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Search of human proteins with 33620775
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33620775 kinectin 1 isoform a [Homo sapiens]
(1357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118498356 kinectin 1 isoform a [Homo sapiens] 2582 0.0
gi|33620775 kinectin 1 isoform a [Homo sapiens] 2582 0.0
gi|118498362 kinectin 1 isoform b [Homo sapiens] 2459 0.0
gi|118498368 kinectin 1 isoform c [Homo sapiens] 2443 0.0
gi|110611218 ribosome binding protein 1 [Homo sapiens] 265 3e-70
gi|110611220 ribosome binding protein 1 [Homo sapiens] 265 3e-70
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 182 2e-45
gi|71061468 centromere protein E [Homo sapiens] 180 7e-45
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 176 1e-43
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 175 2e-43
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 175 2e-43
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 174 4e-43
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 174 5e-43
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 172 2e-42
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 171 3e-42
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 171 4e-42
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 171 4e-42
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 171 4e-42
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 171 4e-42
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 169 1e-41
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 167 5e-41
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 166 1e-40
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 166 1e-40
gi|156104908 myosin heavy chain 6 [Homo sapiens] 162 2e-39
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 161 5e-39
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 161 5e-39
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 157 5e-38
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 156 1e-37
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 152 2e-36
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 152 2e-36
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2582 bits (6693), Expect = 0.0
Identities = 1357/1357 (100%), Positives = 1357/1357 (100%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 2582 bits (6693), Expect = 0.0
Identities = 1357/1357 (100%), Positives = 1357/1357 (100%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
Query: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA
Sbjct: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
Query: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
Query: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 2459 bits (6374), Expect = 0.0
Identities = 1306/1357 (96%), Positives = 1306/1357 (96%), Gaps = 51/1357 (3%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTV--------- 831
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 832 --------------QLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 877
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 878 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 937
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 938 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 997
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF
Sbjct: 998 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1057
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1058 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1117
Query: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1118 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1177
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1178 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1209
Query: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1210 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1269
Query: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1270 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1306
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 2443 bits (6332), Expect = 0.0
Identities = 1300/1357 (95%), Positives = 1300/1357 (95%), Gaps = 57/1357 (4%)
Query: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK
Sbjct: 1 MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKK 60
Query: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK
Sbjct: 61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKK 120
Query: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
Sbjct: 121 QKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA
Sbjct: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNA 240
Query: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE
Sbjct: 241 DSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE 300
Query: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
Sbjct: 301 ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ 360
Query: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA
Sbjct: 361 EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIA 420
Query: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE
Sbjct: 421 HLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAE 480
Query: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
Sbjct: 481 QAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL 540
Query: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV
Sbjct: 541 VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV 600
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE
Sbjct: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
Sbjct: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ
Sbjct: 721 VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQ 780
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA
Sbjct: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
Sbjct: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT
Sbjct: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD
Sbjct: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
AVEHQRKKNN ERQQQVEAVELEAKEVLKKLF
Sbjct: 1021 AVEHQRKKNN-----------------------------ERQQQVEAVELEAKEVLKKLF 1051
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK
Sbjct: 1052 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1111
Query: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1200
SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE
Sbjct: 1112 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE 1171
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
NLRREREHLEMELEKAEMERSTYVTEVRE LKA
Sbjct: 1172 NLRREREHLEMELEKAEMERSTYVTEVRE----------------------------LKA 1203
Query: 1261 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1320
QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE
Sbjct: 1204 QLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE 1263
Query: 1321 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE
Sbjct: 1264 KETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1300
>gi|110611218 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 265 bits (676), Expect = 3e-70
Identities = 225/804 (27%), Positives = 380/804 (47%), Gaps = 126/804 (15%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
+KQN ++ A L +EL KV E + K + V+ +Q+ KA
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKE------------------LVEKSEAVRQDEQQRKA 421
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
L+ A+ + +V +LQ + EE + L+E ++L +T
Sbjct: 422 LE----------AKAAAFEKQVLQLQASHRESEEALQKR---LDEVSRELCHT------- 461
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Q + SL+A ++ + + A S+ + E ++ K EL L L+E ++ S T
Sbjct: 462 QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLT 521
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
+ ++ + E L Q + QA + L E E ++SGL E L++
Sbjct: 522 ERIRSI--EALLEAGQARDAQDVQASQAEADQQQTRL----KELESQVSGLEKEAIELRE 575
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLK 1077
AVE Q+ KNNDLREKNW+AMEALA+ E+ ++K++ + +E ++Q+ +E + E L
Sbjct: 576 AVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALL 635
Query: 1078 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLEC 1136
L P++SV + +Y EWL ++K + +E L KL+EA+E + LQ EC
Sbjct: 636 ALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAEC 695
Query: 1137 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
++Y+S+LAETEG+L+ LQ+SVE+EE W+ KV + + +++ + + E+ +E+L+ E
Sbjct: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGEL 755
Query: 1197 KDIENLRREREHLEMELEK----AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
+ + +R HLE ELEK A E Y EV L+ LL E Q +LD + SEA +Q+
Sbjct: 756 ESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQS 815
Query: 1253 EELNLLKAQLNE------------------------------------TLTKLRTEQNER 1276
+EL L++ QL+E T L EQ +R
Sbjct: 816 DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQR 875
Query: 1277 QKVAGDLHKAQQSLELIQSKIVK--AAGDTTVIENSDVSPETESSEKETMSVS-LNQTVT 1333
QK+ + +AQ S +Q ++ K AG E + S E EKE S L + T
Sbjct: 876 QKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAAT 935
Query: 1334 QLQQLLQAVNQQLTKEKEHYQVLE 1357
+LQ+LL+ +QL +EK+ + L+
Sbjct: 936 RLQELLKTTQEQLAREKDTVKKLQ 959
Score = 238 bits (607), Expect = 3e-62
Identities = 261/1095 (23%), Positives = 483/1095 (44%), Gaps = 199/1095 (18%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 649 YTEWLQDLKEKGPTLLKHPP------APAEPSSDLASKLREAEETQST----LQAECDQY 698
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
Query: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
Query: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Q++ K+ +++ +LA ++++ +K+HV++ +S + E + V
Sbjct: 803 QLDAAKSEAQKQSDELAL-------VRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV 855
Query: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
+ + +L+ EA+L++ ++ T ++ Q + ++E+L+ ++S
Sbjct: 856 --QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE---- 909
Query: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
E LK+ +E ++K +DL E L +T++ L +
Sbjct: 910 -----------------TEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-RE 951
Query: 1055 NKTSKERQQQVEAVE 1069
T K+ Q+Q+E E
Sbjct: 952 KDTVKKLQEQLEKAE 966
Score = 100 bits (250), Expect = 7e-21
Identities = 173/853 (20%), Positives = 348/853 (40%), Gaps = 169/853 (19%)
Query: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER--------------RWEEVQS 502
RL+ L+EK G +Q + LK QL+E E+ + E+
Sbjct: 236 RLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNK 295
Query: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT----DTLVSKQQLEQRLMQLMESEQ 558
+ A+ A + ++ + VA+E E+ ++ +++ + + QQL+ ++ L E +
Sbjct: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
Query: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV--LAEELHKV---IAEKD 613
N Q+ + ++N L+ + Q SQ+ ++ +A + L +EL KV + EK
Sbjct: 356 NGPNT------QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
Query: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
+ ++Q E Q A E AAA E + +Q
Sbjct: 410 EAVRQDEQ---------------------------------QRKALEAKAAAFEKQVLQL 436
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
++ EE LQ + E + +L+++ +K Q +
Sbjct: 437 QASHRES-----EEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------------EQ 478
Query: 734 EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSF 792
++ + E KL++ E + + +++ +L R ENS LT+ ++ ++A + Q
Sbjct: 479 QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
Query: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE- 851
A V+ + ++ ++K +E +V+ EK +L++ ++ K + +++ +
Sbjct: 539 AQDVQASQAEADQQQTRLKELES-------QVSGLEKEAIELREAVEQQKVKNNDLREKN 591
Query: 852 -KAQQLSITSKV---QELQNLLKGKEE--------QMNTMKAVL----EEKEKDLANTGK 895
KA + T++ ++L +L + KEE + TM+A+L E N +
Sbjct: 592 WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
Query: 896 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 955
WLQDL+E+ +L H A+ + AS + EE + L+ E + ++L E E
Sbjct: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQA---ECDQYRSILAETEGM 708
Query: 956 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
L L + V++E +++++++ +++ + + EE+++ + EL
Sbjct: 709 LRD---LQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLK----------GEL 755
Query: 1016 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEV 1075
+S EH +L EK+ A A + + E Q Q++A + EA++
Sbjct: 756 ESSDQVREHTSHLEAEL-EKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQ 814
Query: 1076 LKKLF----PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTL 1131
+L + S++ G+ +AG S E E D +
Sbjct: 815 SDELALVRQQLSEMKSHVEDGD------------IAGAPASSP----EAPPAEQDPVQLK 858
Query: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
QLE TE IL+ +++ + K+ + ++ Q+S ++ELE+
Sbjct: 859 TQLEW---------TEAILE------DEQTQRQKLTAE-----FEEAQTSACRLQEELEK 898
Query: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
LR+ + E L+ LEK + S +L T LQ+ L + + R+
Sbjct: 899 LRTAGPLESSETEEASQLKERLEKEKKLTS-------DLGRAATRLQELLKTTQEQLARE 951
Query: 1252 NEELNLLKAQLNE 1264
+ + L+ QL +
Sbjct: 952 KDTVKKLQEQLEK 964
>gi|110611220 ribosome binding protein 1 [Homo sapiens]
Length = 977
Score = 265 bits (676), Expect = 3e-70
Identities = 225/804 (27%), Positives = 380/804 (47%), Gaps = 126/804 (15%)
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
A+ L ++++EK I+ T + D + + +L+ E +KL A E
Sbjct: 234 AQRLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLE-----------EKEKLLATEQED 282
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
AA A K+R L +++ E + + Q A + E+ +Q +
Sbjct: 283 AAVAKS-------------KLRELNKEMAAEKAKAAAGEAKVKKQLVAREQEITAVQARM 329
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL-IQVATKEEELNAIRTENSSLTKEVQ 780
+ V E +Q+ K++T++E LE G Q+A ++E + +R + T +V+
Sbjct: 330 QASYREHVKE-----VQQLQGKIRTLQEQLENGPNTQLARLQQENSILRDALNQATSQVE 384
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKA 840
+KQN ++ A L +EL KV E + K + V+ +Q+ KA
Sbjct: 385 ---SKQNAEL--AKLRQELSKVSKE------------------LVEKSEAVRQDEQQRKA 421
Query: 841 LKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
L+ A+ + +V +LQ + EE + L+E ++L +T
Sbjct: 422 LE----------AKAAAFEKQVLQLQASHRESEEALQKR---LDEVSRELCHT------- 461
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Q + SL+A ++ + + A S+ + E ++ K EL L L+E ++ S T
Sbjct: 462 QSSHASLRADAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLT 521
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
+ ++ + E L Q + QA + L E E ++SGL E L++
Sbjct: 522 ERIRSI--EALLEAGQARDAQDVQASQAEADQQQTRL----KELESQVSGLEKEAIELRE 575
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN---KTSKERQQQVEAVELEAKEVLK 1077
AVE Q+ KNNDLREKNW+AMEALA+ E+ ++K++ + +E ++Q+ +E + E L
Sbjct: 576 AVEQQKVKNNDLREKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALL 635
Query: 1078 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG-SEEVKVLEHKLKEADEMHTLLQLEC 1136
L P++SV + +Y EWL ++K + +E L KL+EA+E + LQ EC
Sbjct: 636 ALLPELSVLAQQNYTEWLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQAEC 695
Query: 1137 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
++Y+S+LAETEG+L+ LQ+SVE+EE W+ KV + + +++ + + E+ +E+L+ E
Sbjct: 696 DQYRSILAETEGMLRDLQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLKGEL 755
Query: 1197 KDIENLRREREHLEMELEK----AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
+ + +R HLE ELEK A E Y EV L+ LL E Q +LD + SEA +Q+
Sbjct: 756 ESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQS 815
Query: 1253 EELNLLKAQLNE------------------------------------TLTKLRTEQNER 1276
+EL L++ QL+E T L EQ +R
Sbjct: 816 DELALVRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPVQLKTQLEWTEAILEDEQTQR 875
Query: 1277 QKVAGDLHKAQQSLELIQSKIVK--AAGDTTVIENSDVSPETESSEKETMSVS-LNQTVT 1333
QK+ + +AQ S +Q ++ K AG E + S E EKE S L + T
Sbjct: 876 QKLTAEFEEAQTSACRLQEELEKLRTAGPLESSETEEASQLKERLEKEKKLTSDLGRAAT 935
Query: 1334 QLQQLLQAVNQQLTKEKEHYQVLE 1357
+LQ+LL+ +QL +EK+ + L+
Sbjct: 936 RLQELLKTTQEQLAREKDTVKKLQ 959
Score = 238 bits (607), Expect = 3e-62
Identities = 261/1095 (23%), Positives = 483/1095 (44%), Gaps = 199/1095 (18%)
Query: 21 IFLFFWLFMKETLYDEVLAKQKREQ-KLIPTKTDKKKAEK------KKNKKKEIQNGNLH 73
IFL MKET Y+E LA Q++E K K +KKK EK K KK+E NG +
Sbjct: 25 IFLVSTFSMKETSYEEALANQRKEMAKTHHQKVEKKKKEKTVEKKGKTKKKEEKPNGKI- 83
Query: 74 ESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKE 132
D + P L + + VAP P+ Q P++
Sbjct: 84 -PDHDPAPNVTVLLREPVRAPAVAVAPTPV------------------QPPIIV------ 118
Query: 133 SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ---DKKVETLMVPSK 189
PV P P E AS K +KK K + + V ++ V +
Sbjct: 119 -------------APVATVPAMPQEKLASSPKDKKKKEKKVAKVEPAVSSVVNSIQVLTS 165
Query: 190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKR 249
+ L ET + G A S P K+
Sbjct: 166 KAAIL----ETAPKEGRNTDVAQS------------------------------PEAPKQ 191
Query: 250 EVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLK 309
E +KSG+KK + +K + ++ +M+F+E EA ++++L
Sbjct: 192 EA---------PAKKKSGSKKKGPPDADGPLYLPYKTLVSTVGSMVFNEGEAQRLIEILS 242
Query: 310 EKSGVIQDALKKSS-KGELTTLI-HQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKE 367
EK+G+IQD K++ KG+ ++ QL+EK+KLLA +EDAA K + ++L +EM EK
Sbjct: 243 EKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNKEMAAEKA 302
Query: 368 RSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----TQQMQMKFQQVREQME----AEI 419
++ ++K ++ E+E Q ++ SY+E QQ+Q K + ++EQ+E ++
Sbjct: 303 KAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLENGPNTQL 362
Query: 420 AHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNA 479
A L+QEN ILRDA++ T+Q+ESKQ+AEL KLRQ+ +++ EL EK+ ++Q+E Q+K
Sbjct: 363 ARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKSEAVRQDEQQRKAL 422
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE-NEVQSLHSKLTD 538
E A + Q+ + + E + ++KR E V++E QS H+ L
Sbjct: 423 EAKAAAFEKQVLQLQASHRESEEALQKRLDE------------VSRELCHTQSSHASLRA 470
Query: 539 TLVSKQQLEQRLMQL---MESEQKRVNKE----ESLQMQVQDILEQNEALKAQIQQFHSQ 591
Q+ +Q++ +L ++S + V + L Q+Q+ +N L +I+ +
Sbjct: 471 DAEKAQEQQQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEAL 530
Query: 592 IAAQTSASVLAEELHKVIAEKDKQ---IKQTEDSLAS-ERDRLTSKEEELKDIQNMNFLL 647
+ A + A+++ AE D+Q +K+ E ++ E++ + +E + N L
Sbjct: 531 LEAGQARD--AQDVQASQAEADQQQTRLKELESQVSGLEKEAIELREAVEQQKVKNNDLR 588
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+ + ++ALA + A +L + Q+ + ++ L+E Q + + E +L QN
Sbjct: 589 EKNWKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQN 648
Query: 708 --KALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ L+ +K TL+ P + + KL+ EE T + + ++
Sbjct: 649 YTEWLQDLKEKGPTLLKHPP------APAEPSSDLASKLREAEETQST----LQAECDQY 698
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVA 825
+I E + +++Q VEE ++V K G + EE L+ + V
Sbjct: 699 RSILAETEGMLRDLQ-------------KSVEEEEQVWRAKVG---AAEEELQKSRVTVK 742
Query: 826 NKEKTVQDLKQEIKA---LKEEIGNVQLEKAQQLSITS--------KVQELQNLLKGKEE 874
+ E+ V+ LK E+++ ++E +++ E + ++ S +V L+ LL +
Sbjct: 743 HLEEIVEKLKGELESSDQVREHTSHLEAELEKHMAAASAECQNYAKEVAGLRQLLLESQS 802
Query: 875 QMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIV 934
Q++ K+ +++ +LA ++++ +K+HV++ +S + E + V
Sbjct: 803 QLDAAKSEAQKQSDELAL-------VRQQLSEMKSHVEDGDIAGAPASSPEAPPAEQDPV 855
Query: 935 LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH 994
+ + +L+ EA+L++ ++ T ++ Q + ++E+L+ ++S
Sbjct: 856 --QLKTQLEWTEAILEDEQTQRQKLTAEFEEAQTSACRLQEELEKLRTAGPLESSE---- 909
Query: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV 1054
E LK+ +E ++K +DL E L +T++ L +
Sbjct: 910 -----------------TEEASQLKERLEKEKKLTSDLGRAATRLQELLKTTQEQLA-RE 951
Query: 1055 NKTSKERQQQVEAVE 1069
T K+ Q+Q+E E
Sbjct: 952 KDTVKKLQEQLEKAE 966
Score = 100 bits (250), Expect = 7e-21
Identities = 173/853 (20%), Positives = 348/853 (40%), Gaps = 169/853 (19%)
Query: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER--------------RWEEVQS 502
RL+ L+EK G +Q + LK QL+E E+ + E+
Sbjct: 236 RLIEILSEKAGIIQDTWHKATQKGDPVAILKRQLEEKEKLLATEQEDAAVAKSKLRELNK 295
Query: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLT----DTLVSKQQLEQRLMQLMESEQ 558
+ A+ A + ++ + VA+E E+ ++ +++ + + QQL+ ++ L E +
Sbjct: 296 EMAAEKAKAAAGEAKVKKQLVAREQEITAVQARMQASYREHVKEVQQLQGKIRTLQEQLE 355
Query: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV--LAEELHKV---IAEKD 613
N Q+ + ++N L+ + Q SQ+ ++ +A + L +EL KV + EK
Sbjct: 356 NGPNT------QLARLQQENSILRDALNQATSQVESKQNAELAKLRQELSKVSKELVEKS 409
Query: 614 KQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQ 673
+ ++Q E Q A E AAA E + +Q
Sbjct: 410 EAVRQDEQ---------------------------------QRKALEAKAAAFEKQVLQL 436
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQM 733
++ EE LQ + E + +L+++ +K Q +
Sbjct: 437 QASHRES-----EEALQKRLDEVSRELCHTQSSHASLRADAEKAQ-------------EQ 478
Query: 734 EKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK-QNDQVSF 792
++ + E KL++ E + + +++ +L R ENS LT+ ++ ++A + Q
Sbjct: 479 QQQMAELHSKLQSSEAEVRSKCEELSGLHGQLQEARAENSQLTERIRSIEALLEAGQARD 538
Query: 793 ASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE- 851
A V+ + ++ ++K +E +V+ EK +L++ ++ K + +++ +
Sbjct: 539 AQDVQASQAEADQQQTRLKELES-------QVSGLEKEAIELREAVEQQKVKNNDLREKN 591
Query: 852 -KAQQLSITSKV---QELQNLLKGKEE--------QMNTMKAVL----EEKEKDLANTGK 895
KA + T++ ++L +L + KEE + TM+A+L E N +
Sbjct: 592 WKAMEALATAEQACKEKLHSLTQAKEESEKQLCLIEAQTMEALLALLPELSVLAQQNYTE 651
Query: 896 WLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD 955
WLQDL+E+ +L H A+ + AS + EE + L+ E + ++L E E
Sbjct: 652 WLQDLKEKGPTLLKHPPAPAEPSSDLASKLREAEETQSTLQA---ECDQYRSILAETEGM 708
Query: 956 LSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
L L + V++E +++++++ +++ + + EE+++ + EL
Sbjct: 709 LRD---LQKSVEEEEQVWRAKVGAAEEELQKSRVTVKHLEEIVEKLK----------GEL 755
Query: 1016 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEV 1075
+S EH +L EK+ A A + + E Q Q++A + EA++
Sbjct: 756 ESSDQVREHTSHLEAEL-EKHMAAASAECQNYAKEVAGLRQLLLESQSQLDAAKSEAQKQ 814
Query: 1076 LKKLF----PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTL 1131
+L + S++ G+ +AG S E E D +
Sbjct: 815 SDELALVRQQLSEMKSHVEDGD------------IAGAPASSP----EAPPAEQDPVQLK 858
Query: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
QLE TE IL+ +++ + K+ + ++ Q+S ++ELE+
Sbjct: 859 TQLEW---------TEAILE------DEQTQRQKLTAE-----FEEAQTSACRLQEELEK 898
Query: 1192 LRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
LR+ + E L+ LEK + S +L T LQ+ L + + R+
Sbjct: 899 LRTAGPLESSETEEASQLKERLEKEKKLTS-------DLGRAATRLQELLKTTQEQLARE 951
Query: 1252 NEELNLLKAQLNE 1264
+ + L+ QL +
Sbjct: 952 KDTVKKLQEQLEK 964
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 182 bits (462), Expect = 2e-45
Identities = 246/1112 (22%), Positives = 496/1112 (44%), Gaps = 143/1112 (12%)
Query: 261 EGIQKSGTKKLKTE---TDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
E + K K+L E T+ E + + L L+ + +E E + L+
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR-------- 903
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A + K EL + H L+ A V+E+ ++RC Q + EK++ I ++
Sbjct: 904 ARLTAKKQELEEICHDLE------ARVEEE----EERC----QHLQAEKKKMQQNIQELE 949
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTT 437
++ LE+E + Q K+ + T+ K ++ + +E + L +E +L D ++ T
Sbjct: 950 EQ---LEEEESARQ-KLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 438 NQL--ESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
L E ++S L KL+ + ++ +L E+ L++EE Q++ E+ +L+ +
Sbjct: 1006 TNLTEEEEKSKSLAKLKNKHEAMITDLEER---LRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
+ E+Q+ I + + +++LQ+ E E + L + Q+ + L + +E
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLE 1121
Query: 556 SEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DK 614
SE+ NK E Q +D+ E+ EALK +++ AAQ E+ ++ + ++
Sbjct: 1122 SERASRNKAEK---QKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178
Query: 615 QIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQQ 673
+ K E + R + + EEL + +KA ++K Q L NE+ A+E++ + Q
Sbjct: 1179 EAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQ 1238
Query: 674 SVYVKDDKIRLLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDV 729
+ K + +E QLQ E+ K E + L D+ L+ E+ + L+S+ +K
Sbjct: 1239 GKGDSEHKRKKVEAQLQ-ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSS 1297
Query: 730 ------------VEQMEKCIQEKDE-------KLKTVEELLETGLIQVATKEEELNAIRT 770
++ ++ +QE++ KLK VE+ + Q+ +EE + +
Sbjct: 1298 KLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEK 1357
Query: 771 ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKT 830
+ ++L +V D+K K D V EE+K+ + +KD ++ + + E ++ EKT
Sbjct: 1358 QIATLHAQVADMKKKMEDSVGCLETAEEVKRKL-QKD--LEGLSQRHEEKVAAYDKLEKT 1414
Query: 831 VQDLKQEIKALKEEIGNVQ-----LEK---------AQQLSITSKVQELQNLLKG----K 872
L+QE+ L ++ + + LEK A++ +I++K E ++ + K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 873 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ--HNLKEASSA--SQF 928
E + ++ LEE + A + + + E E L + +V + H L+++ A Q
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQV 1534
Query: 929 EELEIVLKEKENELKRLEAMLKERESDLSS-KTQLLQDVQDENKLFKSQIEQL-KQQNYQ 986
EE++ L+E E+EL+ E E +L + K Q +D+Q ++ + + +QL +Q
Sbjct: 1535 EEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREM 1594
Query: 987 QASSFPPHEELLKVISEREK---EISGLWNELDSLK----DAVEHQRKKNNDLREKNWEA 1039
+A ++ ++ R+K ++ L +DS +A++ RK +++ E
Sbjct: 1595 EAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL 1654
Query: 1040 MEALASTEKMLQDKVNKTSKERQQQVEAVELE--------AKEVLKKLFPKVSVPSNLSY 1091
+ AS E++L K + + E ++L+ AK ++ +++ S
Sbjct: 1655 DDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSS 1714
Query: 1092 GEWLHGFEKKAKECMAGTSGSEEVK-------VLEHKLKEA----DEMHTLLQLECEKYK 1140
G+ E+K + EE++ ++ +LK+A D+++T L LE +
Sbjct: 1715 GKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE----R 1770
Query: 1141 SVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK-QMQSSFTSSEQELERLRSENKDI 1199
S + E Q+L+R + + KVK+ E T+K + ++S T+ E ++ +L
Sbjct: 1771 SHAQKNENARQQLER----QNKELKVKLQEMEGTVKSKYKASITALEAKIAQL------- 1819
Query: 1200 ENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLK 1259
E +L+ ER +VR + L ++ ++DD A + ++ +
Sbjct: 1820 ----------EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS 1869
Query: 1260 AQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1291
+L + +L + E Q+ K Q+ LE
Sbjct: 1870 TRLKQLKRQLEEAEEEAQRANASRRKLQRELE 1901
Score = 166 bits (419), Expect = 2e-40
Identities = 203/956 (21%), Positives = 437/956 (45%), Gaps = 87/956 (9%)
Query: 433 VSNTTNQLESKQSAELNKLRQDYARLVNELTEKT---GKLQQEEVQKKNAEQAATQLKVQ 489
VS ++ +K+ EL K+R+ N LTE +L E++Q + QA T+L +
Sbjct: 840 VSRQEEEMMAKEE-ELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAE 898
Query: 490 LQEAERRW-------EEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVS 542
+E R EE+ + R E E Q LQ++ + +Q L +L + +
Sbjct: 899 AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 543 KQQLEQRLMQLMESEQKRVNKEES-LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
+Q+L+ + E++ K++ +E+ L+ Q + ++ + L+ +I +F + + + S
Sbjct: 959 RQKLQLEKVTT-EAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKS-- 1015
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
+ L K+ + + I E+ L E + E+ + ++ + L ++ +LQA
Sbjct: 1016 -KSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQA----- 1069
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT-L 720
++ +++ + K+++++ +++ E + K K + + L+S++ +LQ L
Sbjct: 1070 -----QIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRE----LESQISELQEDL 1120
Query: 721 VSEQPNKDVVEQMEKCIQEKDEKLKT-VEELLETGLIQV---ATKEEELNAIRT--ENSS 774
SE+ +++ E+ ++ + E+ E LKT +E+ L++ Q + +E+E+N ++ E +
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180
Query: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
T E Q + +Q + L E+L++ K ++ ++ LE E ++AN+ K +
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVK-ANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 835 KQEIKALKEEIGNVQLEKAQ---------QLSITSKVQELQNLLKGKEEQMNTMKAVLEE 885
K + + ++++ QL++ Q + + KV +LQ L ++ + +
Sbjct: 1240 KGDSEHKRKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSK 1298
Query: 886 KEKDLANTGKWLQD----LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENE 941
KD + LQD LQEEN + ++ Q ++ S Q EE E E +
Sbjct: 1299 LTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQ 1358
Query: 942 LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1001
+ L A + + + + L+ ++ + + +E L Q+ HEE +
Sbjct: 1359 IATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQR----------HEEKVAAY 1408
Query: 1002 SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKER 1061
+ EK + L ELD L ++HQR+ +L EK + + L + EK + K +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNL-EKKQKKFDQLLAEEKTISAKYAEERDRA 1467
Query: 1062 QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHK 1121
+ + E +A + + L + + L F + ++ M S ++V H+
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELE--RLNKQFRTEMEDLM---SSKDDVGKSVHE 1522
Query: 1122 LKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSS 1181
L+++ L+ + E+ K+ L E E LQ E+ K +++V+ ++ M++
Sbjct: 1523 LEKSKRA---LEQQVEEMKTQLEELEDELQAT------EDAKLRLEVN-----LQAMKAQ 1568
Query: 1182 FTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKL 1241
F Q + +SE K + +R+ RE +E ELE +RS V ++L+ L +L+ +
Sbjct: 1569 FERDLQGRDE-QSEEKKKQLVRQVRE-MEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 1242 DDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAA 1301
D + ++L L+AQ+ + + +L + R+++ + ++ L+ +++++++
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 1302 GDTTVIENSDVSPETESSE-KETMSVSLNQTVTQLQQ--LLQAVNQQLTKEKEHYQ 1354
+ E + + E E + ++ S + L++ L+A QL +E E Q
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQ 1742
Score = 150 bits (379), Expect = 8e-36
Identities = 198/852 (23%), Positives = 384/852 (45%), Gaps = 108/852 (12%)
Query: 550 LMQLMESEQKRVNKEESL------QMQVQDILEQNEALKAQIQ----QFHSQIAAQTSAS 599
L+Q+ E++ + KEE L Q+ ++ L + E L++Q+ Q Q+ A+T
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELC 896
Query: 600 VLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALAN 659
AEEL + K +++++ L + R+ +EE + +Q ++ +Q+L+
Sbjct: 897 AEAEELRARLTAKKQELEEICHDLEA---RVEEEEERCQHLQAEKKKMQQNIQELEEQLE 953
Query: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
E+ +A +K+Q + K++ LEE E IL DQN L E + L+
Sbjct: 954 EEESAR---QKLQLEKVTTEAKLKKLEE-----------EQIILEDQNCKLAKEKKLLED 999
Query: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE----ELNAIRT----E 771
++E ++ E+ EK + KLK E + T L + +EE EL R +
Sbjct: 1000 RIAEFTT-NLTEEEEK--SKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD 1056
Query: 772 NSSLTKEVQDLKAKQND-QVSFASLVEELK-----------------KVIHEKDGKIKSV 813
++ L+ ++ +L+A+ + ++ A EEL+ K I E + +I +
Sbjct: 1057 STDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISEL 1116
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK- 872
+E LE+E EK +DL +E++ALK E+ + A Q + SK ++ N+LK
Sbjct: 1117 QEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTL 1176
Query: 873 EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELE 932
EE+ T +A ++E + + + L + E+ + +KA++++ Q E + E++
Sbjct: 1177 EEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA--NEVK 1234
Query: 933 IVLKEK---ENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQAS 989
++L+ K E++ K++EA L+E + + ++ ++ D K+ K Q+E L +
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELAD--KVTKLQVE-LDNVTGLLSQ 1291
Query: 990 SFPPHEELLKVISEREKEISGLWNELD-------SLKDAVEHQRKKNNDLREKNWEAMEA 1042
S +L K S E ++ L SL ++ + N RE+ E EA
Sbjct: 1292 SDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEA 1351
Query: 1043 LASTEKM---LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE 1099
+ EK L +V K+ + V +E A+EV +KL + L G
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLE-TAEEVKRKL------------QKDLEGLS 1398
Query: 1100 KKAKECMAGTSGSEEVKV-----LEHKLKEADEMHTL---LQLECEKYKSVLAETEGILQ 1151
++ +E +A E+ K L+ L + D L+ + +K+ +LAE + I
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458
Query: 1152 KLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSE-NKDIENLRREREHLE 1210
K ++ E + + K ++ + ++ + + ELERL + ++E+L ++ +
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAM-EQKAELERLNKQFRTEMEDLMSSKDDVG 1517
Query: 1211 MELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR 1270
+ + E + +V E+K L EL+ +L + +R L +KAQ L + R
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL-QGR 1576
Query: 1271 TEQNERQK--VAGDLHKAQQSL--ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSV 1326
EQ+E +K + + + + L E Q + AA ++ D+ +S+ K
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANK----- 1631
Query: 1327 SLNQTVTQLQQL 1338
+ ++ + QL++L
Sbjct: 1632 NRDEAIKQLRKL 1643
Score = 131 bits (329), Expect = 5e-30
Identities = 231/1081 (21%), Positives = 450/1081 (41%), Gaps = 155/1081 (14%)
Query: 105 VETSSSVRERKKKEK-----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEA 158
+E S R++ + EK K K + EEQ+I E K+ KK+ + + T +E
Sbjct: 952 LEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEE 1011
Query: 159 AASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGS-----GKKKASS 213
K + K+K+ + D + +RQE ++ + +S + +A
Sbjct: 1012 EEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071
Query: 214 KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273
+ K + +E L A + + A + + K ++ + E ++ + K
Sbjct: 1072 AELKMQLAKKEEELQAALARVE-EEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
E K + + L +LKT + ++ L+ K + LKK+ + E T Q
Sbjct: 1131 EKQKRD----LGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQ 1186
Query: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK 393
+QE + + Q +E+ + E++ V ++ TLE E N+
Sbjct: 1187 IQE--------------MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANE 1232
Query: 394 IHVSYQ--------------ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQ 439
+ V Q + Q++Q+KF + E++ E+A + + D V+ +Q
Sbjct: 1233 VKVLLQGKGDSEHKRKKVEAQLQELQVKFNE-GERVRTELADKVTKLQVELDNVTGLLSQ 1291
Query: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEE 499
+SK S KL +D++ L ++L + LQ+E QK + +T+LK + E+
Sbjct: 1292 SDSKSS----KLTKDFSALESQLQDTQELLQEENRQKLS---LSTKLK--------QVED 1336
Query: 500 VQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL-------VSKQQLEQRLMQ 552
++ R++ E E A+ +L+ + +V + K+ D++ K++L++ L
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 553 LMESEQKRV-------NKEESLQMQVQDIL------EQNEALKAQIQQFHSQIAAQ--TS 597
L + +++V + LQ ++ D+L Q+ + Q+ Q+ A+ T
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 598 ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQAL 657
++ AEE + AE ++ E S L E+ +++ +N + E++ L +
Sbjct: 1457 SAKYAEERDRAEAE----AREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSS 1512
Query: 658 ANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL 717
++ + HELEK + R LE+Q++ E+ ++EE L D+ +A +E KL
Sbjct: 1513 KDDVGKSVHELEKSK----------RALEQQVE-EMKTQLEE---LEDELQA--TEDAKL 1556
Query: 718 QTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENS---- 773
+ V+ Q K Q E+ +Q +DE+ EE + + QV E EL R + S
Sbjct: 1557 RLEVNLQAMK---AQFERDLQGRDEQ---SEEKKKQLVRQVREMEAELEDERKQRSMAVA 1610
Query: 774 ---SLTKEVQDLKA------KQNDQV--SFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
L +++DL+A K D+ L ++K + E D S EE+ L
Sbjct: 1611 ARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEI----LA 1666
Query: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAV 882
+ EK ++ ++ E+ L+EE+ + K Q QE L
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERAKRQ------AQQERDELADEIANSSGKGALA 1720
Query: 883 LEEKEKDLANTGKWLQDLQEE-------NESLKAHVQEVAQHNLKEASSASQFEELEIVL 935
LEEK + A + ++L+EE N+ LK ++ Q N S ++ E
Sbjct: 1721 LEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENAR 1780
Query: 936 KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHE 995
++ E + K L+ L+E E + SK + +++I QL++Q + +
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSK------YKASITALEAKIAQLEEQLDNETKE---RQ 1831
Query: 996 ELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVN 1055
K + EK++ + ++D + E + + + + + L E+ Q + N
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ-RAN 1890
Query: 1056 KTSKERQQQVEAVELEAKEVLKKLFPKV-SVPSNLSYGEWLHGFEKKAKECMAGTSGSEE 1114
+ ++ Q+++E +A E + +V S+ + L G+ ++ AG EE
Sbjct: 1891 ASRRKLQRELE----DATETADAMNREVSSLKNKLRRGDLPFVVPRRMARKGAGDGSDEE 1946
Query: 1115 V 1115
V
Sbjct: 1947 V 1947
Score = 99.0 bits (245), Expect = 3e-20
Identities = 137/569 (24%), Positives = 252/569 (44%), Gaps = 82/569 (14%)
Query: 814 EELL--EAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS----ITSKVQELQN 867
EE++ E EL+KV K+ ++ E++ L+ ++ +L+ +QL + ++ +EL+
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 868 LLKGKEEQM----NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
L K++++ + ++A +EE+E+ Q LQ E + ++ ++QE+ + L+E
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERC-------QHLQAEKKKMQQNIQEL-EEQLEEEE 956
Query: 924 SASQFEELEIVLKE-KENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ 982
SA Q +LE V E K +L+ + +L+++ L+ + +LL+D E F + + + ++
Sbjct: 957 SARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAE---FTTNLTEEEE 1013
Query: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042
++ A HE ++ + ER + EL+ + +E + DL ++ E
Sbjct: 1014 KSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGD---STDLSDQIAELQAQ 1070
Query: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKE---VLKKLFPKVSVPSNLSYGEWLHGFE 1099
+A + L K +E Q + VE EA + LKK+ S S L
Sbjct: 1071 IAELKMQLAKK----EEELQAALARVEEEAAQKNMALKKIRELESQISELQ--------- 1117
Query: 1100 KKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET---EGILQKLQRS 1156
E+++ +A++ L E E K+ L +T Q+L+
Sbjct: 1118 -------------EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 1157 VEQEENKWKVKVDESHKTIK-QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1215
EQE N K ++E KT + Q+Q Q +E L + +E +R + +LE +
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ---LEQTKRVKANLEKAKQT 1221
Query: 1216 AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNE 1275
E ER EV+ L LQ K D SE R+ E AQL E K +
Sbjct: 1222 LENERGELANEVKVL------LQGKGD---SEHKRKKVE-----AQLQELQVKFNEGERV 1267
Query: 1276 RQKVAGDLHKAQQSLELI-------QSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
R ++A + K Q L+ + SK K D + +E+ + E+ +SL
Sbjct: 1268 RTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSL 1327
Query: 1329 NQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ + Q++ + +QL +E+E LE
Sbjct: 1328 STKLKQVEDEKNSFREQLEEEEEAKHNLE 1356
Score = 71.6 bits (174), Expect = 5e-12
Identities = 125/700 (17%), Positives = 279/700 (39%), Gaps = 88/700 (12%)
Query: 57 AEKKKNKKKEIQN--GNLHESDSES--VPRDFKLSDA--------LAVEDDQVAPVPLN- 103
A+K + E+ N G L +SDS+S + +DF ++ L E+ Q +
Sbjct: 1272 ADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL 1331
Query: 104 --VVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAAS 161
V + +S RE+ ++E++ K LE+Q+ KK+E + +
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 162 KKKPG---QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKT 218
K G + + K + D+ +K +T + + + L + + +++S +K K++K
Sbjct: 1392 KDLEGLSQRHEEKVAAYDKLEKTKTRL--QQELDDLLVDLDHQRQSACNLEK---KQKKF 1446
Query: 219 ENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKL------- 271
+ + +E I A Y D A++ + + + L + + QK+ ++L
Sbjct: 1447 DQLLAEEKTISAK-YAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTE 1505
Query: 272 ------------KTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL 319
K+ + E ++ + + +KT + ++ L + K + V A+
Sbjct: 1506 MEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 320 KKSSKGELTTLIHQLQEKDK-LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
K + +L Q +EK K L+ V+E A +D KQ + + K + + + ++
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARK-KLEMDLKDLEA 1624
Query: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
I + K + ++ + + + R E +A K+ L+ +
Sbjct: 1625 HIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQ 1684
Query: 439 QLESKQSAELNK--LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496
E +AE K +Q+ L +E+ +GK +K+ E QL+ +L+E +
Sbjct: 1685 LQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN 1744
Query: 497 WEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
E + ++K + + DL
Sbjct: 1745 TELINDRLKKANLQIDQINTDL------------------------------------NL 1768
Query: 557 EQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
E+ K E+ + Q++ QN+ LK ++Q+ + ++ AS+ A L IA+ ++Q+
Sbjct: 1769 ERSHAQKNENARQQLE---RQNKELKVKLQEMEGTVKSKYKASITA--LEAKIAQLEEQL 1823
Query: 617 KQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVY 676
+ ++ E++LKD+ + ++ + A++ + +L++ +
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883
Query: 677 VKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+ + +LQ E+ + E +N + +LK+++++
Sbjct: 1884 EEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 180 bits (457), Expect = 7e-45
Identities = 308/1448 (21%), Positives = 618/1448 (42%), Gaps = 249/1448 (17%)
Query: 30 KETLYDEVLAKQKREQKLIP----TKTDKKKAEKK-KNKKKEIQN-GNLHES-------- 75
K+ L+ EV+ K+ R Q L+ TK D + K+ +E QN LH
Sbjct: 777 KDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMV 836
Query: 76 --DSESVPRDF--------KLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVL 125
++E + ++ K +L +++ + E + V+ER + ++ K L
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 126 EEQ------VIKESD--ASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQ 177
E + V +E K+ E +T++ + S + + + D
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTV 956
Query: 178 DKKVETLMVPSKRQEALPLHQET----------------KQESGSGKKKASSKKQKTENV 221
+ ++T E+L HQET E +G+ K +QK +
Sbjct: 957 NMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETK-DEFQQKMVGI 1015
Query: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTETD-KE 278
+ L T D D+ + +R++ L+ K + + ++ +K + +TD KE
Sbjct: 1016 DKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKE 1075
Query: 279 NAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD----ALKKSSKGELTTLIHQL 334
N E+ ++ ++E + D LK++ ++ A+KK +GEL+ +L
Sbjct: 1076 NIEMTIEN-----------QEELRLLGDELKKQQEIVAQEKNHAIKK--EGELSRTCDRL 1122
Query: 335 QEKDKLLAAVKEDAAATKDRCKQL--TQEMMTEKERSNVVITRMKDRIGT-------LEK 385
E ++ L KE + +++ +QL QE M+E ++ I +K+ + +E
Sbjct: 1123 AEVEEKL---KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179
Query: 386 EHNVFQNKIHVSYQETQQMQMK---FQQVREQMEAEIAHLKQENGILRDAVSNTTNQLES 442
E K++ +Y+E + + + +++++ E E HL+ G +R+ + E
Sbjct: 1180 ERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLR---GYIREIEATGLQTKEE 1236
Query: 443 KQSAELN-----KLRQDYARLVNELT---------EKTGKLQQEEVQKKNAEQAATQLKV 488
+ A ++ + + R V+E T EK+ QEE+ + EQ
Sbjct: 1237 LKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVK 1296
Query: 489 QLQEAERRWEEVQSYIRKRT-------AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
++ E + E++ + T A E + L KF + E++SL + +
Sbjct: 1297 EVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKT 1356
Query: 542 SKQQLEQRLMQLMES--------EQKRVNKEESLQMQVQDILEQNEALK--AQIQQFHSQ 591
K+ LE + QL E ++ + +E+SL M+ +D NE K ++++QF +
Sbjct: 1357 IKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKD----NETTKIVSEMEQFKPK 1412
Query: 592 IAA-------QTSASVLAEELH---KVIAEKDKQIKQTEDSLASERDRLTSK-------- 633
+A S +E H K +A++ +++ ++ L SE D+L
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 634 ---EEELK-----------DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKD 679
EEELK I + L + ++ + + A +L+ Q +Y K+
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 680 DKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK--DVVEQMEKCI 737
++ + + E+ K+ E K + KA S +Q +++ + E N+ + E+++ I
Sbjct: 1533 EQFNIKQIS---EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMI 1589
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQ-NDQVSFASLV 796
+EK+E +K V+E L+ Q+ +E+ A E+ KE Q LK N+ +
Sbjct: 1590 KEKEE-MKRVQEALQIERDQLKENTKEIVAKMKESQE--KEYQFLKMTAVNETQEKMCEI 1646
Query: 797 EELKKVIHEKDGKIKSVE-------ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ 849
E LK+ + ++++E ++L L ++ + K DL+ + LK E Q
Sbjct: 1647 EHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVE--RDQ 1704
Query: 850 LEKAQQLSITSKVQELQNL------LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEE 903
L++ + +IT +++ + L LK +E ++ ++ ++ EK +++N K DL+
Sbjct: 1705 LKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQK---DLEHS 1761
Query: 904 NESLKAHVQEVAQHNLKEASSASQFEELEIV---LKEKENELKRLEAMLKERESDLSSKT 960
N++LKA ++ EEL I LKE++ + +L ++ E+ LS+
Sbjct: 1762 NDALKAQDLKIQ-------------EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSN-- 1806
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
+ +D+++ N + +I++LK +Q + L K ++E +K++S E++ LK
Sbjct: 1807 -MQKDLENSNAKLQEKIQELKANEHQLIT-------LKKDVNETQKKVS----EMEQLKK 1854
Query: 1021 AVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLF 1080
++ Q + L +N + L + ++ + + R+ + E ++LE ++ + L
Sbjct: 1855 QIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE-ETLKLERDQLKESL- 1912
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYK 1140
+ + +L + L +KE E V L K+ E + +Q + +K K
Sbjct: 1913 -QETKARDLEIQQELKTARMLSKE------HKETVDKLREKISEKTIQISDIQKDLDKSK 1965
Query: 1141 SVLAETEGILQKLQRS---VEQEENKWKVKVDESHKTIKQ-------MQSSFTSSEQELE 1190
L + LQK + V+++ N K++E + KQ MQS + Q +
Sbjct: 1966 DELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTK 2025
Query: 1191 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL-------------KDLLTEL 1237
+L ++I + +ER+ L E +MER ++ +RE+ K LL++
Sbjct: 2026 KLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDG 2085
Query: 1238 QKKLDDSYSEAVRQNEELNLLKAQLN---ETLTKLRTE---QNERQKVAGDLHKAQQSLE 1291
Q+ L +S E + +EL ++++ E L +L + + E QK KA SL
Sbjct: 2086 QQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLP 2145
Query: 1292 LIQSKIVK 1299
+Q+K ++
Sbjct: 2146 YLQTKHIE 2153
Score = 180 bits (457), Expect = 7e-45
Identities = 256/1237 (20%), Positives = 524/1237 (42%), Gaps = 198/1237 (16%)
Query: 269 KKLKTETDKENAEV--------KFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK 320
K + E ++ N E+ KF L +LKT + + + L +EK+ +Q+ L
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQEL------QEKTREVQERLN 887
Query: 321 KSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRI 380
E+ L QL+ +D L V+ + ++ +Q +E+ T +T+ KD +
Sbjct: 888 -----EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKT--------LTQEKDDL 934
Query: 381 GTLEKEHNVFQNKIHVSYQETQQMQMKFQ-QVREQMEA-----------------EIA-- 420
L++ + ++++ +T M + Q Q+R +E+ E++
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRN 994
Query: 421 -HLKQENGILRDAVSNTTNQLESKQSAEL------------NKLRQDYARLVNELTEKTG 467
H+++ G +D ++ KQ E N++ + ++ + + EK
Sbjct: 995 LHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNE 1054
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
Q E EQ T LK ++ EE++ + + E Q+ ++ + KE
Sbjct: 1055 LQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQE-KNHAIKKEG 1113
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE----QNEALKA 583
E+ +L + +++L+++ QL E +Q+ +N +E + + I E +NE
Sbjct: 1114 ELSRTCDRLAEV---EEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNK 1170
Query: 584 QIQQFHSQIAAQTSASVLAEELHKV--IAEKDKQIKQTEDSLASERDRLTS--KEEELKD 639
++ H + A L E +V I ++ K +K+ + S +ERD L +E E
Sbjct: 1171 ELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 640 IQNMNFLLKAEVQ---------KLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ 690
+Q L A + +L+ +E+ A + +++S ++I +L E+ +
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQE 1290
Query: 691 --------HEISNKMEEFKILNDQNKALKSEVQ---KLQTLVSEQPNKDVVEQMEKCIQE 739
E M E ++L +Q+ S +++ L + ++ E+++ +E
Sbjct: 1291 LLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKE 1350
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEEL 799
+D LKT++E LE Q+ E A E+ S ++ ++K K N+ S +E+
Sbjct: 1351 RDN-LKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQF 1409
Query: 800 K-------KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIG-NVQLE 851
K ++ E G K ++E + E+ VA ++ +Q L++ +++ +++ N++
Sbjct: 1410 KPKDSALLRIEIEMLGLSKRLQESHD-EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI 1468
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
A+ L +++ LK +EE +N ++ L EKE +++ K L+ + N+ L+ +
Sbjct: 1469 VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI---NDKLQNKI 1525
Query: 912 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSS-------KTQLLQ 964
QE+ + +E + Q E++ EK NELK+ + K ++S L S T LQ
Sbjct: 1526 QEI--YEKEEQFNIKQISEVQ----EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ 1579
Query: 965 DVQDENKLFKSQIEQLKQ-----QNYQQASSFPPHEELLKVISEREKEISGL-------- 1011
+ Q+E ++ + E++K+ Q + E + K+ +EKE L
Sbjct: 1580 ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639
Query: 1012 ---WNELDSLKDAVEHQRKKNNDLREKN-------WEAMEALASTEKMLQD--KVNKTSK 1059
E++ LK+ E Q+ ++ +N E +E + S K D V +T K
Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK 1699
Query: 1060 ------------------ERQQQVEAVELEAKE---VLKKLFPKVSVPSNLSYGEWLHGF 1098
E+Q++++ V + KE + KL VS +N +
Sbjct: 1700 VERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNE-----ISNM 1754
Query: 1099 EKKAKECMAGTSGS-----EEVKVLEHKLKEA----DEMHTLLQLECEKYKSVLAETEGI 1149
+K + EE+++ LKE D++ ++ + +K ++ + E
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 1150 LQKLQRSVEQ-------------EENKWKVKVDESHKTIKQMQS-SFTSSEQELERLRSE 1195
KLQ +++ + N+ + KV E + KQ++ S T S+ E+E L
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 1196 NKDIENLR------REREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAV 1249
K ENL +ER++L E ++ER ++E K E+Q++L + +
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSK 1934
Query: 1250 RQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIEN 1309
E ++ L+ +++E ++ Q + K +L K Q L+ + ++++ D +
Sbjct: 1935 EHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHK 1994
Query: 1310 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1346
E + E ++S+ QL + +++ L
Sbjct: 1995 KINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL 2031
Score = 158 bits (400), Expect = 3e-38
Identities = 282/1435 (19%), Positives = 603/1435 (42%), Gaps = 222/1435 (15%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKK----KNKKKEIQNGNL--HESDSESVPR 82
++E L ++ Q+++Q+L+ + + + +KK +N K E++N L ++E +
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLEL 1184
Query: 83 DFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQ-----VIKESDASK 137
KL++ N E S +ERK ++ QK E+ I+E +A+
Sbjct: 1185 AQKLNE--------------NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATG 1230
Query: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH 197
+ K+ + ++ +K ++ + +K T K QE +P+
Sbjct: 1231 LQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHT-----KLQEEIPVL 1285
Query: 198 QETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKP 257
E ++ + K+ + +++ E + E +TT D+ + + +R ++
Sbjct: 1286 HEEQELLPNVKEVSETQETMNELELLTE---QSTT----KDSTTLARIEMERLRLNEKFQ 1338
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVK-------FKDFLLSLKTMMFSEDEALCVVDLLKE 310
+ E I+ ++ +T KE EVK ++ L ++ ++++L + + E
Sbjct: 1339 ESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNE 1398
Query: 311 KSGVIQDALKKSSKG--------ELTTLIHQLQEK-DKLLAAVKEDAAATKDRCKQLTQE 361
+ ++ + + K E+ L +LQE D++ + KE KD ++L +
Sbjct: 1399 TTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-----KDDLQRLQEV 1453
Query: 362 MMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVR---EQMEAE 418
+ +E ++ +K+ I + +H + ++ V++ ++ + ++R + E E
Sbjct: 1454 LQSESDQ-------LKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETE 1506
Query: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
I+ ++++ + D + N ++ K+ Q + ++E+ EK +L+Q + +K
Sbjct: 1507 ISTIQKQLEAINDKLQNKIQEIYEKEE-------QFNIKQISEVQEKVNELKQFKEHRKA 1559
Query: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
+ A ++ ++ E R +E Q I+ E E ++ +Q + ++++ ++
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKR-VQEALQIERDQLKENTKEIVA 1618
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
+ Q+ E + +++ VN+ + +++ + EQ E K ++ ++ T
Sbjct: 1619 KMKESQEKEYQFLKMTA-----VNETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQI 1673
Query: 599 -SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS-----------KEEELKDIQNMNFL 646
EE+ V E+D ++ E++L ERD+L K+EELK +
Sbjct: 1674 LHENLEEMRSVTKERD-DLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKE 1732
Query: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
+ + KL+ + +E+ +E+ MQ+ + +D ++ + ++Q EE +I +
Sbjct: 1733 HQETIDKLRGIVSEKT---NEISNMQKDLEHSNDALKAQDLKIQ-------EELRIAHMH 1782
Query: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELN 766
K + + KL+ +VSE+ +K + M+K ++ + KL+ + L+ Q+ T ++++N
Sbjct: 1783 LKEQQETIDKLRGIVSEKTDK--LSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVN 1840
Query: 767 AIRTENSSLTKEVQDLKAKQNDQVSFASLVE----ELKKVIHEKDGKIKSVEELLEAELL 822
E E++ LK + DQ S +E L + +HE ++KSV + +
Sbjct: 1841 ----ETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERD---- 1892
Query: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAV 882
N + + LK E LKE + Q KA+ L I +++ + L K +E ++ ++
Sbjct: 1893 ---NLRRVEETLKLERDQLKESL---QETKARDLEIQQELKTARMLSKEHKETVDKLREK 1946
Query: 883 LEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENEL 942
+ EK +++ K DL + + L+ +QE+ + L+ + E E
Sbjct: 1947 ISEKTIQISDIQK---DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLK 2003
Query: 943 KRLEAMLKERES---DLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK 999
K+ EA +S D T+ L + +E ++ + ++L++ L+
Sbjct: 2004 KQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLR 2063
Query: 1000 VISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQ--DKVNKT 1057
+ R+++ + E L D +H + LREK E L +M + +N+
Sbjct: 2064 EMIARDRQNHQVKPEKRLLSDGQQHLTES---LREKCSRIKELLKRYSEMDDHYECLNRL 2120
Query: 1058 SKERQQQVEAVELEAKEVLKKLFPKVSVP------------SNLSYGEWLHGFEKKAKEC 1105
S + ++++E KE+ ++ +S+P +N H KK K
Sbjct: 2121 SLDLEKEIEF----QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYV 2176
Query: 1106 MAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ-RSVEQEENKW 1164
++ + ++K +H+ EM + E EK K +L + + + Q S E + K
Sbjct: 2177 LSYVT---KIKEEQHESINKFEMDFID--EVEKQKELLIKIQHLQQDCDVPSRELRDLKL 2231
Query: 1165 KVKVDESHKTIKQ--MQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKA------ 1216
+D + I + +S F S + E +++ S K++ E + ++EK
Sbjct: 2232 NQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQK 2291
Query: 1217 EMERSTYVT------------EVRELKDLLTELQKKLDDSYSEAVRQNEEL----NLLK- 1259
E +R V E E ++ + K+ + +NE+L LK
Sbjct: 2292 ENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKT 2351
Query: 1260 -----AQLNETL------------TKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAG 1302
AQ+N T T+L TE+ +++ LH+A++S +SKI+K
Sbjct: 2352 SLASGAQVNPTTQDNKNPHVTSRATQLTTEKI--RELENSLHEAKESAMHKESKIIKMQK 2409
Query: 1303 DTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ V N + +LQ + N+ L K KE QVL+
Sbjct: 2410 ELEV---------------------TNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Score = 150 bits (379), Expect = 8e-36
Identities = 248/1229 (20%), Positives = 530/1229 (43%), Gaps = 208/1229 (16%)
Query: 297 SEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK---D 353
S DEAL LK I D K+ + L T Q EKD+L ++E K +
Sbjct: 339 STDEAL-----LKRYRKEIMDLKKQLEEVSLETRA-QAMEKDQLAQLLEEKDLLQKVQNE 392
Query: 354 RCKQLTQEMMTE---------KERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQ-ETQQ 403
+ + LT+ ++T K + +T +I ++ + Q I + +T +
Sbjct: 393 KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHK 452
Query: 404 MQMKF-QQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS--AELNKLRQDYARLVN 460
+ + +++ E + +E L + N +L ++++ +ELN LR DY LV
Sbjct: 453 LSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLV- 511
Query: 461 ELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQ-----SYIRKRTAEHEAAQ 515
L + + ++EE++ K E+ L+ ++ +E+Q S ++ E
Sbjct: 512 -LDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYN 570
Query: 516 QDLQSKFVAK-------------------ENEVQSLHSKLTDTLVSKQQLEQRLMQLMES 556
QDL+++ +K +++++ L+ +L S + +Q L ++
Sbjct: 571 QDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDA 630
Query: 557 EQKRVN-KEES---------LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV-LAEEL 605
E ++ K ES L+ +++++ + ++ IQ + SQ+ A+ V L +EL
Sbjct: 631 ETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKEL 690
Query: 606 HKVIAEKDKQIKQTEDSLASE-------RDRLTSKEEELKDIQNMNFLLKAEVQKLQALA 658
E K + + + ++T ++EL N L+ EV L
Sbjct: 691 QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV----ILL 746
Query: 659 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQ-----------------LQHEISNKMEEFK 701
+E + E+E++++ + K +++ ++ + L EI ++
Sbjct: 747 SELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLA 806
Query: 702 ILNDQNKALKSEVQKLQTLVS--EQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
K+ E Q +TL EQ K V+E+ E+ QE K ++
Sbjct: 807 TTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKF--------- 857
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE---L 816
+ L A++TE S T+E+Q+ + +++ + +E+LK+ + +D +++VE L
Sbjct: 858 --DSSLGALKTELSYKTQELQEKTREVQERL---NEMEQLKEQLENRDSTLQTVEREKTL 912
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQ-----------QLSITSKVQEL 865
+ +L + + KT+ K ++K L+E ++Q+E+ Q + +++
Sbjct: 913 ITEKLQQTLEEVKTLTQEKDDLKQLQE---SLQIERDQLKSDIHDTVNMNIDTQEQLRNA 969
Query: 866 QNLLKGKEEQMNTMKA-VLEEKEKDL---ANTGKWLQDLQ------EENESLKAHVQEVA 915
LK +E +NT+K+ + EE ++L NTG+ + Q ++ + L+A +
Sbjct: 970 LESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTL 1029
Query: 916 QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE---SDLSSKTQLLQDVQDENKL 972
++K+ Q ++ +++EK + LE+++ E+E +DL ++ + Q+E +L
Sbjct: 1030 TADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRL 1089
Query: 973 FKSQIEQLKQQNYQQASSFPPHE-----------ELLKVISEREKEISGLWNELDSLKDA 1021
++++ ++ Q+ + E E+ + + E+ +++ +L ++++
Sbjct: 1090 LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEE 1149
Query: 1022 VEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSK--ERQQQVEAVELEAKEVLKKL 1079
+ +KK N++ E + E M +++ K E ++V+++ E K VLK+L
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERK-VLKEL 1208
Query: 1080 FPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKY 1139
+ L G+ ++ + G EE+K+ LKE E L+ +
Sbjct: 1209 QKSFETER-----DHLRGYIREIE--ATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
Query: 1140 KSVLAETEGILQ---KLQRSV----EQEENKWKVK-VDESHKTIKQMQ---------SSF 1182
+ + T+ + + KLQ + E++E VK V E+ +T+ +++ S
Sbjct: 1262 TAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDST 1321
Query: 1183 TSSEQELERLRSENK------DIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
T + E+ERLR K +I++L +ER++L+ E E++ +RE + E
Sbjct: 1322 TLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQE 1381
Query: 1237 LQKKLDDSYSEAVRQNEELNL----------------LKAQLNETLTKLRTEQNERQKVA 1280
Q K + S + + NE + ++ ++ +L+ +E + VA
Sbjct: 1382 SQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVA 1441
Query: 1281 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE--------SSEKETMS---VSLN 1329
+ Q+ E++QS+ + + I + E E ++ET++ V+L+
Sbjct: 1442 KEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLS 1501
Query: 1330 QTVTQ---LQQLLQAVNQQL-TKEKEHYQ 1354
+ T+ +Q+ L+A+N +L K +E Y+
Sbjct: 1502 EKETEISTIQKQLEAINDKLQNKIQEIYE 1530
Score = 112 bits (280), Expect = 2e-24
Identities = 230/1159 (19%), Positives = 485/1159 (41%), Gaps = 199/1159 (17%)
Query: 57 AEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKK 116
A+ ++++ K+ Q+ N+ E D+E+ ++ + +D + + + ++ S ++E
Sbjct: 1377 AKIQESQSKQEQSLNMKEKDNETTKIVSEM-EQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 117 ------KEKKQKPVLEEQVIKESDASKIPGKKV--------EPVPVTKQPTPPSEAAASK 162
KEK L+E + ESD K K++ E + V E ++
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINE 1495
Query: 163 KKPGQKKSKNGSDDQDKKVETL--MVPSKRQEALPLHQETK-QESGSGKKKASSKKQKTE 219
+ + + K++E + + +K QE ++ ++ ++K + KQ E
Sbjct: 1496 LRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKE 1555
Query: 220 N--------VFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQ-KSGTKK 270
+ ++ ++ T + + +K E+ + + Q+E Q K TK+
Sbjct: 1556 HRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKE 1615
Query: 271 LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALK--KSSKGELT 328
+ + KE+ E K++ T + E +C ++ LKE+ + L+ ++ LT
Sbjct: 1616 IVAKM-KESQE---KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETENIRLT 1671
Query: 329 TLIHQ--------LQEKDKLLAAVKEDAAATKDRCKQLTQEMMT----EKERSNVVITRM 376
++H+ +E+D L +V+E +D+ K+ +E +T ++E +V +
Sbjct: 1672 QILHENLEEMRSVTKERDDL-RSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHL 1730
Query: 377 KDRIGTLEKEHNVFQNKIHVSYQETQQMQ-----MKFQQVREQMEAEIAHL---KQENGI 428
K+ T++K + K + + ++ +K Q ++ Q E IAH+ +Q+ I
Sbjct: 1731 KEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETI 1790
Query: 429 --LRDAVSNTTNQLESKQSAELN---KLRQDYARL-------------VNELTEKTGKLQ 470
LR VS T++L + Q N KL++ L VNE +K +++
Sbjct: 1791 DKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEME 1850
Query: 471 QEEVQKKNAEQAATQLKVQ----LQEAERRWEEVQSYIRKRT----------AEHEAAQQ 516
Q + Q K+ ++L+++ Q+ EE++S +++R E + ++
Sbjct: 1851 QLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE 1910
Query: 517 DLQ---------------SKFVAKENE--VQSLHSKLTDTLV-----------SKQQLEQ 548
LQ ++ ++KE++ V L K+++ + SK +L++
Sbjct: 1911 SLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQK 1970
Query: 549 RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELH-- 606
++ +L + E + + +E + M + I E + K Q S + + L ++LH
Sbjct: 1971 KIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHES 2030
Query: 607 ----KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKL----QALA 658
+++A++ ++++ ++SL ERD+ + E+ N +K E + L Q L
Sbjct: 2031 LEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLT 2090
Query: 659 NEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS------ 712
++++ + DD L +L ++ ++E K L+ + KA S
Sbjct: 2091 ESLREKCSRIKELLKRYSEMDDHYECLN-RLSLDLEKEIEFQKELSMRVKANLSLPYLQT 2149
Query: 713 -EVQKLQTLVSE---------QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
++KL T + K V+ + K +E+ E + E I K+
Sbjct: 2150 KHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINK----FEMDFIDEVEKQ 2205
Query: 763 EEL----NAIRTENSSLTKEVQDLKAKQN------------DQVSFASLVEELKKVIHEK 806
+EL ++ + ++E++DLK QN + F S+ E ++V+ +
Sbjct: 2206 KELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNR 2265
Query: 807 DGKIKSVEELLEA--ELLKVANKEKTVQDLKQEIKALKEE----IGNVQLEKAQQLSITS 860
+ +EE L ++ K+ N + D ++ I N E ++ + S
Sbjct: 2266 KEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATIS 2325
Query: 861 KVQELQNL--LKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA------HVQ 912
K E Q+L LK K E++ L+ A QD + + + +A ++
Sbjct: 2326 KEWE-QDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIR 2384
Query: 913 EVAQHNLKEASSASQFEELEIVLKEKENE-----LKRLEAMLKERESDLSSKTQLLQDVQ 967
E+ +++L EA ++ +E +I+ +KE E + +L+A + E L + +Q +Q
Sbjct: 2385 EL-ENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQ 2443
Query: 968 DENKL----FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
D+ L +K +IE LK + L+K+ E+ K E+ + K VE
Sbjct: 2444 DKVALGAKPYKEEIEDLKMK-------------LVKIDLEKMKNAKEFEKEISATKATVE 2490
Query: 1024 HQRKKNNDLREKNWEAMEA 1042
+Q++ LRE + +A
Sbjct: 2491 YQKEVIRLLRENLRRSQQA 2509
Score = 105 bits (263), Expect = 2e-22
Identities = 170/932 (18%), Positives = 405/932 (43%), Gaps = 144/932 (15%)
Query: 480 EQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDT 539
E + + ++ + +++ EEV R + E + Q L+ K + ++ + + + + LT
Sbjct: 342 EALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN-LTRM 400
Query: 540 LVSKQQLEQRLMQLMESEQKR--------VNKEESL-----------------QMQVQDI 574
LV+ L L Q +++++KR +NK ++ ++ + +
Sbjct: 401 LVTSSSLT--LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLL 458
Query: 575 LEQNEALKAQIQQFH------SQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD 628
E +E++ ++ F S+I + +L +E I + ++ D+L + +
Sbjct: 459 REIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN---IESELNSLRADYDNLVLDYE 515
Query: 629 RLTSKEEELK-DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEE 687
+L +++EE++ ++ N L + E + + +++ HE+ ++ V + +
Sbjct: 516 QLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV----KHAEVYNQ 571
Query: 688 QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTV 747
L++E+S+K+E + DQ ++KLQ + Q +++ + ++ ++ +
Sbjct: 572 DLENELSSKVELLREKEDQ-------IKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMK 624
Query: 748 EELLETGLIQVATKEEELNAIRTENSSLTKEVQDL----KAKQNDQVSFASLVEELKKVI 803
+ L + + + K E +R+EN L +++++L K +ND + S +E KK+
Sbjct: 625 QTLFDAETVALDAKRESA-FLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 804 HEKDGKIKS-----------VEELLEAELLKVANKEKTVQDLKQEI-------KALKEEI 845
+ + +++S ++ + +LL E + DL++E+ +AL+EE+
Sbjct: 684 VDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEV 743
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
+ ++ S+ S+V+ L+ ++ K E+++ + + ++ ++ + +Q L EE
Sbjct: 744 ----ILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIG 799
Query: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
K + Q N K S+ +F+ + + + E + K + L+E E Q + +
Sbjct: 800 KTKDDLA-TTQSNYK--STDQEFQNFKTLHMDFEQKYKMV---LEENER----MNQEIVN 849
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
+ E + F S + LK + S+ E + E+ +E+ NE++ LK+ +E++
Sbjct: 850 LSKEAQKFDSSLGALKTE-----LSYKTQE-----LQEKTREVQERLNEMEQLKEQLENR 899
Query: 1026 RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSV 1085
+ + E L T + ++ + +Q Q E++++E ++ + V++
Sbjct: 900 DSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQ-ESLQIERDQLKSDIHDTVNM 958
Query: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145
N+ E L + K+ E + L+ K+ E
Sbjct: 959 --NIDTQEQLRNALESLKQ------HQETINTLKSKISE--------------------- 989
Query: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRE 1205
++ R++ EEN + K DE + + + + + L ++ KD E + ++
Sbjct: 990 ------EVSRNLHMEENTGETK-DEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQ 1042
Query: 1206 REHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
R+ + EK E+++ + + E + L T+L++ ++ + + EEL LL +L +
Sbjct: 1043 RKIFSLIQEKNELQQMLE-SVIAEKEQLKTDLKENIEMT----IENQEELRLLGDELKKQ 1097
Query: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS 1325
+ E+N K G+L + L ++ K+ + + + ++ + E SE +
Sbjct: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 1326 VSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ +L+ N++LT E + LE
Sbjct: 1158 NEIENLKNELK------NKELTLEHMETERLE 1183
Score = 80.9 bits (198), Expect = 8e-15
Identities = 194/1073 (18%), Positives = 432/1073 (40%), Gaps = 157/1073 (14%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDD 95
+++ K+K E K + ++ + K+N K+ + ES ++++ AV +
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMK------ESQEKEYQFLKMTAVNET 1639
Query: 96 QVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPV-PVTKQPTP 154
Q E + K++ + QK LE + ++I + +E + VTK+
Sbjct: 1640 Q---------EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDD 1690
Query: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
+ K + +N + + +E K++E +H K+ + K
Sbjct: 1691 LRSVEETLKVERDQLKENLRETITRDLE------KQEELKIVHMHLKEHQETIDKLRGIV 1744
Query: 215 KQKTENVF-VDEPLIHATTYIPLMD-------NADSSPVVDKREVIDLLKPDQVEGIQKS 266
+KT + + + L H+ + D + +++E ID L+ GI
Sbjct: 1745 SEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLR-----GIVSE 1799
Query: 267 GTKKLKT-ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
T KL + D EN+ K ++ + LK +E + ++ L K+ + + KK S
Sbjct: 1800 KTDKLSNMQKDLENSNAKLQEKIQELKA---NEHQ---LITLKKD----VNETQKKVS-- 1847
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E+ L Q++++ L+ ++ + + + +EM + + + +D + +E+
Sbjct: 1848 EMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS--------VMKERDNLRRVEE 1899
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQS 445
+ ++++ S QET+ ++ QQ + K+ LR+ +S T Q+ Q
Sbjct: 1900 TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQK 1959
Query: 446 AELNKLRQDYARLVNELTEKTGKL---------------QQEEVQKKNAEQAATQLKVQL 490
+L+K + + + + EL +K +L + E+++K+ Q + V++
Sbjct: 1960 -DLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRM 2018
Query: 491 QEAE--RRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQ-QLE 547
+ ++ E IR E + ++ +S + ++ + +L + + Q + E
Sbjct: 2019 DNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPE 2078
Query: 548 QRLMQ-----LMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
+RL+ L ES +++ ++ + L + ++ + E L +I Q S+
Sbjct: 2079 KRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRV 2138
Query: 603 EELHKVIAEKDKQIKQ---TEDSLASERDRLTSK------------EEELKDIQN--MNF 645
+ + + K I++ + E R+ K EE+ + I M+F
Sbjct: 2139 KANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDF 2198
Query: 646 LLKAEVQK-----LQALANEQAAAAHELE--KMQQSVYVKDDKIRLLEEQLQHEISNKME 698
+ + E QK +Q L + + EL K+ Q++ + ++I L++ + E +
Sbjct: 2199 IDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEI--LKDFSESEFPSIKT 2256
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
EF+ + L + + Q L + +E+++ IQ++++++ V +I +
Sbjct: 2257 EFQ------QVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAI 2310
Query: 759 ATK---------------EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK--- 800
+ E++L +++ +N L K Q LK ++ K
Sbjct: 2311 MNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPH 2370
Query: 801 ---KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS 857
+ KI+ +E L +KE + +++E++ + I +Q + +
Sbjct: 2371 VTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNK 2430
Query: 858 ITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKA 909
K +E +L+ K +E++ +K L + + + K + ++E + KA
Sbjct: 2431 CLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAK---EFEKEISATKA 2487
Query: 910 HV--QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ 967
V Q+ L+E SQ + V+ E + + + S + T+ L ++
Sbjct: 2488 TVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKAL-ILK 2546
Query: 968 DENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKD 1020
E+ + +I +LKQQN E+L+K +E L NE+ + K+
Sbjct: 2547 SEHIRLEKEISKLKQQN----------EQLIKQKNELLSNNQHLSNEVKTWKE 2589
Score = 57.4 bits (137), Expect = 9e-08
Identities = 143/711 (20%), Positives = 290/711 (40%), Gaps = 95/711 (13%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNK----KKEIQNGNLHESDSESVPRD-F 84
K+ L ++ QK+E +L+ K D + KK N+ KK+ + NL +SV D F
Sbjct: 1965 KDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNL---SMQSVRMDNF 2021
Query: 85 KLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQK-PVLEEQVIKESDASKIPGKKV 143
+L+ L +++ V E ++E K E+ Q L E + ++ ++ +K
Sbjct: 2022 QLTKKLHESLEEIRIVAKERDELRR-IKESLKMERDQFIATLREMIARDRQNHQVKPEKR 2080
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSD----------DQDKKVETLMVPSKRQEA 193
+ T S+ K K+ D D +K++E S R +A
Sbjct: 2081 LLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKA 2140
Query: 194 ---LPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE 250
LP Q E K ++++ E + + L + +Y+ + ++ E
Sbjct: 2141 NLSLPYLQTKHIE----KLFTANQRCSMEFHRIMKKLKYVLSYVTKIKE-------EQHE 2189
Query: 251 VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKE 310
I+ + D ++ ++K +K + +++ +V ++ L+ + +++ L + ++LK+
Sbjct: 2190 SINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRE----LRDLKLNQNMDLHIEEILKD 2245
Query: 311 KSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSN 370
S +S + T Q+ K + E+ T+ ++L + E +R
Sbjct: 2246 FS--------ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRIC 2297
Query: 371 VVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILR 430
V +N F N+I E+ + + + + ++ E ++ LK++N L
Sbjct: 2298 QV--------------NNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLF 2343
Query: 431 DAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQL 490
L S A++N QD +T + +L E+++ +L+ L
Sbjct: 2344 KNYQTLKTSLAS--GAQVNPTTQDNKN--PHVTSRATQLTTEKIR---------ELENSL 2390
Query: 491 QEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL 550
EA+ +S I K E E D+ +K AK +E K +T+ ++
Sbjct: 2391 HEAKESAMHKESKIIKMQKELEVT-NDIIAKLQAKVHESNKCLEKTKETI--------QV 2441
Query: 551 MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIA 610
+Q + + KEE ++++ + E +K ++F +I+A + +E+ +++
Sbjct: 2442 LQDKVALGAKPYKEEIEDLKMKLVKIDLEKMK-NAKEFEKEISATKATVEYQKEVIRLLR 2500
Query: 611 EKDKQIKQTED-SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
E ++ +Q +D S+ SE T + K + + K L +E E+
Sbjct: 2501 ENLRRSQQAQDTSVISEH---TDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEIS 2557
Query: 670 KM-QQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
K+ QQ+ + K LL QH +SN+++ +K + LK E K T
Sbjct: 2558 KLKQQNEQLIKQKNELLSNN-QH-LSNEVKTWK-----ERTLKREAHKQVT 2601
Score = 47.4 bits (111), Expect = 1e-04
Identities = 109/556 (19%), Positives = 222/556 (39%), Gaps = 136/556 (24%)
Query: 921 EASSASQFEELEIVLKEKE--NELKRLEAMLKERESDLSSKTQLLQDVQDENK---LFKS 975
E +A QF +K NE+ EA+LK ++ + L++V E + + K
Sbjct: 315 ETLTALQFASTAKYMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKD 374
Query: 976 QIEQL--------KQQNYQ---------QASSFPPHEELLKVISEREKEISGLWNELDSL 1018
Q+ QL K QN + +SS +EL ++R++ ++ +++ +
Sbjct: 375 QLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELK---AKRKRRVTWCLGKINKM 431
Query: 1019 KDA--------------VEHQRKKN--------------------NDLREKNWEAMEALA 1044
K++ H+ N + L E W L
Sbjct: 432 KNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLL 491
Query: 1045 STEKMLQDKVNKTSKERQQQV---EAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1101
+ E ++ ++N + V E + E +E+ KL K ++L E L KK
Sbjct: 492 NQEN-IESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEK----NDLDEFEALERKTKK 546
Query: 1102 AKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE 1161
+E E+ L++ +K A+ + L+ E +L E E ++KLQ ++ ++
Sbjct: 547 DQEMQL----IHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQK 602
Query: 1162 NKWKVKVD-----ESHKTIKQMQSSFTSSE-------QELERLRSENKDIENLRRE---- 1205
+ +K+D ES + KQM+ + +E +E LRSEN +++ +E
Sbjct: 603 LE-NIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATT 661
Query: 1206 -----------------REHLEMELEKAEMERSTYVTEVREL------KDLL-------- 1234
++ ++++LEK +T++ L KDLL
Sbjct: 662 YKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721
Query: 1235 -TELQKKLDDSY--SEAVRQN-----------EELNLLKAQLNETLTKLRTEQNERQKVA 1280
T+LQK+L+ +EA+R+ E+ L+ ++ + +L +E+ K+
Sbjct: 722 ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781
Query: 1281 GDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ 1340
++ + ++ + +I K D +++ S + E +T+ + Q + + +
Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841
Query: 1341 AVNQQ---LTKEKEHY 1353
+NQ+ L+KE + +
Sbjct: 842 RMNQEIVNLSKEAQKF 857
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 176 bits (447), Expect = 1e-43
Identities = 311/1481 (20%), Positives = 631/1481 (42%), Gaps = 209/1481 (14%)
Query: 31 ETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL 90
ETL E L K ++Q ++ K + E +K + +E+++ + E + + + DAL
Sbjct: 23 ETLPKEDLIKFAKKQMMLIQKAKSRCTELEK-EIEELRSKPVTEGTGDIIKALTERLDAL 81
Query: 91 AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASK------------I 138
+E ET KK+ K K +E+ V K DA K I
Sbjct: 82 LLEK----------AETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEI 131
Query: 139 PGKKVEPVPVTKQPTPPSEAAASKKKP------------GQKKSKNGSDDQDKKVETLMV 186
K E + V + SE A+ +K Q K +N S+D KK++ +
Sbjct: 132 ENLKNELMAVRSKY---SEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 187 ---PSKRQEALPLHQETKQESGSGKKKA----------SSKKQKTENVFVDEPL----IH 229
P ++ L L ++ + K+ S QK N +E L IH
Sbjct: 189 KIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIH 248
Query: 230 ATTYIPLMDNADSSPVVDKREVIDL--LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDF 287
LM ++S + E+ L LK + V+ + E ++N + K++
Sbjct: 249 QEEVKELMCQIEASAKEHEAEINKLNELKENLVK----------QCEASEKNIQKKYECE 298
Query: 288 LLSLK--TMMFSEDEALC---------VVDLLKEKSGVIQDALKKSS------KGELTTL 330
L +L+ T ++D +C V ++ EK ++D LK+ K E+T +
Sbjct: 299 LENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYM 358
Query: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVF 390
+ + + +K++ ++ + E++ KE VI ++K + L K+ F
Sbjct: 359 NNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQ---F 415
Query: 391 QNKIHVSYQETQQMQMKFQ-QVREQMEAEIAHLKQENGILRDAVSNTTNQLES----KQS 445
+ +E Q ++ + Q ++ E E ++ ++E L + Q E+ KQ
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 446 AELN--KLRQDYARLVNELTEKTGKLQQE-EVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
A LN LR+ L EL E GK+ QE E K+ +L+ +L+ A + +
Sbjct: 476 AILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLE 535
Query: 503 YIRKRTAEHEA--AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL------- 553
+ + E+E +QQ+L + EN +++L K L+S Q + L +L
Sbjct: 536 TVNRLQGENEKLLSQQELVPEL---ENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSL 592
Query: 554 -----------------MESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
M++ K+ +EE L +++ +EQ ++++Q +++
Sbjct: 593 TEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGL 652
Query: 597 SASVLAEELH-----------KVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDI---- 640
++ ++ + KV++E + + SL E ++L+S++++L +D+
Sbjct: 653 EETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFL 712
Query: 641 -QNMNFLLKAEV----QKLQALANEQAAAAHELEKMQ-QSVYVKDDKIRLLEEQLQHEIS 694
Q + +LK + +KLQ + EQ LE Q Q ++VK L+E + E+S
Sbjct: 713 SQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKE-MGSEVS 771
Query: 695 NKMEEFKILNDQNKALKS--EVQKLQTLVSEQPNKDVVEQME--KCIQEKDE-KLKTVEE 749
EE ++N +S ++ + + ++ Q ++ V+E + KC+QE+ + + ++
Sbjct: 772 EDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKS 831
Query: 750 LLETGLIQVATKEEELNAIRTENSSLTKEVQDLK-AKQNDQVSFASLVEELKKVIHE-KD 807
LL + +EL I++E +L ++ ++K A + ++ +L+ ++++V
Sbjct: 832 LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSK 891
Query: 808 GKIKSVEE---LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLS----ITS 860
+I + +E + E E LK ++K ++D + E+ LK+ + K LS +
Sbjct: 892 SEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEE 951
Query: 861 KVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK 920
K++ L+ K KEE++N +K V + +K+L ++ K Q ++EE ESL++ +++
Sbjct: 952 KIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRD 1011
Query: 921 EASSASQFEELEIVLKEKENEL-------KRLEAMLKERESDLSSKTQLLQDVQDENKLF 973
A ++ L + +++ +L E +++ L + T + + +N+
Sbjct: 1012 LIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDL 1071
Query: 974 KSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR 1033
++IE L Q N + + K + ++E E L E ++ N+L
Sbjct: 1072 LARIETL-QSNAKLLEVQILEVQRAKAMVDKELEAEKLQKE-----QKIKEHATTVNELE 1125
Query: 1034 EKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEA---KEVLKKLFPKVSVPSN-L 1089
E + + +K +Q+ + K+ QQ + +E + ++K+L K++ +N +
Sbjct: 1126 ELQVQLQKEKKQLQKTMQEL--ELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKI 1183
Query: 1090 SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT-----LLQLECEKYKSVLA 1144
E +K+ +E + EE+ L+ +++ +E +T L++ + E S A
Sbjct: 1184 EDLEQEIKIQKQKQETL-----QEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQA 1238
Query: 1145 ETEGILQKLQRSVEQEENKWKVKV---------DESHKTIKQMQSSFTSSEQELERLRSE 1195
ET+ ++ + E E ++ +V+V E HK + ++ TS+EQ L +
Sbjct: 1239 ETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLK---TSAEQHQRTLSAY 1295
Query: 1196 NKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEEL 1255
+ + L+ E + E E +Y V + L + K + + +E +Q E
Sbjct: 1296 QQRVTALQEECRAAKAEQATVTSEFESYKVRVHNV--LKQQKNKSMSQAETEGAKQERE- 1352
Query: 1256 NLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1315
L+ +++ KL+ QN Q +L Q + + + K + TV + +++ +
Sbjct: 1353 -HLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQE-TVSKEAELREK 1410
Query: 1316 TESSEKETMSVSL--NQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
S + E M + QTV+QL + + + H Q
Sbjct: 1411 LCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQ 1451
Score = 94.0 bits (232), Expect = 9e-19
Identities = 163/887 (18%), Positives = 377/887 (42%), Gaps = 96/887 (10%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRE 113
+K+ E+ +++K+ +Q+ L ++ R + + VE+ V +T S
Sbjct: 844 RKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEE---------VSQTCSKSEI 894
Query: 114 RKKKEK-------KQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPG 166
+KEK KP+LE++ +++ A I K + K P+ ++ +S K+
Sbjct: 895 HNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKD----SLAKSPSVKNDPLSSVKELE 950
Query: 167 QKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEP 226
+K + ++K+ K + + + K+E S +K+ + K++ E++ ++
Sbjct: 951 EKIENLEKECKEKE-------EKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKD 1003
Query: 227 LIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKD 286
+ A+ L+ A+S K +++ K + ++K + E+ + ++
Sbjct: 1004 QLSASMR-DLIQGAESY----KNLLLEYEKQSEQLDVEKERANNFEHRI--EDLTRQLRN 1056
Query: 287 FLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVK- 345
L +T+ ++ L ++ L+ + +++ + + + + ++ + E +KL K
Sbjct: 1057 STLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAK--AMVDKELEAEKLQKEQKI 1114
Query: 346 EDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE----- 400
++ A T + ++L ++ +KE+ + T + + + + N Y+
Sbjct: 1115 KEHATTVNELEEL--QVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKEL 1172
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVN 460
Q++ K ++ E +E EI KQ+ L++ +++ + ++ + K++Q +
Sbjct: 1173 NQKLTNKNNKI-EDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKN-TKIKQLLVKTKK 1230
Query: 461 ELTE----KTGKLQQEEVQKKNAEQAATQL---KVQLQEAERRWEEVQSYIRKRTAEHEA 513
EL + +T L + K E + Q+ K+QL E ++ +++ +H+
Sbjct: 1231 ELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQR 1290
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
Q + A + E ++ ++ + + R+ +++ ++ NK S Q + +
Sbjct: 1291 TLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK---NKSMS-QAETEG 1346
Query: 574 ILEQNEALKAQIQQFHSQIA-AQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTS 632
++ E L+ I Q ++ +Q + + EL + +E D +++ L +
Sbjct: 1347 AKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE 1406
Query: 633 KEEELKDIQNMNFLLKAE-VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH 691
E+L IQ+ N ++K+E Q + L ++ + D++R L+E+ +
Sbjct: 1407 LREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR----------DQVRHLQEEHRK 1456
Query: 692 EISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ ++ + Q LK+E + S+Q K++ E+ + D T EE
Sbjct: 1457 TVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREE-- 1514
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
G T E +++ T SL + + + K + A +E +++ + K
Sbjct: 1515 --GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKE--ELVQKLSSTTK 1570
Query: 812 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLL-- 869
S + L LL+ E T L ++IK LK EI ++ + ++ S + ++ L+N+L
Sbjct: 1571 SADHL--NGLLR--ETEATNAILMEQIKLLKSEIRRLERNQEREKS-AANLEYLKNVLLQ 1625
Query: 870 -----KGKEEQ-----MNTMKAVLEEKEKDLANTGKWLQDLQEENES 906
G E + +NTM + E++ LA + +EEN S
Sbjct: 1626 FIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQG----EEENAS 1668
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 175 bits (444), Expect = 2e-43
Identities = 231/1132 (20%), Positives = 495/1132 (43%), Gaps = 172/1132 (15%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q L+ E++ L +
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---M 1435
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG----------- 894
+V+ A ++ K + +L +++ A LE +K+ + G
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 895 ---KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E
Sbjct: 1496 ESLDQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
E+ L + + +Q E KS++++ + ++ + ++++ + +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA- 1609
Query: 1012 WNELDSLKDAVEHQRKKNNDLRE----------------KNWEAMEALASTEKMLQDKVN 1055
E+ S DA+ ++K DL E +N+ + + ++ D
Sbjct: 1610 --EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667
Query: 1056 KTSKERQQQVEAVELEAK------EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1109
++ ++ ++Q+ VE A E L+ + ++ E L E+ T
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 1110 SGSEEVKVLEHKLKEAD-EMHTLLQLEC---EKYKSVLA-------------ETEGILQK 1152
S K LE + + EM +LQ EK K + +T L++
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 1153 LQRSVEQEENKWKVKVDESH--------KTIKQMQSSFTSSEQELERLRSENKD-IENLR 1203
+++++EQ ++++DE+ K I+++++ E E+E + N + ++ LR
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 1204 REREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLN 1263
+ ++ + E +R + L+DL+ +LQ K+ SY + EE Q N
Sbjct: 1848 KHERRVKELTYQTEEDRK----NILRLQDLVDKLQAKV-KSYKRQAEEAEE------QSN 1896
Query: 1264 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1315
L K R Q+E L +A++ ++ +S++ K + + +S E
Sbjct: 1897 TNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 132 bits (332), Expect = 2e-30
Identities = 175/788 (22%), Positives = 350/788 (44%), Gaps = 106/788 (13%)
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ---------FHSQIAAQTSASV 600
L++ E+E++ +E Q +++D L ++EA + ++++ Q+ Q A
Sbjct: 845 LLKSAETEKEMATMKEEFQ-KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEG 903
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LA+ E+ Q+ +T+ L ++ +T + E D + +N L A+ +KL+ +E
Sbjct: 904 LAD-----AEERCDQLIKTKIQLEAKIKEVTERAE---DEEEINAELTAKKRKLEDECSE 955
Query: 661 QAAAAHELE----KMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQNKA---- 709
+LE K+++ + ++K++ L E+ L I+ +E K L + ++
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 710 LKSEVQKLQTLVS-----EQPNKDV---VEQMEKCIQEKDEKLKTVEELLETGLIQVATK 761
L++E K+ TL EQ D+ +EQ +K + + + +E L+ +
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 762 EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL 821
E E + + E+ +L++K D+ +L +L+K I E +I+ +EE +EAE
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEELEEEIEAER 1132
Query: 822 LKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEE---QMN 877
A EK DL +E++ + E + + Q+ + K + E Q + + EE Q
Sbjct: 1133 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1192
Query: 878 TMKAVLEEKEKD--------LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929
A L +K D + N + Q L++E +K + ++A + + + E
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLE 1252
Query: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ-------DENKLFKSQIEQLKQ 982
++ L+++ +ELK E + +DL+++ LQ DE + SQ+ + KQ
Sbjct: 1253 KMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ 1312
Query: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042
QQ EEL + + E K + L + L S + + R++ + +E E A
Sbjct: 1313 AFTQQI------EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA 1366
Query: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1102
L+ + K + Q+ E +E EAK+ L + L E+
Sbjct: 1367 LSKANTEVAQWRTKYETDAIQRTEELE-EAKKKL---------------AQRLQAAEEHV 1410
Query: 1103 KECMAGTSGSEEVKV-LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE 1161
+ A + E+ K L++++++ L L+ E+ + A L K QR+ ++
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVED-------LMLDVERTNAACA----ALDKKQRNFDKIL 1459
Query: 1162 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAE 1217
+WK K +E+H ++ Q S EL ++++ ++ +E L+RE ++L+ E+
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 1218 MERSTYVTEVRELKDL-------LTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR 1270
+ + + EL+ + ELQ L++ +EA ++EE +L+ QL K
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEE--AEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1271 TEQNERQK 1278
++ +K
Sbjct: 1578 VDRKIAEK 1585
Score = 103 bits (256), Expect = 1e-21
Identities = 152/681 (22%), Positives = 298/681 (43%), Gaps = 77/681 (11%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 KVANK----EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT 878
KV + E V++L +E+ L E I + EK ++ Q+ + L+ +E+++NT
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNT 1025
Query: 879 M---KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ---EVAQHNLKEASSASQFEELE 932
+ K LE++ DL + + + L+ + E K ++ ++AQ ++ + + Q +L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ--QLD 1083
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
LK+KE E+ L++ +++ ++ L +Q + K +++IE+L+++ + +S
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 993 PHEEL-------LKVISEREKEISGLWN-ELDSLKDAVEHQRKKNNDLREKNWEAMEALA 1044
E+ L+ ISER +E G + +++ K +K DL E + A
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 1045 STEKMLQDKVNKTSKE---RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1101
+ K D V + ++ Q+ + +E E E+ ++ S +S K
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS----------K 1246
Query: 1102 AKECMAGTSGSEEVKVLEHKLKEADEMHTL---------LQLECEKYKSVLAETEGILQK 1152
AK + + E ++ E K KE ++ + LQ E ++ L E E ++ +
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306
Query: 1153 LQRSVE---QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1209
L R + Q+ + K +++E K + + SS + + LR + ++ + + E L
Sbjct: 1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE---L 1363
Query: 1210 EMELEKAEME----RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
+ L KA E R+ Y T+ + + L E +KKL A E +N A L +T
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS 1325
+L+ E + + A +L+ Q K + + + E E+S+KE S
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ-KCEETHAELEASQKEARS 1482
Query: 1326 VSLNQTVTQLQQLLQAVNQQL 1346
+ T+L ++ A + L
Sbjct: 1483 LG-----TELFKIKNAYEESL 1498
Score = 91.7 bits (226), Expect = 4e-18
Identities = 116/571 (20%), Positives = 248/571 (43%), Gaps = 70/571 (12%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
LLK A EK + +K+E + +K+E+ + +K +EL+ + ++ N ++
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSE----------AKRKELEEKMVTLLKEKNDLQ 894
Query: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940
++ + + LA+ + L + L+A ++EV + E ++ + L+++ +
Sbjct: 895 LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 941 ELKR----LEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN--YQQASSFPPH 994
ELK+ LE L + E + + ++++ +E I +L ++ Q+A H
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA-----H 1009
Query: 995 EELLKVISEREKEISGLW-------NELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1047
++ L + E +++ L ++D L+ ++E ++K DL A L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE----RAKRKLEGDL 1065
Query: 1048 KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
K+ Q+ + E+QQ E ++ + E+ L K+ L +KK KE A
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEI-SNLQSKIEDEQALGI-----QLQKKIKELQA 1119
Query: 1108 GTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWK 1165
EE++ +A++ + L E E+ L E G +++ + ++E K
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 1166 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME---RST 1222
++ D T++ ++ T ++ + + + I+NL+R ++ LE E + +ME ++
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQ-------NE 1275
V V + K L ++ + L+D SE + EE L L +L+TE +E
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 1276 RQKVAGDLHKAQQSL------------ELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
++ + L + +Q+ E I++K A + + D+ E E+E+
Sbjct: 1300 KEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES 1359
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
+ +LQ+ L N ++ + + Y+
Sbjct: 1360 KA--------ELQRALSKANTEVAQWRTKYE 1382
Score = 34.3 bits (77), Expect = 0.83
Identities = 42/227 (18%), Positives = 90/227 (39%), Gaps = 17/227 (7%)
Query: 1131 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1190
L E EK + + E QK++ + + E K K ++ +K+ + E E
Sbjct: 846 LKSAETEKEMATMKEE---FQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 1191 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250
L + + L + + LE ++++ ER+ + E+ LT ++KL+D SE
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVT-ERAE---DEEEINAELTAKKRKLEDECSE--- 955
Query: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310
LK +++ L + E+ + + + + I K + ++ +
Sbjct: 956 -------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 1311 DVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 175 bits (444), Expect = 2e-43
Identities = 231/1132 (20%), Positives = 495/1132 (43%), Gaps = 172/1132 (15%)
Query: 308 LKEKSGVIQDALKKSS------KGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ- 360
+KE+ I+D L KS + ++ TL+ + + + A E A ++RC QL +
Sbjct: 858 MKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKT 917
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E ++E N +T +++D L+K+ + + + +E
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A T + L++++ ++N L + +L +
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQ 1036
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ + E +Q L K
Sbjct: 1037 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSD 1144
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----D 628
+ + E + ++++ +AQ + E E K+ + ++ Q E + A+ R D
Sbjct: 1145 LSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHAD 1204
Query: 629 RLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ 688
+ E++ ++Q + L+ E +++ ++ A+ + K + ++ + R LE+Q
Sbjct: 1205 SVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNL---EKMCRTLEDQ 1261
Query: 689 LQHEISNKMEEFKILND---QNKALKSE-------VQKLQTLVSE--QPNKDVVEQMEKC 736
L S + E+ +++ND Q L++E + + + LVS+ + + +Q+E+
Sbjct: 1262 LSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEEL 1321
Query: 737 IQEKDEKLKTVEELL--------ETGLIQVATKEEELNAIRTEN--SSLTKEVQDLKAK- 785
++ +E++K L + L++ +EE+ + + S EV + K
Sbjct: 1322 KRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKY 1381
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
+ D + +EE KK + + ++++ EE +EA K A+ EKT Q L+ E++ L +
Sbjct: 1382 ETDAIQRTEELEEAKKKLAQ---RLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDL---M 1435
Query: 846 GNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTG----------- 894
+V+ A ++ K + +L +++ A LE +K+ + G
Sbjct: 1436 LDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYE 1495
Query: 895 ---KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
L+ L+ EN++L+ QE++ + A + ELE + K+ E E L+A L+E
Sbjct: 1496 ESLDQLETLKRENKNLQ---QEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEE 1552
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGL 1011
E+ L + + +Q E KS++++ + ++ + ++++ + +
Sbjct: 1553 AEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--IRIVESMQSTLDA- 1609
Query: 1012 WNELDSLKDAVEHQRKKNNDLRE----------------KNWEAMEALASTEKMLQDKVN 1055
E+ S DA+ ++K DL E +N+ + + ++ D
Sbjct: 1610 --EIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDAL 1667
Query: 1056 KTSKERQQQVEAVELEAK------EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT 1109
++ ++ ++Q+ VE A E L+ + ++ E L E+ T
Sbjct: 1668 RSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNT 1727
Query: 1110 SGSEEVKVLEHKLKEAD-EMHTLLQLEC---EKYKSVLA-------------ETEGILQK 1152
S K LE + + EM +LQ EK K + +T L++
Sbjct: 1728 SLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787
Query: 1153 LQRSVEQEENKWKVKVDESH--------KTIKQMQSSFTSSEQELERLRSENKD-IENLR 1203
+++++EQ ++++DE+ K I+++++ E E+E + N + ++ LR
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLR 1847
Query: 1204 REREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLN 1263
+ ++ + E +R + L+DL+ +LQ K+ SY + EE Q N
Sbjct: 1848 KHERRVKELTYQTEEDRK----NILRLQDLVDKLQAKV-KSYKRQAEEAEE------QSN 1896
Query: 1264 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPE 1315
L K R Q+E L +A++ ++ +S++ K + + +S E
Sbjct: 1897 TNLAKFRKLQHE-------LEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
Score = 132 bits (332), Expect = 2e-30
Identities = 175/788 (22%), Positives = 350/788 (44%), Gaps = 106/788 (13%)
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQ---------FHSQIAAQTSASV 600
L++ E+E++ +E Q +++D L ++EA + ++++ Q+ Q A
Sbjct: 845 LLKSAETEKEMATMKEEFQ-KIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEG 903
Query: 601 LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
LA+ E+ Q+ +T+ L ++ +T + E D + +N L A+ +KL+ +E
Sbjct: 904 LAD-----AEERCDQLIKTKIQLEAKIKEVTERAE---DEEEINAELTAKKRKLEDECSE 955
Query: 661 QAAAAHELE----KMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQNKA---- 709
+LE K+++ + ++K++ L E+ L I+ +E K L + ++
Sbjct: 956 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1015
Query: 710 LKSEVQKLQTLVS-----EQPNKDV---VEQMEKCIQEKDEKLKTVEELLETGLIQVATK 761
L++E K+ TL EQ D+ +EQ +K + + + +E L+ +
Sbjct: 1016 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDI 1075
Query: 762 EEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAEL 821
E E + + E+ +L++K D+ +L +L+K I E +I+ +EE +EAE
Sbjct: 1076 ENEKQQLDEKLKKKEFEISNLQSKIEDE---QALGIQLQKKIKELQARIEELEEEIEAER 1132
Query: 822 LKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEE---QMN 877
A EK DL +E++ + E + + Q+ + K + E Q + + EE Q
Sbjct: 1133 ASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHE 1192
Query: 878 TMKAVLEEKEKD--------LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE 929
A L +K D + N + Q L++E +K + ++A + + + E
Sbjct: 1193 ATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLE 1252
Query: 930 ELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQ-------DENKLFKSQIEQLKQ 982
++ L+++ +ELK E + +DL+++ LQ DE + SQ+ + KQ
Sbjct: 1253 KMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQ 1312
Query: 983 QNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEA 1042
QQ EEL + + E K + L + L S + + R++ + +E E A
Sbjct: 1313 AFTQQI------EELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRA 1366
Query: 1043 LASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKA 1102
L+ + K + Q+ E +E EAK+ L + L E+
Sbjct: 1367 LSKANTEVAQWRTKYETDAIQRTEELE-EAKKKL---------------AQRLQAAEEHV 1410
Query: 1103 KECMAGTSGSEEVKV-LEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEE 1161
+ A + E+ K L++++++ L L+ E+ + A L K QR+ ++
Sbjct: 1411 EAVNAKCASLEKTKQRLQNEVED-------LMLDVERTNAACA----ALDKKQRNFDKIL 1459
Query: 1162 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRREREHLEMELEKAE 1217
+WK K +E+H ++ Q S EL ++++ ++ +E L+RE ++L+ E+
Sbjct: 1460 AEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1519
Query: 1218 MERSTYVTEVRELKDL-------LTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR 1270
+ + + EL+ + ELQ L++ +EA ++EE +L+ QL K
Sbjct: 1520 EQIAEGGKRIHELEKIKKQVEQEKCELQAALEE--AEASLEHEEGKILRIQLELNQVKSE 1577
Query: 1271 TEQNERQK 1278
++ +K
Sbjct: 1578 VDRKIAEK 1585
Score = 103 bits (256), Expect = 1e-21
Identities = 152/681 (22%), Positives = 298/681 (43%), Gaps = 77/681 (11%)
Query: 712 SEVQKLQTLVSE--QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
+E +K + E Q KD + + E +E +EK+ T+ + +QV + E L
Sbjct: 849 AETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAE 908
Query: 770 TENSSLTKEVQDLKAKQNDQVSFASLVEEL-------KKVIHEKDGKIKSVEELLEAELL 822
L K L+AK + A EE+ K+ + ++ ++K + LE L
Sbjct: 909 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLA 968
Query: 823 KVANK----EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNT 878
KV + E V++L +E+ L E I + EK ++ Q+ + L+ +E+++NT
Sbjct: 969 KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK---ALQEAHQQTLDDLQAEEDKVNT 1025
Query: 879 M---KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ---EVAQHNLKEASSASQFEELE 932
+ K LE++ DL + + + L+ + E K ++ ++AQ ++ + + Q +L+
Sbjct: 1026 LTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQ--QLD 1083
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFP 992
LK+KE E+ L++ +++ ++ L +Q + K +++IE+L+++ + +S
Sbjct: 1084 EKLKKKEFEISNLQSKIEDEQA-------LGIQLQKKIKELQARIEELEEEIEAERASRA 1136
Query: 993 PHEEL-------LKVISEREKEISGLWN-ELDSLKDAVEHQRKKNNDLREKNWEAMEALA 1044
E+ L+ ISER +E G + +++ K +K DL E + A
Sbjct: 1137 KAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA 1196
Query: 1045 STEKMLQDKVNKTSKE---RQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKK 1101
+ K D V + ++ Q+ + +E E E+ ++ S +S K
Sbjct: 1197 TLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVS----------K 1246
Query: 1102 AKECMAGTSGSEEVKVLEHKLKEADEMHTL---------LQLECEKYKSVLAETEGILQK 1152
AK + + E ++ E K KE ++ + LQ E ++ L E E ++ +
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQ 1306
Query: 1153 LQRSVE---QEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHL 1209
L R + Q+ + K +++E K + + SS + + LR + ++ + + E L
Sbjct: 1307 LSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAE---L 1363
Query: 1210 EMELEKAEME----RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
+ L KA E R+ Y T+ + + L E +KKL A E +N A L +T
Sbjct: 1364 QRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKT 1423
Query: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMS 1325
+L+ E + + A +L+ Q K + + + E E+S+KE S
Sbjct: 1424 KQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQ-KCEETHAELEASQKEARS 1482
Query: 1326 VSLNQTVTQLQQLLQAVNQQL 1346
+ T+L ++ A + L
Sbjct: 1483 LG-----TELFKIKNAYEESL 1498
Score = 91.7 bits (226), Expect = 4e-18
Identities = 116/571 (20%), Positives = 248/571 (43%), Gaps = 70/571 (12%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
LLK A EK + +K+E + +K+E+ + +K +EL+ + ++ N ++
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSE----------AKRKELEEKMVTLLKEKNDLQ 894
Query: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKEN 940
++ + + LA+ + L + L+A ++EV + E ++ + L+++ +
Sbjct: 895 LQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECS 954
Query: 941 ELKR----LEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQN--YQQASSFPPH 994
ELK+ LE L + E + + ++++ +E I +L ++ Q+A H
Sbjct: 955 ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA-----H 1009
Query: 995 EELLKVISEREKEISGLW-------NELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1047
++ L + E +++ L ++D L+ ++E ++K DL A L
Sbjct: 1010 QQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE----RAKRKLEGDL 1065
Query: 1048 KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
K+ Q+ + E+QQ E ++ + E+ L K+ L +KK KE A
Sbjct: 1066 KLAQESIMDIENEKQQLDEKLKKKEFEI-SNLQSKIEDEQALGI-----QLQKKIKELQA 1119
Query: 1108 GTSG-SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQ-KLQRSVEQEENKWK 1165
EE++ +A++ + L E E+ L E G +++ + ++E K
Sbjct: 1120 RIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQK 1179
Query: 1166 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME---RST 1222
++ D T++ ++ T ++ + + + I+NL+R ++ LE E + +ME ++
Sbjct: 1180 MRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLAS 1239
Query: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQ-------NE 1275
V V + K L ++ + L+D SE + EE L L +L+TE +E
Sbjct: 1240 NVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDE 1299
Query: 1276 RQKVAGDLHKAQQSL------------ELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
++ + L + +Q+ E I++K A + + D+ E E+E+
Sbjct: 1300 KEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQES 1359
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
+ +LQ+ L N ++ + + Y+
Sbjct: 1360 KA--------ELQRALSKANTEVAQWRTKYE 1382
Score = 34.3 bits (77), Expect = 0.83
Identities = 42/227 (18%), Positives = 90/227 (39%), Gaps = 17/227 (7%)
Query: 1131 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1190
L E EK + + E QK++ + + E K K ++ +K+ + E E
Sbjct: 846 LKSAETEKEMATMKEE---FQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAE 902
Query: 1191 RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250
L + + L + + LE ++++ ER+ + E+ LT ++KL+D SE
Sbjct: 903 GLADAEERCDQLIKTKIQLEAKIKEVT-ERAE---DEEEINAELTAKKRKLEDECSE--- 955
Query: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310
LK +++ L + E+ + + + + I K + ++ +
Sbjct: 956 -------LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEA 1008
Query: 1311 DVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1009 HQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLE 1055
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 174 bits (442), Expect = 4e-43
Identities = 226/1110 (20%), Positives = 480/1110 (43%), Gaps = 152/1110 (13%)
Query: 317 DALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ-------------EMM 363
+A +K + ++ TL+ + + + A + A ++RC QL + E
Sbjct: 871 EAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERA 930
Query: 364 TEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQM---E 416
++E N +T +++D L+K+ + + + +E + K + + E+M +
Sbjct: 931 EDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 990
Query: 417 AEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
IA L +E L++A T + L++++ ++N L + +L ++ + G L+QE+
Sbjct: 991 ETIAKLTKEKKALQEAHQQTLDDLQAEED-KVNTLTKAKIKLEQQVDDLEGSLEQEK--- 1046
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKL 536
++++ L+ A+R+ E ++ T + E +Q L K KE E+ L SK+
Sbjct: 1047 --------KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKI 1098
Query: 537 TDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF 588
D QL++++ +L E E +R ++ ++ + Q D+ + E + ++++
Sbjct: 1099 EDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSDLSRELEEISERLEEA 1157
Query: 589 HSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DRLTSKEEELKDIQNM 643
+AQ + E E K+ + ++ Q E + A+ R D + E++ ++Q +
Sbjct: 1158 GGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRV 1217
Query: 644 NFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNK 696
L K E+ L + + A LEKM +++ + +I+ EE+ Q I++
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDL 1277
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ L ++ ++ + TLVS+ Q +E++++ ++E+ + + L
Sbjct: 1278 TAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHAL 1337
Query: 752 ETG------LIQVATKEEELNA-IRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVI 803
++ L + +E+E A ++ S EV + K + D + +EE KK +
Sbjct: 1338 QSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Query: 804 HEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQ-----LEKAQQ--- 855
+ +++ EE +EA K A+ EKT Q L+ E++ L ++ L+K Q+
Sbjct: 1398 AQ---RLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFD 1454
Query: 856 ---LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ 912
K +E L+ +++ ++ L + + + L+ L+ EN++L+ Q
Sbjct: 1455 KILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQ---Q 1511
Query: 913 EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKL 972
E++ + A + ELE + K+ E E L+A L+E E+ L + + +Q E
Sbjct: 1512 EISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQ 1571
Query: 973 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1032
KS++++ + ++ + ++++ + + E+ S DA+ ++K DL
Sbjct: 1572 VKSEVDRKIAEKDEEIDQMKRNH--IRIVESMQSTLDA---EIRSRNDAIRLKKKMEGDL 1626
Query: 1033 RE----------------KNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK--- 1073
E +N+ +A+ ++ D ++ ++ ++Q+ VE A
Sbjct: 1627 NEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQ 1686
Query: 1074 ---EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD-EMH 1129
E L+ + ++ E L E+ TS K LE + + EM
Sbjct: 1687 AEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746
Query: 1130 TLLQLEC---EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1186
++Q EK K + + + ++L++ + + ++K +T+K +Q +E
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK-KNLEQTVKDLQHRLDEAE 1805
Query: 1187 QELERLRSENKDIENLRREREHLEMELE----------------KAEMERSTYVTE---- 1226
Q L+ K I+ L LE E+E + +++ TY TE
Sbjct: 1806 Q--LALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRK 1863
Query: 1227 -VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
+ L+DL+ +LQ K+ SY + EE Q N L+K R Q+E L +
Sbjct: 1864 NILRLQDLVDKLQAKV-KSYKRQAEEAEE------QSNVNLSKFRRIQHE-------LEE 1909
Query: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPE 1315
A++ ++ +S++ K + + +S E
Sbjct: 1910 AEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 137 bits (346), Expect = 5e-32
Identities = 205/980 (20%), Positives = 396/980 (40%), Gaps = 131/980 (13%)
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
+++ +++ ++ Q V+ + W ++ Y + + A + + + +
Sbjct: 802 RVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSA---ETEKEMANMKE 858
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ---DILEQNEALKAQ 584
E + +L T +++LE++++ LM+ ++ LQ+QVQ D L E Q
Sbjct: 859 EFEKTKEELAKTEAKRKELEEKMVTLMQ-------EKNDLQLQVQAEADSLADAEERCDQ 911
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL-KDIQNM 643
+ + Q+ A+ K + E+ + ++ L +++ +L + EL KDI ++
Sbjct: 912 LIKTKIQLEAKI----------KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDL 961
Query: 644 NFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKIL 703
L ++ A N+ E+ + +++ + + L+E Q + + E +
Sbjct: 962 ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKV 1021
Query: 704 NDQNKA-LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKE 762
N KA +K E Q S + K + +E+ ++ + LK +E +
Sbjct: 1022 NTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLD 1081
Query: 763 EELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELL 822
E+L E S L +++D +A L +L+K I E +I+ +EE +EAE
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQA----------LGMQLQKKIKELQARIEELEEEIEAERA 1131
Query: 823 KVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEE---QMNT 878
A EK DL +E++ + E + + Q+ + K + E Q + + EE Q
Sbjct: 1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191
Query: 879 MKAVLEEKEKD--------LANTGKWLQDLQEENESLKAHVQEVAQH---------NLKE 921
A L +K D + N + Q L++E +K + ++A + NL++
Sbjct: 1192 TAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEK 1251
Query: 922 ASSASQFEELEIVLKEKE-----NEL----KRLEAMLKERESDLSSKTQLLQDVQDENKL 972
A + + EI KE+E N+L RL+ E L K L+ + +
Sbjct: 1252 MCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA 1311
Query: 973 FKSQIEQLKQQNYQQ--ASSFPPHE--------ELLKVISEREKEISG-LWNELDSLKDA 1021
F QIE+LK+Q ++ A S H +LL+ E E+E L +
Sbjct: 1312 FTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSE 1371
Query: 1022 VEHQRKK-NNDLREKNWEAMEALASTEKMLQD-------------KVNKTSKERQQQVE- 1066
V R K D ++ E EA + LQD + KT + Q +VE
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVED 1431
Query: 1067 -AVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA 1125
+++E K + EW E+ E A S + K+K A
Sbjct: 1432 LMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNA 1491
Query: 1126 -----DEMHTLLQLECEKYKSVLAETEGI---------LQKLQRSVEQEENKWKVKVDES 1171
D++ TL + + + TE I L+K+++ VEQE+++ + ++E+
Sbjct: 1492 YEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEA 1551
Query: 1172 HKTIKQMQSSFTSSEQELERLRSE------NKDIENLRREREHLEMELEKAEMERSTYVT 1225
+++ + + EL +++SE KD E + +R H+ + E +ST
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI----VESMQSTLDA 1607
Query: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQ-----------LNETLTKLRTEQN 1274
E+R D + L+KK++ +E Q N + A+ L +T L
Sbjct: 1608 EIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALR 1666
Query: 1275 ERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE---SSEKETMSVSLNQT 1331
++ + L ++ L+Q++I + E S E E +SE+ + + N +
Sbjct: 1667 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1726
Query: 1332 VTQLQQLLQAVNQQLTKEKE 1351
+ ++ L+ Q+ E E
Sbjct: 1727 LINTKKKLETDISQIQGEME 1746
Score = 36.6 bits (83), Expect = 0.17
Identities = 38/220 (17%), Positives = 88/220 (40%), Gaps = 38/220 (17%)
Query: 1166 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN----LRREREHLEMELE------- 1214
+K E+ K + M+ F +++EL + ++ K++E L +E+ L+++++
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLA 903
Query: 1215 ----------KAEMERSTYVTEV-------RELKDLLTELQKKLDDSYSEAVRQNEELNL 1257
K +++ + EV E+ LT ++KL+D SE
Sbjct: 904 DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE---------- 953
Query: 1258 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETE 1317
LK +++ L + E+ + + + + I K + ++ + +
Sbjct: 954 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 1318 SSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+E +L + +L+Q + + L +EK+ LE
Sbjct: 1014 LQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLE 1053
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 174 bits (441), Expect = 5e-43
Identities = 264/1338 (19%), Positives = 576/1338 (43%), Gaps = 161/1338 (12%)
Query: 90 LAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT 149
LA++ D V + V + +S++E K ++ K LE+ + +K G +
Sbjct: 78 LALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDS---- 133
Query: 150 KQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKK 209
+E + +++ + +++N + Q K + E + + +E +
Sbjct: 134 -----SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREA 188
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLK-PDQVEGIQKSGT 268
+ TE + + +I L V K+E++ + D + ++ +
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 269 KKLKTETDKENAEVKFKDFLLS-LKTMMFS--EDEALCVVDLLKEKSGVIQDALKKSSKG 325
+KLK E K ++ + +S L++ + ++ A+ V +L K KS V + K +
Sbjct: 249 EKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLT 308
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
E L+ + Q+ KL E++ + K+ L Q+ ++ +++ R+ E
Sbjct: 309 E--NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQK--------DLDCQQLQSRLSASET 358
Query: 386 EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDA----------VSN 435
++IHV E + K ++ ++E + HLK E L+ + +
Sbjct: 359 S----LHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414
Query: 436 TTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAER 495
NQL SK +L + + RL + + KL +E Q + + ++L+ QL+E
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVT 474
Query: 496 RWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLME 555
E+Q + K +H+ QQ LQ AK E Q+ ++ + K Q Q L L++
Sbjct: 475 NSTELQHQLDKTKQQHQE-QQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQ 533
Query: 556 SEQKRVN----KEESLQMQVQ----------DILEQNEALKAQIQQFHSQIAAQTSASVL 601
++ ++ + E L ++Q + E+N L+ Q+ Q ++ Q+ +
Sbjct: 534 KSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQ 593
Query: 602 AEE-LHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKD-IQNMNFLLKAEVQKL-- 654
A+E LH + E+ ++ +D SL + + L S+ E K+ + ++ +KA+ + L
Sbjct: 594 AQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLS 653
Query: 655 --QALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-------------EISNKMEE 699
A ++A + L+ Q ++ K ++ + QL ++ + ++E
Sbjct: 654 AEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKE 713
Query: 700 FK----ILNDQNKALKSEVQKLQT------LVSEQPNKDVVEQ------MEKCIQEKDEK 743
+K L + + L+ +++KL+ EQ +D+ +Q +E E ++
Sbjct: 714 YKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQ 773
Query: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----------QNDQVS-- 791
L+ +E++ + + + K E L +I+ + + +E Q LK Q+++++
Sbjct: 774 LEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNR 833
Query: 792 FASLVEELKKVIHEKDG----------KIKSVEELLE---AELLKVANKEKT-VQDLKQE 837
+ V EL+KV EK+ K+ V + L+ +E K K K + DL++
Sbjct: 834 IQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT 893
Query: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
K LK ++ VQ+E + + +EL+ L+ ++E + +K L ++ L L
Sbjct: 894 CKELKHQL-QVQMENTLK-----EQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 898 QDLQEENESLKAHVQEVAQHNLKEASSASQFE-ELEIVLKEKENELKRLEAMLKERESDL 956
+ ++E + L+ ++ E+ Q + ++ + EL+I + +K +L+ L + +L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 957 SSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD 1016
+++ + + +Q+ + + +QL+ Y + S + LK + E+ +S +L
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEK---LSLAQEDLI 1064
Query: 1017 SLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVL 1076
S ++ + +Q K +L+ + A E+ LQ++ K Q + L+ KE+
Sbjct: 1065 SNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERC----KALQDIQKEKSLKEKEL- 1119
Query: 1077 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLEC 1136
V+ S L+ E E K ++ T +EE+K HKL+ E+ L +
Sbjct: 1120 ------VNEKSKLAEIE-----EIKCRQEKEITKLNEELK--SHKLESIKEITNLKDAKQ 1166
Query: 1137 EKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
+ L E +G L+ +VEQE+ ++ D+ K ++++ F E +L SE
Sbjct: 1167 LLIQQKL-ELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEA---KLHSEI 1222
Query: 1197 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELN 1256
K+ E+ ++K E + ++ L + L ++K+ S ++ +
Sbjct: 1223 KE----------KEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTD 1272
Query: 1257 LLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1316
L+ ++ ++ Q+ER+ + K + +E +Q+K+++ ++N+ + +
Sbjct: 1273 DLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLEL---QRKLDNTTAAVQE 1329
Query: 1317 ESSEKETMSVSLNQTVTQ 1334
E +++ + Q + +
Sbjct: 1330 LGRENQSLQIKHTQALNR 1347
Score = 145 bits (365), Expect = 3e-34
Identities = 225/1018 (22%), Positives = 427/1018 (41%), Gaps = 171/1018 (16%)
Query: 430 RDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ 489
RD V+ +++ Q++ K + Y+ + + EK LQQ+E + + T +
Sbjct: 82 RDDVTLLRQEVQDLQASL--KEEKWYSEELKKELEKYQGLQQQEAKP---DGLVTDSSAE 136
Query: 490 LQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQR 549
LQ E++ EE Q+ + + + K E+ + SK + ++ EQ+
Sbjct: 137 LQSLEQQLEEAQT----ENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQK 192
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
+ +L E +NKE ++ ++ L Q ++ +VL +EL
Sbjct: 193 VTRLTEE----LNKEATVIQDLKTELLQRPGIE--------------DVAVLKKEL---- 230
Query: 610 AEKDKQIKQTEDSLASERDRLTSK-EEELKDIQNMNFLLKAEVQKLQA-LAN---EQAAA 664
Q++ D++ ER+R + K ++E K +Q+ +A + +L++ LA E A
Sbjct: 231 ----VQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVY 286
Query: 665 AHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQ 724
EL+K++ SV K + L E L L + K E + + VS++
Sbjct: 287 VQELQKLKSSVNELTQKNQTLTENL-------------LKKEQDYTKLEEKHNEESVSKK 333
Query: 725 PNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKA 784
+ + Q + Q+ +L E L ++++ K E ++ E S + + Q LKA
Sbjct: 334 NIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 785 KQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEE 844
+ ++L++ EK+ ++ + K+ E+ + + +K ++
Sbjct: 394 E----------FKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQL 443
Query: 845 IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN 904
++K QQ V +LQ L EEQ+ E + L T + Q+ Q
Sbjct: 444 SSEKLMDKEQQ------VADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQ 497
Query: 905 ESLKAHVQEVAQHNLKEA-----SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 959
+S A ++E AQ++L++ + + LE +L++ + + LE KERE DL +K
Sbjct: 498 QSTTAKLRE-AQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLE---KERE-DLYAK 552
Query: 960 TQ-------LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLK-VISEREKEISGL 1011
Q +L +Q++N + Q+ QL ++ Q+ S +E L + E++ +
Sbjct: 553 IQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAA 612
Query: 1012 WNELDSLKDAVEHQRKKNNDLREKNWEA-MEALASTEKMLQDKVNKTSK----------- 1059
+ + SL+ +V + N+ +EK + ++ A TE +L + KT++
Sbjct: 613 QDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTA 672
Query: 1060 -----ERQQQVEAVELEAKEVLKKLFPKVSVPSNLS-----YGEWLHGFEKKAKECMAGT 1109
++QQ++ + + +V KL K S L Y E E+K +E + G
Sbjct: 673 QNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEE-LEGQ 731
Query: 1110 SGSEEVKVLEHK---------LKEADEMHTLLQL-------ECEKYKSVLAETEGILQKL 1153
E LE K L++ +++T L+L + E K +++ T LQK
Sbjct: 732 IKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK 791
Query: 1154 QRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENK-DIENLRREREHLEME 1212
++E + K K +E + +KQ + E L E K E L + E
Sbjct: 792 SEALESIKQKL-TKQEEEKQILKQ----------DFETLSQETKIQHEELNNRIQTTVTE 840
Query: 1213 LEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEE-----LNL---------- 1257
L+K +ME+ +TE+ +KD L+++ L +S SE ++N++ L+L
Sbjct: 841 LQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQ 900
Query: 1258 LKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSD------ 1311
L+ Q+ TL + + + +K H+ + L +Q ++++A E +
Sbjct: 901 LQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGN 960
Query: 1312 -----VSPETESSEKETMSVSLNQTVTQ-------LQQLLQAVNQQLTKEKEHYQVLE 1357
S E + + E + L V Q LQQ L Q+L EKE VL+
Sbjct: 961 INELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Score = 122 bits (307), Expect = 2e-27
Identities = 184/987 (18%), Positives = 419/987 (42%), Gaps = 134/987 (13%)
Query: 46 KLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVV 105
KL+ T+ +A + +++++ + L + + + KLS ++Q+ N
Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRL----EEQLKEKVTNST 477
Query: 106 ETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKP 165
E + + K++ ++Q+ + + K +A + + + Q EA K K
Sbjct: 478 ELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKE 537
Query: 166 GQKKSKNGSDDQDKKV-----ETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTEN 220
+ +D K+ ET ++ +++ L ++ Q + K ++ S KQ EN
Sbjct: 538 NISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQEN 597
Query: 221 VF--VDEPLIH---ATTYIPLMD------NADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
+ V E H A + ++ N+ + +K +D+ + E + +
Sbjct: 598 LHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAA 657
Query: 270 KLKTETDKEN----AEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG 325
K D +N A+ +D L + D+ + +E ++ LK+ K
Sbjct: 658 KTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEY-KE 716
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEK 385
+ +L + +E + + ++ D+ K +Q Q++ +++ + + R + LE
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
Query: 386 EHNVFQN------KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQ 439
E + + K + + +Q K ++ ++ ++ + L QE I + ++N
Sbjct: 777 EKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQT 836
Query: 440 LESKQSAELNKLRQDYARLVNELTEKTGKLQQ---------EEVQKKNA---------EQ 481
+ EL K++ + L+ EL+ KL + E +K+N E+
Sbjct: 837 TVT----ELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEK 892
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
+LK QLQ + Q ++K + + A L+ + + + ++ + L
Sbjct: 893 TCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 542 SKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL 601
+QQL+ + +L +S +++ + E+LQ +++ + Q L+ ++QQ
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQ-------------- 998
Query: 602 AEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQ 661
Q+ Q LA+E+++++ + + Q + + L ++
Sbjct: 999 -------------QLTQAAQELAAEKEKISVLQNNYEKSQ----------ETFKQLQSDF 1035
Query: 662 AAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLV 721
EL +Q + ++K+ L +E L ISN+ + + +QNK ++ E++ + +
Sbjct: 1036 YGRESELLATRQDLKSVEEKLSLAQEDL---ISNRNQ----IGNQNKLIQ-ELKTAKATL 1087
Query: 722 SEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR-TENSSLTKEVQ 780
+ K + E+C +D ++ + L E L+ +K E+ I+ + +TK +
Sbjct: 1088 EQDSAKKEQQLQERCKALQD--IQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNE 1145
Query: 781 DLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLE----AELLKVA--NKEKTVQDL 834
+LK+ + +E +K++ + KD K +++ LE A+ LK A +++ Q L
Sbjct: 1146 ELKSHK---------LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQIL 1196
Query: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEE-------QMNTMKAVLEEKE 887
K ++K +EE+ +EK +L S+++E + +K EE Q+ + L +
Sbjct: 1197 KDQVKKEEEELKKEFIEKEAKLH--SEIKEKEVGMKKHEENEAKLTMQITALNENLGTVK 1254
Query: 888 KDLANTGKWLQDLQEENESLKAHV---QEVAQHNLKEASSASQFEELEIVLKEKENELKR 944
K+ ++ + + +L+++ + L+ + + Q+N E + LE LK E E+++
Sbjct: 1255 KEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRAL-----LERCLK-GEGEIEK 1308
Query: 945 LEAMLKERESDLSSKTQLLQDVQDENK 971
L+ + E + L + T +Q++ EN+
Sbjct: 1309 LQTKVLELQRKLDNTTAAVQELGRENQ 1335
Score = 92.4 bits (228), Expect = 3e-18
Identities = 159/814 (19%), Positives = 322/814 (39%), Gaps = 172/814 (21%)
Query: 703 LNDQNKALKSEVQKLQTL-VSEQPNKD--VVEQMEKCIQEKDEKLKTVEELLETGLIQVA 759
+ Q L S + T+ V+ + + + + Q K + DE K E + + G
Sbjct: 13 VGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGH 72
Query: 760 TKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDG----------- 808
E L R + + L +EVQDL+A ++ ++ EELKK + + G
Sbjct: 73 GGESNLALKRDDVTLLRQEVQDLQASLKEEKWYS---EELKKELEKYQGLQQQEAKPDGL 129
Query: 809 -----------------------KIKSVEELLEAELLKVA-------------------- 825
IK +++L E + ++A
Sbjct: 130 VTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAA 189
Query: 826 -----------NKEKTV-QDLK---------QEIKALKEEIGNVQ-LEKAQQLSITSKVQ 863
NKE TV QDLK +++ LK+E+ VQ L L + +
Sbjct: 190 EQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESE 249
Query: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
+L++ K + Q + +A + + +LA + + +E + LK+ V E+ Q N
Sbjct: 250 KLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTE 309
Query: 924 SASQFEELEIVLKEKENE----LKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
+ + E+ L+EK NE K ++A L +++ D L E L + +E
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS--ASETSLHRIHVEL 367
Query: 980 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1039
++ Q +L + +SE E + L E L+ E + + L+ + +
Sbjct: 368 SEKGEATQ--------KLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL 419
Query: 1040 MEALASTEKMLQDKVNKTSKERQ----------QQVEAVELEAKEVLKKLFPKVSVPSNL 1089
L TE+ L + + ++RQ QQV ++L+ + ++L KV+ + L
Sbjct: 420 HSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTEL 479
Query: 1090 SYGEWLHGFEKKAKECMAGTS------------------GSEEVKV--LEHKLKEADEMH 1129
+ + + ++ + ++ G ++ K+ LE L+++ E
Sbjct: 480 QHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENI 539
Query: 1130 TLLQLECEKYKSVLAETEG---ILQKLQ---RSVEQEENKWKVKVDESHKTIKQMQSSFT 1183
+LL+ E E + + EG +L +LQ +++++ + K+ ++ KQ Q +
Sbjct: 540 SLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLH 599
Query: 1184 SSEQELE-RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLL-------- 1234
QE + LR+ + +L L +L +++ + S +++ +LL
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 1235 ---TELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK------ 1285
+LQ LD + + + +ELN + QL++ KL+ +Q ++ L +
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 1286 -AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQL--------- 1335
+Q E ++ +I K D+ ++ S + ++ ++ L T+L
Sbjct: 720 SLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKE 779
Query: 1336 ------------QQLLQAVNQQLTKEKEHYQVLE 1357
+ L+++ Q+LTK++E Q+L+
Sbjct: 780 IVSSTRLDLQKKSEALESIKQKLTKQEEEKQILK 813
Score = 63.9 bits (154), Expect = 1e-09
Identities = 119/654 (18%), Positives = 250/654 (38%), Gaps = 129/654 (19%)
Query: 51 KTDKKKAEKKKNKKKEIQN-GNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSS 109
K + E K +K++ +Q+ + +++ R +LS L +E + V+ L++ + S
Sbjct: 734 KLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSE 793
Query: 110 ---SVRERKKKEKKQKPVLEEQVIKESDASKIPGKKV----------------------- 143
S++++ K++++K +L++ S +KI +++
Sbjct: 794 ALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMT 853
Query: 144 EPVPVTKQPTPPSEAAASKKKPGQKKSKNGSD---DQDKKVETLMVPSKRQEALPLHQET 200
E V + + S++ + K +K+++ G D +K + L + Q L ++
Sbjct: 854 ELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQK 913
Query: 201 KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSS----------------- 243
+ + K+K +S + K E + E LI A + + +
Sbjct: 914 ELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKK 973
Query: 244 -----------PVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLK 292
V+ K E+ + L+ + Q+ +K K + N E + F
Sbjct: 974 QIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQS 1033
Query: 293 TMMFSEDEALCVVDLLK---EKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAA 349
E E L LK EK + Q+ L S++ ++ +QE A +++D+A
Sbjct: 1034 DFYGRESELLATRQDLKSVEEKLSLAQEDLI-SNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 350 ATK----DRCKQLTQEMMTEKERSNVVITRMKDRIGTLE-----------------KEHN 388
+ +RCK L Q++ EK + K ++ +E K H
Sbjct: 1093 KKEQQLQERCKAL-QDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHK 1151
Query: 389 VFQNKIHVSYQETQQM----QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQ 444
+ K + ++ +Q+ +++ Q + ++A + K+ IL+D V K+
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVK--------KE 1203
Query: 445 SAELNK-LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSY 503
EL K + A+L +E+ EK +++ E + T L L ++ W+ Q
Sbjct: 1204 EEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQ-- 1261
Query: 504 IRKRTAEHEAAQQDLQSKFVAKENEVQS----------------------------LHSK 535
+R +E E DL+ + E VQ+ L K
Sbjct: 1262 --RRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRK 1319
Query: 536 LTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFH 589
L +T + Q+L + L + +N++ + +VQ+ + + +++ H
Sbjct: 1320 LDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHH 1373
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 172 bits (437), Expect = 2e-42
Identities = 246/1205 (20%), Positives = 531/1205 (44%), Gaps = 173/1205 (14%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++R++ + +E +K+ +++++ E V L+ + L
Sbjct: 835 KIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVS--LLQEKNDLQLQVQ 892
Query: 240 ADSSPVVDKREVIDLLKPD--QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+ + D E D L + Q+E K ++L+ E ++ NAE+ K +D LK
Sbjct: 893 AEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELK 951
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+++A + ++ A +
Sbjct: 952 RDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1000
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E V + K+ +
Sbjct: 1001 EAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1060
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
TQ+ M + ++Q++ + E L + + E ++L K ++ +
Sbjct: 1061 LTQESIMDLENDKQQLDERLKKKDFELNALNARIED-----EQALGSQLQKKLKELQARI 1115
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTAEHE 512
EL E+ L+ E + E+ + L +L+E R EE +KR AE +
Sbjct: 1116 EELEEE---LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1172
Query: 513 AAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQ 572
++DL+ + E +L K D++ +L +++ L +QK ++ ++++
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEFKLELD 1229
Query: 573 DI---LEQNEALKAQIQQF----------HSQIAAQTSASV--LAEELHKVIAEKDKQIK 617
D+ +EQ KA +++ H A +T SV L + K+ E + +
Sbjct: 1230 DVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSR 1289
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
Q ++ A K + ++++ L+ EV+ ALA+ +A H+ +
Sbjct: 1290 QLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCD-------- 1341
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI 737
LL EQ + E K E ++L+ N + K +T ++ E++E+
Sbjct: 1342 ------LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-----TEELEEAK 1390
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFA 793
++ ++L+ EE +E + ++ E+ + ++ E L +V+ A Q +F
Sbjct: 1391 KKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1450
Query: 794 SLVEELKKVIHEKDGKIKSVEE---LLEAELLKVANK-EKTVQDL---KQEIKALKEEIG 846
++ E K+ E +++S ++ L EL K+ N E++++ L K+E K L+EEI
Sbjct: 1451 KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS 1510
Query: 847 NVQLEKAQQLSITSK-VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE 905
++ +QL + K + EL+ + K E + +++ LEE E L + + Q E
Sbjct: 1511 DL----TEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFN 1566
Query: 906 SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQD 965
+KA + E A + EE+E + K N L+ ++++ +++ S+ + L+
Sbjct: 1567 QIKAEI---------ERKLAEKDEEME---QAKRNHLRVVDSLQTSLDAETRSRNEALRV 1614
Query: 966 VQD-ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH 1024
+ E L + +I QL N A + + L ++ + + ++ D LK+ +
Sbjct: 1615 KKKMEGDLNEMEI-QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAI 1673
Query: 1025 QRKKNNDLREKNWEAMEALASTE---KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFP 1081
++NN L+ + E + TE K+ + ++ +TS E V+L + +
Sbjct: 1674 VERRNNLLQAELEELRAVVEQTERSRKLAEQELIETS-------ERVQLLHSQNTSLINQ 1726
Query: 1082 KVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS 1141
K + ++LS + + +E + +E + E K K+A ++ E +K +
Sbjct: 1727 KKKMDADLSQ------LQTEVEEAV------QECRNAEEKAKKAITDAAMMAEELKKEQ- 1773
Query: 1142 VLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN 1201
+T L+++++++EQ + ++DE+ Q + +++L++L + +++EN
Sbjct: 1774 ---DTSAHLERMKKNMEQTIKDLQHRLDEAE------QIALKGGKKQLQKLEARVRELEN 1824
Query: 1202 -----LRREREHLE-MELEKAEMERSTYVTE-----VRELKDLLTELQKKLDDSYSEAVR 1250
+R E ++ M + ++ TY TE + L+DL+ +LQ K+ +Y
Sbjct: 1825 ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK-AYKRQAE 1883
Query: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310
+ EE Q N L+K R KV +L +A++ ++ +S++ K + I
Sbjct: 1884 EAEE------QANTNLSKFR-------KVQHELDEAEERADIAESQVNKLRAKSRDIGTK 1930
Query: 1311 DVSPE 1315
++ E
Sbjct: 1931 GLNEE 1935
Score = 136 bits (342), Expect = 2e-31
Identities = 199/937 (21%), Positives = 386/937 (41%), Gaps = 115/937 (12%)
Query: 472 EEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQS 531
EE++ + + T+++ Q + R E + + +R Q ++++ K
Sbjct: 774 EEMRDERLSRIITRIQAQSRGVLARMEYKK--LLERRDSLLVIQWNIRAFMGVKNWPWMK 831
Query: 532 LHSKLTDTLVSKQQ------LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
L+ K+ L S ++ +++ +L E+ +K + + L+ ++ +L++ L+ Q+
Sbjct: 832 LYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQV 891
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD---RLTSKEEEL----- 637
Q +A A ++L K + + ++K+ + L E + LT+K+ +L
Sbjct: 892 QAEQDNLA---DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECS 948
Query: 638 ---KDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEIS 694
+DI ++ L ++ A N+ E+ + + + + + L+E Q +
Sbjct: 949 ELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALD 1008
Query: 695 NKMEEFKILNDQNKA---LKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELL 751
+ E +N KA L+ +V L+ + ++ K V +E+ ++ + LK +E +
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQE--KKVRMDLERAKRKLEGDLKLTQESI 1066
Query: 752 ETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIK 811
+E L E ++L ++D +A L +L+K + E +I+
Sbjct: 1067 MDLENDKQQLDERLKKKDFELNALNARIEDEQA----------LGSQLQKKLKELQARIE 1116
Query: 812 SVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLK 870
+EE LEAE A EK DL +E++ + E + + Q+ + K + E Q + +
Sbjct: 1117 ELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1176
Query: 871 GKEE---QMNTMKAVLEEKEKD-LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSAS 926
EE Q A L +K D +A G+ + +LQ + L+ +E ++ L+ S
Sbjct: 1177 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLE---KEKSEFKLELDDVTS 1233
Query: 927 QFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQ 986
E+ ++K K N LE M + E ++ ++ Q SQ +L+ +N +
Sbjct: 1234 NMEQ---IIKAKAN----LEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGE 1286
Query: 987 QASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALAST 1046
+ E L+ ++ + + +L+ LK +E + K N L
Sbjct: 1287 LSRQLDEKEALISQLTRGKLTYT---QQLEDLKRQLEEEVKAKNALAHA----------- 1332
Query: 1047 EKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
LQ + R+Q E E EAK L+++ K +N +W +E A +
Sbjct: 1333 ---LQSARHDCDLLREQYEE--ETEAKAELQRVLSK----ANSEVAQWRTKYETDA---I 1380
Query: 1107 AGTSGSEEVKV-LEHKLKEADEMHTLLQLEC---EKYKSVLA-ETEGI------------ 1149
T EE K L +L+EA+E + +C EK K L E E +
Sbjct: 1381 QRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440
Query: 1150 -LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKD----IENLRR 1204
L K QR+ ++ +WK K +ES ++ Q S EL +L++ ++ +E +R
Sbjct: 1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500
Query: 1205 EREHLEMELE--------------KAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250
E ++L+ E+ + E R E EL+ L E + L+ + +R
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 1560
Query: 1251 QNEELNLLKAQLNETLTKLRTEQNE-RQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIEN 1309
E N +KA++ L + E + ++ + Q SL+ +A +E
Sbjct: 1561 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 1620
Query: 1310 SDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQL 1346
E + S M+ + V LQ LL+ QL
Sbjct: 1621 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQL 1657
Score = 40.4 bits (93), Expect = 0.012
Identities = 46/221 (20%), Positives = 95/221 (42%), Gaps = 40/221 (18%)
Query: 1166 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIE----NLRREREHLEMELEKAEMERS 1221
+K E K + M+ FT ++ LE+ + K++E +L +E+ L+++++ AE +
Sbjct: 840 LKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQ-AEQDNL 898
Query: 1222 TYVTE---------------VRELKDL----------LTELQKKLDDSYSEAVRQNEELN 1256
E V+E+ + LT ++KL+D SE R ++L
Sbjct: 899 ADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958
Query: 1257 LLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPET 1316
L TL K+ E++ + +L + L+ I +K+ K + ++ +
Sbjct: 959 L-------TLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTK---EKKALQEAHQQALD 1008
Query: 1317 ESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+ +E +L + +L+Q + + L +EK+ LE
Sbjct: 1009 DLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLE 1049
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 171 bits (434), Expect = 3e-42
Identities = 238/1114 (21%), Positives = 481/1114 (43%), Gaps = 168/1114 (15%)
Query: 308 LKEKSGVIQDALKKSS--KGELTT-LIHQLQEKDKLLAAVKEDA---AATKDRCKQLTQ- 360
+KE+ +D L KS + EL ++ L+EK+ L V+ +A A ++RC+QL +
Sbjct: 855 MKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKN 914
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E E+E N +T +++D L+K+ + + + +E
Sbjct: 915 KIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++ T + L++++ ++N L + +L +
Sbjct: 975 ENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEED-KVNILTKAKTKLEQQ 1033
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ +L++ L+ A+R+ E ++ T + E +Q L K
Sbjct: 1034 VDDLEGSLEQEK-----------KLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQD 573
KE E+ +L SK+ D + QL++++ +L E E +R ++ ++ + Q D
Sbjct: 1083 LEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKA-EKQRSD 1141
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSAS--------VLAEELHKVIAEKDKQI----KQTED 621
+ + E + ++++ +AQ + L +L + + + + K+ D
Sbjct: 1142 LSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD 1201
Query: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
S+A +++ + + + ++ LK E L + A + A LEKM +S+ + +
Sbjct: 1202 SMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSE 1261
Query: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKC 736
++ EE+ Q I++ + L + ++ + LVS+ Q + +E+++
Sbjct: 1262 LKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ 1321
Query: 737 IQEKDEKLKTVEELLETG-----LIQVATKEEELNAIRTEN--SSLTKEVQDLKAK-QND 788
++E+ + + L++ L++ +EE+ + S EV + K + D
Sbjct: 1322 LEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD 1381
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN- 847
+ +EE KK + + +++ EE +EA K A+ EKT Q L+ E++ L ++
Sbjct: 1382 AIQRTEELEEAKKKLAQ---RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERS 1438
Query: 848 ----VQLEKAQQ------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWL 897
L+K Q+ K +E Q L+ +++ ++ L + + + L
Sbjct: 1439 NAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL 1498
Query: 898 QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLS 957
+ L+ EN++L+ QE++ + A Q ELE + K+ E E ++A L+E E+ L
Sbjct: 1499 ETLRRENKNLQ---QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLE 1555
Query: 958 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017
+ + +Q E KS++++ + ++ + +V+ + + E+ S
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNH--TRVVETMQSTLDA---EIRS 1610
Query: 1018 LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVE-LEAKEVL 1076
DA+ ++K DL E + A + L++ N ++ Q+ + L +E L
Sbjct: 1611 RNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDL 1670
Query: 1077 KKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEV-KVLEHKLKEADEMHTLLQLE 1135
K+ V +NL + + +E A +E K+ E +L +A E LL +
Sbjct: 1671 KEQLAIVERRANL--------LQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ 1722
Query: 1136 CEKYKSVLAETEGILQKLQRSVEQ--------EENKWKVKVDES---------------- 1171
+ + E + +LQ VE+ EE K D +
Sbjct: 1723 NTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1782
Query: 1172 -------HKTIKQMQSSFTSSE-----------QELE-RLRSENKDIENLRREREHLEME 1212
+T+K +Q +E Q+LE R+R ++EN ++
Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKG 1842
Query: 1213 LEKAE--MERSTYVTE-----VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNET 1265
L K E ++ TY TE V L+DL+ +LQ K+ SY + EE Q N
Sbjct: 1843 LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKV-KSYKRQAEEAEE------QSNAN 1895
Query: 1266 LTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299
L+K R Q+E L +A++ ++ +S++ K
Sbjct: 1896 LSKFRKLQHE-------LEEAEERADIAESQVNK 1922
Score = 130 bits (328), Expect = 7e-30
Identities = 167/835 (20%), Positives = 366/835 (43%), Gaps = 105/835 (12%)
Query: 550 LMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
L++ E+E++ +E Q + +D L ++EA + +++ E++ ++
Sbjct: 842 LLKSAETEKEMATMKEEFQ-KTKDELAKSEAKRKELE----------------EKMVTLL 884
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
EK+ Q + SE D L EE + + L+A+++++ A E+ EL
Sbjct: 885 KEKNDLQLQVQ----SEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELT 940
Query: 670 KMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKI-LNDQNKALKSEVQKLQTLVSEQPNKD 728
K R LE++ E+ +++ ++ L K + K++ L E D
Sbjct: 941 A----------KKRKLEDECS-ELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD 989
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQND 788
E + K +EK K ++E + L + +E+++N + + L ++V DL+
Sbjct: 990 --ETIAKLSKEK----KALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ 1043
Query: 789 QVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN- 847
+ +E K+ + +G +K +E + E Q L ++++ + EI N
Sbjct: 1044 EKKLRMDLERAKRKL---EGDLKLAQE-------STMDMENDKQQLDEKLEKKEFEISNL 1093
Query: 848 ---VQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEEN 904
++ E+A ++ + K++ELQ ++ E++ +A + EK ++ + L+++ E
Sbjct: 1094 ISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERL 1153
Query: 905 ESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD-LSSKTQLL 963
E + N K ++F++L L+E + + + A L+++ +D ++ + +
Sbjct: 1154 EEAGGATSAQVELNKKR---EAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQI 1210
Query: 964 QDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVE 1023
++Q + + + +LK + +S+ E + K EK L +++ LK E
Sbjct: 1211 DNLQRVKQKLEKEKSELKMETDDLSSN---AEAISKAKGNLEKMCRSLEDQVSELKTKEE 1267
Query: 1024 HQRKKNNDLREKNWEAMEALASTEKMLQDK---VNKTSKERQQQVEAVELEAKEVLKKLF 1080
Q++ NDL + + L +K V++ S+ +Q + +E E K L++
Sbjct: 1268 EQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE-ELKHQLEE-- 1324
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGT--SGSEEVKVLEHKLKEADEMHTLLQLECEK 1138
E KAK +A S + +L + +E E LQ K
Sbjct: 1325 ------------------ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSK 1366
Query: 1139 YKSVLAE--TEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQELERLRS 1194
S +A+ T+ +QR+ E EE K K+ ++ E+ + ++ + + S E+ +RL++
Sbjct: 1367 ANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQN 1426
Query: 1195 ENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEE 1254
E +E+L + E + ++ + + E K E Q +L+ S E+ + E
Sbjct: 1427 E---VEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTE 1483
Query: 1255 LNLLKAQLNETLTKLRTEQNERQKVAGDLH----------KAQQSLELIQSKIVKAAGD- 1303
L +K E+L +L T + E + + ++ K LE I+ ++ + +
Sbjct: 1484 LFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEI 1543
Query: 1304 TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTK-EKEHYQVLE 1357
+E ++ S E E + + + LNQ +++ + + ++++ + ++ H +V+E
Sbjct: 1544 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598
Score = 69.7 bits (169), Expect = 2e-11
Identities = 144/740 (19%), Positives = 289/740 (39%), Gaps = 88/740 (11%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPR-DFKLSDALAVEDDQVAPVPLNVVETSSSVR 112
K+K EK+K++ K ++ +L S++E++ + L +DQV+ + E +
Sbjct: 1217 KQKLEKEKSELK-METDDL-SSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIN 1274
Query: 113 E-------------RKKKEKKQKPVLEEQVIKESDAS--KIPGKKVEPVPVTKQPTPPSE 157
+ ++ +K L Q+ + AS +I K + TK +
Sbjct: 1275 DLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAH 1334
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQ--------ETKQESGSGKK 209
A S + + ++Q+ K E SK + + + +E KK
Sbjct: 1335 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1394
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
K + + Q+ E H + + + + EV DL+ + +
Sbjct: 1395 KLAQRLQEAEE--------HVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL---------K 320
K + DK +E K K + ++ +L K K+ V +++L
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKN-VYEESLDQLETLRREN 1505
Query: 321 KSSKGELTTLIHQLQEKDKL---LAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
K+ + E++ L Q+ E K L +K+ K + +E E I R++
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Query: 378 DRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEI-AHLKQENGILR--DAVS 434
+ ++ E KI +E Q++ +V E M++ + A ++ N LR +
Sbjct: 1566 LELNQVKSE---VDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKME 1622
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAE 494
N++E +LN + A + G L++ ++ +A + LK QL E
Sbjct: 1623 GDLNEME----IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVE 1678
Query: 495 RRWEEVQSYIRKRTA---EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLM 551
RR +Q+ I + A + E +++ + + + VQ LH++ T + +K++LE +
Sbjct: 1679 RRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVS 1738
Query: 552 QLM----ESEQKRVNKEESLQMQVQDILEQNEALK------AQIQQFHSQIAAQTSASVL 601
QL E Q+ N EE + + D E LK A +++ + QT +
Sbjct: 1739 QLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLE-QTVKDLQ 1797
Query: 602 -----AEEL-----HKVIAEKDKQIKQTEDSLASERDR-------LTSKEEELKDIQNMN 644
AE+L K I + + ++++ E + +E+ R L E +K++
Sbjct: 1798 HRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQT 1857
Query: 645 FLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
+ V +LQ L ++ A ++ + + + +LQHE+ E I
Sbjct: 1858 EEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAE 1917
Query: 705 DQNKALKSEVQKLQTLVSEQ 724
Q L+ + +++ T +S +
Sbjct: 1918 SQVNKLRVKSREVHTKISAE 1937
Score = 42.0 bits (97), Expect = 0.004
Identities = 50/211 (23%), Positives = 87/211 (41%), Gaps = 22/211 (10%)
Query: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHK 1173
++K L + EM T+ + E +K K LA++E ++L E K + E +
Sbjct: 838 KIKPLLKSAETEKEMATMKE-EFQKTKDELAKSEAKRKEL-------EEKMVTLLKEKND 889
Query: 1174 TIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDL 1233
Q+QS S ER K+ L + + + E+ E + + R+L+D
Sbjct: 890 LQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDE 949
Query: 1234 LTELQKKLDD--------SYSEAVRQNEELNLLK--AQLNETLTKLRTE----QNERQKV 1279
+EL+K +DD + +N+ NL + A L+ET+ KL E Q Q+
Sbjct: 950 CSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQT 1009
Query: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENS 1310
DL + + ++ K +E S
Sbjct: 1010 LDDLQAEEDKVNILTKAKTKLEQQVDDLEGS 1040
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 171 bits (433), Expect = 4e-42
Identities = 242/1119 (21%), Positives = 474/1119 (42%), Gaps = 161/1119 (14%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 914 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1018
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1139 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1256 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1312
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------- 1361
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
+E + +++++ +K +QD ++AL+E G + +K + ++
Sbjct: 1362 --------------LERHISTLNIQLSDSKKKLQDFASTVEALEE--GKKRFQKEIE-NL 1404
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
T + +E E+ N ++ L++ DL N + + +L+++ Q +A+
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEK 1461
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
+ A + + E +EKE + L L+E L +K +L + NK+ K+++E
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEA---LEAKEEL----ERTNKMLKAEME 1514
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNW 1037
L + EL K E ++ + +L+ L+D E Q ++ LR E N
Sbjct: 1515 DLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNM 1569
Query: 1038 EAMEALASTEKMLQDKVNKTSKER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
+A++ + +D+ N+ + + Q+Q+ E E ++
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---------------------- 1607
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQ 1154
E+K + A K LE LK+ LE + ++ E I L+KLQ
Sbjct: 1608 --ERKQRALAAAAK-----KKLEGDLKD---------LELQADSAIKGREEAIKQLRKLQ 1651
Query: 1155 ---RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----ERE 1207
+ ++E + DE T K+ + S E +L +L+ + E R+ E+E
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
L EL + R+ E R L+ + +L+++L++ ++ + Q +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV------IENSDVSPE 1315
+L TE++ QK + ++ + ++SK+ VK+ +T+ I + E
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 1316 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1869
Score = 164 bits (415), Expect = 5e-40
Identities = 192/849 (22%), Positives = 400/849 (47%), Gaps = 58/849 (6%)
Query: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
+E E+Q+ +L T +Q+ E L +L E + ++ +E++L +Q+ L+ L A+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL---LQEQLQAETELYAE 905
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKDIQ 641
++ ++AA+ +EL +++ E + ++++ ED L +ER ++ + +L++
Sbjct: 906 AEEMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-- 957
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI-------RLLEEQLQHEIS 694
L+ E Q L E+ A +++K++ + V DD+ +LLEE++ +
Sbjct: 958 ----QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETG 754
N EE ++ K L K ++++SE + +++ EK QE ++ + +E
Sbjct: 1014 NLAEE----EEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
Q+A + ++ ++ + + +E+Q A+ +D++ A LKK I E +G I ++
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKK-IRELEGHISDLQ 1124
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK-VQELQNLLKGKE 873
E L++E EK +DL +E++ALK E+ + A Q + +K QE+ L K +
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE-ASSASQFEELE 932
E+ + +A ++E + A + L + E+ + KA++ + Q KE A A + L
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-NYQQASSF 991
+E E++ K+LEA ++E +S S + ++ D+ ++++E + N + +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 992 PPHEELLKVISEREKEISGLWNELD---SLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
+++ + S+ + L E ++ + ++ N L+++ E MEA + E+
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 1049 MLQD-KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
+ + + +++ Q A +EA E KK F K Y E ++K K
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK---T 1421
Query: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK 1167
+E+ L L ++ + L+ + K+ +LAE + I K ++ E + + K
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1168 VDESHKTIKQMQSSFTSSEQELERLRSENK-DIENLRREREHLEMELEKAEMERSTYVTE 1226
++ + ++ + + E ELER K ++E+L ++ + + + E + T+
Sbjct: 1482 ETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1227 VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNE--RQKVAGDLH 1284
+ E+K L EL+ +L + +R + LK Q L + R EQNE R+++ LH
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNEEKRRQLQRQLH 1599
Query: 1285 KAQQSLELIQSKIVKAAGDTTVIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342
+ + LE + + AA +E D+ + +S+ K + + QL++ LQA
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-----GREEAIKQLRK-LQAQ 1653
Query: 1343 NQQLTKEKE 1351
+ +E E
Sbjct: 1654 MKDFQRELE 1662
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1338 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1383
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1384 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1429
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1482
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1483 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1539
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1540 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1589 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1692
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1693 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1739
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1740 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1788
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1789 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1844 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1899
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1900 RRKLQRELDEATESNEAMGREVNALKSKLRR 1930
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 171 bits (433), Expect = 4e-42
Identities = 242/1119 (21%), Positives = 474/1119 (42%), Gaps = 161/1119 (14%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 921 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1025
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1146 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1263 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1319
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------- 1368
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
+E + +++++ +K +QD ++AL+E G + +K + ++
Sbjct: 1369 --------------LERHISTLNIQLSDSKKKLQDFASTVEALEE--GKKRFQKEIE-NL 1411
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
T + +E E+ N ++ L++ DL N + + +L+++ Q +A+
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEK 1468
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
+ A + + E +EKE + L L+E L +K +L + NK+ K+++E
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEA---LEAKEEL----ERTNKMLKAEME 1521
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNW 1037
L + EL K E ++ + +L+ L+D E Q ++ LR E N
Sbjct: 1522 DLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNM 1576
Query: 1038 EAMEALASTEKMLQDKVNKTSKER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
+A++ + +D+ N+ + + Q+Q+ E E ++
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---------------------- 1614
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQ 1154
E+K + A K LE LK+ LE + ++ E I L+KLQ
Sbjct: 1615 --ERKQRALAAAAK-----KKLEGDLKD---------LELQADSAIKGREEAIKQLRKLQ 1658
Query: 1155 ---RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----ERE 1207
+ ++E + DE T K+ + S E +L +L+ + E R+ E+E
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
L EL + R+ E R L+ + +L+++L++ ++ + Q +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV------IENSDVSPE 1315
+L TE++ QK + ++ + ++SK+ VK+ +T+ I + E
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 1316 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1876
Score = 164 bits (415), Expect = 5e-40
Identities = 192/849 (22%), Positives = 400/849 (47%), Gaps = 58/849 (6%)
Query: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
+E E+Q+ +L T +Q+ E L +L E + ++ +E++L +Q+ L+ L A+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL---LQEQLQAETELYAE 912
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKDIQ 641
++ ++AA+ +EL +++ E + ++++ ED L +ER ++ + +L++
Sbjct: 913 AEEMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-- 964
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI-------RLLEEQLQHEIS 694
L+ E Q L E+ A +++K++ + V DD+ +LLEE++ +
Sbjct: 965 ----QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETG 754
N EE ++ K L K ++++SE + +++ EK QE ++ + +E
Sbjct: 1021 NLAEE----EEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
Q+A + ++ ++ + + +E+Q A+ +D++ A LKK I E +G I ++
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKK-IRELEGHISDLQ 1131
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK-VQELQNLLKGKE 873
E L++E EK +DL +E++ALK E+ + A Q + +K QE+ L K +
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE-ASSASQFEELE 932
E+ + +A ++E + A + L + E+ + KA++ + Q KE A A + L
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-NYQQASSF 991
+E E++ K+LEA ++E +S S + ++ D+ ++++E + N + +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 992 PPHEELLKVISEREKEISGLWNELD---SLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
+++ + S+ + L E ++ + ++ N L+++ E MEA + E+
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 1049 MLQD-KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
+ + + +++ Q A +EA E KK F K Y E ++K K
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK---T 1428
Query: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK 1167
+E+ L L ++ + L+ + K+ +LAE + I K ++ E + + K
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1168 VDESHKTIKQMQSSFTSSEQELERLRSENK-DIENLRREREHLEMELEKAEMERSTYVTE 1226
++ + ++ + + E ELER K ++E+L ++ + + + E + T+
Sbjct: 1489 ETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1227 VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNE--RQKVAGDLH 1284
+ E+K L EL+ +L + +R + LK Q L + R EQNE R+++ LH
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNEEKRRQLQRQLH 1606
Query: 1285 KAQQSLELIQSKIVKAAGDTTVIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342
+ + LE + + AA +E D+ + +S+ K + + QL++ LQA
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-----GREEAIKQLRK-LQAQ 1660
Query: 1343 NQQLTKEKE 1351
+ +E E
Sbjct: 1661 MKDFQRELE 1669
Score = 73.9 bits (180), Expect = 9e-13
Identities = 137/691 (19%), Positives = 284/691 (41%), Gaps = 110/691 (15%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L + + E+ + + D++ E K+N ++ I N+ SDS+ +DF
Sbjct: 1345 LRQLEEERNSLQDQLDEEM-EAKQNLERHISTLNIQLSDSKKKLQDF------------- 1390
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
T ++ E KK+ +K+ L +Q +++ A + + TK
Sbjct: 1391 -------ASTVEALEEGKKRFQKEIENLTQQYEEKAAA-------YDKLEKTKNRLQQEL 1436
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQK 217
Q++ + + + +K + L+ K + +K + +A +++++
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK-------NISSKYADERDRAEAEAREKE 1489
Query: 218 TENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL--KPDQVEGIQKSGTKKLKTET 275
T+ + + L A + + + + + K E+ DL+ K D + + + K ET
Sbjct: 1490 TKALSLARALEEA---LEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALET 1546
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQ 335
E +KT + ++ L + K + V ALK + +L Q +
Sbjct: 1547 QME-----------EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 336 EKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
EK + L + + + E+ E+++ + K G L+ + I
Sbjct: 1596 EKRRQL----------QRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 396 VSYQETQQMQMKFQQVRE-QMEAEIAHLKQENGILRDAVSNTTNQLESKQ---SAELNKL 451
+ +Q++ Q+++ Q E E A RD + T + E K A+L +L
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARAS------RDEIFATAKENEKKAKSLEADLMQL 1699
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQL--KVQLQEAERRWEEVQSYIRKRTA 509
++D A E K L++EE+ AE+ A+ L + LQ+ +RR E R A
Sbjct: 1700 QEDLA--AAERARKQADLEKEEL----AEELASSLSGRNALQDEKRRLE-------ARIA 1746
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
+ E ++ Q A + V+ + QQ EQ L + +E+ K ES +
Sbjct: 1747 QLEEELEEEQGNMEAMSDRVRK----------ATQQAEQ-LSNELATERSTAQKNESARQ 1795
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q++ QN+ L++++ + + ++ +++ A L IA+ ++Q++Q +
Sbjct: 1796 QLE---RQNKELRSKLHEMEGAVKSKFKSTIAA--LEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 630 LTSKEEELKDIQNMNFLLKAEVQKLQALANEQA----AAAHELEKMQQSVYVKDDKIRLL 685
L K+++LK+I L + +K+ EQA A +L++ + + +I
Sbjct: 1851 LKQKDKKLKEI----LLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINAN 1906
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQK 716
+LQ E+ E + + + ALKS++++
Sbjct: 1907 RRKLQRELDEATESNEAMGREVNALKSKLRR 1937
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 171 bits (433), Expect = 4e-42
Identities = 242/1119 (21%), Positives = 474/1119 (42%), Gaps = 161/1119 (14%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 861 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 920
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 921 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 973
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 974 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1025
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1026 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1085
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1086 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1145
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1146 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1202
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1203 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1263 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1319
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------- 1368
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
+E + +++++ +K +QD ++AL+E G + +K + ++
Sbjct: 1369 --------------LERHISTLNIQLSDSKKKLQDFASTVEALEE--GKKRFQKEIE-NL 1411
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
T + +E E+ N ++ L++ DL N + + +L+++ Q +A+
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEK 1468
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
+ A + + E +EKE + L L+E L +K +L + NK+ K+++E
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEA---LEAKEEL----ERTNKMLKAEME 1521
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNW 1037
L + EL K E ++ + +L+ L+D E Q ++ LR E N
Sbjct: 1522 DLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNM 1576
Query: 1038 EAMEALASTEKMLQDKVNKTSKER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
+A++ + +D+ N+ + + Q+Q+ E E ++
Sbjct: 1577 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---------------------- 1614
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQ 1154
E+K + A K LE LK+ LE + ++ E I L+KLQ
Sbjct: 1615 --ERKQRALAAAAK-----KKLEGDLKD---------LELQADSAIKGREEAIKQLRKLQ 1658
Query: 1155 ---RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----ERE 1207
+ ++E + DE T K+ + S E +L +L+ + E R+ E+E
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
L EL + R+ E R L+ + +L+++L++ ++ + Q +
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV------IENSDVSPE 1315
+L TE++ QK + ++ + ++SK+ VK+ +T+ I + E
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 1316 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1876
Score = 164 bits (415), Expect = 5e-40
Identities = 192/849 (22%), Positives = 400/849 (47%), Gaps = 58/849 (6%)
Query: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
+E E+Q+ +L T +Q+ E L +L E + ++ +E++L +Q+ L+ L A+
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL---LQEQLQAETELYAE 912
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKDIQ 641
++ ++AA+ +EL +++ E + ++++ ED L +ER ++ + +L++
Sbjct: 913 AEEMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-- 964
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI-------RLLEEQLQHEIS 694
L+ E Q L E+ A +++K++ + V DD+ +LLEE++ +
Sbjct: 965 ----QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1020
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETG 754
N EE ++ K L K ++++SE + +++ EK QE ++ + +E
Sbjct: 1021 NLAEE----EEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
Q+A + ++ ++ + + +E+Q A+ +D++ A LKK I E +G I ++
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKK-IRELEGHISDLQ 1131
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK-VQELQNLLKGKE 873
E L++E EK +DL +E++ALK E+ + A Q + +K QE+ L K +
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE-ASSASQFEELE 932
E+ + +A ++E + A + L + E+ + KA++ + Q KE A A + L
Sbjct: 1192 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1251
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-NYQQASSF 991
+E E++ K+LEA ++E +S S + ++ D+ ++++E + N + +
Sbjct: 1252 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 992 PPHEELLKVISEREKEISGLWNELD---SLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
+++ + S+ + L E ++ + ++ N L+++ E MEA + E+
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 1049 MLQD-KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
+ + + +++ Q A +EA E KK F K Y E ++K K
Sbjct: 1372 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK---T 1428
Query: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK 1167
+E+ L L ++ + L+ + K+ +LAE + I K ++ E + + K
Sbjct: 1429 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1488
Query: 1168 VDESHKTIKQMQSSFTSSEQELERLRSENK-DIENLRREREHLEMELEKAEMERSTYVTE 1226
++ + ++ + + E ELER K ++E+L ++ + + + E + T+
Sbjct: 1489 ETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1547
Query: 1227 VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNE--RQKVAGDLH 1284
+ E+K L EL+ +L + +R + LK Q L + R EQNE R+++ LH
Sbjct: 1548 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNEEKRRQLQRQLH 1606
Query: 1285 KAQQSLELIQSKIVKAAGDTTVIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342
+ + LE + + AA +E D+ + +S+ K + + QL++ LQA
Sbjct: 1607 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-----GREEAIKQLRK-LQAQ 1660
Query: 1343 NQQLTKEKE 1351
+ +E E
Sbjct: 1661 MKDFQRELE 1669
Score = 117 bits (292), Expect = 1e-25
Identities = 214/1061 (20%), Positives = 446/1061 (42%), Gaps = 133/1061 (12%)
Query: 63 KKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV---VETSSSVRERKKKEK 119
KK+E++ LHE ++ + + L E ++A L++ +E + R++ + EK
Sbjct: 923 KKQELEE-ILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 980
Query: 120 -----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG 173
K K + +E ++ + +K+ +K+ ++ T +E K + K+K+
Sbjct: 981 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1040
Query: 174 SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK-----ASSKKQKTENVFVDEPLI 228
S + +V RQE L ++ + ++ ++ A + K + +E L
Sbjct: 1041 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1100
Query: 229 HATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKEN-AEVKFKDF 287
A + + K + ++ ++EG + L +E N AE + +D
Sbjct: 1101 AALARL-------DDEIAQKNNALKKIR--ELEGHISDLQEDLDSERAARNKAEKQKRDL 1151
Query: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
L+ + ++ L S Q L+ + E+T L L E+ + A ++
Sbjct: 1152 GEELEALKTELEDTL--------DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
+ + E + + +R+ + + K TLEKE+ ++ V Q Q+++ K
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQ---TLEKENADLAGELRVLGQAKQEVEHK 1260
Query: 408 FQQVREQ---MEAEIAHLKQENGILRDAVSNTTNQLES------KQSAELNKLRQDYARL 458
+++ Q ++++ + ++ L D V N++ES + + KL +D A L
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
++L + LQ+E QK N QL EE ++ ++ + E A+Q+L
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQL-----------EEERNSLQDQLDEEMEAKQNL 1369
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKE-ESLQMQVQD-- 573
E + +L+ +L+D SK++L+ ++ +E +KR KE E+L Q ++
Sbjct: 1370 -------ERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 574 -ILEQNEALKAQIQQFHSQIAAQT-SASVLAEELHKVIAEKDKQI---KQTEDSLASERD 628
++ E K ++QQ + + L L K + D+ + K A ERD
Sbjct: 1420 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 629 RLTS--KEEELK----------------DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
R + +E+E K +++ N +LKAE++ L + ++ HELEK
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
++++ + ++++ E+L+ E+ + L +ALK + ++ EQ N++
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ-NEEKR 1598
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTK----EVQDLKA 784
Q+++ + E + +L+ +E + L A K E +L + + S K ++ L+
Sbjct: 1599 RQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 785 KQNDQVSFASLVE-------ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE 837
Q F +E E+ E + K KS LEA+L+++ + +++
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKS----LEADLMQLQEDLAAAERARKQ 1712
Query: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKD 889
KEE+ E A LS + +Q+ + L+ + EE+ M+A+ + K
Sbjct: 1713 ADLEKEELAE---ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1769
Query: 890 LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAM 948
+ +L E + + + Q + S+ E+E +K K ++ + LEA
Sbjct: 1770 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 949 LKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
+ + E + + + Q K +++++ Q + ++E + + R K++
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1889
Query: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM 1049
L++A E ++ N + R+ E EA S E M
Sbjct: 1890 K------RQLEEAEEESQRINANRRKLQRELDEATESNEAM 1924
Score = 115 bits (288), Expect = 3e-25
Identities = 196/948 (20%), Positives = 388/948 (40%), Gaps = 128/948 (13%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAP 99
K K E + + KK EK + + ++++ KL + +Q+A
Sbjct: 1036 KNKHESMISELEVRLKKEEKSRQELEKLKR---------------KLEGDASDFHEQIAD 1080
Query: 100 VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAA 159
+ + E + +++++ + L++++ ++++A K +++E Q SE A
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERA 1139
Query: 160 ASKKKPGQKKSKNGS---------DDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKK 209
A K QK+ D D + +KR QE L + +E+ S +
Sbjct: 1140 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1199
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGT- 268
+ +QK V+E + N D + ++E DL +V G K
Sbjct: 1200 QVQEMRQKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1258
Query: 269 ---KKLKTE--------TDKENAEVKFKDFLLSLK------TMMFSEDEALCV-----VD 306
KKL+ + +D E A + D + L+ T M +E E + V
Sbjct: 1259 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1318
Query: 307 LLKEKSGVIQDALKKSSKGEL--TTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
L + Q+ L++ ++ +L +T + QL+E+ L ++ K ++ +
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378
Query: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIH---VSYQETQQMQMKFQQVREQMEAEIAH 421
+ S + + LE+ FQ +I Y+E K ++ + +++ E+
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1438
Query: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
L + R VSN LE KQ K Q A N ++ + + E + + E
Sbjct: 1439 LVVDLDNQRQLVSN----LEKKQ----RKFDQLLAEEKNISSKYADERDRAEAEAREKET 1490
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHE---AAQQDLQSKFVAKENEVQSLHSKLTD 538
A L L+EA EE++ + AE E +++ D+ E ++L +++ +
Sbjct: 1491 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1550
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQ---------MQVQDILEQNEALKAQIQ--- 586
K QLE+ +L +E ++ E ++Q +Q +D EQNE + Q+Q
Sbjct: 1551 M---KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQL 1605
Query: 587 -QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELKDIQ 641
++ +++ + LA K + K ++ DS R+ +L + ++KD Q
Sbjct: 1606 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1665
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKD---DKIRLLEEQLQHEIS 694
+A ++ A A E A LE ++Q+ + + + L +E+L E++
Sbjct: 1666 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1725
Query: 695 NKMEEFKILNDQNKALKSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
+ + L D+ + L++ + +L+ L EQ N + + + ++ E+L
Sbjct: 1726 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------- 1778
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
++AT+ + L ++ ++L++K ++ ++ + K I + KI +
Sbjct: 1779 ---ELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTIAALEAKIAQL 1833
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-------KAQQLSITSKVQELQ 866
EE +E E K+ + LKQ+ K LKE + V+ E K Q ++V++L+
Sbjct: 1834 EEQVEQE---AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1890
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
L+ E EE ++ AN K ++L E ES +A +EV
Sbjct: 1891 RQLEEAE----------EESQRINANRRKLQRELDEATESNEAMGREV 1928
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 171 bits (433), Expect = 4e-42
Identities = 242/1119 (21%), Positives = 474/1119 (42%), Gaps = 161/1119 (14%)
Query: 294 MMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQLQEKDKLLAAVKE---DA 348
M EDE + ++ +++ +K S+ E L QLQ + +L A +E
Sbjct: 854 MQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRL 913
Query: 349 AATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNK---IHVSYQETQQMQ 405
AA K +++ EM E +DR L+ E + + +E + +
Sbjct: 914 AAKKQELEEILHEMEARLEEE-------EDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR 966
Query: 406 MKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEK 465
K Q + EA+I L+ E ++ D +K S E L + + L L E+
Sbjct: 967 QKLQLEKVTAEAKIKKLEDEILVMDDQ--------NNKLSKERKLLEERISDLTTNLAEE 1018
Query: 466 TGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRK----------RTAEHEAAQ 515
K + K E ++L+V+L++ E+ +E++ RK + A+ +A
Sbjct: 1019 EEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQI 1078
Query: 516 QDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQL----------MESEQKRVNKEE 565
+L+ + KE E+Q+ ++L D + K +++ +L ++SE+ NK E
Sbjct: 1079 AELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAE 1138
Query: 566 SLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEK-DKQIKQTEDSLA 624
Q +D+ E+ EALK +++ A Q E+ V+ + D++ + E +
Sbjct: 1139 K---QKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQ 1195
Query: 625 SERDRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIR 683
R + EEL + KA + K Q L E A A EL + Q+ + K +
Sbjct: 1196 EMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 684 LLEEQLQHEISNKMEEFKI----LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQE 739
LE Q+Q E+ +K + + LND+ L++EV+ + +++E K + ++ K +
Sbjct: 1256 KLEAQVQ-ELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI--KLAKDVAS 1312
Query: 740 KDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEV-QDLKAKQNDQVSFASLVEE 798
+L+ +ELL+ Q +L + E +SL ++ ++++AKQN
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQN----------- 1361
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSI 858
+E + +++++ +K +QD ++AL+E G + +K + ++
Sbjct: 1362 --------------LERHISTLNIQLSDSKKKLQDFASTVEALEE--GKKRFQKEIE-NL 1404
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHN 918
T + +E E+ N ++ L++ DL N + + +L+++ Q +A+
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFD---QLLAEEK 1461
Query: 919 LKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIE 978
+ A + + E +EKE + L L+E L +K +L + NK+ K+++E
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEA---LEAKEEL----ERTNKMLKAEME 1514
Query: 979 QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLR-EKNW 1037
L + EL K E ++ + +L+ L+D E Q ++ LR E N
Sbjct: 1515 DLVSSKDDVGKNV---HELEKSKRALETQMEEMKTQLEELED--ELQATEDAKLRLEVNM 1569
Query: 1038 EAMEALASTEKMLQDKVNKTSKER-QQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
+A++ + +D+ N+ + + Q+Q+ E E ++
Sbjct: 1570 QALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELED---------------------- 1607
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI--LQKLQ 1154
E+K + A K LE LK+ LE + ++ E I L+KLQ
Sbjct: 1608 --ERKQRALAAAAK-----KKLEGDLKD---------LELQADSAIKGREEAIKQLRKLQ 1651
Query: 1155 ---RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRR----ERE 1207
+ ++E + DE T K+ + S E +L +L+ + E R+ E+E
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLT 1267
L EL + R+ E R L+ + +L+++L++ ++ + Q +
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 1268 KLRTEQNERQKVAGDLHKAQQSLELIQSKI------VKAAGDTTV------IENSDVSPE 1315
+L TE++ QK + ++ + ++SK+ VK+ +T+ I + E
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 1316 TESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQ 1354
E+ EK+ + SL Q +L+++L V + K E Y+
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDE-RKMAEQYK 1869
Score = 164 bits (415), Expect = 5e-40
Identities = 192/849 (22%), Positives = 400/849 (47%), Gaps = 58/849 (6%)
Query: 525 KENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
+E E+Q+ +L T +Q+ E L +L E + ++ +E++L +Q+ L+ L A+
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKEL-EQKHSQLTEEKNL---LQEQLQAETELYAE 905
Query: 585 IQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED---SLASERDRLTSKEEELKDIQ 641
++ ++AA+ +EL +++ E + ++++ ED L +ER ++ + +L++
Sbjct: 906 AEEMRVRLAAKK------QELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE-- 957
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI-------RLLEEQLQHEIS 694
L+ E Q L E+ A +++K++ + V DD+ +LLEE++ +
Sbjct: 958 ----QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETG 754
N EE ++ K L K ++++SE + +++ EK QE ++ + +E
Sbjct: 1014 NLAEE----EEKAKNLTKLKNKHESMISELEVR--LKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 755 LIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE 814
Q+A + ++ ++ + + +E+Q A+ +D++ A LKK I E +G I ++
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEI--AQKNNALKK-IRELEGHISDLQ 1124
Query: 815 ELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK-VQELQNLLKGKE 873
E L++E EK +DL +E++ALK E+ + A Q + +K QE+ L K +
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE-ASSASQFEELE 932
E+ + +A ++E + A + L + E+ + KA++ + Q KE A A + L
Sbjct: 1185 EETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG 1244
Query: 933 IVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQ-NYQQASSF 991
+E E++ K+LEA ++E +S S + ++ D+ ++++E + N + +
Sbjct: 1245 QAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 992 PPHEELLKVISEREKEISGLWNELD---SLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
+++ + S+ + L E ++ + ++ N L+++ E MEA + E+
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 1049 MLQD-KVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
+ + + +++ Q A +EA E KK F K Y E ++K K
Sbjct: 1365 HISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEK---T 1421
Query: 1108 GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVK 1167
+E+ L L ++ + L+ + K+ +LAE + I K ++ E + + K
Sbjct: 1422 KNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREK 1481
Query: 1168 VDESHKTIKQMQSSFTSSEQELERLRSENK-DIENLRREREHLEMELEKAEMERSTYVTE 1226
++ + ++ + + E ELER K ++E+L ++ + + + E + T+
Sbjct: 1482 ETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQ 1540
Query: 1227 VRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNE--RQKVAGDLH 1284
+ E+K L EL+ +L + +R + LK Q L + R EQNE R+++ LH
Sbjct: 1541 MEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDL-QARDEQNEEKRRQLQRQLH 1599
Query: 1285 KAQQSLELIQSKIVKAAGDTTVIEN--SDVSPETESSEKETMSVSLNQTVTQLQQLLQAV 1342
+ + LE + + AA +E D+ + +S+ K + + QL++ LQA
Sbjct: 1600 EYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-----GREEAIKQLRK-LQAQ 1653
Query: 1343 NQQLTKEKE 1351
+ +E E
Sbjct: 1654 MKDFQRELE 1662
Score = 117 bits (292), Expect = 1e-25
Identities = 214/1061 (20%), Positives = 446/1061 (42%), Gaps = 133/1061 (12%)
Query: 63 KKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV---VETSSSVRERKKKEK 119
KK+E++ LHE ++ + + L E ++A L++ +E + R++ + EK
Sbjct: 916 KKQELEE-ILHEMEARLEEEEDR-GQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEK 973
Query: 120 -----KQKPVLEEQVIKESDASKIPG-KKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNG 173
K K + +E ++ + +K+ +K+ ++ T +E K + K+K+
Sbjct: 974 VTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE 1033
Query: 174 SDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKK-----ASSKKQKTENVFVDEPLI 228
S + +V RQE L ++ + ++ ++ A + K + +E L
Sbjct: 1034 SMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQ 1093
Query: 229 HATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKEN-AEVKFKDF 287
A + + K + ++ ++EG + L +E N AE + +D
Sbjct: 1094 AALARL-------DDEIAQKNNALKKIR--ELEGHISDLQEDLDSERAARNKAEKQKRDL 1144
Query: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
L+ + ++ L S Q L+ + E+T L L E+ + A ++
Sbjct: 1145 GEELEALKTELEDTL--------DSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
+ + E + + +R+ + + K TLEKE+ ++ V Q Q+++ K
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQ---TLEKENADLAGELRVLGQAKQEVEHK 1253
Query: 408 FQQVREQ---MEAEIAHLKQENGILRDAVSNTTNQLES------KQSAELNKLRQDYARL 458
+++ Q ++++ + ++ L D V N++ES + + KL +D A L
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
++L + LQ+E QK N QL EE ++ ++ + E A+Q+L
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQL-----------EEERNSLQDQLDEEMEAKQNL 1362
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQ--RLMQLMESEQKRVNKE-ESLQMQVQD-- 573
E + +L+ +L+D SK++L+ ++ +E +KR KE E+L Q ++
Sbjct: 1363 -------ERHISTLNIQLSD---SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 574 -ILEQNEALKAQIQQFHSQIAAQT-SASVLAEELHKVIAEKDKQI---KQTEDSLASERD 628
++ E K ++QQ + + L L K + D+ + K A ERD
Sbjct: 1413 AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 629 RLTS--KEEELK----------------DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
R + +E+E K +++ N +LKAE++ L + ++ HELEK
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 671 MQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
++++ + ++++ E+L+ E+ + L +ALK + ++ EQ N++
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQ-NEEKR 1591
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATK--EEELNAIRTENSSLTK----EVQDLKA 784
Q+++ + E + +L+ +E + L A K E +L + + S K ++ L+
Sbjct: 1592 RQLQRQLHEYETELE--DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 785 KQNDQVSFASLVE-------ELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQE 837
Q F +E E+ E + K KS LEA+L+++ + +++
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKS----LEADLMQLQEDLAAAERARKQ 1705
Query: 838 IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGK--------EEQMNTMKAVLEEKEKD 889
KEE+ E A LS + +Q+ + L+ + EE+ M+A+ + K
Sbjct: 1706 ADLEKEELAE---ELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKA 1762
Query: 890 LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEK-ENELKRLEAM 948
+ +L E + + + Q + S+ E+E +K K ++ + LEA
Sbjct: 1763 TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 949 LKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEI 1008
+ + E + + + Q K +++++ Q + ++E + + R K++
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQL 1882
Query: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM 1049
L++A E ++ N + R+ E EA S E M
Sbjct: 1883 K------RQLEEAEEESQRINANRRKLQRELDEATESNEAM 1917
Score = 115 bits (288), Expect = 3e-25
Identities = 196/948 (20%), Positives = 388/948 (40%), Gaps = 128/948 (13%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAP 99
K K E + + KK EK + + ++++ KL + +Q+A
Sbjct: 1029 KNKHESMISELEVRLKKEEKSRQELEKLKR---------------KLEGDASDFHEQIAD 1073
Query: 100 VPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAA 159
+ + E + +++++ + L++++ ++++A K +++E Q SE A
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALK-KIRELEGHISDLQEDLDSERA 1132
Query: 160 ASKKKPGQKKSKNGS---------DDQDKKVETLMVPSKR-QEALPLHQETKQESGSGKK 209
A K QK+ D D + +KR QE L + +E+ S +
Sbjct: 1133 ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEA 1192
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGT- 268
+ +QK V+E + N D + ++E DL +V G K
Sbjct: 1193 QVQEMRQKHAQA-VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVE 1251
Query: 269 ---KKLKTE--------TDKENAEVKFKDFLLSLK------TMMFSEDEALCV-----VD 306
KKL+ + +D E A + D + L+ T M +E E + V
Sbjct: 1252 HKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVA 1311
Query: 307 LLKEKSGVIQDALKKSSKGEL--TTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMT 364
L + Q+ L++ ++ +L +T + QL+E+ L ++ K ++ +
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371
Query: 365 EKERSNVVITRMKDRIGTLEKEHNVFQNKIH---VSYQETQQMQMKFQQVREQMEAEIAH 421
+ S + + LE+ FQ +I Y+E K ++ + +++ E+
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDD 1431
Query: 422 LKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQ 481
L + R VSN LE KQ K Q A N ++ + + E + + E
Sbjct: 1432 LVVDLDNQRQLVSN----LEKKQ----RKFDQLLAEEKNISSKYADERDRAEAEAREKET 1483
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHE---AAQQDLQSKFVAKENEVQSLHSKLTD 538
A L L+EA EE++ + AE E +++ D+ E ++L +++ +
Sbjct: 1484 KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEE 1543
Query: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQ---------MQVQDILEQNEALKAQIQ--- 586
K QLE+ +L +E ++ E ++Q +Q +D EQNE + Q+Q
Sbjct: 1544 M---KTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD--EQNEEKRRQLQRQL 1598
Query: 587 -QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERD----RLTSKEEELKDIQ 641
++ +++ + LA K + K ++ DS R+ +L + ++KD Q
Sbjct: 1599 HEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQ 1658
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHELE----KMQQSVYVKD---DKIRLLEEQLQHEIS 694
+A ++ A A E A LE ++Q+ + + + L +E+L E++
Sbjct: 1659 RELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELA 1718
Query: 695 NKMEEFKILNDQNKALKSEVQKLQT-LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
+ + L D+ + L++ + +L+ L EQ N + + + ++ E+L
Sbjct: 1719 SSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN------- 1771
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
++AT+ + L ++ ++L++K ++ ++ + K I + KI +
Sbjct: 1772 ---ELATERSTAQKNESARQQLERQNKELRSKLHEMEG--AVKSKFKSTIAALEAKIAQL 1826
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE-------KAQQLSITSKVQELQ 866
EE +E E K+ + LKQ+ K LKE + V+ E K Q ++V++L+
Sbjct: 1827 EEQVEQE---AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLK 1883
Query: 867 NLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEV 914
L+ E EE ++ AN K ++L E ES +A +EV
Sbjct: 1884 RQLEEAE----------EESQRINANRRKLQRELDEATESNEAMGREV 1921
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 169 bits (429), Expect = 1e-41
Identities = 213/1113 (19%), Positives = 491/1113 (44%), Gaps = 127/1113 (11%)
Query: 326 ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNV-------------- 371
++T +LQ KD+ L VKE + +++ ++ E N+
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 372 -----------------VITRMKDRIGTLEKEHNVFQN-----KIHVSYQETQ------- 402
++ ++ R+ E+ + + QN + H+ E Q
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 403 QMQMKFQQVR-----EQMEAEIAHLKQENG-------ILRDAVSNTTNQL--ESKQSAEL 448
+ +++ ++V ++ME EI L+ +N ++ D ++ ++QL E +++ L
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNL 1025
Query: 449 NKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRT 508
K+R ++++L E +L++EE ++ E+A +L + + + + E+Q+ I +
Sbjct: 1026 AKIRNKQEVMISDLEE---RLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELK 1082
Query: 509 AEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQ 568
+ +++LQ ++E +LH + L ++L+ ++ +L E + +
Sbjct: 1083 LQLAKKEEELQGALARGDDE--TLHK--NNALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 569 MQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER 627
Q +D+ E+ EALK +++ AAQ E E+ ++ +++ K E + R
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 628 DRLTSKEEELKDIQNMNFLLKAEVQK-LQALANEQAAAAHELEKMQQSVYVKDDKIRLLE 686
R + EEL + KA ++K Q L + A E++ +QQ + K + L+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 687 EQLQ--HEISNKMEEFKI-LNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
Q+Q H ++ + ++ L ++ L++E+ + TL+ E K + + K + +
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGI--KFAKDAASLESQ 1316
Query: 744 LKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQD----LKAKQNDQVSFASLVEEL 799
L+ +ELL+ Q + + E +SL ++ ++ K + ++ S + +
Sbjct: 1317 LQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADT 1376
Query: 800 KKVIHEKDGKIKSVEE-----LLEAELLKVANKEKTV--QDLKQEIKALKEEIGNVQLEK 852
KK + + G I+S+EE L +AE L +EK + L++ L++E+ ++ ++
Sbjct: 1377 KKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDL 1436
Query: 853 AQQLSITSKVQELQ---NLLKGKE--------EQMNTMKAVLEEKEKDLANTGKWL---- 897
Q + S +++ Q + L +E E+ + +A EKE + + L
Sbjct: 1437 DHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEAL 1496
Query: 898 ---QDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELK-RLEAMLKERE 953
++ + +N+ L+A ++++ + + E+ + L+++ E++ +LE + E +
Sbjct: 1497 EAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQ 1556
Query: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWN 1013
+ +K +L ++Q F+ ++ +QN ++ L+K + E E E+ +
Sbjct: 1557 ATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK------KRLLIKQVRELEAELE---D 1607
Query: 1014 ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK 1073
E AV ++K DL++ +EA +D+V K ++ Q Q++ + E +
Sbjct: 1608 ERKQRALAVASKKKMEIDLKD-----LEAQIEAANKARDEVIKQLRKLQAQMKDYQRELE 1662
Query: 1074 EVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQ 1133
E + ++ S S + L E + + + SE + H +E DE+ +
Sbjct: 1663 EA-RASRDEIFAQSKESEKK-LKSLEAEILQLQEELASSERAR--RHAEQERDELADEIT 1718
Query: 1134 LECEKYKSVLAE---TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELE 1190
++L E E + +L+ +E+E++ ++ D KT Q+ + ++E E
Sbjct: 1719 NSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDT--LNAELAAE 1776
Query: 1191 RLRSENKDIENLRREREHLEMELEKAEME---RSTYVTEVRELKDLLTELQKKLDDSYSE 1247
R ++ D + ER++ E++ + E+E +S + + L+ + +L+++L+ E
Sbjct: 1777 RSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKE 1836
Query: 1248 AVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVI 1307
N+ + + +L E ++ E+ + + KA ++ ++ ++ +A + T
Sbjct: 1837 RAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRA 1896
Query: 1308 ENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ 1340
S + E + + L++ V+ L+ L+
Sbjct: 1897 NASRRKLQRELDDATEANEGLSREVSTLKNRLR 1929
Score = 163 bits (413), Expect = 9e-40
Identities = 251/1173 (21%), Positives = 502/1173 (42%), Gaps = 166/1173 (14%)
Query: 261 EGIQKSGTKKLKTETDKENAEVKFKDFL---------LSLKTMMFSEDEALCV------- 304
E + K K+ K E + E E K + L L +T +F+E E +
Sbjct: 859 EELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQ 918
Query: 305 ------------VDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
V+ +E++ ++Q+ KK + + L QL E++ ++ + +
Sbjct: 919 ELEEILHDLESRVEEEEERNQILQNE-KKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAE 977
Query: 353 DRCKQLTQEMMTEKERSNVVITR---MKDRIGTL--------EKEHNV--FQNKIHVSYQ 399
+ K++ +E++ +++++ I M+DRI EK N+ +NK V
Sbjct: 978 AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS 1037
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV 459
+ ++ K ++ R+++E L E L+D ++ A++++L+ A+
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAEL--------QAQIDELKLQLAKKE 1089
Query: 460 NELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQ 519
EL + E + K NA + +L+ Q+ E + +E ++ K E ++DL
Sbjct: 1090 EELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKA----EKQKRDLS 1145
Query: 520 SKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKE-ESLQMQVQDI---- 574
+ A + E++ DT ++Q+L + Q + +K + +E ++ + Q+QD+
Sbjct: 1146 EELEALKTELEDT----LDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 575 ----------LEQNEALKAQIQQFHSQIAAQTSASVLAEE---LHKVIAEKDKQIKQTED 621
LEQ + KA +++ ++ +T LA E L +V AE + + K+ +
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEK--NKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 622 SL------ASERDRL----TSKEEELK-DIQNMNFLLKAEVQKLQALANEQAAAAHELEK 670
+ SE DRL K +L+ ++ N++ LL+ +K A + A+ +L+
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 671 MQQSVYVKD-DKIRLLEE--QLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK 727
Q+ + + K+ L QL+ E ++ E+ + + K L+ +V LQ+ +++ K
Sbjct: 1320 TQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKK 1379
Query: 728 --DVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK 785
D + +E + K + LK E L + ++ K + + + L +E+ DL
Sbjct: 1380 VDDDLGTIESLEEAKKKLLKDAEALSQ----RLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 786 QNDQVSFASLVEELKKVIHEKDGKIKSVE-------ELLEAELLKVANKEKTVQDLKQEI 838
+ Q AS +E+ +K + + KS+ + EAE + K ++ +E
Sbjct: 1436 LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEA 1495
Query: 839 KALKEEIG--NVQLEKAQQLSITSK------VQELQNLLKGKEEQMNTMKAVLEEKEKDL 890
KEE N QL + ++SK V EL+ + E+Q+ M+ LEE E +L
Sbjct: 1496 LEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDEL 1555
Query: 891 ANTGKWLQDLQEENESLKAHVQEVAQ-----HNLKEASSASQFEELEIVLKEKENEL--- 942
T L+ +++KA + Q + K+ Q ELE L+++ +
Sbjct: 1556 QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615
Query: 943 ----KRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS----FPPH 994
K++E LK+ E+ + + + +V + + ++Q++ +++ + +S F
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQS 1675
Query: 995 EELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK---NWEAMEALASTEKMLQ 1051
+E K + E EI L EL S + A H ++ ++L ++ + AL ++ L+
Sbjct: 1676 KESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLE 1735
Query: 1052 DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSG 1111
++ + +E +++ +EL L F K ++ + E K A
Sbjct: 1736 ARIAQLEEELEEEQSNMEL-----LNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQL 1790
Query: 1112 SEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
+ K L+ KL+E + K+K+ ++ E + +L+ +EQE +
Sbjct: 1791 ERQNKELKAKLQELEGAVK------SKFKATISALEAKIGQLEEQLEQEAKERAAANKLV 1844
Query: 1172 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK 1231
+T K+++ F E E + +E + L+ +LE+AE E +T R
Sbjct: 1845 RRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAE-EEATRANASRR-- 1901
Query: 1232 DLLTELQKKLDDSYSEAVRQNEELNLLKAQLNE--TLTKLRTEQNERQKVAGDLHKAQQS 1289
+LQ++LDD+ + E++ LK +L ++ + RQ LH S
Sbjct: 1902 ----KLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRRQ-----LHLEGAS 1952
Query: 1290 LELIQSKIVKAAGDTTVIENSDVSPETESSEKE 1322
LEL + D T + SDV+ ET+ + E
Sbjct: 1953 LEL--------SDDDTESKTSDVN-ETQPPQSE 1976
Score = 160 bits (404), Expect = 1e-38
Identities = 198/918 (21%), Positives = 402/918 (43%), Gaps = 130/918 (14%)
Query: 544 QQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAE 603
Q ++ L+++ E + K + E ++ + Q +LE+ L Q+Q A+T AE
Sbjct: 855 QAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ-------AETELFAEAE 907
Query: 604 ELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAA 663
E+ +A K +++++ L S R+ +EE + +QN ++A +Q L+ +E+
Sbjct: 908 EMRARLAAKKQELEEILHDLES---RVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEG 964
Query: 664 AAHELEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQ----NKALKSEVQK 716
A +K+Q + KI+ +EE+ L+ + S ++E K++ D+ + L E +K
Sbjct: 965 AR---QKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1021
Query: 717 LQTLVSEQPNKDV--------VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAI 768
+ L + ++V +++ EK QE ++ + ++ Q+A + +++ +
Sbjct: 1022 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 769 RTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE 828
+ + + +E+Q A+ +D+ + KV+ E +I ++E E+E E
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKN---NALKVVRELQAQIAELQEDFESEKASRNKAE 1138
Query: 829 KTVQDLKQEIKALKEEI-GNVQLEKAQQLSITSKVQELQNLLKGKEEQ------------ 875
K +DL +E++ALK E+ + AQQ T + QE+ L K EE+
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 876 ------MNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQ------HNLKEA- 922
+ + LE+ ++ AN K Q L+ +N+ L V+ + Q H K+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 923 -------SSASQFEELEIVLKEK----ENELKRLEAMLKER--------------ESDLS 957
+ S+ + L + L EK +NEL + +L+E ES L
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 958 SKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017
+LLQ+ + S+I QL+++ EE K + EK++ L ++L
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL---EKQVLALQSQLAD 1375
Query: 1018 LKDAVEHQRKKNNDLRE------KNWEAMEALASTEKMLQDKVNKTSKERQQQVE----- 1066
K V+ L E K+ EA+ + + DK+ KT QQ+++
Sbjct: 1376 TKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD 1435
Query: 1067 -------AVELEAKEVLKKLFPKVSVPSNLS--YGEWLHGFEKKAKECMAGTSGSEEVKV 1117
A LE K+ KK ++ ++S Y E E +A+E T +
Sbjct: 1436 LDHQRQVASNLEKKQ--KKFDQLLAEEKSISARYAEERDRAEAEARE--KETKALSLARA 1491
Query: 1118 LEHKL---KEADEMHTLLQLECE---KYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
LE L +E + + L+ + E K + + L+K +R++EQ+ + + +++E
Sbjct: 1492 LEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEEL 1551
Query: 1172 HKTIK-----------QMQSSFTSSEQELERLRSENKDIENLR-REREHLEMELEKAEME 1219
++ MQ+ E++L+ +N++ + L ++ LE ELE +
Sbjct: 1552 EDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611
Query: 1220 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKV 1279
R+ V ++++ L +L+ +++ + ++L L+AQ+ + +L + R ++
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSE---KETMSVSLNQTVTQLQ 1336
++++ L+ ++++I++ + E + E E E + T S S + +
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEK 1731
Query: 1337 QLLQAVNQQLTKEKEHYQ 1354
+ L+A QL +E E Q
Sbjct: 1732 RRLEARIAQLEEELEEEQ 1749
Score = 135 bits (340), Expect = 3e-31
Identities = 176/839 (20%), Positives = 361/839 (43%), Gaps = 119/839 (14%)
Query: 609 IAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHEL 668
+ ++++++ ++ L +++ T E EL++++ + L E L + E
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 669 EKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD 728
E+M+ + K ++ + L+ + + E +IL ++ K +++ +Q L+ + E+
Sbjct: 907 EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGAR 966
Query: 729 VVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKE---VQDLKAK 785
Q+EK E ++ EEE+ + +NS KE ++D A+
Sbjct: 967 QKLQLEKVTAE----------------AKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAE 1010
Query: 786 QNDQVS-FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEE 844
+ Q++ + L K+ ++++ I +EE L+ E EK + L E L+++
Sbjct: 1011 CSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 845 IGNVQLEKAQ-QLSITSKVQELQN-LLKGKEEQM---NTMKAVLE------------EKE 887
I +Q + + +L + K +ELQ L +G +E + N +K V E E E
Sbjct: 1071 IAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESE 1130
Query: 888 KDLANTG-KWLQDLQEENESLKAHVQEVAQHNLKEASSASQFE-ELEIVLKEKENELKRL 945
K N K +DL EE E+LK +++ + ++ E E+ + K E E K
Sbjct: 1131 KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNH 1190
Query: 946 EAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQ-------------QNYQQASSFP 992
EA +++ ++ + L + ++ K FK+ +E+ KQ + QQ +
Sbjct: 1191 EAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES 1250
Query: 993 PH---------EELLKVISEREK-------EISGLWNELDSLKDAVEHQRKKNNDLREKN 1036
H +EL +SE ++ + S L NELD++ +E KK +
Sbjct: 1251 EHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 1037 WEAMEALASTEKMLQD----KVNKTSKERQ--------QQVEAVELEAKEVLKKLF---- 1080
L T+++LQ+ K+N +S+ RQ Q+ + E EA++ L+K
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 1081 -----PKVSVPSNLSYGEWLHGFEKK-AKECMAGTSGSEEVKVLEHKLKEAD-------- 1126
K V +L E L +KK K+ A + EE + KL++
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 1127 ----------EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIK 1176
++ + L+ + +K+ +LAE + I + ++ E + + K ++ +
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 1177 QMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
++ + + E+ + + D+E+L ++ + + + E + +V E++ L E
Sbjct: 1491 ALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEE 1550
Query: 1237 LQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQK--VAGDLHKAQQSL--EL 1292
L+ +L + +R + +KAQ L + R EQNE +K + + + + L E
Sbjct: 1551 LEDELQATEDAKLRLEVNMQAMKAQFERDL-QTRDEQNEEKKRLLIKQVRELEAELEDER 1609
Query: 1293 IQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
Q + A+ I+ D+ + E++ K + ++ + QL++ LQA + +E E
Sbjct: 1610 KQRALAVASKKKMEIDLKDLEAQIEAANK-----ARDEVIKQLRK-LQAQMKDYQRELE 1662
Score = 97.1 bits (240), Expect = 1e-19
Identities = 123/554 (22%), Positives = 250/554 (45%), Gaps = 51/554 (9%)
Query: 821 LLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMK 880
LL+V +E+ +Q +E+ +KE+ V+ E + ++ E +N+L EQ+
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILA---EQLQAET 900
Query: 881 AVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL----KEASSASQFEELEIVLK 936
+ E E+ A Q+L+E L++ V+E + N ++ + ++LE L
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 937 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE 996
E+E ++L+ E+ + + + ++D+N F + ++L + + SS EE
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE-KKLMEDRIAECSSQLAEEE 1019
Query: 997 LLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNK 1056
E+ K ++ + N+ + + +E + KK R++ +A L LQD++
Sbjct: 1020 ------EKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI-- 1071
Query: 1057 TSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE--KKAKECMAGTSG-SE 1113
E Q Q++ ++L+ + ++L ++ + E LH K +E A + E
Sbjct: 1072 --AELQAQIDELKLQLAKKEEELQGALARGDD----ETLHKNNALKVVRELQAQIAELQE 1125
Query: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAET---EGILQKLQRSVEQEENKWKVKVDE 1170
+ + + +A++ L E E K+ L +T Q+L+ EQE + K ++E
Sbjct: 1126 DFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE 1185
Query: 1171 SHKT----IKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTE 1226
K I+ M+ ++ +EL ++ +E +R + +LE + E + E
Sbjct: 1186 ETKNHEAQIQDMRQRHATALEEL------SEQLEQAKRFKANLEKNKQGLETDNKELACE 1239
Query: 1227 VRELKDLLTELQ---KKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL 1283
V+ L+ + E + KKLD E + E + L+ +L E +KL QNE V+ L
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL---QNELDNVSTLL 1296
Query: 1284 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1343
+A++ K +K A D +E+ + E+ ++L+ + QL++ ++
Sbjct: 1297 EEAEK-------KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQ 1349
Query: 1344 QQLTKEKEHYQVLE 1357
+Q +E+E + LE
Sbjct: 1350 EQQEEEEEARKNLE 1363
Score = 67.4 bits (163), Expect = 9e-11
Identities = 118/678 (17%), Positives = 259/678 (38%), Gaps = 74/678 (10%)
Query: 45 QKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNV 104
Q+L+ +T +K + ++ E + +L E E L + Q+A V
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Query: 105 VE---TSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAAS 161
+ T S+ E KKK K L +++ +++ A + + TK +
Sbjct: 1381 DDDLGTIESLEEAKKKLLKDAEALSQRLEEKALA-------YDKLEKTKNRLQQELDDLT 1433
Query: 162 KKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENV 221
Q++ + + + KK + L+ K A + + E A +++++T+ +
Sbjct: 1434 VDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE-------AEAREKETKAL 1486
Query: 222 FVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAE 281
+ L A + + D +++ K D + + + K E E
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSS-KDDVGKNVHELEKSKRALEQQVEEMR 1545
Query: 282 VKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLL 341
+ ++ EDE D K + V A+K + +L T Q +EK +LL
Sbjct: 1546 TQLEEL----------EDELQATEDA-KLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLL 1594
Query: 342 -AAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE 400
V+E A +D KQ + K++ + + ++ +I K + ++ +
Sbjct: 1595 IKQVRELEAELEDERKQRAL-AVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQ 1653
Query: 401 TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK--LRQDYARL 458
+ Q + ++ R + A K+ L+ + E S+E + Q+ L
Sbjct: 1654 MKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDEL 1713
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDL 518
+E+T +K+ E QL+ +L+E + E + RK T
Sbjct: 1714 ADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL--------- 1764
Query: 519 QSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN 578
+V +L+++L +E+ K ++ + Q++ QN
Sbjct: 1765 ---------QVDTLNAELA------------------AERSAAQKSDNARQQLE---RQN 1794
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+ LKA++Q+ + ++ A++ A L I + ++Q++Q A+ + E++LK
Sbjct: 1795 KELKAKLQELEGAVKSKFKATISA--LEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLK 1852
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
+I + + + + A +L++ + + + +LQ E+ + E
Sbjct: 1853 EIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATE 1912
Query: 699 EFKILNDQNKALKSEVQK 716
+ L+ + LK+ +++
Sbjct: 1913 ANEGLSREVSTLKNRLRR 1930
Score = 55.8 bits (133), Expect = 3e-07
Identities = 47/234 (20%), Positives = 114/234 (48%), Gaps = 14/234 (5%)
Query: 1132 LQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELER 1191
L+L ++ V + + +LQ V ++E + + K DE +K+ Q+ +E+ER
Sbjct: 827 LKLRHWQWWRVFTKVKPLLQ-----VTRQEEELQAK-DEELLKVKEKQTKVEGELEEMER 880
Query: 1192 LRSENKDIENLRREREHLEMEL-EKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVR 1250
+ + +N+ E+ E EL +AE R+ + +EL+++L +L+ ++++
Sbjct: 881 KHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940
Query: 1251 QNEELNLLKAQLNETLTKLRTEQNERQKVA-------GDLHKAQQSLELIQSKIVKAAGD 1303
E ++A + + +L E+ RQK+ + K ++ + L++ + K +
Sbjct: 941 LQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKE 1000
Query: 1304 TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
++E+ ++ +E+E + +L + + + ++ + ++L KE++ Q LE
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELE 1054
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 167 bits (424), Expect = 5e-41
Identities = 295/1408 (20%), Positives = 588/1408 (41%), Gaps = 225/1408 (15%)
Query: 74 ESDSESVPRD---FKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI 130
ESD E V D K + L + + ET S +E+ +K L+EQ+
Sbjct: 265 ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLD 324
Query: 131 KE-SDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSK 189
+ + KI K + TK T +A ++ Q K ++ + + ETL + K
Sbjct: 325 ERLQELEKI--KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEM--K 380
Query: 190 RQEALPLHQETKQESGSGKK-----------------KASSKKQKTENVF------VDEP 226
+E L KQ + G++ KA S QKTE +DE
Sbjct: 381 EEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQ 440
Query: 227 L--IHATTYIPLMDNADSSPVVDKREVIDLLKP---DQVEGIQKSGTKKL--KTETDKEN 279
+ I T+ + V K+EV+D++K +Q+ +QK K+L K + +
Sbjct: 441 IKTIEKTSEEERISLQQELSRV-KQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKK 499
Query: 280 AEVKFKDFLLSLKTMMF-SEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKD 338
+ + ++F +K + S+ E L + +++ + + L+ K LT ++L++
Sbjct: 500 LQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQ 559
Query: 339 K-----------LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM----KDRIGTL 383
+ L +++++ K++ K L + EK + N IT M K + +L
Sbjct: 560 QEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESL 619
Query: 384 EKEHN-VFQNKIHVSYQETQQMQMKFQQVREQMEAEI------------AHLKQENGILR 430
+ + + ++ K+ V QQ Q + +++RE+ E E AH+++ N
Sbjct: 620 KHQQDALWTEKLQVL---KQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTL 676
Query: 431 DAVSNTTNQLESKQS--AELNKLRQDYARLVNELTEKTGKLQQE-----EVQKKNAEQAA 483
+ + +LES S +E+ K R ++ L ++T K++QE + QK + +Q
Sbjct: 677 EKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQV 736
Query: 484 TQL----KVQLQEAERRWEEVQSYIR-------KRTAEHEAAQQDLQSKFVAKENEVQSL 532
+ +V +Q E+ ++ + + K EH+A ++L++ E E+Q
Sbjct: 737 DSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQA 796
Query: 533 HSKLT-----------DTLVSKQQLEQRLMQLMESEQKRV---NKEESLQMQVQDILEQN 578
+KL T ++QL Q +L++ E +R+ + ++ Q +D+ +
Sbjct: 797 SAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELK 638
+A K Q+Q Q+ Q S E ++++K S+ + ++E+ K
Sbjct: 857 DAHKIQVQDLMQQLEKQNS-------------EMEQKVKSLTQVYESKLEDGNKEQEQTK 903
Query: 639 DIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKME 698
I V+K + + E+E + Q + K+D I +L E+ + + N
Sbjct: 904 QIL---------VEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN--- 951
Query: 699 EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
Q K ++ QK K++ E ++K + +++ KLK + LE +++
Sbjct: 952 -------QEKKMEKVKQKA---------KEMQETLKKKLLDQEAKLK---KELENTALEL 992
Query: 759 ATKEEELNAIRTE-----NSSLTKEVQDLKAKQNDQVSFASLVE--ELKKVIHEKDGKI- 810
+ KE++ NA E ++ ++ V L+ Q +Q+ + V EL VI + K+
Sbjct: 993 SQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLN 1052
Query: 811 KSVEELLEAELLKVANKEKTVQDLKQEIKAL---KEEIGN-VQLEKAQQLSITSKVQELQ 866
+ EEL E +++ KE+ V +LKQ+I KEE+ + K + + + + ELQ
Sbjct: 1053 QQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 867 NLLKGKEEQMNTM-------KAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNL 919
LK K +N++ KA LE+ E DL + K LQE+ LK +E
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEE------ 1166
Query: 920 KEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ 979
+ EL LK + E + L++ ++ L K+ + + +E + + I
Sbjct: 1167 ----DKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAI-QLDICC 1221
Query: 980 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1039
K + +A + EL+ + S + I L + K L K
Sbjct: 1222 KKTEALLEAKT----NELINISSSKTNAI------LSRISHCQHRTTKVKEALLIKTCTV 1271
Query: 1040 MEALASTEKMLQDK--VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHG 1097
E A ++ +++ +N + ++ Q+E E + K + K + S ++
Sbjct: 1272 SELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSM------KADIESLVT------- 1318
Query: 1098 FEKKAKECMAGT---SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ 1154
EK+A + G + SE+ + KE E + L E+ K E + ++L
Sbjct: 1319 -EKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLT 1377
Query: 1155 RSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQEL-ERLRSENKDIENLRRER----EHL 1209
Q +N + + E I ++ + + EL ++++ + ++ L +E+ E +
Sbjct: 1378 DLNVQLQNS--ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 1210 EMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKL 1269
+ K + + + ++ + ELQ +L+ EA ++E++NLLK +L++ +
Sbjct: 1436 DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRF 1495
Query: 1270 RTEQNERQKVAGDLHKAQQSLEL-IQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSL 1328
+ E + + K + +LE ++S+ + + E ++K SL
Sbjct: 1496 DCLKGEMEDDKSKMEKKESNLETELKSQTARI-----------MELEDHITQKTIEIESL 1544
Query: 1329 NQTVTQLQQLLQAVNQQLTKEKEHYQVL 1356
N+ + Q +++L ++ +H+Q L
Sbjct: 1545 NEVLKNYNQQKDIEHKELVQKLQHFQEL 1572
Score = 159 bits (401), Expect = 2e-38
Identities = 285/1429 (19%), Positives = 583/1429 (40%), Gaps = 190/1429 (13%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSD 88
+ L + + A+ K E++L K K +++ K + Q N H+ +S+ ++ ++S
Sbjct: 689 LSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK-NHHQQQVDSIIKEHEVS- 746
Query: 89 ALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
++ +N +E R++ KE + E IK S+ V
Sbjct: 747 --IQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
Query: 149 TKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGK 208
+ Q + A +++ Q + K D + E +++ + E ++ E + K
Sbjct: 805 SYQSATHEQTKAYEEQLAQLQQKL----LDLETERILLTKQVAEVEAQKKDVCTELDAHK 860
Query: 209 KKASSKKQKTENVFVD-EPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSG 267
+ Q+ E + E + + T + D + ++ + I + K + + +++
Sbjct: 861 IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQ 920
Query: 268 TKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSS---- 323
K+++ T K +A+ L F E ++ +K+K+ +Q+ LKK
Sbjct: 921 KKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKK--MEKVKQKAKEMQETLKKKLLDQE 978
Query: 324 ---KGELTTLIHQLQEKDK-----LLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITR 375
K EL +L +K+K +L + ++A D +L + E V R
Sbjct: 979 AKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRR 1038
Query: 376 -MKDRIGTLEKEHN--------VFQNKIHVSYQETQQMQMK---FQQVREQMEAEIAHLK 423
+ D I EK+ N + + ++ QE +++ K F +E+M EI LK
Sbjct: 1039 ELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLK 1098
Query: 424 QENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA 483
+E G+ +D N + ++SA +N L QD +L L + L + + ++
Sbjct: 1099 EE-GVKQDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL 1157
Query: 484 TQLKVQLQEAERRWEEVQSYIRKRTAE-------HEAAQQDLQSKFV------------- 523
+LK+ +E +R+ E+ S ++ E HE + + L+ K +
Sbjct: 1158 VELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQL 1217
Query: 524 ------------AKENEVQSLHSKLTDTLVSK-QQLEQRLMQLMESEQKRVNKEESLQMQ 570
AK NE+ ++ S T+ ++S+ + R ++ E+ + L+ Q
Sbjct: 1218 DICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQ 1277
Query: 571 VQDILEQNEALKAQIQQFHSQIAA-QTSASVLAEELHKVIAEKDKQIKQ--TEDSLASER 627
++ + E+ L QQ Q+ + + ++ ++ EK+ K+ + ASE+
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 628 DR-LTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE-KMQQSVYV--KDDKIR 683
+ +T ++EL + N L+K E+++ + + + +L ++Q S+ + K+ I
Sbjct: 1338 ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAIS 1397
Query: 684 LLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEK 743
L +Q E +++ + L+ + L E V + NK E +K +
Sbjct: 1398 SLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNK-FSEWKKKAQSRFTQH 1456
Query: 744 LKTVEEL---LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE-L 799
TV+EL LE + K+E++N ++ E K LK + D S E L
Sbjct: 1457 QNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNL 1516
Query: 800 KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSIT 859
+ + + +I +E+ + + +++ + + +++ Q+ +E+ +L+ Q+L
Sbjct: 1517 ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQ-KLQHFQELGEE 1575
Query: 860 --SKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH 917
++V+E + + E Q+ +MKA LE K+K+L + ++ +EE ++L+ ++ +
Sbjct: 1576 KDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAA 1635
Query: 918 NLKEASSA-------------SQFEELEIVLKE-KENELKRLEAMLKERESD---LSSKT 960
L E SQ EE E K+ E+ L L L+ERE + L K
Sbjct: 1636 KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKL 1695
Query: 961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFP-----PHEELLKVI----SEREKEISGL 1011
+ ++ Q E + + + Q+ + +EE + V+ +E+EK + +
Sbjct: 1696 KSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRV 1755
Query: 1012 WNELDSLKDA--------------VEHQRKKNND-----------LREKNWEA------- 1039
E + + +EH K ++ L EKN +
Sbjct: 1756 GQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQH 1815
Query: 1040 ---------MEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
++A + E + D V KT +E++ + +E + KE+ L + V +
Sbjct: 1816 VEKEGGKNNIQAKQNLENVFDD-VQKTLQEKELTCQILEQKIKELDSCLVRQKEV-HRVE 1873
Query: 1091 YGEWLHGFEK-KAKECMAGTSGSEEVKVLEHKLKEADEMHTL-------LQLECEKYKSV 1142
E +EK +A + M G + E+ LE +E + H + ++ + +
Sbjct: 1874 MEELTSKYEKLQALQQMDGRNKPTEL--LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
Query: 1143 LAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSS-------EQELERLRSE 1195
LA E QKL + + + + ++ E + ++ ++ + EQE L+
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELK-H 1990
Query: 1196 NKDIENLRRE--------REHLEMELEKA-----EMERSTYVTEVRELKDLLTELQKKLD 1242
N ++ L RE + LEM +++ E+E + E LL ++ +K D
Sbjct: 1991 NSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 1243 DSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLE 1291
D A R E L+ + ++ + L+T+ E QK K QQ LE
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQK------KYQQKLE 2093
Score = 155 bits (392), Expect = 2e-37
Identities = 278/1331 (20%), Positives = 569/1331 (42%), Gaps = 163/1331 (12%)
Query: 51 KTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSS 110
K +KK EK K K KE+Q E++ + DQ A + + T+
Sbjct: 950 KNQEKKMEKVKQKAKEMQ---------ETLKKKLL---------DQEAKLKKELENTALE 991
Query: 111 VRERKKK-EKKQKPVLEEQVIKESDA-SKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQK 168
+ +++K+ K + + SDA S++ + E + + T + +
Sbjct: 992 LSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI---ESLTEVHRRELNDVISIWE 1048
Query: 169 KSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLI 228
K N ++ +++ + + K QE L Q+ G +K K+ T +E +
Sbjct: 1049 KKLNQQAEELQEIHEIQLQEKEQEVAELKQKILL---FGCEKEEMNKEIT--WLKEEGVK 1103
Query: 229 HATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKF-KDF 287
TT L + + K ++ L D+ + K+ +KL+ + +K E F ++
Sbjct: 1104 QDTTLNELQEQ-----LKQKSAHVNSLAQDETK--LKAHLEKLEVDLNKSLKENTFLQEQ 1156
Query: 288 LLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKED 347
L+ LK M +E++ V +L + ++ S E + L++K + E+
Sbjct: 1157 LVELK--MLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSN--KSLEDKSLEFKKLSEE 1212
Query: 348 AAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQET---QQM 404
A D C + T+ ++ K + I+ K + + H ++ T + +
Sbjct: 1213 LAIQLDICCKKTEALLEAKTNELINISS--------SKTNAILSRISHCQHRTTKVKEAL 1264
Query: 405 QMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLV--NEL 462
+K V E +EA++ L +E L + T+QLE K++ ++ ++ D LV E
Sbjct: 1265 LIKTCTVSE-LEAQLRQLTEEQNTLNISFQQATHQLEEKEN-QIKSMKADIESLVTEKEA 1322
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
+K G QQ+ +K E TQLK +L E ++ ++++ E + + L
Sbjct: 1323 LQKEGGNQQQAASEK--ESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLN 1380
Query: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQ----- 577
V +N + SL K ++Q ++ +L++ Q K ++L + LEQ
Sbjct: 1381 VQLQNSI-SLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWS 1439
Query: 578 ---NEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
+E K +F + E K EKD+QI ++ L + R +
Sbjct: 1440 NKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLK 1499
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEIS 694
E++D ++ ++ + L+ Q A ELE + K +I L E L++
Sbjct: 1500 GEMEDDKSK---MEKKESNLETELKSQTARIMELE---DHITQKTIEIESLNEVLKNYNQ 1553
Query: 695 NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK-----DVVEQMEKCIQEKDEKLKTVEE 749
K + ++K L ++Q Q L E+ N+ + + +E + +L+T ++
Sbjct: 1554 QK-------DIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKK 1606
Query: 750 LLETGLIQVATKEEELNAI--RTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKD 807
LE + V +KEEEL A+ R E+ S K + +LK K ++ A++ ++L + EK+
Sbjct: 1607 ELEHVNLSVKSKEEELKALEDRLESESAAK-LAELKRKAEQKI--AAIKKQLLSQMEEKE 1663
Query: 808 GKIKSVEELLEAEL-LKVANKEKTVQDLKQEIKALKEEIGNVQL--EKAQQLSITSKVQE 864
+ K E +EL K+ +E+ V L++++K+++ + A+ ++ ++ +E
Sbjct: 1664 EQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEE 1723
Query: 865 LQN---LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLK- 920
+ + K EE+++ ++ L EKEK L G QE+ E++ +H + Q+ +
Sbjct: 1724 ADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVG------QEKEETVSSHFEMRCQYQERL 1777
Query: 921 ---EASSASQFEELEIV------LKEKENELKRLEAMLKERE---SDLSSKTQL---LQD 965
E + A Q E+ ++ L+EK + + A E+E +++ +K L D
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837
Query: 966 VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
VQ + + + L+Q+ + S +E+ +V E E++ + +L +L+
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEME---ELTSKYEKLQALQQM--DG 1892
Query: 1026 RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSV 1085
R K +L E+N E S ++Q K+ + + +E A+ +KL
Sbjct: 1893 RNKPTELLEENTEE----KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKL------ 1942
Query: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKL-KEADEMHTLLQLECE-KYKSVL 1143
G+ + +K + M +E+++L+ + +E +E Q + E K+ S L
Sbjct: 1943 ------GKEIVRLQKDLR--MLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTL 1994
Query: 1144 AETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQE-----LERLRSENKD 1198
+ ++++ + Q+E + ++ + E+ +++++ S QE L+++ ++ D
Sbjct: 1995 KQ---LMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDD 2051
Query: 1199 IENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAV---RQNEEL 1255
++ + E + ++ + EM +VR+L+ L ELQKK + N +
Sbjct: 2052 LKRTAKRYEEI-LDAREEEM-----TAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTI 2105
Query: 1256 NLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV----IENSD 1311
L+ QL + T + + + Q+ +H + L+ + + T + ++D
Sbjct: 2106 MELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKGGNLYHTD 2165
Query: 1312 VSPETESSEKE 1322
VS E +E E
Sbjct: 2166 VSLFGEPTEFE 2176
Score = 113 bits (283), Expect = 1e-24
Identities = 167/845 (19%), Positives = 374/845 (44%), Gaps = 137/845 (16%)
Query: 621 DSLASERDRLTSKEEELKDIQNMN-----------------FLLKAEVQKLQA-LANEQA 662
+ L D L +KE+ ++ ++ M +L+ E +KLQ L+ Q
Sbjct: 125 EDLVGNSDSL-NKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQD 183
Query: 663 AAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKS-------EVQ 715
+ + ++++ + + + L+E+ + K + +L Q LK V
Sbjct: 184 KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD 243
Query: 716 KLQTLVSEQPNKDVVEQME----------------KCIQEKDEKLKTVEELLETGLIQVA 759
L+ L +P +V + E K ++ +++K E LL+ +
Sbjct: 244 VLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQ 303
Query: 760 TKEEELNAIRTENSSLTKE----------VQDL----KAKQNDQVSFA-SLVEELKK--- 801
+ +E+ + +E +L ++ ++DL K K Q+ A +L+E+L++
Sbjct: 304 SHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKG 363
Query: 802 -VIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ-LSIT 859
VI E ++ E+ E E+ ++ ++ K + +E++ KE+ E+ ++ LS
Sbjct: 364 MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423
Query: 860 SKVQELQNLLKGK-EEQMNTMKAVLEEK----EKDLANTGKWLQDLQEENES------LK 908
K +E + LK + +EQ+ T++ EE+ +++L+ + + D+ +++ K
Sbjct: 424 QKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK 483
Query: 909 AHVQEVA-----------------QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKE 951
H +E+A Q +K A SQ E L+I ++++ E LE + +
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543
Query: 952 RESDLSSKTQLLQDVQDENKLFKSQIEQLK-------QQNYQQASSFPPHEELLKVISER 1004
+++ L+ L+D+Q E + ++++I +L+ Q+N Q+ H E K ++
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEK--NKH 601
Query: 1005 EKEISGLWNELDSLKDAVEHQR-----KKNNDLREKNWEAMEALASTEKMLQDKVNKTSK 1059
KEI+ + + + ++++HQ+ +K L+++ ME L EK Q+K K
Sbjct: 602 NKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKL--REKCEQEK-ETLLK 658
Query: 1060 ERQQQVEA-VELEAKEVLKKLFPKVSVPSNLS--YGEWLHGFEKKAKECMAGTSGSEEVK 1116
+++ +A +E ++ L+KL K + +LS E L K +E ++++K
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 1117 -VLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTI 1175
LE K+ E H ++ S++ E E +Q+ +++++ + N+ ++ + E K +
Sbjct: 719 QELEAKMDEQKNHHQ------QQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL 772
Query: 1176 KQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLT 1235
K+ Q+ + E +++R E + +L+ + +S + + ++ L
Sbjct: 773 KEHQAHVENLEADIKRSEG----------ELQQASAKLDVFQSYQSATHEQTKAYEEQLA 822
Query: 1236 ELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1295
+LQ+KL D +E + +++ ++AQ + T+L + + Q + L K +E
Sbjct: 823 QLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME---- 878
Query: 1296 KIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQ----LLQAVNQQLTKEKE 1351
K T V E+ E + + + V + Q+++ ++ + Q+L+ +++
Sbjct: 879 --QKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936
Query: 1352 HYQVL 1356
+L
Sbjct: 937 SIHIL 941
Score = 35.4 bits (80), Expect = 0.37
Identities = 66/324 (20%), Positives = 137/324 (42%), Gaps = 44/324 (13%)
Query: 1046 TEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKEC 1105
TE++ + N+ S + Q + ++L V + LF + + +L F +KE
Sbjct: 43 TEQLDEGTPNRESGDTQSFAQKLQLRVPSV-ESLF-RSPIKESL--------FRSSSKES 92
Query: 1106 MAGTSGSEEVKVLEHKLKEAD-EMHTLLQLECEKY--KSVLAETEGILQKLQRSVEQEEN 1162
+ TS E + L+ A + + + E E S E ++Q+L+R +E+ +
Sbjct: 93 LVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRR-MERSLS 151
Query: 1163 KWKVKVDESHKTIKQMQSS--------FTSSEQELERLRSENKDIENLRREREHLEMELE 1214
++ K E + +Q S ++ L R+ ++++ ++ ++HL+ E +
Sbjct: 152 SYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEEFD 211
Query: 1215 KAEMERSTYV----TEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR 1270
+ E+ Y+ T+V LK L +D + L L+ Q E TK
Sbjct: 212 ASLEEKDQYISVLQTQVSLLKQRLRNGPMNVD--------VLKPLPQLEPQA-EVFTKEE 262
Query: 1271 TEQNERQKVAGD------LHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM 1324
+++ + V D L QQ ++ Q ++K +T I++ +SEKE +
Sbjct: 263 NPESDGEPVVEDGTSVKTLETLQQRVKR-QENLLKRCKET--IQSHKEQCTLLTSEKEAL 319
Query: 1325 SVSLNQTVTQLQQLLQAVNQQLTK 1348
L++ + +L+++ + TK
Sbjct: 320 QEQLDERLQELEKIKDLHMAEKTK 343
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 166 bits (421), Expect = 1e-40
Identities = 292/1408 (20%), Positives = 581/1408 (41%), Gaps = 200/1408 (14%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNL-----HESDSESVPRDFK---LS 87
E L KQ + +K + KK ++KN EI G L H S + P K L
Sbjct: 354 EWLEKQAQLEKELSAALQDKKCLEEKN---EILQGKLSQLEEHLSQLQDNPPQEKGEVLG 410
Query: 88 DALAVED--DQVAPVPLNVVETSSSVR----ERKKKEKKQKPVLEEQVIKESDASKIPGK 141
D L +E + A + N + + V ER ++E K +L E+ E + ++
Sbjct: 411 DVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAK---LLAERGHFEEEKQQLSSL 467
Query: 142 KVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLH---Q 198
+T + S + +K++ Q +G+ T V S E L+ Q
Sbjct: 468 ------ITDLQSSISNLSQAKEELEQASQAHGAR------LTAQVASLTSELTTLNATIQ 515
Query: 199 ETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPD 258
+ QE K++A K+ + + A+ + SS + K + + +
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQE--QASQGLRHQVEQLSSSLKQKEQQLKEVAEK 573
Query: 259 QVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDA 318
Q E ++ ++L T ++ A ++ +D +LK + E E +++L+++ V +A
Sbjct: 574 Q-EATRQDHAQQLATAAEEREASLRERD--AALKQLEALEKEKAAKLEILQQQLQVANEA 630
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKD 378
+ T + Q Q + L+ E+ A + +Q E +
Sbjct: 631 -----RDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ------------- 672
Query: 379 RIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTN 438
+ LE + Q K E +++ + Q++EQ++A LK G L + +
Sbjct: 673 -VAELELQLRSEQQKA----TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAAD 727
Query: 439 QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE 498
LE +Q +++L+ + LV + + +L++E +K E QL EA +
Sbjct: 728 ALEEQQRC-ISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLG----EAHQAET 782
Query: 499 EVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQ 558
EV +R+ AE AAQ +S+ EV + + D+ Q E+ M EQ
Sbjct: 783 EV---LRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDS-----QQEEAQYGAMFQEQ 834
Query: 559 KRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQ 618
KEE + + Q++ E E + A I+ HS++ + LAE LH +A +Q+++
Sbjct: 835 LMTLKEECEKAR-QELQEAKEKV-AGIES-HSELQISRQQNELAE-LHANLARALQQVQE 890
Query: 619 TEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVK 678
E D L++ +E++ L+ V+K +Q A+ EL K +
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKA---GEQQETASRELVK--EPARAG 945
Query: 679 DDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ 738
D + LEEQ + + + + + + + +E+++L+ + E + +Q E+ Q
Sbjct: 946 DRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQ---QQEERGQQ 1002
Query: 739 EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEE 798
E++ T E + +L + + L +Q+ A +V FA+L E
Sbjct: 1003 EREVARLTQER---------GRAQADLALEKAARAELEMRLQN--ALNEQRVEFATLQEA 1051
Query: 799 LKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQL-- 856
L + EK+GK + + +L E ++ K +++L+Q +K LKE++ + E A
Sbjct: 1052 LAHALTEKEGKDQELAKLRGLEAAQI----KELEELRQTVKQLKEQLAKKEKEHASGSGA 1107
Query: 857 ----------------SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL 900
++ ++V +L+ + ++EQ ++++ LE + A L+ L
Sbjct: 1108 QSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETL 1167
Query: 901 QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKT 960
Q + L+ QE+ AS+ + +++ +A + + K
Sbjct: 1168 QGQ---LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKN 1224
Query: 961 QLLQDVQDENKLFKSQI-------EQLKQQNYQQASSFPPHEELLKVI--------SERE 1005
L+ +++E + Q+ ++LK+ ++ EE L+++ +
Sbjct: 1225 SLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREK---NWEAMEALASTEKMLQDKVNKTSKERQ 1062
+ S L E+ SL++ E QR + +LR++ E E L K Q+K +++
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFF----QKE 1340
Query: 1063 QQVEAVELE---AKEVLKKLFPKVSVPSNL----SYGEWLHGFEKKAKECMAGTSGSEEV 1115
Q + ++LE + ++ +L P + L + E H E + + AG +E +
Sbjct: 1341 QALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Query: 1116 K-------VLEHKLKEADEMHTLLQLECEKYK-----SVLAETEGILQKLQRSVEQEENK 1163
+ ++ + K A++ T QL EK S+L + G+L + R + + N
Sbjct: 1401 RAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 1164 WK----VKVDESHKT---------------IKQMQSSFTSSEQELERLRSENKDIE-NLR 1203
+ V++D++ + + ++Q S+ +ELE + ++ + + +
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 1204 REREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLN 1263
ER+ + E +K + RE + EL KKL DS + Q ++L ++AQ
Sbjct: 1521 EERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGG 1580
Query: 1264 ETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
E+ + + Q + ++ L + +Q+ E + ++ KA +T K+
Sbjct: 1581 ESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKA--------------KTHYDAKKQ 1626
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
+ L + + L+Q LQ N++L E E
Sbjct: 1627 QNQELQEQLRSLEQ-LQKENKELRAEAE 1653
Score = 155 bits (393), Expect = 2e-37
Identities = 311/1466 (21%), Positives = 577/1466 (39%), Gaps = 256/1466 (17%)
Query: 88 DALAVEDD-----QVAPVPLNVVET-SSSVRERKKKEKKQKPVLEEQVIKESDASK--IP 139
D L + +D Q APVP T + + K++ LE Q + S + +
Sbjct: 139 DGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNNFLS 198
Query: 140 GKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQE 199
G P+ Q TP + KK+ ++S + + ++ K + + Q
Sbjct: 199 GSPASPMGDILQ-TPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQR 257
Query: 200 TKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQ 259
+ + +K+A+S + E L + D + + R + + LK Q
Sbjct: 258 IDRLALLNEKQAASPLEPKE----------------LEELRDKNESLTMR-LHETLKQCQ 300
Query: 260 VEGIQKSGTKKLKTETDKENAEVKFK--DFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
+KS + + +EN ++ FK +F L+ + + +E L +E S Q+
Sbjct: 301 DLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNE------LTEEHSKATQE 354
Query: 318 ALKKSSK--GELTTLIHQ---LQEKDKLL----AAVKEDAAATKDRCKQLTQEMMTEKER 368
L+K ++ EL+ + L+EK+++L + ++E + +D Q E++ +
Sbjct: 355 WLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDV-- 412
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
+ + +K TL + Q ++ + E Q + K R E E L
Sbjct: 413 --LQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITD 470
Query: 429 LRDAVSNTTN---QLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQ 485
L+ ++SN + +LE A +L A L +ELT +QQ++ + +Q A +
Sbjct: 471 LQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKE 530
Query: 486 LKVQLQEAERRWEEVQSYIRKRTAEHEAA--QQDLQSKFVAKENE------VQSLHSKLT 537
+ QL + ++ E+ +R + + ++ Q++ Q K VA++ E Q L +
Sbjct: 531 KQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE 590
Query: 538 DTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTS 597
+ S ++ + L QL E+++ K E LQ Q+Q E ++ + + Q + A+ S
Sbjct: 591 EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE-KAELS 649
Query: 598 ASVLAEELHKVIA-------EKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE 650
V EEL + E Q+ + E L SE+ + T KE ++ + L+A
Sbjct: 650 RKV--EELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 651 VQKLQ----ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
+ L+ +L E+ AA LE+ Q+ + + R L EQ + E EE
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEE----RAG 763
Query: 707 NKALKSEVQKL---QTLVSEQPNKDVVEQM----------EKCIQEKDEKLKTVEELLET 753
K L++ +Q+L +E +++ E M E+ ++E + E+ +
Sbjct: 764 RKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQE 823
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
A +E+L ++ E +E+Q+ K K A + + I + ++ +
Sbjct: 824 EAQYGAMFQEQLMTLKEECEKARQELQEAKEK------VAGIESHSELQISRQQNELAEL 877
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQN------ 867
L L +V KE Q L ++ L+E++ E A+ ++ K E Q
Sbjct: 878 HANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937
Query: 868 --------------LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL-----------QE 902
L + + Q + +A L+ E++ G L+ L QE
Sbjct: 938 VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE 997
Query: 903 ENESLKAHVQEVAQHN--------LKEASSASQFEELEIVLKEKENELKRLEAMLKERES 954
E + V + Q L++A+ A L+ L E+ E L+ L +
Sbjct: 998 ERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALT 1057
Query: 955 DLSSKTQLL-----------QDVQDENKLFKSQIEQLKQQNYQQAS-------------- 989
+ K Q L +++++ + K EQL ++ + AS
Sbjct: 1058 EKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP 1117
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKK-----------NNDLREKNWE 1038
+ P E L +S+ E++ + DSL+ ++E +R L EK E
Sbjct: 1118 TGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQE 1177
Query: 1039 ---AMEALASTEKML---QDKVNKTSK---ERQQQVEAVELEAK---EVLKKLFPKVSVP 1086
+ ALAS ++ L + KV SK E + QV EA+ ++ L +VS+
Sbjct: 1178 LGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSIL 1237
Query: 1087 SNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET 1146
+ + G K+ K + + SE+ + LE +L+ LLQ E + AE
Sbjct: 1238 NRQVLEK--EGESKELKRLV--MAESEKSQKLEERLR-------LLQAETASNSARAAER 1286
Query: 1147 EGILQKLQRSVEQEENKWKV--------------KVDESHKTIKQMQSSFTSSEQELERL 1192
L++ +S+ +E K +V + +E + +K Q F EQ L L
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
Query: 1193 RSENKDIENL----------------------RREREHLEMELEKAEMERSTYVTEVREL 1230
+ E+ + L +R RE LE + A R+ + REL
Sbjct: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL 1406
Query: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR------TEQNERQKVAGDLH 1284
+L+ QK +E R ++L KA E L+ L+ E+N +L
Sbjct: 1407 GELIPLRQK-----VAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLG 1461
Query: 1285 KAQQSLELIQSK--------IVKAAGDTTVIENSDVSPETESSEKETMSVSLNQ-----T 1331
+ +EL Q++ V+A +T + E V E +S+ +E ++
Sbjct: 1462 RQFLEVELDQAREKYVQELAAVRADAETRLAE---VQREAQSTARELEVMTAKYEGAKVK 1518
Query: 1332 VTQLQQLLQAVNQQLTKEKEHYQVLE 1357
V + +Q Q Q+LT + E +V +
Sbjct: 1519 VLEERQRFQEERQKLTAQVEQLEVFQ 1544
Score = 146 bits (369), Expect = 1e-34
Identities = 257/1261 (20%), Positives = 535/1261 (42%), Gaps = 141/1261 (11%)
Query: 86 LSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEP 145
L+ + +D ++A + E + + + +++++ L QV + S + K ++++
Sbjct: 510 LNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKE 569
Query: 146 VP----VTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKR--QEALPLHQE 199
V T+Q A A++++ + ++ + Q + +E Q+ L + E
Sbjct: 570 VAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANE 629
Query: 200 TKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQ 259
+ + + +A +K + V+E + A + ++ V + E+ Q
Sbjct: 630 ARDSAQTSVTQAQREKAELSRK-VEE--LQACVETARQEQHEAQAQVAELEL-------Q 679
Query: 260 VEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFS-EDEALCVVDLLKEKSGVIQDA 318
+ Q+ T+K + +K+ + + + SLK S E+E D L+E+ I +
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISEL 739
Query: 319 LKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL-------TQEMMTEKERSNV 371
K E +L+ Q + + K L + + R +QL T+ + E +
Sbjct: 740 -----KAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMA 794
Query: 372 VITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRD 431
+ L KE ++ + S QE Q FQ+ ++ E +QE ++
Sbjct: 795 AQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKE 854
Query: 432 AVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQ 491
V+ + E + S + N+L + +A L L + +Q++EV+ + + L+ ++
Sbjct: 855 KVAGIESHSELQISRQQNELAELHANLARALQQ----VQEKEVRAQKLADDLSTLQEKMA 910
Query: 492 EAERRWEEVQSYIRKRTAEHEAAQQDLQSKFV-AKENEVQSLHSKLTDTLVSKQQLEQRL 550
+ +++ +RK + E A ++L + A + + + L + S Q
Sbjct: 911 ATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAA---- 966
Query: 551 MQLMESEQKRVNKE-ESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVI 609
+Q ME E +++ E E L+ + + Q + + Q ++ +++ + + L K
Sbjct: 967 LQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEK-- 1024
Query: 610 AEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELE 669
A + + + +++L +R + +E L E+ KL+ L +AA ELE
Sbjct: 1025 AARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGL---EAAQIKELE 1081
Query: 670 KMQQSVYVKDDKIRLLEEQ------LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE 723
+++Q+V +++ E++ Q E + + E + +AL++EV KL+ +
Sbjct: 1082 ELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEP---TGPKLEALRAEVSKLEQQCQK 1138
Query: 724 QPNKDVVEQMEKCIQ-------EKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLT 776
Q ++ + +E+ ++ E+D L+T++ LE ++ + L + + E ++
Sbjct: 1139 Q--QEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFR 1196
Query: 777 KEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQ 836
+VQD +K D+ + + V ++ K+ I S+EE + +V KE ++LK+
Sbjct: 1197 TKVQD-HSKAEDE--WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253
Query: 837 EIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 896
+ A + EK+Q+L EE++ ++A E + A +
Sbjct: 1254 LVMA--------ESEKSQKL----------------EERLRLLQA---ETASNSARAAER 1286
Query: 897 LQDLQEENESLK--AHVQEVAQHNLKE--ASSASQFEELEIVLK-------EKENELKRL 945
L+EE +SL+ A Q VA NL++ S A + EEL LK +KE L L
Sbjct: 1287 SSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTL 1346
Query: 946 EAMLKERE---SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVIS 1002
+ + S+L L Q +Q E + + + +Q+ Q A ELL+
Sbjct: 1347 QLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGL--RAELLRA-- 1402
Query: 1003 EREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM--LQDKVNKTSKE 1060
++E+ EL L+ V Q + LR + E L+ +K L + N+ E
Sbjct: 1403 --QRELG----ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGE 1456
Query: 1061 RQ---QQVEAVELE-AKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE--E 1114
R +Q VEL+ A+E + V + E + A+E T+ E +
Sbjct: 1457 RANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAK 1516
Query: 1115 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKT 1174
VKVLE + + +E L + E+ + E +++L + + + KV+ +
Sbjct: 1517 VKVLEERQRFQEERQKLTA-QVEQLEVFQREQTKQVEELSKKLADSDQASKVQ----QQK 1571
Query: 1175 IKQMQSSFTSSEQELERLRSENKDIE----NLRREREHLEMELEKAEMERSTYVTEVREL 1230
+K +Q+ S+QE +RL+++ +++ + EH ++++EKA+ + +EL
Sbjct: 1572 LKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQEL 1631
Query: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1290
++ L L+ + ++N+EL +L L + + E ++ L +SL
Sbjct: 1632 QEQLRSLE--------QLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSL 1683
Query: 1291 E 1291
E
Sbjct: 1684 E 1684
Score = 127 bits (320), Expect = 6e-29
Identities = 238/1098 (21%), Positives = 463/1098 (42%), Gaps = 135/1098 (12%)
Query: 50 TKTDKKKAEKKKNKKK-----EIQNGNLHESDSESVPRDFKL--SDALAVEDDQVAPVPL 102
T+ ++KAE + ++ E HE+ ++ + +L A E ++VA
Sbjct: 639 TQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKD 698
Query: 103 NVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
+ E +++E K K LEE+ + +DA + + + + + K
Sbjct: 699 QLQEQLQALKESLKVTKGS---LEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERK 755
Query: 163 KKPGQKKSKNGSD------DQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQ 216
+ ++ + G + + + ET ++ + EA+ + E K+ ++ ++
Sbjct: 756 ELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRE 815
Query: 217 KTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETD 276
+ E+ +E A LM + R+ + K ++V GI+ ++ + +
Sbjct: 816 RYEDSQQEEAQYGAMFQEQLMTLKEECEKA--RQELQEAK-EKVAGIESHSELQISRQQN 872
Query: 277 KENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSK--GELTTLIHQL 334
E AE+ + +L+ + E A + D L +Q+ + +SK L TL+ +
Sbjct: 873 -ELAELH-ANLARALQQVQEKEVRAQKLADDLS----TLQEKMAATSKEVARLETLVRKA 926
Query: 335 QEKDKLLAA--VKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQN 392
E+ + + VKE A A DR + +E + S + + +E+E N
Sbjct: 927 GEQQETASRELVKEPARAG-DRQPEWLEEQQGRQFCST------QAALQAMEREAEQMGN 979
Query: 393 KIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS---NTTNQLESKQSAELN 449
++ + Q + Q+ R Q E E+A L QE G + ++ +LE + LN
Sbjct: 980 ELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALN 1039
Query: 450 KLRQDYARL----VNELTEKTGKLQQ-------EEVQKKNAE---QAATQLKVQLQEAER 495
+ R ++A L + LTEK GK Q+ E Q K E Q QLK QL + E+
Sbjct: 1040 EQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEK 1099
Query: 496 RWEE---VQSYIRKRTA----------------EHEAAQQDLQSKFVAKENEVQSLHSKL 536
QS RT E + +Q Q+ + + E +
Sbjct: 1100 EHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAE 1159
Query: 537 TDTLVS--KQQLEQRLMQLMESEQKRVNKEESL---QMQVQDILEQNEALKAQIQQFHSQ 591
D+ + + QLE++ +L S+ + + L + +VQD + + KAQ+ + +
Sbjct: 1160 RDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQE 1219
Query: 592 IAAQTSA-SVLAEE---LHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
+ S S L EE L++ + EK+ + K+ + + +E ++ EE L+ LL
Sbjct: 1220 AERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLR-------LL 1272
Query: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQN 707
+AE A A E+++A L + QS+ + +K R+ E L+ E++++ E + L +
Sbjct: 1273 QAETASNSARAAERSSA---LREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQEL 1329
Query: 708 KA--------------LKSEVQKLQTLVSEQ-PNKDVVEQM-------EKCIQEKDEKLK 745
KA L+ E Q LVSE P K + +Q+ EK +E+ E+ K
Sbjct: 1330 KAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSK 1389
Query: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE 805
L L++ + EL +R + + + Q L+A++ S++++ ++ E
Sbjct: 1390 QAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAE 1449
Query: 806 KDGKIKSVEEL----LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSK 861
++ + L LE EL + +EK VQ+L + + VQ E S +
Sbjct: 1450 ENRGLGERANLGRQFLEVELDQA--REKYVQELAAVRADAETRLAEVQREAQ---STARE 1504
Query: 862 VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKE 921
++ + +G + ++ + +E+ + L + L+ Q E V+E+++ L +
Sbjct: 1505 LEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTK---QVEELSK-KLAD 1560
Query: 922 ASSASQFEELEIVLK-----EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQ 976
+ AS+ ++ ++ E + E +RL+A L E ++ LS K Q + + + + K+
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTH 1620
Query: 977 IEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELD--SLKDAVEHQRKKNNDLRE 1034
+ KQQN + E+L K E E L +EL LK Q ++ +
Sbjct: 1621 YDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQV 1680
Query: 1035 KNWEAMEALASTEKMLQD 1052
++ EA +A ++ L+D
Sbjct: 1681 RSLEAQ--VAHADQQLRD 1696
Score = 106 bits (264), Expect = 2e-22
Identities = 158/735 (21%), Positives = 318/735 (43%), Gaps = 78/735 (10%)
Query: 304 VVDLLKEKSGVIQD-ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAAT-------KD-- 353
V L +E+ D AL+K+++ EL + + ++ A ++A A KD
Sbjct: 1006 VARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQE 1065
Query: 354 --RCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQV 411
+ + L + E E + ++K+++ EKEH + T+ K + +
Sbjct: 1066 LAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEAL 1125
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
R AE++ L+Q+ ++ + LE+++++ + L +L EK +L
Sbjct: 1126 R----AEVSKLEQQCQKQQEQADSLERSLEAERASRAER-DSALETLQGQLEEKAQELGH 1180
Query: 472 EEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQS 531
+ +A++ + ++Q+ + +E ++ + + E E + S E EV
Sbjct: 1181 SQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL----EEEVSI 1236
Query: 532 LHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD----ILEQNEALKAQIQQ 587
L+ ++ + ++L++ +M E QK + LQ + E++ AL+ ++Q
Sbjct: 1237 LNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQS 1296
Query: 588 FHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLL 647
+ Q AS E L + + + ++ ++ L + +++ KE+ L +Q +
Sbjct: 1297 LREEAEKQRVAS---ENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTST 1353
Query: 648 KAEVQKL-------QALANEQAAAA----HELEKMQQSVYVKDDKIRLLEEQLQHEIS-- 694
+A V +L Q L EQAAA ELE+ +Q+ ++ + +L I
Sbjct: 1354 QALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLR 1413
Query: 695 NKMEEFKILNDQNKALK-------SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTV 747
K+ E + Q +A K S ++K L++E+ N+ + E+ Q + +L
Sbjct: 1414 QKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE-NRGLGERANLGRQFLEVELDQA 1472
Query: 748 EELLETGLIQV-ATKEEELNAIRTENSSLTKEVQDLKAK---------------QNDQVS 791
E L V A E L ++ E S +E++ + AK Q ++
Sbjct: 1473 REKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQK 1532
Query: 792 FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLE 851
+ VE+L+ E+ K VEEL + K+A+ ++ + +Q++KA++ + G Q E
Sbjct: 1533 LTAQVEQLEVFQREQT---KQVEELSK----KLADSDQASKVQQQKLKAVQAQGGESQQE 1585
Query: 852 KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
AQ+L +++ ELQ L KE+ K +E+ + + Q+LQE+ SL+
Sbjct: 1586 -AQRLQ--AQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQ 1642
Query: 912 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDV---QD 968
+E + + + ++ + KE E + L A ++ E+ ++ Q L+D+ Q
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQV 1702
Query: 969 ENKLFKSQIEQLKQQ 983
KS+ Q K Q
Sbjct: 1703 ATDALKSREPQAKPQ 1717
Score = 85.9 bits (211), Expect = 2e-16
Identities = 145/673 (21%), Positives = 273/673 (40%), Gaps = 88/673 (13%)
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
E L + +++LE +++A L T +S ++ + + K A L LK
Sbjct: 79 ECLVSAQKVLEGSELELAKMTMLLLYHSTMSSKSPRDWEQFEYKIQ-----AELAVILKF 133
Query: 802 VIHEKDGKI--KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSIT 859
V+ +DG + +E L+ + ++L K EI ++L+K S
Sbjct: 134 VLDHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSG 193
Query: 860 ------SKVQELQNLLKGKEEQMNTMKAVL-------EEKEKDLANTGKWLQDLQEENES 906
S + ++L+ + QM +K L +E E +LA K L + +
Sbjct: 194 NNFLSGSPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKLLTEKDAQIAM 253
Query: 907 LKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQL---L 963
++ + +A N K+A+S + +ELE + + E+ RL LK+ + + K+Q+ +
Sbjct: 254 MQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 964 QDVQDEN-------KLFKSQIEQLKQQ-NYQQASSFPPHEELLKVISEREKEISGLWNEL 1015
+ +EN + F S ++QL+ N +E L+ ++ EKE+S +
Sbjct: 314 NQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK 373
Query: 1016 DSLKDAVEHQRKKNNDLREKNWEAME------------------------ALASTEKMLQ 1051
L++ E + K + L E + + LA+ LQ
Sbjct: 374 KCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQ 433
Query: 1052 DKVNKTSKERQQQVEAVEL-------EAKEVLKKLFPKV-SVPSNLSYGE-------WLH 1096
+V ER QQ EA L E K+ L L + S SNLS + H
Sbjct: 434 ARVEMLETERGQQ-EAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAET----EGILQK 1152
G A+ S + E+ L +++ D+ L+ + ++ ++ LA+T E Q
Sbjct: 493 GARLTAQV----ASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
Query: 1153 LQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEME 1212
L+ VEQ + K K + + ++ +++ Q+L E E RER+ +
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER---EASLRERDAALKQ 605
Query: 1213 LEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTE 1272
LE E E++ + +++ + E + S ++A R+ EL+ +L + R E
Sbjct: 606 LEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQE 665
Query: 1273 QNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTV 1332
Q+E Q +L ++S+ KA V + D E + KE++ V+
Sbjct: 666 QHEAQAQVAELELQ------LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLE 719
Query: 1333 TQLQQLLQAVNQQ 1345
+ ++ A+ +Q
Sbjct: 720 EEKRRAADALEEQ 732
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 166 bits (420), Expect = 1e-40
Identities = 321/1429 (22%), Positives = 601/1429 (42%), Gaps = 228/1429 (15%)
Query: 106 ETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVT-------KQPTPPSEA 158
E +RE K++K L+EQ ++S ++ G ++ + + K P+ +
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 159 AASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKT 218
+ S PG ++ + +Q L S P H E G A K Q
Sbjct: 1256 SCSST-PGLEEPLFKATEQHHTQPVL--ESNLCPDWPSHSEDASALQGGTSVAQIKAQLK 1312
Query: 219 ENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKE 278
E + + L ++ +S + K E + L+ E I K G + +T
Sbjct: 1313 E-------IEAEKVELELKVSSTTSELTKKSEEVFQLQ----EQINKQGLEIESLKTVSH 1361
Query: 279 NAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGE--LTTLIHQLQE 336
AEV + SL+ + S + ++ L+E + + K SK E ++ L QL E
Sbjct: 1362 EAEVHAE----SLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
Query: 337 KDKLLAAVKEDAAATKDRCKQL-TQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIH 395
K+ L ++ + +D K L TQ M KE +RI L+ E + K
Sbjct: 1418 KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHD--------ERIKQLQVELCEMKQKPE 1469
Query: 396 VSYQET---QQMQMKFQQV---REQMEAEIAHLKQENGILRDAVSNTTNQL---ESKQSA 446
+E+ QQ+Q K Q R++ E L++E + R + T L ES+ SA
Sbjct: 1470 EIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSA 1529
Query: 447 ELNKLRQDYARLVNELTEKTGKLQQEE----VQKKNAEQAATQLKVQLQ----EAERRWE 498
+ NK + + L E+ KL E ++ ++ + LK+ L+ + E+ +
Sbjct: 1530 Q-NKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVK 1588
Query: 499 EVQSYIRKRTAE-------HEAAQQDLQSKFVAKEN-----------------EVQSLHS 534
E++S + AE H+ Q++ + + EN E Q L+
Sbjct: 1589 EIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG 1648
Query: 535 KLTDTLVSKQQLEQRLM---QLMESEQKRVNK-EESLQMQVQDILEQNEALKAQIQQFHS 590
KL T +K++ E++L Q ME ++++ K +S Q ++ ++ E+N+ L+A++
Sbjct: 1649 KLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGD 1708
Query: 591 QI-----AAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
+S + + EEL +V E + K+ + SL SE+D L+ + ++LK N
Sbjct: 1709 TAKECMETLLSSNASMKEELERVKMEYETLSKKFQ-SLMSEKDSLSEEVQDLKHQIEGNV 1767
Query: 646 LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILND 705
+A ++ + N+ + E+ QS+ + ++ L + S + K N
Sbjct: 1768 SKQANLEATEKHDNQ----TNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANP 1823
Query: 706 Q-NKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEE 764
+K S + L K+ + +E+ Q+ E +T+E T L Q++TK+ E
Sbjct: 1824 AVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGE 1883
Query: 765 LNAIR---TENSSLTKEVQD-----LKAKQNDQVSFASLVEELKKVIHEKDGKIKSV--- 813
L ++ T+ + L +++Q+ K K+ + L E L + E +G I +
Sbjct: 1884 LKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQD 1943
Query: 814 -------EELLEAELLK----VANKEKTVQDLKQEIKALKEEIGNVQLEKAQ----QLSI 858
ELLE+E+ V+ E+ Q L +E ++ EI LEK Q +
Sbjct: 1944 VTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGN 2003
Query: 859 TSKVQELQNLLKGKEEQMNTMKAVL---EEKEKDLANTGKWLQDLQEEN----ESLKAHV 911
S +ELQ LLK K++++ ++ +EK L T K L+ +Q E+ E K ++
Sbjct: 2004 KSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL 2063
Query: 912 QEVAQHNLKEASSASQFEELEIVLKEKENELKRLEA----MLKERESDLSS-KTQLLQDV 966
+ +H K + + F+ ++L + ++E R+ A + KE +S+ S K+Q+ Q
Sbjct: 2064 AQAVEHRKKAQAELASFK---VLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKD 2120
Query: 967 QD-ENKLFKSQIEQLKQQ-NYQQASSFPPHE---------ELLKVISEREKEISGLWNEL 1015
+D E +L +++ + LK++ N Q+ E E+ +++++KE+ L L
Sbjct: 2121 EDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENL 2180
Query: 1016 DSLKDAVEHQRKKNNDLRE---------KNWEAM--EALASTEK----------MLQDKV 1054
DS + K + L++ K WE +A+ S E+ +L+D++
Sbjct: 2181 DSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQL 2240
Query: 1055 NKTSKERQQ-QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGT---- 1109
+ S ++ ++ LE + + + + V + L G K+ + T
Sbjct: 2241 RQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLY 2300
Query: 1110 -SGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKV 1168
S E+ LE +LK + T L EK K EGI+++ + ++ + +
Sbjct: 2301 HSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY---- 2356
Query: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
E +T Q TS E ++ E K I L + E +++ + AE+ R + E++
Sbjct: 2357 -EQLETDLQASRELTSRLHEEINMK-EQKIISLLSGKEEAIQVAI--AEL-RQQHDKEIK 2411
Query: 1229 ELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRT----------------- 1271
EL++LL++ ++ E + EE + N+ + L+T
Sbjct: 2412 ELENLLSQEEE-------ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
Query: 1272 ----EQNERQKVAGDLHKAQQ-SLELIQSK---IVKAAGDTTVIEN---------SDVSP 1314
QN+R ++ GD + ++ L +I K I +AA + ++ D++
Sbjct: 2465 SMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNS 2524
Query: 1315 ETESSEKETMSV--SLNQTVT----QLQQLLQAVNQQLTKEKEHYQVLE 1357
E + E + LNQ +T Q +QLL+ QQ + + Y LE
Sbjct: 2525 ENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLE 2573
Score = 155 bits (391), Expect = 3e-37
Identities = 276/1362 (20%), Positives = 566/1362 (41%), Gaps = 180/1362 (13%)
Query: 38 LAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
L Q+ +++L K+ AE++K+ +E L E + ++DA ++++ +
Sbjct: 1896 LLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-QIKNELL 1954
Query: 98 APVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSE 157
N+ + S + E K++ K+K +E ++ KE KI G + EP K +
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEY-LEKIQGAQKEPG--NKSHAKELQ 2011
Query: 158 AAASKKKPGQKKSKNGSDDQDKKVETL--------MVPSKRQEALPLHQETKQESGSGKK 209
+K+ K+ + +K+ L V ++ Q+ L + +E ++ +K
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 210 KASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTK 269
KA ++ ++ L+D+ S + + L K Q
Sbjct: 2072 KAQAE---------------LASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQM 2116
Query: 270 KLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKG---- 325
K K E + E + L K M D L+E G IQ L K K
Sbjct: 2117 KQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL 2176
Query: 326 --ELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL 383
L + + QL K ++++++D D K+ ++ + I +D L
Sbjct: 2177 QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVL 2236
Query: 384 EKEH-----NVFQNKIHVSYQE-TQQMQMKFQQVREQMEAEIAH-LKQENGILRDAVSNT 436
+ + ++ + KI++S E +Q+ Q Q++ ++ L+ EN L + T
Sbjct: 2237 KDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEET 2296
Query: 437 TNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERR 496
+ S Q+ EL KL + L ++LT+ + L++ + QK N E Q + +Q ++
Sbjct: 2297 RHLYHSSQN-ELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFS 2355
Query: 497 WEEVQSYI---RKRTAE-HEAA---QQDLQSKFVAKENEVQSLHSKLT----------DT 539
+E++++ + R+ T+ HE +Q + S KE +Q ++L +
Sbjct: 2356 YEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELEN 2415
Query: 540 LVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQF-HSQIAAQTSA 598
L+S+++ E +++ E +K V+K L ++ I ++N KAQ+ F S + Q
Sbjct: 2416 LLSQEEEENIVLE--EENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDR 2473
Query: 599 SVLA------EELH-KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEV 651
+ EE H +I EKD+ I++ ++ + + D+ + N L AE+
Sbjct: 2474 DRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAEL 2533
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVK-----DDKIRLLEEQLQH-EISNK--MEEFKIL 703
+ + N+ +K V ++ ++K LEE+L+ E +N+ F L
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCI-------QEKDEKLKTVEELLETGLI 756
++ + L E++ L+ +S+ + Q E + + K+E++ + L +
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQK 2653
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
++A EEEL ++ E + E++D L +ELK +H G +++ E
Sbjct: 2654 RIAELEEELVCVQKEAAKKVGEIED------------KLKKELKH-LHHDAGIMRNETET 2700
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
E +VA + + +++Q++ + +E + AQ S + LQN E++
Sbjct: 2701 AEE---RVAELARDLVEMEQKLLMVTKENKGL---TAQIQSFGRSMSSLQNSRDHANEEL 2754
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA-QHNLKEASSASQFEELEIVL 935
+ +K + K+LA L++ N A + E A N E +S S E+L L
Sbjct: 2755 DELKRKYDASLKELAQ----LKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQL 2810
Query: 936 KEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQL------KQQNYQQAS 989
K+ +L L + L++ + + S ++ + +Q+E +++E+ KQ++ Q S
Sbjct: 2811 LSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPS 2870
Query: 990 SFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKM 1049
+ P + LK K +S L N+ D L +++ +++ + ++ E + L + +
Sbjct: 2871 TSPAEVQSLK------KAMSSLQNDRDRLLKELKNLQQQYLQINQEITE-LHPLKAQLQE 2923
Query: 1050 LQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW-LHGFEKKAKECMAG 1108
QDK K + Q+++ L + L +L + W +H K + MA
Sbjct: 2924 YQDK-TKAFQIMQEELRQENLSWQHELHQL--------RMEKSSWEIHERRMKEQYLMAI 2974
Query: 1109 TSGSEEVKVLEHKLKEADEMHTLLQ-LECEKYKSVLAETEGILQKLQRSVEQEE------ 1161
+ +++ L++ ++E + Q L+ + + ET Q V + E
Sbjct: 2975 SDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQL 3034
Query: 1162 NKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI-ENLRREREH----------LE 1210
N ++ + I+Q+ S+F+ +E L + D ++LR ++H LE
Sbjct: 3035 NDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLE 3094
Query: 1211 MEL------------------EKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQN 1252
++ EK + R + E+RE + +E Q++L ++
Sbjct: 3095 KQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNT-------- 3146
Query: 1253 EELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQ 1294
+ ++NE L E+++R L A++ + ++
Sbjct: 3147 ------RQEVNELRKLLEEERDQRVAAENALSVAEEQIRRLE 3182
Score = 151 bits (381), Expect = 5e-36
Identities = 255/1321 (19%), Positives = 555/1321 (42%), Gaps = 218/1321 (16%)
Query: 182 ETLMVPSK---RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMD 238
E L+V K RQ+ + L Q K E+ ++KA+ K K + L YI M
Sbjct: 58 EQLVVELKDIIRQKDVQLQQ--KDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEM- 114
Query: 239 NADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSE 298
A V+ +P E + K K TE + E ++K K + +
Sbjct: 115 KAQGGTVLPT-------EPQSEEQLSKHD--KSSTEEEMEIEKIKHK---------LQEK 156
Query: 299 DEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQL 358
+E + + ++ Q A + E + QLQEK++ ++ ++ A ++ + +Q
Sbjct: 157 EELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQ--AQLSQTQAEQA 214
Query: 359 TQEMMTEKE-RSNVVITRMKDRIGTLEKEHNV---FQNKIHV---SYQETQQMQMKFQQV 411
Q+++ EK+ R + +D + L + +V Q K+ V +E ++ + QV
Sbjct: 215 AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQV 274
Query: 412 REQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQ 471
+ ++ E+ +Q N IL S Q+E AE N LR E K++
Sbjct: 275 VDLLQQELTAAEQRNQIL----SQQLQQME----AEHNTLRNTVETEREESKILLEKMEL 326
Query: 472 EEVQKK----NAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE- 526
E ++K N ++ L Q ++A + E++S +H+A ++ S ++ +
Sbjct: 327 EVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQK 386
Query: 527 --NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQ 584
E+QS L D + + L+ + Q ++S Q E+ LQ + ++I + L Q
Sbjct: 387 TGQELQSACDALKDQ--NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQ 444
Query: 585 IQQFHSQIAAQTS-ASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNM 643
+ A+QTS V E V E +++ L +E+ L EL++++
Sbjct: 445 ----QHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAE 500
Query: 644 NFLLKAEVQKLQA------------------LANEQAAAAH----------------ELE 669
N L +++ L+A +AN+++++A EL
Sbjct: 501 NEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELS 560
Query: 670 KMQQSVYVKDDKIRLLEEQLQ--------HEISNKMEEFKILNDQNKALKSEV------Q 715
+ + ++I L+ QLQ HE+ ++ E ++ + +K +V Q
Sbjct: 561 VLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQ 620
Query: 716 KLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE---ELNAIRTEN 772
+ +E+ + VE+ E+ E + L + G+ +TK++ L+A+
Sbjct: 621 DFPLMPNEESSLPAVEK-EQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIG 679
Query: 773 SSLTKEVQDLKAKQND-QVSFASLVEELKKVIHEKDGKIKSVEELLEA------------ 819
E++ LK++ + +++F E +K + EK +I ++ +L+E
Sbjct: 680 QCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAF 739
Query: 820 --------ELLKVANKEKTVQDLKQEIKALKEEIGNVQLEK--------AQQLSITSKVQ 863
+LL + V +L+ ++K L+ + + ++ A +T ++
Sbjct: 740 TALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIH 799
Query: 864 ELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS 923
L K K+ ++ ++ L++ + + ++ LQ + ++ ++ V E A+ +
Sbjct: 800 SLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAE---RVRH 856
Query: 924 SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLL----QDVQDENKLFKSQIEQ 979
+S+ EEL L +KE E+ +++ +L E++ D+ + Q + Q V + + ++ Q
Sbjct: 857 ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQ 916
Query: 980 LKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEA 1039
L ++ + +E L ++S E ++ K+ VE + ++ L++ E
Sbjct: 917 LNEEKFSLGVEIKTLKEQLNLLSRAE----------EAKKEQVEEDNEVSSGLKQNYDEM 966
Query: 1040 MEALASTEKMLQ---DKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLH 1096
A +++ LQ D + K +++R+++++A + KE+L+++ +NL
Sbjct: 967 SPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLK------ 1020
Query: 1097 GFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKY-KSVLAETEGILQKLQR 1155
++ KE + EV+ + + +++ T E E Y K ++E E LQ +++
Sbjct: 1021 --DESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRK 1078
Query: 1156 SVEQE---ENKWKVKVDESHKTIKQ-------MQSSFTSSEQELERLRSENKDIEN---- 1201
+E++ E +++ V + ++T++ +Q+ + ++ +++L + N D +
Sbjct: 1079 DLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSV 1138
Query: 1202 ------------------------------LRREREHLEMELEKAEMERSTYVTEVRELK 1231
L +E+E L+ +L++A R + + +E +
Sbjct: 1139 ALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKE 1198
Query: 1232 DLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQ--- 1288
L E K+ D Y+ Q +E + + + L +L+ + R+ + G L Q
Sbjct: 1199 RHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQ--VRESIDGKLPSTDQQES 1256
Query: 1289 --SLELIQSKIVKAAGD--TTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQ 1344
S ++ + KA T + S++ P+ S ++ ++ +V Q++ L+ +
Sbjct: 1257 CSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEA 1316
Query: 1345 Q 1345
+
Sbjct: 1317 E 1317
Score = 134 bits (337), Expect = 6e-31
Identities = 294/1394 (21%), Positives = 576/1394 (41%), Gaps = 171/1394 (12%)
Query: 36 EVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGN-LHESDSESVPRDFKLSDALAVED 94
E L Q E +L K + + K KEI N N L E ++ + AL+ E
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 95 DQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTP 154
DQ+ L+ V+ S V E + + K+ + L E + + +T+Q
Sbjct: 747 DQL----LSQVKELSMVTELRAQVKQLEMNLAEA--ERQRRLDYESQTAHDNLLTEQIHS 800
Query: 155 PSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSK 214
S A SK + D Q + E + Q L + E + SSK
Sbjct: 801 LSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSK 860
Query: 215 KQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL------KPDQVEGIQKSGT 268
++ + L I MD +++K+ ++ L K QV I S T
Sbjct: 861 VEELSQALSQKEL-----EITKMDQL----LLEKKRDVETLQQTIEEKDQQVTEISFSMT 911
Query: 269 KKL-KTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKE-KSGVIQDALKKSSKGE 326
+K+ + +K + V+ K L + +E+ V+ E SG+ Q+ + S G+
Sbjct: 912 EKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQ 971
Query: 327 LTT--LIHQL--------QEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRM 376
++ L H+ Q K KL AA+ + R +L +E+ K+ S I
Sbjct: 972 ISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQ-RVSRLEEELANLKDESKKEIPLS 1030
Query: 377 KDRIGTLE--KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
+ G +E KE+ + K S + Q++++ +Q + E E+ H++++
Sbjct: 1031 ETERGEVEEDKENKEYSEKCVTS--KCQEIEIYLKQTISEKEVELQHIRKD--------- 1079
Query: 435 NTTNQLESKQSAELNKLRQDYARLVNE----LTEKTGKLQQEEVQKKNAEQAATQLKVQL 490
LE K +AE + + LV + L +KT ++ + +Q + +E A K+
Sbjct: 1080 -----LEEKLAAE-----EQFQALVKQMNQTLQDKTNQI--DLLQAEISENQAIIQKLIT 1127
Query: 491 QEAERRWEEVQSYIRKR-------TAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSK 543
+ + + +++ T E + +L+ K +A E E + L KL + L S+
Sbjct: 1128 SNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSR 1187
Query: 544 QQL----EQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQ---- 595
+ + +++ L E +++ + LQ Q + ++NE + Q++Q Q+
Sbjct: 1188 KAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGK 1247
Query: 596 ----------TSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNF 645
+S L E L K + Q E +L + S E+ +Q
Sbjct: 1248 LPSTDQQESCSSTPGLEEPLFKATEQHHTQ-PVLESNLCPD---WPSHSEDASALQGGTS 1303
Query: 646 L--LKAEVQKLQA----LANEQAAAAHELEKMQQSVYVKDDKIRL--LEEQLQHEISNKM 697
+ +KA++++++A L + ++ EL K + V+ ++I LE + +S++
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEA 1363
Query: 698 E-EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI 756
E + L + ++ + ++ L+ L QP D +++K I +K+E + +
Sbjct: 1364 EVHAESLQQKLESSQLQIAGLEHLRELQPKLD---ELQKLISKKEEDVSYLSG------- 1413
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
Q++ KE L I+TE E +DL +L +L+ E D +IK
Sbjct: 1414 QLSEKEAALTKIQTE----IIEQEDL---------IKALHTQLEMQAKEHDERIKQ---- 1456
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
L+ EL ++ K + + + + + ++ ++ + + + L +QE +L +G E++
Sbjct: 1457 LQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERL 1516
Query: 877 NTMKAVLEE------KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
A +E KEKD G+ L LQEE + L + E+ + L+ S +S E
Sbjct: 1517 TKSLADVESQVSAQNKEKDTV-LGR-LALLQEERDKL---ITEMDRSLLENQSLSSSCES 1571
Query: 931 LEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASS 990
L++ L E + E ++KE ES SSK + Q+++K + + E L Q ++
Sbjct: 1572 LKLAL---EGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE 1628
Query: 991 FPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKML 1050
+ +++ + + ++E+ G ++ K E Q ++ E+ E M A +++
Sbjct: 1629 AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQK 1688
Query: 1051 QDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWL-------HGFEKKAK 1103
++ + + + +V AKE ++ L + SN S E L KK +
Sbjct: 1689 ILELEEENDRLRAEVHPAGDTAKECMETL-----LSSNASMKEELERVKMEYETLSKKFQ 1743
Query: 1104 ECMA-GTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEEN 1162
M+ S SEEV+ L+H+++ L+ EK+ + TE Q + E++++
Sbjct: 1744 SLMSEKDSLSEEVQDLKHQIEGNVSKQANLE-ATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 1163 ---KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEME 1219
+ ES + K + + + + + + I+ L+ LE E +K
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQK---N 1859
Query: 1220 RSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKV 1279
+ T E LL+++ K D + ++NLL Q+ E L+++ + ++
Sbjct: 1860 KEFSQTLENEKNTLLSQISTK-DGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEE 1918
Query: 1280 AGDL-HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQL 1338
DL + L + I D T ++ + E SE + + +++ + QQL
Sbjct: 1919 KDDLEERLMNQLAELNGSIGNYCQDVT---DAQIKNELLESEMKNLKKCVSELEEEKQQL 1975
Query: 1339 LQ---AVNQQLTKE 1349
++ V ++ KE
Sbjct: 1976 VKEKTKVESEIRKE 1989
Score = 124 bits (312), Expect = 5e-28
Identities = 206/1116 (18%), Positives = 469/1116 (42%), Gaps = 211/1116 (18%)
Query: 387 HNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSA 446
+N Q + +Q+ ++ + + Q + ++ + R A N +L+ A
Sbjct: 43 NNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA 102
Query: 447 ELNKLRQDYARLVNELTEKTGKL----QQEEVQKKNAEQAATQLKVQLQEAERRWEEVQS 502
+L L + + E+ + G + Q E Q ++++T+ ++++++ + + +E +
Sbjct: 103 KLTSLN----KYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEE 158
Query: 503 YIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVN 562
I A+ AQ E QS +++ + ++ KQQL+++ + + + Q +++
Sbjct: 159 LISTLQAQLTQAQA---------EQPAQS-STEMEEFVMMKQQLQEK-EEFISTLQAQLS 207
Query: 563 KEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDS 622
+ ++ Q Q + E++ + Q++ ++ + + + E+ + + +++++ E+S
Sbjct: 208 QTQAEQAAQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEES 267
Query: 623 LASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
L + ++EL + N +L ++Q+++A E ++ +V + ++
Sbjct: 268 LVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEA----------EHNTLRNTVETEREES 317
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNK-DVVEQMEKCIQEKD 741
++L E+++ E++ + F L ++ L + ++ +E ++ +EQ K E +
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKA--EME 375
Query: 742 EKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKK 801
EK + L +TG + +A++ +NS L L+ K V A +++L+
Sbjct: 376 EKTSHILSLQKTG----QELQSACDALKDQNSKL------LQDKNEQAVQSAQTIQQLED 425
Query: 802 VIHEKDGKIKSVEELLEAELLKVANK---------------EKTVQDLKQEIKALKEEIG 846
+ +K +I L + + A++ E+ + L++ + L+ E G
Sbjct: 426 QLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKG 485
Query: 847 -----NVQLE--KAQQLSITSKVQ--ELQNLL---------------------KGKEEQM 876
+++LE KA+ ++S++ E QN +E
Sbjct: 486 ALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQ 545
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ----EVAQHNLKEASSASQFE--- 929
+ ++ +K K+L+ +++ QEE LK +Q E A H + + Q E
Sbjct: 546 DVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEG 605
Query: 930 ----ELEIVLKE-------KENELKRLEAMLKERES------------------DLSSKT 960
++++ L++ NE L A+ KE+ S +L S
Sbjct: 606 IAPIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTK 665
Query: 961 Q----LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELL-KVISEREKEISGLWNEL 1015
Q L V D + + ++E+LK Q + +F +E+ K + E+ KEIS L
Sbjct: 666 QDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNL---- 721
Query: 1016 DSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS--KERQQQVEAVEL--- 1070
+ + + KKN D N A AL+ L +V + S E + QV+ +E+
Sbjct: 722 ----NQLIEEFKKNAD---NNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLA 774
Query: 1071 EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHT 1130
EA+ + + + NL E +H +AK S +++VL+++L +
Sbjct: 775 EAERQRRLDYESQTAHDNL-LTEQIHSLSIEAK------SKDVKIEVLQNELDD------ 821
Query: 1131 LLQLECEKYKSVLAETEGILQKLQRSVEQEENKWK---VKVDESHKTIKQMQSSFTSSEQ 1187
+QL+ + +++ + LQ + V + + + KV+E + + Q + T +Q
Sbjct: 822 -VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQ 880
Query: 1188 ELERLRSENKDIENLRREREHLEMELEKAEM-----------ERSTYVTEVRELKDLLTE 1236
L + +D+E L++ E + ++ + E+ + E++ LK+ L
Sbjct: 881 ---LLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNL 937
Query: 1237 L---------QKKLDDSYSEAVRQN----------------EELNLLKAQLNETLTKLRT 1271
L Q + D+ S ++QN E +LLK + + KL+
Sbjct: 938 LSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQA 997
Query: 1272 EQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV--------IENSDVSPETESSEKET 1323
R+++ + + ++ L ++ + K + EN + S + +S+ +
Sbjct: 998 ALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQE 1057
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKE---KEHYQVL 1356
+ + L QT+++ + LQ + + L ++ +E +Q L
Sbjct: 1058 IEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQAL 1093
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 162 bits (410), Expect = 2e-39
Identities = 225/1126 (19%), Positives = 503/1126 (44%), Gaps = 172/1126 (15%)
Query: 308 LKEKSGVIQDALKKSS--KGELTT-LIHQLQEKDKL---LAAVKEDAAATKDRCKQLTQ- 360
+KE+ G I++ L+KS + EL ++ LQEK+ L + A +++ ++RC QL +
Sbjct: 854 MKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKN 913
Query: 361 ------------EMMTEKERSNVVIT----RMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
E + ++E N +T +++D L+K+ + + + +E
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 973
Query: 405 QMKFQQVREQM---EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNE 461
+ K + + E+M + IA L +E L++A + L+ ++ ++N L + +L +
Sbjct: 974 ENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEED-KVNSLSKSKVKLEQQ 1032
Query: 462 LTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSK 521
+ + G L+QE+ ++++ L+ A+R+ E ++ + E + L+ K
Sbjct: 1033 VDDLEGSLEQEK-----------KVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEK 1081
Query: 522 FVAKENEVQSLHSKLTDTLVSKQQLEQRLMQ---LMESEQKRVNKEESLQMQVQ----DI 574
KE ++ +SK+ D V QL+++L + +E ++ + E + + +V+ D+
Sbjct: 1082 LKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDL 1141
Query: 575 LEQNEALKAQIQQFHSQIAAQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DR 629
+ E + ++++ + Q + E E K+ + ++ Q E + A+ R D
Sbjct: 1142 SRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADS 1201
Query: 630 LTSKEEELKDIQNMNFLL-------KAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKI 682
+ E++ ++Q + L K E+ + + + A LEK+ +++ + ++
Sbjct: 1202 VAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEY 1261
Query: 683 RLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE--QPNKDVVEQMEKCIQEK 740
R+ E+ Q +++ + L +N L ++++ + L+S+ + +QME ++
Sbjct: 1262 RVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQL 1321
Query: 741 DEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTK-EVQDLKAKQNDQVS-------- 791
+E+ K L +Q A + +L + E + K E+Q + +K N +V+
Sbjct: 1322 EEEGKAKNALAHA--LQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1379
Query: 792 -FASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI----- 845
EEL++ + +++ EE +EA K ++ EKT L+ EI+ L ++
Sbjct: 1380 DAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1439
Query: 846 GNVQLEKAQQ------LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQD 899
L+K Q+ K +E Q+ L+ +++ ++ L + + + + L+
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLET 1499
Query: 900 LQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSK 959
+ EN++L+ + ++ + + ELE V K+ E E L++ L+E E+ L
Sbjct: 1500 FKRENKNLQEEISDLTE---QLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE-- 1554
Query: 960 TQLLQDVQDENKLFKSQIE--QLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDS 1017
+E K+ ++Q+E Q+K + ++ + EE+ + ++ + L LD+
Sbjct: 1555 -------HEEGKILRAQLEFNQIKAEIERKLAE--KDEEMEQAKRNHQRVVDSLQTSLDA 1605
Query: 1018 LKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLK 1077
R +N LR K + ME + ++ N+ + E Q+QV++++ K+
Sbjct: 1606 ------ETRSRNEVLRVK--KKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQI 1657
Query: 1078 KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECE 1137
+L V +L E + ++E + + LLQ E E
Sbjct: 1658 QLDDAVRANDDL----------------------KENIAIVERR-------NNLLQAELE 1688
Query: 1138 KYKSVLAETEGILQKLQRSVEQE--ENKWKVKVDESHKTI-----KQMQSSFTSSEQELE 1190
+ ++V+ +TE + ++ EQE E +V++ S T K+M+S T + E+E
Sbjct: 1689 ELRAVVEQTE----RSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVE 1744
Query: 1191 RLRSENKDIENLRRER---EHLEMELEKAEMERSTYVTEVRE-LKDLLTELQKKLDDSYS 1246
E ++ E ++ + E K E + S ++ +++ ++ + +LQ +LD++
Sbjct: 1745 EAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQ 1804
Query: 1247 EAVR-QNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTT 1305
A++ ++L L+A++ E +L EQ + + K+++ ++
Sbjct: 1805 IALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIK-------------- 1850
Query: 1306 VIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKE 1351
+++ +TE +K + L V +LQ ++A +Q + +E
Sbjct: 1851 -----ELTYQTEEDKKNLL--RLQDLVDKLQLKVKAYKRQAEEAEE 1889
Score = 159 bits (401), Expect = 2e-38
Identities = 241/1181 (20%), Positives = 524/1181 (44%), Gaps = 157/1181 (13%)
Query: 180 KVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDN 239
K++ L+ ++ ++ + +E +K+ +++++ E V L+ + L
Sbjct: 837 KIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVS--LLQEKNDLQLQVQ 894
Query: 240 ADSSPVVDKREVIDLLKPD--QVEGIQKSGTKKLKTETDKENAEV-----KFKDFLLSLK 292
A+ + D E D L + Q+E K ++L+ E ++ NAE+ K +D LK
Sbjct: 895 AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDE-EEMNAELTAKKRKLEDECSELK 953
Query: 293 TMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATK 352
+ +D L + + KEK +++ ++ L ++ D+++A + ++ A +
Sbjct: 954 KDI--DDLELTLAKVEKEKH---------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQ 1002
Query: 353 DRCKQLTQEMMTEKERSNVVIT-------RMKDRIGTLEKEHNV------FQNKIHVSYQ 399
+ +Q ++ E+++ N + ++ D G+LE+E V + K+ +
Sbjct: 1003 EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLK 1062
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELN---KLRQDYA 456
TQ+ M + + Q+E ++ + + ++ +++E +Q L KL+++ A
Sbjct: 1063 LTQESIMDLENDKLQLEEKLKKKEFD-------INQQNSKIEDEQVLALQLQKKLKENQA 1115
Query: 457 RLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYI-------RKRTA 509
R + EL E+ L+ E + E+ + L +L+E R EE +KR A
Sbjct: 1116 R-IEELEEE---LEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 510 EHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
E + ++DL+ + E +L K D++ +L +++ L +QK ++ ++
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVA---ELGEQIDNLQRVKQKLEKEKSEFKL 1228
Query: 570 QVQDI---LEQNEALKAQIQQFHSQIAAQTSA-SVLAEELHKVIAEKDKQIKQTEDSLAS 625
++ D+ +EQ KA +++ + Q + V EE + + + Q + +
Sbjct: 1229 ELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Query: 626 ERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
+L KE + + +++ L+ E+ A + L QS D LL
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCD---LL 1345
Query: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLK 745
EQ + E K E ++L+ N + K +T ++ E++E+ ++ ++L+
Sbjct: 1346 REQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQR-----TEELEEAKKKLAQRLQ 1400
Query: 746 TVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QNDQVSFASLVEELKK 801
EE +E + ++ E+ + ++ E L +V+ A Q +F ++ E K+
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ 1460
Query: 802 VIHEKDGKIKSVEE---LLEAELLKVANK-EKTVQDL---KQEIKALKEEIGNVQLEKAQ 854
E +++S ++ L EL K+ N E++++ L K+E K L+EEI ++ +
Sbjct: 1461 KYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL----TE 1516
Query: 855 QLSITSK-VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQE 913
QL K V EL+ + K E + +++ LEE E L + + Q E +KA +
Sbjct: 1517 QLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEI-- 1574
Query: 914 VAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQD-ENKL 972
E A + EE+E + K N + ++++ +++ S+ ++L+ + E L
Sbjct: 1575 -------ERKLAEKDEEME---QAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDL 1624
Query: 973 FKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1032
+ +I QL N A + + L ++ + + ++ D LK+ + ++NN L
Sbjct: 1625 NEMEI-QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLL 1683
Query: 1033 REKNWEAMEALASTE---KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNL 1089
+ + E + TE K+ + ++ +TS E V+L + + K + S+L
Sbjct: 1684 QAELEELRAVVEQTERSRKLAEQELIETS-------ERVQLLHSQNTSLINQKKKMESDL 1736
Query: 1090 SYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGI 1149
+ + + +E + +E + E K K+A ++ E +K + +T
Sbjct: 1737 TQ------LQSEVEEAV------QECRNAEEKAKKAITDAAMMAEELKKEQ----DTSAH 1780
Query: 1150 LQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN-----LRR 1204
L+++++++EQ + ++DE+ Q + +++L++L + +++E +R
Sbjct: 1781 LERMKKNMEQTIKDLQHRLDEAE------QIALKGGKKQLQKLEARVRELEGELEAEQKR 1834
Query: 1205 EREHLE-MELEKAEMERSTYVTE-----VRELKDLLTELQKKLDDSYSEAVRQNEELNLL 1258
E ++ M + ++ TY TE + L+DL+ +LQ K+ +Y + EE
Sbjct: 1835 NAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVK-AYKRQAEEAEE---- 1889
Query: 1259 KAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVK 1299
Q N L+K R KV +L +A++ ++ +S++ K
Sbjct: 1890 --QANTNLSKFR-------KVQHELDEAEERADIAESQVNK 1921
Score = 97.4 bits (241), Expect = 8e-20
Identities = 163/831 (19%), Positives = 339/831 (40%), Gaps = 121/831 (14%)
Query: 107 TSSSVRERKKKE---KKQKPVLEEQVIK-ESDASKIPGKKVEPVPVTKQPTPPSEAAASK 162
TS + KK+E +K + LEE ++ E+ A+ + K + V + + K
Sbjct: 1159 TSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQK 1218
Query: 163 KKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVF 222
+ + + K DD +E ++ K + L T ++ + + + Q++ N F
Sbjct: 1219 LEKEKSEFKLELDDVTSNMEQII---KAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDF 1275
Query: 223 VDEPLIHATTYIPLMDNADSSPVVDKREVI-------DLLKPDQVEGIQKSGTKKLKTET 275
+ T +N + + ++++E + L Q+E +++ ++ K +
Sbjct: 1276 TTQRAKLQT------ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKN 1329
Query: 276 DKENAEVKFKDFLLSLKTMMFSEDEALCVVD--LLKEKSGVIQ-------DALKKSSKGE 326
+A + L+ E EA + L K S V Q DA++++ + E
Sbjct: 1330 ALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELE 1389
Query: 327 LTT--LIHQLQEKDKLLAAVKEDAAA---TKDRCKQLTQEMMTEKERSNVVITRMKDRIG 381
L +LQ+ ++ + AV ++ TK R + +++M + ERSN + +
Sbjct: 1390 EAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449
Query: 382 TLEK-------EHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHL---KQENGILRD 431
+K ++ Q+++ S +E + + + +++ E + HL K+EN L++
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQE 1509
Query: 432 AVSNTTNQLES--KQSAELNKLRQ----DYARLVNELTEKTGKLQQEEVQKKNAEQAATQ 485
+S+ T QL K EL K+R+ + L + L E L+ EE + A+ Q
Sbjct: 1510 EISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569
Query: 486 LKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAK---ENEVQSLHSKLTDTLVS 542
+K ++ ER+ E + + H+ LQ+ A+ NEV + K+ L
Sbjct: 1570 IKAEI---ERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNE 1626
Query: 543 KQQLEQRLMQLMESEQKRVNKEESL----QMQVQDILEQNEALK---AQIQQFHSQIAAQ 595
+ ++ QK+V +SL Q+Q+ D + N+ LK A +++ ++ + A+
Sbjct: 1627 MEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE 1686
Query: 596 TSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQ 655
EEL V+ + ++ K E L +R+ Q
Sbjct: 1687 L------EELRAVVEQTERSRKLAEQELIETSERV------------------------Q 1716
Query: 656 ALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ-NKALKSEV 714
L ++ + ++ +KM+ + QLQ E+ ++E + ++ KA+
Sbjct: 1717 LLHSQNTSLINQKKKMESDL-----------TQLQSEVEEAVQECRNAEEKAKKAITDAA 1765
Query: 715 QKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSS 774
+ L EQ +E+M+K +++ + L+ L E I + +++L +
Sbjct: 1766 MMAEELKKEQDTSAHLERMKKNMEQTIKDLQ--HRLDEAEQIALKGGKKQLQKLEARVRE 1823
Query: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
L E++ + + + V K + + + +IK + E + + + V L
Sbjct: 1824 LEGELEAEQKRNAESV----------KGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKL 1873
Query: 835 KQEIKALKEEIGNVQLEKAQQLSITSKVQ----ELQNLLKGKEEQMNTMKA 881
+ ++KA K + + + LS KVQ E + E Q+N ++A
Sbjct: 1874 QLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRA 1924
Score = 40.4 bits (93), Expect = 0.012
Identities = 51/247 (20%), Positives = 106/247 (42%), Gaps = 35/247 (14%)
Query: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR---SVEQEENKWKVKVDE 1170
++K L + EM T+ + E + K L ++E ++L+ S+ QE+N +++V
Sbjct: 837 KIKPLLKSAETEKEMATMKE-EFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQA 895
Query: 1171 SHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230
Q + +E+ ++L +E +E + LE E + + R+L
Sbjct: 896 E-------QDNLNDAEERCDQLIKNKIQLEAKVKE---MNERLEDEEEMNAELTAKKRKL 945
Query: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSL 1290
+D +EL+K +DD L TL K+ E++ + +L + L
Sbjct: 946 EDECSELKKDIDD------------------LELTLAKVEKEKHATENKVKNLTEEMAGL 987
Query: 1291 ELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEK 1350
+ I +K+ K + ++ + + +E SL+++ +L+Q + + L +EK
Sbjct: 988 DEIIAKLTK---EKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEK 1044
Query: 1351 EHYQVLE 1357
+ LE
Sbjct: 1045 KVRMDLE 1051
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 161 bits (407), Expect = 5e-39
Identities = 247/1159 (21%), Positives = 507/1159 (43%), Gaps = 195/1159 (16%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVI--------------QD 317
T+ +E+ E K+ L LK ++ DE + +++L +E+ G+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 318 ALKKS------------SKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
+K++ +K ++ L +L+EK + L K++ + K+L QE M
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 366 KERSNVVITRM-KDRIGTL-EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
S+ RM +D + L EK V + + VS + + ++F + R + LK
Sbjct: 299 L--SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR------VEELK 350
Query: 424 QENGILRDAVSNTTNQLESKQ--SAELNKLRQDYARLVN-----ELTEKTGKLQQEEVQK 476
++N +L + + +QLE + S +L++L ++ +L E+ + + EE+ +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAE-HEAAQQDL--------QSKFVAKEN 527
+N Q + + WE Q RT+E EA Q+ L S+ + E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQI---SRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL------ 581
E QSL + + + +E ++++ E++ + +++ +I+++ ++L
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 582 -------KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
KAQ+++ + + + K++ ++++ + QT SL +R ++ S E
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQI------KILEQENEHLNQTVSSLR-QRSQI-SAE 579
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EI 693
+KDI+ N +L +++ + ++ +++K + K ++ LE +L H E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
N++ + KI N LK +K++ L EQ N + ++ ++ KLK + +
Sbjct: 640 ENELLQKKITN-----LKITCEKIEAL--EQENSE--------LERENRKLKKTLDSFKN 684
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Q+ + E+E + + EN L + V+ LK + A L E K++ EK+ ++K
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCAS---MKMAQLQLENKELESEKE-QLKKG 740
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
ELL+A K E + Q L +I N +L+K + S K+Q+L++ L+ E
Sbjct: 741 LELLKASFKKTERLEVSYQGL---------DIENQRLQKTLENS-NKKIQQLESELQDLE 790
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 933
+ T++ LEE L + K L+ L++EN+SL+ QE +Q LE
Sbjct: 791 MENQTLQKNLEE----LKISSKRLEQLEKENKSLE---QETSQ--------------LEK 829
Query: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
K+ E E KRL + +++ L + +++ ENK +I K+ +
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053
++EL+K + K + L +L S K + NNDL + E + + E++L D+
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQM---NNDLEKLTHELEKIGLNKERLLHDE 946
Query: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113
T R + +E+ + + LKK + KE E
Sbjct: 947 -QSTDDSRYKLLES---KLESTLKKSL--------------------EIKE--------E 974
Query: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKS---VLAETEGILQKLQRS--VEQEENKWKVKV 1168
++ LE +L+E+ + L+ E + K L + + + +Q S + E+NKW+ +
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
E+ + + +++ +RL ++ L+ E++ L+ +L++ E + + ++
Sbjct: 1035 QETTRELLKVK----------DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1084
Query: 1229 ELKDLLTELQKK---LDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
L+ LQ++ L ++ +N LN L +L +Q+ + + K
Sbjct: 1085 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1144
Query: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQ- 1344
++ L+ + ++K E ++ E ++SE E++ +S + T+ + L+ ++
Sbjct: 1145 EREDLKSLYDSLIKDH------EKLELLHERQASEYESL-ISKHGTLKSAHKNLEVEHRD 1197
Query: 1345 ------QLTKEKEHYQVLE 1357
QL K+K + LE
Sbjct: 1198 LEDRYNQLLKQKGQLEDLE 1216
Score = 147 bits (372), Expect = 5e-35
Identities = 235/1076 (21%), Positives = 438/1076 (40%), Gaps = 145/1076 (13%)
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
DQ+EG + K E +KEN ++K K L M D ++ L E++ ++
Sbjct: 365 DQLEGTRARSDKL--HELEKENLQLKAK-----LHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A +K S E L +L++ + + + +LT + + E N +T+
Sbjct: 418 A-QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 378 DRIGT--------------LEKEHNVFQNKIHVS---------------------YQETQ 402
+ + T +EKE+ K+ + +E
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Q++ + +RE E +I L+QEN L VS+ + + A + + ++ L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
E + KL + E +K+ ++ K E R EE+++ + E+E Q+ + +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 523 VAKE---------NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
+ E +E++ + KL TL S + L +L + +E E ++++E + +
Sbjct: 653 ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKENSQLDEENLELRRNVE 711
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK 633
L+ AQ+Q + ++ ++ EL K +K ++++ + L E RL
Sbjct: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQ-- 769
Query: 634 EEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQ---LQ 690
K ++N N ++ +LQ L E LE+++ + ++ LE++ L+
Sbjct: 770 ----KTLENSNKKIQQLESELQDLEMENQTLQKNLEELK----ISSKRLEQLEKENKSLE 821
Query: 691 HEISNKMEEFKILNDQNKALKSEVQKLQTLVS---------EQPNKDVVEQM----EKCI 737
E S ++ K L +NK L+ + + T + E+ NK + +++ E C+
Sbjct: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
Query: 738 QEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVE 797
+ K E K +EL++ I + T + T L E + ND +E
Sbjct: 882 RLK-ELEKENKELVKRATIDIKT-------LVTLREDLVSEKLKTQQMNNDLEKLTHELE 933
Query: 798 EL----KKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLK-QEIKALKEEIGNVQLEK 852
++ ++++H++ S +LLE++L K +++ K ++A EE N +
Sbjct: 934 KIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQL 993
Query: 853 AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQ 912
Q+L K E + +E + + + E KW ++ QE L
Sbjct: 994 RQELKTVKKNYEALKQRQDEERMVQSSPPISGE-------DNKWERESQETTRELLKVKD 1046
Query: 913 EVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM---LKERESDLSSKTQLLQ----D 965
+ + A+ ++ + L+ LK+ E + L+A L+ + L + LQ
Sbjct: 1047 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1106
Query: 966 VQDENKLFKSQIEQLKQQNYQ---QASSFPPHEELLKVISEREKEISGLWNELDSLKDAV 1022
+Q EN SQ L QN Q Q SS E VI ERE +L SL D++
Sbjct: 1107 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE--SVIKERE--------DLKSLYDSL 1156
Query: 1023 EHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAK--EVLKKLF 1080
+K L E+ E+L S L+ S + +VE +LE + ++LK+
Sbjct: 1157 IKDHEKLELLHERQASEYESLISKHGTLK------SAHKNLEVEHRDLEDRYNQLLKQKG 1210
Query: 1081 PKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEM-HTLLQLECEKY 1139
+ L + E K E +A E K L E D + HT QL K
Sbjct: 1211 QLEDLEKMLKVEQEKMLLENKNHETVAA-----EYKKL---CGENDRLNHTYSQL--LKE 1260
Query: 1140 KSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDI 1199
VL L+ L + + E+ + + + + + +Q+ + T + E L S+ K
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE-LLSQLKG- 1318
Query: 1200 ENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEEL 1255
NL E HL +++ ++ T + + E KDL Q++ D +E RQ E+L
Sbjct: 1319 -NLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1373
Score = 129 bits (323), Expect = 2e-29
Identities = 236/1143 (20%), Positives = 486/1143 (42%), Gaps = 143/1143 (12%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHE-SDSESVPRDFKLSDALAVEDDQVA 98
+Q+ E+K K++ E+ + + K +Q N++ SD+ S DAL + +V
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVD 323
Query: 99 PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEA 158
+ V S +ER + K +EE +KE + + K + + +
Sbjct: 324 KLESEV----SRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 159 AASKKKPGQKKSKNGSDDQD-----KKVETLM-------VPSKRQEALPLHQETKQESGS 206
+K+ Q K+K + + KK+E LM + K+ LH + E S
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
Query: 207 GKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKS 266
+ S QK+ V+E + + + + + V + R +D VEG +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD-----SVEG---N 489
Query: 267 GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV---VDLLKEKSGVIQ--DALKK 321
+K LK E KEN + K +L + + + C DL+KEK+ + + + L++
Sbjct: 490 ASKILKME--KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRM---- 376
+S+ ++ L + + ++ ++++++ + + + R K + +E E +++
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 377 -KDRIGTLEKEH--------NVFQNKIHVSYQETQQMQMKFQQVR------EQMEAEIAH 421
+ R E EH +N++H +E + +Q K ++ E +E E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 422 LKQENGILR---DAVSNTTNQLES--KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
L++EN L+ D+ N T QLES K++++L++ + R V L + K+ Q +++
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 477 KNAEQAATQLKVQLQ------------EAERRWEEVQSYIRKRTAEHEAAQ-QDLQSKFV 523
K E QLK L+ E + ++++ ++T E+ + Q L+S+
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 524 AKENEVQSLHSKLTDTLVSKQQLEQ---------RLMQLMESEQKRVNKEESLQMQVQDI 574
E E Q+L L + +S ++LEQ + +E ++K++ KE Q +I
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Query: 575 ----LEQNEA----LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
LE+N L+ + + +I + V +EL K E K+ +L +
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKL-----QALANEQAA-------AAHELEK-MQQ 673
R+ L S++ + + + N L E++K+ + L +EQ+ +LE +++
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKK 967
Query: 674 SVYVKDDKIRLLEEQLQHEISNKME---EFKILNDQNKALKSEVQKLQTLVSEQPNKDVV 730
S+ +K++KI LE +L+ + + E K + +ALK + + + S P
Sbjct: 968 SLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED 1027
Query: 731 EQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----Q 786
+ E+ QE +L V++ L AT + E A++T+ L + +L+A+ Q
Sbjct: 1028 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1087
Query: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE------------------ 828
VS ++E + ++ K++ L ++ + N+
Sbjct: 1088 RQTVS----LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1143
Query: 829 KTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEK 888
K +DLK +L ++ ++L +Q S + LK + + LE++
Sbjct: 1144 KEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYN 1203
Query: 889 DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAM 948
L L+DL++ LK +++ N + A+++++L E + +
Sbjct: 1204 QLLKQKGQLEDLEK---MLKVEQEKMLLENKNHETVAAEYKKL---CGENDRLNHTYSQL 1257
Query: 949 LKERE---SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISERE 1005
LKE E +D + LL + + E +++ +LK+Q Q + +++S+ +
Sbjct: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317
Query: 1006 KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1065
L E L D ++ +N L E+N E+ + ++ DK+N+ +++++
Sbjct: 1318 ---GNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1374
Query: 1066 EAV 1068
E +
Sbjct: 1375 EKI 1377
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 161 bits (407), Expect = 5e-39
Identities = 245/1159 (21%), Positives = 506/1159 (43%), Gaps = 196/1159 (16%)
Query: 273 TETDKENAEVKFKDFLLSLKTMMFSEDE-ALCVVDLLKEKSGVI--------------QD 317
T+ +E+ E K+ L LK ++ DE + +++L +E+ G+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 318 ALKKS------------SKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
+K++ +K ++ L +L+EK + L K++ + K+L QE M
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 366 KERSNVVITRM-KDRIGTL-EKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLK 423
S+ RM +D + L EK V + + VS + + ++F + R + LK
Sbjct: 299 L--SDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKAR------VEELK 350
Query: 424 QENGILRDAVSNTTNQLESKQ--SAELNKLRQDYARLVN-----ELTEKTGKLQQEEVQK 476
++N +L + + +QLE + S +L++L ++ +L E+ + + EE+ +
Sbjct: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
Query: 477 KNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAE-HEAAQQDL--------QSKFVAKEN 527
+N Q + + WE Q RT+E EA Q+ L S+ + E
Sbjct: 411 ENMTLEMAQKQSMDESLHLGWELEQI---SRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEAL------ 581
E QSL + + + +E ++++ E++ + +++ +I+++ ++L
Sbjct: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
Query: 582 -------KAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKE 634
KAQ+++ + + + K++ ++++ + QT SL +R ++ S E
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQI------KILEQENEHLNQTVSSLR-QRSQI-SAE 579
Query: 635 EELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQH-EI 693
+KDI+ N +L +++ + ++ +++K + K ++ LE +L H E
Sbjct: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
Query: 694 SNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLET 753
N++ + KI N LK +K++ L EQ N + ++ ++ KLK + +
Sbjct: 640 ENELLQKKITN-----LKITCEKIEAL--EQENSE--------LERENRKLKKTLDSFKN 684
Query: 754 GLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSV 813
Q+ + E+E + + EN L + V+ LK + A L E K++ EK+ ++K
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCAS---MKMAQLQLENKELESEKE-QLKKG 740
Query: 814 EELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKE 873
ELL+A K E + Q L +I N +L+K + S K+Q+L++ L+ E
Sbjct: 741 LELLKASFKKTERLEVSYQGL---------DIENQRLQKTLENS-NKKIQQLESELQDLE 790
Query: 874 EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEI 933
+ T++ LEE L + K L+ L++EN+SL+ QE +Q LE
Sbjct: 791 MENQTLQKNLEE----LKISSKRLEQLEKENKSLE---QETSQ--------------LEK 829
Query: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
K+ E E KRL + +++ L + +++ ENK +I K+ +
Sbjct: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
Query: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053
++EL+K + K + L +L S K + NNDL + E + + E++L D+
Sbjct: 890 NKELVKRATIDIKTLVTLREDLVSEKLKTQQM---NNDLEKLTHELEKIGLNKERLLHDE 946
Query: 1054 VNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSE 1113
+ + + +E + + LKK + KE E
Sbjct: 947 -----QSTDDRYKLLESKLESTLKKSL--------------------EIKE--------E 973
Query: 1114 EVKVLEHKLKEADEMHTLLQLECEKYKS---VLAETEGILQKLQRS--VEQEENKWKVKV 1168
++ LE +L+E+ + L+ E + K L + + + +Q S + E+NKW+ +
Sbjct: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1033
Query: 1169 DESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
E+ + + +++ +RL ++ L+ E++ L+ +L++ E + + ++
Sbjct: 1034 QETTRELLKVK----------DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083
Query: 1229 ELKDLLTELQKK---LDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
L+ LQ++ L ++ +N LN L +L +Q+ + + K
Sbjct: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Query: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQ- 1344
++ L+ + ++K E ++ E ++SE E++ +S + T+ + L+ ++
Sbjct: 1144 EREDLKSLYDSLIKDH------EKLELLHERQASEYESL-ISKHGTLKSAHKNLEVEHRD 1196
Query: 1345 ------QLTKEKEHYQVLE 1357
QL K+K + LE
Sbjct: 1197 LEDRYNQLLKQKGQLEDLE 1215
Score = 151 bits (382), Expect = 4e-36
Identities = 234/1138 (20%), Positives = 483/1138 (42%), Gaps = 173/1138 (15%)
Query: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
DQ+EG + K E +KEN ++K K L M D ++ L E++ ++
Sbjct: 365 DQLEGTRARSDKL--HELEKENLQLKAK-----LHDMEMERDMDRKKIEELMEENMTLEM 417
Query: 318 ALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMK 377
A +K S E L +L++ + + + +LT + + E N +T+
Sbjct: 418 A-QKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTV 476
Query: 378 DRIGT--------------LEKEHNVFQNKIHVS---------------------YQETQ 402
+ + T +EKE+ K+ + +E
Sbjct: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
Q++ + +RE E +I L+QEN L VS+ + + A + + ++ L +
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 463 TEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKF 522
E + KL + E +K+ ++ K E R EE+++ + E+E Q+ + +
Sbjct: 597 KETSSKLSKIEFEKRQIKKELEHYK----EKGERAEELENELHHLEKENELLQKKITNLK 652
Query: 523 VAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALK 582
+ E ++++L + ++ ++ ++L + ++S + + ESL+ + + E+N L+
Sbjct: 653 ITCE-KIEALEQENSEL----ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
Query: 583 AQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQN 642
++ K + K Q++ L SE+++L E
Sbjct: 708 RNVESL------------------KCASMKMAQLQLENKELESEKEQLKKGLE------- 742
Query: 643 MNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQ------HEISNK 696
LLKA +K + L E +++Q+++ + KI+ LE +LQ +
Sbjct: 743 ---LLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN 799
Query: 697 MEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLI 756
+EE KI + + + L+ E + L+ S+ +E+ +K +++++++L+ E+ +T L
Sbjct: 800 LEELKISSKRLEQLEKENKSLEQETSQ------LEKDKKQLEKENKRLRQQAEIKDTTLE 853
Query: 757 QVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL 816
+ K + + EN +L+KE+ K V L +E K+++ IK++ L
Sbjct: 854 ENNVK---IGNLEKENKTLSKEIGIYK---ESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 817 LEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQM 876
E V+ K KT Q + +++ L E+ + L K + L + LL+ K E
Sbjct: 908 RED---LVSEKLKT-QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE-- 961
Query: 877 NTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLK 936
+T+K LE KE+ +A +L+A ++E +N + L+
Sbjct: 962 STLKKSLEIKEEKIA--------------ALEARLEESTNYNQQ--------------LR 993
Query: 937 EKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEE 996
++ +K+ LK+R QDE ++ +S + N + S E
Sbjct: 994 QELKTVKKNYEALKQR--------------QDEERMVQSSPPISGEDNKWERESQETTRE 1039
Query: 997 LLKV---ISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDK 1053
LLKV + E E+ + L E +LK ++ +NN+L+ + + T + +
Sbjct: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA---QILALQRQTVSLQEQN 1096
Query: 1054 VNKTSKERQQQVEAVELEAKEV-LKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGS 1112
++ + QVE L ++ L ++ + + E E KE
Sbjct: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE----NESVIKE-------R 1145
Query: 1113 EEVKVL-EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDES 1171
E++K L + +K+ +++ L + + +Y+S++++ G L+ +++E E + + ++
Sbjct: 1146 EDLKSLYDSLIKDHEKLELLHERQASEYESLISK-HGTLKSAHKNLEVEHRDLEDRYNQL 1204
Query: 1172 HKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELK 1231
K Q++ + E E++ ENK+ E + E + L E ++ S + E L+
Sbjct: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1264
Query: 1232 DLLTELQKKLDDSYSEAVRQNEELNLLK---AQLNETLTKLRTEQNERQKVAGDLHKAQQ 1288
L+ L++S E R E + LK QL+ T TKL + ++ G+L + +
Sbjct: 1265 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENR 1324
Query: 1289 S-LELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
L+ IQ+ +++ + T++E + S + E+ LN+ Q ++L + + Q
Sbjct: 1325 HLLDQIQTLMLQ---NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 129 bits (324), Expect = 2e-29
Identities = 236/1142 (20%), Positives = 486/1142 (42%), Gaps = 142/1142 (12%)
Query: 40 KQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHE-SDSESVPRDFKLSDALAVEDDQVA 98
+Q+ E+K K++ E+ + + K +Q N++ SD+ S DAL + +V
Sbjct: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVD 323
Query: 99 PVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEA 158
+ V S +ER + K +EE +KE + + K + + +
Sbjct: 324 KLESEV----SRYKERLHDIEFYKARVEE--LKEDNQVLLETKTMLEDQLEGTRARSDKL 377
Query: 159 AASKKKPGQKKSKNGSDDQD-----KKVETLM-------VPSKRQEALPLHQETKQESGS 206
+K+ Q K+K + + KK+E LM + K+ LH + E S
Sbjct: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
Query: 207 GKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKS 266
+ S QK+ V+E + + + + + V + R +D VEG +
Sbjct: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD-----SVEG---N 489
Query: 267 GTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCV---VDLLKEKSGVIQ--DALKK 321
+K LK E KEN + K +L + + + C DL+KEK+ + + + L++
Sbjct: 490 ASKILKME--KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 322 SSKGELTTLIHQLQEKDKLLAAVKEDAAATKD-RCKQLTQEMMTEKERSNVVITRM---- 376
+S+ ++ L + + ++ ++++++ + + + R K + +E E +++
Sbjct: 548 NSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
Query: 377 -KDRIGTLEKEH--------NVFQNKIHVSYQETQQMQMKFQQVR------EQMEAEIAH 421
+ R E EH +N++H +E + +Q K ++ E +E E +
Sbjct: 608 FEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSE 667
Query: 422 LKQENGILR---DAVSNTTNQLES--KQSAELNKLRQDYARLVNELTEKTGKLQQEEVQK 476
L++EN L+ D+ N T QLES K++++L++ + R V L + K+ Q +++
Sbjct: 668 LERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 477 KNAEQAATQLKVQLQ------------EAERRWEEVQSYIRKRTAEHEAAQ-QDLQSKFV 523
K E QLK L+ E + ++++ ++T E+ + Q L+S+
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 524 AKENEVQSLHSKLTDTLVSKQQLEQ---------RLMQLMESEQKRVNKEESLQMQVQDI 574
E E Q+L L + +S ++LEQ + +E ++K++ KE Q +I
Sbjct: 788 DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEI 847
Query: 575 ----LEQNEA----LKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
LE+N L+ + + +I + V +EL K E K+ +L +
Sbjct: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 627 RDRLTSKEEELKDIQNMNFLLKAEVQKL-----QALANEQAA------AAHELEK-MQQS 674
R+ L S++ + + + N L E++K+ + L +EQ+ +LE +++S
Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKS 967
Query: 675 VYVKDDKIRLLEEQLQHEISNKME---EFKILNDQNKALKSEVQKLQTLVSEQPNKDVVE 731
+ +K++KI LE +L+ + + E K + +ALK + + + S P
Sbjct: 968 LEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN 1027
Query: 732 QMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAK----QN 787
+ E+ QE +L V++ L AT + E A++T+ L + +L+A+ Q
Sbjct: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQR 1087
Query: 788 DQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE------------------K 829
VS ++E + ++ K++ L ++ + N+ K
Sbjct: 1088 QTVS----LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Query: 830 TVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKD 889
+DLK +L ++ ++L +Q S + LK + + LE++
Sbjct: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
Query: 890 LANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAML 949
L L+DL++ LK +++ N + A+++++L E + +L
Sbjct: 1204 LLKQKGQLEDLEK---MLKVEQEKMLLENKNHETVAAEYKKL---CGENDRLNHTYSQLL 1257
Query: 950 KERE---SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREK 1006
KE E +D + LL + + E +++ +LK+Q Q + +++S+ +
Sbjct: 1258 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK- 1316
Query: 1007 EISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVE 1066
L E L D ++ +N L E+N E+ + ++ DK+N+ +++++ E
Sbjct: 1317 --GNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEE 1374
Query: 1067 AV 1068
+
Sbjct: 1375 KI 1376
Score = 92.0 bits (227), Expect = 3e-18
Identities = 169/808 (20%), Positives = 332/808 (41%), Gaps = 113/808 (13%)
Query: 35 DEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVED 94
+E+L K+ K+ +K +A +++N + E +N L ++ F+L ++L E+
Sbjct: 641 NELLQKKITNLKIT---CEKIEALEQENSELERENRKLKKTLDSFKNLTFQL-ESLEKEN 696
Query: 95 DQVAPVPLNVVETSSSVRERKKK------EKKQKPVLEEQVIKESDASKIPGKKVEPVPV 148
Q+ L + S++ K E K+ +EQ+ K + K KK E + V
Sbjct: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
Query: 149 TKQPTPPSEAAASK--KKPGQKKSKNGSDDQD---------KKVETLMVPSKRQEALP-- 195
+ Q K + +K + S+ QD K +E L + SKR E L
Sbjct: 757 SYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKE 816
Query: 196 ---LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVI 252
L QET Q K+ K+ + + + + + N + +E+
Sbjct: 817 NKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV--KIGNLEKENKTLSKEI- 873
Query: 253 DLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKS 312
GI K +LK E +KEN E+ K + +KT++ + DL+ EK
Sbjct: 874 ---------GIYKESCVRLK-ELEKENKEL-VKRATIDIKTLVTLRE------DLVSEKL 916
Query: 313 GVIQDALKKSSKGELTTLIHQLQE----KDKLLAAVKEDAAATKDRCKQLTQEMMTEKER 368
Q +L L H+L++ K++LL D +T DR K L ++ + ++
Sbjct: 917 KTQQ------MNNDLEKLTHELEKIGLNKERLL----HDEQSTDDRYKLLESKLESTLKK 966
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
S + +++I LE ++ S QQ++ + + V++ EA LKQ
Sbjct: 967 SLEI---KEEKIAALEA-------RLEESTNYNQQLRQELKTVKKNYEA----LKQRQDE 1012
Query: 429 LRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV 488
R S+ S E NK ++ EL + +L + E + LK
Sbjct: 1013 ERMVQSSPPI------SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1066
Query: 489 QLQEAERRWEEVQSYI---RKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQ 545
QL++ E + +Q+ I +++T + LQ++ + E +L+S+ T + Q
Sbjct: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
Query: 546 LEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
L + L + + + E L+ +++ +E L+ H + A++ + +
Sbjct: 1127 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLEL----LHERQASEYESLI---SK 1179
Query: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAA 665
H + K ++ L ++L ++ +L+D++ M LK E +K+ A
Sbjct: 1180 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKM---LKVEQEKMLLENKNHETVA 1236
Query: 666 HELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEV--QKLQTLVSE 723
E +K+ ++L H S ++E ++L +K LKS + KL+ E
Sbjct: 1237 AEYKKLCGE-----------NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE 1285
Query: 724 QPNKDVVEQMEKCIQEKDEKLKTVEELLE--TGLIQVATKE--EELNAIRTENSSLTKEV 779
+ EQ ++ + KL ELL G ++ + +++ + +N +L +
Sbjct: 1286 AEFSKLKEQYQQ-LDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE-- 1342
Query: 780 QDLKAKQNDQVSFASLVEELKKVIHEKD 807
Q++++K V +++L ++ +K+
Sbjct: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKE 1370
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 157 bits (398), Expect = 5e-38
Identities = 233/1105 (21%), Positives = 478/1105 (43%), Gaps = 174/1105 (15%)
Query: 337 KDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHV 396
KD L AA AA +D+ +++ E+ + ++ ++ T E+ V + K+ +
Sbjct: 362 KDVLQAA----AAEHQDQGQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRL 417
Query: 397 SYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAV--SNTTNQLESKQSAELNKLRQD 454
Q Q ++E+ E + A L + L+ V S+++ Q + S+E++ L+Q
Sbjct: 418 EGQLEALSLEASQALKEKAELQ-AQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQS 476
Query: 455 YARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAA 514
L +T+ Q ++ KNA A++ LQ AE +++ + + +
Sbjct: 477 CWDLERAMTDL-----QNMLEAKNASLASSNN--DLQVAEEQYQRLMAKV---------- 519
Query: 515 QQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQR---LMQLMESEQKRVNKEESLQM-- 569
+D+Q ++K+N V L ++T QQ++ L +++ Q ++ +S++
Sbjct: 520 -EDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWY 578
Query: 570 QVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDR 629
Q Q L Q ++ Q + H Q+ T A +L E L +Q+ +T+ E+ R
Sbjct: 579 QQQLALAQEARVRLQGEMAHIQVGQMTQAGLL-EHLKLENVSLSQQLTETQHRSMKEKGR 637
Query: 630 LTSKEEELK----------------------DIQNMNFLLKAEVQKLQALANEQAAAAHE 667
+ ++ + ++ D+Q + E ++LQ +A+ A+ +
Sbjct: 638 IAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQ 697
Query: 668 LEKMQQSVYVKDDKIRLLEEQ---LQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSE- 723
LE+++ ++ +D ++ L+++ L +++ E + AL++ +LQ + E
Sbjct: 698 LEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGEL 757
Query: 724 -------------------------QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQV 758
Q K E++++ + +E + E LE ++
Sbjct: 758 QGEAASREDTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLREEL 817
Query: 759 ATKEEELNAIRTENSSLTKEVQDLK-----------AKQNDQVSFASLVEELKKVIHEKD 807
A K ++ ++ E ++L K++Q +K A + D S L+ ELK D
Sbjct: 818 AIKSGQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLD 877
Query: 808 GKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQN 867
++K + + EL++V +++T + E+ L E+ V+ A LQ+
Sbjct: 878 SELKELRQ----ELMQVHGEKRTAE---AELSRLHREVAQVRQHMADLEG------HLQS 924
Query: 868 LLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQ 927
K ++E ++++ +KE+ +A T E NE+LK ++E+ Q K + Q
Sbjct: 925 AQKERDEMETHLQSLQFDKEQMVAVT--------EANEALKKQIEELQQEARKAITEQKQ 976
Query: 928 FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ 987
++ + + + K ++ K E+ + ++ LQ+ + +++ QL+ Q
Sbjct: 977 --KMRRLGSDLTSAQKEMKTKHKAYENAVGILSRRLQEALAAKEAADAELGQLRAQGGSS 1034
Query: 988 ASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTE 1047
SS HE + + +E + AV H + L EK E E +A T
Sbjct: 1035 DSSLALHERIQALEAELQ---------------AVSHSKT----LLEK--ELQEVIALTS 1073
Query: 1048 KMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMA 1107
+ L++ S+E+ ++E E++ KK+ K SN L +K K
Sbjct: 1074 QELEE-----SREKVLELEDELQESRGFRKKI--KRLEESNKKLALELE--HEKGKLTGL 1124
Query: 1108 GTSGS---EEVKVLEHKL--KEADEMHTLLQLEC--EKYKSVLAETEGILQKLQRSVEQE 1160
G S + E +LE L +EAD + LQ++ ++ + + + ++Q LQ S+E+E
Sbjct: 1125 GQSNAALREHNSILETALAKREADLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKE 1184
Query: 1161 ENKWK--------VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEME 1212
+ K KV+ H +S SE + E L+++ ++ L+ E + L++
Sbjct: 1185 KEKVNSLKEQVAAAKVEAGHNRRHFKAASLELSEVKKE-LQAKEHLVQKLQAEADDLQIR 1243
Query: 1213 LEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLR-- 1270
K E + + E+ E + L LQK+LD+ S+ N+E+ LK ++++ +++
Sbjct: 1244 EGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSL 1303
Query: 1271 ------TEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETM 1324
TEQ R+++ G QQ L+ ++S++ A D ++ + + + SE +
Sbjct: 1304 KQQLDLTEQQGRKELEG----LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNN 1359
Query: 1325 SVSLNQTVTQLQQLLQAVNQQLTKE 1349
+L Q QL+ L+ + KE
Sbjct: 1360 MKTLLQQNQQLKLDLRRGAAKTRKE 1384
Score = 83.6 bits (205), Expect = 1e-15
Identities = 114/538 (21%), Positives = 218/538 (40%), Gaps = 64/538 (11%)
Query: 856 LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVA 915
LS T Q+ ++ G+E +T+ K+ A + QE N +++ +
Sbjct: 332 LSKTVGTQDTPYMVNGQEIPADTLGQFPSIKDVLQAAAAEHQDQGQEVNGEVRSRRDSIC 391
Query: 916 QHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKS 975
E+S+A EE+ VLKEK +LEA+ E L K +L + + ++
Sbjct: 392 SSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQA 451
Query: 976 QIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK 1035
Q+E +Q S + L + + E+ ++ L N L++ ++ NNDL+
Sbjct: 452 QVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASL---ASSNNDLQVA 508
Query: 1036 NWEAMEALASTEKMLQDKVNKTSKER---------QQQVEAVELEAKEVLKKL-FPKVSV 1085
+ +A E M + ++K + Q Q++ V+LE + KL + +
Sbjct: 509 EEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQAEI 568
Query: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGS---------EEVKVLEH-KLKEADEMHTLLQLE 1135
S S +W A+E G + +LEH KL+ L + +
Sbjct: 569 SSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLENVSLSQQLTETQ 628
Query: 1136 CEKYKS---VLAETEGI-------------LQKLQRSVEQEENKWKVKVDESHKTIKQMQ 1179
K + A+ +GI +Q+ + VE++ + + + + +++M
Sbjct: 629 HRSMKEKGRIAAQLQGIEADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMA 688
Query: 1180 SSFTSSEQELERLR----SENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLT 1235
S S EQ+LE+++ ++ +E L++E L +L + + + L+
Sbjct: 689 DSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYD 748
Query: 1236 ELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQS 1295
ELQ +L + EA + + + LL QNE+ + L A+ E +
Sbjct: 749 ELQARLGELQGEAASREDTICLL--------------QNEKIILEAALQAAKSGKEELD- 793
Query: 1296 KIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQLTKEKEHY 1353
G + E ++ + ET +E +++ Q V LQQ A+ +Q+ K KE +
Sbjct: 794 -----RGARRLEEGTEETSETLEKLREELAIKSGQ-VEHLQQETAALKKQMQKIKEQF 845
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 156 bits (395), Expect = 1e-37
Identities = 226/1110 (20%), Positives = 476/1110 (42%), Gaps = 173/1110 (15%)
Query: 345 KEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTL----EKEHNVFQNKIHVS--- 397
KE+ A T+ + K+L ++M+T + N + +++ L E+ + + KI +
Sbjct: 864 KEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTKIQLEAKI 923
Query: 398 ------YQETQQMQMKFQQVREQMEAEIAHLK--------------QENGILRDAVSNTT 437
++ +++ + + ++E E + LK +E + V N T
Sbjct: 924 KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 983
Query: 438 NQL------------ESKQSAELNKLRQDYARL----VNELTEKTGKLQQEEVQKKNAEQ 481
++ E K E ++ D ++ VN LT+ KL+Q+ + + +
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLE 1043
Query: 482 AATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLV 541
+L + L+ A+R+ E ++ T + E +Q L K KE E+ +L K+ D
Sbjct: 1044 QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQA 1103
Query: 542 SKQQLEQRLMQLM--------ESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIA 593
QL++++ +L E E +R ++ ++ + Q D+ + E + ++++ +
Sbjct: 1104 LAIQLQKKIKELQARIEELEEEIEAERASRAKA-EKQRSDLSRELEEISERLEEAGGATS 1162
Query: 594 AQTSASVLAE-ELHKVIAEKDKQIKQTEDSLASER----DRLTSKEEELKDIQNMNFLLK 648
AQ + E E K+ + ++ Q E + A+ R D + E++ +Q + L+
Sbjct: 1163 AQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLE 1222
Query: 649 AEVQKLQALANEQAA-------AAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFK 701
E +L+ N+ A+ A EKM +++ + +I+ EE+ Q I+ +
Sbjct: 1223 KEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKA 1282
Query: 702 ILNDQNKALKSEVQKLQTLVSE-----QPNKDVVEQMEKCIQEKDEKLKTVEELLETG-- 754
L+ ++ ++ + +VS+ Q +E++++ ++E+ + T+ L++
Sbjct: 1283 RLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARH 1342
Query: 755 ----LIQVATKEEELNA-IRTENSSLTKEVQDLKAK-QNDQVSFASLVEELKKVIHEKDG 808
L + +E+E A ++ S EV + K + D + +EE KK + +
Sbjct: 1343 DCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ--- 1399
Query: 809 KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN-----VQLEKAQQ------LS 857
+++ EE +EA K A+ EKT Q L+ E++ L ++ + L+K Q+
Sbjct: 1400 RLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAE 1459
Query: 858 ITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQH 917
K +E Q L+ +++ ++ L + + + L+ L+ EN++L+ QE++
Sbjct: 1460 WKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQ---QEISDL 1516
Query: 918 NLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 977
+ A ELE V K+ ++E L+ L+E E+ L + + +Q E KS+I
Sbjct: 1517 TEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 978 EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLRE--- 1034
++ + ++ + L+V+ + + E+ S DA+ ++K DL E
Sbjct: 1577 DRKIAEKDEELDQLKRNH--LRVVESMQSTLDA---EIRSRNDALRIKKKMEGDLNEMEI 1631
Query: 1035 ----KNWEAMEALAS----------TEKMLQDKVNKTSKERQQ-----------QVEAVE 1069
N +A EAL + T+ L D + ++Q Q E E
Sbjct: 1632 QLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEE 1691
Query: 1070 LEAKEVLKKLFPKVSVPSNLSYGE---WLH-------GFEKKAKECMAGTSGS-----EE 1114
L A + K++ L E LH +KK + ++ G +E
Sbjct: 1692 LRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQE 1751
Query: 1115 VKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESH-- 1172
+ E K K+A ++ E +K + +T L+++++++EQ ++++DE+
Sbjct: 1752 ARNAEEKAKKAITDAAMMAEELKKEQ----DTSAHLERMKKNMEQTVKDLQLRLDEAEQL 1807
Query: 1173 ------KTIKQMQSSFTSSEQELERLRSENKD-IENLRREREHLEMELEKAEMERSTYVT 1225
K I+++++ E E+E + N + ++ LR+ ++ + E +R
Sbjct: 1808 ALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK---- 1863
Query: 1226 EVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHK 1285
+ L+DL+ +LQ K+ +Y + EE Q N L K R Q+E L +
Sbjct: 1864 NILRLQDLVDKLQTKV-KAYKRQAEEAEE------QSNVNLAKFRKLQHE-------LEE 1909
Query: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPE 1315
A++ ++ +S++ K + + +S E
Sbjct: 1910 AKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 136 bits (342), Expect = 2e-31
Identities = 209/905 (23%), Positives = 378/905 (41%), Gaps = 125/905 (13%)
Query: 543 KQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLA 602
K++ E+ +L ++E KR EE + +Q E+N+ L+ Q+Q ++ A A
Sbjct: 857 KEEFEKTKEELAKTEAKRKELEEKMVTLMQ---EKND-LQLQVQ---AEADALADAEERC 909
Query: 603 EELHKVIAEKDKQIKQTEDSLASERD---RLTSKEEEL--------KDIQNMNFLLKAEV 651
++L K + + +IK+ + E + LT+K+ +L KDI ++ L
Sbjct: 910 DQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 969
Query: 652 QKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISN-KMEEFKILNDQNKAL 710
++ A N+ E+ + +++ + + L+E Q + + +MEE K+ N KA
Sbjct: 970 KEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKV-NTLTKAK 1028
Query: 711 KSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT 770
Q++ L +EQ +K + + + +E L+ L Q +T + E N +
Sbjct: 1029 TKLEQQVDDLEGS------LEQEKKLCMDLERAKRKLEGDLK--LAQESTMDTE-NDKQQ 1079
Query: 771 ENSSLTK---EVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK 827
N L K E+ +L+ K D+ + A +L+K I E +I+ +EE +EAE A
Sbjct: 1080 LNEKLKKKEFEMSNLQGKIEDEQALAI---QLQKKIKELQARIEELEEEIEAERASRAKA 1136
Query: 828 EKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQ-ELQNLLKGKEE---QMNTMKAVL 883
EK DL +E++ + E + + Q+ + K + E Q + + EE Q A L
Sbjct: 1137 EKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAAL 1196
Query: 884 EEKEKD-LANTGKWL-------QDLQEENESLKAHVQEVAQHNLKEASSASQFEEL---- 931
+K D +A G+ + Q L++E LK + ++A + + + + FE++
Sbjct: 1197 RKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTL 1256
Query: 932 -----EIVLKEKE-----NELKRLEAMLK----ERESDLSSKTQLLQDVQDENKLFKSQI 977
EI KE+E NEL +A L E L K ++ + + F QI
Sbjct: 1257 EDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQI 1316
Query: 978 EQLKQQNYQQ--ASSFPPHE--------ELLKVISEREKEISG-LWNELDSLKDAVEHQR 1026
E+LK+Q ++ A S H +LL+ E E+E L + V R
Sbjct: 1317 EELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWR 1376
Query: 1027 KK-NNDLREKNWEAMEALASTEKMLQD-------------KVNKTSKERQQQVE--AVEL 1070
K D ++ E EA + LQD + KT + Q +VE +++
Sbjct: 1377 TKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDV 1436
Query: 1071 EAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEA----- 1125
E K + EW +E+ E A S + K+K A
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESL 1496
Query: 1126 DEMHTLLQLECEKYKSVLAETEGI---------LQKLQRSVEQEENKWKVKVDESHKTIK 1176
D + TL + + + TE I L+K+++ ++ E+++ + ++E+ +++
Sbjct: 1497 DHLETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLE 1556
Query: 1177 QMQSSFTSSEQELERLRSE------NKDIENLRREREHLEMELEKAEMERSTYVTEVREL 1230
+ + EL +++SE KD E + +R HL + E +ST E+R
Sbjct: 1557 HEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRV----VESMQSTLDAEIRSR 1612
Query: 1231 KDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQ---NERQKVAGDLHKAQ 1287
D L ++KK++ +E +LN Q E L LR Q + Q D + Q
Sbjct: 1613 NDAL-RIKKKMEGDLNE---MEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQ 1668
Query: 1288 QSLELIQSKIVKAAGDTTVIENSDVSPETESSEK-ETMSVSLNQTVTQLQQLLQAVNQQL 1346
L+ Q +V+ + E ++ E +E+ M+ ++ QLL N L
Sbjct: 1669 DDLK-EQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSL 1727
Query: 1347 TKEKE 1351
K+
Sbjct: 1728 INTKK 1732
Score = 94.0 bits (232), Expect = 9e-19
Identities = 181/904 (20%), Positives = 376/904 (41%), Gaps = 122/904 (13%)
Query: 30 KETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDA 89
++ L ++ K K Q I ++ +AE+ K E Q +L E R + A
Sbjct: 1101 EQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGA 1160
Query: 90 LAVEDDQVAPVPLNVVETSSSVRERKKKE---KKQKPVLEEQVIK-ESDASKIPGKKVEP 145
TS+ + KK+E +K + LEE ++ E+ A+ + K +
Sbjct: 1161 -----------------TSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADS 1203
Query: 146 VPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESG 205
V + + K + + + K +D +ET+ SK + T ++
Sbjct: 1204 VAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETV---SKAKANFEKMCRTLEDQL 1260
Query: 206 SGKKKASSKKQKTEN-VFVDEPLIHATT--YIPLMDNADSSPVVDKREVIDLLKPDQVEG 262
S K ++Q+ N + + +H + + +D D+ +V + Q+E
Sbjct: 1261 SEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDA--MVSQLSRGKQAFTQQIEE 1318
Query: 263 IQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVD--LLKEKSGVIQ---- 316
+++ ++ K ++ +A + L+ E EA + + K S V Q
Sbjct: 1319 LKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTK 1378
Query: 317 ---DALKKSSKGELTT--LIHQLQEKDKLLAAVKEDAAA---TKDRCKQLTQEMMTEKER 368
DA++++ + E L +LQ+ ++ + AV A+ TK R + +++M + ER
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 369 SNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGI 428
SN + + +K ++ K Y+ETQ Q+ + E+ +K
Sbjct: 1439 SNAACIALDKKQRNFDKVLAEWKQK----YEETQAELEASQKESRSLSTELFKVK----- 1489
Query: 429 LRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKV 488
+A + + LE+ + N L+Q+ + L ++ E + + E KK + ++L+
Sbjct: 1490 --NAYEESLDHLETLKRENKN-LQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQT 1546
Query: 489 QLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQ 548
L+EAE E + I + E + ++ K K+ E+ QL++
Sbjct: 1547 SLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD--------------QLKR 1592
Query: 549 RLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQI--AAQTSASVLAEELH 606
++++ES Q ++ E + D L + ++ + + Q+ A + +A L +
Sbjct: 1593 NHLRVVESMQSTLDAEIRSR---NDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649
Query: 607 KVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQA---------- 656
KD Q+ +D++ + D +E+L ++ L++AEV++L+A
Sbjct: 1650 TQGILKDTQL-HLDDAIRGQDDL----KEQLAMVERRANLMQAEVEELRASLERTERGRK 1704
Query: 657 LANEQAAAAHE----LEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ-NKALK 711
+A ++ A E L S+ K+ Q+Q E+ + ++E + ++ KA+
Sbjct: 1705 MAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAIT 1764
Query: 712 SEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTE 771
+ L EQ +E+M+K +++ TV++L Q+ E E A++
Sbjct: 1765 DAAMMAEELKKEQDTSAHLERMKKNMEQ------TVKDL------QLRLDEAEQLALKGG 1812
Query: 772 NSSLTK---EVQDLKAK-QNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANK 827
+ K V++L+++ +++Q V+ L+K HE+ ++K + E + +
Sbjct: 1813 KKQIQKLEARVRELESEVESEQKHNVEAVKGLRK--HER--RVKELTYQTEEDRKNILRL 1868
Query: 828 EKTVQDLKQEIKALK------EEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKA 881
+ V L+ ++KA K EE NV L K ++L +++E + E Q+N ++
Sbjct: 1869 QDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQ--HELEEAKERADIAESQVNKLRV 1926
Query: 882 VLEE 885
E
Sbjct: 1927 KSRE 1930
Score = 52.4 bits (124), Expect = 3e-06
Identities = 108/643 (16%), Positives = 264/643 (41%), Gaps = 85/643 (13%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTD----KKKAEKKKNKKKEIQNGNLHES--------- 75
+K L +E AK L + D +++ E+++ K E+Q G +
Sbjct: 1319 LKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTK 1378
Query: 76 -DSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVI---- 130
+++++ R +L +A ++ +V +S +K +++ + +E+ +I
Sbjct: 1379 YETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVER 1438
Query: 131 ----------KESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK 180
K+ + K+ + + T+ S+ + K KN ++
Sbjct: 1439 SNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDH 1498
Query: 181 VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPL-MDN 239
+ETL +K + + T+Q + GK +K K + L H + + ++
Sbjct: 1499 LETLKRENKNLQQ-EISDLTEQIAEGGKHIHELEKVKKQ-------LDHEKSELQTSLEE 1550
Query: 240 ADSSPVVDKREVIDL-LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSE 298
A++S ++ +++ + L+ +QV KS + E D+E ++K ++ L +++M +
Sbjct: 1551 AEASLEHEEGKILRIQLELNQV----KSEIDRKIAEKDEELDQLK-RNHLRVVESMQSTL 1605
Query: 299 DEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQ- 357
D + + ++ ++ +KK +G+L + QL ++ A + T+ K
Sbjct: 1606 DAEI------RSRNDALR--IKKKMEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDT 1657
Query: 358 -------------LTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQM 404
L +++ + R+N++ +++ +LE+ + ++++
Sbjct: 1658 QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQELLDASERV 1717
Query: 405 QMKFQQ------VREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARL 458
Q+ Q ++++E +I+ ++ E + D V N E + A D A +
Sbjct: 1718 QLLHTQNTSLINTKKKLETDISQIQGE---MEDIVQEARNAEEKAKKAIT-----DAAMM 1769
Query: 459 VNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRW-----EEVQSYIRKRTAEHEA 513
EL ++ E KKN EQ L+++L EAE+ +++Q + R E E+
Sbjct: 1770 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQK-LEARVRELES 1828
Query: 514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQD 573
+ Q V ++ ++ + ++ + +++L + K K ++ + Q ++
Sbjct: 1829 EVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEE 1888
Query: 574 ILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQI 616
EQ+ A+ ++ ++ + +AE + K +++
Sbjct: 1889 AEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREV 1931
Score = 43.9 bits (102), Expect = 0.001
Identities = 44/214 (20%), Positives = 97/214 (45%), Gaps = 26/214 (12%)
Query: 1166 VKVDESHKTIKQMQSSFTSSEQELERLRSENKDIEN----LRREREHLEMELEKAEMERS 1221
+K E+ K + M+ F +++EL + ++ K++E L +E+ L+++++ AE +
Sbjct: 844 LKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ-AEADA- 901
Query: 1222 TYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAG 1281
+ + E D L + + +L+ E + E+ + A+L KL E +E +K
Sbjct: 902 --LADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDID 959
Query: 1282 DLH----KAQQSLELIQSKIVK-----AAGDTTVIENSDVSPETESSEKETMSV------ 1326
DL K ++ ++K+ A D T+ + + + + ++T+
Sbjct: 960 DLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEED 1019
Query: 1327 ---SLNQTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
+L + T+L+Q + + L +EK+ LE
Sbjct: 1020 KVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLE 1053
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 152 bits (385), Expect = 2e-36
Identities = 260/1326 (19%), Positives = 571/1326 (43%), Gaps = 180/1326 (13%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSD 88
+++ + +EV+ +RE+ + + K+ +++ + ++ + ++ +
Sbjct: 1393 LQQRMQEEVV---RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE---RS 1446
Query: 89 ALAVEDD-QVAPVPLNVVETS--------SSVRERKKKEKKQKPVLEEQV--IKESDASK 137
L +E++ +V + L E ++R R ++ + QK +E+ ++ +
Sbjct: 1447 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1506
Query: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQ--KKSKNGSDDQDKKVETLMVPSKRQEALP 195
K+ V + + +EAA K++ Q ++ + +++ ++++ V RQ +
Sbjct: 1507 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1566
Query: 196 LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL 255
L + + K +S +KT + H V RE +
Sbjct: 1567 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-------------VAQLREEAERR 1613
Query: 256 KPDQVEGIQKSGTKKLKTETDKENAEVKFKDFL-LSLKTMMFSEDEALCVVDLLKEKSGV 314
Q E + + + E + E ++K + L L L+ ++ ++L + K+K
Sbjct: 1614 AQQQAEAERA----REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1669
Query: 315 IQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVIT 374
++A ++ E +L E++ L ++ A T + QE++ R
Sbjct: 1670 EREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELI----RLRAETE 1723
Query: 375 RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
+ + + LE+E Q + + Q+ Q+++ + +VR +ME +A + R
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1783
Query: 435 NTTNQLESK---------QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA-- 483
+ +LE++ ++A L L ++ A+ +L E+ Q+ E ++ AE+ A
Sbjct: 1784 KSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAERVLAEKLAAI 1842
Query: 484 -------TQLKVQLQEAE------RRWEEVQSYIRKRTAEHEAAQQ-DLQSKFV----AK 525
T+ ++ L+E E RR E +++ R+R E A + D++ + A
Sbjct: 1843 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
++E++ + DTL ++Q+E+ ++ L S +K + L++++ I E
Sbjct: 1903 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE------ 1956
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED----SLASERDRLTSKEEELKDIQ 641
+ ++ A + A ++ AE++++ ++ E+ SLA+E + ++ L++++
Sbjct: 1957 ----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHEL--EKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
+ ++ E ++L+ A +++A +L E Q+ + ++ +Q + E+ +++
Sbjct: 2013 RLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 700 FKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ----EKDEKLKTVEELLETGL 755
+ + DQ L+ E + + E V + E E+ E+LK E
Sbjct: 2072 EQSVLDQ---LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128
Query: 756 IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
Q E+L + ++ + + +Q + +E+ KK + + VE+
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2186
Query: 816 LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
L L++ + L +E++ LK E E A+Q S+V+E ++ + E+
Sbjct: 2187 ELTTLRLQLEETDHQKNLLDEELQRLKAEA----TEAARQ---RSQVEEELFSVRVQMEE 2239
Query: 876 MNTMKAVLEEKEK-----DLANTGKWLQDLQEENESLKAHVQEVAQHNL--KEASSASQF 928
++ +KA +E + + D NT ++LQ EE E +K +E A+ ++ +EA+ Q
Sbjct: 2240 LSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEEAARLSVAAQEAARLRQL 2296
Query: 929 EELEIVLKEKENELKRLEAMLKERESD-LSSKTQLLQD----VQDENKLFKSQIEQLKQQ 983
E ++ + E E M +E+ L ++ +LLQ Q++ + + EQ+ QQ
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2356
Query: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH----QRKKNND---LREKN 1036
++ F + L+ +R+ E+S E + LK V Q + D R++
Sbjct: 2357 LAEETQGF---QRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQA 2410
Query: 1037 WEAMEALASTEKMLQDKVN--KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW 1094
E E L TE Q+KV +T + ++QQ + +E + +L
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL--------------- 2455
Query: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD--EMHTLLQLECEKYKSVLAETEGILQK 1152
++ KE + +E K+L+ K +E + LLQ +S L+E + +LQ+
Sbjct: 2456 -----EREKEKL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505
Query: 1153 LQRSVEQEENK----WKVKVDESHKTIKQMQSSFTSSEQELERL--------RSENKDIE 1200
+R +EQE+ K ++ +V ++ + ++ Q EQE +RL R +++ E
Sbjct: 2506 -ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2564
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
+RR++E EL++ E +R + E L E + L++ + A+ +EE+ +
Sbjct: 2565 GVRRKQE----ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2620
Query: 1261 QLNETL 1266
+TL
Sbjct: 2621 AATKTL 2626
Score = 138 bits (347), Expect = 4e-32
Identities = 269/1431 (18%), Positives = 598/1431 (41%), Gaps = 233/1431 (16%)
Query: 39 AKQKREQ-KLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
A++++EQ + +P + E+ + ++ ++ H E R F A++D ++
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR-FAKQYINAIKDYEL 1284
Query: 98 APVPLNV-VETSSSVRERKKKEKKQKPVLEEQV---IKESDASKIPGKKVEPVPVTKQPT 153
V +E +S ++ K + + V++E V S+ + + + ++ + T +
Sbjct: 1285 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1344
Query: 154 PPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASS 213
E A +++ ++++++ E K+++ H + K ++ K+
Sbjct: 1345 EEEERLAEQQR---------AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1395
Query: 214 KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273
+ Q+ E V +E + A KR + ++++ +++S +++
Sbjct: 1396 RMQE-EVVRREEAAVDAQQ--------------QKRSI-----QEELQQLRQSSEAEIQA 1435
Query: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
+ + A + + +E + VV L E + + + ++GEL L +
Sbjct: 1436 KARQAEAAERSR----------LRIEEEIRVVRLQLEAT----ERQRGGAEGELQALRAR 1481
Query: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVI-TRMKDRIGTLEKEHNVFQN 392
+E + A K A +R ++ Q+ K ++ V + +R+K ++ Q
Sbjct: 1482 AEEAE----AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ- 1536
Query: 393 KIHVSYQETQQMQMKFQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKL 451
++++++ ++ ++ +AE+ +Q L A + +L+SK+++ K
Sbjct: 1537 -------ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1589
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE-EVQSYIRKRTAE 510
Q R + E +L++E ++ + A + + + + RW+ + +R R
Sbjct: 1590 AQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 511 HEAAQQDLQSKFVAK---------------------------ENEVQSLHSKLTDTLVSK 543
E AQQ ++ A+ E E++ T +
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1708
Query: 544 QQLEQRLMQLM----ESEQKRVNKEES---LQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
EQ L++L + EQ+R EE LQ + ++ + L+A++ + +++
Sbjct: 1709 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1768
Query: 597 SASVLAEELHKVIAEKDKQIKQTE----DSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
++ AEE + +EK KQ + E LA E RL + EE K + + AE
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL-----AEED 1823
Query: 653 KLQALANEQAAAAHELEKMQQSVYVKDD-KIRLLEEQLQHEISNKMEEFKI-----LNDQ 706
+ A + A +L + ++ +K + +I L E++ ++E ++ E + L +Q
Sbjct: 1824 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1883
Query: 707 NKALKSEVQKLQTLVSE------QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT 760
K+++++ + + + K +VE + ++ +E++ ++ E A
Sbjct: 1884 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1943
Query: 761 KEEELNAIRT--ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE--- 815
E EL IR+ E++ +KE +L+A + Q+ A+ E ++ E+ K + EE
Sbjct: 1944 LELELGRIRSNAEDTLRSKEQAELEAARQRQL--AAEEERRRREAEERVQKSLAAEEEAA 2001
Query: 816 ------LLEAELLKV------ANKEKTVQDLKQEIKALKEEIGNVQL---EKAQQLSITS 860
L E E LK +E+ Q+ ++++ L +E +L EKA ++
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQ 2060
Query: 861 KVQELQNLLKGKEEQMNTMKAVLE--------------EKEKDLANTGKWLQDLQ----- 901
K QELQ L+ ++ ++ ++ E + E++ A + + +++ +
Sbjct: 2061 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2120
Query: 902 -EENESLKAHVQEVAQHNLKEA--SSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 958
EE +A Q A+ KEA +A + + + L++K+ +E K E L
Sbjct: 2121 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2180
Query: 959 KTQL----------LQDVQDENKLFKSQIEQLKQQNYQQA-SSFPPHEELLKVISEREKE 1007
K Q+ L++ + L ++++LK + + A EEL V + E
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-- 2238
Query: 1008 ISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1067
EL LK +E + + LR+K+ +T++ LQ++ K K+ ++
Sbjct: 2239 ------ELSKLKARIEAENRA-LILRDKD--------NTQRFLQEEAEK-MKQVAEEAAR 2282
Query: 1068 VELEAKEVLK-KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126
+ + A+E + + + + + E + ++K + T E ++L+ + + A
Sbjct: 2283 LSVAAQEAARLRQLAEEDLAQQRALAEKM--LKEKMQAVQEATRLKAEAELLQQQKELAQ 2340
Query: 1127 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1186
E LQ + E+ LAE Q QR++E E + ++++ + +K + + ++
Sbjct: 2341 EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2396
Query: 1187 QELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYS 1246
E +D + R++ E + +L + E+ VT V+ L E+Q++ D +
Sbjct: 2397 ARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDA 2445
Query: 1247 EAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1306
E +L E + +L E+ + Q+ A L + ++ +Q + + +T
Sbjct: 2446 E-------------RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--QLLQETQA 2490
Query: 1307 IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ---AVNQQLTKEKEHYQ 1354
++ S +S + ++E + Q +L+QL Q A QQL +E++ Q
Sbjct: 2491 LQQSFLSEKDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538
Score = 135 bits (341), Expect = 2e-31
Identities = 235/1151 (20%), Positives = 482/1151 (41%), Gaps = 151/1151 (13%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAV--EDDQVAPVPLNVVETSSSV 111
+++AE++ ++ E + E++ E K ++AL + + ++VA +
Sbjct: 1607 REEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1665
Query: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
+E ++E +++ EEQ +++ + ++ +++E + T AA +
Sbjct: 1666 KEEAEREARRRGKAEEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQ--------- 1713
Query: 172 NGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHAT 231
E + + ++ ++ Q ++E +++A++ QK + + + + A
Sbjct: 1714 ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1763
Query: 232 TYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDK------ENAEVKFK 285
+ L A + ++ + ++L+ E + E A ++
Sbjct: 1764 MEVLLASKARAE--------------EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1809
Query: 286 DFLLSLKTMMFSEDEALCVVD---LLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLA 342
+ + ED A + +L EK I +A + ++ E+ + + + +++ L
Sbjct: 1810 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA--LKEKEAENERLR 1867
Query: 343 AVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ 402
+ ED A + R ++ + + E + + D LE++ + ++ + Q +
Sbjct: 1868 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEE 1925
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
++ + + E+ A A L+ E G +R SN + L SK+ AEL RQ R +
Sbjct: 1926 EI-LALKASFEKAAAGKAELELELGRIR---SNAEDTLRSKEQAELEAARQ---RQLAAE 1978
Query: 463 TEKTGKLQQEEVQKKNA--EQAATQLKVQLQEAERRWEEVQSY--IRKRTAEH------- 511
E+ + +E VQK A E+AA Q K L+E ER +V+ +R+R +
Sbjct: 1979 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2038
Query: 512 --EAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
EAAQ+ LQ++ A VQ +L TL +Q + +L E+ ++ + E ++
Sbjct: 2039 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 570 QVQDILEQN----EALKAQIQQFHSQIAAQTSASVLAEELHKVI---------------- 609
Q + Q+ E + Q Q A+ A AE+L K
Sbjct: 2099 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2158
Query: 610 ------AEKDKQIKQTEDSL---ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
AE +K K E +L A LT+ +L++ + LL E+Q+L+A A E
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
A ++E+ SV V+ +++ L+ +++ E N+ + ++ + L+ E +K++ +
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILRDKDNTQRFLQEEAEKMKQV 2276
Query: 721 VSEQPNKDV-VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSL--TK 777
E V ++ + Q +E L L E L + +E ++ E L K
Sbjct: 2277 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2336
Query: 778 EVQDLKAK--QNDQVSFA-SLVEELKKVIHEKDG-KIKSVEELLEAELLKV--------- 824
E+ +A+ Q D+ A L EE + + + + +E EAE LK+
Sbjct: 2337 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2396
Query: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
A E+ Q +++ + + E++ +L +++++ ++ + E++ A LE
Sbjct: 2397 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2456
Query: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKR 944
+++ L K LQ EE +Q V Q L + + A Q + L EK++ L+R
Sbjct: 2457 REKEKLQQEAKLLQLKSEE-------MQTVQQEQLLQETQALQ----QSFLSEKDSLLQR 2505
Query: 945 LEAMLKERESDLSSKTQLLQD-VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISE 1003
E +++ ++ L QL QD V +L + Q Q +Q ++ EE + E
Sbjct: 2506 -ERFIEQEKAKLE---QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2561
Query: 1004 REKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQ 1063
E+ + EL L+ + +R++ L E+N E L L ++ ++ + +
Sbjct: 2562 AEEGVRRKQEELQQLE---QQRRQQEELLAEENQRLREQL-----QLLEEQHRAALAHSE 2613
Query: 1064 QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM------AGTSGSEEVKV 1117
+V A ++ A + L + P+ + E H F+ ++ AG +EE++
Sbjct: 2614 EVTASQVAATKTLPNGRDALDGPA--AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Query: 1118 LEHKLKEADEM 1128
L DE+
Sbjct: 2672 LAQGHTTVDEL 2682
Score = 126 bits (317), Expect = 1e-28
Identities = 225/1168 (19%), Positives = 479/1168 (41%), Gaps = 113/1168 (9%)
Query: 238 DNADSSPVVDKREVIDLLKPDQ--VEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMM 295
+ + P+ D + V + L+ +Q +E I++ G K + + + KD+ L L T
Sbjct: 1231 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1290
Query: 296 FSEDEALCVVDLLKEKSG---VIQDALK-KSSKGELTTLIHQLQE--KDKLLAAVKEDAA 349
+ K +SG VIQ+ + ++ ELTTL Q + + L +E+
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 350 ATKDRCKQLTQ--EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
A + R ++ + E+ E+ + E+E Q ++ ++ +
Sbjct: 1351 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1410
Query: 408 FQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTG 467
QQ + ++ E+ L+Q S Q +++Q+ + R R+ E+
Sbjct: 1411 AQQQKRSIQEELQQLRQS--------SEAEIQAKARQAEAAERSR---LRIEEEIRVVRL 1459
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
+L+ E Q+ AE L+ + +EAE + + Q + + + Q + V +
Sbjct: 1460 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1519
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE-QNEALKAQIQ 586
V++ + + Q LE+ +Q E+E++ E QVQ LE + +A++Q
Sbjct: 1520 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1579
Query: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
+ A +T A+ ++ +++ ++A R+ + ++ + +
Sbjct: 1580 SKRASFAEKT-------------AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1626
Query: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
+ E+++ Q ANE + E++ Q + + +E+ + E + + + Q
Sbjct: 1627 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1686
Query: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKC-IQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ + E++K + L + + + E ++ + E+ + +LLE ++A + E
Sbjct: 1687 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE---ELARLQREA 1743
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE-----ELLE-- 818
A + L E+ ++A+ ++ + EE + EK + E EL E
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 819 AELLKVANKEKTVQDLKQEIKA---------LKEEIGNV----QLEKAQQLSITSKVQEL 865
A L +A + K + L +E A L E++ + +L+ ++++ K E
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
+ L + E++ + + E+ + A+ + L L++ ++S + + + L++
Sbjct: 1864 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1923
Query: 926 SQ--------FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 977
+ FE+ E E EL R+ + E L SK Q + + +L +
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1980
Query: 978 EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK-N 1036
+ ++ + S EE + R+++ + E++ LK VE R+ LRE+
Sbjct: 1981 RRRREAEERVQKSLAAEEE-----AARQRKAA--LEEVERLKAKVEEARR----LRERAE 2029
Query: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNL-SYGEWL 1095
E+ L ++ Q ++ K V+ E E ++ L++ + SV L E
Sbjct: 2030 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ---EQSVLDQLRGEAEAA 2086
Query: 1096 HGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1155
++A+E A E +++EA+ L+ E+ A+ + +KL++
Sbjct: 2087 RRAAEEAEE--ARVQAEREAAQSRRQVEEAER----LKQSAEEQAQARAQAQAAAEKLRK 2140
Query: 1156 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1215
EQE + + ++Q Q +++ E+E+ K E R++ +E EL
Sbjct: 2141 EAEQEAAR---RAQAEQAALRQKQ----AADAEMEK---HKKFAEQTLRQKAQVEQELTT 2190
Query: 1216 AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ----NEELNLLKAQLNE-TLTKLR 1270
++ + E K+LL E ++L +EA RQ EEL ++ Q+ E + K R
Sbjct: 2191 LRLQ----LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2246
Query: 1271 TEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE-NSDVSPETESSEKETMSVSLN 1329
E R + D Q+ L+ K+ + A + + + + +E ++
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306
Query: 1330 QTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
L++ +QAV Q+ T+ K ++L+
Sbjct: 2307 LAEKMLKEKMQAV-QEATRLKAEAELLQ 2333
Score = 121 bits (304), Expect = 4e-27
Identities = 224/1057 (21%), Positives = 432/1057 (40%), Gaps = 167/1057 (15%)
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDA--VSNTTNQLESKQSAELNKLRQDYAR 457
E + + +++R Q EA+ LR A V Q ++ E+ + R+ A+
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ----------LQEAERRWEEVQSY---- 503
L L L Q +V+++ EQ QL+ LQ+A RR E++Q+
Sbjct: 1184 L---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 504 ---IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQ-QLEQRLMQL--MESE 557
+R++ + +A ++++ + K E Q + + + + QL QL + S
Sbjct: 1241 SQAVREQLRQEQALLEEIE-RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1299
Query: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
K+ + + +Q+ ++ ++ +S++ TS + + + + + +++ +
Sbjct: 1300 AKKPKVQSGSESVIQEYVD--------LRTHYSELTTLTSQYI--KFISETLRRMEEEER 1349
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E A ER+RL E L E Q+ A A+ QA A E E +
Sbjct: 1350 LAEQQRAEERERLAEVEAAL------------EKQRQLAEAHAQAKAQAEREAKE----- 1392
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL-QTLVSE-QPNKDVVEQMEK 735
L++++Q E+ + E Q ++++ E+Q+L Q+ +E Q E E+
Sbjct: 1393 -------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1445
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT--------------ENSSLTKEVQD 781
+E+++ V LE Q E EL A+R E L ++VQD
Sbjct: 1446 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 782 -LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL-LEAELLKVANKEKTVQDLKQEIK 839
+ K+ +V AS V+ + EK ++++EEL L+AE + ++ V+ +Q
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 840 ALKEEIGNVQLE-KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 898
AL+ + + E ++++ S K +L+ L+ + + ++ E + + A + +
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 899 DLQEE--------NESLKAHVQ--EVAQH-NLKEASSASQFEELEIVLKEKENELKRLEA 947
+ + E NE+L+ +Q EVAQ +L +A + Q EE E +E K E
Sbjct: 1626 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE---REARRRGKAEEQ 1682
Query: 948 MLKER---ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI--- 1001
+++R E +L + QL + + + ++ +L+ + Q EE L +
Sbjct: 1683 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1742
Query: 1002 --------SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD- 1052
E E E++ + E++ L + +++ EK+ + +EA A + L +
Sbjct: 1743 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1802
Query: 1053 --KVNKTSKERQQQVEAVE-------LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1103
++ ++E ++Q + E EA+ VL + + + L + EK+A+
Sbjct: 1803 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1862
Query: 1104 --------ECMAGTSGSEEVKVLEHKLKEADEMHTLLQL------ECEKYKSVLAETEGI 1149
E A E + +HK AD L QL E E+ K ++ +T
Sbjct: 1863 NERLRRLAEDEAFQRRRLEEQAAQHK---ADIEERLAQLRKASDSELERQKGLVEDT--- 1916
Query: 1150 LQKLQRSVEQEENKWKVKVD-----------ESHKTIKQMQSSFTSSEQ-ELERLRSENK 1197
+ +R VE+E K + E + + + S EQ ELE R
Sbjct: 1917 -LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1975
Query: 1198 DIENLRREREHLE------MELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
E RR RE E E+A +R + EV LK + E ++ + + E+ RQ
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2035
Query: 1252 ---NEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE 1308
+E + Q E +Q E++ QQ+L+ QS + + G+
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE--------LQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 1309 NSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
+ E + E + + V + ++L Q+ +Q
Sbjct: 2088 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2124
Score = 70.9 bits (172), Expect = 8e-12
Identities = 156/772 (20%), Positives = 313/772 (40%), Gaps = 109/772 (14%)
Query: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE--ISNKMEEFKILNDQNKALKSE-VQK 716
E + +H +++ QS LE+ Q E + E K + Q +A ++ V +
Sbjct: 957 EYGSCSHHYQQLLQS----------LEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1006
Query: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR------- 769
L+ + ++P ++ +++ + +K + E L G+ +++ + E++ A+
Sbjct: 1007 LRLPLDKEPARECAQRIAE-----QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1061
Query: 770 TENSSLT------KEVQDLKAKQNDQVSFASLV-------EELKKVIHEKDGKIKSVEEL 816
T S L ++V+ L A +++ SLV EE+ + E+ + ++V
Sbjct: 1062 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1121
Query: 817 L-EAELLKVANKEKTVQDLKQE--IKALKEEIGNVQL--EKAQQLSITSKVQELQNLLKG 871
L E E K + K+ Q Q+ AL++E+ Q E+ QQ V E++ +
Sbjct: 1122 LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRER 1180
Query: 872 KEEQMNTMKAVLEE---KEKDLANTGK--------------WLQDLQEENESLKA----H 910
+ + +AVL + ++++L G+ WLQD + E ++A
Sbjct: 1181 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1240
Query: 911 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970
Q V + +E + + E ++E + K+ +K+ E L + L+ V
Sbjct: 1241 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1300
Query: 971 KLFKSQIEQLKQQNYQQASSFPPH-EELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
K K +++ + Q+ H EL + S+ K IS ++ + E QR +
Sbjct: 1301 K--KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1358
Query: 1030 NDLREKNWEAMEA---LASTEKMLQDKVNKTSKERQQQVEAVELEAKEV-LKKLFPKVSV 1085
+ + A+E LA + + + +KE QQ+++ + +E + K S+
Sbjct: 1359 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1418
Query: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145
L E +AK + + + E +E +++L+ E +
Sbjct: 1419 QEELQQLRQSSEAEIQAK--------ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1470
Query: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ-----------ELERLRS 1194
EG LQ L+ E+ E + + +E+ + +Q+Q Q E E R
Sbjct: 1471 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1530
Query: 1195 ENK---DIENLRREREHLEMELEKAEMERSTYVTEVREL--KDLLTELQKK---LDDSYS 1246
+ + +E LR + E E L +AE+ER+ V E + ELQ K + +
Sbjct: 1531 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1590
Query: 1247 EAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI-----VKAA 1301
+ R +E ++ AQL E + +Q E ++ +A++ LE Q K ++
Sbjct: 1591 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQ 1647
Query: 1302 GDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ--AVNQQLTKEKE 1351
+ + S E E ++E + + + Q + Q Q+L K+++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Score = 43.1 bits (100), Expect = 0.002
Identities = 162/866 (18%), Positives = 343/866 (39%), Gaps = 113/866 (13%)
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL-----AEELHKVIAEKDKQIKQTED 621
L +Q +L ++A ++ HS +AA T + EE+ ++++ + ++
Sbjct: 597 LDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKE 656
Query: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
S ++ L KE+++K++QN L E A +E Q ++ +
Sbjct: 657 SYSALMRELELKEKKIKELQNAG----------DRLLREDHPARPTVESFQAALQTQWSW 706
Query: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD---VVEQMEKCIQ 738
+ L ++ + F+ +D +A + ++QKLQ + + + D V ++E +Q
Sbjct: 707 MLQLCCCIEAHLKENAAYFQFFSDVREA-EGQLQKLQEALRRKYSCDRSATVTRLEDLLQ 765
Query: 739 EKDEKLKTVEELLE--TGLIQVATKEEEL------NAIRTENSSLT----KEVQDLKAKQ 786
+ ++ + + E +GL + A +L + +R L K+V ++ +
Sbjct: 766 DAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVTVHK 824
Query: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE--KTVQDLKQEIKALKEE 844
D+ + + G +V + L+ N+E + V L+ + +AL
Sbjct: 825 GDECQLVGPAQPSHWKVLSSSGSEAAVPSV--CFLVPPPNQEAQEAVTRLEAQHQALVTL 882
Query: 845 IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL----ANTGKWLQDL 900
+ ++ L+ S +++Q + T+K EE+ + L + +L+D
Sbjct: 883 WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--EEQRQALHSLELHYQAFLRDS 940
Query: 901 Q-------EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Q E+ + + H + S Q + E + +ELK + L+ E
Sbjct: 941 QDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE 1000
Query: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ-----ASSFPPHEELLKVISEREKEI 1008
+ + +L D + + + EQ K Q + + E + + E
Sbjct: 1001 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1060
Query: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1068
L +EL+ +E R + EK + T+ ++V + +E+ ++ +AV
Sbjct: 1061 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG--AEEVLRAHEEQLKEAQAV 1118
Query: 1069 -----ELEA-KEVLKKLFPKVSV--PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120
ELEA K LKKL + P+ + + L G ++ E + G +V+V
Sbjct: 1119 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-AQEVGERLQQRHGERDVEVERW 1177
Query: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ------RSVEQEENKWKVKVDESHKT 1174
+ + A + E++++VLA+T+ ++L+ R + + + ++ +
Sbjct: 1178 RERVAQLL--------ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1229
Query: 1175 IKQMQS-SFTSSEQELERLRSENKDIENLRREREHLE----------MELEKAEMERSTY 1223
+Q+Q+ S+ E+LR E +E + R E +E ++ E++ TY
Sbjct: 1230 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1289
Query: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQN--------EELNLLKAQ----LNETLTKLRT 1271
+L+ + + +K S SE+V Q EL L +Q ++ETL ++
Sbjct: 1290 KA---QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1346
Query: 1272 EQ--------NERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
E+ ER+++A ++ +L ++ A + + E +E
Sbjct: 1347 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1406
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKE 1349
+V Q +Q+ LQ + Q E
Sbjct: 1407 AAVDAQQQKRSIQEELQQLRQSSEAE 1432
Score = 30.8 bits (68), Expect = 9.2
Identities = 48/217 (22%), Positives = 87/217 (40%), Gaps = 41/217 (18%)
Query: 1110 SGSEEVKVLEHKLKEADEMHT-LLQLECEKYKSVLAETEGILQKLQRSV---------EQ 1159
S EE+++L + + EM + + + K + EG +Q Q V E+
Sbjct: 309 SSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEK 368
Query: 1160 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAE-- 1217
E K V + E K ++ E ERL + + L+ E E +L +A+
Sbjct: 369 EWGKLHVAILEREKQLRS----------EFERLECLQRIVTKLQMEAGLCEEQLNQADAL 418
Query: 1218 MERSTYVTEVRELKDLLTELQKKLDDSYSEAVR---------------QNEELNLLKAQL 1262
++ + ++ E+++ LD + S +R Q E++ +L
Sbjct: 419 LQSDVRLLAAGKVPQRAGEVERDLDKADS-MIRLLFNDVQTLKDGRHPQGEQMYRRVYRL 477
Query: 1263 NETLTKLRTEQNERQK---VAGDLHKAQQSLELIQSK 1296
+E L +RTE N R K A AQ +L+ +Q +
Sbjct: 478 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 514
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 152 bits (385), Expect = 2e-36
Identities = 260/1326 (19%), Positives = 571/1326 (43%), Gaps = 180/1326 (13%)
Query: 29 MKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSD 88
+++ + +EV+ +RE+ + + K+ +++ + ++ + ++ +
Sbjct: 1397 LQQRMQEEVV---RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE---RS 1450
Query: 89 ALAVEDD-QVAPVPLNVVETS--------SSVRERKKKEKKQKPVLEEQV--IKESDASK 137
L +E++ +V + L E ++R R ++ + QK +E+ ++ +
Sbjct: 1451 RLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1510
Query: 138 IPGKKVEPVPVTKQPTPPSEAAASKKKPGQ--KKSKNGSDDQDKKVETLMVPSKRQEALP 195
K+ V + + +EAA K++ Q ++ + +++ ++++ V RQ +
Sbjct: 1511 SQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVA 1570
Query: 196 LHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLL 255
L + + K +S +KT + H V RE +
Sbjct: 1571 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-------------VAQLREEAERR 1617
Query: 256 KPDQVEGIQKSGTKKLKTETDKENAEVKFKDFL-LSLKTMMFSEDEALCVVDLLKEKSGV 314
Q E + + + E + E ++K + L L L+ ++ ++L + K+K
Sbjct: 1618 AQQQAEAERA----REEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1673
Query: 315 IQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVIT 374
++A ++ E +L E++ L ++ A T + QE++ R
Sbjct: 1674 EREARRRGKAEEQAVRQRELAEQE--LEKQRQLAEGTAQQRLAAEQELI----RLRAETE 1727
Query: 375 RMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVS 434
+ + + LE+E Q + + Q+ Q+++ + +VR +ME +A + R
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1787
Query: 435 NTTNQLESK---------QSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAA-- 483
+ +LE++ ++A L L ++ A+ +L E+ Q+ E ++ AE+ A
Sbjct: 1788 KSKQRLEAEAGRFRELAEEAARLRALAEE-AKRQRQLAEEDAARQRAEAERVLAEKLAAI 1846
Query: 484 -------TQLKVQLQEAE------RRWEEVQSYIRKRTAEHEAAQQ-DLQSKFV----AK 525
T+ ++ L+E E RR E +++ R+R E A + D++ + A
Sbjct: 1847 GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 526 ENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQI 585
++E++ + DTL ++Q+E+ ++ L S +K + L++++ I E
Sbjct: 1907 DSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE------ 1960
Query: 586 QQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTED----SLASERDRLTSKEEELKDIQ 641
+ ++ A + A ++ AE++++ ++ E+ SLA+E + ++ L++++
Sbjct: 1961 ----DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 642 NMNFLLKAEVQKLQALANEQAAAAHEL--EKMQQSVYVKDDKIRLLEEQLQHEISNKMEE 699
+ ++ E ++L+ A +++A +L E Q+ + ++ +Q + E+ +++
Sbjct: 2017 RLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 700 FKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQ----EKDEKLKTVEELLETGL 755
+ + DQ L+ E + + E V + E E+ E+LK E
Sbjct: 2076 EQSVLDQ---LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132
Query: 756 IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
Q E+L + ++ + + +Q + +E+ KK + + VE+
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD--AEMEKHKKFAEQTLRQKAQVEQ 2190
Query: 816 LLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQ 875
L L++ + L +E++ LK E E A+Q S+V+E ++ + E+
Sbjct: 2191 ELTTLRLQLEETDHQKNLLDEELQRLKAEA----TEAARQ---RSQVEEELFSVRVQMEE 2243
Query: 876 MNTMKAVLEEKEK-----DLANTGKWLQDLQEENESLKAHVQEVAQHNL--KEASSASQF 928
++ +KA +E + + D NT ++LQ EE E +K +E A+ ++ +EA+ Q
Sbjct: 2244 LSKLKARIEAENRALILRDKDNTQRFLQ---EEAEKMKQVAEEAARLSVAAQEAARLRQL 2300
Query: 929 EELEIVLKEKENELKRLEAMLKERESD-LSSKTQLLQD----VQDENKLFKSQIEQLKQQ 983
E ++ + E E M +E+ L ++ +LLQ Q++ + + EQ+ QQ
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ 2360
Query: 984 NYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEH----QRKKNND---LREKN 1036
++ F + L+ +R+ E+S E + LK V Q + D R++
Sbjct: 2361 LAEETQGF---QRTLEAERQRQLEMSA---EAERLKLRVAEMSRAQARAEEDAQRFRKQA 2414
Query: 1037 WEAMEALASTEKMLQDKVN--KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEW 1094
E E L TE Q+KV +T + ++QQ + +E + +L
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL--------------- 2459
Query: 1095 LHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD--EMHTLLQLECEKYKSVLAETEGILQK 1152
++ KE + +E K+L+ K +E + LLQ +S L+E + +LQ+
Sbjct: 2460 -----EREKEKL-----QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509
Query: 1153 LQRSVEQEENK----WKVKVDESHKTIKQMQSSFTSSEQELERL--------RSENKDIE 1200
+R +EQE+ K ++ +V ++ + ++ Q EQE +RL R +++ E
Sbjct: 2510 -ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2568
Query: 1201 NLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKA 1260
+RR++E EL++ E +R + E L E + L++ + A+ +EE+ +
Sbjct: 2569 GVRRKQE----ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQV 2624
Query: 1261 QLNETL 1266
+TL
Sbjct: 2625 AATKTL 2630
Score = 138 bits (347), Expect = 4e-32
Identities = 269/1431 (18%), Positives = 598/1431 (41%), Gaps = 233/1431 (16%)
Query: 39 AKQKREQ-KLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQV 97
A++++EQ + +P + E+ + ++ ++ H E R F A++D ++
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQR-FAKQYINAIKDYEL 1288
Query: 98 APVPLNV-VETSSSVRERKKKEKKQKPVLEEQV---IKESDASKIPGKKVEPVPVTKQPT 153
V +E +S ++ K + + V++E V S+ + + + ++ + T +
Sbjct: 1289 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1348
Query: 154 PPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASS 213
E A +++ ++++++ E K+++ H + K ++ K+
Sbjct: 1349 EEEERLAEQQR---------AEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ 1399
Query: 214 KKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKT 273
+ Q+ E V +E + A KR + ++++ +++S +++
Sbjct: 1400 RMQE-EVVRREEAAVDAQQ--------------QKRSI-----QEELQQLRQSSEAEIQA 1439
Query: 274 ETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQ 333
+ + A + + +E + VV L E + + + ++GEL L +
Sbjct: 1440 KARQAEAAERSR----------LRIEEEIRVVRLQLEAT----ERQRGGAEGELQALRAR 1485
Query: 334 LQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVI-TRMKDRIGTLEKEHNVFQN 392
+E + A K A +R ++ Q+ K ++ V + +R+K ++ Q
Sbjct: 1486 AEEAE----AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ- 1540
Query: 393 KIHVSYQETQQMQMKFQQVREQM-EAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKL 451
++++++ ++ ++ +AE+ +Q L A + +L+SK+++ K
Sbjct: 1541 -------ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKT 1593
Query: 452 RQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWE-EVQSYIRKRTAE 510
Q R + E +L++E ++ + A + + + + RW+ + +R R
Sbjct: 1594 AQ-LERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 511 HEAAQQDLQSKFVAK---------------------------ENEVQSLHSKLTDTLVSK 543
E AQQ ++ A+ E E++ T +
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR 1712
Query: 544 QQLEQRLMQLM----ESEQKRVNKEES---LQMQVQDILEQNEALKAQIQQFHSQIAAQT 596
EQ L++L + EQ+R EE LQ + ++ + L+A++ + +++
Sbjct: 1713 LAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL 1772
Query: 597 SASVLAEELHKVIAEKDKQIKQTE----DSLASERDRLTSKEEELKDIQNMNFLLKAEVQ 652
++ AEE + +EK KQ + E LA E RL + EE K + + AE
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQL-----AEED 1827
Query: 653 KLQALANEQAAAAHELEKMQQSVYVKDD-KIRLLEEQLQHEISNKMEEFKI-----LNDQ 706
+ A + A +L + ++ +K + +I L E++ ++E ++ E + L +Q
Sbjct: 1828 AARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1887
Query: 707 NKALKSEVQKLQTLVSE------QPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVAT 760
K+++++ + + + K +VE + ++ +E++ ++ E A
Sbjct: 1888 AAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAE 1947
Query: 761 KEEELNAIRT--ENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE--- 815
E EL IR+ E++ +KE +L+A + Q+ A+ E ++ E+ K + EE
Sbjct: 1948 LELELGRIRSNAEDTLRSKEQAELEAARQRQL--AAEEERRRREAEERVQKSLAAEEEAA 2005
Query: 816 ------LLEAELLKV------ANKEKTVQDLKQEIKALKEEIGNVQL---EKAQQLSITS 860
L E E LK +E+ Q+ ++++ L +E +L EKA ++
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQ-LAQEAAQKRLQAEEKAHAFAVQQ 2064
Query: 861 KVQELQNLLKGKEEQMNTMKAVLE--------------EKEKDLANTGKWLQDLQ----- 901
K QELQ L+ ++ ++ ++ E + E++ A + + +++ +
Sbjct: 2065 KEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2124
Query: 902 -EENESLKAHVQEVAQHNLKEA--SSASQFEELEIVLKEKENELKRLEAMLKERESDLSS 958
EE +A Q A+ KEA +A + + + L++K+ +E K E L
Sbjct: 2125 AEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQ 2184
Query: 959 KTQL----------LQDVQDENKLFKSQIEQLKQQNYQQA-SSFPPHEELLKVISEREKE 1007
K Q+ L++ + L ++++LK + + A EEL V + E
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME-- 2242
Query: 1008 ISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEA 1067
EL LK +E + + LR+K+ +T++ LQ++ K K+ ++
Sbjct: 2243 ------ELSKLKARIEAENRA-LILRDKD--------NTQRFLQEEAEK-MKQVAEEAAR 2286
Query: 1068 VELEAKEVLK-KLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEAD 1126
+ + A+E + + + + + E + ++K + T E ++L+ + + A
Sbjct: 2287 LSVAAQEAARLRQLAEEDLAQQRALAEKM--LKEKMQAVQEATRLKAEAELLQQQKELAQ 2344
Query: 1127 EMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSE 1186
E LQ + E+ LAE Q QR++E E + ++++ + +K + + ++
Sbjct: 2345 EQARRLQEDKEQMAQQLAEE---TQGFQRTLEAERQR-QLEMSAEAERLKLRVAEMSRAQ 2400
Query: 1187 QELERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYS 1246
E +D + R++ E + +L + E+ VT V+ L E+Q++ D +
Sbjct: 2401 ARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTL-----EIQRQQSDHDA 2449
Query: 1247 EAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTV 1306
E +L E + +L E+ + Q+ A L + ++ +Q + + +T
Sbjct: 2450 E-------------RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE--QLLQETQA 2494
Query: 1307 IENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ---AVNQQLTKEKEHYQ 1354
++ S +S + ++E + Q +L+QL Q A QQL +E++ Q
Sbjct: 2495 LQQSFLSEKDSLLQRERF---IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2542
Score = 135 bits (341), Expect = 2e-31
Identities = 235/1151 (20%), Positives = 482/1151 (41%), Gaps = 151/1151 (13%)
Query: 54 KKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAV--EDDQVAPVPLNVVETSSSV 111
+++AE++ ++ E + E++ E K ++AL + + ++VA +
Sbjct: 1611 REEAERRAQQQAEAERAR-EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQ 1669
Query: 112 RERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSK 171
+E ++E +++ EEQ +++ + ++ +++E + T AA +
Sbjct: 1670 KEEAEREARRRGKAEEQAVRQRELAE---QELEKQRQLAEGTAQQRLAAEQ--------- 1717
Query: 172 NGSDDQDKKVETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHAT 231
E + + ++ ++ Q ++E +++A++ QK + + + + A
Sbjct: 1718 ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAE 1767
Query: 232 TYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKKLKTETDK------ENAEVKFK 285
+ L A + ++ + ++L+ E + E A ++
Sbjct: 1768 MEVLLASKARAE--------------EESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1813
Query: 286 DFLLSLKTMMFSEDEALCVVD---LLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLA 342
+ + ED A + +L EK I +A + ++ E+ + + + +++ L
Sbjct: 1814 AEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA--LKEKEAENERLR 1871
Query: 343 AVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQ 402
+ ED A + R ++ + + E + + D LE++ + ++ + Q +
Sbjct: 1872 RLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD--SELERQKGLVEDTLRQRRQVEE 1929
Query: 403 QMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNEL 462
++ + + E+ A A L+ E G +R SN + L SK+ AEL RQ R +
Sbjct: 1930 EI-LALKASFEKAAAGKAELELELGRIR---SNAEDTLRSKEQAELEAARQ---RQLAAE 1982
Query: 463 TEKTGKLQQEEVQKKNA--EQAATQLKVQLQEAERRWEEVQSY--IRKRTAEH------- 511
E+ + +E VQK A E+AA Q K L+E ER +V+ +R+R +
Sbjct: 1983 EERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQL 2042
Query: 512 --EAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQM 569
EAAQ+ LQ++ A VQ +L TL +Q + +L E+ ++ + E ++
Sbjct: 2043 AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Query: 570 QVQDILEQN----EALKAQIQQFHSQIAAQTSASVLAEELHKVI---------------- 609
Q + Q+ E + Q Q A+ A AE+L K
Sbjct: 2103 QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2162
Query: 610 ------AEKDKQIKQTEDSL---ASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANE 660
AE +K K E +L A LT+ +L++ + LL E+Q+L+A A E
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222
Query: 661 QAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL 720
A ++E+ SV V+ +++ L+ +++ E N+ + ++ + L+ E +K++ +
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILRDKDNTQRFLQEEAEKMKQV 2280
Query: 721 VSEQPNKDV-VEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSL--TK 777
E V ++ + Q +E L L E L + +E ++ E L K
Sbjct: 2281 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2340
Query: 778 EVQDLKAK--QNDQVSFA-SLVEELKKVIHEKDG-KIKSVEELLEAELLKV--------- 824
E+ +A+ Q D+ A L EE + + + + +E EAE LK+
Sbjct: 2341 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQ 2400
Query: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
A E+ Q +++ + + E++ +L +++++ ++ + E++ A LE
Sbjct: 2401 ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2460
Query: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKR 944
+++ L K LQ EE +Q V Q L + + A Q + L EK++ L+R
Sbjct: 2461 REKEKLQQEAKLLQLKSEE-------MQTVQQEQLLQETQALQ----QSFLSEKDSLLQR 2509
Query: 945 LEAMLKERESDLSSKTQLLQD-VQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISE 1003
E +++ ++ L QL QD V +L + Q Q +Q ++ EE + E
Sbjct: 2510 -ERFIEQEKAKLE---QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2565
Query: 1004 REKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQ 1063
E+ + EL L+ + +R++ L E+N E L L ++ ++ + +
Sbjct: 2566 AEEGVRRKQEELQQLE---QQRRQQEELLAEENQRLREQL-----QLLEEQHRAALAHSE 2617
Query: 1064 QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM------AGTSGSEEVKV 1117
+V A ++ A + L + P+ + E H F+ ++ AG +EE++
Sbjct: 2618 EVTASQVAATKTLPNGRDALDGPA--AEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
Query: 1118 LEHKLKEADEM 1128
L DE+
Sbjct: 2676 LAQGHTTVDEL 2686
Score = 126 bits (317), Expect = 1e-28
Identities = 225/1168 (19%), Positives = 479/1168 (41%), Gaps = 113/1168 (9%)
Query: 238 DNADSSPVVDKREVIDLLKPDQ--VEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMM 295
+ + P+ D + V + L+ +Q +E I++ G K + + + KD+ L L T
Sbjct: 1235 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1294
Query: 296 FSEDEALCVVDLLKEKSG---VIQDALK-KSSKGELTTLIHQLQE--KDKLLAAVKEDAA 349
+ K +SG VIQ+ + ++ ELTTL Q + + L +E+
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1354
Query: 350 ATKDRCKQLTQ--EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMK 407
A + R ++ + E+ E+ + E+E Q ++ ++ +
Sbjct: 1355 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVD 1414
Query: 408 FQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTG 467
QQ + ++ E+ L+Q S Q +++Q+ + R R+ E+
Sbjct: 1415 AQQQKRSIQEELQQLRQS--------SEAEIQAKARQAEAAERSR---LRIEEEIRVVRL 1463
Query: 468 KLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKEN 527
+L+ E Q+ AE L+ + +EAE + + Q + + + Q + V +
Sbjct: 1464 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS 1523
Query: 528 EVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILE-QNEALKAQIQ 586
V++ + + Q LE+ +Q E+E++ E QVQ LE + +A++Q
Sbjct: 1524 RVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQ 1583
Query: 587 QFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFL 646
+ A +T A+ ++ +++ ++A R+ + ++ + +
Sbjct: 1584 SKRASFAEKT-------------AQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREE 1630
Query: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQ 706
+ E+++ Q ANE + E++ Q + + +E+ + E + + + Q
Sbjct: 1631 AERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQ 1690
Query: 707 NKALKSEVQKLQTLVSEQPNKDVVEQMEKC-IQEKDEKLKTVEELLETGLIQVATKEEEL 765
+ + E++K + L + + + E ++ + E+ + +LLE ++A + E
Sbjct: 1691 RELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE---ELARLQREA 1747
Query: 766 NAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVE-----ELLE-- 818
A + L E+ ++A+ ++ + EE + EK + E EL E
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 819 AELLKVANKEKTVQDLKQEIKA---------LKEEIGNV----QLEKAQQLSITSKVQEL 865
A L +A + K + L +E A L E++ + +L+ ++++ K E
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 866 QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSA 925
+ L + E++ + + E+ + A+ + L L++ ++S + + + L++
Sbjct: 1868 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1927
Query: 926 SQ--------FEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQI 977
+ FE+ E E EL R+ + E L SK Q + + +L +
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRS---NAEDTLRSKEQAELEAARQRQLAAEEE 1984
Query: 978 EQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREK-N 1036
+ ++ + S EE + R+++ + E++ LK VE R+ LRE+
Sbjct: 1985 RRRREAEERVQKSLAAEEE-----AARQRKAA--LEEVERLKAKVEEARR----LRERAE 2033
Query: 1037 WEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNL-SYGEWL 1095
E+ L ++ Q ++ K V+ E E ++ L++ + SV L E
Sbjct: 2034 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ---EQSVLDQLRGEAEAA 2090
Query: 1096 HGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQR 1155
++A+E A E +++EA+ L+ E+ A+ + +KL++
Sbjct: 2091 RRAAEEAEE--ARVQAEREAAQSRRQVEEAER----LKQSAEEQAQARAQAQAAAEKLRK 2144
Query: 1156 SVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEK 1215
EQE + + ++Q Q +++ E+E+ K E R++ +E EL
Sbjct: 2145 EAEQEAAR---RAQAEQAALRQKQ----AADAEMEK---HKKFAEQTLRQKAQVEQELTT 2194
Query: 1216 AEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ----NEELNLLKAQLNE-TLTKLR 1270
++ + E K+LL E ++L +EA RQ EEL ++ Q+ E + K R
Sbjct: 2195 LRLQ----LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKAR 2250
Query: 1271 TEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE-NSDVSPETESSEKETMSVSLN 1329
E R + D Q+ L+ K+ + A + + + + +E ++
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2310
Query: 1330 QTVTQLQQLLQAVNQQLTKEKEHYQVLE 1357
L++ +QAV Q+ T+ K ++L+
Sbjct: 2311 LAEKMLKEKMQAV-QEATRLKAEAELLQ 2337
Score = 121 bits (304), Expect = 4e-27
Identities = 224/1057 (21%), Positives = 432/1057 (40%), Gaps = 167/1057 (15%)
Query: 400 ETQQMQMKFQQVREQMEAEIAHLKQENGILRDA--VSNTTNQLESKQSAELNKLRQDYAR 457
E + + +++R Q EA+ LR A V Q ++ E+ + R+ A+
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 458 LVNELTEKTGKLQQEEVQKKNAEQAATQLKVQ----------LQEAERRWEEVQSY---- 503
L L L Q +V+++ EQ QL+ LQ+A RR E++Q+
Sbjct: 1188 L---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 504 ---IRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQ-QLEQRLMQL--MESE 557
+R++ + +A ++++ + K E Q + + + + QL QL + S
Sbjct: 1245 SQAVREQLRQEQALLEEIE-RHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1303
Query: 558 QKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
K+ + + +Q+ ++ ++ +S++ TS + + + + + +++ +
Sbjct: 1304 AKKPKVQSGSESVIQEYVD--------LRTHYSELTTLTSQYI--KFISETLRRMEEEER 1353
Query: 618 QTEDSLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYV 677
E A ER+RL E L E Q+ A A+ QA A E E +
Sbjct: 1354 LAEQQRAEERERLAEVEAAL------------EKQRQLAEAHAQAKAQAEREAKE----- 1396
Query: 678 KDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKL-QTLVSE-QPNKDVVEQMEK 735
L++++Q E+ + E Q ++++ E+Q+L Q+ +E Q E E+
Sbjct: 1397 -------LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAER 1449
Query: 736 CIQEKDEKLKTVEELLETGLIQVATKEEELNAIRT--------------ENSSLTKEVQD 781
+E+++ V LE Q E EL A+R E L ++VQD
Sbjct: 1450 SRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509
Query: 782 -LKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEEL-LEAELLKVANKEKTVQDLKQEIK 839
+ K+ +V AS V+ + EK ++++EEL L+AE + ++ V+ +Q
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 840 ALKEEIGNVQLE-KAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 898
AL+ + + E ++++ S K +L+ L+ + + ++ E + + A + +
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 899 DLQEE--------NESLKAHVQ--EVAQH-NLKEASSASQFEELEIVLKEKENELKRLEA 947
+ + E NE+L+ +Q EVAQ +L +A + Q EE E +E K E
Sbjct: 1630 EAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE---REARRRGKAEEQ 1686
Query: 948 MLKER---ESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI--- 1001
+++R E +L + QL + + + ++ +L+ + Q EE L +
Sbjct: 1687 AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQRE 1746
Query: 1002 --------SEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQD- 1052
E E E++ + E++ L + +++ EK+ + +EA A + L +
Sbjct: 1747 AAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1806
Query: 1053 --KVNKTSKERQQQVEAVE-------LEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAK 1103
++ ++E ++Q + E EA+ VL + + + L + EK+A+
Sbjct: 1807 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1866
Query: 1104 --------ECMAGTSGSEEVKVLEHKLKEADEMHTLLQL------ECEKYKSVLAETEGI 1149
E A E + +HK AD L QL E E+ K ++ +T
Sbjct: 1867 NERLRRLAEDEAFQRRRLEEQAAQHK---ADIEERLAQLRKASDSELERQKGLVEDT--- 1920
Query: 1150 LQKLQRSVEQEENKWKVKVD-----------ESHKTIKQMQSSFTSSEQ-ELERLRSENK 1197
+ +R VE+E K + E + + + S EQ ELE R
Sbjct: 1921 -LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1979
Query: 1198 DIENLRREREHLE------MELEKAEMERSTYVTEVRELKDLLTELQKKLDDSYSEAVRQ 1251
E RR RE E E+A +R + EV LK + E ++ + + E+ RQ
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQ 2039
Query: 1252 ---NEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIE 1308
+E + Q E +Q E++ QQ+L+ QS + + G+
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQE--------LQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 1309 NSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
+ E + E + + V + ++L Q+ +Q
Sbjct: 2092 RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ 2128
Score = 70.9 bits (172), Expect = 8e-12
Identities = 156/772 (20%), Positives = 313/772 (40%), Gaps = 109/772 (14%)
Query: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHE--ISNKMEEFKILNDQNKALKSE-VQK 716
E + +H +++ QS LE+ Q E + E K + Q +A ++ V +
Sbjct: 961 EYGSCSHHYQQLLQS----------LEQGAQEESRCQRCISELKDIRLQLEACETRTVHR 1010
Query: 717 LQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR------- 769
L+ + ++P ++ +++ + +K + E L G+ +++ + E++ A+
Sbjct: 1011 LRLPLDKEPARECAQRIAE-----QQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1065
Query: 770 TENSSLT------KEVQDLKAKQNDQVSFASLV-------EELKKVIHEKDGKIKSVEEL 816
T S L ++V+ L A +++ SLV EE+ + E+ + ++V
Sbjct: 1066 TLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT 1125
Query: 817 L-EAELLKVANKEKTVQDLKQE--IKALKEEIGNVQL--EKAQQLSITSKVQELQNLLKG 871
L E E K + K+ Q Q+ AL++E+ Q E+ QQ V E++ +
Sbjct: 1126 LPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV-EVERWRER 1184
Query: 872 KEEQMNTMKAVLEE---KEKDLANTGK--------------WLQDLQEENESLKA----H 910
+ + +AVL + ++++L G+ WLQD + E ++A
Sbjct: 1185 VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD 1244
Query: 911 VQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDEN 970
Q V + +E + + E ++E + K+ +K+ E L + L+ V
Sbjct: 1245 SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPA 1304
Query: 971 KLFKSQIEQLKQQNYQQASSFPPH-EELLKVISEREKEISGLWNELDSLKDAVEHQRKKN 1029
K K +++ + Q+ H EL + S+ K IS ++ + E QR +
Sbjct: 1305 K--KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1362
Query: 1030 NDLREKNWEAMEA---LASTEKMLQDKVNKTSKERQQQVEAVELEAKEV-LKKLFPKVSV 1085
+ + A+E LA + + + +KE QQ+++ + +E + K S+
Sbjct: 1363 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1422
Query: 1086 PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKSVLAE 1145
L E +AK + + + E +E +++L+ E +
Sbjct: 1423 QEELQQLRQSSEAEIQAK--------ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGG 1474
Query: 1146 TEGILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQ-----------ELERLRS 1194
EG LQ L+ E+ E + + +E+ + +Q+Q Q E E R
Sbjct: 1475 AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAARE 1534
Query: 1195 ENK---DIENLRREREHLEMELEKAEMERSTYVTEVREL--KDLLTELQKK---LDDSYS 1246
+ + +E LR + E E L +AE+ER+ V E + ELQ K + +
Sbjct: 1535 KQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTA 1594
Query: 1247 EAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSKI-----VKAA 1301
+ R +E ++ AQL E + +Q E ++ +A++ LE Q K ++
Sbjct: 1595 QLERSLQEEHVAVAQLREEAERRAQQQAEAERAR---EEAERELERWQLKANEALRLRLQ 1651
Query: 1302 GDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQ--AVNQQLTKEKE 1351
+ + S E E ++E + + + Q + Q Q+L K+++
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Score = 43.1 bits (100), Expect = 0.002
Identities = 162/866 (18%), Positives = 343/866 (39%), Gaps = 113/866 (13%)
Query: 567 LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVL-----AEELHKVIAEKDKQIKQTED 621
L +Q +L ++A ++ HS +AA T + EE+ ++++ + ++
Sbjct: 601 LDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKE 660
Query: 622 SLASERDRLTSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDK 681
S ++ L KE+++K++QN L E A +E Q ++ +
Sbjct: 661 SYSALMRELELKEKKIKELQNAG----------DRLLREDHPARPTVESFQAALQTQWSW 710
Query: 682 IRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD---VVEQMEKCIQ 738
+ L ++ + F+ +D +A + ++QKLQ + + + D V ++E +Q
Sbjct: 711 MLQLCCCIEAHLKENAAYFQFFSDVREA-EGQLQKLQEALRRKYSCDRSATVTRLEDLLQ 769
Query: 739 EKDEKLKTVEELLE--TGLIQVATKEEEL------NAIRTENSSLT----KEVQDLKAKQ 786
+ ++ + + E +GL + A +L + +R L K+V ++ +
Sbjct: 770 DAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVTVHK 828
Query: 787 NDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKE--KTVQDLKQEIKALKEE 844
D+ + + G +V + L+ N+E + V L+ + +AL
Sbjct: 829 GDECQLVGPAQPSHWKVLSSSGSEAAVPSV--CFLVPPPNQEAQEAVTRLEAQHQALVTL 886
Query: 845 IGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDL----ANTGKWLQDL 900
+ ++ L+ S +++Q + T+K EE+ + L + +L+D
Sbjct: 887 WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--EEQRQALHSLELHYQAFLRDS 944
Query: 901 Q-------EENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Q E+ + + H + S Q + E + +ELK + L+ E
Sbjct: 945 QDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACE 1004
Query: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQ-----ASSFPPHEELLKVISEREKEI 1008
+ + +L D + + + EQ K Q + + E + + E
Sbjct: 1005 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1064
Query: 1009 SGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAV 1068
L +EL+ +E R + EK + T+ ++V + +E+ ++ +AV
Sbjct: 1065 PTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQG--AEEVLRAHEEQLKEAQAV 1122
Query: 1069 -----ELEA-KEVLKKLFPKVSV--PSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVLEH 1120
ELEA K LKKL + P+ + + L G ++ E + G +V+V
Sbjct: 1123 PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG-AQEVGERLQQRHGERDVEVERW 1181
Query: 1121 KLKEADEMHTLLQLECEKYKSVLAETEGILQKLQ------RSVEQEENKWKVKVDESHKT 1174
+ + A + E++++VLA+T+ ++L+ R + + + ++ +
Sbjct: 1182 RERVAQLL--------ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRR 1233
Query: 1175 IKQMQS-SFTSSEQELERLRSENKDIENLRREREHLE----------MELEKAEMERSTY 1223
+Q+Q+ S+ E+LR E +E + R E +E ++ E++ TY
Sbjct: 1234 QEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTY 1293
Query: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQN--------EELNLLKAQ----LNETLTKLRT 1271
+L+ + + +K S SE+V Q EL L +Q ++ETL ++
Sbjct: 1294 KA---QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1350
Query: 1272 EQ--------NERQKVAGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKET 1323
E+ ER+++A ++ +L ++ A + + E +E
Sbjct: 1351 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1410
Query: 1324 MSVSLNQTVTQLQQLLQAVNQQLTKE 1349
+V Q +Q+ LQ + Q E
Sbjct: 1411 AAVDAQQQKRSIQEELQQLRQSSEAE 1436
Score = 30.8 bits (68), Expect = 9.2
Identities = 48/217 (22%), Positives = 87/217 (40%), Gaps = 41/217 (18%)
Query: 1110 SGSEEVKVLEHKLKEADEMHT-LLQLECEKYKSVLAETEGILQKLQRSV---------EQ 1159
S EE+++L + + EM + + + K + EG +Q Q V E+
Sbjct: 313 SSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEK 372
Query: 1160 EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAE-- 1217
E K V + E K ++ E ERL + + L+ E E +L +A+
Sbjct: 373 EWGKLHVAILEREKQLRS----------EFERLECLQRIVTKLQMEAGLCEEQLNQADAL 422
Query: 1218 MERSTYVTEVRELKDLLTELQKKLDDSYSEAVR---------------QNEELNLLKAQL 1262
++ + ++ E+++ LD + S +R Q E++ +L
Sbjct: 423 LQSDVRLLAAGKVPQRAGEVERDLDKADS-MIRLLFNDVQTLKDGRHPQGEQMYRRVYRL 481
Query: 1263 NETLTKLRTEQNERQK---VAGDLHKAQQSLELIQSK 1296
+E L +RTE N R K A AQ +L+ +Q +
Sbjct: 482 HERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 518
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.305 0.122 0.309
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,217,505
Number of Sequences: 37866
Number of extensions: 2083817
Number of successful extensions: 37663
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 592
Number of HSP's successfully gapped in prelim test: 1745
Number of HSP's that attempted gapping in prelim test: 11290
Number of HSP's gapped (non-prelim): 11778
length of query: 1357
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1242
effective length of database: 13,892,928
effective search space: 17255016576
effective search space used: 17255016576
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.