Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 38044112
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38044112 restin isoform b [Homo sapiens]
(1392 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38044112 restin isoform b [Homo sapiens] 2666 0.0
gi|4506751 restin isoform a [Homo sapiens] 2648 0.0
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 786 0.0
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 768 0.0
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 193 1e-48
gi|71061468 centromere protein E [Homo sapiens] 182 1e-45
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 175 2e-43
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 174 4e-43
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 174 7e-43
gi|18496983 CAP-GLY domain containing linker protein 3 [Homo sap... 173 9e-43
gi|31982881 CAP-GLY domain containing linker protein family, mem... 173 1e-42
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 173 1e-42
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 172 2e-42
gi|58530840 desmoplakin isoform I [Homo sapiens] 171 4e-42
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 171 4e-42
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 170 1e-41
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 170 1e-41
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 170 1e-41
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 170 1e-41
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 170 1e-41
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 170 1e-41
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 170 1e-41
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 170 1e-41
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 170 1e-41
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 169 1e-41
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 169 1e-41
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 169 1e-41
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 169 1e-41
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 169 1e-41
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 169 2e-41
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 2666 bits (6910), Expect = 0.0
Identities = 1392/1392 (100%), Positives = 1392/1392 (100%)
Query: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
Sbjct: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
Query: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
Sbjct: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
Query: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
Sbjct: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
Query: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
Sbjct: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
Query: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV 480
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEV 480
Query: 481 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 540
AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK
Sbjct: 481 AELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQK 540
Query: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 600
EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS
Sbjct: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 600
Query: 601 KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK
Sbjct: 601 KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL
Sbjct: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
Query: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 780
KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ
Sbjct: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQ 780
Query: 781 GRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 840
GRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE
Sbjct: 781 GRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEE 840
Query: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 900
QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK
Sbjct: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 900
Query: 901 MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 960
MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER
Sbjct: 901 MNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 960
Query: 961 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS
Sbjct: 961 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
Query: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL
Sbjct: 1021 GLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
Query: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL
Sbjct: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
Query: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1200
GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD
Sbjct: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1200
Query: 1201 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1260
AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG
Sbjct: 1201 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1260
Query: 1261 NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDD 1320
NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDD
Sbjct: 1261 NTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDD 1320
Query: 1321 QEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFG 1380
QEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFG
Sbjct: 1321 QEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFG 1380
Query: 1381 HWATNCNDDETF 1392
HWATNCNDDETF
Sbjct: 1381 HWATNCNDDETF 1392
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 2648 bits (6864), Expect = 0.0
Identities = 1392/1427 (97%), Positives = 1392/1427 (97%), Gaps = 35/1427 (2%)
Query: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV
Sbjct: 1 MSMLKPSGLKAPTKILKPGSTALKTPTAVVAPVEKTISSEKASSTPSSETQEEFVDDFRV 60
Query: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR
Sbjct: 61 GERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIFTR 120
Query: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS
Sbjct: 121 PSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTPSNIPQKPSQPAAKEPS 180
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE
Sbjct: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM
Sbjct: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVM 300
Query: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK
Sbjct: 301 ATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEK 360
Query: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA
Sbjct: 361 QQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAA 420
Query: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE------------------------ 456
DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHARIKELEQSLLFEKTKA 480
Query: 457 -----------VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 505
VATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE
Sbjct: 481 DKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE 540
Query: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH
Sbjct: 541 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 600
Query: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ
Sbjct: 601 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 660
Query: 626 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 685
HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT
Sbjct: 661 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT 720
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 745
LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK
Sbjct: 721 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMK 780
Query: 746 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 805
KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK
Sbjct: 781 KLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 840
Query: 806 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 865
ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE
Sbjct: 841 ELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE 900
Query: 866 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN
Sbjct: 901 KDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 960
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER
Sbjct: 961 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 1020
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA
Sbjct: 1021 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1080
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM
Sbjct: 1081 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1140
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1165
EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL
Sbjct: 1141 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLL 1200
Query: 1166 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1225
EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS
Sbjct: 1201 EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1260
Query: 1226 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1285
VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV
Sbjct: 1261 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIV 1320
Query: 1286 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1345
DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE
Sbjct: 1321 DLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTE 1380
Query: 1346 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1392
DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF
Sbjct: 1381 DCPTQAQMSEDPPHSTHHGSRGEERPYCEICEMFGHWATNCNDDETF 1427
>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
[Homo sapiens]
Length = 1011
Score = 786 bits (2029), Expect = 0.0
Identities = 462/1080 (42%), Positives = 672/1080 (62%), Gaps = 96/1080 (8%)
Query: 3 MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48
M KPSGLK P + K S +T T AV A ++ K SS PSS
Sbjct: 1 MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
Query: 49 ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
E ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 61 PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
Query: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
DG+V GVRYF+C L+GIFTRPSKLTR+ AE + + + A + S S ++
Sbjct: 121 DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
Query: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
P T IP + S +++ KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 178 PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
Query: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV
Sbjct: 227 VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
Query: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339
+IGFPST+PAKAK + MA ++L SPS+SS+SS+SSVASSV RPSR+GLLTET
Sbjct: 287 RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
Query: 340 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399
SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL + H
Sbjct: 344 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
Query: 400 DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVAT 459
+Q+V E E K+ + R +VE+ +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE+ T
Sbjct: 404 EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTT 463
Query: 460 VSEKSRIMELEKDLALRVQEVAELRR-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 518
V+EKSR+++LE++L LR E+ EL++ L S P D + +L+ L+E+L
Sbjct: 464 VAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILR----LRERLLSASK 519
Query: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
+HQRE L++ + + +Q E+ L A EK ++E LK K++ A EN ++ WK
Sbjct: 520 EHQRESGVLRDKYEKALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWK 579
Query: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638
SKL++ + HQ+++E+LK + + G G + E ELK +E +++++Q E+ NLQ + D E
Sbjct: 580 SKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLE 639
Query: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
A H KE EALR KL + +E R++L+ QH +E+++ ++ ++AE++V E
Sbjct: 640 TAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHE 699
Query: 699 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI 758
LE L + Q + I+ Q+ E+K+LD + L++A ++GK E++ LR++L AE ++
Sbjct: 700 LEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRL 759
Query: 759 KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS 818
+ + E+ +S T ++ ++ E + KET+E
Sbjct: 760 QAV------EALCSSQHTHMIESNDIS--------EETIRTKETVE-------------- 791
Query: 819 EEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
+Q+ KL++++++ L+S E LR ++ +E+K + +++ + L+K K
Sbjct: 792 --------GLQD---KLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKR 840
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
+LE ++ + + + D S QL ++ EL KER + EL++ L +AN ++ ++ +
Sbjct: 841 RLEAELETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVH 900
Query: 939 KAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEIL 998
KAE +E +K +++ + L KL+ L+K+ S + RY + + L
Sbjct: 901 KAEWRIKE--QKLKDDIRGLREKLTGLDKEKSLSDQR------RYSLIDPSSAPE----L 948
Query: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058
LQ L+ TED L+ A ++ + + +E +R DKA+ + A I +Q +K E
Sbjct: 949 LRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1008
Score = 81.3 bits (199), Expect = 6e-15
Identities = 150/746 (20%), Positives = 309/746 (41%), Gaps = 124/746 (16%)
Query: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-GLGTETAEFAELK----T 615
+K + + V AL S ++I+S + S+ GL TET+ K T
Sbjct: 296 AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT 355
Query: 616 QIEKMRLDYQHEIENLQNQQDSERAAHAK----------EMEALRAKLMKVIKEKENSLE 665
+++ + Q IE L ++D ERA AK E+ L+A+ + + E E L+
Sbjct: 356 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
Query: 666 AIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 725
R ++ + + D N+L+E KV++L Q + E++ + A +
Sbjct: 416 RARLLVESVRKEKV----DLSNQLEEERRKVEDL---QFRVEEESITKGDLELTTVAEKS 468
Query: 726 KLLDLDALRKASSEGKSEMKKLRQQL-----------EAAE-KQIKHLEIEKNAESSKAS 773
++L L+ + + + E+++L+Q L +AAE +++ + + E + S
Sbjct: 469 RVLQLE---EELTLRRGEIEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRES 525
Query: 774 SITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN 833
+ R+ + LK Q + ++ E +E+ LK+K +A+ E + + + + ++
Sbjct: 526 GVLRDKYEKALKA--YQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLD 583
Query: 834 KL---HQK----------------EEQFNMLSSDLEKLREN----LADMEAKF------- 863
L HQK +++ L + +E ++ L +++AK
Sbjct: 584 SLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMH 643
Query: 864 -REKDEREEQLIKAKEKL----ENDIAEIMKMSGDNSSQLTKMNDELR---LKERDVEEL 915
+EK+ E+L +A+E+L + A++ + + +L + D+ R L+ ++E+L
Sbjct: 644 VKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKL 703
Query: 916 QLKLTKANENASFLQK--SIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSH 973
++ + FL++ S+ + + + Q A + ++E + L KL E +++
Sbjct: 704 DVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAVE 763
Query: 974 NQCQELKARYERAT--SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
C + SE + +E ++ LQ DKL +E + L + E LR
Sbjct: 764 ALCSSQHTHMIESNDISEETIRTKETVEGLQ-------DKLNKRDKEVTALTSQTEMLRA 816
Query: 1032 QAD----KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKN 1087
Q K K+ + DA+ KEK A LE + +L + + L+
Sbjct: 817 QVSALESKCKSGEKKVDAL------LKEKRRLEAELETVSRKTHDASGQLVLISQELLRK 870
Query: 1088 VEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
LN+ + LL N+ +++ A + ++ KL +++ R+++
Sbjct: 871 ERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--------QKLKDDIRGLREKL 922
Query: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLR 1207
T L++E+S L ++R S + E LQ + T L + + +++
Sbjct: 923 TG---LDKEKS------LSDQRRYSLIDPSSAPELLRLQHQLMSTEDALRDALDQAQQVE 973
Query: 1208 NEVTVLR---------GENASAKSLH 1224
+ +R G + SA +H
Sbjct: 974 KLMEAMRSCPDKAQTIGNSGSANGIH 999
Score = 58.5 bits (140), Expect = 4e-08
Identities = 92/411 (22%), Positives = 183/411 (44%), Gaps = 64/411 (15%)
Query: 945 QEAAKKHEEEKKEL--ERKLSDLEKKMETSH-----NQCQELKARYERATSETKTKHEE- 996
QEA K+ ++ ++L ER L E TSH + LKA++E+ +E + K +
Sbjct: 358 QEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQRA 417
Query: 997 --ILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQM 1052
++++++K +D ++L+ R + L +EE + AE + +Q+ E++
Sbjct: 418 RLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLELTTVAEKSRVLQLEEEL 477
Query: 1053 TKEKTETLASLEDTKQT---------NAKLQNELDTLKENNLKNVEELNKSKELLTVENQ 1103
T + E +E+ +Q + E+ L+E L +E + +L + +
Sbjct: 478 TLRRGE----IEELQQCLLHSGPPPPDHPDAAEILRLRERLLSASKEHQRESGVLRDKYE 533
Query: 1104 K-MEEFRKEIETLKQAAAQKSQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-L 1153
K ++ ++ E++ L+ A + +Q+++ L++ EN+ L + D + S HQK L
Sbjct: 534 KALKAYQAEVDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSL 593
Query: 1154 EEERSVLNN-------QLLEMKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEK 1205
E+ ++ LN+ ++ E+K + E +LQ + +A+ + EK+A EK
Sbjct: 594 EDLKATLNSGPGAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREK 653
Query: 1206 LRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQ 1265
L+ L G +Q +++++ LELQ +++R+ + + +
Sbjct: 654 LQEAQEELAG-----------LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEK 702
Query: 1266 ADEDERAQESQIDFLNSVI----------VDLQRKNQDLKMKVEMMSEAAL 1306
D + R Q I+FL I LQR K +VE + E L
Sbjct: 703 LDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 753
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 768 bits (1983), Expect = 0.0
Identities = 462/1115 (41%), Positives = 672/1115 (60%), Gaps = 131/1115 (11%)
Query: 3 MLKPSGLKAPTKILKPGSTALKTPT-------AVVAPVEKTISSEKASSTPSS------- 48
M KPSGLK P + K S +T T AV A ++ K SS PSS
Sbjct: 1 MQKPSGLKPPGRGGKHSSPMGRTSTGSASSSAAVAASSKEGSPLHKQSSGPSSSPAAAAA 60
Query: 49 ---------ETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKN 99
E ++F+ DF VGERVWVNG KPG +Q+LGETQFAPGQWAG+VLD+P+GKN
Sbjct: 61 PEKPGPKAAEVGDDFLGDFVVGERVWVNGVKPGVVQYLGETQFAPGQWAGVVLDDPVGKN 120
Query: 100 DGSVAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSS 159
DG+V GVRYF+C L+GIFTRPSKLTR+ AE + + + A + S S ++
Sbjct: 121 DGAVGGVRYFECPALQGIFTRPSKLTRQPTAEGSGSDAHSVESLTAQN---LSLHSGTAT 177
Query: 160 SPSTPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVL 219
P T IP + S +++ KT +ES SNLS++GS+K+GE++L++GDRVL
Sbjct: 178 PPLTSRVIPLRESV-----------LNSSVKTGNESGSNLSDSGSVKRGEKDLRLGDRVL 226
Query: 220 VGGTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVT 279
VGGTK GVVR++GETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQC PK+GLFAP+HKV
Sbjct: 227 VGGTKTGVVRYVGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCPPKFGLFAPIHKVI 286
Query: 280 KIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTET 339
+IGFPST+PAKAK + MA ++L SPS+SS+SS+SSVASSV RPSR+GLLTET
Sbjct: 287 RIGFPSTSPAKAKKT---KRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTET 343
Query: 340 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGH 399
SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSH+ E+E+E+AL + H
Sbjct: 344 SSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQH 403
Query: 400 DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLE--- 456
+Q+V E E K+ + R +VE+ +EKV+L NQLEEE+RKVEDLQFRVEEESITKGDLE
Sbjct: 404 EQYVAEAEEKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQT 463
Query: 457 --------------------------------VATVSEKSRIMELEKDLALRVQEVAELR 484
+ TV+EKSR+++LE++L LR E+ EL+
Sbjct: 464 QLEHARIGELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQ 523
Query: 485 R-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIK 543
+ L S P D + +L+ L+E+L +HQRE L++ + + +Q E+
Sbjct: 524 QCLLHSGPPPPDHPDAAEILR----LRERLLSASKEHQRESGVLRDKYEKALKAYQAEVD 579
Query: 544 ALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL 603
L A EK ++E LK K++ A EN ++ WKSKL++ + HQ+++E+LK + + G
Sbjct: 580 KLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGP 639
Query: 604 GTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENS 663
G + E ELK +E +++++Q E+ NLQ + D E A H KE EALR KL + +E
Sbjct: 640 GAQQKEIGELKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGL 699
Query: 664 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 723
R++L+ QH +E+++ ++ ++AE++V ELE L + Q + I+ Q+
Sbjct: 700 QRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLA 759
Query: 724 EEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 783
E+K+LD + L++A ++GK E++ LR++L AE +++ + E+ +S T ++ +
Sbjct: 760 EKKMLDYERLQRAEAQGKQEVESLREKLLVAENRLQAV------EALCSSQHTHMIESND 813
Query: 784 LKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFN 843
+ E + KET+E +Q+ KL++++++
Sbjct: 814 IS--------EETIRTKETVE----------------------GLQD---KLNKRDKEVT 840
Query: 844 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903
L+S E LR ++ +E+K + +++ + L+K K +LE ++ + + + D S QL ++
Sbjct: 841 ALTSQTEMLRAQVSALESKCKSGEKKVDALLKEKRRLEAELETVSRKTHDASGQLVLISQ 900
Query: 904 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963
EL KER + EL++ L +AN ++ ++ + KAE +E +K +++ + L KL+
Sbjct: 901 ELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWRIKE--QKLKDDIRGLREKLT 958
Query: 964 DLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLL 1023
L+K+ S + RY + + L LQ L+ TED L+ A ++ +
Sbjct: 959 GLDKEKSLSDQR------RYSLIDPSSAPE----LLRLQHQLMSTEDALRDALDQAQQVE 1008
Query: 1024 QELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058
+ +E +R DKA+ + A I +Q +K E
Sbjct: 1009 KLMEAMRSCPDKAQTIGNSGSANGIHQQDKAQKQE 1043
Score = 81.6 bits (200), Expect = 5e-15
Identities = 151/771 (19%), Positives = 311/771 (40%), Gaps = 139/771 (18%)
Query: 561 SKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK-GLGTETAEFAELK----T 615
+K + + V AL S ++I+S + S+ GL TET+ K T
Sbjct: 296 AKAKKTKRMAMGVSALTHSPSSSSISSVSSVASSVGGRPSRSGLLTETSSRYARKISGTT 355
Query: 616 QIEKMRLDYQHEIENLQNQQDSERAAHAK----------EMEALRAKLMKVIKEKENSLE 665
+++ + Q IE L ++D ERA AK E+ L+A+ + + E E L+
Sbjct: 356 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAEEKLQ 415
Query: 666 AIRSKLDKAEDQHLV---EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL-- 720
R ++ + + ++E+ K+++ + +V+E + + QT++ +L
Sbjct: 416 RARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEESITKGDLETQTQLEHARIGELEQ 475
Query: 721 -----KATEEKLL-DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE------------ 762
KA E+LL +L R + KS + +L ++L +I+ L+
Sbjct: 476 SLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEELTLRRGEIEELQQCLLHSGPPPPD 535
Query: 763 --------------IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 808
+ + E + S + R+ + LK Q + ++ E +E+
Sbjct: 536 HPDAAEILRLRERLLSASKEHQRESGVLRDKYEKALKA--YQAEVDKLRAANEKYAQEVA 593
Query: 809 ILKEKFAEASEEAVSVQRSMQETVNKL---HQK----------------EEQFNMLSSDL 849
LK+K +A+ E + + + + ++ L HQK +++ L + +
Sbjct: 594 GLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGELKAVM 653
Query: 850 EKLREN----LADMEAKF--------REKDEREEQLIKAKEKL----ENDIAEIMKMSGD 893
E ++ L +++AK +EK+ E+L +A+E+L + A++ +
Sbjct: 654 EGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAGLQRHWRAQLEVQASQ 713
Query: 894 NSSQLTKMNDELR---LKERDVEELQLKLTKANENASFLQK--SIEDMTVKAEQSQQEAA 948
+ +L + D+ R L+ ++E+L ++ + FL++ S+ + + + Q A
Sbjct: 714 HRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQISLAEKKMLDYERLQRAE 773
Query: 949 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT--SETKTKHEEILQNLQKTLL 1006
+ ++E + L KL E +++ C + SE + +E ++ LQ
Sbjct: 774 AQGKQEVESLREKLLVAENRLQAVEALCSSQHTHMIESNDISEETIRTKETVEGLQ---- 829
Query: 1007 DTEDKLKGAREENSGLLQELEELRKQAD----KAKAAQTAEDAMQIMEQMTKEKTETLAS 1062
DKL +E + L + E LR Q K K+ + DA+ KEK A
Sbjct: 830 ---DKLNKRDKEVTALTSQTEMLRAQVSALESKCKSGEKKVDAL------LKEKRRLEAE 880
Query: 1063 LEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
LE + +L + + L+ LN+ + LL N+ +++ A +
Sbjct: 881 LETVSRKTHDASGQLVLISQELLRKERSLNELRVLLLEANRHSPGPERDLSREVHKAEWR 940
Query: 1123 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
++ KL +++ R+++T L++E+S L ++R S + E
Sbjct: 941 IKE--------QKLKDDIRGLREKLTG---LDKEKS------LSDQRRYSLIDPSSAPEL 983
Query: 1183 ASLQKSISITSALLTEKDAELEKLRNEVTVLR---------GENASAKSLH 1224
LQ + T L + + +++ + +R G + SA +H
Sbjct: 984 LRLQHQLMSTEDALRDALDQAQQVEKLMEAMRSCPDKAQTIGNSGSANGIH 1034
Score = 61.2 bits (147), Expect = 7e-09
Identities = 98/451 (21%), Positives = 197/451 (43%), Gaps = 54/451 (11%)
Query: 896 SQLTKMNDELRLKERDVEEL-------QLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
S T + + L+ K++ +E+L + ++ KA + ++K I + + EQ EA
Sbjct: 352 SGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHICEVEKEIALLKAQHEQYVAEAE 411
Query: 949 KKHEEEK---KELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTL 1005
+K + + + + ++ DL ++E + ++L+ R E S TK E Q +
Sbjct: 412 EKLQRARLLVESVRKEKVDLSNQLEEERRKVEDLQFRVEEE-SITKGDLETQTQLEHARI 470
Query: 1006 LDTEDKLKGAREENSGLLQELEE--LRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063
+ E L + + LL+EL + L A+K++ Q E+ + + +E + L
Sbjct: 471 GELEQSLLLEKAQAERLLRELADNRLTTVAEKSRVLQLEEE-LTLRRGEIEELQQCLLHS 529
Query: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQAAAQK 1122
+ E+ L+E L +E + +L + +K ++ ++ E++ L+ A +
Sbjct: 530 GPPPPDHPDAA-EILRLRERLLSASKEHQRESGVLRDKYEKALKAYQAEVDKLRAANEKY 588
Query: 1123 SQQLSALQE-------ENVKLAEELGRSRDEVTS-HQK-LEEERSVLNN-------QLLE 1166
+Q+++ L++ EN+ L + D + S HQK LE+ ++ LN+ ++ E
Sbjct: 589 AQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNSGPGAQQKEIGE 648
Query: 1167 MKKRESKFIKDADEEKASLQKSISITSAL-LTEKDAELEKLRNEVTVLRGENASAKSLHS 1225
+K + E +LQ + +A+ + EK+A EKL+ L G
Sbjct: 649 LKAVMEGIKMEHQLELGNLQAKHDLETAMHVKEKEALREKLQEAQEELAG---------- 698
Query: 1226 VVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVI- 1284
+Q +++++ LELQ +++R+ + + + D + R Q I+FL I
Sbjct: 699 -LQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQAQAIEFLKEQIS 757
Query: 1285 ---------VDLQRKNQDLKMKVEMMSEAAL 1306
LQR K +VE + E L
Sbjct: 758 LAEKKMLDYERLQRAEAQGKQEVESLREKLL 788
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 193 bits (490), Expect = 1e-48
Identities = 217/995 (21%), Positives = 443/995 (44%), Gaps = 97/995 (9%)
Query: 351 TALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKM 410
T ++ L+E ++ +QLL E+++ ++ T E E+ A ELE +
Sbjct: 869 TKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ----ELEEIL 924
Query: 411 DQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE 470
L + VE + L N+ ++ + ++DL+ +++EE + L++ V+ +++I ++E
Sbjct: 925 HDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKME 984
Query: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH 530
+++ L + ++ + E + S L E + L R + I+ L+E
Sbjct: 985 EEILLLEDQNSKFIK--EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
E+T Q E E K KL+ + D IA +++++ +
Sbjct: 1043 LKKEEKTRQ---------------ELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAK 1087
Query: 591 AMEELKVSFSKGLGTETAE-------FAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
EEL+ + ++G ET EL+ QI +++ D++ E + +N+ + ++ +
Sbjct: 1088 KEEELQGALARG-DDETLHKNNALKVVRELQAQIAELQEDFESE-KASRNKAEKQKRDLS 1145
Query: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTL-NKLQEAEIKVKELEVL 702
+E+EAL+ +L E A + +L +Q + E++ L + + E +++++
Sbjct: 1146 EELEALKTEL-----EDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQR 1200
Query: 703 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762
A E+ + KA EK + L + E E+K L+Q +E + K L+
Sbjct: 1201 HATALEELSEQLEQAKRFKANLEK--NKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 763 IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAV 822
+ +K S R K + LQ L VS + E EK K + +++A
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK-------KGIKFAKDAA 1311
Query: 823 SVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
S++ +Q+T L ++ Q LSS + +L E ++ + E++E + L K L++
Sbjct: 1312 SLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQS 1371
Query: 883 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL-------TKANENASFLQKSIED 935
+A+ K D+ + + + + +D E L +L K + + LQ+ ++D
Sbjct: 1372 QLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDD 1431
Query: 936 MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHE 995
+TV + Q++ A E+++K+ ++ L++ EK + + E + R E E +TK
Sbjct: 1432 LTVDLDH-QRQVASNLEKKQKKFDQLLAE-EKSISARY---AEERDRAEAEAREKETKAL 1486
Query: 996 EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK-AKAAQTAEDAMQIMEQMTK 1054
+ + L++ L E+ +N L ++E+L D K E + + +EQ +
Sbjct: 1487 SLARALEEALEAKEE----FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVE 1542
Query: 1055 EKTETLASLED----TKQTNAKLQNELDTLK---ENNLKNVEELNKSKELLTVENQKMEE 1107
E L LED T+ +L+ + +K E +L+ +E N+ K+ L ++ + E
Sbjct: 1543 EMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELE 1602
Query: 1108 FRKEIETLKQAAAQKSQ------------QLSALQEENVKLAEELGRSRDEVTSHQKLEE 1155
E E ++A A S+ Q+ A + ++ ++L + + ++ +Q+ E
Sbjct: 1603 AELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 1156 ERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRG 1215
E +++ K K +K + E LQ+ ++ + + E ++L +E+T
Sbjct: 1663 EARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEIT---- 1718
Query: 1216 ENASAKSLHSVVQTLESDKVKLELKVKNLELQLKE---NKRQLSSSSGNTDTQAD---ED 1269
+AS KS L +K +LE ++ LE +L+E N L+ T Q D +
Sbjct: 1719 NSASGKS------ALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE 1772
Query: 1270 ERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
A+ S ++ L+R+N++LK K++ + A
Sbjct: 1773 LAAERSAAQKSDNARQQLERQNKELKAKLQELEGA 1807
Score = 164 bits (414), Expect = 7e-40
Identities = 224/1091 (20%), Positives = 467/1091 (42%), Gaps = 143/1091 (13%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERA-------EVAKATSHVGE 387
+L + SR + LQ K+ Q HI+ L + D E E A + + +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVE--AADREKVELLNQLEEEKR-KVEDLQFR 444
+E+E+ L D + + + E + D++ A + EK + L ++ ++ + DL+ R
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 445 VEEESITKGDLEVA-------TVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVD 497
+++E T+ +LE A T + +I EL+ + ++A+ L+ GD D
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD-D 1101
Query: 498 MSL---SLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE---- 550
+L + L+ + LQ ++ + D + E S + + + + E++AL T E
Sbjct: 1102 ETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSE-ELEALKTELEDTLD 1160
Query: 551 ----------KLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK---- 596
K +E LK LE K + I + + TA+ + +E+ K
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 597 --VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLM 654
+GL T+ E A +++++ + +H+ + L + Q E A E + LR +L
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL-DAQVQELHAKVSEGDRLRVELA 1279
Query: 655 KVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVID 714
+ + +N L+ + + L++AE + + +D A +L+ Q E+T+
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKD-------AASLESQLQDTQELLQEETRQKL 1332
Query: 715 NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASS 774
N +S+++ EE + ++L++ E + K L +Q+ A + Q+ + + + + S
Sbjct: 1333 NLSSRIRQLEE---EKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIES 1389
Query: 775 ITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 834
L+ + KL E LS+ + K +L+ K + + ++ ++ +
Sbjct: 1390 ----LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASN 1445
Query: 835 LHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDERE-------EQLIKAKEKLEN- 882
L +K+++F+ L ++ + + A+ EA+ REK+ + E+ ++AKE+ E
Sbjct: 1446 LEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQ 1505
Query: 883 ------DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK------ANENASF-L 929
D+ ++M D + ++ R E+ VEE++ +L + A E+A L
Sbjct: 1506 NKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565
Query: 930 QKSIEDMTVKAEQSQQEAAKKHEEEKK-------ELERKLSDLEKK--METSHNQCQELK 980
+ +++ M + E+ Q +++EE+K+ ELE +L D K+ + + + E+
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625
Query: 981 ARYERATSETKTK-HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA- 1038
+ A E K +E+++ L+K +D +ELEE R D+ A
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKD-----------YQRELEEARASRDEIFAQ 1674
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLE----DTKQTNAKLQNELDTLKENNLKNVEELNKS 1094
++ +E ++ +E + E LAS E +Q +L +E+ ++E +
Sbjct: 1675 SKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRL 1734
Query: 1095 KELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLE 1154
+ + +++EE + +E L + + Q+ L N +LA E ++ + Q+LE
Sbjct: 1735 EARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTL---NAELAAERSAAQKSDNARQQLE 1791
Query: 1155 EERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE-KLRNEVTVL 1213
+ L +L E++ K+ + +IS A + + + +LE + +
Sbjct: 1792 RQNKELKAKLQELE----------GAVKSKFKATISALEAKIGQLEEQLEQEAKERAAAN 1841
Query: 1214 RGENASAKSLHSVVQTLESDKVKLELKVKNLE---LQLKENKRQLSSSSGNTDTQADEDE 1270
+ + K L + +E ++ + + +E ++K+ KRQL + T+A+
Sbjct: 1842 KLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEA-TRANASR 1900
Query: 1271 RAQESQIDFLNSVIVDLQRKNQDLKMKVEM-----------------MSEAALNGNGDDL 1313
R + ++D L R+ LK ++ + A+L + DD
Sbjct: 1901 RKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDT 1960
Query: 1314 NNYDSDDQEKQ 1324
+ SD E Q
Sbjct: 1961 ESKTSDVNETQ 1971
Score = 162 bits (410), Expect = 2e-39
Identities = 199/1005 (19%), Positives = 435/1005 (43%), Gaps = 79/1005 (7%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
+ T L E AR + L+E L + + +E+ + + E K +H+ ++E+
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 391 ELALARDGHDQHVLE---LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
+L + LE EAK+ ++ + + + + + + + + ++ + ++ E
Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 507
E +L A + K +M DL R+++ + R+ LE K D + + L +I+
Sbjct: 1018 EEEKAKNL--AKIRNKQEVM--ISDLEERLKKEEKTRQELEKAKRKLDGE-TTDLQDQIA 1072
Query: 508 SLQEKLEVTRTDHQREITSLKEHF--GAREETHQ----KEIKALYTATEKLSKENESLKS 561
LQ +++ + ++ L+ G E H+ K ++ L +L ++ ES K+
Sbjct: 1073 ELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKA 1132
Query: 562 KLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 621
A K+ D+ + +E LK L T A+ +++R
Sbjct: 1133 SRNKAEKQKRDL---------------SEELEALKTELEDTLDTTAAQ--------QELR 1169
Query: 622 LDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVE 681
+ E+ L+ + E H +++ +R + ++E LE ++K KA + +
Sbjct: 1170 TKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLE--QAKRFKANLEKNKQ 1227
Query: 682 MEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL--KATEEKLLDLDALRKASSE 739
+T NK E+KV L+ ++A+ + K +D +L K +E L ++ KA S+
Sbjct: 1228 GLETDNKELACEVKV--LQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA-SK 1284
Query: 740 GKSEMKKLRQQLEAAEKQIKHLEIEKNAES--SKASSITRELQGRELKLTNLQENLSEVS 797
++E+ + LE AEK K ++ K+A S S+ LQ + NL + ++
Sbjct: 1285 LQNELDNVSTLLEEAEK--KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342
Query: 798 QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLA 857
+ K +L+++ + +E ++ +++Q + +T K+ L +KL ++
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAE 1402
Query: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEI------MKMSGDNSSQLTKMNDELRLKERD 911
+ + EK ++L K K +L+ ++ ++ + N + K D+L +E+
Sbjct: 1403 ALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS 1462
Query: 912 VEELQLKLTKANENASFLQKSIEDMTV-KAEQSQQEAAKKHEEEKKELERKLSDLEKKME 970
+ + + A +K + +++ +A + EA ++ E + K+L + DL +
Sbjct: 1463 ISARYAE-ERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD 1521
Query: 971 TSHNQCQEL---KARYERATSETKTKHEEILQNLQKT---LLDTEDKLKGAREENSGLLQ 1024
EL K E+ E +T+ EE+ LQ T L E ++ + + LQ
Sbjct: 1522 DVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQ 1581
Query: 1025 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1084
+E ++ + Q E + +E K++ +AS + + L+ +++ +
Sbjct: 1582 TRDEQNEEKKRLLIKQVRELEAE-LEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 1085 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1144
+ +++L K + + +++EE R + + + + ++L +L+ E ++L EEL S
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700
Query: 1145 DEVTSHQKLEEERSVLNNQ----------LLEMKKRESKFIKDADEEKASLQKSISITSA 1194
+ + E+ER L ++ LL+ K+R I +EE Q ++ + +
Sbjct: 1701 ---RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLND 1757
Query: 1195 LLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254
+ +++ L E L E ++A+ + Q LE +L+ K++ LE +K +
Sbjct: 1758 RFRKTTLQVDTLNAE---LAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKA 1814
Query: 1255 LSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
S+ Q +E + + N ++ ++K +++ M+VE
Sbjct: 1815 TISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE 1859
Score = 137 bits (345), Expect = 7e-32
Identities = 144/680 (21%), Positives = 321/680 (47%), Gaps = 70/680 (10%)
Query: 675 EDQHLVEMEDTLNKLQEAEIKVK-ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDAL 733
+++ L ++ L K++E + KV+ ELE ++ K + + + QL+A E + + +
Sbjct: 850 QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM 909
Query: 734 RKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKNAESSKASSITRELQGRELKLTNL 789
R + K E++++ LE+ E++ + L+ EK + + +L E L
Sbjct: 910 RARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKL 969
Query: 790 Q-ENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Q E ++ +++K+ +E+E+ +L+++ ++ +E ++ + E ++L ++EE+ L+
Sbjct: 970 QLEKVTAEAKIKK-MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKI 1028
Query: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
K ++D+E + +++++ ++L KAK KL+ + ++ + +Q+ ++ +L K
Sbjct: 1029 RNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKK 1088
Query: 909 ERDVEELQLKLTKANE------NASFLQKSIEDMTVKAE---QSQQEAAKKHEEEKKELE 959
E EELQ L + ++ NA + + ++ + + +S++ + K E++K++L
Sbjct: 1089 E---EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLS 1145
Query: 960 RKL----SDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGA 1015
+L ++LE ++T+ Q QEL+ + E+ +E K EE +N + + D + A
Sbjct: 1146 EELEALKTELEDTLDTTAAQ-QELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204
Query: 1016 REENSGLLQELEELRKQADKAKAAQTAED-----AMQIMEQMTKEKTETLASLE------ 1064
EE S L++ + + +K K ++ +++++Q+ E L+
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 1065 ------------DTKQTNAKLQNELD---TLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
+ + +KLQNELD TL E K + + +K+ ++E+Q +++ +
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK--KGIKFAKDAASLESQ-LQDTQ 1321
Query: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
+ ++ + S ++ L+EE L E+ +E + + LE++ L +QL + KK
Sbjct: 1322 ELLQEETRQKLNLSSRIRQLEEEKNSLQEQ---QEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 1170 R---ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGE----NASAKS 1222
+ + I+ +E K L K S L EK +KL L+ E
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 1223 LHSVVQTLESDKVKLE---LKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDF 1279
V LE + K + + K++ + E + + + + +T+A RA E ++
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 1280 LNSVIVDLQRKNQDLKMKVE 1299
+ +R+N+ L+ +E
Sbjct: 1499 KE----EFERQNKQLRADME 1514
Score = 125 bits (315), Expect = 2e-28
Identities = 146/579 (25%), Positives = 256/579 (44%), Gaps = 62/579 (10%)
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Q+ E E A+ + + + E +L ++ ++ + K L ++LQ E FAE
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 817 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
A E + QE LH ++EE+ +L ++ +K++ ++ D+E + E++
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 870 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
++L + A+ K++ EI+ + NS K E +L E + E +L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNS----KFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
A L K I + +E KK E+ ++ELE+ L+ + +Q EL+A+ +
Sbjct: 1022 AKNLAK-IRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 986 ATSETKTKHEEILQNLQK---TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTA 1042
+ K EE+ L + L + LK RE + + + E+ +++KA +
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDF--ESEKASRNKAE 1138
Query: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL----KNVEELNKSKELL 1098
+ + E++ KTE LEDT T A Q EL T +E + K +EE K+ E
Sbjct: 1139 KQKRDLSEELEALKTE----LEDTLDTTA-AQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 1099 TVENQK-----MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1153
+ ++ +EE +++E K+ A + L+ +N +LA E+ +V K
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEV-----KVLQQVKA 1248
Query: 1154 EEE--RSVLNNQLLEM--KKRESKFIKDADEEKAS-LQKSISITSALLTEKDAELEKLRN 1208
E E R L+ Q+ E+ K E ++ EKAS LQ + S LL E + + K
Sbjct: 1249 ESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAK 1308
Query: 1209 EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADE 1268
+ A SL S +Q D +L + +L L RQL + Q +E
Sbjct: 1309 D----------AASLESQLQ----DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEE 1354
Query: 1269 DERAQ---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
+E A+ E Q+ L S + D ++K D +E + EA
Sbjct: 1355 EEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEA 1393
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 182 bits (463), Expect = 1e-45
Identities = 231/978 (23%), Positives = 431/978 (44%), Gaps = 124/978 (12%)
Query: 352 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARD----------GHDQ 401
+L + E QQ +E ++AE++ + ++ + E ++EL L D
Sbjct: 1047 SLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKN 1106
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVS 461
H ++ E ++ + + + + E QL+E+++++ ++Q + E ++E
Sbjct: 1107 HAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNE 1166
Query: 462 EKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE--------ISSLQEKL 513
K++ + LE R++ +L E K L LQ+ + ++
Sbjct: 1167 LKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226
Query: 514 EVTRTDHQREI----TSLKEHFGAREETHQ--KEIKALYTATEKLSKENESLKSKLEHAN 567
E T + E+ LKEH +E + E A T+ L K + L+ ++ +
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 568 KENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHE 627
+E +++ K ET Q+ M EL++ + ++ A + ++E++RL+
Sbjct: 1287 EE-QELLPNVKEVSET-----QETMNELELLTEQSTTKDSTTLARI--EMERLRLN---- 1334
Query: 628 IENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLN 687
E Q Q+ ++ + KE++N L+ I+ L+ DQ + +TL
Sbjct: 1335 -EKFQESQE---------------EIKSLTKERDN-LKTIKEALEVKHDQLKEHIRETLA 1377
Query: 688 KLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD----ALRKASSEGKSE 743
K+QE++ K ++ ++ K NE TK++ Q K + LL ++ L K E E
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEM-EQFKPKDSALLRIEIEMLGLSKRLQESHDE 1436
Query: 744 MK----------KLRQQLEAAEKQI---------KHLEIEKNAESSKASSITRELQGREL 784
MK +L++ L++ Q+ KHLE E+ + + +E EL
Sbjct: 1437 MKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINEL 1496
Query: 785 KLTNLQENLSEVSQVKETLEKELQILKEKFAE--ASEEAVSVQR--SMQETVNKLHQKEE 840
++ NL E +E+S +++ LE L+ K E EE ++++ +QE VN+L Q +E
Sbjct: 1497 RV-NLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 841 QFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK 900
S L+ + + ++ + +E E + +IK KE+++ + E +++ D + TK
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-VQEALQIERDQLKENTK 1614
Query: 901 MNDELRLKERDVEELQ-LKLTKANE------NASFLQKSIEDMTVKAEQSQQEAAK---- 949
++KE +E Q LK+T NE L++ E + E + E +
Sbjct: 1615 -EIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 950 KHE--EEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEE--ILQNLQKTL 1005
HE EE + + ++ DL ET + +LK + K EE I+ K
Sbjct: 1674 LHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEH 1733
Query: 1006 LDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ--TAEDAMQIMEQMTKEKTETLASL 1063
+T DKL+G E + + +++ + ++ A AQ ++ ++I KE+ ET+ L
Sbjct: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
Query: 1064 ED-TKQTNAKLQNELDTLKENNLKNVEELNKSK----ELLTVENQKMEEFRK--EIETLK 1116
+ KL N L+ +N K E++ + K +L+T++ E +K E+E LK
Sbjct: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
Query: 1117 QAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIK 1176
+ +S LS L+ EN+ LA++L H+ LEE +SV+ + +++ E
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKL---------HENLEEMKSVMKER-DNLRRVEETLKL 1903
Query: 1177 DADEEKASLQ----KSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLES 1232
+ D+ K SLQ + + I L T + L K E E S K++ +
Sbjct: 1904 ERDQLKESLQETKARDLEIQQELKTAR--MLSKEHKETVDKLREKISEKTIQISDIQKDL 1961
Query: 1233 DKVKLELKVKNLELQLKE 1250
DK K EL+ K ELQ KE
Sbjct: 1962 DKSKDELQKKIQELQKKE 1979
Score = 172 bits (435), Expect = 3e-42
Identities = 252/1096 (22%), Positives = 473/1096 (43%), Gaps = 214/1096 (19%)
Query: 388 IEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
IE EL R +D VL+ E QLRT EK E+ +L+E+ DL
Sbjct: 496 IESELNSLRADYDNLVLDYE----QLRT-------EKEEMELKLKEKN----DLDEFEAL 540
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRVQEVA-ELRRRLESNKPAGDVDMSLSLLQEI 506
E TK D E+ + E S + L K + Q++ EL ++E + D + LQE
Sbjct: 541 ERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKED---QIKKLQEY 597
Query: 507 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK--LSKENESLKSKLE 564
Q KLE + D + S+++ ++ E AL E L EN LK K++
Sbjct: 598 IDSQ-KLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMK 656
Query: 565 H---ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKM- 620
K+ + I L++S+LE A ++++V K L + E +L + I+
Sbjct: 657 ELATTYKQMENDIQLYQSQLE--------AKKKMQVDLEKELQSAFNEITKLTSLIDGKV 708
Query: 621 ------RLDYQHEIENLQNQQDSERAAHAKEMEALRAK--LMKVIKEKENSLEAIRSKL- 671
L+ + +I +LQ + + E +E EALR + L+ +K + +E +R ++
Sbjct: 709 PKDLLCNLELEGKITDLQKELNKE----VEENEALREEVILLSELKSLPSEVERLRKEIQ 764
Query: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFT---SQLKATEE--- 725
DK+E+ H++ E +KL +E+ KE V Q E K D+ S K+T++
Sbjct: 765 DKSEELHIITSEK--DKLF-SEVVHKESRV-QGLLEEIGKTKDDLATTQSNYKSTDQEFQ 820
Query: 726 --KLLDLDALRK------ASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
K L +D +K + E+ L ++ + + + L+ E + ++ + TR
Sbjct: 821 NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTR 880
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA---------------- 821
E+Q R ++ L+E L +T+E+E ++ EK + EE
Sbjct: 881 EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQES 940
Query: 822 -------------------VSVQRSMQETVNKLHQKEEQFNMLSSDL-EKLRENL----- 856
+ Q ++ + L Q +E N L S + E++ NL
Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN 1000
Query: 857 ------------------ADMEAK------------------------FREKDERE---E 871
D+EAK +EK+E + E
Sbjct: 1001 TGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLE 1060
Query: 872 QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQK 931
+I KE+L+ D+ E ++M+ +N +L + DEL+ ++ V + + K S
Sbjct: 1061 SVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120
Query: 932 SIEDMTVKAEQSQQEAAKKH------EEEKKELERKLSDLE--------KKMETSHNQ-- 975
+ ++ K ++ Q+ +K +EE E+++K++++E K++ H +
Sbjct: 1121 RLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 976 ----CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG-AREENSGLLQELEELR 1030
Q+L YE S TK + ++L+ LQK+ D L+G RE + LQ EEL+
Sbjct: 1181 RLELAQKLNENYEEVKSITKER--KVLKELQKSFETERDHLRGYIREIEATGLQTKEELK 1238
Query: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN--LKNV 1088
K Q D ++ + EKT + + +D ++++ KLQ E+ L E L NV
Sbjct: 1239 IAHIHLKEHQETIDELR---RSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNV 1295
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETL-KQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
+E+++++E + E+E L +Q+ + S L+ ++ E ++L E+ S++E+
Sbjct: 1296 KEVSETQETM-----------NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEI 1344
Query: 1148 TSHQK-------LEEERSVLNNQLLEMKKRESKFIKDA---DEEKASLQKSISITSALLT 1197
S K ++E V ++QL E + I+++ E+ ++++ + T+ +++
Sbjct: 1345 KSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVS 1404
Query: 1198 E----KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL---QLKE 1250
E K + LR E+ +L G + + H ++++ +K L+ + L+ QLKE
Sbjct: 1405 EMEQFKPKDSALLRIEIEML-GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKE 1463
Query: 1251 NKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNG 1310
N +++ + T+ + + Q + +N + V+L K ++ + L
Sbjct: 1464 NIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIS-----TIQKQLEAIN 1518
Query: 1311 DDLNNYDSDDQEKQSK 1326
D L N + EK+ +
Sbjct: 1519 DKLQNKIQEIYEKEEQ 1534
Score = 146 bits (368), Expect = 2e-34
Identities = 207/1008 (20%), Positives = 450/1008 (44%), Gaps = 86/1008 (8%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDG---HDQHVLELEAK 409
L++ +++K + + + +E+D +EV S V + +E+ +D + + +
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQE 818
Query: 410 MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMEL 469
+T+ +++ +L + E +++ +L ++ + G L+ + + E
Sbjct: 819 FQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEK 878
Query: 470 EKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQ-EISSLQEKLEVTRTDHQREITSLK 528
+++ R+ E+ +L+ +LE+ D +L ++ E + + EKL+ T E+ +L
Sbjct: 879 TREVQERLNEMEQLKEQLENR------DSTLQTVEREKTLITEKLQQTL----EEVKTLT 928
Query: 529 EHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASH 588
+ E+ K+++ E L E + LKS + N D ++ LE+ + H
Sbjct: 929 Q-----EKDDLKQLQ------ESLQIERDQLKSDIHDTVNMNIDTQEQLRNALES-LKQH 976
Query: 589 QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSER------AAH 642
Q+ + LK S+ E + ++ + + ++Q ++ + +QD E A
Sbjct: 977 QETINTLKSKISE----EVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTAD 1032
Query: 643 AKEMEAL--RAKLMKVIKEK---ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVK 697
K+ E + + K+ +I+EK + LE++ ++ ++ + +E T+ +E +
Sbjct: 1033 VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD 1092
Query: 698 ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKK--LRQQLEAAE 755
EL+ Q ++ +L T ++L +++ K S+ E ++ L Q E +E
Sbjct: 1093 ELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSE 1152
Query: 756 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA 815
Q K EIE K +T L+ E + L + L+E + +++ KE ++LKE
Sbjct: 1153 MQKKINEIENLKNELKNKELT--LEHMETERLELAQKLNENYEEVKSITKERKVLKELQK 1210
Query: 816 EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER---EEQ 872
E ++ ++E Q +E+ + L++ +E + ++ EK + +
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD 1270
Query: 873 LIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKS 932
L K+ KL+ +I + + +L E+ + + EL+L ++ S
Sbjct: 1271 LEKSHTKLQEEIPVLHE-----EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLAR 1325
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKT 992
IE ++ + QE+ ++ + KE + L +++ +E H+Q +E E+++
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDN-LKTIKEALEVKHDQLKEHIRETLAKIQESQS 1384
Query: 993 KHEEILQNLQKTLLDTE--DKLKGAREENSGLLQ-ELEELRKQADKAKAAQTAEDAMQIM 1049
K E+ L +K T+ +++ + ++S LL+ E+E L +K Q + D M+
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML----GLSKRLQESHDEMK-- 1438
Query: 1050 EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFR 1109
+ KEK +D ++ LQ+E D LKEN + V + +++E L V + ++E
Sbjct: 1439 -SVAKEK-------DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 1110 KEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKK 1169
+ I L+ ++K ++S +Q++ + ++L E+ + EE+ ++ ++ K
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI---YEKEEQFNIKQISEVQEKV 1547
Query: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
E K K+ + K S +SI LT + L++ + E+ ++ E K + +Q
Sbjct: 1548 NELKQFKEHRKAKDSALQSIESKMLELTNR---LQESQEEIQIMIKEKEEMKRVQEALQ- 1603
Query: 1230 LESDKVK---LELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQ---ESQIDFLNSV 1283
+E D++K E+ K E Q KE + ++ T + E E + E+Q L ++
Sbjct: 1604 IERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENI 1663
Query: 1284 IVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRL 1331
+ R Q L +E M ++ DDL + + + ++ + K L
Sbjct: 1664 ETENIRLTQILHENLEEM--RSVTKERDDLRSVEETLKVERDQLKENL 1709
Score = 139 bits (351), Expect = 1e-32
Identities = 242/1102 (21%), Positives = 457/1102 (41%), Gaps = 223/1102 (20%)
Query: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
LKE+++ I +L R +++ + + I+++L D + E+ K +Q
Sbjct: 1486 LKEQEETINEL-------RVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIK 1538
Query: 417 VEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALR 476
+ +EKV L Q +E RK +D + E + + + E+ +IM EK+ R
Sbjct: 1539 QISEVQEKVNELKQFKEH-RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR 1597
Query: 477 VQEVAELRR-RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 535
VQE ++ R +L+ N M S +E L+ + EI LKE F
Sbjct: 1598 VQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQF---- 1653
Query: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595
ET + ++ + T +L++ ++ KE D+ +S ET Q E L
Sbjct: 1654 ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDL----RSVEETLKVERDQLKENL 1709
Query: 596 KVSFSKGLGTETA------EFAELKTQIEKMR---LDYQHEIENLQ----NQQDSERAAH 642
+ + ++ L + E + I+K+R + +EI N+Q + D+ +A
Sbjct: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 643 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 702
K E LR M +KE++ +++ +R + E D L+ +Q K+LE
Sbjct: 1770 LKIQEELRIAHMH-LKEQQETIDKLRGIVS--------EKTDKLSNMQ------KDLENS 1814
Query: 703 QAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLE 762
AK E+ + +LKA E +L+ L + + SEM++L++Q++ + LE
Sbjct: 1815 NAKLQEKIQ-------ELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 763 IEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAV 822
IE ++ ++L ++ ++ + + +V+ETL+ E LKE E +
Sbjct: 1868 IEN-------LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDL 1920
Query: 823 SVQRSM----------QETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREE 871
+Q+ + +ETV+KL +K + + SD++K L ++ +++ K +E ++E
Sbjct: 1921 EIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKEL 1980
Query: 872 QLIKAKE------KLENDIAEIMK-MSGDNSS---------QLTK----MNDELRLKERD 911
QL++ KE K N++ ++ K N S QLTK +E+R+ ++
Sbjct: 1981 QLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKE 2040
Query: 912 VEEL-QLKLTKANENASFLQKSIEDMTVKAEQSQQ----------------EAAKKHEEE 954
+EL ++K + E F+ ++ +M + Q+ Q E+ ++
Sbjct: 2041 RDELRRIKESLKMERDQFI-ATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSR 2099
Query: 955 KKELERKLS--------------DLEKKMETSHNQCQELKARYERATSETK--------- 991
KEL ++ S DLEK++E +KA +TK
Sbjct: 2100 IKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLFTAN 2159
Query: 992 ----TKHEEILQNLQKTLLDTEDKLKGAREE--NSGLLQELEELRKQADKAKAAQTAEDA 1045
+ I++ L K +L K+K + E N + ++E+ KQ + Q +
Sbjct: 2160 QRCSMEFHRIMKKL-KYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQD 2218
Query: 1046 MQI-----------------MEQMTKEKTET-LASLEDTKQTNAKLQNELDTLKENNLKN 1087
+ +E++ K+ +E+ S++ Q + E+ E L
Sbjct: 2219 CDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNT 2278
Query: 1088 VEELNKSKELLTVENQK---------------MEEFRKEIETLKQAAAQKSQQLSALQEE 1132
++ K K + EN + M E + E + + Q L +L+E+
Sbjct: 2279 RFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEK 2338
Query: 1133 NVKL--------------AEELGRSRDEVTSH------QKLEEERSVLNNQLLEMKK--- 1169
N KL A+ ++D H Q E+ L N L E K+
Sbjct: 2339 NEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAM 2398
Query: 1170 -RESKFIKDADEEKASLQKSISITSALLTEKDAE-------LEKLRNEVTVLRGENA-SA 1220
+ESK IK +QK + +T+ ++ + A+ LEK + + VL+ + A A
Sbjct: 2399 HKESKIIK--------MQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGA 2450
Query: 1221 KSLHSVVQTLESDKVKLEL-KVKNLELQLKENKRQLSSSSGNTDTQ-------ADEDERA 1272
K ++ L+ VK++L K+KN KE ++++S++ + Q + R+
Sbjct: 2451 KPYKEEIEDLKMKLVKIDLEKMKN----AKEFEKEISATKATVEYQKEVIRLLRENLRRS 2506
Query: 1273 QESQIDFLNSVIVDLQRKNQDL 1294
Q++Q + S D Q N+ L
Sbjct: 2507 QQAQDTSVISEHTDPQPSNKPL 2528
Score = 117 bits (293), Expect = 8e-26
Identities = 186/906 (20%), Positives = 380/906 (41%), Gaps = 94/906 (10%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
+QE L+ H+++ D R V++ T + ++++L + + + EL+A Q
Sbjct: 1772 IQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ 1831
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKD 472
L T+ + +N+ +++ ++E L+ +++++S+T LE+ ++ ++ E ++
Sbjct: 1832 LITLKKD--------VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEE 1883
Query: 473 LALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS----LQEKLEVTRT---DHQREIT 525
+ ++E LRR E+ K + D LQE + +Q++L+ R +H+ +
Sbjct: 1884 MKSVMKERDNLRRVEETLKL--ERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVD 1941
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 585
L RE+ +K I+ + + L K + L+ K++ K+ ++ + E
Sbjct: 1942 KL------REKISEKTIQ-ISDIQKDLDKSKDELQKKIQELQKKELQLLRV----KEDVN 1990
Query: 586 ASHQQA--MEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
SH++ ME+LK +F ++ +R+D + L + R A
Sbjct: 1991 MSHKKINEMEQLK-----------KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV-A 2038
Query: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
KE + LR + E++ + +R + + H V+ E L + + E L+
Sbjct: 2039 KERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT----ESLR 2094
Query: 704 AKCNEQTKVIDNFTSQLKATEEKL--LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
KC+ +++ + S++ E L L LD L K K +++ L Q KH
Sbjct: 2095 EKCSRIKELLKRY-SEMDDHYECLNRLSLD-LEKEIEFQKELSMRVKANLSLPYLQTKH- 2151
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEA 821
IEK +++ S+ ++LK LS V+++KE + + + F + E+
Sbjct: 2152 -IEKLFTANQRCSMEFHRIMKKLKYV-----LSYVTKIKEEQHESINKFEMDFIDEVEK- 2204
Query: 822 VSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFRE--KDEREEQLIKAKEK 879
+E + K+ ++ ++ S +L L+ N +M+ E KD E + K +
Sbjct: 2205 ------QKELLIKIQHLQQDCDVPSRELRDLKLN-QNMDLHIEEILKDFSESEFPSIKTE 2257
Query: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVK 939
+ ++ N ++T+ +E D+E+L+ + K N+ + + +
Sbjct: 2258 FQQVLS--------NRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIA 2309
Query: 940 AEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQ 999
E ++ KE E+ L L++K E Q LK T + +
Sbjct: 2310 IMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDN--K 2367
Query: 1000 NLQKTLLDTEDKLKGAREENSGLLQELEE-LRKQADKAKAAQTAEDAMQIMEQMTKEKTE 1058
N T T+ + RE + L + E + K++ K + E I+ ++ + E
Sbjct: 2368 NPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHE 2427
Query: 1059 TLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK-MEEFRKEIETLKQ 1117
+ LE TK+T LQ+++ + + +E+L + +E K +EF KEI K
Sbjct: 2428 SNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATK- 2486
Query: 1118 AAAQKSQQLSALQEENVKLAEE------LGRSRDEVTSHQKLE---EERSVLNNQLLEMK 1168
A + +++ L EN++ +++ + D S++ L V N + L +K
Sbjct: 2487 ATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILK 2546
Query: 1169 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1228
+ K+ + K ++ I + LL+ + L NEV + E + H V
Sbjct: 2547 SEHIRLEKEISKLKQQNEQLIKQKNELLSNN----QHLSNEVKTWK-ERTLKREAHKQVT 2601
Query: 1229 TLESDK 1234
S K
Sbjct: 2602 CENSPK 2607
Score = 99.4 bits (246), Expect = 2e-20
Identities = 174/841 (20%), Positives = 357/841 (42%), Gaps = 112/841 (13%)
Query: 345 RKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVL 404
++I + L+ + ++ Q L E E V K ++ +E+ L L RD + +
Sbjct: 1854 KQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQ 1913
Query: 405 ELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKS 464
E +A+ +++ ++ A +L++ E K V+ L+ ++ E++I D++ K
Sbjct: 1914 ETKARDLEIQQELKTA-----RMLSK--EHKETVDKLREKISEKTIQISDIQKDLDKSKD 1966
Query: 465 RIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 524
EL+K ++QE+ ++ L+ + DV+MS + E+ L+++ E Q
Sbjct: 1967 ---ELQK----KIQELQ--KKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQ--- 2014
Query: 525 TSLKEHFGAREETHQ--KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 582
+ ++F ++ H+ +EI+ + ++L + ESLK + + ++IA + +
Sbjct: 2015 SVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQ 2074
Query: 583 TA-----IASHQQAMEEL---KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQ 634
++ QQ + E K S K L +E + + ++ LD + EIE +
Sbjct: 2075 VKPEKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKEL 2134
Query: 635 QDSERA------AHAKEMEALRA----------KLMKVIKEKENSLEAIRSKLDKAEDQH 678
+A K +E L ++MK +K + + I+ + ++ ++
Sbjct: 2135 SMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF 2194
Query: 679 LVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASS 738
++ D + K +E IK++ L Q C+ ++ + + LK + L ++ + K S
Sbjct: 2195 EMDFIDEVEKQKELLIKIQHL---QQDCDVPSRELRD----LKLNQNMDLHIEEILKDFS 2247
Query: 739 EGK------------SEMKKLRQQLEAAEKQIKHLEIEKNA---ESSKASSITRELQGRE 783
E + S K++ Q LE +E KN E+ + + R
Sbjct: 2248 ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRI 2307
Query: 784 LKLTNLQENLSEVSQ-VKETLEKELQILKEKFAEASEEAVSVQRSMQE--TVNKLHQKEE 840
+ + N E S + + E++L+ LKEK + + +++ S+ VN Q +
Sbjct: 2308 IAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNK 2367
Query: 841 QFNMLSSDLEKLRENLADMEAKFREKDE----REEQLIKAKEKLE--NDIAEIMKMSGDN 894
++ S + E + ++E E E +E ++IK +++LE NDI I K+
Sbjct: 2368 NPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDI--IAKLQA-- 2423
Query: 895 SSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 954
K+++ + E+ E +Q+ K A ++ IED+ +K + E K +E
Sbjct: 2424 -----KVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEF 2478
Query: 955 KKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKG 1014
+KE+ + +E + E + L+ + + ++H + Q K L
Sbjct: 2479 EKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTD-PQPSNKPL--------- 2528
Query: 1015 AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ 1074
SG++Q + L +++ + + Q EQ+ K+K E L++ N L
Sbjct: 2529 TCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSN-------NQHLS 2581
Query: 1075 NELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1134
NE+ T KE LK ++ + +T EN K + A+ +K S +E N+
Sbjct: 2582 NEVKTWKERTLK-----REAHKQVTCENSP-----KSPKVTGTASKKKQITPSQCKERNL 2631
Query: 1135 K 1135
+
Sbjct: 2632 Q 2632
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 175 bits (444), Expect = 2e-43
Identities = 223/1006 (22%), Positives = 457/1006 (45%), Gaps = 132/1006 (13%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 938 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 996
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARD-GHDQ 401
T ++AL+E QQ ++ L AE D L +A++ + G +EQE + D +
Sbjct: 997 TKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAK 1056
Query: 402 HVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVS 461
LE + K+ Q TM + +K +L +L++++ ++ LQ ++E+E L+
Sbjct: 1057 RKLEGDLKLAQESTM--DIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKE 1114
Query: 462 EKSRIMELEKDLALR--------------VQEVAELRRRLE--SNKPAGDVDMSLSLLQE 505
++RI ELE+++ +E+ E+ RLE + ++M+ E
Sbjct: 1115 LQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAE 1174
Query: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK----- 560
++ LE H+ +L++ ++I L +KL KE +K
Sbjct: 1175 FQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDD 1234
Query: 561 --SKLEHANKENSDV---------------------------IALWKSKLETAIASHQQA 591
S +E +K ++ + +++L+T + +
Sbjct: 1235 LASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQ 1294
Query: 592 MEE---LKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDSERAAHAKE 645
++E L S+G T + ELK Q+E K + H +++ ++ D R + +E
Sbjct: 1295 LDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEE 1354
Query: 646 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVKELEVLQA 704
EA +A+L + + + + + R+K + Q E+E+ KL Q + + +E + A
Sbjct: 1355 QEA-KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNA 1413
Query: 705 KCN--EQTK-----VIDNFTSQLKATEEKLLDLDALR----KASSEGKSEMKKLRQQLEA 753
KC E+TK +++ ++ T LD + K +E K + ++ +LEA
Sbjct: 1414 KCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEA 1473
Query: 754 AEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQI 809
++K+ + L E KNA + E RE K NLQ+ +S++++ K +
Sbjct: 1474 SQKESRSLSTELFKIKNAYEESLDQL--ETLKRENK--NLQQEISDLTEQIAEGGKRIHE 1529
Query: 810 LKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
L++ + +E +Q +++E L +E + + +L +++ ++++ K EKDE
Sbjct: 1530 LEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVK---SEVDRKIAEKDEE 1586
Query: 870 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANENA 926
+Q+ + N I + M +++ ND +RLK E D+ E++++L AN A
Sbjct: 1587 IDQMKR------NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 927 SFLQKSIED--MTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984
+ ++ + +K Q + A + +E+ KE +L+ +E++ + +EL+A E
Sbjct: 1641 AEALRNYRNTQAILKDTQLHLDDALRSQEDLKE---QLAMVERRANLLQAEIEELRATLE 1697
Query: 985 RATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQE-LEELRKQAD 1034
+ K +E+L ++ +L++T+ KL+ + G +++ ++E R +
Sbjct: 1698 QTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEE 1757
Query: 1035 KAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKENNLKNVEE 1090
KAK A T DA + E++ KE+ +T A LE K QT LQ+ LD ++ LK ++
Sbjct: 1758 KAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 1091 LNKSKE--LLTVENQKMEEFRKEIETLK--QAAAQKSQQLSALQEEN----VKLAEELGR 1142
+ E + +E + E ++ +E +K + +K ++L+ EE+ ++L + + +
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 1143 SRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
+ +V S+++ EE +N L +R +++A EE+A + +S
Sbjct: 1875 LQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEA-EERADIAES 1919
Score = 155 bits (391), Expect = 3e-37
Identities = 214/1043 (20%), Positives = 431/1043 (41%), Gaps = 142/1043 (13%)
Query: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
+KE+ + ++ LA+ + +R E+ + + + + +L L + + E + DQL
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQL--- 912
Query: 417 VEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALR 476
+ K++L +++E + ED + E + K LE K I +LE LA
Sbjct: 913 ----IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA-- 966
Query: 477 VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE 536
E + NK + L + I+ L ++ + + HQ+ + L +
Sbjct: 967 ---KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL--------Q 1015
Query: 537 THQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIA---------- 586
+ ++ L A KL ++ + L+ LE K D + K KLE +
Sbjct: 1016 AEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD-LERAKRKLEGDLKLAQESTMDIE 1074
Query: 587 -SHQQAMEELKVS--FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
QQ E+LK GL ++ + L Q++K + Q IE L+ + ++ERA+
Sbjct: 1075 NDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERAS-- 1132
Query: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
RAK K + LE I +L++A ++E +NK +EAE + ++ +
Sbjct: 1133 ------RAKAEKQRSDLSRELEEISERLEEAGGATSAQIE--MNKKREAEFQKMRRDLEE 1184
Query: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLD-------ALRKASSEGKSEMKKLRQQLEAAEK 756
A + + E +D L K SE K E+ L +E K
Sbjct: 1185 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSK 1244
Query: 757 QIKHLEIEKNAESSKASSI-TRELQGREL------KLTNLQENLSEVSQ---VKETLEKE 806
+LE A + S I T+E + + L + LQ E S+ K+TL +
Sbjct: 1245 AKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQ 1304
Query: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
L K+ F + EE ++R ++E + D + LRE ++ E+
Sbjct: 1305 LSRGKQAFTQQIEE---LKRQLEEEIKAKSALAHALQSSRHDCDLLRE-------QYEEE 1354
Query: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ERDVEELQLK 918
E + +L +A K +++A+ ++ Q T+ +E + K E VE + K
Sbjct: 1355 QEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 919 LTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQE 978
+ LQ +ED+ + E++ A L++K + +K + +C+E
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACA--------ALDKKQRNFDKILAEWKQKCEE 1466
Query: 979 LKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA 1038
A E + E+++ E+ + ++ ++ D+L+ + EN L QE+ +L +Q A+
Sbjct: 1467 THAELEASQKESRSLSTELFK-IKNAYEESLDQLETLKRENKNLQQEISDLTEQI--AEG 1523
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-ELNKSKEL 1097
+ + +I +Q+ +EK+E A+LE+ + A L++E E + ++ ELN+ K
Sbjct: 1524 GKRIHELEKIKKQVEQEKSELQAALEEAE---ASLEHE-----EGKILRIQLELNQVKSE 1575
Query: 1098 LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER 1157
+ ++K+ E +EI+ +K+ + ++ L E+ D + +K+E +
Sbjct: 1576 V---DRKIAEKDEEIDQMKR------NHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDL 1626
Query: 1158 SVLNNQLLEMKKRESKFIK------------------------DADEEKASLQKSISITS 1193
+ + QL + ++ ++ D E+ A +++ ++
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1194 ALLTEKDAELEKLRNEVTVLRGENASAKS----LHSVVQTLESDKVKLELKVKNLE---- 1245
A + E A LE+ + E A LH+ +L + K KLE + ++
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 1246 --LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+Q N + + + E+ + ++ L + +L++ +DL+ +++ +
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQ 1806
Query: 1304 AALNGNGDDLNNYDSDDQEKQSK 1326
AL G + ++ +E + +
Sbjct: 1807 LALKGGKKQIQKLEARVRELEGE 1829
Score = 148 bits (373), Expect = 4e-35
Identities = 166/785 (21%), Positives = 345/785 (43%), Gaps = 99/785 (12%)
Query: 596 KVSFSKGL-----GTETAEFAELKTQIEKM------RLDYQHEIENLQN----QQDSERA 640
KV F GL + A+L T+ + M R++YQ +E ++ Q +
Sbjct: 766 KVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAF 825
Query: 641 AHAKEMEALRA--KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
+ K ++ K+ ++K E E K E E T +L + E K KE
Sbjct: 826 MNVKHWPWMKLYFKIKPLLKSAETEKEMANMK---------EEFEKTKEELAKTEAKRKE 876
Query: 699 LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAA 754
LE ++ ++ Q++A + L D D L K + ++++K++ ++ E
Sbjct: 877 LEEKMVTLMQEK---NDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDE 933
Query: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814
E+ L +K + S + +++ EL L +++ + L +E+ L E
Sbjct: 934 EEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETI 993
Query: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
A+ ++E ++Q + Q+T++ L +E++ N L+ KL + + D+E ++ + L
Sbjct: 994 AKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
Query: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE 934
+AK KLE D+ + + D + +++++L+ KE ++ LQ K+ LQK I+
Sbjct: 1054 RAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIK 1113
Query: 935 DMTVKAEQSQQE------AAKKHEEEKKELERKLSDLEKKMETS---------HNQCQEL 979
++ + E+ ++E + K E+++ +L R+L ++ +++E + N+ +E
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 980 K-ARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQA----- 1033
+ + R E +HE L+K D+ +L + + Q+LE+ + +
Sbjct: 1174 EFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID 1233
Query: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDT----LKENNLKNVE 1089
D A +T A +E+M + + L+ ++ ++ +L N+L L+ + +
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSAL-------------------- 1129
+L++ L++ ++ + F ++IE LK+ ++ + SAL
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 1130 -QEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1187
QE +L + ++ EV K E + +L E KK+ ++ ++DA+E
Sbjct: 1354 EQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEH------ 1407
Query: 1188 SISITSALLTEKDAELEKLRNEVTVL----RGENASAKSLHSVVQTLESDKVKLELKVKN 1243
+ +A + ++L+NEV L NA+ +L + DK+ E K K
Sbjct: 1408 -VEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF--DKILAEWKQKC 1464
Query: 1244 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
E + Q S S T+ + + A E +D L + L+R+N++L+ ++ ++E
Sbjct: 1465 EETHAELEASQKESRS--LSTELFKIKNAYEESLDQLET----LKRENKNLQQEISDLTE 1518
Query: 1304 AALNG 1308
G
Sbjct: 1519 QIAEG 1523
Score = 144 bits (362), Expect = 8e-34
Identities = 163/839 (19%), Positives = 376/839 (44%), Gaps = 72/839 (8%)
Query: 320 SSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 379
+S A + R + L E S R T+A E K+++ +++ RDLE A +
Sbjct: 1131 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM--RRDLEEATL- 1187
Query: 380 KATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVE 439
+ E A R H V EL ++D L+ + + ++EK E+ K +++
Sbjct: 1188 -------QHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM-------KMEID 1233
Query: 440 DLQFRVEEESITKGDLEV---ATVSEKSRIMELEKDLALRVQEVAELRRRL--ESNKPAG 494
DL +E S KG+LE A + S I E++ + ++ R RL ES + +
Sbjct: 1234 DLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSR 1293
Query: 495 DVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSK 554
+D +L+ ++S ++ + +R++ + A Q E+ +
Sbjct: 1294 QLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEE 1353
Query: 555 ENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGL--GTETAEFAE 612
E E+ K++L+ A + + +A W++K ET + +EE K ++ L E E
Sbjct: 1354 EQEA-KAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 613 LK-TQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 671
K +EK + Q+E+E+L + AA A ++ + K++ E + E ++L
Sbjct: 1413 AKCASLEKTKQRLQNEVEDLMIDVERTNAACAA-LDKKQRNFDKILAEWKQKCEETHAEL 1471
Query: 672 DKAEDQHLVEMEDTLNKLQEA-EIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL 730
+ ++ + + L K++ A E + +LE L+ + + I + T Q+ +++ +L
Sbjct: 1472 EASQKESR-SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL 1530
Query: 731 DALRKASSEGKSEMKKLRQQLEAA----EKQIKHLEIEKNAESSKASSITRELQGRELKL 786
+ ++K + KSE++ ++ EA+ E +I +++E N S+ + R++ ++ ++
Sbjct: 1531 EKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSE---VDRKIAEKDEEI 1587
Query: 787 TNLQEN-LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845
++ N + V ++ TL+ E++ + +A+ +++ M+ +N++ + N +
Sbjct: 1588 DQMKRNHIRIVESMQSTLDAEIR--------SRNDAIRLKKKMEGDLNEMEIQLNHANRM 1639
Query: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
++ E LR N + +A ++ + ++++E L+ +A + + + +++ ++ L
Sbjct: 1640 AA--EALR-NYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATL 1696
Query: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
ER + + +L A+E L S KK E + +++ ++ D+
Sbjct: 1697 EQTERSRKIAEQELLDASERVQLLHTQ--------NTSLINTKKKLETDISQIQGEMEDI 1748
Query: 966 EKKMETSHNQCQE------LKARYERATSETKTKHEEILQNLQKTLLDTEDKL------- 1012
++ + + ++ + A + +T E + +NL++T+ D + +L
Sbjct: 1749 IQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA 1808
Query: 1013 -KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNA 1071
KG +++ L + EL + + + +A++ + + ++ E E+ ++
Sbjct: 1809 LKGGKKQIQKLEARVRELEGEVESEQKRNV--EAVKGLRKHERKVKELTYQTEEDRKNIL 1866
Query: 1072 KLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQ 1130
+LQ+ +D L+ + +++E V K + E+E ++ A Q++ L+
Sbjct: 1867 RLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLR 1925
Score = 99.8 bits (247), Expect = 2e-20
Identities = 117/568 (20%), Positives = 247/568 (43%), Gaps = 56/568 (9%)
Query: 332 RTGLLTETSSRYARKISGTTALQEALKEK-----------QQHIEQLLAERDLERAEVAK 380
RT L E + A+++ EA+ K Q +E L+ + + A A
Sbjct: 1386 RTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAA 1445
Query: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK---VELLNQLEEEKRK 437
++ LA + ++ ELEA + R++ + K E L+QLE KR+
Sbjct: 1446 LDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRE 1505
Query: 438 VEDLQFRVEE--ESITKGDLEVATVSEKSRIMELEKDLALRVQEVAE----------LRR 485
++LQ + + E I +G + + + + +E EK E AE LR
Sbjct: 1506 NKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRI 1565
Query: 486 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 545
+LE N+ +VD ++I+ E+++ + +H R + S++ A + I+
Sbjct: 1566 QLELNQVKSEVD------RKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL- 1618
Query: 546 YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGT 605
+K+ + ++ +L HAN+ ++ + +++ Q +++ ++ L +
Sbjct: 1619 ---KKKMEGDLNEMEIQLNHANRMAAEALRNYRNT--------QAILKDTQLHLDDALRS 1667
Query: 606 ETAEFAELKTQIEKMRLDYQHEIENLQ-NQQDSERAAHAKEMEALRA-KLMKVIKEKENS 663
+ + E +E+ Q EIE L+ + +ER+ E E L A + ++++ + S
Sbjct: 1668 QE-DLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 664 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT 723
L + KL+ Q EMED + + + AE K K+ A E+ K + ++ L+
Sbjct: 1727 LINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1786
Query: 724 EEKLLDL--DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781
++ L D + + +K ++Q++ E +++ LE E +E + + L+
Sbjct: 1787 KKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRK 1846
Query: 782 RELKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNK 834
E K+ L ++N+ + + + L+ +++ K + EA E++ + ++
Sbjct: 1847 HERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHE 1906
Query: 835 LHQKEEQFNMLSSDLEKLRENLADMEAK 862
L + EE+ ++ S + KLR ++ K
Sbjct: 1907 LEEAEERADIAESQVNKLRVKSREVHTK 1934
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 174 bits (442), Expect = 4e-43
Identities = 223/1007 (22%), Positives = 448/1007 (44%), Gaps = 142/1007 (14%)
Query: 295 AVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
A +R + +SLKR L+ ++ V + ++ L+E + IS T +
Sbjct: 942 AKKRNLEDKCSSLKRDIDDLELT-LTKVEKEKHATENKVKNLSEEMTALEENISKLTKEK 1000
Query: 355 EALKEK-QQHIEQLLAERDLER------AEVAKATSHV-GEIEQELALARD-GHDQHVLE 405
++L+E QQ ++ L E D A++ + T + G +EQE L D + LE
Sbjct: 1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLE 1060
Query: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
+ KM Q M D++++E +L++++ ++ LQ ++++E + + ++R
Sbjct: 1061 GDLKMSQESIMDLENDKQQIE--EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQAR 1118
Query: 466 IMELEKDLALR--------------VQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSL 509
I ELE+++ +E+ E+ RLE S + ++M+ E +
Sbjct: 1119 IEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKM 1178
Query: 510 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK-------SK 562
+ LE H+ +L++ ++I L +KL KE LK S
Sbjct: 1179 RRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASN 1238
Query: 563 LEHANKENSDV---------------------------IALWKSKLETA---IASHQQAM 592
+E +K S++ + + K++L+T ++ +
Sbjct: 1239 IEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
Query: 593 EELKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQDSERAAHAKEMEAL 649
E L +K T + ELK Q+E K + H +++ ++ D R + +E EA
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEA- 1357
Query: 650 RAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL----QEAEIKVKELEVLQAK 705
+A+L + + + + + R+K + Q E+E+ KL QEAE + E +K
Sbjct: 1358 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE---ENTETANSK 1414
Query: 706 CN--EQTKV-----IDNFTSQLKATEEKLLDLDALR----KASSEGKSEMKKLRQQLEAA 754
C E+TK +++ L+ + LD + K +E K ++ + + +LEAA
Sbjct: 1415 CASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAA 1474
Query: 755 EKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF 814
+K+ + L E + + +L+ + NLQE +S++++ K LQ ++
Sbjct: 1475 QKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTK 1534
Query: 815 AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLI 874
+E +Q +++E L +E + + +L +++ ++++ K EKDE EQL
Sbjct: 1535 KLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVK---SELDRKVIEKDEEIEQLK 1591
Query: 875 KAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANENASFLQK 931
+ ++ + ++ +++ ND LRLK E D+ E++++L +N + QK
Sbjct: 1592 RNSQRAAEALQSVL------DAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAETQK 1645
Query: 932 SIEDMTVKAEQSQ---QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 988
+ + + + SQ +A + +E +L+ +L+ +E++ + +E+K E+
Sbjct: 1646 HLRTVQGQLKDSQLHLDDALRSNE----DLKEQLAIVERRNGLLLEELEEMKVALEQTER 1701
Query: 989 ETKTKHEE---------ILQNLQKTLLDTEDKLKG------AREENSGLLQELEELRKQA 1033
+ +E +L + +L++T+ KL+ A ENS ++E R
Sbjct: 1702 TRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENS-----IQESRNAE 1756
Query: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKENNL---- 1085
+KAK A T DA + E++ KE+ +T A LE K QT LQ+ LD ++ L
Sbjct: 1757 EKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGK 1813
Query: 1086 KNVEEL-NKSKEL---LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1141
K +++L N+ +EL L VE ++ E K ++ + + Q + ++L + +
Sbjct: 1814 KQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVD 1873
Query: 1142 RSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
+ + +V S+++ EE N L +R +++A E+A + +S
Sbjct: 1874 KLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEA-AERADIAES 1919
Score = 158 bits (400), Expect = 3e-38
Identities = 157/702 (22%), Positives = 314/702 (44%), Gaps = 78/702 (11%)
Query: 657 IKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNF 716
IK S EA + ED + E ++ + E++ K + +LQ K + Q +V +
Sbjct: 840 IKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV-QSE 898
Query: 717 TSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
T L EE+ + L K+ ++++K+L ++LE E+ L +K K SS+
Sbjct: 899 TENLMDAEERC---EGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLK 955
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLH 836
R++ EL LT +++ + L +E+ L+E ++ ++E S+Q + Q+T++ L
Sbjct: 956 RDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQ 1015
Query: 837 QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSS 896
+E++ N L KL + D+E ++ + L +AK KLE D+ + D +
Sbjct: 1016 VEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLEN 1075
Query: 897 QLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKH----- 951
++ ++L+ KE ++ +LQ K+ ++ QK I+++ + E+ ++E +H
Sbjct: 1076 DKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK 1135
Query: 952 -EEEKKELERKLSDLEKKMETSH---------NQCQELK-ARYERATSETKTKHEEILQN 1000
E+++ +L R+L ++ +++E + N+ +E + + R E +HE
Sbjct: 1136 IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 1001 LQKTLLDTEDKL-----------KGAREENSGLLQELEEL--------RKQADKAKAAQT 1041
L+K D+ +L + +E S L E++++ + +++ + +T
Sbjct: 1196 LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRT 1255
Query: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
ED ++ +++T+ + L K EL E + +L KSK+ LT
Sbjct: 1256 VEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT-- 1313
Query: 1102 NQKMEEFRKEIETLKQA------AAQKS--------QQLSALQEENVKLAEELGRSRDEV 1147
Q++EE ++++E +A A Q S +Q QE +L L ++ EV
Sbjct: 1314 -QQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEV 1372
Query: 1148 TS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKL 1206
K E + +L E KK+ ++ +++A+E + + E+E L
Sbjct: 1373 AQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDL 1432
Query: 1207 RNEVTVLRGENASAKSLHSVVQTLES-----DKVKLELKVKNLELQLKENKRQLSSSSGN 1261
++ + H+ TL+ DKV E K K E Q + Q S S
Sbjct: 1433 MRDL----------ERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRS-- 1480
Query: 1262 TDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
T+ + A E +D L + L+R+N++L+ ++ ++E
Sbjct: 1481 LSTELFKMRNAYEEVVDQLET----LRRENKNLQEEISDLTE 1518
Score = 93.6 bits (231), Expect = 1e-18
Identities = 127/599 (21%), Positives = 271/599 (45%), Gaps = 71/599 (11%)
Query: 332 RTGLLTETSSRYARKI-----------SGTTALQEALKEKQQHIEQLLAERDLERAEVAK 380
RT L E + A+++ S +L++ + Q +E L+ RDLER+ A
Sbjct: 1386 RTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLM--RDLERSHTAC 1443
Query: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVED 440
AT L + D+ + E + K+D+ + +EAA +E L +L + + E+
Sbjct: 1444 AT---------LDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEE 1494
Query: 441 LQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSL 500
+ ++E +L+ +I E K+L QE + ++ +E K D+ +
Sbjct: 1495 VVDQLETLRRENKNLQEEISDLTEQIAETGKNL----QEAEKTKKLVEQEKS----DLQV 1546
Query: 501 SLLQEISSLQ-EKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559
+L + SL+ E+ ++ R Q E++ +K + +EI+ L +++ + E+L
Sbjct: 1547 ALEEVEGSLEHEESKILRV--QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAA---EAL 1601
Query: 560 KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
+S L+ + +D + L K K+E + E+++ S ET + L+T +
Sbjct: 1602 QSVLDAEIRSRNDALRL-KKKMEGDLNEM-----EIQLGHSNRQMAETQK--HLRTVQGQ 1653
Query: 620 MRLDYQHEIENLQNQQD-SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQH 678
++ H + L++ +D E+ A + L L++ ++E + +LE + + +Q
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQLAIVERRNGL---LLEELEEMKVALEQTE-RTRRLSEQE 1709
Query: 679 LVEMEDTLNKLQEAEIKV----KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 734
L++ D + L + K+LE A+C + ++N + + EEK +
Sbjct: 1710 LLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAE---VENSIQESRNAEEKA------K 1760
Query: 735 KASSEGKSEMKKLRQQLEAAEKQIKHLE-IEKNAESSKASSITRELQGRELKLTNLQENL 793
KA ++ ++L+++ + + HLE ++KN E + R + +L L ++ +
Sbjct: 1761 KAITDAAMMAEELKKEQDTSA----HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1816
Query: 794 SEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 853
++ LE EL + +++ AEA + A +R ++E + + + L ++KL+
Sbjct: 1817 QKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQ 1876
Query: 854 ENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV 912
+ + + E +E+ + ++++++ E + + SQ+ K LR K RDV
Sbjct: 1877 AKVKSYKRQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNK----LRAKSRDV 1931
Score = 48.9 bits (115), Expect = 3e-05
Identities = 70/327 (21%), Positives = 144/327 (44%), Gaps = 41/327 (12%)
Query: 1022 LLQELEELRKQADKAKAAQT-AEDAMQIMEQMT------KEKTETLAS-LEDTKQTNAKL 1073
L +++ L K A+ K T ED + E++ KE E + S L++ ++
Sbjct: 836 LFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQV 895
Query: 1074 QNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQL----SAL 1129
Q+E + L + + E L KSK LL + +++ E +E E + K + L S+L
Sbjct: 896 QSETENLMDAE-ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL 954
Query: 1130 QEE-------NVKLAEELGRSRDEVTSHQK----LEEERSVLNNQLLEMKKRESKFIKDA 1178
+ + K+ +E + ++V + + LEE S L + +++ + + D
Sbjct: 955 KRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDL 1014
Query: 1179 DEEKASLQKSISITSALLTEKD------AELEKLRNEV-TVLRGENASAKSLHSVVQTLE 1231
E+ + I I + L + D + +KLR ++ R K + LE
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074
Query: 1232 SDKVKLELKVKNLELQLKENKRQLSSSSGNT--------DTQADEDERAQESQIDFLNSV 1283
+DK ++E K+K E +L + + ++ ++ + QA +E E +I+ +++
Sbjct: 1075 NDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEE--LEEEIEAEHTL 1132
Query: 1284 IVDLQRKNQDLKMKVEMMSEAALNGNG 1310
++++ DL ++E +SE +G
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASG 1159
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 174 bits (440), Expect = 7e-43
Identities = 232/1111 (20%), Positives = 479/1111 (43%), Gaps = 161/1111 (14%)
Query: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ--- 390
GL+T++S+ +L++ L+E Q + +DL + A+ + + +I+
Sbjct: 128 GLVTDSSAELQ-------SLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYD 180
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE---------LLNQLEEEKRKVEDL 441
E R+ +Q V L ++++ T+++ E ++ L +L + + ++++
Sbjct: 181 EERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNM 240
Query: 442 QFRVEEESITKGD----LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGD-- 495
E ES D L+ S ++ I +L +LA QEVA + L+ K + +
Sbjct: 241 TLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNEL 300
Query: 496 -------VDMSLSLLQEISSLQEK--------LEVTRTDHQREIT--SLKEHFGAREETH 538
+ L Q+ + L+EK + T HQ+++ L+ A E +
Sbjct: 301 TQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSL 360
Query: 539 QK---EIKALYTATEKLSKENESLKSKLEHANKE------------------NSDVIALW 577
+ E+ AT+KL +E +++K +H E S++ L
Sbjct: 361 HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLH 420
Query: 578 KSKLETAIA---SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIEN---L 631
LET +H + E+ ++S K + E + A+L+ ++ ++ + ++ N L
Sbjct: 421 SKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ-QVADLQLKLSRLEEQLKEKVTNSTEL 479
Query: 632 QNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
Q+Q D + H +E +AL+ ++E +N LE + ++ +DQ + +E L K +E
Sbjct: 480 QHQLDKTKQQH-QEQQALQQSTTAKLREAQNDLEQVLRQIGD-KDQKIQNLEALLQKSKE 537
Query: 692 -AEIKVKELEVLQAKCNE---QTKVIDNFTSQLKATEEKLLDL-DALRKASSEGKSEMKK 746
+ KE E L AK +T V++ + +E++ L + L+ S K +
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 747 LRQQ-------LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQV 799
L Q L AA+ ++ LE N +S+ + ++ ++++ E L
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 800 KET----LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLREN 855
K L+ L + + +E + + + KL K+E + L S L++ +E
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEK 717
Query: 856 LADMEAKFREKDEREEQL------IKA-KEKLENDIAEIMKMSGDNSSQLTKMNDELRL- 907
+E K E + + ++L +KA KE+ D+ + +++ D + T+++ +L +
Sbjct: 718 YLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEME 777
Query: 908 -------------KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEE 954
K +E ++ KLTK E L++ E ++ QE +HEE
Sbjct: 778 KEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLS-------QETKIQHEEL 830
Query: 955 KKELERKLSDLEK-KME-----TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1008
++ +++L+K KME T + ++ ++ + +K++ E+ Q + +LD
Sbjct: 831 NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDL 890
Query: 1009 EDKLKGARE----ENSGLLQELEELRKQADKAKAA------------QTAEDAMQIMEQM 1052
E K + + L+E +EL+K +K K A + A ++Q
Sbjct: 891 EKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQN 950
Query: 1053 TKEKTETLASLEDTKQTNAKLQNELDT----LKENNLKNVEELNKSKELLTVENQKMEEF 1108
KE+ + ++ + KQ++ + + +++ LK L+ E NK ++ LT Q++
Sbjct: 951 EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 1109 RKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMK 1168
+++I L+ + + LQ + EL +R ++ S +EE+ S+ L+ +
Sbjct: 1011 KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS---VEEKLSLAQEDLISNR 1067
Query: 1169 KR---ESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHS 1225
+ ++K I++ KA+L++ + L E+ L+ ++ E ++ E + KS +
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 1226 VVQTL------ESDKVKLELKVKNLE-----LQLKENKRQLSSSSGNTDTQADEDERAQE 1274
++ + E K+ ELK LE LK+ K+ L +AD + A E
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 1275 SQIDFLNSVIVDLQRKNQDLKMKVEMMSEAA 1305
+ N I+ Q K ++ ++K E + + A
Sbjct: 1188 Q--EKRNQQILKDQVKKEEEELKKEFIEKEA 1216
Score = 152 bits (384), Expect = 2e-36
Identities = 197/951 (20%), Positives = 405/951 (42%), Gaps = 162/951 (17%)
Query: 336 LTETSSRYARKISGTTALQEAL-KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
L+ + K++ +T LQ L K KQQH EQ + L+++ AK ++EQ L
Sbjct: 462 LSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQNDLEQVLRQ 517
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVEL-------------LNQLEEE------- 434
D DQ + LEA + + + + ++E+ +L LNQL+E+
Sbjct: 518 IGD-KDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQ 576
Query: 435 ---------------KRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLA----- 474
K+ E+L +V+E+ + +S ++ + EL L
Sbjct: 577 VTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEK 636
Query: 475 -----LRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE-----VTRTDHQREI 524
++++ EL E+ K A D+ L ++LQ+K + T+ D
Sbjct: 637 VSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAK 696
Query: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETA 584
K+ ++ E+H KE K Y + E+ ++E E KLE + E
Sbjct: 697 LQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVK------------- 743
Query: 585 IASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK 644
AS +QA+++L+ + +L T +E + ++E + S R K
Sbjct: 744 -ASKEQALQDLQ------------QQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQK 790
Query: 645 EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQ-----------EAE 693
+ EAL + K+ K++E + ++ + + ++ E+ N++Q E E
Sbjct: 791 KSEALESIKQKLTKQEEEK-QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKE 849
Query: 694 IKVKELEVLQAKCNEQTKVIDNFTSQLKATEEK----LLDLDA--------LRKASSEGK 741
+ EL ++ K ++ + + N S+ + +K +LDL+ L+
Sbjct: 850 ALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTL 909
Query: 742 SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE 801
E K+L++ LE ++ L++E N+ + L+ E + LQ N++E+ Q E
Sbjct: 910 KEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969
Query: 802 TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK----EEQFNMLSSDLEKLRENLA 857
+K+++ L+ + A + ++ +Q+ + + Q+ +E+ ++L ++ EK +E
Sbjct: 970 QKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFK 1029
Query: 858 DMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
+++ F RE +L+ ++ L++ ++ D S ++ ++ +L + +L
Sbjct: 1030 QLQSDFYG---RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQ------EL 1080
Query: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
K KA ++E + K EQ QE K ++ +KE K +L + ++ + +
Sbjct: 1081 KTAKA---------TLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNE-KSKLAEIE 1130
Query: 978 ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAK 1037
E+K R E+ ++ + L+ L++ ++ ++ L+Q+ EL+ +AD K
Sbjct: 1131 EIKCRQEKEITKLN-------EELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLK 1183
Query: 1038 AAQTAEDA-MQIMEQMTKEKTETL-------------------ASLEDTKQTNAKLQNEL 1077
AA E QI++ K++ E L ++ ++ AKL ++
Sbjct: 1184 AAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQI 1243
Query: 1078 DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLA 1137
L EN +E S+ ++ ++ ++ R EI L+ + AL E +K
Sbjct: 1244 TALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGE 1303
Query: 1138 EELGRSRDEVTSHQ-KLEEERSVL-----NNQLLEMKKRESKFIKDADEEK 1182
E+ + + +V Q KL+ + + NQ L++K ++ K A++ +
Sbjct: 1304 GEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNE 1354
Score = 105 bits (262), Expect = 3e-22
Identities = 161/724 (22%), Positives = 313/724 (43%), Gaps = 168/724 (23%)
Query: 729 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT---RELQGRELK 785
D+ LR+ + ++ +K+ + E +K+++ + + E+ +T ELQ E +
Sbjct: 84 DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQ 143
Query: 786 LTNLQENLSEVSQVKETLEK-------ELQILKEKF------AEASEEAVS--------- 823
L Q + Q+K+ E+ E+ +K K+ EA+E+ V+
Sbjct: 144 LEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 824 -----------VQRSMQETVNKLHQKEEQFNMLSSDL--------EKLRENLADMEAKFR 864
+QR E V L ++ Q L ++ EKL++ +++++
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 865 EKD----EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN----DELRLKERDVEELQ 916
+ + +L K +++ + E+ K+ + ++LT+ N + L KE+D +L+
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLK-SSVNELTQKNQTLTENLLKKEQDYTKLE 322
Query: 917 LK-----LTKANENASFLQKSIEDMTVKAEQSQQEAA--KKHEE--EKKELERKLSDLEK 967
K ++K N A+ QK ++ +++ S E + + H E EK E +KL +
Sbjct: 323 EKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELS 382
Query: 968 KMETSHNQCQELKARYERATSETKTKHEEILQ------NLQKTLLDTEDKLKGAREENSG 1021
++ET + Q LKA +++ + + K + LQ L LL+TE +L E G
Sbjct: 383 EVETKY---QHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL----GEAHG 435
Query: 1022 LLQELEELRKQADKAKAAQTAEDAMQI--MEQMTKEK----TETLASLEDTKQ------- 1068
L+E +L + K Q A+ +++ +E+ KEK TE L+ TKQ
Sbjct: 436 RLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQA 495
Query: 1069 ----TNAKL---QNELDTL------KENNLKNVEE-LNKSKELLTVENQKMEEFRKEIE- 1113
T AKL QN+L+ + K+ ++N+E L KSKE +++ ++ E+ +I+
Sbjct: 496 LQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQA 555
Query: 1114 ----------------TLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEER 1157
TL++ Q +++L E + + E L E +H + ++R
Sbjct: 556 GEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDR 615
Query: 1158 --------SVLNNQLLEMKKRESKF---IKDADE-----------EKASLQKSISITSAL 1195
+ LN+QL E K++ S+ IK E ++A LQ +
Sbjct: 616 VLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNA 675
Query: 1196 LTEKDAELEKLRNEV----TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK-- 1249
L +K EL K+ ++ L+ + L S ++ + + LE K + LE Q+K
Sbjct: 676 LQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKL 735
Query: 1250 ------------------ENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKN 1291
+ +RQL++ + + +A E + E + + ++S +DLQ+K+
Sbjct: 736 EADSLEVKASKEQALQDLQQQRQLNT---DLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 1292 QDLK 1295
+ L+
Sbjct: 793 EALE 796
Score = 95.5 bits (236), Expect = 3e-19
Identities = 135/633 (21%), Positives = 281/633 (44%), Gaps = 81/633 (12%)
Query: 346 KISGTTALQEALKEKQQHIE----------QLLAERDL---ERAEVAKATSHVGEIEQEL 392
K S ALQ+ +++Q + + QL E+++ R ++ K + + I+Q+L
Sbjct: 743 KASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKL 802
Query: 393 A---------------LARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRK 437
L+++ QH EL ++ T ++ EK L+ +L K K
Sbjct: 803 TKQEEEKQILKQDFETLSQETKIQHE-ELNNRIQTTVTELQKVKMEKEALMTELSTVKDK 861
Query: 438 VEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLA-----LRVQ------EVAELRRR 486
+ + ++ +K + E K+ I++LEK L+VQ E EL++
Sbjct: 862 LSKVSDSLKN---SKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKS 918
Query: 487 LESNKPAGDVDMSLSLLQEISSLQEKL---EVTRTDHQREITSLKEHFGAREETHQ---K 540
LE K A S L E++S+QE+L + T +++E L+ + +++ + K
Sbjct: 919 LEKEKEA-----SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFS 600
+I+AL + + L++KL+ + + +A K K+ +++++ E K S
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 601 KGLGTETAEFA---ELKTQIEKMRLDYQHEIENL-----QNQQDSERAAHAKEMEALRAK 652
G E+ A +LK+ EK+ L + I N QN+ E +E AK
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAK 1093
Query: 653 LMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KEL----EVLQAKCN 707
+ ++E+ +L+ I+ K +++ LV + L +++E + + KE+ E L++
Sbjct: 1094 KEQQLQERCKALQDIQ-KEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKL 1152
Query: 708 EQTKVIDNFTSQLKATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
E K I N + ++ L+L D+L+ A + K + L+ Q++ E+++K I
Sbjct: 1153 ESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFI 1212
Query: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
EK A+ + E++ +E+ + +EN ++++ L + L +K+++ +
Sbjct: 1213 EKEAK------LHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSE 1266
Query: 824 VQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
+++ + ++ E + L E E E ++ + ++++ + KL+N
Sbjct: 1267 LEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEG---EIEKLQTKVLELQRKLDNT 1323
Query: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916
A + ++ +N S K L K + E+Q
Sbjct: 1324 TAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 86.3 bits (212), Expect = 2e-16
Identities = 122/513 (23%), Positives = 221/513 (43%), Gaps = 54/513 (10%)
Query: 836 HQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSG--- 892
H E + D+ LR+ + D++A +E+ E+L K EK + + K G
Sbjct: 72 HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVT 131
Query: 893 DNSSQLTKMNDELRLKERDVEELQLKLTK--ANENASFLQKSIEDMTVK--AEQSQQEAA 948
D+S++L + E +L+E E +K K + A+ L I D+ K E+S +EAA
Sbjct: 132 DSSAELQSL--EQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
Query: 949 KKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDT 1008
E+K++ L +++ Q+LK T + E + L+K L+
Sbjct: 190 ----------EQKVTRLTEELNKEATVIQDLK------TELLQRPGIEDVAVLKKELVQV 233
Query: 1009 EDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA--MQIMEQMTKEKTET---LASL 1063
+ + E +E E+L+ + K ++ + +A Q+ ++ K E + L
Sbjct: 234 QTLMDNMTLERE---RESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQEL 290
Query: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1123
+ K + +L + TL EN LK ++ K +E E+ + + + Q
Sbjct: 291 QKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQ 350
Query: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK- 1182
+LSA + ++ EL + E T QKL+EE S + + + K E K ++ EEK
Sbjct: 351 SRLSASETSLHRIHVELS-EKGEAT--QKLKEELSEVETKYQHL-KAEFKQLQQQREEKE 406
Query: 1183 ---ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLEL 1239
LQ I+ + L E + +L + + R + +S K + E L+L
Sbjct: 407 QHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR-QLSSEKLMDK-----EQQVADLQL 460
Query: 1240 KVKNLELQLKE---NKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQ---RKNQD 1293
K+ LE QLKE N +L T Q E + Q+S L DL+ R+ D
Sbjct: 461 KLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD 520
Query: 1294 LKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSK 1326
K++ + EA L + ++++ + + ++ +K
Sbjct: 521 KDQKIQNL-EALLQKSKENISLLEKEREDLYAK 552
>gi|18496983 CAP-GLY domain containing linker protein 3 [Homo
sapiens]
Length = 547
Score = 173 bits (439), Expect = 9e-43
Identities = 100/256 (39%), Positives = 142/256 (55%), Gaps = 42/256 (16%)
Query: 59 RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118
R+G+RV ++G K G ++F G T+FA GQW G+ LDEP GKNDGSV GVRYF C P +G+F
Sbjct: 295 RLGDRVLLDGQKTGTLRFCGTTEFASGQWVGVELDEPEGKNDGSVGGVRYFICPPKQGLF 354
Query: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPSTP----SNIPQKPSQP 174
SK+++ V A S V+S+P TP S + K +
Sbjct: 355 ASVSKISKAVDA----------------------PPSSVTSTPRTPRMDFSRVTGK-GRR 391
Query: 175 AAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGET 234
K TP +S S+ +L + K ++GD+VLV G K G+VRF G+T
Sbjct: 392 EHKGKKKTP--------SSPSLGSLQQRDGAK-----AEVGDQVLVAGQKQGIVRFYGKT 438
Query: 235 DFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN 294
DFA G W G+ELD+P GK+DG+V G RYF C P++G+FAP ++ +IG +T + +
Sbjct: 439 DFAPGYWYGIELDQPTGKHDGSVFGVRYFTCPPRHGVFAPASRIQRIG--GSTDSPGDSV 496
Query: 295 AVRRVMATTSASLKRS 310
++V T KR+
Sbjct: 497 GAKKVHQVTMTQPKRT 512
Score = 100 bits (248), Expect = 1e-20
Identities = 59/146 (40%), Positives = 80/146 (54%), Gaps = 9/146 (6%)
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
A P L K + N+ G++ L++GDRVL+ G K G +RF G T+FA G+
Sbjct: 265 AVPLSCALPKVTLPNYDNVP--GNLMLSALGLRLGDRVLLDGQKTGTLRFCGTTEFASGQ 322
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI--GFPSTTPAKAKANAVRR 298
W GVELDEP GKNDG+V G RYF C PK GLFA V K++K PS+ + + +
Sbjct: 323 WVGVELDEPEGKNDGSVGGVRYFICPPKQGLFASVSKISKAVDAPPSSVTSTPRTPRMDF 382
Query: 299 VMATTSA-----SLKRSPSASSLSSM 319
T K++PS+ SL S+
Sbjct: 383 SRVTGKGRREHKGKKKTPSSPSLGSL 408
>gi|31982881 CAP-GLY domain containing linker protein family, member
4 [Homo sapiens]
Length = 705
Score = 173 bits (438), Expect = 1e-42
Identities = 117/337 (34%), Positives = 174/337 (51%), Gaps = 63/337 (18%)
Query: 59 RVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGSVAGVRYFQCEPLKGIF 118
++G+RV + G K G ++F G T+FA GQWAGI LDEP GKN+GSV V+YF+C P GIF
Sbjct: 284 KLGDRVVIAGQKVGTLRFCGTTEFASGQWAGIELDEPEGKNNGSVGKVQYFKCAPKYGIF 343
Query: 119 TRPSKLTRKVQAEDEANGLQTTPASRATSPLCTS-----------------TASMVSSSP 161
SK+++ A+ + TP+++A PL S T+ S+S
Sbjct: 344 APLSKISK---AKGRRKNITHTPSTKAAVPLIRSQKIDVAHVTSKVNTGLMTSKKDSASE 400
Query: 162 STPSNIPQKPSQPAAKE-----------------------PSATPPISNLTKTASES--I 196
ST S P + + ++ P IS+ KT S+S +
Sbjct: 401 STLSLPPGEELKTVTEKDVALLGSVSSCSSTSSLEHRQSYPKKQNAISSNKKTMSKSPSL 460
Query: 197 SNLSEAG---------SIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGEWCGVELD 247
S+ + AG + + E EL++G+RVLV G + G +RF G T+FA G W G+EL+
Sbjct: 461 SSRASAGLNSSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELE 520
Query: 248 EPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKAN-------AVRRVM 300
+P GKNDG+V G +YF C P+YG+FAP +V ++ T ++ +N RR
Sbjct: 521 KPHGKNDGSVGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSF 580
Query: 301 ATTSASLKRSPSASSLSSMSSVA--SSVSSRPSRTGL 335
+TTSAS ++ + + S S A S SS P+ G+
Sbjct: 581 STTSASSQKEINRRNAFSKSKAALRRSWSSTPTAGGI 617
Score = 143 bits (360), Expect = 1e-33
Identities = 88/241 (36%), Positives = 122/241 (50%), Gaps = 17/241 (7%)
Query: 43 SSTPSSETQEEFVDDFRVGERVWVNGNKPGFIQFLGETQFAPGQWAGIVLDEPIGKNDGS 102
SS S+ + R+GERV V G + G I+F G T FAPG W GI L++P GKNDGS
Sbjct: 470 SSATSTANNSRCEGELRLGERVLVVGQRLGTIRFFGTTNFAPGYWYGIELEKPHGKNDGS 529
Query: 103 VAGVRYFQCEPLKGIFTRPSKLTRKVQAEDEANGLQTTPASRATSPLCTSTASMVSSSPS 162
V GV+YF C P GIF PS++ R + D + + + + + S ++ +SS
Sbjct: 530 VGGVQYFSCSPRYGIFAPPSRVQRVTDSLDTLSEISSNKQNHSYPGFRRSFSTTSASS-- 587
Query: 163 TPSNIPQKPSQPAAKEPSATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLV-G 221
KE + S S S+ AG I +G +L G +VL+
Sbjct: 588 -------------QKEINRRNAFSKSKAALRRSWSSTPTAGGI-EGSVKLHEGSQVLLTS 633
Query: 222 GTKAGVVRFLGETDFAKGEWCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI 281
+ G VR++G TDFA G W G+EL GKNDG+V RYF C+P +G+ +VT
Sbjct: 634 SNEMGTVRYVGPTDFASGIWLGLELRSAKGKNDGSVGDKRYFTCKPNHGVLVRPSRVTYR 693
Query: 282 G 282
G
Sbjct: 694 G 694
Score = 101 bits (252), Expect = 4e-21
Identities = 58/169 (34%), Positives = 84/169 (49%), Gaps = 7/169 (4%)
Query: 181 ATPPISNLTKTASESISNLSEAGSIKKGERELKIGDRVLVGGTKAGVVRFLGETDFAKGE 240
A P N++K + +++ G LK+GDRV++ G K G +RF G T+FA G+
Sbjct: 254 AVPLSCNISKAMLPNYDHVT--GKAMLTSLGLKLGDRVVIAGQKVGTLRFCGTTEFASGQ 311
Query: 241 WCGVELDEPLGKNDGAVAGTRYFQCQPKYGLFAPVHKVTKI-----GFPSTTPAKAKANA 295
W G+ELDEP GKN+G+V +YF+C PKYG+FAP+ K++K T KA
Sbjct: 312 WAGIELDEPEGKNNGSVGKVQYFKCAPKYGIFAPLSKISKAKGRRKNITHTPSTKAAVPL 371
Query: 296 VRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYA 344
+R + + + S S + S S P L T T A
Sbjct: 372 IRSQKIDVAHVTSKVNTGLMTSKKDSASESTLSLPPGEELKTVTEKDVA 420
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 173 bits (438), Expect = 1e-42
Identities = 224/1032 (21%), Positives = 464/1032 (44%), Gaps = 141/1032 (13%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LK+ L+ ++ V + ++ LTE + I+
Sbjct: 938 AELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDETIAKL 996
Query: 351 TALQEALKEK-QQHIEQLLAERDLERAEVAKATSHV--------GEIEQELALARD-GHD 400
T ++AL+E QQ ++ L E D + KA + + G +EQE L D
Sbjct: 997 TKEKKALQEAHQQTLDDLQMEEDKVNT-LTKAKTKLEQQVDDLEGSLEQEKKLCMDLERA 1055
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATV 460
+ LE + K+ Q TM + +K +L +L++++ ++ +LQ ++E+E L+
Sbjct: 1056 KRKLEGDLKLAQESTM--DTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIK 1113
Query: 461 SEKSRIMELEKDLALR--------------VQEVAELRRRLE--SNKPAGDVDMSLSLLQ 504
++RI ELE+++ +E+ E+ RLE + ++M+
Sbjct: 1114 ELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA 1173
Query: 505 EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK---- 560
E ++ LE + H+ +L++ ++I +L +KL KE LK
Sbjct: 1174 EFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233
Query: 561 ---SKLEHANKENSDVIALWK------SKLETAIASHQQAMEELKVSFSKGLGTETAEFA 611
S +E +K ++ + + S+++T Q+ + EL ++ L TE+ EF+
Sbjct: 1234 DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR-LHTESGEFS 1292
Query: 612 -------------------------ELKTQIE---KMRLDYQHEIENLQNQQDSERAAHA 643
ELK Q+E K + H +++ ++ D R +
Sbjct: 1293 RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL-QEAEIKVKELEVL 702
+E EA +A+L + + + + + R+K + Q E+E+ KL Q + + +E +
Sbjct: 1353 EEQEA-KAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAV 1411
Query: 703 QAKCN--EQTK-----VIDNFTSQLKATEEKLLDLDALR----KASSEGKSEMKKLRQQL 751
+KC E+TK +++ ++ + + LD + K +E K + ++ + +L
Sbjct: 1412 NSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAEL 1471
Query: 752 EAAEKQIKHLEIE----KNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL 807
EA++K+ + L E KNA + E RE K NLQ+ +S++++ K +
Sbjct: 1472 EASQKESRSLSTELFKVKNAYEESLDHL--ETLKRENK--NLQQEISDLTEQIAEGGKHI 1527
Query: 808 QILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKD 867
L++ + E +Q S++E L +E + + +L +++ ++++ K EKD
Sbjct: 1528 HELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVK---SEIDRKIAEKD 1584
Query: 868 EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANE 924
E +QL + N + + M +++ ND LR+K E D+ E++++L AN
Sbjct: 1585 EELDQLKR------NHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANR 1638
Query: 925 NASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKAR 982
A+ +++ + +K Q + A + +++ KE +L+ +E++ + +EL+A
Sbjct: 1639 QAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE---QLAMVERRANLMQAEVEELRAS 1695
Query: 983 YERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQEL-EELRKQ 1032
ER K +E+L ++ +L++T+ KL+ + G ++++ +E R
Sbjct: 1696 LERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNA 1755
Query: 1033 ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELN 1092
+KAK A T DA + E++ KE+ +T A LE K +N T+K+ L+ L+
Sbjct: 1756 EEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMK------KNMEQTVKDLQLR----LD 1802
Query: 1093 KSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV--TSH 1150
++++L ++ +K+I+ L+ + ++ + Q+ NV+ + L + V ++
Sbjct: 1803 EAEQL------ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTY 1856
Query: 1151 QKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
Q E+ +++L Q L K + E+A Q ++++ + + E K R ++
Sbjct: 1857 QTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAKERADI 1916
Query: 1211 TVLRGENASAKS 1222
+ KS
Sbjct: 1917 AESQVNKLRVKS 1928
Score = 155 bits (392), Expect = 3e-37
Identities = 212/1044 (20%), Positives = 452/1044 (43%), Gaps = 144/1044 (13%)
Query: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
+KE+ + ++ LA+ + +R E+ + + + + +L L + + E + DQL
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQL--- 912
Query: 417 VEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALR 476
+ K++L +++E + ED + E + K LE K I +LE LA
Sbjct: 913 ----IKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA-- 966
Query: 477 VQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREE 536
E + NK + L + I+ L ++ + + HQ+ + L +
Sbjct: 967 ---KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDL--------Q 1015
Query: 537 THQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK 596
+ ++ L A KL ++ + L+ LE K D + K KLE +LK
Sbjct: 1016 MEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD-LERAKRKLE----------GDLK 1064
Query: 597 VSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKV 656
++ + TE K Q+ + + E+ NLQ + + E+A A +++ +L
Sbjct: 1065 LAQESTMDTEND-----KQQLNEKLKKKEFEMSNLQGKIEDEQAL-AIQLQKKIKELQAR 1118
Query: 657 IKEKENSLEAIRSKLDKAEDQH---LVEMEDTLNKLQEA----EIKVKELEVLQAKCNEQ 709
I+E E +EA R+ KAE Q E+E+ +L+EA +++ + +A+ +
Sbjct: 1119 IEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKM 1178
Query: 710 TKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEM----KKLRQQLEAAEKQIKHLEIEK 765
+ ++ T Q +AT ALRK ++ +E+ L++ + EK+ L++E
Sbjct: 1179 RRDLEESTLQHEATAA------ALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEI 1232
Query: 766 NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQ 825
N +S ++++ E L++ LSE+ +E ++ + L + A E+
Sbjct: 1233 NDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFS 1292
Query: 826 RSMQE---TVNKLHQKEEQF------------------NMLSSDLEKLRENLADMEAKFR 864
R + E V++L + ++ F + L+ L+ R + + ++
Sbjct: 1293 RQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYE 1352
Query: 865 EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ERDVEELQ 916
E+ E + +L + K +++A+ ++ Q T+ +E + K E VE +
Sbjct: 1353 EEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVN 1412
Query: 917 LKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC 976
K + LQ +ED+ + E+S A +++++ ++ L++ ++K E
Sbjct: 1413 SKCASLEKTKQRLQNEVEDLMIDVERS-NAACIALDKKQRNFDKVLAEWKQKYE------ 1465
Query: 977 QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1036
E +A E + E+++ E+ + ++ ++ D L+ + EN L QE+ +L +Q A
Sbjct: 1466 -ETQAELEASQKESRSLSTELFK-VKNAYEESLDHLETLKRENKNLQQEISDLTEQI--A 1521
Query: 1037 KAAQTAEDAMQIMEQMTKEKTETLASLEDTK-------------------------QTNA 1071
+ + + ++ +Q+ EK+E SLE+ + + A
Sbjct: 1522 EGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIA 1581
Query: 1072 KLQNELDTLKENNLKNVE--------ELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQK 1122
+ ELD LK N+L+ VE E+ + L ++ +KME E+E L A Q
Sbjct: 1582 EKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIK-KKMEGDLNEMEIQLNHANRQA 1640
Query: 1123 SQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK 1182
++ L L+ L + D + L+E QL +++R + + +E +
Sbjct: 1641 AEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE-------QLAMVERRANLMQAEVEELR 1693
Query: 1183 ASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVK 1242
ASL++ T + EL V +L +N SL + + LE+D +++ +++
Sbjct: 1694 ASLER----TERGRKMAEQELLDASERVQLLHTQNT---SLINTKKKLETDISQIQGEME 1746
Query: 1243 NLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMS 1302
++ + + + + + + A+E ++ Q++ L + ++++ +DL+++++
Sbjct: 1747 DIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTVKDLQLRLDEAE 1805
Query: 1303 EAALNGNGDDLNNYDSDDQEKQSK 1326
+ AL G + ++ +E +S+
Sbjct: 1806 QLALKGGKKQIQKLEARVRELESE 1829
Score = 114 bits (285), Expect = 7e-25
Identities = 123/540 (22%), Positives = 236/540 (43%), Gaps = 48/540 (8%)
Query: 783 ELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
E ++ N++E + + E + + L+EK +E +Q +Q + L EE+
Sbjct: 850 EKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERC 909
Query: 843 NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMN 902
+ L +L + ++ + +++E +L K KLE++ +E+ K D L K+
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 903 DELRLKERDVEELQLKLTKANENASFLQK------SIEDMTVKAEQSQQEAAKKHEEEKK 956
E E V+ L ++ +E + L K T+ Q +++ + K
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKT 1029
Query: 957 ELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTE------- 1009
+LE+++ DLE +E C +L ERA K K E L+ Q++ +DTE
Sbjct: 1030 KLEQQVDDLEGSLEQEKKLCMDL----ERA----KRKLEGDLKLAQESTMDTENDKQQLN 1081
Query: 1010 DKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQT 1069
+KLK E S L ++E+ +QA + + ++ +E++ +E AS ++
Sbjct: 1082 EKLKKKEFEMSNLQGKIED--EQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQ 1139
Query: 1070 NAKLQNELDTLKENNLKNVEELNKSKELLTVENQKME-EFRKEIETLKQAAAQKSQQLSA 1128
+ L EL+ + E +EE + N+K E EF+K L+++ Q +A
Sbjct: 1140 RSDLSRELEEISE----RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195
Query: 1129 LQEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK 1187
L++++ ELG D + QKLE+E+S L ++ ++ ++ + KA+ +K
Sbjct: 1196 LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN----METVSKAKANFEK 1251
Query: 1188 SISITSALLTE---KDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKN- 1243
L+E K+ E ++L NE+ +A LH+ ES + +L K+
Sbjct: 1252 MCRTLEDQLSEIKTKEEEQQRLINEL------SAQKARLHT-----ESGEFSRQLDEKDA 1300
Query: 1244 LELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ QL K+ + Q +E+ +A+ + L S D + + + E +E
Sbjct: 1301 MVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAE 1360
Score = 91.3 bits (225), Expect = 6e-18
Identities = 148/684 (21%), Positives = 294/684 (42%), Gaps = 77/684 (11%)
Query: 290 KAKANAVRRVMATTSASLKRSPSASS-----LSSMSSVASSVS-SRPSRTGLLTETSSRY 343
K K +R++ SA R + S L ++ S +S + + T + E +
Sbjct: 1264 KTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQL 1323
Query: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD--- 400
+ + L AL+ + + L + + E+ A+ + + E+A R ++
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDA 1383
Query: 401 -QHVLELEAKMDQLRTMVEAADREKVELLNQ----LEEEKRKVEDLQFRVEEESITKGDL 455
Q ELE +L ++ A+ E VE +N LE+ K++ LQ VE+ I
Sbjct: 1384 IQRTEELEEAKKKLAQRLQDAE-EHVEAVNSKCASLEKTKQR---LQNEVEDLMIDVERS 1439
Query: 456 EVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEV 515
A ++ + +K LA Q+ E + LE+++ +S L + ++ +E L+
Sbjct: 1440 NAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESR-SLSTELFKVKNAYEESLDH 1498
Query: 516 TRT------DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK- 568
T + Q+EI+ L E K I L ++L E L++ LE A
Sbjct: 1499 LETLKRENKNLQQEISDLTEQIAEGG----KHIHELEKVKKQLDHEKSELQTSLEEAEAS 1554
Query: 569 ---ENSDVIALW------KSKLETAIASHQQAMEELKVSFSKGLGTETAEF-AELKTQIE 618
E ++ + KS+++ IA + +++LK + + + + + AE++++ +
Sbjct: 1555 LEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRND 1614
Query: 619 KMRLDYQHEIENLQNQQDSERAAHAKEMEALR--AKLMKVIKEKENSLE-AIRSKLDKAE 675
+R+ + E +L + A+ + EALR ++K+ + L+ AIR + D E
Sbjct: 1615 ALRIKKKME-GDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE 1673
Query: 676 DQHLVEMEDTLNKLQEAEI-----------KVKELEVLQAKCNEQTKVIDNFTSQLKATE 724
+VE L + + E+ K+ E E+L A +E+ +++ + L T+
Sbjct: 1674 QLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDA--SERVQLLHTQNTSLINTK 1731
Query: 725 EKL-LDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRE 783
+KL D+ ++ + E + ++ + A + E E ++ + R + E
Sbjct: 1732 KKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNME 1791
Query: 784 LKLTNLQENLSEVSQVK-ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQF 842
+ +LQ L E Q+ + +K++Q L+ + E E S Q+ E V L + E +
Sbjct: 1792 QTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRV 1851
Query: 843 NMLSSDLEKLRENLADME-----------AKFREKDEREEQL---IKAKEKLENDIAEIM 888
L+ E+ R+N+ ++ A R+ +E EEQ + KL++++ E
Sbjct: 1852 KELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEEAK 1911
Query: 889 KMSGDNSSQLTKMNDELRLKERDV 912
+ + SQ+ K LR+K R+V
Sbjct: 1912 ERADIAESQVNK----LRVKSREV 1931
Score = 79.7 bits (195), Expect = 2e-14
Identities = 112/455 (24%), Positives = 203/455 (44%), Gaps = 85/455 (18%)
Query: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 988
L KS E T K + +E +K +EE + E K +LE+KM T + +L+ + + A +
Sbjct: 843 LLKSAE--TEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ-AEA 899
Query: 989 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQI 1048
+ EE L KT + E K+K E+ E + ++ A TA+
Sbjct: 900 DALADAEERCDQLIKTKIQLEAKIK-----------EVTERAEDEEEINAELTAK----- 943
Query: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEE-----------LNKSKEL 1097
++ E +E ++D + T AK++ E EN +KN+ E L K K+
Sbjct: 944 KRKLEDECSELKKDIDDLELTLAKVEKEKHA-TENKVKNLTEEMAGLDETIAKLTKEKKA 1002
Query: 1098 L------TVENQKMEEFRKEIETLKQAAAQKSQQLSALQ---EENVKLAEELGRSRDEVT 1148
L T+++ +MEE ++ TL +A + QQ+ L+ E+ KL +L R++ ++
Sbjct: 1003 LQEAHQQTLDDLQMEE--DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLE 1060
Query: 1149 SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL-------LTEKDA 1201
KL +E S ++ + K++ ++ +K + E ++LQ I AL + E A
Sbjct: 1061 GDLKLAQE-STMDTE--NDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQA 1117
Query: 1202 ELEKLRNEVTVLRGENASA--------KSLHSVVQTLE----SDKVKLELKVKNLELQLK 1249
+E+L E+ R A A + L + + LE + ++E+ K E + +
Sbjct: 1118 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN-KKREAEFQ 1176
Query: 1250 ENKRQLSSSSGNTDTQA------DEDERAQ-ESQIDFLNSVIVDLQRKNQDLKMKV---- 1298
+ +R L S+ + A D A+ QID L V L+++ +LKM++
Sbjct: 1177 KMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLA 1236
Query: 1299 ---EMMSEAALNGN------GDDLNNYDSDDQEKQ 1324
E +S+A N D L+ + ++E+Q
Sbjct: 1237 SNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQ 1271
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 172 bits (437), Expect = 2e-42
Identities = 235/1057 (22%), Positives = 471/1057 (44%), Gaps = 117/1057 (11%)
Query: 315 SLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLE 374
S+S+ + + SV S S +++ S + +I+ + LKE+ +E E
Sbjct: 1804 SMSTRPTCSESVPSAKSANPAVSKDFSSHD-EINNYLQQIDQLKERIAGLE--------E 1854
Query: 375 RAEVAKATSHVGEIEQELALA----RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQ 430
+ K S E E+ L+ +DG + + E KM+ L ++ +L
Sbjct: 1855 EKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKET 1914
Query: 431 LEEEKRKVED-LQFRVEEESITKGDL--EVATVSEKSRIMELE-KDLALRVQEVAELRRR 486
EEEK +E+ L ++ E + + G+ +V K+ ++E E K+L V E+ E +++
Sbjct: 1915 AEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQ 1974
Query: 487 LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALY 546
L K + ++ L++I Q+ E H +E+ L + Q+E+K L
Sbjct: 1975 LVKEKTKVESEIRKEYLEKIQGAQK--EPGNKSHAKELQELLKE-------KQQEVKQLQ 2025
Query: 547 TAT----EKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKG 602
EK+S ++K+ LE E+ + + K L A+ ++A EL SF
Sbjct: 2026 KDCIRYQEKISALERTVKA-LEFVQTESQKDLEITKENLAQAVEHRKKAQAEL-ASFKVL 2083
Query: 603 LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKEN 662
L +E A + K++ + Q E++++Q + + +E K +K K +
Sbjct: 2084 LDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQE 2143
Query: 663 SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKA 722
L+A+R + E+ + E++ TLNK K KE++ LQ + + FT + +
Sbjct: 2144 KLDALRREKVHLEET-IGEIQVTLNK------KDKEVQQLQENLDSTVTQLAAFTKSMSS 2196
Query: 723 TEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
++ D D + E K +K +++ E++I+ E S + +L+
Sbjct: 2197 LQD---DRD---RVIDEAKKWERKFSDAIQSKEEEIRLKE-------DNCSVLKDQLRQM 2243
Query: 783 ELKLTNLQENLSEVSQVKETLEKELQI---LKEKFAEASE-EAVSVQRSMQETVNKLHQK 838
+ + L+ N+S + K+ E + Q L++K + + E + ++ET + H
Sbjct: 2244 SIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSS 2303
Query: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIA------EIMKMSG 892
+ + L S+L+ L++ L D+ + E++ L + E DI E ++
Sbjct: 2304 QNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDL 2363
Query: 893 DNSSQLT-KMNDELRLKERDV--------EELQLKLTKANENASFLQKSIEDMTVKAEQS 943
S +LT ++++E+ +KE+ + E +Q+ + + + K I+++ Q
Sbjct: 2364 QASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHD---KEIKELENLLSQE 2420
Query: 944 QQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE---RATSETKTKHEEILQN 1000
++E EE KK ++ K + L + ++T + + KA+ + ++ S + + I+ +
Sbjct: 2421 EEENIVLEEENKKAVD-KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGD 2479
Query: 1001 LQKT-------LLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIM---- 1049
Q+ +L+ + ++ A EN+ L +E+ LR D + DA I
Sbjct: 2480 YQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYRED 2539
Query: 1050 --EQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKS-KELLTVENQKME 1106
+ +T + ++ LE Q N +L+N+ L+E LK EE N+ + ++ +
Sbjct: 2540 LNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEK-LKESEEANEDLRRSFNALQEEKQ 2598
Query: 1107 EFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLE 1166
+ KEIE+LK + +Q ++Q++ALQEE LG ++ K++EE ++L
Sbjct: 2599 DLSKEIESLKVSISQLTRQVTALQEEGT-----LGLYHAQL----KVKEEEV---HRLSA 2646
Query: 1167 MKKRESKFIKDADEEKASLQKSISITSALLTEK-DAELEKLRNEVTVLRGENASAKSLHS 1225
+ K I + +EE +QK + + +K EL+ L ++ ++R E +A+
Sbjct: 2647 LFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEER-- 2704
Query: 1226 VVQTLESDKVKLELKV-------KNLELQLKENKRQLSSSSGNTDTQADEDERAQESQID 1278
V L D V++E K+ K L Q++ R +SS + D A+E+ + + D
Sbjct: 2705 -VAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRD-HANEELDELKRKYD 2762
Query: 1279 FLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNN 1315
+ L+ + + + ++SE A + N + N+
Sbjct: 2763 ASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENS 2799
Score = 154 bits (388), Expect = 7e-37
Identities = 226/1006 (22%), Positives = 436/1006 (43%), Gaps = 133/1006 (13%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
+++ K KQQ I +L E D RAEV A E + L + + + ++ + +
Sbjct: 1678 MRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYET 1737
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVE-DLQFRVEEESITKGDLEVATVSEKSRIM--EL 469
L ++ EK L ++++ K ++E ++ + E+ K D + E ++ + E
Sbjct: 1738 LSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGET 1797
Query: 470 EKDLALRVQ---EVAELRRRLESNKPAGDVDMSL-----SLLQEISSLQEKLEVTRTDHQ 521
E+ +L + +E +S PA D S + LQ+I L+E++ + Q
Sbjct: 1798 EEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ 1857
Query: 522 RE------ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL-------EHANK 568
+ + + K ++ T E+K L K++ N+ ++ +L E A +
Sbjct: 1858 KNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEE 1917
Query: 569 ENSDV---IALWKSKLETAIASH------QQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
E D+ + ++L +I ++ Q EL S K L +E E K Q+ K
Sbjct: 1918 EKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVK 1977
Query: 620 MRLDYQHEI-----ENLQN-QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDK 673
+ + EI E +Q Q++ +HAKE++ L +KEK+ ++ ++ +
Sbjct: 1978 EKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQEL-------LKEKQQEVKQLQKDCIR 2030
Query: 674 AEDQHLVEMEDTLNKLQEAEIK-VKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732
+++ + +E T+ L+ + + K+LE+ K N V +Q + K+L LD
Sbjct: 2031 YQEK-ISALERTVKALEFVQTESQKDLEI--TKENLAQAVEHRKKAQAELASFKVL-LDD 2086
Query: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQEN 792
+ ++ ++ KL+++L++ ++ +K +K+ + + E +E K N+QE
Sbjct: 2087 TQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKK--NMQEK 2144
Query: 793 LSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKL 852
L + + K LE+ + ++ + +E +Q ++ TV +L + + L D +++
Sbjct: 2145 LDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRV 2204
Query: 853 RENLADMEAKFREKDEREEQLIKAKE---------------KLENDIAEIMKMSGDNSSQ 897
+ E KF + + +E+ I+ KE +E I ++ D
Sbjct: 2205 IDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIW 2264
Query: 898 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKE 957
+K E++L+++ + LQ EN L + +E+ SQ E AK E E K
Sbjct: 2265 ESKAQTEVQLQQKVCDTLQ------GENKELLSQ-LEETRHLYHSSQNELAKL-ESELKS 2316
Query: 958 LERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE 1017
L+ +L+DL +E +C+E K E + E +QN + + E L+ +RE
Sbjct: 2317 LKDQLTDLSNSLE----KCKEQKGNLEGIIRQ----QEADIQNSKFSYEQLETDLQASRE 2368
Query: 1018 ENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK-LQNE 1076
S L +E+ K+ E+A+Q+ +A L K L+N
Sbjct: 2369 LTSRLHEEIN--MKEQKIISLLSGKEEAIQV----------AIAELRQQHDKEIKELENL 2416
Query: 1077 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136
L +E N+ EE +K+ + NQ ME ++T+K+ Q+ QL + VK
Sbjct: 2417 LSQEEEENIVLEEE---NKKAVDKTNQLME----TLKTIKKENIQQKAQLDSF----VKS 2465
Query: 1137 AEELGRSRDEVT-SHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195
L RD + +Q+LEE L + + + I++A E L++ I +
Sbjct: 2466 MSSLQNDRDRIVGDYQQLEERH-------LSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
Query: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255
+ + ++E KL E+ R + L+ V+ +S + +L LE+QL++NK +L
Sbjct: 2519 MDDLNSENAKLDAELIQYR------EDLNQVITIKDSQQKQL------LEVQLQQNK-EL 2565
Query: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1301
+ + + E E A E N+ LQ + QDL ++E +
Sbjct: 2566 ENKYAKLEEKLKESEEANEDLRRSFNA----LQEEKQDLSKEIESL 2607
Score = 150 bits (380), Expect = 6e-36
Identities = 230/1129 (20%), Positives = 478/1129 (42%), Gaps = 188/1129 (16%)
Query: 336 LTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHV-GEIEQEL-- 392
L + Y + ++ E L+ + +++++ ++E + E+ ++ K + V EI +E
Sbjct: 1933 LNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLE 1992
Query: 393 ----ALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEE 448
A G+ H EL+ + + + V+ ++ + ++ +R V+ L+F V+ E
Sbjct: 1993 KIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEF-VQTE 2051
Query: 449 S-----ITKGDLEVATVSEKSRIMEL----------EKDLALRVQEVAELRRRLESNKPA 493
S ITK +L A K EL + + A + + +L++ L+SNK +
Sbjct: 2052 SQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKES 2111
Query: 494 GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA--REETHQKE-IKALYTATE 550
M Q+ L+ +LE H +E +++E A RE+ H +E I +
Sbjct: 2112 VKSQMK----QKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLN 2167
Query: 551 KLSKENESLKSKLEHANKENS-----------------DVIALWKSKLETAIASHQQA-- 591
K KE + L+ L+ + + D W+ K AI S ++
Sbjct: 2168 KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIR 2227
Query: 592 -------------------MEELKVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIE 629
MEELK++ S+ + ++ +T+++ K+ Q E +
Sbjct: 2228 LKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENK 2287
Query: 630 NLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKL 689
L +Q + R + L AKL +K ++ L + + L+K ++Q +E + +
Sbjct: 2288 ELLSQLEETRHLYHSSQNEL-AKLESELKSLKDQLTDLSNSLEKCKEQK-GNLEGIIRQ- 2344
Query: 690 QEAEIKVKEL--EVLQAKCNEQTKVIDNFTSQLKATEEKLLDL-----DALRKASSEGKS 742
QEA+I+ + E L+ ++ ++ E+K++ L +A++ A +E +
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404
Query: 743 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG--RELKLTNLQENLSEVSQVK 800
+ K ++LE Q + I E+ KA T +L + +K N+Q+ S VK
Sbjct: 2405 QHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
Query: 801 E--TLEKELQILKEKFAEASEEAVSV----QRSMQETVNKLHQKEEQFNMLSSDLEKLRE 854
+L+ + + + + E +S+ + +QE + ++ +E+ L S ++ L
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 855 NLADMEAKFREKDEREEQLIKAKEKLENDIAEI-MKMSGDNSSQLTKMNDELRLKERDVE 913
A ++A+ + E Q+I K+ + + E+ ++ + + ++ K+ ++L+ E E
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANE 2584
Query: 914 ELQLKLTKANENASFLQKSIEDMTVKAEQ------------------------------- 942
+L+ E L K IE + V Q
Sbjct: 2585 DLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRL 2644
Query: 943 ------SQQEAAKKHEE---EKKELERKLSDLEKKMETSHNQCQELKARYERA---TSET 990
SQ+ A+ EE +KE +K+ ++E K++ +ELK + A +ET
Sbjct: 2645 SALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLK------KELKHLHHDAGIMRNET 2698
Query: 991 KTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQTAEDAMQIM 1049
+T E + + L + L++ E KL +EN GL +++ R + + A + + +
Sbjct: 2699 ETAEERVAE-LARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDEL 2757
Query: 1050 EQMTKEKTETLASLED----TKQTNAKLQN---ELDTLKENNLKNVEELNKSKELLTVEN 1102
++ + LA L++ ++ +A L +++ +EN+L ++E+LN+ L ++
Sbjct: 2758 KRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQ---LLSKD 2814
Query: 1103 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNN 1162
+++ ++E S+ +++LQ E L EL + R K EE
Sbjct: 2815 EQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFR-------KSEEG------ 2861
Query: 1163 QLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKS 1222
K+R + + E SL+K++ S+L ++D L++L+N N
Sbjct: 2862 -----KQRSAAQPSTSPAEVQSLKKAM---SSLQNDRDRLLKELKNLQQQYLQINQEITE 2913
Query: 1223 LHSVVQTLE--SDKVKL------ELKVKNLELQLKENKRQLSSSSGNTDTQADEDE---- 1270
LH + L+ DK K EL+ +NL Q + ++ ++ SS + +++
Sbjct: 2914 LHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMA 2973
Query: 1271 -RAQESQIDFLNSVIVDLQ---RKNQDLKMKVEMMSEAALNGNGDDLNN 1315
++ Q+ L ++I +L+ + Q LK++ + + + + D N
Sbjct: 2974 ISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQN 3022
Score = 149 bits (376), Expect = 2e-35
Identities = 218/1102 (19%), Positives = 478/1102 (43%), Gaps = 153/1102 (13%)
Query: 326 VSSRPSRTGLLTETSSRYARKISGTT-ALQEALKEKQQHIEQLLAERDLERAEVAKATSH 384
+ +P G + + RK+ + +EALKE + E+L L R + + T
Sbjct: 1464 MKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEEL----SLARGTIERLTKS 1519
Query: 385 VGEIEQE--------------LALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQ 430
+ ++E + LAL ++ D+ + E++ + + +++ + + K+ L
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579
Query: 431 LEEEKRKVEDLQFRVEEESITKGDLEVATV-SEKSRIMELEKDLAL-----------RVQ 478
E++++ V+++ ES+ + +T EK + ++ E ++ L R+Q
Sbjct: 1580 TEDKEKLVKEI------ESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQ 1633
Query: 479 EVAELRRR-----------LESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSL 527
V E R+ E+NK + + QE+ ++EK+ Q++I L
Sbjct: 1634 HVVEAVRQEKQELYGKLRSTEANKKETEKQLQ-EAEQEMEEMKEKMRKFAKSKQQKILEL 1692
Query: 528 -KEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKL---ET 583
+E+ R E H A E L N S+K +LE E + ++S + ++
Sbjct: 1693 EEENDRLRAEVHPAGDTA-KECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDS 1751
Query: 584 AIASHQQAMEELKVSFSKGLGTETAEFAELKTQI-EKMRLDYQHEIENLQNQQDSERAAH 642
Q +++ + SK E E + +T + E+ E E + S R
Sbjct: 1752 LSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTC 1811
Query: 643 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL-EV 701
++ + + ++ V K+ +S + I + L Q + ++++ + L+E + K KE +
Sbjct: 1812 SESVPSAKSANPAVSKD-FSSHDEINNYL-----QQIDQLKERIAGLEEEKQKNKEFSQT 1865
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
L+ + N I +LK +E++ ++ L + E S + KL++ E + ++
Sbjct: 1866 LENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEER 1925
Query: 762 EIEKNAESSKA----------SSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILK 811
+ + AE + + + I EL E+K NL++ +SE+ + K+ L KE ++
Sbjct: 1926 LMNQLAELNGSIGNYCQDVTDAQIKNELLESEMK--NLKKCVSELEEEKQQLVKEKTKVE 1983
Query: 812 EKFAEASEEAVSVQRSMQETVNKLH---------QKEEQFNMLSSDLEKLRENLADMEAK 862
+ + E +Q + +E NK H +K+++ L D + +E ++ +E
Sbjct: 1984 SEIRK--EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERT 2041
Query: 863 FR---------EKD-----EREEQLIKAKEKLENDIAEIMKMSGDNSSQLTK-MNDELRL 907
+ +KD E Q ++ ++K + ++A + D S+ + + D L+L
Sbjct: 2042 VKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 908 K---ERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 964
K + + E ++ ++ + +E+ + E+ +K +++ QE EK LE + +
Sbjct: 2102 KKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGE 2161
Query: 965 LEKKMETSHNQCQELKARYERATSETK--TKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
++ + + Q+L+ + ++ TK LQ+ + ++D + K R+ + +
Sbjct: 2162 IQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID--EAKKWERKFSDAI 2219
Query: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK-------QTNAKLQN 1075
+ EE+R + D +D ++ M +E ++ LE K QT +LQ
Sbjct: 2220 QSKEEEIRLKEDN---CSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ 2276
Query: 1076 EL-DTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENV 1134
++ DTL+ N + + +L +++ L ++ + E+++LK S L +E+
Sbjct: 2277 KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKG 2336
Query: 1135 KLAEELGRSRDEVT----SHQKLEEE----RSVLNNQLLEMKKRESKFIKDADEEKASLQ 1186
L + + ++ S+++LE + R + + E+ +E K I ++ ++Q
Sbjct: 2337 NLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ 2396
Query: 1187 KSISITSALLTEKDAELEKLRN-------EVTVLRGENASA-KSLHSVVQTLESDKVKLE 1238
+I + L + D E+++L N E VL EN A + +++TL++
Sbjct: 2397 VAI---AELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT------ 2447
Query: 1239 LKVKNLE--LQLKENKRQLSSSSGNTDTQADEDERAQESQIDFL---NSVIVDLQRKNQD 1293
+K +N++ QL + +SS + D + ++ +E + + + +I + +N
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 1294 LKMKVEMMSEAALNGNGDDLNN 1315
LK ++ L + DDLN+
Sbjct: 2508 LKEEIR-----GLRSHMDDLNS 2524
Score = 140 bits (354), Expect = 7e-33
Identities = 220/1039 (21%), Positives = 423/1039 (40%), Gaps = 151/1039 (14%)
Query: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
E++ E L + ++Q +L+A + + +++ R + EL N +E K+++ +
Sbjct: 976 ELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERG 1035
Query: 447 EESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEI 506
E K + E + S+ E+E L + E + +E D++ L+ ++
Sbjct: 1036 EVEEDKENKEYSEKCVTSKCQEIEIYLKQTISE-----KEVELQHIRKDLEEKLAAEEQF 1090
Query: 507 SSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATE----KLSKENESLKSK 562
+L +++ T D +I L+ + QK I + A++ L KE +
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPP 1150
Query: 563 LEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETA-------------- 608
+++ WK +LE I + ++ E+L+ + L + A
Sbjct: 1151 CTGSSEH-------WKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLRE 1203
Query: 609 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE-NSLEAI 667
E + K +++ + + + +N D R + E++ KL +++ +S +
Sbjct: 1204 ELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGL 1263
Query: 668 RSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKL 727
L KA +QH + N + ++ LQ + + +QLK E +
Sbjct: 1264 EEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTS-----VAQIKAQLKEIEAEK 1318
Query: 728 LDLDALRKASSEGK-----SEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGR 782
++L+ L+ +S+ + E+ +L++Q+ +I+ L+ + A S+ ++L+
Sbjct: 1319 VELE-LKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESS 1377
Query: 783 ELK------LTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM---QETVN 833
+L+ L LQ L E+ ++ E+++ L + +E +Q + ++ +
Sbjct: 1378 QLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIK 1437
Query: 834 KLH-QKEEQFNMLSSDLEKLRENLADMEAKFRE--KDEREEQ---------LIKAKEKLE 881
LH Q E Q +++L+ L +M+ K E ++ R +Q LI KE L+
Sbjct: 1438 ALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALK 1497
Query: 882 ND-------------IAEIMKMSGDNSSQLTKMNDE---------LRLKERD-------- 911
+ I + K D SQ++ N E L +ERD
Sbjct: 1498 ENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDR 1557
Query: 912 -----------VEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 960
E L+L L E+ L K IE + E +KH+E +KE E
Sbjct: 1558 SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEI 1617
Query: 961 KLSDLEK----------KMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTED 1010
L E +E + QEL + R+T K + E+ LQ ++ + + ++
Sbjct: 1618 LLQSYENVSNEAERIQHVVEAVRQEKQELYGKL-RSTEANKKETEKQLQEAEQEMEEMKE 1676
Query: 1011 KLKGAREENSGLLQELEEL--RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQ 1068
K++ + + ELEE R +A+ A TA++ M+ + E L ++ +
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 1069 TNAK----LQNELDTLKE--NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK 1122
T +K L +E D+L E +LK+ E N SK+ +K + E Q+ +
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGE 1796
Query: 1123 SQQLSALQ-------EENVKLAEELG-------RSRDEVTSHQKLEEERSVLNNQLLEMK 1168
+++ +L E+V A+ S DE+ ++ + ++ L E K
Sbjct: 1797 TEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEK 1856
Query: 1169 KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQ 1228
++ +F + + EK +L IS KD EL+ L+ EVT + N + S V
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQIS-------TKDGELKMLQEEVTKMNLLNQQIQEELSRVT 1909
Query: 1229 TLESDKVKLELKVKNLELQLKENKRQLSSSSGN---TDTQADEDERAQESQIDFLNSVIV 1285
L K E + +LE +L +L+ S GN T A ES++ L +
Sbjct: 1910 KL---KETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVS 1966
Query: 1286 DLQRKNQDL-KMKVEMMSE 1303
+L+ + Q L K K ++ SE
Sbjct: 1967 ELEEEKQQLVKEKTKVESE 1985
Score = 134 bits (338), Expect = 5e-31
Identities = 225/1075 (20%), Positives = 465/1075 (43%), Gaps = 165/1075 (15%)
Query: 353 LQEALKEKQQHIEQL-LAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMD 411
LQE + + EQ A+ +LE A H E+E++ + H+L L+
Sbjct: 338 LQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTS--------HILSLQKTGQ 389
Query: 412 QLRTMVEAADREKVELLNQLEEEK----RKVEDLQFRVEEES------ITKGDLEVATVS 461
+L++ +A + +LL E+ + ++ L+ +++++S + + L+ +
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 462 EKSRIMEL--EKDLALRVQEVAELRRRL-ESNKPAGDVDMSLSLLQEISSLQEKLEVTRT 518
++ ++ E A+ + +A L++R+ E G + +S L+E+ + EKL
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLS---- 505
Query: 519 DHQREITSLKEHFGAREETHQ-KEIKALYTATEKLSKENESLKSKLEHA----------- 566
+IT L+ E + EI + A ++ S ES + LE+
Sbjct: 506 ---SQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVL 562
Query: 567 ---NKENSDVIALWKSKLE--TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR 621
KE + IA K +L+ A + + +++ ++ +G G + +K +E
Sbjct: 563 LLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIK---MKVFLEDTG 619
Query: 622 LDYQ---HEIENL----QNQQDSERAAHAKEMEALR---AKLMKVIKEKENSLEAI---- 667
D+ +E +L + Q +E + E +L +L ++ + SL A+
Sbjct: 620 QDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG 679
Query: 668 ---RSKLDKAEDQHLVEMEDTLNKLQEA-----EIKVKELEVLQAKCNEQTKVIDNFTSQ 719
+ +L++ + Q ++E+E +K QE + K KE+ L E K DN +S
Sbjct: 680 QCHQDELERLKSQ-ILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSA 738
Query: 720 LKA-TEEKLLDLDALRKAS--SEGKSEMKKLRQQLEAAEKQIKHLEIEK-----NAESSK 771
A +EE+ L +++ S +E ++++K+L L AE+Q + L+ E N + +
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQ-RRLDYESQTAHDNLLTEQ 797
Query: 772 ASSITRELQGRELKLTNLQENL-------SEVSQVKETLEKELQILKEKFAEASEEAVSV 824
S++ E + +++K+ LQ L SE S + +L+ +LQ + + E +E +
Sbjct: 798 IHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHI 857
Query: 825 QRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
++E L QKE + + + L E D+E + +E+++Q+ + + +
Sbjct: 858 SSKVEELSQALSQKELEITKMD---QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKM 914
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
++ + ++ + ++L L R E + ++ + NE +S L+++ ++M+ + S+
Sbjct: 915 VQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISK 974
Query: 945 QE------AAKKHEEE-----------KKELERKLSDLEKKM--------------ETSH 973
+E KK E+ +KEL +++S LE+++ ET
Sbjct: 975 EELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETER 1034
Query: 974 NQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR---EENSGLLQELEELR 1030
+ +E K E + +K +EI L++T+ + E +L+ R EE ++ + L
Sbjct: 1035 GEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALV 1094
Query: 1031 KQADKAKAAQTAEDAMQIMEQMTKEKTETLASLED--TKQTNAKLQNELDTLKENNLKNV 1088
KQ + QT +D ++ + E +E A ++ T T+A + + +KE + +
Sbjct: 1095 KQMN-----QTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISP 1149
Query: 1089 EELNKSKELLTVENQKMEEFRKEIE----TLKQAAAQKSQQLSALQEENVKLAEELGRSR 1144
S+ +K+ KE E L++A + L QE+ L EEL + +
Sbjct: 1150 PCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQK 1209
Query: 1145 DEVTSHQKLEEERSVLNNQL------LEMKKRES---KFIKDADEEKASLQKSISITSAL 1195
D+ Q+ +E+S N + L+++ RES K +E S +
Sbjct: 1210 DDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK 1269
Query: 1196 LTEKDAELEKLRN-----------EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNL 1244
TE+ L + + + L+G S + + ++ +E++KV+LELKV +
Sbjct: 1270 ATEQHHTQPVLESNLCPDWPSHSEDASALQG-GTSVAQIKAQLKEIEAEKVELELKVSST 1328
Query: 1245 ELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
+L + ++ Q E Q +I+ L +V + + + L+ K+E
Sbjct: 1329 TSELTKKSEEV--------FQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Score = 117 bits (293), Expect = 8e-26
Identities = 212/1039 (20%), Positives = 425/1039 (40%), Gaps = 216/1039 (20%)
Query: 314 SSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT---------------TALQEALK 358
S+++ +++ S+SS + + + ++ RK S + L++ L+
Sbjct: 2182 STVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLR 2241
Query: 359 EKQQHIEQLLA-----ERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
+ H+E+L E D + E +KA + V +++Q++ G ++ EL +++++
Sbjct: 2242 QMSIHMEELKINISRLEHDKQIWE-SKAQTEV-QLQQKVCDTLQGENK---ELLSQLEET 2296
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELE--- 470
R + ++ E +L ++L+ K ++ DL +E+ KG+LE +++ I +
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 471 KDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEH 530
+ L +Q EL RL + + L + ++Q + R H +EI L+
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENL 2416
Query: 531 FGAREETH---QKEIKALYTATEKL-------SKENESLKSKLEHANKENSDV------- 573
EE + ++E K T +L KEN K++L+ K S +
Sbjct: 2417 LSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRI 2476
Query: 574 -------------IALWKSKL-ETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
I L K +L + A A + + EE++ + +E A+L ++ +
Sbjct: 2477 VGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIR-GLRSHMDDLNSENAKLDAELIQ 2535
Query: 620 MRLDYQHEI---ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED 676
R D I ++ Q Q + KE+E AKL + +KE E + E +R + ++
Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 677 QHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKA 736
E +D +++ ++ + +L Q ++ + + +QLK EE++ L AL +
Sbjct: 2596 ----EKQDLSKEIESLKVSISQL-TRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSS 2650
Query: 737 SSEGKSEMKK---------------------------------LRQQLEAAEKQIKHLEI 763
S + +E+++ +R + E AE+++ L
Sbjct: 2651 SQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELAR 2710
Query: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKF--------- 814
+ K +T+E +G ++ + ++S + ++ +EL LK K+
Sbjct: 2711 DLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQ 2770
Query: 815 ------------AEASEEAVSVQRSMQETVNKLHQ-------KEEQFNMLSSDLEKL--- 852
A SE A S+ + + +++ L + K+EQ LSS LE
Sbjct: 2771 LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQ 2830
Query: 853 --------------RENLADMEAKFREKDEREEQ--------------LIKAKEKLENDI 884
R++L + KFR+ +E +++ L KA L+ND
Sbjct: 2831 VQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDR 2890
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMT------- 937
++K + Q ++N E+ ++ L+ +L + + Q E++
Sbjct: 2891 DRLLKELKNLQQQYLQINQEIT----ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQ 2946
Query: 938 -----VKAEQSQQEAAKKHEEEK-----KELERKLSDLE---KKMETSHNQCQELKARYE 984
++ E+S E ++ +E+ + +++LS L+ +++ +S +Q Q LK +Y+
Sbjct: 2947 HELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQ 3006
Query: 985 RATSETKTKHEEILQNL--QKTLLDTE--DKLKGAREENSGLLQELEELRKQADKAKAAQ 1040
R S + + QNL + LL T+ D LK + +ELR Q + +Q
Sbjct: 3007 RQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQ---------KELRIQQLNSNFSQ 3057
Query: 1041 TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV 1100
E+ + Q+ +T SL + +Q L N L+ K V+EL + V
Sbjct: 3058 LLEEKNTLSIQL----CDTSQSLRENQQHYGDLLNHCAVLE----KQVQELQAGPLNIDV 3109
Query: 1101 ----ENQKMEEFRK----EIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQK 1152
+K RK E+ +Q+ ++ QQL ++E +L + L RD+ +
Sbjct: 3110 APGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRVA--- 3166
Query: 1153 LEEERSVLNNQLLEMKKRE 1171
E SV Q+ ++ E
Sbjct: 3167 AENALSVAEEQIRRLEHSE 3185
Score = 102 bits (254), Expect = 3e-21
Identities = 176/870 (20%), Positives = 367/870 (42%), Gaps = 136/870 (15%)
Query: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANK---ENSDVIALWKSKLETAIASHQQAM 592
E HQ+ T+ E ++ +L +A + E D+I +L+ + Q+
Sbjct: 33 ELHQESDMEFNNTTQ------EDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEER 86
Query: 593 EELKVSFSKGLGTETAEFAELKTQIEKMR------LDYQHEIENLQNQQDSERAAHAKEM 646
+ K A+ L IE+M+ L + + E ++ D E+
Sbjct: 87 KAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEI 146
Query: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAED----QHLVEMEDTLNKLQEAEIKVKELEVL 702
E ++ KL +EKE + ++++L +A+ Q EME+ + Q+ + K + + L
Sbjct: 147 EKIKHKL----QEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 703 QAKCNE-------QTKVIDN---FTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
QA+ ++ Q V + F +Q++ E++LL L +E + +++ L+++LE
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE 262
Query: 753 AAEKQ-------IKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEK 805
E+ + L+ E A + ++++LQ E + L+ + ET +
Sbjct: 263 EHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTV-------ETERE 315
Query: 806 ELQILKEKFA-EASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFR 864
E +IL EK E +E +S +E +H EQF +L + +E K +
Sbjct: 316 ESKILLEKMELEVAERKLSFHNLQEE----MHHLLEQFEQAGQAQAELESRYSALEQKHK 371
Query: 865 EKDEREEQLIKAKEKLENDIAEIM-KMSGDNSSQLTKMNDELRLKERDVEELQLKL-TKA 922
+ E + I + +K ++ + NS L N++ + +++L+ +L K+
Sbjct: 372 AEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKS 431
Query: 923 NENASFL------QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKK---METSH 973
E + FL Q T + + EE L++++ +LE + + S
Sbjct: 432 KEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSS 491
Query: 974 NQCQELKARYERATS-----ETKTKHEEILQNLQK-TLLDTEDKLKGAREEN-------- 1019
+ +ELKA E+ +S E + + E + + + +++D +K + EE+
Sbjct: 492 IELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENT 551
Query: 1020 --------SGLLQELEELRKQAD------KAKAAQTAEDAMQIMEQMTKEKTETLAS--- 1062
S LL E++E +++ + K A+ A+ + ++M + + E +A
Sbjct: 552 FSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKM 611
Query: 1063 ---LEDTKQTNAKLQNELDTLK--ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
LEDT Q + NE +L E + E +++ E +++ + +E LK
Sbjct: 612 KVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE--------LKS 663
Query: 1118 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQ-KLEEERSVLNNQLLEMKKRESKFIK 1176
+ LSA+ + +EL R + ++ + + + + L E K S +
Sbjct: 664 TKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQ 723
Query: 1177 DADEEKASLQKSISITSALLTEKDAELEKLR--NEVTVLRGE-----------------N 1217
+E K + + S +AL E+D L +++ + VT LR + +
Sbjct: 724 LIEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLD 783
Query: 1218 ASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKR---QLSSSSGNTDTQADEDERAQE 1274
+++ H + T + + +E K K++++++ +N+ QL S +T R+ +
Sbjct: 784 YESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLI------RSLQ 837
Query: 1275 SQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
SQ+ S +++ + + + KVE +S+A
Sbjct: 838 SQLQNKESEVLEGAERVRHISSKVEELSQA 867
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 171 bits (433), Expect = 4e-42
Identities = 219/1034 (21%), Positives = 455/1034 (44%), Gaps = 145/1034 (14%)
Query: 353 LQEALKEKQQHIEQLLAERDLER--AEVAKA-------TSHVGEIEQELALARDGH---- 399
LQEA ++IE L D R +E+ K+ + + +E+EL LARD +
Sbjct: 993 LQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENC 1052
Query: 400 ------DQHVLELEAKMDQLRTMVEAAD--REKVEL------------LNQLEEEKRKVE 439
DQ++ + +A+ Q + + + + + + EL Q++E K+
Sbjct: 1053 NKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKIT 1112
Query: 440 DLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS 499
L + +E+E + +E +K+ +L+K + + ++LES K + +
Sbjct: 1113 RLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLG--WQKLESEKAIKEKEYE 1170
Query: 500 LSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAR----EETHQKEIKALYTATEKLSKE 555
+ L+ + LQE+ + +++ E+ ++ H+ ++ EI T +++S +
Sbjct: 1171 IERLRVL--LQEE-GTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQ 1227
Query: 556 NE----SLKSKLEHANKENSD----VIALWKSKLETAIASHQQAMEELKVSFSKGLGTET 607
E +L+++L+ ++EN D ++ L S L+ A+ Q+ E K G+E
Sbjct: 1228 KEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQ---ATEQRRRAEENALQQKACGSEI 1284
Query: 608 AEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA-----KEMEALRAKLMKVIK---E 659
+ + +IE ++ Q +N +++Q E AA KE+E L+A+ + K E
Sbjct: 1285 MQ-KKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE 1343
Query: 660 KENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKV------I 713
EN L +R+ D+ ++ +++ E EI + + + Q ++ I
Sbjct: 1344 YENELSKVRNNY----DEEIISLKNQF----ETEINITKTTIHQLTMQKEEDTSGYRAQI 1395
Query: 714 DNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQI----KHLEIE-KNAE 768
DN T + ++ E++ L ++E +++ QQ +A ++ + LE+E +
Sbjct: 1396 DNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVT 1455
Query: 769 SSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKEL---QILKEKFAEASEEAVSVQ 825
+ R Q + +Q+ E+ ++K+ ++KE + L+++ A +Q
Sbjct: 1456 QMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQ 1515
Query: 826 R---SMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEN 882
+ S ET+NKL +E++ L D E++ + + ++L K+K+E
Sbjct: 1516 KANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEE 1575
Query: 883 DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLK---LTKANENASFLQKSIEDMT-- 937
++ + + + ++S + K+ +EL R ++E +K LT+ E AS ++K ED
Sbjct: 1576 ELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQ 1635
Query: 938 --------VKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE---RA 986
++ +Q QE ++ E + L R+L ++ ++ +H + + + E R+
Sbjct: 1636 QRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRS 1695
Query: 987 TSETKTKHE---EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAE 1043
+E+K + E + +NL K L E++L+ R E +L R +AD K A E
Sbjct: 1696 LNESKIEIERLQSLTENLTKEHLMLEEELRNLRLE----YDDLRRGRSEADSDKNATILE 1751
Query: 1044 DAMQIMEQMTKEKTETLASL-EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVEN 1102
Q+ Q++ +T L L D ++ L+ E++ ++ L+ + +SK T
Sbjct: 1752 LRSQL--QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVV 1809
Query: 1103 QKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD----EVTSHQKLEEERS 1158
Q+ E +I+ L+Q A+ +L +EL R++ E Q+LE E+
Sbjct: 1810 QERESLLVKIKVLEQDKARLQ-----------RLEDELNRAKSTLEAETRVKQRLECEKQ 1858
Query: 1159 VLNNQLLEMK----KRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLR 1214
+ N L + K ++E K E + S ++ S+ S E+E+L+ E+ R
Sbjct: 1859 QIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRS--------EIERLQAEIK--R 1908
Query: 1215 GENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQE 1274
E + L + +S +LE + + ++ + +++ S T T+ + +
Sbjct: 1909 IEERCRRKLEDSTRETQS---QLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSK 1965
Query: 1275 SQIDFLNSVIVDLQ 1288
D L + +Q
Sbjct: 1966 LVFDGLRKKVTAMQ 1979
Score = 144 bits (363), Expect = 6e-34
Identities = 216/1045 (20%), Positives = 439/1045 (42%), Gaps = 211/1045 (20%)
Query: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAK----ATSHVGEIEQELALARDGHDQ 401
K + + L E++ ++ +RD + EV K + + + E +LA G +
Sbjct: 916 KFGDSNTVMRFLNEQKNLHSEISGKRD-KSEEVQKIAELCANSIKDYELQLASYTSGLET 974
Query: 402 HVLELEAKMDQLRT-----MVEAAD--REKVELLNQ-------LEEEKRKVEDLQFRVEE 447
+L + K +++ + EAAD +ELL + L E + +EDL+ + +
Sbjct: 975 -LLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTK 1033
Query: 448 ESITKGDLEVATVSE-----KSRIME--LEKDLA------LRVQEVAELRRR--LESNKP 492
+ + +L +A + K++ ++ L+K A ++ + EL+R+ L+
Sbjct: 1034 IEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSA 1093
Query: 493 AGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKL 552
++D ++E++ +L D +R S+++ F ++ + + KA
Sbjct: 1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKA-------- 1145
Query: 553 SKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAE 612
KEN + K + E AI + +E L+V + GT E+
Sbjct: 1146 -----------RQCEKEN---LGWQKLESEKAIKEKEYEIERLRVLLQEE-GTRKREY-- 1188
Query: 613 LKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD 672
+ ++ K+R Y E+ NL+N+ ++E + + + ++ +KE+ + +R++LD
Sbjct: 1189 -ENELAKVRNHYNEEMSNLRNKYETE-------INITKTTIKEISMQKEDDSKNLRNQLD 1240
Query: 673 KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA 732
+ ++ +++D + +L ++ +LQA T Q + EE L A
Sbjct: 1241 RLSRENR-DLKDEIVRLNDS--------ILQA------------TEQRRRAEENALQQKA 1279
Query: 733 LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKA-SSITRELQGRELKLTNLQE 791
SE+ + +Q LE KQ+ E NA ++ + +Q + ++ L+
Sbjct: 1280 CG-------SEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKA 1332
Query: 792 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVN----KLHQ----KEEQFN 843
E ++ + E EL ++ + EE +S++ + +N +HQ KEE +
Sbjct: 1333 EFQEEAKRRWEYENELSKVRNNY---DEEIISLKNQFETEINITKTTIHQLTMQKEEDTS 1389
Query: 844 MLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMND 903
+ ++ L + + + Q + ++E DI + K +G SQ
Sbjct: 1390 GYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQ-QKATGSEVSQ------ 1442
Query: 904 ELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS 963
R ++ +VE Q+ + E+ V+ +QS +AAK +++ KE+ER
Sbjct: 1443 --RKQQLEVELRQVTQMRTEES------------VRYKQSLDDAAKTIQDKNKEIERLKQ 1488
Query: 964 DLEKKMETSHNQC-QELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGL 1022
++K ET+ +C ++ AR +R + LQ + +T +KLK
Sbjct: 1489 LIDK--ETNDRKCLEDENARLQRVQYD--------LQKANSSATETINKLKVQE------ 1532
Query: 1023 LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKE 1082
QEL LR ++ +T +D Q + QN L L+
Sbjct: 1533 -QELTRLRIDYERVSQERTVKD-----------------------QDITRFQNSLKELQL 1568
Query: 1083 NNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQK-------SQQLSALQEENVK 1135
K EELN+ K + ++ K ++ +E+E ++++ ++ +QQL +
Sbjct: 1569 QKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKR 1628
Query: 1136 LAEELGRSRDEVTSH----QKLEEERSVLNNQLLEMKK---RESKFIKDADEEKASLQKS 1188
++L + RD + H Q+ +EE L++++ +++ +E + +K A QK+
Sbjct: 1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKA 1688
Query: 1189 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1248
I S L E E+E+L+ S+ + L + + LE +++NL L+
Sbjct: 1689 IEDKSRSLNESKIEIERLQ-----------------SLTENLTKEHLMLEEELRNLRLEY 1731
Query: 1249 KENKRQLSSSSGNTDTQADEDERAQESQID-----FLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ +R S ++D A E + QI L +I DLQR+ ++L+ ++E +
Sbjct: 1732 DDLRR--GRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQK 1789
Query: 1304 AALNGNG---DDLNNYDSDDQEKQS 1325
AL + + N QE++S
Sbjct: 1790 QALEASNRIQESKNQCTQVVQERES 1814
Score = 108 bits (271), Expect = 3e-23
Identities = 162/792 (20%), Positives = 333/792 (42%), Gaps = 130/792 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
++ + S AR + +++K + IE+L +AE + E E EL+
Sbjct: 1298 VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERL-------KAEFQEEAKRRWEYENELSK 1350
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
R+ +D+ ++ L+ +Q T + +L Q EE+ +R + +++T+
Sbjct: 1351 VRNNYDEEIISLK---NQFETEINITKTTIHQLTMQKEEDTSG-----YRAQIDNLTR-- 1400
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLE 514
E + E K L + + E RR+E D+ + E+S +++LE
Sbjct: 1401 -------ENRSLSEEIKRLKNTLTQTTENLRRVEE-----DIQQQKATGSEVSQRKQQLE 1448
Query: 515 VTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVI 574
V R++T ++ R + ++L A + + +N+ ++ + +KE +D
Sbjct: 1449 V----ELRQVTQMRTEESVRYK------QSLDDAAKTIQDKNKEIERLKQLIDKETND-- 1496
Query: 575 ALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ-IEKMRLDYQH-EIENLQ 632
+ LE A Q+ +L+ + S TET +++ Q + ++R+DY+ E
Sbjct: 1497 ---RKCLEDENARLQRVQYDLQKANSSA--TETINKLKVQEQELTRLRIDYERVSQERTV 1551
Query: 633 NQQDSERAAHA-KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
QD R ++ KE++ + K+ + + + + K K E+ E+E L+E
Sbjct: 1552 KDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEE----ELEGMRRSLKE 1607
Query: 692 AEIKVKEL--EVLQAKC---------NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG 740
IK+ L ++ QA +Q V+D + + T+E+L L
Sbjct: 1608 QAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS--------- 1658
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
SE++ LR+QL ++ +K + +R L ++++ LQ +++
Sbjct: 1659 -SEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEH 1717
Query: 801 ETLEKELQILKEKF-------AEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLR 853
LE+EL+ L+ ++ +EA + + ++ + + + + L +DL++ R
Sbjct: 1718 LMLEEELRNLRLEYDDLRRGRSEADSDKNATILELRSQLQISNNRTLELQGLINDLQRER 1777
Query: 854 ENLADMEAKFREK-------------------DEREEQLIKAKEKLENDIAEIMKMSGDN 894
ENL KF+++ ERE L+K K LE D A + ++ +
Sbjct: 1778 ENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKV-LEQDKARLQRLEDEL 1836
Query: 895 SSQLTKMNDELRLKER-DVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEE 953
+ + + E R+K+R + E+ Q++ + +K +EA +K E
Sbjct: 1837 NRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRK-------------EEAIRKIES 1883
Query: 954 EKKELERKLSDLEKKMETSHNQCQELKARYER----ATSETKTKHEEILQNLQKTLLDTE 1009
E+++ ER+ + L ++E + + ++ R R +T ET+++ E Q+ +
Sbjct: 1884 EREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLR 1943
Query: 1010 DKLKGAREENSGLLQELEELRKQADKAK----AAQTAEDAMQIMEQMTKEKTETLASLED 1065
+ G+ E E D +K + AMQ+ E +KT TL L
Sbjct: 1944 QRPYGSHRETQ------TECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKT-TLDKLLK 1996
Query: 1066 TKQTNAKLQNEL 1077
K++ ++ +E+
Sbjct: 1997 GKKSVEEVASEI 2008
Score = 30.8 bits (68), Expect = 9.5
Identities = 29/159 (18%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 931 KSIEDMTVKAEQ---SQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERAT 987
K+I D+ + ++ + Q + +++K++++ + +D +K +T Q +++ T
Sbjct: 578 KTIADLELHYQEFIRNSQGSEMFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYP-QHQTVT 636
Query: 988 SETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAED--- 1044
+ T H +++T + ++ + +L EL+++R+Q + + T ++
Sbjct: 637 TTEITHHGTCQDVNHNKVIETN---RENDKQETWMLMELQKIRRQIEHCEGRMTLKNLPL 693
Query: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKEN 1083
A Q K L S+++ Q A++ N+L + N
Sbjct: 694 ADQGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLAN 732
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 171 bits (433), Expect = 4e-42
Identities = 238/1075 (22%), Positives = 475/1075 (44%), Gaps = 138/1075 (12%)
Query: 323 ASSVSSRPSRTGLLTETSSRYARKISGTTA---LQEALKEKQQHIEQLL-AERDLERAEV 378
ASS + P + + T SR + A ++ +E ++ EQLL +++LE+ E+
Sbjct: 227 ASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEI 286
Query: 379 AKATSHVGEIEQE-LALARDGHDQHVLELEAKMDQLRTMVEAADREKVEL------LNQL 431
+ ++QE + L D + E +D LR D+ + E+ L+ +
Sbjct: 287 -----ELKRLQQENMNLLSDARSARMYRDE--LDALREKAVRVDKLESEVSRYKERLHDI 339
Query: 432 EEEKRKVEDL----QFRVEEESITKGDLEVATVSEKSRIMELEKD---LALRVQEVAELR 484
E K +VE+L Q +E +++ + LE T + ++ ELEK+ L ++ ++ E+
Sbjct: 340 EFYKARVEELKEDNQVLLETKTMLEDQLE-GTRARSDKLHELEKENLQLKAKLHDM-EME 397
Query: 485 RRLESNK--PAGDVDMSLSLLQEISSLQEKL-------EVTRTDHQREITSLKEHFGARE 535
R ++ K + +M+L + Q+ S+ E L +++RT E E
Sbjct: 398 RDMDRKKIEELMEENMTLEMAQK-QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
Query: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK---------LETAIA 586
T + +K L + L+K E L++ ++ S ++ + K LE I
Sbjct: 457 LTSSRLLK-LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
Query: 587 SHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQD--SERAAHAK 644
+Q+++ + + SK L E A+ L+ IE +R + + +I+ L+ + + ++ + +
Sbjct: 516 QEKQSLQNCQ-NLSKDLMKEKAQ---LEKTIETLRENSERQIKILEQENEHLNQTVSSLR 571
Query: 645 EMEALRAKLMKVIKEKEN-----SLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKEL 699
+ + A+ EKEN S++ SKL K E + +++ L +E + +EL
Sbjct: 572 QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR-QIKKELEHYKEKGERAEEL 630
Query: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQ---------- 749
E ++ +++ + LK T EK+ +AL + +SE + E +KL++
Sbjct: 631 ENELHHLEKENELLQKKITNLKITCEKI---EALEQENSELERENRKLKKTLDSFKNLTF 687
Query: 750 QLEAAEKQI-----KHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLE 804
QLE+ EK+ ++LE+ +N ES K +S +K+ LQ E+ KE L+
Sbjct: 688 QLESLEKENSQLDEENLELRRNVESLKCAS---------MKMAQLQLENKELESEKEQLK 738
Query: 805 KELQILKEKFAEASEEAVSVQ------RSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD 858
K L++LK F + VS Q + +Q+T+ ++K +Q DLE + L
Sbjct: 739 KGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
Query: 859 MEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR----LKERDVEE 914
+ + +R EQL K + LE + +++ K + QL K N LR +K+ +EE
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEK----DKKQLEKENKRLRQQAEIKDTTLEE 854
Query: 915 LQLKLTKANENASFLQKSI---EDMTVKAEQSQQEAAK---------------------- 949
+K+ + L K I ++ V+ ++ ++E +
Sbjct: 855 NNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE 914
Query: 950 --KHEEEKKELERKLSDLEK----KMETSHNQCQELKARYERATSETKTKHEEILQNLQK 1003
K ++ +LE+ +LEK K H++ +RY+ S+ ++ ++ L+ ++
Sbjct: 915 KLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 1004 TLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASL 1063
+ E +L+ + N L QEL+ ++K + K Q E +Q ++ E +
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 1064 EDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKS 1123
++T + K+++ L ++ NN E K L + + +I L++
Sbjct: 1035 QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 1124 QQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKA 1183
+Q + LQ +N KL E + TS L + + L Q ++ IK+ ++ K+
Sbjct: 1095 EQNTTLQTQNAKLQVENSTLNSQSTS---LMNQNAQLLIQQSSLENENESVIKEREDLKS 1151
Query: 1184 ---SLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELK 1240
SL K L + +E E L ++ L+ + + + H ++ + +K + +
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 1241 VKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLK 1295
+++LE LK + ++ + N +T A E ++ + D LN L ++ + L+
Sbjct: 1212 LEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC-GENDRLNHTYSQLLKETEVLQ 1265
Score = 148 bits (374), Expect = 3e-35
Identities = 241/1112 (21%), Positives = 478/1112 (42%), Gaps = 155/1112 (13%)
Query: 334 GLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELA 393
GL +T + A I T QE + + Q +++ D+E + H+ + E
Sbjct: 147 GLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPL-LKNMALHLKRLIDE-- 203
Query: 394 LARDGHDQHVLELEAKMDQLRTMVEAAD--------------REKVELLNQLEEEKRKVE 439
RD H + ++EL + D L + A+ + L +L + K K+
Sbjct: 204 --RDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIR 261
Query: 440 DLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMS 499
L+ +EE++ D K + ++E +L QE L S + D
Sbjct: 262 RLRQELEEKTEQLLDC-------KQELEQMEIELKRLQQENMNLLSDARSARMYRD---E 311
Query: 500 LSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESL 559
L L+E + +KLE + ++ + + E + AR E +++ + L L + E
Sbjct: 312 LDALREKAVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
Query: 560 KS---KLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQ 616
++ KL KEN + K+KL ++++ + + T E A+ ++
Sbjct: 371 RARSDKLHELEKENLQL----KAKLHDMEMERDMDRKKIEELMEENM---TLEMAQKQSM 423
Query: 617 IEKMRLDYQ-HEIENLQNQQDSERAAHAKEM-EALRAKLMKVIKEKENSLEAIRSKLDKA 674
E + L ++ +I ++ + + E+ E ++L+K+ E ++ + +
Sbjct: 424 DESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVE------ 477
Query: 675 EDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALR 734
E+ T++ ++ K+ ++E + +++ ++++N ++ ++ L + L
Sbjct: 478 ------ELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN---EIVQEKQSLQNCQNLS 528
Query: 735 KASSEGKSEMKKLRQQL-EAAEKQIKHLEIEKNAESSKASS------ITRELQGRELKLT 787
K + K++++K + L E +E+QIK LE E + SS I+ E + ++++
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 788 N--LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNML 845
N L E++ E S +E E + +K++ E+ +E N+LH E++ +L
Sbjct: 589 NKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG----ERAEELENELHHLEKENELL 644
Query: 846 SSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
+ L+ +EA +E E E + K K+ L D+ LT + L
Sbjct: 645 QKKITNLKITCEKIEALEQENSELERENRKLKKTL------------DSFKNLTFQLESL 692
Query: 906 RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965
+ ++E L+L + E S++ ++K Q Q E K+ E EK++L++ L
Sbjct: 693 EKENSQLDEENLELRRNVE-------SLKCASMKMAQLQLE-NKELESEKEQLKKGL--- 741
Query: 966 EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQE 1025
+ ++ S + + L+ Y+ E + + ++ L+N K + E +L+ EN L +
Sbjct: 742 -ELLKASFKKTERLEVSYQGLDIENQ-RLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 1026 LEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLE-DTKQTNAKLQNELDTLKENN 1084
LEEL+ +K + E + +EQ T + + LE + K+ + + + TL+ENN
Sbjct: 800 LEELK---ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
Query: 1085 LK--NVEELNK--SKELLTVENQ--KMEEFRKEIETLKQAAAQKSQQLSALQEENV--KL 1136
+K N+E+ NK SKE+ + +++E KE + L + A + L L+E+ V KL
Sbjct: 857 VKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKL 916
Query: 1137 AEELGRSRDEVTSHQKLEEERSVLNNQLL---EMKKRESKFIKDADEEKASLQKSISITS 1193
+ + E +H E E+ LN + L E +S++ + +++L+KS+ I
Sbjct: 917 KTQQMNNDLEKLTH---ELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKE 973
Query: 1194 ALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLE--------------- 1238
+ +A LE+ N LR E + K + ++ + ++ ++
Sbjct: 974 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1033
Query: 1239 --------LKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQ---ESQIDFLNSVIVDL 1287
LKVK+ ++++ N L + TQ + E ++QI L V L
Sbjct: 1034 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1093
Query: 1288 QRKN-----QDLKMKVE-----MMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICD 1337
Q +N Q+ K++VE S + +N N L S + E +S K R D+
Sbjct: 1094 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE--DLKS 1151
Query: 1338 CFDL----HDTEDCPTQAQMSEDPPHSTHHGS 1365
+D H+ + + Q SE + HG+
Sbjct: 1152 LYDSLIKDHEKLELLHERQASEYESLISKHGT 1183
Score = 74.3 bits (181), Expect = 7e-13
Identities = 190/978 (19%), Positives = 382/978 (39%), Gaps = 137/978 (14%)
Query: 355 EALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQE---LALARDGHDQHVLELEAKMD 411
E LK + +EQL E E ++ ++E+E L + D + E K+
Sbjct: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860
Query: 412 QLRTMVEAADRE---KVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIME 468
L + +E E +L+E +++ ++L R + T L VSEK + +
Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
Query: 469 LEKDLALRVQEVAEL----RRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 524
+ DL E+ ++ R L + D L + S+L++ LE+
Sbjct: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALE 980
Query: 525 TSLKEHFGAREETHQ--KEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 582
L+E ++ Q K +K Y A ++ E ++S + ++N W+ + +
Sbjct: 981 ARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK-----WERESQ 1035
Query: 583 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMR----------LDYQHEIENLQ 632
+ + L + + T AE LKTQ++++ L Q + +LQ
Sbjct: 1036 ETTRELLKVKDRL-IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1094
Query: 633 NQQDSERAAHAK-EMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQE 691
Q + + +AK ++E +N+ I+ + E++ +++ + L L +
Sbjct: 1095 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1154
Query: 692 AEIKVKE-LEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 750
+ IK E LE+L + + + + + LK+ + +L+ + + +++ K + Q
Sbjct: 1155 SLIKDHEKLELLHERQASEYESLISKHGTLKSAHK---NLEVEHRDLEDRYNQLLKQKGQ 1211
Query: 751 LEAAEKQIKHLEIEK----NAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
LE EK +K +E EK N ++ ++L G +L + L + ++V +T K
Sbjct: 1212 LEDLEKMLK-VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1270
Query: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
L+ L + +S LE+ R +EA+F +
Sbjct: 1271 LKSL---------------------------------LNNSKLEQTR-----LEAEFSKL 1292
Query: 867 DEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENA 926
E+ +QL KL N + ++ G+ + + D+++ T +N
Sbjct: 1293 KEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ-------------TLMLQNR 1339
Query: 927 SFLQKSIEDMTVKAEQSQQEAAKKHE--EEKKELERKLSDLEKKMETS----HNQCQELK 980
+ L++++E + + +Q K +E +K++LE K+ D K + S LK
Sbjct: 1340 TLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK 1399
Query: 981 ARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQ 1040
R K+K ++I + QK+L L R ++S +L Q + +
Sbjct: 1400 MR-----KLIKSK-KDINRERQKSL-----TLTPTRSDSSEGFLQLPHQDSQDSSSVGSN 1448
Query: 1041 TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV 1100
+ ED + + + + + S+ Q + NL+ ++++ K +
Sbjct: 1449 SLEDGQTLGTKKSSTMNDLVQSMVLAGQWTGSTE---------NLEVPDDISTGKRRKEL 1499
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL---GRSRDEVTSHQ------ 1151
T+ +A +S+QL + ++ E++ G S D T +
Sbjct: 1500 GAMAFSTTAINFSTVNSSAGFRSKQL--VNNKDTTSFEDISPQGVSDDSSTGSRVHASRP 1557
Query: 1152 -KLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEV 1210
L+ R+ +N E K A ++ Q S +LL + +A + +
Sbjct: 1558 ASLDSGRTSTSNSNNNASLHEVK--AGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPI 1615
Query: 1211 TVLRGENASAKSL-HSVVQTLESDKVKLELKVKNLEL----QLKENKRQLSS---SSGNT 1262
L+ + S+ L H + +TLES K++ E+ Q E +L+S S +
Sbjct: 1616 QYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQ 1675
Query: 1263 DTQADEDERAQESQIDFL 1280
+ DE ++ DFL
Sbjct: 1676 ENLLDEVMKSLSVSSDFL 1693
Score = 62.8 bits (151), Expect = 2e-09
Identities = 120/518 (23%), Positives = 205/518 (39%), Gaps = 104/518 (20%)
Query: 790 QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDL 849
QE L ++ + +L L I K F+E E V + QK+E+F +
Sbjct: 91 QETLQQL--IMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEF------I 142
Query: 850 EKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK- 908
E+++ D + K +E + + E+ MS ++ L K N L LK
Sbjct: 143 ERIQG--LDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLK-NMALHLKR 199
Query: 909 ---ERDVE-ELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSD 964
ERD E ++L++ + FL + + A+ K E ++ L +L+D
Sbjct: 200 LIDERDEHSETIIELSEERDGLHFLPHA----SSSAQSPCGSPGMKRTESRQHLSVELAD 255
Query: 965 LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ 1024
KA+ R E + K E++L Q+ L E +LK ++EN LL
Sbjct: 256 A--------------KAKIRRLRQELEEKTEQLLDCKQE-LEQMEIELKRLQQENMNLLS 300
Query: 1025 ELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENN 1084
+ R D+ A + E A+++ KL++E+ KE
Sbjct: 301 DARSARMYRDELDALR--EKAVRV----------------------DKLESEVSRYKER- 335
Query: 1085 LKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSR 1144
L ++E E L +NQ + E + +E + +S +L L++EN++L +L
Sbjct: 336 LHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDME 395
Query: 1145 DEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
E +K EE + N LEM +++S D + IS TS L
Sbjct: 396 MERDMDRKKIEEL-MEENMTLEMAQKQSM---DESLHLGWELEQISRTSEL--------- 442
Query: 1205 KLRNEVTVLRGENASAKSL-HSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTD 1263
A KSL H V + S +KLE++ ++L ++E + + S GN
Sbjct: 443 -----------SEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNA- 490
Query: 1264 TQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMM 1301
S I+ ++++NQ L KVE++
Sbjct: 491 ------------------SKILKMEKENQRLSKKVEIL 510
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1297 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1351
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1406
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1467 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1577 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1628
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1687
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1863
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2044 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2158
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1731 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1777
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1837 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1896 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2128
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2129 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2184
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2185 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2225
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2450
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2451 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2493
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2551 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2600
Query: 1230 LE 1231
LE
Sbjct: 2601 LE 2602
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1909
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1910 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1957
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2018 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2075 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2194 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2248 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2356
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2415
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2534
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2631
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1089 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1128
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1129 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1183 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1234
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1235 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1284
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1285 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1339 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1394 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1629 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1676
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1677 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1733 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1783
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1784 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAE 1987
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1162
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1281
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1282 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1398
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1516
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVA 1602
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1301 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1355
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1356 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1410
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1471 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1581 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1632
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1633 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1691
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1692 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1751
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1752 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1811
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1812 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1867
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2048 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2106
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2107 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2162
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2262
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1735 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1781
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1840
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1841 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1900 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1956
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1957 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2132
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2133 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2188
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2189 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2229
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2230 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2409
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2410 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2454
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2455 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2497
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2498 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2554
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2555 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2604
Query: 1230 LE 1231
LE
Sbjct: 2605 LE 2606
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1801 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1860
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1861 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1913
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1914 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1961
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2022 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2079 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2197
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2198 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2251
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2252 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2302
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2303 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2360
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2361 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2419
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2538
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2539 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2635
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1093 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1132
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1133 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1186
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1187 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1238
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1239 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1288
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1289 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1343 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1397
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1398 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1454
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1455 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1514
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1515 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1572
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1632
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1633 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1680
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1681 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1736
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1737 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1787
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1788 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAE 1991
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 991 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1050
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1051 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1110
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1166
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1167 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1226
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1227 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1285
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1286 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1343
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1402
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1403 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1462
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1463 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1520
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVA 1606
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1297 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1351
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1406
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1467 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1577 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1628
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1629 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1687
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1688 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1747
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1748 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1807
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1808 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1863
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2044 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2102
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2103 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2158
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2258
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1731 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1777
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1836
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1837 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1896 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1952
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1953 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2128
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2129 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2184
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2185 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2225
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2226 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2405
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2406 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2450
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2451 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2493
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2494 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2550
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2551 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2600
Query: 1230 LE 1231
LE
Sbjct: 2601 LE 2602
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1797 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1856
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1857 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1909
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1910 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1957
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2018 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2075 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2193
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2194 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2247
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2248 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2298
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2299 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2356
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2357 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2415
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2534
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2535 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2631
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1089 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1128
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1129 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1182
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1183 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1234
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1235 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1284
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1285 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1339 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1393
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1394 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1450
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1451 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1510
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1511 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1568
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1628
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1629 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1676
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1677 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1732
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1733 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1783
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1784 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAE 1987
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1162
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1163 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1222
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1223 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1281
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1282 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1339
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1398
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1399 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1458
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1459 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1516
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVA 1602
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1265 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1319
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1320 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1374
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1375 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1435 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1545 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1596
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1597 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1655
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1656 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1715
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1716 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1775
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1776 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1831
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1832 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1891
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2012 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2070
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2071 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2126
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2226
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1699 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1745
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1804
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1805 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1864 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1920
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1921 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2096
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2097 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2152
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2153 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2193
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2194 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2373
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2374 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2418
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2419 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2461
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2462 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2518
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2519 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2568
Query: 1230 LE 1231
LE
Sbjct: 2569 LE 2570
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1765 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1824
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1825 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1877
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1878 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1925
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 1986 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2043 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2161
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2162 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2215
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2216 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2266
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2267 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2324
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2325 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2383
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2502
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2503 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2599
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1057 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1096
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1097 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1150
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1151 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1202
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1203 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1252
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1253 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1307 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1361
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1362 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1418
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1419 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1478
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1479 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1536
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1596
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1597 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1644
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1645 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1700
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1701 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1751
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1752 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAE 1955
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 955 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1014
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1015 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1074
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1130
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1131 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1190
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1191 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1249
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1250 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1307
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1366
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1367 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1426
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1427 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1484
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVA 1570
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1434 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1488
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1489 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1543
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1544 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1604 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1714 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1765
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1766 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1824
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1825 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1945 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 2000
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2181 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2295
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2395
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1868 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1914
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1973
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1974 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 2033 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2265
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2266 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2321
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2322 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2362
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2363 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2542
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2543 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2587
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2588 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2630
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2687
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2688 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2737
Query: 1230 LE 1231
LE
Sbjct: 2738 LE 2739
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1993
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1994 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 2046
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 2047 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 2094
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2155 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2212 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2331 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2385 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2435
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2436 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2493
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2494 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2552
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2671
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2672 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2731
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2732 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2768
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1226 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1265
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1266 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1319
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1320 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1371
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1372 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1421
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1422 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1476 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1531 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1648 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1705
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1765
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1766 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1813
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1814 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1869
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1870 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1920
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1921 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAE 2124
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 1124 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1183
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1184 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1243
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1299
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1300 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1359
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1360 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1418
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1419 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1476
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1535
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1536 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1595
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1653
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVA 1739
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1275 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1329
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1330 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1384
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1385 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1445 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1494
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1555 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1606
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1607 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1665
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1666 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1786 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1841
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2022 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2136
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2236
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1709 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1755
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1814
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1815 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1874 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2106
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2107 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2162
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2163 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2203
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2204 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2383
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2384 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2428
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2429 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2471
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2528
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2529 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2578
Query: 1230 LE 1231
LE
Sbjct: 2579 LE 2580
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1834
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1835 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1887
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1888 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1935
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 1996 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2053 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2172 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2225
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2226 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2276
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2277 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2334
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2335 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2393
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2512
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2513 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2572
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2573 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2609
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1067 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1106
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1107 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1160
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1161 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1212
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1213 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1262
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1263 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1317 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1372 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1489 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1546
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1606
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1607 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1654
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1655 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1710
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1711 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1761
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1762 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAE 1965
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 965 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1024
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1025 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1084
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1140
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1259
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1260 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1317
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1376
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1494
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1495 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVA 1580
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1283 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1337
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1338 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1392
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1393 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1453 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1502
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1563 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1614
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1615 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1673
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1674 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1733
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1734 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1793
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1794 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1849
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1850 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1909
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 1970 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2029
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2030 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2088
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2089 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2144
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2244
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1717 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1763
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1822
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1823 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1882 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1938
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1939 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 1999 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2058
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2114
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2115 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2170
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2171 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2211
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2212 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2391
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2392 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2436
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2437 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2479
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2480 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2536
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2537 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2586
Query: 1230 LE 1231
LE
Sbjct: 2587 LE 2588
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1783 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1842
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1843 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1895
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1896 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1943
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2004 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2061 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2179
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2180 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2233
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2234 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2284
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2285 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2342
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2343 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2401
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2402 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2461
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2462 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2520
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2521 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2580
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2581 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2617
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1075 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1114
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1115 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1168
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1169 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1220
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1221 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1270
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1271 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1325 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1379
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1380 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1436
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1437 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1496
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1497 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1554
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1614
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1615 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1662
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1663 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1718
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1719 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1769
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1770 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAE 1973
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 973 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1032
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1033 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1092
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1148
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1149 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1208
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1209 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1267
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1268 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1325
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1326 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1384
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1385 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1444
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1445 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1502
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1503 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVA 1588
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 170 bits (430), Expect = 1e-41
Identities = 237/1000 (23%), Positives = 436/1000 (43%), Gaps = 92/1000 (9%)
Query: 305 ASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHI 364
AS + P S S S + V R + L T TS +Y + IS T E E+++
Sbjct: 1324 ASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLTS-QYIKFISETLRRME---EEERLA 1378
Query: 365 EQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREK 424
EQ AE AEV A ++ + A A+ ++ EL+ +M + E RE+
Sbjct: 1379 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE-----EVVRREE 1433
Query: 425 VELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELR 484
+ Q ++ + E Q R E+ + A +E+SR+ E+ +R+Q A R
Sbjct: 1434 AAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493
Query: 485 RRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHF---GAREETHQKE 541
+R G + L Q + + E+ E + Q E L+ R+ + E
Sbjct: 1494 QR-------GGAEGEL---QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1543
Query: 542 IKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSK 601
+ + A + ++E + LE + + + Q A+E + S
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603
Query: 602 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 661
L ++ A FAE Q+E+ L +H + Q ++++ER A ++ EA RA+ +E E
Sbjct: 1604 ELQSKRASFAEKTAQLERS-LQEEH-VAVAQLREEAERRAQ-QQAEAERAR-----EEAE 1655
Query: 662 NSLEAIRSKLDKAEDQHLVEMEDTLNK-LQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL 720
LE + K ++A L E K L +AE + K+ E + + + K + Q
Sbjct: 1656 RELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREARRRGKAEEQAVRQR 1714
Query: 721 KATEEKLLDLDALRKASSE----GKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSIT 776
+ E++L L + +++ + E+ +LR + E E+Q + LE E +A++ T
Sbjct: 1715 ELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1774
Query: 777 RELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK-----------FAEASEEAVSVQ 825
++ Q E +L ++ + + K E+E + EK F E +EEA ++
Sbjct: 1775 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1834
Query: 826 RSMQETVNKLHQKEEQFNMLSSDLEK-LRENLADMEAKFREKDEREEQLIKAKEKLENDI 884
+E + EE ++ E+ L E LA + R K E E I KEK E +
Sbjct: 1835 ALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---IALKEK-EAEN 1890
Query: 885 AEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQ 944
+ +++ D + Q ++ ++ + D+EE +L KA+++ QK + + T++ +
Sbjct: 1891 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1950
Query: 945 QE-------AAKKHEEEKKELERKLSDLEKKMET---SHNQCQELKARYERATSETKTKH 994
+E + +K K ELE +L + E S Q + AR + +E + +
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010
Query: 995 EEILQNLQKTLLDTED---KLKGAREENSGLLQELEELRK-----QADKAKAAQTAEDAM 1046
E + +QK+L E+ + K A EE L ++EE R+ + + A+ Q A++A
Sbjct: 2011 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2070
Query: 1047 QIMEQMTKEKTETLASLEDTKQTNAKLQNE---LDTLK---ENNLKNVEELNKSKELLTV 1100
Q Q +EK A + ++ LQ E LD L+ E + EE +++
Sbjct: 2071 QKRLQ-AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2129
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
E + +E E LKQ+A +++Q + Q AE+L + ++ + + E+ ++
Sbjct: 2130 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAA----AEKLRKEAEQEAARRAQAEQAALR 2185
Query: 1161 NNQLLEMK-KRESKFIKDADEEKASLQKSISITSALLTEK-------DAELEKLRNEVT- 1211
Q + + ++ KF + +KA +++ ++ L E D EL++L+ E T
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245
Query: 1212 VLRGENASAKSLHSV-VQTLESDKVKLELKVKNLELQLKE 1250
R + + L SV VQ E K+K ++ +N L L++
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRD 2285
Score = 142 bits (359), Expect = 2e-33
Identities = 221/962 (22%), Positives = 414/962 (43%), Gaps = 155/962 (16%)
Query: 335 LLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELAL 394
LL E +R R+ + T +K+Q +E LA+ RAE+ + E+E
Sbjct: 1758 LLEEELARLQREAAAAT-------QKRQELEAELAK---VRAEMEVLLASKARAEEE--- 1804
Query: 395 ARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGD 454
+R ++ LEA+ + R + E A R + L + + +++ E+ R E+
Sbjct: 1805 SRSTSEKSKQRLEAEAGRFRELAEEAARLRA-LAEEAKRQRQLAEEDAARQRAEAERVLA 1863
Query: 455 LEVATVSEKSRIMELEKDLALRVQEVAELR-RRLESNKPAGDVDMSLSLLQEISSLQEKL 513
++A + E +R+ + E ++AL+ +E R RRL ++ + Q + ++E+L
Sbjct: 1864 EKLAAIGEATRL-KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922
Query: 514 EVTRTDHQREITSLKEHFGAREETH------QKEIKALYTATEKLSKENESLKSKLEHAN 567
R E+ K G E+T ++EI AL + EK + L+ +L
Sbjct: 1923 AQLRKASDSELERQK---GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIR 1979
Query: 568 KENSDVI-ALWKSKLETA-----IASHQQAMEELKVSFSKGLGTETA----------EFA 611
D + + +++LE A A ++ E + K L E E
Sbjct: 1980 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 612 ELKTQIEKMRL-----------DYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEK 660
LK ++E+ R Q E Q + +E AHA ++ +L + ++++
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099
Query: 661 ENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA---EIKVKELEVLQAKCNEQTKVIDNFT 717
++ L+ +R + + A E + +EA +V+E E L+ EQ +
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQA----R 2155
Query: 718 SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
+Q +A EKL +A ++A+ ++E LRQ+ A + KH + + KA
Sbjct: 2156 AQAQAAAEKLRK-EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV--- 2211
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
E +LT L+ L E K L++ELQ LK + EA+ QRS Q
Sbjct: 2212 -----EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR-----QRS---------Q 2252
Query: 838 KEEQFNMLSSDLEKLRENLADMEAK-----FREKDEREEQLIKAKEKLENDIAEIMKMS- 891
EE+ + +E+L + A +EA+ R+KD + L + EK++ E ++S
Sbjct: 2253 VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 892 -GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKK 950
+++L ++ +E ++R + E LK + K+ ++ + ++ QE A++
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 951 HEEEKKELERKLSD----LEKKMETSHNQCQELKARYERAT------SETKTKHEEILQN 1000
+E+K+++ ++L++ ++ +E + E+ A ER S + + EE Q
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQR 2432
Query: 1001 LQKTLLDTEDKLKG---AREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKT 1057
+K + +KL A +E L+Q LE R+Q+D DA ++ E
Sbjct: 2433 FRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD--------HDAERLRE------- 2477
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
+A LE K+ KLQ E L+ KS+E+ TV+ E+ +E + L+Q
Sbjct: 2478 -AIAELEREKE---KLQQEAKLLQL----------KSEEMQTVQQ---EQLLQETQALQQ 2520
Query: 1118 AAAQKSQQLSA----LQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESK 1173
+ + L +++E KL + +DEV Q+L EE+ Q+ + ++R
Sbjct: 2521 SFLSEKDSLLQRERFIEQEKAKLEQLF---QDEVAKAQQLREEQQRQQQQMEQERQRLVA 2577
Query: 1174 FIKDADEEKASLQKSISITSALLTEKDAELEKL----RNEVTVLRGENASAKSLHSVVQT 1229
+++A + ++ + K EL++L R + +L EN + L +Q
Sbjct: 2578 SMEEARRRQHEAEEGV-------RRKQEELQQLEQQRRQQEELLAEEN---QRLREQLQL 2627
Query: 1230 LE 1231
LE
Sbjct: 2628 LE 2629
Score = 138 bits (348), Expect = 3e-32
Identities = 186/880 (21%), Positives = 373/880 (42%), Gaps = 77/880 (8%)
Query: 298 RVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEAL 357
R +A +A L+ + + + R +L E + T + AL
Sbjct: 1824 RELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIAL 1883
Query: 358 KEKQQHIEQL--LAERDL--ERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQL 413
KEK+ E+L LAE + R +A H +IE+ LA R D +++++
Sbjct: 1884 KEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD-------SELERQ 1936
Query: 414 RTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDL 473
+ +VE R++ Q+EEE + L+ E+ + K +LE+ E RI +D
Sbjct: 1937 KGLVEDTLRQR----RQVEEE---ILALKASFEKAAAGKAELEL----ELGRIRSNAED- 1984
Query: 474 ALRVQEVAELRRRLESNKPAGDVDMSLSL---LQEISSLQEKLEVTRTDHQREITSLKEH 530
LR +E AEL + A + +Q+ + +E+ R E+ LK
Sbjct: 1985 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2044
Query: 531 FGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQ 590
EE + +A + +L E+ + +L+ K ++ + + +L+ + Q
Sbjct: 2045 V---EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 591 AMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQN-QQDSERAAHAKEMEAL 649
+++L+ ++ E E + Q E+ + ++E + +Q +E A A+
Sbjct: 2102 VLDQLRGE-AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 650 RAKLMKVIKEKENSLEA------IRSK--LDKAEDQHLVEMEDTLNKLQEAEIKVKELEV 701
A+ ++ E+E + A +R K D ++H E TL + + E ++ L +
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2220
Query: 702 LQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL 761
+ + Q ++D +LKA + + S+ + E+ +R Q+E K +
Sbjct: 2221 QLEETDHQKNLLDEELQRLKA------EATEAARQRSQVEEELFSVRVQMEELSKLKARI 2274
Query: 762 EIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKE--KFAEASE 819
E E A + T+ LQE ++ QV E + +E + + +E
Sbjct: 2275 EAENRALILRDKDNTQRF---------LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAE 2325
Query: 820 EAVSVQRSMQETVNKLH-QKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKE 878
E ++ QR++ E + K Q ++ L ++ E L++ + + R E +EQ+ A++
Sbjct: 2326 EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM--AQQ 2383
Query: 879 KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTV 938
E + + QL + RLK R V E+ +A E+A +K E++
Sbjct: 2384 LAEETQGFQRTLEAERQRQLEMSAEAERLKLR-VAEMSRAQARAEEDAQRFRKQAEEIGE 2442
Query: 939 KAEQSQQEAAKK-------------HEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
K +++ +K + + + L +++LE++ E + + L+ + E
Sbjct: 2443 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2502
Query: 986 ATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDA 1045
+ + + + Q LQ++ L +D L +LE+L Q + AKA Q E+
Sbjct: 2503 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF-QDEVAKAQQLREEQ 2561
Query: 1046 MQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKM 1105
+ +QM +E+ +AS+E+ ++ + + + +E + ++ + +ELL ENQ++
Sbjct: 2562 QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2621
Query: 1106 EEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRD 1145
E + +E +AA S++++A Q V + L RD
Sbjct: 2622 REQLQLLEEQHRAALAHSEEVTASQ---VAATKTLPNGRD 2658
Score = 121 bits (303), Expect = 5e-27
Identities = 219/1047 (20%), Positives = 434/1047 (41%), Gaps = 147/1047 (14%)
Query: 289 AKAKANAVRRVMATTSASLKR-------SPSASSL-SSMSSVASSVSSRPSRTGLLTETS 340
A+A+ + + +A SA ++ SP+A +L S + + S + + E
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115
Query: 341 SRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHD 400
+ I GT +E L+ E L+ A+ AT + E+E
Sbjct: 1116 KTISLVIRGTQGAEEVLRAH---------EEQLKEAQAVPAT--LPELEAT--------- 1155
Query: 401 QHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESIT--KGDLEVA 458
+A + +LR EA L ++L + E LQ R E + + VA
Sbjct: 1156 ------KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVA 1209
Query: 459 TVSEKSRIMELEKDLALRVQEVAELRRRL----ESNKPAGDVDMSLSLLQEISSLQEKLE 514
+ E+ + + + D+ R +E+ +L R+L ES P G + LQ+ QE+++
Sbjct: 1210 QLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADPLG------AWLQDARRRQEQIQ 1261
Query: 515 VTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEKLSKENESLKSKLEHANKENSD 572
L + RE+ Q++ ++ + EK+ +E + + +A K+
Sbjct: 1262 AM---------PLADSQAVREQLRQEQALLEEIERHGEKV-EECQRFAKQYINAIKDYEL 1311
Query: 573 VIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEI---- 628
+ +K++LE A K G + E+ +L+T ++ I
Sbjct: 1312 QLVTYKAQLEPV------ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 629 ENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLD---KAEDQHLVEMEDT 685
E L+ ++ ER A E RA+ + + E E +LE R + +A+ Q E ++
Sbjct: 1366 ETLRRMEEEERLA-----EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1420
Query: 686 LNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEG----- 740
++QE ++ +E V +Q + I QL+ + E + A + ++E
Sbjct: 1421 QQRMQEEVVRREEAAV---DAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1477
Query: 741 KSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVK 800
+ E++ +R QLEA E+Q E E A ++A + + + + L+ + + SQ K
Sbjct: 1478 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1537
Query: 801 ETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRE------ 854
E EL + AEA+ E ++++E +L +E + + +++E+ R+
Sbjct: 1538 RQAEVELASRVKAEAEAAREKQRALQALEEL--RLQAEEAERRLRQAEVERARQVQVALE 1595
Query: 855 -----NLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKE 909
A++++K E+ QL ++ ++ +A++ + + + Q + E
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAE 1655
Query: 910 RDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKM 969
R++E QL KANE A L+ E++ + +Q EA K+ EE ++E R+
Sbjct: 1656 RELERWQL---KANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR-------- 1703
Query: 970 ETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL 1029
+ +E R + K ++ + + L E +L R E Q+ + L
Sbjct: 1704 ----GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1759
Query: 1030 RKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE 1089
++ A+ + A A Q +++ E + A +E + A+ + E + E
Sbjct: 1760 EEEL--ARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE------- 1810
Query: 1090 ELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVK--------LAEEL- 1140
KSK+ L E + E +E L+ A + +Q +E+ + LAE+L
Sbjct: 1811 ---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 1141 --GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTE 1198
G + T + +E+ N +L + + E+ + +E+ A + I A L +
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 1199 -KDAELEKLRNEV-TVLRGENASAKSLHSVVQTLE---SDKVKLELKV----KNLELQLK 1249
D+ELE+ + V LR + + ++ + E + K +LEL++ N E L+
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQ 1276
++ ++ A+E+ R +E++
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAE 2014
Score = 74.7 bits (182), Expect = 6e-13
Identities = 126/626 (20%), Positives = 244/626 (38%), Gaps = 105/626 (16%)
Query: 742 SEMKKLRQQLEAAEKQIKH---LEIEKN---------AESSKASSITRELQGRELKLTNL 789
SE+K +R QLEA E + H L ++K AE KA + L +L+
Sbjct: 1014 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1073
Query: 790 QEN---LSEVSQVKETLEKELQI----------LKEKFAEASEEAVSVQRSMQETVNKLH 836
E L E S TL EL++ L + E + V R Q L
Sbjct: 1074 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1133
Query: 837 QKEEQFNMLSS------DLEKLRENL----ADMEAKFREKDEREEQLIKAKEKLENDIAE 886
EEQ + +LE + +L A EA+ D ++L A+E E
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE----R 1189
Query: 887 IMKMSGDNSSQLTKMNDELR--------------LKERDVEELQLKLTKANENASFLQKS 932
+ + G+ ++ + + + +++R++E+L +L E+A L
Sbjct: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249
Query: 933 IEDMTVKAEQSQQEAAKKHEEEKKELERK---LSDLEKKMETSHNQCQELKARYERATSE 989
++D + EQ Q + +++L ++ L ++E+ E +CQ +Y A +
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE-KVEECQRFAKQYINAIKD 1308
Query: 990 TKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADK------------AK 1037
+ + + Q + + K + + ++QE +LR + ++
Sbjct: 1309 YEL--QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISE 1366
Query: 1038 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQ---------TNAKLQNELDTLKENNLKNV 1088
+ E+ ++ EQ E+ E LA +E + AK Q E + KE +
Sbjct: 1367 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA-KELQQRMQ 1425
Query: 1089 EELNKSKELLTVENQKMEEFRKEIETLKQAA----AQKSQQLSALQEENVKLAEEL---- 1140
EE+ + +E Q+ ++E++ L+Q++ K++Q A + +++ EE+
Sbjct: 1426 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1485
Query: 1141 ----------GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSIS 1190
G + E+ + + EE Q E +R + ++D + K Q +
Sbjct: 1486 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR--QAEVE 1543
Query: 1191 ITSALLTEKDAELEKLRN----EVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLEL 1246
+ S + E +A EK R E L+ E A + + V+ +V LE ++ E
Sbjct: 1544 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603
Query: 1247 QLKENKRQLSSSSGNTDTQADEDERA 1272
+L+ + + + + E+ A
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVA 1629
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 170 bits (430), Expect = 1e-41
Identities = 223/1002 (22%), Positives = 436/1002 (43%), Gaps = 132/1002 (13%)
Query: 295 AVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQ 354
A RR + LK+ L+ ++ + ++ LTE + ++ T +
Sbjct: 987 ARRRKLEDECTELKKDIDDLKLT-LAKAEKEKQATENKVKNLTEEMAALDESVARLTKEK 1045
Query: 355 EALKEK-QQHIEQLLAERDLERAEVAKATSHVGE--------IEQELALARDGHDQHVLE 405
+AL+E QQ + L AE D A + KA + + +EQE L D ++ +
Sbjct: 1046 KALQEAHQQALGDLQAEEDRVSA-LTKAKLRLEQQVEDLECSLEQEKKLRMDT-ERAKRK 1103
Query: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
LE + + V A ++K +L +L+++ ++ L RVE+E + ++ ++R
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR 1163
Query: 466 IMELEKDL--------------ALRVQEVAELRRRLE--SNKPAGDVDMSLSLLQEISSL 509
ELE++L A +E+ EL RLE AG + E+ L
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223
Query: 510 QEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKE 569
+ +LE H+ + +L+ +++ +L +KL KE L+ +++
Sbjct: 1224 RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDL-AA 1282
Query: 570 NSDVIALWKSKLETAIASHQQAMEELKV------------SFSKG-LGTETAEFA----- 611
N + + K+ E +++ + E K+ S +G L TE+ E +
Sbjct: 1283 NVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEE 1342
Query: 612 --------------------ELKTQIE---KMRLDYQHEIENLQNQQDSERAAHAKEMEA 648
EL+ Q+E K + H ++ L++ D R H +E EA
Sbjct: 1343 KECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEA 1402
Query: 649 LRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK----LQEAEIKVKELEVLQA 704
+A+L +++ + + RSK + Q E+E+ K LQEAE + +E A
Sbjct: 1403 -QAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAE---EGVEAANA 1458
Query: 705 KCNEQTKV-------IDNFTSQLKATEEKLLDLDA----LRKASSEGKSEMKKLRQQLEA 753
KC+ K ++ T +L+ LD L +A E + + ++++++LEA
Sbjct: 1459 KCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQRELEA 1518
Query: 754 AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEK 813
A+++ + L E L+ + + NLQE +S+++ K +Q L++
Sbjct: 1519 AQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKT 1578
Query: 814 FAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 873
E +Q +++E L +E + + +L +++ A+++ K EKDE L
Sbjct: 1579 KKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVK---AEVDRKLAEKDEECANL 1635
Query: 874 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKLTKANENASFLQ 930
+ N + + ++ N+ LRLK E D+ +L+L+L A A+ Q
Sbjct: 1636 RR------NHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQ 1689
Query: 931 KSIEDMTVKAEQSQQEAAKKHEEEK--KELERKLSDLEKKMETSHNQCQELKARYERATS 988
+ M Q ++E A + EE++ EL + LE++ + +EL+A E+
Sbjct: 1690 AATRLMQA---QLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEELRAALEQGER 1746
Query: 989 ETKTKHEEILQNLQKT---------LLDTEDKLKGAREENSGLLQELEELRKQADKAKAA 1039
+ +E+L+ ++ LL+ + KL+ + SG ++E + R++A++ KA
Sbjct: 1747 SRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEE-KAK 1805
Query: 1040 QTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKENNL----KNVEEL 1091
+ DA + E++ KE+ +T A LE K QT +LQ L+ ++ L K V++L
Sbjct: 1806 KAITDAAMMAEELKKEQ-DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKL 1864
Query: 1092 N-KSKEL---LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEV 1147
K +EL L E +K E K + ++ + + Q ++ ++ + + + + +V
Sbjct: 1865 EAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKNLARMQDLVDKLQSKV 1924
Query: 1148 TSHQK-LEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
S+++ EE N L + +K + + D EE+A + ++
Sbjct: 1925 KSYKRQFEEAEQQANTNLAKYRKAQHEL--DDAEERADMAET 1964
Score = 159 bits (402), Expect = 2e-38
Identities = 216/1029 (20%), Positives = 436/1029 (42%), Gaps = 112/1029 (10%)
Query: 356 ALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRT 415
AL+ + + + LA + +R E+ + + + + +LAL ++ + E + L
Sbjct: 900 ALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAEERCHLLIK 959
Query: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLAL 475
+ + EL +LE+E+ DL R + LE K I +L+ LA
Sbjct: 960 SKVQLEGKVKELSERLEDEEEVNADLAAR-------RRKLEDECTELKKDIDDLKLTLA- 1011
Query: 476 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 535
AE ++ NK + +L + ++ L ++ + + HQ+ + L
Sbjct: 1012 ----KAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDL-------- 1059
Query: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV----------IALWKSKLETAI 585
+ + + AL A +L ++ E L+ LE K D + L + + A
Sbjct: 1060 QAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQESVADAA 1119
Query: 586 ASHQQAMEELKVSFSK--GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA 643
QQ E+LK S+ L + L Q++K + Q E L+ + ++ERAA
Sbjct: 1120 QDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEAERAA-- 1177
Query: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
RA++ K E LE + +L++A + E + +EAE+ E+ +
Sbjct: 1178 ------RARVEKQRAEAARELEELSERLEEAGGASAGQREGC--RKREAELGRLRRELEE 1229
Query: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
A + V Q + E +D+L++ + + E +LR +++ ++ L
Sbjct: 1230 AALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETLTR 1289
Query: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE----LQILKEK---FAE 816
K + + +L ++K+ LQ L++ S + L+ E ++L+EK ++
Sbjct: 1290 AKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKECLISQ 1349
Query: 817 ASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 876
S +S++E +L ++ + + L+ ++ LR + + + E+ E + +L +
Sbjct: 1350 LSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRL 1409
Query: 877 KEKLENDIAEIMKMSGDNSSQLTKMNDE------LRLKERD--VEELQLKLTKANENASF 928
K ++A+ ++ Q T+ +E LRL+E + VE K + +
Sbjct: 1410 LSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLR 1469
Query: 929 LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATS 988
LQ ED+T++ E++ AA L++K LE+ +E Q +E++ E A
Sbjct: 1470 LQTESEDVTLELERATSAAA--------ALDKKQRHLERALEERRRQEEEMQRELEAAQR 1521
Query: 989 ETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQAD-KAKAAQTAEDAMQ 1047
E++ E+ + L+ + + L+ + EN L +E+ +L Q K+ Q E +
Sbjct: 1522 ESRGLGTELFR-LRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKK 1580
Query: 1048 IME------QMTKEKTETLASLEDTKQTNAKLQ----------------NELDTLKENNL 1085
+E Q E+ E LE+TK +L+ E L+ N+
Sbjct: 1581 ALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQ 1640
Query: 1086 KNVEELNKSKELLTVENQKMEEFRKEIE--------TLKQAAAQKSQQLSALQEENVKLA 1137
+ VE L S + T + +K++E L A Q ++ +A + +L
Sbjct: 1641 RAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQATEAQAATRLMQAQLK 1700
Query: 1138 EELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
EE RDE Q+L E L+ Q +++R S + +E +A+L++ S L
Sbjct: 1701 EEQA-GRDE---EQRLAAE---LHEQAQALERRASLLAAELEELRAALEQ--GERSRRLA 1751
Query: 1198 EKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSS 1257
E+ EL + + +L +N L + + LE+D +L +V+ + +E + +
Sbjct: 1752 EQ--ELLEATERLNLLHSQNT---GLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKK 1806
Query: 1258 SSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYD 1317
+ + A+E ++ Q++ L + L++ ++L+ ++E +AAL G + +
Sbjct: 1807 AITDAAMMAEELKKEQDTSA-HLERMKKTLEQTVRELQARLEEAEQAALRGGKKQVQKLE 1865
Query: 1318 SDDQEKQSK 1326
+ +E +++
Sbjct: 1866 AKVRELEAE 1874
Score = 99.8 bits (247), Expect = 2e-20
Identities = 137/600 (22%), Positives = 256/600 (42%), Gaps = 80/600 (13%)
Query: 714 DNFTSQLKATEEKL--LDLDALRKASSEGK--------SEMKKLRQQLEAAEKQIKHLEI 763
D F KATE+ L LDLD + K +++LR Q A K + L+
Sbjct: 782 DTFMDSRKATEKLLGSLDLDHTQYQFGHTKVFFKAGLLGVLEELRDQRLA--KVLTLLQA 839
Query: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKE-----------------TLEKE 806
+ R L GR+ T +Q N+ + VK E+E
Sbjct: 840 RSRGRLMRLE-YQRLLGGRDALFT-IQWNIRAFNAVKNWSWMKLFFKMKPLLRSAQAEEE 897
Query: 807 LQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREK 866
L L+ + + + QE ++ N L+ L+ ++NLAD E
Sbjct: 898 LAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQAEQDNLADAE------ 951
Query: 867 DEREEQLIKAKEKLENDIAEIMK-------MSGDNSSQLTKMNDELRLKERDVEELQLKL 919
ER LIK+K +LE + E+ + ++ D +++ K+ DE ++D+++L+L L
Sbjct: 952 -ERCHLLIKSKVQLEGKVKELSERLEDEEEVNADLAARRRKLEDECTELKKDIDDLKLTL 1010
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQC-QE 978
KA + + ++++T + + A+ +E +K ++ +H Q +
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKE------------KKALQEAHQQALGD 1058
Query: 979 LKARYERATSETKTK--HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKA 1036
L+A +R ++ TK K E+ +++L+ + L+ E KL+ E L+ +L +++
Sbjct: 1059 LQAEEDRVSALTKAKLRLEQQVEDLECS-LEQEKKLRMDTERAKRKLEGDLKLTQES--- 1114
Query: 1037 KAAQTAEDAMQIMEQMTK---EKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNK 1093
A A+D Q+ E++ K E ++ +ED + A++Q ++ L+ + EEL
Sbjct: 1115 -VADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEELEEELEA 1173
Query: 1094 SKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKL 1153
+ ++ E +E+E L + + + +E K ELGR R E L
Sbjct: 1174 ERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLRRE------L 1227
Query: 1154 EEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVL 1213
EE + +++++++ + E+ SLQ+ +E E++ L V L
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANVETL 1287
Query: 1214 RGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ---LSSSSGNTDTQADEDE 1270
ASA+ L +T E + ++KV+ L+ QL + Q L + SG +E E
Sbjct: 1288 TRAKASAEKL---CRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 169 bits (429), Expect = 1e-41
Identities = 228/1013 (22%), Positives = 460/1013 (45%), Gaps = 146/1013 (14%)
Query: 291 AKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGT 350
A+ A +R + + LKR L+ ++ V + ++ LTE + I+
Sbjct: 934 AELTAKKRKLEDECSELKRDIDDLELT-LAKVEKEKHATENKVKNLTEEMAGLDEIIAKL 992
Query: 351 TALQEALKEK-QQHIEQLLAERD----LERAEVA---KATSHVGEIEQELALARDGH--- 399
T ++AL+E QQ ++ L AE D L +A+V + G +EQE + D
Sbjct: 993 TKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1052
Query: 400 ----------DQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEK-------RKVEDLQ 442
+ +++LE QL ++ D E L ++E+E+ +K+++LQ
Sbjct: 1053 RKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
Query: 443 FRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSL 502
R+EE + +LE A + ++++ +L DL+ +E+ E+ RLE A V + ++
Sbjct: 1113 ARIEE---LEEELE-AERTARAKVEKLRSDLS---RELEEISERLEEAGGATSVQIEMNK 1165
Query: 503 LQ--EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLK 560
+ E ++ LE H+ +L++ ++I L +KL KE K
Sbjct: 1166 KREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK 1225
Query: 561 SKLEHANKENSDVIALWKS------KLETAIASHQQAMEELKVSFS------KGLGTETA 608
+L+ +I + LE + H+ EE + S + L TE
Sbjct: 1226 LELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG 1285
Query: 609 EFAE-------LKTQIEKMRLDYQHEIENLQNQQDSE---------------------RA 640
E + L +Q+ + +L Y ++E+L+ Q + E R
Sbjct: 1286 ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLRE 1345
Query: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNK----LQEAEIKV 696
+ +E EA +A+L +V+ + + + R+K + Q E+E+ K LQEAE
Sbjct: 1346 QYEEETEA-KAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE--- 1401
Query: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS--------------SEGKS 742
+ +E + AKC+ K +++ E+ ++D++ A+ +E K
Sbjct: 1402 EAVEAVNAKCSSLEKTKHRLQNEI---EDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1458
Query: 743 EMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKET 802
+ ++ + +LE+++K+ + L E + L+ + + NLQE +S++++ +
Sbjct: 1459 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGS 1518
Query: 803 LEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAK 862
K + L++ + E + +Q +++E L + E+ +L + LE + A++E K
Sbjct: 1519 SGKTIHELEKVRKQLEAEKMELQSALEEAEASL--EHEEGKILRAQLE-FNQIKAEIERK 1575
Query: 863 FREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK---ERDVEELQLKL 919
EKDE EQ AK N + + + ++ N+ LR+K E D+ E++++L
Sbjct: 1576 LAEKDEEMEQ---AK---RNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629
Query: 920 TKANENASFLQKSIEDM--TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
+ AN A+ QK ++ + +K Q Q + A + ++ KE ++ +E++ + +
Sbjct: 1630 SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKE---NIAIVERRNNLLQAELE 1686
Query: 978 ELKARYERATSETKTKHEEILQNLQK---------TLLDTEDKLKGAREENSGLLQE-LE 1027
EL+A E+ K +E+++ ++ +L++ + K+ + ++E ++
Sbjct: 1687 ELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQ 1746
Query: 1028 ELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTK----QTNAKLQNELDTLKEN 1083
E R +KAK A T DA + E++ KE+ +T A LE K QT LQ+ LD ++
Sbjct: 1747 ECRNAEEKAKKAIT--DAAMMAEELKKEQ-DTSAHLERMKKNMEQTIKDLQHRLDEAEQI 1803
Query: 1084 NLK-NVEELNK-SKELLTVENQKMEEFRKEIETLK--QAAAQKSQQLSALQEEN----VK 1135
LK ++L K + +EN+ E ++ E++K + + ++ ++L+ EE+ ++
Sbjct: 1804 ALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLR 1863
Query: 1136 LAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKS 1188
L + + + + +V ++++ EE N L K R+ + D EE+A + +S
Sbjct: 1864 LQDLVDKLQLKVKAYKRQAEEAEEQANTNLS-KFRKVQHELDEAEERADIAES 1915
Score = 156 bits (394), Expect = 1e-37
Identities = 212/1038 (20%), Positives = 449/1038 (43%), Gaps = 130/1038 (12%)
Query: 356 ALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRT 415
++KE+ +++ L + + R E+ + + + + +L L ++ + E + DQL
Sbjct: 851 SMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910
Query: 416 MVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLAL 475
+ + E+ +LE+E+ +L + K LE K I +LE LA
Sbjct: 911 NKIQLEAKVKEMNERLEDEEEMNAEL-------TAKKRKLEDECSELKRDIDDLELTLA- 962
Query: 476 RVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGARE 535
E + NK + L + I+ L ++ + + HQ+ + L
Sbjct: 963 ----KVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDL-------- 1010
Query: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595
+ + ++ L A KL ++ + L+ LE K D + K KLE + Q+++ +L
Sbjct: 1011 QAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD-LERAKRKLEGDLKLTQESIMDL 1069
Query: 596 ------------KVSFS-KGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAH 642
K F L + L +Q++K + Q IE L+ + ++ER A
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTAR 1129
Query: 643 AKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVL 702
AK +E LR+ L + LE I +L++A V++E +NK +EAE + ++
Sbjct: 1130 AK-VEKLRSDLSR-------ELEEISERLEEAGGATSVQIE--MNKKREAEFQKMRRDLE 1179
Query: 703 QAKCNEQTKVI---DNFTSQLKATEEKLLDLDALRKASSEGKSEMK--------KLRQQL 751
+A + + E++ +L +++ + KSE K + Q +
Sbjct: 1180 EATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQII 1239
Query: 752 EA---AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQ 808
+A EK + LE + N SKA R + + LQ E+S ++ EKE
Sbjct: 1240 KAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS--RQLDEKEAL 1297
Query: 809 ILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDE 868
I ++ + ++ + +++ +L ++ + N L+ L+ R + + ++ E+ E
Sbjct: 1298 I-----SQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETE 1352
Query: 869 REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ERDVEELQLKLT 920
+ +L + K +++A+ ++ Q T+ +E + K E VE + K +
Sbjct: 1353 AKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCS 1412
Query: 921 KANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKK------ELERKLSDLEKKMETSHN 974
+ LQ IED+ V E+S AA ++++ E ++K + + ++E+S
Sbjct: 1413 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQK 1472
Query: 975 QCQ-------ELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELE 1027
+ + +LK YE + +T E +NLQ+ + D ++L + + + ELE
Sbjct: 1473 EARSLSTELFKLKNAYEESLEHLETFKRE-NKNLQEEISDLTEQLGSSGK----TIHELE 1527
Query: 1028 ELRKQ--ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ-------NELD 1078
++RKQ A+K + E+A +E E+ + L + + Q A+++ E++
Sbjct: 1528 KVRKQLEAEKMELQSALEEAEASLEH---EEGKILRAQLEFNQIKAEIERKLAEKDEEME 1584
Query: 1079 TLKENNLKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKS--QQLSALQEENVK 1135
K N+L+ V+ L S + T + +K++E L + Q S +++A ++ VK
Sbjct: 1585 QAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVK 1644
Query: 1136 LAEELGRSR-----DEVTSHQKLEEERSVL--NNQLLEMKKRESKFIKDADEEKASLQKS 1188
+ L + D V ++ L+E +++ N LL+ + E + + + E L
Sbjct: 1645 SLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKL--- 1701
Query: 1189 ISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQL 1248
+ EL + V +L +N SL + + +++D +L+ +V+ +
Sbjct: 1702 ----------AEQELIETSERVQLLHSQNT---SLINQKKKMDADLSQLQTEVEEAVQEC 1748
Query: 1249 KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNG 1308
+ + + + + A+E ++ Q++ L + ++++ +DL+ +++ + AL G
Sbjct: 1749 RNAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 1309 NGDDLNNYDSDDQEKQSK 1326
L ++ +E +++
Sbjct: 1808 GKKQLQKLEARVRELENE 1825
Score = 156 bits (394), Expect = 1e-37
Identities = 213/1019 (20%), Positives = 450/1019 (44%), Gaps = 133/1019 (13%)
Query: 359 EKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVE 418
EK++H + + E E+A + ++ +E ++ H Q + +L+A+ D++ T+ +
Sbjct: 965 EKEKHATENKVKNLTE--EMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTK 1022
Query: 419 AADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQ 478
A KV+L +++V+DL+ +E+E + DLE A +LE DL L +
Sbjct: 1023 A----KVKL-------EQQVDDLEGSLEQEKKVRMDLERAK-------RKLEGDLKLTQE 1064
Query: 479 EVAEL---RRRLESNKPAGDVDMSL--SLLQEISSLQEKLEVTRTDHQREITSLKEHFGA 533
+ +L +++L+ D +++ + +++ +L +L+ + Q I L+E A
Sbjct: 1065 SIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEA 1124
Query: 534 REETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSK----------LET 583
E T + +++ L + LS+E E + +LE A S I + K + LE
Sbjct: 1125 -ERTARAKVEKLRS---DLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180
Query: 584 AIASHQQAMEELKVSFSKG---LGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERA 640
A H+ L+ + LG + +K ++EK + +++ E++++ + +
Sbjct: 1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME---- 1236
Query: 641 AHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV-KEL 699
++ +A L K+ + E+ + RSK ++ + + + ++ KLQ ++ ++L
Sbjct: 1237 ----QIIKAKANLEKMCRTLEDQMNEHRSKAEETQ-RSVNDLTSQRAKLQTENGELSRQL 1291
Query: 700 EVLQAKCNEQTKVIDNFTSQL----KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAE 755
+ +A ++ T+ +T QL + EE++ +AL A + + LR+Q E
Sbjct: 1292 DEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEET 1351
Query: 756 KQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFA 815
+ + E SKA+S Q R T+ + E+ + K+ L + LQ +E
Sbjct: 1352 EA----KAELQRVLSKANS--EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVE 1405
Query: 816 EASEEAVSVQRS---MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQ 872
+ + S++++ +Q + L E+ N ++ L+K + N + A++++K E +
Sbjct: 1406 AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQS 1465
Query: 873 LIKAKEK----LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASF 928
+++ +K L ++ ++ ++ L E + + ++ +L +L + +
Sbjct: 1466 ELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHE 1525
Query: 929 LQK-----SIEDMTVKAEQSQQEAAKKHEEEK------------KELERKLSDLEKKMET 971
L+K E M +++ + EA+ +HEE K E+ERKL++ +++ME
Sbjct: 1526 LEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQ 1585
Query: 972 S-HNQCQELKARYERATSETKTKHE--EILQNLQKTLLDTEDKLKGARE---ENSGLLQE 1025
+ N + + + +ET++++E + + ++ L + E +L A E ++
Sbjct: 1586 AKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKS 1645
Query: 1026 LEELRKQA-----DKAKAAQTAEDAMQIMEQ----MTKEKTETLASLEDTKQTNAKLQNE 1076
L+ L K D +A ++ + I+E+ + E E A +E T+++ + E
Sbjct: 1646 LQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQE 1705
Query: 1077 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136
L E V+ L+ L + +KM+ +++T + A Q+ + EE K
Sbjct: 1706 LIETSER----VQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNA----EEKAKK 1757
Query: 1137 AEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEE------------KAS 1184
A D ++L++E+ + L MKK + IKD K
Sbjct: 1758 A-----ITDAAMMAEELKKEQDT-SAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQ 1811
Query: 1185 LQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNL 1244
LQK + L E +AE ++ V +R K L + + ++L+ V L
Sbjct: 1812 LQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKL 1871
Query: 1245 ELQLKENKRQLSSSSGNTDTQADEDERAQ------ESQIDFLNSVIVDLQRKNQDLKMK 1297
+L++K KRQ + +T + + Q E + D S + L+ K++D+ K
Sbjct: 1872 QLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Score = 152 bits (383), Expect = 3e-36
Identities = 209/930 (22%), Positives = 405/930 (43%), Gaps = 185/930 (19%)
Query: 468 ELEKDLALRVQEVAELRRRLESNKPAGDV--DMSLSLLQEISSLQEKLEVTRTDHQREIT 525
E EK++A +E L+ LE ++ + +SLLQE + D Q ++
Sbjct: 844 EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQE-----------KNDLQLQVQ 892
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAI 585
+ +++ EE + IK K+ + NE +LE + N+++ A K KLE
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNE----RLEDEEEMNAELTAK-KRKLEDEC 947
Query: 586 ASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKE 645
+ ++ +++L+++ +K +EK + +++++NL +E
Sbjct: 948 SELKRDIDDLELTLAK---------------VEKEKHATENKVKNL-----------TEE 981
Query: 646 MEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE-LEVLQA 704
M L + K+ KEK+ EA + LD + + ED +N L +A++K+++ ++ L+
Sbjct: 982 MAGLDEIIAKLTKEKKALQEAHQQALDDLQAE-----EDKVNTLTKAKVKLEQQVDDLEG 1036
Query: 705 KCNEQTKV-ID------NFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQ 757
++ KV +D LK T+E ++DL+ ++ ++L ++L+ + +
Sbjct: 1037 SLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLE----------NDKQQLDERLKKKDFE 1086
Query: 758 IKHLEIEKNAESSKASSITRELQGRELKLTNLQENL-------SEVSQVKETLEKELQIL 810
+ L E + S + ++L+ + ++ L+E L ++V +++ L +EL+ +
Sbjct: 1087 LNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEI 1146
Query: 811 KEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK-----------LRENLADM 859
E+ EA A SVQ M + ++E +F + DLE+ LR+ AD
Sbjct: 1147 SERLEEAGG-ATSVQIEMNK------KREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1199
Query: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
A E E+ + L + K+KLE + +E D +S + ++ E+ L+ ++
Sbjct: 1200 VA---ELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQM 1256
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAK--KHEEEKKEL-----------ERKLSDLE 966
+ A Q+S+ D+T + + Q E + + +EK+ L ++L DL+
Sbjct: 1257 NEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLK 1316
Query: 967 KKME--------------TSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKL 1012
+++E ++ + C L+ +YE T E K + + +L + K
Sbjct: 1317 RQLEEEVKAKNALAHALQSARHDCDLLREQYEEET-EAKAELQRVLSKANSEVAQWRTKY 1375
Query: 1013 KGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAK 1072
+ + +Q EEL + K K AQ ++A + +E + + +SLE TK +
Sbjct: 1376 E------TDAIQRTEELEEA--KKKLAQRLQEAEEAVEAVNAK----CSSLEKTKH---R 1420
Query: 1073 LQNELDTLK---ENNLKNVEELNKSK----ELLTVENQKMEEFRKEIET----------- 1114
LQNE++ L E + L+K + ++L QK EE + E+E+
Sbjct: 1421 LQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTE 1480
Query: 1115 ---LKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRE 1171
LK A + + L + EN L EE+ +++ S K E + QL K
Sbjct: 1481 LFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMEL 1540
Query: 1172 SKFIKDAD-----EEKASLQKSISIT------SALLTEKDAELEKL-RNEV-------TV 1212
+++A+ EE L+ + L EKD E+E+ RN + T
Sbjct: 1541 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTS 1600
Query: 1213 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG---NTDTQADED 1269
L E S V + +E D ++E+++ + E ++Q+ S +T Q D+
Sbjct: 1601 LDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDA 1660
Query: 1270 ERAQESQIDFLNSVIVDLQRKNQDLKMKVE 1299
RA D L I ++R+N L+ ++E
Sbjct: 1661 VRAN----DDLKENIAIVERRNNLLQAELE 1686
Score = 138 bits (348), Expect = 3e-32
Identities = 154/723 (21%), Positives = 320/723 (44%), Gaps = 83/723 (11%)
Query: 667 IRSKLDKAE-DQHLVEMEDTLNKLQEA----EIKVKELEVLQAKCNEQTKVIDNFTSQLK 721
I+ L AE ++ + M++ +L+EA E + KELE ++ ++ Q++
Sbjct: 836 IKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEK---NDLQLQVQ 892
Query: 722 ATEEKLLDL----DALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITR 777
A ++ L D D L K + ++++K++ ++LE E+ L +K + S + R
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKR 952
Query: 778 ELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
++ EL L +++ + L +E+ L E A+ ++E ++Q + Q+ ++ L
Sbjct: 953 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQA 1012
Query: 838 KEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQ 897
+E++ N L+ KL + + D+E ++ + L +AK KLE D+ + D +
Sbjct: 1013 EEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND 1072
Query: 898 LTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKH 951
++++ L+ K+ ++ L ++ S LQK ++++ + E+ ++E A K
Sbjct: 1073 KQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKV 1132
Query: 952 EEEKKELERKLSDLEKKMETS---------------------HNQCQELKARYERATSET 990
E+ + +L R+L ++ +++E + +E ++E +
Sbjct: 1133 EKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL 1192
Query: 991 KTKHE-------EILQNLQKTLLDTEDKLKGAREENSGLLQELEELRK-QADKAKAAQTA 1042
+ KH E + NLQ+ E + + E + +E++ K +A+ K +T
Sbjct: 1193 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTL 1252
Query: 1043 EDAMQIMEQMTKEKTETLASLEDTKQTNAKLQ---NELDTLKENNLKNVEELNKSKELLT 1099
ED Q+ E +K + ET S+ D AKLQ EL + + +L + K T
Sbjct: 1253 ED--QMNEHRSKAE-ETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYT 1309
Query: 1100 VENQKMEEFRKEIE---TLKQAAAQKSQ-----------QLSALQEENVKLAEELGRSRD 1145
Q++E+ ++++E K A A Q Q E +L L ++
Sbjct: 1310 ---QQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANS 1366
Query: 1146 EVTS-HQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
EV K E + +L E KK+ ++ +++A+E ++ S E+E
Sbjct: 1367 EVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIE 1426
Query: 1205 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1264
L +V NA+A +L + DK+ E K K E Q + Q + S T
Sbjct: 1427 DLMVDV---ERSNAAAAALDKKQRNF--DKILAEWKQKYEESQSELESSQKEARS--LST 1479
Query: 1265 QADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQ 1324
+ + + A E ++ L + +R+N++L+ ++ ++E L +G ++ + ++ +
Sbjct: 1480 ELFKLKNAYEESLEHLET----FKRENKNLQEEISDLTE-QLGSSGKTIHELEKVRKQLE 1534
Query: 1325 SKK 1327
++K
Sbjct: 1535 AEK 1537
Score = 115 bits (288), Expect = 3e-25
Identities = 154/805 (19%), Positives = 332/805 (41%), Gaps = 93/805 (11%)
Query: 285 STTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVSSRPSRTGL-LTETSSRY 343
+T +A A A+R+ A + A L + ++ V + S L L + +S
Sbjct: 1181 ATLQHEATAAALRKKHADSVAEL-----GEQIDNLQRVKQKLEKEKSEFKLELDDVTSNM 1235
Query: 344 ARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHV 403
+ I L++ + + + + ++ + + V TS +++ E
Sbjct: 1236 EQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENG---------- 1285
Query: 404 LELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEK 463
EL ++D+ ++ R K+ QLE+ KR++E EE K L A S +
Sbjct: 1286 -ELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLE-------EEVKAKNALAHALQSAR 1337
Query: 464 SRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQRE 523
L + + AEL+R L E++ + K E E
Sbjct: 1338 HDCDLLREQYEEETEAKAELQRVLSKAN------------SEVAQWRTKYETDAIQRTEE 1385
Query: 524 ITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH----ANKENSDVIALWKS 579
+ K+ R + ++ ++A+ L K L++++E + N+ AL K
Sbjct: 1386 LEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKK 1445
Query: 580 K--LETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ----- 632
+ + +A +Q EE + L + E L T++ K++ Y+ +E+L+
Sbjct: 1446 QRNFDKILAEWKQKYEESQSE----LESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 633 NQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEA 692
N+ E + E K + +++ LEA + +L A ++ +E K+ A
Sbjct: 1502 NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRA 1561
Query: 693 EIKVKELEV-LQAKCNEQTKVIDNFT-SQLKATEEKLLDLDALRKASSEGKSEMKKLRQQ 750
+++ +++ ++ K E+ + ++ + L+ + LDA ++ +E KK+
Sbjct: 1562 QLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGD 1621
Query: 751 LEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN-------LQENLSEVSQVKETL 803
L E Q+ H + S+ L+ +++L + L+EN++ V + L
Sbjct: 1622 LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1681
Query: 804 EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKF 863
+ EL+ L+ + ++ + ET ++ Q L + +K+ +L+ ++
Sbjct: 1682 QAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQT-- 1739
Query: 864 REKDEREEQLIKAKEKLENDI------AEIMKMSGDNSSQLTKMNDELRLKERDVEELQL 917
E +E ++ A+EK + I AE +K D S+ L +M + E+ +++LQ
Sbjct: 1740 -EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNM---EQTIKDLQH 1795
Query: 918 KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQ 977
+L +A E + +K + Q + K E +ELE +L +K+ S +
Sbjct: 1796 RLDEA-----------EQIALKGGKKQLQ---KLEARVRELENELEAEQKRNAESVKGMR 1841
Query: 978 ELKARYERATSETKTKHEEILQ------NLQKTLLDTEDKLKGAREENSGLLQELEELRK 1031
+ + R + T +T+ + +L+ LQ + + + + A E+ + L + +++
Sbjct: 1842 KSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1901
Query: 1032 QADKA-KAAQTAEDAMQIMEQMTKE 1055
+ D+A + A AE + + +++
Sbjct: 1902 ELDEAEERADIAESQVNKLRAKSRD 1926
Score = 100 bits (248), Expect = 1e-20
Identities = 112/570 (19%), Positives = 249/570 (43%), Gaps = 60/570 (10%)
Query: 332 RTGLLTETSSRYARKISGTTALQEALKEK-----------QQHIEQLLAERDLERAEVAK 380
RT L E + A+++ EA+ K Q IE L+ + + A A
Sbjct: 1382 RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAA 1441
Query: 381 ATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM------VEAADREKVELLNQLEEE 434
++ LA + +++ ELE+ + R++ ++ A E +E L + E
Sbjct: 1442 LDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRE 1501
Query: 435 KR----KVEDLQFRVEEESITKGDLEVATVSEKSRIMEL-----EKDLALRVQEVAELRR 485
+ ++ DL ++ T +LE ++ MEL E + +L +E LR
Sbjct: 1502 NKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRA 1561
Query: 486 RLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKAL 545
+LE N+ +++ ++++ E++E + +H R + SL+ A + + ++
Sbjct: 1562 QLEFNQIKAEIE------RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRV- 1614
Query: 546 YTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGT 605
+K+ + ++ +L HAN+ ++ + + S Q +++ ++ +
Sbjct: 1615 ---KKKMEGDLNEMEIQLSHANRMAAEA--------QKQVKSLQSLLKDTQIQLDDAVRA 1663
Query: 606 ETAEFAELKTQIEKMRLDYQHEIENLQNQ-QDSERAAHAKEMEALR-AKLMKVIKEKENS 663
+ E +E+ Q E+E L+ + +ER+ E E + ++ ++++ + S
Sbjct: 1664 ND-DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1722
Query: 664 LEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQL--- 720
L + K+D Q E+E+ + + + AE K K+ A E+ K + ++ L
Sbjct: 1723 LINQKKKMDADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1782
Query: 721 -KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITREL 779
K E+ + DL + + +K ++QL+ E +++ LE E AE + + + +
Sbjct: 1783 KKNMEQTIKDLQ--HRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGM 1840
Query: 780 QGRELKLTNL-------QENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETV 832
+ E ++ L ++NL + + + L+ +++ K + EA E+A + ++
Sbjct: 1841 RKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQ 1900
Query: 833 NKLHQKEEQFNMLSSDLEKLRENLADMEAK 862
++L + EE+ ++ S + KLR D+ K
Sbjct: 1901 HELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Score = 55.5 bits (132), Expect = 4e-07
Identities = 75/318 (23%), Positives = 138/318 (43%), Gaps = 48/318 (15%)
Query: 1025 ELEELRKQADKAKAAQT-------AEDAMQIMEQMTKEKTETLAS-LEDTKQTNAKLQNE 1076
+++ L K A++ K + ++A++ E KE E + S L++ ++Q E
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAE 894
Query: 1077 LDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKL 1136
D L + + ++L K+K L K++E + +E ++ A+ + + L++E
Sbjct: 895 QDNLADAE-ERCDQLIKNKIQL---EAKVKEMNERLEDEEEMNAELTAKKRKLEDE---- 946
Query: 1137 AEELGRSRDEV-TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSAL 1195
EL R D++ + K+E+E+ N+ +K+ EE A L + I + L
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENK-----------VKNLTEEMAGLDE---IIAKL 992
Query: 1196 LTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQL 1255
EK A E + + L+ E V TL KVKLE +V +LE L++ K+
Sbjct: 993 TKEKKALQEAHQQALDDLQAE-------EDKVNTLTKAKVKLEQQVDDLEGSLEQEKK-- 1043
Query: 1256 SSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDL--KMKVEMMSEAALNGNGDDL 1313
+ +R E + I+DL+ Q L ++K + ALN +D
Sbjct: 1044 ------VRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDE 1097
Query: 1314 NNYDSDDQEKQSKKKPRL 1331
S Q+K + + R+
Sbjct: 1098 QALGSQLQKKLKELQARI 1115
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 169 bits (429), Expect = 1e-41
Identities = 225/1014 (22%), Positives = 423/1014 (41%), Gaps = 138/1014 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 865 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 913
Query: 418 EAADREKVELLNQ----LEEEKRKVE--------------DLQFRVEEESITKGDLEVAT 459
A +E E+L++ LEEE+ + + DL+ ++EEE + L++
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE-ISSLQEKLEVTRT 518
V+ +++I +LE ++ + + +L + + LL+E IS L L
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERK-------------LLEERISDLTTNL-AEEE 1019
Query: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
+ + +T LK + E+ E++ EK +E E LK KLE + + IA
Sbjct: 1020 EKAKNLTKLKN----KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--- 1072
Query: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638
L+ IA + + + + L E A+ ++K+R + + I +LQ DSE
Sbjct: 1073 -DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Query: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
RAA R K K ++ LEA++++L+ D + E + QE + K
Sbjct: 1131 RAA--------RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 699 LE--------VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD----ALRKASSEGKSEMKK 746
L+ +Q + + ++ T QL+ + +LD L K +++ E++
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 747 LRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
L Q + E + K LE + SK S R K+ LQ + V+ + E +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 807 LQILKEKFAEASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADM 859
L + A S + Q +QE KL Q EE+ N L L++ E ++
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
E R QL +K+KL+ D A ++ + + K E+ + EE
Sbjct: 1363 E---RHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQK---EIENLTQQYEEKAAAY 1415
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
K + + LQ+ ++D+ V + +Q + LE+K ++ + N +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY 1467
Query: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKA 1038
+RA +E + K + L +L + L + + + N L E+E+L + D K
Sbjct: 1468 ADERDRAEAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLK---ENNLKNVEEL 1091
E + + +E +E L LED T+ +L+ + LK E +L+ +E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 1092 NKSKELLTVENQKMEEFRKEIETLKQ-----AAAQKS-----QQLSALQEENVKLAEE-- 1139
N+ K +++ E+ E+E ++ AAA+K + L + +K EE
Sbjct: 1587 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1140 --LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
L + + ++ Q+ E+ +++ K K K + + LQ+ ++
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1198 EKDAELEKLRNEV-TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
+ D E E+L E+ + L G NA L+ +K +LE ++ LE +L+E + +
Sbjct: 1705 QADLEKEELAEELASSLSGRNA-----------LQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 1257 SSSGNTDTQADEDER------AQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
+ S + E+ + S S L+R+N++L+ K+ M A
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Score = 169 bits (428), Expect = 2e-41
Identities = 237/1079 (21%), Positives = 457/1079 (42%), Gaps = 157/1079 (14%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 411 D-------QLRTMVEAADREKVELLNQLEEEKRKVEDLQF----------RVEEESITKG 453
+ QL+ + ++ ++L QLEEE+ + LQ ++E+E +
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 454 DLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK-----PAGDVDMSL----SLLQ 504
D E+ + E DL + E E + L K ++++ L Q
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 505 EISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQ-----------------K 540
E+ L+ KLE +D Q +I LK +EE Q K
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1111
Query: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE-----TAIASHQQAM 592
+I+ L L ++ +S ++ A K+ D+ + K++LE TA +A
Sbjct: 1112 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1171
Query: 593 EELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA-------- 643
E +V+ K L ET + Q+++MR + +E L Q + + A A
Sbjct: 1172 REQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228
Query: 644 --KEMEALRAKL------MKVIKEKENSLEA----IRSKLDKAEDQHLVEMEDTLNKLQ- 690
KE L +L + ++ K+ LEA ++SK E + E+ D ++KLQ
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE-RARAELNDKVHKLQN 1287
Query: 691 EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLLDLDALRKASSEGKS 742
E E L + K + K + + +SQL+ T+E KL LR+ E S
Sbjct: 1288 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 743 EMKKLRQQLEA---AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ---ENLSEV 796
+L +++EA E+ I L I+ + K ++ E Q ENL++
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1407
Query: 797 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
+ K +L+ K + + ++ V + ++ V+ L +K+ +F+ L ++ + +
Sbjct: 1408 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1467
Query: 857 AD----MEAKFREKDERE-------EQLIKAKEKLEN-------DIAEIMKMSGDNSSQL 898
AD EA+ REK+ + E+ ++AKE+LE ++ +++ D +
Sbjct: 1468 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1527
Query: 899 TKMNDELRLKERDVEELQLKL------TKANENASF-LQKSIEDMTVKAEQSQQEAAKKH 951
++ R E +EE++ +L +A E+A L+ +++ + + E+ Q +++
Sbjct: 1528 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1587
Query: 952 EEEKKELERKLSDLEKKMETSHNQCQ-----------ELKARYERATSETKTKHEEI--L 998
EE++++L+R+L + E ++E Q +LK +A S K + E I L
Sbjct: 1588 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1647
Query: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM-TKEKT 1057
+ LQ + D + +L+ AR + +E K+A +A D MQ+ E + E+
Sbjct: 1648 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----DLMQLQEDLAAAERA 1702
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
A LE +L EL + +E + + + +++EE + +E +
Sbjct: 1703 RKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 1118 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ESKFIK 1176
+ +QQ L E LA E ++ ++ Q+LE + L ++L EM+ +SKF
Sbjct: 1758 RVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1236
+A + + EK A + L+ + L+ + + + + K
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 1237 LELKVKNLELQL---KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQ 1292
+VK L+ QL +E ++++++ + DE + E+ +N++ L+R N+
Sbjct: 1875 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 817 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 870 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1022 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 986 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1041
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1196
Query: 1102 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1153
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1255
Query: 1154 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1212
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1256 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1310
Query: 1213 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1272
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1311 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1358
Query: 1273 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ E I LN + D ++K QD VE + E
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 102 bits (255), Expect = 2e-21
Identities = 144/670 (21%), Positives = 263/670 (39%), Gaps = 99/670 (14%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1291 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1343
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVE--E 447
E +D D+ E+EAK + R + LN QL + K+K++D VE E
Sbjct: 1344 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVEALE 1391
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 507
E + E+ ++++ EK A E + R + E + D+D L+ +
Sbjct: 1392 EGKKRFQKEIENLTQQYE----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 508 SLQEKLEVTRTDHQREITS--LKEHFGAREETHQKEIKAL---------YTATEKLSKEN 556
Q K + + ++ I+S E A E +KE KAL A E+L + N
Sbjct: 1448 KKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1506
Query: 557 ESLKSKLEHANKENSDV----IALWKSK--LETAIASHQQAMEEL--------------- 595
+ LK+++E DV L KSK LET + + +EEL
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566
Query: 596 ------KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EM 646
K F + L + E + Q+++ +Y+ E+E+ + Q+ AA K ++
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626
Query: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT-------LNKLQEAEIKVKEL 699
+ L + IK +E +++ +R KL E+ED +E E K K L
Sbjct: 1627 KDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685
Query: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLD----------------------LDALRKAS 737
E + E + Q +E+L + + L +
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1745
Query: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 797
E + M+ + ++ A +Q + L E E S A Q E + L+ L E+
Sbjct: 1746 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1805
Query: 798 -QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
VK + + L+ K A+ E+ R Q L QK+++ + +E R+
Sbjct: 1806 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916
+ + + + R +QL + E+ E + I +L + + R+V L+
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Query: 917 LKLTKANENA 926
KL + NE +
Sbjct: 1926 SKLRRGNETS 1935
Score = 58.2 bits (139), Expect = 6e-08
Identities = 64/283 (22%), Positives = 122/283 (43%), Gaps = 33/283 (11%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALAR---DGHDQHVLEL 406
+ + I QL E + E+ V KAT ++ ELA R ++ +L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 407 EAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
E + +LR+ + E K + + + + K+ L+ +VE+E+ K + AT S K +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK---QAATKSLKQK 1847
Query: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
+L K++ L+V++ ++ + + G+ + L+ +LE + QR
Sbjct: 1848 DKKL-KEILLQVEDERKMAEQYKEQAEKGNA--------RVKQLKRQLEEAEEESQR--- 1895
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK 568
A Q+E+ + E + +E +LKSKL N+
Sbjct: 1896 -----INANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 169 bits (429), Expect = 1e-41
Identities = 225/1014 (22%), Positives = 423/1014 (41%), Gaps = 138/1014 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 872 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 920
Query: 418 EAADREKVELLNQ----LEEEKRKVE--------------DLQFRVEEESITKGDLEVAT 459
A +E E+L++ LEEE+ + + DL+ ++EEE + L++
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE-ISSLQEKLEVTRT 518
V+ +++I +LE ++ + + +L + + LL+E IS L L
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERK-------------LLEERISDLTTNL-AEEE 1026
Query: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
+ + +T LK + E+ E++ EK +E E LK KLE + + IA
Sbjct: 1027 EKAKNLTKLKN----KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--- 1079
Query: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638
L+ IA + + + + L E A+ ++K+R + + I +LQ DSE
Sbjct: 1080 -DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Query: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
RAA R K K ++ LEA++++L+ D + E + QE + K
Sbjct: 1138 RAA--------RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 699 LE--------VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD----ALRKASSEGKSEMKK 746
L+ +Q + + ++ T QL+ + +LD L K +++ E++
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 747 LRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
L Q + E + K LE + SK S R K+ LQ + V+ + E +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 807 LQILKEKFAEASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADM 859
L + A S + Q +QE KL Q EE+ N L L++ E ++
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
E R QL +K+KL+ D A ++ + + K E+ + EE
Sbjct: 1370 E---RHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQK---EIENLTQQYEEKAAAY 1422
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
K + + LQ+ ++D+ V + +Q + LE+K ++ + N +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY 1474
Query: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKA 1038
+RA +E + K + L +L + L + + + N L E+E+L + D K
Sbjct: 1475 ADERDRAEAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLK---ENNLKNVEEL 1091
E + + +E +E L LED T+ +L+ + LK E +L+ +E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 1092 NKSKELLTVENQKMEEFRKEIETLKQ-----AAAQKS-----QQLSALQEENVKLAEE-- 1139
N+ K +++ E+ E+E ++ AAA+K + L + +K EE
Sbjct: 1594 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 1140 --LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
L + + ++ Q+ E+ +++ K K K + + LQ+ ++
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1198 EKDAELEKLRNEV-TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
+ D E E+L E+ + L G NA L+ +K +LE ++ LE +L+E + +
Sbjct: 1712 QADLEKEELAEELASSLSGRNA-----------LQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 1257 SSSGNTDTQADEDER------AQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
+ S + E+ + S S L+R+N++L+ K+ M A
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Score = 169 bits (428), Expect = 2e-41
Identities = 237/1079 (21%), Positives = 457/1079 (42%), Gaps = 157/1079 (14%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 411 D-------QLRTMVEAADREKVELLNQLEEEKRKVEDLQF----------RVEEESITKG 453
+ QL+ + ++ ++L QLEEE+ + LQ ++E+E +
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 454 DLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK-----PAGDVDMSL----SLLQ 504
D E+ + E DL + E E + L K ++++ L Q
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 505 EISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQ-----------------K 540
E+ L+ KLE +D Q +I LK +EE Q K
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK 1118
Query: 541 EIKALYTATEKLSKENESLKSKLEHANKENSDV---IALWKSKLE-----TAIASHQQAM 592
+I+ L L ++ +S ++ A K+ D+ + K++LE TA +A
Sbjct: 1119 KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAK 1178
Query: 593 EELKVS-FSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHA-------- 643
E +V+ K L ET + Q+++MR + +E L Q + + A A
Sbjct: 1179 REQEVTVLKKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235
Query: 644 --KEMEALRAKL------MKVIKEKENSLEA----IRSKLDKAEDQHLVEMEDTLNKLQ- 690
KE L +L + ++ K+ LEA ++SK E + E+ D ++KLQ
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGE-RARAELNDKVHKLQN 1294
Query: 691 EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE--------KLLDLDALRKASSEGKS 742
E E L + K + K + + +SQL+ T+E KL LR+ E S
Sbjct: 1295 EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 743 EMKKLRQQLEA---AEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQ---ENLSEV 796
+L +++EA E+ I L I+ + K ++ E Q ENL++
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQ 1414
Query: 797 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
+ K +L+ K + + ++ V + ++ V+ L +K+ +F+ L ++ + +
Sbjct: 1415 YEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKY 1474
Query: 857 AD----MEAKFREKDERE-------EQLIKAKEKLEN-------DIAEIMKMSGDNSSQL 898
AD EA+ REK+ + E+ ++AKE+LE ++ +++ D +
Sbjct: 1475 ADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV 1534
Query: 899 TKMNDELRLKERDVEELQLKL------TKANENASF-LQKSIEDMTVKAEQSQQEAAKKH 951
++ R E +EE++ +L +A E+A L+ +++ + + E+ Q +++
Sbjct: 1535 HELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQN 1594
Query: 952 EEEKKELERKLSDLEKKMETSHNQCQ-----------ELKARYERATSETKTKHEEI--L 998
EE++++L+R+L + E ++E Q +LK +A S K + E I L
Sbjct: 1595 EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQL 1654
Query: 999 QNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQM-TKEKT 1057
+ LQ + D + +L+ AR + +E K+A +A D MQ+ E + E+
Sbjct: 1655 RKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA-----DLMQLQEDLAAAERA 1709
Query: 1058 ETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQ 1117
A LE +L EL + +E + + + +++EE + +E +
Sbjct: 1710 RKQADLE-----KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 1118 AAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ESKFIK 1176
+ +QQ L E LA E ++ ++ Q+LE + L ++L EM+ +SKF
Sbjct: 1765 RVRKATQQAEQLSNE---LATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 1177 DADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVK 1236
+A + + EK A + L+ + L+ + + + + K
Sbjct: 1822 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1881
Query: 1237 LELKVKNLELQL---KENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQ 1292
+VK L+ QL +E ++++++ + DE + E+ +N++ L+R N+
Sbjct: 1882 GNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 817 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 870 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1029 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 986 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1041
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1203
Query: 1102 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1153
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1262
Query: 1154 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1212
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1263 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1317
Query: 1213 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1272
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1318 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1365
Query: 1273 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ E I LN + D ++K QD VE + E
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 102 bits (255), Expect = 2e-21
Identities = 144/670 (21%), Positives = 263/670 (39%), Gaps = 99/670 (14%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S TG+L E + + +L L++ Q+ +++ E + ++ + ++E+
Sbjct: 1298 SVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-------ETRQKLNVSTKLRQLEE 1350
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLN-QLEEEKRKVEDLQFRVE--E 447
E +D D+ E+EAK + R + LN QL + K+K++D VE E
Sbjct: 1351 ERNSLQDQLDE---EMEAKQNLER---------HISTLNIQLSDSKKKLQDFASTVEALE 1398
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEIS 507
E + E+ ++++ EK A E + R + E + D+D L+ +
Sbjct: 1399 EGKKRFQKEIENLTQQYE----EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 508 SLQEKLEVTRTDHQREITS--LKEHFGAREETHQKEIKAL---------YTATEKLSKEN 556
Q K + + ++ I+S E A E +KE KAL A E+L + N
Sbjct: 1455 KKQRKFDQLLAE-EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTN 1513
Query: 557 ESLKSKLEHANKENSDV----IALWKSK--LETAIASHQQAMEEL--------------- 595
+ LK+++E DV L KSK LET + + +EEL
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573
Query: 596 ------KVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAK---EM 646
K F + L + E + Q+++ +Y+ E+E+ + Q+ AA K ++
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633
Query: 647 EALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDT-------LNKLQEAEIKVKEL 699
+ L + IK +E +++ +R KL E+ED +E E K K L
Sbjct: 1634 KDLELQADSAIKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692
Query: 700 EVLQAKCNEQTKVIDNFTSQLKATEEKLLD----------------------LDALRKAS 737
E + E + Q +E+L + + L +
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEEL 1752
Query: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVS 797
E + M+ + ++ A +Q + L E E S A Q E + L+ L E+
Sbjct: 1753 EEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEME 1812
Query: 798 -QVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
VK + + L+ K A+ E+ R Q L QK+++ + +E R+
Sbjct: 1813 GAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916
+ + + + R +QL + E+ E + I +L + + R+V L+
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Query: 917 LKLTKANENA 926
KL + NE +
Sbjct: 1933 SKLRRGNETS 1942
Score = 58.2 bits (139), Expect = 6e-08
Identities = 64/283 (22%), Positives = 122/283 (43%), Gaps = 33/283 (11%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALAR---DGHDQHVLEL 406
+ + I QL E + E+ V KAT ++ ELA R ++ +L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 407 EAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
E + +LR+ + E K + + + + K+ L+ +VE+E+ K + AT S K +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK---QAATKSLKQK 1854
Query: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
+L K++ L+V++ ++ + + G+ + L+ +LE + QR
Sbjct: 1855 DKKL-KEILLQVEDERKMAEQYKEQAEKGNA--------RVKQLKRQLEEAEEESQR--- 1902
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANK 568
A Q+E+ + E + +E +LKSKL N+
Sbjct: 1903 -----INANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 169 bits (429), Expect = 1e-41
Identities = 225/1014 (22%), Positives = 423/1014 (41%), Gaps = 138/1014 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 872 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 920
Query: 418 EAADREKVELLNQ----LEEEKRKVE--------------DLQFRVEEESITKGDLEVAT 459
A +E E+L++ LEEE+ + + DL+ ++EEE + L++
Sbjct: 921 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE-ISSLQEKLEVTRT 518
V+ +++I +LE ++ + + +L + + LL+E IS L L
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERK-------------LLEERISDLTTNL-AEEE 1026
Query: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
+ + +T LK + E+ E++ EK +E E LK KLE + + IA
Sbjct: 1027 EKAKNLTKLKN----KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--- 1079
Query: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638
L+ IA + + + + L E A+ ++K+R + + I +LQ DSE
Sbjct: 1080 -DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1137
Query: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
RAA R K K ++ LEA++++L+ D + E + QE + K
Sbjct: 1138 RAA--------RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 699 LE--------VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD----ALRKASSEGKSEMKK 746
L+ +Q + + ++ T QL+ + +LD L K +++ E++
Sbjct: 1190 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 747 LRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
L Q + E + K LE + SK S R K+ LQ + V+ + E +
Sbjct: 1250 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1309
Query: 807 LQILKEKFAEASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADM 859
L + A S + Q +QE KL Q EE+ N L L++ E ++
Sbjct: 1310 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1369
Query: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
E R QL +K+KL+ D A ++ + + K E+ + EE
Sbjct: 1370 E---RHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQK---EIENLTQQYEEKAAAY 1422
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
K + + LQ+ ++D+ V + +Q + LE+K ++ + N +
Sbjct: 1423 DKLEKTKNRLQQELDDLVVDLDNQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY 1474
Query: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKA 1038
+RA +E + K + L +L + L + + + N L E+E+L + D K
Sbjct: 1475 ADERDRAEAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1533
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLK---ENNLKNVEEL 1091
E + + +E +E L LED T+ +L+ + LK E +L+ +E
Sbjct: 1534 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1593
Query: 1092 NKSKELLTVENQKMEEFRKEIETLKQ-----AAAQKS-----QQLSALQEENVKLAEE-- 1139
N+ K +++ E+ E+E ++ AAA+K + L + +K EE
Sbjct: 1594 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 1140 --LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
L + + ++ Q+ E+ +++ K K K + + LQ+ ++
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1711
Query: 1198 EKDAELEKLRNEV-TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
+ D E E+L E+ + L G NA L+ +K +LE ++ LE +L+E + +
Sbjct: 1712 QADLEKEELAEELASSLSGRNA-----------LQDEKRRLEARIAQLEEELEEEQGNME 1760
Query: 1257 SSSGNTDTQADEDER------AQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
+ S + E+ + S S L+R+N++L+ K+ M A
Sbjct: 1761 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1814
Score = 169 bits (428), Expect = 2e-41
Identities = 226/1056 (21%), Positives = 449/1056 (42%), Gaps = 151/1056 (14%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 879 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 938
Query: 411 D-------QLRTMVEAADREKVELLNQLEEEKRKVEDLQF----------RVEEESITKG 453
+ QL+ + ++ ++L QLEEE+ + LQ ++E+E +
Sbjct: 939 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 998
Query: 454 DLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK-----PAGDVDMSL----SLLQ 504
D E+ + E DL + E E + L K ++++ L Q
Sbjct: 999 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1058
Query: 505 EISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQKEIKALYTATEKLSKENE 557
E+ L+ KLE +D Q +I LK +EE Q AL ++++++N
Sbjct: 1059 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNN 1115
Query: 558 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK--VSFSKGLGTETAEFAELKT 615
+LK K+ SD+ + L++ A+ +A ++ + + L TE + +
Sbjct: 1116 ALK-KIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1170
Query: 616 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI---RSKLD 672
+++R + E+ L+ D E +H +++ +R K + ++E LE ++ LD
Sbjct: 1171 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1230
Query: 673 KAEDQHLVEMEDTLNKL-------QEAEIKVKELEV----LQAKCNEQTKVIDNFTSQLK 721
K + E D +L QE E K K+LE LQ+KC++ + ++
Sbjct: 1231 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 722 ATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781
+ +++++ +E + + KL + + + Q++ + E+ + +++ +L+
Sbjct: 1291 KLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Query: 782 RELKLTNLQENLSEVSQVKETLEKELQILK----------EKFAEASEEAVSVQRSMQET 831
E + +LQ+ L E + K+ LE+ + L + FA E ++ Q+
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407
Query: 832 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 891
+ L Q+ E+ LEK + L + + QL+ EK + +++
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467
Query: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAK 949
+ SS+ D + R+ E L L +A E A ++ +E + +KAE ++K
Sbjct: 1468 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1527
Query: 950 K------HEEEK---------KELERKLSDLEKKMETSHN-------QCQELKARYERAT 987
HE EK +E++ +L +LE +++ + + Q LK ++ER
Sbjct: 1528 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 988 SETKTKHEEILQNLQKTLLDTEDKLKGAREENS-------GLLQELEELRKQADKAKAAQ 1040
++EE + LQ+ L + E +L+ R++ + L +L++L QAD A +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD--SAIK 1645
Query: 1041 TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV 1100
E+A++ + ++ + + LED + + ++ T KEN K+K L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENE-------KKAKSLEAD 1695
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
Q E+ AAA+++++ + L++E +LAEEL S
Sbjct: 1696 LMQLQEDL---------AAAERARKQADLEKE--ELAEELASSLSG-------------- 1730
Query: 1161 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA 1220
N L + K+R I +EE Q ++ S + + + E+L NE L E ++A
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTA 1787
Query: 1221 KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ----LSSSSGNTDTQADEDERAQESQ 1276
+ S Q LE +L K+ +E +K + L + + Q +++ R +++
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1847
Query: 1277 IDFL---NSVIVDLQRKNQDLKMKVEMMSEAALNGN 1309
L + + ++ + +D + E E A GN
Sbjct: 1848 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1883
Score = 164 bits (416), Expect = 4e-40
Identities = 230/1036 (22%), Positives = 442/1036 (42%), Gaps = 111/1036 (10%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
+ T L E R + L+E L E + +E+ +AE K + ++E+
Sbjct: 905 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 391 ELALARDGHDQHVLE---LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
+L + LE EAK+ +L + D + +L + + + ++ DL + E
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ 504
E +L +S I ELE L QE+ +L+R+LE + A D ++ LQ
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQ 1082
Query: 505 -EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 563
+I+ L+ +L + Q + L + A++ K+I+ L L ++ +S ++
Sbjct: 1083 AQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 564 EHANKENSDV---IALWKSKLE-----TAIASHQQAMEELKVS-FSKGLGTETAEFAELK 614
A K+ D+ + K++LE TA +A E +V+ K L ET +
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---E 1198
Query: 615 TQIEKMRLDYQHEIENLQNQQDSERAAHA----------KEMEALRAKLMKV------IK 658
Q+++MR + +E L Q + + A A KE L +L + ++
Sbjct: 1199 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 659 EKENSLEA----IRSKLDKAEDQHLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVI 713
K+ LEA ++SK E E+ D ++KLQ E E L + K + K +
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 714 DNFTSQLKATEE--------KLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLE 762
+ +SQL+ T+E KL LR+ E S +L +++EA E+ I L
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 763 IEKNAESSKASSITRELQGRELKLTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASE 819
I+ + K ++ E Q ENL++ + K +L+ K + + +
Sbjct: 1378 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1437
Query: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDERE----- 870
+ V + ++ V+ L +K+ +F+ L ++ + + AD EA+ REK+ +
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497
Query: 871 --EQLIKAKEKLEN-------DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
E+ ++AKE+LE ++ +++ D + ++ R E +EE++ +L +
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557
Query: 922 ------ANENASF-LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL-------SDLEK 967
A E+A L+ +++ + + E+ Q +++EE++++L+R+L D K
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617
Query: 968 KMETSHNQCQELKARYE----RATSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSG 1021
+ + ++L+ + +A S K + E I L+ LQ + D + +L+ AR
Sbjct: 1618 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1677
Query: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTL 1080
+ +E K+A +A D MQ+ E + E+ A LE +L EL +
Sbjct: 1678 IFATAKENEKKAKSLEA-----DLMQLQEDLAAAERARKQADLE-----KEELAEELASS 1727
Query: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
+E + + + +++EE + +E + + +QQ L E LA E
Sbjct: 1728 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATER 1784
Query: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEK 1199
++ ++ Q+LE + L ++L EM+ +SKF +A + + EK
Sbjct: 1785 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1844
Query: 1200 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
A + L+ + L+ + + + + K +VK L+ QL+E + + +
Sbjct: 1845 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1904
Query: 1260 GNTDTQADEDERAQES 1275
N E + A ES
Sbjct: 1905 ANRRKLQRELDEATES 1920
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 912
Query: 817 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 913 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 972
Query: 870 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 973 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1029 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 986 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1041
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147
Query: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1203
Query: 1102 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1153
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1262
Query: 1154 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1212
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1263 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1317
Query: 1213 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1272
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1318 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1365
Query: 1273 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ E I LN + D ++K QD VE + E
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399
Score = 148 bits (374), Expect = 3e-35
Identities = 200/902 (22%), Positives = 375/902 (41%), Gaps = 144/902 (15%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
L+ L +K++ ++ LA D E A+ A + E+E H+ +L+ +D
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-----------HISDLQEDLDS 1136
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDL-----------QFRVEEESITKGDLEVATVS 461
R A+++K +L +LE K ++ED R +E ++ K L+ T S
Sbjct: 1137 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196
Query: 462 EKSRIMELEKDLALRVQEVAE-------LRRRLESNKP---------AGDVDMSLSLLQE 505
++++ E+ + A V+E+ E + L+ NK AG++ + QE
Sbjct: 1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1256
Query: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
+ ++KLE + Q + + + AR E + K KL E ES+ L
Sbjct: 1257 VEHKKKKLEAQVQELQSKCSDGER---ARAELNDK--------VHKLQNEVESVTGMLNE 1305
Query: 566 AN----KENSDVIALWKSKLETAIASHQQAMEELKVSFS-KGLGTETAEFAELKTQIEKM 620
A K DV +L +T ++ ++L VS + L E + + +
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1365
Query: 621 RLDYQHEIENLQNQ-QDSERAAH--AKEMEALRAKLMKVIKEKENSLE------AIRSKL 671
+ + + I L Q DS++ A +EAL + KE EN + A KL
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1425
Query: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS-----------QL 720
+K +++ E++D + L V LE Q K ++ N +S +
Sbjct: 1426 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1485
Query: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRE 778
+ E K L L + + E K E+++ + L+A + + ++ KN + S E
Sbjct: 1486 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1545
Query: 779 LQGRELK--LTNLQENLSEVSQVKETLEKELQILKEKFA--------EASEEAVSVQRSM 828
Q E+K L L++ L K LE +Q LK +F + E+ +QR +
Sbjct: 1546 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1605
Query: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
E +L + +Q + ++ +KL +L D+E + + E+ IK KL+ + +
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
+ D + ++ + E+ + L+ L + E+ + +++ + ++ E+ +E A
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 949 KKH------EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQ 1002
++EK+ LE +++ LE+++E + + R +AT + E L N
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA-----EQLSNEL 1780
Query: 1003 KTLLDTEDKLKGAREE----NSGLLQELEELRKQ----------ADKAKAAQTAEDAMQI 1048
T T K + AR++ N L +L E+ A +AK AQ E
Sbjct: 1781 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ---- 1836
Query: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK--ME 1106
+EQ +EK SL+ K+ LK + LL VE+++ E
Sbjct: 1837 VEQEAREKQAATKSLKQ---------------KDKKLKEI--------LLQVEDERKMAE 1873
Query: 1107 EFRKEIETLKQAAAQKSQQLSALQEENVKL---AEELGRSRDEVT-SHQKLEEERSVLNN 1162
+++++ E Q +QL +EE+ ++ +L R DE T S++ + E + L +
Sbjct: 1874 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Query: 1163 QL 1164
+L
Sbjct: 1934 KL 1935
Score = 147 bits (370), Expect = 9e-35
Identities = 162/801 (20%), Positives = 359/801 (44%), Gaps = 94/801 (11%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S + E ++A+ + T E K + ++++ + E A++A +G+ +Q
Sbjct: 1196 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1255
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
E+ + +LEA++ +L++ +R + EL +++ + + +VE + + E
Sbjct: 1256 EV-------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-- 1306
Query: 451 TKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRL-ESNKPAGDVDMSLSLLQEI-SS 508
+ + ++L KD+A ++ + + L E + +V L L+E +S
Sbjct: 1307 ------------EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1354
Query: 509 LQEKLEV---TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
LQ++L+ + + +R I++L +K+++ + E L + + + ++E+
Sbjct: 1355 LQDQLDEEMEAKQNLERHISTLNIQLS----DSKKKLQDFASTVEALEEGKKRFQKEIEN 1410
Query: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
++ + A + KLE QQ +++L V +L + +EK + +
Sbjct: 1411 LTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQ--------RQLVSNLEKKQRKFD 1461
Query: 626 H---EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 682
E +N+ ++ ER E K + + + E +LEA + +L++ EM
Sbjct: 1462 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEM 1520
Query: 683 EDTLNKLQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA------ 732
ED ++ + V ELE L+ + E ++ +L+ATE+ L L+
Sbjct: 1521 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1580
Query: 733 ------LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 786
L+ + + + ++L++QL E +++ ++ + + A++ ++L+G L
Sbjct: 1581 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAAKKKLEG---DL 1633
Query: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
+L+ + +E K+L+ L+ + + E + S E + E++ L
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693
Query: 847 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 906
+DL +L+E+LA E ++ D KE+L ++A +SG N+ Q DE R
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLE-------KEELAEELAS--SLSGRNALQ-----DEKR 1739
Query: 907 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ------SQQEAAKKHEEEKKELER 960
E + +L+ +L + N + + T +AEQ +++ A+K+E +++LER
Sbjct: 1740 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 961 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
+ +L K+ H +K++++ + + K ++ + +++ + + K ++++
Sbjct: 1800 QNKELRSKL---HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1856
Query: 1021 GL---LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1077
L L ++E+ RK A++ K + AE ++Q+ ++ E + KLQ EL
Sbjct: 1857 KLKEILLQVEDERKMAEQYK--EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1914
Query: 1078 DTLKENNLKNVEELNKSKELL 1098
D E+N E+N K L
Sbjct: 1915 DEATESNEAMGREVNALKSKL 1935
Score = 55.5 bits (132), Expect = 4e-07
Identities = 63/278 (22%), Positives = 120/278 (43%), Gaps = 33/278 (11%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1678 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1737
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALAR---DGHDQHVLEL 406
+ + I QL E + E+ V KAT ++ ELA R ++ +L
Sbjct: 1738 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1797
Query: 407 EAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
E + +LR+ + E K + + + + K+ L+ +VE+E+ K + AT S K +
Sbjct: 1798 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK---QAATKSLKQK 1854
Query: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
+L K++ L+V++ ++ + + G+ + L+ +LE + QR
Sbjct: 1855 DKKL-KEILLQVEDERKMAEQYKEQAEKGNA--------RVKQLKRQLEEAEEESQR--- 1902
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 563
A Q+E+ + E + +E +LKSKL
Sbjct: 1903 -----INANRRKLQRELDEATESNEAMGREVNALKSKL 1935
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 169 bits (429), Expect = 1e-41
Identities = 225/1014 (22%), Positives = 423/1014 (41%), Gaps = 138/1014 (13%)
Query: 358 KEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMV 417
KE+QQ E L E + + +++ T ++++L Q EL A+ +++R +
Sbjct: 865 KERQQKAENELKELEQKHSQL---TEEKNLLQEQL--------QAETELYAEAEEMRVRL 913
Query: 418 EAADREKVELLNQ----LEEEKRKVE--------------DLQFRVEEESITKGDLEVAT 459
A +E E+L++ LEEE+ + + DL+ ++EEE + L++
Sbjct: 914 AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 460 VSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQE-ISSLQEKLEVTRT 518
V+ +++I +LE ++ + + +L + + LL+E IS L L
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERK-------------LLEERISDLTTNL-AEEE 1019
Query: 519 DHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWK 578
+ + +T LK + E+ E++ EK +E E LK KLE + + IA
Sbjct: 1020 EKAKNLTKLKN----KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA--- 1072
Query: 579 SKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSE 638
L+ IA + + + + L E A+ ++K+R + + I +LQ DSE
Sbjct: 1073 -DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIR-ELEGHISDLQEDLDSE 1130
Query: 639 RAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKE 698
RAA R K K ++ LEA++++L+ D + E + QE + K
Sbjct: 1131 RAA--------RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 699 LE--------VLQAKCNEQTKVIDNFTSQLKATEEKLLDLD----ALRKASSEGKSEMKK 746
L+ +Q + + ++ T QL+ + +LD L K +++ E++
Sbjct: 1183 LDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 747 LRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKE 806
L Q + E + K LE + SK S R K+ LQ + V+ + E +
Sbjct: 1243 LGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGK 1302
Query: 807 LQILKEKFAEASEEAVSVQRSMQETV-------NKLHQKEEQFNMLSSDLEKLRENLADM 859
L + A S + Q +QE KL Q EE+ N L L++ E ++
Sbjct: 1303 AIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNL 1362
Query: 860 EAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKL 919
E R QL +K+KL+ D A ++ + + K E+ + EE
Sbjct: 1363 E---RHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQK---EIENLTQQYEEKAAAY 1415
Query: 920 TKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQEL 979
K + + LQ+ ++D+ V + +Q + LE+K ++ + N +
Sbjct: 1416 DKLEKTKNRLQQELDDLVVDLDNQRQLVS--------NLEKKQRKFDQLLAEEKNISSKY 1467
Query: 980 KARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKA 1038
+RA +E + K + L +L + L + + + N L E+E+L + D K
Sbjct: 1468 ADERDRAEAEAREKETKAL-SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKN 1526
Query: 1039 AQTAEDAMQIMEQMTKEKTETLASLED----TKQTNAKLQNELDTLK---ENNLKNVEEL 1091
E + + +E +E L LED T+ +L+ + LK E +L+ +E
Sbjct: 1527 VHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ 1586
Query: 1092 NKSKELLTVENQKMEEFRKEIETLKQ-----AAAQKS-----QQLSALQEENVKLAEE-- 1139
N+ K +++ E+ E+E ++ AAA+K + L + +K EE
Sbjct: 1587 NEEKRRQL--QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 1140 --LGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLT 1197
L + + ++ Q+ E+ +++ K K K + + LQ+ ++
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARK 1704
Query: 1198 EKDAELEKLRNEV-TVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLS 1256
+ D E E+L E+ + L G NA L+ +K +LE ++ LE +L+E + +
Sbjct: 1705 QADLEKEELAEELASSLSGRNA-----------LQDEKRRLEARIAQLEEELEEEQGNME 1753
Query: 1257 SSSGNTDTQADEDER------AQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEA 1304
+ S + E+ + S S L+R+N++L+ K+ M A
Sbjct: 1754 AMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGA 1807
Score = 169 bits (428), Expect = 2e-41
Identities = 226/1056 (21%), Positives = 449/1056 (42%), Gaps = 151/1056 (14%)
Query: 354 QEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ---ELALARDGHDQHVLELEAKM 410
+ LKE +Q QL E++L + ++ T E E+ LA + ++ + E+EA++
Sbjct: 872 ENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARL 931
Query: 411 D-------QLRTMVEAADREKVELLNQLEEEKRKVEDLQF----------RVEEESITKG 453
+ QL+ + ++ ++L QLEEE+ + LQ ++E+E +
Sbjct: 932 EEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMD 991
Query: 454 DLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNK-----PAGDVDMSL----SLLQ 504
D E+ + E DL + E E + L K ++++ L Q
Sbjct: 992 DQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQ 1051
Query: 505 EISSLQEKLEVTRTDH-------QREITSLKEHFGAREETHQKEIKALYTATEKLSKENE 557
E+ L+ KLE +D Q +I LK +EE Q AL ++++++N
Sbjct: 1052 ELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ---AALARLDDEIAQKNN 1108
Query: 558 SLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELK--VSFSKGLGTETAEFAELKT 615
+LK K+ SD+ + L++ A+ +A ++ + + L TE + +
Sbjct: 1109 ALK-KIRELEGHISDL----QEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA 1163
Query: 616 QIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAI---RSKLD 672
+++R + E+ L+ D E +H +++ +R K + ++E LE ++ LD
Sbjct: 1164 TQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLD 1223
Query: 673 KAEDQHLVEMEDTLNKL-------QEAEIKVKELEV----LQAKCNEQTKVIDNFTSQLK 721
K + E D +L QE E K K+LE LQ+KC++ + ++
Sbjct: 1224 KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 722 ATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQG 781
+ +++++ +E + + KL + + + Q++ + E+ + +++ +L+
Sbjct: 1284 KLQN---EVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Query: 782 RELKLTNLQENLSEVSQVKETLEKELQILK----------EKFAEASEEAVSVQRSMQET 831
E + +LQ+ L E + K+ LE+ + L + FA E ++ Q+
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400
Query: 832 VNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMS 891
+ L Q+ E+ LEK + L + + QL+ EK + +++
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460
Query: 892 GDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIE--DMTVKAEQSQQEAAK 949
+ SS+ D + R+ E L L +A E A ++ +E + +KAE ++K
Sbjct: 1461 KNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSK 1520
Query: 950 K------HEEEK---------KELERKLSDLEKKMETSHN-------QCQELKARYERAT 987
HE EK +E++ +L +LE +++ + + Q LK ++ER
Sbjct: 1521 DDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 988 SETKTKHEEILQNLQKTLLDTEDKLKGAREENS-------GLLQELEELRKQADKAKAAQ 1040
++EE + LQ+ L + E +L+ R++ + L +L++L QAD A +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQAD--SAIK 1638
Query: 1041 TAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTV 1100
E+A++ + ++ + + LED + + ++ T KEN K+K L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEI---FATAKENE-------KKAKSLEAD 1688
Query: 1101 ENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVL 1160
Q E+ AAA+++++ + L++E +LAEEL S
Sbjct: 1689 LMQLQEDL---------AAAERARKQADLEKE--ELAEELASSLSG-------------- 1723
Query: 1161 NNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASA 1220
N L + K+R I +EE Q ++ S + + + E+L NE L E ++A
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATERSTA 1780
Query: 1221 KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ----LSSSSGNTDTQADEDERAQESQ 1276
+ S Q LE +L K+ +E +K + L + + Q +++ R +++
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAA 1840
Query: 1277 IDFL---NSVIVDLQRKNQDLKMKVEMMSEAALNGN 1309
L + + ++ + +D + E E A GN
Sbjct: 1841 TKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGN 1876
Score = 164 bits (416), Expect = 4e-40
Identities = 230/1036 (22%), Positives = 442/1036 (42%), Gaps = 111/1036 (10%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
+ T L E R + L+E L E + +E+ +AE K + ++E+
Sbjct: 898 AETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 391 ELALARDGHDQHVLE---LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEE 447
+L + LE EAK+ +L + D + +L + + + ++ DL + E
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 448 ESITKGDLEVATVSEKSRIMELEKDLALRV---QEVAELRRRLESNKPAGDVDMSLSLLQ 504
E +L +S I ELE L QE+ +L+R+LE + A D ++ LQ
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGD--ASDFHEQIADLQ 1075
Query: 505 -EISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 563
+I+ L+ +L + Q + L + A++ K+I+ L L ++ +S ++
Sbjct: 1076 AQIAELKMQLAKKEEELQAALARLDDEI-AQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 564 EHANKENSDV---IALWKSKLE-----TAIASHQQAMEELKVS-FSKGLGTETAEFAELK 614
A K+ D+ + K++LE TA +A E +V+ K L ET +
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH---E 1191
Query: 615 TQIEKMRLDYQHEIENLQNQQDSERAAHA----------KEMEALRAKLMKV------IK 658
Q+++MR + +E L Q + + A A KE L +L + ++
Sbjct: 1192 AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 659 EKENSLEA----IRSKLDKAEDQHLVEMEDTLNKLQ-EAEIKVKELEVLQAKCNEQTKVI 713
K+ LEA ++SK E E+ D ++KLQ E E L + K + K +
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERAR-AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 714 DNFTSQLKATEE--------KLLDLDALRKASSEGKSEMKKLRQQLEAA---EKQIKHLE 762
+ +SQL+ T+E KL LR+ E S +L +++EA E+ I L
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 763 IEKNAESSKASSITRELQGRELKLTNLQ---ENLSEVSQVKETLEKELQILKEKFAEASE 819
I+ + K ++ E Q ENL++ + K +L+ K + + +
Sbjct: 1371 IQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELD 1430
Query: 820 EAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLAD----MEAKFREKDERE----- 870
+ V + ++ V+ L +K+ +F+ L ++ + + AD EA+ REK+ +
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490
Query: 871 --EQLIKAKEKLEN-------DIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTK 921
E+ ++AKE+LE ++ +++ D + ++ R E +EE++ +L +
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550
Query: 922 ------ANENASF-LQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKL-------SDLEK 967
A E+A L+ +++ + + E+ Q +++EE++++L+R+L D K
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610
Query: 968 KMETSHNQCQELKARYE----RATSETKTKHEEI--LQNLQKTLLDTEDKLKGAREENSG 1021
+ + ++L+ + +A S K + E I L+ LQ + D + +L+ AR
Sbjct: 1611 QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDE 1670
Query: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQM-TKEKTETLASLEDTKQTNAKLQNELDTL 1080
+ +E K+A +A D MQ+ E + E+ A LE +L EL +
Sbjct: 1671 IFATAKENEKKAKSLEA-----DLMQLQEDLAAAERARKQADLE-----KEELAEELASS 1720
Query: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
+E + + + +++EE + +E + + +QQ L E LA E
Sbjct: 1721 LSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE---LATER 1777
Query: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKR-ESKFIKDADEEKASLQKSISITSALLTEK 1199
++ ++ Q+LE + L ++L EM+ +SKF +A + + EK
Sbjct: 1778 STAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK 1837
Query: 1200 DAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSS 1259
A + L+ + L+ + + + + K +VK L+ QL+E + + +
Sbjct: 1838 QAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRIN 1897
Query: 1260 GNTDTQADEDERAQES 1275
N E + A ES
Sbjct: 1898 ANRRKLQRELDEATES 1913
Score = 149 bits (376), Expect = 2e-35
Identities = 145/574 (25%), Positives = 259/574 (45%), Gaps = 54/574 (9%)
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
Q+ E E A+ + Q E +L L++ S++++ K L+++LQ E +AE
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAE 905
Query: 817 ASEEAVSVQRSMQETVNKLH-------QKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
A E V + QE LH ++E++ L ++ +K+ + + D+E + E++
Sbjct: 906 AEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAA 965
Query: 870 EEQL----IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANEN 925
++L + A+ K++ EI+ M N+ K++ E +L E + +L L + E
Sbjct: 966 RQKLQLEKVTAEAKIKKLEDEILVMDDQNN----KLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 926 ASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYER 985
A L K +++ + KK E+ ++ELE+ LE H Q +L+A+
Sbjct: 1022 AKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 986 ATSETKTKHEEI---LQNLQKTLLDTEDKLKGAREENSGLLQELEEL-RKQADKAKAAQT 1041
+ K EE+ L L + + LK RE + E+L ++A + KA +
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140
Query: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVE 1101
D + +E + E +TL S ++ AK + E+ LK K ++E +S E E
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK----KALDEETRSHEAQVQE 1196
Query: 1102 -----NQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEE---LGRSRDEVTSHQKL 1153
Q +EE +++E K+A A + L++EN LA E LG+++ EV H+K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV-EHKKK 1255
Query: 1154 EEERSVLNNQLLEMKKRESKFIK-DADEEKASLQKSISITSALLTEKDAELEKLRNEVTV 1212
+ E V Q L+ K + + + + +++ LQ + + +L E + + KL +V
Sbjct: 1256 KLEAQV---QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV-- 1310
Query: 1213 LRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERA 1272
AS S Q L ++ + +L V QL+E + L Q DE+ A
Sbjct: 1311 -----ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQD-------QLDEEMEA 1358
Query: 1273 Q---ESQIDFLNSVIVDLQRKNQDLKMKVEMMSE 1303
+ E I LN + D ++K QD VE + E
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392
Score = 148 bits (374), Expect = 3e-35
Identities = 200/902 (22%), Positives = 375/902 (41%), Gaps = 144/902 (15%)
Query: 353 LQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQ 412
L+ L +K++ ++ LA D E A+ A + E+E H+ +L+ +D
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEG-----------HISDLQEDLDS 1129
Query: 413 LRTMVEAADREKVELLNQLEEEKRKVEDL-----------QFRVEEESITKGDLEVATVS 461
R A+++K +L +LE K ++ED R +E ++ K L+ T S
Sbjct: 1130 ERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1189
Query: 462 EKSRIMELEKDLALRVQEVAE-------LRRRLESNKP---------AGDVDMSLSLLQE 505
++++ E+ + A V+E+ E + L+ NK AG++ + QE
Sbjct: 1190 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQE 1249
Query: 506 ISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
+ ++KLE + Q + + + AR E + K KL E ES+ L
Sbjct: 1250 VEHKKKKLEAQVQELQSKCSDGER---ARAELNDK--------VHKLQNEVESVTGMLNE 1298
Query: 566 AN----KENSDVIALWKSKLETAIASHQQAMEELKVSFS-KGLGTETAEFAELKTQIEKM 620
A K DV +L +T ++ ++L VS + L E + + +
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEA 1358
Query: 621 RLDYQHEIENLQNQ-QDSERAAH--AKEMEALRAKLMKVIKEKENSLE------AIRSKL 671
+ + + I L Q DS++ A +EAL + KE EN + A KL
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKL 1418
Query: 672 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS-----------QL 720
+K +++ E++D + L V LE Q K ++ N +S +
Sbjct: 1419 EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEA 1478
Query: 721 KATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHL--EIEKNAESSKASSITRE 778
+ E K L L + + E K E+++ + L+A + + ++ KN + S E
Sbjct: 1479 REKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALE 1538
Query: 779 LQGRELK--LTNLQENLSEVSQVKETLEKELQILKEKFA--------EASEEAVSVQRSM 828
Q E+K L L++ L K LE +Q LK +F + E+ +QR +
Sbjct: 1539 TQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQL 1598
Query: 829 QETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIM 888
E +L + +Q + ++ +KL +L D+E + + E+ IK KL+ + +
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 889 KMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAA 948
+ D + ++ + E+ + L+ L + E+ + +++ + ++ E+ +E A
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 949 KKH------EEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQ 1002
++EK+ LE +++ LE+++E + + R +AT + E L N
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQA-----EQLSNEL 1773
Query: 1003 KTLLDTEDKLKGAREE----NSGLLQELEELRKQ----------ADKAKAAQTAEDAMQI 1048
T T K + AR++ N L +L E+ A +AK AQ E
Sbjct: 1774 ATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ---- 1829
Query: 1049 MEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK--ME 1106
+EQ +EK SL+ K+ LK + LL VE+++ E
Sbjct: 1830 VEQEAREKQAATKSLKQ---------------KDKKLKEI--------LLQVEDERKMAE 1866
Query: 1107 EFRKEIETLKQAAAQKSQQLSALQEENVKL---AEELGRSRDEVT-SHQKLEEERSVLNN 1162
+++++ E Q +QL +EE+ ++ +L R DE T S++ + E + L +
Sbjct: 1867 QYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Query: 1163 QL 1164
+L
Sbjct: 1927 KL 1928
Score = 147 bits (370), Expect = 9e-35
Identities = 162/801 (20%), Positives = 359/801 (44%), Gaps = 94/801 (11%)
Query: 331 SRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQ 390
S + E ++A+ + T E K + ++++ + E A++A +G+ +Q
Sbjct: 1189 SHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQ 1248
Query: 391 ELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESI 450
E+ + +LEA++ +L++ +R + EL +++ + + +VE + + E
Sbjct: 1249 EV-------EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEA-- 1299
Query: 451 TKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRRL-ESNKPAGDVDMSLSLLQEI-SS 508
+ + ++L KD+A ++ + + L E + +V L L+E +S
Sbjct: 1300 ------------EGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNS 1347
Query: 509 LQEKLEV---TRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEH 565
LQ++L+ + + +R I++L +K+++ + E L + + + ++E+
Sbjct: 1348 LQDQLDEEMEAKQNLERHISTLNIQLS----DSKKKLQDFASTVEALEEGKKRFQKEIEN 1403
Query: 566 ANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625
++ + A + KLE QQ +++L V +L + +EK + +
Sbjct: 1404 LTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQ--------RQLVSNLEKKQRKFD 1454
Query: 626 H---EIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEM 682
E +N+ ++ ER E K + + + E +LEA + +L++ EM
Sbjct: 1455 QLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEM 1513
Query: 683 EDTLNKLQEAEIKVKELE----VLQAKCNEQTKVIDNFTSQLKATEEKLLDLDA------ 732
ED ++ + V ELE L+ + E ++ +L+ATE+ L L+
Sbjct: 1514 EDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALK 1573
Query: 733 ------LRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 786
L+ + + + ++L++QL E +++ ++ + + A++ ++L+G L
Sbjct: 1574 GQFERDLQARDEQNEEKRRQLQRQLHEYETELE----DERKQRALAAAAKKKLEG---DL 1626
Query: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
+L+ + +E K+L+ L+ + + E + S E + E++ L
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686
Query: 847 SDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELR 906
+DL +L+E+LA E ++ D KE+L ++A +SG N+ Q DE R
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLE-------KEELAEELAS--SLSGRNALQ-----DEKR 1732
Query: 907 LKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQ------SQQEAAKKHEEEKKELER 960
E + +L+ +L + N + + T +AEQ +++ A+K+E +++LER
Sbjct: 1733 RLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 961 KLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENS 1020
+ +L K+ H +K++++ + + K ++ + +++ + + K ++++
Sbjct: 1793 QNKELRSKL---HEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDK 1849
Query: 1021 GL---LQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNEL 1077
L L ++E+ RK A++ K + AE ++Q+ ++ E + KLQ EL
Sbjct: 1850 KLKEILLQVEDERKMAEQYK--EQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL 1907
Query: 1078 DTLKENNLKNVEELNKSKELL 1098
D E+N E+N K L
Sbjct: 1908 DEATESNEAMGREVNALKSKL 1928
Score = 55.5 bits (132), Expect = 4e-07
Identities = 63/278 (22%), Positives = 120/278 (43%), Gaps = 33/278 (11%)
Query: 299 VMATTSASLKRSPS--ASSLSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEA 356
+ AT + K++ S A + +A++ +R E + A +SG ALQ+
Sbjct: 1671 IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDE 1730
Query: 357 LKEKQQHIEQLLAERDLERA-------EVAKATSHVGEIEQELALAR---DGHDQHVLEL 406
+ + I QL E + E+ V KAT ++ ELA R ++ +L
Sbjct: 1731 KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQL 1790
Query: 407 EAKMDQLRTMV-EAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
E + +LR+ + E K + + + + K+ L+ +VE+E+ K + AT S K +
Sbjct: 1791 ERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREK---QAATKSLKQK 1847
Query: 466 IMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQREIT 525
+L K++ L+V++ ++ + + G+ + L+ +LE + QR
Sbjct: 1848 DKKL-KEILLQVEDERKMAEQYKEQAEKGNA--------RVKQLKRQLEEAEEESQR--- 1895
Query: 526 SLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKL 563
A Q+E+ + E + +E +LKSKL
Sbjct: 1896 -----INANRRKLQRELDEATESNEAMGREVNALKSKL 1928
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 169 bits (427), Expect = 2e-41
Identities = 214/1033 (20%), Positives = 439/1033 (42%), Gaps = 108/1033 (10%)
Query: 346 KISGTTALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLE 405
K + T +KE+ Q + LA+ + +R E+ + + + + +L L +++L+
Sbjct: 842 KSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLD 901
Query: 406 LEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSEKSR 465
E + DQL ++ QLE K++++ R E+E +L +
Sbjct: 902 AEERCDQL-----------IKAKFQLE---AKIKEVTERAEDEEEINAELTAKKRKLEDE 947
Query: 466 IMELEK---DLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
EL+K DL L + +V E + NK + L + I+ L + + + HQ+
Sbjct: 948 CSELKKDIDDLELTLAKV-EKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 582
+ L + + ++ +L KL ++ E L+S LE K D + K KLE
Sbjct: 1007 ALDDL--------QAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD-LERNKRKLE 1057
Query: 583 TAIASHQQAMEEL---KVSFSKGLGTETAEFAELKTQIE---KMRLDYQHEIENLQNQQD 636
+ Q+++ +L K + L + E+ +L++++E + L +Q +I+ LQ + +
Sbjct: 1058 GDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIE 1117
Query: 637 SERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKV 696
E + A RAK K + LE + +L++A ++E LNK +EAE
Sbjct: 1118 -ELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE--LNKKREAEFLK 1174
Query: 697 KELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEK 756
++ +A + V + E +D L++ + + E + + +++
Sbjct: 1175 LRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSS 1234
Query: 757 QIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAE 816
++ + K ++ +L K +Q +LSE++ K L+ E L + E
Sbjct: 1235 SMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEE 1294
Query: 817 ASEEAVSVQRSMQ-------ETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDER 869
+ RS Q E +L ++ + N L+ L+ R + + ++ E+ E
Sbjct: 1295 KESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEG 1354
Query: 870 EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK--------ERDVEELQLKLTK 921
+ +L +A K +++A+ ++ Q T+ +E + K E VE + K
Sbjct: 1355 KAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCAS 1414
Query: 922 ANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKA 981
+ LQ +ED+ V E++ AA L++K + +K + +C+E +A
Sbjct: 1415 LEKTKQRLQGEVEDLMVDVERANSLAA--------ALDKKQRNFDKVLAEWKTKCEESQA 1466
Query: 982 RYERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQ-ADKAKAAQ 1040
E + E+++ E+ + L+ + D+L+ + EN L QE+ +L +Q A+ K
Sbjct: 1467 ELEASLKESRSLSTELFK-LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH 1525
Query: 1041 TAEDAMQIME------QMTKEKTETLASLEDTKQTNAKLQ----------------NELD 1078
E + + +E Q+ E+ E E+ K +L+ E++
Sbjct: 1526 ELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIE 1585
Query: 1079 TLKENNLKNVE--------ELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKSQQLSAL 1129
LK N + VE E+ E + ++ +KME EIE L A Q ++ L L
Sbjct: 1586 QLKRNYQRTVETMQSALDAEVRSRNEAIRLK-KKMEGDLNEIEIQLSHANRQAAETLKHL 1644
Query: 1130 QEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1189
+ +L + D + + L+E QL +++R + + +E +A+L++
Sbjct: 1645 RSVQGQLKDTQLHLDDALRGQEDLKE-------QLAIVERRANLLQAEVEELRATLEQ-- 1695
Query: 1190 SITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLK 1249
T + EL V +L +N SL + LE+D ++L+ +V++ +
Sbjct: 1696 --TERARKLAEQELLDSNERVQLLHTQNT---SLIHTKKKLETDLMQLQSEVEDASRDAR 1750
Query: 1250 ENKRQLSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGN 1309
+ + + + A+E ++ Q++ L + +L++ +DL+ +++ + AL G
Sbjct: 1751 NAEEKAKKAITDAAMMAEELKKEQDTSA-HLERMKKNLEQTVKDLQHRLDEAEQLALKGG 1809
Query: 1310 GDDLNNYDSDDQE 1322
+ ++ +E
Sbjct: 1810 KKQIQKLETRIRE 1822
Score = 157 bits (396), Expect = 9e-38
Identities = 245/1113 (22%), Positives = 475/1113 (42%), Gaps = 185/1113 (16%)
Query: 268 KYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASSLSSMSSVASSVS 327
K+ L A + +VT+ A+ A +R + + LK+ L+ ++ V
Sbjct: 913 KFQLEAKIKEVTERA-EDEEEINAELTAKKRKLEDECSELKKDIDDLELT-LAKVEKEKH 970
Query: 328 SRPSRTGLLTETSSRYARKISGTTALQEALKEK-QQHIEQLLAERDLERAEVAKATSHVG 386
+ ++ LTE S I+ T ++AL+E QQ ++ L AE D + +
Sbjct: 971 ATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED--------KVNSLN 1022
Query: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446
+ + +L +Q V +LE+ ++Q + + +R K +L L+ + + DL+ +
Sbjct: 1023 KTKSKL-------EQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQ 1075
Query: 447 E--ESITKGDLEVATVSEKSRIMELEKDLALRVQE-VAELRRRLESNKPAGDVDMSLSLL 503
+ E + K D E + K +E E+ L L+ Q+ + EL+ R+E + + + +
Sbjct: 1076 QLDERLKKKDFEYCQLQSK---VEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT--- 1129
Query: 504 QEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEKLSKENES----L 559
+ K E R+D+ RE+ L E +E + + +L+K+ E+ L
Sbjct: 1130 ------RAKTEKQRSDYARELEELSERL--------EEAGGVTSTQIELNKKREAEFLKL 1175
Query: 560 KSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEK 619
+ LE A ++ ++A + K ++A LG + +K ++EK
Sbjct: 1176 RRDLEEATLQHEAMVAALRKKHADSVAE---------------LGEQIDNLQRVKQKLEK 1220
Query: 620 MRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHL 679
+ +++ EI++L + +S + +A L K+ + E+ L R K ++ + + L
Sbjct: 1221 EKSEFKLEIDDLSSSMES--------VSKSKANLEKICRTLEDQLSEARGKNEEIQ-RSL 1271
Query: 680 VEMEDTLNKLQ----EAEIKVKELEVLQAKCNEQTKVIDNFTSQLKAT-EEKLLDLDALR 734
E+ ++LQ E +++E E + ++ + + T +LK EE+ +AL
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Query: 735 KASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLS 794
A + + LR+Q E E+Q E+++ SKA+S Q R T+ +
Sbjct: 1332 HALQSSRHDCDLLREQYE--EEQEGKAELQRAL--SKANS--EVAQWRTKYETDAIQRTE 1385
Query: 795 EVSQVKETLEKELQILKEKFAEASEEAVSVQRS---MQETVNKLHQKEEQFNMLSSDLEK 851
E+ + K+ L + LQ +E+ + + S++++ +Q V L E+ N L++ L+K
Sbjct: 1386 ELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 852 LRENL---------------ADMEAKFREKDEREEQLIKAK-----------------EK 879
+ N A++EA +E +L K K +
Sbjct: 1446 KQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKN 1505
Query: 880 LENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA-----NENASFLQKSIE 934
LE +IA++ + +N + ++ + E + ++QL L +A +E A L+ +E
Sbjct: 1506 LEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565
Query: 935 DMTVKAEQSQQEAAKKHEEE--KKELERKLSD-----------------LEKKMETSHNQ 975
VK+E ++ A K E E K+ +R + L+KKME N+
Sbjct: 1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625
Query: 976 CQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGAR---------EENSGLLQ-E 1025
+ + R +ET + L+ T L +D L+G E + LLQ E
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAE 1685
Query: 1026 LEELR---KQADKAK--AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTL 1080
+EELR +Q ++A+ A Q D+ + ++ + + T + + + + +LQ+E++
Sbjct: 1686 VEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVED- 1744
Query: 1081 KENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140
+ +N EE K+K+ +T EE +KE +T S L +++ + ++L
Sbjct: 1745 ASRDARNAEE--KAKKAITDAAMMAEELKKEQDT--------SAHLERMKKNLEQTVKDL 1794
Query: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKD 1200
DE ++L + Q LE + RE +F + +++K TE
Sbjct: 1795 QHRLDEA---EQLALKGGKKQIQKLETRIRELEFELEGEQKKN-------------TESV 1838
Query: 1201 AELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1260
L K V L ++ + +Q L KL++KVK+ + Q +E Q ++
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVD---KLQVKVKSYKRQAEEADEQANAHLT 1895
Query: 1261 NTDTQADEDERAQESQIDFLNSVIVDLQRKNQD 1293
E E A+E + D S + L+ K +D
Sbjct: 1896 KFRKAQHELEEAEE-RADIAESQVNKLRAKTRD 1927
Score = 146 bits (368), Expect = 2e-34
Identities = 150/703 (21%), Positives = 309/703 (43%), Gaps = 76/703 (10%)
Query: 681 EMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDL----DALRKA 736
E + T ++L ++E K KELE K + ++ Q++A E LLD D L KA
Sbjct: 856 EFQKTKDELAKSEAKRKELE---EKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKA 912
Query: 737 SSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQENLSEV 796
+ ++++K++ ++ E E+ L +K + S + +++ EL L +++
Sbjct: 913 KFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 972
Query: 797 SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENL 856
+ L +EL L E A+ + E ++Q + Q+ ++ L +E++ N L+ KL + +
Sbjct: 973 ENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQV 1032
Query: 857 ADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQ 916
D+E+ ++ + L + K KLE D+ + D + ++++ L+ K+ + +LQ
Sbjct: 1033 EDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQ 1092
Query: 917 LKLTKANENASFLQKSIEDMTVKAEQSQQE------AAKKHEEEKKELERKLSDLEKKME 970
K+ QK I+++ + E+ ++E K E+++ + R+L +L +++E
Sbjct: 1093 SKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLE 1152
Query: 971 TS---------------------HNQCQELKARYERATSETKTKHE-------EILQNLQ 1002
+ +E ++E + + KH E + NLQ
Sbjct: 1153 EAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQ 1212
Query: 1003 KTLLDTEDKLKGAREENSGLLQELEELRK-QADKAKAAQTAEDAMQIMEQMTKEKTETLA 1061
+ E + + E L +E + K +A+ K +T ED + +E +L+
Sbjct: 1213 RVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLS 1272
Query: 1062 SLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQ 1121
L K EL E V +L++SK+ T + ++++ +E K A A
Sbjct: 1273 ELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAH 1332
Query: 1122 KSQ-----------QLSALQEENVKLAEELGRSRDEVTS-HQKLEEERSVLNNQLLEMKK 1169
Q Q QE +L L ++ EV K E + +L E KK
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392
Query: 1170 RESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQT 1229
+ ++ ++D++E+ + +A + ++L+ EV L + A SL + +
Sbjct: 1393 KLAQRLQDSEEQ-------VEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK 1445
Query: 1230 LES--DKVKLELKVKNLELQLKENKRQLSSS---SGNTDTQADEDERAQESQIDFLNSVI 1284
+ DKV E K K +E++ +L +S S + T+ + + A E +D L +V
Sbjct: 1446 KQRNFDKVLAEWKTK-----CEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV- 1499
Query: 1285 VDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKK 1327
+R+N++L+ ++ ++E + NG ++ + ++ + +K
Sbjct: 1500 ---KRENKNLEQEIADLTE-QIAENGKTIHELEKSRKQIELEK 1538
Score = 102 bits (255), Expect = 2e-21
Identities = 106/540 (19%), Positives = 245/540 (45%), Gaps = 47/540 (8%)
Query: 347 ISGTTALQEALKEKQQHIEQLLAERDLE----RAEVAKATSHVGEIEQELALARDGHDQH 402
+ +L AL +KQ++ +++LAE + +AE+ + + EL ++ +++
Sbjct: 1433 VERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEA 1492
Query: 403 VLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLEVATVSE 462
+ +LE + + + ++E +L Q+ E + + +L+ ++ + K D+++A
Sbjct: 1493 LDQLETVKRENKNL----EQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALE-- 1546
Query: 463 KSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQR 522
E + AL +E LR +LE + ++D ++I+ E++E + ++QR
Sbjct: 1547 -------EAEAALEHEEAKILRIQLELTQVKSEID------RKIAEKDEEIEQLKRNYQR 1593
Query: 523 EITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLE 582
+ +++ A + + I+ +K+ + ++ +L HAN++ ++ +
Sbjct: 1594 TVETMQSALDAEVRSRNEAIRL----KKKMEGDLNEIEIQLSHANRQAAETLK------- 1642
Query: 583 TAIASHQQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQ-NQQDSERAA 641
+ S Q +++ ++ L + + E +E+ Q E+E L+ + +ERA
Sbjct: 1643 -HLRSVQGQLKDTQLHLDDALRGQE-DLKEQLAIVERRANLLQAEVEELRATLEQTERAR 1700
Query: 642 HAKEMEALRA-KLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELE 700
E E L + + ++++ + SL + KL+ Q E+ED + AE K K+
Sbjct: 1701 KLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760
Query: 701 VLQAKCNEQTKVIDNFTSQLKATEEKLLDL--DALRKASSEGKSEMKKLRQQLEAAEKQI 758
A E+ K + ++ L+ ++ L D + + +K ++Q++ E +I
Sbjct: 1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820
Query: 759 KHLEIEKNAESSKASSITRELQGRELKLTNL-------QENLSEVSQVKETLEKELQILK 811
+ LE E E K + + L+ E ++ L ++N+ + + + L+ +++ K
Sbjct: 1821 RELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYK 1880
Query: 812 EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871
+ EA E+A + ++ ++L + EE+ ++ S + KLR D + E EE
Sbjct: 1881 RQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTRDFTSSRMVVHESEE 1940
Score = 52.0 bits (123), Expect = 4e-06
Identities = 64/283 (22%), Positives = 115/283 (40%), Gaps = 38/283 (13%)
Query: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081
L +++ L K A+ K T ++ Q KT+ D L
Sbjct: 833 LFFKIKPLLKSAETEKEMATMKEEFQ--------KTK-------------------DELA 865
Query: 1082 ENNLKNVEELNKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELG 1141
++ K E K L+ +N + + E E L A + Q + A + K+ E
Sbjct: 866 KSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE 925
Query: 1142 RSRDEVTSHQKLEEERSVLNNQLLEMKKRESKF---IKDADEEKASLQKSISITSALLTE 1198
R+ DE + +L ++ L ++ E+KK + ++EK + + + + L+
Sbjct: 926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSG 985
Query: 1199 KDAELEKLRNEVTVLRGENASA----KSLHSVVQTLESDKVKLELKVKNLELQLKENKRQ 1254
D + KL E L+ + A ++ V +L K KLE +V++LE L++ K+
Sbjct: 986 LDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKL 1045
Query: 1255 LSSSSGNTDTQADEDERAQESQIDFLNSVIVDLQRKNQDLKMK 1297
N + + AQES +D N D Q+ ++ LK K
Sbjct: 1046 RVDLERNKRKLEGDLKLAQESILDLEN----DKQQLDERLKKK 1084
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.122 0.316
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,375,311
Number of Sequences: 37866
Number of extensions: 2174436
Number of successful extensions: 41438
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 765
Number of HSP's successfully gapped in prelim test: 1689
Number of HSP's that attempted gapping in prelim test: 12105
Number of HSP's gapped (non-prelim): 11865
length of query: 1392
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1277
effective length of database: 13,892,928
effective search space: 17741269056
effective search space used: 17741269056
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.