Search of human proteins with 38505294

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38505294 voltage-dependent calcium channel alpha 1G subunit
isoform 15 [Homo sapiens]
         (1555 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38505294 voltage-dependent calcium channel alpha 1G subunit i...  3140   0.0  
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i...  2976   0.0  
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i...  2919   0.0  
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H...  1612   0.0  
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H...  1612   0.0  
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I...   818   0.0  
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I...   818   0.0  
gi|37622907 voltage-gated sodium channel type V alpha isoform a ...   268   4e-71
gi|150417969 voltage-gated sodium channel type V alpha isoform d...   268   4e-71
gi|150417967 voltage-gated sodium channel type V alpha isoform c...   268   4e-71
gi|237512980 voltage-gated sodium channel type V alpha isoform e...   266   1e-70
gi|30089970 voltage-gated sodium channel type V alpha isoform b ...   266   1e-70
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ...   175   3e-43
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E...   175   3e-43
gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F...   165   3e-40
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1...   160   7e-39
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s...   158   4e-38
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s...   158   4e-38

>gi|38505294 voltage-dependent calcium channel alpha 1G subunit
            isoform 15 [Homo sapiens]
          Length = 1555

 Score = 3140 bits (8142), Expect = 0.0
 Identities = 1555/1555 (100%), Positives = 1555/1555 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA 1500
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQVSPRLRGGAVVKEAGGGTGPCLVIPA 1500

Query: 1501 DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG 1555
            DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG
Sbjct: 1501 DSGGGGLHEEISPSHPLLSNHQHVAKPSPSHSAPKSGPMGSLAVLKDEETEAQRG 1555


>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
            isoform 1 [Homo sapiens]
          Length = 2377

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1761 GVELFGDL 1768



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863


>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
            isoform 10 [Homo sapiens]
          Length = 2266

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1592 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1651

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1652 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1711

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1712 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1771

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1772 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1831

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1832 LMKHLEESNKEAKEEA 1847



 Score =  105 bits (261), Expect = 4e-22
 Identities = 67/212 (31%), Positives = 118/212 (55%), Gaps = 15/212 (7%)

Query: 1225 DDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLV 1284
            ++E    + +R+R   + R  A C  +  +S Y     SRFRLL H + T    D  +  
Sbjct: 1549 EEEARRREEKRLRRLEKKRRKAQC--KPYYSDY-----SRFRLLVHHLCTSHYLDLFITG 1601

Query: 1285 IIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRS 1344
            +I LN +T+AME  +  P   +   L + NYIFT +F+ E   K+VA    FG + + + 
Sbjct: 1602 VIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFVLESVFKLVA----FGFRRFFQD 1655

Query: 1345 SWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVV 1402
             WN LD  +VL+S++ I +  +  + +  +   ++R++R+LR  R L+++  A G++ ++
Sbjct: 1656 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALL 1715

Query: 1403 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1716 DTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1747



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1602 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1654

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1655 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1714

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1715 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1750



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1745 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1804

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1805 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1845


>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
            isoform 4 [Homo sapiens]
          Length = 2332

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1761 GVELFGDL 1768



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863


>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
            isoform 8 [Homo sapiens]
          Length = 2284

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1610 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1669

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1670 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1729

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1730 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1789

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1790 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1849

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1850 LMKHLEESNKEAKEEA 1865



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1598 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1655

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1656 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1711

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1712 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1765



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1548 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1593

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1594 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1643

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1644 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1700

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1701 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1760

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1761 GVELFGDL 1768



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1763 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1822

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1823 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1863


>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
            isoform 5 [Homo sapiens]
          Length = 2321

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1599 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1658

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1659 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1718

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1719 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1778

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1779 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1838

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1839 LMKHLEESNKEAKEEA 1854



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1587 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1644

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1645 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1661

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1662 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1721

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1722 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852


>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
            isoform 9 [Homo sapiens]
          Length = 2273

 Score = 2976 bits (7716), Expect = 0.0
 Identities = 1474/1474 (100%), Positives = 1474/1474 (100%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1265 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1321

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1442 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1501

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1502 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1599 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1658

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1659 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1718

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1719 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1778

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1779 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1838

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1839 LMKHLEESNKEAKEEA 1854



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1587 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1644

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1645 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1700

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1701 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1754



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1609 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1661

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1662 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1721

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1722 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1757



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1453 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1512

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1513 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1563



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1752 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1811

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1812 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1852


>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
            isoform 3 [Homo sapiens]
          Length = 2343

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829


>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
            isoform 13 [Homo sapiens]
          Length = 2243

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1569 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1628

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1629 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1688

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1689 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1748

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1749 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1808

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1809 LMKHLEESNKEAKEEA 1824



 Score =  105 bits (261), Expect = 4e-22
 Identities = 67/212 (31%), Positives = 118/212 (55%), Gaps = 15/212 (7%)

Query: 1225 DDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLV 1284
            ++E    + +R+R   + R  A C  +  +S Y     SRFRLL H + T    D  +  
Sbjct: 1526 EEEARRREEKRLRRLEKKRRKAQC--KPYYSDY-----SRFRLLVHHLCTSHYLDLFITG 1578

Query: 1285 IIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRS 1344
            +I LN +T+AME  +  P   +   L + NYIFT +F+ E   K+VA    FG + + + 
Sbjct: 1579 VIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFVLESVFKLVA----FGFRRFFQD 1632

Query: 1345 SWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVV 1402
             WN LD  +VL+S++ I +  +  + +  +   ++R++R+LR  R L+++  A G++ ++
Sbjct: 1633 RWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALL 1692

Query: 1403 ETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1693 DTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1724



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1579 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1631

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1632 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1691

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1692 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1727



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1722 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1781

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1782 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1822


>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
            isoform 12 [Homo sapiens]
          Length = 2250

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829


>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
            isoform 6 [Homo sapiens]
          Length = 2306

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1738 GVELFGDL 1745



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840


>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
            isoform 11 [Homo sapiens]
          Length = 2261

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1738 GVELFGDL 1745



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840


>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
            isoform 7 [Homo sapiens]
          Length = 2298

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829


>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
            isoform 2 [Homo sapiens]
          Length = 2354

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1587 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1646

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1647 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1706

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1707 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1766

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1767 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1826

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1827 LMKHLEESNKEAKEEA 1842



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1575 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1632

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1633 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1688

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1689 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1742



 Score = 68.2 bits (165), Expect = 6e-11
 Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 41/248 (16%)

Query: 3    EEEDGAGAEESG-----QPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALA 57
            EEE+    EE       + R  + L+D+  +G             SA SEA+  PY    
Sbjct: 1525 EEEEARRREEKRLRRLEKKRRNLMLDDVIASGSS----------ASAASEAQCKPY---- 1570

Query: 58   PVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRIL 117
                   S  SR R        + + +     VI LN VT+ M    +    D      L
Sbjct: 1571 ------YSDYSRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEA----L 1620

Query: 118  QAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS 177
            +  +      F +E V K+VA   FG + +  D WN+LD  IV+  ++  +L+   V+ S
Sbjct: 1621 KICNYIFTVIFVLESVFKLVA---FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNAS 1677

Query: 178  A---------VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 228
                      +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFIF  +
Sbjct: 1678 LPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAAL 1737

Query: 229  GVQLWAGL 236
            GV+L+  L
Sbjct: 1738 GVELFGDL 1745



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1740 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1799

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1800 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1840


>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
            isoform 14 [Homo sapiens]
          Length = 2171

 Score = 2919 bits (7567), Expect = 0.0
 Identities = 1451/1474 (98%), Positives = 1451/1474 (98%), Gaps = 23/1474 (1%)

Query: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60
            MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV
Sbjct: 1    MDEEEDGAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVV 60

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF
Sbjct: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120

Query: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180
            DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR
Sbjct: 121  DDFIFAFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVR 180

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR
Sbjct: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL
Sbjct: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM
Sbjct: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360

Query: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420
            YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA
Sbjct: 361  YFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNA 420

Query: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480
            STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS
Sbjct: 421  STLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSS 480

Query: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540
            SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP
Sbjct: 481  SCSRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTP 540

Query: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600
            ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE
Sbjct: 541  ALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE 600

Query: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660
            TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG
Sbjct: 601  TLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSG 660

Query: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720
            ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA
Sbjct: 661  ACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDA 720

Query: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780
            EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI
Sbjct: 721  EPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNI 780

Query: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840
            VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR
Sbjct: 781  VFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMR 840

Query: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900
            VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL
Sbjct: 841  VLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTL 900

Query: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960
            PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV
Sbjct: 901  PDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLV 960

Query: 961  AILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
            AILVEGFQAE                       GDANKSESEPDFFSPSLDGDGDRKKCL
Sbjct: 961  AILVEGFQAE-----------------------GDANKSESEPDFFSPSLDGDGDRKKCL 997

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1080
            ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA
Sbjct: 998  ALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAA 1057

Query: 1081 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1140
            HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ
Sbjct: 1058 HEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQ 1117

Query: 1141 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1200
            DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN
Sbjct: 1118 DEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCN 1177

Query: 1201 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1260
            GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP
Sbjct: 1178 GKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFP 1237

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV
Sbjct: 1238 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1297

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL
Sbjct: 1298 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1357

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1440
            RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV
Sbjct: 1358 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFV 1417

Query: 1441 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ
Sbjct: 1418 CQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1451



 Score =  108 bits (269), Expect = 5e-23
 Identities = 77/296 (26%), Positives = 147/296 (49%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE-QPEELTNA-LEISNIVFTSLF 786
            +RL+C    +I+  K F   +++ I +N +++ +E  +  P       L +SN +FT++F
Sbjct: 1242 FRLLC---HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVF 1298

Query: 787  ALEMLLKLLV----YGPFGYIKNPYNIFDGVIVVISVWEI----VGQQG----GGLSVLR 834
              EM +K++     +G   Y+++ +N+ DG++V+ISV +I    V   G    G L VLR
Sbjct: 1299 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1358

Query: 835  TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
              R +R L+++     L+  +  LM ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1359 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1418

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-- 936
            +  DT                +  + NFD+L  A++++F + +++ W  ++Y+G+ +   
Sbjct: 1419 QGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGV 1478

Query: 937  --------SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                    + W  LYFI+ +    + + N+ V ++VE F       + EE  +RE+
Sbjct: 1479 DQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1534



 Score =  107 bits (266), Expect = 1e-22
 Identities = 67/256 (26%), Positives = 131/256 (51%), Gaps = 19/256 (7%)

Query: 742  SKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFG 801
            S Y    I   I +N ++M +E+++QP+ L  AL+I N +FT +F LE + KL+ +G   
Sbjct: 1576 SHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRR 1635

Query: 802  YIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPAL 851
            + ++ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL++    +
Sbjct: 1636 FFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGM 1695

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE-RDGDTLPDRKNFDSLL 910
            +  L  +M+ +  V    +L ML  FIF+ LG+ LFG     E    + L     F +  
Sbjct: 1696 RALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFG 1755

Query: 911  WAIVTVFQILTQEDWNKVLYNGMASTSSWAA--------LYFIALMTFGNYVLFNLLVAI 962
             A +T+F++ T ++WN ++ + +      +         +YF++ +    +VL N+++A+
Sbjct: 1756 MAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFVLTAQFVLVNVVIAV 1815

Query: 963  LVEGFQAEEISKREDA 978
            L++  +      +E+A
Sbjct: 1816 LMKHLEESNKEAKEEA 1831



 Score =  103 bits (256), Expect = 2e-21
 Identities = 59/174 (33%), Positives = 102/174 (58%), Gaps = 8/174 (4%)

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            SRFRLL H + T    D  +  +I LN +T+AME  +  P   +   L + NYIFT +F+
Sbjct: 1564 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQ-QPQILDEA-LKICNYIFTVIFV 1621

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVL 1380
             E   K+VA    FG + + +  WN LD  +VL+S++ I +  +  + +  +   ++R++
Sbjct: 1622 LESVFKLVA----FGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIM 1677

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            R+LR  R L+++  A G++ +++T+M +L  +GN+ ++    F IF  LGV+LF
Sbjct: 1678 RVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELF 1731



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 48/156 (30%), Positives = 77/156 (49%), Gaps = 16/156 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            VI LN VT+ M    +    D      L+  +      F +E V K+VA   FG + +  
Sbjct: 1586 VIGLNVVTMAMEHYQQPQILDEA----LKICNYIFTVIFVLESVFKLVA---FGFRRFFQ 1638

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   V+ S          +R +R+ R L+ +     MR L
Sbjct: 1639 DRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRAL 1698

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            +  ++  LP +GN+ LL   +FFIF  +GV+L+  L
Sbjct: 1699 LDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDL 1734



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 32/111 (28%), Positives = 63/111 (56%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C+   +   +   NFDN+G A +++F + + +GWVDIMY  +DA          H+ +
Sbjct: 1430 SDCAEASYRWVRHKYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGVDQQPIMNHNPW 1489

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ +FF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1490 MLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREEKRLRRL 1540



 Score = 35.8 bits (81), Expect = 0.33
 Identities = 22/101 (21%), Positives = 45/101 (44%), Gaps = 11/101 (10%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM----DAHSFY 370
            + + +    E +P +G      F N G A++ +F+V T + W  IM   +       + Y
Sbjct: 1729 ELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCY 1788

Query: 371  NF----IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            N     IYF+  ++   F ++N+ + V+     E+ +   +
Sbjct: 1789 NTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAKE 1829


>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform b [Homo sapiens]
          Length = 2347

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 897/1524 (58%), Positives = 1029/1524 (67%), Gaps = 114/1524 (7%)

Query: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85

Query: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145

Query: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205

Query: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265

Query: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322

Query: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382

Query: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442

Query: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500

Query: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555

Query: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615

Query: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670

Query: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730

Query: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790

Query: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850

Query: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910

Query: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970

Query: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021

Query: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067

Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125

Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185

Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228

Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288

Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348

Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408

Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468

Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQ 1474
             K+ C  A YRWVR KYNFDNLGQ
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQ 1492



 Score =  119 bits (298), Expect = 2e-26
 Identities = 106/416 (25%), Positives = 188/416 (45%), Gaps = 42/416 (10%)

Query: 735  TFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKL 794
            +   +  S Y    I   I VN ++M +E++ QP+ L  AL+  N VFT +F  E  LKL
Sbjct: 1603 SIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKL 1662

Query: 795  LVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKL 844
            + +G   + K+ +N  D  IV++S+  I  ++             + ++R  R+ RVLKL
Sbjct: 1663 VAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKL 1722

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG-DTLPDR 903
            ++    ++  L  +++ +  V    +L ML  FI++ LG+ LFG    SE +  + L   
Sbjct: 1723 LKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGRLECSEDNPCEGLSRH 1782

Query: 904  KNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTS-----------SWAALYFIALMTFGN 952
              F +   A +T+F++ T ++WN ++ + +   S           + + +YF+  +    
Sbjct: 1783 ATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQ 1842

Query: 953  YVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDG 1012
            +VL N++VA+L++  +      REDA      I+L +    G A + +++         G
Sbjct: 1843 FVLVNVVVAVLMKHLEESNKEAREDAELDAE-IELEMAQGPGSARRVDADRPPLPQESPG 1901

Query: 1013 DGDRKKCLA-------LVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPA 1065
              D    +A       ++SL     + + ++P    H    P+   +  + G G  LG  
Sbjct: 1902 ARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPASAPH--PRPLQEVEMETYGAGTPLG-- 1957

Query: 1066 SRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKR 1121
            S  +  S  AE  A+ ++   P A SSP     A S       S     R+PSL R
Sbjct: 1958 SVASVHSPPAESCASLQI---PLAVSSP-----ARSGEPLHALSPRGTARSPSLSR 2005



 Score =  114 bits (284), Expect = 1e-24
 Identities = 76/288 (26%), Positives = 148/288 (51%), Gaps = 47/288 (16%)

Query: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLFALEMLLKL 794
            +K++  K F   +++ I +N +++ +E  +     T    L +SN +FT++F  EM++K+
Sbjct: 1288 QKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKV 1347

Query: 795  ----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFRLMRVLKLV 845
                L+ G   Y+++ +N+ DG++V++S+ +IV      GG   L VLR  RL+R L+ +
Sbjct: 1348 VALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPL 1407

Query: 846  RFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT--- 899
            R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF      DT   
Sbjct: 1408 RVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNI 1467

Query: 900  -------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST---------- 936
                         +  + NFD+L  A++++F + +++ W  ++Y+G+ +           
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527

Query: 937  SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
            + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 53/167 (31%), Positives = 95/167 (56%), Gaps = 8/167 (4%)

Query: 1270 HRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKV 1329
            H + T    D  +  II +N IT++ME     P S +   L   NY+FT VF+ E  +K+
Sbjct: 1605 HSLCTSHYLDLFITFIICVNVITMSMEHYN-QPKSLDEA-LKYCNYVFTIVFVFEAALKL 1662

Query: 1330 VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLR 1387
            VA    FG + + +  WN LD  +VL+S++ I +  +  S    +   ++R++R+LR  R
Sbjct: 1663 VA----FGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIAR 1718

Query: 1388 PLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
             L+++  A G++ +++T++ +L  +GN+ ++    F I+  LGV+LF
Sbjct: 1719 VLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 23/183 (12%)

Query: 67   DSRPRSWCLRTVCNP-WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
            D  P    + ++C   + +     +I +N +T+ M    +  + D         + +++F
Sbjct: 1596 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL-----KYCNYVF 1650

Query: 126  AF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA------ 178
               F  E  +K+VA   FG + +  D WN+LD  IV+  ++   + L+ +  SA      
Sbjct: 1651 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1705

Query: 179  -----VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
                 +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFI+  +GV+L+
Sbjct: 1706 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1765

Query: 234  AGL 236
              L
Sbjct: 1766 GRL 1768



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 14/109 (12%)

Query: 323  CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNF 372
            C A  +   +   NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
            +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581



 Score = 38.5 bits (88), Expect = 0.051
 Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 14/100 (14%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM------DAHS 368
            + +      E NP +G      F N G A++ +F+V T + W  IM   +      D H 
Sbjct: 1763 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1822

Query: 369  FYNF-----IYFILLIIVGSFFMINLCLVVIATQFSETKQ 403
                     +YF+  ++V  F ++N+ + V+     E+ +
Sbjct: 1823 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1862


>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
            subunit isoform a [Homo sapiens]
          Length = 2353

 Score = 1612 bits (4174), Expect = 0.0
 Identities = 897/1524 (58%), Positives = 1029/1524 (67%), Gaps = 114/1524 (7%)

Query: 7    GAGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQ 66
            GA  E  G P          G      P +AE+       E + +PYPALA  VFF L Q
Sbjct: 27   GASPESPGAPGREAERGSELGVSPSESP-AAERGAELGADEEQRVPYPALAATVFFCLGQ 85

Query: 67   DSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA 126
             +RPRSWCLR VCNPWFE +SMLVI+LNCVTLGMFRPCED+ C S+RC IL+AFD FIFA
Sbjct: 86   TTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFA 145

Query: 127  FFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
            FFAVEMV+KMVALG+FG+KCYLGDTWNRLDFFIV+AGM+EYSLD  NVS SA+RTVRVLR
Sbjct: 146  FFAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLR 205

Query: 187  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
            PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFL   
Sbjct: 206  PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLDSA 265

Query: 247  FSLPLSVDLER-YYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAY 305
            F    ++   R YYQTE  +E+PFICS  R+NGM+ C  +P   G      PC L +EAY
Sbjct: 266  FVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIP---GRRELRMPCTLGWEAY 322

Query: 306  NS-------SSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                     ++   C+NWNQYY  C +G+ NP  GAINFDNIGYAWIAIFQVITLEGWVD
Sbjct: 323  TQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGWVD 382

Query: 359  IMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLS 418
            IMY+VMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR R LS
Sbjct: 383  IMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLS 442

Query: 419  NASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQP 478
            N STLASFSEPGSCYEELLKY+ +I RK  RR  ++      R      P+ + GQ   P
Sbjct: 443  NDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQGQG--P 500

Query: 479  SSSCSRSHRRL-SVHHLV-HHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPP 536
                 R+ R   SVHHLV HHHHHHHHHYH  +G+ R P   P   D     +R +    
Sbjct: 501  GHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACD-----TRLVRAGA 555

Query: 537  PSTPALSGAPPGGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR---TVGSGKV-YPT 592
            P +P   G  P  AESVHS YHADCH+E  + +A    + + A+       G G + YPT
Sbjct: 556  PPSPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPT 615

Query: 593  V----------HTSPPPETLKEKALVEVAASSGPPTLTSLNIPPGPYSSMHKLLETQSTG 642
            +           TSP P+  K           GP +L S    P PY  +  ++     G
Sbjct: 616  ILPSGVGSGKGSTSPGPKG-KWAGGPPGTGGHGPLSLNS----PDPYEKIPHVVGEHGLG 670

Query: 643  ACQSSCK-ISSPCL----KADSGACGPDSCPYCARAGAG-EVELADREMPDSDSEAVYEF 696
                    +S PC      A +  C   SCPYC RA    E EL+  E  DSD   VYEF
Sbjct: 671  QAPGHLSGLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEF 730

Query: 697  TQDAQHSDLRDPH----------------SRRQRSLGPDAEPSSVLAFWRLICDTFRKIV 740
            TQD +H D  DP                  RR +      EP  +   W       R+IV
Sbjct: 731  TQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIV 790

Query: 741  DSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPF 800
            DSKYF RGIM+AILVNTLSMG+EYHEQPEELTNALEISNIVFTS+FALEMLLKLL  GP 
Sbjct: 791  DSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPL 850

Query: 801  GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMK 860
            GYI+NPYNIFDG+IVVISVWEIVGQ  GGLSVLRTFRL+RVLKLVRFLPAL+RQLVVL+K
Sbjct: 851  GYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLVRFLPALRRQLVVLVK 910

Query: 861  TMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQI 919
            TMDNVATFC LLMLFIFIFSILGMHLFGCKF+ + D GDT+PDRKNFDSLLWAIVTVFQI
Sbjct: 911  TMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQI 970

Query: 920  LTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS 979
            LTQEDWN VLYNGMASTSSWAALYF+ALMTFGNYVLFNLLVAILVEGFQAE         
Sbjct: 971  LTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAE--------- 1021

Query: 980  GQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDR---------KKCLALVSLGEHPE 1030
                          GDAN+S+++ D  S   + D  +         K C   V+   H E
Sbjct: 1022 --------------GDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNGHLE 1067

Query: 1031 LRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSAR 1090
             R SL PPLI+ TAATPM  PKS+         P SRR SSS    P    + K P S R
Sbjct: 1068 GRGSLSPPLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPP--LGDQKPPASLR 1125

Query: 1091 SSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEER 1150
            SSP +PW  + +W+SRRSS +SLGRAPSLKRR   GER SLLSGEG+ S D+E       
Sbjct: 1126 SSPCAPWGPSGAWSSRRSSWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAA 1185

Query: 1151 ASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLAR 1210
              P  +  R   SL+        LP T                 + +D +G+  +     
Sbjct: 1186 PGPRATPLRRAESLDPRPLRPAALPPT-----------------KCRDRDGQVVALPSDF 1228

Query: 1211 ALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCH 1270
             LR D    D  + DD+   S   R+   +    P  C  R++W+ Y+F PQ+RFR+ C 
Sbjct: 1229 FLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ 1288

Query: 1271 RIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVV 1330
            ++ITHKMFDHVVLV IFLNC+TIA+ERP IDP S ER+FL++SNYIFTA+F+AEM VKVV
Sbjct: 1289 KVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKVV 1348

Query: 1331 ALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLR 1390
            ALG   GE AYL+SSWN+LDGLLVL+S++DI+V+M S  G KILG+LRVLRLLRTLRPLR
Sbjct: 1349 ALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPLR 1408

Query: 1391 VISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNIT 1450
            VISRA GLKLVVETL+SSL+PIGNIV+ICCAFFIIFGILGVQLFKGKF+ C+G DTRNI+
Sbjct: 1409 VISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468

Query: 1451 NKSDCAEASYRWVRHKYNFDNLGQ 1474
             K+ C  A YRWVR KYNFDNLGQ
Sbjct: 1469 TKAQCRAAHYRWVRRKYNFDNLGQ 1492



 Score =  122 bits (306), Expect = 3e-27
 Identities = 113/442 (25%), Positives = 199/442 (45%), Gaps = 44/442 (9%)

Query: 711  RRQRSL--GPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQP 768
            RR+RS    P+A+     A +     +   +  S Y    I   I VN ++M +E++ QP
Sbjct: 1583 RRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQP 1642

Query: 769  EELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ-- 826
            + L  AL+  N VFT +F  E  LKL+ +G   + K+ +N  D  IV++S+  I  ++  
Sbjct: 1643 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1702

Query: 827  --------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFI 878
                       + ++R  R+ RVLKL++    ++  L  +++ +  V    +L ML  FI
Sbjct: 1703 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1762

Query: 879  FSILGMHLFGCKFASERDG-DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTS 937
            ++ LG+ LFG    SE +  + L     F +   A +T+F++ T ++WN ++ + +   S
Sbjct: 1763 YAALGVELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECS 1822

Query: 938  -----------SWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQ 986
                       + + +YF+  +    +VL N++VA+L++  +      REDA      I+
Sbjct: 1823 REDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAREDAELDAE-IE 1881

Query: 987  LPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLA-------LVSLGEHPELRKSLLPPL 1039
            L +    G A + +++         G  D    +A       ++SL     + + ++P  
Sbjct: 1882 LEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLPNDSYMFRPVVPAS 1941

Query: 1040 IIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSA 1099
              H    P+   +  + G G  LG  S  +  S  AE  A+ ++   P A SSP     A
Sbjct: 1942 APH--PRPLQEVEMETYGAGTPLG--SVASVHSPPAESCASLQI---PLAVSSP-----A 1989

Query: 1100 ASSWTSRRSSRNSLGRAPSLKR 1121
             S       S     R+PSL R
Sbjct: 1990 RSGEPLHALSPRGTARSPSLSR 2011



 Score =  114 bits (284), Expect = 1e-24
 Identities = 76/288 (26%), Positives = 148/288 (51%), Gaps = 47/288 (16%)

Query: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLFALEMLLKL 794
            +K++  K F   +++ I +N +++ +E  +     T    L +SN +FT++F  EM++K+
Sbjct: 1288 QKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAIFVAEMMVKV 1347

Query: 795  ----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFRLMRVLKLV 845
                L+ G   Y+++ +N+ DG++V++S+ +IV      GG   L VLR  RL+R L+ +
Sbjct: 1348 VALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRTLRPL 1407

Query: 846  RFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT--- 899
            R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF      DT   
Sbjct: 1408 RVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNI 1467

Query: 900  -------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST---------- 936
                         +  + NFD+L  A++++F + +++ W  ++Y+G+ +           
Sbjct: 1468 STKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNH 1527

Query: 937  SSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
            + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 1528 NPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1575



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 64/211 (30%), Positives = 112/211 (53%), Gaps = 15/211 (7%)

Query: 1226 DEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVI 1285
            +E  L + ER R   R+  P+   +R  + A   P +     LC    T    D  +  I
Sbjct: 1574 EEKRLRRLERRR---RSTFPSPEAQRRPYYADYSPTRRSIHSLC----TSHYLDLFITFI 1626

Query: 1286 IFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSS 1345
            I +N IT++ME     P S +   L   NY+FT VF+ E  +K+VA    FG + + +  
Sbjct: 1627 ICVNVITMSMEHYN-QPKSLDEA-LKYCNYVFTIVFVFEAALKLVA----FGFRRFFKDR 1680

Query: 1346 WNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLLRTLRPLRVISRAQGLKLVVE 1403
            WN LD  +VL+S++ I +  +  S    +   ++R++R+LR  R L+++  A G++ +++
Sbjct: 1681 WNQLDLAIVLLSLMGITLEEIEMSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLD 1740

Query: 1404 TLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            T++ +L  +GN+ ++    F I+  LGV+LF
Sbjct: 1741 TVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771



 Score = 64.3 bits (155), Expect = 9e-10
 Identities = 46/183 (25%), Positives = 87/183 (47%), Gaps = 23/183 (12%)

Query: 67   DSRPRSWCLRTVCNP-WFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
            D  P    + ++C   + +     +I +N +T+ M    +  + D         + +++F
Sbjct: 1602 DYSPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEAL-----KYCNYVF 1656

Query: 126  AF-FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSA------ 178
               F  E  +K+VA   FG + +  D WN+LD  IV+  ++   + L+ +  SA      
Sbjct: 1657 TIVFVFEAALKLVA---FGFRRFFKDRWNQLDLAIVLLSLM--GITLEEIEMSAALPINP 1711

Query: 179  -----VRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
                 +R +R+ R L+ +     MR L+  ++  LP +GN+ LL   +FFI+  +GV+L+
Sbjct: 1712 TIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF 1771

Query: 234  AGL 236
              L
Sbjct: 1772 GRL 1774



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 33/109 (30%), Positives = 61/109 (55%), Gaps = 14/109 (12%)

Query: 323  CSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNF 372
            C A  +   +   NFDN+G A +++F + + +GWV+IMY  +DA          H+ +  
Sbjct: 1473 CRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQPVQNHNPWML 1532

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
            +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1533 LYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1581



 Score = 38.5 bits (88), Expect = 0.051
 Identities = 23/100 (23%), Positives = 43/100 (43%), Gaps = 14/100 (14%)

Query: 318  QYYTNCSAGEHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIMYFVM------DAHS 368
            + +      E NP +G      F N G A++ +F+V T + W  IM   +      D H 
Sbjct: 1769 ELFGRLECSEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSREDKHC 1828

Query: 369  FYNF-----IYFILLIIVGSFFMINLCLVVIATQFSETKQ 403
                     +YF+  ++V  F ++N+ + V+     E+ +
Sbjct: 1829 LSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNK 1868


>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform b [Homo sapiens]
          Length = 2188

 Score =  818 bits (2114), Expect = 0.0
 Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)

Query: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 512  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 568

Query: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 569  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 628

Query: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 629  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 688

Query: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 689  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 748

Query: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 749  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 808

Query: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 809  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 845

Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 846  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 888

Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 889  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 948

Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 949  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1002

Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1003 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1062

Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1063 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1121

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1122 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1181

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1182 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1241

Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1242 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1301

Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQ
Sbjct: 1302 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1333



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84

Query: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144

Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204

Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264

Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321

Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381

Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440

Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472



 Score =  119 bits (298), Expect = 2e-26
 Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)

Query: 691  EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747
            E  ++  Q  +  + R    +R R L      +  L ++   C T      +  S Y   
Sbjct: 1397 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1456

Query: 748  GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807
             I   I +N ++M +E++ QP  L  AL+  N +FT++F LE +LKL+ +G   + K+ +
Sbjct: 1457 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1516

Query: 808  NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
            N  D  IV++SV  I  ++             + ++R  R+ RVLKL++    ++  L  
Sbjct: 1517 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1576

Query: 858  LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916
            +++ +  V    +L ML  FI++ LG+ LFG    + E   + +     F++   A +T+
Sbjct: 1577 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1636

Query: 917  FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965
            FQ+ T ++WN ++ +            ++S    + LYF++ +    +VL N++VA+L++
Sbjct: 1637 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1696

Query: 966  GFQAEEISKREDA 978
                     +EDA
Sbjct: 1697 HLDDSNKEAQEDA 1709



 Score =  114 bits (285), Expect = 7e-25
 Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786
            +R++C T   I+  K F   ++  I +N +++ +E  +     T    L +SN +FT++F
Sbjct: 1124 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1180

Query: 787  ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837
              EM LK+    L +G   Y+++ +N+ DG +V +S+ +IV      GG   L VLR  R
Sbjct: 1181 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1240

Query: 838  LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
            L+R L+ +R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1241 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1300

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933
               DT                +  + NFD+L  A++++F + +++ W  ++YNG+     
Sbjct: 1301 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1360

Query: 934  -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                  + + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 1361 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1416



 Score =  112 bits (279), Expect = 4e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 1116 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1172

Query: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 1173 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1232

Query: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 1233 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1292

Query: 233  WAG 235
            + G
Sbjct: 1293 FKG 1295



 Score =  103 bits (257), Expect = 1e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130

Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182

Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)

Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
            RLL H + T    D  +  II LN +T+++E     P S E   L   NY+FT VF+ E 
Sbjct: 1442 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1499

Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383
             +K+VA    FG + + +  WN LD  +VL+SV+ I +  +  +    +   ++R++R+L
Sbjct: 1500 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1555

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443
            R  R L+++  A G++ +++T++ +L  +GN+ ++    F I+  LGV+LF GK  VC  
Sbjct: 1556 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1613

Query: 1444 ED 1445
            E+
Sbjct: 1614 EN 1615



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 537 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 591

Query: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 592 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 647

Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 648 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 703

Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 704 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 749



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 1461 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1513

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 1514 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1573

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1574 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1612



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 1312 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1371

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1372 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1422



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 23/72 (31%), Positives = 44/72 (61%), Gaps = 2/72 (2%)

Query: 905 NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
           NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 339 NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398

Query: 965 EGFQAEEISKRE 976
             F   E  +RE
Sbjct: 399 TQF--SETKQRE 408



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 768 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 827

Query: 396 TQF 398
             F
Sbjct: 828 EGF 830



 Score = 38.1 bits (87), Expect = 0.067
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1613 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1672

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1673 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1707


>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
            subunit isoform a [Homo sapiens]
          Length = 2223

 Score =  818 bits (2114), Expect = 0.0
 Identities = 478/872 (54%), Positives = 567/872 (65%), Gaps = 108/872 (12%)

Query: 661  ACGPDSCPYCAR------AGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQR 714
            A  P SCP C        +G G  + + +E   S S A  E   +A     R        
Sbjct: 547  ASDPASCPCCQHEDGRRPSGLGSTD-SGQEGSGSGSSAGGE--DEADGDGARSSEDGASS 603

Query: 715  SLGPDAEPSSVLA--------FWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHE 766
             LG + E               WR      R IVDSKYF RGIM+AILVNT+SMGIE+HE
Sbjct: 604  ELGKEEEEEEQADGAVWLCGDVWRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHE 663

Query: 767  QPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQ 826
            QPEELTN LEI N+VFTS+FALEM+LKL  +G F Y++NPYNIFD +IV+IS+WEIVGQ 
Sbjct: 664  QPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQA 723

Query: 827  GGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHL 886
             GGLSVLRTFRL+RVLKLVRF+PAL+RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMH+
Sbjct: 724  DGGLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHI 783

Query: 887  FGCKFASERD-GDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFI 945
            FGCKF+   D GDT+PDRKNFDSLLWAIVTVFQILTQEDWN VLYNGMASTS WA+LYF+
Sbjct: 784  FGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFV 843

Query: 946  ALMTFGNYVLFNLLVAILVEGFQAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDF 1005
            ALMTFGNYVLFNLLVAILVEGFQAE                       GDAN+S S+ D 
Sbjct: 844  ALMTFGNYVLFNLLVAILVEGFQAE-----------------------GDANRSYSDEDQ 880

Query: 1006 FSPS----------LDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTS 1055
             S +          LD  GD K C   ++   H       L P          SLP    
Sbjct: 881  SSSNIEEFDKLQEGLDSSGDPKLCPIPMTPNGH-------LDP----------SLPLGGH 923

Query: 1056 TGLGEALGPASRRT-------------SSSGSAEPGAAHEMKSPPSARSSPHSPWSAASS 1102
             G   A GPA R +              SS  +    +++ +S  S+RSS + PW  +++
Sbjct: 924  LGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYGPWGRSAA 983

Query: 1103 WTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGE-GQESQDEEESSEE--ERASPAGSDH- 1158
            W SRRSS NSL      K + PS E  SLLS E G  ++  E +++E   RA+P  + H 
Sbjct: 984  WASRRSSWNSL------KHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHA 1037

Query: 1159 --------------RHRGSLEREAKSSFDLPDTLQVPGLHRTASGR--GSASEHQDCNGK 1202
                           HR +L  + + S DL + +   G H  A+ R  G A  H+DCNG+
Sbjct: 1038 HHIHHGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGR 1097

Query: 1203 SASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQ 1262
              S       +  D    G+D ++E + +   RVR  I    P  C  R+ WS Y+F P+
Sbjct: 1098 MPSIAKDVFTKMGDRGDRGED-EEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPE 1156

Query: 1263 SRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFL 1322
            +RFR+LC  II HK+FD+VVL  IFLNCITIA+ERP+I+  S ERIFLT+SNYIFTA+F+
Sbjct: 1157 NRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFV 1216

Query: 1323 AEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRL 1382
             EMT+KVV+LG  FGEQAYLRSSWNVLDG LV +S+IDI+VS+ S  G KILG+LRVLRL
Sbjct: 1217 GEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRL 1276

Query: 1383 LRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQ 1442
            LRTLRPLRVISRA GLKLVVETL+SSLKPIGNIV+ICCAFFIIFGILGVQLFKGKF+ C 
Sbjct: 1277 LRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCL 1336

Query: 1443 GEDTRNITNKSDCAEASYRWVRHKYNFDNLGQ 1474
            G DTRNITN+SDC  A+YRWV HKYNFDNLGQ
Sbjct: 1337 GVDTRNITNRSDCMAANYRWVHHKYNFDNLGQ 1368



 Score =  607 bits (1564), Expect = e-173
 Identities = 303/452 (67%), Positives = 352/452 (77%), Gaps = 16/452 (3%)

Query: 31  RPGPGSAEKDPGSADSEAEG----LPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERI 86
           +PGP S    P   +   +G    +P+P LAP+ FF L Q + PR+WC++ VCNPWFE +
Sbjct: 25  QPGPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECV 84

Query: 87  SMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKC 146
           SMLVILLNCVTLGM++PC+D+ C S RC+ILQ FDDFIF FFA+EMV+KMVALGIFGKKC
Sbjct: 85  SMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALGIFGKKC 144

Query: 147 YLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLD 206
           YLGDTWNRLDFFIV+AGM+EYSLDLQN++ SA+RTVRVLRPL+AINRVPSMRILV LLLD
Sbjct: 145 YLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLD 204

Query: 207 TLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDE 266
           TLPMLGNVLLLCFFVFFIFGI+GVQLWAGLLRNRCFL ENF++   V L  YYQ E +DE
Sbjct: 205 TLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDE 264

Query: 267 SPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL------DYEAYNSSSNTT--CVNWNQ 318
            PFICS   +NG+  C  +P L+     G  C L      D+ A     N +  CVNWN+
Sbjct: 265 MPFICSLSGDNGIMGCHEIPPLKEQ---GRECCLSKDDVYDFGAGRQDLNASGLCVNWNR 321

Query: 319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILL 378
           YY  C  G  NP KGAINFDNIGYAWI IFQVITLEGWV+IMY+VMDAHSFYNFIYFILL
Sbjct: 322 YYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILL 381

Query: 379 IIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLK 438
           IIVGSFFMINLCLVVIATQFSETKQRE +LM EQR R+LS +ST+AS++EPG CYEE+ +
Sbjct: 382 IIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLS-SSTVASYAEPGDCYEEIFQ 440

Query: 439 YLVYILRKAARRLAQVSRAAGVRVGLLSSPAP 470
           Y+ +ILRKA RR   + +A   R   L   AP
Sbjct: 441 YVCHILRKAKRRALGLYQALQSRRQALGPEAP 472



 Score =  119 bits (298), Expect = 2e-26
 Identities = 80/313 (25%), Positives = 151/313 (48%), Gaps = 25/313 (7%)

Query: 691  EAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRLICDT---FRKIVDSKYFGR 747
            E  ++  Q  +  + R    +R R L      +  L ++   C T      +  S Y   
Sbjct: 1432 ENFHKCRQHQEAEEARRREEKRLRRLEKKRRKAQRLPYYATYCHTRLLIHSMCTSHYLDI 1491

Query: 748  GIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPY 807
             I   I +N ++M +E++ QP  L  AL+  N +FT++F LE +LKL+ +G   + K+ +
Sbjct: 1492 FITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRW 1551

Query: 808  NIFDGVIVVISVWEIVGQQ----------GGGLSVLRTFRLMRVLKLVRFLPALQRQLVV 857
            N  D  IV++SV  I  ++             + ++R  R+ RVLKL++    ++  L  
Sbjct: 1552 NQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDT 1611

Query: 858  LMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFAS-ERDGDTLPDRKNFDSLLWAIVTV 916
            +++ +  V    +L ML  FI++ LG+ LFG    + E   + +     F++   A +T+
Sbjct: 1612 VVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFGMAFLTL 1671

Query: 917  FQILTQEDWNKVLYNG-----------MASTSSWAALYFIALMTFGNYVLFNLLVAILVE 965
            FQ+ T ++WN ++ +            ++S    + LYF++ +    +VL N++VA+L++
Sbjct: 1672 FQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMK 1731

Query: 966  GFQAEEISKREDA 978
                     +EDA
Sbjct: 1732 HLDDSNKEAQEDA 1744



 Score =  114 bits (285), Expect = 7e-25
 Identities = 81/296 (27%), Positives = 148/296 (50%), Gaps = 50/296 (16%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNA--LEISNIVFTSLF 786
            +R++C T   I+  K F   ++  I +N +++ +E  +     T    L +SN +FT++F
Sbjct: 1159 FRVLCQT---IIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIF 1215

Query: 787  ALEMLLKL----LVYGPFGYIKNPYNIFDGVIVVISVWEIV---GQQGGG--LSVLRTFR 837
              EM LK+    L +G   Y+++ +N+ DG +V +S+ +IV      GG   L VLR  R
Sbjct: 1216 VGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLR 1275

Query: 838  LMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASE 894
            L+R L+ +R +   P L+  +  L+ ++  +    ++   F  IF ILG+ LF  KF   
Sbjct: 1276 LLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHC 1335

Query: 895  RDGDT----------------LPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGM----- 933
               DT                +  + NFD+L  A++++F + +++ W  ++YNG+     
Sbjct: 1336 LGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAV 1395

Query: 934  -----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGF-------QAEEISKRED 977
                  + + W  LYFI+ +   ++ + N+ V ++VE F       +AEE  +RE+
Sbjct: 1396 DQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREE 1451



 Score =  112 bits (279), Expect = 4e-24
 Identities = 64/183 (34%), Positives = 106/183 (57%), Gaps = 12/183 (6%)

Query: 62   FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
            +  S ++R R  C   + +  F+ + +  I LNC+T+ + RP   I   S   RI     
Sbjct: 1151 YLFSPENRFRVLCQTIIAHKLFDYVVLAFIFLNCITIALERP--QIEAGSTE-RIFLTVS 1207

Query: 122  DFIF-AFFAVEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
            ++IF A F  EM +K+V+LG+ FG++ YL  +WN LD F+V   +++  + L +   + +
Sbjct: 1208 NYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSLASAGGAKI 1267

Query: 180  -------RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 232
                   R +R LRPLR I+R P ++++V  L+ +L  +GN++L+C   F IFGI+GVQL
Sbjct: 1268 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQL 1327

Query: 233  WAG 235
            + G
Sbjct: 1328 FKG 1330



 Score =  103 bits (257), Expect = 1e-21
 Identities = 56/171 (32%), Positives = 101/171 (59%), Gaps = 12/171 (7%)

Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAE---RIFLTLSNYIFTAVFLAEM 1325
            C +++ +  F+ V +++I LNC+T+ M +P  D        +I     ++IF   F  EM
Sbjct: 72   CIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMDCLSDRCKILQVFDDFIFI-FFAMEM 130

Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRT 1385
             +K+VALG  FG++ YL  +WN LD  +V+  +++  + + + +       L  +R +R 
Sbjct: 131  VLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNIN-------LSAIRTVRV 182

Query: 1386 LRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            LRPL+ I+R   ++++V  L+ +L  +GN++++C   F IFGI+GVQL+ G
Sbjct: 183  LRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAG 233



 Score = 96.7 bits (239), Expect = 2e-19
 Identities = 61/182 (33%), Positives = 104/182 (57%), Gaps = 10/182 (5%)

Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEM 1325
            RLL H + T    D  +  II LN +T+++E     P S E   L   NY+FT VF+ E 
Sbjct: 1477 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYN-QPTSLETA-LKYCNYMFTTVFVLEA 1534

Query: 1326 TVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG--MLRVLRLL 1383
             +K+VA    FG + + +  WN LD  +VL+SV+ I +  +  +    +   ++R++R+L
Sbjct: 1535 VLKLVA----FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVL 1590

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG 1443
            R  R L+++  A G++ +++T++ +L  +GN+ ++    F I+  LGV+LF GK  VC  
Sbjct: 1591 RIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELF-GK-LVCND 1648

Query: 1444 ED 1445
            E+
Sbjct: 1649 EN 1650



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 59/226 (26%), Positives = 104/226 (46%), Gaps = 13/226 (5%)

Query: 8   AGAEESGQPRSFMRLNDLSGAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQD 67
           +G E SG   S    ++  G G R     A  + G  + E E          V+      
Sbjct: 572 SGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKEEEEEEQAD-----GAVWLCGDVW 626

Query: 68  SRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF 127
              R+     V + +F R  M+ IL+N V++G+    E      +   IL+  +    + 
Sbjct: 627 RETRAKLRGIVDSKYFNRGIMMAILVNTVSMGI----EHHEQPEELTNILEICNVVFTSM 682

Query: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRP 187
           FA+EM++K+ A G+F    YL + +N  D  IVI  + E  +   +   S +RT R+LR 
Sbjct: 683 FALEMILKLAAFGLFD---YLRNPYNIFDSIIVIISIWEI-VGQADGGLSVLRTFRLLRV 738

Query: 188 LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
           L+ +  +P++R  + +L+ T+  +    +L     FIF I+G+ ++
Sbjct: 739 LKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIF 784



 Score = 65.5 bits (158), Expect = 4e-10
 Identities = 43/159 (27%), Positives = 82/159 (51%), Gaps = 16/159 (10%)

Query: 90   VILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLG 149
            +I LN VT+ +    +  + ++     L+  +      F +E V+K+VA   FG + +  
Sbjct: 1496 IICLNVVTMSLEHYNQPTSLETA----LKYCNYMFTTVFVLEAVLKLVA---FGLRRFFK 1548

Query: 150  DTWNRLDFFIVIAGMLEYSLDLQNVSFSA---------VRTVRVLRPLRAINRVPSMRIL 200
            D WN+LD  IV+  ++  +L+   ++ +          +R +R+ R L+ +     MR L
Sbjct: 1549 DRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRAL 1608

Query: 201  VTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 239
            +  ++  LP +GN+ LL   +FFI+  +GV+L+  L+ N
Sbjct: 1609 LDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCN 1647



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 45/161 (27%), Positives = 85/161 (52%), Gaps = 14/161 (8%)

Query: 738 KIVDSKYFGRGIMIAILVNTLSMGIEYHEQP-------EELTNALEISNIVFTSLFALEM 790
           K+V + +F    M+ IL+N +++G+    QP        +    L++ +      FA+EM
Sbjct: 74  KMVCNPWFECVSMLVILLNCVTLGMY---QPCDDMDCLSDRCKILQVFDDFIFIFFAMEM 130

Query: 791 LLKLLVYGPFG---YIKNPYNIFDGVIVVISVWEI-VGQQGGGLSVLRTFRLMRVLKLVR 846
           +LK++  G FG   Y+ + +N  D  IV+  + E  +  Q   LS +RT R++R LK + 
Sbjct: 131 VLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAIN 190

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF 887
            +P+++  + +L+ T+  +    +L     FIF I+G+ L+
Sbjct: 191 RVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 231



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 33/111 (29%), Positives = 62/111 (55%), Gaps = 14/111 (12%)

Query: 321  TNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFY 370
            ++C A  +       NFDN+G A +++F + + +GWV+IMY  +DA          H+ +
Sbjct: 1347 SDCMAANYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPW 1406

Query: 371  NFIYFILLIIVGSFFMINLCLVVIATQFSETKQ----RESQLMREQRVRFL 417
              +YFI  +++ SFF++N+ + V+   F + +Q     E++   E+R+R L
Sbjct: 1407 MLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRL 1457



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 70/279 (25%), Positives = 111/279 (39%), Gaps = 35/279 (12%)

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILV 964
            NFD++ +A + +FQ++T E W +++Y  M + S +  +YFI L+  G++ + NL + ++ 
Sbjct: 339  NFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 398

Query: 965  EGF----QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCL 1020
              F    Q E     E     LS   +   ++ GD    E    +    L     RK   
Sbjct: 399  TQFSETKQREHRLMLEQRQRYLSSSTVASYAEPGDC--YEEIFQYVCHIL-----RKAKR 451

Query: 1021 ALVSLGEHPELRKSLLPPLIIHTAAT-PMSLPKSTSTGLGEALGPASRRTSS------SG 1073
              + L +  + R+  L P     A   P +       G  +  G   R   S       G
Sbjct: 452  RALGLYQALQSRRQALGPEAPAPAKPGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHG 511

Query: 1074 SAEPGAAHE------MKSPPSARSSPHS-----PWSAASSWTSRRSSRNSLGRAPSLKRR 1122
             A PG  H         SP  A  +PH+     P + AS   S    ++  GR PS    
Sbjct: 512  PASPGNDHSGRELCPQHSPLDA--TPHTLVQPIPATLASDPASCPCCQHEDGRRPSGLGS 569

Query: 1123 SPSGER----RSLLSGEGQESQDEEESSEEERASPAGSD 1157
            + SG+      S   GE +   D   SSE+  +S  G +
Sbjct: 570  TDSGQEGSGSGSSAGGEDEADGDGARSSEDGASSELGKE 608



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 19/63 (30%), Positives = 39/63 (61%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIA 395
           NFD++ +A + +FQ++T E W  ++Y  M + S +  +YF+ L+  G++ + NL + ++ 
Sbjct: 803 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILV 862

Query: 396 TQF 398
             F
Sbjct: 863 EGF 865



 Score = 38.1 bits (87), Expect = 0.067
 Identities = 21/95 (22%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 327  EHNPFKGA---INFDNIGYAWIAIFQVITLEGWVDIM-----------YFVMDAHSFYNF 372
            + NP +G      F+N G A++ +FQV T + W  IM              + +  F + 
Sbjct: 1648 DENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQFVSP 1707

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQ 407
            +YF+  ++   F +IN+ + V+     ++ +   +
Sbjct: 1708 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQE 1742


>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
            sapiens]
          Length = 2016

 Score =  268 bits (684), Expect = 4e-71
 Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998

Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037

Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083

Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141

Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192

Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252

Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
            EM +K VA    +G + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
            R LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C  
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
              +G+   N T   NKS C   +      W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406



 Score =  144 bits (362), Expect = 9e-34
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  115 bits (287), Expect = 4e-25
 Identities = 175/829 (21%), Positives = 318/829 (38%), Gaps = 201/829 (24%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454

Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497

Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545

Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598

Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658

Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824

Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+
Sbjct: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458

Query: 953  YVLFNLLVAILVEGFQAEE 971
            +   NL + ++++ F  ++
Sbjct: 1459 FFTLNLFIGVIIDNFNQQK 1477



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 53/180 (29%), Positives = 88/180 (48%), Gaps = 17/180 (9%)

Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214

Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758

Query: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979
               ++ N+ +AI++E F        E  S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1569

Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1570 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1624

Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F
Sbjct: 1625 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1679



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|150417969 voltage-gated sodium channel type V alpha isoform d
            [Homo sapiens]
          Length = 1998

 Score =  268 bits (684), Expect = 4e-71
 Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998

Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037

Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083

Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141

Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192

Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252

Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
            EM +K VA    +G + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
            R LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C  
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
              +G+   N T   NKS C   +      W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406



 Score =  122 bits (305), Expect = 4e-27
 Identities = 108/387 (27%), Positives = 170/387 (43%), Gaps = 88/387 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLE-GWVDI 359
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV   +  W   
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVYEEQPQW--- 1422

Query: 360  MYFVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQLMREQRVRF 416
                   ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +   M E++ ++
Sbjct: 1423 ------EYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKY 1476

Query: 417  LSNASTLASFSEPGSCYEELLKYLVYI 443
             +    L S          L KY  +I
Sbjct: 1477 YNAMKKLGSKKPQKPIPRPLNKYQGFI 1503



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  114 bits (286), Expect = 6e-25
 Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
            G     F ++++P+N  D  VI++  V E +  + G LS LRTF   R ++ + ++  L 
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237

Query: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454

Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497

Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545

Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598

Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658

Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824

Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+
Sbjct: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214

Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 76/312 (24%), Positives = 146/312 (46%), Gaps = 56/312 (17%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398

Query: 905  --NFDSL---LWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLL 959
              NFD++     A++ V++   Q ++N  +Y           +YF+  + FG++   NL 
Sbjct: 1399 KVNFDNVGAGYLALLQVYEEQPQWEYNLYMY-----------IYFVIFIIFGSFFTLNLF 1447

Query: 960  VAILVEGFQAEE 971
            + ++++ F  ++
Sbjct: 1448 IGVIIDNFNQQK 1459



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1506 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1565

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1566 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1624

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1625 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1680

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1681 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1740

Query: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979
               ++ N+ +AI++E F        E  S
Sbjct: 1741 SFLIVVNMYIAIILENFSVATEESTEPLS 1769



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1495 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1551

Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1552 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1606

Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F
Sbjct: 1607 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1661



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1512 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1564

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1565 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1623

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1624 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1662



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|150417967 voltage-gated sodium channel type V alpha isoform c
            [Homo sapiens]
          Length = 2016

 Score =  268 bits (684), Expect = 4e-71
 Identities = 216/761 (28%), Positives = 352/761 (46%), Gaps = 73/761 (9%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998

Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037

Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
             P        P + A S T        NSLG                  S + QESQ   
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEE--------------SSKQQESQPVS 1083

Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1084 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1141

Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1142 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1192

Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1252

Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
            EM +K VA    +G + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR L
Sbjct: 1253 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1305

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
            R LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C  
Sbjct: 1306 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1365

Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
              +G+   N T   NKS C   +      W + K NFDN+G
Sbjct: 1366 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1406



 Score =  144 bits (362), Expect = 9e-34
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1193 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1248

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1249 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1303

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1304 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1362

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1363 CINQTEGDLPL------------------------------------------------- 1373

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1374 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1425

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1426 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1485

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1486 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1521



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  114 bits (286), Expect = 6e-25
 Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
            G     F ++++P+N  D  VI++  V E +  + G LS LRTF   R ++ + ++  L 
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237

Query: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454

Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497

Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545

Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598

Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658

Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824

Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+
Sbjct: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1160 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1218

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1219 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1278

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1279 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1338

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1339 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1398

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1399 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1458

Query: 953  YVLFNLLVAILVEGFQAEE 971
            +   NL + ++++ F  ++
Sbjct: 1459 FFTLNLFIGVIIDNFNQQK 1477



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214

Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1524 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1583

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1584 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1642

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1643 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1698

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1699 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1758

Query: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979
               ++ N+ +AI++E F        E  S
Sbjct: 1759 SFLIVVNMYIAIILENFSVATEESTEPLS 1787



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1569

Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1570 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1624

Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F
Sbjct: 1625 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1679



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1530 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1582

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1583 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1641

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1642 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1680



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|237512980 voltage-gated sodium channel type V alpha isoform e
            [Homo sapiens]
          Length = 1983

 Score =  266 bits (680), Expect = 1e-70
 Identities = 215/761 (28%), Positives = 351/761 (46%), Gaps = 74/761 (9%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998

Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037

Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
             P        P + A S T        NSLG      +               QESQ   
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082

Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140

Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191

Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251

Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
            EM +K VA    +G + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
            R LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C  
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364

Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
              +G+   N T   NKS C   +      W + K NFDN+G
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1405



 Score =  144 bits (362), Expect = 9e-34
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520



 Score =  120 bits (301), Expect = 1e-26
 Identities = 95/348 (27%), Positives = 165/348 (47%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I   +  ++ L N+S  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLGNLS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +P ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  114 bits (286), Expect = 6e-25
 Identities = 176/829 (21%), Positives = 319/829 (38%), Gaps = 201/829 (24%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTF---RLMRVLKLVRFLP 849
            G     F ++++P+N  D  VI++  V E +  + G LS LRTF   R ++ + ++  L 
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYVSENI--KLGNLSALRTFRVLRALKTISVIPGLK 237

Query: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454

Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497

Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545

Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598

Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658

Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824

Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+
Sbjct: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457

Query: 953  YVLFNLLVAILVEGFQAEE 971
            +   NL + ++++ F  ++
Sbjct: 1458 FFTLNLFIGVIIDNFNQQK 1476



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 53/180 (29%), Positives = 89/180 (49%), Gaps = 17/180 (9%)

Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
            FTA++  E  VK++A G+C     +LR  WN LD  +++++ +   +          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK---------LGN 214

Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            L  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  LSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 60/261 (22%), Positives = 107/261 (40%), Gaps = 49/261 (18%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F   +L  ++   
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGTVLSDIIQK- 1581

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVL 858
               Y  +P  +F                     V+R  R+ R+L+L+R    ++  L  L
Sbjct: 1582 ---YFFSP-TLF--------------------RVIRLARIGRILRLIRGAKGIRTLLFAL 1617

Query: 859  MKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAIVTVFQ 918
            M ++  +    +LL L +FI+SI GM      FA  +    + D  NF +   +++ +FQ
Sbjct: 1618 MMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFANSMLCLFQ 1673

Query: 919  ILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTFGNYVLFNL 958
            I T   W+ +L                      G   + +   L+F   +     ++ N+
Sbjct: 1674 ITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNM 1733

Query: 959  LVAILVEGFQAEEISKREDAS 979
             +AI++E F        E  S
Sbjct: 1734 YIAIILENFSVATEESTEPLS 1754



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 43/175 (24%), Positives = 74/175 (42%), Gaps = 41/175 (23%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1568

Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
            +F   +   ++        Q Y  S                               + RV
Sbjct: 1569 IFTGTVLSDII--------QKYFFSPT-----------------------------LFRV 1591

Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F
Sbjct: 1592 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1646



 Score = 41.2 bits (95), Expect = 0.008
 Identities = 23/59 (38%), Positives = 33/59 (55%)

Query: 176  FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
            F  +R  R+ R LR I     +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1589 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1647



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|30089970 voltage-gated sodium channel type V alpha isoform b [Homo
            sapiens]
          Length = 2015

 Score =  266 bits (680), Expect = 1e-70
 Identities = 215/761 (28%), Positives = 351/761 (46%), Gaps = 74/761 (9%)

Query: 729  WRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            W  I    + +V   +    I + I++NTL M +E++    E    L++ N+VFT +F  
Sbjct: 703  WMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTA 762

Query: 789  EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFL 848
            EM  K++   P+ Y +  +NIFD +IV++S+ E+   +   LSVLR+FRL+RV KL +  
Sbjct: 763  EMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMSNLSVLRSFRLLRVFKLAKSW 822

Query: 849  PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT-LPDRKNFD 907
            P L   + ++  ++  +    ++L + +FIF+++GM LFG  ++  RD D+ L  R +  
Sbjct: 823  PTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMM 882

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGM-ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
                A + +F+IL  E W + +++ M  S  S   L F+ +M  GN V+ NL +A+L+  
Sbjct: 883  DFFHAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSS 941

Query: 967  FQAEEISKREDASGQLSCIQLPVDS-QGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
            F A+ ++   D   +++ +QL +   Q G      +  DF    L      +K  AL + 
Sbjct: 942  FSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLL--RQRPQKPAALAAQ 998

Query: 1026 GEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKS 1085
            G+ P               ATP S P   +    E + P  + T      +PG     + 
Sbjct: 999  GQLPS------------CIATPYSPPPPET----EKVPPTRKETRFEEGEQPG-----QG 1037

Query: 1086 PPSARSSPHSPWSAASSWT--SRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEE 1143
             P        P + A S T        NSLG      +               QESQ   
Sbjct: 1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSK---------------QESQPVS 1082

Query: 1144 ESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKS 1203
               E    S   S      S E EA +S    D  Q       A G G   E     G +
Sbjct: 1083 GGPEAPPDSRTWSQVSATASSEAEASAS--QADWRQQWKAEPQAPGCGETPEDSCSEGST 1140

Query: 1204 ASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQS 1263
            A       L    P L  D  D E   ++G         R P C ++       ++    
Sbjct: 1141 ADMTNTAELLEQIPDLGQDVKDPEDCFTEG------CVRRCPCCAVDTTQAPGKVW---W 1191

Query: 1264 RFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLA 1323
            R R  C+ I+ H  F+  ++ +I L+   +A E   ++     ++ L  ++ +FT VF+ 
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVL 1251

Query: 1324 EMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLL 1383
            EM +K VA    +G + Y  ++W  LD L+V +S++ ++ + +   G   +G ++ LR L
Sbjct: 1252 EMLLKWVA----YGFKKYFTNAWCWLDFLIVDVSLVSLVANTL---GFAEMGPIKSLRTL 1304

Query: 1384 RTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC-- 1441
            R LRPLR +SR +G+++VV  L+ ++  I N++++C  F++IF I+GV LF GKF  C  
Sbjct: 1305 RALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCIN 1364

Query: 1442 --QGEDTRNIT---NKSDCAEASYR----WVRHKYNFDNLG 1473
              +G+   N T   NKS C   +      W + K NFDN+G
Sbjct: 1365 QTEGDLPLNYTIVNNKSQCESLNLTGELYWTKVKVNFDNVG 1405



 Score =  144 bits (362), Expect = 9e-34
 Identities = 115/396 (29%), Positives = 180/396 (45%), Gaps = 88/396 (22%)

Query: 69   RPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRC-RILQAFDDFIFAF 127
            R R  C   V + WFE   + +ILL+   L      EDI  + ++  ++L  + D +F +
Sbjct: 1192 RLRKTCYHIVEHSWFETFIIFMILLSSGALAF----EDIYLEERKTIKVLLEYADKMFTY 1247

Query: 128  -FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFS------AVR 180
             F +EM++K VA   +G K Y  + W  LDF IV   ++  SL    + F+      ++R
Sbjct: 1248 VFVLEMLLKWVA---YGFKKYFTNAWCWLDFLIVDVSLV--SLVANTLGFAEMGPIKSLR 1302

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNR 240
            T+R LRPLRA++R   MR++V  L+  +P + NVLL+C   + IF I+GV L+AG    R
Sbjct: 1303 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF-GR 1361

Query: 241  CFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGL 300
            C       LPL                                                 
Sbjct: 1362 CINQTEGDLPL------------------------------------------------- 1372

Query: 301  DYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 360
            +Y   N+ S    +N          GE    K  +NFDN+G  ++A+ QV T +GW+DIM
Sbjct: 1373 NYTIVNNKSQCESLN--------LTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIM 1424

Query: 361  YFVMDA----------HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR---ESQ 407
            Y  +D+          ++ Y +IYF++ II GSFF +NL + VI   F++ K++   +  
Sbjct: 1425 YAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDI 1484

Query: 408  LMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYI 443
             M E++ ++ +    L S          L KY  +I
Sbjct: 1485 FMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFI 1520



 Score =  118 bits (296), Expect = 4e-26
 Identities = 96/348 (27%), Positives = 163/348 (46%), Gaps = 36/348 (10%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFA 129
           R   ++ + +  F  + M  IL NCV +    P                + ++ F A + 
Sbjct: 121 RRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPP-----------WTKYVEYTFTAIYT 169

Query: 130 VEMVVKMVALGI-FGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPL 188
            E +VK++A G       +L D WN LDF ++I       +DL NVS  A+RT RVLR L
Sbjct: 170 FESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDLGNVS--ALRTFRVLRAL 227

Query: 189 RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFS 248
           + I+ +  ++ +V  L+ ++  L +V++L  F   +F ++G+QL+ G LR++C    NF+
Sbjct: 228 KTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCV--RNFT 285

Query: 249 LPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSS 308
                +          +      S P    +++  S   L         CG      NSS
Sbjct: 286 ALNGTNGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLL---------CG------NSS 330

Query: 309 SNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS 368
              TC    + Y    AGE NP  G  +FD+  +A++A+F+++T + W  +    + +  
Sbjct: 331 DAGTC---PEGYRCLKAGE-NPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAG 386

Query: 369 FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRF 416
               I+F+L+I +GSF+++NL L V+A  + E  Q       E+  RF
Sbjct: 387 KIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRF 434



 Score =  115 bits (287), Expect = 4e-25
 Identities = 175/829 (21%), Positives = 318/829 (38%), Gaps = 201/829 (24%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            KI+    F   IM  IL N + M       P   T  +E +   FT+++  E L+K+L  
Sbjct: 126  KILVHSLFNMLIMCTILTNCVFMA---QHDPPPWTKYVEYT---FTAIYTFESLVKILAR 179

Query: 798  G----PFGYIKNPYNIFD-GVIVVISVWEIVGQQGGGLSVLRTFRL---MRVLKLVRFLP 849
            G     F ++++P+N  D  VI++    E V    G +S LRTFR+   ++ + ++  L 
Sbjct: 180  GFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVDL--GNVSALRTFRVLRALKTISVISGLK 237

Query: 850  ALQRQLV--------VLMKTMDNVATFCML-LMLFI------------------------ 876
             +   L+        V++ T+  ++ F ++ L LF+                        
Sbjct: 238  TIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNGSVEAD 297

Query: 877  -FIFSILGMHLFGCK-------------FASERDGDTLPDR--------------KNFDS 908
              ++  L ++L   +               +  D  T P+                +FDS
Sbjct: 298  GLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDS 357

Query: 909  LLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
              WA + +F+++TQ+ W ++    + S      ++F+ ++  G++ L NL++A++   ++
Sbjct: 358  FAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYE 417

Query: 969  AEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEH 1028
             +                    +Q   A   E E  F       +  +K+  AL   G  
Sbjct: 418  EQ--------------------NQATIAETEEKEKRFQEAM---EMLKKEHEALTIRGVD 454

Query: 1029 PELRKSL-LPPLIIHTAATPMSLPKSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPP 1087
               R SL + PL       P++  +  S           R+  SSG+ E G     KS  
Sbjct: 455  TVSRSSLEMSPL------APVNSHERRS---------KRRKRMSSGTEECGEDRLPKS-- 497

Query: 1088 SARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSGERRSLLSGEGQESQDEEESSE 1147
                S   P         R  +  SL R  S     P   R S+ +   ++   E + ++
Sbjct: 498  ---DSEDGP---------RAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFAD 545

Query: 1148 EERASPAGSDHRHRG-----SLEREAKSSFDLPDTLQVPG--LHRTASGRGSASEHQDCN 1200
            +E ++   S+  H        L R +      P T   PG  LH      G  +   DCN
Sbjct: 546  DENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGT-SAPGHALH------GKKNSTVDCN 598

Query: 1201 G------------KSASGRLARALRPDDPPLDGDDADD--------------EGNLSKGE 1234
            G             S    L R +  + PP     +++              +G    G 
Sbjct: 599  GVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGA 658

Query: 1235 RVRAWIRARLPACCLERDSWSAYIFPP-----QSRFRLL------------CHRIITHKM 1277
            R RA     +    LE    S +  PP       R+ +                ++    
Sbjct: 659  RQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPF 718

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
             D  + + I LN + +A+E   +     E   L + N +FT +F AEMT K++AL   + 
Sbjct: 719  TDLTITMCIVLNTLFMALEHYNMTSEFEE--MLQVGNLVFTGIFTAEMTFKIIALDPYY- 775

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQG 1397
               Y +  WN+ D ++V++S++++ +S +S+        L VLR  R LR  ++      
Sbjct: 776  ---YFQQGWNIFDSIIVILSLMELGLSRMSN--------LSVLRSFRLLRVFKLAKSWPT 824

Query: 1398 LKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
            L  +++ + +S+  +GN+ ++      IF ++G+QLF   +   +  D+
Sbjct: 825  LNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRDSDS 873



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 77/319 (24%), Positives = 146/319 (45%), Gaps = 52/319 (16%)

Query: 704  DLRDPHS-------RRQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVN 756
            D++DP         RR      D   +    +WRL   T   IV+  +F   I+  IL++
Sbjct: 1159 DVKDPEDCFTEGCVRRCPCCAVDTTQAPGKVWWRLR-KTCYHIVEHSWFETFIIFMILLS 1217

Query: 757  TLSMGIE--YHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVI 814
            + ++  E  Y E+ + +   LE ++ +FT +F LEMLLK + YG   Y  N +   D +I
Sbjct: 1218 SGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI 1277

Query: 815  VVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFC 869
            V +S+  +V       + G +  LRT R +R L+ +     ++  +  L+  + ++    
Sbjct: 1278 VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVL 1337

Query: 870  MLLMLFIFIFSILGMHLFGCKFA---SERDGD-----TLPDRK----------------- 904
            ++ ++F  IFSI+G++LF  KF    ++ +GD     T+ + K                 
Sbjct: 1338 LVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGELYWTKV 1397

Query: 905  --NFDSLLWAIVTVFQILTQEDWNKVLY-----NGMASTSSWAA-----LYFIALMTFGN 952
              NFD++    + + Q+ T + W  ++Y      G      W       +YF+  + FG+
Sbjct: 1398 KVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGS 1457

Query: 953  YVLFNLLVAILVEGFQAEE 971
            +   NL + ++++ F  ++
Sbjct: 1458 FFTLNLFIGVIIDNFNQQK 1476



 Score = 90.9 bits (224), Expect = 9e-18
 Identities = 53/180 (29%), Positives = 88/180 (48%), Gaps = 17/180 (9%)

Query: 1257 YIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYI 1316
            Y+  P    R    +I+ H +F+ +++  I  NC+ +A   P       E        Y 
Sbjct: 112  YVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWTKYVE--------YT 163

Query: 1317 FTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376
            FTA++  E  VK++A G+C     +LR  WN LD  +++++     V          LG 
Sbjct: 164  FTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTTEFVD---------LGN 214

Query: 1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKG 1436
            +  LR  R LR L+ IS   GLK +V  L+ S+K + +++V+      +F ++G+QLF G
Sbjct: 215  VSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 274



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 69/269 (25%), Positives = 122/269 (45%), Gaps = 33/269 (12%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV  + F   IM  I +N ++M +E  +Q  E  N L   N++F ++F  E ++KL    
Sbjct: 1523 IVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR 1582

Query: 799  PFGYIKNPYNIFDGVIVVISVW-----EIVGQQGGGLSVLRTFRLMRV---LKLVRFLPA 850
             + Y  N +NIFD V+V++S+      +I+ +     ++ R  RL R+   L+L+R    
Sbjct: 1583 HY-YFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKG 1641

Query: 851  LQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLL 910
            ++  L  LM ++  +    +LL L +FI+SI GM      FA  +    + D  NF +  
Sbjct: 1642 IRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGM----ANFAYVKWEAGIDDMFNFQTFA 1697

Query: 911  WAIVTVFQILTQEDWNKVL--------------------YNGMASTSSWAALYFIALMTF 950
             +++ +FQI T   W+ +L                      G   + +   L+F   +  
Sbjct: 1698 NSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPAVGILFFTTYIII 1757

Query: 951  GNYVLFNLLVAILVEGFQAEEISKREDAS 979
               ++ N+ +AI++E F        E  S
Sbjct: 1758 SFLIVVNMYIAIILENFSVATEESTEPLS 1786



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 53/175 (30%), Positives = 93/175 (53%), Gaps = 9/175 (5%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERI-FLTLSNYIFTA 1319
            P ++++     I+T + FD  ++ +I LN +T+ +E    D  S E+I  L   N +F A
Sbjct: 1512 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVET---DDQSPEKINILAKINLLFVA 1568

Query: 1320 VFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRV 1379
            +F  E  VK+ AL        Y  +SWN+ D ++V++S++  ++S +         + RV
Sbjct: 1569 IFTGECIVKLAAL-----RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRV 1623

Query: 1380 LRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            +RL R  R LR+I  A+G++ ++  LM SL  + NI ++      I+ I G+  F
Sbjct: 1624 IRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1678



 Score = 62.8 bits (151), Expect = 3e-09
 Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 8/156 (5%)

Query: 78  VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
           V +P+ +    + I+LN     +F   E     S+   +LQ  +      F  EM  K++
Sbjct: 714 VMDPFTDLTITMCIVLNT----LFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKII 769

Query: 138 ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSM 197
           AL  +    Y    WN  D  IVI  ++E  L   + + S +R+ R+LR  +     P++
Sbjct: 770 ALDPY---YYFQQGWNIFDSIIVILSLMELGLSRMS-NLSVLRSFRLLRVFKLAKSWPTL 825

Query: 198 RILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             L+ ++ +++  LGN+ L+   + FIF +VG+QL+
Sbjct: 826 NTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLF 861



 Score = 61.6 bits (148), Expect = 6e-09
 Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 15/159 (9%)

Query: 83   FERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF 142
            F+   M +I LN VT+ +    E      ++  IL   +    A F  E +VK+ AL   
Sbjct: 1529 FDVTIMFLICLNMVTMMV----ETDDQSPEKINILAKINLLFVAIFTGECIVKLAAL--- 1581

Query: 143  GKKCYLGDTWNRLDFFIVIAGMLEYSLD--LQNVSFS-----AVRTVRVLRPLRAINRVP 195
             +  Y  ++WN  DF +VI  ++   L   +Q   FS      +R  R+ R LR I    
Sbjct: 1582 -RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAK 1640

Query: 196  SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             +R L+  L+ +LP L N+ LL F V FI+ I G+  +A
Sbjct: 1641 GIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFA 1679



 Score = 32.7 bits (73), Expect = 2.8
 Identities = 15/59 (25%), Positives = 37/59 (62%), Gaps = 2/59 (3%)

Query: 342 YAWIAIFQVITLEGWVDIMYFVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFS 399
           +A++ IF+++  E W++ M+  M+        + F+L++++G+  ++NL L ++ + FS
Sbjct: 886 HAFLIIFRILCGE-WIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFS 943


>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
            subunit [Homo sapiens]
          Length = 2339

 Score =  175 bits (443), Expect = 3e-43
 Identities = 144/525 (27%), Positives = 232/525 (44%), Gaps = 61/525 (11%)

Query: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
            R++V ++ F   ++  + +NTL + + ++ QP  LT  L  +  VF  LF  EM LK+  
Sbjct: 476  RRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYG 535

Query: 797  YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
             GP  Y ++ +N FD  ++V SV+E+V          G+SVLR  RL+R+ K+ ++  +L
Sbjct: 536  LGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSL 595

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
            +  +V L+ +M ++ +   LL LFI +F++LGM LFG +F  + +  T     NFD+   
Sbjct: 596  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPT----TNFDTFPA 651

Query: 912  AIVTVFQILTQEDWNKVLYNGM-----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEG 966
            AI+TVFQILT EDWN V+Y+G+      S   +++ YFI L  FGNY L N+ +AI V+ 
Sbjct: 652  AILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDN 711

Query: 967  F-QAEEISK----REDASGQ---------------LSCIQLPVDSQGGDANKSESEPDFF 1006
               A+E++K     E+A+ Q               +S   + + ++  ++ K+ S  +  
Sbjct: 712  LANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKARSVWEQR 771

Query: 1007 SPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLPKSTSTGLGEALGPAS 1066
            +  L     R  C AL S  +  E  +      +     T +  P     G   A GP  
Sbjct: 772  ASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPVG 831

Query: 1067 RRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLKRRSPSG 1126
             +     +  P      +     R    +P   A+    R  +  +    P  +   P  
Sbjct: 832  GKARPEAAEAPEGVDPPRRHHRHRDKDKTP---AAGDQDRAEAPKAESGEPGAREERPRP 888

Query: 1127 ERRSLLSGEGQESQDEEESSEEERASP---AGSDHRHRGSLEREAKSSFDLPDTLQVPGL 1183
             R        +E+    E+  E    P    G  H  RGS E  A+         + P  
Sbjct: 889  HR-----SHSKEAAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAE---------REPRR 934

Query: 1184 HRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEG 1228
            HR       A  HQD + + A  +  R  R    P  G    + G
Sbjct: 935  HR-------AHRHQDPSKECAGAKGERRARHRGGPRAGPREAESG 972



 Score =  158 bits (400), Expect = 3e-38
 Identities = 130/491 (26%), Positives = 207/491 (42%), Gaps = 106/491 (21%)

Query: 27  GAGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVF----------------FYLSQDSRP 70
           GAGG  GPG     PG      + +   A    ++                F  S+D+  
Sbjct: 25  GAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVV 84

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDD---FIFAF 127
           R +  R    P FE + +  I+ NC+ L +    E    D  +  + +  DD   +    
Sbjct: 85  RKYAKRITEWPPFEYMILATIIANCIVLAL----EQHLPDGDKTPMSERLDDTEPYFIGI 140

Query: 128 FAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLR 186
           F  E  +K++ALG +F K  YL + WN +DF +V+ G+L  +    +     +R VRVLR
Sbjct: 141 FCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGT--DFDLRTLRAVRVLR 198

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPEN 246
           PL+ ++ +PS+++++  ++  +  L  + LL FF   +F I+G++ + G     CF    
Sbjct: 199 PLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF---- 254

Query: 247 FSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYN 306
              P S D E                                     G  PCG +  A  
Sbjct: 255 ---PNSTDAEPV-----------------------------------GDFPCGKEAPARL 276

Query: 307 SSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMD- 365
              +T C    +Y+         P  G  NFDNI +A + +FQ IT+EGW DI+Y   D 
Sbjct: 277 CEGDTEC---REYWP-------GPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDA 326

Query: 366 AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLAS 425
           A + +N++YFI LII+GSFFM+NL L V++ +F++ ++R            + N      
Sbjct: 327 AGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER------------VENRRAFLK 374

Query: 426 FSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRS 485
                    EL  YL +I +     LA+  R A               +E  P     R+
Sbjct: 375 LRRQQQIERELNGYLEWIFKAEEVMLAEEDRNA---------------EEKSPLDVLKRA 419

Query: 486 HRRLSVHHLVH 496
             + S + L+H
Sbjct: 420 ATKKSRNDLIH 430



 Score =  139 bits (349), Expect = 3e-32
 Identities = 129/467 (27%), Positives = 199/467 (42%), Gaps = 59/467 (12%)

Query: 1051 PKSTSTGLGEALGP-ASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSS 1109
            P    +  G   GP   RR    GS E  A  E +   + R    S   A +    R   
Sbjct: 899  PPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARH 958

Query: 1110 RNSLGRAPSLKRRSPSGE---RRSLLSGEGQ--------ESQDEEESSEEERASPAGSDH 1158
            R      P   R + SGE   RR     + Q        E+ ++E + +E     A  + 
Sbjct: 959  RGGPRAGP---REAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEK 1015

Query: 1159 RHRGSLEREAKSSFDLPDTLQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDP- 1217
              R    RE     +   T+ V  +H   S      E Q  +  +         +P DP 
Sbjct: 1016 ELRNHQPREPHCDLETSGTVTVGPMHTLPSTCLQKVEEQPEDADNQRNVTRMGSQPPDPN 1075

Query: 1218 -----------PLDGDDADDEGNL-----SKGER-------VRAWIRARLPACCLERDSW 1254
                       PL        GN+     ++G++       +R+  R  +P         
Sbjct: 1076 TIVHIPVMLTGPLGEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYS------- 1128

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
            S +   P +  R  CH I+T + F+ V+LV+I L+ I +A E P +   S     L   +
Sbjct: 1129 SMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP-VRTDSPRNNALKYLD 1187

Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
            YIFT VF  EM +K++ LG      AY R  WN+LD ++V  +++    S    S  K +
Sbjct: 1188 YIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFS---GSKGKDI 1244

Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
              ++ LR+LR LRPL+ I R   LK V + +++SLK + NI+++   F  IF ++ VQLF
Sbjct: 1245 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLF 1304

Query: 1435 KGKFFVCQGE------DTRN--ITNKSDCAEASYR-WVRHKYNFDNL 1472
            KGKFF C  E      D R   +  + +  EA  R W ++ +++DN+
Sbjct: 1305 KGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNV 1351



 Score =  114 bits (286), Expect = 6e-25
 Identities = 69/239 (28%), Positives = 133/239 (55%), Gaps = 22/239 (9%)

Query: 749  IMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYN 808
            IM  I +NT+ + +++++ P E    L+  NIVFTS+F++E +LK++ +G   Y ++ +N
Sbjct: 1477 IMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWN 1536

Query: 809  IFDGVIVVISVWEIVGQQGG------GLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTM 862
            +FD V V+ S+ +I+  +         LS LR FR  R++KL+R    ++  L   +++ 
Sbjct: 1537 VFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSF 1596

Query: 863  DNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDR-KNFDSLLWAIVTVFQILT 921
              +   C+L+ +  FI++I+GM +FG       D DT  +R  NF + L A++ +F+  T
Sbjct: 1597 KALPYVCLLIAMLFFIYAIIGMQVFG---NIALDDDTSINRHNNFRTFLQALMLLFRSAT 1653

Query: 922  QEDWNKVLY------------NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
             E W++++             N     S +A  YF++ +   ++++ NL VA++++ F+
Sbjct: 1654 GEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFE 1712



 Score =  104 bits (259), Expect = 8e-22
 Identities = 95/405 (23%), Positives = 164/405 (40%), Gaps = 87/405 (21%)

Query: 44   ADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRP 103
            AD      P P +     F LS  +  R +C   V   +FE + ++VI L+ + L    P
Sbjct: 1113 ADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVVILVVIALSSIALAAEDP 1172

Query: 104  CEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIA 162
               +  DS R   L+  D      F  EMV+KM+ LG+      Y  D WN LDF +V  
Sbjct: 1173 ---VRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSG 1229

Query: 163  GMLEYSL------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLL 216
             ++ ++       D+  +   ++R +RVLRPL+ I R+P ++ +   ++++L  + N+L+
Sbjct: 1230 ALVAFAFSGSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILI 1287

Query: 217  LCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRE 276
            +     FIF ++ VQL+ G                                 F C+   +
Sbjct: 1288 VYMLFMFIFAVIAVQLFKGKF-------------------------------FYCTDESK 1316

Query: 277  NGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAIN 336
               R CR                LDYE     +      W +Y                +
Sbjct: 1317 ELERDCRGQ-------------YLDYEKEEVEAQPR--QWKKY--------------DFH 1347

Query: 337  FDNIGYAWIAIFQVITLEGWVDIMYFVMDA----------HSFYNFIYFILLIIVGSFFM 386
            +DN+ +A + +F V T EGW  ++   +DA          +     I++++  +V  FF 
Sbjct: 1348 YDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFF 1407

Query: 387  INLCLVVIATQFSETKQR---ESQLMREQR--VRFLSNASTLASF 426
            +N+ + +I   F E   +   E  L + +R  + F  +A  L  +
Sbjct: 1408 VNIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRY 1452



 Score =  102 bits (254), Expect = 3e-21
 Identities = 76/275 (27%), Positives = 129/275 (46%), Gaps = 42/275 (15%)

Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
           ++I +   F   I+  I+ N + + +E H    + T     L+ +   F  +F  E  +K
Sbjct: 89  KRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIK 148

Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
           ++  G       Y++N +N+ D V+V+  +    G     L  LR  R++R LKLV  +P
Sbjct: 149 IIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFD-LRTLRAVRVLRPLKLVSGIP 207

Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCK-----FASERDGDTLPD-- 902
           +LQ  L  +MK M  +    +LL   I +F+I+G+  +  K     F +  D + + D  
Sbjct: 208 SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFP 267

Query: 903 --------------------------RKNFDSLLWAIVTVFQILTQEDWNKVLYN-GMAS 935
                                       NFD++L+AI+TVFQ +T E W  +LYN   A+
Sbjct: 268 CGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAA 327

Query: 936 TSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
            ++W  LYFI L+  G++ + NL++ +L   F  E
Sbjct: 328 GNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 362



 Score = 97.4 bits (241), Expect = 9e-20
 Identities = 141/629 (22%), Positives = 243/629 (38%), Gaps = 115/629 (18%)

Query: 424  ASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCS 483
            A   EPG+  E    +  +    A    A+  R  G        P P GG+      S  
Sbjct: 874  AESGEPGAREERPRPHRSHSKEAAGPPEARSERGRG--------PGPEGGRRHHRRGSPE 925

Query: 484  RSHRRLSVHHLVHHHHHHHHHYHLGNGTLRA-----PRASPEIQDRDANGSRRLMLPPPS 538
             +  R    H  H H           G  RA     PRA P   +     +RR      +
Sbjct: 926  EAAEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPRAGPREAESGEEPARRHRARHKA 985

Query: 539  TPALSGAPPG-----GAESVHSFYHADCHLEPVRCQAPPPRSPSEASGR-TVGSGKVYPT 592
             PA              E       AD   E    Q   P    E SG  TVG       
Sbjct: 986  QPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREPHCDLETSGTVTVGP------ 1039

Query: 593  VHTSPPPETLKEKALVEVAASSGPPTLTSLNI-PPGPYSSMHKLLETQSTGACQSSCKIS 651
            +HT P   T  +K   +   +     +T +   PP P + +H  +    TG    +  + 
Sbjct: 1040 MHTLP--STCLQKVEEQPEDADNQRNVTRMGSQPPDPNTIVH--IPVMLTGPLGEATVVP 1095

Query: 652  SPCLKADSGACGPDSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSR 711
            S  +  +S A            G  EVE AD  M       V              P+S 
Sbjct: 1096 SGNVDLESQA-----------EGKKEVE-ADDVMRSGPRPIV--------------PYSS 1129

Query: 712  RQRSLGPDAEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE- 770
                      P+++L   R  C     IV  +YF   I++ I ++++++  E   + +  
Sbjct: 1130 MFC-----LSPTNLL---RRFC---HYIVTMRYFEVVILVVIALSSIALAAEDPVRTDSP 1178

Query: 771  LTNALEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGVIV--VISVWEIVG 824
              NAL+  + +FT +F  EM++K++  G    P  Y ++ +NI D ++V   +  +   G
Sbjct: 1179 RNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG 1238

Query: 825  QQGGGLSVLRTFRLMRVL---KLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSI 881
             +G  ++ +++ R++RVL   K ++ LP L+     ++ ++ NV    ++ MLF+FIF++
Sbjct: 1239 SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAV 1298

Query: 882  LGMHLFGCKF--------ASERD--GDTLPDRK---------------NFDSLLWAIVTV 916
            + + LF  KF          ERD  G  L   K               ++D++LWA++T+
Sbjct: 1299 IAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTL 1358

Query: 917  FQILTQEDWNKVLYNGMAST----------SSWAALYFIALMTFGNYVLFNLLVAILVEG 966
            F + T E W  VL + + +T              +++++       +   N+ VA+++  
Sbjct: 1359 FTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIIT 1418

Query: 967  FQAEEISKREDAS---GQLSCIQLPVDSQ 992
            FQ +      + S    + +CI   + ++
Sbjct: 1419 FQEQGDKVMSECSLEKNERACIDFAISAK 1447



 Score = 95.5 bits (236), Expect = 4e-19
 Identities = 57/187 (30%), Positives = 106/187 (56%), Gaps = 14/187 (7%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
            S ++F   +  R    RI     F++++L  I  NCI +A+E+   D      +ER+  T
Sbjct: 74   SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDT 133

Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
               +I   +F  E  +K++ALG+ F + +YLR+ WNV+D ++VL  ++       + +GT
Sbjct: 134  EPYFI--GIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGIL-------ATAGT 184

Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
                 LR LR +R LRPL+++S    L++V++++M ++ P+  I ++     ++F I+G+
Sbjct: 185  DF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGL 242

Query: 1432 QLFKGKF 1438
            + + GKF
Sbjct: 243  EFYMGKF 249



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 55/186 (29%), Positives = 105/186 (56%), Gaps = 13/186 (6%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTL-- 1312
            S+Y    +  FR    R++  + F  VVL ++ LN + +AM    +  +   R+  TL  
Sbjct: 461  SSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAM----VHYNQPRRLTTTLYF 516

Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
            + ++F  +FL EM++K+  LG     ++Y RSS+N  D  +++ SV +++ + +    + 
Sbjct: 517  AEFVFLGLFLTEMSLKMYGLG----PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSF 572

Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
             + +LR LRLLR  +  +  S    L+ +V +L++S+K I +++ +   F ++F +LG+Q
Sbjct: 573  GISVLRALRLLRIFKVTKYWS---SLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQ 629

Query: 1433 LFKGKF 1438
            LF G+F
Sbjct: 630  LFGGQF 635



 Score = 84.0 bits (206), Expect = 1e-15
 Identities = 61/216 (28%), Positives = 109/216 (50%), Gaps = 19/216 (8%)

Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
            GD    E +L K ER  A I   + A  L R       + PQ+R  F+      +    F
Sbjct: 1423 GDKVMSECSLEKNER--ACIDFAISAKPLTR-------YMPQNRQSFQYKTWTFVVSPPF 1473

Query: 1279 DHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGE 1338
            ++ ++ +I LN + + M+    D      + L   N +FT++F  E  +K++A    FG 
Sbjct: 1474 EYFIMAMIALNTVVLMMKF--YDAPYEYELMLKCLNIVFTSMFSMECVLKIIA----FGV 1527

Query: 1339 QAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGL 1398
              Y R +WNV D + VL S+ DILV+ ++++   I   L  LRL R  R ++++ +   +
Sbjct: 1528 LNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFI--NLSFLRLFRAARLIKLLRQGYTI 1585

Query: 1399 KLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
            ++++ T + S K +  + ++    F I+ I+G+Q+F
Sbjct: 1586 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1621



 Score = 58.9 bits (141), Expect = 4e-08
 Identities = 45/176 (25%), Positives = 86/176 (48%), Gaps = 14/176 (7%)

Query: 66   QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
            Q  + ++W    V +P FE   M +I LN V L M    +      +   +L+  +    
Sbjct: 1458 QSFQYKTWTF--VVSPPFEYFIMAMIALNTVVLMM----KFYDAPYEYELMLKCLNIVFT 1511

Query: 126  AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQN-VSFSAVR 180
            + F++E V+K++A G+     Y  D WN  DF  V+  + +  +    +  N ++ S +R
Sbjct: 1512 SMFSMECVLKIIAFGVLN---YFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLR 1568

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
              R  R ++ + +  ++RIL+   + +   L  V LL   +FFI+ I+G+Q++  +
Sbjct: 1569 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1624



 Score = 54.3 bits (129), Expect = 9e-07
 Identities = 45/179 (25%), Positives = 85/179 (47%), Gaps = 13/179 (7%)

Query: 62  FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFD 121
           ++  ++   R +  R V    F  + + V+ LN + + M    +      +R      F 
Sbjct: 463 YFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQP-----RRLTTTLYFA 517

Query: 122 DFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF-- 176
           +F+F   F  EM +KM  LG    + Y   ++N  DF +++  + E  ++      SF  
Sbjct: 518 EFVFLGLFLTEMSLKMYGLG---PRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGI 574

Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
           S +R +R+LR  +      S+R LV  LL+++  + ++L L F    +F ++G+QL+ G
Sbjct: 575 SVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGG 633



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 18/73 (24%), Positives = 39/73 (53%), Gaps = 5/73 (6%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
           NFD    A + +FQ++T E W  +MY  +++        ++  YFI+L + G++ ++N+ 
Sbjct: 645 NFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVF 704

Query: 391 LVVIATQFSETKQ 403
           L +     +  ++
Sbjct: 705 LAIAVDNLANAQE 717



 Score = 34.3 bits (77), Expect = 0.96
 Identities = 26/104 (25%), Positives = 44/104 (42%), Gaps = 13/104 (12%)

Query: 318  QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM------------D 365
            Q + N +  +        NF     A + +F+  T E W +IM   +            +
Sbjct: 1619 QVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQANATE 1678

Query: 366  AHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
              S + + YF+  I + SF M+NL + VI   F E   R+S ++
Sbjct: 1679 CGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1721


>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
           subunit [Homo sapiens]
          Length = 2270

 Score =  175 bits (443), Expect = 3e-43
 Identities = 115/319 (36%), Positives = 178/319 (55%), Gaps = 19/319 (5%)

Query: 673 AGAGEVELADRE-MPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFW-- 729
           AG   +E+  R  +  S +EA+   + D    D+    +   R+    A+   V  F   
Sbjct: 402 AGTSALEVLRRATIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHK 461

Query: 730 -RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFAL 788
            RL+  + R +V S+ F   ++  + +NT  + I +H QP+ LT+ L  +  +F  LF L
Sbjct: 462 ERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLL 521

Query: 789 EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLK 843
           EM LK+   GP  Y  + +N FD  + V S++E+V          G+SVLR  RL+R+ K
Sbjct: 522 EMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFK 581

Query: 844 LVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDR 903
           + ++  +L+  +V LM +M ++ +   LL LFI +F++LGM LFG +F +  DG      
Sbjct: 582 ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRF-NFNDG---TPS 637

Query: 904 KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-----ASTSSWAALYFIALMTFGNYVLFNL 958
            NFD+   AI+TVFQILT EDWN+V+YNG+      S+  W+A+YFI L  FGNY L N+
Sbjct: 638 ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNV 697

Query: 959 LVAILVEGF-QAEEISKRE 976
            +AI V+    A+E++K E
Sbjct: 698 FLAIAVDNLANAQELTKDE 716



 Score =  145 bits (367), Expect = 2e-34
 Identities = 106/365 (29%), Positives = 180/365 (49%), Gaps = 70/365 (19%)

Query: 62  FYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQA 119
           F   +D+  R +  + +  P FE + +  I+ NC+ L + +  P +D    S+R   L+ 
Sbjct: 70  FIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRR---LEK 126

Query: 120 FDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQN--VSF 176
            + +    F  E  +K+VALG IF K  YL + WN +DF +V++G+L  +    N  V  
Sbjct: 127 TEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDL 186

Query: 177 SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
             +R VRVLRPL+ ++ +PS++I++  ++  +  L  + LL FF   +F I+G++ ++G 
Sbjct: 187 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 246

Query: 237 LRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGP 296
           L   CF+  +  L              E   P     P   G++ C              
Sbjct: 247 LHRACFMNNSGIL--------------EGFDP-----PHPCGVQGC-------------- 273

Query: 297 PCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGW 356
           P G +           C +W             P  G   FDNI +A + +FQ IT+EGW
Sbjct: 274 PAGYE-----------CKDW-----------IGPNDGITQFDNILFAVLTVFQCITMEGW 311

Query: 357 VDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLM 409
             ++Y   DA  + +N++YFI LII+GSFF++NL L V++ +F++ ++R        +L 
Sbjct: 312 TTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLR 371

Query: 410 REQRV 414
           R+Q++
Sbjct: 372 RQQQI 376



 Score =  127 bits (320), Expect = 6e-29
 Identities = 72/228 (31%), Positives = 128/228 (56%), Gaps = 11/228 (4%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
            S +IF   +  R  CH I+  + F+  +L++I  + I +A E P +      ++ L   +
Sbjct: 1132 SMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKV-LRYFD 1190

Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI-LVSMVSDSGTKI 1373
            Y+FT VF  EM +K++  G    + +Y R  WN+LD ++V+ +++   L + +  +  + 
Sbjct: 1191 YVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRD 1250

Query: 1374 LGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQL 1433
            +  ++ LR+LR LRPL+ I R   LK V + +++SLK + NI+++   F  IF ++ VQL
Sbjct: 1251 IKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQL 1310

Query: 1434 FKGKFFVC--QGEDTRN------ITNKSDCAEASYR-WVRHKYNFDNL 1472
            FKGKFF C    +DT        + ++ +  E   R W RH++++DN+
Sbjct: 1311 FKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHEFHYDNI 1358



 Score =  107 bits (267), Expect = 9e-23
 Identities = 68/255 (26%), Positives = 130/255 (50%), Gaps = 28/255 (10%)

Query: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
            V S  F   IM  I +NT+ + ++Y+  P     AL+  NI FT +F+LE +LK++ +G 
Sbjct: 1475 VVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGF 1534

Query: 800  FGYIKNPYNIFDGVIVVISVWEI-------VGQQGGGLSVLRTFRLMRVLKLVRFLPALQ 852
              Y ++ +NIFD + V+ S+ EI       V   G  +S L+ FR  R++KL+R    ++
Sbjct: 1535 LNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIR 1594

Query: 853  RQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWA 912
              L   +++   +   C+L+ +  FI++I+GM +FG     E     +    NF S   +
Sbjct: 1595 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEE--SHINRHNNFRSFFGS 1652

Query: 913  IVTVFQILTQEDWNKVLYNGMAST-------------------SSWAALYFIALMTFGNY 953
            ++ +F+  T E W +++ + +                      +  A +YF++ + F ++
Sbjct: 1653 LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSF 1712

Query: 954  VLFNLLVAILVEGFQ 968
            ++ NL VA++++ F+
Sbjct: 1713 LMLNLFVAVIMDNFE 1727



 Score =  102 bits (253), Expect = 4e-21
 Identities = 78/280 (27%), Positives = 128/280 (45%), Gaps = 51/280 (18%)

Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
           +K++D   F   I+  I+ N + + +E H   ++ T     LE +   F  +F  E  +K
Sbjct: 83  KKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIK 142

Query: 794 LLVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQQGG---GLSVLRTFRLMRVLKLVR 846
           ++  G       Y++N +N+ D ++V+  +    G        L  LR  R++R LKLV 
Sbjct: 143 IVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVS 202

Query: 847 FLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF------------------- 887
            +P+LQ  L  +MK M  +    +LL   I +F+I+G+  +                   
Sbjct: 203 GIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGF 262

Query: 888 ---------GCKFASE-------RDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYN 931
                    GC    E        DG T      FD++L+A++TVFQ +T E W  VLYN
Sbjct: 263 DPPHPCGVQGCPAGYECKDWIGPNDGIT-----QFDNILFAVLTVFQCITMEGWTTVLYN 317

Query: 932 -GMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
              A  ++W  LYFI L+  G++ + NL++ +L   F  E
Sbjct: 318 TNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKE 357



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 58/185 (31%), Positives = 104/185 (56%), Gaps = 8/185 (4%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMER--PKIDPHSAERIFLTL 1312
            S +IF   +  R    ++I    F++++L  I  NCI +A+E+  P+ D     R     
Sbjct: 68   SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKT 127

Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
              Y F  +F  E  +K+VALG+ F + +YLR+ WNV+D ++VL     IL +  +   T 
Sbjct: 128  EPY-FIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSG---ILATAGTHFNTH 183

Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
            +   LR LR +R LRPL+++S    L++V++++M ++ P+  I ++     ++F I+G++
Sbjct: 184  V--DLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLE 241

Query: 1433 LFKGK 1437
             + GK
Sbjct: 242  FYSGK 246



 Score = 87.4 bits (215), Expect = 1e-16
 Identities = 71/306 (23%), Positives = 141/306 (46%), Gaps = 52/306 (16%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPE-ELTNALEISNIVFTSLFALEMLLKLLVY 797
            IV+ +YF   I++ I  +++++  E       E    L   + VFT +F  EM++K++  
Sbjct: 1149 IVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQ 1208

Query: 798  GPF----GYIKNPYNIFDGVIVV-----ISVWEIVGQQGGG----LSVLRTFRLMRVLKL 844
            G       Y ++ +NI D V+VV      ++   +G   G     +  LR  R++R LK 
Sbjct: 1209 GLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKT 1268

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF----ASERD---- 896
            ++ LP L+     ++ ++ NV    ++  LF+FIF+++ + LF  KF     S +D    
Sbjct: 1269 IKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKE 1328

Query: 897  --GDTLPDRKN---------------FDSLLWAIVTVFQILTQEDWNKVLYNGM------ 933
              G+ +   KN               +D+++WA++T+F + T E W +VL + +      
Sbjct: 1329 CIGNYVDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEED 1388

Query: 934  ----ASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQ 986
                 S     +++++       +   N+ VA+++  FQ +     E+ S    + +CI 
Sbjct: 1389 RGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACID 1448

Query: 987  LPVDSQ 992
              + ++
Sbjct: 1449 FAISAK 1454



 Score = 85.9 bits (211), Expect = 3e-16
 Identities = 56/193 (29%), Positives = 99/193 (51%), Gaps = 17/193 (8%)

Query: 55   ALAPVVFFYLSQDSRP-RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQR 113
            A+ P    ++   + P R  C   V   +FE   +LVI  + + L    P   +  +S+R
Sbjct: 1126 AMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDP---VLTNSER 1182

Query: 114  CRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSL--- 169
             ++L+ FD      F  EMV+KM+  G I     Y  D WN LDF +V+  ++ ++L   
Sbjct: 1183 NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANA 1242

Query: 170  -------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVF 222
                   D++ +   ++R +RVLRPL+ I R+P ++ +   ++ +L  + N+L++     
Sbjct: 1243 LGTNKGRDIKTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFM 1300

Query: 223  FIFGIVGVQLWAG 235
            FIF ++ VQL+ G
Sbjct: 1301 FIFAVIAVQLFKG 1313



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 59/219 (26%), Positives = 110/219 (50%), Gaps = 24/219 (10%)

Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
            GD   +E +L K ER  A I   + A  L R       + PQ+R  F+      +    F
Sbjct: 1430 GDKMMEECSLEKNER--ACIDFAISAKPLTR-------YMPQNRHTFQYRVWHFVVSPSF 1480

Query: 1279 DHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGE 1338
            ++ ++ +I LN + + M+     P + E + L   N  FT VF  E  +KV+A    FG 
Sbjct: 1481 EYTIMAMIALNTVVLMMKYYSA-PCTYE-LALKYLNIAFTMVFSLECVLKVIA----FGF 1534

Query: 1339 QAYLRSSWNVLDGLLVLISVIDILVS---MVSDSGTKILGMLRVLRLLRTLRPLRVISRA 1395
              Y R +WN+ D + V+ S+ +I+++   +V+ SG      +  L+L R  R ++++ + 
Sbjct: 1535 LNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFN----MSFLKLFRAARLIKLLRQG 1590

Query: 1396 QGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
              +++++ T + S K +  + ++    F I+ I+G+Q+F
Sbjct: 1591 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF 1629



 Score = 72.0 bits (175), Expect = 4e-12
 Identities = 50/196 (25%), Positives = 101/196 (51%), Gaps = 15/196 (7%)

Query: 1256 AYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAM---ERPKIDPHSAERIFLTL 1312
            +Y    +   R+    ++  ++F  +VL ++ LN   +A+    +P+   H      L  
Sbjct: 456  SYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQPQWLTH-----LLYY 510

Query: 1313 SNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTK 1372
            + ++F  +FL EM++K+  +G     + Y  SS+N  D  + + S+ +++ ++     + 
Sbjct: 511  AEFLFLGLFLLEMSLKMYGMG----PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSF 566

Query: 1373 ILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQ 1432
             + +LR LRLLR  +   +      L+ +V +LMSS+K I +++ +   F ++F +LG+Q
Sbjct: 567  GISVLRALRLLRIFK---ITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQ 623

Query: 1433 LFKGKFFVCQGEDTRN 1448
            LF G+F    G  + N
Sbjct: 624  LFGGRFNFNDGTPSAN 639



 Score = 60.8 bits (146), Expect = 1e-08
 Identities = 52/168 (30%), Positives = 78/168 (46%), Gaps = 19/168 (11%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAF---FAVEMVV 134
            V +P FE   M +I LN V L M          S  C    A      AF   F++E V+
Sbjct: 1475 VVSPSFEYTIMAMIALNTVVLMM-------KYYSAPCTYELALKYLNIAFTMVFSLECVL 1527

Query: 135  KMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSLD---LQNVS---FSAVRTVRVLRPL 188
            K++A G      Y  DTWN  DF  VI  + E  L    L N S    S ++  R  R +
Sbjct: 1528 KVIAFGFLN---YFRDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLI 1584

Query: 189  RAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
            + + +  ++RIL+   + +   L  V LL   +FFI+ I+G+Q++  +
Sbjct: 1585 KLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1632



 Score = 51.2 bits (121), Expect = 8e-06
 Identities = 33/121 (27%), Positives = 64/121 (52%), Gaps = 8/121 (6%)

Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
           + +F+F   F +EM +KM  +G    + Y   ++N  DF + +  + E  +++     SF
Sbjct: 510 YAEFLFLGLFLLEMSLKMYGMG---PRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSF 566

Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             S +R +R+LR  +      S+R LV  L+ ++  + ++L L F    +F ++G+QL+ 
Sbjct: 567 GISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFG 626

Query: 235 G 235
           G
Sbjct: 627 G 627



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 26/105 (24%), Positives = 53/105 (50%), Gaps = 13/105 (12%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
           NFD    A + +FQ++T E W ++MY  + +        ++ IYFI+L + G++ ++N+ 
Sbjct: 639 NFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLLNVF 698

Query: 391 LVVI------ATQFSETKQRESQLMREQRVRFLSNASTLASFSEP 429
           L +       A + ++ +Q E +   ++    L  A  ++  S P
Sbjct: 699 LAIAVDNLANAQELTKDEQEEEEAFNQKHA--LQKAKEVSPMSAP 741



 Score = 37.7 bits (86), Expect = 0.087
 Identities = 25/106 (23%), Positives = 50/106 (47%), Gaps = 15/106 (14%)

Query: 336  NFDNIGYAWIAIFQVITLEGWVDIMYFVMD----------AHSFYNFIYFILLIIVGSFF 385
            ++DNI +A + +F V T EGW  ++   +D          ++     I++++  +V  FF
Sbjct: 1354 HYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFF 1413

Query: 386  MINLCLVVIATQFSETKQR---ESQLMREQR--VRFLSNASTLASF 426
             +N+ + +I   F E   +   E  L + +R  + F  +A  L  +
Sbjct: 1414 FVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRY 1459


>gi|53832007 calcium channel, voltage-dependent, L type, alpha 1F
           subunit [Homo sapiens]
          Length = 1977

 Score =  165 bits (418), Expect = 3e-40
 Identities = 100/269 (37%), Positives = 153/269 (56%), Gaps = 15/269 (5%)

Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
           R+ V S      +++ + +NTL++  E+H QP  LT   E +N V   LF +EMLLKL  
Sbjct: 523 RRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQEYANKVLLCLFTVEMLLKLYG 582

Query: 797 YGPFGYIKNPYNIFD-----GVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLPAL 851
            GP  Y+ + +N FD     G I+  ++ E+   Q  G+SVLR  RL+R+ K+ R   +L
Sbjct: 583 LGPSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASL 642

Query: 852 QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
              +  L+ +M ++A+  +LL LFI IFS+LGM LFG KF  ++   T   R  FD+   
Sbjct: 643 SNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQ---THTKRSTFDTFPQ 699

Query: 912 AIVTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNLLVAILVE 965
           A++TVFQILT EDWN V+Y+G+ +            +YFI L   GNY+L N+ +AI V+
Sbjct: 700 ALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLAIAVD 759

Query: 966 GFQAEEISKREDASGQLSCIQ-LPVDSQG 993
              + +    +D  G+ S  + LP +++G
Sbjct: 760 NLASGDAGTAKDKGGEKSNEKDLPQENEG 788



 Score =  152 bits (384), Expect = 2e-36
 Identities = 116/413 (28%), Positives = 186/413 (45%), Gaps = 81/413 (19%)

Query: 28  AGGRPGPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERIS 87
           + G  G G+ ++    +  +   +     +P   F L+  +  R  C+  V    F+ + 
Sbjct: 39  SSGASGLGTPKRRNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILI 98

Query: 88  MLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVEMVVKMVALG-IFGKK 145
           +L I  NCV LG++ P  +   ++    + Q   +++F   F VE V+K+VA G +    
Sbjct: 99  LLTIFANCVALGVYIPFPEDDSNTANHNLEQV--EYVFLVIFTVETVLKIVAYGLVLHPS 156

Query: 146 CYLGDTWNRLDFFIVIAGMLEYSLDLQ---------------NVSFSAVRTVRVLRPLRA 190
            Y+ + WN LDF IV+ G+    L+                      A+R  RVLRPLR 
Sbjct: 157 AYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRL 216

Query: 191 INRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLP 250
           ++ VPS+ I++  ++  L  L ++ LL  FV  I+ I+G++L+ G +   C+        
Sbjct: 217 VSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYF------- 269

Query: 251 LSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSN 310
           L  D+E       ED SP             C S        G G  C L+         
Sbjct: 270 LGSDME-----AEEDPSP-------------CAS-------SGSGRACTLN--------- 295

Query: 311 TTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF- 369
                     T C      P  G  NFDN  +A + +FQ +T+EGW D++Y++ DA  + 
Sbjct: 296 ---------QTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYE 346

Query: 370 YNFIYFILLIIVGSFFMINLCLVVIATQFSE-----------TKQRESQLMRE 411
             ++YF+ L+I GSFF++NL L V++ +FS+            KQRE Q M E
Sbjct: 347 LPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEE 399



 Score =  127 bits (319), Expect = 8e-29
 Identities = 73/216 (33%), Positives = 120/216 (55%), Gaps = 19/216 (8%)

Query: 1269 CHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVK 1328
            CH +I H +F +++LV I L+ +++A E P I  HS     L   +Y FT++F  E+ +K
Sbjct: 864  CHTLIHHHVFTNLILVFIILSSVSLAAEDP-IRAHSFRNHILGYFDYAFTSIFTVEILLK 922

Query: 1329 VVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRP 1388
            +   G      ++ RS +N+LD L+V +S+I   +       +  + ++++LR+LR LRP
Sbjct: 923  MTVFGAFLHRGSFCRSWFNMLDLLVVSVSLISFGIH------SSAISVVKILRVLRVLRP 976

Query: 1389 LRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
            LR I+RA+GLK VV+ +  +++ IGNI+++      +F  +GVQLFKGKF+ C  E    
Sbjct: 977  LRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHT 1036

Query: 1449 ---------ITNKSDCAEASYR---WVRHKYNFDNL 1472
                     +    D +    R   WV   +NFDN+
Sbjct: 1037 PQECKGSFLVYPDGDVSRPLVRERLWVNSDFNFDNV 1072



 Score =  120 bits (302), Expect = 8e-27
 Identities = 116/436 (26%), Positives = 192/436 (44%), Gaps = 81/436 (18%)

Query: 706  RDPHSRRQRSLGPDAEPSSVLAFWRLICDTFRK----IVDSKYFGRGIMIAILVNTLSMG 761
            R+ HS+ +      A+ S    F   + +  R+    IV+ K F   I++ I  N +++G
Sbjct: 51   RNQHSKHKTVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALG 110

Query: 762  IEYHEQPEELTNA----LEISNIVFTSLFALEMLLKLLVYG----PFGYIKNPYNIFDGV 813
            + Y   PE+ +N     LE    VF  +F +E +LK++ YG    P  YI+N +N+ D +
Sbjct: 111  V-YIPFPEDDSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFI 169

Query: 814  IVVISVWEIVGQQGGG----------------LSVLRTFRLMRVLKLVRFLPALQRQLVV 857
            IVV+ ++ ++ +QG G                +  LR FR++R L+LV  +P+L   L  
Sbjct: 170  IVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNS 229

Query: 858  LMKTMDNVATFCMLLMLFIFIFSILGMHLF------GCKFAS---ERDGDTLPDRK---- 904
            +MK +  +    +L++  I I++I+G+ LF       C F     E + D  P       
Sbjct: 230  IMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASSGSG 289

Query: 905  ----------------------NFDSLLWAIVTVFQILTQEDWNKVLY---NGMASTSSW 939
                                  NFD+  +A++TVFQ +T E W  VLY   + M     W
Sbjct: 290  RACTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPW 349

Query: 940  AALYFIALMTFGNYVLFNLLVAILVEGF--QAEEISKREDASGQLSCIQLPVDSQGG-DA 996
              +YF++L+ FG++ + NL++ +L   F  + E+   R D   Q    Q+  D +G  D 
Sbjct: 350  --VYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKQREKQQMEEDLRGYLDW 407

Query: 997  NKSESEPDFFSPSLD---------GDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATP 1047
                 E D   PS D         G    +  LA ++      LR         H+ ++ 
Sbjct: 408  ITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLAELTNRRRGRLRWFSHSTRSTHSTSSH 467

Query: 1048 MSLPKSTSTGLGEALG 1063
             SLP S +  + E  G
Sbjct: 468  ASLPASDTGSMTETQG 483



 Score =  112 bits (281), Expect = 2e-24
 Identities = 70/260 (26%), Positives = 135/260 (51%), Gaps = 34/260 (13%)

Query: 740  VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGP 799
            V+S  F   + + IL+NT+++ ++++EQ      A++I N+VFT LF +EM+LK++ + P
Sbjct: 1187 VNSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKP 1246

Query: 800  FGYIKNPYNIFDGVIVVISVWEIVGQQ---GG------------GLSVLRTFRLMRVLKL 844
              Y  + +N FD +IVV S+ +I   +   GG             ++  R FR+MR++KL
Sbjct: 1247 KHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKL 1306

Query: 845  VRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRK 904
            +     ++  L   +K+   +    +L+ +  FI++++GM +FG K A + DG  +    
Sbjct: 1307 LSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFG-KVALQ-DGTQINRNN 1364

Query: 905  NFDSLLWAIVTVFQILTQEDWNKVLYNGMAST-----------------SSWAALYFIAL 947
            NF +   A++ +F+  T E W +++   +                    S++A  YFI+ 
Sbjct: 1365 NFQTFPQAVLLLFRCATGEAWQEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISF 1424

Query: 948  MTFGNYVLFNLLVAILVEGF 967
                 +++ NL VA++++ F
Sbjct: 1425 FMLCAFLIINLFVAVIMDNF 1444



 Score =  112 bits (280), Expect = 3e-24
 Identities = 95/386 (24%), Positives = 165/386 (42%), Gaps = 76/386 (19%)

Query: 38   EKDPGSADSEAEGLPYPALAPV----VFFYLSQDSRPRSWCLRTVCNPWFERISMLVILL 93
            E+  G  +   E +P   + P+     FF LSQ +  R  C   + +  F  + ++ I+L
Sbjct: 824  EEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNLILVFIIL 883

Query: 94   NCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDTW- 152
            + V+L    P   I   S R  IL  FD    + F VE+++KM   G F  +     +W 
Sbjct: 884  SSVSLAAEDP---IRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWF 940

Query: 153  NRLDFFIVIAGMLEYSLDLQNVSFSAV-RTVRVLRPLRAINRVPSMRILVTLLLDTLPML 211
            N LD  +V   ++ + +    +S   + R +RVLRPLRAINR   ++ +V  +   +  +
Sbjct: 941  NMLDLLVVSVSLISFGIHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1000

Query: 212  GNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFIC 271
            GN++++   + F+F  +GVQL+ G                                 + C
Sbjct: 1001 GNIMIVTTLLQFMFACIGVQLFKGKF-------------------------------YTC 1029

Query: 272  SQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPF 331
            +   ++  + C+    +  DG    P   +    NS                        
Sbjct: 1030 TDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNSD----------------------- 1066

Query: 332  KGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHS-----FYNF-----IYFILLIIV 381
                NFDN+  A +A+F V T EGW  ++Y  +DA++      YN+     ++FI+ II+
Sbjct: 1067 ---FNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIII 1123

Query: 382  GSFFMINLCLVVIATQFSETKQRESQ 407
             +FFM+N+ +  +   F    ++E Q
Sbjct: 1124 IAFFMMNIFVGFVIITFRAQGEQEYQ 1149



 Score =  104 bits (260), Expect = 6e-22
 Identities = 73/288 (25%), Positives = 131/288 (45%), Gaps = 14/288 (4%)

Query: 1183 LHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRA 1242
            +  +  G+ +  E    NG          L P  P ++G+ +   G  +   R +     
Sbjct: 1    MSESEGGKDTTPEPSPANGAGPGPEWG--LCPGPPAVEGESSGASGLGTPKRRNQHSKHK 58

Query: 1243 RLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERP-KID 1301
             +     +R   + +     +  R  C  I+  K FD ++L+ IF NC+ + +  P   D
Sbjct: 59   TVAVASAQRSPRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPED 118

Query: 1302 PHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDI 1361
              +     L    Y+F  +F  E  +K+VA G      AY+R+ WN+LD ++V++ +  +
Sbjct: 119  DSNTANHNLEQVEYVFLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSV 178

Query: 1362 LVSM-------VSDSGTKILGM-LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIG 1413
            L+            +G K  G  ++ LR  R LRPLR++S    L +V+ ++M +L P+ 
Sbjct: 179  LLEQGPGRPGDAPHTGGKPGGFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLL 238

Query: 1414 NIVVICCAFFIIFGILGVQLFKGKFF-VCQ--GEDTRNITNKSDCAEA 1458
            +I ++     II+ I+G++LF G+    C   G D     + S CA +
Sbjct: 239  HIALLVLFVIIIYAIIGLELFLGRMHKTCYFLGSDMEAEEDPSPCASS 286



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 46/183 (25%), Positives = 97/183 (53%), Gaps = 18/183 (9%)

Query: 1278 FDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFG 1337
            F++++ ++I LN + +AM+    +  +     + + N +FT +F  EM +K++A    F 
Sbjct: 1192 FEYLMFLLILLNTVALAMQH--YEQTAPFNYAMDILNMVFTGLFTIEMVLKIIA----FK 1245

Query: 1338 EQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILG---------MLRVLRLLRTLRP 1388
             + Y   +WN  D L+V+ S++DI V+ V++ G   LG          +   RL R +R 
Sbjct: 1246 PKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGH--LGESSEDSSRISITFFRLFRVMRL 1303

Query: 1389 LRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
            ++++S+ +G++ ++ T + S + +  + ++    F I+ ++G+Q+F GK  +  G     
Sbjct: 1304 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF-GKVALQDGTQINR 1362

Query: 1449 ITN 1451
              N
Sbjct: 1363 NNN 1365



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 56/177 (31%), Positives = 93/177 (52%), Gaps = 17/177 (9%)

Query: 1266 RLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAVF 1321
            R  C R +        VL+++FLN +TIA E      H  + ++LT     +N +   +F
Sbjct: 519  RARCRRAVKSNACYWAVLLLVFLNTLTIASE------HHGQPVWLTQIQEYANKVLLCLF 572

Query: 1322 LAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLR 1381
              EM +K+  LG      AY+ S +N  D  +V   +++   ++V     + LG + VLR
Sbjct: 573  TVEMLLKLYGLG----PSAYVSSFFNRFDCFVVCGGILE--TTLVEVGAMQPLG-ISVLR 625

Query: 1382 LLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
             +R LR  +V      L  +V +L++S+K I +++++   F IIF +LG+QLF GKF
Sbjct: 626  CVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKF 682



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 70/306 (22%), Positives = 140/306 (45%), Gaps = 56/306 (18%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTN-ALEISNIVFTSLFALEMLLKLLVY 797
            ++    F   I++ I+++++S+  E   +     N  L   +  FTS+F +E+LLK+ V+
Sbjct: 867  LIHHHVFTNLILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVF 926

Query: 798  GPF----GYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRF------ 847
            G F     + ++ +N+ D ++V +S+    G     +SV++  R++RVL+ +R       
Sbjct: 927  GAFLHRGSFCRSWFNMLDLLVVSVSLISF-GIHSSAISVVKILRVLRVLRPLRAINRAKG 985

Query: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD----------G 897
            L  + + + V ++T+ N+     LL    F+F+ +G+ LF  KF +  D          G
Sbjct: 986  LKHVVQCVFVAIRTIGNIMIVTTLLQ---FMFACIGVQLFKGKFYTCTDEAKHTPQECKG 1042

Query: 898  DTL--PDRK----------------NFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS- 938
              L  PD                  NFD++L A++ +F + T E W  +LY  + + +  
Sbjct: 1043 SFLVYPDGDVSRPLVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAED 1102

Query: 939  ---------WAALYFIALMTFGNYVLFNLLVAILVEGFQA---EEISKREDASGQLSCIQ 986
                       +++FI  +    + + N+ V  ++  F+A   +E    E    Q  C++
Sbjct: 1103 HGPIYNYRVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVE 1162

Query: 987  LPVDSQ 992
              + +Q
Sbjct: 1163 YALKAQ 1168



 Score = 68.9 bits (167), Expect = 4e-11
 Identities = 48/169 (28%), Positives = 85/169 (50%), Gaps = 11/169 (6%)

Query: 71  RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAV 130
           R+ C R V +       +L++ LN +T+      + +       +I +  +  +   F V
Sbjct: 519 RARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLT----QIQEYANKVLLCLFTV 574

Query: 131 EMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTVRVLR 186
           EM++K+  LG      Y+   +NR D F+V  G+LE +L     +Q +  S +R VR+LR
Sbjct: 575 EMLLKLYGLG---PSAYVSSFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLR 631

Query: 187 PLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
             +      S+  LV  LL+++  + ++LLL F    IF ++G+QL+ G
Sbjct: 632 IFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGG 680



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 53/178 (29%), Positives = 86/178 (48%), Gaps = 25/178 (14%)

Query: 71   RSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFA-FFA 129
            R W   TV +  FE +  L+ILLN V L M +  E  A  +    IL    + +F   F 
Sbjct: 1182 RVWA--TVNSAAFEYLMFLLILLNTVALAM-QHYEQTAPFNYAMDIL----NMVFTGLFT 1234

Query: 130  VEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML--------------EYSLDLQNVS 175
            +EMV+K++A   F  K Y  D WN  D  IV+  ++              E S D   +S
Sbjct: 1235 IEMVLKIIA---FKPKHYFTDAWNTFDALIVVGSIVDIAVTEVNNGGHLGESSEDSSRIS 1291

Query: 176  FSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLW 233
             +  R  RV+R ++ +++   +R L+   + +   L  V LL   +FFI+ ++G+Q++
Sbjct: 1292 ITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMF 1349



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)

Query: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINLC 390
           FD    A + +FQ++T E W  +MY  + A+    F      IYFI+L I G++ ++N+ 
Sbjct: 694 FDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVF 753

Query: 391 LVV 393
           L +
Sbjct: 754 LAI 756



 Score = 31.2 bits (69), Expect = 8.2
 Identities = 14/42 (33%), Positives = 20/42 (47%)

Query: 1114 GRAPSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAG 1155
            G  P +++    G RR     E +E ++EEE  EEE     G
Sbjct: 788  GLVPGVEKEEEEGARREGADMEEEEEEEEEEEEEEEEEGAGG 829


>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
           subunit [Homo sapiens]
          Length = 1873

 Score =  160 bits (406), Expect = 7e-39
 Identities = 93/255 (36%), Positives = 148/255 (58%), Gaps = 15/255 (5%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
           IV SK F   +++ + +NTLS+  E+H QP  LT   +I+N V  SLF  EML+K+   G
Sbjct: 428 IVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLG 487

Query: 799 PFGYIKNPYNIFDGVIVVISVWEIVGQQGG-----GLSVLRTFRLMRVLKLVRFLPALQR 853
              Y  + +N FD  +V   + EI+  + G     G+SVLR  RL+R+ K+ ++  +L  
Sbjct: 488 LRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSN 547

Query: 854 QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLWAI 913
            +  L+ ++ ++A+  +LL LFI IF++LGM LFG ++  E   DT   R NFD+   A+
Sbjct: 548 LVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFE---DTEVRRSNFDNFPQAL 604

Query: 914 VTVFQILTQEDWNKVLYNGMAS------TSSWAALYFIALMTFGNYVLFNLLVAILVEGF 967
           ++VFQ+LT EDW  ++YNG+ +            +YFI L   GNY+L N+ +AI V+  
Sbjct: 605 ISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNL 664

Query: 968 -QAEEISKREDASGQ 981
            +AE ++  + A  +
Sbjct: 665 AEAESLTSAQKAKAE 679



 Score =  155 bits (391), Expect = 4e-37
 Identities = 128/446 (28%), Positives = 203/446 (45%), Gaps = 88/446 (19%)

Query: 49  EGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIA 108
           E LP P   P   F L+ ++  R  C+  V    FE I +L I  NCV L ++ P  +  
Sbjct: 22  EILPRP---PRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDD 78

Query: 109 CDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEY 167
            +S     L+  + F    F++E  +K++A G +F +  YL   WN LDF IV  G+   
Sbjct: 79  NNSLNLG-LEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTV 137

Query: 168 SLDLQNVSFS---------------AVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLG 212
            L+  NV  S               A+R  RVLRPLR ++ VPS+++++  +   +  L 
Sbjct: 138 ILEQVNVIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLF 197

Query: 213 NVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICS 272
           ++ LL  F+  I+ I+G++L+ G +   C+          +  +     ENE+ SP  C+
Sbjct: 198 HIALLVLFMVIIYAIIGLELFKGKMHKTCYF---------IGTDIVATVENEEPSP--CA 246

Query: 273 QPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFK 332
             R    R C    T+ G                              + C  G   P  
Sbjct: 247 --RTGSGRRC----TING------------------------------SECRGGWPGPNH 270

Query: 333 GAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCL 391
           G  +FDN G++ + ++Q IT+EGW D++Y+V DA  + + +IYF+ LI++GSFF++NL L
Sbjct: 271 GITHFDNFGFSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVL 330

Query: 392 VVIATQFSETKQRESQLMREQRVRFLSNASTLASFSEPGSCYEELLKYLVYILRKAARRL 451
            V++ +F  TK+RE    R           T     E     E+L  Y+ +I +      
Sbjct: 331 GVLSGEF--TKEREKAKSR----------GTFQKLREKQQLDEDLRGYMSWITQ------ 372

Query: 452 AQVSRAAGVRVGLLSSPAPLGGQETQ 477
            +V      R G LS     GG +T+
Sbjct: 373 GEVMDVEDFREGKLSLDE--GGSDTE 396



 Score =  132 bits (333), Expect = 2e-30
 Identities = 89/265 (33%), Positives = 142/265 (53%), Gaps = 20/265 (7%)

Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLE-RDSWSAYIFPPQSRFRLLCHRIITHKMFD 1279
            GDD +DE  +    R R     +L    +   ++ S +IF P ++ R+LCHRI+    F 
Sbjct: 743  GDDEEDEPEIPLSPRPRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFT 802

Query: 1280 HVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQ 1339
            + +L+ I L+   +A E P I   S     L   +  FT+VF  E+ +K+   G    + 
Sbjct: 803  NFILLFILLSSAALAAEDP-IRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKG 861

Query: 1340 AYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLK 1399
            ++ R+ +N+LD L+V +S    L+SM  +S    + ++++LR+LR LRPLR I+RA+GLK
Sbjct: 862  SFCRNYFNMLDLLVVAVS----LISMGLESSA--ISVVKILRVLRVLRPLRAINRAKGLK 915

Query: 1400 LVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQG------EDTRN---IT 1450
             VV+ +  ++  IGNIV++      +F  +GVQLFKGKFF C        E+ R    + 
Sbjct: 916  HVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVY 975

Query: 1451 NKSDCAEASYR---WVRHKYNFDNL 1472
               D  +   R   WV   ++FDN+
Sbjct: 976  KDGDPMQIELRHREWVHSDFHFDNV 1000



 Score =  116 bits (290), Expect = 2e-25
 Identities = 106/398 (26%), Positives = 176/398 (44%), Gaps = 78/398 (19%)

Query: 61   FFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAF 120
            FF  S  ++ R  C R V   WF    +L ILL+   L    P   I  DS R +IL+ F
Sbjct: 779  FFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDP---IRADSMRNQILKHF 835

Query: 121  DDFIFAFFAVEMVVKMVALGIF-GKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAV 179
            D    + F VE+V+KM   G F  K  +  + +N LD  +V   ++   L+   +S   +
Sbjct: 836  DIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSAISVVKI 895

Query: 180  -RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLR 238
             R +RVLRPLRAINR   ++ +V  +   +  +GN++L+   + F+F  +GVQL+    +
Sbjct: 896  LRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLF----K 951

Query: 239  NRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPC 298
             + F   + S     +   YY    + +   I  + RE                      
Sbjct: 952  GKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHRE---------------------- 989

Query: 299  GLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVD 358
                             W           H+ F    +FDN+  A +++F V T EGW  
Sbjct: 990  -----------------W----------VHSDF----HFDNVLSAMMSLFTVSTFEGWPQ 1018

Query: 359  IMYFVMDAHS-----FYN-----FIYFILLIIVGSFFMINLCLVVIATQF---SETKQRE 405
            ++Y  +D+++      YN      I+FI+ II+ +FFM+N+ +  +   F    ET+ + 
Sbjct: 1019 LLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKN 1078

Query: 406  SQLMREQR--VRFLSNASTLASFSEPGSCYEELLKYLV 441
             +L + QR  V++   A  L  +  P + Y+  + Y+V
Sbjct: 1079 CELDKNQRQCVQYALKARPLRCYI-PKNPYQYQVWYIV 1115



 Score =  115 bits (289), Expect = 3e-25
 Identities = 73/273 (26%), Positives = 138/273 (50%), Gaps = 46/273 (16%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYG 798
            IV S YF   +   I++NT+ +G++++ Q E++ +  +I N+ FT +F LEM+LKL+ + 
Sbjct: 1114 IVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFK 1173

Query: 799  PFGYIKNPYNIFDGVIVVISVWEIVGQQ--------------GGGL-------------S 831
              GY  +P+N+FD +IV+ S+ +++  +              GGG              +
Sbjct: 1174 ARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSA 1233

Query: 832  VLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF 891
              R FR+MR++KL+     ++  L   +K+   +    +L+++  FI++++GM +FG K 
Sbjct: 1234 FFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG-KI 1292

Query: 892  ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVL----YNGMASTSS--------- 938
            A   DG  +    NF +   A++ +F+  T E W ++L    Y  +    S         
Sbjct: 1293 ALV-DGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT 1351

Query: 939  ----WAALYFIALMTFGNYVLFNLLVAILVEGF 967
                +A  YFI+      +++ NL VA++++ F
Sbjct: 1352 CGTNFAYYYFISFYMLCAFLVINLFVAVIMDNF 1384



 Score =  111 bits (277), Expect = 6e-24
 Identities = 62/198 (31%), Positives = 111/198 (56%), Gaps = 9/198 (4%)

Query: 1249 LERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI-DPHSAER 1307
            L R   + +    ++  R  C  I+  K F+ ++L+ IF NC+ +A+  P   D +++  
Sbjct: 24   LPRPPRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLN 83

Query: 1308 IFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISV-------ID 1360
            + L    Y F  VF  E  +K++A G+ F + AYLRS WNVLD  +V + V       ++
Sbjct: 84   LGLEKLEYFFLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVN 143

Query: 1361 ILVSMVSDSGTKILGM-LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVIC 1419
            ++ S  +   +K  G+ ++ LR  R LRPLR++S    L++V+ ++  ++ P+ +I ++ 
Sbjct: 144  VIQSHTAPMSSKGAGLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLV 203

Query: 1420 CAFFIIFGILGVQLFKGK 1437
                II+ I+G++LFKGK
Sbjct: 204  LFMVIIYAIIGLELFKGK 221



 Score = 93.2 bits (230), Expect = 2e-18
 Identities = 76/295 (25%), Positives = 136/295 (46%), Gaps = 64/295 (21%)

Query: 739 IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEIS----NIVFTSLFALEMLLKL 794
           IV+ K F   I++ I  N +++ + Y   PE+  N+L +        F  +F++E  +K+
Sbjct: 47  IVEWKPFETIILLTIFANCVALAV-YLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKI 105

Query: 795 LVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQQ--------------GGGLSV--LR 834
           + YG       Y+++ +N+ D  IV + V+ ++ +Q              G GL V  LR
Sbjct: 106 IAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALR 165

Query: 835 TFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF------G 888
            FR++R L+LV  +P+LQ  L  + K M  +    +L++  + I++I+G+ LF       
Sbjct: 166 AFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKT 225

Query: 889 CKFASE------------------------------RDGDTLPDR--KNFDSLLWAIVTV 916
           C F                                 R G   P+    +FD+  ++++TV
Sbjct: 226 CYFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTV 285

Query: 917 FQILTQEDWNKVLY-NGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
           +Q +T E W  VLY    A  + W  +YF+ L+  G++ + NL++ +L   F  E
Sbjct: 286 YQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKE 340



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 89/385 (23%), Positives = 171/385 (44%), Gaps = 69/385 (17%)

Query: 665  DSCPYCARAGAGEVELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLG------- 717
            +  P  A+    E E    E+ D    A  +F  D +  +   P S R R L        
Sbjct: 712  EGIPTTAKLKIDEFESNVNEVKDPYPSA--DFPGDDEEDEPEIPLSPRPRPLAELQLKEK 769

Query: 718  --PDAEPSSVLAFW-----RLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE 770
              P  E SS   F      R++C    +IV++ +F   I++ IL+++ ++  E   + + 
Sbjct: 770  AVPIPEASSFFIFSPTNKIRVLC---HRIVNATWFTNFILLFILLSSAALAAEDPIRADS 826

Query: 771  LTNA-LEISNIVFTSLFALEMLLKLLVYGPF----GYIKNPYNIFDGVIVVISVWEIVGQ 825
            + N  L+  +I FTS+F +E++LK+  YG F     + +N +N+ D ++V +S+  + G 
Sbjct: 827  MRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISM-GL 885

Query: 826  QGGGLSVLRTFRLMRVLKLVRFL---PALQRQLVVLMKTMDNVATFCMLLMLFIFIFSIL 882
            +   +SV++  R++RVL+ +R +     L+  +  +   +  +    ++  L  F+F+ +
Sbjct: 886  ESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACI 945

Query: 883  GMHLFGCKFAS------------------ERDGDTLPDRK----------NFDSLLWAIV 914
            G+ LF  KF                     +DGD +              +FD++L A++
Sbjct: 946  GVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMM 1005

Query: 915  TVFQILTQEDWNKVLYNGMASTSS----------WAALYFIALMTFGNYVLFNLLVAILV 964
            ++F + T E W ++LY  + S +             A++FI  +    + + N+ V  ++
Sbjct: 1006 SLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVI 1065

Query: 965  EGFQAE---EISKREDASGQLSCIQ 986
              FQ +   E    E    Q  C+Q
Sbjct: 1066 VTFQEQGETEYKNCELDKNQRQCVQ 1090



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 54/178 (30%), Positives = 99/178 (55%), Gaps = 17/178 (9%)

Query: 1265 FRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT----LSNYIFTAV 1320
            FR  CH I+  K+F  +V++I+ LN ++IA E      H  + ++LT    ++N +  ++
Sbjct: 421  FRWKCHDIVKSKVFYWLVILIVALNTLSIASE------HHNQPLWLTRLQDIANRVLLSL 474

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVL 1380
            F  EM +K+  LG     + Y  S +N  D  +V   +++IL  +V       LG + VL
Sbjct: 475  FTTEMLMKMYGLGL----RQYFMSIFNRFDCFVVCSGILEIL--LVESGAMTPLG-ISVL 527

Query: 1381 RLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKF 1438
            R +R LR  ++      L  +V +L++S++ I +++++   F +IF +LG+QLF G++
Sbjct: 528  RCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRY 585



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 52/210 (24%), Positives = 100/210 (47%), Gaps = 26/210 (12%)

Query: 1261 PQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAV 1320
            P++ ++     I+T   F++++  +I LN I + M+    +          + N  FT +
Sbjct: 1103 PKNPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQH--YNQSEQMNHISDILNVAFTII 1160

Query: 1321 FLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVS-----MVSDSGTKILG 1375
            F  EM +K++A    F  + Y    WNV D L+V+ S+ID+++S     + S  G   LG
Sbjct: 1161 FTLEMILKLMA----FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLG 1216

Query: 1376 --------------MLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCA 1421
                               RL R +R ++++SRA+G++ ++ T + S + +  + ++   
Sbjct: 1217 GGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVM 1276

Query: 1422 FFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
             F I+ ++G+Q+F GK  +  G       N
Sbjct: 1277 LFFIYAVIGMQMF-GKIALVDGTQINRNNN 1305



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 45/182 (24%), Positives = 81/182 (44%), Gaps = 33/182 (18%)

Query: 78   VCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMV 137
            V + +FE +   +I+LN + LGM    +      Q   I    +      F +EM++K++
Sbjct: 1115 VTSSYFEYLMFALIMLNTICLGM----QHYNQSEQMNHISDILNVAFTIIFTLEMILKLM 1170

Query: 138  ALGIFGKKCYLGDTWNRLDFFIVIAGMLEYSL--------------------------DL 171
            A   F  + Y GD WN  DF IVI  +++  L                          + 
Sbjct: 1171 A---FKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDES 1227

Query: 172  QNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQ 231
              +S +  R  RV+R ++ ++R   +R L+   + +   L  V LL   +FFI+ ++G+Q
Sbjct: 1228 ARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1287

Query: 232  LW 233
            ++
Sbjct: 1288 MF 1289



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 54/208 (25%), Positives = 100/208 (48%), Gaps = 15/208 (7%)

Query: 35  GSAEKDPGSADSEAEGLPYPALAPVVFF--YLSQDSRPRSW-CLRTVCNPWFERISMLVI 91
           G    D G +D+E+       L  ++ F  +  Q +R   W C   V +  F  + +L++
Sbjct: 384 GKLSLDEGGSDTESL-YEIAGLNKIIQFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIV 442

Query: 92  LLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIFGKKCYLGDT 151
            LN +++      + +       R+    +  + + F  EM++KM  LG+   + Y    
Sbjct: 443 ALNTLSIASEHHNQPLWLT----RLQDIANRVLLSLFTTEMLMKMYGLGL---RQYFMSI 495

Query: 152 WNRLDFFIVIAGMLEYSL----DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDT 207
           +NR D F+V +G+LE  L     +  +  S +R +R+LR  +      S+  LV  LL++
Sbjct: 496 FNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNS 555

Query: 208 LPMLGNVLLLCFFVFFIFGIVGVQLWAG 235
           +  + ++LLL F    IF ++G+QL+ G
Sbjct: 556 IRSIASLLLLLFLFIVIFALLGMQLFGG 583



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 25/77 (32%), Positives = 43/77 (55%), Gaps = 6/77 (7%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNF------IYFILLIIVGSFFMINL 389
           NFDN   A I++FQV+T E W  +MY  + A+   ++      IYFI+L + G++ ++N+
Sbjct: 596 NFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNV 655

Query: 390 CLVVIATQFSETKQRES 406
            L +     +E +   S
Sbjct: 656 FLAIAVDNLAEAESLTS 672


>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
            sapiens]
          Length = 2506

 Score =  158 bits (399), Expect = 4e-38
 Identities = 157/540 (29%), Positives = 236/540 (43%), Gaps = 55/540 (10%)

Query: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
            R++V ++ F   ++  + +NTL + I ++ QPE L++ L  +  +F  LF  EM +K+  
Sbjct: 480  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 539

Query: 797  YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
             G   Y  + +N FD  +++ S++E++          G+SVLR  RL+R+ K+ ++  +L
Sbjct: 540  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 599

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
            +  +V L+ +M ++ +   LL LFI +F++LGM LFG +F    D  T P   NFD+   
Sbjct: 600  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--NFDEGTPP--TNFDTFPA 655

Query: 912  AIVTVFQILTQEDWNKVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEG 966
            AI+TVFQILT EDWN+V+Y+G+ S          ++YFI L  FGNY L N+ +AI V+ 
Sbjct: 656  AIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 715

Query: 967  F-QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
               A+E++K E    + +  +L +      A  S       S ++      +K    V  
Sbjct: 716  LANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWE 775

Query: 1026 GEHPELRKSLL-----------PPLIIHTAATPMSLPKSTSTGLGEAL--GPASRR---T 1069
                E+RK  L            P     AA    L     T L   L   P   R   T
Sbjct: 776  QRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNT 835

Query: 1070 SSSGSAEP---------GAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLK 1120
            + S +AEP          A   ++           P S ++   +RR    S  +   L 
Sbjct: 836  NKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDP-SGSAGLDARRPWAGS--QEAELS 892

Query: 1121 RRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHR---HRGSLEREAKSSFDLPDT 1177
            R  P G      + EG   Q      E ER   AG  HR   HR    RE++S    P T
Sbjct: 893  REGPYGRESDHHAREGSLEQPGFWEGEAERGK-AGDPHRRHVHRQGGSRESRSG--SPRT 949

Query: 1178 LQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVR 1237
                G HR    R  A       G           R    P  G + + EG    GER R
Sbjct: 950  -GADGEHR----RHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGP-DGGERRR 1003



 Score =  148 bits (373), Expect = 5e-35
 Identities = 117/409 (28%), Positives = 187/409 (45%), Gaps = 79/409 (19%)

Query: 26  SGAGGRPGPGSAEKDPGSADSEAEGL--PYPALAPVV-----FFYLSQDSRPRSWCLRTV 78
           S  GG+PG     K   +  +    L  P P     +      F  S+D+  R +  +  
Sbjct: 36  SRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKIT 95

Query: 79  CNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKM 136
             P FE + +  I+ NC+ L + +  P +D    S+R   L   + +    F  E  +K+
Sbjct: 96  EWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER---LDDTEPYFIGIFCFEAGIKI 152

Query: 137 VALGI-FGKKCYLGDTWNRLDFFIVIAGMLEY---SLDLQNVSFSAVRTVRVLRPLRAIN 192
           +ALG  F K  YL + WN +DF +V+ G+L       DL+ +     R VRVLRPL+ ++
Sbjct: 153 IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTL-----RAVRVLRPLKLVS 207

Query: 193 RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLS 252
            +PS+++++  ++  +  L  + LL FF   IF I+G++ + G     CF          
Sbjct: 208 GIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF---------- 257

Query: 253 VDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTT 312
                    E  D+                         G    PCG +  A       T
Sbjct: 258 --------EEGTDDI-----------------------QGESPAPCGTEEPA------RT 280

Query: 313 CVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-SFYN 371
           C N     T C      P  G   FDNI +A + +FQ IT+EGW D++Y   DA  + +N
Sbjct: 281 CPNG----TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN 336

Query: 372 FIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLMREQRV 414
           ++YFI LII+GSFFM+NL L V++ +F++ ++R        +L R+Q++
Sbjct: 337 WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI 385



 Score =  134 bits (338), Expect = 5e-31
 Identities = 74/227 (32%), Positives = 126/227 (55%), Gaps = 12/227 (5%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
            S +I    +  R LCH I+  + F+  +L++I ++ I +A E P + P++     L   +
Sbjct: 1222 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNAPRNNVLRYFD 1280

Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
            Y+FT VF  EM +K++ LG    + AY R  WN+LD   +++S   +  +   +S  K +
Sbjct: 1281 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD--FIVVSGALVAFAFTGNSKGKDI 1338

Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
              ++ LR+LR LRPL+ I R   LK V + +++SLK + NI+++   F  IF ++ VQLF
Sbjct: 1339 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLF 1398

Query: 1435 KGKFFVCQGE------DTRN---ITNKSDCAEASYRWVRHKYNFDNL 1472
            KGKFF C  E      D R    +  K++       W ++++++DN+
Sbjct: 1399 KGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNV 1445



 Score =  116 bits (290), Expect = 2e-25
 Identities = 71/255 (27%), Positives = 137/255 (53%), Gaps = 24/255 (9%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            + V S  F   IM  I +NT+ + ++++       NAL + NIVFTSLF+LE +LK++ +
Sbjct: 1560 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1619

Query: 798  GPFGYIKNPYNIFDGVIVVISVWEIVGQQGG----GLSVLRTFRLMRVLKLVRFLPALQR 853
            G   Y ++ +NIFD V V+ S+ +I+  + G     LS LR FR  R++KL+R    ++ 
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1679

Query: 854  QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT------LPDRKNFD 907
             L   +++   +   C+L+ +  FI++I+GM +FG       D D+      + +  NF 
Sbjct: 1680 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1739

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGMAST--------------SSWAALYFIALMTFGNY 953
            +   A++ +F+  T E W+ ++ + ++                + +A  YF++ +   ++
Sbjct: 1740 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1799

Query: 954  VLFNLLVAILVEGFQ 968
            ++ NL VA++++ F+
Sbjct: 1800 LMLNLFVAVIMDNFE 1814



 Score =  108 bits (269), Expect = 5e-23
 Identities = 79/276 (28%), Positives = 131/276 (47%), Gaps = 43/276 (15%)

Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
           +KI +   F   I+  I+ N + + +E H   ++ T     L+ +   F  +F  E  +K
Sbjct: 92  KKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151

Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
           ++  G       Y++N +N+ D V+V+  +   VG +   L  LR  R++R LKLV  +P
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD-LRTLRAVRVLRPLKLVSGIP 210

Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF------------------ 891
           +LQ  L  +MK M  +    +LL   I IF+I+G+  +  KF                  
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270

Query: 892 --ASERDGDTLPDR--------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-A 934
              +E    T P+                 FD++L+A++TVFQ +T E W  +LYN   A
Sbjct: 271 PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA 330

Query: 935 STSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
           S ++W  LYFI L+  G++ + NL++ +L   F  E
Sbjct: 331 SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 366



 Score =  100 bits (250), Expect = 8e-21
 Identities = 89/382 (23%), Positives = 155/382 (40%), Gaps = 85/382 (22%)

Query: 38   EKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVT 97
            EK     D   E  P P       F LS  +  R  C   +   +FE   ++VI ++ + 
Sbjct: 1200 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1259

Query: 98   LGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLD 156
            L    P +    ++ R  +L+ FD      F  EMV+KM+ LG +  +  Y  D WN LD
Sbjct: 1260 LAAEDPVQP---NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD 1316

Query: 157  FFIVIAGMLEYSL-------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP 209
            F +V   ++ ++        D+  +   ++R +RVLRPL+ I R+P ++ +   ++++L 
Sbjct: 1317 FIVVSGALVAFAFTGNSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1374

Query: 210  MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPF 269
             + N+L++     FIF +V VQL+ G                                 F
Sbjct: 1375 NVFNILIVYMLFMFIFAVVAVQLFKGKF-------------------------------F 1403

Query: 270  ICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHN 329
             C+   +   + CR    L             YE     +      W +Y          
Sbjct: 1404 HCTDESKEFEKDCRGKYLL-------------YEKNEVKARDR--EWKKY---------- 1438

Query: 330  PFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYN-----------FIYFILL 378
                  ++DN+ +A + +F V T EGW  ++   +DA +F N            I++++ 
Sbjct: 1439 ----EFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA-TFENQGPSPGYRMEMSIFYVVY 1493

Query: 379  IIVGSFFMINLCLVVIATQFSE 400
             +V  FF +N+ + +I   F E
Sbjct: 1494 FVVFPFFFVNIFVALIIITFQE 1515



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 62/203 (30%), Positives = 113/203 (55%), Gaps = 15/203 (7%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
            S ++F   +  R    +I     F++++L  I  NCI +A+E+   D      +ER+  T
Sbjct: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136

Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
               +I   +F  E  +K++ALG+ F + +YLR+ WNV+D ++VL  ++  +       GT
Sbjct: 137  EPYFI--GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV-------GT 187

Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
            +    LR LR +R LRPL+++S    L++V++++M ++ P+  I ++     +IF I+G+
Sbjct: 188  EF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGL 245

Query: 1432 QLFKGKFF-VCQGEDTRNITNKS 1453
            + + GKF   C  E T +I  +S
Sbjct: 246  EFYMGKFHTTCFEEGTDDIQGES 268



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 70/303 (23%), Positives = 140/303 (46%), Gaps = 49/303 (16%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKL--- 794
            I++ +YF   I++ I ++++++  E   QP     N L   + VFT +F  EM++K+   
Sbjct: 1239 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1298

Query: 795  -LVYGPFGYIKNPYNIFDGVIV--VISVWEIVGQQGGG----LSVLRTFRLMRVLKLVRF 847
             LV     Y ++ +NI D ++V   +  +   G   G     +  LR  R++R LK ++ 
Sbjct: 1299 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1358

Query: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------------- 891
            LP L+     ++ ++ NV    ++ MLF+FIF+++ + LF  KF                
Sbjct: 1359 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1418

Query: 892  ---------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
                        RD +      ++D++LWA++T+F + T E W +VL + + +T      
Sbjct: 1419 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1478

Query: 937  ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQLPV 989
                    +++++       +   N+ VA+++  FQ +     E+ S    + +CI   +
Sbjct: 1479 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAI 1538

Query: 990  DSQ 992
             ++
Sbjct: 1539 SAK 1541



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 55/208 (26%), Positives = 108/208 (51%), Gaps = 12/208 (5%)

Query: 1241 RARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1300
            RA + +  LE    S +    + R R    R++  + F   VL ++ LN + +A+     
Sbjct: 454  RASIKSAKLEN---STFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ 510

Query: 1301 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1360
                ++  FL  + +IF  +F++EM +K+  LG     + Y  SS+N  D  +++ S+ +
Sbjct: 511  PEWLSD--FLYYAEFIFLGLFMSEMFIKMYGLG----TRPYFHSSFNCFDCGVIIGSIFE 564

Query: 1361 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1420
            ++ +++    +  + +LR LRLLR  +   V      L+ +V +L++S+K I +++ +  
Sbjct: 565  VIWAVIKPGTSFGISVLRALRLLRIFK---VTKYWASLRNLVVSLLNSMKSIISLLFLLF 621

Query: 1421 AFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
             F ++F +LG+QLF G+F   +G    N
Sbjct: 622  LFIVVFALLGMQLFGGQFNFDEGTPPTN 649



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 64/230 (27%), Positives = 115/230 (50%), Gaps = 25/230 (10%)

Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
            GD   +E +L K ER  A I   + A  L R         PQ++  F+    + +    F
Sbjct: 1517 GDKMMEEYSLEKNER--ACIDFAISAKPLTRHM-------PQNKQSFQYRMWQFVVSPPF 1567

Query: 1279 DHVVLVIIFLNCITIAME--RPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCF 1336
            ++ ++ +I LN I + M+     +   +A R+F    N +FT++F  E  +KV+A    F
Sbjct: 1568 EYTIMAMIALNTIVLMMKFYGASVAYENALRVF----NIVFTSLFSLECVLKVMA----F 1619

Query: 1337 GEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQ 1396
            G   Y R +WN+ D + VL S+ DIL   V++ G   +  L  LRL R  R ++++ +  
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDIL---VTEFGNNFIN-LSFLRLFRAARLIKLLRQGY 1675

Query: 1397 GLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
             +++++ T + S K +  + ++    F I+ I+G+Q+F       + ED+
Sbjct: 1676 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1725



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 16/176 (9%)

Query: 66   QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
            Q  + R W  + V +P FE   M +I LN + L M      +A ++     L+ F+    
Sbjct: 1552 QSFQYRMW--QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA----LRVFNIVFT 1605

Query: 126  AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML-----EYSLDLQNVSFSAVR 180
            + F++E V+K++A GI     Y  D WN  DF  V+  +      E+  +  N+SF  +R
Sbjct: 1606 SLFSLECVLKVMAFGILN---YFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF--LR 1660

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
              R  R ++ + +  ++RIL+   + +   L  V LL   +FFI+ I+G+Q++  +
Sbjct: 1661 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1716



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 8/121 (6%)

Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
           + +FIF   F  EM +KM  LG    + Y   ++N  D  ++I  + E  +++     SF
Sbjct: 520 YAEFIFLGLFMSEMFIKMYGLGT---RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSF 576

Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             S +R +R+LR  +      S+R LV  LL+++  + ++L L F    +F ++G+QL+ 
Sbjct: 577 GISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 636

Query: 235 G 235
           G
Sbjct: 637 G 637



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 5/82 (6%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
           NFD    A + +FQ++T E W ++MY  + +           IYFI+L + G++ ++N+ 
Sbjct: 649 NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVF 708

Query: 391 LVVIATQFSETKQRESQLMREQ 412
           L +     +  ++       E+
Sbjct: 709 LAIAVDNLANAQELTKDEQEEE 730



 Score = 38.1 bits (87), Expect = 0.067
 Identities = 56/252 (22%), Positives = 85/252 (33%), Gaps = 42/252 (16%)

Query: 450  RLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHH----- 504
            R   V    G  + + +    L  +E        +  +    H   HHHHHHHHH     
Sbjct: 2169 RYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRK----HRQHHHHHHHHHHPPPPD 2224

Query: 505  ---YHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPPGGAESVHSFYHADC 561
               Y          RA  +   R  +  R  M     + ++SG+P        +      
Sbjct: 2225 KDRYAQERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTST------ 2278

Query: 562  HLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEK--------ALVEVAAS 613
               P R +   P++PS        S  +     + PP +  +++        A    AA+
Sbjct: 2279 ---PRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQQQAVARPGRAAT 2335

Query: 614  SGP-----PTLTSL--NIPP--GPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGP 664
            SGP     PT   L  + PP  G  S     +E +  G  +S     SP      GA  P
Sbjct: 2336 SGPRRYPGPTAEPLAGDRPPTGGHSSGRSPRMERRVPGPARS----ESPRACRHGGARWP 2391

Query: 665  DSCPYCARAGAG 676
             S P+ +    G
Sbjct: 2392 ASGPHVSEGPPG 2403



 Score = 32.3 bits (72), Expect = 3.7
 Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 21/97 (21%)

Query: 327  EHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM--------------DAHSFYNF 372
            EHN      NF     A + +F+  T E W +IM   +              +  + + +
Sbjct: 1734 EHN------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAY 1787

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
             YF+  I + SF M+NL + VI   F E   R+S ++
Sbjct: 1788 FYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1823


>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
            sapiens]
          Length = 2261

 Score =  158 bits (399), Expect = 4e-38
 Identities = 157/540 (29%), Positives = 236/540 (43%), Gaps = 55/540 (10%)

Query: 737  RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLV 796
            R++V ++ F   ++  + +NTL + I ++ QPE L++ L  +  +F  LF  EM +K+  
Sbjct: 481  RRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYG 540

Query: 797  YGPFGYIKNPYNIFDGVIVVISVWEIVGQ-----QGGGLSVLRTFRLMRVLKLVRFLPAL 851
             G   Y  + +N FD  +++ S++E++          G+SVLR  RL+R+ K+ ++  +L
Sbjct: 541  LGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASL 600

Query: 852  QRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLPDRKNFDSLLW 911
            +  +V L+ +M ++ +   LL LFI +F++LGM LFG +F    D  T P   NFD+   
Sbjct: 601  RNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF--NFDEGTPP--TNFDTFPA 656

Query: 912  AIVTVFQILTQEDWNKVLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEG 966
            AI+TVFQILT EDWN+V+Y+G+ S          ++YFI L  FGNY L N+ +AI V+ 
Sbjct: 657  AIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 716

Query: 967  F-QAEEISKREDASGQLSCIQLPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSL 1025
               A+E++K E    + +  +L +      A  S       S ++      +K    V  
Sbjct: 717  LANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWE 776

Query: 1026 GEHPELRKSLL-----------PPLIIHTAATPMSLPKSTSTGLGEAL--GPASRR---T 1069
                E+RK  L            P     AA    L     T L   L   P   R   T
Sbjct: 777  QRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENRNNNT 836

Query: 1070 SSSGSAEP---------GAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRAPSLK 1120
            + S +AEP          A   ++           P S ++   +RR    S  +   L 
Sbjct: 837  NKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDP-SGSAGLDARRPWAGS--QEAELS 893

Query: 1121 RRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHR---HRGSLEREAKSSFDLPDT 1177
            R  P G      + EG   Q      E ER   AG  HR   HR    RE++S    P T
Sbjct: 894  REGPYGRESDHHAREGSLEQPGFWEGEAERGK-AGDPHRRHVHRQGGSRESRSG--SPRT 950

Query: 1178 LQVPGLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVR 1237
                G HR    R  A       G           R    P  G + + EG    GER R
Sbjct: 951  -GADGEHR----RHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGP-DGGERRR 1004



 Score =  148 bits (373), Expect = 5e-35
 Identities = 117/409 (28%), Positives = 187/409 (45%), Gaps = 79/409 (19%)

Query: 26  SGAGGRPGPGSAEKDPGSADSEAEGL--PYPALAPVV-----FFYLSQDSRPRSWCLRTV 78
           S  GG+PG     K   +  +    L  P P     +      F  S+D+  R +  +  
Sbjct: 36  SRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKIT 95

Query: 79  CNPWFERISMLVILLNCVTLGMFR--PCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKM 136
             P FE + +  I+ NC+ L + +  P +D    S+R   L   + +    F  E  +K+
Sbjct: 96  EWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSER---LDDTEPYFIGIFCFEAGIKI 152

Query: 137 VALGI-FGKKCYLGDTWNRLDFFIVIAGMLEY---SLDLQNVSFSAVRTVRVLRPLRAIN 192
           +ALG  F K  YL + WN +DF +V+ G+L       DL+ +     R VRVLRPL+ ++
Sbjct: 153 IALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTL-----RAVRVLRPLKLVS 207

Query: 193 RVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLS 252
            +PS+++++  ++  +  L  + LL FF   IF I+G++ + G     CF          
Sbjct: 208 GIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCF---------- 257

Query: 253 VDLERYYQTENEDESPFICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTT 312
                    E  D+                         G    PCG +  A       T
Sbjct: 258 --------EEGTDDI-----------------------QGESPAPCGTEEPA------RT 280

Query: 313 CVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-SFYN 371
           C N     T C      P  G   FDNI +A + +FQ IT+EGW D++Y   DA  + +N
Sbjct: 281 CPNG----TKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWN 336

Query: 372 FIYFILLIIVGSFFMINLCLVVIATQFSETKQRES------QLMREQRV 414
           ++YFI LII+GSFFM+NL L V++ +F++ ++R        +L R+Q++
Sbjct: 337 WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQI 385



 Score =  134 bits (338), Expect = 5e-31
 Identities = 74/227 (32%), Positives = 126/227 (55%), Gaps = 12/227 (5%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSN 1314
            S +I    +  R LCH I+  + F+  +L++I ++ I +A E P + P++     L   +
Sbjct: 1223 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDP-VQPNAPRNNVLRYFD 1281

Query: 1315 YIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKIL 1374
            Y+FT VF  EM +K++ LG    + AY R  WN+LD   +++S   +  +   +S  K +
Sbjct: 1282 YVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD--FIVVSGALVAFAFTGNSKGKDI 1339

Query: 1375 GMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1434
              ++ LR+LR LRPL+ I R   LK V + +++SLK + NI+++   F  IF ++ VQLF
Sbjct: 1340 NTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLF 1399

Query: 1435 KGKFFVCQGE------DTRN---ITNKSDCAEASYRWVRHKYNFDNL 1472
            KGKFF C  E      D R    +  K++       W ++++++DN+
Sbjct: 1400 KGKFFHCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNV 1446



 Score =  116 bits (290), Expect = 2e-25
 Identities = 71/255 (27%), Positives = 137/255 (53%), Gaps = 24/255 (9%)

Query: 738  KIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVY 797
            + V S  F   IM  I +NT+ + ++++       NAL + NIVFTSLF+LE +LK++ +
Sbjct: 1561 QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAF 1620

Query: 798  GPFGYIKNPYNIFDGVIVVISVWEIVGQQGG----GLSVLRTFRLMRVLKLVRFLPALQR 853
            G   Y ++ +NIFD V V+ S+ +I+  + G     LS LR FR  R++KL+R    ++ 
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680

Query: 854  QLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDGDT------LPDRKNFD 907
             L   +++   +   C+L+ +  FI++I+GM +FG       D D+      + +  NF 
Sbjct: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFR 1740

Query: 908  SLLWAIVTVFQILTQEDWNKVLYNGMAST--------------SSWAALYFIALMTFGNY 953
            +   A++ +F+  T E W+ ++ + ++                + +A  YF++ +   ++
Sbjct: 1741 TFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSF 1800

Query: 954  VLFNLLVAILVEGFQ 968
            ++ NL VA++++ F+
Sbjct: 1801 LMLNLFVAVIMDNFE 1815



 Score =  108 bits (269), Expect = 5e-23
 Identities = 79/276 (28%), Positives = 131/276 (47%), Gaps = 43/276 (15%)

Query: 737 RKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELT---NALEISNIVFTSLFALEMLLK 793
           +KI +   F   I+  I+ N + + +E H   ++ T     L+ +   F  +F  E  +K
Sbjct: 92  KKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIK 151

Query: 794 LLVYG----PFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 849
           ++  G       Y++N +N+ D V+V+  +   VG +   L  LR  R++R LKLV  +P
Sbjct: 152 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFD-LRTLRAVRVLRPLKLVSGIP 210

Query: 850 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF------------------ 891
           +LQ  L  +MK M  +    +LL   I IF+I+G+  +  KF                  
Sbjct: 211 SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPA 270

Query: 892 --ASERDGDTLPDR--------------KNFDSLLWAIVTVFQILTQEDWNKVLYNGM-A 934
              +E    T P+                 FD++L+A++TVFQ +T E W  +LYN   A
Sbjct: 271 PCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDA 330

Query: 935 STSSWAALYFIALMTFGNYVLFNLLVAILVEGFQAE 970
           S ++W  LYFI L+  G++ + NL++ +L   F  E
Sbjct: 331 SGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKE 366



 Score =  100 bits (250), Expect = 8e-21
 Identities = 89/382 (23%), Positives = 155/382 (40%), Gaps = 85/382 (22%)

Query: 38   EKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVT 97
            EK     D   E  P P       F LS  +  R  C   +   +FE   ++VI ++ + 
Sbjct: 1201 EKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIA 1260

Query: 98   LGMFRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLD 156
            L    P +    ++ R  +L+ FD      F  EMV+KM+ LG +  +  Y  D WN LD
Sbjct: 1261 LAAEDPVQP---NAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILD 1317

Query: 157  FFIVIAGMLEYSL-------DLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLP 209
            F +V   ++ ++        D+  +   ++R +RVLRPL+ I R+P ++ +   ++++L 
Sbjct: 1318 FIVVSGALVAFAFTGNSKGKDINTIK--SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1375

Query: 210  MLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPF 269
             + N+L++     FIF +V VQL+ G                                 F
Sbjct: 1376 NVFNILIVYMLFMFIFAVVAVQLFKGKF-------------------------------F 1404

Query: 270  ICSQPRENGMRSCRSVPTLRGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHN 329
             C+   +   + CR    L             YE     +      W +Y          
Sbjct: 1405 HCTDESKEFEKDCRGKYLL-------------YEKNEVKARDR--EWKKY---------- 1439

Query: 330  PFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYN-----------FIYFILL 378
                  ++DN+ +A + +F V T EGW  ++   +DA +F N            I++++ 
Sbjct: 1440 ----EFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDA-TFENQGPSPGYRMEMSIFYVVY 1494

Query: 379  IIVGSFFMINLCLVVIATQFSE 400
             +V  FF +N+ + +I   F E
Sbjct: 1495 FVVFPFFFVNIFVALIIITFQE 1516



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 62/203 (30%), Positives = 113/203 (55%), Gaps = 15/203 (7%)

Query: 1255 SAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHS---AERIFLT 1311
            S ++F   +  R    +I     F++++L  I  NCI +A+E+   D      +ER+  T
Sbjct: 77   SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDT 136

Query: 1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGT 1371
               +I   +F  E  +K++ALG+ F + +YLR+ WNV+D ++VL  ++  +       GT
Sbjct: 137  EPYFI--GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILATV-------GT 187

Query: 1372 KILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGV 1431
            +    LR LR +R LRPL+++S    L++V++++M ++ P+  I ++     +IF I+G+
Sbjct: 188  EF--DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGL 245

Query: 1432 QLFKGKFF-VCQGEDTRNITNKS 1453
            + + GKF   C  E T +I  +S
Sbjct: 246  EFYMGKFHTTCFEEGTDDIQGES 268



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 70/303 (23%), Positives = 140/303 (46%), Gaps = 49/303 (16%)

Query: 739  IVDSKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKL--- 794
            I++ +YF   I++ I ++++++  E   QP     N L   + VFT +F  EM++K+   
Sbjct: 1240 ILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDL 1299

Query: 795  -LVYGPFGYIKNPYNIFDGVIV--VISVWEIVGQQGGG----LSVLRTFRLMRVLKLVRF 847
             LV     Y ++ +NI D ++V   +  +   G   G     +  LR  R++R LK ++ 
Sbjct: 1300 GLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKR 1359

Query: 848  LPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKF---------------- 891
            LP L+     ++ ++ NV    ++ MLF+FIF+++ + LF  KF                
Sbjct: 1360 LPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEKDCRG 1419

Query: 892  ---------ASERDGDTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMAST------ 936
                        RD +      ++D++LWA++T+F + T E W +VL + + +T      
Sbjct: 1420 KYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGP 1479

Query: 937  ----SSWAALYFIALMTFGNYVLFNLLVAILVEGFQAEEISKREDAS---GQLSCIQLPV 989
                    +++++       +   N+ VA+++  FQ +     E+ S    + +CI   +
Sbjct: 1480 SPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAI 1539

Query: 990  DSQ 992
             ++
Sbjct: 1540 SAK 1542



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 55/208 (26%), Positives = 108/208 (51%), Gaps = 12/208 (5%)

Query: 1241 RARLPACCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKI 1300
            RA + +  LE    S +    + R R    R++  + F   VL ++ LN + +A+     
Sbjct: 455  RASIKSAKLEN---STFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQ 511

Query: 1301 DPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVID 1360
                ++  FL  + +IF  +F++EM +K+  LG     + Y  SS+N  D  +++ S+ +
Sbjct: 512  PEWLSD--FLYYAEFIFLGLFMSEMFIKMYGLG----TRPYFHSSFNCFDCGVIIGSIFE 565

Query: 1361 ILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICC 1420
            ++ +++    +  + +LR LRLLR  +   V      L+ +V +L++S+K I +++ +  
Sbjct: 566  VIWAVIKPGTSFGISVLRALRLLRIFK---VTKYWASLRNLVVSLLNSMKSIISLLFLLF 622

Query: 1421 AFFIIFGILGVQLFKGKFFVCQGEDTRN 1448
             F ++F +LG+QLF G+F   +G    N
Sbjct: 623  LFIVVFALLGMQLFGGQFNFDEGTPPTN 650



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 64/230 (27%), Positives = 115/230 (50%), Gaps = 25/230 (10%)

Query: 1221 GDDADDEGNLSKGERVRAWIRARLPACCLERDSWSAYIFPPQSR--FRLLCHRIITHKMF 1278
            GD   +E +L K ER  A I   + A  L R         PQ++  F+    + +    F
Sbjct: 1518 GDKMMEEYSLEKNER--ACIDFAISAKPLTRHM-------PQNKQSFQYRMWQFVVSPPF 1568

Query: 1279 DHVVLVIIFLNCITIAME--RPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCF 1336
            ++ ++ +I LN I + M+     +   +A R+F    N +FT++F  E  +KV+A    F
Sbjct: 1569 EYTIMAMIALNTIVLMMKFYGASVAYENALRVF----NIVFTSLFSLECVLKVMA----F 1620

Query: 1337 GEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQ 1396
            G   Y R +WN+ D + VL S+ DIL   V++ G   +  L  LRL R  R ++++ +  
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDIL---VTEFGNNFIN-LSFLRLFRAARLIKLLRQGY 1676

Query: 1397 GLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDT 1446
             +++++ T + S K +  + ++    F I+ I+G+Q+F       + ED+
Sbjct: 1677 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDS 1726



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 16/176 (9%)

Query: 66   QDSRPRSWCLRTVCNPWFERISMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF 125
            Q  + R W  + V +P FE   M +I LN + L M      +A ++     L+ F+    
Sbjct: 1553 QSFQYRMW--QFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENA----LRVFNIVFT 1606

Query: 126  AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGML-----EYSLDLQNVSFSAVR 180
            + F++E V+K++A GI     Y  D WN  DF  V+  +      E+  +  N+SF  +R
Sbjct: 1607 SLFSLECVLKVMAFGILN---YFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSF--LR 1661

Query: 181  TVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGL 236
              R  R ++ + +  ++RIL+   + +   L  V LL   +FFI+ I+G+Q++  +
Sbjct: 1662 LFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI 1717



 Score = 51.6 bits (122), Expect = 6e-06
 Identities = 36/121 (29%), Positives = 64/121 (52%), Gaps = 8/121 (6%)

Query: 120 FDDFIF-AFFAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVIAGMLE--YSLDLQNVSF 176
           + +FIF   F  EM +KM  LG    + Y   ++N  D  ++I  + E  +++     SF
Sbjct: 521 YAEFIFLGLFMSEMFIKMYGLGT---RPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSF 577

Query: 177 --SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWA 234
             S +R +R+LR  +      S+R LV  LL+++  + ++L L F    +F ++G+QL+ 
Sbjct: 578 GISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFG 637

Query: 235 G 235
           G
Sbjct: 638 G 638



 Score = 39.7 bits (91), Expect = 0.023
 Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 5/82 (6%)

Query: 336 NFDNIGYAWIAIFQVITLEGWVDIMYFVMDAH-----SFYNFIYFILLIIVGSFFMINLC 390
           NFD    A + +FQ++T E W ++MY  + +           IYFI+L + G++ ++N+ 
Sbjct: 650 NFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVF 709

Query: 391 LVVIATQFSETKQRESQLMREQ 412
           L +     +  ++       E+
Sbjct: 710 LAIAVDNLANAQELTKDEQEEE 731



 Score = 34.7 bits (78), Expect = 0.74
 Identities = 10/13 (76%), Positives = 11/13 (84%)

Query: 493  HLVHHHHHHHHHY 505
            H  HHHHHHHHH+
Sbjct: 2208 HRQHHHHHHHHHH 2220



 Score = 33.9 bits (76), Expect = 1.3
 Identities = 15/55 (27%), Positives = 21/55 (38%), Gaps = 4/55 (7%)

Query: 450  RLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSCSRSHRRLSVHHLVHHHHHHHHH 504
            R   V    G  + + +    L  +E        +  +    H   HHHHHHHHH
Sbjct: 2170 RYTDVDTGLGTDLSMTTQSGDLPSKERDQERGRPKDRK----HRQHHHHHHHHHH 2220



 Score = 33.1 bits (74), Expect = 2.1
 Identities = 9/10 (90%), Positives = 10/10 (100%)

Query: 497  HHHHHHHHYH 506
            HHHHHHHH+H
Sbjct: 2211 HHHHHHHHHH 2220



 Score = 32.3 bits (72), Expect = 3.7
 Identities = 26/97 (26%), Positives = 42/97 (43%), Gaps = 21/97 (21%)

Query: 327  EHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVM--------------DAHSFYNF 372
            EHN      NF     A + +F+  T E W +IM   +              +  + + +
Sbjct: 1735 EHN------NFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAY 1788

Query: 373  IYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLM 409
             YF+  I + SF M+NL + VI   F E   R+S ++
Sbjct: 1789 FYFVSFIFLCSFLMLNLFVAVIMDNF-EYLTRDSSIL 1824


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,699,364
Number of Sequences: 37866
Number of extensions: 3478642
Number of successful extensions: 24624
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 403
Number of HSP's that attempted gapping in prelim test: 17846
Number of HSP's gapped (non-prelim): 3956
length of query: 1555
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1439
effective length of database: 13,855,062
effective search space: 19937434218
effective search space used: 19937434218
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.