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Search of human proteins with 39930577
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39930577 arylsulfatase K [Homo sapiens]
(536 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39930577 arylsulfatase K [Homo sapiens] 1110 0.0
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 99 1e-20
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 97 5e-20
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 97 5e-20
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 97 5e-20
gi|189571643 sulfatase 1 [Homo sapiens] 91 3e-18
gi|189571641 sulfatase 1 [Homo sapiens] 91 3e-18
gi|189571638 sulfatase 1 [Homo sapiens] 91 3e-18
gi|189571636 sulfatase 1 [Homo sapiens] 91 3e-18
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 71 3e-12
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 69 1e-11
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 66 9e-11
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 66 9e-11
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 66 9e-11
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 66 9e-11
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 66 9e-11
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 65 2e-10
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 59 1e-08
gi|31742482 arylsulfatase F precursor [Homo sapiens] 57 3e-08
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 57 4e-08
gi|157266309 arylsulfatase E precursor [Homo sapiens] 54 3e-07
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 53 8e-07
gi|58743319 arylsulfatase family, member H [Homo sapiens] 48 2e-05
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 47 3e-05
gi|109389362 arylsulfatase J [Homo sapiens] 45 2e-04
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 42 0.002
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 40 0.004
gi|45430057 Arylsulfatase G [Homo sapiens] 39 0.012
gi|59797060 arylsulfatase family, member I [Homo sapiens] 36 0.10
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 35 0.13
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 1110 bits (2870), Expect = 0.0
Identities = 536/536 (100%), Positives = 536/536 (100%)
Query: 1 MLLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFI 60
MLLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFI
Sbjct: 1 MLLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFI 60
Query: 61 NFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMERHG 120
NFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMERHG
Sbjct: 61 NFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVMERHG 120
Query: 121 YRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNT 180
YRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNT
Sbjct: 121 YRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNT 180
Query: 181 DKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIK 240
DKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIK
Sbjct: 181 DKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYWLEKVSHDAIK 240
Query: 241 IPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQL 300
IPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQL
Sbjct: 241 IPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQL 300
Query: 301 DLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGIKAGLQVSNVVSLVDI 360
DLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGIKAGLQVSNVVSLVDI
Sbjct: 301 DLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASAHVPLLMMGPGIKAGLQVSNVVSLVDI 360
Query: 361 YPTMLDIAGIPLPQNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGCNVNASTYMLR 420
YPTMLDIAGIPLPQNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGCNVNASTYMLR
Sbjct: 361 YPTMLDIAGIPLPQNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGCNVNASTYMLR 420
Query: 421 TNHWKYIAYSDGASILPQLFDLSSDPDELTNVAVKFPEITYSLDQKLHSIINYPKVSASV 480
TNHWKYIAYSDGASILPQLFDLSSDPDELTNVAVKFPEITYSLDQKLHSIINYPKVSASV
Sbjct: 421 TNHWKYIAYSDGASILPQLFDLSSDPDELTNVAVKFPEITYSLDQKLHSIINYPKVSASV 480
Query: 481 HQYNKEQFIKWKQSIGQNYSNVIANLRWHQDWQKEPRKYENAIDQWLKTHMNPRAV 536
HQYNKEQFIKWKQSIGQNYSNVIANLRWHQDWQKEPRKYENAIDQWLKTHMNPRAV
Sbjct: 481 HQYNKEQFIKWKQSIGQNYSNVIANLRWHQDWQKEPRKYENAIDQWLKTHMNPRAV 536
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 98.6 bits (244), Expect = 1e-20
Identities = 99/424 (23%), Positives = 182/424 (42%), Gaps = 67/424 (15%)
Query: 3 LLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINF 62
LLW+ +V L+ +A G+ Q A NV+L++ D L + G ++V+ P I+
Sbjct: 10 LLWLGLV--LSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCY-GDKLVRSPNIDQ 66
Query: 63 MKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTE--SWNNFKGLDP-NYTTWMDVMERH 119
+ + F NA+ +C PSR + +G T +N++ + N++T + +
Sbjct: 67 LASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKEN 126
Query: 120 GYRTQKFGKLDYT--SGHHSISNRVEAWT-----------RDVAFLLRQEGRPMVNLIRN 166
GY T GK+ + S +H+ + +W+ + +G NL+
Sbjct: 127 GYVTMSVGKVFHPGISSNHT-DDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCP 185
Query: 167 RTKVRVMER---DWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPH-PYPSPSSGENFGSS 222
+ V E D Q+T++A+ L K + PF + +G + PH P+ P +
Sbjct: 186 VDVLDVPEGTLPDKQSTEQAIQLLEKMKTS-ASPFFLAVGYHKPHIPFRYPKEFQK---- 240
Query: 223 TFHTSLYWLEKVS-------HDAIKIPKWSPLSEMHPVDYYSSYTKNCT-GRFTKKEIKN 274
LY LE ++ D + ++P ++ + + + G +
Sbjct: 241 -----LYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRK 295
Query: 275 IRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSMYEASA 334
IR Y+A + D +G ++ AL L L TI+ ++SDHG EH ++ K S ++ +
Sbjct: 296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVAT 355
Query: 335 HVPLLMMGPG-------------------------IKAGLQVSNVVSLVDIYPTMLDIAG 369
HVPL+ PG ++ G Q ++V LV ++PT+ +AG
Sbjct: 356 HVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
Query: 370 IPLP 373
+ +P
Sbjct: 416 LQVP 419
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/382 (25%), Positives = 170/382 (44%), Gaps = 49/382 (12%)
Query: 24 QRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPS 83
QR R PN++LV++D D L GS V M+ G F+NA+ +P+CCPS
Sbjct: 36 QRDRRNIRPNIILVLTDDQDVEL----GSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPS 91
Query: 84 RAAMWSGLFTHLTESW-NNFKGLDPNY------TTWMDVMERHGYRTQKFGKLDYTSGHH 136
R+++ +G + H ++ NN P++ T+ + GYRT FGK Y + ++
Sbjct: 92 RSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK--YLNEYN 149
Query: 137 SISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVR---VMERDWQN---TDKAVNWLRKE 190
+ V ++ LL+ L RN K + +D+ T+ +V++ R
Sbjct: 150 --GSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTS 207
Query: 191 AINYT-EPFVIYLGLNLPH-PYPS-PSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPL 247
Y P ++ + PH P S P F +++ H + + ++P
Sbjct: 208 KKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSY------------NYAPN 255
Query: 248 SEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLL 303
+ H + Y+ K FT +K ++ + + D + I L + L
Sbjct: 256 PDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMS--------VDDSMETIYNMLVETGEL 307
Query: 304 QKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPLLMMGPGIKAGLQVSNVVSLVDIYP 362
T ++Y++DHG + SM YE VP + GP ++AG ++V +D+ P
Sbjct: 308 DNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAP 367
Query: 363 TMLDIAGIPLPQNLSGYSLLPL 384
T+LDIAG+ +P ++ G S+L L
Sbjct: 368 TILDIAGLDIPADMDGKSILKL 389
Score = 30.4 bits (67), Expect = 4.2
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 374 QNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTY--MLRTNHWKYIAYS 430
QN S+ L+ T N+H P W L F C + N +TY M N +
Sbjct: 715 QNNDTCSMPGLTCFTHDNQHW--QTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFC 772
Query: 431 DGASILPQLFDLSSDPDELTN 451
+ A+ + FDL++DP +L N
Sbjct: 773 EFATGFLEYFDLNTDPYQLMN 793
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/382 (25%), Positives = 170/382 (44%), Gaps = 49/382 (12%)
Query: 24 QRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPS 83
QR R PN++LV++D D L GS V M+ G F+NA+ +P+CCPS
Sbjct: 36 QRDRRNIRPNIILVLTDDQDVEL----GSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPS 91
Query: 84 RAAMWSGLFTHLTESW-NNFKGLDPNY------TTWMDVMERHGYRTQKFGKLDYTSGHH 136
R+++ +G + H ++ NN P++ T+ + GYRT FGK Y + ++
Sbjct: 92 RSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK--YLNEYN 149
Query: 137 SISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVR---VMERDWQN---TDKAVNWLRKE 190
+ V ++ LL+ L RN K + +D+ T+ +V++ R
Sbjct: 150 --GSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTS 207
Query: 191 AINYT-EPFVIYLGLNLPH-PYPS-PSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPL 247
Y P ++ + PH P S P F +++ H + + ++P
Sbjct: 208 KKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSY------------NYAPN 255
Query: 248 SEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLL 303
+ H + Y+ K FT +K ++ + + D + I L + L
Sbjct: 256 PDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMS--------VDDSMETIYNMLVETGEL 307
Query: 304 QKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPLLMMGPGIKAGLQVSNVVSLVDIYP 362
T ++Y++DHG + SM YE VP + GP ++AG ++V +D+ P
Sbjct: 308 DNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAP 367
Query: 363 TMLDIAGIPLPQNLSGYSLLPL 384
T+LDIAG+ +P ++ G S+L L
Sbjct: 368 TILDIAGLDIPADMDGKSILKL 389
Score = 30.4 bits (67), Expect = 4.2
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 374 QNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTY--MLRTNHWKYIAYS 430
QN S+ L+ T N+H P W L F C + N +TY M N +
Sbjct: 715 QNNDTCSMPGLTCFTHDNQHW--QTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFC 772
Query: 431 DGASILPQLFDLSSDPDELTN 451
+ A+ + FDL++DP +L N
Sbjct: 773 EFATGFLEYFDLNTDPYQLMN 793
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 96.7 bits (239), Expect = 5e-20
Identities = 98/382 (25%), Positives = 170/382 (44%), Gaps = 49/382 (12%)
Query: 24 QRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPS 83
QR R PN++LV++D D L GS V M+ G F+NA+ +P+CCPS
Sbjct: 36 QRDRRNIRPNIILVLTDDQDVEL----GSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPS 91
Query: 84 RAAMWSGLFTHLTESW-NNFKGLDPNY------TTWMDVMERHGYRTQKFGKLDYTSGHH 136
R+++ +G + H ++ NN P++ T+ + GYRT FGK Y + ++
Sbjct: 92 RSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK--YLNEYN 149
Query: 137 SISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVR---VMERDWQN---TDKAVNWLRKE 190
+ V ++ LL+ L RN K + +D+ T+ +V++ R
Sbjct: 150 --GSYVPPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTS 207
Query: 191 AINYT-EPFVIYLGLNLPH-PYPS-PSSGENFGSSTFHTSLYWLEKVSHDAIKIPKWSPL 247
Y P ++ + PH P S P F +++ H + + ++P
Sbjct: 208 KKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSY------------NYAPN 255
Query: 248 SEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLL 303
+ H + Y+ K FT +K ++ + + D + I L + L
Sbjct: 256 PDKHWIMRYTGPMKPIHMEFTNMLQRKRLQTLMS--------VDDSMETIYNMLVETGEL 307
Query: 304 QKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPLLMMGPGIKAGLQVSNVVSLVDIYP 362
T ++Y++DHG + SM YE VP + GP ++AG ++V +D+ P
Sbjct: 308 DNTYIVYTADHGYHIGQFGLVKGKSMPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAP 367
Query: 363 TMLDIAGIPLPQNLSGYSLLPL 384
T+LDIAG+ +P ++ G S+L L
Sbjct: 368 TILDIAGLDIPADMDGKSILKL 389
Score = 30.4 bits (67), Expect = 4.2
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 374 QNLSGYSLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTY--MLRTNHWKYIAYS 430
QN S+ L+ T N+H P W L F C + N +TY M N +
Sbjct: 715 QNNDTCSMPGLTCFTHDNQHW--QTAPFWTLGPFCACTSANNNTYWCMRTINETHNFLFC 772
Query: 431 DGASILPQLFDLSSDPDELTN 451
+ A+ + FDL++DP +L N
Sbjct: 773 EFATGFLEYFDLNTDPYQLMN 793
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 90.9 bits (224), Expect = 3e-18
Identities = 98/406 (24%), Positives = 180/406 (44%), Gaps = 49/406 (12%)
Query: 1 MLLLWVSVVAALALAVLAP---GAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKL 57
+ +L ++ +L V +P G +Q R+ + PN++LV++D D L GS V
Sbjct: 10 LAVLGTELLGSLCSTVRSPRFRGRIQQERKNIR-PNIILVLTDDQDVEL----GSLQVMN 64
Query: 58 PFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESW-NNFKGLDPNY------T 110
M+ G +F+NA+ +P+CCPSR++M +G + H + NN P++
Sbjct: 65 KTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPR 124
Query: 111 TWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKV 170
T+ + GYRT FGK Y + ++ + + R+ L++ + RN K
Sbjct: 125 TFAVYLNNTGYRTAFFGK--YLNEYN--GSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 171 R---VMERDWQN---TDKAVNWLRKEAINYT-EPFVIYLGLNLPHPYPSPSSGENFGSST 223
+ +D+ T++++N+ + Y P ++ + PH P S+ +
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHG-PEDSAPQ------ 233
Query: 224 FHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFY 279
+ LY S ++P + H + Y+ FT +K ++ + +
Sbjct: 234 -FSKLY--PNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS-- 288
Query: 280 YAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPL 338
D + + L + L+ T +IY++DHG + SM Y+ VP
Sbjct: 289 ------VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPF 342
Query: 339 LMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPL 384
+ GP ++ G V +V +D+ PT+LDIAG+ P ++ G S+L L
Sbjct: 343 FIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKL 388
Score = 29.6 bits (65), Expect = 7.2
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 5/75 (6%)
Query: 380 SLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTYM-LRT-NHWKYIAYSDGASIL 436
SL L+ T N H P W L F C + N +TY LRT N + + A+
Sbjct: 740 SLPGLTCFTHDNNHW--QTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGF 797
Query: 437 PQLFDLSSDPDELTN 451
+ FD+++DP +LTN
Sbjct: 798 LEYFDMNTDPYQLTN 812
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 90.9 bits (224), Expect = 3e-18
Identities = 98/406 (24%), Positives = 180/406 (44%), Gaps = 49/406 (12%)
Query: 1 MLLLWVSVVAALALAVLAP---GAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKL 57
+ +L ++ +L V +P G +Q R+ + PN++LV++D D L GS V
Sbjct: 10 LAVLGTELLGSLCSTVRSPRFRGRIQQERKNIR-PNIILVLTDDQDVEL----GSLQVMN 64
Query: 58 PFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESW-NNFKGLDPNY------T 110
M+ G +F+NA+ +P+CCPSR++M +G + H + NN P++
Sbjct: 65 KTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPR 124
Query: 111 TWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKV 170
T+ + GYRT FGK Y + ++ + + R+ L++ + RN K
Sbjct: 125 TFAVYLNNTGYRTAFFGK--YLNEYN--GSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 171 R---VMERDWQN---TDKAVNWLRKEAINYT-EPFVIYLGLNLPHPYPSPSSGENFGSST 223
+ +D+ T++++N+ + Y P ++ + PH P S+ +
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHG-PEDSAPQ------ 233
Query: 224 FHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFY 279
+ LY S ++P + H + Y+ FT +K ++ + +
Sbjct: 234 -FSKLY--PNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS-- 288
Query: 280 YAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPL 338
D + + L + L+ T +IY++DHG + SM Y+ VP
Sbjct: 289 ------VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPF 342
Query: 339 LMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPL 384
+ GP ++ G V +V +D+ PT+LDIAG+ P ++ G S+L L
Sbjct: 343 FIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKL 388
Score = 29.6 bits (65), Expect = 7.2
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 5/75 (6%)
Query: 380 SLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTYM-LRT-NHWKYIAYSDGASIL 436
SL L+ T N H P W L F C + N +TY LRT N + + A+
Sbjct: 740 SLPGLTCFTHDNNHW--QTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGF 797
Query: 437 PQLFDLSSDPDELTN 451
+ FD+++DP +LTN
Sbjct: 798 LEYFDMNTDPYQLTN 812
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 90.9 bits (224), Expect = 3e-18
Identities = 98/406 (24%), Positives = 180/406 (44%), Gaps = 49/406 (12%)
Query: 1 MLLLWVSVVAALALAVLAP---GAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKL 57
+ +L ++ +L V +P G +Q R+ + PN++LV++D D L GS V
Sbjct: 10 LAVLGTELLGSLCSTVRSPRFRGRIQQERKNIR-PNIILVLTDDQDVEL----GSLQVMN 64
Query: 58 PFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESW-NNFKGLDPNY------T 110
M+ G +F+NA+ +P+CCPSR++M +G + H + NN P++
Sbjct: 65 KTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPR 124
Query: 111 TWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKV 170
T+ + GYRT FGK Y + ++ + + R+ L++ + RN K
Sbjct: 125 TFAVYLNNTGYRTAFFGK--YLNEYN--GSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 171 R---VMERDWQN---TDKAVNWLRKEAINYT-EPFVIYLGLNLPHPYPSPSSGENFGSST 223
+ +D+ T++++N+ + Y P ++ + PH P S+ +
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHG-PEDSAPQ------ 233
Query: 224 FHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFY 279
+ LY S ++P + H + Y+ FT +K ++ + +
Sbjct: 234 -FSKLY--PNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS-- 288
Query: 280 YAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPL 338
D + + L + L+ T +IY++DHG + SM Y+ VP
Sbjct: 289 ------VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPF 342
Query: 339 LMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPL 384
+ GP ++ G V +V +D+ PT+LDIAG+ P ++ G S+L L
Sbjct: 343 FIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKL 388
Score = 29.6 bits (65), Expect = 7.2
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 5/75 (6%)
Query: 380 SLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTYM-LRT-NHWKYIAYSDGASIL 436
SL L+ T N H P W L F C + N +TY LRT N + + A+
Sbjct: 740 SLPGLTCFTHDNNHW--QTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGF 797
Query: 437 PQLFDLSSDPDELTN 451
+ FD+++DP +LTN
Sbjct: 798 LEYFDMNTDPYQLTN 812
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 90.9 bits (224), Expect = 3e-18
Identities = 98/406 (24%), Positives = 180/406 (44%), Gaps = 49/406 (12%)
Query: 1 MLLLWVSVVAALALAVLAP---GAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKL 57
+ +L ++ +L V +P G +Q R+ + PN++LV++D D L GS V
Sbjct: 10 LAVLGTELLGSLCSTVRSPRFRGRIQQERKNIR-PNIILVLTDDQDVEL----GSLQVMN 64
Query: 58 PFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTESW-NNFKGLDPNY------T 110
M+ G +F+NA+ +P+CCPSR++M +G + H + NN P++
Sbjct: 65 KTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAMHEPR 124
Query: 111 TWMDVMERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNRTKV 170
T+ + GYRT FGK Y + ++ + + R+ L++ + RN K
Sbjct: 125 TFAVYLNNTGYRTAFFGK--YLNEYN--GSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 171 R---VMERDWQN---TDKAVNWLRKEAINYT-EPFVIYLGLNLPHPYPSPSSGENFGSST 223
+ +D+ T++++N+ + Y P ++ + PH P S+ +
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMYPHRPVMMVISHAAPHG-PEDSAPQ------ 233
Query: 224 FHTSLYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFT----KKEIKNIRAFY 279
+ LY S ++P + H + Y+ FT +K ++ + +
Sbjct: 234 -FSKLY--PNASQHITPSYNYAPNMDKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMS-- 288
Query: 280 YAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFYKMSM-YEASAHVPL 338
D + + L + L+ T +IY++DHG + SM Y+ VP
Sbjct: 289 ------VDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPF 342
Query: 339 LMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQNLSGYSLLPL 384
+ GP ++ G V +V +D+ PT+LDIAG+ P ++ G S+L L
Sbjct: 343 FIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLDTPPDVDGKSVLKL 388
Score = 29.6 bits (65), Expect = 7.2
Identities = 26/75 (34%), Positives = 37/75 (49%), Gaps = 5/75 (6%)
Query: 380 SLLPLSSETFKNEHKVKNLHPPWILSEFHGC-NVNASTYM-LRT-NHWKYIAYSDGASIL 436
SL L+ T N H P W L F C + N +TY LRT N + + A+
Sbjct: 740 SLPGLTCFTHDNNHW--QTAPFWNLGSFCACTSSNNNTYWCLRTVNETHNFLFCEFATGF 797
Query: 437 PQLFDLSSDPDELTN 451
+ FD+++DP +LTN
Sbjct: 798 LEYFDMNTDPYQLTN 812
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 70.9 bits (172), Expect = 3e-12
Identities = 80/343 (23%), Positives = 147/343 (42%), Gaps = 42/343 (12%)
Query: 3 LLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINF 62
LLW+ +V L+ +A G+ Q A NV+L++ D L + G ++V+ P I+
Sbjct: 10 LLWLGLV--LSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCY-GDKLVRSPNIDQ 66
Query: 63 MKTRGTSFLNAYTNSPICCPSRAAMWSGL---FTHLTESWNNFKGLDPNYTTWMDVMERH 119
+ + F NA+ +C PSR + +G T L + + ++ N++T + +
Sbjct: 67 LASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFSTIPQYFKEN 126
Query: 120 GYRTQKFGKLDY--TSGHHSISNRVEAWT-----------RDVAFLLRQEGRPMVNLIRN 166
GY T GK+ + S +H+ + +W+ + +G NL+
Sbjct: 127 GYVTMSVGKVFHPGISSNHT-DDSPYSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCP 185
Query: 167 RTKVRVME---RDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPH-PYPSPSSGENFGSS 222
+ V E D Q+T++A+ L K + PF + +G + PH P+ P +
Sbjct: 186 VDVLDVPEGTLPDKQSTEQAIQLLEKMKTS-ASPFFLAVGYHKPHIPFRYPKEFQ----- 239
Query: 223 TFHTSLYWLEKVS-------HDAIKIPKWSPLSEMHPVDYYSSYTKNCT-GRFTKKEIKN 274
LY LE ++ D + ++P ++ + + + G +
Sbjct: 240 ----KLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRK 295
Query: 275 IRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGEL 317
IR Y+A + D +G ++ AL L L TI+ ++SDHG L
Sbjct: 296 IRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGFL 338
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 68.6 bits (166), Expect = 1e-11
Identities = 96/380 (25%), Positives = 155/380 (40%), Gaps = 74/380 (19%)
Query: 29 AKAPNVVLVVSDSFDGRLTFHPGS---QVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
A+ N +L+++D DG F G+ + P ++ + R F NA+T+ C PSRA
Sbjct: 20 ARPRNALLLLAD--DGG--FESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRA 75
Query: 86 AMWSGLFTH------LTESWNNFKGLDPNYTTWMDVMERHGYRTQKFGKLDYTSGHHSIS 139
++ +GL H L + ++F D + + ++ + G RT GK H
Sbjct: 76 SLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-LLSQAGVRTGIIGK------KHVGP 128
Query: 140 NRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNTDKAVNWLRKEAINYTEPFV 199
V + F +E ++ + RN T+++++ R + T PF
Sbjct: 129 ETVYPFD----FAYTEENGSVLQVGRNITRIKLLVRKFLQTQD------------DRPFF 172
Query: 200 IYLGLNLPH--PYPSPSSG---ENFGSSTFHTSLYWLEKVSHDAIKIPKWSPLSEMHPVD 254
+Y+ + PH + P G E FG+ +IP W+P P+D
Sbjct: 173 LYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMG------------RIPDWTP-QAYDPLD 219
Query: 255 YYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDH 314
Y T + A Y D +G ++ L +L T+VI++SD+
Sbjct: 220 VLVPYFVPNT-----PAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDN 274
Query: 315 GELAMEHRQFYKMSMYEASAHVPLLMMGP-GIKAGLQVSNV-VSLVDIYPTMLDIAGIPL 372
G R ++Y PLL+ P K QVS VSL+D+ PT+LD IP
Sbjct: 275 GIPFPSGR----TNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPY 330
Query: 373 PQ---------NLSGYSLLP 383
P +L+G SLLP
Sbjct: 331 PSYAIFGSKTIHLTGRSLLP 350
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372
Query: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
+P + E G + +RT +K ++ G A
Sbjct: 373 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425
Query: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
P L+DLS DP E L VA PE+ +L Q
Sbjct: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Score = 35.0 bits (79), Expect = 0.17
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 12/109 (11%)
Query: 29 AKAPNVVLVVSDSF---DGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
A+ PN+VL+ +D D HP S P ++ + G F + Y +C PSRA
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTT---PNLDQLAAGGLRFTDFYVPVSLCTPSRA 74
Query: 86 AMWSGLFTHLTESW------NNFKGLDPNYTTWMDVMERHGYRTQKFGK 128
A+ +G + ++ GL T +V+ GY T GK
Sbjct: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372
Query: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
+P + E G + +RT +K ++ G A
Sbjct: 373 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425
Query: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
P L+DLS DP E L VA PE+ +L Q
Sbjct: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Score = 35.0 bits (79), Expect = 0.17
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 12/109 (11%)
Query: 29 AKAPNVVLVVSDSF---DGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
A+ PN+VL+ +D D HP S P ++ + G F + Y +C PSRA
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTT---PNLDQLAAGGLRFTDFYVPVSLCTPSRA 74
Query: 86 AMWSGLFTHLTESW------NNFKGLDPNYTTWMDVMERHGYRTQKFGK 128
A+ +G + ++ GL T +V+ GY T GK
Sbjct: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 169 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 228
Query: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 229 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 288
Query: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
+P + E G + +RT +K ++ G A
Sbjct: 289 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 341
Query: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
P L+DLS DP E L VA PE+ +L Q
Sbjct: 342 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 374
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372
Query: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
+P + E G + +RT +K ++ G A
Sbjct: 373 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425
Query: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
P L+DLS DP E L VA PE+ +L Q
Sbjct: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Score = 35.0 bits (79), Expect = 0.17
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 12/109 (11%)
Query: 29 AKAPNVVLVVSDSF---DGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
A+ PN+VL+ +D D HP S P ++ + G F + Y +C PSRA
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTT---PNLDQLAAGGLRFTDFYVPVSLCTPSRA 74
Query: 86 AMWSGLFTHLTESW------NNFKGLDPNYTTWMDVMERHGYRTQKFGK 128
A+ +G + ++ GL T +V+ GY T GK
Sbjct: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 65.9 bits (159), Expect = 9e-11
Identities = 61/213 (28%), Positives = 92/213 (43%), Gaps = 39/213 (18%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHR--------QFYKMSMYEASAHV 336
E DA +G ++ A+ L LL++T+VI+++D+G M + K + YE
Sbjct: 253 ELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVRE 312
Query: 337 PLLMMGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPLSSETFKNEHKV 395
P L PG A + S +D+ PT+ +AG PLP L G+ L PL T K+ +
Sbjct: 313 PALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQS 372
Query: 396 KNLHPPWILSEFHGCNVNASTYMLRTNHWKYIAYSDG-------------------ASIL 436
+P + E G + +RT +K ++ G A
Sbjct: 373 LFFYPSY-PDEVRG------VFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEP 425
Query: 437 PQLFDLSSDPDE----LTNVAVKFPEITYSLDQ 465
P L+DLS DP E L VA PE+ +L Q
Sbjct: 426 PLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Score = 35.0 bits (79), Expect = 0.17
Identities = 30/109 (27%), Positives = 46/109 (42%), Gaps = 12/109 (11%)
Query: 29 AKAPNVVLVVSDSF---DGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
A+ PN+VL+ +D D HP S P ++ + G F + Y +C PSRA
Sbjct: 18 ARPPNIVLIFADDLGYGDLGCYGHPSSTT---PNLDQLAAGGLRFTDFYVPVSLCTPSRA 74
Query: 86 AMWSGLFTHLTESW------NNFKGLDPNYTTWMDVMERHGYRTQKFGK 128
A+ +G + ++ GL T +V+ GY T GK
Sbjct: 75 ALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/214 (27%), Positives = 106/214 (49%), Gaps = 39/214 (18%)
Query: 287 DAMLGEIILALHQLDLLQKTIVIYSSDHG------ELAMEHRQFYKMSMYEASAHVPLLM 340
D ++ +++ L L T + Y+SD+G L ++ RQ +YE VPLL+
Sbjct: 300 DDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQ-----LYEFDIKVPLLV 354
Query: 341 MGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPL----SSETFKNEHKV 395
GPGIK +V+ +D+ PT+LDIAG L + + G SLLP+ S+ T++++ V
Sbjct: 355 RGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLV 414
Query: 396 ------KNLHPPWILSEFHGCN-----------VNASTYMLRTN----HWKYIAYSDGAS 434
+N+ P S G + N + +RT + +Y + D
Sbjct: 415 EYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDD-QE 473
Query: 435 ILPQLFDLSSDPDELTNVAVKF-PEITYSLDQKL 467
+ ++++L++DPD++TN+A PE+ ++ +L
Sbjct: 474 VFVEVYNLTADPDQITNIAKTIDPELLGKMNYRL 507
Score = 42.7 bits (99), Expect = 8e-04
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 10/104 (9%)
Query: 14 LAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNA 73
L V AG +R PNVVL+++D D L G + G +F +A
Sbjct: 35 LGVFGVAAGTRR------PNVVLLLTDDQDEVL----GGMTPLKKTKALIGEMGMTFSSA 84
Query: 74 YTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVME 117
Y S +CCPSRA++ +G + H NN + + +W + E
Sbjct: 85 YVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQE 128
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 58.9 bits (141), Expect = 1e-08
Identities = 97/415 (23%), Positives = 161/415 (38%), Gaps = 85/415 (20%)
Query: 7 SVVAALA---LAVLAPGAGEQRRRAAKAPNVVLVVSDSFD-GRLTFHPGSQVVKLPFINF 62
+VVAA L ++ AG A + PN++L++ D G L + G + P ++
Sbjct: 3 AVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVY-GEPSRETPNLDR 61
Query: 63 MKTRGTSFLNAYTNSPICCPSRAAMWSG-------LFTHLTESWNNFK------GLDPNY 109
M G F N Y+ +P+C PSRAA+ +G +T + N + G+ +
Sbjct: 62 MAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSE 121
Query: 110 TTWMDVMERHGYRTQKFGK--LDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNR 167
+++++ GY ++ GK L + H + + + W G P +
Sbjct: 122 QLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWF----------GSPNCHFGPYD 171
Query: 168 TKVRV---MERDWQNTDKAVNWLRKEAINYTEPFVIYLGL---NLPHPYPSPSSGENFGS 221
K R + RDW+ + Y E F I L NL Y +
Sbjct: 172 NKARPNIPVYRDWEMVGR-----------YYEEFPINLKTGEANLTQIYLQEALDFIKRQ 220
Query: 222 STFHTS-LYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYY 280
+ H LYW +H + Y+S T + R Y
Sbjct: 221 ARHHPFFLYWAVDATHAPV----------------YASKPFLGTSQ---------RGRYG 255
Query: 281 AMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG-------ELAMEHRQFY--KMSMYE 331
E D +G+I+ L L + T V ++SD+G E + F K + +E
Sbjct: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315
Query: 332 ASAHVPLLMMGPGIKAGLQVSNVV-SLVDIYPTMLDIAGIPLPQN--LSGYSLLP 383
P L PG QVS+ + S++D++ T L +AG+ P + + G +LLP
Sbjct: 316 GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLP 370
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 57.4 bits (137), Expect = 3e-08
Identities = 60/209 (28%), Positives = 92/209 (44%), Gaps = 51/209 (24%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQ------FYK----MSMYE 331
E D+M+G+I+ A+ L T+V ++SDHG E H Q YK M +E
Sbjct: 317 EMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWE 376
Query: 332 ASAHVPLLMMGPG-IKAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--LSGYSLLPLSSET 388
VP ++ PG + AG + SL+DI PT+ ++G LPQ+ + G L+PL
Sbjct: 377 GGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGN 436
Query: 389 FK-NEHKVKNLHPPWILSEFHGCNVNASTYMLRTNH---WK--YIA------YSDGASIL 436
+ +EH+ L + G ++A ++ + + WK Y+ S G +
Sbjct: 437 VRHSEHE--------FLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVT 488
Query: 437 ---------------PQLFDLSSDPDELT 450
P LFDLS DP E T
Sbjct: 489 SLCRCFGEQVTYHNPPLLFDLSRDPSEST 517
Score = 37.7 bits (86), Expect = 0.027
Identities = 35/138 (25%), Positives = 62/138 (44%), Gaps = 19/138 (13%)
Query: 3 LLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFD-GRLTFHPGSQVVKLPFIN 61
L+++S+V AL A + + PN+VL++ D G L + G+ ++ P I+
Sbjct: 7 LVFMSLVCALLNTCQAHRVHDDK------PNIVLIMVDDLGIGDLGCY-GNDTMRTPHID 59
Query: 62 FMKTRGTSFLNAYTNSPICCPSRAAMWSGLF---THLTESWNNF--------KGLDPNYT 110
+ G + + +C PSR+A +G + + + S N GL N T
Sbjct: 60 RLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET 119
Query: 111 TWMDVMERHGYRTQKFGK 128
T ++++ GY T GK
Sbjct: 120 TLAALLKKQGYSTGLIGK 137
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 57.0 bits (136), Expect = 4e-08
Identities = 61/237 (25%), Positives = 103/237 (43%), Gaps = 56/237 (23%)
Query: 258 SYTKNCTGRFTKKEI--KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG 315
SY T F+ K+ K+ Y E D +G+I+ L +L L T++ ++SD G
Sbjct: 285 SYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQG 344
Query: 316 ----------ELAMEHRQFYK---MSMYEASAHVPLLMMGPG-IKAGLQVSNVVSLVDIY 361
E+ YK + +E VP ++ P I+AG ++ S +DI+
Sbjct: 345 AHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIF 404
Query: 362 PTMLDIAGIPLPQN--LSGYSLLP-LSSETFKNEHKVKNLHPPWILSEFHGCN--VNAST 416
PT+ +AG PLP++ + G L+P L ++ +++H+ FH CN +NA
Sbjct: 405 PTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFL----------FHYCNAYLNAVR 454
Query: 417 Y--MLRTNHWK-------------------YIAYSDGASIL----PQLFDLSSDPDE 448
+ T+ WK ++ + G+ + P LFD+S DP E
Sbjct: 455 WHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRE 511
Score = 45.8 bits (107), Expect = 1e-04
Identities = 33/126 (26%), Positives = 55/126 (43%), Gaps = 11/126 (8%)
Query: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
E AA PN++LV++D G++ ++ P I+ + + G SP+C P
Sbjct: 18 EAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTP 77
Query: 83 SRAAMWSGLFTHLT--ESWN---------NFKGLDPNYTTWMDVMERHGYRTQKFGKLDY 131
SRAA +G + + SW+ + GL + T+ +++ GY T GK
Sbjct: 78 SRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHL 137
Query: 132 TSGHHS 137
HS
Sbjct: 138 GMSCHS 143
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 54.3 bits (129), Expect = 3e-07
Identities = 40/128 (31%), Positives = 64/128 (50%), Gaps = 16/128 (12%)
Query: 273 KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQF----- 324
K++ Y E D M+G I+ L L T++ ++SDHG E + + Q+
Sbjct: 313 KSLHGLYGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNG 372
Query: 325 -YK----MSMYEASAHVPLLMMGPGI-KAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--L 376
YK M +E VP + PG+ AG + SL+D++PT++ +AG +PQ+ +
Sbjct: 373 IYKGGKGMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVI 432
Query: 377 SGYSLLPL 384
G LLPL
Sbjct: 433 DGQDLLPL 440
Score = 43.1 bits (100), Expect = 6e-04
Identities = 34/135 (25%), Positives = 59/135 (43%), Gaps = 14/135 (10%)
Query: 5 WVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMK 64
W+ + A+ L+ LAP A +A PN++L+++D G+ ++ P I+ +
Sbjct: 14 WLPAMLAVLLS-LAPSASSDI--SASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLA 70
Query: 65 TRGTSFLNAYTNSPICCPSRAAMWSGLFT----------HLTESWNNFKG-LDPNYTTWM 113
G + + +C PSRAA +G + + W G L N TT+
Sbjct: 71 EDGVKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFA 130
Query: 114 DVMERHGYRTQKFGK 128
+++ GY T GK
Sbjct: 131 KILKEKGYATGLIGK 145
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 52.8 bits (125), Expect = 8e-07
Identities = 38/128 (29%), Positives = 62/128 (48%), Gaps = 16/128 (12%)
Query: 273 KNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQF----- 324
K+ Y E D ++G+++ A+ L T ++SDHG E H Q
Sbjct: 316 KSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNG 375
Query: 325 -YK----MSMYEASAHVPLLMMGPGI-KAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--L 376
YK M +E VP + PG+ AG + SL+D++PT++ + G +PQ+ +
Sbjct: 376 IYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVI 435
Query: 377 SGYSLLPL 384
G+SL+PL
Sbjct: 436 DGHSLVPL 443
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
E + A PN++L+++D G+ ++ P I+ + G +P+C P
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 83 SRAAMWSGLFT----------HLTESWN-NFKGLDPNYTTWMDVMERHGYRTQKFGK 128
SRAA +G + + WN GL N TT+ ++++HGY T GK
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGK 148
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/207 (28%), Positives = 86/207 (41%), Gaps = 53/207 (25%)
Query: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHG------ELAME---HRQFYK----MSMYE 331
E D M+G+I+ AL Q L T+V ++SD+G + A++ YK M +E
Sbjct: 295 EMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWE 354
Query: 332 ASAHVPLLMMGPGI-KAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--LSGYSLLPL-SSE 387
VP + P + +AG ++ SL+DIYPT+ I G L Q+ + G +L+PL
Sbjct: 355 GGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGR 414
Query: 388 TFKNEHKVKNLHPPWILSEFHGCNVNASTYMLRTNH----WK--YIA---YSDGASIL-- 436
++H+ FH C V T WK Y+ Y +G
Sbjct: 415 ASHSDHEFL----------FHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGTGACYG 464
Query: 437 ---------------PQLFDLSSDPDE 448
P LFD+S DP E
Sbjct: 465 SGICSCSGDVTYHDPPLLFDISRDPSE 491
Score = 42.0 bits (97), Expect = 0.001
Identities = 31/110 (28%), Positives = 53/110 (48%), Gaps = 14/110 (12%)
Query: 32 PNVVLVVSDSFD-GRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSG 90
PN+VL+++D G L + G+ V P I+ + + G + +C PSRAA +G
Sbjct: 7 PNIVLLMADDLGVGDLCCY-GNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTG 65
Query: 91 LF---THLTESWNNFK---------GLDPNYTTWMDVMERHGYRTQKFGK 128
+ + + ++N + GL N TT+ +++ GYRT GK
Sbjct: 66 RYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGK 115
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 47.4 bits (111), Expect = 3e-05
Identities = 31/117 (26%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
E + A PN++L+++D G+ ++ P I+ + G +P+C P
Sbjct: 32 EPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTP 91
Query: 83 SRAAMWSGLFT----------HLTESWN-NFKGLDPNYTTWMDVMERHGYRTQKFGK 128
SRAA +G + + WN GL N TT+ ++++HGY T GK
Sbjct: 92 SRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQQHGYATGLIGK 148
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 45.1 bits (105), Expect = 2e-04
Identities = 55/241 (22%), Positives = 99/241 (41%), Gaps = 43/241 (17%)
Query: 270 KEIKNI-RAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY--- 325
+ I NI R Y AM + D + + LAL +I+IYSSD+G +
Sbjct: 283 RSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLR 342
Query: 326 --KMSMYEASAHVPLLMMGPGIK-AGLQVSNVVSLVDIYPTMLDIAGIPLPQN--LSGYS 380
K + +E + P +K G +V + D YPT++ +A + ++ L GY
Sbjct: 343 GSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYD 402
Query: 381 LLPLSSETFKNEHK--VKNLHPPWILSE------FHGCNVNASTYMLRTNHWKYIAYSDG 432
+ SE ++ + N+ P + ++ +G A +R HWK + + G
Sbjct: 403 IWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPG 462
Query: 433 AS--ILPQ------------------------LFDLSSDPDELTNVAVKFPEITYSLDQK 466
S + PQ LF++++DP E +++ ++P I L ++
Sbjct: 463 YSDWVPPQSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDLSNRYPGIVKKLLRR 522
Query: 467 L 467
L
Sbjct: 523 L 523
Score = 33.1 bits (74), Expect = 0.66
Identities = 27/112 (24%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 23 EQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCP 82
E + P+++ +++D R + GS++ K P ++ + G N Y PIC P
Sbjct: 67 EPSTTSTSQPHLIFILADDQGFRDVGYHGSEI-KTPTLDKLAAEGVKLENYYVQ-PICTP 124
Query: 83 SRAAMWSGLF-THLTESWNNFKGLDPN-----YTTWMDVMERHGYRTQKFGK 128
SR+ +G + H + + PN T ++ GY T GK
Sbjct: 125 SRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGK 176
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 41.6 bits (96), Expect = 0.002
Identities = 107/526 (20%), Positives = 191/526 (36%), Gaps = 101/526 (19%)
Query: 2 LLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFIN 61
LLL V + L L + PG+G A++ P++V +++D GS++ + P ++
Sbjct: 18 LLLPVVLPLLLLLLLAPPGSGAG---ASRPPHLVFLLADDLGWNDVGFHGSRI-RTPHLD 73
Query: 62 FMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTE-----SWNNFKGLDP-NYTTWMDV 115
+ G N YT P+C PSR+ + +G + T W P + +
Sbjct: 74 ALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQL 132
Query: 116 MERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQE---GRPMVNLI--RNRTKV 170
++ GY T GK + +LL E LI N T+
Sbjct: 133 LKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRC 192
Query: 171 RVMERDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYW 230
+ RD + + A + + N I L N HP P LY
Sbjct: 193 ALDFRDGE--EVATGYKNMYSTNIFTKRAIALITN--HPPEKP------------LFLYL 236
Query: 231 LEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAML 290
+ H+ +++P+ + P D+ KN R Y M + D +
Sbjct: 237 ALQSVHEPLQVPE----EYLKPYDFIQD--KN-------------RHHYAGMVSLMDEAV 277
Query: 291 GEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY-----KMSMYEASAHVPLLMMGPGI 345
G + AL L T+ I+S+D+G + + K S++E + P +
Sbjct: 278 GNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
Query: 346 K-AGLQVSNVVSLVDIYPTMLDIA--GIPLPQNLSGYSLLPLSSETFKNE--HKVKNLHP 400
K G++ ++ + D PT++ +A + L G+ + SE + + N+ P
Sbjct: 338 KQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDP 397
Query: 401 PWI------------------LSEFHGCNVNASTYMLRTNHWKYIAYSDG---------- 432
++ L E+ N + +R +WK + G
Sbjct: 398 NFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHA-AIRHGNWKLLTGYPGCGYWFPPPSQ 456
Query: 433 --ASILPQ---------LFDLSSDPDELTNVAVKFPEITYSLDQKL 467
S +P LFD+ DP+E +++ ++P I L +L
Sbjct: 457 YNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRL 502
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 40.4 bits (93), Expect = 0.004
Identities = 82/384 (21%), Positives = 144/384 (37%), Gaps = 57/384 (14%)
Query: 2 LLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFIN 61
LLL V + L L + PG+G A++ P++V +++D GS++ + P ++
Sbjct: 18 LLLPVVLPLLLLLLLAPPGSGAG---ASRPPHLVFLLADDLGWNDVGFHGSRI-RTPHLD 73
Query: 62 FMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTE-----SWNNFKGLDP-NYTTWMDV 115
+ G N YT P+C PSR+ + +G + T W P + +
Sbjct: 74 ALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQL 132
Query: 116 MERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQE---GRPMVNLI--RNRTKV 170
++ GY T GK + +LL E LI N T+
Sbjct: 133 LKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRC 192
Query: 171 RVMERDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYW 230
+ RD + + A + + N I L N HP P LY
Sbjct: 193 ALDFRDGE--EVATGYKNMYSTNIFTKRAIALITN--HPPEKP------------LFLYL 236
Query: 231 LEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAML 290
+ H+ +++P+ + P D+ KN R Y M + D +
Sbjct: 237 ALQSVHEPLQVPE----EYLKPYDFIQD--KN-------------RHHYAGMVSLMDEAV 277
Query: 291 GEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY-----KMSMYEASAHVPLLMMGPGI 345
G + AL L T+ I+S+D+G + + K S++E + P +
Sbjct: 278 GNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
Query: 346 K-AGLQVSNVVSLVDIYPTMLDIA 368
K G++ ++ + D PT++ +A
Sbjct: 338 KQKGVKNRELIHISDWLPTLVKLA 361
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 38.9 bits (89), Expect = 0.012
Identities = 29/110 (26%), Positives = 50/110 (45%), Gaps = 7/110 (6%)
Query: 32 PNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGL 91
PN V++++D ++ ++ M + G F++ + + C PSRA++ +G
Sbjct: 36 PNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLTGR 95
Query: 92 FTHLTESWNNFK-----GLDPNYTTWMDVMERHGYRTQKFGKLDYTSGHH 136
NF GL N TT +V+++ GY T GK + GHH
Sbjct: 96 LGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGK--WHLGHH 143
Score = 32.3 bits (72), Expect = 1.1
Identities = 30/118 (25%), Positives = 55/118 (46%), Gaps = 20/118 (16%)
Query: 276 RAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG------ELAMEHRQFY---- 325
R+ Y A E D+++G+I + + + T + ++ D+G ELA F
Sbjct: 266 RSLYGAGLWEMDSLVGQIKDKVDHT-VKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQ 324
Query: 326 --------KMSMYEASAHVPLLMMGPG-IKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ 374
K + +E VP L PG + + + ++S++DI+PT++ +A LPQ
Sbjct: 325 TRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQ 382
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 35.8 bits (81), Expect = 0.10
Identities = 55/253 (21%), Positives = 93/253 (36%), Gaps = 47/253 (18%)
Query: 276 RAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY-----KMSMY 330
R Y AM D + I AL + +++I+SSD+G + K + +
Sbjct: 260 RRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYW 319
Query: 331 EASAHVPLLMMGPGIKAGLQVSN-VVSLVDIYPTMLDIAG--IPLPQNLSGYSLLPLSSE 387
E + P +K + S ++ + D YPT++ +AG L GY + P SE
Sbjct: 320 EGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISE 379
Query: 388 TFKNEHK--VKNLHPPW------ILSEFHGCNVNASTYMLRTNHWKYIAYSDGAS--ILP 437
+ + N+ P + L G A +R WK + G I P
Sbjct: 380 GRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPP 439
Query: 438 Q-----------------------LFDLSSDPDELTNVAVKFPEITYSLDQKLHSI---- 470
Q LF++S+DP E ++A + P++ +L +L
Sbjct: 440 QTLATFPGSWWNLERMASVRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTA 499
Query: 471 --INYPKVSASVH 481
+ YP + H
Sbjct: 500 IPVRYPAENPRAH 512
Score = 34.7 bits (78), Expect = 0.23
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 10/118 (8%)
Query: 19 PG-AGEQRRRAA-KAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNAYTN 76
PG AGEQ A + P+++ +++D + GS + + P ++ + +G N Y
Sbjct: 32 PGEAGEQPSAAPPQPPHIIFILTDDQGYHDVGYHGSDI-ETPTLDRLAAKGVKLENYYIQ 90
Query: 77 SPICCPSRAAMWSGLF-THLTESWNNFKGLDPN-----YTTWMDVMERHGYRTQKFGK 128
PIC PSR+ + +G + H + + PN T ++ GY T GK
Sbjct: 91 -PICTPSRSQLLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGK 147
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 35.4 bits (80), Expect = 0.13
Identities = 21/80 (26%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 53 QVVKLPFINFMKTRGTSFLNAYTNSPICCPSRAAMWSGL---FTHLTESWNNFKGLDPNY 109
++VK P I+ + + F NA+ +C PSR + +G T L + + ++ N+
Sbjct: 20 ELVKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNF 79
Query: 110 TTWMDVMERHGYRTQKFGKL 129
+T + +GY T GK+
Sbjct: 80 STIPQYFKENGYVTMSVGKV 99
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.417
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,038,050
Number of Sequences: 37866
Number of extensions: 930589
Number of successful extensions: 2146
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 22
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2041
Number of HSP's gapped (non-prelim): 84
length of query: 536
length of database: 18,247,518
effective HSP length: 107
effective length of query: 429
effective length of database: 14,195,856
effective search space: 6090022224
effective search space used: 6090022224
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.