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
Sbjct: 181 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
Query: 241 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 300
FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF
Sbjct: 241 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 300
Query: 301 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 360
TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH
Sbjct: 301 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 360
Query: 361 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 420
SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME
Sbjct: 361 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 420
Query: 421 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 480
KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL
Sbjct: 421 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 480
Query: 481 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 533
HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD
Sbjct: 481 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 533
>gi|109689707 transmembrane phosphatase with tensin homology isoform
alpha [Homo sapiens]
Length = 551
Score = 1054 bits (2725), Expect = 0.0
Identities = 533/551 (96%), Positives = 533/551 (96%), Gaps = 18/551 (3%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES------------------VL 42
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES VL
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVL 60
Query: 43 ARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL 102
ARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL
Sbjct: 61 ARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL 120
Query: 103 YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD 162
YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD
Sbjct: 121 YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD 180
Query: 163 IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT 222
IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT
Sbjct: 181 IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT 240
Query: 223 YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV 282
YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV
Sbjct: 241 YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV 300
Query: 283 RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS 342
RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS
Sbjct: 301 RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS 360
Query: 343 TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI 402
TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI
Sbjct: 361 TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI 420
Query: 403 IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF 462
IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF
Sbjct: 421 IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF 480
Query: 463 FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 522
FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK
Sbjct: 481 FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 540
Query: 523 MTSSDVVAGSD 533
MTSSDVVAGSD
Sbjct: 541 MTSSDVVAGSD 551
>gi|40549435 transmembrane phosphatase with tensin homology isoform
gamma [Homo sapiens]
Length = 513
Score = 1016 bits (2627), Expect = 0.0
Identities = 513/533 (96%), Positives = 513/533 (96%), Gaps = 20/533 (3%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES-------------------- 40
Query: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL
Sbjct: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
Query: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 180
MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR
Sbjct: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 160
Query: 181 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
Sbjct: 161 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 220
Query: 241 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 300
FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF
Sbjct: 221 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 280
Query: 301 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 360
TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH
Sbjct: 281 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 340
Query: 361 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 420
SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME
Sbjct: 341 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 400
Query: 421 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 480
KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL
Sbjct: 401 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 460
Query: 481 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 533
HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD
Sbjct: 461 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 513
>gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase
isoform gamma [Homo sapiens]
Length = 522
Score = 883 bits (2281), Expect = 0.0
Identities = 442/522 (84%), Positives = 470/522 (90%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
MNESP + G E +SP TSEFKGA +P +S+L RLSKFEVEDAENVASYD
Sbjct: 1 MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYD 60
Query: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
SKIKKIVHSIVSSFAFG+FGVFLVLLDVTL+LADLIFTDSKLYIPLEYRSISLAI LFFL
Sbjct: 61 SKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFL 120
Query: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 180
MDVLLRVFVE RQQYFSDLFNILDTAIIVI LLVDV+YIFFDIKLLRNIPRWTHL+RLLR
Sbjct: 121 MDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLR 180
Query: 181 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
LIIL+RIFHL HQKRQLEKL+RR VSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
Sbjct: 181 LIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
Query: 241 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 300
FYRNPI+EVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRV RIMIDDHNVPTLH+MVVF
Sbjct: 241 FYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF 300
Query: 301 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 360
TKEVNEWMAQDLENIVAIHCKGG RTGTMVCA LIASEI TA+ESLYYFGERRT+KTH
Sbjct: 301 TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTH 360
Query: 361 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 420
S KFQGVETPSQ RYV YFAQVKHLYNWNLPPRRILFIK FIIYSI V DLK+Q+ ME
Sbjct: 361 SNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME 420
Query: 421 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 480
KKVVFS+ SLG CS+L +I TDKILI+V+DG PLYDDVKVQFF SNLP YYDNC F+FW
Sbjct: 421 KKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWF 480
Query: 481 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 522
+TSFI+NNRL LP+NELDN HKQKA +IYP +FAVEILFGEK
Sbjct: 481 NTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK 522
>gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase
isoform alpha [Homo sapiens]
Length = 445
Score = 719 bits (1856), Expect = 0.0
Identities = 373/503 (74%), Positives = 402/503 (79%), Gaps = 59/503 (11%)
Query: 20 NDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLF 79
N+SPQT+EFKG TEEAPAKES + S+ K ++VS + +F
Sbjct: 2 NESPQTNEFKGTTEEAPAKES-----------------PHTSEFKGA--ALVSPISKRIF 42
Query: 80 GVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDL 139
GVFLVLLDVTL+LADLIFTDSKLYIPLEYRSISLAI LFFLMDVLLRVFVE
Sbjct: 43 GVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVE--------- 93
Query: 140 FNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEK 199
WTHL+RLLRLIIL+RIFHL HQKRQLEK
Sbjct: 94 -------------------------------GWTHLVRLLRLIILIRIFHLLHQKRQLEK 122
Query: 200 LIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRN 259
L+RR VSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPI+EVVRFLDKKHRN
Sbjct: 123 LMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRN 182
Query: 260 HYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIH 319
HYRVYNLCSERAYDPKHFHNRV RIMIDDHNVPTLH+MVVFTKEVNEWMAQDLENIVAIH
Sbjct: 183 HYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIH 242
Query: 320 CKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYF 379
CKGG RTGTMVCA LIASEI TA+ESLYYFGERRT+KTHS KFQGVETPSQ RYV YF
Sbjct: 243 CKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYF 302
Query: 380 AQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNI 439
AQVKHLYNWNLPPRRILFIK FIIYSI V DLK+Q+ MEKKVVFS+ SLG CS+L +I
Sbjct: 303 AQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDI 362
Query: 440 TTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDN 499
TDKILI+V+DG PLYDDVKVQFF SNLP YYDNC F+FW +TSFI+NNRL LP+NELDN
Sbjct: 363 ETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDN 422
Query: 500 LHKQKARRIYPSDFAVEILFGEK 522
HKQKA +IYP +FAVEILFGEK
Sbjct: 423 PHKQKAWKIYPPEFAVEILFGEK 445
>gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase
isoform delta [Homo sapiens]
Length = 411
Score = 620 bits (1600), Expect = e-178
Identities = 303/364 (83%), Positives = 327/364 (89%), Gaps = 2/364 (0%)
Query: 161 FDIKLLRNIP--RWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFD 218
F+++ N+ WTHL+RLLRLIIL+RIFHL HQKRQLEKL+RR VSENKRRYTRDGFD
Sbjct: 48 FEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFD 107
Query: 219 LDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH 278
LDLTYVTERIIAMSFPSSGRQSFYRNPI+EVVRFLDKKHRNHYRVYNLCSERAYDPKHFH
Sbjct: 108 LDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH 167
Query: 279 NRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIAS 338
NRV RIMIDDHNVPTLH+MVVFTKEVNEWMAQDLENIVAIHCKGG RTGTMVCA LIAS
Sbjct: 168 NRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIAS 227
Query: 339 EICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFI 398
EI TA+ESLYYFGERRT+KTHS KFQGVETPSQ RYV YFAQVKHLYNWNLPPRRILFI
Sbjct: 228 EIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFI 287
Query: 399 KHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDV 458
K FIIYSI V DLK+Q+ MEKKVVFS+ SLG CS+L +I TDKILI+V+DG PLYDDV
Sbjct: 288 KRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDV 347
Query: 459 KVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEIL 518
KVQFF SNLP YYDNC F+FW +TSFI+NNRL LP+NELDN HKQKA +IYP +FAVEIL
Sbjct: 348 KVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEIL 407
Query: 519 FGEK 522
FGEK
Sbjct: 408 FGEK 411
Score = 69.7 bits (169), Expect = 6e-12
Identities = 35/60 (58%), Positives = 41/60 (68%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
MNESP + G E +SP TSEFKGA +P +S+L RLSKFEVEDAENVASY+
Sbjct: 1 MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYE 60
>gi|73765544 phosphatase and tensin homolog [Homo sapiens]
Length = 403
Score = 206 bits (523), Expect = 6e-53
Identities = 126/360 (35%), Positives = 194/360 (53%), Gaps = 56/360 (15%)
Query: 200 LIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRN 259
+I+ VS NKRRY DGFDLDLTY+ IIAM FP+ + YRN I +VVRFLD KH+N
Sbjct: 4 IIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKN 63
Query: 260 HYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIH 319
HY++YNLC+ER YD F+ RV + +DHN P L + F +++++W+++D ++ AIH
Sbjct: 64 HYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIH 123
Query: 320 CKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRT-DKTHSEKFQGVETPSQKRYVAY 378
CK G RTG M+CA+L+ A+E+L ++GE RT DK +GV PSQ+RYV Y
Sbjct: 124 CKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDK------KGVTIPSQRRYVYY 177
Query: 379 FAQVKHLYNWNLPPRRILFIKHFIIY-SIPRY----VRDLKIQIEMEKKVVFSTISLGKC 433
++ +L +L R + + H +++ +IP + + +++ K+ S +
Sbjct: 178 YS---YLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTR- 233
Query: 434 SVLDNITTDKILIDVF-DGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFI------- 485
DK + F LP+ D+KV+FF+ + F+FW++T FI
Sbjct: 234 ------REDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETS 287
Query: 486 ----------------------ENNRLY----LPKNELDNLHKQKARRIYPSDFAVEILF 519
+N++ Y L KN+LD +K KA R + +F V++ F
Sbjct: 288 EKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 124 bits (311), Expect = 2e-28
Identities = 90/313 (28%), Positives = 152/313 (48%), Gaps = 17/313 (5%)
Query: 211 RYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSER 270
R D +LDL YVTERIIA+SFPS+ + +R+ ++EV + L KH +Y ++NL SER
Sbjct: 5 RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SER 63
Query: 271 AYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTM 330
D H +V+ D + P L ++ K ++ W+ D N+V +H KG R G +
Sbjct: 64 RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVV 123
Query: 331 VCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWN 389
+ A++ S I ++A ++L F +R + +K + PSQ+RYV YF+ + N
Sbjct: 124 IAAYMHYSNISASADQALDRFAMKR---FYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMN 180
Query: 390 LPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTD---KILI 446
P LF+ H I++ IP + + + ++ + S + NI D + I
Sbjct: 181 NKP---LFLHHVIMHGIPNFESKGGCRPFLR---IYQAMQPVYTSGIYNIPGDSQTSVCI 234
Query: 447 DVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKAR 506
+ GL L D+ ++ ++ + + F HT I + + K +LD+ K
Sbjct: 235 TIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDR- 293
Query: 507 RIYPSDFAVEILF 519
+P VE +F
Sbjct: 294 --FPEYGKVEFVF 304
>gi|65288071 tensin 3 [Homo sapiens]
Length = 1445
Score = 122 bits (305), Expect = 1e-27
Identities = 88/323 (27%), Positives = 154/323 (47%), Gaps = 26/323 (8%)
Query: 215 DGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDP 274
+G LDLTY+TERIIA+SFP+ + Y + ++EV R L KH ++Y V NL SE+ YD
Sbjct: 3 EGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDL 61
Query: 275 KHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAF 334
+ +++ + + + P L +M K W+ +L+++V IHC+GG R G ++ ++
Sbjct: 62 TKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSY 121
Query: 335 LIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 393
+ + + ++A ++L F + K + +K + PSQKRYV + + + N P
Sbjct: 122 MHFTNVSASADQALDRFAMK---KFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASP- 177
Query: 394 RILFIKHFIIYSIPRYVRD------LKIQIEMEKKVVFSTISLGKCSVLDNITTDKILID 447
LF+ I++ P + LK+ M+ ++G +I I
Sbjct: 178 --LFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGP------ENPSRICIV 229
Query: 448 VFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARR 507
+ L DV V+ ++ + + F HT ++ L K +LDN K
Sbjct: 230 IEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDR-- 287
Query: 508 IYPSDFAVEILFG---EKMTSSD 527
+P VE++F EK+ S+
Sbjct: 288 -FPDYGKVELVFSATPEKIQGSE 309
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 119 bits (298), Expect = 7e-27
Identities = 63/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 218 DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 277
DLD++Y+T RI MSFP+ G +S +N I++V FLD KH HY VYNL S R Y P F
Sbjct: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
Query: 278 HNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA 337
HNRV P LH + + ++ W+ QD +N+ +HC G + VC+FL
Sbjct: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
Query: 338 SEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQV 382
+ STA+ ++Y F +R G+ PS KRY+ Y +
Sbjct: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
[Homo sapiens]
Length = 1285
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 217 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 276
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 5 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 63
Query: 277 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 336
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 64 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 123
Query: 337 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 393
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 124 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 177
Query: 394 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 450
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 178 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 232
Query: 451 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 510
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 233 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 289
Query: 511 SDFAVEILFGEKMTSSDVVAGS 532
+VE +F +S + + GS
Sbjct: 290 FQASVEFVFS---SSPEKIKGS 308
>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
[Homo sapiens]
Length = 1409
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 217 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 276
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 129 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 187
Query: 277 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 336
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 188 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 247
Query: 337 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 393
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 248 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 301
Query: 394 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 450
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 302 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 356
Query: 451 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 510
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 357 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 413
Query: 511 SDFAVEILFGEKMTSSDVVAGS 532
+VE +F +S + + GS
Sbjct: 414 FQASVEFVFS---SSPEKIKGS 432
>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
[Homo sapiens]
Length = 1419
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 217 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 276
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 139 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 197
Query: 277 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 336
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 198 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 257
Query: 337 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 393
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 258 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 311
Query: 394 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 450
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 312 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 366
Query: 451 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 510
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 367 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 423
Query: 511 SDFAVEILFGEKMTSSDVVAGS 532
+VE +F +S + + GS
Sbjct: 424 FQASVEFVFS---SSPEKIKGS 442
>gi|239756009 PREDICTED: similar to transmembrane phosphoinositide
3-phosphatase and tensin homolog 2, partial [Homo
sapiens]
Length = 99
Score = 103 bits (258), Expect = 3e-22
Identities = 47/55 (85%), Positives = 49/55 (89%)
Query: 269 ERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGG 323
ERAYDPKHFHNRV RIMIDDHNVPTL +MV F+KEV EWMAQD ENIV IHCKGG
Sbjct: 29 ERAYDPKHFHNRVSRIMIDDHNVPTLREMVAFSKEVLEWMAQDSENIVVIHCKGG 83
>gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo
sapiens]
Length = 913
Score = 97.4 bits (241), Expect = 3e-20
Identities = 57/180 (31%), Positives = 89/180 (49%), Gaps = 13/180 (7%)
Query: 204 RVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRV 263
RV ++ YT+ DLD TYVT RII MSFP +RN + ++ FLD +H +HY V
Sbjct: 51 RVIQSVTSYTKG--DLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTV 108
Query: 264 YNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGG 323
YNL S ++Y FH+RV P+LH + + + W+ Q+ +N+ +HC G
Sbjct: 109 YNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDG 167
Query: 324 TDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVE-TPSQKRYVAYFAQV 382
+ +V A I + ST ++ +R G+ +PS +RY+ Y +
Sbjct: 168 RAASSILVGAMFIFCNLYSTPGPAIRLLYAKR---------PGIGLSPSHRRYLGYMCDL 218
>gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 45/194 (23%)
Query: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSK 62
E P PT ++G E G +P + G AP
Sbjct: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLD------------------------ 87
Query: 63 IKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIA 116
+ ++ + SS F + + LV+LD L+LA+LI D Y + + +S+ I
Sbjct: 88 FRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITIL 147
Query: 117 LFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLL 176
+FF+M+++ ++FV R ++F F ILD ++V+ ++D+V +F + H
Sbjct: 148 VFFMMEIIFKLFV-FRLEFFHHKFEILDAVVVVVSFILDIVLLFQE-----------HQF 195
Query: 177 RLLRLIILLRIFHL 190
L L+ILLR++ +
Sbjct: 196 EALGLLILLRLWRV 209
>gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 64.7 bits (156), Expect = 2e-10
Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 45/194 (23%)
Query: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSK 62
E P PT ++G E G +P + G AP
Sbjct: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLD------------------------ 87
Query: 63 IKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIA 116
+ ++ + SS F + + LV+LD L+LA+LI D Y + + +S+ I
Sbjct: 88 FRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITIL 147
Query: 117 LFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLL 176
+FF+M+++ ++FV R ++F F ILD ++V+ ++D+V +F + H
Sbjct: 148 VFFMMEIIFKLFV-FRLEFFHHKFEILDAVVVVVSFILDIVLLFQE-----------HQF 195
Query: 177 RLLRLIILLRIFHL 190
L L+ILLR++ +
Sbjct: 196 EALGLLILLRLWRV 209
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 46.6 bits (109), Expect = 6e-05
Identities = 47/179 (26%), Positives = 88/179 (49%), Gaps = 16/179 (8%)
Query: 12 GVIIELGPNDSPQTSEFKGA----TEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIV 67
GVII+ N + Q +F G TEE + + +L + + + + +KI+ IV
Sbjct: 1461 GVIID---NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ--KPIPRPLNKIQGIV 1515
Query: 68 HSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRV 127
V+ AF + + L+ L++ ++ + T SK + Y I+L +FF + +L++
Sbjct: 1516 FDFVTQQAFDIVIMMLICLNMVTMMVETD-TQSKQMENILYW-INLVFVIFFTCECVLKM 1573
Query: 128 FVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLI 182
F R YF+ +NI D ++++ + L D++ +F L + R + R+LRLI
Sbjct: 1574 FA-LRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLI 1631
>gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]
Length = 1177
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 4/145 (2%)
Query: 65 KIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVL 124
+I H+IV + F G ++L+++ + I + +Y E + + ++++ L
Sbjct: 602 RICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHS-ELKHTNYCFLTLYILEAL 660
Query: 125 LRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIIL 184
L++ R+ +FS +NI + AI +I +L ++ IK + N +++++ +
Sbjct: 661 LKI-AAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRI 719
Query: 185 LRIFHLFHQKRQLEKLIRRRVSENK 209
LRIF L K L ++I +R+S K
Sbjct: 720 LRIFKLIAPK--LLQIIDKRMSHQK 742
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 42.7 bits (99), Expect = 8e-04
Identities = 32/126 (25%), Positives = 69/126 (54%), Gaps = 7/126 (5%)
Query: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
+KI+ +V+ +V+ AF + + L+ L++ ++ + S+L + + Y +I++ + F
Sbjct: 1340 NKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETD-NQSQLKVDILY-NINMIFIIIFT 1397
Query: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLL 176
+ +L++ RQ YF+ +NI D ++++ L L D++ +F L + R +
Sbjct: 1398 GECVLKMLA-LRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLARIG 1456
Query: 177 RLLRLI 182
R+LRLI
Sbjct: 1457 RVLRLI 1462
Score = 29.3 bits (64), Expect = 9.4
Identities = 41/185 (22%), Positives = 73/185 (39%), Gaps = 18/185 (9%)
Query: 19 PNDSPQTSEFKGATEEAPAK---ESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFA 75
P + P+ + E P + E+ + R V+ ++ +++ IV
Sbjct: 973 PEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNW 1032
Query: 76 FGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQY 135
F F VF++LL + + I+ + + I F+M++LL+ + Y
Sbjct: 1033 FETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVY 1092
Query: 136 FSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHL-----LRLLRLIILLRIFHL 190
F++ + LD L+VDV I L+ N ++ L LR LR + LR
Sbjct: 1093 FTNAWCWLD------FLIVDVSI----ISLVANWLGYSELGPIKSLRTLRALRPLRALSR 1142
Query: 191 FHQKR 195
F R
Sbjct: 1143 FEGMR 1147
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 42.7 bits (99), Expect = 8e-04
Identities = 41/180 (22%), Positives = 80/180 (44%), Gaps = 7/180 (3%)
Query: 24 QTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD--SKIKKIVHSIVSSFAFGLFGV 81
Q +E EE + R S F +A+ Y S ++ +HS+ +S LF
Sbjct: 1565 QEAEEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFIT 1624
Query: 82 FLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFN 141
F++ ++V + + L L+Y + I F + L F RR +F D +N
Sbjct: 1625 FIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRR--FFKDRWN 1682
Query: 142 ILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLI 201
LD AI+++ L+ + +I++ +P ++R++R++ + R+ L + L+
Sbjct: 1683 QLDLAIVLLSLMGITLE---EIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALL 1739
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 42.7 bits (99), Expect = 8e-04
Identities = 38/192 (19%), Positives = 93/192 (48%), Gaps = 12/192 (6%)
Query: 12 GVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDS--KIKKIVHS 69
GV++E + + + + A E +E L RL K + A+ + Y + + ++HS
Sbjct: 1393 GVVVE----NFHKCRQHQEAEEARRREEKRLRRLEK-KRRKAQRLPYYATYCHTRLLIHS 1447
Query: 70 IVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFV 129
+ +S +F F++ L+V + + + L L+Y + F+++ +L++
Sbjct: 1448 MCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY--CNYMFTTVFVLEAVLKLVA 1505
Query: 130 ERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFH 189
+++F D +N LD AI+++ ++ + +I++ +P ++R++R++ + R+
Sbjct: 1506 FGLRRFFKDRWNQLDLAIVLLSVMGITLE---EIEINAALPINPTIIRIMRVLRIARVLK 1562
Query: 190 LFHQKRQLEKLI 201
L + L+
Sbjct: 1563 LLKMATGMRALL 1574
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 42.7 bits (99), Expect = 8e-04
Identities = 38/192 (19%), Positives = 93/192 (48%), Gaps = 12/192 (6%)
Query: 12 GVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDS--KIKKIVHS 69
GV++E + + + + A E +E L RL K + A+ + Y + + ++HS
Sbjct: 1428 GVVVE----NFHKCRQHQEAEEARRREEKRLRRLEK-KRRKAQRLPYYATYCHTRLLIHS 1482
Query: 70 IVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFV 129
+ +S +F F++ L+V + + + L L+Y + F+++ +L++
Sbjct: 1483 MCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY--CNYMFTTVFVLEAVLKLVA 1540
Query: 130 ERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFH 189
+++F D +N LD AI+++ ++ + +I++ +P ++R++R++ + R+
Sbjct: 1541 FGLRRFFKDRWNQLDLAIVLLSVMGITLE---EIEINAALPINPTIIRIMRVLRIARVLK 1597
Query: 190 LFHQKRQLEKLI 201
L + L+
Sbjct: 1598 LLKMATGMRALL 1609
>gi|205277447 dual specificity phosphatase 11 [Homo sapiens]
Length = 377
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/76 (28%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 268 SERAYDPKHFHNRV--VRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLEN--IVAIHCKGG 323
++R Y P+ V ++I H VP + F VN ++ ++ +N ++ +HC G
Sbjct: 143 TQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHG 202
Query: 324 TDRTGTMVCAFLIASE 339
+RTG ++C +LI E
Sbjct: 203 LNRTGYLICRYLIDVE 218
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 41.2 bits (95), Expect = 0.002
Identities = 43/192 (22%), Positives = 88/192 (45%), Gaps = 12/192 (6%)
Query: 12 GVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKF--EVEDAENVASYDSKIKKIVHS 69
GV++E + + + + A E +E L RL + + + A Y S ++ +HS
Sbjct: 1552 GVVVE----NFHKCRQHQEAEEARRREEKRLRRLERRRRKAQRRPYYADY-SPTRRSIHS 1606
Query: 70 IVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFV 129
+ +S LF F++ ++V + + L L+Y + I F + L F
Sbjct: 1607 LCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFG 1666
Query: 130 ERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFH 189
RR +F D +N LD AI+++ L+ + +I++ +P ++R++R++ + R+
Sbjct: 1667 FRR--FFKDRWNQLDLAIVLLSLMGITLE---EIEMSAALPINPTIIRIMRVLRIARVLK 1721
Query: 190 LFHQKRQLEKLI 201
L + L+
Sbjct: 1722 LLKMATGMRALL 1733
>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
sapiens]
Length = 530
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/130 (25%), Positives = 69/130 (53%), Gaps = 12/130 (9%)
Query: 76 FGLFGVFLVLLDVTLILADLIF---TDSKLY-IPLEYRSISLAIALFFLMDVLLRVFVER 131
F F +FLV L+ +++ ++ T++KL+ + L + I L F++++LL+ ++
Sbjct: 110 FKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK-WLSN 168
Query: 132 RQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLF 191
++ +N+ D + ++ LL +VV +L + + L+LLR+ +LR L
Sbjct: 169 FSVFWKSAWNVFDFVVTMLSLLPEVV-------VLVGVTGQSVWLQLLRICRVLRSLKLL 221
Query: 192 HQKRQLEKLI 201
Q RQ++ +I
Sbjct: 222 AQFRQIQIII 231
>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
Length = 528
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/130 (25%), Positives = 69/130 (53%), Gaps = 12/130 (9%)
Query: 76 FGLFGVFLVLLDVTLILADLIF---TDSKLY-IPLEYRSISLAIALFFLMDVLLRVFVER 131
F F +FLV L+ +++ ++ T++KL+ + L + I L F++++LL+ ++
Sbjct: 110 FKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK-WLSN 168
Query: 132 RQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLF 191
++ +N+ D + ++ LL +VV +L + + L+LLR+ +LR L
Sbjct: 169 FSVFWKSAWNVFDFVVTMLSLLPEVV-------VLVGVTGQSVWLQLLRICRVLRSLKLL 221
Query: 192 HQKRQLEKLI 201
Q RQ++ +I
Sbjct: 222 AQFRQIQIII 231
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 40.0 bits (92), Expect = 0.005
Identities = 41/179 (22%), Positives = 84/179 (46%), Gaps = 16/179 (8%)
Query: 12 GVIIELGPNDSPQTSEFKGA----TEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIV 67
GVII+ N + Q +F G TEE + + +L + + + + +K + +V
Sbjct: 1416 GVIID---NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ--KPIPRPANKFQGMV 1470
Query: 68 HSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRV 127
V+ F + + L+ L++ ++ + D Y+ L I+L + F + +L++
Sbjct: 1471 FDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1528
Query: 128 FVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLI 182
V R YF+ +NI D ++++ + L +++ +F L + R + R+LRLI
Sbjct: 1529 -VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLI 1586
Score = 35.4 bits (80), Expect = 0.13
Identities = 39/180 (21%), Positives = 70/180 (38%), Gaps = 15/180 (8%)
Query: 21 DSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFG 80
+ +T + EA E + + +V E ++K +SIV F F
Sbjct: 1104 EQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFI 1163
Query: 81 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 140
VF++LL + + I+ + + I F++++LL+ Q YF++ +
Sbjct: 1164 VFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAW 1223
Query: 141 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHL-----LRLLRLIILLRIFHLFHQKR 195
LD I+ + L + L+ N ++ L LR LR + LR F R
Sbjct: 1224 CWLDFLIVDVSL----------VSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1273
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 40.0 bits (92), Expect = 0.005
Identities = 41/179 (22%), Positives = 84/179 (46%), Gaps = 16/179 (8%)
Query: 12 GVIIELGPNDSPQTSEFKGA----TEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIV 67
GVII+ N + Q +F G TEE + + +L + + + + +K + +V
Sbjct: 1416 GVIID---NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ--KPIPRPANKFQGMV 1470
Query: 68 HSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRV 127
V+ F + + L+ L++ ++ + D Y+ L I+L + F + +L++
Sbjct: 1471 FDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1528
Query: 128 FVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLI 182
V R YF+ +NI D ++++ + L +++ +F L + R + R+LRLI
Sbjct: 1529 -VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLI 1586
Score = 35.4 bits (80), Expect = 0.13
Identities = 39/180 (21%), Positives = 70/180 (38%), Gaps = 15/180 (8%)
Query: 21 DSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFG 80
+ +T + EA E + + +V E ++K +SIV F F
Sbjct: 1104 EQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFI 1163
Query: 81 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 140
VF++LL + + I+ + + I F++++LL+ Q YF++ +
Sbjct: 1164 VFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAW 1223
Query: 141 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHL-----LRLLRLIILLRIFHLFHQKR 195
LD I+ + L + L+ N ++ L LR LR + LR F R
Sbjct: 1224 CWLDFLIVDVSL----------VSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1273
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 40.0 bits (92), Expect = 0.005
Identities = 41/179 (22%), Positives = 84/179 (46%), Gaps = 16/179 (8%)
Query: 12 GVIIELGPNDSPQTSEFKGA----TEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIV 67
GVII+ N + Q +F G TEE + + +L + + + + +K + +V
Sbjct: 1465 GVIID---NFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQ--KPIPRPANKFQGMV 1519
Query: 68 HSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRV 127
V+ F + + L+ L++ ++ + D Y+ L I+L + F + +L++
Sbjct: 1520 FDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIVLFTGEFVLKL 1577
Query: 128 FVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLI 182
V R YF+ +NI D ++++ + L +++ +F L + R + R+LRLI
Sbjct: 1578 -VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLI 1635
Score = 35.4 bits (80), Expect = 0.13
Identities = 39/180 (21%), Positives = 70/180 (38%), Gaps = 15/180 (8%)
Query: 21 DSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFG 80
+ +T + EA E + + +V E ++K +SIV F F
Sbjct: 1153 EQAETEPEEDLKPEACFTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFI 1212
Query: 81 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 140
VF++LL + + I+ + + I F++++LL+ Q YF++ +
Sbjct: 1213 VFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAW 1272
Query: 141 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHL-----LRLLRLIILLRIFHLFHQKR 195
LD I+ + L + L+ N ++ L LR LR + LR F R
Sbjct: 1273 CWLDFLIVDVSL----------VSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMR 1322
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.326 0.141 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,526,563
Number of Sequences: 37866
Number of extensions: 786788
Number of successful extensions: 2647
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2451
Number of HSP's gapped (non-prelim): 234
length of query: 533
length of database: 18,247,518
effective HSP length: 107
effective length of query: 426
effective length of database: 14,195,856
effective search space: 6047434656
effective search space used: 6047434656
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.