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Search of human proteins with 124028529
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124028529 symplekin [Homo sapiens]
(1274 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124028529 symplekin [Homo sapiens] 2481 0.0
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 49 2e-05
gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Hom... 45 3e-04
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 45 4e-04
gi|41281612 zinc finger protein 828 [Homo sapiens] 45 6e-04
gi|33286446 opioid growth factor receptor [Homo sapiens] 44 8e-04
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 44 8e-04
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 44 0.001
gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo ... 43 0.002
gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo ... 43 0.002
gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo ... 43 0.002
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2... 42 0.003
gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens] 41 0.008
gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens] 41 0.008
gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens] 41 0.008
gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens] 41 0.008
gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens] 41 0.008
gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens] 41 0.008
gi|148806884 AKT1 substrate 1 (proline-rich) [Homo sapiens] 41 0.008
gi|148806906 AKT1 substrate 1 (proline-rich) [Homo sapiens] 41 0.008
gi|148806896 AKT1 substrate 1 (proline-rich) [Homo sapiens] 41 0.008
gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens] 40 0.011
gi|222537747 hypothetical protein LOC342979 [Homo sapiens] 40 0.014
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 40 0.014
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 40 0.019
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 40 0.019
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 40 0.019
gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo s... 40 0.019
gi|40556370 PHD finger protein 15 [Homo sapiens] 40 0.019
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 39 0.024
>gi|124028529 symplekin [Homo sapiens]
Length = 1274
Score = 2481 bits (6431), Expect = 0.0
Identities = 1274/1274 (100%), Positives = 1274/1274 (100%)
Query: 1 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE 60
MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE
Sbjct: 1 MASGSGDSVTRRSVASQFFTQEEGPGIDGMTTSERVVDLLNQAALITNDSKITVLKQVQE 60
Query: 61 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD 120
LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD
Sbjct: 61 LIINKDPTLLDNFLDEIIAFQADKSIEVRKFVIGFIEEACKRDIELLLKLIANLNMLLRD 120
Query: 121 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR 180
ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR
Sbjct: 121 ENVNVVKKAILTMTQLYKVALQWMVKSRVISELQEACWDMVSAMAGDIILLLDSDNDGIR 180
Query: 181 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL 240
THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL
Sbjct: 181 THAIKFVEGLIVTLSPRMADSEIPRRQEHDISLDRIPRDHPYIQYNVLWEEGKAALEQLL 240
Query: 241 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN 300
KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN
Sbjct: 241 KFMVHPAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKN 300
Query: 301 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM 360
LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM
Sbjct: 301 LKLHLLSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKM 360
Query: 361 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV 420
KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV
Sbjct: 361 KLEPNLGEDDEDKDLEPGPSGTSKASAQISGQSDTDITAEFLQPLLTPDNVANLVLISMV 420
Query: 421 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK 480
YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK
Sbjct: 421 YLPEAMPASFQAIYTPVESAGTEAQIKHLARLMATQMTAAGLGPGVEQTKQCKEEPKEEK 480
Query: 481 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR 540
VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR
Sbjct: 481 VVKTESVLIKRRLSAQGQAISVVGSLSSMSPLEEEAPQAKRRPEPIIPVTQPRLAGAGGR 540
Query: 541 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL 600
KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL
Sbjct: 541 KKIFRLSDVLKPLTDAQVEAMKLGAVKRILRAEKAVACSGAAQVRIKILASLVTQFNSGL 600
Query: 601 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK 660
KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK
Sbjct: 601 KAEVLSFILEDVRARLDLAFAWLYQEYNAYLAAGASGSLDKYEDCLIRLLSGLQEKPDQK 660
Query: 661 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL 720
DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL
Sbjct: 661 DGIFTKVVLEAPLITESALEVVRKYCEDESRTYLGMSTLRDLIFKRPSRQFQYLHVLLDL 720
Query: 721 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA 780
SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA
Sbjct: 721 SSHEKDKVRSQALLFIKRMYEKEQLREYVEKFALNYLQLLVHPNPPSVLFGADKDTEVAA 780
Query: 781 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE 840
PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE
Sbjct: 781 PWTEETVKQCLYLYLALLPQNHKLIHELAAVYTEAIADIKRTVLRVIEQPIRGMGMNSPE 840
Query: 841 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK 900
LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK
Sbjct: 841 LLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDVRFLIPVLNGLEK 900
Query: 901 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK 960
KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK
Sbjct: 901 KEVIQALPKLIKLNPIVVKEVFNRLLGTQHGEGNSALSPLNPGELLIALHNIDSVKCDMK 960
Query: 961 SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 1020
SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL
Sbjct: 961 SIIKATNLCFAERNVYTSEVLAVVMQQLMEQSPLPMLLMRTVIQSLTMYPRLGGFVMNIL 1020
Query: 1021 SRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVR 1080
SRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVR
Sbjct: 1021 SRLIMKQVWKYPKVWEGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVR 1080
Query: 1081 SFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIG 1140
SFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIG
Sbjct: 1081 SFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIG 1140
Query: 1141 LRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECET 1200
LRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECET
Sbjct: 1141 LRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECET 1200
Query: 1201 PGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP 1260
PGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP
Sbjct: 1201 PGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP 1260
Query: 1261 AAEDAREPEAKGNS 1274
AAEDAREPEAKGNS
Sbjct: 1261 AAEDAREPEAKGNS 1274
>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
Length = 2217
Score = 49.3 bits (116), Expect = 2e-05
Identities = 45/140 (32%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 1101 SGKQEPEAKEAPAGP--------LEEDDLEP--LTLAPAPAPRPPQDLIGL--------R 1142
+G EP AK A GP +E D EP L A AP P+PPQ L R
Sbjct: 24 AGMAEPRAKAARPGPQRFLRRSVVESDQEEPPGLEAAEAPGPQPPQPLQRRVLLLCKTRR 83
Query: 1143 LAQEKALKRQLEEEQKL---KPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFR---EEGP 1196
L E+A R +PG GAP+ + P P + PGP P A++ + GP
Sbjct: 84 LIAERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVETAPAPDGGP 143
Query: 1197 ECETPGIFISMDDDSGLTEA 1216
E +D G EA
Sbjct: 144 REEAAATV--RKEDEGAAEA 161
>gi|205361109 multiple C2 domains, transmembrane 1 isoform L [Homo
sapiens]
Length = 999
Score = 45.4 bits (106), Expect = 3e-04
Identities = 34/89 (38%), Positives = 43/89 (48%), Gaps = 7/89 (7%)
Query: 1161 PGGVG---APSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAA 1217
PGG APSSSS S S S+ P PPP + R+EG + PG + S L A
Sbjct: 148 PGGRSPDSAPSSSSASSSLSSSPQPPPRGDRA--RDEGARRQGPGAHLCHQKSSSLPGTA 205
Query: 1218 LLDSSLEGPLPKETAAGGLTLKEERSPQT 1246
L+ LE P P A + E R+P+T
Sbjct: 206 CLEQLLEPPPP--PAEPARSPAESRAPET 232
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 45.1 bits (105), Expect = 4e-04
Identities = 48/178 (26%), Positives = 75/178 (42%), Gaps = 18/178 (10%)
Query: 1104 QEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGG 1163
Q P A+E+P+ L + L P + +P+ PP ++ L EK+ +L E + P
Sbjct: 334 QPPSAEESPSVELLAEILPP-SAEESPSEEPPAEI--LPPPAEKSPSVELLGEIR-SPSA 389
Query: 1164 VGAPSSSSPSPSPSA------RPGPPPSEEAMD-----FREEGPECETPGIFISMDDDSG 1212
AP P P+ A + PP EE + EE P E + +S ++
Sbjct: 390 QKAPIEVQPLPAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETP 449
Query: 1213 LTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEA 1270
EA + + PLPKET A + + + T P E + SP +E+ EA
Sbjct: 450 AEEAP---TEFQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEA 504
Score = 40.8 bits (94), Expect = 0.008
Identities = 49/192 (25%), Positives = 75/192 (39%), Gaps = 28/192 (14%)
Query: 1083 TPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLR 1142
T ++A ++ EAS ++ P + P P EE P + P PA P ++
Sbjct: 584 TTAEEASAAIQLLAATEASAEEAPAEVQPP--PAEE---APAEVQPPPAEEAPAEV---- 634
Query: 1143 LAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSA--RPGPPPSEEAMDFREEGPECET 1200
Q + E Q P AP+ P P+ A PPP+EEA + P ET
Sbjct: 635 --QPPPAEEAPAEVQP--PPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEET 690
Query: 1201 PGIFISMDDDSGLTEAALLDS--SLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTP 1258
P +++ + D + E + K + L L EE P+GE + +
Sbjct: 691 P-----IEETLAAVHSPPADDVPAEEASVDKHSPPADLLLTEE------FPIGEASAEVS 739
Query: 1259 SPAAEDAREPEA 1270
P +E E EA
Sbjct: 740 PPPSEQTPEDEA 751
Score = 33.9 bits (76), Expect = 1.0
Identities = 54/220 (24%), Positives = 85/220 (38%), Gaps = 34/220 (15%)
Query: 1057 PPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPL 1116
P + L +K P + LL +RS P Q P + + +E AK P +
Sbjct: 364 PAEILPPPAEKSPSVE--LLGEIRS--PSAQK-APIEVQPLPAEGALEEAPAKVEPP-TV 417
Query: 1117 EEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSP 1176
EE + L P APR E+A + QL + P+ +P+
Sbjct: 418 EETLADVQPLLPEEAPR------------EEARELQLSTAME-------TPAEEAPTEFQ 458
Query: 1177 SARPGPPPSEEA-----MDFREEGPECETPGIFIS-MDDDSGLTEAALLDSSLEGPLPKE 1230
S P +EEA + E P ETP S + +++ EA + ++ PL +E
Sbjct: 459 SPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEA---HAEVQSPLAEE 515
Query: 1231 TAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEA 1270
T A + + + AP E + SP +E+ EA
Sbjct: 516 TTAEEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEA 555
>gi|41281612 zinc finger protein 828 [Homo sapiens]
Length = 812
Score = 44.7 bits (104), Expect = 6e-04
Identities = 45/168 (26%), Positives = 70/168 (41%), Gaps = 13/168 (7%)
Query: 1042 CQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPN-SIMTILEA 1100
C +P+S L + Q+LG+V PE +P + P + + + + T L +
Sbjct: 119 CNSAEPKSIPA-LSMETQKLGSVLS--PESPKP--TPLTPLEPQKPGSVVSPELQTPLPS 173
Query: 1101 SGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLK 1160
+P + +P P E LAP P+P P + + + L ++Q
Sbjct: 174 PEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHF 233
Query: 1161 PGGVGAPSSSSP-SPSPSARP---GPPPS---EEAMDFREEGPECETP 1201
P +G PS+SSP SP +A P GP P+ E R PE P
Sbjct: 234 PETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKP 281
Score = 35.4 bits (80), Expect = 0.35
Identities = 44/177 (24%), Positives = 63/177 (35%), Gaps = 27/177 (15%)
Query: 1107 EAKEAPAGPLEEDDLEPLTLAPA---PAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGG 1163
E + PL E P A PA +G L+ E L + KPG
Sbjct: 102 ETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGS 161
Query: 1164 VGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSL 1223
V +P +P PSP P P S + + + P CE+ + A +
Sbjct: 162 VVSPELQTPLPSP--EPSKPASVSSPEPPKSVPVCESQKL------------APVPSPEP 207
Query: 1224 EGPLP------KETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGNS 1274
+ P P K T + K+ P+TL P + ++P AA PE G S
Sbjct: 208 QKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAA----SPEPWGPS 260
>gi|33286446 opioid growth factor receptor [Homo sapiens]
Length = 677
Score = 44.3 bits (103), Expect = 8e-04
Identities = 44/174 (25%), Positives = 60/174 (34%), Gaps = 48/174 (27%)
Query: 1111 APAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSS 1170
+PAGP ++ E + P P P P+
Sbjct: 525 SPAGPAGDEPAESPSETPGPRP--------------------------------AGPAGD 552
Query: 1171 SPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKE 1230
P+ SPS PGP P+ A D E P ETPG +G T +S E P P+
Sbjct: 553 EPAESPSETPGPRPAGPAGDEPAESPS-ETPG-----PSPAGPTRDEPAESPSETPGPRP 606
Query: 1231 TAAGGLTLKEERS----PQTLAPVGEDAMKT------PSPAAEDAREPEAKGNS 1274
G E S P+ P G++ ++ PSPA EP G +
Sbjct: 607 AGPAGDEPAESPSETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPAKAGEA 660
Score = 38.5 bits (88), Expect = 0.041
Identities = 43/161 (26%), Positives = 61/161 (37%), Gaps = 29/161 (18%)
Query: 1127 APAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSS-----------SPSPS 1175
+PAP+ P E ++ E K G G+PS + P+ S
Sbjct: 484 SPAPSGHPKAG------HSENGVEEDTEGRTGPKEGTPGSPSETPGPSPAGPAGDEPAES 537
Query: 1176 PSARPGPPPSEEAMDFREEGPECETPGIFIS--MDDDSGLTEAALLDSSLEGPLPKETAA 1233
PS PGP P+ A D E P ETPG + D+ + + S GP E A
Sbjct: 538 PSETPGPRPAGPAGDEPAESPS-ETPGPRPAGPAGDEPAESPSETPGPSPAGPTRDEPAE 596
Query: 1234 GGLTLKEERSPQTLAPVGEDAMKTPS------PAAEDAREP 1268
+ E P+ P G++ ++PS PA EP
Sbjct: 597 ---SPSETPGPRPAGPAGDEPAESPSETPGPRPAGPAGDEP 634
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 44.3 bits (103), Expect = 8e-04
Identities = 60/227 (26%), Positives = 86/227 (37%), Gaps = 32/227 (14%)
Query: 1057 PPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAG-- 1114
P + A++ C +P HV S P + + + +A + EP+ EAP
Sbjct: 381 PTDEPDALYVACQG--QPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQL-EAPLNEE 437
Query: 1115 -----PLEEDDLEPL-----TLAPAPAPR---PPQDLIGLRLAQEKALKRQLEEEQKLKP 1161
P EE L P T P A R PP++L L + L R LEE P
Sbjct: 438 MPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPLEESPLSPP 497
Query: 1162 GGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDS 1221
P S SP P + P P E + EE P +S ++ +S
Sbjct: 498 -----PEESPLSPPPESSPFSPLEESPLSPPEESPPSPALETPLSPPPEASPLSPPFEES 552
Query: 1222 SLEGPLPKE------TAAGGLTLKEERSPQTLAPVGEDAMKTPSPAA 1262
L P P+E A L+ E SP ++P E++ +P P A
Sbjct: 553 PLSPP-PEELPTSPPPEASRLSPPPEESP--MSPPPEESPMSPPPEA 596
Score = 40.8 bits (94), Expect = 0.008
Identities = 45/161 (27%), Positives = 63/161 (39%), Gaps = 23/161 (14%)
Query: 1106 PEAKEAPAGPLEEDDLEPLTLAPAPAPR------PPQDLIGLRLAQEKALKRQLEEEQKL 1159
P + +P PLEE L P +P P+P PP + L E++ EE
Sbjct: 505 PPPESSPFSPLEESPLSPPEESP-PSPALETPLSPPPEASPLSPPFEESPLSPPPEELPT 563
Query: 1160 KPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALL 1219
P P +S SP P P PP EE+ P E +F + E+ L
Sbjct: 564 SP----PPEASRLSPPPEESPMSPPPEES----PMSPPPEASRLFPPFE------ESPLS 609
Query: 1220 DSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP 1260
E PL A L+ E SP ++P E++ +P P
Sbjct: 610 PPPEESPLSPPPEASRLSPPPEDSP--MSPPPEESPMSPPP 648
Score = 38.9 bits (89), Expect = 0.032
Identities = 44/152 (28%), Positives = 54/152 (35%), Gaps = 21/152 (13%)
Query: 1121 LEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARP 1180
++P P P G++L E L+ L EE L P P S SP P P
Sbjct: 404 MQPKEPGPLQCEAKPLGKAGVQL--EPQLEAPLNEEMPLLP----PPEESPLSPPPEESP 457
Query: 1181 GPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE----GPLPKETAAGGL 1236
PP E + R P E P S L EA L LE P P+E+
Sbjct: 458 TSPPPEAS---RLSPPPEELPA--------SPLPEALHLSRPLEESPLSPPPEESPLSPP 506
Query: 1237 TLKEERSPQTLAPVGEDAMKTPSPAAEDAREP 1268
SP +P+ PSPA E P
Sbjct: 507 PESSPFSPLEESPLSPPEESPPSPALETPLSP 538
Score = 32.7 bits (73), Expect = 2.3
Identities = 44/172 (25%), Positives = 61/172 (35%), Gaps = 22/172 (12%)
Query: 1100 ASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKL 1159
A G +P A P GP +L PA P QD GL A L
Sbjct: 2139 ADGFLKPPAGSVP-GPDSPGELFLKLPPQVPAQVPSQDPFGLAPAYP------------L 2185
Query: 1160 KPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALL 1219
+P AP + P PSP+ P PP A P PG F + + + +
Sbjct: 2186 EPRFPTAPPTYPPYPSPTGAPAQPPMLGA----SSRPGAGQPGEFHTTPPGTPRHQPSTP 2241
Query: 1220 DSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAK 1271
D L+ P+ + L + E SP + + +P P E + E K
Sbjct: 2242 DPFLK---PRCPSLDNLAVPE--SPGVGGGKASEPLLSPPPFGESRKALEVK 2288
Score = 32.3 bits (72), Expect = 3.0
Identities = 25/85 (29%), Positives = 29/85 (34%), Gaps = 2/85 (2%)
Query: 1106 PEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVG 1165
P +E P P E L P + P P P P +I A AL E E G
Sbjct: 910 PLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPII--TAAAPPALSPLGELEYPFGAKGDS 967
Query: 1166 APSSSSPSPSPSARPGPPPSEEAMD 1190
P S +P PPP D
Sbjct: 968 DPESPLAAPILETPISPPPEANCTD 992
Score = 31.6 bits (70), Expect = 5.1
Identities = 40/171 (23%), Positives = 58/171 (33%), Gaps = 45/171 (26%)
Query: 1060 QLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIM--------TILEASGKQEPEAKEA 1111
QL V K P+LR +P QQ + +M + + QEP + +
Sbjct: 4200 QLQGVLAKNPQLRH--------LSPQQQQQLQALLMQRQLQQSQAVRQTPPYQEPGTQTS 4251
Query: 1112 P------------------AGPLEEDDLEPLTLAPAPAPRPPQDL-IGLRLAQEKALKRQ 1152
P GPL+E P P P PP L G L
Sbjct: 4252 PLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGALSTGPVLGPVHPTPPP 4311
Query: 1153 LEEEQKLKPGGVGAPSSSSPSPS--PSARPGPPPSEEAMDFREEGPECETP 1201
++ +P + +PSS P+ + P PG P + +GP E P
Sbjct: 4312 SSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTP--------KPQGPTLEPP 4354
Score = 31.6 bits (70), Expect = 5.1
Identities = 29/88 (32%), Positives = 39/88 (44%), Gaps = 16/88 (18%)
Query: 1107 EAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGA 1166
+ ++ A P EE P LAP+PA P + L+ +L E +P V +
Sbjct: 4902 DVRQLSAPPPEEPSPPPSPLAPSPASPPTEPLV------------ELPTEPLAEP-PVPS 4948
Query: 1167 PSSSSPSPSPSARPGP--PPSEEAMDFR 1192
P + SP SARP P P EE D R
Sbjct: 4949 PLPLASSPE-SARPKPRARPPEEGEDSR 4975
Score = 31.2 bits (69), Expect = 6.6
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 1106 PEAKEAPAGPLEE-DDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGV 1164
P +E+P P E L PL + +P P + L E++ E +L P
Sbjct: 637 PPPEESPMSPPPEVSRLSPLPVVSRLSPPPEES--PLSPPPEESPTSPPPEASRLSP--- 691
Query: 1165 GAPSSSSPSPSPSARPGPPPSEEAM 1189
P S SP P P PP E+++
Sbjct: 692 -PPEDSPTSPPPEDSPASPPPEDSL 715
Score = 31.2 bits (69), Expect = 6.6
Identities = 41/160 (25%), Positives = 55/160 (34%), Gaps = 36/160 (22%)
Query: 1106 PEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVG 1165
P +++PA P ED L L L +P L EE +L P G
Sbjct: 700 PPPEDSPASPPPEDSLMSLPLEESPL-------------------LPLPEEPQLCPRSEG 740
Query: 1166 APSSSSP-SPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE 1224
S P P S RP P + P+ E P + + E L E
Sbjct: 741 PHLSPRPEEPHLSPRPEEPHLSPQAEEPHLSPQPEEPCL-------CAVPEEPHLSPQAE 793
Query: 1225 G----PLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSP 1260
G P P+E L L + L+PV E+ +P P
Sbjct: 794 GPHLSPQPEE-----LHLSPQTEEPHLSPVPEEPCLSPQP 828
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 43.5 bits (101), Expect = 0.001
Identities = 57/201 (28%), Positives = 79/201 (39%), Gaps = 56/201 (27%)
Query: 1070 ELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQE--PEAKEAPAGPLEEDDLEPLTLA 1127
E + LA RS Q +P S L AS E P++K P+ P P +
Sbjct: 425 EKEKSALARERSLKKRQS--LPASPRARLSASTASELSPKSKARPSSPSTSWH-RPASPC 481
Query: 1128 PAPAP------RPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVG---------------- 1165
P+P P +PP G + + ++R+ EE K P G
Sbjct: 482 PSPGPGHTLPPKPPSPR-GTTASPKGRVRRK--EEAKESPSAAGPEDKSQSKRRASNEKE 538
Query: 1166 --APSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSL 1223
AP+S +PSP+PS P PP E+ P ETP T+AA+L +S
Sbjct: 539 SAAPASPAPSPAPSPTPAPPQKEQ--------PPAETP------------TDAAVL-TSP 577
Query: 1224 EGPLPKETAA---GGLTLKEE 1241
P P T + G T +EE
Sbjct: 578 PAPAPPVTPSKPMAGTTDREE 598
Score = 32.0 bits (71), Expect = 3.9
Identities = 30/112 (26%), Positives = 41/112 (36%), Gaps = 20/112 (17%)
Query: 1161 PGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLD 1220
P V A + P PSP P PPP P + + D T A+ +
Sbjct: 14 PPAVVARTPPEPRPSPEGDPSPPP----------------PPMSALVPDTPPDTPPAMKN 57
Query: 1221 SSLEGPLPKE-TAAGGLTLKEERSPQTLAPVGEDAMKTPSPAA---EDAREP 1268
++ LP E + G PQ +P E + P+P A DAR P
Sbjct: 58 ATSSKQLPLEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPP 109
>gi|34335264 zinc finger, MYND-type containing 8 isoform c [Homo
sapiens]
Length = 1135
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 23/172 (13%)
Query: 1099 EASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQK 1158
E K EPE E G + D EP + P P P ++ ++ LK +K
Sbjct: 602 EQKSKNEPEDTEDKEGC--QMDKEPSAVKKKPKPTNPVEI-------KEELKSTSPASEK 652
Query: 1159 LKPGGVGAPSSSSPSP--SPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEA 1216
PG V +S P S A+P P P ++ + ++ E ++P + + +D DS
Sbjct: 653 ADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKD---ETDSPTVHLGLDSDS----- 704
Query: 1217 ALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREP 1268
+S L L E +G K ++ P+ +P + KTP + P
Sbjct: 705 ---ESELVIDL-GEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSP 752
Score = 31.6 bits (70), Expect = 5.1
Identities = 32/142 (22%), Positives = 57/142 (40%), Gaps = 11/142 (7%)
Query: 246 PAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHL 305
P + + T+ GS+ N+ R ++ + E++ P S +R +L+L
Sbjct: 496 PITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNL 555
Query: 306 LSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPN 365
++ S + Q I + D+ T A S+D+ K DS+ + N
Sbjct: 556 DKTIE---SCKAQLGINEISEDVYT-----AVEHSDSEDSEKSDSSDSEYISDDEQKSKN 607
Query: 366 LGEDDEDKD---LEPGPSGTSK 384
ED EDK+ ++ PS K
Sbjct: 608 EPEDTEDKEGCQMDKEPSAVKK 629
>gi|34335262 zinc finger, MYND-type containing 8 isoform a [Homo
sapiens]
Length = 1188
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 23/172 (13%)
Query: 1099 EASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQK 1158
E K EPE E G + D EP + P P P ++ ++ LK +K
Sbjct: 627 EQKSKNEPEDTEDKEGC--QMDKEPSAVKKKPKPTNPVEI-------KEELKSTSPASEK 677
Query: 1159 LKPGGVGAPSSSSPSP--SPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEA 1216
PG V +S P S A+P P P ++ + ++ E ++P + + +D DS
Sbjct: 678 ADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKD---ETDSPTVHLGLDSDS----- 729
Query: 1217 ALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREP 1268
+S L L E +G K ++ P+ +P + KTP + P
Sbjct: 730 ---ESELVIDL-GEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSP 777
Score = 31.6 bits (70), Expect = 5.1
Identities = 32/142 (22%), Positives = 57/142 (40%), Gaps = 11/142 (7%)
Query: 246 PAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHL 305
P + + T+ GS+ N+ R ++ + E++ P S +R +L+L
Sbjct: 521 PITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNL 580
Query: 306 LSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPN 365
++ S + Q I + D+ T A S+D+ K DS+ + N
Sbjct: 581 DKTIE---SCKAQLGINEISEDVYT-----AVEHSDSEDSEKSDSSDSEYISDDEQKSKN 632
Query: 366 LGEDDEDKD---LEPGPSGTSK 384
ED EDK+ ++ PS K
Sbjct: 633 EPEDTEDKEGCQMDKEPSAVKK 654
>gi|34335266 zinc finger, MYND-type containing 8 isoform b [Homo
sapiens]
Length = 1160
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/172 (25%), Positives = 70/172 (40%), Gaps = 23/172 (13%)
Query: 1099 EASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQK 1158
E K EPE E G + D EP + P P P ++ ++ LK +K
Sbjct: 627 EQKSKNEPEDTEDKEGC--QMDKEPSAVKKKPKPTNPVEI-------KEELKSTSPASEK 677
Query: 1159 LKPGGVGAPSSSSPSP--SPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEA 1216
PG V +S P S A+P P P ++ + ++ E ++P + + +D DS
Sbjct: 678 ADPGAVKDKASPEPEKDFSEKAKPSPHPIKDKLKGKD---ETDSPTVHLGLDSDS----- 729
Query: 1217 ALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREP 1268
+S L L E +G K ++ P+ +P + KTP + P
Sbjct: 730 ---ESELVIDL-GEDHSGREGRKNKKEPKEPSPKQDVVGKTPPSTTVGSHSP 777
Score = 31.6 bits (70), Expect = 5.1
Identities = 32/142 (22%), Positives = 57/142 (40%), Gaps = 11/142 (7%)
Query: 246 PAISSINLTTALGSLANIARQRPMFMSEVIQAYETLHANLPPTLAKSQVSSVRKNLKLHL 305
P + + T+ GS+ N+ R ++ + E++ P S +R +L+L
Sbjct: 521 PITTKTDKTSTTGSILNLNLDRSKAEMDLKELSESVQQQSTPVPLISPKRQIRSRFQLNL 580
Query: 306 LSVLKHPASLEFQAQITTLLVDLGTPQAEIARNMPSSKDTRKRPRDDSDSTLKKMKLEPN 365
++ S + Q I + D+ T A S+D+ K DS+ + N
Sbjct: 581 DKTIE---SCKAQLGINEISEDVYT-----AVEHSDSEDSEKSDSSDSEYISDDEQKSKN 632
Query: 366 LGEDDEDKD---LEPGPSGTSK 384
ED EDK+ ++ PS K
Sbjct: 633 EPEDTEDKEGCQMDKEPSAVKK 654
>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
[Homo sapiens]
Length = 1481
Score = 42.4 bits (98), Expect = 0.003
Identities = 41/166 (24%), Positives = 60/166 (36%), Gaps = 21/166 (12%)
Query: 1037 GFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMT 1096
G Q+ V+L L Q P++ + L H Q + SI
Sbjct: 1103 GLADITQQLNQSELAVLLNLLQSQTDL---SIPQMAQLLNIHSNPEMQQQLEALNQSISA 1159
Query: 1097 ILEASGKQ--------EPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKA 1148
+ EA+ +Q E KEAP+ P+ E TL + P Q+++ + L+Q
Sbjct: 1160 LTEATSQQQDSETMAPEESLKEAPSAPVILPSAEQTTLEASSTPADMQNILAVLLSQLMK 1219
Query: 1149 LKR---QLEEEQKLKPGGVGAPSSSSPSPS-------PSARPGPPP 1184
+ LEE K G P + P P PGPPP
Sbjct: 1220 TQEPAGSLEENNSDKNSGPQGPRRTPTMPQEEAAEKRPPEPPGPPP 1265
>gi|239755545 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2852
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1604 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1657
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1658 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1714
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1715 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1768
Query: 1266 REP 1268
P
Sbjct: 1769 TTP 1771
>gi|239755543 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2924
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1676 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1729
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1730 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1786
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1787 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1840
Query: 1266 REP 1268
P
Sbjct: 1841 TTP 1843
>gi|239749989 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2852
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1604 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1657
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1658 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1714
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1715 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1768
Query: 1266 REP 1268
P
Sbjct: 1769 TTP 1771
>gi|239749987 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2924
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1676 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1729
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1730 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1786
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1787 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1840
Query: 1266 REP 1268
P
Sbjct: 1841 TTP 1843
>gi|239744300 PREDICTED: otogelin isoform 2 [Homo sapiens]
Length = 2852
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1604 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1657
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1658 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1714
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1715 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1768
Query: 1266 REP 1268
P
Sbjct: 1769 TTP 1771
>gi|239744298 PREDICTED: otogelin isoform 1 [Homo sapiens]
Length = 2924
Score = 40.8 bits (94), Expect = 0.008
Identities = 51/183 (27%), Positives = 75/183 (40%), Gaps = 16/183 (8%)
Query: 1087 QAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQE 1146
+A + ++ ++ +G +P ++ + P PLT+A A + P + R + E
Sbjct: 1676 KAVLTPAVTKVISRTGVPQPTQAQSASSPST-----PLTVAGTAAEQVPVSPLATR-SLE 1729
Query: 1147 KALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFIS 1206
L + E +P +G+P+S P P PSA P P M R ETP
Sbjct: 1730 IVLSTEKGEAGHSQP--MGSPASPQPHPLPSA-PPRPAQHTTMATRSPALPPETPAAASL 1786
Query: 1207 MDDDSGLTEAALLDSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDA-MKTPSPAAEDA 1265
GL AA SLE P + +G L + S LA VG A + TP P A
Sbjct: 1787 STATDGL--AATPFMSLESTRPSQLLSG---LPPDTS-LPLAKVGTSAPVATPGPKASVI 1840
Query: 1266 REP 1268
P
Sbjct: 1841 TTP 1843
>gi|148806884 AKT1 substrate 1 (proline-rich) [Homo sapiens]
Length = 256
Score = 40.8 bits (94), Expect = 0.008
Identities = 57/188 (30%), Positives = 76/188 (40%), Gaps = 33/188 (17%)
Query: 1100 ASGKQEPEAKEAPAGPLEE------DDLEPLTLAPAPAPRPPQDLIGL--RLAQEKALKR 1151
ASG+ E E EA G E +L LT AP P PRP R A +A +R
Sbjct: 2 ASGRPE-ELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR 60
Query: 1152 QLEEEQKLKPGGVGA------PSSSSPSPSPSARPGPPPSEEAMDFREEGP-ECETPGIF 1204
L + A P+ PSP+PS P P + E + E+ P E ET G
Sbjct: 61 CLHDIALAHRAATAARPPAPPPAPQPPSPTPSP-PRPTLAREDNEEDEDEPTETETSGEQ 119
Query: 1205 ISMDDDSGL----TEAALLD----------SSLEGPLPKETAAGGLTLKEERSPQTLAPV 1250
+ + D+ GL +A L D S+ +G L +ET AG T P + P
Sbjct: 120 LGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSV--PPASALPT 177
Query: 1251 GEDAMKTP 1258
+ A P
Sbjct: 178 QQYAKSLP 185
>gi|148806906 AKT1 substrate 1 (proline-rich) [Homo sapiens]
Length = 256
Score = 40.8 bits (94), Expect = 0.008
Identities = 57/188 (30%), Positives = 76/188 (40%), Gaps = 33/188 (17%)
Query: 1100 ASGKQEPEAKEAPAGPLEE------DDLEPLTLAPAPAPRPPQDLIGL--RLAQEKALKR 1151
ASG+ E E EA G E +L LT AP P PRP R A +A +R
Sbjct: 2 ASGRPE-ELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR 60
Query: 1152 QLEEEQKLKPGGVGA------PSSSSPSPSPSARPGPPPSEEAMDFREEGP-ECETPGIF 1204
L + A P+ PSP+PS P P + E + E+ P E ET G
Sbjct: 61 CLHDIALAHRAATAARPPAPPPAPQPPSPTPSP-PRPTLAREDNEEDEDEPTETETSGEQ 119
Query: 1205 ISMDDDSGL----TEAALLD----------SSLEGPLPKETAAGGLTLKEERSPQTLAPV 1250
+ + D+ GL +A L D S+ +G L +ET AG T P + P
Sbjct: 120 LGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSV--PPASALPT 177
Query: 1251 GEDAMKTP 1258
+ A P
Sbjct: 178 QQYAKSLP 185
>gi|148806896 AKT1 substrate 1 (proline-rich) [Homo sapiens]
Length = 256
Score = 40.8 bits (94), Expect = 0.008
Identities = 57/188 (30%), Positives = 76/188 (40%), Gaps = 33/188 (17%)
Query: 1100 ASGKQEPEAKEAPAGPLEE------DDLEPLTLAPAPAPRPPQDLIGL--RLAQEKALKR 1151
ASG+ E E EA G E +L LT AP P PRP R A +A +R
Sbjct: 2 ASGRPE-ELWEAVVGAAERFRARTGTELVLLTAAPPPPPRPGPCAYAAHGRGALAEAARR 60
Query: 1152 QLEEEQKLKPGGVGA------PSSSSPSPSPSARPGPPPSEEAMDFREEGP-ECETPGIF 1204
L + A P+ PSP+PS P P + E + E+ P E ET G
Sbjct: 61 CLHDIALAHRAATAARPPAPPPAPQPPSPTPSP-PRPTLAREDNEEDEDEPTETETSGEQ 119
Query: 1205 ISMDDDSGL----TEAALLD----------SSLEGPLPKETAAGGLTLKEERSPQTLAPV 1250
+ + D+ GL +A L D S+ +G L +ET AG T P + P
Sbjct: 120 LGISDNGGLFVMDEDATLQDLPPFCESDPESTDDGSLSEETPAGPPTCSV--PPASALPT 177
Query: 1251 GEDAMKTP 1258
+ A P
Sbjct: 178 QQYAKSLP 185
>gi|4503179 oral-facial-digital syndrome 1 [Homo sapiens]
Length = 1012
Score = 40.4 bits (93), Expect = 0.011
Identities = 58/252 (23%), Positives = 101/252 (40%), Gaps = 37/252 (14%)
Query: 1018 NILSRLIMKQVWKYPKVW------EGFIKCCQRTKPQSFQVILQLPPQQLGAVFDKCPE- 1070
N+L+R++ ++ YP W + ++ TK + + LQ ++L F
Sbjct: 598 NVLARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKE--LQQEAERLEKAFRSYHRR 655
Query: 1071 -LREPLLAHVRSFTPHQQAHIPNSIMTILEAS------GKQEPEAKEAPAGPLEE--DDL 1121
++ + + + +P H+ + I +S G+ +++ G LEE D +
Sbjct: 656 VIKNSAKSPLAAKSP-PSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVV 714
Query: 1122 EPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPG 1181
E LT + A R L KR LE E L+ G+G +SPSP P P
Sbjct: 715 EALTGSAASRLRGGTSSRRLSSTPLPKAKRSLESEMYLE--GLGRSHIASPSPCPDRMPL 772
Query: 1182 PPPSEEAMDFR---EEGPECETPGIF---ISMDDDSGLTEAALL--------DSSLE--G 1225
P P+E P + G++ + D S ++ L +SS E G
Sbjct: 773 PSPTESRHSLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAG 832
Query: 1226 PLPKETAAGGLT 1237
+P++ GGL+
Sbjct: 833 NMPRQLEMGGLS 844
>gi|222537747 hypothetical protein LOC342979 [Homo sapiens]
Length = 673
Score = 40.0 bits (92), Expect = 0.014
Identities = 28/98 (28%), Positives = 45/98 (45%), Gaps = 3/98 (3%)
Query: 1103 KQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPG 1162
K+ P+ +E P G LEE+ ++P T A P + LA+ A ++ E + L+
Sbjct: 572 KEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPL---LAETPAPEQPAECQPLLQGE 628
Query: 1163 GVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECET 1200
G A S+ P P+ + P PS GP+ +T
Sbjct: 629 GPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKT 666
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 40.0 bits (92), Expect = 0.014
Identities = 40/165 (24%), Positives = 61/165 (36%), Gaps = 12/165 (7%)
Query: 1083 TPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLR 1142
TP + P + ++G P G +E +P P P+P P
Sbjct: 855 TPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQP---GPTPSPGPNSGASRRS 911
Query: 1143 LAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPG 1202
A + A R L EE+ L+ GG + SPS+ P P ++ + PE
Sbjct: 912 SASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPSSLPRSSPEAVVREWLDNIPEEPILM 971
Query: 1203 IFISMDDDSGLTEAALL--------DSSLEGPLPKETAAGGLTLK 1239
+ D+ +G L D SLEG L + AG +L+
Sbjct: 972 TYELADETTGAAGGGLRGPEVDPGDDHSLEG-LGEPAQAGQQSLE 1015
Score = 35.8 bits (81), Expect = 0.27
Identities = 51/234 (21%), Positives = 82/234 (35%), Gaps = 30/234 (12%)
Query: 1058 PQQLGAVFDKCPELREPLLAHVRSFTPHQQAHIPNSIMTILEASGKQEPEAKEAPAGPLE 1117
P+ G + E +P L V + +A + + EA G+ +PE + A E
Sbjct: 2159 PESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAE 2218
Query: 1118 EDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPG--------GVGAPSS 1169
E+ +P + + A+ +A E Q K G G +S
Sbjct: 2219 EE------------AQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEAS 2266
Query: 1170 SSPSPSPSARPGPPPS-----EEAMDFREEGPECETPGIF-----ISMDDDSGLTEAALL 1219
S SP P RP PPPS + GP + ++D L +
Sbjct: 2267 ESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSP 2326
Query: 1220 DSSLEGPLPKETAAGGLTLKEERSPQTLAPVGEDAMKTPSPAAEDAREPEAKGN 1273
D+ G E A + + S Q AP+G + + D +E +A G+
Sbjct: 2327 DAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGS 2380
Score = 30.8 bits (68), Expect = 8.6
Identities = 39/195 (20%), Positives = 71/195 (36%), Gaps = 9/195 (4%)
Query: 1086 QQAHIPNSIMTILEASGKQEPEAKEAPAGPLEE----DDLEPLTLAPAPAPRPPQDLIGL 1141
+ P + + EA + +PE+ A P E ++E T +P D +
Sbjct: 1998 EDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEA 2057
Query: 1142 RLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETP 1201
A+E+A + + E ++ G P S + P SE EG +
Sbjct: 2058 PEAEEEAQEAEGEVQEA---EGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114
Query: 1202 GIFISMDDDSGLTEAALLDS-SLEGPL-PKETAAGGLTLKEERSPQTLAPVGEDAMKTPS 1259
GI + E+ +++ EG P+ + E P++ ++A +
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174
Query: 1260 PAAEDAREPEAKGNS 1274
P E PEA+G +
Sbjct: 2175 PELEGVEAPEAEGEA 2189
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/124 (28%), Positives = 48/124 (38%), Gaps = 13/124 (10%)
Query: 1105 EPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGV 1164
+P++ + +GP+ + P PAP P P I + + A L Q L P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP--GPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPP- 673
Query: 1165 GAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE 1224
G P SS+P P PG PP + P +S D L L S +E
Sbjct: 674 GLPGSSTPGVLPYFPPGLPPPDAG----------GAPQSSMSESPDVNLVTQQLSKSQVE 723
Query: 1225 GPLP 1228
PLP
Sbjct: 724 DPLP 727
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/124 (28%), Positives = 48/124 (38%), Gaps = 13/124 (10%)
Query: 1105 EPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGV 1164
+P++ + +GP+ + P PAP P P I + + A L Q L P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP--GPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPP- 673
Query: 1165 GAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE 1224
G P SS+P P PG PP + P +S D L L S +E
Sbjct: 674 GLPGSSTPGVLPYFPPGLPPPDAG----------GAPQSSMSESPDVNLVTQQLSKSQVE 723
Query: 1225 GPLP 1228
PLP
Sbjct: 724 DPLP 727
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/124 (28%), Positives = 48/124 (38%), Gaps = 13/124 (10%)
Query: 1105 EPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGV 1164
+P++ + +GP+ + P PAP P P I + + A L Q L P
Sbjct: 617 QPQSAGSTSGPVPQPACPPP--GPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPP- 673
Query: 1165 GAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE 1224
G P SS+P P PG PP + P +S D L L S +E
Sbjct: 674 GLPGSSTPGVLPYFPPGLPPPDAG----------GAPQSSMSESPDVNLVTQQLSKSQVE 723
Query: 1225 GPLP 1228
PLP
Sbjct: 724 DPLP 727
>gi|20986499 mitogen-activated protein kinase 7 isoform 2 [Homo
sapiens]
Length = 677
Score = 39.7 bits (91), Expect = 0.019
Identities = 35/124 (28%), Positives = 48/124 (38%), Gaps = 13/124 (10%)
Query: 1105 EPEAKEAPAGPLEEDDLEPLTLAPAPAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGV 1164
+P++ + +GP+ + P PAP P P I + + A L Q L P
Sbjct: 478 QPQSAGSTSGPVPQPACPPP--GPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPP- 534
Query: 1165 GAPSSSSPSPSPSARPGPPPSEEAMDFREEGPECETPGIFISMDDDSGLTEAALLDSSLE 1224
G P SS+P P PG PP + P +S D L L S +E
Sbjct: 535 GLPGSSTPGVLPYFPPGLPPPDAG----------GAPQSSMSESPDVNLVTQQLSKSQVE 584
Query: 1225 GPLP 1228
PLP
Sbjct: 585 DPLP 588
>gi|40556370 PHD finger protein 15 [Homo sapiens]
Length = 790
Score = 39.7 bits (91), Expect = 0.019
Identities = 38/136 (27%), Positives = 52/136 (38%), Gaps = 6/136 (4%)
Query: 1130 PAPRPPQDLIGLRLAQEKALKRQLEEEQKLKPGGVGAPSSSSPSPSPSARPGPPPSEEAM 1189
P P PPQD G R +KA K+ ++ GG G P+ P + S P P + +
Sbjct: 606 PPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPAAGDCP 665
Query: 1190 DFREEGPECETPGIFISMDDDSGLTEAALLDSSLEGPLPKETAAGGL-TLKEERSPQTLA 1248
E+P D + AA D + GP G L +E + + L
Sbjct: 666 ILATP----ESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRLP 721
Query: 1249 PVGEDA-MKTPSPAAE 1263
DA M PS AE
Sbjct: 722 GARPDAGMGPPSAVAE 737
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 39.3 bits (90), Expect = 0.024
Identities = 19/56 (33%), Positives = 31/56 (55%), Gaps = 1/56 (1%)
Query: 833 GMGMNSPELLLLVENCPKGAETLVTRCLHSLTDKVPPSPELVKRVRDLYHKRLPDV 888
G G SP+L L +NCPK + LV C+ + ++ P P+++ + L H LP +
Sbjct: 562 GRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHS-LPKI 616
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,487,963
Number of Sequences: 37866
Number of extensions: 2505709
Number of successful extensions: 17612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 415
Number of HSP's that attempted gapping in prelim test: 15611
Number of HSP's gapped (non-prelim): 2104
length of query: 1274
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1160
effective length of database: 13,930,794
effective search space: 16159721040
effective search space used: 16159721040
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.