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Search of human proteins with 32967514
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
(507 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 990 0.0
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 990 0.0
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 970 0.0
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 969 0.0
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 921 0.0
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 921 0.0
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 921 0.0
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 898 0.0
gi|4506467 radixin [Homo sapiens] 384 e-106
gi|161702986 ezrin [Homo sapiens] 376 e-104
gi|21614499 ezrin [Homo sapiens] 376 e-104
gi|4505257 moesin [Homo sapiens] 376 e-104
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 114 2e-25
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 114 2e-25
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 114 2e-25
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 112 8e-25
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 105 1e-22
gi|150010540 FERM domain containing 4B [Homo sapiens] 102 6e-22
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 100 5e-21
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 100 5e-21
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 97 3e-20
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 97 3e-20
gi|223941885 protein tyrosine phosphatase, non-receptor type 3 i... 94 2e-19
gi|223941882 protein tyrosine phosphatase, non-receptor type 3 i... 94 2e-19
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 94 3e-19
gi|116063562 FERM domain containing 4A [Homo sapiens] 92 1e-18
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 91 2e-18
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 91 2e-18
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 90 6e-18
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 89 7e-18
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 990 bits (2559), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
Query: 61 YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA
Sbjct: 61 YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
Query: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN
Sbjct: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
Query: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA
Sbjct: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
Query: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL
Sbjct: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
Query: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE
Sbjct: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
Query: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD
Sbjct: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
Query: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN
Sbjct: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
Query: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
ENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 990 bits (2559), Expect = 0.0
Identities = 507/507 (100%), Positives = 507/507 (100%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLAS 60
Query: 61 YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA
Sbjct: 61 YAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEA 120
Query: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN
Sbjct: 121 EMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRN 180
Query: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA
Sbjct: 181 ISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKA 240
Query: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL
Sbjct: 241 QAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADL 300
Query: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE
Sbjct: 301 LAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEE 360
Query: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD
Sbjct: 361 SERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGD 420
Query: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN
Sbjct: 421 SLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHN 480
Query: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
ENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 481 ENSDRGGSSKHNTIKKPQAQGRRPICI 507
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 970 bits (2507), Expect = 0.0
Identities = 507/548 (92%), Positives = 507/548 (92%), Gaps = 41/548 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEV--------------------- 39
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEV
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60
Query: 40 --------------------KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 79
KKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF
Sbjct: 61 ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120
Query: 80 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 139
LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
Sbjct: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180
Query: 140 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 199
AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV
Sbjct: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240
Query: 200 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 259
FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE
Sbjct: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300
Query: 260 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 319
KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA
Sbjct: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360
Query: 320 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 379
AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR
Sbjct: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420
Query: 380 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 439
EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE
Sbjct: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480
Query: 440 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 499
KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA
Sbjct: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540
Query: 500 QGRRPICI 507
QGRRPICI
Sbjct: 541 QGRRPICI 548
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 969 bits (2506), Expect = 0.0
Identities = 507/549 (92%), Positives = 507/549 (92%), Gaps = 42/549 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 120
Query: 79 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY
Sbjct: 121 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 180
Query: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID
Sbjct: 181 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 240
Query: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR
Sbjct: 241 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 300
Query: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK
Sbjct: 301 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 360
Query: 319 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 378
AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA
Sbjct: 361 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 420
Query: 379 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 438
REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI
Sbjct: 421 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 480
Query: 439 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 498
EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ
Sbjct: 481 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 540
Query: 499 AQGRRPICI 507
AQGRRPICI
Sbjct: 541 AQGRRPICI 549
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 921 bits (2380), Expect = 0.0
Identities = 474/499 (94%), Positives = 481/499 (96%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
++F L + P+ +V + F +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
Query: 489 SKHNTIKKPQAQGRRPICI 507
SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 921 bits (2380), Expect = 0.0
Identities = 474/499 (94%), Positives = 481/499 (96%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
++F L + P+ +V + F +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
Query: 489 SKHNTIKKPQAQGRRPICI 507
SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 921 bits (2380), Expect = 0.0
Identities = 474/499 (94%), Positives = 481/499 (96%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
++F L + P+ +V + F +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
Query: 489 SKHNTIKKPQAQGRRPICI 507
SKHNTIKKPQAQGRRPICI
Sbjct: 572 SKHNTIKKPQAQGRRPICI 590
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 898 bits (2320), Expect = 0.0
Identities = 464/495 (93%), Positives = 472/495 (95%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
++F L + P+ +V + F +VKKQILDEKIYCPPEASVLLASYAVQAKYG
Sbjct: 92 VTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYG 151
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA
Sbjct: 152 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 211
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF
Sbjct: 212 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 271
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR
Sbjct: 272 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 331
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT
Sbjct: 332 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 391
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 368
EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA
Sbjct: 392 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEA 451
Query: 369 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 428
DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD
Sbjct: 452 DQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKD 511
Query: 429 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 488
TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS
Sbjct: 512 TDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGS 571
Query: 489 SKHNTIKKPQAQGRR 503
SKHNTIKK Q +
Sbjct: 572 SKHNTIKKLTLQSAK 586
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 384 bits (985), Expect = e-106
Identities = 201/485 (41%), Positives = 312/485 (64%), Gaps = 10/485 (2%)
Query: 19 PKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 78
P+ + ++ + F +VK+ IL+++IYCPPE +VLLASYAVQAKYGDY+ +HK G
Sbjct: 86 PEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPG 145
Query: 79 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 138
+LA + LLP+RV+ +++T E WEERI W+ EHRG R+++ MEYLKIAQDLEMYGVNY
Sbjct: 146 YLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNY 205
Query: 139 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 198
F I+NKKGTEL LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F IKP+DKK
Sbjct: 206 FEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAP 265
Query: 199 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 258
F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK +KQ+ER +L
Sbjct: 266 DFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLEN 325
Query: 259 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 318
EK+ RE AE+ ++ +ER ++ E E +++++ + KA ++E K ++
Sbjct: 326 EKKKREIAEKEKERIEREKEELMERLKQIEEQTIKAQKELEEQTRKALELDQERKRAKEE 385
Query: 319 AAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEAEVLALKMA---EESERRAKEADQL 371
A E+E + + A A + ++ + EQ E K+A E +++ +EA +
Sbjct: 386 AERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEW 445
Query: 372 KQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDM 431
+ A+E + K++L + + P PP P+ P + + S + + +
Sbjct: 446 QHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEHDENNAEASAELSNEGV 505
Query: 432 KRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKH 491
++ E+E+V +K++ +++QL L +E+ + + ++T D+LH EN + G K+
Sbjct: 506 --MNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENV-KAGRDKY 562
Query: 492 NTIKK 496
T+++
Sbjct: 563 KTLRQ 567
Score = 29.6 bits (65), Expect = 6.8
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 376 bits (966), Expect = e-104
Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
+ F + P+ ++ + F +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 76 LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG +D A +EYLKIA
Sbjct: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQ+ERQ+L EK+ RE ER ++++ R ++ E ++E ++A
Sbjct: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
EEE K +A E + ++ + A+R +EE +R ++ E LA ++AE + + A
Sbjct: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431
Query: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
+EA + K+D E E + RAK+ + + TK + P P PP + P + +SL
Sbjct: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489
Query: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
+ + LS E E++++ EK++ +Q QL L +E+ + + + T
Sbjct: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549
Query: 475 LDILHNENSDRGGSSKHNTIKK 496
DI+HNEN R G K+ T+++
Sbjct: 550 NDIIHNENM-RQGRDKYKTLRQ 570
Score = 29.6 bits (65), Expect = 6.8
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 376 bits (966), Expect = e-104
Identities = 212/502 (42%), Positives = 318/502 (63%), Gaps = 21/502 (4%)
Query: 9 MSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYG 68
+ F + P+ ++ + F +VK+ IL ++IYCPPE +VLL SYAVQAK+G
Sbjct: 76 LQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFG 135
Query: 69 DYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIA 128
DY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG +D A +EYLKIA
Sbjct: 136 DYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIA 195
Query: 129 QDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEF 188
QDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FPW+EIRNIS++DK+F
Sbjct: 196 QDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKF 255
Query: 189 TIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKAR 248
IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++EVQQMKAQAREEK +
Sbjct: 256 VIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQ 315
Query: 249 KQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQIT 308
KQ+ERQ+L EK+ RE ER ++++ R ++ E ++E ++A
Sbjct: 316 KQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQL 375
Query: 309 EEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVLALKMAEESERRA-- 365
EEE K +A E + ++ + A+R +EE +R ++ E LA ++AE + + A
Sbjct: 376 EEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALL 431
Query: 366 KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPPDI--PSFNLIGDSL 422
+EA + K+D E E + RAK+ + + TK + P P PP + P + +SL
Sbjct: 432 EEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESL 489
Query: 423 SFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETA 474
+ + LS E E++++ EK++ +Q QL L +E+ + + + T
Sbjct: 490 QDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTH 549
Query: 475 LDILHNENSDRGGSSKHNTIKK 496
DI+HNEN R G K+ T+++
Sbjct: 550 NDIIHNENM-RQGRDKYKTLRQ 570
Score = 29.6 bits (65), Expect = 6.8
Identities = 14/33 (42%), Positives = 20/33 (60%), Gaps = 3/33 (9%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
PK VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 376 bits (966), Expect = e-104
Identities = 210/497 (42%), Positives = 316/497 (63%), Gaps = 16/497 (3%)
Query: 7 SRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQAK 66
S + F + P+ + ++ + F +VK+ IL++ IYCPPE +VLLASYAVQ+K
Sbjct: 74 SPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSK 133
Query: 67 YGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLK 126
YGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG R++A +EYLK
Sbjct: 134 YGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLK 193
Query: 127 IAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK 186
IAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FPW+EIRNIS++DK
Sbjct: 194 IAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDK 253
Query: 187 EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEK 246
+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++EVQQMKAQAREEK
Sbjct: 254 KFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEK 313
Query: 247 ARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMANEALMRSEETAD 299
+KQMER L EK+ RE AE+ ++++ER RL Q++E+ A + L A
Sbjct: 314 HQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKAQQELEEQTRRAL 373
Query: 300 LLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAE 359
L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ LE L ++++
Sbjct: 374 ELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLALEMAELTARISQ 430
Query: 360 ESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIG 419
R K+ + + Q+A+ + ++ E+ T + P + PA D N G
Sbjct: 431 LEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAENEQDEQDEN--G 487
Query: 420 DSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILH 479
S D + M + E+E+ EK++ +Q+ L L +E+ + + ++TA D++H
Sbjct: 488 AEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTANDMIH 545
Query: 480 NENSDRGGSSKHNTIKK 496
EN R G K+ T+++
Sbjct: 546 AENM-RLGRDKYKTLRQ 561
Score = 33.5 bits (75), Expect = 0.47
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 232 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 285
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
Query: 286 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 339
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
Query: 340 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 377
+ ++ AE + L + R KQ + E
Sbjct: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
Score = 32.3 bits (72), Expect = 1.0
Identities = 15/33 (45%), Positives = 22/33 (66%), Gaps = 3/33 (9%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---VKKQILDEKI 48
PKT +VR+ TMDAE+EF + KQ+ D+ +
Sbjct: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVV 34
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 114 bits (285), Expect = 2e-25
Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)
Query: 34 EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
++ +++K IL+E+++C E S+LLAS A+QA+YGDY P VH + E LP RV+
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737
Query: 94 YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
++ +E + + + G + E E+E+LK+ Q L YGV++ + K T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795
Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
GV + G+ +++ N + T + FPW E + IS+S K+ T++ I F + ++
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854
Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
+ +L LC H ++ R S + Q +A Q E R + R A
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914
Query: 268 RTRDELERRLLQMKEE 283
T ++L R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 114 bits (285), Expect = 2e-25
Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)
Query: 34 EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
++ +++K IL+E+++C E S+LLAS A+QA+YGDY P VH + E LP RV+
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737
Query: 94 YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
++ +E + + + G + E E+E+LK+ Q L YGV++ + K T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795
Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
GV + G+ +++ N + T + FPW E + IS+S K+ T++ I F + ++
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854
Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
+ +L LC H ++ R S + Q +A Q E R + R A
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914
Query: 268 RTRDELERRLLQMKEE 283
T ++L R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 114 bits (285), Expect = 2e-25
Identities = 76/256 (29%), Positives = 130/256 (50%), Gaps = 9/256 (3%)
Query: 34 EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
++ +++K IL+E+++C E S+LLAS A+QA+YGDY P VH + E LP RV+
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737
Query: 94 YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
++ +E + + + G + E E+E+LK+ Q L YGV++ + K T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795
Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
GV + G+ +++ N + T + FPW E + IS+S K+ T++ I F + ++
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854
Query: 211 KLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAE 267
+ +L LC H ++ R S + Q +A Q E R + R A
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLAS 914
Query: 268 RTRDELERRLLQMKEE 283
T ++L R L ++ E
Sbjct: 915 STLNKLAVRPLSVQAE 930
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 112 bits (280), Expect = 8e-25
Identities = 66/203 (32%), Positives = 114/203 (56%), Gaps = 8/203 (3%)
Query: 34 EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
++ +++K IL+E+++C E S+LLAS A+QA+YGDY P VH + E LP RV+
Sbjct: 678 QYYLQLRKDILEERMHCDDETSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEK 737
Query: 94 YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLL 151
++ +E + + + G + E E+E+LK+ Q L YGV++ + K T +LL
Sbjct: 738 LDLS--YIKEELPKLHNTYVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILL 795
Query: 152 GVDALGLHIYDPENRL-TPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVN 210
GV + G+ +++ N + T + FPW E + IS+S K+ T++ I F + ++
Sbjct: 796 GVCSKGVLVFEVHNGVRTLVLRFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKIC 854
Query: 211 KLILQLCIGNH--DLFMRRRKAD 231
+ +L LC H L MR R+++
Sbjct: 855 QYLLHLCSYQHKFQLQMRARQSN 877
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 105 bits (261), Expect = 1e-22
Identities = 62/195 (31%), Positives = 106/195 (54%), Gaps = 15/195 (7%)
Query: 34 EFNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINL 93
++ ++K+ IL ++ CP + LLAS+AVQ++ GDYD S + G+L+ +P +
Sbjct: 125 QYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQ---- 180
Query: 94 YQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGV 153
P+ +E+ I + +H G + EAE YL A+ LE+YGV + R++ E+++GV
Sbjct: 181 ----PQDFEKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGV 236
Query: 154 DALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI---KPL-DKKIDVFKFNSSKLRV 209
+ G+ IY R+ +FPW +I IS+ K+F I K L + + + FN R
Sbjct: 237 MSGGILIYKNRVRMN---TFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRA 293
Query: 210 NKLILQLCIGNHDLF 224
K + + C+ +H F
Sbjct: 294 CKNLWKACVEHHTFF 308
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 102 bits (255), Expect = 6e-22
Identities = 99/427 (23%), Positives = 197/427 (46%), Gaps = 55/427 (12%)
Query: 6 ASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVKKQILDEKIYCPPEASVLLASYAVQA 65
A R S+ + KT TV + ++A+ C K QI E E LA++ +Q
Sbjct: 137 AVRFYIESISFLKDKT-TVELFFLNAKA---CVHKGQIEVES-----ETIFKLAAFILQE 187
Query: 66 KYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAWYAEHRGRARDEAEME 123
GDY + R L P + + Q P + E+R+ Y + +G R +A ++
Sbjct: 188 AKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEHYLKIKGLTRGQAVVQ 244
Query: 124 YLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISY 183
Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++ P+ F W ++ N+ +
Sbjct: 245 YMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVKPRKLFQWKQLENLYF 304
Query: 184 SDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQLCIGNHDLFMRRRKA- 230
+K+F ++ D ++I V + F S L V K I + I H ++ R+++
Sbjct: 305 REKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVMAISQHQFYLDRKQSK 364
Query: 231 ----DSLEVQQMKAQAREEKARKQMERQRLAREKQM------------REEAERTRDELE 274
+ + ++ E ++ + L + Q +++E + ++
Sbjct: 365 AKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLISSGSQDSEVSEEQKR 424
Query: 275 RRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATA 333
++L++K++ + E L++ EE + +A++T + K E +++R TA
Sbjct: 425 EKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLNIGEKPPQVRRRVGTA 484
Query: 334 IR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQLKQDLQEAREAERRA 385
+ +EE+ L E LE+ ++ K+ E +++ A E D K ++ ++ A
Sbjct: 485 FKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDLCKTVKKKRKQDYTDA 541
Query: 386 KQKLLEI 392
+KL EI
Sbjct: 542 MKKLQEI 548
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 99.8 bits (247), Expect = 5e-21
Identities = 79/358 (22%), Positives = 157/358 (43%), Gaps = 18/358 (5%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D + C ++++ I+ ++ C LL SY +Q++ GDYDP +H +++ +L
Sbjct: 261 LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 320
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EE++ + +R +A++E+L+ A+ L MYGV+ ++ +
Sbjct: 321 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 372
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G +++LGV + GL +Y + R+ FPW ++ ISY F IK + + ++
Sbjct: 373 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 429
Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
F R K + ++C+ H F R D++ + A + + + + Q
Sbjct: 430 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 488
Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
+ A +R + + A + A T+ + Q+ E A+K
Sbjct: 489 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 548
Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 378
+ + + +KA + +E E + EA K EE ++ +LK++ E+
Sbjct: 549 VPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMES 606
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 99.8 bits (247), Expect = 5e-21
Identities = 82/391 (20%), Positives = 171/391 (43%), Gaps = 22/391 (5%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D + C ++++ I+ ++ C LL SY +Q++ GDYDP +H +++ +L
Sbjct: 87 LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 146
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EE++ + +R +A++E+L+ A+ L MYGV+ ++ +
Sbjct: 147 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 198
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G +++LGV + GL +Y + R+ FPW ++ ISY F IK + + ++
Sbjct: 199 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 255
Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
F R K + ++C+ H F R D++ + A + + + + Q
Sbjct: 256 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 314
Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
+ A +R + + A + A T+ + Q+ E A+K
Sbjct: 315 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 374
Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEARE 380
+ + + +KA + +E E + EA + + + ++ + +DL +++E
Sbjct: 375 VPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQE 434
Query: 381 AERRAKQKLLEIATKPTYPPMNPIPAPLPPD 411
++ + E+ K + M +P P P +
Sbjct: 435 EIKKHHASISEL--KKNF--MESVPEPRPSE 461
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 97.1 bits (240), Expect = 3e-20
Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 15/195 (7%)
Query: 38 EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
++K I + ++ CP ++V+LASYAVQ+ +GDY+ S+H G+L+ +P +
Sbjct: 129 QLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------- 180
Query: 98 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
E + ++ + + +H G + EAE Y+ IA+ L+ YGV + R+ +L++G+ + G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLI 213
+ +Y + +PW I IS+ K+F I K + + + FN R K +
Sbjct: 241 VAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNL 297
Query: 214 LQLCIGNHDLFMRRR 228
+ C+ +H F ++
Sbjct: 298 WKSCVEHHTFFQAKK 312
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 97.1 bits (240), Expect = 3e-20
Identities = 54/195 (27%), Positives = 102/195 (52%), Gaps = 15/195 (7%)
Query: 38 EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
++K I + ++ CP ++V+LASYAVQ+ +GDY+ S+H G+L+ +P +
Sbjct: 129 QLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-------- 180
Query: 98 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
E + ++ + + +H G + EAE Y+ IA+ L+ YGV + R+ +L++G+ + G
Sbjct: 181 NEDFLTKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAG 240
Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLI 213
+ +Y + +PW I IS+ K+F I K + + + FN R K +
Sbjct: 241 VAVY---RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNL 297
Query: 214 LQLCIGNHDLFMRRR 228
+ C+ +H F ++
Sbjct: 298 WKSCVEHHTFFQAKK 312
>gi|223941885 protein tyrosine phosphatase, non-receptor type 3
isoform 4 [Homo sapiens]
Length = 737
Score = 94.4 bits (233), Expect = 2e-19
Identities = 53/190 (27%), Positives = 99/190 (52%), Gaps = 15/190 (7%)
Query: 43 ILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWE 102
I + ++ CP ++V+LASYAVQ+ +GDY+ S+H G+L+ +P + E +
Sbjct: 3 ICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ--------NEDFL 54
Query: 103 ERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYD 162
++ + + +H G + EAE Y+ IA+ L+ YGV + R+ +L++G+ + G+ +Y
Sbjct: 55 TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY- 113
Query: 163 PENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLILQLCI 218
+ +PW I IS+ K+F I K + + + FN R K + + C+
Sbjct: 114 --RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCV 171
Query: 219 GNHDLFMRRR 228
+H F ++
Sbjct: 172 EHHTFFQAKK 181
>gi|223941882 protein tyrosine phosphatase, non-receptor type 3
isoform 3 [Homo sapiens]
Length = 782
Score = 94.4 bits (233), Expect = 2e-19
Identities = 53/190 (27%), Positives = 99/190 (52%), Gaps = 15/190 (7%)
Query: 43 ILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWE 102
I + ++ CP ++V+LASYAVQ+ +GDY+ S+H G+L+ +P + E +
Sbjct: 3 ICEGRLTCPLNSAVVLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ--------NEDFL 54
Query: 103 ERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYD 162
++ + + +H G + EAE Y+ IA+ L+ YGV + R+ +L++G+ + G+ +Y
Sbjct: 55 TKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY- 113
Query: 163 PENRLTPKISFPWNEIRNISYSDKEFTI----KPLDKKIDVFKFNSSKLRVNKLILQLCI 218
+ +PW I IS+ K+F I K + + + FN R K + + C+
Sbjct: 114 --RKYICTSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCV 171
Query: 219 GNHDLFMRRR 228
+H F ++
Sbjct: 172 EHHTFFQAKK 181
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 94.0 bits (232), Expect = 3e-19
Identities = 73/330 (22%), Positives = 145/330 (43%), Gaps = 18/330 (5%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D + C ++++ I+ ++ C LL SY +Q++ GDYDP +H +++ +L
Sbjct: 87 LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKL 146
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EE++ + +R +A++E+L+ A+ L MYGV+ ++ +
Sbjct: 147 APNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLE 198
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G +++LGV + GL +Y + R+ FPW ++ ISY F IK + + ++
Sbjct: 199 GVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIG 255
Query: 202 FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQ 261
F R K + ++C+ H F R D++ + A + + + + Q
Sbjct: 256 FKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASAL 314
Query: 262 MREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEA-KLLAQKAA 320
+ A +R + + A + A T+ + Q+ E A+K
Sbjct: 315 IDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTV 374
Query: 321 EAEQEMQRIKATAIRTEEEKRLMEQKVLEA 350
+ + + +KA + +E E + EA
Sbjct: 375 VPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 91.7 bits (226), Expect = 1e-18
Identities = 87/394 (22%), Positives = 168/394 (42%), Gaps = 37/394 (9%)
Query: 35 FNCEVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLY 94
F K I E I E LASY +Q GD+ + R L + LP + + +
Sbjct: 118 FFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEH 177
Query: 95 QMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVD 154
E+R+ Y + G+ R +A + Y+ I + L YGV+Y+A+++K+G LG+
Sbjct: 178 PSLAYC-EDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLS 236
Query: 155 ALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIK---PLDKKIDVFKFNSSKLRVN- 210
G+ YD +++ P+ F W ++ N+ + +K+F+++ P + F S + V+
Sbjct: 237 YKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHT 296
Query: 211 --------KLILQLCIGNHDLFMRRRKADS-----LEVQQMKAQAREEKARKQMERQRLA 257
K I + I H ++ R+++ S + ++ E K + +
Sbjct: 297 WYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMG 356
Query: 258 REKQM------------REEAERTRDELERRLLQMKEEATMANEAL-MRSEETADLLAEK 304
+ ++ +E++ ++ + L +K E L R EE L +
Sbjct: 357 SKGKIISGSSGSLLSSGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLRE 416
Query: 305 AQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMA------ 358
A++T + E ++R TA + +E+K L + + E E L + A
Sbjct: 417 AELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQIT 476
Query: 359 EESERRAKEADQLKQDLQEAREAERRAKQKLLEI 392
E + R A + + K+ ++ + + A +KL EI
Sbjct: 477 EAARRLASDPNVSKKLKKQRKTSYLNALKKLQEI 510
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 91.3 bits (225), Expect = 2e-18
Identities = 63/203 (31%), Positives = 99/203 (48%), Gaps = 16/203 (7%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D + C +++ I+ ++ C LL SYAVQA+ GDYD H ++++
Sbjct: 121 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 180
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EERI + +RG EAE+ +L+ A+ L MYGV+ ++ +
Sbjct: 181 APNQTREL--------EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSE 232
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G +++LGV A GL IY R+ F W +I ISY F IK + + F+
Sbjct: 233 GIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIG 289
Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
F R K + ++CI +H F
Sbjct: 290 FKLPNHRSAKRLWKVCIEHHTFF 312
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 91.3 bits (225), Expect = 2e-18
Identities = 63/203 (31%), Positives = 99/203 (48%), Gaps = 16/203 (7%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D + C +++ I+ ++ C LL SYAVQA+ GDYD H ++++
Sbjct: 183 LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQAELGDYDAEEHVGNYVSELRF 242
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EERI + +RG EAE+ +L+ A+ L MYGV+ ++ +
Sbjct: 243 APNQTREL--------EERIMELHKTYRGMTPGEAEIHFLENAKKLSMYGVDLHHAKDSE 294
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G +++LGV A GL IY R+ F W +I ISY F IK + + F+
Sbjct: 295 GIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYKRSNFYIKIRPGEYEQFESTIG 351
Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
F R K + ++CI +H F
Sbjct: 352 FKLPNHRSAKRLWKVCIEHHTFF 374
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 89.7 bits (221), Expect = 6e-18
Identities = 56/191 (29%), Positives = 92/191 (48%), Gaps = 15/191 (7%)
Query: 38 EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 97
+++ I+ ++ C LL SY VQ++ GDYDP ++++ P L
Sbjct: 208 QLRDDIVSGRLPCSFVTLALLGSYTVQSELGDYDPDECGSDYISEFRFAPNHTKEL---- 263
Query: 98 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 157
E+++ + HRG EAEM +L+ A+ L MYGV+ ++ +G E++LGV A G
Sbjct: 264 ----EDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDLHHAKDSEGVEIMLGVCASG 319
Query: 158 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK----FNSSKLRVNKLI 213
L IY R+ F W ++ ISY F IK + + F+ F R K +
Sbjct: 320 LLIYRDRLRIN---RFAWPKVLKISYKRNNFYIKIRPGEFEQFESTIGFKLPNHRAAKRL 376
Query: 214 LQLCIGNHDLF 224
++C+ +H F
Sbjct: 377 WKVCVEHHTFF 387
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 89.4 bits (220), Expect = 7e-18
Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 16/203 (7%)
Query: 27 VTMDAEMEFNC-EVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEEL 85
+T D F C ++++ I ++ C LL SY +QA+ GDYDP H L++ +
Sbjct: 304 LTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELGDYDPEEHGSIDLSEFQF 363
Query: 86 LPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKK 145
P + L EE++ + HRG + +A+ ++L+ A+ L MYGV+ ++ +
Sbjct: 364 APTQTKEL--------EEKVAELHKTHRGLSPAQADSQFLENAKRLSMYGVDLHHAKDSE 415
Query: 146 GTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFK---- 201
G ++ LGV A GL IY R+ F W +I ISY F IK +++ F+
Sbjct: 416 GVDIKLGVCANGLLIYKDRLRIN---RFAWPKILKISYKRSNFYIKVRPAELEQFESTIG 472
Query: 202 FNSSKLRVNKLILQLCIGNHDLF 224
F R K + ++C+ +H +
Sbjct: 473 FKLPNHRAAKRLWKVCVEHHTFY 495
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.129 0.352
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,475,290
Number of Sequences: 37866
Number of extensions: 806324
Number of successful extensions: 18292
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 611
Number of HSP's successfully gapped in prelim test: 1016
Number of HSP's that attempted gapping in prelim test: 6030
Number of HSP's gapped (non-prelim): 6628
length of query: 507
length of database: 18,247,518
effective HSP length: 107
effective length of query: 400
effective length of database: 14,195,856
effective search space: 5678342400
effective search space used: 5678342400
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.