Search of human proteins with 38045898

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
         (1116 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...  2133   0.0  
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]  2066   0.0  
gi|34577114 cytomatrix protein p110 [Homo sapiens]                   1189   0.0  
gi|21735548 centrosomal protein 2 [Homo sapiens]                      171   4e-42
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]            165   3e-40
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   161   3e-39
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   161   3e-39
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   161   3e-39
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   161   3e-39
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...   161   3e-39
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        158   3e-38
gi|38044112 restin isoform b [Homo sapiens]                           154   6e-37
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]   152   2e-36
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    151   3e-36
gi|4506751 restin isoform a [Homo sapiens]                            151   4e-36
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   150   6e-36
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   149   1e-35
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                  149   2e-35
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    146   1e-34
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   146   1e-34
gi|156104908 myosin heavy chain 6 [Homo sapiens]                      144   5e-34
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...   144   5e-34
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...   144   6e-34
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...   144   6e-34
gi|118498356 kinectin 1 isoform a [Homo sapiens]                      142   1e-33
gi|33620775 kinectin 1 isoform a [Homo sapiens]                       142   1e-33
gi|55770834 centromere protein F [Homo sapiens]                       142   2e-33
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...   141   3e-33
gi|148746195 trichohyalin [Homo sapiens]                              140   5e-33
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...   140   5e-33

>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens]
          Length = 1116

 Score = 2133 bits (5528), Expect = 0.0
 Identities = 1116/1116 (100%), Positives = 1116/1116 (100%)

Query: 1    MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
            MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
Sbjct: 1    MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60

Query: 61   SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
            SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
Sbjct: 61   SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120

Query: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
            DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
Sbjct: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180

Query: 181  SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
            SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
Sbjct: 181  SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240

Query: 241  DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
            DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
Sbjct: 241  DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300

Query: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
            TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
Sbjct: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360

Query: 361  REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
            REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
Sbjct: 361  REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480
            EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT
Sbjct: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480

Query: 481  ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 540
            ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
Sbjct: 481  ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 540

Query: 541  KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 600
            KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER
Sbjct: 541  KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 600

Query: 601  VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
            VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK
Sbjct: 601  VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660

Query: 661  VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720
            VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
Sbjct: 661  VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720

Query: 721  HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
            HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA
Sbjct: 721  HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780

Query: 781  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
            ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE
Sbjct: 781  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840

Query: 841  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
            ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
Sbjct: 841  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900

Query: 901  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960
            SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA
Sbjct: 901  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960

Query: 961  LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020
            LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR
Sbjct: 961  LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020

Query: 1021 SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1080
            SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE
Sbjct: 1021 SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1080

Query: 1081 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1116
            RDNAELQEFANAILQQIADHCPDILEQVVNALEESS
Sbjct: 1081 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1116


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 2066 bits (5353), Expect = 0.0
 Identities = 1088/1116 (97%), Positives = 1088/1116 (97%), Gaps = 28/1116 (2%)

Query: 1    MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
            MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ
Sbjct: 1    MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60

Query: 61   SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120
            SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS
Sbjct: 61   SLNAAYATSGPMYLSDHENVGSETPKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVAS 120

Query: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
            DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS
Sbjct: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180

Query: 181  SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
            SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR
Sbjct: 181  SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240

Query: 241  DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
            DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ
Sbjct: 241  DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300

Query: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360
            TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML
Sbjct: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSML 360

Query: 361  REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
            REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE
Sbjct: 361  REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDT 480
            EEMKQMEVYRSHSKFMKNK                            IGQVKQELSRKDT
Sbjct: 421  EEMKQMEVYRSHSKFMKNK----------------------------IGQVKQELSRKDT 452

Query: 481  ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 540
            ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK
Sbjct: 453  ELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNK 512

Query: 541  KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 600
            KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER
Sbjct: 513  KTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572

Query: 601  VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 660
            VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK
Sbjct: 573  VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEK 632

Query: 661  VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 720
            VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA
Sbjct: 633  VSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA 692

Query: 721  HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
            HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA
Sbjct: 693  HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 752

Query: 781  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
            ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE
Sbjct: 753  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 812

Query: 841  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
            ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ
Sbjct: 813  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 872

Query: 901  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 960
            SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA
Sbjct: 873  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAA 932

Query: 961  LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 1020
            LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR
Sbjct: 933  LKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNR 992

Query: 1021 SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1080
            SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE
Sbjct: 993  SKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1052

Query: 1081 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1116
            RDNAELQEFANAILQQIADHCPDILEQVVNALEESS
Sbjct: 1053 RDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1088


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 1189 bits (3076), Expect = 0.0
 Identities = 652/1031 (63%), Positives = 794/1031 (77%), Gaps = 105/1031 (10%)

Query: 1    MYGSARSVGKVEPSSQSPGRSPRLPRSPRLGHRRTNSTGGSSGSSVGGGSGKTLSMENIQ 60
            MYGSAR++  +E S   P RSPRLPRSPRLGHRRT+S GG       GG+GKTLSMENIQ
Sbjct: 1    MYGSARTITNLEGS---PSRSPRLPRSPRLGHRRTSSGGG-------GGTGKTLSMENIQ 50

Query: 61   SLNAAYATSGPMYLSDHENVGSET-PKSTMTLGRSGGRLPYGVRMTAMGSSPNIASSGVA 119
            SLNAAYATSGPMYLSDHE V S T PK TMTLGR+  R  YG R+TAMGSSPNIAS+G++
Sbjct: 51   SLNAAYATSGPMYLSDHEGVASTTYPKGTMTLGRATNRAVYGGRVTAMGSSPNIASAGLS 110

Query: 120  -SDTIAFGEHHLPPVSMAS----TVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
             +D +++ + H      +      VP  LRQ RD+T++DLQ QLKE+ RENDLLRK++++
Sbjct: 111  HTDVLSYTDQHGGLTGSSHHHHHQVPSMLRQVRDSTMLDLQAQLKELQRENDLLRKELDI 170

Query: 175  KESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQD 234
            K+SKL SSMNSIKTFWSPELKKER LRK+EA+++++ KEQ RV  EENQH+Q+TIQALQD
Sbjct: 171  KDSKLGSSMNSIKTFWSPELKKERVLRKEEAARMSVLKEQMRVSHEENQHLQLTIQALQD 230

Query: 235  ELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR 294
            ELR QRDLN L QQ+S +R  E    ELTEENF+RL AEH+RQAKELFLLRKTLEEMELR
Sbjct: 231  ELRTQRDLNHLLQQESGNRGAEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELR 290

Query: 295  IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKE 354
            IETQKQTLNARDESIKKLLEMLQSKGL +K+ E+D+ERTRR+AEAE  V HLE +L+QKE
Sbjct: 291  IETQKQTLNARDESIKKLLEMLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKE 350

Query: 355  KENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
            KEN  LREE+HRR +  P+ AKTKALQTVIEMKD+KI+S+ER +RDLE+EIQMLK+NG L
Sbjct: 351  KENIHLREELHRRSQLQPEPAKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVL 410

Query: 415  STEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE 474
            +TE+REEE+KQ+EVY+SHSKFMK K++QLK+ELS KE                       
Sbjct: 411  NTEDREEEIKQIEVYKSHSKFMKTKIDQLKQELSKKE----------------------- 447

Query: 475  LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
                 +ELLALQTKLETL+NQ SD KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK
Sbjct: 448  -----SELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 502

Query: 535  ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
            E+ LNKKTKQ+QD+ EEKGT AGEI D+KDML+VKERK+NVLQKKIENLQEQLRDK+KQ+
Sbjct: 503  ESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQL 562

Query: 595  SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDL 654
            ++LK+RVKSLQ D++NTDTAL TLEEAL+EKER IERLKEQR+RD+RE+ EEI++++K+ 
Sbjct: 563  TNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKEN 622

Query: 655  KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714
            KDLKEKV+ LQ +L+EKE+SL+DLKEHASSLAS+GLK+DS+LK+LEIA+EQKKEEC K+E
Sbjct: 623  KDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKLE 682

Query: 715  SQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND 774
            +QLKKAH    ++R +PE +D+I+ L++E + Y+DE  KAQAEVDRLLEILKEVENEKND
Sbjct: 683  AQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKND 742

Query: 775  KDKKIAELE----RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
            KDKKIAELE    R +KDQNKKVANLKH +Q+EKKK+AQ+LEE RRRED++ D+SQ LQ 
Sbjct: 743  KDKKIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQ- 801

Query: 831  SLRKKDDRIEELEEALRESVQ-ITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
                    IEEL  AL ++ Q + A +  + + ++S    AEK+     + +E+ KQ  E
Sbjct: 802  --------IEELMNALEKTRQELDATKARLASTQQSL---AEKEAHLANLRIERRKQLEE 850

Query: 890  SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSS 949
             ++ K  +   +++EK+ ++             +LE+                     +S
Sbjct: 851  ILEMKQEALLAAISEKDANIA------------LLELS--------------------AS 878

Query: 950  SKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH------------S 997
             KKKTQEEV ALKREKDRLV QLKQQTQNRMKLMADNY+DDH    H            S
Sbjct: 879  KKKKTQEEVMALKREKDRLVHQLKQQTQNRMKLMADNYDDDHHHYHHHHHHHHHRSPGRS 938

Query: 998  NQTNHKPSPDQ 1008
              +NH+PSPDQ
Sbjct: 939  QHSNHRPSPDQ 949



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 102/529 (19%), Positives = 228/529 (43%), Gaps = 50/529 (9%)

Query: 582  NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641
            +LQ QL++ +++   L++ +    +   ++  ++ T      +KER + +          
Sbjct: 149  DLQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK---------- 198

Query: 642  EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI 701
            E+   +   K+ ++   E+   LQ  +   +  L   ++    L      + +   T+E+
Sbjct: 199  EEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQRDLNHLLQQESGNRGAEHFTIEL 258

Query: 702  ALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
              E  +   L+ E   ++A E  L  +   EM  RI+  +++    +DES K   E+ + 
Sbjct: 259  TEENFRR--LQAEHD-RQAKELFLLRKTLEEMELRIE-TQKQTLNARDESIKKLLEMLQS 314

Query: 762  LEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNL 821
              +  +   + N++ +++AE E QV    + + + K KE +  +      EE  RR    
Sbjct: 315  KGLPSKSLEDDNERTRRMAEAESQVSHL-EVILDQKEKENIHLR------EELHRRSQLQ 367

Query: 822  ND--SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 879
             +   ++ LQ  +  KD +I  LE  +R+   +  E +M+ A       + E++++++  
Sbjct: 368  PEPAKTKALQTVIEMKDTKIASLERNIRD---LEDEIQMLKANGVLNTEDREEEIKQI-- 422

Query: 880  AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQ--EALLAAISE 937
              E  K   + MK K+   +Q L++KE+ L  L+ +      +  + KQ  E L  +++ 
Sbjct: 423  --EVYKSHSKFMKTKIDQLKQELSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTA 480

Query: 938  KDANIALLELSSSKKKTQ-EEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 996
            K+   A+L+      + + EE  +   +K + +Q L ++       + D  +    K   
Sbjct: 481  KEQRAAILQTEVDALRLRLEEKESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERK 540

Query: 997  SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDD 1056
             N    K   + + + L + D+  + LK  +  L T   + D  +           L++ 
Sbjct: 541  INVLQKKI--ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALA---------TLEEA 589

Query: 1057 QAAWENELQKMTRGQLQD------ELEKGERDNAELQEFANAILQQIAD 1099
             +  E  ++++   + +D      E+E   ++N +L+E  NA+  ++ +
Sbjct: 590  LSEKERIIERLKEQRERDDRERLEEIESFRKENKDLKEKVNALQAELTE 638


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  171 bits (433), Expect = 4e-42
 Identities = 204/903 (22%), Positives = 399/903 (44%), Gaps = 104/903 (11%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP---------ELKKERALR 201
            + DLQ QL +   E           ES+L     ++ +  S          E + ER L 
Sbjct: 1287 LQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELL 1346

Query: 202  KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAE 261
            +     +T   E  +    E +        L+++LR  R   +L  ++  S       A+
Sbjct: 1347 QAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER---AQ 1403

Query: 262  LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET---QKQTLNARDESIKKLLEMLQS 318
              +E  +   A+ +   + L LL +TL E E  +ET   Q Q L  + E  K  LE+L S
Sbjct: 1404 ALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELL-S 1462

Query: 319  KGLSAKATEED--HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
              L  +  E D   E+ + L +    + HL   ++++E++ ++ RE++ R  E   ++ +
Sbjct: 1463 LDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQI-RELEKDRETQR 1521

Query: 377  TKALQTVIEM--KDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK---------- 424
                  ++E+  KD  I S    ++DL++++  L+   AL  EE   +M+          
Sbjct: 1522 NVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL-ALELEENHHKMECQQKLIKELE 1580

Query: 425  -QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
             Q E  R     +   +E+  +EL ++ +Q  +L+  +  L  E+ +  QE+  +  ++ 
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640

Query: 484  ALQTKLETLTNQFSDSKQHIEVLKESLTAKE----QRAAILQTEVDALRLRLEEKETMLN 539
             LQ + E LT       Q + + KE +   E    ++  IL+ +++ ++L L E+   L 
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELT 1700

Query: 540  KKTKQIQDMAEE-KG---TQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595
             + + +Q+ AEE KG    Q G +  +K +L  KE++V   Q+ I  LQE     E+Q+ 
Sbjct: 1701 TQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQ 1760

Query: 596  SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
             L  +V         T   L+  E+ +   ++ ++  +EQ +  E+  Q ++D  ++ L 
Sbjct: 1761 GLHRKVGE-------TSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALA 1813

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715
               +++  LQ +  + +     +KE A +L  +  +    LK     L+  KE+  ++E 
Sbjct: 1814 QRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEE 1873

Query: 716  QL--------------------KKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755
            +L                     +  E AL A    + +++ Q  E E    +D   +AQ
Sbjct: 1874 ELAVEGRRVQALEEVLGDLRAESREQEKALLA-LQQQCAEQAQEHEVETRALQDSWLQAQ 1932

Query: 756  A---EVDRLLEILK-EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ--VEKKKSAQ 809
            A   E D+ LE L+ E ++ ++ ++   A  E   +   K  A L+ KEQ  +E+ + ++
Sbjct: 1933 AVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSR 1992

Query: 810  MLE---------------EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALR---ESVQ 851
             LE                +R+ E+ L     ++QD   +  + +++L++AL    E ++
Sbjct: 1993 SLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELR 2052

Query: 852  ITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN 911
               ERE +L +  + R       E+  +  E+ ++E+  +   +   Q +LA+KE  +  
Sbjct: 2053 HQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILE 2112

Query: 912  LRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEV----AALKREKDR 967
            LR  ++++  E L    +   + + E+      L+L S + + Q E+    AAL++ + R
Sbjct: 2113 LRETQQRNNLEALPHSHKT--SPMEEQS-----LKLDSLEPRLQRELERLQAALRQTEAR 2165

Query: 968  LVQ 970
             ++
Sbjct: 2166 EIE 2168



 Score =  125 bits (315), Expect = 2e-28
 Identities = 192/889 (21%), Positives = 366/889 (41%), Gaps = 114/889 (12%)

Query: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS 180
            D+  F +        A T+  S+   R   + DL+ QL       +LL++  +  E +  
Sbjct: 372  DSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGK 431

Query: 181  SSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR 240
            +    ++   + E         D   ++    ++  ++Q+  + ++  ++ L+ E    R
Sbjct: 432  ALRQRLQKL-TGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLR 490

Query: 241  DLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQ 300
             +N   Q    S  G+       EE  + LH             R+ L+EM + +E ++ 
Sbjct: 491  RVNVELQLQGDSAQGQK------EEQQEELHLAVRE--------RERLQEMLMGLEAKQS 536

Query: 301  TLNARDESIKKLL---EMLQSKGLSAKAT-EEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
                  ES+ +L+   E L+S  L  +   +E  E T  LA AE      +S+ E    E
Sbjct: 537  ------ESLSELITLREALESSHLEGELLRQEQTEVTAALARAE------QSIAELSSSE 584

Query: 357  NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALST 416
            N++  E    R      SA  +AL         K+  + + L  LEEE Q + S      
Sbjct: 585  NTLKTEVADLRAAAVKLSALNEALAL------DKVG-LNQQLLQLEEENQSVCSR----M 633

Query: 417  EEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS 476
            E  E+    ++V  + ++    + E L E+ +  EAQ ++ ++  A LQA++  +++E  
Sbjct: 634  EAAEQARNALQVDLAEAE---KRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKE 690

Query: 477  RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 536
                +L   + + E  T Q     Q  +  +E L    Q    L  E  AL +RL+  E 
Sbjct: 691  EIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVER 750

Query: 537  MLNKKTKQIQDMAE----------EKGTQAGEIHDLKDMLDVKERKV----NVLQKKIEN 582
                  +Q+Q ++           E   Q   I   K  L+V+ + V     V+Q ++  
Sbjct: 751  DRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRC 810

Query: 583  LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDERE 642
            L+ +L  +  Q    +ER  + +          T LE+  A  E+ + +L+E+ +++   
Sbjct: 811  LKLELDTERSQAE--QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSW 868

Query: 643  KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL---KEHASSLASSGL------KKD 693
             Q+E+    K L+ L+ +   L+  L E++  +  +   +E   + A S L       + 
Sbjct: 869  HQQEL---AKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEK 925

Query: 694  SRLKTLEIALEQKKE--------ECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
             R+  LE  L+ +KE        E L+ + +++K  E         ++ +  + L+    
Sbjct: 926  ERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAAR 985

Query: 746  RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 805
            +++D+ +  Q E   LL+       +K D  K++ +L+ Q+  Q+     L  +E  EK 
Sbjct: 986  QHRDDLAALQEESSSLLQ-------DKMDLQKQVEDLKSQLVAQDDS-QRLVEQEVQEKL 1037

Query: 806  KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEES 865
            +  Q   E  R +  L      L  SL +K+ R+  L+EA           + +  QE S
Sbjct: 1038 RETQ---EYNRIQKELEREKASLTLSLMEKEQRLLVLQEA-----------DSIRQQELS 1083

Query: 866  ARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
            A          L   M++ + E + + A++   +Q + EKE       A+  + L E   
Sbjct: 1084 A----------LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEEL-EASH 1132

Query: 926  MKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 974
            + ++ L A++  ++A  A L+L     ++Q E  A +++     Q   Q
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181



 Score =  122 bits (305), Expect = 2e-27
 Identities = 184/891 (20%), Positives = 386/891 (43%), Gaps = 130/891 (14%)

Query: 150  TIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKIT 209
            T++  Q +L +  ++ + LR+D++V++ K   +   ++T    +L++ +   K+ A +  
Sbjct: 933  TLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQT----QLQEAQRELKEAARQ-- 986

Query: 210  IWKEQYRVVQEENQHMQMTIQALQDELRIQRDL----NQLFQQDSSSRTGEPCVAELTEE 265
              ++    +QEE+  +      LQD++ +Q+ +    +QL  QD S R  E  V E   E
Sbjct: 987  -HRDDLAALQEESSSL------LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039

Query: 266  N--FQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS----- 318
               + R+  E ER+   L L   +L E E R+   ++  + R + +  L + +Q      
Sbjct: 1040 TQEYNRIQKELEREKASLTL---SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQ 1096

Query: 319  KGLSAKAT------------------------EEDHERTRRL-----------AEAEMHV 343
            K LSA+                          E  H   ++L           A+ ++ +
Sbjct: 1097 KELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRL 1156

Query: 344  HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMK-------DSKISSM-- 394
               ES LE    E     +   +    +  SA  +AL +V E +       DS  S    
Sbjct: 1157 RSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGL 1216

Query: 395  ---ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK--FMKNKVEQLKEELSS 449
               + G R L +   +L +  A +      ++ Q +++++      ++++V++L+E L+ 
Sbjct: 1217 EPDQNGARSLFKRGPLLTALSAEAVASALHKLHQ-DLWKTQQTRDVLRDQVQKLEERLTD 1275

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             EA+  ++  +   LQ ++ Q ++E S+ + +  +L+++L  L    +           S
Sbjct: 1276 TEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA-----------S 1324

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L ++ +RA + + E    R  L+  +  L  + + +Q    E   QA     L++ L   
Sbjct: 1325 LQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
               + +  +++E+ +E+ +  ++Q      + K+LQ +       L  L + LAE+E  +
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQEN-------LALLTQTLAEREEEV 1437

Query: 630  ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689
            E L+ Q    E EKQ E+     +L  L  K    + DL +++  + +L++  S L    
Sbjct: 1438 ETLRGQIQ--ELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ--IQELEKCRSVLEHLP 1493

Query: 690  LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSD----RIQHLEREIT 745
            +    R + L +  EQ +E     E+Q        LE     +M +    ++Q L++++ 
Sbjct: 1494 MAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV 1553

Query: 746  RYKD---ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
              +    E  +   +++   +++KE+E ++  +   +  L   ++++++++     +   
Sbjct: 1554 TLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHD 1613

Query: 803  EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 862
             +  S  +  E + R+  +    +Q+++  R+K+   ++LE   +E + +  ER  VL  
Sbjct: 1614 LESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE-LMLQKERIQVL-- 1670

Query: 863  EESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEE 922
             E  RT   K +EE L   E++K  L     +L++ +Q + E        RAE  K   +
Sbjct: 1671 -EDQRTRQTKILEEDL---EQIKLSLRERGRELTTQRQLMQE--------RAEEGKGPSK 1718

Query: 923  VLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLK 973
                  E +   + +K+  +            QE +  L+  KD+L QQL+
Sbjct: 1719 AQRGSLEHMKLILRDKEKEVEC---------QQEHIHELQELKDQLEQQLQ 1760



 Score =  117 bits (293), Expect = 6e-26
 Identities = 208/961 (21%), Positives = 417/961 (43%), Gaps = 144/961 (14%)

Query: 198  RALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRD-LNQLFQQDSSSRTGE 256
            +ALR+D       W      +  +    QM  +  +  L+ +   L  L+++  + R   
Sbjct: 132  KALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHF 191

Query: 257  PCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEML 316
              +   T+ +   L AEH R       L  +L    LR+    Q+            E  
Sbjct: 192  LEMKSATDRDLMELKAEHVR-------LSGSLLTCCLRLTVGAQSREPNGSGRMDGREPA 244

Query: 317  QSKGLSAKATE---EDHERTRRL-----------AEAEMHVHHLESLLEQKEKENSMLRE 362
            Q   L AK  E   E HER++ L           AE +  V  L +LL Q +K+N    E
Sbjct: 245  QLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDY-E 303

Query: 363  EMHRRFENAPDSAKTKALQTVIEMKDSKIS--------SMERGLRDL-----EEEIQMLK 409
            +M +      +  +T    T +   ++ +S        S+++ ++D+     EE   + +
Sbjct: 304  KMIKALRETVEILETN--HTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361

Query: 410  SNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIG 469
             +G  ++ E +  +     Y+   K +      ++  L+ +    ++L+++ AG Q  + 
Sbjct: 362  GSGHENSLELDSSIFSQFDYQDADKALT----LVRSVLTRRRQAVQDLRQQLAGCQEAVN 417

Query: 470  QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 529
             ++Q+  + + E  AL+ +L+ LT +           +++L  +      LQ EVD+L  
Sbjct: 418  LLQQQHDQWEEEGKALRQRLQKLTGE-----------RDTLAGQ---TVDLQGEVDSLS- 462

Query: 530  RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 589
              +E+E +L K  ++++   E    +A  +  +   L ++       Q + E  QE+L  
Sbjct: 463  --KERE-LLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSA---QGQKEEQQEELHL 516

Query: 590  KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 649
              ++   L+E +  L+A  + + + L TL EAL       E L+++    + E    +  
Sbjct: 517  AVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQE----QTEVTAALAR 572

Query: 650  YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
             ++ + +L    + L+ ++++  A+ + L     +LA   +  + +L  LE   E+ +  
Sbjct: 573  AEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLE---EENQSV 629

Query: 710  CLKMES--QLKKAHEAAL-EARASPE-MSDRIQHLEREITRYKDESSKAQAEVDRLLEIL 765
            C +ME+  Q + A +  L EA    E + ++  HLE ++ + ++  ++ QA+       L
Sbjct: 630  CSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQAD-------L 682

Query: 766  KEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS 825
            ++++ EK +  KK++E   Q   Q      L+   Q E K+  ++L  A + ++ L    
Sbjct: 683  RDIQEEKEEIQKKLSESRHQ---QEAATTQLEQLHQ-EAKRQEEVLARAVQEKEALVREK 738

Query: 826  QQLQDSLRKKDDRIEELEEALR--ESVQITAEREMVLAQEESA-----RTNAEKQVEELL 878
              L+  L+  +   ++L E L+   S +   E  +  AQ++++     +   E Q++ + 
Sbjct: 739  AALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVT 798

Query: 879  MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR-AERRKHLEEVLEMKQEALLAAISE 937
             A E ++ E+  +K +L  T++S AE+E      + A+  +  +  LE ++ A      E
Sbjct: 799  QAKEVIQGEVRCLKLELD-TERSQAEQERDAAARQLAQAEQEGKTALEQQKAA-----HE 852

Query: 938  KDANIALLELSSSKKKTQEEVA----ALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFK 993
            K+ N    +    +   Q+E+A    +L+REK  L  +LK+Q Q  M+ +    E++  +
Sbjct: 853  KEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQ-QTEMEAIQAQREEERTQ 911

Query: 994  SSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNL 1053
            +  +           + Q  LE ++ R  L      L TL   +  L        AS  L
Sbjct: 912  AESA-----------LCQMQLETEKERVSL------LETLLQTQKEL------ADASQQL 948

Query: 1054 DDDQAAWENELQKM----TRGQLQDELEKGER-----------DNAELQEFANAILQQIA 1098
              ++   + ++QK+    T G LQ +L++ +R           D A LQE ++++LQ   
Sbjct: 949  --ERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 1099 D 1099
            D
Sbjct: 1007 D 1007



 Score =  116 bits (291), Expect = 1e-25
 Identities = 187/918 (20%), Positives = 394/918 (42%), Gaps = 147/918 (16%)

Query: 156  TQLKEVLR--------ENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
            TQ KEV++        E D  R   E +    +  +   +      L++++A  + E ++
Sbjct: 798  TQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQ 857

Query: 208  ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
            +   +E++   +E + H Q   +AL+    ++R+  +L  +    +T    +    EE  
Sbjct: 858  L---REKWE--KERSWHQQELAKALES---LEREKMELEMRLKEQQTEMEAIQAQREE-- 907

Query: 268  QRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327
            +R  AE      +L   ++ +  +E  ++TQK+  +A  + +++L + ++ + L  + T 
Sbjct: 908  ERTQAESALCQMQLETEKERVSLLETLLQTQKELADA-SQQLERLRQDMKVQKLKEQETT 966

Query: 328  -----EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382
                 +  E  R L EA     H + L   +E+ +S+L+++M  + +     ++  A   
Sbjct: 967  GILQTQLQEAQRELKEAARQ--HRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024

Query: 383  VIEMKDSKISSMERGLRD---LEEEIQMLKSNGALSTEEREEEMKQME----VYRSHSKF 435
               + + ++    R  ++   +++E++  K++  LS  E+E+ +  ++    + +     
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSA 1084

Query: 436  MKNKVEQLKEELSSKEAQWE----ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL-- 489
            ++  +++ + E     AQ E    E+K+K A   A+  Q+ +EL         L+  L  
Sbjct: 1085 LRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWA 1144

Query: 490  -ETLTNQFSDSKQHIEVLKESLTAKEQ--RAAILQTEVDALRLRLEEKETMLNKKTKQIQ 546
             E    Q     +  E   E+L A++Q    A  Q ++ +L   L++    + +   ++ 
Sbjct: 1145 QEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELS 1204

Query: 547  ---DMA--------EEKGTQ-----------------AGEIHDLKDMLDVKERKVNVLQK 578
               D A        ++ G +                 A  +H L   L   ++  +VL+ 
Sbjct: 1205 GGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRD 1264

Query: 579  KIENLQEQLRDKE--------------KQMSSLKERVKSLQADTTNTDTALTTLEEALAE 624
            +++ L+E+L D E              +Q+S  +E     +    + ++ L  L E +A 
Sbjct: 1265 QVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMAS 1324

Query: 625  KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE--KEASLLDLKEHA 682
             +  + R + QR     E Q E +  +   ++L  +V  LQ  + E   +AS   + E  
Sbjct: 1325 LQSRLRRAELQR----MEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEED 1380

Query: 683  SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 742
               A S LK    LK  E+  E+++ + L+ + +LK A   A               L+ 
Sbjct: 1381 LRTARSALK----LKNEEVESERERAQALQEQGELKVAQGKA---------------LQE 1421

Query: 743  EITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV 802
             +       ++ + EV+ L   ++E+E ++  +   +  L   +K +N++V     +EQ+
Sbjct: 1422 NLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVD--LQQEQI 1479

Query: 803  EKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ 862
                  Q LE+ R   ++L  + Q+ +  L  + ++I ELE+  RE+ +   E +++  +
Sbjct: 1480 ------QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKD-RETQRNVLEHQLLELE 1532

Query: 863  EESARTNAEK-QVEEL---LMAMEKVKQELESMKAKLSSTQQSLAEKE----------TH 908
            ++     +++ QV++L   L+ +E +  ELE    K+   Q+ + E E          TH
Sbjct: 1533 KKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTH 1592

Query: 909  LTNLRAERRKHLE------EVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK 962
            LT    ER + L+        LE     L   + E+D  +         K  +E++  L+
Sbjct: 1593 LTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEV---------KSQREQIEELQ 1643

Query: 963  REKDRLVQQLKQQTQNRM 980
            R+K+ L Q L+++ Q  M
Sbjct: 1644 RQKEHLTQDLERRDQELM 1661



 Score =  114 bits (284), Expect = 7e-25
 Identities = 171/835 (20%), Positives = 354/835 (42%), Gaps = 124/835 (14%)

Query: 137  STVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK 196
            STV     Q RD  +   + Q++E+ R+ + L +D+E ++ +L      I+       ++
Sbjct: 1618 STVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQ 1677

Query: 197  ERALRKD-EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR---DLNQLFQQDSSS 252
             + L +D E  K+++ +E+ R +  + Q MQ   +  +   + QR   +  +L  +D   
Sbjct: 1678 TKILEEDLEQIKLSL-RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736

Query: 253  RTGEPC-------VAELTEENFQRLHAEHER----------QAKELFLLRKTLEEMELRI 295
                 C       + EL ++  Q+L   H +          + +E+ +L++ L+E   + 
Sbjct: 1737 EV--ECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794

Query: 296  ETQKQTLNAR-DESIKKL------LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
            E ++Q+L ++ DE+ + L      LE LQ +   A+  E   ER +  A+A      L+ 
Sbjct: 1795 ELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQE---ERVKEKADA------LQG 1845

Query: 349  LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDL------- 401
             LEQ      M  +E H   ++  + A  + L+  + ++  ++ ++E  L DL       
Sbjct: 1846 ALEQAH----MTLKERHGELQDHKEQA--RRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899

Query: 402  EEEIQMLKSNGALSTEEREEEMKQME----VYRSHSKFMKNKVEQLKEELSSKEAQWEEL 457
            E+ +  L+   A   +E E E + ++      ++  K    ++E L+ E  S   Q E  
Sbjct: 1900 EKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAA 1959

Query: 458  KKKAAGLQAEIGQVKQELSRKDTELL-------ALQTKLETLTNQFSDSKQHIEVLKESL 510
            + +A  LQ  +G+    L  K+  LL       +L+    TL       + H   L+E+L
Sbjct: 1960 RARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019

Query: 511  TAKE----QRAAILQTEVDALRLRLEEKETML--NKKTKQIQDMAEEKGTQAGEIHDLKD 564
              +E     +    Q +V  L+  L +++  L   ++ +Q+ + +  +  Q   I + ++
Sbjct: 2020 RIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQN 2079

Query: 565  M-LDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALA 623
            +  + +E ++  L + +  LQ  L  KE+++  L+E  +    +        + +E    
Sbjct: 2080 LGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPME---- 2135

Query: 624  EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 683
            E+   ++ L+ +  R+    Q  +   +    + +EK   L   L++ +AS+  L+E A 
Sbjct: 2136 EQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAM 2195

Query: 684  SLASSGLKKDSRLKTLEIALEQKKEECLKM-----------------ESQLKKAHEAALE 726
             L +S L++DS  + L+  LE  +    K                  E  ++    + +E
Sbjct: 2196 FLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVE 2255

Query: 727  ARASPE------MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN------- 773
            A  SP+         R++HL++ + R + + S+ Q    +L   L++VE E+        
Sbjct: 2256 AEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAM 2315

Query: 774  --------DKDKKIAELERQVKDQNKKVANLKHKEQVEKK---KSAQMLEEARRREDNLN 822
                    +  K  A    Q   + +K ++ K   +++K+     AQ+  E ++++D + 
Sbjct: 2316 RAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYIT 2375

Query: 823  DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
             S+Q  ++        +  L  +L  S+   A+       E   R   E   + L
Sbjct: 2376 RSAQTSRE--------LAGLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQSL 2422



 Score =  100 bits (249), Expect = 8e-21
 Identities = 165/862 (19%), Positives = 345/862 (40%), Gaps = 155/862 (17%)

Query: 259  VAELTEENFQRLHAEHERQAKELFLLRKT----------LEEMELRIETQKQTLNARDES 308
            +AE    ++++L    E Q ++  L+RK            +E+E R+E     +  R E+
Sbjct: 31   MAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEATGGPIPQRWEN 90

Query: 309  IKK--LLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR 366
            +++  L E+L          EE+ +R   LAE       L   +E+ +  N  LRE++ +
Sbjct: 91   VEEPNLDELLVR-------LEEEQQRCESLAEVNTQ---LRLHMEKADVVNKALREDVEK 140

Query: 367  R---FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEM 423
                +  A D    K  Q  +E +  K                +   +G L +  RE   
Sbjct: 141  LTVDWSRARDELMRKESQWQMEQEFFKG--------------YLKGEHGRLLSLWRE--- 183

Query: 424  KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS------- 476
              +  +R H   MK+  ++   EL ++  +          L+  +G   +E +       
Sbjct: 184  --VVTFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTCC-LRLTVGAQSREPNGSGRMDG 240

Query: 477  RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 536
            R+  +LL L  K + L  +  +  Q +  LK     ++       TE+ AL  + +++  
Sbjct: 241  REPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNE 300

Query: 537  MLNKKTKQIQDMAEEKGTQAGEI--HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQM 594
               K  K +++  E   T   E+  H+     + +E K++ LQ+ I+++ + + ++   +
Sbjct: 301  DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLS-LQQVIKDITQVMVEEGDNI 359

Query: 595  SSLKERVKSLQADTT--------NTDTALTTLEEALAEKERTIERLKEQRDRDEREK--- 643
            +       SL+ D++        + D ALT +   L  + + ++ L++Q    +      
Sbjct: 360  AQGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLL 419

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            Q++ D ++++ K L++++  L G+        +DL+    SL+          + L   L
Sbjct: 420  QQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQL 479

Query: 704  EQKKEECLKM------------------ESQLKKAHEAA------------LEARASPEM 733
            E  ++E  ++                  E Q ++ H A             LEA+ S  +
Sbjct: 480  EVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL 539

Query: 734  SDRI--------QHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELER- 784
            S+ I         HLE E+ R   E ++  A + R  + + E+ + +N    ++A+L   
Sbjct: 540  SELITLREALESSHLEGELLR--QEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597

Query: 785  -----------------------QVKDQNKKVAN-LKHKEQVEKKKSAQMLEEARRRE-- 818
                                   Q++++N+ V + ++  EQ        + E  +RRE  
Sbjct: 598  AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREAL 657

Query: 819  -----------DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
                           ++  +LQ  LR   +  EE+++ L ES     ++E    Q E   
Sbjct: 658  WEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSES---RHQQEAATTQLEQLH 714

Query: 868  TNAEKQVEELLMAM---EKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVL 924
              A++Q E L  A+   E + +E  +++ +L + ++   +    L  L + +      + 
Sbjct: 715  QEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLF 774

Query: 925  EMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA 984
            E +Q+  +  +++    + +  ++ +K+  Q EV  LK E D    Q +Q+     + +A
Sbjct: 775  EAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLA 834

Query: 985  DNYED-----DHFKSSHSNQTN 1001
               ++     +  K++H  + N
Sbjct: 835  QAEQEGKTALEQQKAAHEKEVN 856



 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 113/621 (18%), Positives = 251/621 (40%), Gaps = 86/621 (13%)

Query: 519  ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH-----------DLKDMLD 567
            +L+ +V AL+ ++ E +    +K K  Q+  + + T   ++            +L+  L+
Sbjct: 19   VLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLE 78

Query: 568  -----VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
                 + +R  NV +  ++ L  +L +++++  SL E    L+      D     L E +
Sbjct: 79   ATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKALREDV 138

Query: 623  AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD--------LKEKVSLLQGDLSEKEAS 674
             +      R +++  R E + Q E + +K  LK          +E V+  +  L  K A+
Sbjct: 139  EKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRRHFLEMKSAT 198

Query: 675  LLDLKE-HASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEM 733
              DL E  A  +  SG      L+    A  ++     +M+   ++  +  L    + E+
Sbjct: 199  DRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDG--REPAQLLLLLAKTQEL 256

Query: 734  SDRIQHLEREITRYKDESSKAQAEV-DRLLEILKEVENEKNDKDKKIAELERQVKDQNKK 792
                    +E+ + K +    +AE+ DR+ E+              + + ++Q +D  K 
Sbjct: 257  EKEAHERSQELIQLKSQGDLEKAELQDRVTEL-----------SALLTQSQKQNEDYEKM 305

Query: 793  VANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 852
            +  L+   ++ +    +++E     E +L+ ++Q+ + SL++    I ++     +++  
Sbjct: 306  IKALRETVEILETNHTELMEH----EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361

Query: 853  TAEREMVLAQEESART-----NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKET 907
             +  E  L  + S  +     +A+K +  +   + + +Q ++ ++ +L+  Q+++     
Sbjct: 362  GSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAV----- 416

Query: 908  HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIA-LLELSSSKKKTQEEVAALKREKD 966
               NL  ++    EE  +  ++ L     E+D      ++L        +E   L++ ++
Sbjct: 417  ---NLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKARE 473

Query: 967  RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLY 1026
             L QQL+   Q   +L   N E      S   Q                 ++ + +L   
Sbjct: 474  ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQK----------------EEQQEEL--- 514

Query: 1027 IGHLTTLCHDRDPLILRGLTPPASYNLDD--------DQAAWENELQKMTRGQLQDELEK 1078
              HL     +R   +L GL    S +L +        + +  E EL +  + ++   L +
Sbjct: 515  --HLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALAR 572

Query: 1079 GERDNAELQEFANAILQQIAD 1099
             E+  AEL    N +  ++AD
Sbjct: 573  AEQSIAELSSSENTLKTEVAD 593


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score =  165 bits (417), Expect = 3e-40
 Identities = 219/1009 (21%), Positives = 436/1009 (43%), Gaps = 140/1009 (13%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKTFWSPELKK-ERALRKDEASK 207
            + DLQ  LKE    ++ L+K++E  +   +  +  + + T  S EL+  E+ L + +   
Sbjct: 92   VQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTEN 151

Query: 208  ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE-----PCVAEL 262
              I K+   + +++   +   I  ++ +   +R L +  +Q  +  T E       + +L
Sbjct: 152  FNI-KQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDL 210

Query: 263  TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
              E  QR   E      ++ +L+K L +++  ++          E +K   + LQS+  S
Sbjct: 211  KTELLQRPGIE------DVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYAS 264

Query: 323  AKAT--EEDHERTRRLAEAEMHVHHLESL------LEQKEK---ENSMLREEMHRRFE-- 369
            ++AT  +   E  +   E  ++V  L+ L      L QK +   EN + +E+ + + E  
Sbjct: 265  SEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEK 324

Query: 370  NAPDSAKTKALQTVIEMKD-------SKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
            +  +S   K +Q  +  KD       S++S+ E  L  +  E+    S    +T++ +EE
Sbjct: 325  HNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVEL----SEKGEATQKLKEE 380

Query: 423  MKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTEL 482
            + ++E           K + LK E    + Q EE ++    LQ+EI Q+  +L   + +L
Sbjct: 381  LSEVE----------TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL 430

Query: 483  LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET------ 536
                 +L          K+  ++  E L  KEQ+ A LQ ++  L  +L+EK T      
Sbjct: 431  GEAHGRL----------KEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQ 480

Query: 537  -MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595
              L+K  +Q Q+    + +   ++ + ++ L+   R++    +KI+NL+  L+  ++ +S
Sbjct: 481  HQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENIS 540

Query: 596  SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
             L++  + L A     +     L + L EK  T+              QE++    + LK
Sbjct: 541  LLEKEREDLYAKIQAGEGETAVLNQ-LQEKNHTL--------------QEQVTQLTEKLK 585

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715
            +  E     Q +L ++   + + K H  +     L  ++ +  L   L + KE+  +++ 
Sbjct: 586  NQSESHKQAQENLHDQ---VQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDI 642

Query: 716  QLKKAHEAALEARA--SPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKN 773
            Q+K   E  L A A  + + +D   HL+      +D+    Q E++++   L +V  +  
Sbjct: 643  QIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDK----QQELNKITTQLDQVTAKLQ 698

Query: 774  DKDKKIAELERQVKDQNKKVANLKHK-EQVE---KKKSAQMLEEARRREDNLNDSSQQLQ 829
            DK +  ++LE  +K+  +K  +L+ K E++E   KK  A  LE    +E  L D  QQ Q
Sbjct: 699  DKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQ 758

Query: 830  DS---------------------------LRKKDDRIEELEEAL---RESVQITAEREMV 859
             +                           L+KK + +E +++ L    E  QI  +    
Sbjct: 759  LNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFET 818

Query: 860  LAQEESAR-TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRK 918
            L+QE   +      +++  +  ++KVK E E++  +LS+ +  L++    L N ++E  K
Sbjct: 819  LSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878

Query: 919  HLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN 978
                    K +A +  + EK       +L    + T +E   LK+  ++     +++  +
Sbjct: 879  E-----NQKGKAAILDL-EKTCKELKHQLQVQMENTLKEQKELKKSLEK-----EKEASH 927

Query: 979  RMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1038
            ++KL  ++ ++   ++ ++ + N K    Q+   + EL Q+  + K  I     L  +  
Sbjct: 928  QLKLELNSMQEQLIQAQNTLKQNEK-EEQQLQGNINELKQSSEQKKKQI---EALQGELK 983

Query: 1039 PLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQ 1087
              +L+             QAA E   +K     LQ+  EK +    +LQ
Sbjct: 984  IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032



 Score =  156 bits (394), Expect = 1e-37
 Identities = 204/973 (20%), Positives = 429/973 (44%), Gaps = 121/973 (12%)

Query: 143  LRQARDNTIMDLQTQLKEVLREN---DLLRKDVEVKE--SKLSSSMNSIKTFWSPELKKE 197
            L++ +D T ++ +   + V ++N    L +KD++ ++  S+LS+S  S+        +K 
Sbjct: 312  LKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371

Query: 198  RALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDE--------LRIQRDLNQLFQQ- 248
             A +K         KE+   V+ + QH++   + LQ +        L++Q ++NQL  + 
Sbjct: 372  EATQK--------LKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKL 423

Query: 249  -DSSSRTGEPC--VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
             ++  + GE    + E  + + ++L  + ++ A     L +  E+++ ++    +  +  
Sbjct: 424  LETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQL 483

Query: 306  DESIKKLLE---MLQSKGLSAKATEEDHERT-RRLAEAEMHVHHLESLLEQKEKENSML- 360
            D++ ++  E   + QS     +  + D E+  R++ + +  + +LE+LL QK KEN  L 
Sbjct: 484  DKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALL-QKSKENISLL 542

Query: 361  ---REEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
               RE+++ + +             V+     K  +++  +  L E+   LK+      +
Sbjct: 543  EKEREDLYAKIQAGEGET------AVLNQLQEKNHTLQEQVTQLTEK---LKNQSESHKQ 593

Query: 418  EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
             +E    Q++  ++H +  +++V  L+  ++   +Q  E K+K + L  +I        +
Sbjct: 594  AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQI--------K 645

Query: 478  KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM 537
              TELL      +T   Q +D + H++  + +L  K+Q    + T++D +  +L++K+  
Sbjct: 646  AKTELLLSAEAAKTA--QRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEH 703

Query: 538  LNKKTKQIQDMAE-----EKGTQA--GEIHDLK-DMLDVKERKVNVLQ----KKIENLQE 585
             ++    +++  E     E+ T+   G+I  L+ D L+VK  K   LQ    ++  N   
Sbjct: 704  CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763

Query: 586  QLRDKE--KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK---EQRDRDE 640
            +LR  E  KQ+   KE V S + D      AL ++++ L ++E   + LK   E   ++ 
Sbjct: 764  ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823

Query: 641  REKQEEIDN-----------YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 689
            + + EE++N            K + + L  ++S ++  LS+   SL + K         G
Sbjct: 824  KIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKG 883

Query: 690  ----LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREIT 745
                L  +   K L+  L+ + E  LK + +LKK+ E   E  AS ++   +  ++ ++ 
Sbjct: 884  KAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK--EKEASHQLKLELNSMQEQLI 941

Query: 746  RYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKK 805
            + ++   + + E  +L   + E++     K K+I  L+ ++K    +   L++K Q +  
Sbjct: 942  QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001

Query: 806  KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI--TAEREMVLAQE 863
            ++AQ L   + +   L ++ ++ Q++ ++        E  L  + Q   + E ++ LAQE
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061

Query: 864  --------------------------ESARTNAEKQVEELLMAMEKVKQELESMKAKLSS 897
                                      E      E+Q++E   A++ +++E    + +L +
Sbjct: 1062 DLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVN 1121

Query: 898  TQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL----LELSSSKKK 953
             +  LAE E        E  K  EE+   K E++    + KDA   L    LEL      
Sbjct: 1122 EKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADS 1181

Query: 954  TQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDH--FKSSHSNQTNHKPSPDQIIQ 1011
             +  V   KR +  L  Q+K++ +   K   +     H   K        H+ +  ++  
Sbjct: 1182 LKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTM 1241

Query: 1012 PLLELDQNRSKLK 1024
             +  L++N   +K
Sbjct: 1242 QITALNENLGTVK 1254



 Score =  149 bits (375), Expect = 2e-35
 Identities = 199/933 (21%), Positives = 405/933 (43%), Gaps = 132/933 (14%)

Query: 127  EHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI 186
            +H L           +L+Q+    + + Q  L++VLR+     + ++  E+ L  S  +I
Sbjct: 480  QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539

Query: 187  KTFWSPELKKERALRKDEASKITIWKEQYRVV---QEENQHMQMTIQALQDELRIQRDLN 243
                   L+KER   +D  +KI   + +  V+   QE+N  +Q  +  L ++L+ Q + +
Sbjct: 540  SL-----LEKER---EDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591

Query: 244  QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLN 303
            +  Q++         + +  +E    L A  +R    +  L  ++ E+  ++   K+ ++
Sbjct: 592  KQAQEN---------LHDQVQEQKAHLRAAQDR----VLSLETSVNELNSQLNESKEKVS 638

Query: 304  ARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREE 363
              D  IK   E+L    LSA+A      +T + A+ + H+   ++ L+ K++E + +  +
Sbjct: 639  QLDIQIKAKTELL----LSAEAA-----KTAQRADLQNHLDTAQNALQDKQQELNKITTQ 689

Query: 364  MHRRFENAPDSAK-TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
            + +      D  +    L++ ++    K  S+E+   +LE +I+ L+++       +E+ 
Sbjct: 690  LDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749

Query: 423  MKQMEVYRSHSKFMKNKVEQLKEELSSKE----AQWEELKKKAAGLQAEIGQVKQELSRK 478
            ++ ++  R  +  ++ +  +L ++L  ++    +   +L+KK+  L++    +KQ+L+++
Sbjct: 750  LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES----IKQKLTKQ 805

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
            + E   L+   ETL+ +   +K   E L   +         ++ E +AL   L   +  L
Sbjct: 806  EEEKQILKQDFETLSQE---TKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKL 862

Query: 539  NKKTKQIQDMAEE--KGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 596
            +K +  +++   E  K  Q G+   L      KE K + LQ ++EN  ++ ++ +K +  
Sbjct: 863  SKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK-HQLQVQMENTLKEQKELKKSLEK 921

Query: 597  LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 656
             KE    L+ +       L +++E L + + T++    Q +++E++ Q  I+  K+  + 
Sbjct: 922  EKEASHQLKLE-------LNSMQEQLIQAQNTLK----QNEKEEQQLQGNINELKQSSEQ 970

Query: 657  LKEKVSLLQGDL------------------SEKEASLLDLKEHASSLASSGLKKDSRLKT 698
             K+++  LQG+L                  ++    L   KE  S L ++  K     K 
Sbjct: 971  KKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQ 1030

Query: 699  LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR---------IQHLEREITRYKD 749
            L+     ++ E L     LK   E  L       +S+R         IQ L+      + 
Sbjct: 1031 LQSDFYGRESELLATRQDLKSVEEK-LSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQ 1089

Query: 750  ESSKAQAEVDRLLEILKEVENEKNDKDK-------KIAELERQVKDQNKKVANLKHKEQV 802
            +S+K + ++    + L++++ EK+ K+K       K+AE+E     Q K++  L  + + 
Sbjct: 1090 DSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKS 1149

Query: 803  EKKKSAQMLEEARRREDNLNDSSQQLQ---DSLRK------------KDDRIEELEEALR 847
             K +S + +   +  +  L     +LQ   DSL+             KD   +E EE  +
Sbjct: 1150 HKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKK 1209

Query: 848  ESVQITA-------EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
            E ++  A       E+E+ + + E        Q+  L   +  VK+E +S + ++S  ++
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269

Query: 901  -------SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKK 953
                    +A  E  + N + ERR  LE  L  K E  +  +  K     +LEL      
Sbjct: 1270 QTDDLRGEIAVLEATVQNNQDERRALLERCL--KGEGEIEKLQTK-----VLELQRKLDN 1322

Query: 954  TQEEVAALKREKDRLVQQLKQQTQNRMKLMADN 986
            T   V  L RE   L  Q+K       K   DN
Sbjct: 1323 TTAAVQELGRENQSL--QIKHTQALNRKWAEDN 1353



 Score =  144 bits (362), Expect = 6e-34
 Identities = 182/785 (23%), Positives = 340/785 (43%), Gaps = 141/785 (17%)

Query: 233 QDELRIQRD----LNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTL 288
           +  L ++RD    L Q  Q   +S   E   +E  ++  ++     +++AK   L+  + 
Sbjct: 75  ESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSS 134

Query: 289 EEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLES 348
            E++  +E Q +     + +IK++ ++ + K     ATE        +A+ +       S
Sbjct: 135 AELQ-SLEQQLEEAQTENFNIKQMKDLFEQKAAQL-ATE--------IADIKSKYDEERS 184

Query: 349 LLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMER-GLRD---LEEE 404
           L E  E++ + L EE+++               TVI+  D K   ++R G+ D   L++E
Sbjct: 185 LREAAEQKVTRLTEELNKE-------------ATVIQ--DLKTELLQRPGIEDVAVLKKE 229

Query: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
           +  +++     T ERE E          S+ +K++ ++L+ + +S EA   +L+ + A  
Sbjct: 230 LVQVQTLMDNMTLERERE----------SEKLKDECKKLQSQYASSEATISQLRSELAKG 279

Query: 465 QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE-----SLTAKEQRAAI 519
             E+    QEL +  + +  L  K +TLT      +Q    L+E     S++ K  +A +
Sbjct: 280 PQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATL 339

Query: 520 LQTEVDALRL--RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 577
            Q ++D  +L  RL   ET L++   ++ +  E   TQ      LK+ L   E K   L+
Sbjct: 340 HQKDLDCQQLQSRLSASETSLHRIHVELSEKGE--ATQK-----LKEELSEVETKYQHLK 392

Query: 578 KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRD 637
            + + LQ+Q  +KE+    L+  +  L +    T       E  L E      RLKEQR 
Sbjct: 393 AEFKQLQQQREEKEQHGLQLQSEINQLHSKLLET-------ERQLGEAH---GRLKEQR- 441

Query: 638 RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLK 697
              +   E++ + ++ + DL+ K+S L+  L EK  +  +L+                  
Sbjct: 442 ---QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ---------------- 482

Query: 698 TLEIALEQKKEECLKMESQLKKAHEAALE----ARASPEMSDRIQHLEREITRYKDESSK 753
            L+   +Q +E+    +S   K  EA  +     R   +   +IQ+LE  + + K+  S 
Sbjct: 483 -LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISL 541

Query: 754 AQAEVDRLLEILKEVENEK---NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQM 810
            + E + L   ++  E E    N   +K   L+ QV    +K+     K Q E  K AQ 
Sbjct: 542 LEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKL-----KNQSESHKQAQ- 595

Query: 811 LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRE---------------SVQITAE 855
                   +NL+D  Q+ +  LR   DR+  LE ++ E                +QI A+
Sbjct: 596 --------ENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAK 647

Query: 856 REMVLAQE---ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL 912
            E++L+ E    + R + +  ++    A++  +QEL  +  +L      L +K+ H + L
Sbjct: 648 TELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707

Query: 913 RAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQL 972
            +  +++ E+ L ++Q+                EL    KK + +   +K  K++ +Q L
Sbjct: 708 ESHLKEYKEKYLSLEQKT--------------EELEGQIKKLEADSLEVKASKEQALQDL 753

Query: 973 KQQTQ 977
           +QQ Q
Sbjct: 754 QQQRQ 758



 Score = 80.9 bits (198), Expect = 6e-15
 Identities = 126/610 (20%), Positives = 267/610 (43%), Gaps = 98/610 (16%)

Query: 547  DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK---ERVKS 603
            +   + G  +G  H  +  L +K   V +L++++++LQ  L++++     LK   E+ + 
Sbjct: 61   EAVHDAGNDSG--HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG 118

Query: 604  LQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
            LQ      D  +T     L   E+ +E           E Q E  N K+ +KDL E+ + 
Sbjct: 119  LQQQEAKPDGLVTDSSAELQSLEQQLE-----------EAQTENFNIKQ-MKDLFEQKA- 165

Query: 664  LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEA 723
                L+ + A +    +   SL  +  +K +RL           EE  K  + ++     
Sbjct: 166  --AQLATEIADIKSKYDEERSLREAAEQKVTRLT----------EELNKEATVIQDLKTE 213

Query: 724  ALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 783
             L+     +++   + L +  T   + + + + E ++L +  K+++++    +  I++L 
Sbjct: 214  LLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLR 273

Query: 784  RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 843
             ++    ++VA   + ++++K KS+          + L   +Q L ++L KK+    +LE
Sbjct: 274  SELAKGPQEVA--VYVQELQKLKSSV---------NELTQKNQTLTENLLKKEQDYTKLE 322

Query: 844  E------ALRESVQITAEREMVLAQEESARTNAEK--------QVEELLMAMEKVKQEL- 888
            E        ++++Q T  ++ +  Q+  +R +A +        ++ E   A +K+K+EL 
Sbjct: 323  EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382

Query: 889  ------ESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
                  + +KA+    QQ   EKE H   L++E  +   ++LE +++   A    K+   
Sbjct: 383  EVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR- 441

Query: 943  ALLELSSSKKKTQE-EVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
               +LSS K   +E +VA L+ +  RL +QLK++  N  +L    ++ D  K  H  Q  
Sbjct: 442  ---QLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL---QHQLDKTKQQHQEQQA 495

Query: 1002 HKPSP-----------DQIIQPLLELDQNRSKLKLYI----GHLTTLCHDRDPLILRGLT 1046
             + S            +Q+++ + + DQ    L+  +     +++ L  +R+ L      
Sbjct: 496  LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLY----- 550

Query: 1047 PPASYNLDDDQAAWENELQKMTR------GQLQDELEKGERDNAELQEFANAILQQIADH 1100
              A     + + A  N+LQ+          QL ++L+     + + QE  +  +Q+   H
Sbjct: 551  --AKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAH 608

Query: 1101 CPDILEQVVN 1110
                 ++V++
Sbjct: 609  LRAAQDRVLS 618



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 72/330 (21%), Positives = 152/330 (46%), Gaps = 22/330 (6%)

Query: 163  RENDLL--RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQE 220
            RE++LL  R+D++  E KLS +   + +  +    + + +++ + +K T+ ++  +    
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK---- 1093

Query: 221  ENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT---EENFQRLHAEHERQ 277
            + Q +Q   +ALQD ++ ++ L +    +  S+  E  + E+    E+   +L+ E +  
Sbjct: 1094 KEQQLQERCKALQD-IQKEKSLKEKELVNEKSKLAE--IEEIKCRQEKEITKLNEELKSH 1150

Query: 278  AKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG--LSAKATEEDHERTRR 335
              E       L++ +  +  QK  L  + +S+K  +E  +     L  +  +E+ E  + 
Sbjct: 1151 KLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKE 1210

Query: 336  LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS---KIS 392
              E E  +H      E KEKE  M + E +        +A  + L TV +   S   ++S
Sbjct: 1211 FIEKEAKLHS-----EIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVS 1265

Query: 393  SMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEA 452
             +E+   DL  EI +L++    + +ER   +++        + ++ KV +L+ +L +  A
Sbjct: 1266 ELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTA 1325

Query: 453  QWEELKKKAAGLQAEIGQVKQELSRKDTEL 482
              +EL ++   LQ +  Q       +D E+
Sbjct: 1326 AVQELGRENQSLQIKHTQALNRKWAEDNEV 1355


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  161 bits (408), Expect = 3e-39
 Identities = 218/952 (22%), Positives = 419/952 (44%), Gaps = 154/952 (16%)

Query: 229  IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
            +QA +DEL     R Q+  N+L   +Q  S  T E  + +   +    L+AE        
Sbjct: 854  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 905

Query: 282  FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
                   EEM +R+  +KQ L       +++L  ++++       EE+ +R ++L AE +
Sbjct: 906  ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 946

Query: 341  MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
                 +  L EQ E+E +  R+++  + E     AK K L+  I + D + + + +  + 
Sbjct: 947  KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003

Query: 401  LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE-QLKEELSSKEAQWEELKK 459
            LEE I  L +N A    E EE+ K +   ++  + M +++E +LK+E  S++ + E+LK+
Sbjct: 1004 LEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKR 1058

Query: 460  KAAG-----------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
            K  G           LQA+I ++K +L++K+ E   LQ  L  L ++ +     ++ ++E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRE 1115

Query: 509  SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD---- 564
                       L+  +  L+  L+ +    NK  KQ +D+ EE      E+ D  D    
Sbjct: 1116 -----------LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164

Query: 565  ---MLDVKERKVNVLQKKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
               +   +E++V VL+K ++         +QE  +   + +  L E+++  +    N D 
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 614  ALTTLEE----------ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
               TLE+           L + ++ +E  K++ +   +E Q +  + ++   +L +KV  
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1284

Query: 664  LQ-------GDLSEKEASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEE 709
            LQ       G L+E E   + L +  +SL+S        L++++R K  +   L Q +EE
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344

Query: 710  CLKMESQLKKAHEAA--LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRL 761
               ++ QL +  EA   LE   S    ++SD   ++Q     +   ++   + Q E++ L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 762  LEILKE-------VENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKS 807
             +  +E       +E  KN   +++ +L   + +Q + V+NL+ K++        EK  S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464

Query: 808  AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
            ++  +E  R E    +   +     R  ++ +E  EE  R +  + AE E +++ ++   
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 868  TNA---EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---E 921
             N    EK    L   ME++K +LE ++ +L +T+ +    E ++  L+ +  + L   +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 922  EVLEMKQEALLAAISE-----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
            E  E K+  L   + E     +D        +++KKK + ++  L+ + D  ++  ++  
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 977  QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1036
            +   KL A        K       + + S D+I     E   N  K K     L  L  D
Sbjct: 1645 KQLRKLQA------QMKDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED 1695

Query: 1037 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1088
                +          +L+ ++ A E       R  LQDE  + E   A+L+E
Sbjct: 1696 ----LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743



 Score =  157 bits (398), Expect = 4e-38
 Identities = 201/896 (22%), Positives = 392/896 (43%), Gaps = 94/896 (10%)

Query: 154  LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
            LQ QL+   E+  E + +R  +  K+ +L   ++ ++     E  + + L   RK  A +
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 208  ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
            +   +EQ    +   Q +Q+        I+ L+DE+ +  D N       +L ++  S  
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 254  TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
            T      E   +N  +L  +HE    EL +  K  E+    +E  K+ L        + +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 314  EMLQS-----KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM--HR 366
              LQ+     K   AK  EE      RL +     ++    + + E   S L+E++   R
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 367  RFENAPDSAKT------KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
               N  +  K       +AL+T +E      ++ +      E+E+ +LK   AL  E R 
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK--ALDEETRS 1189

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSK---EAQWEELKKKAAGLQAEI---GQVKQE 474
             E +  E+ + H++ ++   EQL++   +K   +   + L+K+ A L  E+   GQ KQE
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 475  LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            +  K  +L A   +L++           L ++    +  +E +   L   E +A  L  +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
            V +L  +L++ + +L ++T+Q  +++ +      E + L+D LD +      L++ I  L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
              QL D +K++      V++L+         +  L +   EK    ++L++ ++R     
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1425

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            Q+E+D+   DL + ++ VS L+    + +  L + K  +S  A      D R +  E   
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1478

Query: 704  EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 762
             +K+ + L     L +A E ALEA+   E ++++   E E +   KD+  K   E+++  
Sbjct: 1479 REKETKALS----LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 763  EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
              L   E +  +   ++ ELE +++        L+   Q  K    Q   + + R++   
Sbjct: 1535 RAL---ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1588

Query: 823  DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 875
            +  +QLQ  L + +  +E+   + AL  + +   E ++  +  Q +SA   R  A KQ+ 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 876  ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 935
            +L   M+  ++ELE  +A       +  E E    +L A       ++++++++   A  
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1701

Query: 936  SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 985
            + K A++   EL+     +     AL+ EK RL  ++ Q      + Q  M+ M+D
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757



 Score =  138 bits (347), Expect = 3e-32
 Identities = 189/870 (21%), Positives = 374/870 (42%), Gaps = 126/870 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
            I DLQ Q+ E+  +  L +K+ E++      + +++   N++K     E         L 
Sbjct: 1071 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 196  KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
             ERA R K E  K  + +E   +  E    +  T  A Q ELR +R+      +   D  
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1186

Query: 252  SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
            +R+ E  V E+ +++ Q +        + +R    L   ++TLE+    +  + + L   
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246

Query: 306  DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
             + ++   + L+++    ++   D ER R  AE    VH L++   + E    ML E   
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1301

Query: 366  RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
            +  + A D    S++ +  Q +++ +  +  ++   LR LEEE   L+       ++ +E
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1354

Query: 422  EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK--- 478
            EM+  +    H   +  ++   K++L    +  E L++     Q EI  + Q+   K   
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 479  ----DTELLALQTKLETLTNQFSDSKQHIEVLK------ESLTAKEQR-AAILQTEVDAL 527
                +     LQ +L+ L     + +Q +  L+      + L A+E+  ++    E D  
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 528  RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK-DMLDVKERKVNVLQKKIENLQEQ 586
                 EKET      + +++  E K         LK +M D+   K +V  K +  L++ 
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKS 1533

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDERE 642
             R  E QM  +K +++ L+ +   T+ A   LE   +AL  + ER ++   EQ +   R+
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 643  KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702
             Q ++  Y+ +L+D +++ +L      + E  L DL+          L+ DS +K  E A
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEA 1643

Query: 703  LEQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---S 751
            ++Q +    K+++Q+K       +ARAS         E   + + LE ++ + +++   +
Sbjct: 1644 IKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 752  SKAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK- 799
             +A+ + D   E L E           +++EK   + +IA+LE +++++   +  +  + 
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 800  ------------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK-------- 835
                        E   ++ +AQ  E AR    R+   L     +++ +++ K        
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 836  DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
            + +I +LEE + +  +        L Q++        QVE+     E+ K++ E   A++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879

Query: 896  SSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
               ++ L E E     + A RRK   E+ E
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDE 1909



 Score =  130 bits (326), Expect = 9e-30
 Identities = 191/843 (22%), Positives = 358/843 (42%), Gaps = 138/843 (16%)

Query: 156  TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK---ERALRKDEASKITIWK 212
            + L+E L      R   E ++  L   + ++KT     L     ++ LR     ++T+ K
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 213  EQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
               + + EE +  +  +Q + Q   +   +L +  +Q   ++          ++N Q L 
Sbjct: 1181 ---KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-------LDKNKQTLE 1230

Query: 272  AEHERQAKELFLLRKTLEEME---LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
             E+   A EL +L +  +E+E    ++E Q Q L ++    ++    L  K    K   E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--VHKLQNE 1288

Query: 329  DHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
                T  L EAE     L     SL  Q +    +L+EE  ++      S K + L+   
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV---STKLRQLEEER 1345

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
                 ++       ++LE  I  L    + S ++ ++    +E      K  + ++E L 
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405

Query: 445  EELSSKEAQWEELKKKAAGLQAEIG----------QVKQELSRKDTELLALQTKLETLTN 494
            ++   K A +++L+K    LQ E+           Q+   L +K  +   L  + + +++
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465

Query: 495  QFSDSKQHIEV---------------LKESLTAKEQRAA---ILQTEVD----------- 525
            +++D +   E                L+E+L AKE+      +L+ E++           
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525

Query: 526  ----------ALRLRLEEKETMLNKKTKQIQDMAEEK-----GTQA--GEIH-DLKDMLD 567
                      AL  ++EE +T L +   ++Q   + K       QA  G+   DL+   +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585

Query: 568  VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN----TDTALTTLEEALA 623
              E K   LQ+++   + +L D+ KQ +      K L+ D  +     D+A+   EEA+ 
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645

Query: 624  EKERTIERLKE-QRD-RDEREKQEEI-----DNYKKDLKDLKEKVSLLQGDLS--EKEAS 674
            +  +   ++K+ QR+  D R  ++EI     +N KK  K L+  +  LQ DL+  E+   
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARK 1704

Query: 675  LLDLK------EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 728
              DL+      E ASSL+     +D + + LE  + Q +EE  + +  ++   +   +A 
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 729  ASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDK--------K 778
               E        ER  T  K+ES++ Q E     L   L E+E     K K        K
Sbjct: 1764 QQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822

Query: 779  IAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
            IA+LE QV+ +  +K A  K  +Q +KK     L+E   + ++    ++Q ++   K + 
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 838  RIEELEEALRESVQITAEREMVLAQEESARTNA-----EKQVEELLMAMEKVKQELESMK 892
            R+++L+  L E            A+EES R NA     +++++E   + E + +E+ ++K
Sbjct: 1878 RVKQLKRQLEE------------AEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925

Query: 893  AKL 895
            +KL
Sbjct: 1926 SKL 1928



 Score =  127 bits (319), Expect = 6e-29
 Identities = 179/840 (21%), Positives = 363/840 (43%), Gaps = 129/840 (15%)

Query: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
            HLE   + K  +  M  + M R +      AK +   T +++     ++  + LR+ +  
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 835

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
                K    L    +EEEM+  E     +K  + K E   +EL  K +Q  E K      
Sbjct: 836  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN----- 890

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAIL 520
                  + QE  + +TEL A   + E +  + +  KQ +E +   + A+    E R   L
Sbjct: 891  ------LLQEQLQAETELYA---EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 941

Query: 521  QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 580
            Q E   +  ++ + E  L ++    Q +  EK T   +I  L+D + V + + N L K+ 
Sbjct: 942  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 581  ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKEQRD 637
            + L+E++ D    ++  +E+ K+L       ++ ++ LE  L ++E++   +E+LK + +
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061

Query: 638  RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS---------------------EKEASLL 676
             D  +  E+I + +  + +LK +++  + +L                      E E  + 
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 677  DLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC--------------LKMESQ---LKK 719
            DL+E   S  ++  K + + + L   LE  K E                K E +   LKK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 720  A-------HEAALE------ARASPEMSDRIQHLER---EITRYKDESSKAQAEVDRLLE 763
            A       HEA ++      A+A  E++++++  +R    + + K    K  A++   L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241

Query: 764  IL----KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARR 816
            +L    +EVE++K   + ++ EL+ +  D  +  A L    HK Q E +    ML EA  
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 817  REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 876
            +   L      L   L+   D  E L+E  R+ + ++ +    L Q E  R + + Q++E
Sbjct: 1302 KAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK----LRQLEEERNSLQDQLDE 1354

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
             + A + +++ + ++  +LS +++ L +  + +  L   +++  +E+  + Q+       
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ-----YE 1409

Query: 937  EKDANIALLELSSSKKKTQEEVAALKREKD---RLVQQLKQQTQNRMKLMADNYEDDHFK 993
            EK A  A  +L  +K + Q+E+  L  + D   +LV  L+++ +   +L+A   E+ +  
Sbjct: 1410 EKAA--AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNIS 1464

Query: 994  SSHSNQTNHKPSP---------------DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1038
            S ++++ +   +                ++ ++   EL++    LK  +  L +   D  
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 1039 PLILRGLTPPASYNLDDDQAAWENELQKMTR--GQLQDELEKGERDNAELQEFANAILQQ 1096
              +         + L+  + A E ++++M     +L+DEL+  E     L+    A+  Q
Sbjct: 1525 KNV---------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575



 Score =  112 bits (279), Expect = 3e-24
 Identities = 151/688 (21%), Positives = 290/688 (42%), Gaps = 102/688 (14%)

Query: 139  VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
            V   LRQ  +     LQ QL E +     L + +     +LS S   ++ F S    L++
Sbjct: 1334 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 197  ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
             +   + E   +T   E+    Y  +++    +Q  +  L  +L  QR L  +   +   
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1450

Query: 253  RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
            R  +  +AE  E+N    +A+          E++ K L L R   E +E + E ++    
Sbjct: 1451 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508

Query: 302  --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
                    ++++D+  K + E+ +SK  L  +  E        ED  +    A+  + V+
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 345  ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394
                       L++  EQ E++   L+ ++H       D  K +AL    + K      +
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------L 1622

Query: 395  ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
            E  L+DLE     L+++ A+  + REE +KQ+   ++  K  + ++E  +       A  
Sbjct: 1623 EGDLKDLE-----LQADSAI--KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 455  EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
            +E +KKA  L+A++ Q++++L+  +        + E L  + + S      L++     E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 515  QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
             R A L+ E++  +  +E     + K T+Q + ++ E  T+               +K  
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNE 1784

Query: 575  VLQKKIENLQEQLRDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
              ++++E   ++LR K  +M  ++K + KS                  +A  E  I +L+
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLE 1827

Query: 634  EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
            EQ +++ REKQ    + K+  KD K K  LLQ +   K A     KE A        K +
Sbjct: 1828 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGN 1876

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK 753
            +R+K L+  LE+ +EE  ++ +  +K      EA  S E   R  +  +   R  +E+S 
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1936

Query: 754  AQAEVDRLLEILKEVENEKNDKDKKIAE 781
              +       +++  +  + + D + A+
Sbjct: 1937 VPSRRSGGRRVIENADGSEEETDTRDAD 1964


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  161 bits (408), Expect = 3e-39
 Identities = 218/952 (22%), Positives = 419/952 (44%), Gaps = 154/952 (16%)

Query: 229  IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
            +QA +DEL     R Q+  N+L   +Q  S  T E  + +   +    L+AE        
Sbjct: 861  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 912

Query: 282  FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
                   EEM +R+  +KQ L       +++L  ++++       EE+ +R ++L AE +
Sbjct: 913  ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 953

Query: 341  MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
                 +  L EQ E+E +  R+++  + E     AK K L+  I + D + + + +  + 
Sbjct: 954  KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010

Query: 401  LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE-QLKEELSSKEAQWEELKK 459
            LEE I  L +N A    E EE+ K +   ++  + M +++E +LK+E  S++ + E+LK+
Sbjct: 1011 LEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKR 1065

Query: 460  KAAG-----------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
            K  G           LQA+I ++K +L++K+ E   LQ  L  L ++ +     ++ ++E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRE 1122

Query: 509  SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD---- 564
                       L+  +  L+  L+ +    NK  KQ +D+ EE      E+ D  D    
Sbjct: 1123 -----------LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171

Query: 565  ---MLDVKERKVNVLQKKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
               +   +E++V VL+K ++         +QE  +   + +  L E+++  +    N D 
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 614  ALTTLEE----------ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
               TLE+           L + ++ +E  K++ +   +E Q +  + ++   +L +KV  
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291

Query: 664  LQ-------GDLSEKEASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEE 709
            LQ       G L+E E   + L +  +SL+S        L++++R K  +   L Q +EE
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351

Query: 710  CLKMESQLKKAHEAA--LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRL 761
               ++ QL +  EA   LE   S    ++SD   ++Q     +   ++   + Q E++ L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 762  LEILKE-------VENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKS 807
             +  +E       +E  KN   +++ +L   + +Q + V+NL+ K++        EK  S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471

Query: 808  AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
            ++  +E  R E    +   +     R  ++ +E  EE  R +  + AE E +++ ++   
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 868  TNA---EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---E 921
             N    EK    L   ME++K +LE ++ +L +T+ +    E ++  L+ +  + L   +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 922  EVLEMKQEALLAAISE-----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
            E  E K+  L   + E     +D        +++KKK + ++  L+ + D  ++  ++  
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 977  QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1036
            +   KL A        K       + + S D+I     E   N  K K     L  L  D
Sbjct: 1652 KQLRKLQA------QMKDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED 1702

Query: 1037 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1088
                +          +L+ ++ A E       R  LQDE  + E   A+L+E
Sbjct: 1703 ----LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750



 Score =  157 bits (398), Expect = 4e-38
 Identities = 201/896 (22%), Positives = 392/896 (43%), Gaps = 94/896 (10%)

Query: 154  LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
            LQ QL+   E+  E + +R  +  K+ +L   ++ ++     E  + + L   RK  A +
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 208  ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
            +   +EQ    +   Q +Q+        I+ L+DE+ +  D N       +L ++  S  
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 254  TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
            T      E   +N  +L  +HE    EL +  K  E+    +E  K+ L        + +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 314  EMLQS-----KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM--HR 366
              LQ+     K   AK  EE      RL +     ++    + + E   S L+E++   R
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 367  RFENAPDSAKT------KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
               N  +  K       +AL+T +E      ++ +      E+E+ +LK   AL  E R 
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK--ALDEETRS 1196

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSK---EAQWEELKKKAAGLQAEI---GQVKQE 474
             E +  E+ + H++ ++   EQL++   +K   +   + L+K+ A L  E+   GQ KQE
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 475  LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            +  K  +L A   +L++           L ++    +  +E +   L   E +A  L  +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
            V +L  +L++ + +L ++T+Q  +++ +      E + L+D LD +      L++ I  L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
              QL D +K++      V++L+         +  L +   EK    ++L++ ++R     
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1432

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            Q+E+D+   DL + ++ VS L+    + +  L + K  +S  A      D R +  E   
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1485

Query: 704  EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 762
             +K+ + L     L +A E ALEA+   E ++++   E E +   KD+  K   E+++  
Sbjct: 1486 REKETKALS----LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 763  EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
              L   E +  +   ++ ELE +++        L+   Q  K    Q   + + R++   
Sbjct: 1542 RAL---ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1595

Query: 823  DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 875
            +  +QLQ  L + +  +E+   + AL  + +   E ++  +  Q +SA   R  A KQ+ 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 876  ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 935
            +L   M+  ++ELE  +A       +  E E    +L A       ++++++++   A  
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1708

Query: 936  SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 985
            + K A++   EL+     +     AL+ EK RL  ++ Q      + Q  M+ M+D
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764



 Score =  138 bits (347), Expect = 3e-32
 Identities = 189/870 (21%), Positives = 374/870 (42%), Gaps = 126/870 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
            I DLQ Q+ E+  +  L +K+ E++      + +++   N++K     E         L 
Sbjct: 1078 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 196  KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
             ERA R K E  K  + +E   +  E    +  T  A Q ELR +R+      +   D  
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1193

Query: 252  SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
            +R+ E  V E+ +++ Q +        + +R    L   ++TLE+    +  + + L   
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253

Query: 306  DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
             + ++   + L+++    ++   D ER R  AE    VH L++   + E    ML E   
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1308

Query: 366  RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
            +  + A D    S++ +  Q +++ +  +  ++   LR LEEE   L+       ++ +E
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1361

Query: 422  EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK--- 478
            EM+  +    H   +  ++   K++L    +  E L++     Q EI  + Q+   K   
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 479  ----DTELLALQTKLETLTNQFSDSKQHIEVLK------ESLTAKEQR-AAILQTEVDAL 527
                +     LQ +L+ L     + +Q +  L+      + L A+E+  ++    E D  
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 528  RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK-DMLDVKERKVNVLQKKIENLQEQ 586
                 EKET      + +++  E K         LK +M D+   K +V  K +  L++ 
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKS 1540

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDERE 642
             R  E QM  +K +++ L+ +   T+ A   LE   +AL  + ER ++   EQ +   R+
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 643  KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702
             Q ++  Y+ +L+D +++ +L      + E  L DL+          L+ DS +K  E A
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEA 1650

Query: 703  LEQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---S 751
            ++Q +    K+++Q+K       +ARAS         E   + + LE ++ + +++   +
Sbjct: 1651 IKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 752  SKAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK- 799
             +A+ + D   E L E           +++EK   + +IA+LE +++++   +  +  + 
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 800  ------------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK-------- 835
                        E   ++ +AQ  E AR    R+   L     +++ +++ K        
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 836  DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
            + +I +LEE + +  +        L Q++        QVE+     E+ K++ E   A++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886

Query: 896  SSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
               ++ L E E     + A RRK   E+ E
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDE 1916



 Score =  130 bits (326), Expect = 9e-30
 Identities = 191/843 (22%), Positives = 358/843 (42%), Gaps = 138/843 (16%)

Query: 156  TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK---ERALRKDEASKITIWK 212
            + L+E L      R   E ++  L   + ++KT     L     ++ LR     ++T+ K
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 213  EQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
               + + EE +  +  +Q + Q   +   +L +  +Q   ++          ++N Q L 
Sbjct: 1188 ---KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-------LDKNKQTLE 1237

Query: 272  AEHERQAKELFLLRKTLEEME---LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
             E+   A EL +L +  +E+E    ++E Q Q L ++    ++    L  K    K   E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--VHKLQNE 1295

Query: 329  DHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
                T  L EAE     L     SL  Q +    +L+EE  ++      S K + L+   
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV---STKLRQLEEER 1352

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
                 ++       ++LE  I  L    + S ++ ++    +E      K  + ++E L 
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412

Query: 445  EELSSKEAQWEELKKKAAGLQAEIG----------QVKQELSRKDTELLALQTKLETLTN 494
            ++   K A +++L+K    LQ E+           Q+   L +K  +   L  + + +++
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472

Query: 495  QFSDSKQHIEV---------------LKESLTAKEQRAA---ILQTEVD----------- 525
            +++D +   E                L+E+L AKE+      +L+ E++           
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532

Query: 526  ----------ALRLRLEEKETMLNKKTKQIQDMAEEK-----GTQA--GEIH-DLKDMLD 567
                      AL  ++EE +T L +   ++Q   + K       QA  G+   DL+   +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592

Query: 568  VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN----TDTALTTLEEALA 623
              E K   LQ+++   + +L D+ KQ +      K L+ D  +     D+A+   EEA+ 
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652

Query: 624  EKERTIERLKE-QRD-RDEREKQEEI-----DNYKKDLKDLKEKVSLLQGDLS--EKEAS 674
            +  +   ++K+ QR+  D R  ++EI     +N KK  K L+  +  LQ DL+  E+   
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARK 1711

Query: 675  LLDLK------EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 728
              DL+      E ASSL+     +D + + LE  + Q +EE  + +  ++   +   +A 
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 729  ASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDK--------K 778
               E        ER  T  K+ES++ Q E     L   L E+E     K K        K
Sbjct: 1771 QQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 779  IAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
            IA+LE QV+ +  +K A  K  +Q +KK     L+E   + ++    ++Q ++   K + 
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 838  RIEELEEALRESVQITAEREMVLAQEESARTNA-----EKQVEELLMAMEKVKQELESMK 892
            R+++L+  L E            A+EES R NA     +++++E   + E + +E+ ++K
Sbjct: 1885 RVKQLKRQLEE------------AEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932

Query: 893  AKL 895
            +KL
Sbjct: 1933 SKL 1935



 Score =  127 bits (319), Expect = 6e-29
 Identities = 179/840 (21%), Positives = 363/840 (43%), Gaps = 129/840 (15%)

Query: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
            HLE   + K  +  M  + M R +      AK +   T +++     ++  + LR+ +  
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 842

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
                K    L    +EEEM+  E     +K  + K E   +EL  K +Q  E K      
Sbjct: 843  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN----- 897

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAIL 520
                  + QE  + +TEL A   + E +  + +  KQ +E +   + A+    E R   L
Sbjct: 898  ------LLQEQLQAETELYA---EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 948

Query: 521  QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 580
            Q E   +  ++ + E  L ++    Q +  EK T   +I  L+D + V + + N L K+ 
Sbjct: 949  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 581  ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKEQRD 637
            + L+E++ D    ++  +E+ K+L       ++ ++ LE  L ++E++   +E+LK + +
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068

Query: 638  RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS---------------------EKEASLL 676
             D  +  E+I + +  + +LK +++  + +L                      E E  + 
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 677  DLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC--------------LKMESQ---LKK 719
            DL+E   S  ++  K + + + L   LE  K E                K E +   LKK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 720  A-------HEAALE------ARASPEMSDRIQHLER---EITRYKDESSKAQAEVDRLLE 763
            A       HEA ++      A+A  E++++++  +R    + + K    K  A++   L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248

Query: 764  IL----KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARR 816
            +L    +EVE++K   + ++ EL+ +  D  +  A L    HK Q E +    ML EA  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 817  REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 876
            +   L      L   L+   D  E L+E  R+ + ++ +    L Q E  R + + Q++E
Sbjct: 1309 KAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK----LRQLEEERNSLQDQLDE 1361

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
             + A + +++ + ++  +LS +++ L +  + +  L   +++  +E+  + Q+       
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ-----YE 1416

Query: 937  EKDANIALLELSSSKKKTQEEVAALKREKD---RLVQQLKQQTQNRMKLMADNYEDDHFK 993
            EK A  A  +L  +K + Q+E+  L  + D   +LV  L+++ +   +L+A   E+ +  
Sbjct: 1417 EKAA--AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNIS 1471

Query: 994  SSHSNQTNHKPSP---------------DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1038
            S ++++ +   +                ++ ++   EL++    LK  +  L +   D  
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 1039 PLILRGLTPPASYNLDDDQAAWENELQKMTR--GQLQDELEKGERDNAELQEFANAILQQ 1096
              +         + L+  + A E ++++M     +L+DEL+  E     L+    A+  Q
Sbjct: 1532 KNV---------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582



 Score =  112 bits (279), Expect = 3e-24
 Identities = 151/688 (21%), Positives = 290/688 (42%), Gaps = 102/688 (14%)

Query: 139  VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
            V   LRQ  +     LQ QL E +     L + +     +LS S   ++ F S    L++
Sbjct: 1341 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 197  ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
             +   + E   +T   E+    Y  +++    +Q  +  L  +L  QR L  +   +   
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1457

Query: 253  RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
            R  +  +AE  E+N    +A+          E++ K L L R   E +E + E ++    
Sbjct: 1458 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515

Query: 302  --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
                    ++++D+  K + E+ +SK  L  +  E        ED  +    A+  + V+
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 345  ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394
                       L++  EQ E++   L+ ++H       D  K +AL    + K      +
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------L 1629

Query: 395  ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
            E  L+DLE     L+++ A+  + REE +KQ+   ++  K  + ++E  +       A  
Sbjct: 1630 EGDLKDLE-----LQADSAI--KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 455  EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
            +E +KKA  L+A++ Q++++L+  +        + E L  + + S      L++     E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 515  QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
             R A L+ E++  +  +E     + K T+Q + ++ E  T+               +K  
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNE 1791

Query: 575  VLQKKIENLQEQLRDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
              ++++E   ++LR K  +M  ++K + KS                  +A  E  I +L+
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLE 1834

Query: 634  EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
            EQ +++ REKQ    + K+  KD K K  LLQ +   K A     KE A        K +
Sbjct: 1835 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGN 1883

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK 753
            +R+K L+  LE+ +EE  ++ +  +K      EA  S E   R  +  +   R  +E+S 
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSF 1943

Query: 754  AQAEVDRLLEILKEVENEKNDKDKKIAE 781
              +       +++  +  + + D + A+
Sbjct: 1944 VPSRRSGGRRVIENADGSEEETDTRDAD 1971


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  161 bits (408), Expect = 3e-39
 Identities = 218/952 (22%), Positives = 419/952 (44%), Gaps = 154/952 (16%)

Query: 229  IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
            +QA +DEL     R Q+  N+L   +Q  S  T E  + +   +    L+AE        
Sbjct: 861  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 912

Query: 282  FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
                   EEM +R+  +KQ L       +++L  ++++       EE+ +R ++L AE +
Sbjct: 913  ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 953

Query: 341  MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
                 +  L EQ E+E +  R+++  + E     AK K L+  I + D + + + +  + 
Sbjct: 954  KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1010

Query: 401  LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE-QLKEELSSKEAQWEELKK 459
            LEE I  L +N A    E EE+ K +   ++  + M +++E +LK+E  S++ + E+LK+
Sbjct: 1011 LEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKR 1065

Query: 460  KAAG-----------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
            K  G           LQA+I ++K +L++K+ E   LQ  L  L ++ +     ++ ++E
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRE 1122

Query: 509  SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD---- 564
                       L+  +  L+  L+ +    NK  KQ +D+ EE      E+ D  D    
Sbjct: 1123 -----------LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1171

Query: 565  ---MLDVKERKVNVLQKKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
               +   +E++V VL+K ++         +QE  +   + +  L E+++  +    N D 
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231

Query: 614  ALTTLEE----------ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
               TLE+           L + ++ +E  K++ +   +E Q +  + ++   +L +KV  
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291

Query: 664  LQ-------GDLSEKEASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEE 709
            LQ       G L+E E   + L +  +SL+S        L++++R K  +   L Q +EE
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351

Query: 710  CLKMESQLKKAHEAA--LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRL 761
               ++ QL +  EA   LE   S    ++SD   ++Q     +   ++   + Q E++ L
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411

Query: 762  LEILKE-------VENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKS 807
             +  +E       +E  KN   +++ +L   + +Q + V+NL+ K++        EK  S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471

Query: 808  AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
            ++  +E  R E    +   +     R  ++ +E  EE  R +  + AE E +++ ++   
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 868  TNA---EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---E 921
             N    EK    L   ME++K +LE ++ +L +T+ +    E ++  L+ +  + L   +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591

Query: 922  EVLEMKQEALLAAISE-----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
            E  E K+  L   + E     +D        +++KKK + ++  L+ + D  ++  ++  
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

Query: 977  QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1036
            +   KL A        K       + + S D+I     E   N  K K     L  L  D
Sbjct: 1652 KQLRKLQA------QMKDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED 1702

Query: 1037 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1088
                +          +L+ ++ A E       R  LQDE  + E   A+L+E
Sbjct: 1703 ----LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1750



 Score =  157 bits (398), Expect = 4e-38
 Identities = 201/896 (22%), Positives = 392/896 (43%), Gaps = 94/896 (10%)

Query: 154  LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
            LQ QL+   E+  E + +R  +  K+ +L   ++ ++     E  + + L   RK  A +
Sbjct: 899  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 958

Query: 208  ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
            +   +EQ    +   Q +Q+        I+ L+DE+ +  D N       +L ++  S  
Sbjct: 959  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018

Query: 254  TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
            T      E   +N  +L  +HE    EL +  K  E+    +E  K+ L        + +
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078

Query: 314  EMLQS-----KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM--HR 366
              LQ+     K   AK  EE      RL +     ++    + + E   S L+E++   R
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1138

Query: 367  RFENAPDSAKT------KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
               N  +  K       +AL+T +E      ++ +      E+E+ +LK   AL  E R 
Sbjct: 1139 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK--ALDEETRS 1196

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSK---EAQWEELKKKAAGLQAEI---GQVKQE 474
             E +  E+ + H++ ++   EQL++   +K   +   + L+K+ A L  E+   GQ KQE
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256

Query: 475  LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            +  K  +L A   +L++           L ++    +  +E +   L   E +A  L  +
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1316

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
            V +L  +L++ + +L ++T+Q  +++ +      E + L+D LD +      L++ I  L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
              QL D +K++      V++L+         +  L +   EK    ++L++ ++R     
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1432

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            Q+E+D+   DL + ++ VS L+    + +  L + K  +S  A      D R +  E   
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1485

Query: 704  EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 762
             +K+ + L     L +A E ALEA+   E ++++   E E +   KD+  K   E+++  
Sbjct: 1486 REKETKALS----LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1541

Query: 763  EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
              L   E +  +   ++ ELE +++        L+   Q  K    Q   + + R++   
Sbjct: 1542 RAL---ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1595

Query: 823  DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 875
            +  +QLQ  L + +  +E+   + AL  + +   E ++  +  Q +SA   R  A KQ+ 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 876  ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 935
            +L   M+  ++ELE  +A       +  E E    +L A       ++++++++   A  
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1708

Query: 936  SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 985
            + K A++   EL+     +     AL+ EK RL  ++ Q      + Q  M+ M+D
Sbjct: 1709 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764



 Score =  138 bits (347), Expect = 3e-32
 Identities = 189/870 (21%), Positives = 374/870 (42%), Gaps = 126/870 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
            I DLQ Q+ E+  +  L +K+ E++      + +++   N++K     E         L 
Sbjct: 1078 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1135

Query: 196  KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
             ERA R K E  K  + +E   +  E    +  T  A Q ELR +R+      +   D  
Sbjct: 1136 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1193

Query: 252  SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
            +R+ E  V E+ +++ Q +        + +R    L   ++TLE+    +  + + L   
Sbjct: 1194 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1253

Query: 306  DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
             + ++   + L+++    ++   D ER R  AE    VH L++   + E    ML E   
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1308

Query: 366  RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
            +  + A D    S++ +  Q +++ +  +  ++   LR LEEE   L+       ++ +E
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1361

Query: 422  EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK--- 478
            EM+  +    H   +  ++   K++L    +  E L++     Q EI  + Q+   K   
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421

Query: 479  ----DTELLALQTKLETLTNQFSDSKQHIEVLK------ESLTAKEQR-AAILQTEVDAL 527
                +     LQ +L+ L     + +Q +  L+      + L A+E+  ++    E D  
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481

Query: 528  RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK-DMLDVKERKVNVLQKKIENLQEQ 586
                 EKET      + +++  E K         LK +M D+   K +V  K +  L++ 
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKS 1540

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDERE 642
             R  E QM  +K +++ L+ +   T+ A   LE   +AL  + ER ++   EQ +   R+
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1600

Query: 643  KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702
             Q ++  Y+ +L+D +++ +L      + E  L DL+          L+ DS +K  E A
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEA 1650

Query: 703  LEQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---S 751
            ++Q +    K+++Q+K       +ARAS         E   + + LE ++ + +++   +
Sbjct: 1651 IKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1706

Query: 752  SKAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK- 799
             +A+ + D   E L E           +++EK   + +IA+LE +++++   +  +  + 
Sbjct: 1707 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766

Query: 800  ------------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK-------- 835
                        E   ++ +AQ  E AR    R+   L     +++ +++ K        
Sbjct: 1767 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826

Query: 836  DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
            + +I +LEE + +  +        L Q++        QVE+     E+ K++ E   A++
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886

Query: 896  SSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
               ++ L E E     + A RRK   E+ E
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDE 1916



 Score =  130 bits (326), Expect = 9e-30
 Identities = 191/843 (22%), Positives = 358/843 (42%), Gaps = 138/843 (16%)

Query: 156  TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK---ERALRKDEASKITIWK 212
            + L+E L      R   E ++  L   + ++KT     L     ++ LR     ++T+ K
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187

Query: 213  EQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
               + + EE +  +  +Q + Q   +   +L +  +Q   ++          ++N Q L 
Sbjct: 1188 ---KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-------LDKNKQTLE 1237

Query: 272  AEHERQAKELFLLRKTLEEME---LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
             E+   A EL +L +  +E+E    ++E Q Q L ++    ++    L  K    K   E
Sbjct: 1238 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--VHKLQNE 1295

Query: 329  DHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
                T  L EAE     L     SL  Q +    +L+EE  ++      S K + L+   
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV---STKLRQLEEER 1352

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
                 ++       ++LE  I  L    + S ++ ++    +E      K  + ++E L 
Sbjct: 1353 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412

Query: 445  EELSSKEAQWEELKKKAAGLQAEIG----------QVKQELSRKDTELLALQTKLETLTN 494
            ++   K A +++L+K    LQ E+           Q+   L +K  +   L  + + +++
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472

Query: 495  QFSDSKQHIEV---------------LKESLTAKEQRAA---ILQTEVD----------- 525
            +++D +   E                L+E+L AKE+      +L+ E++           
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1532

Query: 526  ----------ALRLRLEEKETMLNKKTKQIQDMAEEK-----GTQA--GEIH-DLKDMLD 567
                      AL  ++EE +T L +   ++Q   + K       QA  G+   DL+   +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592

Query: 568  VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN----TDTALTTLEEALA 623
              E K   LQ+++   + +L D+ KQ +      K L+ D  +     D+A+   EEA+ 
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652

Query: 624  EKERTIERLKE-QRD-RDEREKQEEI-----DNYKKDLKDLKEKVSLLQGDLS--EKEAS 674
            +  +   ++K+ QR+  D R  ++EI     +N KK  K L+  +  LQ DL+  E+   
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARK 1711

Query: 675  LLDLK------EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 728
              DL+      E ASSL+     +D + + LE  + Q +EE  + +  ++   +   +A 
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770

Query: 729  ASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDK--------K 778
               E        ER  T  K+ES++ Q E     L   L E+E     K K        K
Sbjct: 1771 QQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829

Query: 779  IAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
            IA+LE QV+ +  +K A  K  +Q +KK     L+E   + ++    ++Q ++   K + 
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 838  RIEELEEALRESVQITAEREMVLAQEESARTNA-----EKQVEELLMAMEKVKQELESMK 892
            R+++L+  L E            A+EES R NA     +++++E   + E + +E+ ++K
Sbjct: 1885 RVKQLKRQLEE------------AEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932

Query: 893  AKL 895
            +KL
Sbjct: 1933 SKL 1935



 Score =  127 bits (319), Expect = 6e-29
 Identities = 179/840 (21%), Positives = 363/840 (43%), Gaps = 129/840 (15%)

Query: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
            HLE   + K  +  M  + M R +      AK +   T +++     ++  + LR+ +  
Sbjct: 784  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 842

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
                K    L    +EEEM+  E     +K  + K E   +EL  K +Q  E K      
Sbjct: 843  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN----- 897

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAIL 520
                  + QE  + +TEL A   + E +  + +  KQ +E +   + A+    E R   L
Sbjct: 898  ------LLQEQLQAETELYA---EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 948

Query: 521  QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 580
            Q E   +  ++ + E  L ++    Q +  EK T   +I  L+D + V + + N L K+ 
Sbjct: 949  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1008

Query: 581  ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKEQRD 637
            + L+E++ D    ++  +E+ K+L       ++ ++ LE  L ++E++   +E+LK + +
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068

Query: 638  RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS---------------------EKEASLL 676
             D  +  E+I + +  + +LK +++  + +L                      E E  + 
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1128

Query: 677  DLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC--------------LKMESQ---LKK 719
            DL+E   S  ++  K + + + L   LE  K E                K E +   LKK
Sbjct: 1129 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1188

Query: 720  A-------HEAALE------ARASPEMSDRIQHLER---EITRYKDESSKAQAEVDRLLE 763
            A       HEA ++      A+A  E++++++  +R    + + K    K  A++   L 
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1248

Query: 764  IL----KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARR 816
            +L    +EVE++K   + ++ EL+ +  D  +  A L    HK Q E +    ML EA  
Sbjct: 1249 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 817  REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 876
            +   L      L   L+   D  E L+E  R+ + ++ +    L Q E  R + + Q++E
Sbjct: 1309 KAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK----LRQLEEERNSLQDQLDE 1361

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
             + A + +++ + ++  +LS +++ L +  + +  L   +++  +E+  + Q+       
Sbjct: 1362 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ-----YE 1416

Query: 937  EKDANIALLELSSSKKKTQEEVAALKREKD---RLVQQLKQQTQNRMKLMADNYEDDHFK 993
            EK A  A  +L  +K + Q+E+  L  + D   +LV  L+++ +   +L+A   E+ +  
Sbjct: 1417 EKAA--AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNIS 1471

Query: 994  SSHSNQTNHKPSP---------------DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1038
            S ++++ +   +                ++ ++   EL++    LK  +  L +   D  
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531

Query: 1039 PLILRGLTPPASYNLDDDQAAWENELQKMTR--GQLQDELEKGERDNAELQEFANAILQQ 1096
              +         + L+  + A E ++++M     +L+DEL+  E     L+    A+  Q
Sbjct: 1532 KNV---------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582



 Score =  108 bits (271), Expect = 2e-23
 Identities = 146/643 (22%), Positives = 272/643 (42%), Gaps = 102/643 (15%)

Query: 139  VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
            V   LRQ  +     LQ QL E +     L + +     +LS S   ++ F S    L++
Sbjct: 1341 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 197  ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
             +   + E   +T   E+    Y  +++    +Q  +  L  +L  QR L  +   +   
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1457

Query: 253  RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
            R  +  +AE  E+N    +A+          E++ K L L R   E +E + E ++    
Sbjct: 1458 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1515

Query: 302  --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
                    ++++D+  K + E+ +SK  L  +  E        ED  +    A+  + V+
Sbjct: 1516 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1575

Query: 345  ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394
                       L++  EQ E++   L+ ++H       D  K +AL    + K      +
Sbjct: 1576 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------L 1629

Query: 395  ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
            E  L+DLE     L+++ A+  + REE +KQ+   ++  K  + ++E  +       A  
Sbjct: 1630 EGDLKDLE-----LQADSAI--KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1682

Query: 455  EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
            +E +KKA  L+A++ Q++++L+  +        + E L  + + S      L++     E
Sbjct: 1683 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1742

Query: 515  QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
             R A L+ E++  +  +E     + K T+Q + ++ E  T+               +K  
Sbjct: 1743 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNE 1791

Query: 575  VLQKKIENLQEQLRDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
              ++++E   ++LR K  +M  ++K + KS                  +A  E  I +L+
Sbjct: 1792 SARQQLERQNKELRSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLE 1834

Query: 634  EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
            EQ +++ REKQ    + K+  KD K K  LLQ +   K A     KE A        K +
Sbjct: 1835 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGN 1883

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
            +R+K L+  LE+ +EE  ++ +  +K      EA  S E   R
Sbjct: 1884 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  161 bits (408), Expect = 3e-39
 Identities = 218/952 (22%), Positives = 419/952 (44%), Gaps = 154/952 (16%)

Query: 229  IQALQDEL-----RIQRDLNQL--FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKEL 281
            +QA +DEL     R Q+  N+L   +Q  S  T E  + +   +    L+AE        
Sbjct: 854  MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE-------- 905

Query: 282  FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL-AEAE 340
                   EEM +R+  +KQ L       +++L  ++++       EE+ +R ++L AE +
Sbjct: 906  ------AEEMRVRLAAKKQEL-------EEILHEMEAR------LEEEEDRGQQLQAERK 946

Query: 341  MHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRD 400
                 +  L EQ E+E +  R+++  + E     AK K L+  I + D + + + +  + 
Sbjct: 947  KMAQQMLDLEEQLEEEEA-ARQKL--QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL 1003

Query: 401  LEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVE-QLKEELSSKEAQWEELKK 459
            LEE I  L +N A    E EE+ K +   ++  + M +++E +LK+E  S++ + E+LK+
Sbjct: 1004 LEERISDLTTNLA----EEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ-ELEKLKR 1058

Query: 460  KAAG-----------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
            K  G           LQA+I ++K +L++K+ E   LQ  L  L ++ +     ++ ++E
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQLAKKEEE---LQAALARLDDEIAQKNNALKKIRE 1115

Query: 509  SLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD---- 564
                       L+  +  L+  L+ +    NK  KQ +D+ EE      E+ D  D    
Sbjct: 1116 -----------LEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTAT 1164

Query: 565  ---MLDVKERKVNVLQKKIE--------NLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
               +   +E++V VL+K ++         +QE  +   + +  L E+++  +    N D 
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224

Query: 614  ALTTLEE----------ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSL 663
               TLE+           L + ++ +E  K++ +   +E Q +  + ++   +L +KV  
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1284

Query: 664  LQ-------GDLSEKEASLLDLKEHASSLAS------SGLKKDSRLK-TLEIALEQKKEE 709
            LQ       G L+E E   + L +  +SL+S        L++++R K  +   L Q +EE
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344

Query: 710  CLKMESQLKKAHEAA--LEARASP---EMSD---RIQHLEREITRYKDESSKAQAEVDRL 761
               ++ QL +  EA   LE   S    ++SD   ++Q     +   ++   + Q E++ L
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404

Query: 762  LEILKE-------VENEKNDKDKKIAELERQVKDQNKKVANLKHKEQ-------VEKKKS 807
             +  +E       +E  KN   +++ +L   + +Q + V+NL+ K++        EK  S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464

Query: 808  AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESAR 867
            ++  +E  R E    +   +     R  ++ +E  EE  R +  + AE E +++ ++   
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 868  TNA---EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL---E 921
             N    EK    L   ME++K +LE ++ +L +T+ +    E ++  L+ +  + L   +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584

Query: 922  EVLEMKQEALLAAISE-----KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQT 976
            E  E K+  L   + E     +D        +++KKK + ++  L+ + D  ++  ++  
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644

Query: 977  QNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHD 1036
            +   KL A        K       + + S D+I     E   N  K K     L  L  D
Sbjct: 1645 KQLRKLQA------QMKDFQRELEDARASRDEIFATAKE---NEKKAKSLEADLMQLQED 1695

Query: 1037 RDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQE 1088
                +          +L+ ++ A E       R  LQDE  + E   A+L+E
Sbjct: 1696 ----LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE 1743



 Score =  157 bits (398), Expect = 4e-38
 Identities = 201/896 (22%), Positives = 392/896 (43%), Gaps = 94/896 (10%)

Query: 154  LQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL---RKDEASK 207
            LQ QL+   E+  E + +R  +  K+ +L   ++ ++     E  + + L   RK  A +
Sbjct: 892  LQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQ 951

Query: 208  ITIWKEQYRVVQEENQHMQMT-------IQALQDELRIQRDLN-------QLFQQDSSSR 253
            +   +EQ    +   Q +Q+        I+ L+DE+ +  D N       +L ++  S  
Sbjct: 952  MLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011

Query: 254  TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
            T      E   +N  +L  +HE    EL +  K  E+    +E  K+ L        + +
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071

Query: 314  EMLQS-----KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM--HR 366
              LQ+     K   AK  EE      RL +     ++    + + E   S L+E++   R
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSER 1131

Query: 367  RFENAPDSAKT------KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEERE 420
               N  +  K       +AL+T +E      ++ +      E+E+ +LK   AL  E R 
Sbjct: 1132 AARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK--ALDEETRS 1189

Query: 421  EEMKQMEVYRSHSKFMKNKVEQLKEELSSK---EAQWEELKKKAAGLQAEI---GQVKQE 474
             E +  E+ + H++ ++   EQL++   +K   +   + L+K+ A L  E+   GQ KQE
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249

Query: 475  LSRKDTELLALQTKLET-----------LTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            +  K  +L A   +L++           L ++    +  +E +   L   E +A  L  +
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKD 1309

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
            V +L  +L++ + +L ++T+Q  +++ +      E + L+D LD +      L++ I  L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
              QL D +K++      V++L+         +  L +   EK    ++L++ ++R     
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNR----L 1425

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            Q+E+D+   DL + ++ VS L+    + +  L + K  +S  A      D R +  E   
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA------DERDRA-EAEA 1478

Query: 704  EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLERE-ITRYKDESSKAQAEVDRLL 762
             +K+ + L     L +A E ALEA+   E ++++   E E +   KD+  K   E+++  
Sbjct: 1479 REKETKALS----LARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSK 1534

Query: 763  EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
              L   E +  +   ++ ELE +++        L+   Q  K    Q   + + R++   
Sbjct: 1535 RAL---ETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK---GQFERDLQARDEQNE 1588

Query: 823  DSSQQLQDSLRKKDDRIEE--LEEALRESVQITAEREM--VLAQEESA---RTNAEKQVE 875
            +  +QLQ  L + +  +E+   + AL  + +   E ++  +  Q +SA   R  A KQ+ 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 876  ELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAI 935
            +L   M+  ++ELE  +A       +  E E    +L A       ++++++++   A  
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-------DLMQLQEDLAAAER 1701

Query: 936  SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMAD 985
            + K A++   EL+     +     AL+ EK RL  ++ Q      + Q  M+ M+D
Sbjct: 1702 ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757



 Score =  138 bits (347), Expect = 3e-32
 Identities = 189/870 (21%), Positives = 374/870 (42%), Gaps = 126/870 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVK------ESKLSSSMNSIKTFWSPE---------LK 195
            I DLQ Q+ E+  +  L +K+ E++      + +++   N++K     E         L 
Sbjct: 1071 IADLQAQIAELKMQ--LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD 1128

Query: 196  KERALR-KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQ---DSS 251
             ERA R K E  K  + +E   +  E    +  T  A Q ELR +R+      +   D  
Sbjct: 1129 SERAARNKAEKQKRDLGEELEALKTELEDTLDST--ATQQELRAKREQEVTVLKKALDEE 1186

Query: 252  SRTGEPCVAELTEENFQRLHA------EHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
            +R+ E  V E+ +++ Q +        + +R    L   ++TLE+    +  + + L   
Sbjct: 1187 TRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQA 1246

Query: 306  DESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
             + ++   + L+++    ++   D ER R  AE    VH L++   + E    ML E   
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERAR--AELNDKVHKLQN---EVESVTGMLNEAEG 1301

Query: 366  RRFENAPD----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
            +  + A D    S++ +  Q +++ +  +  ++   LR LEEE   L+       ++ +E
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQ-------DQLDE 1354

Query: 422  EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK--- 478
            EM+  +    H   +  ++   K++L    +  E L++     Q EI  + Q+   K   
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414

Query: 479  ----DTELLALQTKLETLTNQFSDSKQHIEVLK------ESLTAKEQR-AAILQTEVDAL 527
                +     LQ +L+ L     + +Q +  L+      + L A+E+  ++    E D  
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474

Query: 528  RLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLK-DMLDVKERKVNVLQKKIENLQEQ 586
                 EKET      + +++  E K         LK +M D+   K +V  K +  L++ 
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-GKNVHELEKS 1533

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLE---EAL-AEKERTIERLKEQRDRDERE 642
             R  E QM  +K +++ L+ +   T+ A   LE   +AL  + ER ++   EQ +   R+
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ 1593

Query: 643  KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIA 702
             Q ++  Y+ +L+D +++ +L      + E  L DL+          L+ DS +K  E A
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLE----------LQADSAIKGREEA 1643

Query: 703  LEQKKEECLKMESQLKKAHEAALEARAS--------PEMSDRIQHLEREITRYKDE---S 751
            ++Q +    K+++Q+K       +ARAS         E   + + LE ++ + +++   +
Sbjct: 1644 IKQLR----KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAA 1699

Query: 752  SKAQAEVDRLLEILKE-----------VENEKNDKDKKIAELERQVKDQNKKVANLKHK- 799
             +A+ + D   E L E           +++EK   + +IA+LE +++++   +  +  + 
Sbjct: 1700 ERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759

Query: 800  ------------EQVEKKKSAQMLEEAR----RREDNLNDSSQQLQDSLRKK-------- 835
                        E   ++ +AQ  E AR    R+   L     +++ +++ K        
Sbjct: 1760 RKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819

Query: 836  DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKL 895
            + +I +LEE + +  +        L Q++        QVE+     E+ K++ E   A++
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879

Query: 896  SSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
               ++ L E E     + A RRK   E+ E
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDE 1909



 Score =  130 bits (326), Expect = 9e-30
 Identities = 191/843 (22%), Positives = 358/843 (42%), Gaps = 138/843 (16%)

Query: 156  TQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK---ERALRKDEASKITIWK 212
            + L+E L      R   E ++  L   + ++KT     L     ++ LR     ++T+ K
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180

Query: 213  EQYRVVQEENQHMQMTIQAL-QDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLH 271
               + + EE +  +  +Q + Q   +   +L +  +Q   ++          ++N Q L 
Sbjct: 1181 ---KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKAN-------LDKNKQTLE 1230

Query: 272  AEHERQAKELFLLRKTLEEME---LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEE 328
             E+   A EL +L +  +E+E    ++E Q Q L ++    ++    L  K    K   E
Sbjct: 1231 KENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK--VHKLQNE 1288

Query: 329  DHERTRRLAEAEMHVHHLE----SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
                T  L EAE     L     SL  Q +    +L+EE  ++      S K + L+   
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNV---STKLRQLEEER 1345

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
                 ++       ++LE  I  L    + S ++ ++    +E      K  + ++E L 
Sbjct: 1346 NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405

Query: 445  EELSSKEAQWEELKKKAAGLQAEIG----------QVKQELSRKDTELLALQTKLETLTN 494
            ++   K A +++L+K    LQ E+           Q+   L +K  +   L  + + +++
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465

Query: 495  QFSDSKQHIEV---------------LKESLTAKEQRAA---ILQTEVD----------- 525
            +++D +   E                L+E+L AKE+      +L+ E++           
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGK 1525

Query: 526  ----------ALRLRLEEKETMLNKKTKQIQDMAEEK-----GTQA--GEIH-DLKDMLD 567
                      AL  ++EE +T L +   ++Q   + K       QA  G+   DL+   +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585

Query: 568  VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN----TDTALTTLEEALA 623
              E K   LQ+++   + +L D+ KQ +      K L+ D  +     D+A+   EEA+ 
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645

Query: 624  EKERTIERLKE-QRD-RDEREKQEEI-----DNYKKDLKDLKEKVSLLQGDLS--EKEAS 674
            +  +   ++K+ QR+  D R  ++EI     +N KK  K L+  +  LQ DL+  E+   
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKK-AKSLEADLMQLQEDLAAAERARK 1704

Query: 675  LLDLK------EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEAR 728
              DL+      E ASSL+     +D + + LE  + Q +EE  + +  ++   +   +A 
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEK-RRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763

Query: 729  ASPEMSDRIQHLEREITRYKDESSKAQAEVDR--LLEILKEVENEKNDKDK--------K 778
               E        ER  T  K+ES++ Q E     L   L E+E     K K        K
Sbjct: 1764 QQAEQLSNELATERS-TAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822

Query: 779  IAELERQVKDQ-NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDD 837
            IA+LE QV+ +  +K A  K  +Q +KK     L+E   + ++    ++Q ++   K + 
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKK-----LKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 838  RIEELEEALRESVQITAEREMVLAQEESARTNA-----EKQVEELLMAMEKVKQELESMK 892
            R+++L+  L E            A+EES R NA     +++++E   + E + +E+ ++K
Sbjct: 1878 RVKQLKRQLEE------------AEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925

Query: 893  AKL 895
            +KL
Sbjct: 1926 SKL 1928



 Score =  127 bits (319), Expect = 6e-29
 Identities = 179/840 (21%), Positives = 363/840 (43%), Gaps = 129/840 (15%)

Query: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
            HLE   + K  +  M  + M R +      AK +   T +++     ++  + LR+ +  
Sbjct: 777  HLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLK-LRNWQWW 835

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
                K    L    +EEEM+  E     +K  + K E   +EL  K +Q  E K      
Sbjct: 836  RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKN----- 890

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAIL 520
                  + QE  + +TEL A   + E +  + +  KQ +E +   + A+    E R   L
Sbjct: 891  ------LLQEQLQAETELYA---EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQL 941

Query: 521  QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKI 580
            Q E   +  ++ + E  L ++    Q +  EK T   +I  L+D + V + + N L K+ 
Sbjct: 942  QAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKER 1001

Query: 581  ENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKEQRD 637
            + L+E++ D    ++  +E+ K+L       ++ ++ LE  L ++E++   +E+LK + +
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061

Query: 638  RDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS---------------------EKEASLL 676
             D  +  E+I + +  + +LK +++  + +L                      E E  + 
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHIS 1121

Query: 677  DLKEHASSLASSGLKKDSRLKTLEIALEQKKEEC--------------LKMESQ---LKK 719
            DL+E   S  ++  K + + + L   LE  K E                K E +   LKK
Sbjct: 1122 DLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKK 1181

Query: 720  A-------HEAALE------ARASPEMSDRIQHLER---EITRYKDESSKAQAEVDRLLE 763
            A       HEA ++      A+A  E++++++  +R    + + K    K  A++   L 
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELR 1241

Query: 764  IL----KEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQVEKKKSAQMLEEARR 816
            +L    +EVE++K   + ++ EL+ +  D  +  A L    HK Q E +    ML EA  
Sbjct: 1242 VLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 817  REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 876
            +   L      L   L+   D  E L+E  R+ + ++ +    L Q E  R + + Q++E
Sbjct: 1302 KAIKLAKDVASLSSQLQ---DTQELLQEETRQKLNVSTK----LRQLEEERNSLQDQLDE 1354

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
             + A + +++ + ++  +LS +++ L +  + +  L   +++  +E+  + Q+       
Sbjct: 1355 EMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ-----YE 1409

Query: 937  EKDANIALLELSSSKKKTQEEVAALKREKD---RLVQQLKQQTQNRMKLMADNYEDDHFK 993
            EK A  A  +L  +K + Q+E+  L  + D   +LV  L+++ +   +L+A   E+ +  
Sbjct: 1410 EKAA--AYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA---EEKNIS 1464

Query: 994  SSHSNQTNHKPSP---------------DQIIQPLLELDQNRSKLKLYIGHLTTLCHDRD 1038
            S ++++ +   +                ++ ++   EL++    LK  +  L +   D  
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524

Query: 1039 PLILRGLTPPASYNLDDDQAAWENELQKMTR--GQLQDELEKGERDNAELQEFANAILQQ 1096
              +         + L+  + A E ++++M     +L+DEL+  E     L+    A+  Q
Sbjct: 1525 KNV---------HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575



 Score =  108 bits (271), Expect = 2e-23
 Identities = 146/643 (22%), Positives = 272/643 (42%), Gaps = 102/643 (15%)

Query: 139  VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKK 196
            V   LRQ  +     LQ QL E +     L + +     +LS S   ++ F S    L++
Sbjct: 1334 VSTKLRQLEEER-NSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 197  ERALRKDEASKITIWKEQ----YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
             +   + E   +T   E+    Y  +++    +Q  +  L  +L  QR L  +   +   
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQL--VSNLEKKQ 1450

Query: 253  RTGEPCVAELTEENFQRLHAEH---------ERQAKELFLLRKTLEEMELRIETQKQT-- 301
            R  +  +AE  E+N    +A+          E++ K L L R   E +E + E ++    
Sbjct: 1451 RKFDQLLAE--EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKM 1508

Query: 302  --------LNARDESIKKLLEMLQSK-GLSAKATE--------EDHERTRRLAEAEMHVH 344
                    ++++D+  K + E+ +SK  L  +  E        ED  +    A+  + V+
Sbjct: 1509 LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVN 1568

Query: 345  ----------HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394
                       L++  EQ E++   L+ ++H       D  K +AL    + K      +
Sbjct: 1569 MQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK------L 1622

Query: 395  ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQW 454
            E  L+DLE     L+++ A+  + REE +KQ+   ++  K  + ++E  +       A  
Sbjct: 1623 EGDLKDLE-----LQADSAI--KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATA 1675

Query: 455  EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
            +E +KKA  L+A++ Q++++L+  +        + E L  + + S      L++     E
Sbjct: 1676 KENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLE 1735

Query: 515  QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN 574
             R A L+ E++  +  +E     + K T+Q + ++ E  T+               +K  
Sbjct: 1736 ARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS-----------TAQKNE 1784

Query: 575  VLQKKIENLQEQLRDKEKQM-SSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
              ++++E   ++LR K  +M  ++K + KS                  +A  E  I +L+
Sbjct: 1785 SARQQLERQNKELRSKLHEMEGAVKSKFKS-----------------TIAALEAKIAQLE 1827

Query: 634  EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
            EQ +++ REKQ    + K+  KD K K  LLQ +   K A     KE A        K +
Sbjct: 1828 EQVEQEAREKQAATKSLKQ--KDKKLKEILLQVEDERKMAE--QYKEQAE-------KGN 1876

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
            +R+K L+  LE+ +EE  ++ +  +K      EA  S E   R
Sbjct: 1877 ARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score =  161 bits (408), Expect = 3e-39
 Identities = 218/1019 (21%), Positives = 455/1019 (44%), Gaps = 155/1019 (15%)

Query: 197  ERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE 256
            E  + ++E +K+ +  +Q +        ++ T +  +D+L  +R +NQL + + S   G 
Sbjct: 1883 ELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLE-ERLMNQLAELNGS--IGN 1939

Query: 257  PC-----------VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR 305
             C           + E   +N ++  +E E + ++L +  KT  E E+R E  ++   A+
Sbjct: 1940 YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQL-VKEKTKVESEIRKEYLEKIQGAQ 1998

Query: 306  DES-----IKKLLEMLQSKGLSAKATEEDHERTR-RLAEAEMHVHHLESLLEQKEKENSM 359
             E       K+L E+L+ K    K  ++D  R + +++  E  V  LE +  + +K+  +
Sbjct: 1999 KEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEI 2058

Query: 360  LREEMHRRFENAPDS-AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
             +E + +  E+   + A+  + + +++   S+ + +      L++E+Q  K +     ++
Sbjct: 2059 TKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQ 2118

Query: 419  REEEMKQM--EVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS 476
            ++E++++   +    H K  KN  E+L           + L+++   L+  IG+++  L+
Sbjct: 2119 KDEDLERRLEQAEEKHLKEKKNMQEKL-----------DALRREKVHLEETIGEIQVTLN 2167

Query: 477  RKDTELLALQTKLETLTNQ---FSDSKQHIE-----VLKESLTAKEQRAAILQTEVDALR 528
            +KD E+  LQ  L++   Q   F+ S   ++     V+ E+   + + +  +Q++ + +R
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227

Query: 529  LRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK-ERKVNVLQKKIENLQEQL 587
            L+ E+  ++L  + +Q+    EE       +   K + + K + +V + QK  + LQ + 
Sbjct: 2228 LK-EDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGEN 2286

Query: 588  RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE---REKQ 644
            ++   Q+   +    S Q +    ++ L +L++ L +   ++E+ KEQ+   E   R+++
Sbjct: 2287 KELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQE 2346

Query: 645  EEIDNYK-------KDLKDLKEKVSLLQGDLSEKE---ASLLDLKEHASSLASSGLKK-- 692
             +I N K        DL+  +E  S L  +++ KE    SLL  KE A  +A + L++  
Sbjct: 2347 ADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQH 2406

Query: 693  DSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESS 752
            D  +K LE  L Q++EE + +E + KKA              D+   L   +   K E+ 
Sbjct: 2407 DKEIKELENLLSQEEEENIVLEEENKKA-------------VDKTNQLMETLKTIKKENI 2453

Query: 753  KAQAEVDRLLEILKEVENEKN------------------DKDKKIAELERQVKDQNKKVA 794
            + +A++D  ++ +  ++N+++                  +KD+ I E   +     +++ 
Sbjct: 2454 QQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR 2513

Query: 795  NLK-HKEQVEKKKSAQMLEEARRRED-----NLNDSSQ------------QLQDSLRKKD 836
             L+ H + +  + +    E  + RED      + DS Q            +L++   K +
Sbjct: 2514 GLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573

Query: 837  DRIEELEEA---LRESVQITAEREMVLAQE-ESARTNAEKQVEELLMAME---------- 882
            ++++E EEA   LR S     E +  L++E ES + +  +   ++    E          
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQ 2633

Query: 883  -KVK-QELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 940
             KVK +E+  + A  SS+Q+ +AE E  L  ++ E  K + E+ +  ++ L       DA
Sbjct: 2634 LKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHL--HHDA 2691

Query: 941  NIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQT 1000
             I    + +  +  +E VA L R+   + Q+L   T+    L A         SS  N  
Sbjct: 2692 GI----MRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSR 2747

Query: 1001 NHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILR----GLTPPASYNLDDD 1056
            +H            ELD+ + K   Y   L  L   ++  +L      L    +++++  
Sbjct: 2748 DHANE---------ELDELKRK---YDASLKELAQLKEQGLLNRERDALLSETAFSMNST 2795

Query: 1057 QAAWENELQKMTRGQLQDELE------KGERDNAELQEFANAI--LQQIADHCPDILEQ 1107
            +    + L+K+ +  L  + +      + E    ++Q F+ A+  LQ   DH  + LE+
Sbjct: 2796 EENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEK 2854



 Score =  144 bits (362), Expect = 6e-34
 Identities = 222/1068 (20%), Positives = 452/1068 (42%), Gaps = 157/1068 (14%)

Query: 139  VPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS--PELKK 196
            V   L+Q  D      Q   +E+  E DLL+K+ E ++ KL +++ + K        L++
Sbjct: 955  VSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEE 1014

Query: 197  ERALRKDEASK-ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTG 255
            E A  KDE+ K I + + +   V+E+ ++ + + + +  + +   ++    +Q  S +  
Sbjct: 1015 ELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQ---EIEIYLKQTISEKEV 1071

Query: 256  EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM 315
            E  +  + ++  ++L AE + QA  +  + +TL++   +I+  +  ++     I+KL+  
Sbjct: 1072 E--LQHIRKDLEEKLAAEEQFQAL-VKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITS 1128

Query: 316  LQ--SKGLSAKATEEDHERTRRLAEAEMHVH-HLESLLEQKEKENSMLREEMHRRFENAP 372
                S G S    +E    +     +  H    LE  +   EKE   L+           
Sbjct: 1129 NTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQ----------- 1177

Query: 373  DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSH 432
                 K LQ  +  + + +   +   R L EE++  K +     E+ +E+ K+ E     
Sbjct: 1178 -----KKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232

Query: 433  SKFMKNKV-EQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLET 491
             + ++ +V E +  +L S + Q  E      GL+  +         K TE    Q  LE+
Sbjct: 1233 LRQLQIQVRESIDGKLPSTDQQ--ESCSSTPGLEEPLF--------KATEQHHTQPVLES 1282

Query: 492  -LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM--LNKKTKQIQDM 548
             L   +    +    L+   +  + +A + + E + + L L+   T   L KK++++  +
Sbjct: 1283 NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQL 1342

Query: 549  AEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN-------------LQEQLRDKEKQMS 595
             E+   Q  EI  LK +    E     LQ+K+E+             LQ +L + +K +S
Sbjct: 1343 QEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLIS 1402

Query: 596  SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ-----RDRDEREKQEEID-- 648
              +E V  L    +  + ALT ++  + E+E  I+ L  Q     ++ DER KQ +++  
Sbjct: 1403 KKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELC 1462

Query: 649  -------------------------------NYKKDLKDLKEKVSLLQGDLSEKEASLLD 677
                                              K+ K L+E++SL +G +     SL D
Sbjct: 1463 EMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLAD 1522

Query: 678  LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-------------SQLKKAHEAA 724
            ++   S +++   +KD+ L  L +  E++ +   +M+               LK A E  
Sbjct: 1523 VE---SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579

Query: 725  LEARASPEMSDRIQHLE----REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
             E +   ++   I+ L+     E T ++++  + Q E + LL+  + V NE     ++I 
Sbjct: 1580 TEDK--EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEA----ERIQ 1633

Query: 781  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
             +   V+ + +++       +  KK++ + L+EA   E  + +  ++++   + K  +I 
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQEA---EQEMEEMKEKMRKFAKSKQQKIL 1690

Query: 841  ELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQ 900
            ELEE          E + + A+   A   A++ +E LL +   +K+ELE +K +     +
Sbjct: 1691 ELEE----------ENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKME----YE 1736

Query: 901  SLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEE--- 957
            +L++K     +L +E+    EEV ++K +  +     K AN+   E   ++    EE   
Sbjct: 1737 TLSKK---FQSLMSEKDSLSEEVQDLKHQ--IEGNVSKQANLEATEKHDNQTNVTEEGTQ 1791

Query: 958  -VAALKREKDRLVQQLKQQ-TQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLE 1015
             +     E+D L    +   +++     + N       SSH    N+    DQ+ + +  
Sbjct: 1792 SIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAG 1851

Query: 1016 LDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDE 1075
            L++ + K K +     TL ++++ L+ +  T      +  ++    N L +  + +L   
Sbjct: 1852 LEEEKQKNKEF---SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908

Query: 1076 LEKGERDNAELQEFANAILQQIAD-------HCPDILE-QVVNALEES 1115
             +  E    E  +    ++ Q+A+       +C D+ + Q+ N L ES
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLES 1956



 Score =  142 bits (359), Expect = 1e-33
 Identities = 220/1084 (20%), Positives = 457/1084 (42%), Gaps = 168/1084 (15%)

Query: 153  DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKT--FWSPELKKERALRKDEASKITI 210
            +LQ  LKE  +E   L+KD    + K+S+   ++K   F   E +K+  + K+  ++   
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068

Query: 211  WKEQ-------YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT 263
             +++       ++V+ ++ Q      + L D L+++++L    +   S    +    E  
Sbjct: 2069 HRKKAQAELASFKVLLDDTQ--SEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126

Query: 264  EENFQRLHAEHERQAKE-LFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK--- 319
             E  +  H + ++  +E L  LR+    +E  I   + TLN +D+ +++L E L S    
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186

Query: 320  --GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT 377
                +   +    +R R + EA+         ++ KE       EE+  + +N     K 
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKE-------EEIRLKEDNC-SVLKD 2238

Query: 378  KALQTVIEMKDSKI--SSMERGLRDLEE----EIQMLKSNGALSTEEREEEMKQMEVYRS 431
            +  Q  I M++ KI  S +E   +  E     E+Q+ +        E +E + Q+E  R 
Sbjct: 2239 QLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298

Query: 432  HSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLET 491
                 +N++ +L+ EL S + Q  +L       + + G ++  + +++ ++   +   E 
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2358

Query: 492  LTNQFSDSKQHIEVLKESLTAKEQRA-AILQTEVDALRLRLEEKETMLNKKTKQIQDM-A 549
            L      S++    L E +  KEQ+  ++L  + +A+++ + E     +K+ K+++++ +
Sbjct: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418

Query: 550  EEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 609
            +E+        + K  +D    K N L + ++ ++++   ++ Q+ S  + + SLQ D  
Sbjct: 2419 QEEEENIVLEEENKKAVD----KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD 2474

Query: 610  NTDTALTTLEEA----LAEKERTIE-------RLKEQ----------RDRDEREKQEEID 648
                    LEE     + EK++ I+       +LKE+           + +  +   E+ 
Sbjct: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534

Query: 649  NYKKDL----------------------KDLKEKVSLLQGDLSEKEASLLDLKEHASSLA 686
             Y++DL                      K+L+ K + L+  L E E +  DL+   ++L 
Sbjct: 2535 QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQ 2594

Query: 687  SSGLKKDSRLKTLEIALEQKKEECLKME---------SQLKKAHEAALEARASPEMSD-R 736
                     +++L++++ Q   +   ++         +QLK   E      A    S  R
Sbjct: 2595 EEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKR 2654

Query: 737  IQHLEREITRYKDESSKAQAEV-DRLLEILKEVE-------NEKNDKDKKIAELERQVKD 788
            I  LE E+   + E++K   E+ D+L + LK +        NE    ++++AEL R + +
Sbjct: 2655 IAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVE 2714

Query: 789  QNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS----SQQLQDSLRKKDDRIEELEE 844
              +K+  +      E K     ++   R   +L +S    +++L +  RK D  ++EL +
Sbjct: 2715 MEQKLLMVTK----ENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ 2770

Query: 845  ALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAE 904
             L+E   +  ER+ +L++   +  + E   E  L  +EK+ Q+L S   +L      L +
Sbjct: 2771 -LKEQGLLNRERDALLSETAFSMNSTE---ENSLSHLEKLNQQLLSKDEQLLHLSSQLED 2826

Query: 905  KETHLTNLRA------ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQ--- 955
                + +           R HL   LE  ++      SE+    +  + S+S  + Q   
Sbjct: 2827 SYNQVQSFSKAMASLQNERDHLWNELEKFRK------SEEGKQRSAAQPSTSPAEVQSLK 2880

Query: 956  EEVAALKREKDRLVQQLK-----------------------QQTQNRMK---LMADNYED 989
            + +++L+ ++DRL+++LK                       Q+ Q++ K   +M +    
Sbjct: 2881 KAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQ 2940

Query: 990  DHFKSSH----------SNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDP 1039
            ++    H          S + + +   +Q +  + + DQ  S L+  I  L +      P
Sbjct: 2941 ENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQP 3000

Query: 1040 LIL---RGLTPPASYNLDDDQ-AAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQ 1095
            L +   R  +P  S + D  Q   +E EL    R QL D L++  +    +Q+  +   Q
Sbjct: 3001 LKVQYQRQASPETSASPDGSQNLVYETEL---LRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057

Query: 1096 QIAD 1099
             + +
Sbjct: 3058 LLEE 3061



 Score =  131 bits (329), Expect = 4e-30
 Identities = 247/1078 (22%), Positives = 445/1078 (41%), Gaps = 225/1078 (20%)

Query: 155  QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ 214
            Q Q +   R + L +K     E K S  ++  KT    EL+      KD+ SK+   K +
Sbjct: 354  QAQAELESRYSALEQKHKAEMEEKTSHILSLQKT--GQELQSACDALKDQNSKLLQDKNE 411

Query: 215  YRVVQEENQHMQMTIQALQDELR-----IQRDLNQL--FQQDSSSRTGEPCVAE-----L 262
              V   +      TIQ L+D+L+     I + LN+L   Q +++S+T  P V       +
Sbjct: 412  QAVQSAQ------TIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAV 465

Query: 263  TEENFQRLH---AEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
            TEEN   L     E E +   L L    LEE           L A +E +   + +L+++
Sbjct: 466  TEENIASLQKRVVELENEKGALLLSSIELEE-----------LKAENEKLSSQITLLEAQ 514

Query: 320  GLSAKATEE-------DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH------- 365
              + +A  E       D    R  +  E     LE+   QK KE S+L  EM        
Sbjct: 515  NRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIA 574

Query: 366  --------RRFENAP----DSAKTKALQ----TVIEMK----------------DSKISS 393
                    +R E A     D  + K ++      I+MK                +S + +
Sbjct: 575  FLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPA 634

Query: 394  MERGLRDLE------EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL 447
            +E+     E      EEI +  +   L + +++ + K +       +  ++++E+LK ++
Sbjct: 635  VEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGD-KSLSAVPDIGQCHQDELERLKSQI 693

Query: 448  SSKEAQW-----------EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQF 496
               E  +           +E  K+ + L   I + K+      +   AL  + + L +Q 
Sbjct: 694  LELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQ- 752

Query: 497  SDSKQHIEVLKESLTAKEQRAAILQTEVDAL------RLRLEEKETMLNKKTKQIQDMAE 550
                     +KE     E RA + Q E++        RL  E +    N  T+QI  ++ 
Sbjct: 753  ---------VKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSI 803

Query: 551  EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 610
            E  ++  +I  L++ LD  + + +     I +LQ QL++KE ++    ERV+ + +    
Sbjct: 804  EAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863

Query: 611  TDTAL-------TTLEEALAEKERTIERLKEQ-RDRDER---------EKQEEIDNYK-- 651
               AL       T +++ L EK+R +E L++   ++D++         EK  +++  K  
Sbjct: 864  LSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFS 923

Query: 652  --KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK--DSRLKTLEIALEQKK 707
               ++K LKE+++LL      K+  + +  E      SSGLK+  D      +I+ E+ +
Sbjct: 924  LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNE-----VSSGLKQNYDEMSPAGQISKEELQ 978

Query: 708  EE--CLKMES-QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK--AQAEVDRLL 762
             E   LK E+ Q K+  +AAL  R   E+  R+  LE E+   KDES K    +E +R  
Sbjct: 979  HEFDLLKKENEQRKRKLQAALINR--KELLQRVSRLEEELANLKDESKKEIPLSETER-- 1034

Query: 763  EILKEVENEKNDKD-------KKIAELERQVKDQ-NKKVANLKH-KEQVEKKKSAQMLEE 813
                EVE +K +K+        K  E+E  +K   ++K   L+H ++ +E+K +A+   +
Sbjct: 1035 ---GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQ 1091

Query: 814  A--RRREDNLNDSSQQ---LQDSLRKKDDRIEEL-----EEALRESVQITAEREMVLAQE 863
            A  ++    L D + Q   LQ  + +    I++L     + +  +SV +  E  ++    
Sbjct: 1092 ALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPC 1151

Query: 864  ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
              +  + + ++EE ++A+EK K++L+    +  ++++++ +K         E+ +HL E 
Sbjct: 1152 TGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKK-------AQEKERHLRE- 1203

Query: 924  LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKRE-----KDRLVQQLKQQTQN 978
             E+KQ        +KD    L E    + K  E +    R+     ++ +  +L    Q 
Sbjct: 1204 -ELKQ--------QKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQ 1254

Query: 979  RMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLC---- 1034
                     E+  FK++  + T          QP+LE               + LC    
Sbjct: 1255 ESCSSTPGLEEPLFKATEQHHT----------QPVLE---------------SNLCPDWP 1289

Query: 1035 -HDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFAN 1091
             H  D   L+G T  A       +   E    ++       EL K   +  +LQE  N
Sbjct: 1290 SHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQIN 1347



 Score =  130 bits (326), Expect = 9e-30
 Identities = 176/858 (20%), Positives = 373/858 (43%), Gaps = 108/858 (12%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
            L++ RD  I    T++   L EN  L    E     L  ++  +       +K+  +L+ 
Sbjct: 1544 LQEERDKLI----TEMDRSLLENQSLSSSCE----SLKLALEGLTEDKEKLVKEIESLKS 1595

Query: 203  DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
             + ++ T W+E+++ +Q+E + +  + + + +E    + + +  +Q+     G+    E 
Sbjct: 1596 SKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEA 1655

Query: 263  ----TEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR----DESIKKLLE 314
                TE+  Q    E E   +++    K+ ++  L +E +   L A      ++ K+ +E
Sbjct: 1656 NKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECME 1715

Query: 315  MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
             L S   S K   E+ ER +   E E      +SL+ +K+  +  +++  H+   N    
Sbjct: 1716 TLLSSNASMK---EELERVKM--EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQ 1770

Query: 375  AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
            A  +A     E  D++ +  E G + +  E +      +LS   R    + +   +S + 
Sbjct: 1771 ANLEAT----EKHDNQTNVTEEGTQSIPGETE---EQDSLSMSTRPTCSESVPSAKSANP 1823

Query: 435  FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
             +        +E+++   Q ++LK++ AGL+ E  Q  +E S+       L+ +  TL +
Sbjct: 1824 AVSKDFSS-HDEINNYLQQIDQLKERIAGLEEE-KQKNKEFSQ------TLENEKNTLLS 1875

Query: 495  QFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL-RLRLEEKETMLNKKTKQIQDMAEEKG 553
            Q S     +++L+E +T        +Q E+  + +L+   +E   + + + +  +AE  G
Sbjct: 1876 QISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNG 1935

Query: 554  TQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
            +      D+ D            Q K E L+ ++++ +K +S L+E  + L  + T  ++
Sbjct: 1936 SIGNYCQDVTDA-----------QIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVES 1984

Query: 614  ALTT--LEEAL-AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE 670
             +    LE+   A+KE   +   ++     +EKQ+E+   +KD    +EK+S L+     
Sbjct: 1985 EIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALE----- 2039

Query: 671  KEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS 730
                                     +K LE    + +++    +  L +A E   +A+A 
Sbjct: 2040 -----------------------RTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQA- 2075

Query: 731  PEMSDRIQHLEREITRYKDESSKAQAEVDRLL-EILKEVENEKNDKDKKIAELERQVKDQ 789
                        E+  +K      Q+E  R+L + LK  +  +++K+   ++++++ +D 
Sbjct: 2076 ------------ELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDL 2123

Query: 790  NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 849
             +++   + K   EKK   + L+  RR + +L ++  ++Q +L KKD  +++L+E L  +
Sbjct: 2124 ERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183

Query: 850  V-QITA-EREMVLAQEESART--NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 905
            V Q+ A  + M   Q++  R    A+K   +   A++  ++E+   +   S  +  L + 
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQM 2243

Query: 906  ETHLTNLR--AERRKHLEEVLEMK-------QEALLAAI--SEKDANIALLELSSSKKKT 954
              H+  L+    R +H +++ E K       Q+ +   +    K+    L E       +
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303

Query: 955  QEEVAALKREKDRLVQQL 972
            Q E+A L+ E   L  QL
Sbjct: 2304 QNELAKLESELKSLKDQL 2321



 Score =  119 bits (297), Expect = 2e-26
 Identities = 207/1079 (19%), Positives = 462/1079 (42%), Gaps = 176/1079 (16%)

Query: 137  STVPHSLRQARDNTIMDLQTQLKEVL----RENDLLRKDVEVKESKLSSSMNSIKTFWSP 192
            S VP  + Q   + +  L++Q+ E+     +  ++  K+++ K  ++S+    I+ F   
Sbjct: 673  SAVP-DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEF--- 728

Query: 193  ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS 252
               K+ A   + +S  T   E+   +  + + + M  +      +++ +L +  +Q    
Sbjct: 729  ---KKNA--DNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLD 783

Query: 253  RTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIK-K 311
               +     L  E    L  E + +  ++ +L+  L++++L+   Q   + +    ++ K
Sbjct: 784  YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNK 843

Query: 312  LLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENA 371
              E+L+        + +  E ++ L++ E+ +  ++ LL +K+++   L++ +  + +  
Sbjct: 844  ESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQV 903

Query: 372  PDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE------MKQ 425
             + + +   + ++++ + K S +   ++ L+E++ +L        E+ EE+      +KQ
Sbjct: 904  TEISFSMT-EKMVQLNEEKFS-LGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961

Query: 426  ------------MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQ 473
                         E  +     +K + EQ K +L +     +EL ++ + L+ E+  +K 
Sbjct: 962  NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021

Query: 474  ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEE 533
            E S+K+  L       ET   +  + K++ E  ++ +T+K Q   I       L+  + E
Sbjct: 1022 E-SKKEIPLS------ETERGEVEEDKENKEYSEKCVTSKCQEIEIY------LKQTISE 1068

Query: 534  KETMLNKKTKQIQD-MAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLR---- 588
            KE  L    K +++ +A E+  QA  +  +   L  K  ++++LQ +I   Q  ++    
Sbjct: 1069 KEVELQHIRKDLEEKLAAEEQFQA-LVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLIT 1127

Query: 589  ---------------------------------DKEKQMSSLKERVKSLQADTTNTDTAL 615
                                             + E+++ +L++  + LQ       T+ 
Sbjct: 1128 SNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSR 1187

Query: 616  TTLEEALAEKERTI-ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ--------- 665
              + +   EKER + E LK+Q+D D    QE+ D   K+ +++ +++  LQ         
Sbjct: 1188 KAILKKAQEKERHLREELKQQKD-DYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDG 1246

Query: 666  ----GDLSEKEASLLDLKE---------HASSLASSGLKKDSRLKTLEIALEQKKEECLK 712
                 D  E  +S   L+E         H   +  S L  D    + + +  Q      +
Sbjct: 1247 KLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQ 1306

Query: 713  MESQLKK--AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 770
            +++QLK+  A +  LE + S   S+  +  E E+ + +++ +K   E++ L  +  E E 
Sbjct: 1307 IKAQLKEIEAEKVELELKVSSTTSELTKKSE-EVFQLQEQINKQGLEIESLKTVSHEAEV 1365

Query: 771  EKNDKDKKIAELERQVK------------DQNKKVANLKHKE------QVEKKKSA--QM 810
                  +K+   + Q+             D+ +K+ + K ++      Q+ +K++A  ++
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKI 1425

Query: 811  LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
              E   +ED +     QL+   ++ D+RI++L+  L E  Q   E    + +E  A+   
Sbjct: 1426 QTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEE----IGEESRAKQQI 1481

Query: 871  EKQVEELLMAMEKVKQELESMKAKLSSTQ-------QSLAEKETHLTNLRAERRKHLEEV 923
            +++++  L++ ++  +E +S++ +LS  +       +SLA+ E+ ++    E+   L   
Sbjct: 1482 QRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGR- 1540

Query: 924  LEMKQEALLAAISEKDANIALLE---LSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRM 980
            L + QE     I+E D +  LLE   LSSS +  +  +  L  +K++LV++++    +++
Sbjct: 1541 LALLQEERDKLITEMDRS--LLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKI 1598

Query: 981  KLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPL 1040
                          S   Q  HK    +  + LL+  +N S     I H+      ++  
Sbjct: 1599 A------------ESTEWQEKHKELQKEY-EILLQSYENVSNEAERIQHVVEAVR-QEKQ 1644

Query: 1041 ILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD 1099
             L G       N            +K T  QLQ+  ++ E    ++++FA +  Q+I +
Sbjct: 1645 ELYGKLRSTEAN------------KKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILE 1691



 Score =  114 bits (285), Expect = 5e-25
 Identities = 188/923 (20%), Positives = 390/923 (42%), Gaps = 130/923 (14%)

Query: 135  MASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPEL 194
            + ST+   L QA+        T+++E +    ++++ ++ KE  +S+    +      + 
Sbjct: 159  LISTLQAQLTQAQAEQPAQSSTEMEEFV----MMKQQLQEKEEFISTLQAQLS-----QT 209

Query: 195  KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQA-----LQDELRIQRDLNQLFQQD 249
            + E+A ++    K   ++ Q R+   E++ +Q+  QA     +Q +LR+   L +  ++ 
Sbjct: 210  QAEQAAQQVVREKDARFETQVRL--HEDELLQLVTQADVETEMQQKLRV---LQRKLEEH 264

Query: 250  SSSRTGEPCVAELTEENF--------------QRLHAEH-------ERQAKELFLLRKTL 288
              S  G   V +L ++                Q++ AEH       E + +E  +L   L
Sbjct: 265  EESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKIL---L 321

Query: 289  EEMELRIETQKQTLNARDESIKKLLEMLQSKG------------LSAKATEEDHERTRRL 336
            E+MEL +  +K + +   E +  LLE  +  G            L  K   E  E+T  +
Sbjct: 322  EKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHI 381

Query: 337  AEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT-KALQTVIEMKDSKISSME 395
               +     L+S  +  + +NS L ++ +   E A  SA+T + L+  ++ K  +IS   
Sbjct: 382  LSLQKTGQELQSACDALKDQNSKLLQDKN---EQAVQSAQTIQQLEDQLQQKSKEISQFL 438

Query: 396  RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKE---------E 446
              L      +Q  ++    S  +   E  Q     + +   K  VE   E         E
Sbjct: 439  NRL-----PLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIE 493

Query: 447  LSSKEAQWEELKKKAAGLQAE--IGQVKQELSR-------KDTELLALQTKLETLTNQFS 497
            L   +A+ E+L  +   L+A+   G+  +E+S              A ++  + L N FS
Sbjct: 494  LEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFS 553

Query: 498  DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAG 557
               + + VL   +   ++  A L+ ++   R    + E +  K+ KQ++           
Sbjct: 554  QKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKV 613

Query: 558  EIHDLKD---MLDVKERKVNVLQKKIENLQEQLRDKEK-QMSSLKERVKSLQADTTNTDT 613
             + D      ++  +E  +  ++K+  + + Q R  E+  ++     +KS + D   + +
Sbjct: 614  FLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLS 673

Query: 614  A-----------LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV- 661
            A           L  L+  + E E    + +E  +++  EK +EI N  + +++ K+   
Sbjct: 674  AVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNAD 733

Query: 662  --SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL-EQKKEECLKMESQLK 718
              S     LSE+   LL   +  S +     +  +++K LE+ L E +++  L  ESQ  
Sbjct: 734  NNSSAFTALSEERDQLLSQVKELSMVT----ELRAQVKQLEMNLAEAERQRRLDYESQ-- 787

Query: 719  KAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
             AH+  L  +    +S   +  + +I   ++E    Q +      +++ ++++  +K+ +
Sbjct: 788  TAHDNLLTEQIH-SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESE 846

Query: 779  IAELERQVKDQNKKVANLKH---KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK 835
            + E   +V+  + KV  L     ++++E  K  Q+L E +R         + LQ ++ +K
Sbjct: 847  VLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKR-------DVETLQQTIEEK 899

Query: 836  DDRIEELEEALRES-VQITAER-----EMVLAQEE-----SARTNAEKQVEELLMAMEKV 884
            D ++ E+  ++ E  VQ+  E+     E+   +E+      A    ++QVEE       +
Sbjct: 900  DQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGL 959

Query: 885  KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            KQ  + M      +++ L  +   L     +R++ L+  L  ++E LL  +S  +  +A 
Sbjct: 960  KQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKE-LLQRVSRLEEELAN 1018

Query: 945  LELSSSKKKTQEEVAALKREKDR 967
            L+  S K+    E    + E+D+
Sbjct: 1019 LKDESKKEIPLSETERGEVEEDK 1041



 Score =  114 bits (284), Expect = 7e-25
 Identities = 168/870 (19%), Positives = 357/870 (41%), Gaps = 85/870 (9%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
            LRQ  D  I +L+  L +   EN +L ++ +    K +  M ++KT     ++++  L  
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDS 2461

Query: 203  DEASKITIWKEQYRVV----QEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
               S  ++  ++ R+V    Q E +H+ + ++  Q       + N+L ++    R+    
Sbjct: 2462 FVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRS---- 2517

Query: 259  VAELTEENFQRLHAEHERQAKELFLLRKTLEE-MELRIETQKQTLNARDESIKKLLEMLQ 317
                   +   L++E+ +   EL   R+ L + + ++   QKQ L  + +  K+L     
Sbjct: 2518 -------HMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYA 2570

Query: 318  SKGLSAKATEEDHERTRRLAEA--------EMHVHHLESLLEQKEKENSMLREEMHRRFE 369
                  K +EE +E  RR   A           +  L+  + Q  ++ + L+EE      
Sbjct: 2571 KLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLY 2630

Query: 370  NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQ---- 425
            +    A+ K  +  +    +  SS ++ + +LEEE+  ++   A    E E+++K+    
Sbjct: 2631 H----AQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKH 2686

Query: 426  ----MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE 481
                  + R+ ++  + +V +L  +L   E +   + K+  GL A+I    + +S     
Sbjct: 2687 LHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNS 2746

Query: 482  LLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKK 541
                  +L+ L  ++  S + +  LKE      +R A+L     ++    E   + L K 
Sbjct: 2747 RDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKL 2806

Query: 542  TKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERV 601
             +Q+    E+    + ++ D  + +    + +  LQ + ++L  +L    K     +E  
Sbjct: 2807 NQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKS----EEGK 2862

Query: 602  KSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKV 661
            +   A  + +   + +L++A++        L+  RDR             K+LK+L+++ 
Sbjct: 2863 QRSAAQPSTSPAEVQSLKKAMSS-------LQNDRDR-----------LLKELKNLQQQY 2904

Query: 662  SLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH 721
              +  +++E       L+E+     +  + ++  L+   ++ + +  + L+ME    + H
Sbjct: 2905 LQINQEITELHPLKAQLQEYQDKTKAFQIMQE-ELRQENLSWQHELHQ-LRMEKSSWEIH 2962

Query: 722  EAALEARASPEMSDR---IQHLEREITRYKDESSKAQ-AEVDRLLEILKEVENEKNDKDK 777
            E  ++ +    +SD+   + HL+  I   +  SS+ Q  +V    +   E     +    
Sbjct: 2963 ERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQN 3022

Query: 778  KIAE---LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834
             + E   L  Q+ D  K++   + + Q      +Q+LEE       L D+SQ L+++ + 
Sbjct: 3023 LVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQH 3082

Query: 835  KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 894
              D +      L + VQ      + +     A               EK     +S   +
Sbjct: 3083 YGDLLNHC-AVLEKQVQELQAGPLNIDVAPGA-------------PQEKNGVHRKSDPEE 3128

Query: 895  LSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA---AISEKDANIALLELSSSK 951
            L   QQS +E +  L N R E  + L ++LE +++  +A   A+S  +  I  LE S   
Sbjct: 3129 LREPQQSFSEAQQQLCNTRQEVNE-LRKLLEEERDQRVAAENALSVAEEQIRRLEHSEWD 3187

Query: 952  KKTQEEVAALKREKDRLVQQLKQQTQNRMK 981
                  + +   ++  L+  L   +  R +
Sbjct: 3188 SSRTPIIGSCGTQEQALLIDLTSNSCRRTR 3217



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 153/806 (18%), Positives = 342/806 (42%), Gaps = 128/806 (15%)

Query: 326  TEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIE 385
            T+ED +   RLA AE  V  L+ ++ QK+ +                   K +ALQ   +
Sbjct: 46   TQEDVQE--RLAYAEQLVVELKDIIRQKDVQLQQ----------------KDEALQEERK 87

Query: 386  MKDSKISSM----ERGLRDLEEEIQMLKSNG--ALSTEEREEEMKQMEVYRSHSKFMKNK 439
              D+KI  +    +  L  L + I+ +K+ G   L TE + EE  Q+  +   S   + +
Sbjct: 88   AADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEE--QLSKHDKSSTEEEME 145

Query: 440  VEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDS 499
            +E++K +L  KE       +  + LQA++ Q + E   + +      T++E    +F   
Sbjct: 146  IEKIKHKLQEKE-------ELISTLQAQLTQAQAEQPAQSS------TEME----EFVMM 188

Query: 500  KQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEI 559
            KQ ++  +E ++  + + +  Q E  A ++ + EK+     + +  +D   +  TQA   
Sbjct: 189  KQQLQEKEEFISTLQAQLSQTQAEQAAQQV-VREKDARFETQVRLHEDELLQLVTQA--- 244

Query: 560  HDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
                D+    ++K+ VLQ+K+E  +E L  + + +  L++ +                  
Sbjct: 245  ----DVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQEL------------------ 282

Query: 620  EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
             A  ++ + + +  +Q + +    +  ++  +++ K L EK+ L   +++E++ S  +L+
Sbjct: 283  TAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMEL---EVAERKLSFHNLQ 339

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 739
            E    L                  EQ  +   ++ES+      +ALE +   EM ++  H
Sbjct: 340  EEMHHLLEQ--------------FEQAGQAQAELESRY-----SALEQKHKAEMEEKTSH 380

Query: 740  LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799
            +       ++  S   A  D+  ++L++   +     + I +LE Q++ ++K+++   ++
Sbjct: 381  ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNR 440

Query: 800  EQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE-----------ELEEALRE 848
              +++ ++A          +     +++   SL+K+   +E           ELEE   E
Sbjct: 441  LPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500

Query: 849  SVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETH 908
            + +++++  ++ AQ  +    A+++V E+ +     K+   + ++     + + ++K   
Sbjct: 501  NEKLSSQITLLEAQNRTG--EADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKE 558

Query: 909  LTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL 968
            L+ L  E ++  EE+  +K +  L     ++A+  +L+    K+   E +A +K      
Sbjct: 559  LSVLLLEMKEAQEEIAFLKLQ--LQGKRAEEADHEVLDQKEMKQMEGEGIAPIK------ 610

Query: 969  VQQLKQQTQNRMKLMADN------YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSK 1022
            ++   + T     LM +        E +   + H ++T+ + S +     L    Q+  K
Sbjct: 611  MKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDK 670

Query: 1023 LKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR-----GQLQDELE 1077
                +  +   CH  +   L+        N    Q  +E  L +  +      QL +E +
Sbjct: 671  SLSAVPDIGQ-CHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFK 729

Query: 1078 KGERDNAE----LQEFANAILQQIAD 1099
            K   +N+     L E  + +L Q+ +
Sbjct: 730  KNADNNSSAFTALSEERDQLLSQVKE 755


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  158 bits (399), Expect = 3e-38
 Identities = 244/1112 (21%), Positives = 449/1112 (40%), Gaps = 200/1112 (17%)

Query: 155  QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQ 214
            Q QL + L++ +   + +  +  +LSSS+   +       +K+ A R+D A ++    E+
Sbjct: 532  QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591

Query: 215  YRVVQEENQHMQMTIQALQDELRIQRD-LNQLFQQDSSSRTGEPCVAELTEENFQRLHAE 273
                  E       ++AL+ E   + + L Q  Q  + +R      A+ +    QR  AE
Sbjct: 592  REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS----AQTSVTQAQREKAE 647

Query: 274  HERQAKELFLLRKTLE-------------EMELRIETQKQTLNARDESIK-KLLEMLQSK 319
              R+ +EL    +T               E++LR E QK T   R    K +L E LQ+ 
Sbjct: 648  LSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707

Query: 320  GLSAKATEEDHERTRR-----LAEAEMHVHHLE----SLLEQKEKENSMLREE-MHRRFE 369
              S K T+   E  +R     L E +  +  L+    SL+EQ ++E   L EE   R+  
Sbjct: 708  KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767

Query: 370  NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
             A      +A Q   E+   +++         E E + L    A +  ER E+ +Q E  
Sbjct: 768  EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEA- 825

Query: 430  RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKL 489
              +    + ++  LKEE      + +E K+K AG+++     + ++SR+  EL  L   L
Sbjct: 826  -QYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIES---HSELQISRQQNELAELHANL 881

Query: 490  ETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDAL----RLRLEEKETMLNKKTK-- 543
                 Q  + +   + L + L+  +++ A    EV  L    R   E++ET   +  K  
Sbjct: 882  ARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941

Query: 544  ------QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL-----------QEQ 586
                  Q + + E++G Q       +  L   ER+   +  ++E L           QE+
Sbjct: 942  ARAGDRQPEWLEEQQGRQ---FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEE 998

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTA------------------LTTLEEALA----E 624
               +E++++ L +     QAD      A                    TL+EALA    E
Sbjct: 999  RGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTE 1058

Query: 625  KERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE------------------------- 659
            KE   + L + R   E  + +E++  ++ +K LKE                         
Sbjct: 1059 KEGKDQELAKLRGL-EAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117

Query: 660  ---KVSLLQGDLSEKEASLLDLKEHASSL-------ASSGLKKDSRLKTLEIALEQKKEE 709
               K+  L+ ++S+ E      +E A SL        +S  ++DS L+TL+  LE+K +E
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177

Query: 710  CLKMESQLKKAHEAALEARASPEMSDRIQ-HLEREITRYKDESSKAQAEVDRLLEILKEV 768
                +S L  A       R   +   + +   + ++ R + E+ +  + +  L E +  +
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237

Query: 769  ENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLND----- 823
              +  +K+ +  EL+R V  +++K   L+ + ++ + ++A     A  R   L +     
Sbjct: 1238 NRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297

Query: 824  ---------SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874
                     +S+ L+  L  + +R EEL + L+   +   ++E  L+  +   T+ +  V
Sbjct: 1298 REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALV 1357

Query: 875  EELLMA---------------------MEKVKQELESMKAKLSSTQ----------QSLA 903
             ELL A                     +E+ KQ    ++A+L   Q          Q +A
Sbjct: 1358 SELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVA 1417

Query: 904  EKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKD----ANIAL----LELSSSKKKTQ 955
            E+E     LRAE+  + E++  +K+   L A   +     AN+      +EL  +++K  
Sbjct: 1418 EQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYV 1477

Query: 956  EEVAALKREKD-RL--VQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQP 1012
            +E+AA++ + + RL  VQ+  Q T   +++M   YE    K               +++ 
Sbjct: 1478 QELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVK---------------VLEE 1522

Query: 1013 LLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQL 1072
                 + R KL   +  L     ++   +        S  L D   A + + QK+   Q 
Sbjct: 1523 RQRFQEERQKLTAQVEQLEVFQREQTKQV-----EELSKKLADSDQASKVQQQKLKAVQA 1577

Query: 1073 Q--DELEKGERDNAELQEFANAILQ--QIADH 1100
            Q  +  ++ +R  A+L E    + Q  Q A+H
Sbjct: 1578 QGGESQQEAQRLQAQLNELQAQLSQKEQAAEH 1609



 Score =  142 bits (358), Expect = 2e-33
 Identities = 178/767 (23%), Positives = 338/767 (44%), Gaps = 140/767 (18%)

Query: 276 RQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRR 335
           R  K+L   R   +E+EL +   ++ L  +D  I  + + +    L             +
Sbjct: 218 RLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLAL----------LNEK 267

Query: 336 LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSME 395
            A + +    LE L ++ E     L E                 L+   ++K  K S M+
Sbjct: 268 QAASPLEPKELEELRDKNESLTMRLHE----------------TLKQCQDLKTEK-SQMD 310

Query: 396 RGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455
           R +  L EE      NG LS + RE        + SH + +++ + +L EE S    +W 
Sbjct: 311 RKINQLSEE------NGDLSFKLRE--------FASHLQQLQDALNELTEEHSKATQEW- 355

Query: 456 ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES------ 509
            L+K+A        Q+++ELS    +   L+ K E L  + S  ++H+  L+++      
Sbjct: 356 -LEKQA--------QLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKG 406

Query: 510 --------LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD 561
                   L   +Q AA L      L+ R+E  ET   ++ +Q   +  E+G    E   
Sbjct: 407 EVLGDVLQLETLKQEAATLAANNTQLQARVEMLET---ERGQQEAKLLAERGHFEEEKQQ 463

Query: 562 LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621
           L  +       +  LQ  I NL +   + E+   +   R   L A   +  + LTTL   
Sbjct: 464 LSSL-------ITDLQSSISNLSQAKEELEQASQAHGAR---LTAQVASLTSELTTLNAT 513

Query: 622 LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE- 680
           + ++++ +  LK+Q    + +  + +   ++  + L+ +V  L   L +KE  L ++ E 
Sbjct: 514 IQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573

Query: 681 -------HASSLASSGLKKDSRLKTLEIALEQ----KKEECLKME---SQLKKAHEAALE 726
                  HA  LA++  ++++ L+  + AL+Q    +KE+  K+E    QL+ A+EA   
Sbjct: 574 QEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDS 633

Query: 727 ARAS--------PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
           A+ S         E+S +++ L+  +   + E  +AQA+V   LE+    E +K  + ++
Sbjct: 634 AQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAE-LELQLRSEQQKATEKER 692

Query: 779 IAELERQVKDQ----NKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRK 834
           +A+ + Q+++Q     + +   K   + EK+++A  LEE +R    L   ++ L +  ++
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752

Query: 835 KDDRIEELEEALRESVQI---------TAEREMV---LAQEESARTNAEKQVEELLMAME 882
           +   +EE E A R+ ++           AE E++   LA+  +A+  AE + E+L+    
Sbjct: 753 ERKELEE-ERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV---- 807

Query: 883 KVKQELESMKAKLSSTQQSLAEK----ETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 938
              +E+ + + +   +QQ  A+     +  L  L+ E  K  +E+ E K++  +A I   
Sbjct: 808 ---KEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEK--VAGIESH 862

Query: 939 DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMAD 985
                  EL  S++  Q E+A L     R +QQ++++     KL  D
Sbjct: 863 S------ELQISRQ--QNELAELHANLARALQQVQEKEVRAQKLADD 901



 Score =  127 bits (320), Expect = 4e-29
 Identities = 198/946 (20%), Positives = 393/946 (41%), Gaps = 123/946 (13%)

Query: 201  RKDEASKITIWKEQYRVVQEENQHMQMTIQALQD---------ELRIQRDLNQL------ 245
            +++EA    +++EQ   ++EE +  +  +Q  ++         EL+I R  N+L      
Sbjct: 821  QQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHAN 880

Query: 246  ----FQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRI-ETQKQ 300
                 QQ          +A+      +++ A  +  A+   L+RK  E+ E    E  K+
Sbjct: 881  LARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKE 940

Query: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLE----SLLE---QK 353
               A D   + L E    +  S +A  +  ER     EAE   + LE    +L+E   Q+
Sbjct: 941  PARAGDRQPEWLEEQQGRQFCSTQAALQAMER-----EAEQMGNELERLRAALMESQGQQ 995

Query: 354  EKENSMLREEMHR----RFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLK 409
            ++E      E+ R    R     D A  KA +  +EM+      ++  L +   E   L+
Sbjct: 996  QEERGQQEREVARLTQERGRAQADLALEKAARAELEMR------LQNALNEQRVEFATLQ 1049

Query: 410  SNGALSTEEREEEMKQMEVYRS-------HSKFMKNKVEQLKEELSSKE---AQWEELKK 459
               A +  E+E + +++   R          + ++  V+QLKE+L+ KE   A     + 
Sbjct: 1050 EALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109

Query: 460  KAAG-----------LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKE 508
            +AAG           L+AE+ +++Q+  ++  +  +L+  LE      ++    +E L+ 
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169

Query: 509  SLTAKEQRA-------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHD 561
             L  K Q         A  Q E+ A R ++++     ++   Q+    +E   +   I  
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229

Query: 562  LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA 621
            L++ + +  R+V   + + + L+  +  + ++   L+ER++ LQA+T +          A
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSA 1289

Query: 622  LAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK-E 680
            L E+ +++    E++       ++E+ +  +  ++L +++   Q    +KE +L  L+ E
Sbjct: 1290 LREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLE 1349

Query: 681  HAS--SLASSGLKKD---SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSD 735
            H S  +L S  L       +L+  + A E++  E L+   Q      A L  RA  E+ +
Sbjct: 1350 HTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAEL-LRAQRELGE 1408

Query: 736  RI-------------QHLEREITRYKD-------------ESSKAQAEVDRLLEILKEVE 769
             I             Q L  E   Y +             E ++   E   L     EVE
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVE 1468

Query: 770  NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQ 829
             ++  ++K + EL     D   ++A ++ + Q   ++   M  +    +  + +  Q+ Q
Sbjct: 1469 LDQ-AREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQ 1527

Query: 830  DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
            +  +K   ++E+LE   RE  +   E    LA  + A    +++++ +     + +QE +
Sbjct: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587

Query: 890  SMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSS 949
             ++A+L+  Q  L++KE       AE  K   E  +   +A      +K  N  L E   
Sbjct: 1588 RLQAQLNELQAQLSQKEQ-----AAEHYKLQMEKAKTHYDA------KKQQNQELQEQLR 1636

Query: 950  SKKKTQEEVAALKREKDRLVQQLKQ------QTQNRMKLMADNYEDDHFKSSHSNQTNHK 1003
            S ++ Q+E   L+ E +RL  +L+Q      + +   + +         + +H++Q    
Sbjct: 1637 SLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRD 1696

Query: 1004 PSPDQIIQPLLELDQNRSK--LKLYIGHLTTLCHDRDPLILRGLTP 1047
                Q+    L+  + ++K  L L I  L   C +  PL +    P
Sbjct: 1697 LGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLP 1742



 Score =  122 bits (305), Expect = 2e-27
 Identities = 126/565 (22%), Positives = 268/565 (47%), Gaps = 40/565 (7%)

Query: 448 SSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL- 506
           + +E ++ EL+K A+             S     L   Q ++  L  Q +D + + + L 
Sbjct: 175 AKREIRFLELQKVASSSSGNNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELE 234

Query: 507 ------KESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
                 ++ LT K+ + A++Q  +D L L L EK+     + K+++++ ++  +    +H
Sbjct: 235 LELAENRKLLTEKDAQIAMMQQRIDRLAL-LNEKQAASPLEPKELEELRDKNESLTMRLH 293

Query: 561 D-LKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE 619
           + LK   D+K  K + + +KI  L E+  D   ++      ++ LQ          +   
Sbjct: 294 ETLKQCQDLKTEK-SQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKAT 352

Query: 620 EALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD-- 677
           +   EK+  +E+      +D++  +E+ +  +  L  L+E +S LQ +  +++  +L   
Sbjct: 353 QEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV 412

Query: 678 -----LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE 732
                LK+ A++LA++  +  +R++ LE    Q++ + L      ++ H    + + S  
Sbjct: 413 LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLA-----ERGHFEEEKQQLSSL 467

Query: 733 MSDRIQHLEREITRYKDESSKA-QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
           ++D +Q     +++ K+E  +A QA   RL   +  + +E       +  L   ++ Q++
Sbjct: 468 ITD-LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSE-------LTTLNATIQQQDQ 519

Query: 792 KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
           ++A LK + + ++ + AQ L++  +    L    +QL  SL++K+ +++E+ E    + Q
Sbjct: 520 ELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQ 579

Query: 852 ITAEREMVLAQEESARTNAEKQVEELLMAMEKVK-QELESMKAKLSSTQQSLAEKETHLT 910
             A++    A+E  A         + L A+EK K  +LE ++ +L    ++    +T +T
Sbjct: 580 DHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVT 639

Query: 911 NLRAERRKHLEEVLEMKQ--EALLAAISEKDANIALLEL---SSSKKKTQEEVAALKREK 965
             + E+ +   +V E++   E       E  A +A LEL   S  +K T++E  A  +EK
Sbjct: 640 QAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVA--QEK 697

Query: 966 DRLVQQLKQQTQNRMKLMADNYEDD 990
           D+L +QL Q  +  +K+   + E++
Sbjct: 698 DQLQEQL-QALKESLKVTKGSLEEE 721



 Score =  118 bits (295), Expect = 4e-26
 Identities = 195/898 (21%), Positives = 378/898 (42%), Gaps = 123/898 (13%)

Query: 193  ELKKERALRKDEASKITIWKEQYRVVQEENQHMQMT------IQALQDE-----LRIQRD 241
            EL + R L  ++ ++I + +++   +   N+    +      ++ L+D+     +R+   
Sbjct: 236  ELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHET 295

Query: 242  LNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEM-ELRIETQKQ 300
            L Q     +     +  + +L+EEN   L  +    A  L  L+  L E+ E   +  ++
Sbjct: 296  LKQCQDLKTEKSQMDRKINQLSEENGD-LSFKLREFASHLQQLQDALNELTEEHSKATQE 354

Query: 301  TLNARDESIKKLLEMLQSKGLSAKATEEDHERTR-RLAEAEMHVHHLESLLEQKEKE--N 357
             L  + +  K+L   LQ K    K  EE +E  + +L++ E H+  L+    Q++ E   
Sbjct: 355  WLEKQAQLEKELSAALQDK----KCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLG 410

Query: 358  SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR----DLEEEIQMLKS--- 410
             +L+ E  ++ E A  +A    LQ  +EM +++    E  L       EEE Q L S   
Sbjct: 411  DVLQLETLKQ-EAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLIT 469

Query: 411  ---NGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAE 467
               +   +  + +EE++Q    ++H   +  +V  L  EL++  A  ++  ++ AGL+ +
Sbjct: 470  DLQSSISNLSQAKEELEQAS--QAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQ 527

Query: 468  I----GQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES------------LT 511
                  Q+ Q L +++     L+ ++E L++     +Q ++ + E              T
Sbjct: 528  AKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLAT 587

Query: 512  AKEQRAAILQTEVDALRLRLE----EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLD 567
            A E+R A L+ E DA   +LE    EK   L    +Q+Q   E + +    +   +    
Sbjct: 588  AAEEREASLR-ERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKA 646

Query: 568  VKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA----------LTT 617
               RKV  LQ  +E  +++  + + Q++ L+ +++S Q   T  +            L  
Sbjct: 647  ELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706

Query: 618  LEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLD 677
            L+E+L   + ++E  K +      E+Q  I   K + + L E+    + +L E+ A    
Sbjct: 707  LKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766

Query: 678  LKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRI 737
            L+     L  +  + ++ +   E+A     +   + E +      AA   R      +  
Sbjct: 767  LEARLQQLGEAH-QAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEA 825

Query: 738  QH---LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVA 794
            Q+    + ++   K+E  KA+ E+    E +  +E+            E Q+  Q  ++A
Sbjct: 826  QYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHS----------ELQISRQQNELA 875

Query: 795  NLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES--VQI 852
             L         ++ Q ++E   R   L D    LQ+ +      +  LE  +R++   Q 
Sbjct: 876  EL----HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQE 931

Query: 853  TAEREMVLAQEESARTNAEKQVEEL--------------LMAMEK----VKQELESMKAK 894
            TA RE+V   +E AR   ++Q E L              L AME+    +  ELE ++A 
Sbjct: 932  TASRELV---KEPARA-GDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAA 987

Query: 895  LSST----QQSLAEKETHLTNLRAER-RKHLEEVLEMKQEA-----LLAAISEKDANIAL 944
            L  +    Q+   ++E  +  L  ER R   +  LE    A     L  A++E+    A 
Sbjct: 988  LMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFAT 1047

Query: 945  LELS-----SSKKKTQEEVAALKREKDRLVQQLKQ--QTQNRMKLMADNYEDDHFKSS 995
            L+ +     + K+   +E+A L+  +   +++L++  QT  ++K      E +H   S
Sbjct: 1048 LQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGS 1105


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score =  154 bits (388), Expect = 6e-37
 Identities = 186/880 (21%), Positives = 382/880 (43%), Gaps = 82/880 (9%)

Query: 145  QARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP----ELKKERAL 200
            +A D   ++L  QL+E  R+ + L+  VE  E  ++     + T        EL+K+ AL
Sbjct: 418  EAADREKVELLNQLEEEKRKVEDLQFRVE--EESITKGDLEVATVSEKSRIMELEKDLAL 475

Query: 201  RKDEASKITIWKEQYRVVQEENQHMQMT--IQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
            R  E +++    E  +   + +  + +   I +LQ++L + R  +Q  ++ +S +     
Sbjct: 476  RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ--REITSLKEHFGA 533

Query: 259  VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR----IETQKQTLNARDESIKKLLE 314
              E  ++  + L+   E+ +KE   L+  LE         I   K  L     S ++ +E
Sbjct: 534  REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 593

Query: 315  MLQ---SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH------ 365
             L+   SKGL  +  E    +T+       + H +E+L  Q++ E +   +EM       
Sbjct: 594  ELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 653

Query: 366  ----RRFENAPDSAKTKAL----QTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
                +  EN+ ++ ++K      Q ++EM+D+     E  ++  E E+   K N      
Sbjct: 654  MKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVI 713

Query: 418  ER--------EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIG 469
            +         EE++  ++  R  S   K+++++L+++L + E Q + L+ +     ++  
Sbjct: 714  DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKAS 773

Query: 470  QVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRL 529
             + +EL  ++ +L  LQ  L  ++      ++ +++LKE      + A  +Q  +     
Sbjct: 774  SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 833

Query: 530  RLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRD 589
            +L +KE   N  +  ++ + E       +  +  +  +   +    L+  I  + +   D
Sbjct: 834  KLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGD 893

Query: 590  KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 649
               Q++ + + ++  + D       LT   E  +  +++IE   +   + E+ +QE    
Sbjct: 894  NSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE---DMTVKAEQSQQEAAKK 950

Query: 650  YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
            ++++ K+L+ K+S L+  +        +LK       S     +++ K  EI L+  ++ 
Sbjct: 951  HEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS-----ETKTKHEEI-LQNLQKT 1004

Query: 710  CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
             L  E +LK A E         E S  +Q LE E+ +  D++  AQ   D  ++I++++ 
Sbjct: 1005 LLDTEDKLKGARE---------ENSGLLQELE-ELRKQADKAKAAQTAED-AMQIMEQMT 1053

Query: 770  NEKND-----KDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA-----QMLEEARRRED 819
             EK +     +D K    + Q +    K  NLK+ E++ K K       Q +EE R+  +
Sbjct: 1054 KEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE 1113

Query: 820  NLNDSSQQLQDSLRK-KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 878
             L  ++ Q    L   +++ ++  EE  R   ++T+ +++     E  R+    Q+ E+ 
Sbjct: 1114 TLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL-----EEERSVLNNQLLEMK 1168

Query: 879  MAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEK 938
                K  ++ +  KA L   Q+S++     LT   AE  K   EV  ++ E      S K
Sbjct: 1169 KRESKFIKDADEEKASL---QKSISITSALLTEKDAELEKLRNEVTVLRGE----NASAK 1221

Query: 939  DANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQN 978
              +  +  L S K K + +V  L+ +     +QL   + N
Sbjct: 1222 SLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1261



 Score =  118 bits (296), Expect = 3e-26
 Identities = 161/794 (20%), Positives = 343/794 (43%), Gaps = 131/794 (16%)

Query: 115  SSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
            S G+ ++T  F E       M     H +   ++    +     KE+      L K ++ 
Sbjct: 600  SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 659

Query: 175  KESKLSSSMNSIKTFWSPEL-KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ 233
            KE+ L +  + +       L + E  L K + ++I +  ++  V+Q +       I    
Sbjct: 660  KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV--KELEVLQAKCNEQTKVIDNFT 717

Query: 234  DELRIQR----DLNQLFQQDSSSRTGEPCV---AELTEENFQRLHAEHERQAKELFLLRK 286
             +L+       DL+ L +  S  ++    +    E  E+  + L  E   ++ +   + +
Sbjct: 718  SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777

Query: 287  TLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHV 343
             L+  EL++   ++ L+      E+++K L++L+ K   A+A+EE     R + E    +
Sbjct: 778  ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK--FAEASEEAVSVQRSMQETVNKL 835

Query: 344  HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEE 403
            H       QKE++ +ML  ++ +  EN  D      ++     KD +   + +    LE 
Sbjct: 836  H-------QKEEQFNMLSSDLEKLRENLAD------MEAKFREKDEREEQLIKAKEKLEN 882

Query: 404  EI------------QMLKSNGALSTEEREEEMKQMEVYRS--HSKFMKNKVEQL--KEEL 447
            +I            Q+ K N  L  +ER+ E  Q+++ ++  ++ F++  +E +  K E 
Sbjct: 883  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 942

Query: 448  SSKEA--QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI-E 504
            S +EA  + EE KK+   L+ ++  +++++     +   L+ + E  T++     + I +
Sbjct: 943  SQQEAAKKHEEEKKE---LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999

Query: 505  VLKESLT--------AKEQRAAILQTEVDALRLRLEE-------------KETMLNKKTK 543
             L+++L         A+E+ + +LQ E++ LR + ++              E M  +KT+
Sbjct: 1000 NLQKTLLDTEDKLKGAREENSGLLQ-ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058

Query: 544  QIQDMAEEKGTQA-----------------GEIHDLKDMLDVKERKVNVLQKKIENLQEQ 586
             +  + + K T A                  E++  K++L V+ +K+   +K+IE L++ 
Sbjct: 1059 TLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1118

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 646
               K +Q+S+L+E    L  +   +   +T+ ++   E+ER++  L  Q    ++ + + 
Sbjct: 1119 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSV--LNNQLLEMKKRESKF 1174

Query: 647  IDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 706
            I +  ++   L++ +S+    L+EK+A L  L+   + L      +++  K+L   ++  
Sbjct: 1175 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG----ENASAKSLHSVVQTL 1230

Query: 707  KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 766
            + + +K+E ++K                    +LE ++   K + S +    D       
Sbjct: 1231 ESDKVKLELKVK--------------------NLELQLKENKRQLSSSSGNTD------- 1263

Query: 767  EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA-RRREDNLNDSS 825
                 + D+D++    E Q+   N  + +L+ K Q  K K   M E A     D+LN+  
Sbjct: 1264 ----TQADEDERAQ--ESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1317

Query: 826  QQLQDSLRKKDDRI 839
               Q+   KK  R+
Sbjct: 1318 SDDQEKQSKKKPRL 1331



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 163/801 (20%), Positives = 337/801 (42%), Gaps = 124/801 (15%)

Query: 372  PDSAKTKALQTVI-----EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
            P  AK  A++ V+      +K S  +S    +  +   +    S   L TE      +++
Sbjct: 288  PAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347

Query: 427  EVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK----DTEL 482
                +  + +K K + +++ L+ ++ +  E+ K  +     +G+++QEL+      D  +
Sbjct: 348  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATS----HVGEIEQELALARDGHDQHV 403

Query: 483  LALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKT 542
            L L+ K++ L      + +    L   L  ++++   LQ  V+   +   + E     + 
Sbjct: 404  LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK 463

Query: 543  KQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV-----LQKKIENLQEQLR----DKEKQ 593
             +I ++ ++   +  E+ +L+  L+  +   +V     L ++I +LQE+L     D +++
Sbjct: 464  SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 523

Query: 594  MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKD 653
            ++SLKE   + +        AL T  E L+++    E LK + +   +E  + I  +K  
Sbjct: 524  ITSLKEHFGAREETHQKEIKALYTATEKLSKEN---ESLKSKLEHANKENSDVIALWK-- 578

Query: 654  LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKM 713
                    S L+  ++  + ++ +LK   S        K    +T E A  + + E +++
Sbjct: 579  --------SKLETAIASHQQAMEELKVSFS--------KGLGTETAEFAELKTQIEKMRL 622

Query: 714  ESQLKKAHEAALEARASPEMSDRIQHL-EREITRYKDESSKAQAEVDRLLEILKEVENEK 772
            + Q    HE  +E   + + S+R  H  E E  R K            L++++KE EN  
Sbjct: 623  DYQ----HE--IENLQNQQDSERAAHAKEMEALRAK------------LMKVIKEKENSL 664

Query: 773  NDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSL 832
                 K+ + E Q   + +   N K +E   K K  ++L+     +  + D+       L
Sbjct: 665  EAIRSKLDKAEDQHLVEMEDTLN-KLQEAEIKVKELEVLQAKCNEQTKVIDN---FTSQL 720

Query: 833  RKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK 892
            +  ++++ +L+   + S +  +E + +  Q E+A    EKQ++ L     ++++  ES K
Sbjct: 721  KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA----EKQIKHL-----EIEKNAESSK 771

Query: 893  AKLSSTQQSLAEKETHLTNLRAERRK--HLEEVLEMKQEALLAAISEKDANIALLE---- 946
            A  SS  + L  +E  LTNL+    +   ++E LE + + L    +E       ++    
Sbjct: 772  A--SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQ 829

Query: 947  ---------------LSSSKKKTQEEVAALK---REKDRLVQQL---KQQTQNR----MK 981
                           LSS  +K +E +A ++   REKD   +QL   K++ +N     MK
Sbjct: 830  ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMK 889

Query: 982  LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLI 1041
            +  DN         +      +   +++   L + ++N S L+  I  +T          
Sbjct: 890  MSGDN--SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ--- 944

Query: 1042 LRGLTPPASYNLDDDQAAWENELQKM------TRGQLQDELEKGERDNAELQEFANAILQ 1095
                   A+   ++++   E +L  +      +  Q Q+   + ER  +E +     ILQ
Sbjct: 945  -----QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999

Query: 1096 QIADHCPDILEQVVNALEESS 1116
             +     D  +++  A EE+S
Sbjct: 1000 NLQKTLLDTEDKLKGAREENS 1020


>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
          Length = 1498

 Score =  152 bits (384), Expect = 2e-36
 Identities = 191/868 (22%), Positives = 377/868 (43%), Gaps = 110/868 (12%)

Query: 146  ARDNTIMDL-------QTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPEL---K 195
            ++DNT+ DL       Q+QL++V  E   L   ++  ++++SS + S++ ++  +L   +
Sbjct: 528  SKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISS-LQSVRQWYQQQLALAQ 586

Query: 196  KERALRKDEASKITIWK------------EQYRVVQE--ENQHMQMTIQA-----LQDEL 236
            + R   + E + I + +            E   + Q+  E QH  M  +      LQ   
Sbjct: 587  EARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIE 646

Query: 237  RIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIE 296
                D    F Q   ++T       + EE+ QR   E E + + L  +  +   +E ++E
Sbjct: 647  ADMLDQEAAFMQIQEAKT-------MVEEDLQRRLEEFEGERERLQRMADSAASLEQQLE 699

Query: 297  TQKQTLNARDESIKKL----LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
              K TL  RD+ ++ L    L++++   L+ +A +    R + L   + H   L++ L +
Sbjct: 700  QVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQS---REQSLDALQTHYDELQARLGE 756

Query: 353  KEKENSMLREEMHRRFENAPD--SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
             + E +  RE+     +N      A  +A ++  E  D     +E G  +  E ++ L+ 
Sbjct: 757  LQGEAAS-REDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLRE 815

Query: 411  NGALST-------EEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAG 463
              A+ +       +E     KQM+  +      K  VE  + + +SK+    ELK     
Sbjct: 816  ELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKR 875

Query: 464  LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            L +E+ +++QEL +   E    + +L  L  + +  +QH+  L+  L + ++    ++T 
Sbjct: 876  LDSELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETH 935

Query: 524  VDALRLRLE------EKETMLNKKTKQIQDMAEEKGT-QAGEIHDLKDMLDVKERKVNVL 576
            + +L+   E      E    L K+ +++Q  A +  T Q  ++  L   L   ++++   
Sbjct: 936  LQSLQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTK 995

Query: 577  QKKIEN--------LQEQLRDKEKQMS----------------SLKERVKSLQADTTNTD 612
             K  EN        LQE L  KE   +                +L ER+++L+A+     
Sbjct: 996  HKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQALEAELQAVS 1055

Query: 613  TALTTLEEALAEK-ERTIERLKEQRDR--DEREKQEEIDNYKKDLKDLKEKVSLLQGDLS 669
             + T LE+ L E    T + L+E R++  +  ++ +E   ++K +K L+E    L  +L 
Sbjct: 1056 HSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESNKKLALELE 1115

Query: 670  EKEASLLDL-------KEHASSLASSGLKKDSRLKTLEIALE---QKKEECLKMESQLKK 719
             ++  L  L       +EH S L ++  K+++ L  L + ++   Q+KEE  +    L +
Sbjct: 1116 HEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQ 1175

Query: 720  AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
            A +A+LE        +++  L+ ++   K E+   +         L EV+ E   K+  +
Sbjct: 1176 ALQASLEKE-----KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKELQAKEHLV 1230

Query: 780  AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
             +L+ +  D   ++   KH +++     AQ   E       L    +QL + L K+    
Sbjct: 1231 QKLQAEADDL--QIREGKHSQEI-----AQFQAELAEARAQLQLLQKQLDEQLSKQPVGN 1283

Query: 840  EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 899
            +E+E    E  Q   E + +  Q +       K++E L   ++ VK ELE  +  LS TQ
Sbjct: 1284 QEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQEDLSMTQ 1343

Query: 900  QSLAEKETHLTNLRAERRKHLEEVLEMK 927
            +     +  ++ L+   +  L++  ++K
Sbjct: 1344 KDKFMLQAKVSELKNNMKTLLQQNQQLK 1371



 Score =  137 bits (346), Expect = 4e-32
 Identities = 190/953 (19%), Positives = 402/953 (42%), Gaps = 149/953 (15%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
            +R  RD+    +  +      + ++L+  V  ++ +L   + ++    S  LK++  L+ 
Sbjct: 383  VRSRRDSICSSVSLESSAAETQEEMLQ--VLKEKMRLEGQLEALSLEASQALKEKAELQA 440

Query: 203  DEASKITIWKEQYRVVQEENQHMQMTI-------QALQDELRIQRDLNQLFQQDSSSRTG 255
              A+  T  + Q        Q             Q+  D  R   DL  + +  ++S   
Sbjct: 441  QLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLAS 500

Query: 256  EPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELR---IETQKQTLNARDESIKKL 312
                 ++ EE +QRL A+ E   + +     T+ ++  +   +++Q Q +     ++   
Sbjct: 501  SNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSK 560

Query: 313  LEMLQSKGLSAKATEEDHERTRRLA-EAEMHVH----HLE-------SLLEQKEKENSML 360
            L+  Q++  S ++  + +++   LA EA + +     H++        LLE  + EN  L
Sbjct: 561  LKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSL 620

Query: 361  REEMHRRFENAPDSAKTKA-LQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER 419
             +++    E    S K K  +   ++  ++ +   E     ++E   M++ +     EE 
Sbjct: 621  SQQLT---ETQHRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEF 677

Query: 420  EEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
            E E ++++     +  ++ ++EQ+K  L  ++ Q E L+++   L  ++   ++ L  ++
Sbjct: 678  EGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSRE 737

Query: 480  TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
              L ALQT  + L  +  +       L+    ++E    +LQ E   L   L+  ++   
Sbjct: 738  QSLDALQTHYDELQARLGE-------LQGEAASREDTICLLQNEKIILEAALQAAKSGKE 790

Query: 540  KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
            +  +  + + E     +  +  L++ L +K  +V  LQ++   L++Q++  ++Q    K 
Sbjct: 791  ELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV 850

Query: 600  RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR------DEREKQEEIDNYKKD 653
             V++ + D T+ D  ++ L+   A ++R    LKE R        ++R  + E+    ++
Sbjct: 851  MVEAYRRDATSKDQLISELK---ATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHRE 907

Query: 654  LKDLKEKVSLLQGDLSEKEASLLDLKEHASSL------------ASSGLKK--DSRLKTL 699
            +  +++ ++ L+G L   +    +++ H  SL            A+  LKK  +   +  
Sbjct: 908  VAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQEA 967

Query: 700  EIALEQKKEECLKMESQL----------KKAHEAAL--------EARASPEMSD------ 735
              A+ ++K++  ++ S L           KA+E A+        EA A+ E +D      
Sbjct: 968  RKAITEQKQKMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQL 1027

Query: 736  ---------------RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIA 780
                           RIQ LE E+       +  + E   L E++     E  +  +K+ 
Sbjct: 1028 RAQGGSSDSSLALHERIQALEAELQAVSHSKTLLEKE---LQEVIALTSQELEESREKVL 1084

Query: 781  ELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE 840
            ELE ++++       +K  E+   KK A  LE  + +   L  S+  L     ++ + I 
Sbjct: 1085 ELEDELQESRGFRKKIKRLEE-SNKKLALELEHEKGKLTGLGQSNAAL-----REHNSIL 1138

Query: 841  ELEEALRES--VQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMK------ 892
            E   A RE+  VQ+  + + VL ++E      +  V+ L  ++EK K+++ S+K      
Sbjct: 1139 ETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAA 1198

Query: 893  ---------------AKLSSTQQSLAEKETHLTNLRAE-------RRKHLEEVLEMKQEA 930
                            +LS  ++ L  KE  +  L+AE         KH +E+ + + E 
Sbjct: 1199 KVEAGHNRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAE- 1257

Query: 931  LLAAISEKDANIALLELSSSKKKTQEEVAALKRE--------KDRLVQQLKQQ 975
                ++E  A + LL+    ++ +++ V   + E        K+R +Q LKQQ
Sbjct: 1258 ----LAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQ 1306



 Score =  104 bits (260), Expect = 4e-22
 Identities = 143/651 (21%), Positives = 274/651 (42%), Gaps = 91/651 (13%)

Query: 121  DTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESK-- 178
            DTI   ++    +  A     S ++  D     L+   +E     + LR+++ +K  +  
Sbjct: 766  DTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKSGQVE 825

Query: 179  --------LSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQ 230
                    L   M  IK  +  +     A R+D  SK  +  E           ++ T +
Sbjct: 826  HLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISE-----------LKATRK 874

Query: 231  ALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ-RLH-AEHERQAKELFLLRKTL 288
             L  EL+  R   +L Q     RT E  ++ L  E  Q R H A+ E   +     +K  
Sbjct: 875  RLDSELKELRQ--ELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSA---QKER 929

Query: 289  EEMELRIET------QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL------ 336
            +EME  +++      Q   +   +E++KK +E LQ +  + KA  E  ++ RRL      
Sbjct: 930  DEMETHLQSLQFDKEQMVAVTEANEALKKQIEELQQE--ARKAITEQKQKMRRLGSDLTS 987

Query: 337  AEAEMHVHHLE-----SLLEQKEKENSMLRE----EMHRRFENAPDSAKTKALQTVIEMK 387
            A+ EM   H        +L ++ +E    +E    E+ +       S  + AL   I+  
Sbjct: 988  AQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSSDSSLALHERIQAL 1047

Query: 388  DSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL 447
            ++++ ++      LE+E+Q + +  +   EE  E++ ++E     S+  + K+++L+E  
Sbjct: 1048 EAELQAVSHSKTLLEKELQEVIALTSQELEESREKVLELEDELQESRGFRKKIKRLEESN 1107

Query: 448  SSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLK 507
                 + E  K K  GL      +++  S  +T L   +  L  L  Q          ++
Sbjct: 1108 KKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQ----------VQ 1157

Query: 508  ESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKG-------TQAGEIH 560
              L  KE+    ++  V AL+  LE+++  +N   +Q+     E G         + E+ 
Sbjct: 1158 AVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAASLELS 1217

Query: 561  DLKDMLDVKERKVNVLQKKIENLQ--------------EQLRDKEKQMSSLKERVKSLQA 606
            ++K  L  KE  V  LQ + ++LQ               +L +   Q+  L++++    +
Sbjct: 1218 EVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLS 1277

Query: 607  DTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQG 666
                 +  +  L+  + +KER I+ LK+Q D  E++ ++E++  ++ L+++K ++ + Q 
Sbjct: 1278 KQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSELEMAQE 1337

Query: 667  DLSEK-------EASLLDLKEHASSLASSG--LKKDSRLKTLEIALEQKKE 708
            DLS         +A + +LK +  +L      LK D R    +   E K E
Sbjct: 1338 DLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGE 1388



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 69/358 (19%), Positives = 146/358 (40%), Gaps = 66/358 (18%)

Query: 157  QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYR 216
            ++K +   N  L  ++E ++ KL+    S           E AL K EA  + +  +   
Sbjct: 1099 KIKRLEESNKKLALELEHEKGKLTGLGQSNAALREHNSILETALAKREADLVQLNLQVQA 1158

Query: 217  VVQ---EENQHMQMTIQALQDELRIQRD-LNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
            V+Q   EE++ M+  +QALQ  L  +++ +N L +Q ++++      A     +F+    
Sbjct: 1159 VLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVE----AGHNRRHFKAASL 1214

Query: 273  EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKAT-----E 327
            E     KEL    +  E +  +++ +   L  R+    + +   Q++   A+A      +
Sbjct: 1215 ELSEVKKEL----QAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQK 1270

Query: 328  EDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEM--------------HRRFENAPD 373
            +  E+  +       + +L+  ++QKE+E   L++++               +  +N   
Sbjct: 1271 QLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKS 1330

Query: 374  SAKTKALQTVIEMKD-----SKISSMERGLRDLEEEIQMLKSN---GALSTEERE----- 420
              +       +  KD     +K+S ++  ++ L ++ Q LK +   GA  T +       
Sbjct: 1331 ELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQLKLDLRRGAAKTRKEPKGEAS 1390

Query: 421  --------------------EEMKQME--VYRSHSKFMKNKVEQLKEELSSKEAQWEE 456
                                EE+ +    V +   K + + ++QLK+E+ S + Q EE
Sbjct: 1391 SSNPATPIKIPDCPVPASLLEELLRPPPAVSKEPLKNLNSCLQQLKQEMDSLQRQMEE 1448



 Score = 30.8 bits (68), Expect = 7.5
 Identities = 53/253 (20%), Positives = 92/253 (36%), Gaps = 28/253 (11%)

Query: 819  DNLNDSS-QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
            DNL  S     + S+RK+  +   L   ++E+   + +  + L +EE  R  A K +EE 
Sbjct: 102  DNLRKSQGTSAEGSVRKEALQSLRLSLPMQETQLCSTDSPLPLEKEEQVRLQARKWLEEQ 161

Query: 878  LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISE 937
            L      +Q+  S +    +   S  + E     L  E       +   K+ + L     
Sbjct: 162  LKQYRVKRQQERSSQPATKTRLFSTLDPE---LMLNPENLPRASTLAMTKEYSFLRTSVP 218

Query: 938  KDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHS 997
            +   +  L L            A  REK       K    ++++ +AD   +D   S+  
Sbjct: 219  RGPKVGSLGL-----------PAHPREK-------KTSKSSKIRSLADYRTED---SNAG 257

Query: 998  NQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQ 1057
            N   + P+PD        L QNRS     +  ++      D L    L   +   +D + 
Sbjct: 258  NSGGNVPAPDSTKG---SLKQNRSSAASVVSEISLSPDTDDRLENTSLAGDSVSEVDGND 314

Query: 1058 AAWENELQKMTRG 1070
            +   +     TRG
Sbjct: 315  SDSSSYSSASTRG 327


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  151 bits (382), Expect = 3e-36
 Identities = 218/1004 (21%), Positives = 419/1004 (41%), Gaps = 118/1004 (11%)

Query: 151  IMDLQTQLKEVLRENDL-------LRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKD 203
            + +++ Q K+V  E D        L + +E + S++   + S+   +  +L+      ++
Sbjct: 842  VAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNK-EQE 900

Query: 204  EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELT 263
            +  +I + KE   +   E Q  +  I+ L  +L  + D   +  ++  ++       E  
Sbjct: 901  QTKQILVEKENMILQMREGQKKE--IEILTQKLSAKEDSIHILNEEYETKFKNQ---EKK 955

Query: 264  EENFQRLHAEHERQAKELFL-----LRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ- 317
             E  ++   E +   K+  L     L+K LE   L +  +++  NA      K+LEM Q 
Sbjct: 956  MEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNA------KMLEMAQA 1009

Query: 318  -SKGLS-AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSA 375
             S G+S A +  E +++ +  +  E+H   L  ++   EK+ +   EE+    E      
Sbjct: 1010 NSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEK 1069

Query: 376  KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKF 435
            +    Q V E+K  KI        ++ +EI  LK  G        E  +Q++   +H   
Sbjct: 1070 E----QEVAELKQ-KILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS 1124

Query: 436  MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495
            +     +LK  L   E    +  K+   LQ ++ ++K        ++  L +KL+T   +
Sbjct: 1125 LAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEE 1184

Query: 496  FSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL--EEKETMLNKKTKQIQDMAEEKG 553
            F   K   E   +SL  K      L  E+ A++L +  ++ E +L  KT ++ +++  K 
Sbjct: 1185 FQSLKSSHEKSNKSLEDKSLEFKKLSEEL-AIQLDICCKKTEALLEAKTNELINISSSKT 1243

Query: 554  TQA--------GEIHDLKDMLDVKERKVNVLQKKIENLQE--------------QLRDKE 591
                            +K+ L +K   V+ L+ ++  L E              QL +KE
Sbjct: 1244 NAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKE 1303

Query: 592  KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR----------DER 641
             Q+ S+K  ++SL  +           ++A +EKE  I +LK++             + +
Sbjct: 1304 NQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELK 1363

Query: 642  EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK--------EHASSLASSGLKKD 693
            EK+ EI +  K L DL  ++      LSEKEA++  L+        E    +     K D
Sbjct: 1364 EKKVEISSLSKQLTDLNVQLQN-SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVD 1422

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK 753
            +  K    ALEQ  +   K     KKA     +           Q+  +E+    +  SK
Sbjct: 1423 TLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQH----------QNTVKELQIQLELKSK 1472

Query: 754  AQAEVDRLLEILKEVENEKNDK-DKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLE 812
               E D  + +LKE  +++N + D    E+E       KK +NL+ + + +  +  ++ +
Sbjct: 1473 EAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELED 1532

Query: 813  EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEK 872
               ++   +   ++ L++  ++KD   +EL + L+   ++  E++  + + E      E 
Sbjct: 1533 HITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLEN 1592

Query: 873  QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK----Q 928
            QV  +   +E  K+ELE +   + S ++ L   E  L +  A +   L+   E K    +
Sbjct: 1593 QVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIK 1652

Query: 929  EALLAAISEKDANIA------LLELSSSKKKTQEEVAALKREKDRLVQQLKQQT---QNR 979
            + LL+ + EK+          L EL++  ++ + EV  L+ EK + V+  + +T      
Sbjct: 1653 KQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILE-EKLKSVESSQSETLIVPRS 1711

Query: 980  MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQ-----NRSKLKLYIGHLTTLC 1034
             K +A   E +   S    Q  ++     + + L E ++      + K +    H    C
Sbjct: 1712 AKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRC 1771

Query: 1035 HDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEK 1078
              ++ LI           L+  +A  ++E Q M  G LQ+ELE+
Sbjct: 1772 QYQERLI----------KLEHAEAK-QHEDQSMI-GHLQEELEE 1803



 Score =  145 bits (366), Expect = 2e-34
 Identities = 210/1059 (19%), Positives = 451/1059 (42%), Gaps = 182/1059 (17%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK-IT 209
            + + + +L+++ +E +  R  +   ES L  S+   K   S +L       K++ +K IT
Sbjct: 548  LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKN-QSKDLAVHLEAEKNKHNKEIT 606

Query: 210  IWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
            +  E+++   E  +H Q  +    ++L++   L Q +Q +         + E  E+  + 
Sbjct: 607  VMVEKHKTELESLKHQQDALWT--EKLQV---LKQQYQTEMEK------LREKCEQEKET 655

Query: 270  LHAEHER--QAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327
            L  + E   QA    +  KTLE+++++ +T+ ++L++    + K    L+ + LS    +
Sbjct: 656  LLKDKEIIFQAHIEEMNEKTLEKLDVK-QTELESLSSELSEVLKARHKLEEE-LSVLKDQ 713

Query: 328  EDHERTRRLAEAEMHVHHLESLLEQ--KEKENSMLREEMHRRFENAPDSAKTKALQTVIE 385
             D  +    A+ +   +H +  ++   KE E S+ R E              KAL+  I 
Sbjct: 714  TDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTE--------------KALKDQIN 759

Query: 386  MKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSH-------SKFMKN 438
              +  +   ++ L++ +  ++ L+++   S  E ++   +++V++S+       +K  + 
Sbjct: 760  QLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEE 819

Query: 439  KVEQLKEELSSKEAQWEELKKKAAGLQA--------------EIGQVKQELSRKDTELLA 484
            ++ QL+++L   E +   L K+ A ++A              ++  + Q+L ++++E   
Sbjct: 820  QLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSE--- 876

Query: 485  LQTKLETLTNQFSD-----------------------------SKQHIEVLKESLTAKEQ 515
            ++ K+++LT  +                                K+ IE+L + L+AKE 
Sbjct: 877  MEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936

Query: 516  RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNV 575
               IL  E +      E+K   + +K K++Q+  ++K            +LD + +    
Sbjct: 937  SIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKK------------LLDQEAK---- 980

Query: 576  LQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLE-------EALAEKERT 628
            L+K++EN   +L  KEKQ ++  + ++  QA++     A++ LE       E+L E  R 
Sbjct: 981  LKKELENTALELSQKEKQFNA--KMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038

Query: 629  ---------IERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
                      ++L +Q +  +   + ++   ++++ +LK+K+ L   +  E    +  LK
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKE--ECLKMESQLKKAHEAALEARASPEMSDRI 737
            E        G+K+D+ L  L+  L+QK      L  +    KAH   LE   +  + +  
Sbjct: 1099 E-------EGVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN- 1150

Query: 738  QHLEREITRYKDESSKAQAEVDRLLEILKEVENE----KNDKDKKIAELERQVKDQNKKV 793
              L+ ++   K  + + + +V  L   LK  + E    K+  +K    LE +  +  K  
Sbjct: 1151 TFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLS 1210

Query: 794  ANLKHKEQVEKKKSAQMLEEARRREDNLNDS---------------SQQLQDSLRKKDDR 838
              L  +  +  KK+  +LE       N++ S               + +++++L  K   
Sbjct: 1211 EELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCT 1270

Query: 839  IEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSST 898
            + ELE  LR+  +      +   Q        E Q++ +   +E +  E E+++ +  + 
Sbjct: 1271 VSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQ 1330

Query: 899  QQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEV 958
            QQ+ +EKE+ +T L+ E  +++  V  MK+E     + EK   I+ L    +    Q + 
Sbjct: 1331 QQAASEKESCITQLKKELSENINAVTLMKEE-----LKEKKVEISSLSKQLTDLNVQLQN 1385

Query: 959  AALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQ 1018
            +    EK+  +  L++Q       + D  +D  FK    ++        + I  L ++D 
Sbjct: 1386 SISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSK--------EKISALEQVDD 1437

Query: 1019 NRSKL--------KLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMT-- 1068
              +K           +  H  T+   ++  I   L    +Y  D+     + EL +    
Sbjct: 1438 WSNKFSEWKKKAQSRFTQHQNTV---KELQIQLELKSKEAYEKDEQINLLKEELDQQNKR 1494

Query: 1069 ----RGQLQDELEKGERDNAELQ---EFANAILQQIADH 1100
                +G+++D+  K E+  + L+   +   A + ++ DH
Sbjct: 1495 FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDH 1533



 Score =  142 bits (358), Expect = 2e-33
 Identities = 196/876 (22%), Positives = 380/876 (43%), Gaps = 112/876 (12%)

Query: 319  KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTK 378
            K L  K +EE  +  + LA A+   +   S   +     S   E++     N  +S  T+
Sbjct: 3    KKLKQKISEEQQQLQQALAPAQASSN--SSTPTRMRSRTSSFTEQLDEGTPNR-ESGDTQ 59

Query: 379  ALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKF--- 435
            +    ++++   + S+ R    ++E +    S  +L      E + ++++  S + F   
Sbjct: 60   SFAQKLQLRVPSVESLFRS--PIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPP 117

Query: 436  ---------------------MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE 474
                                 +  ++ +++  LSS   ++ EL      LQ E  +++  
Sbjct: 118  SDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGI 177

Query: 475  LSRKDTELLALQTKLETLTNQFSDSKQHI-EVLKESLTAKEQRAAILQTEVDALRLRLEE 533
            LS+   + L    +L         +K+H+ E    SL  K+Q  ++LQT+V  L+ RL  
Sbjct: 178  LSQSQDKSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRN 237

Query: 534  KETMLN--KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE 591
                ++  K   Q++  AE       E +   D   V E   +V  K +E LQ++++ +E
Sbjct: 238  GPMNVDVLKPLPQLEPQAE---VFTKEENPESDGEPVVEDGTSV--KTLETLQQRVKRQE 292

Query: 592  KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 651
              +   KE ++S +   T   +    L+E L E+ + +E++K+    ++ +   ++ + K
Sbjct: 293  NLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAK 352

Query: 652  KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK---------KDSRLKTLEIA 702
              ++ L++   ++  +   +    L++KE   +   S +K         ++ + K+   A
Sbjct: 353  NLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAA 412

Query: 703  LE---------QKKEEC-----LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748
             E         QK EE       +M+ Q+K   + + E R S  +   +  +++E+    
Sbjct: 413  FEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERIS--LQQELSRVKQEVVDVM 470

Query: 749  DESSKAQ-AEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN------LKHKEQ 801
             +SS+ Q A++ +L E  KE+  ++ +  KK+   ER+ ++Q K          LK  ++
Sbjct: 471  KKSSEEQIAKLQKLHE--KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528

Query: 802  VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKD---DRIEELEEALRESVQITAEREM 858
             E+++S  + E   +++  L +S  +L+D  ++ +    RI ELE +L +S+Q    +  
Sbjct: 529  KEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 859  VLAQEESARTNAEKQVEELLMAMEKVKQELESMK--------AKLSSTQQSL-------- 902
             LA    A  N  K  +E+ + +EK K ELES+K         KL   +Q          
Sbjct: 589  DLAVHLEAEKN--KHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646

Query: 903  ----AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSKKKTQEE 957
                 EKET L +     + H+EE+ E   E L    +E ++ +  L E+  ++ K +EE
Sbjct: 647  EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706

Query: 958  VAALKREKDRLVQQLK---QQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL 1014
            ++ LK + D++ Q+L+    + +N  +   D+   +H     S Q   K   DQI Q  L
Sbjct: 707  LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEH---EVSIQRTEKALKDQINQLEL 763

Query: 1015 ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR----- 1069
             L +    LK +  H+  L  + D     G    AS  LD  Q ++++   + T+     
Sbjct: 764  LLKERDKHLKEHQAHVENL--EADIKRSEGELQQASAKLDVFQ-SYQSATHEQTKAYEEQ 820

Query: 1070 -GQLQDELEKGERDNAELQEFANAILQQIADHCPDI 1104
              QLQ +L   E +   L +    +  Q  D C ++
Sbjct: 821  LAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856



 Score =  139 bits (351), Expect = 1e-32
 Identities = 180/855 (21%), Positives = 372/855 (43%), Gaps = 99/855 (11%)

Query: 193  ELKKERAL---RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQR-DLNQLFQQ 248
            ELK++  L    K+E +K   W      ++EE      T+  LQ++L+ +   +N L Q 
Sbjct: 1075 ELKQKILLFGCEKEEMNKEITW------LKEEGVKQDTTLNELQEQLKQKSAHVNSLAQD 1128

Query: 249  DSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES 308
            ++  +            + ++L  +  +  KE   L++ L E+++  E  K+ ++     
Sbjct: 1129 ETKLKA-----------HLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177

Query: 309  IKKLLEMLQS---------KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE--- 356
            +K   E  QS         K L  K+ E          + ++     E+LLE K  E   
Sbjct: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELIN 1237

Query: 357  ------NSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
                  N++L    H +        +T  ++  + +K   +S +E  LR L EE   L  
Sbjct: 1238 ISSSKTNAILSRISHCQH-------RTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNI 1290

Query: 411  NGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEE-------LSSKEAQWEELKKKAAG 463
            +   +T + EE+  Q++  ++  + +  + E L++E        S KE+   +LKK+ + 
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350

Query: 464  LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
                +  +K+EL  K  E+ +L  +L  L  Q          L+ S++  E+ AAI    
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQ----------LQNSISLSEKEAAI---- 1396

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
              +LR + +E++  L     Q+QD++ +  T + E     + +D    K +  +KK ++ 
Sbjct: 1397 -SSLRKQYDEEKCEL---LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSR 1452

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK 643
              Q ++  K++  ++  +KS +A     D  +  L+E L ++ +  + LK + + D+ + 
Sbjct: 1453 FTQHQNTVKELQ-IQLELKSKEA--YEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKM 1509

Query: 644  QEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIAL 703
            +++  N + +LK    ++  L+  +++K   +  L E    L +   +KD   K L   L
Sbjct: 1510 EKKESNLETELKSQTARIMELEDHITQKTIEIESLNE---VLKNYNQQKDIEHKELVQKL 1566

Query: 704  EQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE 763
            +  +E   + ++++K+A E  L       + +++  ++ E+   K E       V    E
Sbjct: 1567 QHFQELGEEKDNRVKEAEEKILT------LENQVYSMKAELETKKKELEHVNLSVKSKEE 1620

Query: 764  ILKEVENE-KNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLN 822
             LK +E+  +++   K+AEL+R+ +   +K+A +K      K+  +QM E+  + +    
Sbjct: 1621 ELKALEDRLESESAAKLAELKRKAE---QKIAAIK------KQLLSQMEEKEEQYKKGTE 1671

Query: 823  DSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAME 882
                +L   L++++  +  LEE L+      +E  +V    ++     E++  +    ++
Sbjct: 1672 SHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731

Query: 883  KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
            K  +E      K+S  Q++L EKE  L  +  E+ + +    EM+ +     I  + A  
Sbjct: 1732 KTYEE------KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785

Query: 943  ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
               E  S     QEE+    ++   +V Q  ++   +  + A    ++ F          
Sbjct: 1786 KQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEK 1845

Query: 1003 KPSPDQIIQPLLELD 1017
            + +   + Q + ELD
Sbjct: 1846 ELTCQILEQKIKELD 1860



 Score =  137 bits (344), Expect = 7e-32
 Identities = 187/912 (20%), Positives = 406/912 (44%), Gaps = 134/912 (14%)

Query: 150  TIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPE---LKKERALRKDEAS 206
            T+ +L+ QL+++  E + L    +    +L    N IK+  +     + ++ AL+K+  +
Sbjct: 1270 TVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGN 1329

Query: 207  KITIWKEQYRVVQEENQHMQMTIQA---LQDELRIQR-DLNQLFQQDSSSRTGEPCVAEL 262
            +     E+   + +  + +   I A   +++EL+ ++ +++ L +Q             L
Sbjct: 1330 QQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQ-------------L 1376

Query: 263  TEENFQRLHAEHERQAKELFL--LRKTLEEMELRIETQKQTLNARDESI--KKLLEMLQS 318
            T+ N Q L        KE  +  LRK  +E +  +  Q Q L+ + +++  +K+  + Q 
Sbjct: 1377 TDLNVQ-LQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV 1435

Query: 319  KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN-------SMLREEM---HRRF 368
               S K +E   +   R  + +  V  L+  LE K KE        ++L+EE+   ++RF
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF 1495

Query: 369  -----ENAPDSAKTKA----LQTVIEMKDSKISSMERGLRDLEEEIQ----MLKSNGALS 415
                 E   D +K +     L+T ++ + ++I  +E  +     EI+    +LK+     
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555

Query: 416  TEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQEL 475
              E +E +++++ ++   +   N+V++ +E++ + E Q   +K +    + E+  V   +
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSV 1615

Query: 476  SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
              K+ EL AL+ +LE      S+S   +  LK      EQ+ A ++ +   L  ++EEKE
Sbjct: 1616 KSKEEELKALEDRLE------SESAAKLAELKRKA---EQKIAAIKKQ---LLSQMEEKE 1663

Query: 536  TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK---IENLQEQLRDKEK 592
                K T+               + +L   L  +ER+V++L++K   +E+ Q +     +
Sbjct: 1664 EQYKKGTES-------------HLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPR 1710

Query: 593  QMSSLKERVKSLQADTTNT-----DTALTTLEEALAEKERTIERLKEQRDRD-------- 639
               ++    +  +AD+        +  ++ L+  L EKE+ ++R+ ++++          
Sbjct: 1711 SAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR 1770

Query: 640  ----------------EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LDLKEH 681
                            + E Q  I + +++L++  +K SL+     EKE     +  K++
Sbjct: 1771 CQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQN 1830

Query: 682  ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE 741
              ++     K     +     LEQK +E      + K+ H   +E   S    +++Q L+
Sbjct: 1831 LENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKY--EKLQALQ 1888

Query: 742  REITRYKD----ESSKAQAEVDRLLE--ILKEVENEKNDKDKKIAELERQVKDQNKKVAN 795
            +   R K     E +  +     L++  +L  +E + ND + K+A  ER+ +   K++  
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948

Query: 796  LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 855
            L+   ++ +K+  Q LE  ++  D      Q+ ++ ++++ + +E    +  +  Q+  E
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYD------QEREEKIKQEQEDLELKHNSTLK--QLMRE 2000

Query: 856  REMVLAQEESARTNAEKQVEELLMAMEKVKQE-LESMKAKLSSTQQSLAEKETHLTNLRA 914
                LAQ+E      E  ++E +   ++V+ E LES + + +   + +AEK+  L     
Sbjct: 2001 FNTQLAQKEQ---ELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDL----K 2053

Query: 915  ERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 974
               K  EE+L+ ++E + A + +    +  L+    +K  QEE        +  + +L+ 
Sbjct: 2054 RTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG---NDNVTIMELQT 2110

Query: 975  QTQNRMKLMADN 986
            Q   +  L++D+
Sbjct: 2111 QLAQKTTLISDS 2122



 Score =  108 bits (270), Expect = 3e-23
 Identities = 156/736 (21%), Positives = 329/736 (44%), Gaps = 91/736 (12%)

Query: 149  NTIMDLQTQLKEVLRENDLLRKDVEVKESKLS-SSMNSIKTFWSPELKKERA-LRKDEAS 206
            NT+ +LQ QL+  L+  +   KD ++   K      N        E++ +++ + K E++
Sbjct: 1458 NTVKELQIQLE--LKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESN 1515

Query: 207  KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTE-- 264
              T  K Q   + E   H+      ++    + ++ NQ  Q+D   +       EL +  
Sbjct: 1516 LETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQ--QKDIEHK-------ELVQKL 1566

Query: 265  ENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAK 324
            ++FQ L  E + + KE        EE  L +E Q  ++ A  E+ KK LE +    LS K
Sbjct: 1567 QHFQELGEEKDNRVKEA-------EEKILTLENQVYSMKAELETKKKELEHVN---LSVK 1616

Query: 325  ATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVI 384
            + EE+ +      E+E     L  L  + E++ + +++++  + E   +  K K  ++ +
Sbjct: 1617 SKEEELKALEDRLESESAAK-LAELKRKAEQKIAAIKKQLLSQMEEKEEQYK-KGTESHL 1674

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKS-------------NGALSTEERE----------- 420
               ++K+   ER +  LEE+++ ++S             N A  TE+ E           
Sbjct: 1675 SELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTY 1734

Query: 421  -EEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
             E++  ++   +  + +  +V Q KEE  S   +    + +   ++ E  + KQ    +D
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMR-CQYQERLIKLEHAEAKQH---ED 1790

Query: 480  TELLA-LQTKLETLTNQFS-DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET- 536
              ++  LQ +LE    ++S    QH+E  KE      Q    L+   D ++  L+EKE  
Sbjct: 1791 QSMIGHLQEELEEKNKKYSLIVAQHVE--KEGGKNNIQAKQNLENVFDDVQKTLQEKELT 1848

Query: 537  --MLNKKTKQIQD-MAEEKGTQAGEIHDLKDMLDVKERKVNVLQ------KKIENLQEQL 587
              +L +K K++   +  +K     E+ +L      K  K+  LQ      K  E L+E  
Sbjct: 1849 CQILEQKIKELDSCLVRQKEVHRVEMEELTS----KYEKLQALQQMDGRNKPTELLEENT 1904

Query: 588  RDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEI 647
             +K K      + + +++A   + +  L   E    +  + I RL++      +E Q+E+
Sbjct: 1905 EEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQEL 1964

Query: 648  DNYKKDL-KDLKEKVSLLQGDLSEKEASLLD--LKEHASSLASSGLKKDSRLKTLEIALE 704
            +  KK+  ++ +EK+   Q DL  K  S L   ++E  + LA        + + LE+ ++
Sbjct: 1965 EILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ-------KEQELEMTIK 2017

Query: 705  QKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEI 764
            +   +  ++E++L ++H+     +   +++++   L+R   RY++      A  + +   
Sbjct: 2018 ETINKAQEVEAELLESHQEETN-QLLKKIAEKDDDLKRTAKRYEEI---LDAREEEMTAK 2073

Query: 765  LKEVENEKNDKDKKIAE-LERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLND 823
            +++++ +  +  KK  + LE++    N  V  ++ + Q+ +K +  ++ +++ +E    +
Sbjct: 2074 VRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTT--LISDSKLKEQEFRE 2131

Query: 824  SSQQLQDSLRKKDDRI 839
                L+D L+K +  +
Sbjct: 2132 QIHNLEDRLKKYEKNV 2147



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 122/630 (19%), Positives = 261/630 (41%), Gaps = 129/630 (20%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
            L + +DN + + + ++  +  +   ++ ++E K+ +L     S+K+        E  L  
Sbjct: 1572 LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLES 1631

Query: 203  DEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAEL 262
            + A+K+           E  +  +  I A++ +L     L+Q+ +++   + G       
Sbjct: 1632 ESAAKLA----------ELKRKAEQKIAAIKKQL-----LSQMEEKEEQYKKG------- 1669

Query: 263  TEENFQRLHAEHERQAKELFLLRKTLEEMELR---------------------------- 294
            TE +   L+ + + + +E+ +L + L+ +E                              
Sbjct: 1670 TESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729

Query: 295  -IETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDH--------ERTRRL--AEAEMH- 342
              +T ++ ++    ++ +  ++LQ  G   + T   H        ER  +L  AEA+ H 
Sbjct: 1730 VQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE 1789

Query: 343  ----VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA--------LQTVIEMKDSK 390
                + HL+  LE+K K+ S++  + H   E   ++ + K         +Q  ++ K+  
Sbjct: 1790 DQSMIGHLQEELEEKNKKYSLIVAQ-HVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELT 1848

Query: 391  ISSMERGLRDL------EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
               +E+ +++L      ++E+  ++     S  E+ + ++QM+     ++ ++   E+  
Sbjct: 1849 CQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKS 1908

Query: 445  EE-------LSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFS 497
            +        LS+ EAQ  +L+ K AG + E    KQ+L +   E++ LQ  L  L     
Sbjct: 1909 KSHLVQPKLLSNMEAQHNDLEFKLAGAERE----KQKLGK---EIVRLQKDLRMLR---K 1958

Query: 498  DSKQHIEVLKESLTAKEQRAAILQTEVD-------ALRLRLEEKETMLNKKTKQIQDMAE 550
            + +Q +E+LK+    +E+   I Q + D        L+  + E  T L +K ++++   +
Sbjct: 1959 EHQQELEILKKEYD-QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIK 2017

Query: 551  EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 610
            E   +A E+    ++L+  + + N L KKI    + L+   K+   +             
Sbjct: 2018 ETINKAQEVE--AELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEI------------- 2062

Query: 611  TDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSE 670
                L   EE +  K R ++   E+  +  ++K E+ +N   D   + E    LQ  L++
Sbjct: 2063 ----LDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIME----LQTQLAQ 2114

Query: 671  KEASLLDLKEHASSLASSGLKKDSRLKTLE 700
            K   + D K             + RLK  E
Sbjct: 2115 KTTLISDSKLKEQEFREQIHNLEDRLKKYE 2144



 Score = 67.4 bits (163), Expect = 7e-11
 Identities = 98/490 (20%), Positives = 210/490 (42%), Gaps = 69/490 (14%)

Query: 144  RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLS-------SSMNSIKTFWSPELKK 196
            ++  ++ + +L T+L+E  RE  +L + ++  ES  S       S+ N        E   
Sbjct: 1667 KKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS 1726

Query: 197  ERALRKDEASKITIWK----EQYRVVQEENQHMQMTIQA-LQDELRIQRDLNQLFQQDSS 251
            +  ++K    KI++ +    E+ +++Q   Q  + T+ +  +   + Q  L +L   ++ 
Sbjct: 1727 QGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786

Query: 252  SRTGEPCVAELTEE------NFQRLHAEHER--------QAKELFL-----LRKTLEEME 292
                +  +  L EE       +  + A+H          QAK+        ++KTL+E E
Sbjct: 1787 QHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKE 1846

Query: 293  LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
            L  +  +Q +   D  + +  E+ + +     +  E  +  +++         LE   E+
Sbjct: 1847 LTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEE 1906

Query: 353  KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKD--SKISSMERGLRDL----EEEIQ 406
            K K + +++ ++    E   +  + K      E +    +I  +++ LR L    ++E++
Sbjct: 1907 KSKSH-LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELE 1965

Query: 407  MLKSNGALSTEEREEEMKQME--VYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
            +LK       +EREE++KQ +  +   H+  +K  + +   +L+ KE + E   K+    
Sbjct: 1966 ILKKE---YDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINK 2022

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAI----L 520
              E+     E  +++T  L     L+ +  +  D K+  +  +E L A+E+        L
Sbjct: 2023 AQEVEAELLESHQEETNQL-----LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077

Query: 521  QTEVDALRLRLEEK-----------------ETMLNKKTKQIQDMAEEKGTQAGEIHDLK 563
            QT+++ L+ + ++K                 +T L +KT  I D   ++     +IH+L+
Sbjct: 2078 QTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLE 2137

Query: 564  DMLDVKERKV 573
            D L   E+ V
Sbjct: 2138 DRLKKYEKNV 2147


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score =  151 bits (381), Expect = 4e-36
 Identities = 182/855 (21%), Positives = 370/855 (43%), Gaps = 86/855 (10%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKTFWSPELKKERALRKDEASKI 208
            IM+L+  L   ++E   LR+ +E  +    +  S++ ++   S + K E   R D   +I
Sbjct: 501  IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-VTRTDHQREI 559

Query: 209  TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQ 268
            T  KE +   +E +Q     +    ++L  + +  +   + ++    +  V  L +   +
Sbjct: 560  TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSD--VIALWKSKLE 617

Query: 269  RLHAEHERQAKELF------LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLS 322
               A H++  +EL       L  +T E  EL+ + +K  L+ + E     +E LQ+    
Sbjct: 618  TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE-----IENLQN---- 668

Query: 323  AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQT 382
                ++D ER     E E     L  ++  KEKENS+  E +  + + A D       Q 
Sbjct: 669  ----QQDSERAAHAKEMEALRAKLMKVI--KEKENSL--EAIRSKLDKAED-------QH 713

Query: 383  VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEER--------EEEMKQMEVYRSHSK 434
            ++EM+D+     E  ++  E E+   K N      +         EE++  ++  R  S 
Sbjct: 714  LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 773

Query: 435  FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
              K+++++L+++L + E Q + L+ +     ++   + +EL  ++ +L  LQ  L  ++ 
Sbjct: 774  EGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQ 833

Query: 495  QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
                 ++ +++LKE      + A  +Q  +     +L +KE   N  +  ++ + E    
Sbjct: 834  VKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 893

Query: 555  QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTA 614
               +  +  +  +   +    L+  I  + +   D   Q++ + + ++  + D       
Sbjct: 894  MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK 953

Query: 615  LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 674
            LT   E  +  +++IE   +   + E+ +QE    ++++ K+L+ K+S L+  +      
Sbjct: 954  LTKANENASFLQKSIE---DMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQ 1010

Query: 675  LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMS 734
              +LK       S     +++ K  EI L+  ++  L  E +LK A E         E S
Sbjct: 1011 CQELKARYERATS-----ETKTKHEEI-LQNLQKTLLDTEDKLKGARE---------ENS 1055

Query: 735  DRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKND-----KDKKIAELERQVKDQ 789
              +Q LE E+ +  D++  AQ   D  ++I++++  EK +     +D K    + Q +  
Sbjct: 1056 GLLQELE-ELRKQADKAKAAQTAED-AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELD 1113

Query: 790  NKKVANLKHKEQVEKKKSA-----QMLEEARRREDNLNDSSQQLQDSLRK-KDDRIEELE 843
              K  NLK+ E++ K K       Q +EE R+  + L  ++ Q    L   +++ ++  E
Sbjct: 1114 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAE 1173

Query: 844  EALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA 903
            E  R   ++T+ +++     E  R+    Q+ E+     K  ++ +  KA L   Q+S++
Sbjct: 1174 ELGRSRDEVTSHQKL-----EEERSVLNNQLLEMKKRESKFIKDADEEKASL---QKSIS 1225

Query: 904  EKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKR 963
                 LT   AE  K   EV  ++ E      S K  +  +  L S K K + +V  L+ 
Sbjct: 1226 ITSALLTEKDAELEKLRNEVTVLRGE----NASAKSLHSVVQTLESDKVKLELKVKNLEL 1281

Query: 964  EKDRLVQQLKQQTQN 978
            +     +QL   + N
Sbjct: 1282 QLKENKRQLSSSSGN 1296



 Score =  132 bits (333), Expect = 1e-30
 Identities = 202/875 (23%), Positives = 384/875 (43%), Gaps = 136/875 (15%)

Query: 181  SSMNSIKTFWSPELKKERALRKDE---ASKITIWKEQYRVVQEENQHMQMTIQALQDELR 237
            SSM+S+ +  S    +   L +     A KI+        ++E+ QH++        +L 
Sbjct: 317  SSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIE--------QLL 368

Query: 238  IQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIET 297
             +RDL +     ++S  GE       E+        H++   EL      L  M    + 
Sbjct: 369  AERDLERAEVAKATSHVGE------IEQELALARDGHDQHVLELEAKMDQLRTMVEAADR 422

Query: 298  QKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKEN 357
            +K  L  + E  K+ +E LQ +      T+ D E   +L  A +           KE E 
Sbjct: 423  EKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARI-----------KELEQ 471

Query: 358  SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
            S+L E             KTKA +   E++D++++++    R +E     L+ + AL  +
Sbjct: 472  SLLFE-------------KTKADKLQRELEDTRVATVSEKSRIME-----LEKDLALRVQ 513

Query: 418  EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQEL-S 476
            E  E  +++E  +       +    L +E+SS +   E+L+      Q EI  +K+   +
Sbjct: 514  EVAELRRRLESNKPAGDV--DMSLSLLQEISSLQ---EKLEVTRTDHQREITSLKEHFGA 568

Query: 477  RKDT---ELLALQTKLETLTNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLRLE 532
            R++T   E+ AL T  E L+ +    K  +E   KE+        + L+T + + +  +E
Sbjct: 569  REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAME 628

Query: 533  EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKE- 591
            E +   +K            GT+  E  +LK  +   E+     Q +IENLQ Q +D E 
Sbjct: 629  ELKVSFSKGL----------GTETAEFAELKTQI---EKMRLDYQHEIENLQNQ-QDSER 674

Query: 592  ------------KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
                        K M  +KE+  SL+A  +  D A    ++ L E E T+ +L+E   + 
Sbjct: 675  AAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKA---EDQHLVEMEDTLNKLQEAEIKV 731

Query: 640  E---------REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGL 690
            +          E+ + IDN+   LK  +EK  LL  D   K +S  + K     L     
Sbjct: 732  KELEVLQAKCNEQTKVIDNFTSQLKATEEK--LLDLDALRKASS--EGKSEMKKLRQQLE 787

Query: 691  KKDSRLKTLEIA--LEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYK 748
              + ++K LEI    E  K   +  E Q ++     L+   S E+S   + LE+E+   K
Sbjct: 788  AAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS-EVSQVKETLEKELQILK 846

Query: 749  DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 808
            ++ ++A  E   +   ++E  N+ + K+++   L   ++   + +A+++ K + + ++  
Sbjct: 847  EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 906

Query: 809  QMLEEARRREDNL-------NDSSQQL---QDSLRKKDDRIEELEEALRES------VQI 852
            Q+++   + E+++        D+S QL    D LR K+  +EEL+  L ++      +Q 
Sbjct: 907  QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQK 966

Query: 853  TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL 912
            + E +M +  E+S +  A+K  EE     ++++++L  ++ K+ ++     E +      
Sbjct: 967  SIE-DMTVKAEQSQQEAAKKHEEE----KKELERKLSDLEKKMETSHNQCQELKARYERA 1021

Query: 913  RAERRKHLEEVLEMKQEALLAAISE----KDANIALLELSSSKKKTQEEVAALKREKDRL 968
             +E +   EE+L+  Q+ LL    +    ++ N  LL+     +K  ++  A +  +D +
Sbjct: 1022 TSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAM 1081

Query: 969  VQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK 1003
             Q ++Q T+ + + +A + ED       + QTN K
Sbjct: 1082 -QIMEQMTKEKTETLA-SLED-------TKQTNAK 1107



 Score =  118 bits (296), Expect = 3e-26
 Identities = 161/794 (20%), Positives = 343/794 (43%), Gaps = 131/794 (16%)

Query: 115  SSGVASDTIAFGEHHLPPVSMASTVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEV 174
            S G+ ++T  F E       M     H +   ++    +     KE+      L K ++ 
Sbjct: 635  SKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKE 694

Query: 175  KESKLSSSMNSIKTFWSPEL-KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ 233
            KE+ L +  + +       L + E  L K + ++I +  ++  V+Q +       I    
Sbjct: 695  KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV--KELEVLQAKCNEQTKVIDNFT 752

Query: 234  DELRIQR----DLNQLFQQDSSSRTGEPCV---AELTEENFQRLHAEHERQAKELFLLRK 286
             +L+       DL+ L +  S  ++    +    E  E+  + L  E   ++ +   + +
Sbjct: 753  SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 812

Query: 287  TLEEMELRIETQKQTLNARD---ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHV 343
             L+  EL++   ++ L+      E+++K L++L+ K   A+A+EE     R + E    +
Sbjct: 813  ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK--FAEASEEAVSVQRSMQETVNKL 870

Query: 344  HHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEE 403
            H       QKE++ +ML  ++ +  EN  D      ++     KD +   + +    LE 
Sbjct: 871  H-------QKEEQFNMLSSDLEKLRENLAD------MEAKFREKDEREEQLIKAKEKLEN 917

Query: 404  EI------------QMLKSNGALSTEEREEEMKQMEVYRS--HSKFMKNKVEQL--KEEL 447
            +I            Q+ K N  L  +ER+ E  Q+++ ++  ++ F++  +E +  K E 
Sbjct: 918  DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ 977

Query: 448  SSKEA--QWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI-E 504
            S +EA  + EE KK+   L+ ++  +++++     +   L+ + E  T++     + I +
Sbjct: 978  SQQEAAKKHEEEKKE---LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 1034

Query: 505  VLKESLT--------AKEQRAAILQTEVDALRLRLEE-------------KETMLNKKTK 543
             L+++L         A+E+ + +LQ E++ LR + ++              E M  +KT+
Sbjct: 1035 NLQKTLLDTEDKLKGAREENSGLLQ-ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1093

Query: 544  QIQDMAEEKGTQA-----------------GEIHDLKDMLDVKERKVNVLQKKIENLQEQ 586
             +  + + K T A                  E++  K++L V+ +K+   +K+IE L++ 
Sbjct: 1094 TLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQA 1153

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 646
               K +Q+S+L+E    L  +   +   +T+ ++   E+ER++  L  Q    ++ + + 
Sbjct: 1154 AAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK--LEEERSV--LNNQLLEMKKRESKF 1209

Query: 647  IDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 706
            I +  ++   L++ +S+    L+EK+A L  L+   + L      +++  K+L   ++  
Sbjct: 1210 IKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG----ENASAKSLHSVVQTL 1265

Query: 707  KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 766
            + + +K+E ++K                    +LE ++   K + S +    D       
Sbjct: 1266 ESDKVKLELKVK--------------------NLELQLKENKRQLSSSSGNTD------- 1298

Query: 767  EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA-RRREDNLNDSS 825
                 + D+D++    E Q+   N  + +L+ K Q  K K   M E A     D+LN+  
Sbjct: 1299 ----TQADEDERAQ--ESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1352

Query: 826  QQLQDSLRKKDDRI 839
               Q+   KK  R+
Sbjct: 1353 SDDQEKQSKKKPRL 1366



 Score =  100 bits (248), Expect = 1e-20
 Identities = 176/821 (21%), Positives = 346/821 (42%), Gaps = 129/821 (15%)

Query: 372  PDSAKTKALQTVI-----EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
            P  AK  A++ V+      +K S  +S    +  +   +    S   L TE      +++
Sbjct: 288  PAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKI 347

Query: 427  EVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK----DTEL 482
                +  + +K K + +++ L+ ++ +  E+ K  +     +G+++QEL+      D  +
Sbjct: 348  SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATS----HVGEIEQELALARDGHDQHV 403

Query: 483  LALQTKLETLT--------------NQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR 528
            L L+ K++ L               NQ  + K+ +E L+  +  +      L+T+     
Sbjct: 404  LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEH 463

Query: 529  LRLEEKE-TMLNKKTK------QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581
             R++E E ++L +KTK      +++D      ++   I +L+  L ++ ++V  L++++E
Sbjct: 464  ARIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLE 523

Query: 582  NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641
            +  +   D +  +S L+E + SLQ            LE    + +R I  LKE     E 
Sbjct: 524  S-NKPAGDVDMSLSLLQE-ISSLQEK----------LEVTRTDHQREITSLKEHFGAREE 571

Query: 642  EKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK-DSRLKTLE 700
              Q+EI    K L    EK       LS++  SL    EHA+   S  +    S+L+T  
Sbjct: 572  THQKEI----KALYTATEK-------LSKENESLKSKLEHANKENSDVIALWKSKLETA- 619

Query: 701  IALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA---- 756
            IA  Q+  E LK+        E A  A    ++       + EI   +++    +A    
Sbjct: 620  IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 679

Query: 757  EVD----RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLE 812
            E++    +L++++KE EN       K+ + E Q   + +   N K +E   K K  ++L+
Sbjct: 680  EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN-KLQEAEIKVKELEVLQ 738

Query: 813  EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEK 872
                 +  + D+       L+  ++++ +L+   + S +  +E + +  Q E+A    EK
Sbjct: 739  AKCNEQTKVIDN---FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAA----EK 791

Query: 873  QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRK--HLEEVLEMKQEA 930
            Q++ L     ++++  ES KA  SS  + L  +E  LTNL+    +   ++E LE + + 
Sbjct: 792  QIKHL-----EIEKNAESSKA--SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 844

Query: 931  LLAAISEKDANIALLE-------------------LSSSKKKTQEEVAALK---REKDRL 968
            L    +E       ++                   LSS  +K +E +A ++   REKD  
Sbjct: 845  LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 904

Query: 969  VQQL---KQQTQNR----MKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRS 1021
             +QL   K++ +N     MK+  DN         +      +   +++   L + ++N S
Sbjct: 905  EEQLIKAKEKLENDIAEIMKMSGDN--SSQLTKMNDELRLKERDVEELQLKLTKANENAS 962

Query: 1022 KLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKM------TRGQLQDE 1075
             L+  I  +T                 A+   ++++   E +L  +      +  Q Q+ 
Sbjct: 963  FLQKSIEDMTVKAEQSQ--------QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 1014

Query: 1076 LEKGERDNAELQEFANAILQQIADHCPDILEQVVNALEESS 1116
              + ER  +E +     ILQ +     D  +++  A EE+S
Sbjct: 1015 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1055


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  150 bits (379), Expect = 6e-36
 Identities = 201/925 (21%), Positives = 411/925 (44%), Gaps = 122/925 (13%)

Query: 148  DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
            +  + +++ + +++L E ++L + ++  E++L +    ++   + + ++   +  D  S+
Sbjct: 872  EGELEEMERKHQQLLEEKNILAEQLQA-ETELFAEAEEMRARLAAKKQELEEILHDLESR 930

Query: 208  ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
            +   +E+ +++Q E + MQ  IQ L+++L  +    Q  Q +    T E  + ++ EE  
Sbjct: 931  VEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKV--TAEAKIKKM-EEEI 987

Query: 268  QRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL-------NARDESIKKLLEMLQSKG 320
              L  ++ +  KE  L+   + E   ++  +++         N ++  I  L E L+ + 
Sbjct: 988  LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047

Query: 321  LSAKATEE-----DHERTR---RLAEAEMHVHHLESLLEQKEKE--NSMLR---EEMHRR 367
             + +  E+     D E T    ++AE +  +  L+  L +KE+E   ++ R   E +H+ 
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107

Query: 368  FENAPD-----SAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEE 422
              NA        A+   LQ   E + +  +  E+  RDL EE++ LK+      +  +  
Sbjct: 1108 --NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTE---LEDTLDTT 1162

Query: 423  MKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTEL 482
              Q E+     + +    + L+EE  + EAQ ++++++ A    E+ +  ++  R    L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222

Query: 483  LALQTKLETLTNQFS-------DSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE 535
               +  LET   + +         K   E  ++ L A+ Q      +E D LR+ L EK 
Sbjct: 1223 EKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282

Query: 536  TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595
            + L  +   +  + EE      E   +K   D        L+ ++++ QE L+++ +Q  
Sbjct: 1283 SKLQNELDNVSTLLEE-----AEKKGIKFAKDAAS-----LESQLQDTQELLQEETRQKL 1332

Query: 596  SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
            +L  R++ L+ +  +        EEA    E+ +  L+ Q   D ++K ++     + L+
Sbjct: 1333 NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL-ADTKKKVDDDLGTIESLE 1391

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK-----DSRLKTLEIALEQKKEEC 710
            + K+K+         K+A  L  +    +LA   L+K        L  L + L+ +++  
Sbjct: 1392 EAKKKLL--------KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVA 1443

Query: 711  LKMESQLKK-----AHEAALEARASPEMSDRIQHLERE-------ITRYKDESSKAQAEV 758
              +E + KK     A E ++ AR + E  DR +   RE       + R  +E+ +A+ E 
Sbjct: 1444 SNLEKKQKKFDQLLAEEKSISARYAEER-DRAEAEAREKETKALSLARALEEALEAKEEF 1502

Query: 759  DR----LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
            +R    L   ++++ + K+D  K + ELE+  +   ++V  ++ + + E +   Q  E+A
Sbjct: 1503 ERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE-ELEDELQATEDA 1561

Query: 815  RRR-EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ----------------ITAERE 857
            + R E N+     Q +  L+ +D++ EE +  L + V+                + ++++
Sbjct: 1562 KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK 1621

Query: 858  MVL------AQEESA---RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETH 908
            M +      AQ E+A   R    KQ+ +L   M+  ++ELE  +A          E E  
Sbjct: 1622 MEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKK 1681

Query: 909  LTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRL 968
            L +L AE  + L+E L   + A   A  E+D      EL+     +    +AL  EK RL
Sbjct: 1682 LKSLEAEILQ-LQEELASSERARRHAEQERD------ELADEITNSASGKSALLDEKRRL 1734

Query: 969  VQQLKQ------QTQNRMKLMADNY 987
              ++ Q      + Q+ M+L+ D +
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRF 1759



 Score =  146 bits (369), Expect = 9e-35
 Identities = 173/809 (21%), Positives = 358/809 (44%), Gaps = 111/809 (13%)

Query: 293  LRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
            L++  Q++ L A+DE + K+ E    K    +   E+ ER  +    E ++     L EQ
Sbjct: 845  LQVTRQEEELQAKDEELLKVKE----KQTKVEGELEEMERKHQQLLEEKNI-----LAEQ 895

Query: 353  KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
             + E  +  E    R   A   AK + L+ ++   +S++   E   + L+ E + ++++ 
Sbjct: 896  LQAETELFAEAEEMRARLA---AKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHI 952

Query: 413  ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
                E+ +EE    +  +      + K+++++EE+   E Q  +  K+   ++  I +  
Sbjct: 953  QDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012

Query: 473  QELSRKDTE---LLALQTKLETLTNQFSD-------SKQHIEVLKESL----TAKEQRAA 518
             +L+ ++ +   L  ++ K E + +   +       ++Q +E  K  L    T  + + A
Sbjct: 1013 SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIA 1072

Query: 519  ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQK 578
             LQ ++D L+L+L +KE  L     +  D    K      + +L       + ++  LQ+
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL-------QAQIAELQE 1125

Query: 579  KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR 638
              E+ +      EKQ   L E +++L+ +  +T       +E   ++E+ +  LK     
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK----- 1180

Query: 639  DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASS--GLKKDSRL 696
              +  +EE  N++  ++D++++ +    +LSE+   L   K   ++L  +  GL+ D++ 
Sbjct: 1181 --KALEEETKNHEAQIQDMRQRHATALEELSEQ---LEQAKRFKANLEKNKQGLETDNK- 1234

Query: 697  KTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQA 756
               E+A E K  + +K ES+ K+     L+A+   E+  ++   +R      +++SK Q 
Sbjct: 1235 ---ELACEVKVLQQVKAESEHKR---KKLDAQVQ-ELHAKVSEGDRLRVELAEKASKLQN 1287

Query: 757  EVDRLLEILKEVENEKNDKDKKIAELERQVKD-------QNKKVANLKHK-EQVEKKKSA 808
            E+D +  +L+E E +     K  A LE Q++D       + ++  NL  +  Q+E++K++
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 809  QMLEEARRREDNLNDSSQ------QLQDSLRKKDD---RIEELEEALRESV-------QI 852
               ++    E   N   Q      QL D+ +K DD    IE LEEA ++ +       Q 
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR 1407

Query: 853  TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL 912
              E+ +   + E  +   ++++++L + ++  +Q   +++ K     Q LAE+++     
Sbjct: 1408 LEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARY 1467

Query: 913  RAER-----------------RKHLEEVLEMKQE------ALLAAI-----SEKDANIAL 944
              ER                  + LEE LE K+E       L A +     S+ D    +
Sbjct: 1468 AEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNV 1527

Query: 945  LELSSSKKKTQEEVAALKREKDRLVQQL------KQQTQNRMKLMADNYEDDHFKSSHSN 998
             EL  SK+  +++V  ++ + + L  +L      K + +  M+ M   +E D       N
Sbjct: 1528 HELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQN 1587

Query: 999  QTNHKPSPDQIIQPLLELDQNRSKLKLYI 1027
            +   +    Q+ +   EL+  R +  L +
Sbjct: 1588 EEKKRLLIKQVRELEAELEDERKQRALAV 1616



 Score =  144 bits (363), Expect = 5e-34
 Identities = 167/829 (20%), Positives = 354/829 (42%), Gaps = 77/829 (9%)

Query: 151  IMDLQTQLKEVLREND---LLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
            + +LQ Q+ E+  + +     R   E ++  LS  + ++KT     L    A ++    +
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKR 1172

Query: 208  ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
                 E  + ++EE ++ +  IQ ++     QR    L +        +   A L E+N 
Sbjct: 1173 EQEVAELKKALEEETKNHEAQIQDMR-----QRHATALEELSEQLEQAKRFKANL-EKNK 1226

Query: 268  QRLHAEHERQAKELFLLRKTLEEME---LRIETQKQTLNARDESIKKLLEMLQSKGLSAK 324
            Q L  +++  A E+ +L++   E E    +++ Q Q L+A+     +L   L  K  ++K
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK--ASK 1284

Query: 325  ATEEDHERTRRLAEAEMH----VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL 380
               E    +  L EAE           SL  Q +    +L+EE  ++      S++ + L
Sbjct: 1285 LQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL---SSRIRQL 1341

Query: 381  QTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV 440
            +        +    E   ++LE+++  L+S  A + ++ ++++  +E      K +    
Sbjct: 1342 EEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDA 1401

Query: 441  EQLKEELSSKEAQWEELKKKAAGLQAEIG----------QVKQELSRKDTELLALQTKLE 490
            E L + L  K   +++L+K    LQ E+           QV   L +K  +   L  + +
Sbjct: 1402 EALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEK 1461

Query: 491  TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 550
            +++ ++++ +   E        KE +A  L   ++      EE E    +    ++D+  
Sbjct: 1462 SISARYAEERDRAEA---EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518

Query: 551  EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 610
             K      +H+L+      E++V  ++ ++E L+++L+  E     L+  +++++A    
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF-- 1576

Query: 611  TDTALTTLEEALAEKERT----IERLKEQRDRDEREKQEEIDNYKK---DLKDLKEKVSL 663
             +  L T +E   EK+R     +  L+ + + + +++   + + KK   DLKDL+ ++  
Sbjct: 1577 -ERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEA 1635

Query: 664  --------------LQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
                          LQ  + + +  L + +     + +   + + +LK+LE  + Q +EE
Sbjct: 1636 ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEE 1695

Query: 710  CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
                E   + A +         E++D I +     +   DE  + +A + +L E L+E +
Sbjct: 1696 LASSERARRHAEQER------DELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 770  NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQ 829
            +     + +  +   QV   N ++A     E+   +KS    ++  R+   L    Q+L+
Sbjct: 1750 SNMELLNDRFRKTTLQVDTLNAELA----AERSAAQKSDNARQQLERQNKELKAKLQELE 1805

Query: 830  DSLRKK--------DDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAM 881
             +++ K        + +I +LEE L +  +  A    ++ + E        QVE+     
Sbjct: 1806 GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHA 1865

Query: 882  EKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 930
            ++ K+++E   A++   ++ L E E   T   A RRK L+  L+   EA
Sbjct: 1866 DQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRK-LQRELDDATEA 1913



 Score =  139 bits (350), Expect = 1e-32
 Identities = 169/795 (21%), Positives = 350/795 (44%), Gaps = 117/795 (14%)

Query: 152  MDLQTQ-LKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
            +D Q Q L   + E D LR ++  K SKL + ++++ T      KK     KD AS  + 
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316

Query: 211  WKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
             ++   ++QEE +           +L +   + QL ++ +S +  +       EE   R 
Sbjct: 1317 LQDTQELLQEETRQ----------KLNLSSRIRQLEEEKNSLQEQQE------EEEEARK 1360

Query: 271  HAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ--SKGLSAKATEE 328
            + E     K++  L+  L + + +++    T+ + +E+ KKLL+  +  S+ L  KA   
Sbjct: 1361 NLE-----KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 329  DH-ERTRRLAEAEM--------HVHHLESLLEQKEKE-NSMLREE--MHRRFENAPDSAK 376
            D  E+T+   + E+        H   + S LE+K+K+ + +L EE  +  R+    D A+
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475

Query: 377  TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFM 436
             +A +     K++K  S+ R L                     EE ++  E +   +K +
Sbjct: 1476 AEARE-----KETKALSLARAL---------------------EEALEAKEEFERQNKQL 1509

Query: 437  KNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQF 496
            +  +E L            EL+K    L+ ++ +++ +L   + EL A +          
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATE---------- 1559

Query: 497  SDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA 556
             D+K  +EV  +++ A+ +R   LQT  +    + EEK+ +L K+ ++++   E++  Q 
Sbjct: 1560 -DAKLRLEVNMQAMKAQFERD--LQTRDE----QNEEKKRLLIKQVRELEAELEDERKQR 1612

Query: 557  G-----------EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
                        ++ DL+  ++   +  + + K++  LQ Q++D ++++   +     + 
Sbjct: 1613 ALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIF 1672

Query: 606  ADTTNTDTALTTLEEALAEKERTI---ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVS 662
            A +  ++  L +LE  + + +  +   ER +   +++  E  +EI N       L ++  
Sbjct: 1673 AQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKR 1732

Query: 663  LLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHE 722
             L+  +++ E  L + + +   L     K   ++ TL   L  ++    K ++  ++   
Sbjct: 1733 RLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLE- 1791

Query: 723  AALEARASPEMSDRIQHLEREI-TRYKDESSKAQAEVDRLLEILKEVENEK-------ND 774
                 R + E+  ++Q LE  + +++K   S  +A++ +L E L++   E+         
Sbjct: 1792 -----RQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRR 1846

Query: 775  KDKKIAELERQVKDQNKKVANLKHKEQVEK-----KKSAQMLEEARRREDNLNDSSQQLQ 829
             +KK+ E+  QV+D+ +     ++KEQ+EK     K+  + LEEA       N S ++LQ
Sbjct: 1847 TEKKLKEIFMQVEDERRHAD--QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQ 1904

Query: 830  DSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELE 889
               R+ DD  E  E   RE   +            S+  +  +Q+     ++E    + E
Sbjct: 1905 ---RELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTE 1961

Query: 890  SMKAKLSSTQQSLAE 904
            S  + ++ TQ   +E
Sbjct: 1962 SKTSDVNETQPPQSE 1976



 Score =  101 bits (251), Expect = 5e-21
 Identities = 138/657 (21%), Positives = 273/657 (41%), Gaps = 76/657 (11%)

Query: 146  ARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKE 197
            +R   + + +  L+E   E +  RK++E +   L S +   K        T  S E  K+
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395

Query: 198  RALRKDEASKITIWKEQ--YRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSS--- 252
            + L+  EA    + ++   Y  +++    +Q  +  L  +L  QR +    ++       
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455

Query: 253  -RTGEPCVAELTEENFQRLHAE-HERQAKELFLLRKTLEEMELRIETQKQT--------- 301
                E  ++    E   R  AE  E++ K L L R   E +E + E ++Q          
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMED 1515

Query: 302  -LNARDESIKKLLEMLQSKGLSAKATEEDHERTRRL---------AEAEMHVH------- 344
             ++++D+  K + E+ +SK    +  EE   +   L         A+  + V+       
Sbjct: 1516 LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQ 1575

Query: 345  ---HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDL 401
                L++  EQ E++  +L +++        D  K +AL    + K      ME  L+DL
Sbjct: 1576 FERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKK------MEIDLKDL 1629

Query: 402  EEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKA 461
            E +I+        + + R+E +KQ+   ++  K  + ++E+ +       AQ +E +KK 
Sbjct: 1630 EAQIEA-------ANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKL 1682

Query: 462  AGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQ 521
              L+AEI Q+++EL+  +      + + + L ++ ++S      L +     E R A L+
Sbjct: 1683 KSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE 1742

Query: 522  TEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE 581
             E++  +  +E       K T Q+  +  E   +        +     ER+   L+ K++
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQ 1802

Query: 582  NLQEQLRDKEK-QMSSLKERVKSLQADTTNTDTALTTLEEALAEK--ERTIERLKEQRDR 638
             L+  ++ K K  +S+L+ ++  L+             E A A K   RT ++LKE   +
Sbjct: 1803 ELEGAVKSKFKATISALEAKIGQLEEQLEQ-----EAKERAAANKLVRRTEKKLKEIFMQ 1857

Query: 639  DEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKT 698
             E E++   D YK+ ++    ++  L+  L E E       E A+   +S  K    L  
Sbjct: 1858 VEDERR-HADQYKEQMEKANARMKQLKRQLEEAE-------EEATRANASRRKLQRELDD 1909

Query: 699  LEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQ 755
               A E    E   ++++L++    +    +S     R  HLE       D+ ++++
Sbjct: 1910 ATEANEGLSREVSTLKNRLRRGGPISF---SSSRSGRRQLHLEGASLELSDDDTESK 1963



 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 73/323 (22%), Positives = 142/323 (43%), Gaps = 40/323 (12%)

Query: 796  LKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIE-ELEEALRESVQITA 854
            L+H +        + L +  R+E+ L    ++L   +++K  ++E ELEE  R+  Q+  
Sbjct: 829  LRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL-KVKEKQTKVEGELEEMERKHQQLLE 887

Query: 855  EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA 914
            E+  +LA++  A T    + EE+   +   KQELE +   L S  +   E+   L N + 
Sbjct: 888  EKN-ILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946

Query: 915  ERRKHLEEV-------------LEMKQEALLAAISEKDANIALLELSSSK----KKTQE- 956
            + + H++++             L++++    A I + +  I LLE  +SK    KK  E 
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMED 1006

Query: 957  ---EVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 1013
               E ++   E++   + L  + +N+ ++M  + E+   K   + Q   K +  ++    
Sbjct: 1007 RIAECSSQLAEEEEKAKNL-AKIRNKQEVMISDLEERLKKEEKTRQELEK-AKRKLDGET 1064

Query: 1014 LELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTR---- 1069
             +L    ++L+  I  L      ++  +   L         DD+   +N   K+ R    
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALA------RGDDETLHKNNALKVVRELQA 1118

Query: 1070 --GQLQD--ELEKGERDNAELQE 1088
               +LQ+  E EK  R+ AE Q+
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQK 1141


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  149 bits (377), Expect = 1e-35
 Identities = 206/908 (22%), Positives = 388/908 (42%), Gaps = 128/908 (14%)

Query: 157  QLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKERALRKDE--AS 206
            +L E L E + +  ++  K+  L    +S+K        T    E +K     K +  + 
Sbjct: 925  ELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSE 984

Query: 207  KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRD-------LNQLFQQDSSSRTGEPCV 259
            ++T  +E    + +E + +Q   Q   D+L+++ D       +N   +Q +    G    
Sbjct: 985  EMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEG---- 1040

Query: 260  AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
               + E  ++L A+ ER  ++L    K  +E  + +E  KQ +  + +  +  L  LQ+K
Sbjct: 1041 ---SLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAK 1097

Query: 320  -----GLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
                   S +  ++  E   R+ E E  +    +L  + EK+ S L  E+    E   ++
Sbjct: 1098 IDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEA 1157

Query: 375  AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
            +   + Q  IEM   + +  ++  RDLEE     ++  A   +++ + + ++     + +
Sbjct: 1158 SGATSAQ--IEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQ 1215

Query: 435  FMKNKVEQLKEELSSK-------------------------EAQWEELKKK--------- 460
             +K K+E+ K EL  +                         E Q+ E+K K         
Sbjct: 1216 RVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIH 1275

Query: 461  -----AAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 515
                  A LQ + G++   +  K++ +  L    + LT Q  + K+ +E   E   AK  
Sbjct: 1276 DLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQME---EETKAKNA 1332

Query: 516  RAAILQT---EVDALRLRLEEKETM-------LNKKTKQIQDMAEEKGTQAGEIHDLKDM 565
             A  LQ+   + D LR + EE++         L+K   ++     +  T A  I   +++
Sbjct: 1333 MAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDA--IQRTEEL 1390

Query: 566  LDVKERKVNVLQKKIENLQ---EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
             + K++    LQ+  EN +    +    EK    L+  V+ L  D   + TA  TL++  
Sbjct: 1391 EEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQ 1450

Query: 623  AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
               ++ +   K++ D    E Q E++  +K+ + L  ++  ++    E    L  L+   
Sbjct: 1451 RNFDKVLAEWKQKLD----ESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRREN 1506

Query: 683  SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLER 742
             +L         ++      L Q+ E+  K+  Q K   + ALE     E+   ++H E 
Sbjct: 1507 KNLQEEISDLTEQIAETGKNL-QEAEKTKKLVEQEKSDLQVALE-----EVEGSLEHEES 1560

Query: 743  EITRYKDESSKAQAEVDR-LLEILKEVENEKNDKDKKIAELERQVKDQNKKVAN--LKHK 799
            +I R + E S+ ++E+DR ++E  +E+E  K +  ++ AE  + V D   +  N  L+ K
Sbjct: 1561 KILRVQLELSQVKSELDRKVIEKDEEIEQLKRNS-QRAAEALQSVLDAEIRSRNDALRLK 1619

Query: 800  EQVE-------------KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 846
            +++E              ++ A+  +  R  +  L DS   L D+LR  +D  E+L    
Sbjct: 1620 KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVE 1679

Query: 847  RESVQITAE-REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEK 905
            R +  +  E  EM +A E++ RT    + +ELL A ++V Q L S    L +T++ L   
Sbjct: 1680 RRNGLLLEELEEMKVALEQTERTRRLSE-QELLDASDRV-QLLHSQNTSLINTKKKL--- 1734

Query: 906  ETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREK 965
            E  +   +AE    ++E    +++A  A     DA +   EL    KK Q+  A L+R K
Sbjct: 1735 EADIAQCQAEVENSIQESRNAEEKAKKAI---TDAAMMAEEL----KKEQDTSAHLERMK 1787

Query: 966  DRLVQQLK 973
              L Q +K
Sbjct: 1788 KNLEQTVK 1795



 Score =  147 bits (371), Expect = 5e-35
 Identities = 185/851 (21%), Positives = 375/851 (44%), Gaps = 109/851 (12%)

Query: 319  KGLSAKATEEDHERTRRL--AEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
            KG  ++    D ++  R+  A A      ++S    ++  NS+  +    RF N     K
Sbjct: 711  KGFPSRILYADFKQRYRILNASAIPEGQFIDSKNASEKLLNSIDVDREQFRFGNTKVFFK 770

Query: 377  TKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME----VYRSH 432
               L  + EM+D K+ ++    + +          G L   E ++ M++ +    +  + 
Sbjct: 771  AGLLGLLEEMRDEKLVTLMTSTQAV--------CRGYLMRVEFKKMMERRDSIFCIQYNI 822

Query: 433  SKFMK-------NKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLAL 485
              FM        N   ++K  L S EA+     K+ A ++ +  + K+EL+R +     L
Sbjct: 823  RSFMNVKHWPWMNLFFKIKPLLKSAEAE-----KEMATMKEDFERTKEELARSEARRKEL 877

Query: 486  QTKLETLTNQFSDSKQHIEVLKESLTAKEQRAA-------ILQTEVDALRLRLEEKETML 538
            + K+ +L  + +D +  ++   E+L   E+R         +L+ +V  L  RLEE+E M 
Sbjct: 878  EEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMN 937

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
            ++   + +++ ++  +   +I DL+  L   E++ +  + K++NL E++   E+ +S L 
Sbjct: 938  SELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLT 997

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK 658
            +  KSLQ     T   L   E+ +    +   +L++Q D  E   ++E    KK   DL+
Sbjct: 998  KEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQE----KKLRADLE 1053

Query: 659  EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK 718
                 L+GDL   + S++DL+     +     KK+  L  L+  ++ ++   L+ + ++K
Sbjct: 1054 RAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIK 1113

Query: 719  KAH------------EAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK 766
            +              E  L A+   + SD  + LE    R ++ S    A+++  +   +
Sbjct: 1114 ELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIE--MNKKR 1171

Query: 767  EVENEKNDKDKKIAELERQV------KDQNKKVANL--------KHKEQVEKKKSAQMLE 812
            E E +K  +D + A L+ +       K Q   VA L        + K+++EK+KS   +E
Sbjct: 1172 EAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKME 1231

Query: 813  --EARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
              +     + L+ S   ++ + R  +D+  E++    +  Q+  +  M  A+ ++     
Sbjct: 1232 IDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGEL 1291

Query: 871  EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRA---ERRKH----LEEV 923
              +VEE    + ++ +  +++  +L   ++ + E+ET   N  A   +  +H    L E 
Sbjct: 1292 SHRVEEKESLISQLTKSKQALTQQLEELKRQM-EEETKAKNAMAHALQSSRHDCDLLREQ 1350

Query: 924  LEMKQEA---LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRM 980
             E +QEA   L  A+S+ ++ +A       + +T+ E  A++R ++  +++ K++   R+
Sbjct: 1351 YEEEQEAKAELQRALSKANSEVA-------QWRTKYETDAIQRTEE--LEEAKKKLAQRL 1401

Query: 981  KLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPL 1040
            +   +N E  + K +   +T  +   +  ++ L+  D  RS       H      D+   
Sbjct: 1402 QEAEENTETANSKCASLEKTKQRLQGE--VEDLMR-DLERS-------HTACATLDKKQR 1451

Query: 1041 ILRGLTPPASYNLDDDQAAWE----------NELQKMTRG--QLQDELEKGERDNAELQE 1088
                +       LD+ QA  E           EL KM     ++ D+LE   R+N  LQE
Sbjct: 1452 NFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQE 1511

Query: 1089 FANAILQQIAD 1099
              + + +QIA+
Sbjct: 1512 EISDLTEQIAE 1522



 Score =  132 bits (333), Expect = 1e-30
 Identities = 184/931 (19%), Positives = 395/931 (42%), Gaps = 111/931 (11%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDL---LRKDVEVKES------KLSSSMNSIKTFW--- 190
            L + RD  ++ L T  + V R   +    +K +E ++S       + S MN     W   
Sbjct: 777  LEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWPWMNL 836

Query: 191  ---------SPELKKERALRKD--EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQ 239
                     S E +KE A  K+  E +K  + + + R  + E + + +  +    +L++Q
Sbjct: 837  FFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQ 896

Query: 240  RDLNQLFQQDS-------SSRTGEPCVAELTEENFQRLHAEHERQAKELFL------LRK 286
             +   L   +        S    E  V ELTE   +      E  AK+  L      L++
Sbjct: 897  SETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKR 956

Query: 287  TLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEA--EMHVH 344
             ++++EL +   ++  +A +  +K L E +        A EE+  +  +  ++  E H  
Sbjct: 957  DIDDLELTLTKVEKEKHATENKVKNLSEEMT-------ALEENISKLTKEKKSLQEAHQQ 1009

Query: 345  HLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEE 404
             L+ L  +++K N +++        NA    +T  L+  +E +    + +ER  R LE +
Sbjct: 1010 TLDDLQVEEDKVNGLIKI-------NAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGD 1062

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
            ++M +     S  + E + +Q+E      +F   ++ QL+ ++  ++    + +KK   L
Sbjct: 1063 LKMSQE----SIMDLENDKQQIEEKLKKKEF---ELSQLQAKIDDEQVHSLQFQKKIKEL 1115

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEV 524
            QA I ++++E+  + T    ++ +   L  +  +  + +E    + +A+ +     + E 
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175

Query: 525  DALRLRLEEKE--------TMLNKKTKQIQDMAEE-------KGTQAGEIHDLKDMLDVK 569
              +R  LEE          T+  K+   + ++ E+       K     E  +LK  +D  
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKER-------VKSLQADTTNTDTALTTLEEAL 622
               +  L K   N++   R  E Q S +K +       +  L        T    L   +
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRV 1295

Query: 623  AEKERTIERLKEQRDR-----DEREKQEEIDNYKKD-----LKDLKEKVSLLQGDLSEKE 672
             EKE  I +L + +       +E ++Q E +   K+     L+  +    LL+    E++
Sbjct: 1296 EEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQ 1355

Query: 673  ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE 732
             +  +L+   S   S   +  ++ +T  I   Q+ EE   +E   KK  +   EA  + E
Sbjct: 1356 EAKAELQRALSKANSEVAQWRTKYETDAI---QRTEE---LEEAKKKLAQRLQEAEENTE 1409

Query: 733  MSD-RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNK 791
             ++ +   LE+   R + E      +++R       ++ ++ + DK +AE ++++ +   
Sbjct: 1410 TANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQA 1469

Query: 792  KVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
            ++       +  +K+S  +  E  +  +   +   QL+ +LR+++  ++E    L E + 
Sbjct: 1470 EL-------EAAQKESRSLSTELFKMRNAYEEVVDQLE-TLRRENKNLQEEISDLTEQIA 1521

Query: 852  ITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN 911
             T +    L + E  +   E++  +L +A+E+V+  LE  ++K+   Q  L++ ++ L  
Sbjct: 1522 ETGKN---LQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDR 1578

Query: 912  LRAERRKHLEEVLEMKQEALLAAISEKDANI-ALLELSSSKKKTQEEVAALKREKDRLVQ 970
               E+ + +E++    Q A  A  S  DA I +  +    KKK + ++  ++ +     +
Sbjct: 1579 KVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNR 1638

Query: 971  QLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
            Q+  +TQ  ++ +    +D       + ++N
Sbjct: 1639 QM-AETQKHLRTVQGQLKDSQLHLDDALRSN 1668



 Score =  125 bits (315), Expect = 2e-28
 Identities = 157/824 (19%), Positives = 337/824 (40%), Gaps = 96/824 (11%)

Query: 141  HSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERAL 200
            H+LR   +    DL  +L+E+   ++ L +      +++  +      F       E A 
Sbjct: 1130 HTLRAKIEKQRSDLARELEEI---SERLEEASGATSAQIEMNKKREAEFQKMRRDLEEAT 1186

Query: 201  RKDEASKITIWKEQYRVVQEEN------QHMQMTIQALQDELRIQ-RDLNQLFQQDSSSR 253
             + EA+  T+ K+Q   V E        Q ++  ++  + EL+++  D+    +  S S+
Sbjct: 1187 LQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSK 1246

Query: 254  TGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL 313
            +         E+ F  + A+ E+Q +    L   L   + R++TQ   L+ R E  + L+
Sbjct: 1247 SNIERTCRTVEDQFSEIKAKDEQQTQ----LIHDLNMQKARLQTQNGELSHRVEEKESLI 1302

Query: 314  EMLQSKGLSA--------KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
              L     +         +  EE+ +    +A A     H   LL ++ +E    + E+ 
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362

Query: 366  RRFENAPDSA-------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
            R    A           +T A+Q   E++++K    +R L++ EE  +   S  A S E+
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQEAEENTETANSKCA-SLEK 1420

Query: 419  REEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
             ++ ++              +VE L  +L         L KK       + + KQ+L   
Sbjct: 1421 TKQRLQ-------------GEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
              EL A Q +  +L+ +    +   E + + L    +    LQ E+  L  ++ E    L
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNL 1527

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
             +  K  + + +EK      + +++  L+ +E K+  +Q ++  ++ +L   ++++    
Sbjct: 1528 QEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL---DRKVIEKD 1584

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK 658
            E ++ L+ ++     AL ++ +A         RLK++ + D  E + ++ +  + + + +
Sbjct: 1585 EEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQ 1644

Query: 659  EKVSLLQGDLSEKEASL-------LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 711
            + +  +QG L + +  L        DLKE  + +          L+ +++ALEQ +    
Sbjct: 1645 KHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRR 1704

Query: 712  KMESQL--------------------KKAHEAALEARASPEMSDRIQHLEREITRYK--- 748
              E +L                    KK  EA + A+   E+ + IQ       + K   
Sbjct: 1705 LSEQELLDASDRVQLLHSQNTSLINTKKKLEADI-AQCQAEVENSIQESRNAEEKAKKAI 1763

Query: 749  -------DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE--------RQVKDQNKKV 793
                   +E  K Q     L  + K +E    D   ++ E E        +Q++    +V
Sbjct: 1764 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRV 1823

Query: 794  ANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD---SLRKKDDRIEELEEALRESV 850
              L+++  VE+K+ A+ L+ A + E  + + + Q ++   ++ +  D +++L+  ++   
Sbjct: 1824 RELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYK 1883

Query: 851  QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 894
            +   E E     + S     + ++EE     +  + ++  ++AK
Sbjct: 1884 RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927



 Score =  108 bits (271), Expect = 2e-23
 Identities = 148/694 (21%), Positives = 296/694 (42%), Gaps = 98/694 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKESKLSS----------SMNSIKTFWSPELKKERAL 200
            I DL  Q   +  +N  L   VE KES +S            +  +K     E K + A+
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM 1333

Query: 201  R---KDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEP 257
                +       + +EQY   QE    +Q  +     E+   R     ++ D+  RT E 
Sbjct: 1334 AHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTK---YETDAIQRTEE- 1389

Query: 258  CVAELTEENFQRLHAEHERQA---KELFLLRKTLEEMELRIE----------TQKQTLNA 304
             + E  ++  QRL    E       +   L KT + ++  +E          T   TL+ 
Sbjct: 1390 -LEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK 1448

Query: 305  RDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH---------VHHLESLLEQK-- 353
            +  +  K+L   + K   ++A  E  ++  R    E+          V  LE+L  +   
Sbjct: 1449 KQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKN 1508

Query: 354  -EKENSMLREEMHRRFENAPDSAKTKAL--------QTVIEMKDSKISSMERGLRDLEEE 404
             ++E S L E++    +N  ++ KTK L        Q  +E  +  +   E  +  ++ E
Sbjct: 1509 LQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLE 1568

Query: 405  IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGL 464
            +  +KS       E++EE++Q++  R+  +  +     L  E+ S+      LKKK  G 
Sbjct: 1569 LSQVKSELDRKVIEKDEEIEQLK--RNSQRAAEALQSVLDAEIRSRNDALR-LKKKMEG- 1624

Query: 465  QAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI-------EVLKESLTAKEQRA 517
              ++ +++ +L   + ++   Q  L T+  Q  DS+ H+       E LKE L   E+R 
Sbjct: 1625 --DLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRN 1682

Query: 518  AILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQ 577
             +L  E++ +++ LE+ E       +++ D ++       +   L +     E  +   Q
Sbjct: 1683 GLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742

Query: 578  KKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT---IERLKE 634
             ++EN  ++ R+ E+            +A    TD A+  + E L +++ T   +ER+K+
Sbjct: 1743 AEVENSIQESRNAEE------------KAKKAITDAAM--MAEELKKEQDTSAHLERMKK 1788

Query: 635  QRDRDEREKQEEIDNYKK-DLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKK- 692
              ++  ++ Q  +D  ++  LK  K+++  L+  + E E + LD+++   + A  G  K 
Sbjct: 1789 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE-NELDVEQKRGAEALKGAHKY 1847

Query: 693  DSRLKTLEIALEQKKEECL-----------KMESQLKKAHEAALEARASPEMSDRIQHLE 741
            + ++K +    E+  +  L           K++S  ++A EA  +A        R+QH  
Sbjct: 1848 ERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH-- 1905

Query: 742  REITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
             E+    + +  A+++V++L    ++V ++K ++
Sbjct: 1906 -ELEEAAERADIAESQVNKLRAKSRDVGSQKMEE 1938


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score =  149 bits (375), Expect = 2e-35
 Identities = 217/1080 (20%), Positives = 436/1080 (40%), Gaps = 209/1080 (19%)

Query: 154  LQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR-KDEA--SKITI 210
            L+ +L+++  EN+  ++ + +   K S  M  +       LK E  L  KDE    K ++
Sbjct: 419  LKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELENKDEILRDKFSL 478

Query: 211  WKEQYRV---VQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENF 267
              E   +   V  +N+ + +  Q ++      R L ++  Q    R      + L++   
Sbjct: 479  MNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYLSKYQM 538

Query: 268  QRLHAEHER-----QAKELFL----LRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
                 + +R     +A +L +    ++  ++E E++      T N   +S+    +  +S
Sbjct: 539  SSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQES 598

Query: 319  KGLSAKATEE----DHERTRRLAEAEMH----------------VHHLESLLEQKEKENS 358
              LS+  TE      H+    + +   H                +  L + L Q E ENS
Sbjct: 599  SKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENS 658

Query: 359  MLREEMHRR-----------FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQM 407
             L+  M  R            E A +S+K   L++ +  K S++ ++E+    LEE+I  
Sbjct: 659  DLKVNMAHRTSQFQLIQEELLEKASNSSK---LESEMTKKCSQLLTLEK---QLEEKIVA 712

Query: 408  LKSNGALSTEEREEEMKQMEVYRS--------HSKF-----------------MKNKVEQ 442
              S  A + E  +E M++ E  RS        H K                  M+ ++E+
Sbjct: 713  YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIER 772

Query: 443  LKEELSSKEAQWEELKKKAAGLQAEI------------------GQVKQELSRKDTELLA 484
            L+ +L  K+ Q++E +K  + LQ +I                  G++K+E  +KD  L A
Sbjct: 773  LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKA 832

Query: 485  LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 544
            LQ ++   T +       +E+ KE L             ++ L    E+ E  L KK+++
Sbjct: 833  LQNQVSEETIKVRQLDSALEICKEELVL----------HLNQLEGNKEKFEKQLKKKSEE 882

Query: 545  IQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSL 604
            +  + +E   +    H L++     E+ V +LQ  ++  Q+ L+ +  +   L++    L
Sbjct: 883  VYCLQKELKIKN---HSLQE---TSEQNV-ILQHTLQQQQQMLQQETIRNGELEDTQTKL 935

Query: 605  QADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLL 664
            +   +  +  L    E+ AEK R +E   E    +   K++++       + +K ++   
Sbjct: 936  EKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQY 995

Query: 665  QGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAA 724
            + +LS+ E  ++ LK         G  K   L  L++ L+Q K E  K  + +K+  +  
Sbjct: 996  KEELSKMEKEIMHLKR-------DGENKAMHLSQLDMILDQTKTELEKKTNAVKELEK-- 1046

Query: 725  LEARASPEMSDRIQHLE-----------------REITRYKDESSKAQAEVDR------- 760
            L+     E+++ +Q  E                 R++   +D   KAQ  ++        
Sbjct: 1047 LQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKD 1106

Query: 761  LLEILKEVENEKNDKDKKIAELERQVKDQN----KKVANLKHKEQVEKKKSAQMLEEARR 816
            L   L+E + E  DK +++ E+++ +K++N    ++ A + H +   ++   +M ++  +
Sbjct: 1107 LTAELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIK 1166

Query: 817  REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEE 876
             E  L  S  +L++     + +IE L + L+ + +   E+E ++ Q E            
Sbjct: 1167 LEGTLEKSELELKEC----NKQIESLNDKLQNAKEQLREKEFIMLQNE------------ 1210

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAIS 936
                     QE+  +K ++  TQQ + E E+ +           +E +++ QE  L    
Sbjct: 1211 ---------QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQ 1261

Query: 937  EKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSH 996
             ++++  L E    + + Q E+  L  E + + Q  K+                  K +H
Sbjct: 1262 VQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKE------------------KDAH 1303

Query: 997  SNQTNHKPSPDQIIQPLLE--LDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLD 1054
             N    +    ++ +  LE  +     KL   +  L    H                +  
Sbjct: 1304 GNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHME------------MISHQ 1351

Query: 1055 DDQAAWE--NELQKMTRGQLQDELEKGERDNAELQEFANAILQQIADHCPDILEQVVNAL 1112
            ++ A W+   + QK +  QL ++LEK + +  E Q+  + + QQ+ D   +++E    AL
Sbjct: 1352 ENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDR-NEVIEAANEAL 1410



 Score =  134 bits (336), Expect = 6e-31
 Identities = 181/850 (21%), Positives = 358/850 (42%), Gaps = 106/850 (12%)

Query: 104  MTAMGSSPNIASSGVASDTIAFGEHHLPPVSMASTVPHSL-------RQARDNTIMDLQT 156
            +T   S  +   S + ++ +  G H +   S+     H++       RQ     I +L+T
Sbjct: 590  ITCNDSQESSKLSSLETEPVKLGGHQVAE-SVKDQNQHTMNKQYEKERQRLVTGIEELRT 648

Query: 157  QLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKE--- 213
            +L ++  EN  L+ ++  + S+       +    S   K E  + K  +  +T+ K+   
Sbjct: 649  KLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEE 708

Query: 214  ---QYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRL 270
                Y  +  +N  ++  +    +++R         + + ++   + C+A    E  +++
Sbjct: 709  KIVAYSSIAAKNAELEQELMEKNEKIRS-------LETNINTEHEKICLAF---EKAKKI 758

Query: 271  HAE-HERQAKELFLLRKTLEEMELRIETQKQTLNARDESI---KKLLEML-----QSKGL 321
            H E H+   K++  L   LE+ + + + Q++T++   + I   +  LE L     +SKG 
Sbjct: 759  HLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGE 818

Query: 322  SAKATEEDHERTRRL----AEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT 377
              K   +  E  + L    +E  + V  L+S LE  ++E  +   ++    E      K 
Sbjct: 819  MKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKK 878

Query: 378  KALQTVIEMKDSKISS------MERGL---RDLEEEIQMLKS----NGALSTEE------ 418
            K+ +     K+ KI +       E+ +     L+++ QML+     NG L   +      
Sbjct: 879  KSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQ 938

Query: 419  ----REEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE 474
                 +E  KQ E      + M+ K E    E   K  +  EL   A  ++ E+ Q K+E
Sbjct: 939  VSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEE 998

Query: 475  LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEK 534
            LS+ + E++ L+   E      S     ++  K  L  K      L+    +    L E 
Sbjct: 999  LSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEA 1058

Query: 535  ETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLR------ 588
                     ++Q+   E  +   ++ +L+D+L   +  +      I++L  +LR      
Sbjct: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118

Query: 589  -DKEKQM----SSLKER---VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDE 640
             DK++++     +LKER   +K   A  T+ D    T+ E   E E+ I +L+   ++ E
Sbjct: 1119 EDKKQELLEMDQALKERNWELKQRAAQVTHLD---MTIREHRGEMEQKIIKLEGTLEKSE 1175

Query: 641  REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLE 700
             E +E      K ++ L +K+   +  L EKE  +L  ++  S L     +   R+K +E
Sbjct: 1176 LELKE----CNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEME 1231

Query: 701  IALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDR 760
              ++++++    + +Q K+A +   E R + E   ++Q+   E+   + +  +AQ E++R
Sbjct: 1232 SVMKEQEQ---YIATQYKEAIDLGQELRLTRE---QVQNSHTELAEARHQQVQAQREIER 1285

Query: 761  LLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKK---SAQMLEEARRR 817
            L   L++++    +KD     L  ++     + A+L+ + Q E KK     + L+EA   
Sbjct: 1286 LSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHM 1345

Query: 818  E---------------DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAER-EMVLA 861
            E               D+   S QQL + L K    +EE ++ +    Q   +R E++ A
Sbjct: 1346 EMISHQENHAKWKISADSQKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEA 1405

Query: 862  QEESARTNAE 871
              E+  T  E
Sbjct: 1406 ANEALLTKGE 1415



 Score =  128 bits (321), Expect = 3e-29
 Identities = 167/871 (19%), Positives = 387/871 (44%), Gaps = 94/871 (10%)

Query: 168  LRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQM 227
            L  +V  ++  L  + N ++      ++KE++L++ +   I +  +     ++  +  + 
Sbjct: 296  LEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAERQ 355

Query: 228  TIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKT 287
              +AL +   + +   Q  ++ +          E+ E N      E++R  +   L +  
Sbjct: 356  RNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNCEKENKRLQERCGLYKSE 415

Query: 288  LEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLE 347
            LE ++ ++   K+  N   E ++ +               ++ E   +L E+   +  LE
Sbjct: 416  LEILKEKLRQLKEENNNGKEKLRIM-------------AVKNSEVMAQLTESRQSILKLE 462

Query: 348  SLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQM 407
            S LE K++   +LR++     EN     +  A    +++   +I S    LR LE+ I  
Sbjct: 463  SELENKDE---ILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQ 519

Query: 408  LKSNGALSTEEREEEMKQMEVYRSHS-------KFMKNKVEQLKEELSSKEAQWEELKKK 460
            L     L   +      QM  + +         +  K  + +L+ +L+ KEA+ ++L   
Sbjct: 520  LPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHAN 579

Query: 461  AAGLQAEIGQVKQELSRKDTELLALQTKLETL-----------TNQFSDSKQHIEVLKES 509
                Q     +    S++ ++L +L+T+   L            NQ + +KQ+ +  +  
Sbjct: 580  LTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQYEKERQRL 639

Query: 510  LTAKEQ-RAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 568
            +T  E+ R  ++Q E +   L++      +  +T Q Q + EE   +A     L+  +  
Sbjct: 640  VTGIEELRTKLIQIEAENSDLKVN-----MAHRTSQFQLIQEELLEKASNSSKLESEMTK 694

Query: 569  KERKVNVLQKKIE-------NLQEQLRDKEKQMSSLKERVKSLQAD-TTNTDTALTTLEE 620
            K  ++  L+K++E       ++  +  + E+++    E+++SL+ +  T  +      E+
Sbjct: 695  KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEK 754

Query: 621  ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASL--LD- 677
            A   K+  +E+ KE   + ER  + +++   +  K+ ++ +S+LQ D+  K+  L  LD 
Sbjct: 755  A---KKIHLEQHKEMEKQIER-LEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDR 810

Query: 678  -LKEHASSLASSGLKKDSRLKTLE--------------IALEQKKEECLKMESQL---KK 719
             L E    +    +KKD  LK L+               ALE  KEE +   +QL   K+
Sbjct: 811  LLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKE 870

Query: 720  AHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLE--------ILK----- 766
              E  L+ +     S+ +  L++E+ + K+ S +  +E + +L+        +L+     
Sbjct: 871  KFEKQLKKK-----SEEVYCLQKEL-KIKNHSLQETSEQNVILQHTLQQQQQMLQQETIR 924

Query: 767  --EVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 824
              E+E+ +   +K++++LE++++ Q +  A    K + + + +A   +  R++   L  +
Sbjct: 925  NGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGT 984

Query: 825  SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 884
            ++Q++  + +  + + ++E+ +    +    + M L+Q +      + ++E+   A++++
Sbjct: 985  ARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKEL 1044

Query: 885  KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            ++   S + +L+   Q     ET L N   E +  L ++ E++     A +S ++    +
Sbjct: 1045 EKLQHSTETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTI 1104

Query: 945  LELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
             +L++  ++ + E+   K+E   + Q LK++
Sbjct: 1105 KDLTAELRECKMEIEDKKQELLEMDQALKER 1135



 Score = 95.1 bits (235), Expect = 3e-19
 Identities = 168/840 (20%), Positives = 347/840 (41%), Gaps = 132/840 (15%)

Query: 389  SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELS 448
            S  + +++ ++ L E++  L+   A    +    M + E         + KV  L E   
Sbjct: 222  SSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSML-ESAQ 280

Query: 449  SKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQH------ 502
             + A    L+++   L+AE+    + L   + +L   Q  +        +SK+       
Sbjct: 281  QQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKV 340

Query: 503  --IEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
              +E  K+   A+ QR   L    + L    ++ +  + +K +++Q  AEE+  +    +
Sbjct: 341  DLLEQTKQGKRAERQRNEALY-NAEELSKAFQQYKKKVAEKLEKVQ--AEEEILERNLTN 397

Query: 561  DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
              K+   ++ER   + + ++E L+E+LR  +++ ++ KE+++ +    +     LT   +
Sbjct: 398  CEKENKRLQER-CGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQ 456

Query: 621  ALAEKERTIERLKE-QRDR-----DEREK--------------QEEIDNYKKDLKDLKEK 660
            ++ + E  +E   E  RD+     + RE               Q+EI++ + +L+ L++ 
Sbjct: 457  SILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKI 516

Query: 661  VSLL---------QGDLSEKEASLLDLKE-------HASSLASSGLKKDSRLKTLEI--- 701
            +S L         +  LS+ + S    KE        A+ L  S L+    +K  EI   
Sbjct: 517  ISQLPLKRELFGFKSYLSKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKL 576

Query: 702  ----ALEQKKEECLKMESQLKKAHEAALEA--------RASPEMSDRIQHLEREITRYKD 749
                   Q  +  +      + +  ++LE         + +  + D+ QH   +  +Y+ 
Sbjct: 577  HANLTANQLSQSLITCNDSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNK--QYEK 634

Query: 750  ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV----KDQNKKVANLKHKEQVEKK 805
            E  +    ++ L   L ++E E +D    +A    Q     ++  +K +N    E    K
Sbjct: 635  ERQRLVTGIEELRTKLIQIEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTK 694

Query: 806  KSAQMLEEARRRED------NLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMV 859
            K +Q+L   ++ E+      ++   + +L+  L +K+++I  LE        I  E E +
Sbjct: 695  KCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIRSLE------TNINTEHEKI 748

Query: 860  LAQEESAR-------TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTN- 911
                E A+          EKQ+E L   +EK  Q+ +  +  +S  QQ +  K+ HL + 
Sbjct: 749  CLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQQDIICKQHHLESL 808

Query: 912  --LRAERRKHLEEVLEMKQEALLAAISE-KDANIALLELSSSKKKTQEEVA----ALKRE 964
              L  E +  +++    K EAL A  ++  +  I + +L S+ +  +EE+      L+  
Sbjct: 809  DRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGN 868

Query: 965  KDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLL--------EL 1016
            K++  +QLK++++    L  +    +H     S Q        Q  Q +L        EL
Sbjct: 869  KEKFEKQLKKKSEEVYCLQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGEL 928

Query: 1017 DQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDD--DQAAWENELQ--------- 1065
            +  ++KL+  +  L     +++    R  +      +++  + AA E +L+         
Sbjct: 929  EDTQTKLEKQVSKL-----EQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTG 983

Query: 1066 -----KMTRGQLQDELEKGERD------NAELQEFANAILQQIADHCPDILEQVVNALEE 1114
                 K+   Q ++EL K E++      + E +    + L  I D     LE+  NA++E
Sbjct: 984  TARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKE 1043



 Score = 71.2 bits (173), Expect = 5e-12
 Identities = 109/594 (18%), Positives = 229/594 (38%), Gaps = 113/594 (19%)

Query: 147  RDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSI---KTFWSPELKKERALRKD 203
            +D  +  LQ Q+ E   +   L   +E+ + +L   +N +   K  +  +LKK+      
Sbjct: 826  KDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYC 885

Query: 204  EASKITIWKEQYRVVQEENQHMQMTIQALQDEL---------------RIQRDLNQLFQQ 248
               ++ I     +   E+N  +Q T+Q  Q  L               ++++ +++L Q+
Sbjct: 886  LQKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQE 945

Query: 249  DSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES 308
                R          EE  +    E + + +++  L  T  ++++ ++  K+ L+  ++ 
Sbjct: 946  LQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKE 1005

Query: 309  IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH-VHHLESLLEQKEKENS---MLREEM 364
            I  L    ++K +     +   ++T+   E + + V  LE L    E E +     RE +
Sbjct: 1006 IMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVL 1065

Query: 365  HRRFENAPDSAKT------------KALQTVIEMKDSKISSMERGLRDLEEEIQ-----M 407
                +NA    K+            +  Q  +E K + I  +   LR+ + EI+     +
Sbjct: 1066 ETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQEL 1125

Query: 408  LKSNGALSTEEREEEMKQMEVY--------RSHSKFMKNKVEQLKEELSSKEAQWEELKK 459
            L+ + AL  +ER  E+KQ            R H   M+ K+ +L+  L   E + +E  K
Sbjct: 1126 LEMDQAL--KERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNK 1183

Query: 460  KAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAI 519
            +   L  ++   K++L  K+  +L  + ++  L  +   ++Q ++ ++  +  +EQ  A 
Sbjct: 1184 QIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIAT 1243

Query: 520  -----------------------------------LQTEVDALRLRLEEKETMLNKKTKQ 544
                                                Q E++ L   LE+ + +  +K   
Sbjct: 1244 QYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQLSKEKDAH 1303

Query: 545  IQDMAEEKGTQ------------------AGEIHDLKD-----MLDVKER----KVNVLQ 577
               +AEE G                    + E+  LK+     M+  +E     K++   
Sbjct: 1304 GNHLAEELGASKVREAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADS 1363

Query: 578  KK--IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
            +K  ++ L EQL   + ++   ++ V +L     + +  +    EAL  K   +
Sbjct: 1364 QKSSVQQLNEQLEKAKLELEEAQDTVSNLHQQVQDRNEVIEAANEALLTKGENV 1417



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 93/442 (21%), Positives = 185/442 (41%), Gaps = 36/442 (8%)

Query: 579 KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER------- 631
           ++E+      +K+ +  SL   V SL+ +   T+ +L +L E L+    +          
Sbjct: 118 EMESSSSDYYNKDNEEESLLANVASLRHELKITEWSLQSLGEELSSVSPSENSDYAPNPS 177

Query: 632 LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK 691
             E+   D +     + NY        E V  + G  ++ +      K+    + SS   
Sbjct: 178 RSEKLILDVQPSHPGLLNYSP-----YENVCKISGSSTDFQ------KKPRDKMFSSSAP 226

Query: 692 KDSRLKTLEIALEQKKEE--CL-----KMESQLKKAHEAALEARASPEMSDRIQHLEREI 744
            D  +K+L   L + +++  CL      + ++ +  H    ++RA   M +  Q     +
Sbjct: 227 VDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASV 286

Query: 745 TRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLK---HKEQ 801
              +++    +AEV    ++L+E EN+     K + E E+ +++  ++   LK    ++ 
Sbjct: 287 PILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQT 346

Query: 802 VEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLA 861
            + K++ +   EA    + L+ + QQ +  + +K ++++  EE L  ++    E+E    
Sbjct: 347 KQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNL-TNCEKENKRL 405

Query: 862 QEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE 921
           QE      +E  +E L   + ++K+E  + K KL       +E    LT  R    K LE
Sbjct: 406 QERCGLYKSE--LEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILK-LE 462

Query: 922 EVLEMKQEALLAAISEKDANIALLELSSSKKK----TQEEVAALKREKDRLVQQLKQQTQ 977
             LE K E L    S  + N  L    +++ +     Q+E+ + + E   L + + Q   
Sbjct: 463 SELENKDEILRDKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPL 522

Query: 978 NRMKLMADNYEDDHFKSSHSNQ 999
            R      +Y   +  SS SN+
Sbjct: 523 KRELFGFKSYLSKYQMSSFSNK 544


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  146 bits (368), Expect = 1e-34
 Identities = 206/976 (21%), Positives = 421/976 (43%), Gaps = 161/976 (16%)

Query: 172  VEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQA 231
            V  +E ++ +    +      +L  E  L + E  +  +  E+ ++ ++     ++  +A
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899

Query: 232  LQDELRIQRDLNQLFQ--QDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLE 289
             +   R+     +L +   D  +R  E       EE  Q L AE ++  + +  L + LE
Sbjct: 900  EELRARLTAKKQELEEICHDLEARVEEE------EERCQHLQAEKKKMQQNIQELEEQLE 953

Query: 290  EME---LRIETQKQTLNARDESIKK---LLEMLQSKGLSAKATEEDH--ERTRRLAEAEM 341
            E E    +++ +K T  A+ + +++   +LE    K    K   ED   E T  L E E 
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 342  HVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKA--------LQTVIEMKDSKISS 393
                L  L  + E   + L E + R  +   +  KT+         L   I    ++I+ 
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAE 1073

Query: 394  MERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQ 453
            ++  L   EEE+Q      AL+  E E   K M + +     +++++ +L+E+L S+ A 
Sbjct: 1074 LKMQLAKKEEELQ-----AALARVEEEAAQKNMALKKIRE--LESQISELQEDLESERAS 1126

Query: 454  WEELKKKAAGLQAEIGQVKQELSRKDT-ELLALQTKLETLTNQFSDSKQHIEVLKESL-- 510
              + +K+   L  E+  +K EL  +DT +  A Q +L       S  +Q + +LK++L  
Sbjct: 1127 RNKAEKQKRDLGEELEALKTEL--EDTLDSTAAQQELR------SKREQEVNILKKTLEE 1178

Query: 511  TAKEQRAAILQTE------VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKD 564
             AK   A I +        V+ L  +LE+ + +     K  Q +  E+G  A E+  L  
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238

Query: 565  MLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN-------TDTALTT 617
                 E K   ++ +++ LQ +  + E+  + L ++V  LQ +  N       +D+  + 
Sbjct: 1239 GKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK 1298

Query: 618  LEEALAEKERTIERLKEQRDRDEREK----------QEEIDNYKKDLKDLKEKVSLLQGD 667
            L +  +  E  ++  +E    + R+K          ++E +++++ L++ +E    L+  
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358

Query: 668  LSEKEASLLDLKE-----------------------------HASSLAS------SGLKK 692
            ++   A + D+K+                             H   +A+      +  + 
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRL 1418

Query: 693  DSRLKTLEIALEQKKEECLKMESQLKK-----AHEAALEARASPEMSDRIQHLERE---- 743
               L  L + L+ +++    +E + KK     A E  + A+ + E  DR +   RE    
Sbjct: 1419 QQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEE-RDRAEAEAREKETK 1477

Query: 744  ---ITRYKDESSKAQAEVDRLLE----ILKEVENEKNDKDKKIAELERQVKDQNKKVANL 796
               + R  +E+ + +AE++RL +     ++++ + K+D  K + ELE+  +   ++V  +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537

Query: 797  KHKEQVEKKKSAQMLEEAR-RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 855
            K + + E +   Q  E+A+ R E NL     Q +  L+ +D++ EE ++ L   V+   E
Sbjct: 1538 KTQLE-ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVR---E 1593

Query: 856  REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915
             E  L  E   R+ A       + A +K++ +L+ ++A + S  ++  E    L  L+A+
Sbjct: 1594 MEAELEDERKQRSMA-------VAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646

Query: 916  RRKHLEEVLEMK--QEALLAAISEKDANIALLELSSSKKKTQEEVAALKR-------EKD 966
             +  + E+ + +  +E +LA   E +  +  +E  +   + QEE+AA +R       E+D
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSME--AEMIQLQEELAAAERAKRQAQQERD 1704

Query: 967  RLVQQL-------------KQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 1013
             L  ++             K++ + R+  + +  E++        Q N +   D++ +  
Sbjct: 1705 ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE--------QGNTELINDRLKKAN 1756

Query: 1014 LELDQNRSKLKLYIGH 1029
            L++DQ  + L L   H
Sbjct: 1757 LQIDQINTDLNLERSH 1772



 Score =  145 bits (366), Expect = 2e-34
 Identities = 192/921 (20%), Positives = 396/921 (42%), Gaps = 172/921 (18%)

Query: 309  IKKLLEML-QSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR 367
            +K LL++  Q + + AK  E    R ++LA AE  +  +E+L  Q   E   L+E++   
Sbjct: 834  VKPLLQVSRQEEEMMAKEEELVKVREKQLA-AENRLTEMETLQSQLMAEKLQLQEQLQAE 892

Query: 368  FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQME 427
             E   ++ + +A  T      +K   +E    DLE  +              EEE ++ +
Sbjct: 893  TELCAEAEELRARLT------AKKQELEEICHDLEARV--------------EEEEERCQ 932

Query: 428  VYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQE---LSRKDTELLA 484
              ++  K M+  +++L+E+L  +E+  ++L+ +    +A++ ++++E   L  ++ +L  
Sbjct: 933  HLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAK 992

Query: 485  LQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQ 544
             +  LE    +F+ +    E   +SL   + +   + T+++  RLR EEK+    +KT++
Sbjct: 993  EKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE-RLRREEKQRQELEKTRR 1051

Query: 545  -----IQDMAEEKGTQAGEIHDLKDMLDVKE---------------------RKVNVLQK 578
                   D++++      +I +LK  L  KE                     +K+  L+ 
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111

Query: 579  KIENLQEQLRDK-------EKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 631
            +I  LQE L  +       EKQ   L E +++L+ +  +T  +    +E  +++E+ +  
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171

Query: 632  LKEQRDRDEREKQEEIDNYKKDLKDLKEK----VSLLQGDLSEKEASLLDLKEHASSLAS 687
            LK       +  +EE   ++  ++++++K    V  L   L + +    +L++   +L +
Sbjct: 1172 LK-------KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLEN 1224

Query: 688  SGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRY 747
               +  + +K L       + +  K+E+QL+             E+  +    ER  T  
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQ-------------ELQVKFNEGERVRTEL 1271

Query: 748  KDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKD-------QNKKVANLKHK- 799
             D+ +K Q E+D +  +L + +++ +   K  + LE Q++D       +N++  +L  K 
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331

Query: 800  EQVEKKKSA--QMLEEARRREDNLNDS----SQQLQDSLRKKDDRI------EELEEALR 847
            +QVE +K++  + LEE    + NL         Q+ D  +K +D +      EE++  L+
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391

Query: 848  ESVQITAER--EMVLAQE--ESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA 903
            + ++  ++R  E V A +  E  +T  ++++++LL+ ++  +Q   +++ K     Q LA
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLA 1451

Query: 904  EKETHLTNLRAERRKHLEEVLEMKQEALLAA----------------------------I 935
            E++T       ER +   E  E + +AL  A                             
Sbjct: 1452 EEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMS 1511

Query: 936  SEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL------MADNYED 989
            S+ D   ++ EL  SK+  +++V  +K + + L  +L+     +++L      M   +E 
Sbjct: 1512 SKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFER 1571

Query: 990  DHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSK--------------LKLYIGHLTTLCH 1035
            D       ++   K    Q+ +   EL+  R +              LK    H+ +   
Sbjct: 1572 DLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK 1631

Query: 1036 DRDPLI-----LRGLTPPASYNLDDDQAAWENELQKMTRG------------QLQDELEK 1078
            +RD  I     L+         LDD +A+ E  L +                QLQ+EL  
Sbjct: 1632 NRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAA 1691

Query: 1079 GERDNAELQEFANAILQQIAD 1099
             ER   + Q+  + +  +IA+
Sbjct: 1692 AERAKRQAQQERDELADEIAN 1712



 Score =  142 bits (359), Expect = 1e-33
 Identities = 213/1088 (19%), Positives = 461/1088 (42%), Gaps = 169/1088 (15%)

Query: 146  ARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEA 205
            A +N + +++T   +++ E   L++ ++  E++L +    ++   + + ++   +  D  
Sbjct: 863  AAENRLTEMETLQSQLMAEKLQLQEQLQA-ETELCAEAEELRARLTAKKQELEEICHDLE 921

Query: 206  SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEE 265
            +++   +E+ + +Q E + MQ  IQ L+++L  +    Q  Q +    T E  + +L EE
Sbjct: 922  ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKV--TTEAKLKKLEEE 979

Query: 266  NFQRLHAEHERQAKELFLLRKTLEEMELRI---ETQKQTLNARDESIKKLLEMLQSKGLS 322
                L  ++ + AKE  LL   + E    +   E + ++L       + ++  L+ +   
Sbjct: 980  QII-LEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRR 1038

Query: 323  AKATEEDHERTRR------------LAEAEMHVHHLESLLEQKEKENSMLREEMHRRFEN 370
             +   ++ E+TRR            +AE +  +  L+  L +KE+E   L+  + R  E 
Sbjct: 1039 EEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE---LQAALARVEEE 1095

Query: 371  APDSAKTKALQTVIEMKDSKISSMERGL--------------RDLEEEIQMLKSNGALST 416
            A  + K  AL+ + E+ +S+IS ++  L              RDL EE++ LK+      
Sbjct: 1096 A--AQKNMALKKIREL-ESQISELQEDLESERASRNKAEKQKRDLGEELEALKTE---LE 1149

Query: 417  EEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELS 476
            +  +    Q E+     + +    + L+EE  + EAQ +E+++K +    E+ +  ++  
Sbjct: 1150 DTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTK 1209

Query: 477  RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 536
            R    L   +   +TL N+  +    ++VL +     E +   ++ ++  L+++  E E 
Sbjct: 1210 RVKANL---EKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266

Query: 537  MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS 596
            +  +   ++  +  E     G +           +  + L+ ++++ QE L+++ +Q  S
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLS 1326

Query: 597  LKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKD 656
            L  ++K ++ +  +    L   EEA    E+ I  L  Q   D ++K E+     +  ++
Sbjct: 1327 LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQV-ADMKKKMEDSVGCLETAEE 1385

Query: 657  LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQ 716
            +K K   LQ DL        +       L  +  +    L  L + L+ +++    +E +
Sbjct: 1386 VKRK---LQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442

Query: 717  LKK-----AHEAALEARASPEMSDRIQHLERE-------ITRYKDESSKAQAEVDRLLEI 764
             KK     A E  + A+ + E  DR +   RE       + R  +E+ + +AE++RL + 
Sbjct: 1443 QKKFDQLLAEEKTISAKYAEER-DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQ 1501

Query: 765  ----LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR-ED 819
                ++++ + K+D  K + ELE+  +   ++V  +K + + E +   Q  E+A+ R E 
Sbjct: 1502 FRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE-ELEDELQATEDAKLRLEV 1560

Query: 820  NLNDSSQQLQDSLRKKDDRIEELEEAL----------------RESVQITAEREMVL--- 860
            NL     Q +  L+ +D++ EE ++ L                + S+ + A +++ +   
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLK 1620

Query: 861  ---AQEESARTNAEKQV------------------------EELLMAMEKVKQELESMKA 893
               A  +SA  N ++ +                        EE+L   ++ +++L+SM+A
Sbjct: 1621 DLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA 1680

Query: 894  KLSSTQQSLAEKETHLTNLRAERRKHLEEV----------LEMKQ--EALLAAISE---- 937
            ++   Q+ LA  E      + ER +  +E+          LE K+  EA +A + E    
Sbjct: 1681 EMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEE 1740

Query: 938  ------------KDANIALLELS-------SSKKKTQEEVAALKREKDRL---VQQLKQQ 975
                        K AN+ + +++       S  +K +     L+R+   L   +Q+++  
Sbjct: 1741 EQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGT 1800

Query: 976  TQNRMKLMADNYE----------DDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKL 1025
             +++ K      E          D+  K   +     + +  ++   LL++D  R   + 
Sbjct: 1801 VKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQ 1860

Query: 1026 YIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAE 1085
            Y         D+    L+ L        ++ Q A  N  ++  + +L+D  E  +  N E
Sbjct: 1861 YKDQA-----DKASTRLKQLKRQLEEAEEEAQRA--NASRRKLQRELEDATETADAMNRE 1913

Query: 1086 LQEFANAI 1093
            +    N +
Sbjct: 1914 VSSLKNKL 1921



 Score =  116 bits (290), Expect = 1e-25
 Identities = 157/728 (21%), Positives = 316/728 (43%), Gaps = 77/728 (10%)

Query: 426  MEVYRSHSKFMKNKVEQLK--EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
            ++V R   + M  + E +K  E+  + E +  E++   + L AE  Q++++L + +TEL 
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQL-QAETELC 896

Query: 484  ALQTKLETLTNQFSDSKQHIEVLKESLTAK----EQRAAILQTEVDALRLRLEEKETMLN 539
            A   + E L  + +  KQ +E +   L A+    E+R   LQ E   ++  ++E E  L 
Sbjct: 897  A---EAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953

Query: 540  KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 599
            ++    Q +  EK T   ++  L++   + E +   L K+ + L++++ +    ++  +E
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 600  RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 659
            + KSL       +  +T LEE L          +E++ R E EK       + D  DL +
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLR---------REEKQRQELEKTRR--KLEGDSTDLSD 1062

Query: 660  KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
            +++ LQ  ++E +  L   KE     A + +++++  K +  AL++ +E    +ESQ+ +
Sbjct: 1063 QIAELQAQIAELKMQLAK-KEEELQAALARVEEEAAQKNM--ALKKIRE----LESQISE 1115

Query: 720  AHEAALEARASPEMSDRIQH-LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
              E     RAS   +++ +  L  E+   K E            E+  + E E N   K 
Sbjct: 1116 LQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK- 1174

Query: 779  IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDR 838
               LE + K    ++  ++ K     ++ A+ LE+ +R + NL  + Q L++   +  + 
Sbjct: 1175 --TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232

Query: 839  IEEL------EEALRESVQITAEREMVLAQE-ESARTNAEKQVEELLMAME--------- 882
            ++ L       E  R+ V+   +   V   E E  RT    +V +L + ++         
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS 1292

Query: 883  -----KVKQELESMKAKLSSTQQSLAEKETHLTNLRA------ERRKHLEEVLEMKQEAL 931
                 K+ ++  +++++L  TQ+ L E+     +L        + +    E LE ++EA 
Sbjct: 1293 DSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA- 1351

Query: 932  LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD- 990
                 EK       +++  KKK ++ V  L+       +++K++ Q  ++ ++  +E+  
Sbjct: 1352 -KHNLEKQIATLHAQVADMKKKMEDSVGCLE-----TAEEVKRKLQKDLEGLSQRHEEKV 1405

Query: 991  -HFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPA 1049
              +      +T  +   D +   L++LD  R        +L       D L+    T  A
Sbjct: 1406 AAYDKLEKTKTRLQQELDDL---LVDLDHQRQS----ACNLEKKQKKFDQLLAEEKTISA 1458

Query: 1050 SYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFANAILQQIAD--HCPDILEQ 1107
             Y  + D+A  E   ++     L   LE+     AEL+        ++ D     D + +
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGK 1518

Query: 1108 VVNALEES 1115
             V+ LE+S
Sbjct: 1519 SVHELEKS 1526



 Score =  105 bits (262), Expect = 2e-22
 Identities = 144/654 (22%), Positives = 281/654 (42%), Gaps = 96/654 (14%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP--ELKKER-- 198
            L Q  +   + L T+LK+V  E +  R+ +E +E    +    I T  +   ++KK+   
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375

Query: 199  ---ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTG 255
                L   E  K  + K+   + Q   + +    +  + + R+Q++L+ L   D   +  
Sbjct: 1376 SVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLV-DLDHQRQ 1434

Query: 256  EPCVAELTEENFQRLHAEH-------------------ERQAKELFLLRKTLEEMELRIE 296
              C  E  ++ F +L AE                    E++ K L L R   E ME + E
Sbjct: 1435 SACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAE 1494

Query: 297  TQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKE 356
             ++     R E    + +++ SK    K+  E  +  R L   E  V  +++ LE+ E E
Sbjct: 1495 LERLNKQFRTE----MEDLMSSKDDVGKSVHELEKSKRAL---EQQVEEMKTQLEELEDE 1547

Query: 357  NSMLREEMHRRFEN--APDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGAL 414
                 +   R   N  A  +   + LQ   E  + K   + R +R++E E++  +   ++
Sbjct: 1548 LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSM 1607

Query: 415  STEER---EEEMKQMEVY---------------RSHSKFMKNKVEQLKEELSSKE---AQ 453
            +   R   E ++K +E +               R     MK+ + +L +  +S+E   AQ
Sbjct: 1608 AVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQ 1667

Query: 454  WEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK 513
             +E +KK   ++AE+ Q+++EL+  +      Q + + L ++ ++S       K +L  +
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSG-----KGALALE 1722

Query: 514  EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
            E+R   L+  +  L   LEE++      T+ I D  ++   Q  +I+      D+   + 
Sbjct: 1723 EKRR--LEARIAQLEEELEEEQ----GNTELINDRLKKANLQIDQIN-----TDLNLERS 1771

Query: 574  NVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLK 633
            +   +K EN ++QL   E+Q   LK +++ ++       T  +  + ++   E  I +L+
Sbjct: 1772 HA--QKNENARQQL---ERQNKELKVKLQEMEG------TVKSKYKASITALEAKIAQLE 1820

Query: 634  EQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKD 693
            EQ D + +E+Q      ++  K LK+   LLQ D         D + +A        K  
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKD--VLLQVD---------DERRNAEQYKDQADKAS 1869

Query: 694  SRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE-MSDRIQHLEREITR 746
            +RLK L+  LE+ +EE  +  +  +K      +A  + + M+  +  L+ ++ R
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  146 bits (368), Expect = 1e-34
 Identities = 204/958 (21%), Positives = 417/958 (43%), Gaps = 121/958 (12%)

Query: 156  TQLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKERALRKDEASK 207
            T+LKE L +++  RK++E K   L    N ++             E + ++ ++     +
Sbjct: 857  TRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLE 916

Query: 208  ITIWKEQYRVVQEENQHMQMTI--QALQDEL-RIQRDLNQ----LFQQDSSSRTGEPCVA 260
              + +   R+  EE  + ++T   + L+DE   ++RD++     L + +      E  V 
Sbjct: 917  AKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVK 976

Query: 261  ELTEE--NFQRLHAEHERQAKEL-FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQ 317
             LTEE      + A+  ++ K L    ++ L++++   E +  TL      +++ ++ L+
Sbjct: 977  NLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAE-EDKVNTLTKAKVKLEQQVDDLE 1035

Query: 318  SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR-FENAPDSAK 376
                  K    D ER +R  E ++ +   ES+++  E +   L E + ++ FE    +A+
Sbjct: 1036 GSLEQEKKVRMDLERAKRKLEGDLKLTQ-ESIMD-LENDKQQLDERLKKKDFELNALNAR 1093

Query: 377  TKALQTVIEMKDSKISSMERGLRDLEEE----------IQMLKSNGALSTEEREEEMK-- 424
             +  Q +      K+  ++  + +LEEE          ++ L+S+ +   EE  E ++  
Sbjct: 1094 IEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEA 1153

Query: 425  ------QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ-------V 471
                  Q+E+ +      +     L+E     EA    L+KK A   AE+G+       V
Sbjct: 1154 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1213

Query: 472  KQELSRKDTE--------------LLALQTKLE----TLTNQFSDSKQHIEVLKESLTAK 513
            KQ+L ++ +E              ++  +  LE    TL +Q ++ +   E  + S+   
Sbjct: 1214 KQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDL 1273

Query: 514  EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
              + A LQTE   L  +L+EKE ++++ T+        K T   ++ DLK  L+ + +  
Sbjct: 1274 TSQRAKLQTENGELSRQLDEKEALISQLTR-------GKLTYTQQLEDLKRQLEEEVKAK 1326

Query: 574  NVLQKKIEN-------LQEQLRDKEKQMSSLKERVKSLQADTTNTDT-----ALTTLEEA 621
            N L   +++       L+EQ  ++ +  + L+  +    ++     T     A+   EE 
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1386

Query: 622  LAEKERTIERLKEQRDRDE--REKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
               K++  +RL+E  +  E    K   ++  K  L++  E + ++  + S   A+ LD K
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDL-MVDVERSNAAAAALDKK 1445

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-SQLKKAHEAALEARASPEMSDRIQ 738
            +       +  K+       E+   QK+   L  E  +LK A+E +LE   + +  ++  
Sbjct: 1446 QRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENK-- 1503

Query: 739  HLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV--ANL 796
            +L+ EI+   ++   +   +  L ++ K++E EK +    + E E  ++ +  K+  A L
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563

Query: 797  KH---KEQVEKK--KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQ 851
            +    K ++E+K  +  + +E+A+R    + DS   LQ SL   D       EALR   +
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDS---LQTSL---DAETRSRNEALRVKKK 1617

Query: 852  ITA---EREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA--EKE 906
            +     E E+ L+        A+KQV+ L   ++  + +L+         ++++A  E+ 
Sbjct: 1618 MEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR 1677

Query: 907  THLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALL-----ELSSSKKKTQEEVAAL 961
             +L     E  + + E  E  ++     + E    + LL      L + KKK   +++ L
Sbjct: 1678 NNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQL 1737

Query: 962  KREKDRLVQQLKQQTQNRMK------LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 1013
            + E +  VQ+ +   +   K      +MA+  + +   S+H  +   K + +Q I+ L
Sbjct: 1738 QTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM--KKNMEQTIKDL 1793



 Score =  131 bits (329), Expect = 4e-30
 Identities = 202/957 (21%), Positives = 405/957 (42%), Gaps = 159/957 (16%)

Query: 142  SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
            +L++A    + DLQ +  +V   N L +  V++ E ++     S++      +  ERA R
Sbjct: 998  ALQEAHQQALDDLQAEEDKV---NTLTKAKVKL-EQQVDDLEGSLEQEKKVRMDLERAKR 1053

Query: 202  KDEASKITIWKEQYRVVQEENQHMQMTIQALQDEL-----RIQRDLNQLFQQDSSSRTGE 256
            K E   + + +E    ++ + Q +   ++    EL     RI+ +     Q     +  +
Sbjct: 1054 KLEGD-LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112

Query: 257  PCVAELTEENFQRLHAEHERQAKELFL---LRKTLEEMELRIE-------TQKQTLNARD 306
              + EL EE    L AE   +AK   L   L + LEE+  R+E        Q +    R+
Sbjct: 1113 ARIEELEEE----LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKRE 1168

Query: 307  ESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEM--HVHHLESLLEQKEKENSMLREEM 364
               +K+   L+   L  +AT     +    + AE+   + +L+ + ++ EKE S  + E+
Sbjct: 1169 AEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL 1228

Query: 365  HRRFENAPDSAKTKA--------LQTVIEMKDSKISSMERGLRDLEEEIQMLKS-NGALS 415
                 N     K KA        L+  +    SK    +R + DL  +   L++ NG LS
Sbjct: 1229 DDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288

Query: 416  TEEREEEMKQMEVYR---SHSKFMKNKVEQLKEELSSKEA-----------------QWE 455
             +  E+E    ++ R   ++++ +++   QL+EE+ +K A                 Q+E
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYE 1348

Query: 456  ELKKKAAGLQAEIGQVKQELS----RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLT 511
            E  +  A LQ  + +   E++    + +T+ +    +LE    + +   Q  E   E++ 
Sbjct: 1349 EETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVN 1408

Query: 512  AK----EQRAAILQTEVDALRLRLEEKETM---LNKKTK------------------QIQ 546
            AK    E+    LQ E++ L + +E        L+KK +                  +++
Sbjct: 1409 AKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELE 1468

Query: 547  DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS-------LKE 599
               +E  + + E+  LK+  +     +   +++ +NLQE++ D  +Q+ S       L++
Sbjct: 1469 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEK 1528

Query: 600  RVKSLQADTTNTDTALTTLEEALAEKERTIER-------LKEQRDRDEREKQEEIDNYKK 652
              K L+A+     +AL   E +L  +E  I R       +K + +R   EK EE++  K+
Sbjct: 1529 VRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKR 1588

Query: 653  DLKDLKEKVSL------------------LQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
            +   + + +                    ++GDL+E E  L     HA+ +A+   K+  
Sbjct: 1589 NHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL----SHANRMAAEAQKQVK 1644

Query: 695  RLKTLEIALEQKKEECLKMESQLKKAHEAALEARAS------PEMSDRIQHLEREITRYK 748
             L++L    + + ++ ++    LK+ + A +E R +       E+   ++  ER     +
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKE-NIAIVERRNNLLQAELEELRAVVEQTERSRKLAE 1703

Query: 749  DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 808
             E  +    V  L      + N+K   D  +++L+ +V++  ++  N + K +     +A
Sbjct: 1704 QELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAA 1763

Query: 809  QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESART 868
             M EE ++ +    D+S  L+   +  +  I++L+  L E+ QI             A  
Sbjct: 1764 MMAEELKKEQ----DTSAHLERMKKNMEQTIKDLQHRLDEAEQI-------------ALK 1806

Query: 869  NAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE---THLTNLRAERRKHLEEV-- 923
              +KQ+++L   + +++ ELE+ + + + + + + + E     LT    E RK+L  +  
Sbjct: 1807 GGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQD 1866

Query: 924  ------LEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 974
                  L++K     A  +E+ AN  L    S  +K Q E+   +   D    Q+ +
Sbjct: 1867 LVDKLQLKVKAYKRQAEEAEEQANTNL----SKFRKVQHELDEAEERADIAESQVNK 1919



 Score =  122 bits (305), Expect = 2e-27
 Identities = 168/774 (21%), Positives = 335/774 (43%), Gaps = 126/774 (16%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ +  ++EE   LK     S   R+E  ++M         ++ +V+  ++ L+ 
Sbjct: 841  KSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLAD 900

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A++ ++ + L  ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 901  AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELT 960

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   +   + ++ K TK      E+K  Q      L D L  +
Sbjct: 961  LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK------EKKALQEAHQQALDD-LQAE 1013

Query: 570  ERKVNVLQK-------KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
            E KVN L K       ++++L+  L  ++K    L+   + L+ D   T  ++  LE   
Sbjct: 1014 EDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN-- 1071

Query: 623  AEKERTIERLKEQ---------RDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEA 673
             +K++  ERLK++         R  DE+    ++   +K LK+L+ ++  L+ +L  +  
Sbjct: 1072 -DKQQLDERLKKKDFELNALNARIEDEQALGSQL---QKKLKELQARIEELEEELEAERT 1127

Query: 674  SLLDLKEHASSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEA 723
            +   +++  S L+      S  L++     +++I + +K+E E  KM   L++A   HEA
Sbjct: 1128 ARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEA 1187

Query: 724  AL------EARASPEMSDRIQHLEREITRYKDESSKAQAEVD--------------RLLE 763
                     A +  E+ ++I +L+R   + + E S+ + E+D               L +
Sbjct: 1188 TAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEK 1247

Query: 764  ILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKS----------- 807
            + + +E++ N+   K  E +R V D   + A L+ +      Q+++K++           
Sbjct: 1248 MCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLT 1307

Query: 808  -AQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA 866
              Q LE+ +R+ +    +   L  +L+      + L E   E  +  AE + VL++  S 
Sbjct: 1308 YTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSE 1367

Query: 867  --------RTNAEKQVEELLMAMEKVKQEL-------ESMKAKLSSTQQSLAEKETHLTN 911
                     T+A ++ EEL  A +K+ Q L       E++ AK SS +++    +  + +
Sbjct: 1368 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIED 1427

Query: 912  LR--AERRKHLEEVLEMKQ---EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKD 966
            L    ER       L+ KQ   + +LA   +K       E  S  + +Q+E  +L  E  
Sbjct: 1428 LMVDVERSNAAAAALDKKQRNFDKILAEWKQK-----YEESQSELESSQKEARSLSTELF 1482

Query: 967  RLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLY 1026
            +L    ++  ++   L     E+ + +   S+ T    S  + I    EL++ R +L+  
Sbjct: 1483 KLKNAYEESLEH---LETFKRENKNLQEEISDLTEQLGSSGKTIH---ELEKVRKQLEAE 1536

Query: 1027 IGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGE 1080
               L +                    L++ +A+ E+E  K+ R QL+    K E
Sbjct: 1537 KMELQSA-------------------LEEAEASLEHEEGKILRAQLEFNQIKAE 1571



 Score =  119 bits (298), Expect = 2e-26
 Identities = 155/742 (20%), Positives = 329/742 (44%), Gaps = 81/742 (10%)

Query: 352  QKEKENSMLREEMHRRFENAPDS-AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
            ++EKE + ++EE  R  E    S A+ K L+        K+ S+ +   DL+ ++Q  + 
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELE-------EKMVSLLQEKNDLQLQVQAEQD 896

Query: 411  NGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ 470
            N A + E  ++ +K      +  K M  ++E  +E  +   A+  +L+ + + L+ +I  
Sbjct: 897  NLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDD 956

Query: 471  VKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVL---KESLTAKEQRAAI-LQTEVDA 526
            ++  L++ + E  A + K++ LT + +   + I  L   K++L    Q+A   LQ E D 
Sbjct: 957  LELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDK 1016

Query: 527  L------RLRLEEK----ETMLNKKTKQIQDMAEEKGTQAGEI--------------HDL 562
            +      +++LE++    E  L ++ K   D+   K    G++                L
Sbjct: 1017 VNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQL 1076

Query: 563  KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
             + L  K+ ++N L  +IE+ Q      +K++  L+ R++ L+ +     TA   +E+  
Sbjct: 1077 DERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLR 1136

Query: 623  AEKERTIERLKEQRDRDEREKQEEID-NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEH 681
            ++  R +E + E+ +        +I+ N K++ +  K +  L +  L  +  +    K+H
Sbjct: 1137 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1196

Query: 682  ASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLE 741
            A S+A  G + D+ L+ ++  LE++K E       +    E  ++A+A+ E   R   LE
Sbjct: 1197 ADSVAELGEQIDN-LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRT--LE 1253

Query: 742  REITRYKDESSKAQAEVDRLLEILKEVENEK-------NDKDKKIAELERQVKDQNKKVA 794
             ++  ++ ++ + Q  V+ L     +++ E        ++K+  I++L R      +++ 
Sbjct: 1254 DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLE 1313

Query: 795  NLKHK--EQVEKKKS-AQMLEEARRREDNLNDSSQQ-------LQDSLRKKDD------- 837
            +LK +  E+V+ K + A  L+ AR   D L +  ++       LQ  L K +        
Sbjct: 1314 DLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRT 1373

Query: 838  --------RIEELEEALRESVQITAEREMVLAQEESARTNAEK-------QVEELLMAME 882
                    R EELEEA ++  Q   E E  +    +  ++ EK       ++E+L++ +E
Sbjct: 1374 KYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433

Query: 883  KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
            +      ++  K  +  + LAE +      ++E     +E   +  E      + +++  
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493

Query: 943  ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
             L       K  QEE++ L  +     + + +  + R +L A+  E             H
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEH 1553

Query: 1003 KPSPDQIIQPLLELDQNRSKLK 1024
            +    +I++  LE +Q +++++
Sbjct: 1554 EEG--KILRAQLEFNQIKAEIE 1573



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 97/436 (22%), Positives = 195/436 (44%), Gaps = 55/436 (12%)

Query: 151  IMDLQTQLK---EVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASK 207
            I DL  QL    + + E + +RK +E ++ +L S++   +     E   E  + + +   
Sbjct: 1509 ISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHE---EGKILRAQLEF 1565

Query: 208  ITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRT----------GEP 257
              I  E  R + E+++ M+   QA ++ LR+   L      ++ SR           G+ 
Sbjct: 1566 NQIKAEIERKLAEKDEEME---QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDL 1622

Query: 258  CVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESI---KKLLE 314
               E+   +  R+ AE ++Q K L   +  L++ +++++   +  +   E+I   ++   
Sbjct: 1623 NEMEIQLSHANRMAAEAQKQVKSL---QSLLKDTQIQLDDAVRANDDLKENIAIVERRNN 1679

Query: 315  MLQSKGLSAKATEEDHERTRRLAEAEM-------HVHHLE--SLLEQKEKENSMLR---- 361
            +LQ++    +A  E  ER+R+LAE E+        + H +  SL+ QK+K ++ L     
Sbjct: 1680 LLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT 1739

Query: 362  --EEMHRRFENAPDSAK---TKALQTVIEMKDSKISS--MERGLRDLEEEIQMLKSNGAL 414
              EE  +   NA + AK   T A     E+K  + +S  +ER  +++E+ I+ L      
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDL------ 1793

Query: 415  STEEREEEMKQMEVYRSHSKFMK--NKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
              + R +E +Q+ +     +  K   +V +L+ EL +++ +  E  K     +  I ++ 
Sbjct: 1794 --QHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1851

Query: 473  QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
             +       LL LQ  ++ L  +    K+  E  +E       +   +Q E+D    R +
Sbjct: 1852 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERAD 1911

Query: 533  EKETMLNKKTKQIQDM 548
              E+ +NK   + +D+
Sbjct: 1912 IAESQVNKLRAKSRDI 1927



 Score = 34.3 bits (77), Expect = 0.68
 Identities = 53/244 (21%), Positives = 100/244 (40%), Gaps = 47/244 (19%)

Query: 873  QVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALL 932
            +++ LL + E+ K E+ SMK + +  +++L + E         RRK LE       E ++
Sbjct: 835  KIKPLLKSAEREK-EMASMKEEFTRLKEALEKSEA--------RRKELE-------EKMV 878

Query: 933  AAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHF 992
            + + EK+      +L    +  Q+ +A  +   D+L++  K Q + ++K M +  ED+  
Sbjct: 879  SLLQEKN------DLQLQVQAEQDNLADAEERCDQLIKN-KIQLEAKVKEMNERLEDEEE 931

Query: 993  KSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYN 1052
             ++       K     +     EL ++   L+L +  +    H          T     N
Sbjct: 932  MNAELTAKKRK-----LEDECSELKRDIDDLELTLAKVEKEKH---------ATENKVKN 977

Query: 1053 LDDDQAAWENELQKMTR---------GQLQDELEKGERDNAELQEFANAILQQIADHCPD 1103
            L ++ A  +  + K+T+          Q  D+L+  E D       A   L+Q  D    
Sbjct: 978  LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ-AEEDKVNTLTKAKVKLEQQVDDLEG 1036

Query: 1104 ILEQ 1107
             LEQ
Sbjct: 1037 SLEQ 1040


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score =  144 bits (363), Expect = 5e-34
 Identities = 192/954 (20%), Positives = 416/954 (43%), Gaps = 115/954 (12%)

Query: 157  QLKEVLRENDLLRKDVEVKESKLSSSMNSIK--------TFWSPELKKERALRKDEASKI 208
            ++KE L +++  RK++E K   L    N ++             E + ++ ++     + 
Sbjct: 860  RIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEA 919

Query: 209  TIWKEQYRVVQEENQHMQMTI--QALQDEL-RIQRDLNQ----LFQQDSSSRTGEPCVAE 261
             + +   R+  EE  + ++T   + L+DE   +++D++     L + +      E  V  
Sbjct: 920  KVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 979

Query: 262  LTEE--NFQRLHAEHERQAKEL-FLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
            LTEE      + A+  ++ K L    ++ L+++++  E +  +L+     +++ ++ L+ 
Sbjct: 980  LTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVE-EDKVNSLSKSKVKLEQQVDDLEG 1038

Query: 319  KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR-FENAPDSAKT 377
                 K    D ER +R  E ++ +   ES+++  E +   L E++ ++ F+    ++K 
Sbjct: 1039 SLEQEKKVRMDLERAKRKLEGDLKLTQ-ESIMD-LENDKLQLEEKLKKKEFDINQQNSKI 1096

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEE----------IQMLKSNGALSTEEREEEMK--- 424
            +  Q +      K+   +  + +LEEE          ++ L+S+ +   EE  E ++   
Sbjct: 1097 EDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1156

Query: 425  -----QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ-------VK 472
                 Q+E+ +      +     L+E     EA    L+KK A   AE+G+       VK
Sbjct: 1157 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1216

Query: 473  QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
            Q+L ++ +E      KLE       D   ++E + ++    E+ +  L+ + +  R++LE
Sbjct: 1217 QKLEKEKSEF-----KLE-----LDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE 1266

Query: 533  EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEK 592
            E +  LN  T Q   +  E G  A ++ + + ++    R      +++E+L+ QL ++ K
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326

Query: 593  QMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL-------KEQRDRDEREKQE 645
              ++L   ++S + D            EA AE +R + +        + + + D  ++ E
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386

Query: 646  EIDNYKKD----LKDLKEKVSLLQGDLSEKEASLLDLK----------EHASSLASSGLK 691
            E++  KK     L+D +E V  +    S  E +   L+          E +++ A++  K
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446

Query: 692  KDSRLKTLEIALEQKKEEC-LKMESQLKKAHEAALEA-RASPEMSDRIQHLE-------- 741
            K      +    +QK EE   ++ES  K+A   + E  +      + ++HLE        
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1506

Query: 742  --REITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV--ANLK 797
               EI+   ++  +    V  L ++ K++E EK +    + E E  ++ +  K+  A L+
Sbjct: 1507 LQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLE 1566

Query: 798  H---KEQVEKK--KSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQI 852
                K ++E+K  +  + +E+A+R    + DS Q   D+  +  + +  +++ +   +  
Sbjct: 1567 FNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLN- 1625

Query: 853  TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLA--EKETHLT 910
              E E+ L+        A+KQV+ L   ++  + +L+         ++++A  E+  +L 
Sbjct: 1626 --EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683

Query: 911  NLRAERRKHLEEVLEMKQEALLAAISEKDANIALL-----ELSSSKKKTQEEVAALKREK 965
                E  + + E  E  ++     + E    + LL      L + KKK + ++  L+ E 
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEV 1743

Query: 966  DRLVQQLKQQTQNRMK------LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL 1013
            +  VQ+ +   +   K      +MA+  + +   S+H  +   K + +Q I+ L
Sbjct: 1744 EEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM--KKNMEQTIKDL 1795



 Score =  136 bits (342), Expect = 1e-31
 Identities = 196/941 (20%), Positives = 401/941 (42%), Gaps = 118/941 (12%)

Query: 142  SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
            +L++A    + DLQ +  +V   N L +  V++ E ++     S++      +  ERA R
Sbjct: 1000 ALQEAHQQALDDLQVEEDKV---NSLSKSKVKL-EQQVDDLEGSLEQEKKVRMDLERAKR 1055

Query: 202  KDEAS-KITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
            K E   K+T    Q  ++  EN  +Q+  +  + E     D+NQ   Q+S          
Sbjct: 1056 KLEGDLKLT----QESIMDLENDKLQLEEKLKKKEF----DINQ---QNS---------- 1094

Query: 261  ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
            ++ +E    L             L+K L+E + RIE  ++ L A + + +  +E L+S  
Sbjct: 1095 KIEDEQVLALQ------------LQKKLKENQARIEELEEELEA-ERTARAKVEKLRSD- 1140

Query: 321  LSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLR---EEMHRRFENAPDSAKT 377
                 + E  E + RL EA         + +++E E   +R   EE   + E    + + 
Sbjct: 1141 ----LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRK 1196

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMK 437
            K   +V E+ + +I +++R  + LE+E    K      T   E+ +K        S+ ++
Sbjct: 1197 KHADSVAELGE-QIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLE 1255

Query: 438  NKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFS 497
            ++  + + +L   +    +   + A LQ E G++ ++L  K+  +  L     + T Q  
Sbjct: 1256 DQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQME 1315

Query: 498  DSKQHIEVLKESLTAKEQRAAILQT---EVDALRLRLEEK-------ETMLNKKTKQIQD 547
            D K+ +E   E   AK   A  LQ+   + D LR + EE+       + +L+K   ++  
Sbjct: 1316 DLKRQLE---EEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQ 1372

Query: 548  MAEEKGTQAGEIHDLKDMLDVKERKVNVLQ---KKIENLQEQLRDKEKQMSSLKERVKSL 604
               +  T A  I   +++ + K++    LQ   + +E +  +    EK    L+  ++ L
Sbjct: 1373 WRTKYETDA--IQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDL 1430

Query: 605  QADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLL 664
              D   ++ A   L++    K+R  +++  +  +   E Q E+++ +K+ + L  ++  L
Sbjct: 1431 MVDVERSNAAAAALDK----KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKL 1486

Query: 665  QGDLSEKEASL-------LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQL 717
            +    E    L        +L+E  S L     +    +  LE   +Q + E L+++S L
Sbjct: 1487 KNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSAL 1546

Query: 718  KKA-----HEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILK-EVENE 771
            ++A     HE     RA  E +     +ER++    +E  +A+    R+++ L+  ++ E
Sbjct: 1547 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAE 1606

Query: 772  KNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDS 831
               +++ +   ++   D N+    L H  ++    +A+  ++ +  +  L D+  QL D+
Sbjct: 1607 TRSRNEVLRVKKKMEGDLNEMEIQLSHANRM----AAEAQKQVKSLQSLLKDTQIQLDDA 1662

Query: 832  LRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK------ 885
            +R  DD  E +    R +  + AE E + A  E    + +   +EL+   E+V+      
Sbjct: 1663 VRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQN 1722

Query: 886  ----QELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDAN 941
                 + + M++ L+  Q  + E      N   + +K + +   M +E       E+D +
Sbjct: 1723 TSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELK----KEQDTS 1778

Query: 942  IALLELSSSKKKT---------QEEVAALKREKDRL------VQQLKQQTQNRMKLMADN 986
              L  +  + ++T         + E  ALK  K +L      V++L+ + +   K  A++
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838

Query: 987  YEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYI 1027
             +          +  ++   D+  + LL L     KL+L +
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDK--KNLLRLQDLVDKLQLKV 1877



 Score =  125 bits (314), Expect = 2e-28
 Identities = 180/852 (21%), Positives = 354/852 (41%), Gaps = 135/852 (15%)

Query: 136  ASTVPHSLRQARDNTIMDLQTQLKEVLRENDL----LRKDVEVKESKLSSSMNSIKTFWS 191
            A++V   + + R+     ++  L+E   +++     LRK      ++L   +++++    
Sbjct: 1158 ATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV-K 1216

Query: 192  PELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRI-----QRDLNQLF 246
             +L+KE++  K E   +T   EQ    +   + +  T++   +E R+     QR LN   
Sbjct: 1217 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276

Query: 247  QQDSSSRTG-----------EPCVAELTE---------ENFQRLHAEHERQAKELF---- 282
             Q +  +T            E  +++LT          E+ +R   E E +AK       
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKR-QLEEEGKAKNALAHAL 1335

Query: 283  --------LLRKTLEE-MELRIETQKQTLNARDE-----------SIKKLLEMLQSKGLS 322
                    LLR+  EE  E + E Q+    A  E           +I++  E+ ++K   
Sbjct: 1336 QSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1395

Query: 323  AKATEEDHERTR----RLAEAEMHVHHL----ESLLEQKEKENSMLR--EEMHRRFENAP 372
            A+  ++  E       + +  E   H L    E L+   E+ N+     ++  R F+   
Sbjct: 1396 AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKIL 1455

Query: 373  DSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSH 432
               K K      E   S++ S ++  R L  E+  LK+         EE ++ +E ++  
Sbjct: 1456 AEWKQK-----YEESQSELESSQKEARSLSTELFKLKN-------AYEESLEHLETFKRE 1503

Query: 433  SKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETL 492
            +K ++ ++  L E+L        EL+K    L+ E  +++  L   +  L   + K+   
Sbjct: 1504 NKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRA 1563

Query: 493  TNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEE 551
              +F+  K  IE  L E     EQ     Q  VD+L       +T L+ +T+   ++   
Sbjct: 1564 QLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSL-------QTSLDAETRSRNEVLRV 1616

Query: 552  KGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNT 611
            K    G++++++  L    R     QK++++LQ  L+D + Q+         L+ +    
Sbjct: 1617 KKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIV 1676

Query: 612  DTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEK 671
            +     L+  L E    +E+ +  R   E+E           L +  E+V LL      +
Sbjct: 1677 ERRNNLLQAELEELRAVVEQTERSRKLAEQE-----------LIETSERVQLLH----SQ 1721

Query: 672  EASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-HEAALEARAS 730
              SL++ K+          K +S L  L+  +E+  +EC   E + KKA  +AA+ A   
Sbjct: 1722 NTSLINQKK----------KMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEEL 1771

Query: 731  PEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQN 790
             +  D   HLER     +      Q  +D   +I       K  K K++ +LE +V++  
Sbjct: 1772 KKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIAL-----KGGK-KQLQKLEARVRE-- 1823

Query: 791  KKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 850
                 L+ + + E+K++A+ ++  R+ E  + + + Q ++  +K   R+++L + L+  +
Sbjct: 1824 -----LEGELEAEQKRNAESVKGMRKSERRIKELTYQTEED-KKNLLRLQDLVDKLQ--L 1875

Query: 851  QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLT 910
            ++ A +      EE A TN  K          KV+ EL+  + +    +  + +      
Sbjct: 1876 KVKAYKRQAEEAEEQANTNLSK--------FRKVQHELDEAEERADIAESQVNKLRAKSR 1927

Query: 911  NLRAERRKHLEE 922
            ++ A+++ H EE
Sbjct: 1928 DIGAKQKMHDEE 1939



 Score =  122 bits (305), Expect = 2e-27
 Identities = 165/800 (20%), Positives = 346/800 (43%), Gaps = 105/800 (13%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ +  ++EE   +K     S   R+E  ++M         ++ +V+  ++ L+ 
Sbjct: 843  KSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLND 902

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A++ ++ + L  ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 903  AEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELT 962

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   +   + ++ K TK      E+K  Q      L D L V+
Sbjct: 963  LAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK------EKKALQEAHQQALDD-LQVE 1015

Query: 570  ERKVNVLQK-------KIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
            E KVN L K       ++++L+  L  ++K    L+   + L+ D   T  ++  LE   
Sbjct: 1016 EDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDK 1075

Query: 623  AEKERTIER----LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDL 678
             + E  +++    + +Q  + E E+   +   KK LK+ + ++  L+ +L  +  +   +
Sbjct: 1076 LQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKK-LKENQARIEELEEELEAERTARAKV 1134

Query: 679  KEHASSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEAAL--- 725
            ++  S L+      S  L++     +++I + +K+E E  KM   L++A   HEA     
Sbjct: 1135 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1194

Query: 726  ---EARASPEMSDRIQHLEREITRYKDESSKAQAEVD--------------RLLEILKEV 768
                A +  E+ ++I +L+R   + + E S+ + E+D               L ++ + +
Sbjct: 1195 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTL 1254

Query: 769  ENEKNDKDKKIAELERQVKDQNKKVANLKHK-----EQVEKKKS------------AQML 811
            E++ N+   K+ E +R + D   + A L+ +      Q+E+K++             Q +
Sbjct: 1255 EDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQM 1314

Query: 812  EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESA----- 866
            E+ +R+ +    +   L  +L+      + L E   E  +  AE + VL++  S      
Sbjct: 1315 EDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWR 1374

Query: 867  ---RTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEV 923
                T+A ++ EEL  A +K+ Q L+  +  + +     +  E     L+ E    + +V
Sbjct: 1375 TKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDV 1434

Query: 924  LEMKQEALLAAISEKDANI--ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMK 981
               +  A  AA+ +K  N    L E     +++Q E+ + ++E   L  +L +       
Sbjct: 1435 --ERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFK------- 1485

Query: 982  LMADNYED--DHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDP 1039
             + + YE+  +H ++      N +     + + L E  +N  +L+     L     + + 
Sbjct: 1486 -LKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQL-----EVEK 1539

Query: 1040 LILRGLTPPASYNLDDDQAAWENELQKMTRGQLQ-----DELEKGERDNAELQEFANAIL 1094
            L L+         L++ +A+ E+E  K+ R QL+      E+E+   +  E  E A    
Sbjct: 1540 LELQSA-------LEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNH 1592

Query: 1095 QQIADHCPDILEQVVNALEE 1114
            Q++ D     L+    +  E
Sbjct: 1593 QRVVDSLQTSLDAETRSRNE 1612


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score =  144 bits (363), Expect = 5e-34
 Identities = 188/957 (19%), Positives = 402/957 (42%), Gaps = 148/957 (15%)

Query: 195  KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDSSSR 253
            K +  L K EA +  + ++   ++QE+N  +Q+ +QA  D L   +   +QL +      
Sbjct: 862  KTKEELAKTEAKRKELEEKMVTLMQEKND-LQLQVQAEADALADAEERCDQLIKTKIQLE 920

Query: 254  TGEPCVAELTEENFQ---RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIK 310
                 V E  E+  +    L A+  +   E   L+K ++++EL +   ++  +A +  +K
Sbjct: 921  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980

Query: 311  KLLEMLQSKGLSA---------KATEEDHERT---------------RRLAEAEMHVHHL 346
             L E  +  GL           KA +E H++T               +   + E  V  L
Sbjct: 981  NLTE--EMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDL 1038

Query: 347  ESLLEQKEK----------------------------ENSMLREEMHRR-FENAPDSAKT 377
            E  LEQ++K                            +   L E++ ++ FE +    K 
Sbjct: 1039 EGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKI 1098

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY-------- 429
            +  Q +      KI  ++  + +LEEEI+  +++ A + ++R +  +++E          
Sbjct: 1099 EDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158

Query: 430  -----------RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
                       +  ++F K +   L+E     EA    L+KK A   AE+G+    L R 
Sbjct: 1159 GATSAQIEMNKKREAEFQKMR-RDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRV 1217

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
              +L   +++L+    + +D   ++E + ++    E+    L+ ++  ++ + EE++ ++
Sbjct: 1218 KQKLEKEKSELKM---EINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLI 1274

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
            N+ + Q   +  E G  + ++ +   M+    R      ++IE L+ QL ++ K  S+L 
Sbjct: 1275 NELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLA 1334

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK 658
              ++S + D           +EA AE +R + +   +  +   + + +     ++L++ K
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 659  EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK 718
            +K   L   L + E  +  +    +SL  +  +  + ++ L I +E+    C+ ++ + +
Sbjct: 1395 KK---LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQR 1451

Query: 719  KAHEAALEARASPEMSD-RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 777
               +   E +   E +   ++  ++E      E  K +   +  L+ L+ ++ E  +  +
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQ 1511

Query: 778  KIAELERQVKDQNKKVANL-KHKEQVEKKKSAQM--LEEAR-----------RREDNLND 823
            +I++L  Q+ +  K +  L K K+Q++ +KS     LEEA            R +  LN 
Sbjct: 1512 EISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQ 1571

Query: 824  SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA-------EKQVEE 876
               ++   + +KD   EEL++  R  +++    +  L  E  +R +A       E  + E
Sbjct: 1572 VKSEIDRKIAEKD---EELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNE 1628

Query: 877  LLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNL------------RAERRKHL--EE 922
            + + +    ++       L +TQ  L + + HL +               ERR +L   E
Sbjct: 1629 MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAE 1688

Query: 923  VLEMKQEALLAAISEKDANIALLELS--------------SSKKKTQEEVAALKREKDRL 968
            V E++          K A   LL+ S              ++KKK + +++ ++ E + +
Sbjct: 1689 VEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748

Query: 969  VQQLKQQTQNRMK------LMADNYEDDHFKSSHSNQTNHKPSPDQIIQPL-LELDQ 1018
            VQ+ +   +   K      +MA+  + +   S+H  +   K + +Q ++ L L LD+
Sbjct: 1749 VQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM--KKNMEQTVKDLQLRLDE 1803



 Score =  125 bits (315), Expect = 2e-28
 Identities = 174/799 (21%), Positives = 343/799 (42%), Gaps = 86/799 (10%)

Query: 309  IKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRF 368
            IK LL+  +++   A   EE  +    LA+ E     LE  +    +E + L+ ++    
Sbjct: 840  IKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEA 899

Query: 369  ENAPDSAKT--KALQTVIEMKDSKISSMERGLRDLEE---EIQMLKSNGALSTEEREEEM 423
            +   D+ +   + ++T I++ ++KI  +     D EE   E+   K        E ++++
Sbjct: 900  DALADAEERCDQLIKTKIQL-EAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDI 958

Query: 424  KQMEV----YRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKD 479
              +E+            +NKV+ L EE++  +    +L K+   LQ    Q   +L  ++
Sbjct: 959  DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEE 1018

Query: 480  TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALR--LRLEEKETM 537
                    K+ TLT   +  +Q ++ L+ SL  +++    L+     L   L+L ++ TM
Sbjct: 1019 D-------KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTM 1071

Query: 538  LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 597
              +  KQ                 L + L  KE +++ LQ KIE+ Q      +K++  L
Sbjct: 1072 DTENDKQ----------------QLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115

Query: 598  KERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID-NYKKDLKD 656
            + R++ L+ +      +    E+  ++  R +E + E+ +        +I+ N K++ + 
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF 1175

Query: 657  LKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME-S 715
             K +  L +  L  +  +    K+HA S+A  G + DS L+ ++  LE++K E LKME +
Sbjct: 1176 QKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDS-LQRVKQKLEKEKSE-LKMEIN 1233

Query: 716  QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
             L    E   +A+A         + E+     +D+ S+ + + +    ++ E+  +K   
Sbjct: 1234 DLASNMETVSKAKA---------NFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARL 1284

Query: 776  DKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKK 835
              +  E  RQ+ +++  V+ L   +Q       Q +EE +R+ +    +   L  +L+  
Sbjct: 1285 HTESGEFSRQLDEKDAMVSQLSRGKQA----FTQQIEELKRQLEEETKAKSTLAHALQSA 1340

Query: 836  DDRIEELEEALRESVQITAE--REMVLAQEESAR------TNAEKQVEELLMAMEKVKQE 887
                + L E   E  +  AE  R M  A  E A+      T+A ++ EEL  A +K+ Q 
Sbjct: 1341 RHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400

Query: 888  LESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI--ALL 945
            L+  +  + +     A  E     L+ E    + +V   +  A   A+ +K  N    L 
Sbjct: 1401 LQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV--ERSNAACIALDKKQRNFDKVLA 1458

Query: 946  ELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED--DHFKSSHSNQTNHK 1003
            E     ++TQ E+ A ++E   L  +L +        + + YE+  DH ++      N +
Sbjct: 1459 EWKQKYEETQAELEASQKESRSLSTELFK--------VKNAYEESLDHLETLKRENKNLQ 1510

Query: 1004 PSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENE 1063
                 + + + E  ++  +L+     L    H++  L           +L++ +A+ E+E
Sbjct: 1511 QEISDLTEQIAEGGKHIHELEKVKKQLD---HEKSEL---------QTSLEEAEASLEHE 1558

Query: 1064 LQKMTRGQLQDELEKGERD 1082
              K+ R QL+    K E D
Sbjct: 1559 EGKILRIQLELNQVKSEID 1577



 Score =  120 bits (301), Expect = 7e-27
 Identities = 155/776 (19%), Positives = 319/776 (41%), Gaps = 94/776 (12%)

Query: 199  ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC 258
            ALRK  A  +    EQ   +Q   Q ++     L+ E+    DL    +  S ++     
Sbjct: 1195 ALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN---DLASNMETVSKAKANFEK 1251

Query: 259  VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK----QTLNARDESIKKLLE 314
            +    E+    +  + E Q +    L   L   + R+ T+     + L+ +D  + +L  
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQR----LINELSAQKARLHTESGEFSRQLDEKDAMVSQL-- 1305

Query: 315  MLQSKGLSA---------KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH 365
               S+G  A         +  EE+ +    LA A     H   LL ++ +E    + E+ 
Sbjct: 1306 ---SRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQ 1362

Query: 366  RRFENAPDSA-------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
            R    A           +T A+Q   E++++K    +R L+D EE ++ + S  A S E+
Sbjct: 1363 RGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQDAEEHVEAVNSKCA-SLEK 1420

Query: 419  REEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQ----- 473
             ++ ++             N+VE L  ++    A    L KK       + + KQ     
Sbjct: 1421 TKQRLQ-------------NEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEET 1467

Query: 474  --ELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 531
              EL     E  +L T+L  + N + +S  H+E LK     +E +   LQ E+  L  ++
Sbjct: 1468 QAELEASQKESRSLSTELFKVKNAYEESLDHLETLK-----RENKN--LQQEISDLTEQI 1520

Query: 532  EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ----L 587
             E    +++  K  + +  EK      + + +  L+ +E K+  +Q ++  ++ +    +
Sbjct: 1521 AEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKI 1580

Query: 588  RDKEKQMSSLK-ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 646
             +K++++  LK   ++ +++  +  D  + +  +AL        R+K++ + D  E + +
Sbjct: 1581 AEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL--------RIKKKMEGDLNEMEIQ 1632

Query: 647  IDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQK 706
            +++  +   +    +   QG L + +  L D       L       + R   ++  +E+ 
Sbjct: 1633 LNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEEL 1692

Query: 707  KEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL---- 762
            +    + E   K A +  L+A      S+R+Q L  + T   +   K + ++ ++     
Sbjct: 1693 RASLERTERGRKMAEQELLDA------SERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746

Query: 763  EILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN-- 820
            +I++E  N +    K I +     ++  K+     H E++ KK   Q +++ + R D   
Sbjct: 1747 DIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM-KKNMEQTVKDLQLRLDEAE 1805

Query: 821  ---LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEEL 877
               L    +Q+Q    K + R+ ELE  +    +   E    L + E        Q EE 
Sbjct: 1806 QLALKGGKKQIQ----KLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEED 1861

Query: 878  LMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933
               + +++  ++ ++ K+ + ++   E E       A+ RK   E+ E K+ A +A
Sbjct: 1862 RKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADIA 1917



 Score =  101 bits (252), Expect = 3e-21
 Identities = 126/624 (20%), Positives = 269/624 (43%), Gaps = 72/624 (11%)

Query: 137  STVPHSLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKK 196
            ST+ H+L+ AR +  + L+ Q +E       L++ +    S+++      +T      ++
Sbjct: 1331 STLAHALQSARHDCDL-LREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE 1389

Query: 197  ERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGE 256
                +K  A ++   +E    V  +   ++ T Q LQ+E+    DL          R+  
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVE---DL-----MIDVERSNA 1441

Query: 257  PCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-QTLNARDESIKKLLE 314
             C+A +  + NF ++ AE +++ +E     +  ++    + T+  +  NA +ES+  L E
Sbjct: 1442 ACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL-E 1500

Query: 315  MLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDS 374
             L+ +  + +  +E  + T ++AE   H+H LE + +Q + E S L+  +    E + + 
Sbjct: 1501 TLKRENKNLQ--QEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEA-EASLEH 1557

Query: 375  AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
             + K L+  +E+   K S ++R + + +EE+  LK N     E  +  +      R+ + 
Sbjct: 1558 EEGKILRIQLELNQVK-SEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDAL 1616

Query: 435  FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
             +K K+E    +L+  E Q     ++AA     +   +  L  KDT+L            
Sbjct: 1617 RIKKKMEG---DLNEMEIQLNHANRQAAEALRNLRNTQGIL--KDTQL------------ 1659

Query: 495  QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE------------------- 535
               D+ +  + LKE L   E+RA ++Q EV+ LR  LE  E                   
Sbjct: 1660 HLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQL 1719

Query: 536  ------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVN---VLQKKIENLQEQ 586
                  +++N K K   D+++ +G     + + ++  +  ++ +    ++ ++++  Q+ 
Sbjct: 1720 LHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDT 1779

Query: 587  LRDKEKQMSSLKERVKSLQADTTNTDT-ALTTLEEALAEKERTIERLKEQRDRDEREKQE 645
                E+   ++++ VK LQ      +  AL   ++ + + E  +  L+ + + +++   E
Sbjct: 1780 SAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVE 1839

Query: 646  EIDNYKKDLKDLKE----------KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSR 695
             +   +K  + +KE           +  LQ  + + +  +   K  A           ++
Sbjct: 1840 AVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAK 1899

Query: 696  LKTLEIALEQKKEECLKMESQLKK 719
             + L+  LE+ KE     ESQ+ K
Sbjct: 1900 FRKLQHELEEAKERADIAESQVNK 1923


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  144 bits (362), Expect = 6e-34
 Identities = 201/957 (21%), Positives = 403/957 (42%), Gaps = 133/957 (13%)

Query: 142  SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
            +L++A   T+ DLQ +  +V   N L +  +++ E ++     S++      +  ERA R
Sbjct: 1004 ALQEAHQQTLDDLQAEEDKV---NTLTKAKIKL-EQQVDDLEGSLEQEKKLRMDLERAKR 1059

Query: 202  KDEASKITIWKEQYRVVQEENQHM-------QMTIQALQDELRIQRDLNQLFQQDSSSRT 254
            K E   + + +E    ++ E Q +       +  I  LQ ++  ++ L    Q+      
Sbjct: 1060 KLEGD-LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ 1118

Query: 255  G--EPCVAELTEENFQRLHAEHERQ--AKELFLLRKTLEEMELRIETQKQTLNARDESIK 310
               E    E+  E   R  AE +R   ++EL  + + LEE       Q +    R+   +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178

Query: 311  KLLEMLQSKGLSAKATEEDHERTRRLAEAEM--HVHHLESLLEQKEKENSMLREEMHRRF 368
            K+   L+   L  +AT     +    + AE+   + +L+ + ++ EKE S ++ E+    
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238

Query: 369  ENAPDSAKTKA--------LQTVIEMKDSKISSMERGLRDLEEEIQMLKS-NGALSTEER 419
             N    +K K         L+  +    SK    +R + DL  +   L++ +G  S +  
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298

Query: 420  EEEMKQMEVYRSHSKFMKNKVE---QLKEELSSKEA----------QWEELKKKAAGLQA 466
            E+E    ++ R    F +   E   QL+EE+ +K A            + L+++    Q 
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 467  EIGQVKQELSRKDTELLALQTKLET---------------LTNQFSDSKQHIEVLKESLT 511
               ++++ LS+ +TE+   +TK ET               L  +   +++H+E +     
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418

Query: 512  AKEQRAAILQTEVDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 568
            + E+    LQ EV+ L L +E        L+KK +    +  E   +  E H   +    
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1478

Query: 569  KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 628
            + R +     KI+N  E+  D   Q+ +LK   K+LQ +       ++ L E +AE  + 
Sbjct: 1479 EARSLGTELFKIKNAYEESLD---QLETLKRENKNLQQE-------ISDLTEQIAEGGKR 1528

Query: 629  I---ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS-----------EKEAS 674
            I   E++K+Q ++++ E Q  ++  +  L+  + K+  +Q +L+           EK+  
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 675  LLDLKE-HASSLASSGLKKDSRLKTLEIALEQKKE---ECLKMESQLKKAHEAALEARAS 730
            +  LK  H   + S     D+ +++   A+  KK+   +  +ME QL  A+  A EA  +
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648

Query: 731  PEMSDRI---------------QHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
               +  I               + L+ ++   +  ++  QAE++ L   L++ E  +   
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708

Query: 776  DKKIAELERQVK---DQNKKVANLKHKEQVE----KKKSAQMLEEARRREDNLNDS---S 825
            ++++ +   +V+    QN  + N K K + +    + +   +L+EAR  E+    +   +
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768

Query: 826  QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ-EESARTNAEKQVEELLMAMEKV 884
              + + L+K+ D    LE   +   Q   + ++ L + E+ A    +KQ+++L   + ++
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1828

Query: 885  KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            + E+ES + + +   + L              RKH   V E+  +      +E+D    +
Sbjct: 1829 EGEVESEQKRNAEAVKGL--------------RKHERRVKELTYQ------TEEDRK-NI 1867

Query: 945  LELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
            L L     K Q +V + KR+ +   +Q         KL  +  E +       +Q N
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924



 Score =  138 bits (347), Expect = 3e-32
 Identities = 180/870 (20%), Positives = 380/870 (43%), Gaps = 114/870 (13%)

Query: 191  SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS 250
            S E +KE A  K+E  KI     +    ++E +   +T+   +++L++Q         D+
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907

Query: 251  SSRTG---------EPCVAELTE--ENFQRLHAEHERQAKEL----FLLRKTLEEMELRI 295
              R           E  + E+TE  E+ + ++AE   + ++L      L+K ++++EL +
Sbjct: 908  EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967

Query: 296  ETQKQTLNARDESIKKLLEMLQSKGLS---AKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
               ++  +A +  +K L E  +  GL    AK T+E      + A  E H   L+ L  +
Sbjct: 968  AKVEKEKHATENKVKNLTE--EMAGLDETIAKLTKE------KKALQEAHQQTLDDLQAE 1019

Query: 353  KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
            ++K N++ + ++  + E   D      L+  +E +      +ER  R LE ++++ +   
Sbjct: 1020 EDKVNTLTKAKI--KLEQQVDD-----LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-- 1070

Query: 413  ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
              S  + E E +Q++      +F   ++  L+ ++  ++A   +L+KK   LQA I +++
Sbjct: 1071 --SIMDIENEKQQLDEKLKKKEF---EISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125

Query: 473  QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
            +E+  +       + +   L+ +  +  + +E    + +A+ +     + E   +R  LE
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185

Query: 533  EKETMLNKKT-----KQIQDMAEEKGTQAGEIHDLKDMLDVKERK-----------VNVL 576
            E  T+ ++ T     K+  D   E G Q   +  +K  L+ ++ +           V  +
Sbjct: 1186 E-ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETV 1244

Query: 577  QKKIENLQEQLRDKEKQMSSLKER-------VKSLQADTTNTDTALTTLEEALAEKERTI 629
             K   NL++  R  E Q+S LK +       +  L A      T        L EKE  +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

Query: 630  ERLK-------EQRDRDEREKQEEI---DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
             +L        +Q +  +R+ +EEI   +     L+  +    LL+    E++ S  +L+
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 739
               S   +   +  ++ +T  I   ++ EE  K  +Q  +A E  +EA     ++ +   
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA-----VNAKCAS 1419

Query: 740  LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV-ANLKH 798
            LE+   R ++E      +V+R       ++ ++ + DK +AE +++ ++ + ++ A+ K 
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 799  ---------KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 849
                     K +   ++S   LE  +R   NL      L + + +   RI ELE+  ++ 
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539

Query: 850  VQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
             Q   E +  L + E++  + E ++  + + + +VK E++          + +AEK+  +
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD----------RKIAEKDEEI 1589

Query: 910  TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK---REKD 966
              L   +R H+  ++E  Q  L A I  ++  I L      KKK + ++  ++      +
Sbjct: 1590 DQL---KRNHI-RIVESMQSTLDAEIRSRNDAIRL------KKKMEGDLNEMEIQLNHAN 1639

Query: 967  RLVQQLKQQTQNRMKLMADN--YEDDHFKS 994
            R+  +  +  +N   ++ D   + DD  +S
Sbjct: 1640 RMAAEALRNYRNTQGILKDTQIHLDDALRS 1669



 Score =  130 bits (326), Expect = 9e-30
 Identities = 140/637 (21%), Positives = 280/637 (43%), Gaps = 63/637 (9%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ +  ++EE Q +K   A S  +R+E  ++M         ++ +V+   E L+ 
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A+I +V +    ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   +   +  + K TK      E+K  Q      L D L  +
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK------EKKALQEAHQQTLDD-LQAE 1019

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
            E KVN L K    L++Q+ D E  +   K+    L+      +  L   +E++ +    I
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD----I 1075

Query: 630  ERLKEQRDRDEREKQEEIDN--------------YKKDLKDLKEKVSLLQGDLSEKEASL 675
            E  K+Q D   ++K+ EI N               +K +K+L+ ++  L+ ++  + AS 
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 676  LDLKEHASSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEAAL 725
               ++  S L+      S  L++     + +I + +K+E E  KM   L++A   HEA  
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 726  ------EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
                   A +  E+ ++I +L+R   + + E S+ + E+D L   ++ V   K + +K  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 780  AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
              LE Q+ +       LK KE+ +++    ++ +   +   L   S +    L +K+  +
Sbjct: 1256 RTLEDQLSE-------LKSKEEEQQR----LINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

Query: 840  EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 899
             +L    +   Q   E +  L +E  A+      ++      + ++++ E  +   +  Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364

Query: 900  QSLAEKETHLTNLRA-------ERRKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSK 951
            ++L++  T +   R        +R + LEE  +   + L AA    +A N     L  +K
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 952  KKTQEEVAALKREKDR---LVQQLKQQTQNRMKLMAD 985
            ++ Q EV  L  + +R       L ++ +N  K++A+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAE 1461



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 124/640 (19%), Positives = 269/640 (42%), Gaps = 89/640 (13%)

Query: 144  RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKD 203
            +QA    I +L+ QL+E ++  + L   ++             +     + + +RAL K 
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370

Query: 204  EASKITIWKEQYRV--------VQEENQHMQMTIQALQDEL---------------RIQR 240
              +++  W+ +Y          ++E  + +   +QA ++ +               R+Q 
Sbjct: 1371 N-TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 241  DLNQLFQQDSSSRTGEPCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
            ++  L       RT   C A +  + NF ++ AE +++ +E     +  ++    + T+ 
Sbjct: 1430 EVEDLMLD--VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487

Query: 300  QTL-NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENS 358
              + NA +ES+ +L E L+ +  + +  +E  + T ++AE    +H LE + +Q E+E  
Sbjct: 1488 FKIKNAYEESLDQL-ETLKRENKNLQ--QEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 359  MLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
             L+  +    E + +  + K L+  +E+   K S ++R + + +EEI  LK N     E 
Sbjct: 1545 ELQAALEEA-EASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQLKRNHIRIVES 1602

Query: 419  REEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
             +  +      R+ +  +K K+E    +L+  E Q     + AA         +  L  K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEG---DLNEMEIQLNHANRMAAEALRNYRNTQGIL--K 1657

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE--- 535
            DT++               D+ +  E LKE L   E+RA +LQ E++ LR  LE+ E   
Sbjct: 1658 DTQI------------HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1705

Query: 536  ----------------------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
                                  +++N K K   D+++ +G     + + ++  +  ++ +
Sbjct: 1706 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI 1765

Query: 574  N---VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT-ALTTLEEALAEKERTI 629
                ++ ++++  Q+     E+   ++++ VK LQ      +  AL   ++ + + E  +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 630  ERLKEQRDRDEREKQEEIDNYKKDLKDLKE----------KVSLLQGDLSEKEASLLDLK 679
              L+ + + +++   E +   +K  + +KE           +  LQ  + + +A +   K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
              A           ++ + L+  LE+ +E     ESQ+ K
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score =  144 bits (362), Expect = 6e-34
 Identities = 201/957 (21%), Positives = 403/957 (42%), Gaps = 133/957 (13%)

Query: 142  SLRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
            +L++A   T+ DLQ +  +V   N L +  +++ E ++     S++      +  ERA R
Sbjct: 1004 ALQEAHQQTLDDLQAEEDKV---NTLTKAKIKL-EQQVDDLEGSLEQEKKLRMDLERAKR 1059

Query: 202  KDEASKITIWKEQYRVVQEENQHM-------QMTIQALQDELRIQRDLNQLFQQDSSSRT 254
            K E   + + +E    ++ E Q +       +  I  LQ ++  ++ L    Q+      
Sbjct: 1060 KLEGD-LKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQ 1118

Query: 255  G--EPCVAELTEENFQRLHAEHERQ--AKELFLLRKTLEEMELRIETQKQTLNARDESIK 310
               E    E+  E   R  AE +R   ++EL  + + LEE       Q +    R+   +
Sbjct: 1119 ARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQ 1178

Query: 311  KLLEMLQSKGLSAKATEEDHERTRRLAEAEM--HVHHLESLLEQKEKENSMLREEMHRRF 368
            K+   L+   L  +AT     +    + AE+   + +L+ + ++ EKE S ++ E+    
Sbjct: 1179 KMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLA 1238

Query: 369  ENAPDSAKTKA--------LQTVIEMKDSKISSMERGLRDLEEEIQMLKS-NGALSTEER 419
             N    +K K         L+  +    SK    +R + DL  +   L++ +G  S +  
Sbjct: 1239 SNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLD 1298

Query: 420  EEEMKQMEVYRSHSKFMKNKVE---QLKEELSSKEA----------QWEELKKKAAGLQA 466
            E+E    ++ R    F +   E   QL+EE+ +K A            + L+++    Q 
Sbjct: 1299 EKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQE 1358

Query: 467  EIGQVKQELSRKDTELLALQTKLET---------------LTNQFSDSKQHIEVLKESLT 511
               ++++ LS+ +TE+   +TK ET               L  +   +++H+E +     
Sbjct: 1359 SKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCA 1418

Query: 512  AKEQRAAILQTEVDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 568
            + E+    LQ EV+ L L +E        L+KK +    +  E   +  E H   +    
Sbjct: 1419 SLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQK 1478

Query: 569  KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERT 628
            + R +     KI+N  E+  D   Q+ +LK   K+LQ +       ++ L E +AE  + 
Sbjct: 1479 EARSLGTELFKIKNAYEESLD---QLETLKRENKNLQQE-------ISDLTEQIAEGGKR 1528

Query: 629  I---ERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS-----------EKEAS 674
            I   E++K+Q ++++ E Q  ++  +  L+  + K+  +Q +L+           EK+  
Sbjct: 1529 IHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1588

Query: 675  LLDLKE-HASSLASSGLKKDSRLKTLEIALEQKKE---ECLKMESQLKKAHEAALEARAS 730
            +  LK  H   + S     D+ +++   A+  KK+   +  +ME QL  A+  A EA  +
Sbjct: 1589 IDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRN 1648

Query: 731  PEMSDRI---------------QHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
               +  I               + L+ ++   +  ++  QAE++ L   L++ E  +   
Sbjct: 1649 YRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIA 1708

Query: 776  DKKIAELERQVK---DQNKKVANLKHKEQVE----KKKSAQMLEEARRREDNLNDS---S 825
            ++++ +   +V+    QN  + N K K + +    + +   +L+EAR  E+    +   +
Sbjct: 1709 EQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDA 1768

Query: 826  QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQ-EESARTNAEKQVEELLMAMEKV 884
              + + L+K+ D    LE   +   Q   + ++ L + E+ A    +KQ+++L   + ++
Sbjct: 1769 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1828

Query: 885  KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            + E+ES + + +   + L              RKH   V E+  +      +E+D    +
Sbjct: 1829 EGEVESEQKRNAEAVKGL--------------RKHERRVKELTYQ------TEEDRK-NI 1867

Query: 945  LELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
            L L     K Q +V + KR+ +   +Q         KL  +  E +       +Q N
Sbjct: 1868 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVN 1924



 Score =  138 bits (347), Expect = 3e-32
 Identities = 180/870 (20%), Positives = 380/870 (43%), Gaps = 114/870 (13%)

Query: 191  SPELKKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDS 250
            S E +KE A  K+E  KI     +    ++E +   +T+   +++L++Q         D+
Sbjct: 848  SAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADA 907

Query: 251  SSRTG---------EPCVAELTE--ENFQRLHAEHERQAKEL----FLLRKTLEEMELRI 295
              R           E  + E+TE  E+ + ++AE   + ++L      L+K ++++EL +
Sbjct: 908  EERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 967

Query: 296  ETQKQTLNARDESIKKLLEMLQSKGLS---AKATEEDHERTRRLAEAEMHVHHLESLLEQ 352
               ++  +A +  +K L E  +  GL    AK T+E      + A  E H   L+ L  +
Sbjct: 968  AKVEKEKHATENKVKNLTE--EMAGLDETIAKLTKE------KKALQEAHQQTLDDLQAE 1019

Query: 353  KEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNG 412
            ++K N++ + ++  + E   D      L+  +E +      +ER  R LE ++++ +   
Sbjct: 1020 EDKVNTLTKAKI--KLEQQVDD-----LEGSLEQEKKLRMDLERAKRKLEGDLKLAQE-- 1070

Query: 413  ALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVK 472
              S  + E E +Q++      +F   ++  L+ ++  ++A   +L+KK   LQA I +++
Sbjct: 1071 --SIMDIENEKQQLDEKLKKKEF---EISNLQSKIEDEQALGIQLQKKIKELQARIEELE 1125

Query: 473  QELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLE 532
            +E+  +       + +   L+ +  +  + +E    + +A+ +     + E   +R  LE
Sbjct: 1126 EEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLE 1185

Query: 533  EKETMLNKKT-----KQIQDMAEEKGTQAGEIHDLKDMLDVKERK-----------VNVL 576
            E  T+ ++ T     K+  D   E G Q   +  +K  L+ ++ +           V  +
Sbjct: 1186 E-ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETV 1244

Query: 577  QKKIENLQEQLRDKEKQMSSLKER-------VKSLQADTTNTDTALTTLEEALAEKERTI 629
             K   NL++  R  E Q+S LK +       +  L A      T        L EKE  +
Sbjct: 1245 SKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

Query: 630  ERLK-------EQRDRDEREKQEEI---DNYKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
             +L        +Q +  +R+ +EEI   +     L+  +    LL+    E++ S  +L+
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQH 739
               S   +   +  ++ +T  I   ++ EE  K  +Q  +A E  +EA     ++ +   
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEA-----VNAKCAS 1419

Query: 740  LEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKV-ANLKH 798
            LE+   R ++E      +V+R       ++ ++ + DK +AE +++ ++ + ++ A+ K 
Sbjct: 1420 LEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKE 1479

Query: 799  ---------KEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRES 849
                     K +   ++S   LE  +R   NL      L + + +   RI ELE+  ++ 
Sbjct: 1480 ARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1539

Query: 850  VQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHL 909
             Q   E +  L + E++  + E ++  + + + +VK E++          + +AEK+  +
Sbjct: 1540 EQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD----------RKIAEKDEEI 1589

Query: 910  TNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK---REKD 966
              L   +R H+  ++E  Q  L A I  ++  I L      KKK + ++  ++      +
Sbjct: 1590 DQL---KRNHI-RIVESMQSTLDAEIRSRNDAIRL------KKKMEGDLNEMEIQLNHAN 1639

Query: 967  RLVQQLKQQTQNRMKLMADN--YEDDHFKS 994
            R+  +  +  +N   ++ D   + DD  +S
Sbjct: 1640 RMAAEALRNYRNTQGILKDTQIHLDDALRS 1669



 Score =  130 bits (326), Expect = 9e-30
 Identities = 140/637 (21%), Positives = 280/637 (43%), Gaps = 63/637 (9%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ +  ++EE Q +K   A S  +R+E  ++M         ++ +V+   E L+ 
Sbjct: 847  KSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLAD 906

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A+I +V +    ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 907  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 966

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   +   +  + K TK      E+K  Q      L D L  +
Sbjct: 967  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK------EKKALQEAHQQTLDD-LQAE 1019

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
            E KVN L K    L++Q+ D E  +   K+    L+      +  L   +E++ +    I
Sbjct: 1020 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMD----I 1075

Query: 630  ERLKEQRDRDEREKQEEIDN--------------YKKDLKDLKEKVSLLQGDLSEKEASL 675
            E  K+Q D   ++K+ EI N               +K +K+L+ ++  L+ ++  + AS 
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASR 1135

Query: 676  LDLKEHASSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEAAL 725
               ++  S L+      S  L++     + +I + +K+E E  KM   L++A   HEA  
Sbjct: 1136 AKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1195

Query: 726  ------EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKI 779
                   A +  E+ ++I +L+R   + + E S+ + E+D L   ++ V   K + +K  
Sbjct: 1196 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMC 1255

Query: 780  AELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRI 839
              LE Q+ +       LK KE+ +++    ++ +   +   L   S +    L +K+  +
Sbjct: 1256 RTLEDQLSE-------LKSKEEEQQR----LINDLTAQRGRLQTESGEFSRQLDEKEALV 1304

Query: 840  EELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQ 899
             +L    +   Q   E +  L +E  A+      ++      + ++++ E  +   +  Q
Sbjct: 1305 SQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQ 1364

Query: 900  QSLAEKETHLTNLRA-------ERRKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSK 951
            ++L++  T +   R        +R + LEE  +   + L AA    +A N     L  +K
Sbjct: 1365 RALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTK 1424

Query: 952  KKTQEEVAALKREKDR---LVQQLKQQTQNRMKLMAD 985
            ++ Q EV  L  + +R       L ++ +N  K++A+
Sbjct: 1425 QRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAE 1461



 Score = 98.6 bits (244), Expect = 3e-20
 Identities = 124/640 (19%), Positives = 269/640 (42%), Gaps = 89/640 (13%)

Query: 144  RQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKD 203
            +QA    I +L+ QL+E ++  + L   ++             +     + + +RAL K 
Sbjct: 1311 KQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKA 1370

Query: 204  EASKITIWKEQYRV--------VQEENQHMQMTIQALQDEL---------------RIQR 240
              +++  W+ +Y          ++E  + +   +QA ++ +               R+Q 
Sbjct: 1371 N-TEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQN 1429

Query: 241  DLNQLFQQDSSSRTGEPCVA-ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK 299
            ++  L       RT   C A +  + NF ++ AE +++ +E     +  ++    + T+ 
Sbjct: 1430 EVEDLMLD--VERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTEL 1487

Query: 300  QTL-NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENS 358
              + NA +ES+ +L E L+ +  + +  +E  + T ++AE    +H LE + +Q E+E  
Sbjct: 1488 FKIKNAYEESLDQL-ETLKRENKNLQ--QEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544

Query: 359  MLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE 418
             L+  +    E + +  + K L+  +E+   K S ++R + + +EEI  LK N     E 
Sbjct: 1545 ELQAALEEA-EASLEHEEGKILRIQLELNQVK-SEVDRKIAEKDEEIDQLKRNHIRIVES 1602

Query: 419  REEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
             +  +      R+ +  +K K+E    +L+  E Q     + AA         +  L  K
Sbjct: 1603 MQSTLDAEIRSRNDAIRLKKKMEG---DLNEMEIQLNHANRMAAEALRNYRNTQGIL--K 1657

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKE--- 535
            DT++               D+ +  E LKE L   E+RA +LQ E++ LR  LE+ E   
Sbjct: 1658 DTQI------------HLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1705

Query: 536  ----------------------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
                                  +++N K K   D+++ +G     + + ++  +  ++ +
Sbjct: 1706 KIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAI 1765

Query: 574  N---VLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDT-ALTTLEEALAEKERTI 629
                ++ ++++  Q+     E+   ++++ VK LQ      +  AL   ++ + + E  +
Sbjct: 1766 TDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARV 1825

Query: 630  ERLKEQRDRDEREKQEEIDNYKKDLKDLKE----------KVSLLQGDLSEKEASLLDLK 679
              L+ + + +++   E +   +K  + +KE           +  LQ  + + +A +   K
Sbjct: 1826 RELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYK 1885

Query: 680  EHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 719
              A           ++ + L+  LE+ +E     ESQ+ K
Sbjct: 1886 RQAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNK 1925


>gi|118498356 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  142 bits (359), Expect = 1e-33
 Identities = 181/836 (21%), Positives = 374/836 (44%), Gaps = 91/836 (10%)

Query: 145  QARDNTIMDLQTQLKEVLRENDLLRKDVE---------VKESKLSSSMNSIKTFWSPELK 195
            Q R N    LQ Q++++L +N+ L+  ++            S L+  ++ +      ++K
Sbjct: 558  QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617

Query: 196  KERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQLFQQ--- 248
            +       E  ++T  +E+ + +Q  N  ++  +Q LQ    ++     +L ++ Q    
Sbjct: 618  QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677

Query: 249  --DSSSRTGEPCVAELTE--ENFQRLHAEHERQAKELFLLRKTLEEMELR--IETQKQTL 302
              D      E    E++   E F+ L+ +++    E+  L+  + E   +  +E  ++ +
Sbjct: 678  KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737

Query: 303  NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSM--- 359
              +DE +K + E+L++ GL   AT+E+     R   + +     + + + K K+N     
Sbjct: 738  QEKDEKLKTVEELLET-GLIQVATKEEELNAIRTENSSL----TKEVQDLKAKQNDQVSF 792

Query: 360  --LREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
              L EE+ +         K K+++ ++E +  K+++ E+ ++DL++EI+ LK        
Sbjct: 793  ASLVEELKKVIHEK--DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALK-------- 842

Query: 418  EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
               EE+  +++ ++    + +KV++L+  L  KE Q   +K       A + + +++L+ 
Sbjct: 843  ---EEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK-------AVLEEKEKDLAN 892

Query: 478  KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK--EQRAAIL---QTEVDALRLRLE 532
                L  LQ + E+L     +  QH   LKE+ +A   E+   +L   + E+  L   L+
Sbjct: 893  TGKWLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEELEIVLKEKENELKRLEAMLK 950

Query: 533  EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV---NVLQKKIENLQEQLRD 589
            E+E+ L+ KT+ +QD+ +E      +I  LK     +         L K I   ++++  
Sbjct: 951  ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010

Query: 590  KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID- 648
               ++ SLK+ V+  +    +         EALA  E+    L+++ ++  +E+Q++++ 
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK---MLQDKVNKTSKERQQQVEA 1067

Query: 649  ---NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 705
                 K+ LK L  KVS +  +LS  E   L   E  +    +G      +K LE  L++
Sbjct: 1068 VELEAKEVLKKLFPKVS-VPSNLSYGE--WLHGFEKKAKECMAGTSGSEEVKVLEHKLKE 1124

Query: 706  KKE-------ECLKMESQLKKAHEAALEARASPEMSD-----RIQHLEREITRYKDESSK 753
              E       EC K +S L +      + + S E  +     ++    + I + +   + 
Sbjct: 1125 ADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTS 1184

Query: 754  AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV---EKKKSAQM 810
            ++ E++RL    K++EN + +++    ELE+   +++  V  ++  + +    +KK    
Sbjct: 1185 SEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDS 1244

Query: 811  LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
              EA R+ + LN    QL ++L K   R E+ E          A++ + L Q +  +   
Sbjct: 1245 YSEAVRQNEELNLLKAQLNETLTKL--RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1302

Query: 871  EKQV-EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
            +  V E   ++ E    E E+M   L+ T   L ++     N +  + K   +VLE
Sbjct: 1303 DTTVIENSDVSPETESSEKETMSVSLNQTVTQL-QQLLQAVNQQLTKEKEHYQVLE 1357



 Score =  135 bits (339), Expect = 3e-31
 Identities = 183/902 (20%), Positives = 392/902 (43%), Gaps = 112/902 (12%)

Query: 153  DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
            ++Q+ +++   E++  ++D++ K     + + S+ +  +  L  ++ L  ++     +  
Sbjct: 499  EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL--EQRLMQLMES 556

Query: 213  EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
            EQ RV +EE+  MQ+     QD L     L    QQ  S    +   + L EE   ++ A
Sbjct: 557  EQKRVNKEESLQMQV-----QDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-LHKVIA 610

Query: 273  EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM-----LQSKGLSAKATE 327
            E ++Q K+           E  + +++  L +++E +K +  M      + + L A A E
Sbjct: 611  EKDKQIKQT----------EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660

Query: 328  ED---HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH-RRFENAPDSAKTKALQTV 383
            +    HE  +      +    +  L EQ + E S   EE      +N    ++ + LQT+
Sbjct: 661  QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720

Query: 384  IEMKDSK--ISSMERGLRDLEEE---IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
            +  + +K  +  ME+ +++ +E+   ++ L   G +    +EEE+  +   R+ +  +  
Sbjct: 721  VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI---RTENSSLTK 777

Query: 439  KVEQLKEELSSK---EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495
            +V+ LK + + +    +  EELKK    +  + G++K      + ELL +  K +T+   
Sbjct: 778  EVQDLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTV--- 831

Query: 496  FSDSKQHIEVLKE-------------SLTAKEQRAAIL----QTEVDALRLRLEEKETML 538
              D KQ I+ LKE             S+T+K Q    L    + +++ ++  LEEKE  L
Sbjct: 832  -QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
                K +QD+ EE  +    + ++    ++KE        + E L+  L++KE ++  L+
Sbjct: 891  ANTGKWLQDLQEENESLKAHVQEVAQH-NLKEASS---ASQFEELEIVLKEKENELKRLE 946

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER-------------EKQE 645
              +K  ++D ++    L  +++     +  IE+LK+Q  +                E+++
Sbjct: 947  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006

Query: 646  EIDNYKKDLKDLKEKVSLLQ---GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI- 701
            EI     +L  LK+ V   +    DL EK    ++       +    + K S+ +  ++ 
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1066

Query: 702  ALEQKKEECLK-------MESQLKKAH------EAALEARASPEMSDRIQHLEREITRYK 748
            A+E + +E LK       + S L          + A E  A    S+ ++ LE ++    
Sbjct: 1067 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126

Query: 749  DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 808
            +  +  Q E ++   +L E E         + +L+R V+ +  K      +     K+  
Sbjct: 1127 EMHTLLQLECEKYKSVLAETEGI-------LQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1179

Query: 809  QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA-LRESVQITAEREMVLAQEESAR 867
                 + +  + L   ++ +++  R+++    ELE+A +  S  +T  RE+     +   
Sbjct: 1180 SSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL-----KDLL 1234

Query: 868  TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK 927
            T  +K++++      +  +EL  +KA+L+ T   L  ++     +  +  K  ++ LE+ 
Sbjct: 1235 TELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK-AQQSLELI 1293

Query: 928  QEALLAAISEKDANIALLELSSSKKKTQEEVAALK-REKDRLVQQLKQQTQNRMKLMADN 986
            Q  ++ A  +    I   ++S   + +++E  ++   +    +QQL Q    ++    ++
Sbjct: 1294 QSKIVKAAGDTTV-IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEH 1352

Query: 987  YE 988
            Y+
Sbjct: 1353 YQ 1354



 Score =  134 bits (338), Expect = 4e-31
 Identities = 172/775 (22%), Positives = 343/775 (44%), Gaps = 83/775 (10%)

Query: 258  CVAELTEENFQRLHAEHERQAK-ELFLLRKTLEEMELRIETQKQTLNARDESIKKLL-EM 315
            CV +L +E    +    ++ +K EL  L   L+E +  +   K+   A  +  K+L  EM
Sbjct: 303  CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM 362

Query: 316  LQSKGLS------AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFE 369
            +  K  S       K      E+   + + ++HV + E+  +Q + +   +RE+M    E
Sbjct: 363  MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQET--QQMQMKFQQVREQMEA--E 418

Query: 370  NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
             A    +   L+  +    +++ S +        E+  L+ + A    E  E+  +++  
Sbjct: 419  IAHLKQENGILRDAVSNTTNQLESKQSA------ELNKLRQDYARLVNELTEKTGKLQQE 472

Query: 430  RSHSKFMKNKVEQLKEELSSKEAQWEE----LKKKAAGLQAEIGQVKQELSRKDTELLAL 485
                K  +    QLK +L   E +WEE    ++K+ A  +A    ++ +   K+ E+ +L
Sbjct: 473  EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532

Query: 486  QTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQI 545
             +KL          +Q +  L ES   +  +   LQ +V  +   LE+ E  L  + +Q 
Sbjct: 533  HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDI---LEQNEA-LKAQIQQF 588

Query: 546  QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS-------LK 598
                  + + +    +L  ++  K++++   +  + + +++L  KE+++         LK
Sbjct: 589  HSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLK 648

Query: 599  ERVKSLQADTTNTDTA---LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
              V+ LQA       A   L  +++++  K+  I  L+EQ   +   K EE        K
Sbjct: 649  AEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNK 708

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715
             LK +V  LQ  +SE+       K+    +     +KD +LKT+E  LE    +    E 
Sbjct: 709  ALKSEVQKLQTLVSEQPN-----KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763

Query: 716  QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
            +L      A+    S  ++  +Q L+    +  D+ S A      L+E LK+V +EK+ K
Sbjct: 764  ELN-----AIRTENS-SLTKEVQDLK---AKQNDQVSFAS-----LVEELKKVIHEKDGK 809

Query: 776  DKKIAELER----QVKDQNKKVANLKHKEQVEKKKSAQM-LEEARRREDNLNDSSQQLQD 830
             K + EL      +V ++ K V +LK + +  K++   + LE+A++   ++    Q+LQ+
Sbjct: 810  IKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL--SITSKVQELQN 867

Query: 831  SLRKKDDRIEELEEALRESVQ-----------ITAEREMV------LAQEESARTNAEKQ 873
             L+ K++++  ++  L E  +           +  E E +      +AQ      ++  Q
Sbjct: 868  LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ 927

Query: 874  VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933
             EEL + +++ + EL+ ++A L   +  L+ K   L +++ E +    ++ ++KQ+    
Sbjct: 928  FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ 987

Query: 934  AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 988
            A S    +  LL++ S ++K   E++ L  E D L   ++ Q +    L   N+E
Sbjct: 988  A-SSFPPHEELLKVISEREK---EISGLWNELDSLKDAVEHQRKKNNDLREKNWE 1038



 Score =  117 bits (294), Expect = 5e-26
 Identities = 159/720 (22%), Positives = 324/720 (45%), Gaps = 78/720 (10%)

Query: 414  LSTEEREEEMKQMEVYRSHSKF--MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQV 471
            + T E+E  + Q +++ S+ +   M+ K +Q++E++   EA+   LK++   L+  +   
Sbjct: 380  IGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---EAEIAHLKQENGILRDAVSNT 436

Query: 472  KQEL-SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 530
              +L S++  EL  L+     L N+ ++    ++  +      EQ A  L+ ++     R
Sbjct: 437  TNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496

Query: 531  LEEKETMLNKKTKQI----QDMAEEKGTQAGEIHDLKDML--------DVKERKVNVLQK 578
             EE ++ + K+T +     QD+  +   +  E+  L   L         +++R + +++ 
Sbjct: 497  WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556

Query: 579  ------KIENLQEQLRDKEKQMSSLKERVKSLQ---ADTTNTDTALTTLEEALAEKERTI 629
                  K E+LQ Q++D  +Q  +LK +++      A  T+       L + +AEK++ I
Sbjct: 557  EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616

Query: 630  ER----LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL 685
            ++    L  +RDR    K+EE+ + +     LK +V  LQ   +E+ A+  +L++   S+
Sbjct: 617  KQTEDSLASERDR-LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675

Query: 686  ASSGLKKDSRLKTLEIALEQ----KKEECLKMESQLK--KAHEAALEARASPEMSDRIQH 739
                  KD +++ LE  L+     K EE   +  Q K  K+    L+   S + +  +  
Sbjct: 676  ----YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731

Query: 740  LEREITRYKDESSKAQAEVDRLLEI-LKEVENEKNDKDKKIAELERQVKDQNKKVANLKH 798
               +  + KDE  K    V+ LLE  L +V      K++++  +  +     K+V +LK 
Sbjct: 732  QMEKCIQEKDEKLKT---VEELLETGLIQVAT----KEEELNAIRTENSSLTKEVQDLKA 784

Query: 799  KEQVEKKKSAQMLEEARR---REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 855
            K+  ++   A ++EE ++    +D    S ++L ++   K    E+  + L++ ++   E
Sbjct: 785  KQN-DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE 843

Query: 856  REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915
                +  E++ + +   +V+EL   ++  ++++ +MKA L   ++ LA     L +L+ E
Sbjct: 844  EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 903

Query: 916  R---RKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQ-- 970
                + H++EV +   +   +A   ++  I L E  +  K+ +   A LK  +  L    
Sbjct: 904  NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE---AMLKERESDLSSKT 960

Query: 971  QLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHL 1030
            QL Q  Q+  KL     E    K  +  Q +  P  +++++ + E ++  S L   +  L
Sbjct: 961  QLLQDVQDENKLFKSQIE--QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL 1018

Query: 1031 -TTLCHDRDPLILRGLTPPASYNLDDDQAAWE-NELQKMTRGQLQDELEKGERDNAELQE 1088
               + H R              N D  +  WE  E    T   LQD++ K  ++  +  E
Sbjct: 1019 KDAVEHQR------------KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1066



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 92/455 (20%), Positives = 189/455 (41%), Gaps = 66/455 (14%)

Query: 141  HSLRQARD-NTIMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKT------FWS 191
            H+L++A   +   +L+  LKE  +EN+L R +  +KE  S LSS    ++        + 
Sbjct: 917  HNLKEASSASQFEELEIVLKE--KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974

Query: 192  PELKKERALRKDEASKITIWKEQYRVVQEENQHMQ---MTIQALQDELRIQRDLNQLFQQ 248
             ++++ +     +AS     +E  +V+ E  + +      + +L+D +  QR  N     
Sbjct: 975  SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN---- 1030

Query: 249  DSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES 308
                        +L E+N++ + A    +      + KT +E + ++E  +  L A+ E 
Sbjct: 1031 ------------DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE--LEAK-EV 1075

Query: 309  IKKL---------------LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
            +KKL               L   + K     A     E  + L         + +LL+ +
Sbjct: 1076 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 354  -EKENSMLRE------EMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQ 406
             EK  S+L E      ++ R  E   +  K K     ++     I  M+      E+E++
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVK-----VDESHKTIKQMQSSFTSSEQELE 1190

Query: 407  MLKS-NGALSTEEREEEMKQMEVYRSHSKFMK--NKVEQLKEELSSKEAQWEELKKKAAG 463
             L+S N  +    RE E  +ME+ ++  +      +V +LK+ L+  + + ++   +A  
Sbjct: 1191 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250

Query: 464  LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
               E+  +K +L+   T+L   Q + + +      ++Q +E+++  +        +++  
Sbjct: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310

Query: 524  VDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQ 555
              +      EKETM   LN+   Q+Q + +    Q
Sbjct: 1311 DVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 127/635 (20%), Positives = 247/635 (38%), Gaps = 112/635 (17%)

Query: 504  EVLKESLTAKEQRAA-ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 562
            E L + + AK++R   ++ T+ D  + + E+K+    KK  Q  ++ E           L
Sbjct: 31   ETLYDEVLAKQKREQKLIPTKTD--KKKAEKKKN--KKKEIQNGNLHESDSESVPRDFKL 86

Query: 563  KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
             D L V++ +V  +   +      +R+++K+    +++ K +  +    ++  + +    
Sbjct: 87   SDALAVEDDQVAPVPLNVVETSSSVRERKKK----EKKQKPVLEEQVIKESDASKIPGKK 142

Query: 623  AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
             E     ++     +    +K+      K    D  +KV  L      +EA  L L +  
Sbjct: 143  VEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEA--LPLHQET 200

Query: 683  SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAAL--EARASPEMS------ 734
               + SG KK S  K       QK E     E  +       L   A +SP +       
Sbjct: 201  KQESGSGKKKASSKK-------QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVID 253

Query: 735  ----DRIQHLEREITR-YKDESSKAQAEV---DRLL----------------EILKEVEN 770
                D+++ +++  T+  K E+ K  AEV   D LL                ++LKE   
Sbjct: 254  LLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSG 313

Query: 771  EKNDKDKK-----IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS 825
               D  KK     +  L  Q+++++K +A +K      K +  Q+ +E    ++  N   
Sbjct: 314  VIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVI 373

Query: 826  QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 885
             +++D +   +      +  +  S Q T + +M   Q    R   E ++  L       K
Sbjct: 374  TRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ---VREQMEAEIAHL-------K 423

Query: 886  QELESMKAKLSSTQQSLAEKET-HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            QE   ++  +S+T   L  K++  L  LR +  + + E+ E   +     + +K+A  A 
Sbjct: 424  QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA 483

Query: 945  LELSSSKKKTQ---EEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
             +L    ++ +   EEV +  R++    +  +Q  Q++        +++  +S HS  T+
Sbjct: 484  TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA-----KENEVQSLHSKLTD 538

Query: 1002 HKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWE 1061
               S  Q+ Q L++L ++  K                                  +   E
Sbjct: 539  TLVSKQQLEQRLMQLMESEQK----------------------------------RVNKE 564

Query: 1062 NELQKMTRGQLQDELEKGERDNAELQEFANAILQQ 1096
              LQ     Q+QD LE+ E   A++Q+F + I  Q
Sbjct: 565  ESLQM----QVQDILEQNEALKAQIQQFHSQIAAQ 595


>gi|33620775 kinectin 1 isoform a [Homo sapiens]
          Length = 1357

 Score =  142 bits (359), Expect = 1e-33
 Identities = 181/836 (21%), Positives = 374/836 (44%), Gaps = 91/836 (10%)

Query: 145  QARDNTIMDLQTQLKEVLRENDLLRKDVE---------VKESKLSSSMNSIKTFWSPELK 195
            Q R N    LQ Q++++L +N+ L+  ++            S L+  ++ +      ++K
Sbjct: 558  QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617

Query: 196  KERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQ----DELRIQRDLNQLFQQ--- 248
            +       E  ++T  +E+ + +Q  N  ++  +Q LQ    ++     +L ++ Q    
Sbjct: 618  QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677

Query: 249  --DSSSRTGEPCVAELTE--ENFQRLHAEHERQAKELFLLRKTLEEMELR--IETQKQTL 302
              D      E    E++   E F+ L+ +++    E+  L+  + E   +  +E  ++ +
Sbjct: 678  KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737

Query: 303  NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSM--- 359
              +DE +K + E+L++ GL   AT+E+     R   + +     + + + K K+N     
Sbjct: 738  QEKDEKLKTVEELLET-GLIQVATKEEELNAIRTENSSL----TKEVQDLKAKQNDQVSF 792

Query: 360  --LREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
              L EE+ +         K K+++ ++E +  K+++ E+ ++DL++EI+ LK        
Sbjct: 793  ASLVEELKKVIHEK--DGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALK-------- 842

Query: 418  EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
               EE+  +++ ++    + +KV++L+  L  KE Q   +K       A + + +++L+ 
Sbjct: 843  ---EEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK-------AVLEEKEKDLAN 892

Query: 478  KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAK--EQRAAIL---QTEVDALRLRLE 532
                L  LQ + E+L     +  QH   LKE+ +A   E+   +L   + E+  L   L+
Sbjct: 893  TGKWLQDLQEENESLKAHVQEVAQH--NLKEASSASQFEELEIVLKEKENELKRLEAMLK 950

Query: 533  EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV---NVLQKKIENLQEQLRD 589
            E+E+ L+ KT+ +QD+ +E      +I  LK     +         L K I   ++++  
Sbjct: 951  ERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISG 1010

Query: 590  KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEID- 648
               ++ SLK+ V+  +    +         EALA  E+    L+++ ++  +E+Q++++ 
Sbjct: 1011 LWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK---MLQDKVNKTSKERQQQVEA 1067

Query: 649  ---NYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQ 705
                 K+ LK L  KVS +  +LS  E   L   E  +    +G      +K LE  L++
Sbjct: 1068 VELEAKEVLKKLFPKVS-VPSNLSYGE--WLHGFEKKAKECMAGTSGSEEVKVLEHKLKE 1124

Query: 706  KKE-------ECLKMESQLKKAHEAALEARASPEMSD-----RIQHLEREITRYKDESSK 753
              E       EC K +S L +      + + S E  +     ++    + I + +   + 
Sbjct: 1125 ADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTS 1184

Query: 754  AQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQV---EKKKSAQM 810
            ++ E++RL    K++EN + +++    ELE+   +++  V  ++  + +    +KK    
Sbjct: 1185 SEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDS 1244

Query: 811  LEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
              EA R+ + LN    QL ++L K   R E+ E          A++ + L Q +  +   
Sbjct: 1245 YSEAVRQNEELNLLKAQLNETLTKL--RTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1302

Query: 871  EKQV-EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLE 925
            +  V E   ++ E    E E+M   L+ T   L ++     N +  + K   +VLE
Sbjct: 1303 DTTVIENSDVSPETESSEKETMSVSLNQTVTQL-QQLLQAVNQQLTKEKEHYQVLE 1357



 Score =  135 bits (339), Expect = 3e-31
 Identities = 183/902 (20%), Positives = 392/902 (43%), Gaps = 112/902 (12%)

Query: 153  DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
            ++Q+ +++   E++  ++D++ K     + + S+ +  +  L  ++ L  ++     +  
Sbjct: 499  EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQL--EQRLMQLMES 556

Query: 213  EQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHA 272
            EQ RV +EE+  MQ+     QD L     L    QQ  S    +   + L EE   ++ A
Sbjct: 557  EQKRVNKEESLQMQV-----QDILEQNEALKAQIQQFHSQIAAQTSASVLAEE-LHKVIA 610

Query: 273  EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEM-----LQSKGLSAKATE 327
            E ++Q K+           E  + +++  L +++E +K +  M      + + L A A E
Sbjct: 611  EKDKQIKQT----------EDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660

Query: 328  ED---HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMH-RRFENAPDSAKTKALQTV 383
            +    HE  +      +    +  L EQ + E S   EE      +N    ++ + LQT+
Sbjct: 661  QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720

Query: 384  IEMKDSK--ISSMERGLRDLEEE---IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKN 438
            +  + +K  +  ME+ +++ +E+   ++ L   G +    +EEE+  +   R+ +  +  
Sbjct: 721  VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI---RTENSSLTK 777

Query: 439  KVEQLKEELSSK---EAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQ 495
            +V+ LK + + +    +  EELKK    +  + G++K      + ELL +  K +T+   
Sbjct: 778  EVQDLKAKQNDQVSFASLVEELKKV---IHEKDGKIKSVEELLEAELLKVANKEKTV--- 831

Query: 496  FSDSKQHIEVLKE-------------SLTAKEQRAAIL----QTEVDALRLRLEEKETML 538
              D KQ I+ LKE             S+T+K Q    L    + +++ ++  LEEKE  L
Sbjct: 832  -QDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL 890

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
                K +QD+ EE  +    + ++    ++KE        + E L+  L++KE ++  L+
Sbjct: 891  ANTGKWLQDLQEENESLKAHVQEVAQH-NLKEASS---ASQFEELEIVLKEKENELKRLE 946

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER-------------EKQE 645
              +K  ++D ++    L  +++     +  IE+LK+Q  +                E+++
Sbjct: 947  AMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006

Query: 646  EIDNYKKDLKDLKEKVSLLQ---GDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI- 701
            EI     +L  LK+ V   +    DL EK    ++       +    + K S+ +  ++ 
Sbjct: 1007 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1066

Query: 702  ALEQKKEECLK-------MESQLKKAH------EAALEARASPEMSDRIQHLEREITRYK 748
            A+E + +E LK       + S L          + A E  A    S+ ++ LE ++    
Sbjct: 1067 AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126

Query: 749  DESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSA 808
            +  +  Q E ++   +L E E         + +L+R V+ +  K      +     K+  
Sbjct: 1127 EMHTLLQLECEKYKSVLAETEGI-------LQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1179

Query: 809  QMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA-LRESVQITAEREMVLAQEESAR 867
                 + +  + L   ++ +++  R+++    ELE+A +  S  +T  RE+     +   
Sbjct: 1180 SSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL-----KDLL 1234

Query: 868  TNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMK 927
            T  +K++++      +  +EL  +KA+L+ T   L  ++     +  +  K  ++ LE+ 
Sbjct: 1235 TELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK-AQQSLELI 1293

Query: 928  QEALLAAISEKDANIALLELSSSKKKTQEEVAALK-REKDRLVQQLKQQTQNRMKLMADN 986
            Q  ++ A  +    I   ++S   + +++E  ++   +    +QQL Q    ++    ++
Sbjct: 1294 QSKIVKAAGDTTV-IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEH 1352

Query: 987  YE 988
            Y+
Sbjct: 1353 YQ 1354



 Score =  134 bits (338), Expect = 4e-31
 Identities = 172/775 (22%), Positives = 343/775 (44%), Gaps = 83/775 (10%)

Query: 258  CVAELTEENFQRLHAEHERQAK-ELFLLRKTLEEMELRIETQKQTLNARDESIKKLL-EM 315
            CV +L +E    +    ++ +K EL  L   L+E +  +   K+   A  +  K+L  EM
Sbjct: 303  CVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEM 362

Query: 316  LQSKGLS------AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFE 369
            +  K  S       K      E+   + + ++HV + E+  +Q + +   +RE+M    E
Sbjct: 363  MTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQET--QQMQMKFQQVREQMEA--E 418

Query: 370  NAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY 429
             A    +   L+  +    +++ S +        E+  L+ + A    E  E+  +++  
Sbjct: 419  IAHLKQENGILRDAVSNTTNQLESKQSA------ELNKLRQDYARLVNELTEKTGKLQQE 472

Query: 430  RSHSKFMKNKVEQLKEELSSKEAQWEE----LKKKAAGLQAEIGQVKQELSRKDTELLAL 485
                K  +    QLK +L   E +WEE    ++K+ A  +A    ++ +   K+ E+ +L
Sbjct: 473  EVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSL 532

Query: 486  QTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQI 545
             +KL          +Q +  L ES   +  +   LQ +V  +   LE+ E  L  + +Q 
Sbjct: 533  HSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDI---LEQNEA-LKAQIQQF 588

Query: 546  QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSS-------LK 598
                  + + +    +L  ++  K++++   +  + + +++L  KE+++         LK
Sbjct: 589  HSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLK 648

Query: 599  ERVKSLQADTTNTDTA---LTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
              V+ LQA       A   L  +++++  K+  I  L+EQ   +   K EE        K
Sbjct: 649  AEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNK 708

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715
             LK +V  LQ  +SE+       K+    +     +KD +LKT+E  LE    +    E 
Sbjct: 709  ALKSEVQKLQTLVSEQPN-----KDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763

Query: 716  QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDK 775
            +L      A+    S  ++  +Q L+    +  D+ S A      L+E LK+V +EK+ K
Sbjct: 764  ELN-----AIRTENS-SLTKEVQDLK---AKQNDQVSFAS-----LVEELKKVIHEKDGK 809

Query: 776  DKKIAELER----QVKDQNKKVANLKHKEQVEKKKSAQM-LEEARRREDNLNDSSQQLQD 830
             K + EL      +V ++ K V +LK + +  K++   + LE+A++   ++    Q+LQ+
Sbjct: 810  IKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL--SITSKVQELQN 867

Query: 831  SLRKKDDRIEELEEALRESVQ-----------ITAEREMV------LAQEESARTNAEKQ 873
             L+ K++++  ++  L E  +           +  E E +      +AQ      ++  Q
Sbjct: 868  LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ 927

Query: 874  VEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLA 933
             EEL + +++ + EL+ ++A L   +  L+ K   L +++ E +    ++ ++KQ+    
Sbjct: 928  FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ 987

Query: 934  AISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYE 988
            A S    +  LL++ S ++K   E++ L  E D L   ++ Q +    L   N+E
Sbjct: 988  A-SSFPPHEELLKVISEREK---EISGLWNELDSLKDAVEHQRKKNNDLREKNWE 1038



 Score =  117 bits (294), Expect = 5e-26
 Identities = 159/720 (22%), Positives = 324/720 (45%), Gaps = 78/720 (10%)

Query: 414  LSTEEREEEMKQMEVYRSHSKF--MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQV 471
            + T E+E  + Q +++ S+ +   M+ K +Q++E++   EA+   LK++   L+  +   
Sbjct: 380  IGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---EAEIAHLKQENGILRDAVSNT 436

Query: 472  KQEL-SRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLR 530
              +L S++  EL  L+     L N+ ++    ++  +      EQ A  L+ ++     R
Sbjct: 437  TNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496

Query: 531  LEEKETMLNKKTKQI----QDMAEEKGTQAGEIHDLKDML--------DVKERKVNVLQK 578
             EE ++ + K+T +     QD+  +   +  E+  L   L         +++R + +++ 
Sbjct: 497  WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556

Query: 579  ------KIENLQEQLRDKEKQMSSLKERVKSLQ---ADTTNTDTALTTLEEALAEKERTI 629
                  K E+LQ Q++D  +Q  +LK +++      A  T+       L + +AEK++ I
Sbjct: 557  EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616

Query: 630  ER----LKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSL 685
            ++    L  +RDR    K+EE+ + +     LK +V  LQ   +E+ A+  +L++   S+
Sbjct: 617  KQTEDSLASERDR-LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSV 675

Query: 686  ASSGLKKDSRLKTLEIALEQ----KKEECLKMESQLK--KAHEAALEARASPEMSDRIQH 739
                  KD +++ LE  L+     K EE   +  Q K  K+    L+   S + +  +  
Sbjct: 676  ----YVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731

Query: 740  LEREITRYKDESSKAQAEVDRLLEI-LKEVENEKNDKDKKIAELERQVKDQNKKVANLKH 798
               +  + KDE  K    V+ LLE  L +V      K++++  +  +     K+V +LK 
Sbjct: 732  QMEKCIQEKDEKLKT---VEELLETGLIQVAT----KEEELNAIRTENSSLTKEVQDLKA 784

Query: 799  KEQVEKKKSAQMLEEARR---REDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAE 855
            K+  ++   A ++EE ++    +D    S ++L ++   K    E+  + L++ ++   E
Sbjct: 785  KQN-DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKE 843

Query: 856  REMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAE 915
                +  E++ + +   +V+EL   ++  ++++ +MKA L   ++ LA     L +L+ E
Sbjct: 844  EIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 903

Query: 916  R---RKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQ-- 970
                + H++EV +   +   +A   ++  I L E  +  K+ +   A LK  +  L    
Sbjct: 904  NESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLE---AMLKERESDLSSKT 960

Query: 971  QLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHL 1030
            QL Q  Q+  KL     E    K  +  Q +  P  +++++ + E ++  S L   +  L
Sbjct: 961  QLLQDVQDENKLFKSQIE--QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSL 1018

Query: 1031 -TTLCHDRDPLILRGLTPPASYNLDDDQAAWE-NELQKMTRGQLQDELEKGERDNAELQE 1088
               + H R              N D  +  WE  E    T   LQD++ K  ++  +  E
Sbjct: 1019 KDAVEHQR------------KKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1066



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 92/455 (20%), Positives = 189/455 (41%), Gaps = 66/455 (14%)

Query: 141  HSLRQARD-NTIMDLQTQLKEVLRENDLLRKDVEVKE--SKLSSSMNSIKT------FWS 191
            H+L++A   +   +L+  LKE  +EN+L R +  +KE  S LSS    ++        + 
Sbjct: 917  HNLKEASSASQFEELEIVLKE--KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFK 974

Query: 192  PELKKERALRKDEASKITIWKEQYRVVQEENQHMQ---MTIQALQDELRIQRDLNQLFQQ 248
             ++++ +     +AS     +E  +V+ E  + +      + +L+D +  QR  N     
Sbjct: 975  SQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNN---- 1030

Query: 249  DSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES 308
                        +L E+N++ + A    +      + KT +E + ++E  +  L A+ E 
Sbjct: 1031 ------------DLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE--LEAK-EV 1075

Query: 309  IKKL---------------LEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQK 353
            +KKL               L   + K     A     E  + L         + +LL+ +
Sbjct: 1076 LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLE 1135

Query: 354  -EKENSMLRE------EMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQ 406
             EK  S+L E      ++ R  E   +  K K     ++     I  M+      E+E++
Sbjct: 1136 CEKYKSVLAETEGILQKLQRSVEQEENKWKVK-----VDESHKTIKQMQSSFTSSEQELE 1190

Query: 407  MLKS-NGALSTEEREEEMKQMEVYRSHSKFMK--NKVEQLKEELSSKEAQWEELKKKAAG 463
             L+S N  +    RE E  +ME+ ++  +      +V +LK+ L+  + + ++   +A  
Sbjct: 1191 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250

Query: 464  LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
               E+  +K +L+   T+L   Q + + +      ++Q +E+++  +        +++  
Sbjct: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310

Query: 524  VDALRLRLEEKETM---LNKKTKQIQDMAEEKGTQ 555
              +      EKETM   LN+   Q+Q + +    Q
Sbjct: 1311 DVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345



 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 127/635 (20%), Positives = 247/635 (38%), Gaps = 112/635 (17%)

Query: 504  EVLKESLTAKEQRAA-ILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDL 562
            E L + + AK++R   ++ T+ D  + + E+K+    KK  Q  ++ E           L
Sbjct: 31   ETLYDEVLAKQKREQKLIPTKTD--KKKAEKKKN--KKKEIQNGNLHESDSESVPRDFKL 86

Query: 563  KDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEAL 622
             D L V++ +V  +   +      +R+++K+    +++ K +  +    ++  + +    
Sbjct: 87   SDALAVEDDQVAPVPLNVVETSSSVRERKKK----EKKQKPVLEEQVIKESDASKIPGKK 142

Query: 623  AEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
             E     ++     +    +K+      K    D  +KV  L      +EA  L L +  
Sbjct: 143  VEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEA--LPLHQET 200

Query: 683  SSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAAL--EARASPEMS------ 734
               + SG KK S  K       QK E     E  +       L   A +SP +       
Sbjct: 201  KQESGSGKKKASSKK-------QKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVID 253

Query: 735  ----DRIQHLEREITR-YKDESSKAQAEV---DRLL----------------EILKEVEN 770
                D+++ +++  T+  K E+ K  AEV   D LL                ++LKE   
Sbjct: 254  LLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSG 313

Query: 771  EKNDKDKK-----IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSS 825
               D  KK     +  L  Q+++++K +A +K      K +  Q+ +E    ++  N   
Sbjct: 314  VIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVI 373

Query: 826  QQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVK 885
             +++D +   +      +  +  S Q T + +M   Q    R   E ++  L       K
Sbjct: 374  TRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQ---VREQMEAEIAHL-------K 423

Query: 886  QELESMKAKLSSTQQSLAEKET-HLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
            QE   ++  +S+T   L  K++  L  LR +  + + E+ E   +     + +K+A  A 
Sbjct: 424  QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA 483

Query: 945  LELSSSKKKTQ---EEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTN 1001
             +L    ++ +   EEV +  R++    +  +Q  Q++        +++  +S HS  T+
Sbjct: 484  TQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVA-----KENEVQSLHSKLTD 538

Query: 1002 HKPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWE 1061
               S  Q+ Q L++L ++  K                                  +   E
Sbjct: 539  TLVSKQQLEQRLMQLMESEQK----------------------------------RVNKE 564

Query: 1062 NELQKMTRGQLQDELEKGERDNAELQEFANAILQQ 1096
              LQ     Q+QD LE+ E   A++Q+F + I  Q
Sbjct: 565  ESLQM----QVQDILEQNEALKAQIQQFHSQIAAQ 595


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score =  142 bits (358), Expect = 2e-33
 Identities = 215/941 (22%), Positives = 405/941 (43%), Gaps = 139/941 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSP-ELKKERALRKDEA---- 205
            I +LQ ++KE   EN  L   +E ++ K+ S +N +K   S   L++ + + K EA    
Sbjct: 1769 IHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIEL 1828

Query: 206  -SKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPC---VAE 261
               +   K++   + E+ ++     Q L   +     LN   +  +   + E     VA+
Sbjct: 1829 EKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAK 1888

Query: 262  LT----------EENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKK 311
            +           E    R+ +E      E   L   LE     ++T+K  L   +E+ +K
Sbjct: 1889 VNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEV----VQTEKLCLEKDNENKQK 1944

Query: 312  LLEMLQSKGLSAKATEEDHERTR--RLAEAEMHVHHLESLLEQKEKE-NSMLREEMHR-R 367
            ++  L+ + LS   +E +  R     +++    +  L   +++K +E  S   E +H  +
Sbjct: 1945 VIVCLEEE-LSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQ 2003

Query: 368  FENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQML-KSNGALSTEEREEEMKQM 426
               A    KT+ LQT+     S +S + +    L+E++Q L K + ALS  + E E  Q+
Sbjct: 2004 VAEAEVKEKTELLQTL----SSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELE-NQI 2058

Query: 427  EVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQ 486
                   + +  + E L+  LS  + +   + K       E G+    LS    E+  L+
Sbjct: 2059 AQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLR 2118

Query: 487  TKLETLTNQF-SDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQI 545
              +E L  +  +D K+ + +  E L  +E+    L+ +V+ L   L+  E          
Sbjct: 2119 RGIEKLRVRIEADEKKQLHIA-EKLKERERENDSLKDKVENLERELQMSEENQELVILDA 2177

Query: 546  QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQ 605
            ++   E  T   +I ++   L V E  +  L+ + ENL +Q+++K+ Q+S L        
Sbjct: 2178 ENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL-------- 2229

Query: 606  ADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQ 665
                  D  L++ +  L EKE+   ++KE       E +  ++  +  LK+L E V+ L 
Sbjct: 2230 ------DKLLSSFKSLLEEKEQAEIQIKE-------ESKTAVEMLQNQLKELNEAVAALC 2276

Query: 666  GD---LSEKEASLLDLKEHASSLASSGLKKDSRLKTLE----IALEQKKE---------- 708
            GD   +   E SL    E    L +S  K  +RL+  E      L+Q KE          
Sbjct: 2277 GDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKG 2336

Query: 709  --ECLKMESQLKKAHE--AALEARAS-----------PEMSDRIQHLEREITRYKDE--- 750
              E L+ E ++ + ++  AALEA  S             M+  ++ LE ++   + E   
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396

Query: 751  -SSKAQAEVDRLLE----------ILKEVENEKNDKDKK----IAELERQVKDQNKKVAN 795
             +++ Q E +R+ E          IL+E E EK    +K    +  L+ Q+K+ N++VA 
Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456

Query: 796  L-------KHKEQ----------VEKKKSAQMLEEARRR----EDNLNDSSQQLQD---S 831
            L       K KEQ          +EK +  Q L+EA+      + ++N   Q+++D    
Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQK 2516

Query: 832  LRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESM 891
            L KKD+ I  L+  +++  Q+ ++    L+Q E      ++Q  EL     +++Q+++ +
Sbjct: 2517 LEKKDEEISRLKNQIQDQEQLVSK----LSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 2572

Query: 892  KAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSK 951
            ++K +S Q +L   ++   NL  E      + +   ++       E +    + E++   
Sbjct: 2573 QSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKT 2632

Query: 952  KKTQEEVAALKR----EKDRLVQQLKQQTQNRMKLMADNYE 988
             + QEE++  K     E   L++++K       +L  +N E
Sbjct: 2633 AELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSE 2673



 Score =  139 bits (349), Expect = 2e-32
 Identities = 176/857 (20%), Positives = 365/857 (42%), Gaps = 70/857 (8%)

Query: 224  HMQMTIQALQDELRIQ-RDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELF 282
            H+   ++A   ELR +  +L    Q       G+    +  +   ++   E   + K L 
Sbjct: 278  HLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337

Query: 283  LLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMH 342
              R  L     + +       A ++ +KKL E L  +  +A++     E+  +  E E  
Sbjct: 338  KCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQ 397

Query: 343  VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLE 402
                E L  Q+    ++ +E +  +     +  + K +  V++ +  K++S+++ L +  
Sbjct: 398  ----EELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNL 453

Query: 403  EEIQ--MLKSNGALSTEE-REEEMKQ-MEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK 458
            EE +  + ++  A    + +E E+++ ME  +  +  +K+  EQ   E+   EA+ + +K
Sbjct: 454  EEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIK 513

Query: 459  KKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEV--LKESLTAKEQR 516
            +     Q    ++K + + ++T L  LQ K+    N  +  K  + V  L++     +  
Sbjct: 514  QCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDL 573

Query: 517  AAILQTEVDALRLRLEEKE-------TMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
                +  ++ L  +L + E       + L  K K+ +++ EEK   +    + + +L   
Sbjct: 574  LKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQM 633

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
            E +   LQ KI +L+  L+ ++ +     ERV++L+ D  N    +  L   L  K   +
Sbjct: 634  ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEV 693

Query: 630  E-------RLKEQRDRDEREKQEEIDNY-------KKDLKDLKEKVSLLQGDLSEKEASL 675
            E        L+++ +  +++ Q+EI+N           ++DL+ K+ LL  ++ +K+   
Sbjct: 694  ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCY 753

Query: 676  LDLKEHASSLASSGLKKDSRLKTLE------IALEQK-------KEECLKMESQLKKAHE 722
             DL     SL      KD+ L T E      +A +Q+            +  S   +  E
Sbjct: 754  QDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSE 813

Query: 723  AALEARASPE----MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKK 778
              LEA  SP+    + +R+  LE  +   K  +S  Q + + L++I  E+E      ++ 
Sbjct: 814  CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873

Query: 779  IAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDN---LNDSSQQLQDSLRKK 835
                   V + +++++ L+      +   A+ L     +E     LND  +  Q  +++ 
Sbjct: 874  HQSF---VAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQEL 930

Query: 836  DDRIEELEEALRESVQITAEREMVLAQEESARTNAEK-QVEELLMAMEKVKQELESMKAK 894
                  LE++L+E +Q+ +E   +  +E S+  +  K ++EEL      +K+    + A 
Sbjct: 931  KKSNHLLEDSLKE-LQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKE----INAS 985

Query: 895  LSSTQQSLAEKETHLTNLRAERRKHLEEVLEM-KQEALLAAISEKDANIALLELSSSKKK 953
            L+  + +L +K     N   ER K + E+ +  KQE L+     ++   A  +LS   K 
Sbjct: 986  LNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKA 1045

Query: 954  TQE---EVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHK-----PS 1005
             QE   ++  L  E   L +  K + +   +  A  +++   K + + + N        +
Sbjct: 1046 AQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELET 1105

Query: 1006 PDQIIQPLLELDQNRSK 1022
              Q ++  +  +QN SK
Sbjct: 1106 VQQALRSEMTDNQNNSK 1122



 Score =  138 bits (348), Expect = 3e-32
 Identities = 192/934 (20%), Positives = 411/934 (44%), Gaps = 124/934 (13%)

Query: 259  VAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDES---IKKLLEM 315
            V E + EN + LH   +R  K   LL + ++E++ ++  Q+  L  + E+   ++K++  
Sbjct: 1776 VKETSNENLRLLHVIEDRDRKVESLLNE-MKELDSKLHLQEVQLMTKIEACIELEKIVGE 1834

Query: 316  LQSKGLSAKATEE----DHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENA 371
            L+ +        E    DH+   +  E       L S LE    ++S  RE++       
Sbjct: 1835 LKKENSDLSEKLEYFSCDHQELLQRVETS---EGLNSDLEMHADKSS--REDIGDNVAKV 1889

Query: 372  PDSAKTKALQTVIEMKD--SKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMK----- 424
             DS K + L    E+    S+ +S+E     LE +++++++      ++ E + K     
Sbjct: 1890 NDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCL 1949

Query: 425  --QMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTEL 482
              ++ V  S    ++ +++ + ++ ++ +   E++K+K   L++   +    +   + E+
Sbjct: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009

Query: 483  LALQTKLETLTNQFSD---SKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
                  L+TL++  S+    K H++   +SL    Q  ++ + E++    +L +++ +L 
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLV 2069

Query: 540  KKTKQIQDMAEE---------KGTQAG----------------EIHDLKDMLDVKERKVN 574
            K+++ +Q    E         K  +A                 E+H L+  ++    ++ 
Sbjct: 2070 KESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIE 2129

Query: 575  VLQKKIENLQEQLRDKEKQMSSLKERVKSL----QADTTNTDTALTTLEEALAEKERTIE 630
              +KK  ++ E+L+++E++  SLK++V++L    Q    N +  +   E + AE    +E
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAE----VE 2185

Query: 631  RLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGL 690
             LK Q +    E    +  ++ DL  L+ +   L   + EK+  L +L +  SS  S   
Sbjct: 2186 TLKTQIE----EMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLE 2241

Query: 691  KKDSRLKTLEIALEQKKEECLKM-ESQLKKAHEAALEARASPEMSDRIQHL------ERE 743
            +K+      EI ++++ +  ++M ++QLK+ +EA        E+    +        E  
Sbjct: 2242 EKEQA----EIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEH 2297

Query: 744  ITRYKDESSKAQAEVDR-----LLEILKEVENEKNDKDKKIAELERQVKDQNK------- 791
              R   E  +A+ E D      +L+ LKE E+  +    ++  LER+++           
Sbjct: 2298 QLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAAL 2357

Query: 792  KVANLKHKEQVEKKKSAQMLEEARRREDN---LNDSSQQLQDSLRKKDDRIEELEEALRE 848
            +  N K + +  K K   M +  R  E +   +    + L + L+K+ +RI ELE     
Sbjct: 2358 EAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI---- 2413

Query: 849  SVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETH 908
               I +  E +L ++E  +   +++    +  ++   +EL    A L + Q++   KE +
Sbjct: 2414 ---INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQN 2470

Query: 909  LTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREK-DR 967
            L++          E LE+++  LL  + E   N  +L+ S +    + E    K EK D 
Sbjct: 2471 LSSQ--------VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDE 2522

Query: 968  LVQQLKQQTQNRMKLMA--DNYEDDH--FKSSHSNQTNHKPSPDQIIQPLLELDQN-RSK 1022
             + +LK Q Q++ +L++     E +H  +K  +    N     +Q IQ L   + + +  
Sbjct: 2523 EISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDT 2582

Query: 1023 LKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMT--RGQLQDELEKGE 1080
            L++       L ++ +   +             D+ ++  ++ KMT    +LQ E+ +  
Sbjct: 2583 LEVLQSSYKNLENELELTKM-------------DKMSFVEKVNKMTAKETELQREMHEMA 2629

Query: 1081 RDNAELQEFANAILQQIADHCPDILEQVVNALEE 1114
            +  AELQE  +    ++A     +LE++ ++ ++
Sbjct: 2630 QKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663



 Score =  129 bits (325), Expect = 1e-29
 Identities = 200/992 (20%), Positives = 408/992 (41%), Gaps = 140/992 (14%)

Query: 151  IMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITI 210
            I  L+ +LK    E +  ++  +  +  L+      K F +P    +        SK   
Sbjct: 111  IEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYY----SGSKYED 166

Query: 211  WKEQYRVVQEENQHMQMTIQALQDELRIQ---------RDLNQLFQQDSSSRTGEPCVAE 261
             KE+Y    EE + ++  ++ALQ +   Q         RD+ +     S     +     
Sbjct: 167  LKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPS 226

Query: 262  LTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNAR---DESIKKLLEML-- 316
                N QR     +  A   F   + +      ++  K+  N+    + S   LL+ L  
Sbjct: 227  HLSSNSQRTPIRRDFSA-SYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285

Query: 317  QSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAK 376
            Q++ L  K  E +        E +  V+  + L  Q EK    L E+     E   +  +
Sbjct: 286  QNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEK-----EKVLNKCR 340

Query: 377  TKALQTV--IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSK 434
             + ++T    +   +K +++E+ L+ L E++   + N   +    E+++K+ E       
Sbjct: 341  DELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKE------- 393

Query: 435  FMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTN 494
                  ++ +EELS ++  ++ L ++   ++A   ++ QEL +       LQ +L+ LT+
Sbjct: 394  ------KEFQEELSRQQRSFQTLDQECIQMKA---RLTQELQQAKNMHNVLQAELDKLTS 444

Query: 495  QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT 554
                 + ++E  K+ L   EQ     Q + + LR  +EE +   N      +  A E   
Sbjct: 445  VKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCH 504

Query: 555  QAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE--RVKSLQADTTNTD 612
               E+ ++K  L+  +     ++ K  + +  LRD +++++  +    ++ L+    + +
Sbjct: 505  LEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLE 564

Query: 613  TALTTLEEALAEKERTIERLKEQRDRDEREKQ---EEIDNYKKDLKDLKEKVSLLQGDLS 669
                  ++ L ++E  IE+L ++  + E+E +     ++  KK+ ++LKE+ +L     S
Sbjct: 565  KQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKS 624

Query: 670  EKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES-------QLKKAHE 722
            E E  L  ++    +L S     ++ LKT +I   +  E    +E        +++  H 
Sbjct: 625  ENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684

Query: 723  --------------AALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
                          A +E +   E SD  Q  ++EI     ++S+   +V+ L   L+ +
Sbjct: 685  VLDSKSVEVETQKLAYMELQQKAEFSD--QKHQKEIENMCLKTSQLTGQVEDLEHKLQLL 742

Query: 769  ENEKNDKDKKIAELERQ---VKDQNKK-----VANLKHKE-------------------- 800
             NE  DKD+   +L  +   ++D  K      V N  H+                     
Sbjct: 743  SNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIG 802

Query: 801  ------------QVEKKKSAQMLEEARRREDNLN---DSSQQLQDSLRKKDDRI----EE 841
                        ++E  +S +     + R D+L    +S +Q+   L+K+ + +     E
Sbjct: 803  EQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGE 862

Query: 842  LEEALRESVQI-------TAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAK 894
            +EE L ++ Q+       T++R   L ++ SA  N    V E L A+E  ++EL+ +  K
Sbjct: 863  IEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNV---VAETLSALENKEKELQLLNDK 919

Query: 895  LSSTQQSLAE--KETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKK 952
            + + Q  + E  K  HL     +  + L E L ++++ + + IS     I   EL+    
Sbjct: 920  VETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIE--ELTQENG 977

Query: 953  KTQEEVAALKREKDRLVQQLK------QQTQNRMKLMADNYEDDH-FKSSHSNQTNHKPS 1005
              +E  A+L +EK  L+Q+ +       + +  +  ++D Y+ +         +T +  +
Sbjct: 978  TLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGN--A 1035

Query: 1006 PDQIIQPLLELDQNRSKLKLYIGHLTTLCHDR 1037
             + + Q      +  SKL+  +   T+LC +R
Sbjct: 1036 YEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067



 Score =  124 bits (312), Expect = 4e-28
 Identities = 164/801 (20%), Positives = 338/801 (42%), Gaps = 83/801 (10%)

Query: 145  QARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFW------SPELKKER 198
            +A +   + +  +LKE  REND L+  VE  E +L  S  + +           E++  +
Sbjct: 2129 EADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLK 2188

Query: 199  ALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLF--------QQDS 250
               ++ A  + +++     ++ E +++   IQ  Q +L     L   F        Q + 
Sbjct: 2189 TQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEI 2248

Query: 251  SSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIK 310
              +       E+ +   + L+        +  +++ T + ++  IE + Q  N+  E ++
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSI-EKLR 2307

Query: 311  KLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFEN 370
              LE  + K L            ++L E+E H   L+  +E  E+E  + R         
Sbjct: 2308 ARLEADEKKQLCV---------LQQLKESEHHADLLKGRVENLERELEIARTNQEHAALE 2358

Query: 371  APDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEEMKQME 427
            A +S      +  +E   +KI  M + LR LE ++  ++S     T E    +E + ++E
Sbjct: 2359 AENS------KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELE 2412

Query: 428  VYRSHSKFMKNKVEQLKEELSSK--------EAQWEELKKKAAGLQAEIGQVKQELSRKD 479
            +  S  + +  + EQ K ++  K        + Q +EL ++ A L  +    K +     
Sbjct: 2413 IINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLS 2472

Query: 480  TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 539
            +++  L+ +   L     ++K +  VL+ S+    Q       EV+  + +LE+K+  ++
Sbjct: 2473 SQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ-------EVEDGKQKLEKKDEEIS 2525

Query: 540  KKTKQIQDMAE--EKGTQAGEIH--------DLKDMLDVKERKVNVLQKKIENLQEQLRD 589
            +   QIQD  +   K +Q    H        +L+++    E+K+ VLQ K  +LQ+ L  
Sbjct: 2526 RLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEV 2585

Query: 590  KEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDN 649
             +    +L+  ++  + D  +    +  +     E +R +  + ++    + E   E + 
Sbjct: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645

Query: 650  YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEE 709
               +L+ L E++   +  L E      +LK+    +    ++K+ +++      E+  E 
Sbjct: 2646 LAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVR------EEIAEY 2699

Query: 710  CLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVE 769
             L++    KK     L+     E+   IQ    ++T  ++  S  + E+D L    +E+ 
Sbjct: 2700 QLRLHEAEKKHQALLLDTNKQYEV--EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELN 2757

Query: 770  NEKNDKDKKIAELERQVKDQNKKVANL-KHKEQVEKK-----KSAQMLEEAR---RREDN 820
            N      + + EL++   D  K V  L K  E+ + K     KS + LEE +   ++E +
Sbjct: 2758 NSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELS 2817

Query: 821  LNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM- 879
               ++Q+ Q +    D +++EL   ++E       +E +  + + A    +K    L+  
Sbjct: 2818 QLQAAQEKQKTGTVMDTKVDELTTEIKEL------KETLEEKTKEADEYLDKYCSLLISH 2871

Query: 880  -AMEKVKQELESMKAKLSSTQ 899
              +EK K+ LE+  A L S Q
Sbjct: 2872 EKLEKAKEMLETQVAHLCSQQ 2892



 Score =  100 bits (249), Expect = 8e-21
 Identities = 145/735 (19%), Positives = 297/735 (40%), Gaps = 75/735 (10%)

Query: 291 MELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLL 350
           M   +E  K+ L  R  +++K+ E+   +G   K  +E  +R  +L   E  +   +  +
Sbjct: 1   MSWALEEWKEGLPTR--ALQKIQEL---EGQLDKLKKEKQQRQFQLDSLEAALQKQKQKV 55

Query: 351 EQKEKENSMLREEMHRRFENAPDSAKTK--------ALQTVIEMKDSKISSMERGLRDLE 402
           E ++ E + L+ E  R  E      KTK          ++ +  ++ +++S ++ +  LE
Sbjct: 56  ENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLE 115

Query: 403 EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAA 462
           +E++  KS    S +  +     +    +  K     +   +    SK   +E+LK+K  
Sbjct: 116 QELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSK---YEDLKEK-- 170

Query: 463 GLQAEIGQVKQELSRKDTELLALQTK-----LETLTNQFSDSKQHIEVLKESLTAKEQRA 517
                  +  +E  R + E+ ALQ K     L   T    D  +H          +E+  
Sbjct: 171 -----YNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225

Query: 518 AILQTEVDALRLRLE--------EKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
           + L +      +R +        E+E   ++ T QI     +  +   +      +LD  
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGK--RDANSSFFDNSSSPHLLDQL 283

Query: 570 ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
           + +   L+ KI  L+ +L+  EK+M     + + LQ         L   +  L EKE+ +
Sbjct: 284 KAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQ-------LEKAKVELIEKEKVL 336

Query: 630 ERLKEQRDRDEREKQEEIDNY---KKDLKDLKEKVSLLQGDLSEKEASLLD-LKEHASSL 685
            + +++  R   +  +    Y   ++ LK L E +S  + +      SL   +KE     
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEF 396

Query: 686 ASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAH---EAALEARAS--PEMSDRIQHL 740
                ++    +TL+    Q K    +   Q K  H   +A L+   S   ++ + ++  
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEF 456

Query: 741 EREITRYKDESSKAQAEVDRLLEILKEVENEKN-------DKDKKIAELERQVKDQNKKV 793
           ++++ R +     +Q + + L   ++E++ E N        K +++  LE ++K+  + +
Sbjct: 457 KQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCL 516

Query: 794 ANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQIT 853
              ++  +  K K+       R  ++ +N     L  +L K    + +LE+    S  + 
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSL--TLEKLKLAVADLEKQRDCSQDLL 574

Query: 854 AEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLR 913
            +RE  + Q     +  EK+ + LL A+E  K+E E +K + +      +E E  LT + 
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQME 634

Query: 914 AERR------KHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDR 967
           +E+        HLE  L+ +Q      I   + N  +  L   ++    E+  L    D 
Sbjct: 635 SEKENLQSKINHLETCLKTQQ------IKSHEYNERVRTLEMDRENLSVEIRNLHNVLDS 688

Query: 968 LVQQLKQQTQNRMKL 982
              +++ Q    M+L
Sbjct: 689 KSVEVETQKLAYMEL 703



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 132/555 (23%), Positives = 238/555 (42%), Gaps = 97/555 (17%)

Query: 147  RDNTIMD-LQTQLKEVLRENDLLRKDVEV---KESKLSSSMNSIKTFWSPELKKERALRK 202
            + +T M+ LQTQLKE+      L  D E    KE  LSS +  +      EL+K + L+ 
Sbjct: 2435 KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECL------ELEKAQLLQG 2488

Query: 203  -DEASKITIWKEQYRVVQEENQHMQMTIQALQD-ELRIQRDLNQLFQQDSSSRTGEPCVA 260
             DEA      K  Y V+Q     +   IQ ++D + ++++   ++ +  +  +  E  V+
Sbjct: 2489 LDEA------KNNYIVLQSSVNGL---IQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVS 2539

Query: 261  ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKG 320
            +L++     +  EH+   ++   LR    E+E +I    Q L +++ S++  LE+LQS  
Sbjct: 2540 KLSQ-----VEGEHQLWKEQNLELRNLTVELEQKI----QVLQSKNASLQDTLEVLQS-- 2588

Query: 321  LSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKAL 380
             S K  E + E T+               +   EK N M  +E   + E    + KT  L
Sbjct: 2589 -SYKNLENELELTKM------------DKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635

Query: 381  QTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKV 440
            Q  +  + ++++     L+ L EEI+  K      T E  E  K ++         + KV
Sbjct: 2636 QEELSGEKNRLAGE---LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKV 2692

Query: 441  EQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 500
               +EE++  + +  E +KK   L  +  +               Q ++E          
Sbjct: 2693 ---REEIAEYQLRLHEAEKKHQALLLDTNK---------------QYEVE---------- 2724

Query: 501  QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
              I+  +E LT+KE+  +  + E+D L+   EE    L   T+ ++++ + K      ++
Sbjct: 2725 --IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVN 2782

Query: 561  DLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEE 620
             LK   +  + K+ +L K  + L+E+    +K++S L +  +  Q   T  DT +  L  
Sbjct: 2783 QLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQL-QAAQEKQKTGTVMDTKVDELTT 2841

Query: 621  ALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
             + E + T+E           EK +E D Y      L     L+  +  EK   +L+ + 
Sbjct: 2842 EIKELKETLE-----------EKTKEADEYLDKYCSL-----LISHEKLEKAKEMLETQ- 2884

Query: 681  HASSLASSGLKKDSR 695
              + L S   K+DSR
Sbjct: 2885 -VAHLCSQQSKQDSR 2898



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 162/890 (18%), Positives = 340/890 (38%), Gaps = 141/890 (15%)

Query: 153  DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
            DLQ Q +E+++    ++ ++E    K      S     S  + K   L++D ++   +  
Sbjct: 848  DLQKQCEELVQ----IKGEIEENLMKAEQMHQSFVAETSQRISK---LQEDTSAHQNVVA 900

Query: 213  EQYRVVQEENQHMQMT---IQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
            E    ++ + + +Q+    ++  Q E++  +  N L +              L ++    
Sbjct: 901  ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960

Query: 270  LHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEED 329
            + + ++R+ +EL     TL+E+   +  +K  L  + ES    ++               
Sbjct: 961  IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID--------------- 1005

Query: 330  HERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDS 389
             ER + ++E        + +L Q+ +E     E++ ++++ A +  K   L+ ++    S
Sbjct: 1006 -EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE--KNSKLECLLNECTS 1062

Query: 390  KISSMERGLRDLEE----EIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKE 445
               + +  L  L+E    E Q   +  A + E  +  M ++E  +          + L+ 
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ----------QALRS 1112

Query: 446  ELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQ---- 501
            E++  +      K +A GL+ EI  +K+E ++   E+  L  + E L        +    
Sbjct: 1113 EMTDNQ---NNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNL 1169

Query: 502  HIEVLKESLTAKEQRA-----------AILQTEVDALRLRLEEKETMLNKKTKQIQDMAE 550
              E ++ S+  +E               + +  +D+   +L + E ML  K  ++Q+  +
Sbjct: 1170 ESEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEK 1229

Query: 551  EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTN 610
            EK     E+  ++  L+    + ++  ++I  L++   D E++  S    + + Q D  +
Sbjct: 1230 EKECLQHELQTIRGDLETSNLQ-DMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAH 1288

Query: 611  TDTALTTLEEALAEKERTIERLKEQR---------DRDE-----REKQEEIDNYKKDLKD 656
               +L T    L E E+  E L+ ++          R E     R+  EE+     ++K 
Sbjct: 1289 LQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKI 1348

Query: 657  LKEKVSLLQGDL-----------------------------------SEKEASL------ 675
            L +   LL G+L                                   S+KE  +      
Sbjct: 1349 LNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQ 1408

Query: 676  ---LDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK-------KAHEAAL 725
               L L+     L     +  S++  L+  ++  K E L + + L+       K  +  L
Sbjct: 1409 EKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGL 1468

Query: 726  EARASPEMSDRIQHLEREITRYKDESS-KAQAEVDRLLEILKEVENEKNDKDKKIAEL-- 782
            E    P +S         ++   D S  +A  E    + +L  +E   +     + E+  
Sbjct: 1469 EEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFC 1528

Query: 783  ----ERQVKDQNKKVANLKHKEQVEK-----KKSAQMLEEARRREDNL-NDSSQQLQDSL 832
                E  +  +    A  K  E++E      ++S + LEE    +  + N   Q+L+  L
Sbjct: 1529 SSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLL 1588

Query: 833  RKKDDRIEEL-EEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESM 891
              +   ++ L ++ L E+ Q   +   V  + ES     +KQ E+L + +E  + +L+ +
Sbjct: 1589 SSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGL 1648

Query: 892  KAKLSSTQQSLAEKETHLTNLRAE-RRKHLEEVLEMKQEALLAAISEKDA 940
                 S      E      N   +  ++H  E  E   +  +  I +KDA
Sbjct: 1649 DLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDA 1698



 Score = 84.3 bits (207), Expect = 6e-16
 Identities = 176/842 (20%), Positives = 340/842 (40%), Gaps = 141/842 (16%)

Query: 273  EHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE--------MLQSKGLSAK 324
            E ++  K   +L+  ++ +E  +E+QKQ  +   +  ++L++        +++++ +   
Sbjct: 817  EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQS 876

Query: 325  ATEEDHERTRRLAE-AEMH---VHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT--- 377
               E  +R  +L E    H   V    S LE KEKE  +L +++        +  K+   
Sbjct: 877  FVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHL 936

Query: 378  -----KALQTVIEM----KDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
                 K LQ + E     K    S +    R++EE   + + NG L         ++M +
Sbjct: 937  LEDSLKELQLLSETLSLEKKEMSSIISLNKREIEE---LTQENGTLKEINASLNQEKMNL 993

Query: 429  YRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTK 488
             +    F  N +++ ++ +S    Q+++ K        E G   ++LS+K        +K
Sbjct: 994  IQKSESFA-NYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSK 1052

Query: 489  LETLTNQFS----DSKQHIEVLKESLTAKEQ----RAAILQTEVDALRLRLEEKETMLNK 540
            LE L N+ +    + K  +E LKE+   + Q    + A  +     L L LE  +  L  
Sbjct: 1053 LECLLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRS 1112

Query: 541  KTKQIQDMAE-EKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDK--------E 591
            +    Q+ ++ E G    EI  LK+  +  +++VN L ++ E L + ++ K        E
Sbjct: 1113 EMTDNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESE 1172

Query: 592  KQMSSLKER----------------VKSLQADTTNTDTALTTLEEALAEKERTIERLKEQ 635
               +S+KER                VK +  D+ N    L  LE  L  KE     LK Q
Sbjct: 1173 PIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQ--LVQLEAMLRNKE-----LKLQ 1225

Query: 636  RDRDERE-KQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
                E+E  Q E+   + DL     + S LQ   S++ + L D +  A     SG  + S
Sbjct: 1226 ESEKEKECLQHELQTIRGDL-----ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELS 1280

Query: 695  ------------------RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDR 736
                              +L  LE   E  + E  ++ ++L  +    +   A+ +M++ 
Sbjct: 1281 TSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECI--TATRKMAEE 1338

Query: 737  IQHLEREITRYKDESSKAQAEVDRLLEILK-----EVENEKN-------DKDKKI----- 779
            +  L  E+    D+S     E   L+E +      E  NE++       D+         
Sbjct: 1339 VGKLLNEVKILNDDSGLLHGE---LVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTL 1395

Query: 780  --AELERQVKDQNKKVANLKHKEQVEKKKSAQM---LEEARRREDNLNDSSQQLQDSLRK 834
               E++    +  +K  +L+ + ++   +  QM   + E +   D+L   +  L  +LR 
Sbjct: 1396 SDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRN 1455

Query: 835  -KDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKA 893
             + D ++E++  L E + + +     +    S  +  +      L+        L +++ 
Sbjct: 1456 FQGDLVKEMQLGLEEGL-VPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEG 1514

Query: 894  KLSSTQQSLAE------KETHLT-----NLRAERRKHLEEVLEMKQEALLAAISEKDANI 942
             +S+ Q S+ E      +E +LT     +  A+  + LE + E+ +++ L  + EK  + 
Sbjct: 1515 AVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQS-LEKLEEKMESQ 1573

Query: 943  ALLELSSSKKKTQEEVAALKREKDRL----VQQLKQQTQNRMKLMADNYEDDHFKSSHSN 998
             +++     K+ QE    L  E+  L     Q L +  Q + KL +   E +   ++   
Sbjct: 1574 GIMK----NKEIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKK 1629

Query: 999  QT 1000
            QT
Sbjct: 1630 QT 1631


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score =  141 bits (356), Expect = 3e-33
 Identities = 221/971 (22%), Positives = 417/971 (42%), Gaps = 195/971 (20%)

Query: 159  KEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEA------------S 206
            K+ L +++  RK++E K   L    N ++     + + E  L  +E             +
Sbjct: 861  KDELAKSEAKRKELEEKLVTLVQEKNDLQL--QVQAESENLLDAEERCDQLIKAKFQLEA 918

Query: 207  KITIWKEQYRVVQEENQHMQMTIQALQDEL-RIQRDLNQL----FQQDSSSRTGEPCVAE 261
            KI    E+    +E N  +    + L+DE   +++D++ L     + +      E  V  
Sbjct: 919  KIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKN 978

Query: 262  LTEE--NFQRLHAEHERQAKELFLL-RKTLEEMELRIETQKQTLNARDESIKKLLEMLQS 318
            LTEE        A+  R+ K L    ++ L++++   E +  +LN     +++ +E L+S
Sbjct: 979  LTEELSGLDETIAKLTREKKALQEAHQQALDDLQAE-EDKVNSLNKTKSKLEQQVEDLES 1037

Query: 319  KGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRR-FENAPDSAKT 377
                 K    D ER +R  E ++ +   ES+L+  E +   L E + ++ FE     +K 
Sbjct: 1038 SLEQEKKLRVDLERNKRKLEGDLKLAQ-ESILDL-ENDKQQLDERLKKKDFEYCQLQSKV 1095

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY-------- 429
            +  QT+      KI  ++  + +LEEEI+  ++  A + ++R +  +++E          
Sbjct: 1096 EDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG 1155

Query: 430  -----------RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQ-------V 471
                       +  ++F+K +   L+E     EA    L+KK A   AE+G+       V
Sbjct: 1156 GVTSTQIELNKKREAEFLKLR-RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRV 1214

Query: 472  KQELSRKDTELLA------------------LQTKLETLTNQFSDSKQHIEVLKESLTAK 513
            KQ+L ++ +E                     L+    TL +Q S+++   E ++ SL+  
Sbjct: 1215 KQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSEL 1274

Query: 514  EQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKV 573
              + + LQTE   L  +LEEKE+++++ ++  Q   ++         +LK  L+ + +  
Sbjct: 1275 TTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQT-------EELKRQLEEENKAK 1327

Query: 574  NVLQKKIEN-------LQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKE 626
            N L   +++       L+EQ  ++++  + L+  +    ++     T   T  +A+   E
Sbjct: 1328 NALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYET--DAIQRTE 1385

Query: 627  RTIERLKE--QRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASS 684
               E  K+  QR +D  E+ E ++     L+  K++   LQG++   E  ++D+ E A+S
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQR---LQGEV---EDLMVDV-ERANS 1438

Query: 685  LASSGLKKDSRLKTLEIALEQKKEECLKMESQL-----------------KKAHEAALEA 727
            LA++    D + +  +  L + K +C + +++L                 K A+E AL+ 
Sbjct: 1439 LAAA---LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQ 1495

Query: 728  -----RASPEMSDRIQHLEREI-----TRYKDESSKAQAEVDR----------------- 760
                 R +  +   I  L  +I     T ++ E S+ Q E+++                 
Sbjct: 1496 LETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHE 1555

Query: 761  ---LLEILKEVENEKNDKDKKIAE----------------------LERQVKDQNKKVAN 795
               +L I  E+   K++ D+KIAE                      L+ +V+ +N+ +  
Sbjct: 1556 EAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL 1615

Query: 796  LKHKE----QVE------KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEA 845
             K  E    ++E       +++A+ L+  R  +  L D+   L D+LR ++D  E+L   
Sbjct: 1616 KKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIV 1675

Query: 846  LRESVQITAERE---MVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSL 902
             R +  + AE E     L Q E AR  AE   +ELL + E+V Q L +    L  T++ L
Sbjct: 1676 ERRANLLQAEVEELRATLEQTERARKLAE---QELLDSNERV-QLLHTQNTSLIHTKKKL 1731

Query: 903  AEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALK 962
               ET L  L++       EV +  ++A  A    K A      ++   KK Q+  A L+
Sbjct: 1732 ---ETDLMQLQS-------EVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1781

Query: 963  REKDRLVQQLK 973
            R K  L Q +K
Sbjct: 1782 RMKKNLEQTVK 1792



 Score =  134 bits (338), Expect = 4e-31
 Identities = 173/840 (20%), Positives = 367/840 (43%), Gaps = 92/840 (10%)

Query: 195  KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQA-----LQDELRIQRDLNQLFQQD 249
            K +  L K EA +  + ++   +VQE+N  +Q+ +QA     L  E R  + +   FQ +
Sbjct: 859  KTKDELAKSEAKRKELEEKLVTLVQEKND-LQLQVQAESENLLDAEERCDQLIKAKFQLE 917

Query: 250  SSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESI 309
            +  +      AE  EE    L A+  +   E   L+K ++++EL +   ++  +A +  +
Sbjct: 918  AKIKEVTER-AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 976

Query: 310  KKLLEMLQSKGLS-AKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSM--LREEMHR 366
            K L E L     + AK T E      + A  E H   L+ L  +++K NS+   + ++ +
Sbjct: 977  KNLTEELSGLDETIAKLTRE------KKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQ 1030

Query: 367  RFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQM 426
            + E+         L++ +E +      +ER  R LE ++++ +     S  + E + +Q+
Sbjct: 1031 QVED---------LESSLEQEKKLRVDLERNKRKLEGDLKLAQE----SILDLENDKQQL 1077

Query: 427  EVYRSHSKF----MKNKVE-------QLKEELSSKEAQWEELKKKAAGLQAEIGQVKQEL 475
            +       F    +++KVE       Q ++++   +A+ EEL+++    +A   + +++ 
Sbjct: 1078 DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137

Query: 476  SRKDTELLALQTKLE-----TLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE--VDALR 528
            S    EL  L  +LE     T T    + K+  E LK     ++   A LQ E  V ALR
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLK---LRRDLEEATLQHEAMVAALR 1194

Query: 529  LRLEEKETMLNKKTKQIQ----DMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQ 584
             +  +    L ++   +Q     + +EK     EI DL   ++   +    L+K    L+
Sbjct: 1195 KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLE 1254

Query: 585  EQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDR-----D 639
            +QL +   +   ++  +  L    +   T    L   L EKE  + +L   +       +
Sbjct: 1255 DQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTE 1314

Query: 640  EREKQEEIDNYKKD-----LKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDS 694
            E ++Q E +N  K+     L+  +    LL+    E++    +L+   S   S   +  +
Sbjct: 1315 ELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1374

Query: 695  RLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKA 754
            + +T  I   ++ EE  K  +Q  +  E  +EA     ++ +   LE+   R + E    
Sbjct: 1375 KYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA-----VNAKCASLEKTKQRLQGEVEDL 1429

Query: 755  QAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
              +V+R   +   ++ ++ + DK +AE + + ++   ++       +   K+S  +  E 
Sbjct: 1430 MVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAEL-------EASLKESRSLSTEL 1482

Query: 815  RRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 874
             + ++   ++  QL+   R+     + LE+ + +  +  AE    + + E +R   E + 
Sbjct: 1483 FKLKNAYEEALDQLETVKREN----KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEK 1538

Query: 875  EELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAA 934
             ++ +A+E+ +  LE  +AK+   Q  L + ++ +    AE+ + +E++    Q  +   
Sbjct: 1539 ADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETM 1598

Query: 935  ISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKS 994
             S  DA +          +++ E   LK++ +  + +++ Q  +  +  A+  +  H +S
Sbjct: 1599 QSALDAEV----------RSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLK--HLRS 1646



 Score =  130 bits (328), Expect = 5e-30
 Identities = 180/789 (22%), Positives = 349/789 (44%), Gaps = 117/789 (14%)

Query: 352  QKEKENSMLREEMHR-RFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKS 410
            + EKE + ++EE  + + E A   AK K L+        K+ ++ +   DL+ ++Q  +S
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELE-------EKLVTLVQEKNDLQLQVQA-ES 896

Query: 411  NGALSTEEREEEMKQMEVYRSHSKF-MKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIG 469
               L  EER +++ +       +KF ++ K++++ E    +E    EL  K   L+ E  
Sbjct: 897  ENLLDAEERCDQLIK-------AKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 949

Query: 470  QVKQE-------LSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQT 522
            ++K++       L++ + E  A + K++ LT + S   + I  L     A ++     Q 
Sbjct: 950  ELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAH---QQ 1006

Query: 523  EVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIEN 582
             +D L+   E+K   LNK   +++   E+  +   +   L+  L+  +RK   L+  ++ 
Sbjct: 1007 ALDDLQAE-EDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK---LEGDLKL 1062

Query: 583  LQEQLRDKEKQMSSLKERVKS-------LQADTTNTDTALTTLEEALAEKERTIERLKEQ 635
             QE + D E     L ER+K        LQ+   +  T     ++ + E +  IE L+E+
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122

Query: 636  --RDRDEREKQE-EIDNYKKDLKDLKEK------VSLLQGDLSEK-EASLLDL------- 678
               +R  R K E +  +Y ++L++L E+      V+  Q +L++K EA  L L       
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEA 1182

Query: 679  ------------KEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALE 726
                        K+HA S+A  G + D+ L+ ++  LE++K E       L  + E+  +
Sbjct: 1183 TLQHEAMVAALRKKHADSVAELGEQIDN-LQRVKQKLEKEKSEFKLEIDDLSSSMESVSK 1241

Query: 727  ARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 786
            ++A+         LE+     +D+ S+A+ + + +   L E+  +K+    +  EL RQ+
Sbjct: 1242 SKAN---------LEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL 1292

Query: 787  KDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 846
            +++   V+ L   +Q       Q  EE +R+ +  N +   L  +L+      + L E  
Sbjct: 1293 EEKESIVSQLSRSKQA----FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQY 1348

Query: 847  RESVQITAEREMVLAQEESA--------RTNAEKQVEELLMAMEKVKQELESMKAKLSST 898
             E  +  AE +  L++  S          T+A ++ EEL  A +K+ Q L+  + ++ + 
Sbjct: 1349 EEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAV 1408

Query: 899  QQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANI--ALLELSSSKKKTQE 956
                A  E     L+ E    + +V   +  +L AA+ +K  N    L E  +  +++Q 
Sbjct: 1409 NAKCASLEKTKQRLQGEVEDLMVDV--ERANSLAAALDKKQRNFDKVLAEWKTKCEESQA 1466

Query: 957  EVAALKREKDRLVQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQ---PL 1013
            E+ A  +E   L  +L +  +N  +   D  E    ++ +  Q       +QI +    +
Sbjct: 1467 ELEASLKESRSLSTELFK-LKNAYEEALDQLETVKRENKNLEQ-EIADLTEQIAENGKTI 1524

Query: 1014 LELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQ 1073
             EL+++R +++L    +                      L++ +AA E+E  K+ R QL+
Sbjct: 1525 HELEKSRKQIELEKADIQLA-------------------LEEAEAALEHEEAKILRIQLE 1565

Query: 1074 DELEKGERD 1082
                K E D
Sbjct: 1566 LTQVKSEID 1574



 Score =  129 bits (325), Expect = 1e-29
 Identities = 128/630 (20%), Positives = 290/630 (46%), Gaps = 49/630 (7%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ +  ++EE Q  K   A S  +R+E  +++         ++ +V+   E L  
Sbjct: 842  KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A+I +V +    ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 902  AEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 961

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   L   +  + K T++ + + E       ++   +D ++  
Sbjct: 962  LAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSL 1021

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
             +  + L++++E+L+  L  ++K    L+   + L+ D      ++  LE    +K++  
Sbjct: 1022 NKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLEN---DKQQLD 1078

Query: 630  ERLKEQRDRDEREKQEEIDN-------YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHA 682
            ERLK ++D +  + Q ++++       ++K +K+L+ ++  L+ ++  + A+    ++  
Sbjct: 1079 ERLK-KKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQR 1137

Query: 683  SSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEAAL------E 726
            S  A      S  L++   + + +I L +K+E E LK+   L++A   HEA +       
Sbjct: 1138 SDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKH 1197

Query: 727  ARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 786
            A +  E+ ++I +L+R   + + E S+ + E+D L   ++ V   K + +K    LE Q+
Sbjct: 1198 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQL 1257

Query: 787  KDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 846
             +   K       E++++      L E   ++  L   + +L   L +K+  + +L  + 
Sbjct: 1258 SEARGK------NEEIQRS-----LSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSK 1306

Query: 847  RESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
            +   Q T E +  L +E  A+      ++      + ++++ E  +   +  Q++L++  
Sbjct: 1307 QAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1366

Query: 907  THLTNLRA-------ERRKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSKKKTQEEV 958
            + +   R        +R + LEE  +   + L  +  + +A N     L  +K++ Q EV
Sbjct: 1367 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEV 1426

Query: 959  AALKREKDR---LVQQLKQQTQNRMKLMAD 985
              L  + +R   L   L ++ +N  K++A+
Sbjct: 1427 EDLMVDVERANSLAAALDKKQRNFDKVLAE 1456



 Score =  125 bits (315), Expect = 2e-28
 Identities = 150/717 (20%), Positives = 309/717 (43%), Gaps = 101/717 (14%)

Query: 456  ELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQ 515
            E +K+ A ++ E  + K EL++ + +   L+ KL TL  + +D +  ++   E+L   E+
Sbjct: 845  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEE 904

Query: 516  RAAIL-------QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDV 568
            R   L       + ++  +  R E++E +  + T + + + +E      +I DL+  L  
Sbjct: 905  RCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK 964

Query: 569  KERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKER- 627
             E++ +  + K++NL E+L   ++ ++ L    K+LQ      +     L++  AE+++ 
Sbjct: 965  VEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQ------EAHQQALDDLQAEEDKV 1018

Query: 628  -TIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLA 686
             ++ + K + ++   + +  ++  KK   DL+     L+GDL   + S+LDL+     L 
Sbjct: 1019 NSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD 1078

Query: 687  SSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI-- 744
                KKD     L+  +E ++   L+ + ++K             E+  RI+ LE EI  
Sbjct: 1079 ERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIK-------------ELQARIEELEEEIEA 1125

Query: 745  ---TRYKDESSKAQ--AEVDRLLEILKEV------ENEKNDK-DKKIAELERQVKDQNKK 792
               TR K E  ++    E++ L E L+E       + E N K + +  +L R +++    
Sbjct: 1126 ERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEE---- 1181

Query: 793  VANLKHKEQVE--KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESV 850
             A L+H+  V   +KK A  + E   + DNL    Q+L+    +    I++L  ++    
Sbjct: 1182 -ATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240

Query: 851  QITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLT 910
            +  A  E +    E   + A  + EE+  ++ ++  +   ++ +     + L EKE+ ++
Sbjct: 1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVS 1300

Query: 911  NLRAERRKHLEEVLEMKQE---------ALLAAISEKDANIALL------------ELSS 949
             L   ++   ++  E+K++         AL  A+     +  LL            EL  
Sbjct: 1301 QLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQR 1360

Query: 950  SKKKTQEEVAA--LKREKDRL-----VQQLKQQTQNRMKLMADNYEDDHFKSSHSNQTNH 1002
            +  K   EVA    K E D +     +++ K++   R++   +  E  + K +   +T  
Sbjct: 1361 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQ 1420

Query: 1003 KPSPDQIIQPLL-----------ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASY 1051
            +   +  ++ L+            LD+ +      +    T C +    +   L    S 
Sbjct: 1421 RLQGE--VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSL 1478

Query: 1052 NLDDDQAAWENELQKMTRG--QLQDELEKGERDNAELQEFANAILQQIADHCPDILE 1106
            +          EL K+     +  D+LE  +R+N  L++    + +QIA++   I E
Sbjct: 1479 S---------TELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHE 1526



 Score =  112 bits (281), Expect = 1e-24
 Identities = 158/736 (21%), Positives = 302/736 (41%), Gaps = 124/736 (16%)

Query: 138  TVPHSLRQAR------DNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWS 191
            T+   L +AR        ++ +L TQ   +  E   L + +E KES +S    S + F  
Sbjct: 1252 TLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQ 1311

Query: 192  PELKKERALRKDEASK-------------ITIWKEQYRVVQEENQHMQMTIQALQDELRI 238
               + +R L ++  +K               + +EQY   QE    +Q  +     E+  
Sbjct: 1312 QTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQ 1371

Query: 239  QRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQ 298
             R     ++ D+  RT E  + E  ++  QRL  + E Q + +     +LE+ + R++ +
Sbjct: 1372 WRTK---YETDAIQRTEE--LEEAKKKLAQRLQ-DSEEQVEAVNAKCASLEKTKQRLQGE 1425

Query: 299  KQTLNARDESIKKLLEMLQSKGLS---------AKATEEDHERTRRLAEAEMHVHHLESL 349
             + L    E    L   L  K  +          K  E   E    L E+      L  L
Sbjct: 1426 VEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKL 1485

Query: 350  ----------LEQKEKENSMLREEMHRRFENAPDSAKT--------------KA-LQTVI 384
                      LE  ++EN  L +E+    E   ++ KT              KA +Q  +
Sbjct: 1486 KNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545

Query: 385  EMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLK 444
            E  ++ +   E  +  ++ E+  +KS       E++EE++Q++  R++ + ++     L 
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK--RNYQRTVETMQSALD 1603

Query: 445  EELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHI- 503
             E+ S+  +   LKKK  G   ++ +++ +LS  + +       L ++  Q  D++ H+ 
Sbjct: 1604 AEVRSRN-EAIRLKKKMEG---DLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLD 1659

Query: 504  ------EVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAG 557
                  E LKE L   E+RA +LQ EV+ LR  LE+        T++ + +AE+      
Sbjct: 1660 DALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ--------TERARKLAEQ------ 1705

Query: 558  EIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTT 617
                  ++LD  ER V +L  +  +L    +  E  +  L+  V+    D  N +     
Sbjct: 1706 ------ELLDSNER-VQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAE---EK 1755

Query: 618  LEEALAEKERTIERLKEQRDRD---EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEAS 674
             ++A+ +     E LK+++D     ER K+    N ++ +KDL+ ++          EA 
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKK----NLEQTVKDLQHRLD---------EAE 1802

Query: 675  LLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPE-- 732
             L LK     +     K ++R++ LE  LE ++++  +    L+K      E     E  
Sbjct: 1803 QLALKGGKKQIQ----KLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEED 1858

Query: 733  ------MSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 786
                  + D +  L+ ++  YK ++ +A  + +  L   ++ ++E  + +++    E QV
Sbjct: 1859 RKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQV 1918

Query: 787  KDQNKKVANLKHKEQV 802
                 K  +      V
Sbjct: 1919 NKLRAKTRDFTSSRMV 1934


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  140 bits (354), Expect = 5e-33
 Identities = 210/965 (21%), Positives = 411/965 (42%), Gaps = 102/965 (10%)

Query: 163  RENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEEN 222
            +E + L+++   ++ +L      ++     EL++ER   + +  ++   ++Q R  QEE 
Sbjct: 255  KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR-EQQLRRKQEEE 313

Query: 223  QHMQMTIQALQDELRIQRD--LNQLFQQDSSSRTGEPCVAELTEENFQ---RLHAEHERQ 277
            +  Q   +  Q E R Q++    Q  +++   R  +    E  EE  +   R   E ER+
Sbjct: 314  RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373

Query: 278  AKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLA 337
             ++L   ++   E +LR E Q +    R++ +++  ++ + + L  +      ++ RR  
Sbjct: 374  EQQLRREQQLRREQQLRREQQLR----REQQLRREQQLRREQQLRREQQLRREQQLRREQ 429

Query: 338  EAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERG 397
            E E H    E   EQ+ +E  + RE+  RR     D  K +      E +  K    ++ 
Sbjct: 430  EEERH----EQKHEQERREQRLKREQEERR-----DWLKREEETERHEQERRK----QQL 476

Query: 398  LRDLEEEIQ--MLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWE 455
             RD EEE +   LK    L  EER E+ ++ E      + ++ + E+ +E+   ++ + E
Sbjct: 477  KRDQEEERRERWLK----LEEEERREQQERRE------QQLRREQEERREQRLKRQEEEE 526

Query: 456  ELKKKAAG---LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTA 512
             L+++      L+ E  + +++L +++ E    Q + E    +  + ++  ++LK     
Sbjct: 527  RLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD-QLLKREEER 585

Query: 513  KEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERK 572
            ++QR    Q E    RL+ EE E +  ++ ++ +   EE   +  +   L    + +ER+
Sbjct: 586  RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ--QLLKSEEQEERR 643

Query: 573  VNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERL 632
               L+++ +  +EQ   +E++   L++R+K    +           E A  E+E+  ER+
Sbjct: 644  QQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ------ELAEEEQEQARERI 697

Query: 633  KEQRDRDEREKQEEIDN-----YKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLAS 687
            K +  + + + + E D      Y +  K   ++    Q +   +  S L  +E   +   
Sbjct: 698  KSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ 757

Query: 688  SGLKKDSRLKTLEIALEQKKE---ECLKMESQLKKAHEAALEARASPEMSDRIQHLEREI 744
               ++  R  T +   E+K E   + L     L++  E  L A    +   R    E E 
Sbjct: 758  QQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE- 816

Query: 745  TRYKDESSKAQAEVDRLLEILKEVEN-EKNDKDKKIAELERQVKDQNKKVANLKHKEQVE 803
               K++  + + E ++ L+ L+E E  ++ ++ +++ E E  +++  ++    + +EQ  
Sbjct: 817  ---KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER---RRSQEQRR 870

Query: 804  KKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQE 863
             +K    LEE R+R  +   +   LQ+ LRK+   ++E EE L+       ERE    QE
Sbjct: 871  DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE-----EREKRRRQE 925

Query: 864  ESARTNAEKQV---EELLMAMEKVK---QELESMKAKLSSTQQS----LAEKETHLTNLR 913
            +  +   E+Q+   EE L+  E+ K   QE E    K    QQ     L E+        
Sbjct: 926  QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985

Query: 914  AERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKRE--KDRLVQQ 971
             E++   EE L+ ++E LL    EK            K + Q+E   L RE  + R +Q+
Sbjct: 986  REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045

Query: 972  LKQQTQNRMKLMADNYEDDHFKSSHSNQTNHKPSPDQIIQPLLELDQNRSKLKLYIGHLT 1031
             ++Q +   +L     +++        +T  +   ++  +   EL Q   +L        
Sbjct: 1046 RERQYREEEELQ----QEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL-------- 1093

Query: 1032 TLCHDRDPLILRGLTPPASYNLDDDQAAWENELQKMTRGQLQDELEKGERDNAELQEFAN 1091
                      LR           + Q   E ELQ+     L++E EK  R   E Q    
Sbjct: 1094 ----------LREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143

Query: 1092 AILQQ 1096
              +QQ
Sbjct: 1144 EEVQQ 1148



 Score =  129 bits (323), Expect = 2e-29
 Identities = 185/902 (20%), Positives = 372/902 (41%), Gaps = 106/902 (11%)

Query: 154  LQTQLKEVLRENDLLRKDVEVKESKLSSSM-------------NSIKTFWSPELKKERAL 200
            L+ + +E  RE +L  ++ E    ++ S +                K +  P  ++ +  
Sbjct: 672  LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731

Query: 201  RKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
            R+++  K    + + +  +EE  H Q      Q E   +RD    +Q +  S  G   ++
Sbjct: 732  RQEQEEKRRRRESELQWQEEERAHRQ------QQEEEQRRDFTWQWQAEEKSERGRQRLS 785

Query: 261  E---LTEENFQRLHAEHERQAKELFLLRKTLEEMELRI--ETQKQTLNARDESIKKLLEM 315
                L E+  ++L AE  +Q ++ FL  +  +E   R   E +K+     +E   +  E 
Sbjct: 786  ARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER 845

Query: 316  LQSKGLSAKATEEDHERTR------------RLAEAEMHVHHL----ESLLEQKEKENSM 359
             Q         +ED ER R            +L E      H      +L EQ  KE  +
Sbjct: 846  AQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL 905

Query: 360  LREEMH------RRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGA 413
            L+EE        R      +  +    +  ++ ++ ++   ER  R  +E  +  + +  
Sbjct: 906  LQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965

Query: 414  LSTEERE------EEMKQME---VYRSHSKFMKNKVEQLKEELSSKEAQ-WEELKKKAAG 463
            L  +E +      E+ ++ E    YR   +  + + + L+EE   +  Q WE   +K   
Sbjct: 966  LQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDE 1025

Query: 464  LQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTE 523
            LQ E    +++L R++ E   LQ +      +    ++  ++L E    + ++    Q  
Sbjct: 1026 LQQE----EEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081

Query: 524  VDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENL 583
             +   L+ EE++ +  +  K+ +   E +  +  E+   ++ L  +ER+    +++ + L
Sbjct: 1082 KEE-ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE----KRRRQEL 1136

Query: 584  QEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEA-LAEKERTIERLKEQRDRDERE 642
            + Q R++E+     ++ ++         +      EE  L ++E  + R ++++ R ERE
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196

Query: 643  KQ----EEIDNYKKD--LKDLKEKVSLLQGDLSEKEASLLDLK--------EHASSLASS 688
            +Q    EE+   K+    +D  ++  L      EKE ++ D K        E    L  S
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256

Query: 689  GLKKDSRLKTLEIALEQKKEECLKMES---QLKKAH---EAALEARASPEMS--DRIQHL 740
             L+     + L+  L +++E   + E    Q +  H   E  LE     E    DR    
Sbjct: 1257 QLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQE 1316

Query: 741  EREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKE 800
            E+++ R + E  + + E DR     K  E E+  ++++   L RQ +D+  +   L+H+E
Sbjct: 1317 EKQLLREEREEKRRRQETDR-----KFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371

Query: 801  QVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVL 860
            Q  K    +     + RE       QQL+   R++  R +   +   E  Q++ +     
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431

Query: 861  AQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHL 920
             +EE  +   +++  + L   ++++QE      K    +Q L E+E    + +   RK L
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQQLRQE---RHRKFREEEQLLQEREEQQLHRQERDRKFL 1488

Query: 921  EEVLEMKQEALLAAISEKDANIALLELSS---SKKKTQEEVAALKREKDRLVQQLKQQTQ 977
            EE  +++++       E+D      EL S    +K  +EE    ++++ R   Q +QQ +
Sbjct: 1489 EEEQQLRRQ-------ERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 978  NR 979
             +
Sbjct: 1542 RQ 1543



 Score =  120 bits (300), Expect = 9e-27
 Identities = 187/881 (21%), Positives = 376/881 (42%), Gaps = 122/881 (13%)

Query: 153  DLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWK 212
            +LQ + +++LRE    R+  E                W  + +K+  L+++E   +   +
Sbjct: 995  ELQQEEEQLLREEREKRRRQE----------------WERQYRKKDELQQEEEQLLREER 1038

Query: 213  EQYRVVQEENQH-----MQMTIQAL---QDELRIQRDLNQLFQQDSSSRTGEPCVAELTE 264
            E+ R+ + E Q+     +Q   + L   + E R +++L + ++++   +  E  +  L E
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQL--LRE 1096

Query: 265  ENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAK 324
            E  +R   E ERQ +E   L++  EE  LR E +K+     +   ++  E+ Q +    +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQE-EEQLLREEREKRRRQELERQYREEEEVQQEE---EQ 1152

Query: 325  ATEEDHERTRRLAEAEMHVHHLESLLEQKEK----ENSMLREEMHRRFENAPDSAKTKAL 380
               E+ E+ RR  E E      E L +++E+    E    R+E  R++    +  + K  
Sbjct: 1153 LLREEPEKRRR-QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211

Query: 381  QTVIE------------------MKDSKISSMERG-----------LRDLEEEIQMLKSN 411
            Q   +                  ++D+K+    R            LRD + +  +    
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271

Query: 412  GALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELK----KKAAGLQAE 467
            G     +RE+E ++ +    H      + EQL+ E   KEA+  + K    K+    + E
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFP----EEEQLERE-EQKEAKRRDRKSQEEKQLLREERE 1326

Query: 468  IGQVKQELSRK--DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVD 525
              + +QE  RK  + E L  + + + L  Q  D K      +E L  +EQ    L+ E  
Sbjct: 1327 EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR----EEELRHQEQGRKFLEEEQ- 1381

Query: 526  ALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQE 585
              RLR +E+E    K+ +Q++   +E+  Q  +  D K   + ++       +K    ++
Sbjct: 1382 --RLRRQERERKFLKEEQQLR--CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437

Query: 586  QLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE 645
            Q+R +E++   L+E  +  Q             EE L ++    +  +++RDR   E+++
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFRE-----EEQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 646  EIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE--HASSLASSGLKKDSRLKTLEIAL 703
            ++   ++D K  ++++        E E   L+ ++  H        L+++ +L+  E   
Sbjct: 1493 QLRRQERDRKFREQELRS-----QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQ 1547

Query: 704  EQKKEECLKM--ESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRL 761
            +++++   K   E QL++  E   E + S +  DR   LE +  R +++  K   +  +L
Sbjct: 1548 QRRQDRDRKFREEEQLRQERE---EQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQL 1604

Query: 762  L--EILKEVENEKNDKDKKIAEL-----ERQVKDQNKKVANLKHKEQVEKKKSAQMLEEA 814
               E  +++  E++ K ++  +L     E+Q+  Q +    L+ + Q+ +++  Q L   
Sbjct: 1605 RRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD 1664

Query: 815  R----RREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870
            R    R E+ L    ++ Q   +++D +  E E+ LR       ERE    QEE      
Sbjct: 1665 RDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-----ERERKFLQEEQQLRRQ 1719

Query: 871  EKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEA 930
            E  +E      E+++QE E  + +     + + E+E        ++ +  E   + ++E 
Sbjct: 1720 E--LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE 1777

Query: 931  LLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQ 971
             L    E+     L    S +K  +EE    +RE+ +L  Q
Sbjct: 1778 QLRQEREEQ---QLRSQESDRKFREEEQLRQEREEQQLRPQ 1815



 Score =  117 bits (293), Expect = 6e-26
 Identities = 185/874 (21%), Positives = 385/874 (44%), Gaps = 89/874 (10%)

Query: 144  RQARDNTIMDLQTQLKEVLR--ENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALR 201
            R+ R    ++ Q + +E L+  E  LLR++ E +  +        +     + ++E+ LR
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQ--ERERQCREEEELQQEEEQLLR 1125

Query: 202  KD-EASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVA 260
            ++ E  +    + QYR  +E  Q  +  ++  + E R +++L + ++++   +  E    
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQEEEQLLRE-EPEKRRRQELERQYREEEELQQEEE--- 1181

Query: 261  ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLL---EMLQ 317
            +L  E  ++   E ERQ +E   L++   +   R E Q+  L  + E  K+       + 
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241

Query: 318  SKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKT 377
             KG   +   +  +   R  +++  + HL  L EQ+E++    R    +R  + P+  + 
Sbjct: 1242 CKGRENEQFRQLEDSQLRDRQSQQDLQHL--LGEQQERDREQERRRWQQRDRHFPEEEQL 1299

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV---YRSHSK 434
            +      E K++K     R  R  +EE Q+L+       EEREE+ ++ E    +R   +
Sbjct: 1300 ERE----EQKEAK-----RRDRKSQEEKQLLR-------EEREEKRRRQETDRKFREEEQ 1343

Query: 435  FMKNKVEQ-LKEELSSKEAQWEELKKKAAG---LQAEIGQVKQELSRK---DTELLALQT 487
             ++ + EQ L+ +   ++ + EEL+ +  G   L+ E    +QE  RK   + + L  Q 
Sbjct: 1344 LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQE 1403

Query: 488  KLETLTN----QFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 543
            + + L      +F + +Q +   +     +E+   + + E +  R  LEE++ +  ++ +
Sbjct: 1404 REQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERE--RKFLEEEQQLRQERHR 1461

Query: 544  QIQDMAEEKGTQAGEIHDL----KDMLDVKERKVNVLQKKIENLQEQ-LRDKEKQMSSLK 598
            + ++  EE+  Q  E   L    +D   ++E +    Q++    +EQ LR +E +   L+
Sbjct: 1462 KFRE--EEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE---EIDNYKKDLK 655
            E     Q             E+ L  +ER  +R ++ RDR  RE+++   E +  +   +
Sbjct: 1520 EEQ---QLHRQQRQRKFLQEEQQLRRQERGQQR-RQDRDRKFREEEQLRQEREEQQLSRQ 1575

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLK-----KDSRLKTLEIALEQKKEEC 710
            +   K  L +  +  +E     +++        G +     +D + +  E  L++++E+ 
Sbjct: 1576 ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635

Query: 711  LKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVEN 770
            L  + + +K  E        P++  R Q  E+++   +D   +   E ++LL+  +E + 
Sbjct: 1636 LHRQERDRKFLEE------EPQL--RRQEREQQLRHDRDRKFR---EEEQLLQEGEEQQL 1684

Query: 771  EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
             + ++D+K  E E+Q++ Q ++   L+ ++Q+ +    Q LE   R E+ L   ++Q Q 
Sbjct: 1685 RRQERDRKFREEEQQLRRQERERKFLQEEQQLRR----QELERKFREEEQLRQETEQEQL 1740

Query: 831  SLRKKDDRIEELEEAL--RESVQITA-EREMVLAQEESARTNAEKQV------EELLMAM 881
              +++  +I E E+    RE  Q+   ER+    +EE  R   E+Q       +      
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800

Query: 882  EKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDAN 941
            E+++QE E  + +          +E  L     E+R   E   + + E   A   +    
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860

Query: 942  IALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
               L     +K+ QE    L+ E  R  Q+ +Q+
Sbjct: 1861 EQELWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894



 Score =  113 bits (283), Expect = 9e-25
 Identities = 165/824 (20%), Positives = 349/824 (42%), Gaps = 94/824 (11%)

Query: 212 KEQYRVVQEENQHMQ--MTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQR 269
           +E+ R  +E+ Q  +   T +   +E   +R+L +L       R G     +   E   R
Sbjct: 183 REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLEL------RRKGREEKQQQRRERQDR 236

Query: 270 LHAEHERQA--KELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATE 327
           +  E E +   K   +LRK  E+++     +++ L   +E ++K    L+ + L  +  E
Sbjct: 237 VFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK----LERQELRRERQE 292

Query: 328 EDHERTRRLAEAEMHVHHLESLLEQKE--KENSMLREEMHRRFEN--APDSAKTKALQTV 383
           E+ ++ R   E ++     E   EQ+E  +E    RE+   R E     +  + +  Q  
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352

Query: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEE---REEEMKQMEVYRSHSKFMKNKV 440
            E ++ +     R  ++ E   Q L+    L  E+   RE+++++ +  R   +  +   
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE-- 410

Query: 441 EQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSK 500
           +QL+ E   +  Q  +L+++    + E  + K E  R++  L   Q +      +  +++
Sbjct: 411 QQLRREQQLRREQ--QLRREQ---EEERHEQKHEQERREQRLKREQEERRDWLKREEETE 465

Query: 501 QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIH 560
           +H +  ++    ++Q     +     L+L  EE+     ++ +Q++   EE+  Q  +  
Sbjct: 466 RHEQERRKQQLKRDQEE---ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQ 522

Query: 561 DLKDMLDVKERKVNVLQKKIENLQEQL--RDKEKQMSSLKERVKSLQADTTNTDTALTTL 618
           + ++ L  + R    L+++ E  +EQL  R++EK++   +   +  +      D  L   
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582

Query: 619 EEALAE--KERTIERLKEQRDRDEREKQEEIDNYKKDLK----DLKEKVSLLQGDLSEKE 672
           EE   +  K    ERL+++  R+E E+ E+ +  ++ LK    + + +  LL+ +  ++E
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE-EQEE 641

Query: 673 ASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAA-------- 724
                L+          LK++   + LE  L+++ EE  + +   ++  E A        
Sbjct: 642 RRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI 701

Query: 725 ------LEARASPEMS----------DRIQHLEREITRYKDESSKAQAEVDRLLEILKEV 768
                 LE+ A    S           + +  E+E  R + ES     E +R     +E 
Sbjct: 702 PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761

Query: 769 E-----------NEKNDKDKKIAELERQVKDQNKKVANLKHKEQ------VEKKKSAQML 811
           E            EK+++ ++       +++Q ++    + ++Q       E+++  Q  
Sbjct: 762 EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 812 EEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAE 871
            + R RE  L    ++ Q   R++  +++E E+ L+E      ++E   +QE+       
Sbjct: 822 RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE------DQERRRSQEQRRDQKWR 875

Query: 872 KQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEAL 931
            Q+EE             +++ +L   QQ L E+E  L     E+R+  E+  + ++E  
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQ 935

Query: 932 LAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQ 975
           L    E+     LL     K++ QE     +  KD+ +QQ ++Q
Sbjct: 936 LQQEEEQ-----LLREEREKRRRQERERQYR--KDKKLQQKEEQ 972



 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 133/687 (19%), Positives = 292/687 (42%), Gaps = 90/687 (13%)

Query: 455  EELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKE 514
            EE + +  G ++ +   +QE  ++  E    Q + E    +    ++    L E     E
Sbjct: 97   EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156

Query: 515  QRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM-AEEKGTQAGEIHDLKDMLD---VKE 570
            ++  + Q +    R R +E+     ++ ++ ++  AEE+  Q+ + H+ ++  D   ++ 
Sbjct: 157  KQERLEQRD----RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212

Query: 571  RKVNVLQKK-IENLQEQLRDK------EKQMSSLKERVKSLQADTTNTDTALTTLEEALA 623
            R++  L++K  E  Q+Q R++      E++    ++R   L+ +           +  L 
Sbjct: 213  RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 624  EKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHAS 683
            E+E  + +L+ Q  R ER+++E+     +  + L+ K    + +  E+     + +E   
Sbjct: 273  EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 684  SLASSGLKKDS-----------------------------RLKTLEIALEQKKEECLKME 714
                  L+++                              R + L    + ++E+ L+ E
Sbjct: 333  ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392

Query: 715  SQLKKAHEAALEARASPEMS-DRIQHLERE--ITRYKDESSKAQA-EVDRLLEILKEVEN 770
             QL++  +   E +   E    R Q L RE  + R ++E    Q  E +R  + LK  + 
Sbjct: 393  QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452

Query: 771  EKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQD 830
            E+ D  K+  E ER   +Q ++   LK  ++ E+++    LEE  RRE       Q  ++
Sbjct: 453  ERRDWLKREEETERH--EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510

Query: 831  SLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELES 890
               +++ R++  EE  R   ++ +E+++   QEE  R    K+ EE  +  E+ +Q L+ 
Sbjct: 511  QEERREQRLKRQEEEERLQQRLRSEQQLRREQEE-RREQLLKREEEKRLEQERREQRLKR 569

Query: 891  MKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSS 950
             + +    Q    E+E     L+ E+ + LE+ L+ ++   +  + +++     L+    
Sbjct: 570  EQEE-RRDQLLKREEERRQQRLKREQEERLEQRLKREE---VERLEQEERREQRLKREEP 625

Query: 951  KKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYEDD-----HFKSSHSNQTNHKPS 1005
            +++ ++++   + +++R  QQL+++ Q R +      E++       K  H  +   +  
Sbjct: 626  EEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQEL 685

Query: 1006 PDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQAAWENELQ 1065
             ++      E +Q R ++K  I                   P   + L+ +  A ++++ 
Sbjct: 686  AEE------EQEQARERIKSRI-------------------PKWQWQLESEADARQSKVY 720

Query: 1066 KMTRGQ-----LQDELEKGERDNAELQ 1087
               R Q      Q++ EK  R  +ELQ
Sbjct: 721  SRPRKQEGQRRRQEQEEKRRRRESELQ 747



 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 90/401 (22%), Positives = 172/401 (42%), Gaps = 50/401 (12%)

Query: 143  LRQARDNTIMDLQTQLKEVLRENDLLRKDVEVKESKLSSSMNSIKTFWSPELKKERALRK 202
            LRQ R+   +  Q + ++   E   +R+  E +   +       +     +L++ER  + 
Sbjct: 1563 LRQEREEQQLSRQERDRKFRLEEQKVRRQ-EQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621

Query: 203  DEASKITIWKEQYRVVQEEN------QHMQMTIQALQDELRIQRDLN------------- 243
             E  ++   +E+ ++ ++E       +  Q+  Q  + +LR  RD               
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681

Query: 244  -QLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTL 302
             QL +Q+   +  E    +L  +  +R   + E+Q +   L RK  EE +LR ET+++ L
Sbjct: 1682 QQLRRQERDRKFREE-EQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740

Query: 303  NARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLRE 362
              R E  +K+LE  Q +    +      ER R+  E E         L Q+ +E  +  +
Sbjct: 1741 R-RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ--------LRQEREEQQLRSQ 1791

Query: 363  EMHRRFENAPDSAKTKALQTV-IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE 421
            E  R+F       + +  Q +  + +D K    E  L+ LEE+ Q L+       +ER+ 
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ-LEEQEQRLR-------QERDR 1843

Query: 422  EMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTE 481
            + +  E + +  K  + + E  +EE   K  Q  E K +   ++ +  Q +++  R+  E
Sbjct: 1844 QYRAEEQFATQEKSRREEQELWQEE-EQKRRQERERKLREEHIRRQ--QKEEQRHRQVGE 1900

Query: 482  LLALQTK-----LETLTNQFSDSKQHIEVLKESLTAKEQRA 517
            + + + K     LE  T+QF+        L E +  +EQR+
Sbjct: 1901 IKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYI--QEQRS 1939



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 61/291 (20%), Positives = 123/291 (42%), Gaps = 62/291 (21%)

Query: 749 DESSKAQAE-VDRLLEILKEVEN----------------------------------EKN 773
           DE  +A+ +  + LL+  ++ E+                                  E++
Sbjct: 96  DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155

Query: 774 DKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQML--------------EEARRRE- 818
           +K +++ + +RQ +D+       + +E+ E++   + L              E+ RRRE 
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 819 -DNLNDSSQQLQDSLRKKDDRI--EELEEALRESVQITAEREMVLAQEESARTNAEKQVE 875
            +      ++ Q   R++ DR+  EE E+  R+   +  + E  L +EE  R    ++ E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275

Query: 876 ELLMAME-----KVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE--EVLEMKQ 928
           E L  +E     + +QE E  + +L   QQ   ++E      + ERR+  E  E  E ++
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335

Query: 929 EALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNR 979
           E  L    E+     L      +++ +E+    ++E++R  QQL+++ Q R
Sbjct: 336 EQQLRREQEERREQQLRR--EQEEERREQQLRREQEEERREQQLRREQQLR 384


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score =  140 bits (354), Expect = 5e-33
 Identities = 184/917 (20%), Positives = 390/917 (42%), Gaps = 139/917 (15%)

Query: 195  KKERALRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELR-IQRDLNQLFQQDSSSR 253
            K +  L K EA +  + ++   ++QE+N  +Q+ +QA  D L   +   +QL +      
Sbjct: 862  KTKEELAKTEAKRKELEEKMVTLMQEKND-LQLQVQAEADSLADAEERCDQLIKTKIQLE 920

Query: 254  TGEPCVAELTEENFQ---RLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIK 310
                 V E  E+  +    L A+  +   E   L+K ++++EL +   ++  +A +  +K
Sbjct: 921  AKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 980

Query: 311  KLLEMLQSKGLSA---------KATEEDHERT---------------RRLAEAEMHVHHL 346
             L E  +  GL           KA +E H++T               +   + E  V  L
Sbjct: 981  NLTE--EMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDL 1038

Query: 347  ESLLEQKEK----------------------------ENSMLREEMHRR-FENAPDSAKT 377
            E  LEQ++K                            +   L E++ ++ FE +   +K 
Sbjct: 1039 EGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098

Query: 378  KALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVY-------- 429
            +  Q +      KI  ++  + +LEEEI+  +++ A + ++R +  +++E          
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1158

Query: 430  -----------RSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRK 478
                       +  ++F K +   L+E     EA    L+KK A   AE+G+    L R 
Sbjct: 1159 GATSAQIEMNKKREAEFQKMR-RDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217

Query: 479  DTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETML 538
              +L   +++++    +  D   ++E + ++    E+    L+ ++  ++ + EE++ ++
Sbjct: 1218 KQKLEKEKSEMKM---EIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274

Query: 539  NKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLK 598
            N  T Q   +  E G  + ++ +   ++    R      ++IE L+ QL ++ K  S+L 
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLK 658
              ++S + D           +EA AE +R + +   +  +   + + +     ++L++ K
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394

Query: 659  EKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLK 718
            +K   L   L + E  +  +    +SL  +  +  + ++ L I +E+    C  ++ + +
Sbjct: 1395 KK---LAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451

Query: 719  KAHEAALEARASPEMSD-RIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDK 777
               +   E +   E +   ++  ++E      E  K +   +  L+ L+ ++ E  +  +
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQ 1511

Query: 778  KIAELERQVKDQNKKVANL-KHKEQVEKKKSAQM--LEEAR-----------RREDNLND 823
            +I++L  Q+ +  K++  L K K+QVE++KS     LEEA            R +  LN 
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571

Query: 824  SSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA---EKQVEELLMA 880
               ++   + +KD+ I++++   R  ++I    +  L  E  +R +A   +K++E  L  
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMK---RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNE 1628

Query: 881  MEKVKQELESMKAKL----SSTQQSLAEKETHLTN-LRA-----------ERRKHL--EE 922
            ME        M A+      +TQ  L + + HL + LR+           ERR +L   E
Sbjct: 1629 MEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE 1688

Query: 923  VLEMKQEALLAAISEKDANIALLELS--------------SSKKKTQEEVAALKREKDRL 968
            + E++        S K A   LL+ S              ++KKK + +++ ++ E + +
Sbjct: 1689 IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDI 1748

Query: 969  VQQLKQQTQNRMKLMAD 985
            +Q+ +   +   K + D
Sbjct: 1749 IQEARNAEEKAKKAITD 1765



 Score =  121 bits (303), Expect = 4e-27
 Identities = 160/751 (21%), Positives = 323/751 (43%), Gaps = 76/751 (10%)

Query: 390  KISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSS 449
            K +  E+ + +++EE +  K   A +  +R+E  ++M         ++ +V+   + L+ 
Sbjct: 845  KSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLAD 904

Query: 450  KEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKES 509
             E + ++L K    L+A+I +V +    ++     L  K   L ++ S+ K+ I+ L+ +
Sbjct: 905  AEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELT 964

Query: 510  LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVK 569
            L   E+     + +V  L   +   +  + K TK      E+K  Q      L D L  +
Sbjct: 965  LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTK------EKKALQEAHQQTLDD-LQAE 1017

Query: 570  ERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTI 629
            E KVN L K    L++Q+ D E  +   K+    L+      +  L   +E+  + E   
Sbjct: 1018 EDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDK 1077

Query: 630  ERLKEQRDRDEREK---QEEIDN-------YKKDLKDLKEKVSLLQGDLSEKEASLLDLK 679
            ++L E+  + E E    Q +I++        +K +K+L+ ++  L+ ++  + AS    +
Sbjct: 1078 QQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137

Query: 680  EHASSLA------SSGLKKDSRLKTLEIALEQKKE-ECLKMESQLKKA---HEAAL---- 725
            +  S L+      S  L++     + +I + +K+E E  KM   L++A   HEA      
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197

Query: 726  --EARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELE 783
               A +  E+ ++I +L+R   + + E S+ + E+D L   ++ V   K + +K    LE
Sbjct: 1198 KKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALE 1257

Query: 784  RQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELE 843
             Q+ +       +K KE+ +++    +  +  R +    + S+QL +    KD  + +L 
Sbjct: 1258 DQLSE-------IKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDE----KDTLVSQLS 1306

Query: 844  EALRESVQITAEREMVLAQEESARTNAEKQVE------ELLMAMEKVKQELES-MKAKLS 896
               +   Q   E +  L +E  A++     ++      +LL    + +QE ++ ++  +S
Sbjct: 1307 RGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMS 1366

Query: 897  STQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA-NIALLELSSSKKKTQ 955
                 +A+  T       +R + LEE  +   + L  A    +A N     L  +K++ Q
Sbjct: 1367 KANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQ 1426

Query: 956  EEVAALKREKDR---LVQQLKQQTQNRMKLMAD---NYEDDHFKSSHSNQTNH------- 1002
             EV  L  + +R       L ++ +N  K++A+     E+ H +   S + +        
Sbjct: 1427 NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELF 1486

Query: 1003 --KPSPDQIIQPLLELDQNRSKLKLYIGHLTTLCHDRDPLI--LRGLTPPASYN------ 1052
              K + ++ +  L  L +    L+  I  LT    +    I  L  +             
Sbjct: 1487 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQA 1546

Query: 1053 -LDDDQAAWENELQKMTRGQLQDELEKGERD 1082
             L++ +A+ E+E  K+ R QL+    K E D
Sbjct: 1547 ALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577



 Score =  115 bits (288), Expect = 2e-25
 Identities = 151/775 (19%), Positives = 321/775 (41%), Gaps = 81/775 (10%)

Query: 200  LRKDEASKITIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCV 259
            LRK  A  +    EQ   +Q   Q ++     ++ E+    DL    +  S ++     +
Sbjct: 1196 LRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID---DLASNMETVSKAKGNLEKM 1252

Query: 260  AELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSK 319
                E+    +  + E Q +    L   L     R++T+    + + +    L+  L S+
Sbjct: 1253 CRALEDQLSEIKTKEEEQQR----LINDLTAQRARLQTESGEYSRQLDEKDTLVSQL-SR 1307

Query: 320  GLSA---------KATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFEN 370
            G  A         +  EE+ +    LA A     H   LL ++ +E    + E+ R    
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSK 1367

Query: 371  APDSA-------KTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEM 423
            A           +T A+Q   E++++K    +R L+D EE ++ + +  A S E+ ++ +
Sbjct: 1368 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR-LQDAEEHVEAVNAKCA-SLEKTKQRL 1425

Query: 424  KQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELL 483
            +             N+VE L  ++    A    L KK       + + KQ+      EL 
Sbjct: 1426 Q-------------NEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1472

Query: 484  ALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTK 543
            A Q +  +L+ +    K   E   + L   ++    LQ E+  L  ++ E    +++  K
Sbjct: 1473 ASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1532

Query: 544  QIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQ----LRDKEKQMSSLK- 598
              + + +EK      + + +  L+ +E K+  +Q ++  ++ +    + +K++++  +K 
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592

Query: 599  ERVKSLQADTTNTDTALTTLEEALAEK---ERTIERLKEQRDRDEREKQEEIDNYKKDLK 655
              ++ +++  +  D  + +  +A+  K   E  +  ++ Q +   R   E + NY+    
Sbjct: 1593 NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQA 1652

Query: 656  DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715
             LK+    L   L  +E    DLKE  + +       + R   L+  +E+ +    + E 
Sbjct: 1653 ILKDTQLHLDDALRSQE----DLKEQLAMV-------ERRANLLQAEIEELRATLEQTER 1701

Query: 716  QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLL----EILKEVENE 771
              K A +  L+A      S+R+Q L  + T   +   K + ++ ++     +I++E  N 
Sbjct: 1702 SRKIAEQELLDA------SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNA 1755

Query: 772  KNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQL--- 828
            +    K I +     ++  K+     H E+++K      LE+  +   +  D ++QL   
Sbjct: 1756 EEKAKKAITDAAMMAEELKKEQDTSAHLERMKKN-----LEQTVKDLQHRLDEAEQLALK 1810

Query: 829  --QDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQ 886
              +  ++K + R+ ELE  +    +   E    L + E        Q EE    + +++ 
Sbjct: 1811 GGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQD 1870

Query: 887  ELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDAN 941
             ++ ++AK+ S ++  AE+    +N+   + + ++  LE  +E   A I+E   N
Sbjct: 1871 LVDKLQAKVKSYKRQ-AEEAEEQSNVNLSKFRRIQHELEEAEER--ADIAESQVN 1922



 Score =  114 bits (286), Expect = 4e-25
 Identities = 159/792 (20%), Positives = 334/792 (42%), Gaps = 92/792 (11%)

Query: 142  SLRQARDNTIMDLQTQLKEVLRENDLLRKD---VEVKESKLSSSMNSIKTFWSPELKKER 198
            +LR+   +++ +L  Q+  + R    L K+   ++++   L+S+M ++        K  R
Sbjct: 1195 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254

Query: 199  ALRKDEASKI-TIWKEQYRVVQEENQHMQMTIQALQDELRIQRDLNQLFQQD---SSSRT 254
            AL +D+ S+I T  +EQ R++ +      +T Q  + +        QL ++D   S    
Sbjct: 1255 AL-EDQLSEIKTKEEEQQRLIND------LTAQRARLQTESGEYSRQLDEKDTLVSQLSR 1307

Query: 255  GEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 314
            G+    +  EE  ++L  E + ++     L+ +  + +L  E  ++   A+ E     L+
Sbjct: 1308 GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE-----LQ 1362

Query: 315  MLQSKGLSAKA-------------TEEDHERTRRLAE----AEMHVHHLESLLEQKEKEN 357
               SK  S  A             TEE  E  ++LA+    AE HV  + +     EK  
Sbjct: 1363 RAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTK 1422

Query: 358  SMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTE 417
              L+ E+             + L   +E  ++  +++++  R+ ++ +   K       +
Sbjct: 1423 QRLQNEV-------------EDLMIDVERTNAACAALDKKQRNFDKILAEWK-------Q 1462

Query: 418  EREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSR 477
            + EE   ++E  +  S+ +  ++ ++K        Q E LK++   LQ EI  + ++++ 
Sbjct: 1463 KCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAE 1522

Query: 478  KDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETM 537
                +  L+   + +  + S+ +  +E  + SL  +E +   +Q E++ ++  ++ K   
Sbjct: 1523 GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRK--- 1579

Query: 538  LNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSL 597
            + +K ++I  M   K      +  ++  LD + R  N   +  + ++  L + E Q++  
Sbjct: 1580 IAEKDEEIDQM---KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHA 1636

Query: 598  KERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREK---QEEIDNYKKDL 654
                     +  NT   L   +  L +  R+ E LKEQ    ER     Q EI+  +  L
Sbjct: 1637 NRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1696

Query: 655  KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKME 714
            +  +    + + +L +    +  L    +SL ++  K ++ +  ++  +E   +E    E
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAE 1756

Query: 715  SQLKKA-HEAALEARASPEMSDRIQHLER----------EITRYKDESSK-----AQAEV 758
             + KKA  +AA+ A    +  D   HLER          ++    DE+ +      + ++
Sbjct: 1757 EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816

Query: 759  DRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRE 818
             +L   ++E+E E   + K+  E  + ++   +KV  L ++            EE R+  
Sbjct: 1817 QKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQ-----------TEEDRKNI 1865

Query: 819  DNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELL 878
              L D   +LQ  ++    + EE EE    ++      +  L + E     AE QV +L 
Sbjct: 1866 LRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLR 1925

Query: 879  MAMEKVKQELES 890
            +   +V  ++ S
Sbjct: 1926 VKSREVHTKIIS 1937


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.123    0.315 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,104,439
Number of Sequences: 37866
Number of extensions: 1741083
Number of successful extensions: 45002
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 880
Number of HSP's successfully gapped in prelim test: 1604
Number of HSP's that attempted gapping in prelim test: 11354
Number of HSP's gapped (non-prelim): 12395
length of query: 1116
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1003
effective length of database: 13,968,660
effective search space: 14010565980
effective search space used: 14010565980
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.