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Search of human proteins with 38201692
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
(834 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38201692 RAS p21 protein activator 3 [Homo sapiens] 1694 0.0
gi|12545408 RAS p21 protein activator 2 [Homo sapiens] 1058 0.0
gi|4759026 RAS protein activator like 1 [Homo sapiens] 362 e-100
gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens] 334 2e-91
gi|239743307 PREDICTED: similar to calcium-promoted Ras inactiva... 301 1e-81
gi|239508990 PREDICTED: similar to calcium-promoted Ras inactiva... 301 1e-81
gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens] 298 1e-80
gi|239743309 PREDICTED: similar to calcium-promoted Ras inactiva... 283 4e-76
gi|239508992 PREDICTED: similar to calcium-promoted Ras inactiva... 283 4e-76
gi|41281683 disabled homolog 2 interacting protein isoform 2 [Ho... 134 3e-31
gi|94967023 disabled homolog 2 interacting protein isoform 1 [Ho... 134 3e-31
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 133 6e-31
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 133 6e-31
gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens] 132 1e-30
gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens] 132 1e-30
gi|194248068 synaptic Ras GTPase activating protein 1 [Homo sapi... 125 1e-28
gi|130502162 RAS protein activator like 3 [Homo sapiens] 123 8e-28
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 107 3e-23
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 98 3e-20
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 75 2e-13
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 75 2e-13
gi|92859638 synaptotagmin V [Homo sapiens] 70 1e-11
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 68 3e-11
gi|209447073 synaptotagmin I [Homo sapiens] 66 2e-10
gi|5032139 synaptotagmin I [Homo sapiens] 66 2e-10
gi|209447070 synaptotagmin I [Homo sapiens] 66 2e-10
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 65 3e-10
gi|211059429 synaptotagmin II [Homo sapiens] 64 6e-10
gi|31543670 synaptotagmin II [Homo sapiens] 64 6e-10
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 62 2e-09
>gi|38201692 RAS p21 protein activator 3 [Homo sapiens]
Length = 834
Score = 1694 bits (4387), Expect = 0.0
Identities = 834/834 (100%), Positives = 834/834 (100%)
Query: 1 MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPF 60
MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPF
Sbjct: 1 MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPF 60
Query: 61 YGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDAD 120
YGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDAD
Sbjct: 61 YGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDAD 120
Query: 121 SEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEA 180
SEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEA
Sbjct: 121 SEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEA 180
Query: 181 KKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGD 240
KKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGD
Sbjct: 181 KKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGD 240
Query: 241 EFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
EFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY
Sbjct: 241 EFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
Query: 301 SPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEV 360
SPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEV
Sbjct: 301 SPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEV 360
Query: 361 KRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDG 420
KRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDG
Sbjct: 361 KRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDG 420
Query: 421 ENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSS 480
ENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSS
Sbjct: 421 ENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSS 480
Query: 481 FIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMAT 540
FIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMAT
Sbjct: 481 FIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMAT 540
Query: 541 FYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKK 600
FYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKK
Sbjct: 541 FYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKK 600
Query: 601 RWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQAN 660
RWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQAN
Sbjct: 601 RWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQAN 660
Query: 661 NCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANI 720
NCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANI
Sbjct: 661 NCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANI 720
Query: 721 QLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQEEYSTFVIDDPQETYKTL 780
QLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQEEYSTFVIDDPQETYKTL
Sbjct: 721 QLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQEEYSTFVIDDPQETYKTL 780
Query: 781 KQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI 834
KQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI
Sbjct: 781 KQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI 834
>gi|12545408 RAS p21 protein activator 2 [Homo sapiens]
Length = 849
Score = 1058 bits (2736), Expect = 0.0
Identities = 503/817 (61%), Positives = 651/817 (79%), Gaps = 8/817 (0%)
Query: 8 LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYC 67
+RV QS++ KI EAKNL Y GP KMRDC+CT+NLDQEEV+RT++VEKSL PF+ E+FY
Sbjct: 34 VRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYF 93
Query: 68 EIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEVQGKV 127
EIPR+F++LSFY++D++V +RD IGKVAI+KEDL + ++TWF LQ VD++SEVQGKV
Sbjct: 94 EIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKV 153
Query: 128 HLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAKKTKVK 186
HLEL+L+E+IT+ G VC +L I C GLP++NGQ CDPYATV+L GP R++ KKTKVK
Sbjct: 154 HLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVK 213
Query: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGEL 246
+KT+NPQF+E+FYFEVTR SY++KS F EEED++KLEIR+DLWN NL D FLGE+
Sbjct: 214 KKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDVFLGEI 272
Query: 247 RIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDL 306
++P+ VLR SS++AWY LQPRDNG+KS K DDLGSLRLN+ YTED+V S+YY PL+ L
Sbjct: 273 KVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTL 332
Query: 307 LLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
LLKS DV+P+SASAA+IL E+CR+K +A +PLVRL LH+ ++VPF +A+A ++K TQD
Sbjct: 333 LLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQDA 392
Query: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENN 426
NTIFRGNSLA++C+DE MK+ G HYL VTLKP ++EIC S K CEIDP+KLK+G+N+ENN
Sbjct: 393 NTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENN 452
Query: 427 MENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRF 486
ENLR YVD++F+ I +S +SCPTVMCDIF+SLR+ A +RF +DP V+Y+AVSSF+FLRF
Sbjct: 453 KENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRF 512
Query: 487 FAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTL---GSLSKSKSASFKESYMATFYE 543
FA A++SP+ F L PHH D QT RTLTLISKT+QTL GSLSKSKS SFKE++M F++
Sbjct: 513 FAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFMCEFFK 571
Query: 544 FFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNFKKRWF 603
F E+ Y AVK FLD ISS+ ++ +P+ LKEG M KRAQGR R G KNFKKRWF
Sbjct: 572 MFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWF 631
Query: 604 RLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYIQANNCV 663
LT+ E TYHK G +Y+IP++NILAVEKLEE SF KNMFQVI E+ LY+QANNCV
Sbjct: 632 CLTSRELTYHKQPGKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCV 691
Query: 664 EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLPANIQLD 723
EA +WID+L +VS+CNQ RL+ YHPS YL+G+WLCC+ ++ GC PCT G+PA+IQ+D
Sbjct: 692 EANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQID 751
Query: 724 IDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQETYKTLK 781
ID DRETERIYSLF L + KL+KM+EACG+ +VY GP++E +YS FVI+D T+KT++
Sbjct: 752 IDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQ 811
Query: 782 QVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKS 818
Q+ + + L++ H +Y++ + KYGS+E+PI K+
Sbjct: 812 QIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKA 848
>gi|4759026 RAS protein activator like 1 [Homo sapiens]
Length = 804
Score = 362 bits (930), Expect = e-100
Identities = 248/755 (32%), Positives = 378/755 (50%), Gaps = 63/755 (8%)
Query: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
S+ +++ E + LP+ S D YC V +D E V RT V +SL PF+GE++ +P
Sbjct: 6 SLNVRVVEGRALPA-KDVSGSSDPYCLVKVDDEVVARTATVWRSLGPFWGEEYTVHLPLD 64
Query: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKY-HNRDTWFQLQHVDADSEVQGKVHLEL 131
F L+FY+ D D D IIGK+++ +E + D+W L VD D+EVQG++ L +
Sbjct: 65 FHQLAFYVLDEDTVGHDDIIGKISLSREAITADPRGIDSWINLSRVDPDAEVQGEICLSV 124
Query: 132 RLSEVITDTGVVCHKLATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNN 191
++ E + CH L R + + ++G DP+A V + S++ +T +KT
Sbjct: 125 QMLEDGQGRCLRCHVLHARDLAPRD---ISGTSDPFARVF----WGSQSLETSTIKKTRF 177
Query: 192 PQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLK 251
P +DEV + E +RV+LW+ + D FLG + K
Sbjct: 178 PHWDEVL----------------ELREMPGAPSPLRVELWDWDMVGKND-FLGMVEFSPK 220
Query: 252 VLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSA 311
L+Q + W+ L P + +LG+LR+ V ED V S Y PL +LL++S
Sbjct: 221 TLQQKPP-KGWFRLLPFPRAEED-SGGNLGALRVKVRLIEDRVLPSQCYQPLMELLMESV 278
Query: 312 D--VEPVSASAAHILGEV----CREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQD 365
E +AS +L E+ CR Q+ A LV+LFL G F+ + EV RT D
Sbjct: 279 QGPAEEDTASPLALLEELTLGDCR--QDLATKLVKLFLGRGLAGHFLDYLTRREVARTMD 336
Query: 366 PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK--------- 416
PNT+FR NSLASK +++ MKL GM YLH LKP I + + K E+DP K
Sbjct: 337 PNTLFRSNSLASKSMEQFMKLVGMPYLHEVLKPVISRVFEEKKYMELDPCKMDLGRTRRI 396
Query: 417 -----LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QD 469
L + + E ++ L Y+ + AI S CP M F L +RF +
Sbjct: 397 SFKGALSEEQMRETSLGLLTGYLGPIVDAIVGSVGRCPPAMRLAFKQLHRRVEERFPQAE 456
Query: 470 DPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSK 529
DV+Y A+S F+FLRFFAPAIL+P LF L H DPQTSR+L L++K VQ++G+L +
Sbjct: 457 HQDVKYLAISGFLFLRFFAPAILTPKLFDLRDQHADPQTSRSLLLLAKAVQSIGNLGQQL 516
Query: 530 SASFKESYMATFYEFFNE--QKYADAVKNFLDLISSSGRRDPKSVEQP-IVLKEGFMIKR 586
KE +MA + F + + D + +D+ +++ P +++EG+++KR
Sbjct: 517 GQG-KELWMAPLHPFLLQCVSRVRDFLDRLVDVDGDEAGVPARALFPPSAIVREGYLLKR 575
Query: 587 AQGRKRFGMK-NFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNM 645
+ + FKKR+ L+ ++ KS Q +SIP+ +I AVE+++E +F++ ++
Sbjct: 576 KEEPAGLATRFAFKKRYVWLSGETLSFSKSPEWQMCHSIPVSHIRAVERVDEGAFQLPHV 635
Query: 646 FQVIQPE-----RALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCR 700
QV+ + Y+Q N E W+ L K S N +L HP A+ S W CC
Sbjct: 636 MQVVTQDGTGALHTTYLQCKNVNELNQWLSALRKASAPNPNKLAACHPGAFRSARWTCCL 695
Query: 701 APSDSAPGCSPCTGGLPANIQLD-IDGDRETERIY 734
SA GCS + D +D D E + +Y
Sbjct: 696 QAERSAAGCSRTHSAVTLGDWSDPLDPDAEAQTVY 730
>gi|121114294 RAS p21 protein activator 4 isoform 1 [Homo sapiens]
Length = 803
Score = 334 bits (857), Expect = 2e-91
Identities = 228/730 (31%), Positives = 362/730 (49%), Gaps = 63/730 (8%)
Query: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
S+ I+I E KNLP+ + D YC V +D E + RT V K+LCPF+GE++ +P +
Sbjct: 6 SLYIRIVEGKNLPA-KDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLEL 131
F ++FY+ D D RD +IGKV + ++ + + + W L VD D EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 132 RLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKT 189
+ G +L ++E + L NG DP+ V ++ ++T + +K+
Sbjct: 125 EVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKS 175
Query: 190 NNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIP 249
P+++E F FE+ +E ++ L + W+ L ++FLG++ I
Sbjct: 176 CYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVID 218
Query: 250 LKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLK 309
++ LR E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL
Sbjct: 219 VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCH 278
Query: 310 SADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
+ L E +Q+ A L++LFL G F+ + E+ RT +
Sbjct: 279 EVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSET 338
Query: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK-------- 418
NT+FR NSLASK ++ +K+AGM YLH L P I ++ + K E+DP K++
Sbjct: 339 NTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSG 398
Query: 419 ------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDD 470
+ E LE + + LR ++ + A++ S +CP V+ F L +RF
Sbjct: 399 LHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQH 458
Query: 471 PDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKS 530
+V + AV+SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S
Sbjct: 459 ENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPAS 518
Query: 531 ASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMI 584
+ KE++M ++ +K+F+ + +D +++ + L KEG I
Sbjct: 519 RA-KEAWMEPLQP--TVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 585 KRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKN 644
R +G+ +FKK +F LT ++ K+ + I + NI A EK+EE+SF +
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSH 635
Query: 645 MFQVIQPERA-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCC 699
+ QVI + A Y+Q E W+ L KVS N L YHP + W CC
Sbjct: 636 VMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCC 695
Query: 700 RAPSDSAPGC 709
+ GC
Sbjct: 696 HQKEKTGQGC 705
>gi|239743307 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 757
Score = 301 bits (772), Expect = 1e-81
Identities = 220/752 (29%), Positives = 351/752 (46%), Gaps = 102/752 (13%)
Query: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
S+ I+I E KNLP+ + D YC V +D E + RT V K+LCPF+GE++ +P +
Sbjct: 6 SLYIRIVEGKNLPA-KDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLEL 131
F ++FY+ D D RD +IGKV + ++ + + + W L VD D EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 132 RLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKT 189
+ G +L ++E + L NG DP+ V ++ ++T + +K+
Sbjct: 125 EVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKS 175
Query: 190 NNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIP 249
P+++E F FE+ +E ++ L + W+ L ++FLG++ I
Sbjct: 176 CYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVID 218
Query: 250 LKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLK 309
++ LR E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL
Sbjct: 219 VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCH 278
Query: 310 SADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
+ L E +Q+ A L++LFL G F+ + E+ RT +
Sbjct: 279 EVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSET 338
Query: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK-------- 418
NT+FR NSLASK ++ +K+AGM YLH L P I ++ + K E+DP K++
Sbjct: 339 NTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSG 398
Query: 419 ------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDD 470
+ E LE + + LR ++ + A++ S +CP V+ F L +RF
Sbjct: 399 LHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQH 458
Query: 471 PDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKS 530
+V + AV+SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S
Sbjct: 459 ENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPAS 518
Query: 531 ASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMI 584
+ KE++M ++ +K+F+ + +D +++ + L KEG I
Sbjct: 519 RA-KEAWMEPLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 585 KRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKN 644
R +G+ +FKK +F LT ++ K+
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKT----------------------------- 606
Query: 645 MFQVIQPERALYIQANNCV-EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPS 703
++ CV E W+ L KVS N L YHP + W CC
Sbjct: 607 -------------PSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 704 DSAPGCSPCTGGLPANIQLD-IDGDRETERIY 734
+ GC + D +D D E + IY
Sbjct: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIY 685
>gi|239508990 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 757
Score = 301 bits (772), Expect = 1e-81
Identities = 220/752 (29%), Positives = 351/752 (46%), Gaps = 102/752 (13%)
Query: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
S+ I+I E KNLP+ + D YC V +D E + RT V K+LCPF+GE++ +P +
Sbjct: 6 SLYIRIVEGKNLPA-KDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLEL 131
F ++FY+ D D RD +IGKV + ++ + + + W L VD D EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 132 RLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKT 189
+ G +L ++E + L NG DP+ V ++ ++T + +K+
Sbjct: 125 EVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKS 175
Query: 190 NNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIP 249
P+++E F FE+ +E ++ L + W+ L ++FLG++ I
Sbjct: 176 CYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVID 218
Query: 250 LKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLK 309
++ LR E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL
Sbjct: 219 VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCH 278
Query: 310 SADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
+ L E +Q+ A L++LFL G F+ + E+ RT +
Sbjct: 279 EVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSET 338
Query: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK-------- 418
NT+FR NSLASK ++ +K+AGM YLH L P I ++ + K E+DP K++
Sbjct: 339 NTLFRSNSLASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSG 398
Query: 419 ------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDD 470
+ E LE + + LR ++ + A++ S +CP V+ F L +RF
Sbjct: 399 LHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQH 458
Query: 471 PDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKS 530
+V + AV+SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S
Sbjct: 459 ENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPAS 518
Query: 531 ASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMI 584
+ KE++M ++ +K+F+ + +D +++ + L KEG I
Sbjct: 519 RA-KEAWMEPLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 585 KRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKN 644
R +G+ +FKK +F LT ++ K+
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKT----------------------------- 606
Query: 645 MFQVIQPERALYIQANNCV-EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPS 703
++ CV E W+ L KVS N L YHP + W CC
Sbjct: 607 -------------PSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 704 DSAPGCSPCTGGLPANIQLD-IDGDRETERIY 734
+ GC + D +D D E + IY
Sbjct: 654 KTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIY 685
>gi|121114292 RAS p21 protein activator 4 isoform 2 [Homo sapiens]
Length = 757
Score = 298 bits (763), Expect = 1e-80
Identities = 214/726 (29%), Positives = 342/726 (47%), Gaps = 101/726 (13%)
Query: 13 SVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRS 72
S+ I+I E KNLP+ + D YC V +D E + RT V K+LCPF+GE++ +P +
Sbjct: 6 SLYIRIVEGKNLPA-KDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPT 64
Query: 73 FRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLEL 131
F ++FY+ D D RD +IGKV + ++ + + + W L VD D EVQG++HL L
Sbjct: 65 FHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRL 124
Query: 132 RLSEVITDTGVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKT 189
+ G +L ++E + L NG DP+ V ++ ++T + +K+
Sbjct: 125 EVWP-----GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKS 175
Query: 190 NNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIP 249
P+++E F FE+ +E ++ L + W+ L ++FLG++ I
Sbjct: 176 CYPRWNETFEFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVID 218
Query: 250 LKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLK 309
++ LR E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL
Sbjct: 219 VQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCH 278
Query: 310 SADVEPVSASAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDP 366
+ L E +Q+ A L++LFL G F+ + E+ RT +
Sbjct: 279 EVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSET 338
Query: 367 NTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK-------- 418
NT+FR NSLASK ++ +K+AGM YLH L P I ++ + K E+DP K++
Sbjct: 339 NTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSG 398
Query: 419 ------DGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDD 470
+ E LE + + LR ++ + A++ S +CP V+ F L +RF
Sbjct: 399 LHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQH 458
Query: 471 PDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKS 530
+V + AV+SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S
Sbjct: 459 ENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPAS 518
Query: 531 ASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMI 584
+ KE++M ++ +K+F+ + +D +++ + L KEG I
Sbjct: 519 RA-KEAWMEPLQP--TVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFI 575
Query: 585 KRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKN 644
R +G+ +FKK +F LT ++ K+
Sbjct: 576 HRTKGKGPLMSSSFKKLYFSLTTEALSFAKT----------------------------- 606
Query: 645 MFQVIQPERALYIQANNCV-EAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPS 703
++ CV E W+ L KVS N L YHP + W CC
Sbjct: 607 -------------PSSKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKE 653
Query: 704 DSAPGC 709
+ GC
Sbjct: 654 KTGQGC 659
>gi|239743309 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 2 [Homo sapiens]
Length = 731
Score = 283 bits (725), Expect = 4e-76
Identities = 206/687 (29%), Positives = 328/687 (47%), Gaps = 63/687 (9%)
Query: 82 DRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLELRLSEVITDT 140
D D RD +IGKV + ++ + + + W L VD D EVQG++HL L +
Sbjct: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWP----- 56
Query: 141 GVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVF 198
G +L ++E + L NG DP+ V ++ ++T + +K+ P+++E F
Sbjct: 57 GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKSCYPRWNETF 112
Query: 199 YFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSS 258
FE+ +E ++ L + W+ L ++FLG++ I ++ LR
Sbjct: 113 EFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVIDVQRLRVVQQ 155
Query: 259 YEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSA 318
E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL +
Sbjct: 156 EEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 319 SAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSL 375
L E +Q+ A L++LFL G F+ + E+ RT + NT+FR NSL
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSL 275
Query: 376 ASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK--------------DGE 421
ASK ++ +K+AGM YLH L P I ++ + K E+DP K++ + E
Sbjct: 276 ASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAE 335
Query: 422 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDDPDVRYTAVS 479
LE + + LR ++ + A++ S +CP V+ F L +RF +V + AV+
Sbjct: 336 VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVT 395
Query: 480 SFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMA 539
SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S + KE++M
Sbjct: 396 SFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRA-KEAWME 454
Query: 540 TFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMIKRAQGRKRF 593
++ +K+F+ + +D +++ + L KEG I R +G+
Sbjct: 455 PLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
Query: 594 GMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 653
+FKK +F LT ++ K+ + I + NI A EK+EE+SF ++ QVI +
Sbjct: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
Query: 654 A-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPG 708
A Y+Q E W+ L KVS N L YHP + W CC + G
Sbjct: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
Query: 709 CSPCTGGLPANIQLD-IDGDRETERIY 734
C + D +D D E + IY
Sbjct: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIY 659
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 50 TKIVEKSLCPFYGEDFYCEIPR-SFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNR 108
T IV+KS P + E F E+ + L +D D+ R+ +GKV I + L+
Sbjct: 97 TSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 109 DTWFQLQHVDADSEVQ-----GKVHLELRLSE 135
+ WF+LQ + S G + LE+RL +
Sbjct: 157 EGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRD 188
>gi|239508992 PREDICTED: similar to calcium-promoted Ras inactivator
isoform 1 [Homo sapiens]
Length = 731
Score = 283 bits (725), Expect = 4e-76
Identities = 206/687 (29%), Positives = 328/687 (47%), Gaps = 63/687 (9%)
Query: 82 DRDVFRRDSIIGKVAIQKEDLQKYHNRDT-WFQLQHVDADSEVQGKVHLELRLSEVITDT 140
D D RD +IGKV + ++ + + + W L VD D EVQG++HL L +
Sbjct: 2 DEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWP----- 56
Query: 141 GVVCHKLATRIVECQGLPIV--NGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVF 198
G +L ++E + L NG DP+ V ++ ++T + +K+ P+++E F
Sbjct: 57 GARACRLRCSVLEARDLAPKDRNGTSDPFVRVR----YKGRTRETSIVKKSCYPRWNETF 112
Query: 199 YFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSS 258
FE+ +E ++ L + W+ L ++FLG++ I ++ LR
Sbjct: 113 EFEL--------------QEGAMEALCVEAWDWD---LVSRNDFLGKVVIDVQRLRVVQQ 155
Query: 259 YEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSA 318
E W+ LQP + S+ +LGSL+L V ++ V S YY PL LL +
Sbjct: 156 EEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGP 215
Query: 319 SAAHILGEVCRE---KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSL 375
L E +Q+ A L++LFL G F+ + E+ RT + NT+FR NSL
Sbjct: 216 GQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSL 275
Query: 376 ASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLK--------------DGE 421
ASK ++ +K+AGM YLH L P I ++ + K E+DP K++ + E
Sbjct: 276 ASKSVESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAE 335
Query: 422 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRF--QDDPDVRYTAVS 479
LE + + LR ++ + A++ S +CP V+ F L +RF +V + AV+
Sbjct: 336 VLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVT 395
Query: 480 SFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMA 539
SF+ LRFF+PAI+SP LF L H D +TSRTL L++K VQ +G++ S + KE++M
Sbjct: 396 SFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRA-KEAWME 454
Query: 540 TFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVL-----KEG-FMIKRAQGRKRF 593
++ +K+F+ + +D +++ + L KEG I R +G+
Sbjct: 455 PLQPTVHQG--VAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPL 512
Query: 594 GMKNFKKRWFRLTNHEFTYHKSKGDQPLYSIPIENILAVEKLEEESFKMKNMFQVIQPER 653
+FKK +F LT ++ K+ + I + NI A EK+EE+SF ++ QVI +
Sbjct: 513 MSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDD 572
Query: 654 A-----LYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPG 708
A Y+Q E W+ L KVS N L YHP + W CC + G
Sbjct: 573 AGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQG 632
Query: 709 CSPCTGGLPANIQLD-IDGDRETERIY 734
C + D +D D E + IY
Sbjct: 633 CDKTRSRVTLQEWNDPLDHDLEAQLIY 659
Score = 40.8 bits (94), Expect = 0.005
Identities = 28/92 (30%), Positives = 44/92 (47%), Gaps = 6/92 (6%)
Query: 50 TKIVEKSLCPFYGEDFYCEIPR-SFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNR 108
T IV+KS P + E F E+ + L +D D+ R+ +GKV I + L+
Sbjct: 97 TSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQE 156
Query: 109 DTWFQLQHVDADSEVQ-----GKVHLELRLSE 135
+ WF+LQ + S G + LE+RL +
Sbjct: 157 EGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRD 188
>gi|41281683 disabled homolog 2 interacting protein isoform 2 [Homo
sapiens]
Length = 1065
Score = 134 bits (337), Expect = 3e-31
Identities = 111/391 (28%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE---FL 243
R T + D VF+ E HF+F + + V L+ ++ K E +L
Sbjct: 120 RTTGKLKTDNVFWGE-----------HFEFHNLPPLRT-VTVHLYRETDKKKKKERNSYL 167
Query: 244 GELRIPLKVLRQSSSYEAWY-FLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSP 302
G + +P + E WY + P G K P +R+ Y + + Y
Sbjct: 168 GLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMYKE 223
Query: 303 LRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIAS 357
+ + A +EP+ ++ + K+E A LV + G+V F++ +
Sbjct: 224 FAEHITNHYLGLCAALEPILSA---------KTKEEMASALVHILQSTGKVKDFLTDLMM 274
Query: 358 AEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK 416
+EV R D + IFR N+LA+K I+E +KL G YL L I+ + +S + CE+DP K
Sbjct: 275 SEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK 334
Query: 417 LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYT 476
+ L + NL+ + F I S P + ++F S R+ + R + PD+
Sbjct: 335 CSAAD-LPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGR--PDISER 391
Query: 477 AVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKES 536
+S+ +FLRF PAI+SP+LF L + D +T+RTLTLI+K Q L + +K S S
Sbjct: 392 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMS 451
Query: 537 YMATF--YEFFNEQKYADAVKNFLDLISSSG 565
+M F +E+ N Q++ + N L +++G
Sbjct: 452 FMNQFLEHEWTNMQRFLLEISNPETLSNTAG 482
>gi|94967023 disabled homolog 2 interacting protein isoform 1 [Homo
sapiens]
Length = 1132
Score = 134 bits (337), Expect = 3e-31
Identities = 111/391 (28%), Positives = 183/391 (46%), Gaps = 40/391 (10%)
Query: 187 RKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE---FL 243
R T + D VF+ E HF+F + + V L+ ++ K E +L
Sbjct: 216 RTTGKLKTDNVFWGE-----------HFEFHNLPPLRT-VTVHLYRETDKKKKKERNSYL 263
Query: 244 GELRIPLKVLRQSSSYEAWY-FLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSP 302
G + +P + E WY + P G K P +R+ Y + + Y
Sbjct: 264 GLVSLPAASVAGRQFVEKWYPVVTPNPKGGKGPGP----MIRIKARYQTITILPMEMYKE 319
Query: 303 LRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIAS 357
+ + A +EP+ ++ + K+E A LV + G+V F++ +
Sbjct: 320 FAEHITNHYLGLCAALEPILSA---------KTKEEMASALVHILQSTGKVKDFLTDLMM 370
Query: 358 AEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVK 416
+EV R D + IFR N+LA+K I+E +KL G YL L I+ + +S + CE+DP K
Sbjct: 371 SEVDRCGDNEHLIFRENTLATKAIEEYLKLVGQKYLQDALGEFIKALYESDENCEVDPSK 430
Query: 417 LKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYT 476
+ L + NL+ + F I S P + ++F S R+ + R + PD+
Sbjct: 431 CSAAD-LPEHQGNLKMCCELAFCKIINSYCVFPRELKEVFASWRQECSSRGR--PDISER 487
Query: 477 AVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKES 536
+S+ +FLRF PAI+SP+LF L + D +T+RTLTLI+K Q L + +K S S
Sbjct: 488 LISASLFLRFLCPAIMSPSLFNLLQEYPDDRTARTLTLIAKVTQNLANFAKFGSKEEYMS 547
Query: 537 YMATF--YEFFNEQKYADAVKNFLDLISSSG 565
+M F +E+ N Q++ + N L +++G
Sbjct: 548 FMNQFLEHEWTNMQRFLLEISNPETLSNTAG 578
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 133 bits (335), Expect = 6e-31
Identities = 103/405 (25%), Positives = 185/405 (45%), Gaps = 36/405 (8%)
Query: 147 LATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPC 206
L I E LP+ + +PY + L + KT R+ NP + E F F+ P
Sbjct: 596 LVLHIEEAHKLPVKHFT-NPYCNIYLNSV---QVAKTHA-REGQNPVWSEEFVFDDLPP- 649
Query: 207 SYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQ 266
D+++ EI + + K D + +R L L++ + + W+ L
Sbjct: 650 -------------DINRFEITL---SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL- 692
Query: 267 PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGE 326
+ LK + GSLR+ Y+ + + + YS ++L+L+ + L
Sbjct: 693 ---SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALSH 743
Query: 327 VC-REKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMK 385
VC +++ A L+R+FLH + + E+ + T+FR +LAS +++ MK
Sbjct: 744 VCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMK 803
Query: 386 LAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESG 445
++H LK +I +I +S + CE+ P KL+ E++ N+ +L + + I +
Sbjct: 804 ATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS 863
Query: 446 VSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTD 505
P + I+ L+++ ++ + +R VS F+FLR PAIL+P +F +
Sbjct: 864 EILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 923
Query: 506 PQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550
P +RTL L++K+VQ L +L + + KE YM F K+
Sbjct: 924 PIAARTLILVAKSVQNLANLVEFGA---KEPYMEGVNPFIKSNKH 965
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 7/129 (5%)
Query: 8 LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDF-Y 66
LR S+ + I EA LP + YC + L+ +V +T E P + E+F +
Sbjct: 590 LRQVSSLVLHIEEAHKLPV----KHFTNPYCNIYLNSVQVAKTHAREGQN-PVWSEEFVF 644
Query: 67 CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQL-QHVDADSEVQG 125
++P + ++ +D I + Q LQK H D WF L H+ G
Sbjct: 645 DDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 704
Query: 126 KVHLELRLS 134
+ + R S
Sbjct: 705 SLRVRARYS 713
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 133 bits (335), Expect = 6e-31
Identities = 103/405 (25%), Positives = 185/405 (45%), Gaps = 36/405 (8%)
Query: 147 LATRIVECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPC 206
L I E LP+ + +PY + L + KT R+ NP + E F F+ P
Sbjct: 419 LVLHIEEAHKLPVKHFT-NPYCNIYLNSV---QVAKTHA-REGQNPVWSEEFVFDDLPP- 472
Query: 207 SYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQ 266
D+++ EI + + K D + +R L L++ + + W+ L
Sbjct: 473 -------------DINRFEITL---SNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLL- 515
Query: 267 PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGE 326
+ LK + GSLR+ Y+ + + + YS ++L+L+ + L
Sbjct: 516 ---SSHIPLKGIEPGSLRVRARYSMEKIMPEEEYSEFKELILQK------ELHVVYALSH 566
Query: 327 VC-REKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMK 385
VC +++ A L+R+FLH + + E+ + T+FR +LAS +++ MK
Sbjct: 567 VCGQDRTLLASILLRIFLHEKLESLLLCTLNDREISMEDEATTLFRATTLASTLMEQYMK 626
Query: 386 LAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESG 445
++H LK +I +I +S + CE+ P KL+ E++ N+ +L + + I +
Sbjct: 627 ATATQFVHHALKDSILKIMESKQSCELSPSKLEKNEDVNTNLTHLLNILSELVEKIFMAS 686
Query: 446 VSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTD 505
P + I+ L+++ ++ + +R VS F+FLR PAIL+P +F +
Sbjct: 687 EILPPTLRYIYGCLQKSVQHKWPTNTTMRTRVVSGFVFLRLICPAILNPRMFNIISDSPS 746
Query: 506 PQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550
P +RTL L++K+VQ L +L + + KE YM F K+
Sbjct: 747 PIAARTLILVAKSVQNLANLVEFGA---KEPYMEGVNPFIKSNKH 788
Score = 36.2 bits (82), Expect = 0.13
Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 7/129 (5%)
Query: 8 LRVFQSVKIKIGEAKNLPSYPGPSKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGEDF-Y 66
LR S+ + I EA LP + YC + L+ +V +T E P + E+F +
Sbjct: 413 LRQVSSLVLHIEEAHKLPV----KHFTNPYCNIYLNSVQVAKTHAREGQN-PVWSEEFVF 467
Query: 67 CEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQL-QHVDADSEVQG 125
++P + ++ +D I + Q LQK H D WF L H+ G
Sbjct: 468 DDLPPDINRFEITLSNKTKKSKDPDILFMRCQLSRLQKGHATDEWFLLSSHIPLKGIEPG 527
Query: 126 KVHLELRLS 134
+ + R S
Sbjct: 528 SLRVRARYS 536
>gi|226958575 RAS protein activator like 2 isoform 2 [Homo sapiens]
Length = 1280
Score = 132 bits (332), Expect = 1e-30
Identities = 114/389 (29%), Positives = 183/389 (47%), Gaps = 42/389 (10%)
Query: 182 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 241
+T K K +N + E F F + P +S H +DV+K K +
Sbjct: 348 RTTSKTKADNIFWGEHFEF-FSLPPLHSITVHI---YKDVEK----------KKKKDKNN 393
Query: 242 FLGELRIPLKVLRQSSSYEAWYFLQ-PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
++G + IP + E WY + P N K+ P S+R+ + + + Y
Sbjct: 394 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 449
Query: 301 SPLRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAI 355
+ + + + +EPV + R K+E A LV + GR F++ +
Sbjct: 450 KEFAEFVTSNYTMLCSVLEPVIS---------VRNKEELACALVHILQSTGRAKDFLTDL 500
Query: 356 ASAEVKRTQDPNT-IFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDP 414
+EV R + + IFR N++A+K I+E +KL G YLH L I+ + +S + CE+DP
Sbjct: 501 VMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDP 560
Query: 415 VKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVR 474
K E L ++ NL+ + F I S P + ++F S ++ R + D R
Sbjct: 561 SKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISER 619
Query: 475 YTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFK 534
+S+ +FLRF PAI+SP+LF L + D +TSRTLTLI+K +Q L + +K + K
Sbjct: 620 L--ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN---K 674
Query: 535 ESYMATFYEFFNEQKYADAVKNFLDLISS 563
E YMA +F + +K FL IS+
Sbjct: 675 EEYMAFMNDFLEHE--WGGMKRFLLEISN 701
>gi|4758808 RAS protein activator like 2 isoform 1 [Homo sapiens]
Length = 1139
Score = 132 bits (332), Expect = 1e-30
Identities = 114/389 (29%), Positives = 183/389 (47%), Gaps = 42/389 (10%)
Query: 182 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE 241
+T K K +N + E F F + P +S H +DV+K K +
Sbjct: 200 RTTSKTKADNIFWGEHFEF-FSLPPLHSITVHI---YKDVEK----------KKKKDKNN 245
Query: 242 FLGELRIPLKVLRQSSSYEAWYFLQ-PRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYY 300
++G + IP + E WY + P N K+ P S+R+ + + + Y
Sbjct: 246 YVGLVNIPTASVTGRQFVEKWYPVSTPTPNKGKTGGP----SIRIKSRFQTITILPMEQY 301
Query: 301 SPLRDLLLKS-----ADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAI 355
+ + + + +EPV + R K+E A LV + GR F++ +
Sbjct: 302 KEFAEFVTSNYTMLCSVLEPVIS---------VRNKEELACALVHILQSTGRAKDFLTDL 352
Query: 356 ASAEVKRTQDPNT-IFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDP 414
+EV R + + IFR N++A+K I+E +KL G YLH L I+ + +S + CE+DP
Sbjct: 353 VMSEVDRCGEHDVLIFRENTIATKSIEEYLKLVGQQYLHDALGEFIKALYESDENCEVDP 412
Query: 415 VKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVR 474
K E L ++ NL+ + F I S P + ++F S ++ R + D R
Sbjct: 413 SKCSSSE-LIDHQSNLKMCCELAFCKIINSYCVFPRELKEVFASWKQQCLNRGKQDISER 471
Query: 475 YTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFK 534
+S+ +FLRF PAI+SP+LF L + D +TSRTLTLI+K +Q L + +K + K
Sbjct: 472 L--ISASLFLRFLCPAIMSPSLFNLMQEYPDDRTSRTLTLIAKVIQNLANFAKFGN---K 526
Query: 535 ESYMATFYEFFNEQKYADAVKNFLDLISS 563
E YMA +F + +K FL IS+
Sbjct: 527 EEYMAFMNDFLEHE--WGGMKRFLLEISN 553
>gi|194248068 synaptic Ras GTPase activating protein 1 [Homo
sapiens]
Length = 1343
Score = 125 bits (315), Expect = 1e-28
Identities = 115/406 (28%), Positives = 187/406 (46%), Gaps = 51/406 (12%)
Query: 195 DEVFYFEVT-RPCSYSKKSHFDFEEEDVDKLE----IRVDLWNASNLKFGDE---FLGEL 246
D++ Y T +P S S + F E + + L +R+ L+ S+ K + ++G +
Sbjct: 287 DDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLV 346
Query: 247 RIPLKVLRQSSSYEAWY--FLQPRDNGSKSLKPDDLG---------------SLRLNVVY 289
+P+ L E WY L GS + G ++RL Y
Sbjct: 347 TVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARY 406
Query: 290 TEDHVFSSDYYSPLRDLL-----LKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLH 344
+ + Y + + + A +EP A ++ G K+E A LV +
Sbjct: 407 QTMSILPMELYKEFAEYVTNHYRMLCAVLEP----ALNVKG-----KEEVASALVHILQS 457
Query: 345 YGRVVPFISAIASAEVKRTQD-PNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEI 403
G+ F+S +A +EV R + + IFR N+LA+K I+E M+L G YL + I +
Sbjct: 458 TGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRAL 517
Query: 404 CQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAA 463
+S + CE+DP+K +L + NLR + + S P + ++F S R
Sbjct: 518 YESEENCEVDPIKCT-ASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRC 576
Query: 464 AKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG 523
A+R ++D + +S+ +FLRF PAI+SP+LF L + D QTSRTLTLI+K +Q L
Sbjct: 577 AERGRED--IADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLA 634
Query: 524 SLSKSKSASFKESYMATFYEFF-----NEQKYADAVKNFLDLISSS 564
+ SK S KE ++ EF + Q++ + N L +SS
Sbjct: 635 NFSKFTS---KEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSS 677
>gi|130502162 RAS protein activator like 3 [Homo sapiens]
Length = 1011
Score = 123 bits (308), Expect = 8e-28
Identities = 83/233 (35%), Positives = 118/233 (50%), Gaps = 9/233 (3%)
Query: 331 KQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTI-FRGNSLASKCIDETMKLAGM 389
K+E A +VR+ GR ++ + +AE+ R + FR N+LA+K IDE MKL
Sbjct: 459 KEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQ 518
Query: 390 HYLHVTLKPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCP 449
YL TL + +C S + CE+DP K E L + LR + VF I S P
Sbjct: 519 DYLQETLGQVVRRLCASTEDCEVDPSKCPASE-LPEHQARLRNSCEEVFETIIHSYDWFP 577
Query: 450 TVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTS 509
+ +F S REA +R + R S +FLR PAIL+P+LF L P H P +
Sbjct: 578 AELGIVFSSWREACKERGSEVLGPRLVCAS--LFLRLLCPAILAPSLFGLAPDHPAPGPA 635
Query: 510 RTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLIS 562
RTLTLI+K +Q L + + KE+YM F E + A++ FLD ++
Sbjct: 636 RTLTLIAKVIQNLANRAPFGE---KEAYMGFMNSFLEE--HGPAMQCFLDQVA 683
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 107 bits (268), Expect = 3e-23
Identities = 81/258 (31%), Positives = 123/258 (47%), Gaps = 14/258 (5%)
Query: 315 PVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNS 374
P++ + A+++ C + E A LV LF + + + S EV+ T+FRGNS
Sbjct: 1222 PIAMALANVVP--CSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNS 1279
Query: 375 LASKCIDETMKLAGMHYLHVTLKPAIEEICQS----HKPCEIDPVKLKDGENLENNMENL 430
LASK + K+ G YL L P + + S H E+DP +L+ E+LE N NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 431 RQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPA 490
Q ++ FHAI S P + + L + ++RF P AV S +FLRF PA
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQVVSQRF---PQNSIGAVGSAMFLRFINPA 1396
Query: 491 ILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSASFKESYMATFYEFFNEQKY 550
I+SP + P+ R L L+SK +Q++ + KE +M F +F + +
Sbjct: 1397 IVSPYEAGILDKKPPPRIERGLKLMSKILQSIA----NHVLFTKEEHMRPFNDFV-KSNF 1451
Query: 551 ADAVKNFLDLISSSGRRD 568
A + FLD+ S D
Sbjct: 1452 DAARRFFLDIASDCPTSD 1469
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 98.2 bits (243), Expect = 3e-20
Identities = 82/276 (29%), Positives = 125/276 (45%), Gaps = 29/276 (10%)
Query: 315 PVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNS 374
P++ + A+++ C + E A LV LF + + + S EV+ T+FRGNS
Sbjct: 1222 PIAMALANVVP--CSQWDELARVLVTLFDSRHLLYQLLWNMFSKEVELADSMQTLFRGNS 1279
Query: 375 LASKCIDETMKLAGMHYLHVTLKPAIEEICQS----HKPCEIDPVKLKDGENLENNMENL 430
LASK + K+ G YL L P + + S H E+DP +L+ E+LE N NL
Sbjct: 1280 LASKIMTFCFKVYGATYLQKLLDPLLRIVITSSDWQHVSFEVDPTRLEPSESLEENQRNL 1339
Query: 431 RQYVDRVFHAITESGVSCPTVM---CDIFFS------LREAAAKRFQDD---------PD 472
Q ++ FHAI S P + C + L +A K +++ P
Sbjct: 1340 LQMTEKFFHAIISSSSEFPPQLRSVCHCLYQATCHSLLNKATVKEKKENKKSVVSQRFPQ 1399
Query: 473 VRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLGSLSKSKSAS 532
AV S +FLRF PAI+SP + P+ R L L+SK +Q++ +
Sbjct: 1400 NSIGAVGSAMFLRFINPAIVSPYEAGILDKKPPPRIERGLKLMSKILQSIA----NHVLF 1455
Query: 533 FKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRD 568
KE +M F +F + + A + FLD+ S D
Sbjct: 1456 TKEEHMRPFNDFV-KSNFDAARRFFLDIASDCPTSD 1490
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 75.5 bits (184), Expect = 2e-13
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 6/137 (4%)
Query: 580 EGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYH---KSKGDQPLYSIPIENILAVEKL- 635
E ++KR+Q +K+ N+K+R F LT +Y+ K K SI I+ I VEK+
Sbjct: 8 EELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVN 67
Query: 636 --EEESFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLS 693
E+ + + FQ++ + LY+ A+N W+ L K + N L YH ++
Sbjct: 68 LEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVD 127
Query: 694 GHWLCCRAPSDSAPGCS 710
G +LCC+ +APGC+
Sbjct: 128 GKFLCCQQSCKAAPGCT 144
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 75.5 bits (184), Expect = 2e-13
Identities = 43/137 (31%), Positives = 70/137 (51%), Gaps = 6/137 (4%)
Query: 580 EGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYH---KSKGDQPLYSIPIENILAVEKL- 635
E ++KR+Q +K+ N+K+R F LT +Y+ K K SI I+ I VEK+
Sbjct: 8 EELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKIRCVEKVN 67
Query: 636 --EEESFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLS 693
E+ + + FQ++ + LY+ A+N W+ L K + N L YH ++
Sbjct: 68 LEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKYHSGFFVD 127
Query: 694 GHWLCCRAPSDSAPGCS 710
G +LCC+ +APGC+
Sbjct: 128 GKFLCCQQSCKAAPGCT 144
>gi|92859638 synaptotagmin V [Homo sapiens]
Length = 386
Score = 69.7 bits (169), Expect = 1e-11
Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 18/199 (9%)
Query: 35 DCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFYCEIPR---SFRHLSFYIFDRDVFRRD 89
D Y V L D+ + TK+ ++L P +GE F ++P R L ++D D F R+
Sbjct: 145 DPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFKVPYVELGGRVLVMAVYDFDRFSRN 204
Query: 90 SIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEVQ-GKVHLELRLSEVITDTGVVCHKLA 148
IG+V + + W +LQ + + + G + LR + G KL
Sbjct: 205 DAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKLGDICFSLRY---VPTAG----KLT 257
Query: 149 TRIVECQGLPI--VNGQCDPYATV-TLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRP 205
++E + L V G DPY V L G + KKT +K+ T NP ++E F FEV P
Sbjct: 258 VIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKNTLNPYYNEAFSFEV--P 315
Query: 206 CSYSKKSHFDFEEEDVDKL 224
C +K + D DKL
Sbjct: 316 CDQVQKVQVELTVLDYDKL 334
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/162 (29%), Positives = 73/162 (45%), Gaps = 29/162 (17%)
Query: 577 VLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYH-----KSKGDQPLYSIPIENILA 631
V+ E +KR+Q +K+ NFKKR F LT H+ +Y+ + + SI +E I
Sbjct: 4 VILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITC 63
Query: 632 VEKLE---------------EESFKMKNM---------FQVIQPERALYIQANNCVEAKD 667
VE + EES +M+ + FQV+ E LY+ + K
Sbjct: 64 VETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKR 123
Query: 668 WIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGC 709
WI L V + N + YHP ++ G +LCC + +A GC
Sbjct: 124 WIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGC 165
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 19/203 (9%)
Query: 11 FQSVKIKIG--EAKNLPSYPGPSKMRDCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFY 66
FQ+ ++ +G +A LP+ D Y V L D+++ F TK+ K+L P + E F
Sbjct: 154 FQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 67 CEIPRSF---RHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEV 123
++P S + L ++D D F + IIG+ + + H + W LQ + + +
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQE 272
Query: 124 Q-GKVHLELRLSEVITDTGVVCHKLATRIVECQGLPI--VNGQCDPYATVTLA-GPFRSE 179
+ G + LR + G KL I+E + L V G DPY + L R +
Sbjct: 273 KLGDICFSLRY---VPTAG----KLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 325
Query: 180 AKKTKVKRKTNNPQFDEVFYFEV 202
KKT +K+ T NP ++E F FEV
Sbjct: 326 KKKTTIKKNTLNPYYNESFSFEV 348
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 118 DADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVN--GQCDPYATVTLAGP 175
D + + + K +L + D ++L I++ LP ++ G DPY V L P
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL-P 188
Query: 176 FRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASN 235
+ + +TKV RKT NP F+E F F+V P S D D+
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKV--PYSELGGKTLVMAVYDFDRFSKH-------- 238
Query: 236 LKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLR 284
+ +GE ++P+ + E W LQ + + D SLR
Sbjct: 239 -----DIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLR 282
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 19/203 (9%)
Query: 11 FQSVKIKIG--EAKNLPSYPGPSKMRDCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFY 66
FQ+ ++ +G +A LP+ D Y V L D+++ F TK+ K+L P + E F
Sbjct: 154 FQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 67 CEIPRSF---RHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEV 123
++P S + L ++D D F + IIG+ + + H + W LQ + + +
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQE 272
Query: 124 Q-GKVHLELRLSEVITDTGVVCHKLATRIVECQGLPI--VNGQCDPYATVTLA-GPFRSE 179
+ G + LR + G KL I+E + L V G DPY + L R +
Sbjct: 273 KLGDICFSLRY---VPTAG----KLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 325
Query: 180 AKKTKVKRKTNNPQFDEVFYFEV 202
KKT +K+ T NP ++E F FEV
Sbjct: 326 KKKTTIKKNTLNPYYNESFSFEV 348
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 118 DADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVN--GQCDPYATVTLAGP 175
D + + + K +L + D ++L I++ LP ++ G DPY V L P
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL-P 188
Query: 176 FRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASN 235
+ + +TKV RKT NP F+E F F+V P S D D+
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKV--PYSELGGKTLVMAVYDFDRFSKH-------- 238
Query: 236 LKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLR 284
+ +GE ++P+ + E W LQ + + D SLR
Sbjct: 239 -----DIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLR 282
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 65.9 bits (159), Expect = 2e-10
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 19/203 (9%)
Query: 11 FQSVKIKIG--EAKNLPSYPGPSKMRDCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFY 66
FQ+ ++ +G +A LP+ D Y V L D+++ F TK+ K+L P + E F
Sbjct: 154 FQNNQLLVGIIQAAELPALD-MGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 67 CEIPRSF---RHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSEV 123
++P S + L ++D D F + IIG+ + + H + W LQ + + +
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQE 272
Query: 124 Q-GKVHLELRLSEVITDTGVVCHKLATRIVECQGLPI--VNGQCDPYATVTLA-GPFRSE 179
+ G + LR + G KL I+E + L V G DPY + L R +
Sbjct: 273 KLGDICFSLRY---VPTAG----KLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 325
Query: 180 AKKTKVKRKTNNPQFDEVFYFEV 202
KKT +K+ T NP ++E F FEV
Sbjct: 326 KKKTTIKKNTLNPYYNESFSFEV 348
Score = 42.4 bits (98), Expect = 0.002
Identities = 43/169 (25%), Positives = 68/169 (40%), Gaps = 18/169 (10%)
Query: 118 DADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVN--GQCDPYATVTLAGP 175
D + + + K +L + D ++L I++ LP ++ G DPY V L P
Sbjct: 130 DGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLL-P 188
Query: 176 FRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASN 235
+ + +TKV RKT NP F+E F F+V P S D D+
Sbjct: 189 DKKKKFETKVHRKTLNPVFNEQFTFKV--PYSELGGKTLVMAVYDFDRFSKH-------- 238
Query: 236 LKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLR 284
+ +GE ++P+ + E W LQ + + D SLR
Sbjct: 239 -----DIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLR 282
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 65.1 bits (157), Expect = 3e-10
Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 6/136 (4%)
Query: 580 EGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLYS--IPIENILAVEKLEE 637
E +IKR+Q +K+ N+K+R F LT TY++ + ++ I + I VE ++
Sbjct: 8 EEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIKCVEIVKN 67
Query: 638 ES----FKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLS 693
+ + K FQV+ LYI A + W+ L + + N + YHP +
Sbjct: 68 DDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKYHPKFWTD 127
Query: 694 GHWLCCRAPSDSAPGC 709
G + CCR APGC
Sbjct: 128 GSYQCCRQTEKLAPGC 143
>gi|211059429 synaptotagmin II [Homo sapiens]
Length = 419
Score = 63.9 bits (154), Expect = 6e-10
Identities = 68/225 (30%), Positives = 102/225 (45%), Gaps = 21/225 (9%)
Query: 11 FQSVKIKIG--EAKNLPSYPGPSKMRDCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFY 66
FQ+ ++ +G +A LP+ D Y V L D+++ + TK+ K+L P + E F
Sbjct: 151 FQANQLTVGVLQAAELPALD-MGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFT 209
Query: 67 CEIPRSF---RHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADS-E 122
++P + L I+D D F + IIG+V + + + W LQ + + E
Sbjct: 210 FKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPE 269
Query: 123 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPI--VNGQCDPYATVTLA-GPFRSE 179
G + LR + G KL I+E + L V G DPY + L R +
Sbjct: 270 KLGDICTSLRY---VPTAG----KLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 322
Query: 180 AKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKL 224
KKT VK+KT NP F+E F FE+ P +K D DKL
Sbjct: 323 KKKTTVKKKTLNPYFNESFSFEI--PFEQIQKVQVVVTVLDYDKL 365
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/147 (24%), Positives = 68/147 (46%), Gaps = 22/147 (14%)
Query: 145 HKLATRIVECQGLPIVN--GQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEV 202
++L +++ LP ++ G DPY V L P + + +TKV RKT NP F+E F F+V
Sbjct: 154 NQLTVGVLQAAELPALDMGGTSDPYVKVFLL-PDKKKKYETKVHRKTLNPAFNETFTFKV 212
Query: 203 TRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAW 262
+++ + + +++ D +GE+++P+ + E W
Sbjct: 213 PY--------------QELGGKTLVMAIYDFDRFSKHD-IIGEVKVPMNTVDLGQPIEEW 257
Query: 263 YFLQPRDNGSKSLKPDDLGSLRLNVVY 289
LQ G + +P+ LG + ++ Y
Sbjct: 258 RDLQ----GGEKEEPEKLGDICTSLRY 280
>gi|31543670 synaptotagmin II [Homo sapiens]
Length = 419
Score = 63.9 bits (154), Expect = 6e-10
Identities = 68/225 (30%), Positives = 102/225 (45%), Gaps = 21/225 (9%)
Query: 11 FQSVKIKIG--EAKNLPSYPGPSKMRDCYCTVNL--DQEEVFRTKIVEKSLCPFYGEDFY 66
FQ+ ++ +G +A LP+ D Y V L D+++ + TK+ K+L P + E F
Sbjct: 151 FQANQLTVGVLQAAELPALD-MGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFT 209
Query: 67 CEIPRSF---RHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADS-E 122
++P + L I+D D F + IIG+V + + + W LQ + + E
Sbjct: 210 FKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPE 269
Query: 123 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPI--VNGQCDPYATVTLA-GPFRSE 179
G + LR + G KL I+E + L V G DPY + L R +
Sbjct: 270 KLGDICTSLRY---VPTAG----KLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLK 322
Query: 180 AKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKL 224
KKT VK+KT NP F+E F FE+ P +K D DKL
Sbjct: 323 KKKTTVKKKTLNPYFNESFSFEI--PFEQIQKVQVVVTVLDYDKL 365
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/147 (24%), Positives = 68/147 (46%), Gaps = 22/147 (14%)
Query: 145 HKLATRIVECQGLPIVN--GQCDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEV 202
++L +++ LP ++ G DPY V L P + + +TKV RKT NP F+E F F+V
Sbjct: 154 NQLTVGVLQAAELPALDMGGTSDPYVKVFLL-PDKKKKYETKVHRKTLNPAFNETFTFKV 212
Query: 203 TRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAW 262
+++ + + +++ D +GE+++P+ + E W
Sbjct: 213 PY--------------QELGGKTLVMAIYDFDRFSKHD-IIGEVKVPMNTVDLGQPIEEW 257
Query: 263 YFLQPRDNGSKSLKPDDLGSLRLNVVY 289
LQ G + +P+ LG + ++ Y
Sbjct: 258 RDLQ----GGEKEEPEKLGDICTSLRY 280
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 62.4 bits (150), Expect = 2e-09
Identities = 39/140 (27%), Positives = 66/140 (47%), Gaps = 6/140 (4%)
Query: 577 VLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQPLY---SIPIENILAVE 633
+L E +IK++Q ++R NFK R+F LT Y + + + SI + I VE
Sbjct: 5 ILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE 64
Query: 634 KLEEE---SFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSA 690
++ + K FQV+ LY+ A + + W+ L + ++ N + YHP+
Sbjct: 65 IVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNF 124
Query: 691 YLSGHWLCCRAPSDSAPGCS 710
++ G W CC A GC+
Sbjct: 125 WMDGKWRCCSQLEKLATGCA 144
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,478,075
Number of Sequences: 37866
Number of extensions: 1439276
Number of successful extensions: 4067
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 3653
Number of HSP's gapped (non-prelim): 362
length of query: 834
length of database: 18,247,518
effective HSP length: 111
effective length of query: 723
effective length of database: 14,044,392
effective search space: 10154095416
effective search space used: 10154095416
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.