Search of human proteins with 34098959

Search of human proteins with 34098959

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide
1 [Homo sapiens]
         (544 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...  1112   0.0  
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   378   e-105
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   353   2e-97
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   350   2e-96
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   315   7e-86
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   312   6e-85
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   311   1e-84
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   310   2e-84
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   310   2e-84
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   308   6e-84
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   306   2e-83
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   303   2e-82
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   302   6e-82
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   287   2e-77
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   285   7e-77
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   283   3e-76
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   271   1e-72
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   271   1e-72
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   264   1e-70
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   260   2e-69
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   256   5e-68
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   247   2e-65
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  220   3e-57
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   205   8e-53
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   183   4e-46
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   136   4e-32
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   124   3e-28
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   122   6e-28
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   121   2e-27
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   118   1e-26

>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score = 1112 bits (2876), Expect = 0.0
 Identities = 544/544 (100%), Positives = 544/544 (100%)

Query: 1   MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 60
           MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP
Sbjct: 1   MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIP 60

Query: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120
           PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF
Sbjct: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120

Query: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKF 180
           FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKF
Sbjct: 121 FIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKF 180

Query: 181 SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR 240
           SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR
Sbjct: 181 SHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQR 240

Query: 241 FDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKK 300
           FDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKK
Sbjct: 241 FDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKK 300

Query: 301 IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS 360
           IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS
Sbjct: 301 IIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNS 360

Query: 361 LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA 420
           LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA
Sbjct: 361 LLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLA 420

Query: 421 IPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480
           IPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF
Sbjct: 421 IPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETF 480

Query: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNIT 540
           IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNIT
Sbjct: 481 IPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNIT 540

Query: 541 ISRR 544
           ISRR
Sbjct: 541 ISRR 544


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  378 bits (971), Expect = e-105
 Identities = 210/526 (39%), Positives = 307/526 (58%), Gaps = 27/526 (5%)

Query: 19  RLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLP 78
           +L RA  G   L   GGAL L  L AL     L++RR  G PPGP   P +GN   +   
Sbjct: 3   KLWRAEEGAAAL---GGALFLL-LFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAAS 58

Query: 79  PFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVRE 138
             L                     P V +   ++VYG IFS  +G    VVL+ +  V+E
Sbjct: 59  SEL---------------------PHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKE 97

Query: 139 ALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPK 198
            LV Q+E+F+DRP +PL   +TK  G++ + YG  W   R+ + ++ R+FG G+ S E K
Sbjct: 98  CLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESK 157

Query: 199 IIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRG 258
           I+EE K+    ++ +   PF    +I+NAVSNI   + FG+RF Y +++F+ M+   S  
Sbjct: 158 ILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSEN 217

Query: 259 LEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFI 318
           +E+  ++ V L N  PW+  LPFG  ++L +    +  FL ++I+    +   + PQ F+
Sbjct: 218 VELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFV 277

Query: 319 DMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKV 378
           D YL  M++  KN+ +S+F +E L + +G+L IAGT+TTTN L W +L+M+L P++Q +V
Sbjct: 278 DAYLDEMDQG-KNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQV 336

Query: 379 HEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPK 438
            +EI+ ++G N  PS  DK +MPYTEA + EV R   +VPL I H TSE+ V++GY+IPK
Sbjct: 337 QKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPK 396

Query: 439 GTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKM 498
           GT ++ NL+SVH D   W  PE F+P RFLD  G   KKE  +PF +G+R C+GE LA+M
Sbjct: 397 GTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARM 456

Query: 499 ELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR 544
           E+FL F +L+Q F    P +   P L  R G+TL P P+ I   RR
Sbjct: 457 EMFLFFTALLQRFHLHFPHE-LVPDLKPRLGMTLQPQPYLICAERR 501


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  353 bits (906), Expect = 2e-97
 Identities = 199/498 (39%), Positives = 294/498 (59%), Gaps = 28/498 (5%)

Query: 38  LLCGLVA-LLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96
           LL G VA LL   +L+RRR +  PPGP   P +GNF       FL               
Sbjct: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNF-------FL------------VDF 61

Query: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156
           + S +  Q+ +    + YG++FS  +G    V+++    ++EAL+   + F +RP  P+ 
Sbjct: 62  EQSHLEVQLFV----KKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMR 117

Query: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216
             + K+ G++ +  G  W++QR+F+ + LR+FGLGK SLE +I EE +++   +++    
Sbjct: 118 EHIFKKNGLIMSS-GQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQ 176

Query: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276
           PF P   I+NAVSNIICS+ FG+RF+Y +S F+++L  +     +  +    L N+ PW+
Sbjct: 177 PFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWI 236

Query: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336
                GP + L    K +  F+  +I  H++  +    +DFID YL  M +    N  SS
Sbjct: 237 MKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHT-GNPTSS 295

Query: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396
           F EE L     DLF AGT+TT+ +L W LLYM+L P++QEKV  EI+RVIG  + PS   
Sbjct: 296 FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAA 355

Query: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456
           +  MPYT A I EVQR+  ++PL +P   + +T L GY +PKGT+IL NL ++HRDP  W
Sbjct: 356 RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEW 415

Query: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516
             P+ F P+ FL++ GQ  K+E F+PF IGKR C+GEQLA+ ELF+ F SLMQ F F  P
Sbjct: 416 ATPDTFNPDHFLEN-GQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFR-P 473

Query: 517 EDSKKPLLTGRFGLTLAP 534
            +++K  L  R G+T++P
Sbjct: 474 PNNEKLSLKFRMGITISP 491


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  350 bits (897), Expect = 2e-96
 Identities = 206/519 (39%), Positives = 290/519 (55%), Gaps = 31/519 (5%)

Query: 25  LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84
           +GL  L P   A+++   + L+     R+R A   PPGP P P +GN  HV         
Sbjct: 1   MGLEALVPL--AVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHV--------- 49

Query: 85  SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144
                                    L R +G +FS  +    VVVL+   +VREALV   
Sbjct: 50  --------------DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHG 95

Query: 145 EVFSDRPRVPLISIV---TKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIE 201
           E  +DRP VP+  I+    + +GV  A YGP WR+QR+FS STLR+ GLGK SLE  + E
Sbjct: 96  EDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTE 155

Query: 202 EFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI 261
           E   + A    H   PF P  ++  AVSN+I SL  G+RF+Y +  F ++L     GL+ 
Sbjct: 156 EAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKE 215

Query: 262 CLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLD-RENPQDFIDM 320
                  ++N  P L ++P    K LR  +K   + L +++ +H+ + D  + P+D  + 
Sbjct: 216 ESGFLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEA 274

Query: 321 YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHE 380
           +L  ME+  K N  SSF++E L  ++ DLF AG  TT+ +L W LL M L+PDVQ +V +
Sbjct: 275 FLAEMEKA-KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQ 333

Query: 381 EIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGT 440
           EI+ VIG  R P + D+A MPYT A I EVQR   +VPL + HMTS +  +QG+ IPKGT
Sbjct: 334 EIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGT 393

Query: 441 LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMEL 500
            ++ NL SV +D A+WEKP  F+P  FLD QG  +K E F+PF  G+R C+GE LA+MEL
Sbjct: 394 TLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMEL 453

Query: 501 FLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNI 539
           FL F SL+Q F+F++P    +P   G F   + P P+ +
Sbjct: 454 FLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYEL 492


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  315 bits (807), Expect = 7e-86
 Identities = 184/477 (38%), Positives = 279/477 (58%), Gaps = 29/477 (6%)

Query: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           L+LC L  LL  S  R+   RG +PPGPTP P++GN   + +    +             
Sbjct: 7   LVLC-LSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKS------------ 53

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                      L +L++VYG +F+ + G   +VVL  + +V+EAL+   E FS R   PL
Sbjct: 54  -----------LTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPL 102

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215
                +  G+VF++ G  W++ R+FS  TLR+FG+GK S+E ++ EE + +  E++K   
Sbjct: 103 AERANRGFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKA 161

Query: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLV-NICP 274
            P  P  I+  A  N+ICS+ F +RFDY + +F  ++  ++  ++I  +  + +  N  P
Sbjct: 162 SPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSP 221

Query: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
            + Y P G   +L +    + S++ + +K+HQES+D  NPQDFID +L+ ME+E K+N  
Sbjct: 222 IIDYFP-GTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKE-KHNQP 279

Query: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394
           S F  E L     DLF AGT+TT+ +L + LL +  +P+V  KV EEIERVIG NR+P +
Sbjct: 280 SEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339

Query: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454
            D++ MPYT+A + EVQR   ++P ++PH  + +   + Y IPKGT IL +L SV  D  
Sbjct: 340 QDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNK 399

Query: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
            +  PE F P+ FLD+ G   K + F+PF  GKR+C+GE LA MELFL   S++Q+F
Sbjct: 400 EFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNF 456


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  312 bits (799), Expect = 6e-85
 Identities = 193/491 (39%), Positives = 275/491 (56%), Gaps = 39/491 (7%)

Query: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           LL C  V +L   W R+R++RG +PPGPTP P +GN+  +           +S R     
Sbjct: 11  LLACLTVMVLMSVW-RQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER----- 64

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                             YG +F+  +G   VVVL    +V+EALV QAE FS R     
Sbjct: 65  ------------------YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQAT 106

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHG 214
              + K  GV F++ G   +Q R+FS +TLR FG+GK  +E +I EE  + + A    HG
Sbjct: 107 FDWLFKGYGVAFSN-GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHG 165

Query: 215 EDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-C 273
            +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +  
Sbjct: 166 AN-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFS 224

Query: 274 PWLYYLPFGP----FKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEER 329
             + +LP GP    FKEL+ +E     F+ K ++ +Q +LD  +P+DFID +L+ M+EE 
Sbjct: 225 SVMKHLP-GPQQQAFKELQGLE----DFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE 279

Query: 330 KNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGAN 389
           KN  N+ F  + L     +LF AGT+T + +L +  L +  +P+V+ KVHEEI+RVIG N
Sbjct: 280 KN-PNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKN 338

Query: 390 RAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSV 449
           R P   D+A+MPYTEA I E+QR   ++P+ + H  +++T  + + +PKGT + P L SV
Sbjct: 339 RQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSV 398

Query: 450 HRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQ 509
            RDP  +  P DF P  FLD +GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ
Sbjct: 399 LRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQ 458

Query: 510 SFAFALPEDSK 520
           +F F  P+  K
Sbjct: 459 NFRFKSPQSPK 469


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  311 bits (797), Expect = 1e-84
 Identities = 192/509 (37%), Positives = 281/509 (55%), Gaps = 30/509 (5%)

Query: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           ALL C  V +L   W +R+    +PPGPTP P +GN+                 +     
Sbjct: 10  ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNY----------------LQLNTEH 53

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
           I  S++         +  YG +F+  +G   VVVL    +VREALV QAE FS R     
Sbjct: 54  ICDSIM-------KFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQAT 106

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHG 214
              V K  GV F++ G   +Q  +F+ +TLR FG+GK  +E +I EE  + ++A    HG
Sbjct: 107 FDWVFKGYGVAFSN-GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHG 165

Query: 215 EDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-C 273
            +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +  
Sbjct: 166 AN-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFS 224

Query: 274 PWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNS 333
             + +LP GP ++  ++ + +  F+ K ++ +Q +LD  +PQDFID +L+HM+EE KN  
Sbjct: 225 SVMKHLP-GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKN-P 282

Query: 334 NSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPS 393
           N+ F  + L     +LFIAGT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P 
Sbjct: 283 NTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPK 342

Query: 394 LTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDP 453
             D+ +MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP
Sbjct: 343 FEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDP 402

Query: 454 AIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAF 513
           + +  P+DF P  FLDD+GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F  
Sbjct: 403 SFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL 462

Query: 514 ALPEDSKKPLLTGRFGLTLAPHPFNITIS 542
                S K +      +  A  P N T+S
Sbjct: 463 K-SSQSPKDIDVSPKHVVFATIPRNYTMS 490


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  310 bits (795), Expect = 2e-84
 Identities = 184/486 (37%), Positives = 271/486 (55%), Gaps = 27/486 (5%)

Query: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           ALL+C  V +L   W +R+    +PPGPTP P +GN+  +           +S R     
Sbjct: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER----- 64

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                             YG +F+  +G   VVVL    +VREALV QAE FS R     
Sbjct: 65  ------------------YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQAT 106

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215
              V K  GVVF++ G   +Q R+FS +TLR FG+GK  +E +I EE  ++   ++  G 
Sbjct: 107 FDWVFKGYGVVFSN-GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGG 165

Query: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-CP 274
               P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +   
Sbjct: 166 ANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSS 225

Query: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
            + +LP GP ++  Q+ + +  F+ K ++ +Q +LD  +P+DFID +L+ M+EE KN  N
Sbjct: 226 VMKHLP-GPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKN-PN 283

Query: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394
           + F  + L     +LFI GT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P  
Sbjct: 284 TEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 343

Query: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454
            D+A+MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP+
Sbjct: 344 EDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPS 403

Query: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514
            +  P+DF P  FL+++GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F   
Sbjct: 404 FFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463

Query: 515 LPEDSK 520
             +  K
Sbjct: 464 SSQSPK 469


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  310 bits (794), Expect = 2e-84
 Identities = 172/484 (35%), Positives = 270/484 (55%), Gaps = 25/484 (5%)

Query: 37  LLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96
           L+LC    LL   W +  R R +PPGPTP P++GN   + +    +              
Sbjct: 7   LVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKS------------- 53

Query: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156
                       + ++VYG +F+ + G   +VV   + +V+EAL+   E FS R   P+ 
Sbjct: 54  ----------FTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPIS 103

Query: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216
             +TK  G++ ++ G  W++ R+FS +TLR+FG+GK S+E ++ EE   +  E++K    
Sbjct: 104 QRITKGLGIISSN-GKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKAS 162

Query: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276
           P  P  I+  A  N+ICS+ F +RFDY +  F  ++   +    I  +  + + N  P L
Sbjct: 163 PCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLL 222

Query: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336
                G   ++ +      S++++ +K+HQ SLD  NP+DFID +L+ ME+E K+N  S 
Sbjct: 223 IDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQE-KDNQKSE 281

Query: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396
           F+ E L   + DLF+AGT+TT+ +L + LL +  +P+V  KV EEI+ VIG +R+P + D
Sbjct: 282 FNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQD 341

Query: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456
           ++ MPYT+A + E+QR + +VP  +PH  + +T  + Y IPKGT I+  L SV  D   +
Sbjct: 342 RSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEF 401

Query: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516
             P  F P  FLD  G   K + F+PF  GKR+C GE LA+MELFL   +++Q+F     
Sbjct: 402 PNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSV 461

Query: 517 EDSK 520
           +D K
Sbjct: 462 DDLK 465


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  308 bits (790), Expect = 6e-84
 Identities = 181/477 (37%), Positives = 270/477 (56%), Gaps = 29/477 (6%)

Query: 37  LLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           L+LC L  LL  S  R+   RG +PPGPTP P++GN   + +    +             
Sbjct: 7   LVLC-LSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKS------------ 53

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                      L +L+++YG +F+ + G   +VVL  +  V+EAL+   E FS R   PL
Sbjct: 54  -----------LTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPL 102

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215
                +  G+VF++ G  W++ R+FS  TLR+FG+GK S+E ++ EE + +  E++K   
Sbjct: 103 AERANRGFGIVFSN-GKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKA 161

Query: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPW 275
            P  P  I+  A  N+ICS+ F +RFDY + +F  ++  ++  + I     + + N  P 
Sbjct: 162 SPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPT 221

Query: 276 LY-YLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
           +  Y P    K L+ +    +  L+K+ K+HQES+D  NP+DFID +L+ ME+E K N  
Sbjct: 222 IIDYFPGTHNKLLKNLAFMESDILEKV-KEHQESMDINNPRDFIDCFLIKMEKE-KQNQQ 279

Query: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394
           S F  E L     DL  AGT+TT+ +L + LL +  +P+V  KV EEIERVIG NR+P +
Sbjct: 280 SEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM 339

Query: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454
            D+  MPYT+A + EVQR   ++P ++PH  + +   + Y IPKGT IL +L SV  D  
Sbjct: 340 QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNK 399

Query: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
            +  PE F P  FLD+ G   K   F+PF  GKR+C+GE LA+MELFL    ++Q+F
Sbjct: 400 EFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNF 456


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  306 bits (785), Expect = 2e-83
 Identities = 176/463 (38%), Positives = 270/463 (58%), Gaps = 35/463 (7%)

Query: 59  IPPGPTPWPLVGNFGHV----LLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVY 114
           +PPGP P PL+GN   +    LL  FLR R                             Y
Sbjct: 30  LPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE---------------------------KY 62

Query: 115 GSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVW 174
           G +F+  +G   VV+L    ++REALV +AE FS R ++ ++    +  GV+FA+ G  W
Sbjct: 63  GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN-GNRW 121

Query: 175 RQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICS 234
           +  R+FS +T+R FG+GK S+E +I EE + +  E++K       P  +  +  +NIICS
Sbjct: 122 KVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICS 181

Query: 235 LCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP-WLYYLPFGPFKELRQIEKD 293
           + FG+RF Y + EF KML    +   +  +    L  +   +L Y P G  +++ +  ++
Sbjct: 182 IVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFP-GAHRQVYKNLQE 240

Query: 294 ITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAG 353
           I +++   ++ H+E+LD   P+D ID YLLHME+E K+N++S F  + L      LF AG
Sbjct: 241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKE-KSNAHSEFSHQNLNLNTLSLFFAG 299

Query: 354 TDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRL 413
           T+TT+ +L +  L M   P V E+V+ EIE+VIG +R P L D+A+MPYTEA I E+QR 
Sbjct: 300 TETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRF 359

Query: 414 TVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQ 473
           + ++P+ +PH+ +++T  +GY IPK T +   L +   DP  +EKP+ F P+ FLD  G 
Sbjct: 360 SDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGA 419

Query: 474 LIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALP 516
           L K E FIPF +GKR+C+GE +A+ ELFL F +++Q+F+ A P
Sbjct: 420 LKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASP 462


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  303 bits (777), Expect = 2e-82
 Identities = 190/511 (37%), Positives = 279/511 (54%), Gaps = 32/511 (6%)

Query: 37  LLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGI 96
           LLL  LV LL    L  R    +PPGP P  ++GN   +LL   L  +  L+S T+    
Sbjct: 10  LLLLALVCLL--LTLSSRDKGKLPPGPRPLSILGN---LLL---LCSQDMLTSLTK---- 57

Query: 97  DPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLI 156
                        L++ YGS+++  +G   VVVLS + +V+EALV Q E FS R   P  
Sbjct: 58  -------------LSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAF 104

Query: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGED 216
              TK  G+ F+  G  W+  R+FS   LR+FG+GK S+E +I+EE  ++ AE++K   +
Sbjct: 105 FNFTKGNGIAFSS-GDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGE 163

Query: 217 PFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWL 276
           PF P  ++S +VSNIICS+ FG RFDY +     ++  ++   +I  +    L +I P L
Sbjct: 164 PFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSL 223

Query: 277 YYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS 336
                GP + + Q  K +   +   + DHQ SLD  +P+DFI  +L  M EE K +  S 
Sbjct: 224 LDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEE-KEDPLSH 282

Query: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396
           F  + L     +L   GT T + +L    L +   P VQ +V EEI+ V+G  R P+L D
Sbjct: 283 FHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKD 342

Query: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456
           +A MPYT+A I EVQR   ++P+ +PH  + +T  +G+ IPKGT ++  L +VH DP+ +
Sbjct: 343 RAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQF 402

Query: 457 EKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFA---F 513
             P++F P  FLD      K   F+PF  G+R+C+GE LA+MELFL   +++QSF+    
Sbjct: 403 LTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPL 462

Query: 514 ALPEDSKKPLLTGRFGLTLAPHPFNITISRR 544
             PED     L+   GL   P PF + +  R
Sbjct: 463 GAPEDIDLTPLSS--GLGNLPRPFQLCLRPR 491


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  302 bits (773), Expect = 6e-82
 Identities = 182/493 (36%), Positives = 275/493 (55%), Gaps = 30/493 (6%)

Query: 30  LDPSGGALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLS 88
           +DP+  AL+LC L  L   S  R+   RG +P GPTP P++GN                 
Sbjct: 1   MDPAV-ALVLC-LSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNI---------------- 42

Query: 89  SRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFS 148
                  +   V      L + ++VYG +F+ + G   +VVL  + +V+EAL+   E FS
Sbjct: 43  -------LQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFS 95

Query: 149 DRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKA 208
            R   P+   V K  G++F++ G  W++ R+F   TLR+FG+GK S+E ++ EE + +  
Sbjct: 96  GRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVE 154

Query: 209 EMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVL 268
           E++K    P  P  I+  A  N+ICS+ F  RFDY +  F  ++   +  L I  +  + 
Sbjct: 155 ELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQ 214

Query: 269 LVNICPWLY-YLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEE 327
           + N  P L  YLP G   ++ +    I S++ + IK+HQESLD  + +DFID +L+ ME+
Sbjct: 215 VCNNFPALIDYLP-GSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQ 273

Query: 328 ERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIG 387
           E K+N  S F  E L   + D+F AGT+TT+ +L + LL +   P+V  KV EEIE V+G
Sbjct: 274 E-KHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVG 332

Query: 388 ANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLW 447
            NR+P + D++ MPYT+A + E+QR   ++P  +PH  + +   + Y IPKGT I+ +L 
Sbjct: 333 RNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT 392

Query: 448 SVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSL 507
           SV  +   +  PE F P  FLD  G   K + F+PF  GKR+CMGE LA+MELFL   ++
Sbjct: 393 SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTI 452

Query: 508 MQSFAFALPEDSK 520
           +Q+F      D K
Sbjct: 453 LQNFNLKSQVDPK 465


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  287 bits (734), Expect = 2e-77
 Identities = 159/477 (33%), Positives = 271/477 (56%), Gaps = 28/477 (5%)

Query: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           ALL+     LL   W +   +  +PPGP P P++GN   + L      ++   S TR   
Sbjct: 9   ALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLEL------KNIPKSFTR--- 59

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                         LA+ +G +F+ ++G   +VV+  + +V+EAL+   + FS R  +P 
Sbjct: 60  --------------LAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPA 105

Query: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215
                +++G++F + GP W+  R+FS +TLR++G+GK   E +I  E  ++   ++K   
Sbjct: 106 FH-AHRDRGIIFNN-GPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQG 163

Query: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP- 274
            PF P  +I  A  N+I  + F + FDY + +F +++   +    +     + L N  P 
Sbjct: 164 QPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPS 223

Query: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
           +L+YLP    K ++ +  ++  ++ + +K+H +SLD   P+D  D  L+ ME+E K+++ 
Sbjct: 224 FLHYLPGSHRKVIKNVA-EVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE-KHSAE 281

Query: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394
             +  + +   + DLF AGT+TT+ +L + LL +   P+++EK+HEEI+RVIG +R P++
Sbjct: 282 RLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAI 341

Query: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454
            D+ +MPY +A + E+QR   +VP  +PH  + +T+ +GY IPKGT+++P L SV  D  
Sbjct: 342 KDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQ 401

Query: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSF 511
            +  PE F P  FL++ G+    + F PF  GKRVC GE LA+MELFL+  +++Q F
Sbjct: 402 EFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHF 458


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  285 bits (729), Expect = 7e-77
 Identities = 186/502 (37%), Positives = 269/502 (53%), Gaps = 32/502 (6%)

Query: 36  ALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAA 94
           ALLL   + LL    L   RARG +PPGPTP PL+GN         LR  +  S      
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQ------LRPGALYSG----- 56

Query: 95  GIDPSVIGPQVLLAHLARVYGSIFSFFIGHYL-VVVLSDFHSVREALVQQAEVFSDRPRV 153
                       L  L++ YG +F+ ++G +  VVVL    +VREAL  QAE FS R  V
Sbjct: 57  ------------LMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTV 104

Query: 154 PLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKH 213
            ++       GV F++ G  WRQ RKF+   LR  G+GK   E  I  E + +    Q  
Sbjct: 105 AMLEGTFDGHGVFFSN-GERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGT 163

Query: 214 GEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNIC 273
              PF P  +++ A SN++CSL FG RF Y + EF+ ++      L    +       + 
Sbjct: 164 EGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMF 223

Query: 274 PWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENP-QDFIDMYLLHMEEERKNN 332
            W      GP K+L      + +F  + ++ HQ +LD   P +D +D +LL M +E +N 
Sbjct: 224 SWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNP 283

Query: 333 SNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAP 392
                ++  L  +I  LF AGT T + ++ + LL +   P VQ+ V EE+ R +GA +AP
Sbjct: 284 GTEFTNKNMLMTVIYLLF-AGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAP 342

Query: 393 SLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRD 452
           SL D+ ++PYT+A + E QRL  +VP+ IP      T  +GYT+P+GT + P L S+  D
Sbjct: 343 SLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHD 402

Query: 453 PAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFA 512
           P I++ PE+F P+RFLD  G+  K E F+PF +GKRVC+GE LAK ELFL F +++Q+F+
Sbjct: 403 PNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS 462

Query: 513 FALP----EDSKKPLLTGRFGL 530
              P      S KP ++G F +
Sbjct: 463 LESPCPPDTLSLKPTVSGLFNI 484


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  283 bits (724), Expect = 3e-76
 Identities = 183/516 (35%), Positives = 262/516 (50%), Gaps = 76/516 (14%)

Query: 25  LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84
           +GL  L P   A+++   + L+     R+R A   PPGP P P +GN  HV         
Sbjct: 1   MGLEALVPL--AVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHV--------- 49

Query: 85  SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144
                                    L R +G +FS  +    VVVL+   +VREALV   
Sbjct: 50  --------------DFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHG 95

Query: 145 EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFK 204
           E  +DRP VP+  I+          +GP  R Q +                         
Sbjct: 96  EDTADRPPVPITQILG---------FGP--RSQGR------------------------- 119

Query: 205 YVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLN 264
                       PF P  ++  AVSN+I SL  G+RF+Y +  F ++L     GL+    
Sbjct: 120 ------------PFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG 167

Query: 265 SQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLD-RENPQDFIDMYLL 323
               ++N  P L ++P    K LR  +K   + L +++ +H+ + D  + P+D  + +L 
Sbjct: 168 FLREVLNAVPVLLHIPALAGKVLR-FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLA 226

Query: 324 HMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIE 383
            ME+  K N  SSF++E L  ++ DLF AG  TT+ +L W LL M L+PDVQ +V +EI+
Sbjct: 227 EMEKA-KGNPESSFNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEID 285

Query: 384 RVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLIL 443
            VIG  R P + D+A MPYT A I EVQR   +VPL + HMTS +  +QG+ IPKGT ++
Sbjct: 286 DVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLI 345

Query: 444 PNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLM 503
            NL SV +D A+WEKP  F+P  FLD QG  +K E F+PF  G+R C+GE LA+MELFL 
Sbjct: 346 TNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLF 405

Query: 504 FVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNI 539
           F SL+Q F+F++P    +P   G F   + P P+ +
Sbjct: 406 FTSLLQHFSFSVPTGQPRPSHHGVFAFLVTPSPYEL 441


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  271 bits (693), Expect = 1e-72
 Identities = 154/488 (31%), Positives = 264/488 (54%), Gaps = 44/488 (9%)

Query: 60  PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIG--PQVLLAHLARVYGSI 117
           PPGP  WPL+   GH+L                        +G  P + L+ +++ YG +
Sbjct: 40  PPGPWGWPLI---GHML-----------------------TLGKNPHLALSRMSQQYGDV 73

Query: 118 FSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFA-HYGPVWRQ 176
               IG   VVVLS   ++R+ALV+Q + F  RP +   ++++  + + F+   GPVW  
Sbjct: 74  LQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAA 133

Query: 177 QRKFSHSTLRHFGLG-------KLSLEPKIIEEFKYVKAEMQK--HGEDPFCPFSIISNA 227
           +R+ + + L+ F +           LE  + +E + + + +Q+   G   F P+  +  +
Sbjct: 134 RRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVS 193

Query: 228 VSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKEL 287
           V+N+IC++CFG+R+D+ + E   ++   +   E+  +      +  P L YLP       
Sbjct: 194 VTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNP--ADFIPILRYLPNPSLNAF 251

Query: 288 RQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEER-KNNSNSSFDEEYLFYII 346
           + + +   SF++K++K+H ++ ++ + +D  D  + H +E++   N+N    +E +  I+
Sbjct: 252 KDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIV 311

Query: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406
            DLF AG DT T ++ W L+Y+ +NP VQ K+ EE++ VIG +R P L+D++ +PY EA 
Sbjct: 312 LDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAF 371

Query: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466
           I+E  R +  VP  IPH T+ +T L+G+ IPKG  +  N W ++ D  +W  P +F P R
Sbjct: 372 ILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPER 431

Query: 467 FLDDQGQLIK--KETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLL 524
           FL   G + K   E  I FG+GKR C+GE +A+ E+FL    L+Q   F++P   K   +
Sbjct: 432 FLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVD-M 490

Query: 525 TGRFGLTL 532
           T  +GLT+
Sbjct: 491 TPIYGLTM 498


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  271 bits (692), Expect = 1e-72
 Identities = 167/510 (32%), Positives = 267/510 (52%), Gaps = 46/510 (9%)

Query: 52  RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLA 111
           RRR+ R  PPGP  WPL+GN                     AA +  +     +  A LA
Sbjct: 43  RRRQLRSAPPGPFAWPLIGN---------------------AAAVGQAA---HLSFARLA 78

Query: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYG 171
           R YG +F   +G   +VVL+   ++ +ALVQQ   F+DRP      +V+  + + F HY 
Sbjct: 79  RRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYS 138

Query: 172 PVWRQQRKFSHSTLRHFGL----GKLSLEPKIIEEFKYVKAEMQKHGEDP--FCPFSIIS 225
             W+ QR+ +HS +R+F       +  LE  ++ E + + A + +   D     P  +  
Sbjct: 139 EHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198

Query: 226 NAVSNIICSLCFGQRFDYTNSEFKKMLGFMSR-GLEICLNSQVLLVNICPWLYYLPFGP- 283
            AV+N++ ++CFG R+ + + EF+++L      G  +   S   LV++ PWL Y P  P 
Sbjct: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGS---LVDVMPWLQYFP-NPV 254

Query: 284 ---FKELRQIEKDITSFLKKIIKDHQESL-DRENPQDFIDMYLLHMEEERKNNSNSS--- 336
              F+E  Q+ ++ ++F+      H ESL     P+D +D ++L  E++   +S+     
Sbjct: 255 RTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314

Query: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396
            D E +   I D+F A  DT + +L W LL  +  PDVQ +V  E+++V+G +R P + D
Sbjct: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374

Query: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456
           +  +PY  A + E  R +  VP+ IPH T+ NT + GY IPK T++  N WSV+ DP  W
Sbjct: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434

Query: 457 EKPEDFYPNRFLDDQGQLIKKET--FIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514
             PE+F P RFLD  G + K  T   + F +GKR C+GE+L+KM+LFL F+S++      
Sbjct: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFL-FISILAHQCDF 493

Query: 515 LPEDSKKPLLTGRFGLTLAPHPFNITISRR 544
               ++   +   +GLT+ P  F + ++ R
Sbjct: 494 RANPNEPAKMNFSYGLTIKPKSFKVNVTLR 523


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  264 bits (675), Expect = 1e-70
 Identities = 153/388 (39%), Positives = 230/388 (59%), Gaps = 7/388 (1%)

Query: 157 SIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKY-VKAEMQKHGE 215
           SI+   +GV F++ G   +Q  +F+ +TLR FG+GK  +E +I EE  + ++A    HG 
Sbjct: 57  SIMKVSQGVAFSN-GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGA 115

Query: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-CP 274
           +   P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +   
Sbjct: 116 N-IDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSS 174

Query: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
            + +LP GP ++  ++ + +  F+ K ++ +Q +LD  +PQDFID +L+HM+EE KN  N
Sbjct: 175 VMKHLP-GPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKN-PN 232

Query: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394
           + F  + L     +LFIAGT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P  
Sbjct: 233 TEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 292

Query: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454
            D+ +MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP+
Sbjct: 293 EDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPS 352

Query: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514
            +  P+DF P  FLDD+GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F   
Sbjct: 353 FFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 412

Query: 515 LPEDSKKPLLTGRFGLTLAPHPFNITIS 542
               S K +      +  A  P N T+S
Sbjct: 413 -SSQSPKDIDVSPKHVVFATIPRNYTMS 439



 Score = 39.3 bits (90), Expect = 0.009
 Identities = 17/37 (45%), Positives = 23/37 (62%)

Query: 36 ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNF 72
          ALL C  V +L   W +R+    +PPGPTP P +GN+
Sbjct: 10 ALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNY 46


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  260 bits (665), Expect = 2e-69
 Identities = 164/488 (33%), Positives = 260/488 (53%), Gaps = 37/488 (7%)

Query: 36  ALLLCGLVALLG-WSWLRR-----RRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSS 89
           ALLL   + LLG W  L         A   PPGP P PLVGN  H+L          LS 
Sbjct: 2   ALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNL-HLLR---------LSQ 51

Query: 90  RTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSD 149
           + R+             L  L+  YG +F+  +G    VVL+ F +V+EAL    +  +D
Sbjct: 52  QDRS-------------LMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELAD 98

Query: 150 RPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAE 209
           RP + +  ++ +  G+ F+  G  WR  R+F+   L   G+G+  +  KI++E K +  +
Sbjct: 99  RPPIAIFQLIQRGGGIFFSS-GARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQ 157

Query: 210 MQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLL 269
           +  +   PF P +++  A SNI  +L FG+RFDY +  F  +LG +   + +  +  + L
Sbjct: 158 LDGYRGRPF-PLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL 216

Query: 270 VNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQ-DFIDMYLLHMEEE 328
            N+ PWL  L       LR+IE ++ + L+ +++  +  +   +P   ++D  +   ++ 
Sbjct: 217 FNVYPWLGALLQLHRPVLRKIE-EVRAILRTLLEARRPHVCPGDPVCSYVDALI---QQG 272

Query: 329 RKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA 388
           + ++    F E        D+ +AGT+TT+ +L W  L M  +PDVQ +V EE++RV+G 
Sbjct: 273 QGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP 332

Query: 389 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWS 448
            R P L D+  +PYT A + EVQR   ++P  +P  T+ +T L G+ +PKGT ++P L S
Sbjct: 333 GRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTS 391

Query: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508
           V  D   W+ P  F P  FLD  G  +K+E F+PF  G+RVC+GE+LA+ ELFL+F  L+
Sbjct: 392 VLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLL 451

Query: 509 QSFAFALP 516
           Q +    P
Sbjct: 452 QRYRLLPP 459


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  256 bits (653), Expect = 5e-68
 Identities = 160/515 (31%), Positives = 263/515 (51%), Gaps = 49/515 (9%)

Query: 37  LLLCGLVALLGW--SWLRRRRARGI--PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTR 92
           LL   +  L+ W    LR R  +G+  PP P  WPL+   GHVL                
Sbjct: 15  LLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLL---GHVL---------------- 55

Query: 93  AAGIDPSVIG--PQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDR 150
                   +G  P + L+ +++ YG +    IG   V+VLS   ++R+ALV+Q + F  R
Sbjct: 56  -------TLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGR 108

Query: 151 PRVPLISIVTKEKGVVFA-HYGPVWRQQRKFSHSTLRHFGL-------GKLSLEPKIIEE 202
           P +   +++T  + + F+   GPVW  +R+ + + L  F +           LE  + +E
Sbjct: 109 PDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKE 168

Query: 203 FKYVKAEMQK--HGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLE 260
            K + + +Q+   G   F P++ +  +V+N+I ++CFGQ F  ++ E   ++      +E
Sbjct: 169 AKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVE 228

Query: 261 ICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDM 320
              +   L  +  P L YLP    +  +   +    FL+K +++H +  D+ + +D    
Sbjct: 229 TASSGNPL--DFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGA 286

Query: 321 YLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHE 380
              H ++  + + N    +E +  ++ D+F AG DT T ++ W L+Y+   P++Q K+ +
Sbjct: 287 LFKHSKKGPRASGN-LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQK 345

Query: 381 EIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGT 440
           E++ VIG  R P L+D+ Q+PY EA I+E  R +  +P  IPH T+ +T L G+ IPK  
Sbjct: 346 ELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKC 405

Query: 441 LILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKK---ETFIPFGIGKRVCMGEQLAK 497
            +  N W V+ DP +WE P +F P RFL   G  I K   E  + FG+GKR C+GE LAK
Sbjct: 406 CVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAK 465

Query: 498 MELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTL 532
            E+FL    L+Q   F++P   K   LT  +GLT+
Sbjct: 466 WEIFLFLAILLQQLEFSVPPGVKVD-LTPIYGLTM 499


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  247 bits (631), Expect = 2e-65
 Identities = 159/492 (32%), Positives = 240/492 (48%), Gaps = 87/492 (17%)

Query: 30  LDPSGGALLLCGLVALLGWSWLRRRRARG-IPPGPTPWPLVGNFGHVLLPPFLRRRSWLS 88
           +DP+  AL+LC L  L   S  R+   RG +P GPTP P++GN                 
Sbjct: 1   MDPAV-ALVLC-LSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNI---------------- 42

Query: 89  SRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFS 148
                  +   V      L + ++VYG +F+ + G   +VVL  + +V+EAL+   E FS
Sbjct: 43  -------LQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFS 95

Query: 149 DRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKA 208
            R   P+   V K  G++F++ G  W++ R+F   TLR+FG+GK S+E ++ EE + +  
Sbjct: 96  GRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVE 154

Query: 209 EMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVL 268
           E++K    P  P  I+  A  N+ICS+ F  RFDY +  F  ++   +  L I  +    
Sbjct: 155 ELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSS---- 210

Query: 269 LVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEE 328
                PW+                                                   +
Sbjct: 211 -----PWI---------------------------------------------------Q 214

Query: 329 RKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA 388
            K+N  S F  E L   + D+F AGT+TT+ +L + LL +   P+V  KV EEIE V+G 
Sbjct: 215 EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGR 274

Query: 389 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWS 448
           NR+P + D++ MPYT+A + E+QR   ++P  +PH  + +   + Y IPKGT I+ +L S
Sbjct: 275 NRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTS 334

Query: 449 VHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLM 508
           V  +   +  PE F P  FLD  G   K + F+PF  GKR+CMGE LA+MELFL   +++
Sbjct: 335 VLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTIL 394

Query: 509 QSFAFALPEDSK 520
           Q+F      D K
Sbjct: 395 QNFNLKSQVDPK 406


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  220 bits (560), Expect = 3e-57
 Identities = 145/499 (29%), Positives = 249/499 (49%), Gaps = 34/499 (6%)

Query: 38  LLCGLVALLGWSWLRRRRARGI--PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95
           L+  L+  L + +  +RR  G   P      PLVG+       PFL R   + +      
Sbjct: 4   LVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSL------PFLPRHGHMHNN----- 52

Query: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155
                         L + YG I+S  +G    V++      +E L+++ + FS RP++  
Sbjct: 53  -----------FFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMAT 101

Query: 156 ISIVTKE-KGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHG 214
           + I +   KG+ FA  G  W+  R+ + +T   F  G   LE  I +E   +   +  H 
Sbjct: 102 LDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHN 161

Query: 215 EDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICP 274
                    +  AV+N+I  +CF   +   + E   +  + + G+   L S+  LV++ P
Sbjct: 162 GQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY-NEGIIDNL-SKDSLVDLVP 219

Query: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334
           WL   P    ++L+   K     L KI+++++E    ++  + +D  +         N+ 
Sbjct: 220 WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAG 279

Query: 335 SSFDEE-----YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGAN 389
              D E     ++   IGD+F AG +TTT+ + W L ++  NP V++K++EEI++ +G +
Sbjct: 280 PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFS 339

Query: 390 RAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSV 449
           R P+++D+ ++   EATI EV RL  V P+ IPH  + ++ +  + + KGT ++ NLW++
Sbjct: 340 RTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWAL 399

Query: 450 HRDPAIWEKPEDFYPNRFLDDQG-QLIKKE-TFIPFGIGKRVCMGEQLAKMELFLMFVSL 507
           H +   W +P+ F P RFL+  G QLI    +++PFG G R C+GE LA+ ELFL+   L
Sbjct: 400 HHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWL 459

Query: 508 MQSFAFALPEDSKKPLLTG 526
           +Q F   +P+D + P L G
Sbjct: 460 LQRFDLEVPDDGQLPSLEG 478


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  205 bits (522), Expect = 8e-53
 Identities = 151/527 (28%), Positives = 250/527 (47%), Gaps = 53/527 (10%)

Query: 25  LGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRR 84
           LGLL L P     LL G  A L W+W + R    +PP      L   F H+L P      
Sbjct: 4   LGLLLLLP-----LLAG--ARLLWNWWKLRSLH-LPP------LAPGFLHLLQPDL---- 45

Query: 85  SWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQA 144
                               + L  L + +G I+   +G   VVVL+   ++ EA+V++ 
Sbjct: 46  -------------------PIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKW 86

Query: 145 EVFSDRPRVPLISIVTKE-KGVVFAHYGPVWRQQRKFSHSTLRHFGLG-KLSLEPKIIEE 202
             F+ RP      +V++    +    Y  +W+  +K + S L    LG + S+EP + + 
Sbjct: 87  ADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---LGIRDSMEPVVEQL 143

Query: 203 FKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEIC 262
            +     M+     P       S    +IIC L FG +    N         +   L+  
Sbjct: 144 TQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNL-MPAYYKCIQEVLKTW 202

Query: 263 LNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYL 322
            +  + +V++ P+L + P    + L+Q  +     ++  ++ H+ESL     +D +D  L
Sbjct: 203 SHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYML 262

Query: 323 LHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEI 382
             + +      +    E ++     DL I GT+TT N+L W ++++  +P++Q+++ EE+
Sbjct: 263 QGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEEL 322

Query: 383 ERVIGANRAPSLT---DKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKG 439
           +  +G   + S     D+A++P   ATI EV RL  VVPLA+PH T+  + + GY IP+G
Sbjct: 323 DHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEG 382

Query: 440 TLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKME 499
           T+I+PNL   H D  +WE+P +F+P+RFL+      K    + FG G RVC+GE LA++E
Sbjct: 383 TVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLE 438

Query: 500 LFLMFVSLMQSFAFALPEDSKKPLL--TGRFGLTLAPHPFNITISRR 544
           LF++   L+Q+F   LP     P L       + L   PF + +  R
Sbjct: 439 LFVVLTRLLQAFTL-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 484


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  183 bits (464), Expect = 4e-46
 Identities = 114/381 (29%), Positives = 193/381 (50%), Gaps = 15/381 (3%)

Query: 170 YGPVWRQQRKFSHSTLRHFGLG-KLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAV 228
           Y  +W+  +K + S L    LG + S+EP + +  +     M+     P       S   
Sbjct: 83  YSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 139

Query: 229 SNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELR 288
            +IIC L FG +    N         +   L+   +  + +V++ P+L + P    + L+
Sbjct: 140 CSIICYLTFGDKIKDDNL-MPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLK 198

Query: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGD 348
           Q  +     ++  ++ H+ESL     +D +D  L  + +      +    E ++     D
Sbjct: 199 QAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258

Query: 349 LFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLT---DKAQMPYTEA 405
           L I GT+TT N+L W ++++  +P++Q+++ EE++  +G   + S     D+A++P   A
Sbjct: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318

Query: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465
           TI EV RL  VVPLA+PH T+  + + GY IP+GT+I+PNL   H D  +WE+P +F+P+
Sbjct: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378

Query: 466 RFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLL- 524
           RFL+      K    + FG G RVC+GE LA++ELF++   L+Q+F   LP     P L 
Sbjct: 379 RFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQ 433

Query: 525 -TGRFGLTLAPHPFNITISRR 544
                 + L   PF + +  R
Sbjct: 434 PLPHCSVILKMQPFQVRLQPR 454


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  136 bits (343), Expect = 4e-32
 Identities = 122/498 (24%), Positives = 218/498 (43%), Gaps = 54/498 (10%)

Query: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120
           PGPTP P +GN               LS        D              + YG ++ F
Sbjct: 39  PGPTPLPFLGNI--------------LSYHKGFCMFD----------MECHKKYGKVWGF 74

Query: 121 FIGHYLVVVLSDFHSVREALVQQA-EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRK 179
           + G   V+ ++D   ++  LV++   VF++R     +  +   K  +       W++ R 
Sbjct: 75  YDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KSAISIAEDEEWKRLRS 131

Query: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI--ISNAVS-NIICSLC 236
               T   F  GKL     II ++  V     +   +   P ++  +  A S ++I S  
Sbjct: 132 LLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTS 188

Query: 237 FGQRFDYTNS-------EFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQ 289
           FG   D  N+         KK+L F        L+   L + + P+L  +P      +  
Sbjct: 189 FGVNIDSLNNPQDPFVENTKKLLRFDF------LDPFFLSITVFPFL--IPILEVLNICV 240

Query: 290 IEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS---FDEEYLFYII 346
             +++T+FL+K +K  +ES   +  +  +D   L ++ +    + S     D E +   I
Sbjct: 241 FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI 300

Query: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406
             +F AG +TT++ L + +  ++ +PDVQ+K+ EEI+ V+     P+     QM Y +  
Sbjct: 301 IFIF-AGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMV 359

Query: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466
           + E  RL  +  + +  +  ++  + G  IPKG +++   +++HRDP  W +PE F P R
Sbjct: 360 VNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPER 418

Query: 467 FLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTG 526
           F       I    + PFG G R C+G + A M + L  + ++Q+F+F   ++++ PL   
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLS 478

Query: 527 RFGLTLAPHPFNITISRR 544
             GL     P  + +  R
Sbjct: 479 LGGLLQPEKPVVLKVESR 496


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  124 bits (310), Expect = 3e-28
 Identities = 120/492 (24%), Positives = 213/492 (43%), Gaps = 43/492 (8%)

Query: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120
           PGPTP PL+GN               LS R      D              + YG ++  
Sbjct: 39  PGPTPLPLLGNV--------------LSYRQGLWKFDTECY----------KKYGKMWGT 74

Query: 121 FIGHYLVVVLSDFHSVREALVQQA-EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRK 179
           + G   V+ ++D   +R  LV++   VF++R  +  +  +   K  +       W++ R 
Sbjct: 75  YEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFM---KSAISLAEDEEWKRIRS 131

Query: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI--ISNAVS-NIICSLC 236
               T   F  GKL     II ++  V     +   +   P ++  I  A S ++I    
Sbjct: 132 LLSPT---FTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTS 188

Query: 237 FGQRFDYTNSEFKKMLGFMSRGLEI-CLNSQVLLVNICPWLYYLPFGPFKELRQIEKDIT 295
           FG   D  N+     +    + L+   L+   L + + P+L   P      +    KD  
Sbjct: 189 FGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFL--TPVFEALNVSLFPKDTI 246

Query: 296 SFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS---FDEEYLFYIIGDLFIA 352
           +FL K +   ++S   +  +  +D   L ++ +    + S     D E     I  +F A
Sbjct: 247 NFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIF-A 305

Query: 353 GTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQR 412
           G +TT++ L + L  ++ +PDVQ+K+ +EI+ V+     P+     QM Y +  + E  R
Sbjct: 306 GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR 365

Query: 413 LTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQG 472
           L  V  + +     ++  + G  IPKG++++   +++H DP  W +PE+F P RF   + 
Sbjct: 366 LFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERF-SKKK 423

Query: 473 QLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTL 532
             I    + PFG G R C+G + A M + L  + ++Q+F+F   ++++ PL     GL  
Sbjct: 424 DSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ 483

Query: 533 APHPFNITISRR 544
              P  + +  R
Sbjct: 484 PEKPIVLKVDSR 495


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  122 bits (307), Expect = 6e-28
 Identities = 83/298 (27%), Positives = 151/298 (50%), Gaps = 8/298 (2%)

Query: 230 NIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI-CLNSQVLLVNICPWLYYLPFGPFKELR 288
           ++I    FG   D  N+     L  M + L++  L+  +LL+++ P+L   P      + 
Sbjct: 182 DVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL--TPVFEALNIG 239

Query: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMY--LLHMEEERKNNSNSSFDEEYLFYII 346
              KD+T FLK  I+  +ES  ++  +  +D +  ++  +  ++  S+ +  +  L    
Sbjct: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

Query: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK-AQMPYTEA 405
             +  A  DTT+ +L + +  ++ +PDVQ+K+ EEI+ V+  N+AP   D   QM Y + 
Sbjct: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDM 358

Query: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465
            + E  RL  VV   +  +  ++  + G  IPKG  ++  ++++H DP  W +PE F P 
Sbjct: 359 VVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417

Query: 466 RFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPL 523
           RF       I    +IPFG G R C+G + A   + L  +  +Q+F+F   ++++ PL
Sbjct: 418 RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPL 475


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  121 bits (303), Expect = 2e-27
 Identities = 120/498 (24%), Positives = 212/498 (42%), Gaps = 54/498 (10%)

Query: 61  PGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSF 120
           PGPTP P +GN               LS R      D              + Y  ++  
Sbjct: 39  PGPTPLPFLGNA--------------LSFRKGYWTFDMECY----------KKYRKVWGI 74

Query: 121 FIGHYLVVVLSDFHSVREALVQQA-EVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRK 179
           +     ++ ++D   ++  LV++   VF++R     +  +   K  +       W++ R 
Sbjct: 75  YDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFM---KNAISIAEDEEWKRIRS 131

Query: 180 FSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSI--ISNAVS-NIICSLC 236
               T   F  GKL     II ++  V     +   +   P ++  +  A S ++I S  
Sbjct: 132 LLSPT---FTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTS 188

Query: 237 FGQRFDYTNS-------EFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQ 289
           FG   D  N+         KK+L F        L+  VL + + P+L   P      +  
Sbjct: 189 FGVSIDSLNNPQDPFVENTKKLLRFNP------LDPFVLSIKVFPFL--TPILEALNITV 240

Query: 290 IEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSS---FDEEYLFYII 346
             + + SFL K +K  +E   +E  +  +D   L ++ +   +S +     D E +   I
Sbjct: 241 FPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSI 300

Query: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEAT 406
             +F AG +TT++ L + +  ++ +PDVQ+KV +EI+ V+     P+     Q+ Y +  
Sbjct: 301 IFIF-AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMV 359

Query: 407 IMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNR 466
           + E  RL  V  + +  +  ++  + G  IPKG +++   + +H DP  W +PE F P R
Sbjct: 360 VNETLRLFPVA-MRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPER 418

Query: 467 FLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTG 526
           F       I    + PFG G R C+G + A + + L  V ++Q+F+F   ++++ PL   
Sbjct: 419 FSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLR 478

Query: 527 RFGLTLAPHPFNITISRR 544
             GL L   P  +    R
Sbjct: 479 FGGLLLTEKPIVLKAESR 496


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  118 bits (296), Expect = 1e-26
 Identities = 83/299 (27%), Positives = 152/299 (50%), Gaps = 9/299 (3%)

Query: 230 NIICSLCFGQRFDYTNSEFKKMLGFMSRGLEI-CLNSQVLLVNICPWLYYLPFGPFKELR 288
           ++I    FG   D  N+     L  M + L++  L+  +LL+++ P+L   P      + 
Sbjct: 182 DVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL--TPVFEALNIG 239

Query: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMY--LLHMEEERKNNSNSSFDEEYLFYII 346
              KD+T FLK  I+  +ES  ++  +  +D +  ++  +  ++  S+ +  +  L    
Sbjct: 240 LFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQS 299

Query: 347 GDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDK-AQMPYTEA 405
             +  A  DTT+ +L + +  ++ +PDVQ+K+ EEI+ V+  N+AP   D   QM Y + 
Sbjct: 300 IIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQMEYLDM 358

Query: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYP- 464
            + E  RL  VV   +  +  ++  + G  IPKG  ++  ++++H DP  W +PE F P 
Sbjct: 359 VVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417

Query: 465 NRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPL 523
           +RF       I    +IPFG G R C+G + A   + L  +  +Q+F+F   ++++ PL
Sbjct: 418 SRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPL 476


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.141    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,740,125
Number of Sequences: 37866
Number of extensions: 1119670
Number of successful extensions: 3727
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 70
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 3458
Number of HSP's gapped (non-prelim): 133
length of query: 544
length of database: 18,247,518
effective HSP length: 107
effective length of query: 437
effective length of database: 14,195,856
effective search space: 6203589072
effective search space used: 6203589072
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.