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Search of human proteins with 122937470
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo
sapiens]
(545 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 1107 0.0
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 216 3e-56
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 216 3e-56
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 187 2e-47
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 184 2e-46
gi|4759146 slit homolog 2 [Homo sapiens] 164 1e-40
gi|11321571 slit homolog 3 [Homo sapiens] 164 2e-40
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 162 6e-40
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 159 8e-39
gi|225579152 insulin-like growth factor binding protein, acid la... 158 1e-38
gi|4826772 insulin-like growth factor binding protein, acid labi... 158 1e-38
gi|198041768 synleurin [Homo sapiens] 157 2e-38
gi|188528675 slit homolog 1 [Homo sapiens] 157 2e-38
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 156 4e-38
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 155 1e-37
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 153 3e-37
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 149 8e-36
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 145 1e-34
gi|194440719 chondroadherin-like [Homo sapiens] 142 1e-33
gi|7019381 fibronectin leucine rich transmembrane protein 2 [Hom... 141 1e-33
gi|156139147 leucine rich repeat transmembrane neuronal 4 isofor... 140 4e-33
gi|197927168 leucine rich repeat transmembrane neuronal 4 isofor... 140 4e-33
gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo sa... 138 1e-32
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 137 3e-32
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 135 1e-31
gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens] 134 2e-31
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 134 3e-31
gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo s... 130 3e-30
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 129 7e-30
gi|12007646 nyctalopin precursor [Homo sapiens] 129 9e-30
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 1107 bits (2864), Expect = 0.0
Identities = 545/545 (100%), Positives = 545/545 (100%)
Query: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS 60
MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS
Sbjct: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS 60
Query: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL
Sbjct: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
Query: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL
Sbjct: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
Query: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL
Sbjct: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
Query: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ
Sbjct: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
Query: 301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL 360
LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL
Sbjct: 301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL 360
Query: 361 SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI 420
SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI
Sbjct: 361 SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI 420
Query: 421 QTYCAGPAYLKGQVVPALNEKQLVCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQ 480
QTYCAGPAYLKGQVVPALNEKQLVCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQ
Sbjct: 421 QTYCAGPAYLKGQVVPALNEKQLVCPVTRDHLGFQVTWPDESKAGGSWDLAVQERAARSQ 480
Query: 481 CTYSNPEGTVVLACDQAQCRWLNVQLSPWQGSLGLQYNASQEWDLRSSCGSLRLTVSIEA 540
CTYSNPEGTVVLACDQAQCRWLNVQLSPWQGSLGLQYNASQEWDLRSSCGSLRLTVSIEA
Sbjct: 481 CTYSNPEGTVVLACDQAQCRWLNVQLSPWQGSLGLQYNASQEWDLRSSCGSLRLTVSIEA 540
Query: 541 RAAGP 545
RAAGP
Sbjct: 541 RAAGP 545
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 216 bits (551), Expect = 3e-56
Identities = 148/444 (33%), Positives = 213/444 (47%), Gaps = 26/444 (5%)
Query: 22 CPMGCDCF-VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVF 80
CP C C +V C+ + VP +P ++ + T T L F + L +
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 90
Query: 81 LNTQLCQFRPDAFG------------------------GLPRLEDLEVTGSSFLNLSTNI 116
+L + P AF GL LE L ++ + L +
Sbjct: 91 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 150
Query: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNL 176
FS ++L +L L+ N LE +P+G F HL L L+L N L + R+FQ L +L+ L L
Sbjct: 151 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 210
Query: 177 AQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV 236
+N L +P F L +LQ L L N + L G+F +LQ L+L +N+IS+LPP +
Sbjct: 211 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 270
Query: 237 FSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSL 296
F QL L RL L N++ L L IF + NL L L N + LP +F++ L L L
Sbjct: 271 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 330
Query: 297 THNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
+ NQ+ ++ G F L+ LR L L NA+ L +FR L L + L +N L L +
Sbjct: 331 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 390
Query: 357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDR 416
F N++ L + L NQL LP GIFD L L L+ NPW+CD + L NWL R
Sbjct: 391 FANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPR 450
Query: 417 L-LNIQTYCAGPAYLKGQVVPALN 439
L + C PA ++GQ + +N
Sbjct: 451 LGTDTVPVCFSPANVRGQSLIIIN 474
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 216 bits (551), Expect = 3e-56
Identities = 148/444 (33%), Positives = 213/444 (47%), Gaps = 26/444 (5%)
Query: 22 CPMGCDCF-VQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVF 80
CP C C +V C+ + VP +P ++ + T T L F + L +
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRI 84
Query: 81 LNTQLCQFRPDAFG------------------------GLPRLEDLEVTGSSFLNLSTNI 116
+L + P AF GL LE L ++ + L +
Sbjct: 85 EKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAH 144
Query: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNL 176
FS ++L +L L+ N LE +P+G F HL L L+L N L + R+FQ L +L+ L L
Sbjct: 145 FSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRL 204
Query: 177 AQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV 236
+N L +P F L +LQ L L N + L G+F +LQ L+L +N+IS+LPP +
Sbjct: 205 YENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSI 264
Query: 237 FSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSL 296
F QL L RL L N++ L L IF + NL L L N + LP +F++ L L L
Sbjct: 265 FMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLIL 324
Query: 297 THNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
+ NQ+ ++ G F L+ LR L L NA+ L +FR L L + L +N L L +
Sbjct: 325 SRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNI 384
Query: 357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDR 416
F N++ L + L NQL LP GIFD L L L+ NPW+CD + L NWL R
Sbjct: 385 FANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQPR 444
Query: 417 L-LNIQTYCAGPAYLKGQVVPALN 439
L + C PA ++GQ + +N
Sbjct: 445 LGTDTVPVCFSPANVRGQSLIIIN 468
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 187 bits (476), Expect = 2e-47
Identities = 152/500 (30%), Positives = 212/500 (42%), Gaps = 75/500 (15%)
Query: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVF-CSDEELATVPLDIPPYTKNIIFVET 59
ML G L LL A+P PCP C C ++ CS ++A +
Sbjct: 1 MLRGTLLCAVLGLLRAQPF-PCPPACKCVFRDAAQCSGGDVARIS--------------- 44
Query: 60 SFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSN 119
A G NLT ++ + +F G+ L+ L ++ S ++ FS+
Sbjct: 45 --------ALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSD 96
Query: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179
L L L L+ N + LP L + LE L L N L+ + + +FQ L +L+ L L QN
Sbjct: 97 LIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQN 156
Query: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239
L LP LF L +L+ L LS N L+ LP+G+ G L+ L L SN + L + +
Sbjct: 157 QLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNS 216
Query: 240 LFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299
L L L RN I + F L NL+ L+L N L LP+ LF H+ L L+L N
Sbjct: 217 LGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFEN 276
Query: 300 -------------------------------------------------QLETVAEGTFA 310
+L + +G F
Sbjct: 277 PLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQ 336
Query: 311 HLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSK 370
L L+ L L N +T LP G+ R L +L ++ L N L AL ALF+NLS LE + L
Sbjct: 337 GLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDH 396
Query: 371 NQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ-TYCAGPAY 429
NQL TLP +F L + L N W+CDC L WL+Q+ + + CAGP
Sbjct: 397 NQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGA 456
Query: 430 LKGQVVPALNEKQLVCPVTR 449
G + AL CP R
Sbjct: 457 HAGLPLWALPGGDAECPGPR 476
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 184 bits (467), Expect = 2e-46
Identities = 128/342 (37%), Positives = 172/342 (50%), Gaps = 4/342 (1%)
Query: 106 GSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLF 165
G+ N++ F L L +L L +N + +L F+ L+ LE L+L N LQAL
Sbjct: 68 GNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTL 127
Query: 166 QPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLD 225
PL L+ L N +++L F L SL L+L NAL LP VF LG+L L L+
Sbjct: 128 APLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLE 187
Query: 226 SNNISELPPQVFSQLFCLERLWLQRNAI--THLPLSIFASLGNLTFLSLQWNMLRVLPAG 283
SN I L F+QL L L L N + + + FA L +L+ L L N L+ L
Sbjct: 188 SNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPR 247
Query: 284 LFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLY 343
+F H P L LSL NQL +A F L LR L L N ++ LP + L L L
Sbjct: 248 IFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALD 307
Query: 344 LGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHL 403
L N L+ALHPA F +L +L LSL N L+ L IF + L+ L L GN W CDC L
Sbjct: 308 LSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRL 367
Query: 404 AYLFNWLQQY--TDRLLNIQTYCAGPAYLKGQVVPALNEKQL 443
L W+ + RLL + C P L+G+ + L+++QL
Sbjct: 368 RGLKRWMGDWHSQGRLLTVFVQCRHPPALRGKYLDYLDDQQL 409
Score = 83.6 bits (205), Expect = 4e-16
Identities = 59/180 (32%), Positives = 85/180 (47%), Gaps = 5/180 (2%)
Query: 53 NIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPD-----AFGGLPRLEDLEVTGS 107
N++++ + + L K+ FLN + +P F L L L ++ +
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
Query: 108 SFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQP 167
+ +L IF +L LG L+L N L L F L AL L L+GN+L LP L +P
Sbjct: 240 NLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEP 299
Query: 168 LTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSN 227
L L+ L+L+ N L+ L F L L+ L L NNALS L +F +L L LD N
Sbjct: 300 LHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 164 bits (416), Expect = 1e-40
Identities = 121/431 (28%), Positives = 200/431 (46%), Gaps = 26/431 (6%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V C + L +P ++P I + + + AF L ++
Sbjct: 273 CPAACTCSNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLS 332
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
N Q+ + PDAF GL L L + G+ L ++F L SL L LN N + L F
Sbjct: 333 NNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAF 392
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL------LAQLPEELF-HPLTS 194
Q L L L L N+LQ + + F PL ++T++LAQN L L + L +P+ +
Sbjct: 393 QDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIET 452
Query: 195 -----LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNI--SELPPQVFSQLFCLERLW 247
+L+N + + F + + ++ F+ S+L F+ L C E+
Sbjct: 453 SGARCTSPRRLANKRIGQIKSKKF-RCSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCR 511
Query: 248 LQRNAI-------THLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
+ + +P I L + ++ +L G+F P L ++ ++N+
Sbjct: 512 CEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEA--TGIFKKLPQLRKINFSNNK 569
Query: 301 LETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNL 360
+ + EG F S + ++L+ N + ++ +F+ LE L L L SN +T + F L
Sbjct: 570 ITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGL 629
Query: 361 SKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNI 420
S + LLSL NQ+TT+ G FDT ++L L L NP+ C+C+LA+L WL++ R++
Sbjct: 630 SSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK--KRIVTG 687
Query: 421 QTYCAGPAYLK 431
C P +LK
Sbjct: 688 NPRCQKPYFLK 698
Score = 157 bits (396), Expect = 3e-38
Identities = 140/532 (26%), Positives = 218/532 (40%), Gaps = 90/532 (16%)
Query: 20 QPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVV 79
Q CP C C V C L +VP +IP T+ + + N+T++
Sbjct: 26 QACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERLDL--------------NGNNITRIT 71
Query: 80 FLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEG 139
+ F GL L L++ + + F +L L +L LN N L+ PE
Sbjct: 72 KTD----------FAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPEL 121
Query: 140 LFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLK 199
LF A L L L NQ+QA+PR+ F+ +K L L N ++ + + F L L+ L
Sbjct: 122 LFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLT 181
Query: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNIS------------ELPPQVFSQLFCLERLW 247
L+NN ++ L F + L+ L SNN+ P+V C+
Sbjct: 182 LNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSH 241
Query: 248 LQRNAITHLPLSIFASLGNLTFLS------------------------------------ 271
L+ + + + F G+ +F++
Sbjct: 242 LRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPET 301
Query: 272 -----LQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326
L+ N ++V+P G F+ L + L++NQ+ +A F L +L SL+L N IT
Sbjct: 302 ITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKIT 361
Query: 327 HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYN 386
LP +F L L L L +N + L FQ+L L LLSL N+L T+ +G F
Sbjct: 362 ELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLRA 421
Query: 387 LFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
+ + L NP+ CDCHL +L ++L +T+ + C P L + + + K+ C
Sbjct: 422 IQTMHLAQNPFICDCHLKWLADYL--HTNPIETSGARCTSPRRLANKRIGQIKSKKFRCS 479
Query: 447 VTRDHLGFQVTWPDESKAGGSW--DLAVQERAARSQCTYSNPEGTVVLACDQ 496
+ T SK G DLA E+ +C EGT V +Q
Sbjct: 480 AKEQYF-IPGTEDYRSKLSGDCFADLACPEKC---RC-----EGTTVDCSNQ 522
Score = 117 bits (293), Expect = 3e-26
Identities = 112/456 (24%), Positives = 184/456 (40%), Gaps = 86/456 (18%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V CS+++L +P IP YT + FT LE
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLE---------------- 549
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
+T IF L L K+ + N + + EG F
Sbjct: 550 -------------------------------ATGIFKKLPQLRKINFSNNKITDIEEGAF 578
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLS 201
+ + + + L N+L+ + ++F+ L LKTL L N + + + F L+S++ L L
Sbjct: 579 EGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLY 638
Query: 202 NNALSGLPQGVFGKLGSLQELFLDSNNIS------------ELPPQVFSQLFCLERLWLQ 249
+N ++ + G F L SL L L +N + V C + +L+
Sbjct: 639 DNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLK 698
Query: 250 RNAITHLPLSIFA--------SLGNL-----------TFLSLQWNMLRVLPAGLFAHTPC 290
I + + F S L T + L+VLP G+
Sbjct: 699 EIPIQDVAIQDFTCDDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRD--- 755
Query: 291 LVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLT 350
+ L L NQ T+ ++ +L + LS N I+ L F ++ +L+ L L N L
Sbjct: 756 VTELYLDGNQF-TLVPKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLR 814
Query: 351 ALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWL 410
+ P F L L LLSL N ++ +PEG F+ L +LA+ NP CDC++ +L +W+
Sbjct: 815 CIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWV 874
Query: 411 Q-QYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
+ +Y + + CAGP + +++ K+ C
Sbjct: 875 KSEYKEPGI---ARCAGPGEMADKLLLTTPSKKFTC 907
Score = 58.9 bits (141), Expect = 1e-08
Identities = 42/164 (25%), Positives = 61/164 (37%), Gaps = 25/164 (15%)
Query: 18 PAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
P CP C C V CS++ L +P IP + FT +
Sbjct: 723 PLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLV------------- 769
Query: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALP 137
P L ++++ + LS FSN+T L L L++N L +P
Sbjct: 770 ------------PKELSNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIP 817
Query: 138 EGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
F L +L L L GN + +P F L+ L L + N L
Sbjct: 818 PRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSHLAIGANPL 861
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 164 bits (415), Expect = 2e-40
Identities = 129/435 (29%), Positives = 195/435 (44%), Gaps = 42/435 (9%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V C + L +P ++P I + S + AF L ++
Sbjct: 280 CPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLKRIDIS 339
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
Q+ PDAF GL L L + G+ ++ +F L SL L LN N + L F
Sbjct: 340 KNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNANKINCLRVNTF 399
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN-------------LLAQLPEEL 188
Q L L L L N+LQ + + LF PL ++TL+LAQN L P E
Sbjct: 400 QDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIET 459
Query: 189 FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWL 248
S +L+N +S + F GS + S + F L C E+
Sbjct: 460 SGARCS-SPRRLANKRISQIKSKKFRCSGS-------EDYRSRFSSECFMDLVCPEKCRC 511
Query: 249 QRNAI-----------THLPLSIFASLGNLTFLSLQWNMLRVLPA-GLFAHTPCLVGLSL 296
+ + +HLP + T L L N + VL A G+F P L ++L
Sbjct: 512 EGTIVDCSNQKLVRIPSHLPEYV-------TDLRLNDNEVSVLEATGIFKKLPNLRKINL 564
Query: 297 THNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPAL 356
++N+++ V EG F ++++ LML+ N + + +FR L L L L SN + +
Sbjct: 565 SNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDT 624
Query: 357 FQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDR 416
F LS + LLSL N++TT+ G F T +L + L NP+ C+CHLA+L WL++ R
Sbjct: 625 FAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK--RR 682
Query: 417 LLNIQTYCAGPAYLK 431
+++ C P +LK
Sbjct: 683 IVSGNPRCQKPFFLK 697
Score = 145 bits (365), Expect = 1e-34
Identities = 113/469 (24%), Positives = 197/469 (42%), Gaps = 32/469 (6%)
Query: 13 LLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSN 72
+L PA CP C C V C L VP IP + + + T + F
Sbjct: 25 VLSGPPAVACPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGL 84
Query: 73 PNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
NL + + Q+ AF L +LE L + + L +F + L +L L+ N
Sbjct: 85 KNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLDLSENQ 144
Query: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
++ +P F+ + +++L L N + + F+ L L+ L L N ++++ F+ +
Sbjct: 145 IQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHM 204
Query: 193 TSLQTLKLSNN--------------------------ALSGLPQGVFGKLGSLQELFLDS 226
++TL+L +N ++ + F ++ ++
Sbjct: 205 PKIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVADVQKKEYVCP 264
Query: 227 NNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL----TFLSLQWNMLRVLPA 282
SE P + + C N + + NL + L+ N ++ +PA
Sbjct: 265 APHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPA 324
Query: 283 GLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKL 342
G F L + ++ NQ+ +A F L +L SL+L N IT + G+F L L L
Sbjct: 325 GAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLL 384
Query: 343 YLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCH 402
L +N + L FQ+L L LLSL N+L T+ +G+F ++ L L NP+ CDCH
Sbjct: 385 LLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCH 444
Query: 403 LAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCPVTRDH 451
L +L ++LQ + + C+ P L + + + K+ C + D+
Sbjct: 445 LKWLADYLQD--NPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDY 491
Score = 118 bits (295), Expect = 2e-26
Identities = 112/420 (26%), Positives = 174/420 (41%), Gaps = 81/420 (19%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V CS+++L +P +P Y ++
Sbjct: 505 CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDL--------------------------- 537
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
RL D EV+ +T IF L +L K+ L+ N ++ + EG F
Sbjct: 538 ----------------RLNDNEVSVLE----ATGIFKKLPNLRKINLSNNKIKEVREGAF 577
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLS 201
A+++ L L GNQL+ + R+F+ L+ LKTL L NL+ + + F L+S++ L L
Sbjct: 578 DGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLY 637
Query: 202 NNALSGLPQGVFGKLGSLQELFLDSNNIS------------ELPPQVFSQLFCLERLWLQ 249
+N ++ + G F L SL + L SN + V C + +L+
Sbjct: 638 DNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLK 697
Query: 250 RNAITHLPLSIFASLGNL------------------TFLSLQWNMLRVLPAGLFAHTPCL 291
I + + F GN T + LR LP G+ +
Sbjct: 698 EIPIQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGM---PKDV 754
Query: 292 VGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTA 351
L L N L V A L +L + LS N+I+ L F ++ L L L N L
Sbjct: 755 TELYLEGNHLTAVPRELSA-LRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRC 813
Query: 352 LHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQ 411
+ F L L +L+L N ++++PEG F+ +L +LAL NP CDC L +L W++
Sbjct: 814 IPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 162 bits (411), Expect = 6e-40
Identities = 124/408 (30%), Positives = 185/408 (45%), Gaps = 52/408 (12%)
Query: 22 CPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVV 79
CP C+C Q V C L +P IP +ET+ + N K V
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIP---------------IETKILDLSKNRLKSV 72
Query: 80 FLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEG 139
P+ F P LE+++++ + N+ F+NL +L L L N L+ +P G
Sbjct: 73 ---------NPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLG 123
Query: 140 LFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLK 199
+F L+ L L + N++ L +FQ L +LK+L + N L + F L SL+ L
Sbjct: 124 VFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLT 183
Query: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLS 259
L L+ +P L SL L L NI+ +P F +LF L+ L +
Sbjct: 184 LEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEID---------- 233
Query: 260 IFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLM 319
W +L ++PA + L LS+T+ L TV F HL L L
Sbjct: 234 -------------YWPLLDMMPANSL-YGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLN 279
Query: 320 LSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEG 379
LSYN I+ + AG+F DL L +L++ L + P FQ L L +L++S+N L TL E
Sbjct: 280 LSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEEN 339
Query: 380 IFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGP 427
+F + L L+++ NP CDC L ++ +Q T + Q CAGP
Sbjct: 340 VFSSPRALEVLSINNNPLACDCRLLWILQ--RQPTLQFGGQQPMCAGP 385
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 159 bits (401), Expect = 8e-39
Identities = 139/449 (30%), Positives = 197/449 (43%), Gaps = 65/449 (14%)
Query: 6 WLLWTSLLLLARPAQP-----CPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVE 58
WL SL LL PA P CP C+C VQ V C+ L VP IP
Sbjct: 4 WLCVLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPA--------- 54
Query: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
ETR + N + + P LP LE+L+
Sbjct: 55 ------ETRLLELSRNRIRCL---------NPGDLAALPALEELD--------------- 84
Query: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
L+ N + + G F +L L L L+GNQL+ +P +F L +L L+L++
Sbjct: 85 ---------LSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSE 135
Query: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
N L L + F L SL+ L++ +N L + + F L +L+EL L+ N++ L +
Sbjct: 136 NKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLG 195
Query: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVLPAGLFAHTPCLVGLSLT 297
L L L L+ AI L F L L L + W +L + AG L LS+T
Sbjct: 196 HLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-LTSLSVT 254
Query: 298 HNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
H + V H ++L L LS+N I+ +P G FRDL L +L+L L + P F
Sbjct: 255 HTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAF 314
Query: 358 QNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL 417
L ++ LL+LS N L+TL E F + L L + GNP CDC L W+ Q +
Sbjct: 315 LGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLL----WIVQ-RRKT 369
Query: 418 LNIQ---TYCAGPAYLKGQVVPALNEKQL 443
LN CA PA ++G + L + L
Sbjct: 370 LNFDGRLPACATPAEVRGDALRNLPDSVL 398
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 158 bits (400), Expect = 1e-38
Identities = 118/331 (35%), Positives = 165/331 (49%), Gaps = 13/331 (3%)
Query: 65 ETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLG 124
E F S+ NLT++ PD G + L + G++ ++ F NL+SLG
Sbjct: 93 ELSVFCSSRNLTRL-----------PDGVPG--GTQALWLDGNNLSSVPPAAFQNLSSLG 139
Query: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184
L L L +L L L LHL+ NQL++L F L +L L+ N L++L
Sbjct: 140 FLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRL 199
Query: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
+ LF L SL L L N+L+ LP F LGSL+EL L N ++ L P +FS L L
Sbjct: 200 EDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELR 259
Query: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
L L RNA+ + ++F L L L L N++ + G F L L L+HN++ +
Sbjct: 260 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 319
Query: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
E TF L LR L LS+NAI L F+DL L +L LG N + L F+ L +LE
Sbjct: 320 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 379
Query: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
+L+L NQL + G F N+ + L GN
Sbjct: 380 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 410
Score = 157 bits (396), Expect = 3e-38
Identities = 159/547 (29%), Positives = 211/547 (38%), Gaps = 134/547 (24%)
Query: 22 CPMGCDCFVQE------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
CP C C + VFCS L +P +P T+ + + +++ AF NL
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF---QNL 135
Query: 76 TKVVFLNTQ---LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
+ + FLN Q L P A GL L L + + +L+ F++ +L L L+ N
Sbjct: 136 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 195
Query: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
L L +GLF+ L +L L+L N L LP F+ L L+ L LA N LA L LF L
Sbjct: 196 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 255
Query: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPP------------------ 234
L+ L LS NAL + VF +L LQ+L+LD N I+ + P
Sbjct: 256 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 315
Query: 235 ------QVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHT 288
F L L L L NAI L F L L L L N +R L F
Sbjct: 316 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 375
Query: 289 PCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL------------ 336
L L+L HNQL+ V G F L+N+ + LS N + +LP +FR L
Sbjct: 376 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 435
Query: 337 ------------------------------------EELVKLYLGSNNLTALHPALFQNL 360
EL++L L SN LT L LFQ L
Sbjct: 436 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 495
Query: 361 SKLELLSLSKNQLTTLPEGI---------FDTNYN------------------------- 386
KLE L LS+N+L LP D ++N
Sbjct: 496 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 555
Query: 387 ----------LFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTYCAG-----PAYL 430
L L L GNPW C C L L ++ Q + +Q C G PAY
Sbjct: 556 LRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 615
Query: 431 KGQVVPA 437
+ A
Sbjct: 616 YNNITCA 622
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 158 bits (400), Expect = 1e-38
Identities = 118/331 (35%), Positives = 165/331 (49%), Gaps = 13/331 (3%)
Query: 65 ETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLG 124
E F S+ NLT++ PD G + L + G++ ++ F NL+SLG
Sbjct: 55 ELSVFCSSRNLTRL-----------PDGVPG--GTQALWLDGNNLSSVPPAAFQNLSSLG 101
Query: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184
L L L +L L L LHL+ NQL++L F L +L L+ N L++L
Sbjct: 102 FLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRL 161
Query: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
+ LF L SL L L N+L+ LP F LGSL+EL L N ++ L P +FS L L
Sbjct: 162 EDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELR 221
Query: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
L L RNA+ + ++F L L L L N++ + G F L L L+HN++ +
Sbjct: 222 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 281
Query: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
E TF L LR L LS+NAI L F+DL L +L LG N + L F+ L +LE
Sbjct: 282 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
Query: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
+L+L NQL + G F N+ + L GN
Sbjct: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
Score = 157 bits (396), Expect = 3e-38
Identities = 159/547 (29%), Positives = 211/547 (38%), Gaps = 134/547 (24%)
Query: 22 CPMGCDCFVQE------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
CP C C + VFCS L +P +P T+ + + +++ AF NL
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF---QNL 97
Query: 76 TKVVFLNTQ---LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
+ + FLN Q L P A GL L L + + +L+ F++ +L L L+ N
Sbjct: 98 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
Query: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
L L +GLF+ L +L L+L N L LP F+ L L+ L LA N LA L LF L
Sbjct: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
Query: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPP------------------ 234
L+ L LS NAL + VF +L LQ+L+LD N I+ + P
Sbjct: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
Query: 235 ------QVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHT 288
F L L L L NAI L F L L L L N +R L F
Sbjct: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
Query: 289 PCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL------------ 336
L L+L HNQL+ V G F L+N+ + LS N + +LP +FR L
Sbjct: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
Query: 337 ------------------------------------EELVKLYLGSNNLTALHPALFQNL 360
EL++L L SN LT L LFQ L
Sbjct: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457
Query: 361 SKLELLSLSKNQLTTLPEGI---------FDTNYN------------------------- 386
KLE L LS+N+L LP D ++N
Sbjct: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
Query: 387 ----------LFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTYCAG-----PAYL 430
L L L GNPW C C L L ++ Q + +Q C G PAY
Sbjct: 518 LRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 577
Query: 431 KGQVVPA 437
+ A
Sbjct: 578 YNNITCA 584
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 157 bits (398), Expect = 2e-38
Identities = 127/430 (29%), Positives = 198/430 (46%), Gaps = 53/430 (12%)
Query: 12 LLLLARPAQPCPMGCD-CFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFG 70
LLLL + C C C +++ C + L+++P + P T +F+ + T ++
Sbjct: 22 LLLLHKEILGCSSVCQLCTGRQINCRNLGLSSIPKNFPEST---VFL---YLTGNNISYI 75
Query: 71 SNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNF 130
+ LT GL L L + S+ L + F L L L LN
Sbjct: 76 NESELT------------------GLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNN 117
Query: 131 NMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFH 190
N ++ L G+F+ L L +L+LQ NQ+ +PR +F L ++ LNL +N L L F
Sbjct: 118 NFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFV 177
Query: 191 PLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQR 250
+ +L+ L LSNN + + + F L +L L+L SNN++++P F L L RL L
Sbjct: 178 GMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH 237
Query: 251 NAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFA 310
N I + F L NL +L L+ + +R + F+ L L L+HN LE + TF+
Sbjct: 238 NPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFS 297
Query: 311 HLSNLRSLMLSYNAITHLPAGIFRDLEELVK-LYLGSNNLTALHPALFQNLSKLELLSLS 369
L NL L L N I + F ++ +K L L NNLTALHP + + LS
Sbjct: 298 LLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLS-------- 349
Query: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAY 429
+L +L + NPW+C+C L L +WL + + YC P
Sbjct: 350 ----------------SLIHLQANSNPWECNCKLLGLRDWL---ASSAITLNIYCQNPPS 390
Query: 430 LKGQVVPALN 439
++G+ + +N
Sbjct: 391 MRGRALRYIN 400
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 157 bits (397), Expect = 2e-38
Identities = 118/430 (27%), Positives = 200/430 (46%), Gaps = 26/430 (6%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V C + L +P ++P I ++ AF L ++
Sbjct: 282 CPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLS 341
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
N Q+ + PDAF GL L L + G+ +L +F L +L L LN N + + F
Sbjct: 342 NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAF 401
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL------LAQLPEEL-FHPLTS 194
Q L L L L N++Q+L + F L ++TL+LAQN L L + L +P+ +
Sbjct: 402 QDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIET 461
Query: 195 -----LQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQ 249
+L+N + + F + + ++ F+ +L + S + C + +
Sbjct: 462 SGARCASPRRLANKRIGQIKSKKF-RCSAKEQYFIPGTEDYQLNSECNSDVVCPHKCRCE 520
Query: 250 RNAI-------THLPLSIFASLGNLTFLSLQWNMLRVLPA-GLFAHTPCLVGLSLTHNQL 301
N + T +P I S L L N + +L A G+F L ++L++N++
Sbjct: 521 ANVVECSSLKLTKIPERIPQSTAELR---LNNNEISILEATGMFKKLTHLKKINLSNNKV 577
Query: 302 ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLS 361
+ +G F +++ L L+ N + + +G+FR L+ L L L +N ++ +H F L
Sbjct: 578 SEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLR 637
Query: 362 KLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQ 421
+ LLSL NQ+TT+ G FDT +L L L NP+ C+C LA+L WL++ +++
Sbjct: 638 NVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK--RKIVTGN 695
Query: 422 TYCAGPAYLK 431
C P +L+
Sbjct: 696 PRCQNPDFLR 705
Score = 139 bits (349), Expect = 9e-33
Identities = 133/514 (25%), Positives = 205/514 (39%), Gaps = 113/514 (21%)
Query: 3 PGAWLL-WTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSF 61
P WLL W + L A CP C C V C L +P +IP T+ +
Sbjct: 16 PELWLLLWAAAWRLG--ASACPALCTCTGTTVDCHGTGLQAIPKNIPRNTERLEL----- 68
Query: 62 TTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLT 121
+ N+T++ + F GL +L L++ + + F ++
Sbjct: 69 ---------NGNNITRI----------HKNDFAGLKQLRVLQLMENQIGAVERGAFDDMK 109
Query: 122 SLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
L +L LN N L LPE LFQ+ AL L L N +QA+PR+ F+ T LK L L +N +
Sbjct: 110 ELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQI 169
Query: 182 AQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLF 241
+ + E F L L+ L L+NN ++ +P F + L+ L SN+ LF
Sbjct: 170 SCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNH-----------LF 218
Query: 242 C-LERLWLQRNAITHLPLSIF------ASLGNLTFLSLQWNM------------------ 276
C WL + + +F ASL L +Q +
Sbjct: 219 CDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLS 278
Query: 277 ---------------------LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNL 315
L +PA L + + L N ++++ G F+ L
Sbjct: 279 SGSCPAMCTCSNGIVDCRGKGLTAIPANL---PETMTEIRLELNGIKSIPPGAFSPYRKL 335
Query: 316 RSLMLSY------------------------NAITHLPAGIFRDLEELVKLYLGSNNLTA 351
R + LS N IT LP G+F L L L L +N +
Sbjct: 336 RRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINC 395
Query: 352 LHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQ 411
+ P FQ+L L LLSL N++ +L +G F + + L L NP+ CDC+L +L ++L+
Sbjct: 396 IRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLR 455
Query: 412 QYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
T+ + CA P L + + + K+ C
Sbjct: 456 --TNPIETSGARCASPRRLANKRIGQIKSKKFRC 487
Score = 125 bits (314), Expect = 1e-28
Identities = 123/462 (26%), Positives = 188/462 (40%), Gaps = 98/462 (21%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V CS +L +P IP T + + LE
Sbjct: 513 CPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILE---------------- 556
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
+T +F LT L K+ L+ N + + +G F
Sbjct: 557 -------------------------------ATGMFKKLTHLKKINLSNNKVSEIEDGAF 585
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLS 201
+ A++ LHL NQL+++ +F+ L L+TL L N ++ + + F L +++ L L
Sbjct: 586 EGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLY 645
Query: 202 NNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAIT------- 254
+N ++ + G F L SL L L +N P QL L WL++ I
Sbjct: 646 DNQITTVSPGAFDTLQSLSTLNLLAN-----PFNCNCQLAWLGG-WLRKRKIVTGNPRCQ 699
Query: 255 ------HLPLSIFA-----------SLGNL-------------TFLSLQWNMLRVLPAGL 284
+PL A G L T + LR LP G+
Sbjct: 700 NPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGI 759
Query: 285 FAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYL 344
+ + L L NQ T+ G + L+ + LS N I+ L F ++ +L L L
Sbjct: 760 PKN---VTELYLDGNQF-TLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLIL 815
Query: 345 GSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLA 404
N L + P FQ L L LLSL N ++TL EGIF +L +LA+ NP CDCHL
Sbjct: 816 SYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLR 875
Query: 405 YLFNWLQQ-YTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
+L +W++ Y + + CAGP ++G+++ K+ C
Sbjct: 876 WLSSWVKTGYKEPGI---ARCAGPQDMEGKLLLTTPAKKFEC 914
Score = 60.8 bits (146), Expect = 3e-09
Identities = 41/164 (25%), Positives = 66/164 (40%), Gaps = 25/164 (15%)
Query: 18 PAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTK 77
P CP C C V CS++ L +P IP + FT +
Sbjct: 730 PRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV------------- 776
Query: 78 VVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALP 137
P L+ ++++ + +LS + F+N++ L L L++N L+ +P
Sbjct: 777 ------------PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIP 824
Query: 138 EGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLL 181
FQ L +L L L GN + L +F +T L L + N L
Sbjct: 825 PLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 156 bits (395), Expect = 4e-38
Identities = 144/513 (28%), Positives = 216/513 (42%), Gaps = 43/513 (8%)
Query: 3 PGAWLLWTSLLLL------ARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIF 56
P LLW LL L A P PC C C + C LA +P D+P +T+++
Sbjct: 16 PCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRSLNL 75
Query: 57 VETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNI 116
+ ++ F PNL +V N +L P + L + + ++ +
Sbjct: 76 SYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVEGSQ 134
Query: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTH-LKTLN 175
SL L L+ N + + F H ++ L+L GN++ L F L+ L TL
Sbjct: 135 LKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLTLR 194
Query: 176 LAQNLLAQLPEELF-----------------------HPLTSLQTLKLSNNALSGLPQGV 212
L++N + QLP F L SL+ LKL N +S L G
Sbjct: 195 LSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGA 254
Query: 213 FGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSL 272
F L + L L+ N++ E+ L L +L L N+I + ++ L L L
Sbjct: 255 FWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVL 314
Query: 273 QWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL---P 329
+N L L A L L L+HN + +AEG F L +LR L L +N I+
Sbjct: 315 SFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDT 374
Query: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
+G F L+ L KL L N + ++ F L LE L+L N + ++ F NL
Sbjct: 375 SGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKE 434
Query: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLN--IQTYCAGPAYLKGQVVPALNEKQLVCPV 447
L + + + CDC L +L WL R+L + CA P LKGQ + ++ + VC
Sbjct: 435 LHISSDSFLCDCQLKWLPPWL---IGRMLQAFVTATCAHPESLKGQSIFSVPPESFVCD- 490
Query: 448 TRDHLGFQ-VTWPDESKAGGSWDLAVQERAARS 479
D L Q +T P+ + A D+ AA S
Sbjct: 491 --DFLKPQIITQPETTMAMVGKDIRFTCSAASS 521
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 155 bits (391), Expect = 1e-37
Identities = 130/467 (27%), Positives = 216/467 (46%), Gaps = 35/467 (7%)
Query: 10 TSLLLL-ARPAQPCPMGCDCFVQEVFCSDEELATVPLD-----IPPYTKNIIF------- 56
T+LLLL A A CP C C + + CS +L +PP T + F
Sbjct: 30 TALLLLPAAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSN 89
Query: 57 ------------VETSFTTLETRAFGSNP--NLTKVVFLNTQLCQFRPDAFGGLPRLEDL 102
V+ ++ L + P N+T + ++ + + A P LE L
Sbjct: 90 WNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESL 149
Query: 103 EVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA-LESLHLQGNQLQALP 161
+++ + + T+ F + L L L+ N + L G F +L++ L + L N++ +P
Sbjct: 150 DLSSNIISEIKTSSFPRM-QLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIP 208
Query: 162 RRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221
++F+ L HL+ L L +N + + F L SL++LK+ N +S L G F L +++E
Sbjct: 209 PKIFK-LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEE 267
Query: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP 281
L L+ NN++ + L L++L++ +NAI + + L+ L L +N L L
Sbjct: 268 LELEHNNLTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLD 327
Query: 282 AGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL---PAGIFRDLEE 338
F L L+L N++ +A+G F LSNL++L L N I+ + F L
Sbjct: 328 ESAFVGLSLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTS 387
Query: 339 LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
L KL L N + ++ F L LE L L+ N + ++ E F + L L L+ +
Sbjct: 388 LTKLILQGNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLL 446
Query: 399 CDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
CDCHL +L WL + ++ CA P +L GQ + ++ K VC
Sbjct: 447 CDCHLKWLLQWLVD-NNFQHSVNVSCAHPEWLAGQSILNVDLKDFVC 492
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 153 bits (387), Expect = 3e-37
Identities = 127/437 (29%), Positives = 195/437 (44%), Gaps = 66/437 (15%)
Query: 9 WTSLLLL------ARPAQPCPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVETS 60
W +LLL + A CP C+C Q+ V C + VP IP
Sbjct: 23 WQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPT----------- 71
Query: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
ETR N K + D F P LE+LE
Sbjct: 72 ----ETRLLDLGKNRIKTL---------NQDEFASFPHLEELE----------------- 101
Query: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
LN N++ A+ G F +L L +L L+ N+L+ +P +F L++L L++++N
Sbjct: 102 -------LNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENK 154
Query: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
+ L + +F L +L++L++ +N L + F L SL++L L+ N++ +P + S L
Sbjct: 155 IVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214
Query: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVL-PAGLFAHTPCLVGLSLTH 298
L L L+ I + F L L L + W L + P L+ L LS+TH
Sbjct: 215 HGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLN--LTSLSITH 272
Query: 299 NQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358
L V HL LR L LSYN I+ + + +L L ++ L L + P F+
Sbjct: 273 CNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFR 332
Query: 359 NLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLF--NWLQQYTDR 416
L+ L +L++S NQLTTL E +F + NL L L NP CDC L ++F W + +
Sbjct: 333 GLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ 392
Query: 417 LLNIQTYCAGPAYLKGQ 433
Q CA P +++G+
Sbjct: 393 ----QPTCATPEFVQGK 405
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 149 bits (375), Expect = 8e-36
Identities = 131/436 (30%), Positives = 187/436 (42%), Gaps = 58/436 (13%)
Query: 5 AWLLWTSLLLL----ARPAQPCPMGCDCFVQE--VFCSDEELATVPLDIPPYTKNIIFVE 58
AW W LL L CP CDC Q V C +L VP +P
Sbjct: 10 AWPPWPPLLFLLLLPGGSGGSCPAVCDCTSQPQAVLCGHRQLEAVPGGLP---------- 59
Query: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
L+T+L L+++G+ L + S
Sbjct: 60 ----------------------LDTEL----------------LDLSGNRLWGLQQGMLS 81
Query: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
L+ L +L L++N L L G F L +L +L LQGN+L+ + +F L+ L L+L
Sbjct: 82 RLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRL 141
Query: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
N + + F L SLQ L++ +N L + G F L L L L+ N+S +P +
Sbjct: 142 NQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALA 201
Query: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQ-WNMLRVLPAGLFAHTPCLVGLSLT 297
+L L L L+ I LP LG L L + W L L G L L++T
Sbjct: 202 RLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGLN-LSSLAIT 260
Query: 298 HNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALF 357
L +V HLS LR L LS N I+ +PA L L +L L LT++ F
Sbjct: 261 RCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAF 320
Query: 358 QNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL 417
L+ LL ++ N L TL E F + L L L GNP CDC L +L L+++ D
Sbjct: 321 HGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRLLWLLR-LRRHLDFG 379
Query: 418 LNIQTYCAGPAYLKGQ 433
++ CAGP +++G+
Sbjct: 380 MS-PPACAGPHHVQGK 394
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 145 bits (365), Expect = 1e-34
Identities = 124/453 (27%), Positives = 206/453 (45%), Gaps = 31/453 (6%)
Query: 20 QPCPMGCDCFVQEVFCSDEELATVPLDIPPYT-------KNIIFVETSFTT--------- 63
+PCP C C + CS + LA +P +P + + F++ S +
Sbjct: 45 RPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVK 104
Query: 64 LETRAFGSNPNL-------TKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNI 116
L + PNL T + ++ + P+ LE L+++ ++ L T
Sbjct: 105 LNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-A 163
Query: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLA-ALESLHLQGNQLQALPRRLFQPLTHLKTLN 175
F L L L LN N + ++ G F +LA L L L N++ A+P ++F+ L L+ L
Sbjct: 164 FPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLE 221
Query: 176 LAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQ 235
L +N + + F L +L++LK+ N ++ L G F L +++ L LD NN++E+
Sbjct: 222 LNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKG 281
Query: 236 VFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLS 295
L L+ L L +NAI + + L+ L L +N L L F L L
Sbjct: 282 WLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLH 341
Query: 296 LTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL---PAGIFRDLEELVKLYLGSNNLTAL 352
+ +N++ +A+ F LS+L++L L N I+ G F L++L +L L N + ++
Sbjct: 342 IGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSI 401
Query: 353 HPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQ 412
F L LE L LS N + +L F L L L+ + CDC L +L W+ +
Sbjct: 402 TKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAE 461
Query: 413 YTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
+ + CA P LKG+ + A++ VC
Sbjct: 462 NNFQSF-VNASCAHPQLLKGRSIFAVSPDGFVC 493
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 142 bits (357), Expect = 1e-33
Identities = 105/299 (35%), Positives = 135/299 (45%), Gaps = 5/299 (1%)
Query: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207
+ L LQGN L+ +P FQ + HL L+L + + E F L L L L++N L
Sbjct: 65 QRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 124
Query: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
LPQ LGSL+ L L+ N + EL P F L L L L NA+ +LP F L +
Sbjct: 125 LPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRV 184
Query: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
+L L N L VL A P L LSL HN+L+ + + L L L +N +T+
Sbjct: 185 RWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTY 244
Query: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
L L +L L L AL P F + +L L L NQL TLP L
Sbjct: 245 AGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQL 302
Query: 388 FNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVCP 446
L L GNP C C L WL + R C GP L+G+ + AL L CP
Sbjct: 303 RRLRLQGNPLWCGCQARPLLEWLARARVR---SDGACQGPRRLRGEALDALRPWDLRCP 358
Score = 111 bits (277), Expect = 2e-24
Identities = 100/299 (33%), Positives = 128/299 (42%), Gaps = 30/299 (10%)
Query: 12 LLLLA----RPAQPCPMGCDC--FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE 65
LLLLA AQ CP C C + V C + L VP IP T+ + +
Sbjct: 19 LLLLAPARQAAAQRCPQACICDNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIP 78
Query: 66 TRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGK 125
AF P+LT + + ++ AF GL RL + NL S
Sbjct: 79 AAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRL----------------LLLNLAS--- 119
Query: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
N L LP+ L +L L L+GN L+ L F L L TLNLA N L LP
Sbjct: 120 -----NHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNALVYLP 174
Query: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
F L ++ L+LS+NALS L L +L+ L L N + LP V SQ L R
Sbjct: 175 AMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLAR 234
Query: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
L L N +T+ +L L L L L+ L FAH P L L L NQL+T+
Sbjct: 235 LELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTL 293
Score = 102 bits (255), Expect = 7e-22
Identities = 97/322 (30%), Positives = 122/322 (37%), Gaps = 29/322 (9%)
Query: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
L L N ++P F L L SLHLQ + L L L L L+ N LA L
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
Query: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
L L L N +P L SL L L N + L P + L
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRW 549
Query: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
++L N IT + L L L L N LR +P G P L+ L L+ N L +
Sbjct: 550 VYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALR 609
Query: 306 EGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSK-LE 364
+G F P G L L+L S+ L + P F L L+
Sbjct: 610 DGAFQ------------------PVG-----RSLQHLFLNSSGLEQICPGAFSGLGPGLQ 646
Query: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYC 424
L L KNQL LP + L +L+ NP+ CDC L L WL T L + C
Sbjct: 647 SLHLQKNQLRALPALPSLSQLELIDLS--SNPFHCDCQLLPLHRWL---TGLNLRVGATC 701
Query: 425 AGPAYLKGQVVPALNEKQLVCP 446
A P +GQ V A CP
Sbjct: 702 ATPPNARGQRVKAAAAVFEDCP 723
>gi|7019381 fibronectin leucine rich transmembrane protein 2 [Homo
sapiens]
Length = 660
Score = 141 bits (356), Expect = 1e-33
Identities = 119/430 (27%), Positives = 175/430 (40%), Gaps = 105/430 (24%)
Query: 22 CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFL 81
CP C C V+C++ L +VPL IP +T +
Sbjct: 36 CPSVCRCDRNFVYCNERSLTSVPLGIPE------------------------GVTVLYLH 71
Query: 82 NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLF 141
N Q+ G P N+ S+ + L N L+ P L
Sbjct: 72 NNQINN------AGFPAE-----------------LHNVQSVHTVYLYGNQLDEFPMNLP 108
Query: 142 QHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEE--LFHPLTSLQTLK 199
+++ L HLQ N +Q + R L L+ L+L N ++ + E F SL+ L
Sbjct: 109 KNVRVL---HLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLF 165
Query: 200 LSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLS 259
LS N LS +P G+ LQEL +D N I+ + F L LERL + N +T+
Sbjct: 166 LSKNHLSSVPVGL---PVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTN---- 218
Query: 260 IFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLM 319
+ +AEGTF+HL+ L+
Sbjct: 219 ------------------------------------------KGIAEGTFSHLTKLKEFS 236
Query: 320 LSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEG 379
+ N+++H P + L++LYL N + + F NL KLE L +S NQL L +G
Sbjct: 237 IVRNSLSHPPPDL--PGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQG 294
Query: 380 IFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTY-CAGPAYLKGQVVPAL 438
+FD NL L NPW CDC + ++ WL +Y LN++ + C GP ++G V L
Sbjct: 295 VFDNLSNLKQLTARNNPWFCDCSIKWVTEWL-KYIPSSLNVRGFMCQGPEQVRGMAVREL 353
Query: 439 NEKQLVCPVT 448
N L CP T
Sbjct: 354 NMNLLSCPTT 363
>gi|156139147 leucine rich repeat transmembrane neuronal 4 isoform b
[Homo sapiens]
Length = 518
Score = 140 bits (352), Expect = 4e-33
Identities = 91/298 (30%), Positives = 143/298 (47%), Gaps = 1/298 (0%)
Query: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207
+ L L+ N +Q L F L L L L N ++ + E+ F + L+ L LS+N ++
Sbjct: 64 QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITY 123
Query: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
L F + +L+ L L N + L + F L L L L+ N++ +P+ +F NL
Sbjct: 124 LHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNL 183
Query: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
FL L +N LR L FA L L L HNQ + F L NLRS+ L +N I
Sbjct: 184 DFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 243
Query: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
+ G+ L L L N++ + P F+ L L+ L+L N+LT + + + +L
Sbjct: 244 ISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303
Query: 388 FNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
++ L GN W+C + LF WL+ + + CAGP +++G+ V E +C
Sbjct: 304 ISITLSGNMWECSRSICPLFYWLKNFKGNKESTM-ICAGPKHIQGEKVSDAVETYNIC 360
Score = 108 bits (270), Expect = 1e-23
Identities = 90/318 (28%), Positives = 145/318 (45%), Gaps = 25/318 (7%)
Query: 7 LLWTSLLLLARPAQ-PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE 65
LL T LL++ AQ CP C C + V+C A +P +I ++ + S L+
Sbjct: 18 LLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK 77
Query: 66 TRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGK 125
+ F L + + + DAF G+ RL++L ++ + L F + +L
Sbjct: 78 SNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRN 137
Query: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
L L++N L+ L F+ L L LHL+ N L+ +P R+FQ +L L+L N L
Sbjct: 138 LDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLR--- 194
Query: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
LS NA +GL + L+EL L+ N S++ F +LF L
Sbjct: 195 -------------SLSRNAFAGLLK--------LKELHLEHNQFSKINFAHFPRLFNLRS 233
Query: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
++LQ N I + + + +L L L N ++ + G F P L L+L N+L ++
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNIS 293
Query: 306 EGTFAHLSNLRSLMLSYN 323
+ T +L S+ LS N
Sbjct: 294 QETVNAWISLISITLSGN 311
Score = 74.3 bits (181), Expect = 3e-13
Identities = 73/243 (30%), Positives = 108/243 (44%), Gaps = 18/243 (7%)
Query: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSN------------NALSGLPQGV 212
F +T LK +++ +L LP L LT Q N +A + +P+ +
Sbjct: 3 FHLITQLKGMSV---VLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENI 59
Query: 213 FGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSL 272
G GS Q L L N+I +L F+ L L L+L N I+ + F + L L L
Sbjct: 60 SG--GS-QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELIL 116
Query: 273 QWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGI 332
N + L F P L L L++N+L+T+ F L L L L N++ +P +
Sbjct: 117 SSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRV 176
Query: 333 FRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL 392
F+D L L LG N L +L F L KL+ L L NQ + + F +NL ++ L
Sbjct: 177 FQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYL 236
Query: 393 HGN 395
N
Sbjct: 237 QWN 239
>gi|197927168 leucine rich repeat transmembrane neuronal 4 isoform a
[Homo sapiens]
Length = 590
Score = 140 bits (352), Expect = 4e-33
Identities = 91/298 (30%), Positives = 143/298 (47%), Gaps = 1/298 (0%)
Query: 148 ESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSG 207
+ L L+ N +Q L F L L L L N ++ + E+ F + L+ L LS+N ++
Sbjct: 64 QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITY 123
Query: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNL 267
L F + +L+ L L N + L + F L L L L+ N++ +P+ +F NL
Sbjct: 124 LHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNL 183
Query: 268 TFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
FL L +N LR L FA L L L HNQ + F L NLRS+ L +N I
Sbjct: 184 DFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYLQWNRIRS 243
Query: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNL 387
+ G+ L L L N++ + P F+ L L+ L+L N+LT + + + +L
Sbjct: 244 ISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNISQETVNAWISL 303
Query: 388 FNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQVVPALNEKQLVC 445
++ L GN W+C + LF WL+ + + CAGP +++G+ V E +C
Sbjct: 304 ISITLSGNMWECSRSICPLFYWLKNFKGNKESTM-ICAGPKHIQGEKVSDAVETYNIC 360
Score = 108 bits (270), Expect = 1e-23
Identities = 90/318 (28%), Positives = 145/318 (45%), Gaps = 25/318 (7%)
Query: 7 LLWTSLLLLARPAQ-PCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLE 65
LL T LL++ AQ CP C C + V+C A +P +I ++ + S L+
Sbjct: 18 LLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENISGGSQGLSLRFNSIQKLK 77
Query: 66 TRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGK 125
+ F L + + + DAF G+ RL++L ++ + L F + +L
Sbjct: 78 SNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELILSSNKITYLHNKTFHPVPNLRN 137
Query: 126 LTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLP 185
L L++N L+ L F+ L L LHL+ N L+ +P R+FQ +L L+L N L
Sbjct: 138 LDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRVFQDCRNLDFLDLGYNRLR--- 194
Query: 186 EELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLER 245
LS NA +GL + L+EL L+ N S++ F +LF L
Sbjct: 195 -------------SLSRNAFAGLLK--------LKELHLEHNQFSKINFAHFPRLFNLRS 233
Query: 246 LWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVA 305
++LQ N I + + + +L L L N ++ + G F P L L+L N+L ++
Sbjct: 234 IYLQWNRIRSISQGLTWTWSSLHNLDLSGNDIQGIEPGTFKCLPNLQKLNLDSNKLTNIS 293
Query: 306 EGTFAHLSNLRSLMLSYN 323
+ T +L S+ LS N
Sbjct: 294 QETVNAWISLISITLSGN 311
Score = 74.3 bits (181), Expect = 3e-13
Identities = 73/243 (30%), Positives = 108/243 (44%), Gaps = 18/243 (7%)
Query: 165 FQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSN------------NALSGLPQGV 212
F +T LK +++ +L LP L LT Q N +A + +P+ +
Sbjct: 3 FHLITQLKGMSV---VLVLLPTLLLVMLTGAQRACPKNCRCDGKIVYCESHAFADIPENI 59
Query: 213 FGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSL 272
G GS Q L L N+I +L F+ L L L+L N I+ + F + L L L
Sbjct: 60 SG--GS-QGLSLRFNSIQKLKSNQFAGLNQLIWLYLDHNYISSVDEDAFQGIRRLKELIL 116
Query: 273 QWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGI 332
N + L F P L L L++N+L+T+ F L L L L N++ +P +
Sbjct: 117 SSNKITYLHNKTFHPVPNLRNLDLSYNKLQTLQSEQFKGLRKLIILHLRSNSLKTVPIRV 176
Query: 333 FRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLAL 392
F+D L L LG N L +L F L KL+ L L NQ + + F +NL ++ L
Sbjct: 177 FQDCRNLDFLDLGYNRLRSLSRNAFAGLLKLKELHLEHNQFSKINFAHFPRLFNLRSIYL 236
Query: 393 HGN 395
N
Sbjct: 237 QWN 239
>gi|7662102 leucine rich repeat transmembrane neuronal 2 [Homo
sapiens]
Length = 516
Score = 138 bits (348), Expect = 1e-32
Identities = 94/295 (31%), Positives = 151/295 (51%), Gaps = 2/295 (0%)
Query: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
L L+ N + L R F + L L+L N ++ + E+ F L L+ L LS+N + LP
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
F +L +LQ L L N +S L P++F L L+ L L+ N++ +P+ +F +L F
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
Query: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
L L N LR L FA L L L HNQL + F LS+L +L L +N I++L
Sbjct: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
Query: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
G+ L KL L N + A+ +F+ + L++L + N+L +L I ++ +L
Sbjct: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
Query: 390 LALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKGQ-VVPALNEKQL 443
+ L GN W+C + L +WL + R + C P + +G+ ++ A++ QL
Sbjct: 306 VGLSGNLWECSARICALASWLGSFQGRWEH-SILCHSPDHTQGEDILDAVHGFQL 359
Score = 121 bits (303), Expect = 2e-27
Identities = 92/305 (30%), Positives = 139/305 (45%)
Query: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETS 60
ML + + L +L CP C C +C + +VP + +
Sbjct: 13 MLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSVPNATDKGSLGLSLRHNH 72
Query: 61 FTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNL 120
T LE F S LT + + Q+ + DAF GL +L++L ++ + L F+ L
Sbjct: 73 ITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQL 132
Query: 121 TSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNL 180
+L L L+FN L +L LF L L++LHL+ N L+ +P RLF L+ L+L+ N
Sbjct: 133 INLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNR 192
Query: 181 LAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQL 240
L L F L L+ L L +N L+ + F +L SL LFL N IS L +
Sbjct: 193 LRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTW 252
Query: 241 FCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQ 300
LE+L L N I + L++F ++ NL L + N L L + + L + L+ N
Sbjct: 253 GTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTTVGLSGNL 312
Query: 301 LETVA 305
E A
Sbjct: 313 WECSA 317
Score = 114 bits (285), Expect = 2e-25
Identities = 77/246 (31%), Positives = 121/246 (49%)
Query: 102 LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALP 161
L + + L + F++ + L L L+ N + + E FQ L L+ L L N++ LP
Sbjct: 66 LSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP 125
Query: 162 RRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQE 221
F L +L+ L+L+ N L+ L ELF+ L LQTL L +N+L +P +F SL+
Sbjct: 126 NTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEF 185
Query: 222 LFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLP 281
L L +N + L F+ L L L L+ N +T + + F L +L L LQWN + L
Sbjct: 186 LDLSTNRLRSLARNGFAGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQWNKISNLT 245
Query: 282 AGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVK 341
G+ L L LT N+++ + F + NL+ L++ N + L + I L L
Sbjct: 246 CGMEWTWGTLEKLDLTGNEIKAIDLTVFETMPNLKILLMDNNKLNSLDSKILNSLRSLTT 305
Query: 342 LYLGSN 347
+ L N
Sbjct: 306 VGLSGN 311
Score = 62.0 bits (149), Expect = 1e-09
Identities = 42/114 (36%), Positives = 52/114 (45%), Gaps = 24/114 (21%)
Query: 292 VGLSLT------------------------HNQLETVAEGTFAHLSNLRSLMLSYNAITH 327
+GLSL HNQ+ TV E F L L+ L+LS N I +
Sbjct: 64 LGLSLRHNHITELERDQFASFSQLTWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFY 123
Query: 328 LPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIF 381
LP F L L L L N L++LHP LF L KL+ L L N L T+P +F
Sbjct: 124 LPNTTFTQLINLQNLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLF 177
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 137 bits (345), Expect = 3e-32
Identities = 129/454 (28%), Positives = 179/454 (39%), Gaps = 66/454 (14%)
Query: 3 PGAWLLWTSLLLLAR-----PAQP------CPMGCDCFVQEVF----CSDEELATVPLDI 47
PG LW L A QP CP C C + CS+ L+ VP D+
Sbjct: 5 PGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDL 64
Query: 48 PPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGS 107
P T + + T L+ F L ++ L AF GL L+ L + +
Sbjct: 65 DPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNN 124
Query: 108 SFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQP 167
+ L SL L L+ N++ +PE F+ L++L L L N L +P R
Sbjct: 125 QLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNN 184
Query: 168 LTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFG------------- 214
L L+ + LA N ++ +P+ F LTSL L L NN + L F
Sbjct: 185 LPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYN 244
Query: 215 ----------KLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
LG LQEL +NNI +P + F L+ + N I + S F L
Sbjct: 245 KLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
Query: 265 GNLTFLSLQWNM-----------------------LRVLPAGLFAHTPCLVGLSLTHNQL 301
L LSL M +R+LP+G+ P L L L+HNQ+
Sbjct: 305 PKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQI 364
Query: 302 ETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLS 361
E + + L + L +N I + A F L L L L N + ++HP F L
Sbjct: 365 EELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLH 422
Query: 362 KLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
L L L+ NQLTTLP L +L L GN
Sbjct: 423 SLVKLDLTDNQLTTLPLAGLG---GLMHLKLKGN 453
Score = 111 bits (278), Expect = 1e-24
Identities = 79/249 (31%), Positives = 115/249 (46%), Gaps = 25/249 (10%)
Query: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
L L N L L LF L L+ L L+ N L+ +P + F L SL+ L L NN L G+P
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
+L SLQ L LD+N IS +P + F L L LWL NA+T +P+ +L L
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
Query: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
++L N + +P F + LV L L +N+++ + +F L NL +L L+YN + P
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
I + L +L+ L N + +PE F N L
Sbjct: 251 VAI-------------------------RTLGRLQELGFHNNNIKAIPEKAFMGNPLLQT 285
Query: 390 LALHGNPWQ 398
+ + NP Q
Sbjct: 286 IHFYDNPIQ 294
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 135 bits (339), Expect = 1e-31
Identities = 108/376 (28%), Positives = 180/376 (47%), Gaps = 8/376 (2%)
Query: 74 NLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNML 133
N+T + ++ + P+ LE L+++ ++ L T F L L L LN N +
Sbjct: 62 NITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRV 119
Query: 134 EALPEGLFQHLA-ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
++ G F +LA L L L N++ A+P ++F+ L L+ L L +N + + F L
Sbjct: 120 TSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGL 178
Query: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
+L++LK+ N ++ L G F L +++ L LD NN++E+ L L+ L L +NA
Sbjct: 179 GALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNA 238
Query: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
I + + L+ L L +N L L F L L + +N++ +A+ F L
Sbjct: 239 INRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGL 298
Query: 313 SNLRSLMLSYNAITHL---PAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369
S+L++L L N I+ G F L++L +L L N + ++ F L LE L LS
Sbjct: 299 SSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLS 358
Query: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQTYCAGPAY 429
N + +L F L L L+ + CDC L +L W+ + + + CA P
Sbjct: 359 DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSF-VNASCAHPQL 417
Query: 430 LKGQVVPALNEKQLVC 445
LKG+ + A++ VC
Sbjct: 418 LKGRSIFAVSPDGFVC 433
Score = 103 bits (257), Expect = 4e-22
Identities = 95/297 (31%), Positives = 149/297 (50%), Gaps = 9/297 (3%)
Query: 101 DLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQL-QA 159
DL SF+ S+ S+L SL ++ LN N LE +P L A + L L GN++ +
Sbjct: 20 DLSHNRLSFIKASS--MSHLQSLREVKLNNNELETIPN-LGPVSANITLLSLAGNRIVEI 76
Query: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGS- 218
LP L + L+TL+L+ N +++L + P L+ L L++N ++ + G F L +
Sbjct: 77 LPEHL-KEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSNRVTSMEPGYFDNLANT 133
Query: 219 LQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLR 278
L L L+ N IS +PP++F +L L+ L L RN I ++ F LG L L +Q N +
Sbjct: 134 LLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVT 192
Query: 279 VLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEE 338
L G F + L L HN L + +G L L+ L LS NAI + + ++
Sbjct: 193 KLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQK 252
Query: 339 LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
L +L L N+L+ L + F LS L L + N+++ + + F +L L L N
Sbjct: 253 LSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNN 309
Score = 97.8 bits (242), Expect = 2e-20
Identities = 82/277 (29%), Positives = 130/277 (46%), Gaps = 6/277 (2%)
Query: 120 LTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQN 179
L + + L+ N L + HL +L + L N+L+ +P L ++ L+LA N
Sbjct: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIP-NLGPVSANITLLSLAGN 71
Query: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQ 239
+ ++ E SL+TL LS+N +S L Q F L L+ L+L+SN ++ + P F
Sbjct: 72 RIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDN 129
Query: 240 LF-CLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH 298
L L L L RN I+ +P +F L L L L N ++ + F L L +
Sbjct: 130 LANTLLVLKLNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR 188
Query: 299 NQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQ 358
N + + +G F LSN+ L L +N +T + G L L +L+L N + + P ++
Sbjct: 189 NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWE 248
Query: 359 NLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
KL L L+ N L+ L + F +L N GN
Sbjct: 249 FCQKLSELDLTFNHLSRLDDSSF-LGLSLLNTLHIGN 284
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/205 (26%), Positives = 96/205 (46%), Gaps = 3/205 (1%)
Query: 52 KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN 111
K++ T L AF N+ + + L + GL L++L ++ ++
Sbjct: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241
Query: 112 LSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHL 171
+S + + L +L L FN L L + F L+ L +LH+ N++ + F+ L+ L
Sbjct: 242 ISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 301
Query: 172 KTLNLAQNLLAQLPEEL---FHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228
KTL+L N ++ E++ F L L+ L L N + + + F L +L+ L L N
Sbjct: 302 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNA 361
Query: 229 ISELPPQVFSQLFCLERLWLQRNAI 253
I L FSQ+ L++L L +++
Sbjct: 362 IMSLQGNAFSQMKKLQQLHLNTSSL 386
>gi|16418467 leucine-rich alpha-2-glycoprotein 1 [Homo sapiens]
Length = 347
Score = 134 bits (338), Expect = 2e-31
Identities = 99/292 (33%), Positives = 138/292 (47%), Gaps = 30/292 (10%)
Query: 157 LQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKL 216
L LP L Q + L+ L+L+ N L L E P+ L+ L L+ NAL+GLP G+F
Sbjct: 80 LTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQAS 139
Query: 217 GSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM 276
+L L L N QL LE WL L L L L N
Sbjct: 140 ATLDTLVLKEN-----------QLEVLEVSWLH-------------GLKALGHLDLSGNR 175
Query: 277 LRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDL 336
LR LP GL A+ L L L NQLET+ L L L N + L +
Sbjct: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
Query: 337 EELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIF----DTNYNLFN-LA 391
+L L+L N L + FQ L +L++L LS N L ++PEG++ N+++ +
Sbjct: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFD 295
Query: 392 LHGNPWQCDCHLAYLFNWLQQYTDRLLN-IQTYCAGPAYLKGQVVPALNEKQ 442
+ GNPW CD +L+ L+ WLQ D++ + T CAGP +KGQ + A+ + Q
Sbjct: 296 ISGNPWICDQNLSDLYRWLQAQKDKMFSQNDTRCAGPEAVKGQTLLAVAKSQ 347
Score = 92.0 bits (227), Expect = 1e-18
Identities = 76/228 (33%), Positives = 102/228 (44%), Gaps = 1/228 (0%)
Query: 86 CQFRPDAFGGLPR-LEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHL 144
CQ + G LP L V + +L N+ + L +L L+ N LE+L + +
Sbjct: 56 CQPPAEIPGYLPADTVHLAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPV 115
Query: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
L L L N L LP LFQ L TL L +N L L H L +L L LS N
Sbjct: 116 PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNR 175
Query: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
L LP G+ L+ L L N + LPP + LERL L+ N + L +
Sbjct: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
Query: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
+L +L L N L + AG F L L L++N L +V EG +A L
Sbjct: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASL 283
Score = 89.7 bits (221), Expect = 6e-18
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 11/262 (4%)
Query: 12 LLLLARPAQPCPMGC-DCFVQEVFCSD-------EELATVPLDIPPYTKNIIFVETSFTT 63
LLLLA A + DC +VF SD + A +P +P T ++ + T
Sbjct: 26 LLLLAASAWGVTLSPKDC---QVFRSDHGSSISCQPPAEIPGYLPADTVHLAVEFFNLTH 82
Query: 64 LETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSL 123
L L ++ + L P+ +P+L L++T ++ L +F +L
Sbjct: 83 LPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLPPGLFQASATL 142
Query: 124 GKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQ 183
L L N LE L L AL L L GN+L+ LP L T L+TL+L +N L
Sbjct: 143 DTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRTLDLGENQLET 202
Query: 184 LPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCL 243
LP +L L+ L L N L L + + L+ LFL+ N ++ + F L L
Sbjct: 203 LPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQPDLRYLFLNGNKLARVAAGAFQGLRQL 262
Query: 244 ERLWLQRNAITHLPLSIFASLG 265
+ L L N++ +P ++ASLG
Sbjct: 263 DMLDLSNNSLASVPEGLWASLG 284
Score = 87.4 bits (215), Expect = 3e-17
Identities = 66/201 (32%), Positives = 92/201 (45%), Gaps = 1/201 (0%)
Query: 49 PYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSS 108
P + + + T L F ++ L +V QL GL L L+++G+
Sbjct: 116 PQLRVLDLTRNALTGLPPGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNR 175
Query: 109 FLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPL 168
L + +N T L L L N LE LP L + LE LHL+GN+LQ L + L P
Sbjct: 176 LRKLPPGLLANFTLLRTLDLGENQLETLPPDLLRGPLQLERLHLEGNKLQVLGKDLLLPQ 235
Query: 169 THLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNN 228
L+ L L N LA++ F L L L LSNN+L+ +P+G++ LG D +
Sbjct: 236 PDLRYLFLNGNKLARVAAGAFQGLRQLDMLDLSNNSLASVPEGLWASLGQPNWDMRDGFD 295
Query: 229 ISELPPQVFSQLFCLERLWLQ 249
IS P L L R WLQ
Sbjct: 296 ISGNPWICDQNLSDLYR-WLQ 315
Score = 57.0 bits (136), Expect = 4e-08
Identities = 48/153 (31%), Positives = 65/153 (42%), Gaps = 24/153 (15%)
Query: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
L++++ L LPA L L L L+ N LE+++ + LR L L+ NA+T LP
Sbjct: 73 LAVEFFNLTHLPANLLQGASKLQELHLSSNGLESLSPEFLRPVPQLRVLDLTRNALTGLP 132
Query: 330 AGIFR------------------------DLEELVKLYLGSNNLTALHPALFQNLSKLEL 365
G+F+ L+ L L L N L L P L N + L
Sbjct: 133 PGLFQASATLDTLVLKENQLEVLEVSWLHGLKALGHLDLSGNRLRKLPPGLLANFTLLRT 192
Query: 366 LSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQ 398
L L +NQL TLP + L L L GN Q
Sbjct: 193 LDLGENQLETLPPDLLRGPLQLERLHLEGNKLQ 225
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 134 bits (336), Expect = 3e-31
Identities = 105/362 (29%), Positives = 158/362 (43%), Gaps = 33/362 (9%)
Query: 22 CPMGCDC-----FVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLT 76
CP C C + V CSD L+ +P ++ +T +++ S +
Sbjct: 34 CPTHCHCEPDGRMLLRVDCSDLGLSELPSNLSVFTS---YLDLSMNNIS----------- 79
Query: 77 KVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEAL 136
Q P+ L LE+L + G++ + F+ L SL L L N L +
Sbjct: 80 ----------QLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 137 PEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQ 196
P Q+L +L+SL L N + +P F L L+ L L N L ++P + F L++LQ
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 197 TLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHL 256
+ L+ N + +P FG L SL L L +N I L + F L LE L L N +
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 257 PLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLR 316
P +I +L NL L N +R +P F P L+ + N ++ V F HL LR
Sbjct: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
Query: 317 SLMLS-YNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTT 375
+L L+ + IT P L L L +++L + L L++L LS N L
Sbjct: 309 TLTLNGASQITEFPD--LTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED 366
Query: 376 LP 377
LP
Sbjct: 367 LP 368
Score = 121 bits (303), Expect = 2e-27
Identities = 102/310 (32%), Positives = 146/310 (47%), Gaps = 11/310 (3%)
Query: 86 CQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLA 145
C PD G + D G S L + ++F TS L++N N+ + LP L L
Sbjct: 38 CHCEPD--GRMLLRVDCSDLGLSELPSNLSVF---TSYLDLSMN-NISQLLPNPL-PSLR 90
Query: 146 ALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNAL 205
LE L L GN L +P+ F L LK L L N L +P E L SLQ+L+L N +
Sbjct: 91 FLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHI 150
Query: 206 SGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLG 265
S +P F L SL+ L+LD N ++E+P Q F L L+ + L N I H+P F +L
Sbjct: 151 SYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLS 210
Query: 266 NLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAI 325
+L L L N + L F L L L +N L+ LSNL+ L N I
Sbjct: 211 SLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPT-AIRTLSNLKELGFHSNNI 269
Query: 326 THLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS-KNQLTTLPEGIFDTN 384
+P F L+ ++ N + + + FQ+L +L L+L+ +Q+T P+
Sbjct: 270 RSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPD--LTGT 327
Query: 385 YNLFNLALHG 394
NL +L L G
Sbjct: 328 ANLESLTLTG 337
Score = 116 bits (291), Expect = 5e-26
Identities = 80/249 (32%), Positives = 115/249 (46%), Gaps = 25/249 (10%)
Query: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
L L N + L L L+ L LA N L +P+ F L SL+ L L NN L +P
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTF 269
L SLQ L LD+N+IS +PP FS L L LWL NA+T +P+ F SL L
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 270 LSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLP 329
++L N + +P F + LV L L +N++ ++ + F L +L +L L+YN + P
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 330 AGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFN 389
I + LS L+ L N + ++PE F N +L
Sbjct: 251 TAI-------------------------RTLSNLKELGFHSNNIRSIPEKAFVGNPSLIT 285
Query: 390 LALHGNPWQ 398
+ + NP Q
Sbjct: 286 IHFYDNPIQ 294
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/202 (25%), Positives = 80/202 (39%), Gaps = 47/202 (23%)
Query: 52 KNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRL------------ 99
K + F + ++ +AF NP+L + F + + AF LP L
Sbjct: 260 KELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQIT 319
Query: 100 -----------EDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPE---------- 138
E L +TG+ +L + + L +L L L++N+LE LP
Sbjct: 320 EFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKI 379
Query: 139 ------------GLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPE 186
FQ L +L SL+L N++ + F L L L+L+ NLL+ P
Sbjct: 380 DLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPI 439
Query: 187 ELFHPLTSLQTLKLSNNALSGL 208
H LT L+ N+AL L
Sbjct: 440 TGLHGLTHLKL--TGNHALQSL 459
>gi|86990456 leucine rich repeat transmembrane neuronal 1 [Homo
sapiens]
Length = 522
Score = 130 bits (327), Expect = 3e-30
Identities = 108/352 (30%), Positives = 161/352 (45%), Gaps = 31/352 (8%)
Query: 87 QFRPDAFGGLPRLEDLE--VTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHL 144
Q P A G P+L E + LNL T NL+ L L+L +N L L G F L
Sbjct: 30 QMLPAAPSGCPQLCRCEGRLLYCEALNL-TEAPHNLSGLLGLSLRYNSLSELRAGQFTGL 88
Query: 145 AALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNA 204
L L+L N + ++ FQ L +K L L+ N + QLP F P+ +L+++ LS N
Sbjct: 89 MQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNK 148
Query: 205 LSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASL 264
L L P +F L L L ++ NAI +P+ IF
Sbjct: 149 LQALA------------------------PDLFHGLRKLTTLHMRANAIQFVPVRIFQDC 184
Query: 265 GNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNA 324
+L FL + +N L+ L FA L L L HN L V F L +L SL L N
Sbjct: 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNK 244
Query: 325 ITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTN 384
+ + + + + L K+ L N + + P +F+ + L+ L L N+LT + I ++
Sbjct: 245 VAIVVSSL-DWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSW 303
Query: 385 YNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRL-LNIQTYCAGPAYLKGQVV 435
+L ++ L GN W C ++ L +WL + R N+Q CA P Y +G+ V
Sbjct: 304 KSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQ--CASPEYAQGEDV 353
Score = 98.6 bits (244), Expect = 1e-20
Identities = 75/287 (26%), Positives = 131/287 (45%), Gaps = 10/287 (3%)
Query: 18 PAQP--CPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
PA P CP C C + ++C L P ++ ++ + + +L G L
Sbjct: 33 PAAPSGCPQLCRCEGRLLYCEALNLTEAPHNL----SGLLGLSLRYNSLSELRAGQFTGL 88
Query: 76 TKVVFL---NTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
++ +L + +C + DAF L R+++L ++ + L F + +L + L++N
Sbjct: 89 MQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNK 148
Query: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
L+AL LF L L +LH++ N +Q +P R+FQ LK L++ N L L F L
Sbjct: 149 LQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGL 208
Query: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
L L L +N L + F +L SL L L N ++ + ++ LE++ L N
Sbjct: 209 FKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVA-IVVSSLDWVWNLEKMDLSGNE 267
Query: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHN 299
I ++ +F ++ +L L L N L + + L ++L N
Sbjct: 268 IEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 129 bits (324), Expect = 7e-30
Identities = 113/403 (28%), Positives = 174/403 (43%), Gaps = 27/403 (6%)
Query: 16 ARPAQPCPMGCDCFVQEVFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
A P P CD + V CS + L VP + +T+ + + T L AF + P L
Sbjct: 25 APPLCAAPCSCDGD-RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFL 83
Query: 76 TKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEA 135
++ L P A GL L+ L + + + + L++L L L+ N + +
Sbjct: 84 EELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS 143
Query: 136 LPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSL 195
+PE F+ L L L L N L +P L L+ L LA N ++ +P+ F L+SL
Sbjct: 144 VPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
Query: 196 QTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITH 255
L L NN + L Q F L +L+ L L+ NN+ E PQ L L+ L N+I+
Sbjct: 204 VVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF-PQAIKALPSLKELGFHSNSISV 262
Query: 256 LPLSIF----------------ASLGNLTFLSL-QWNMLRVLPAGLFAHTPCLVG----- 293
+P F + +GN F +L + L + A + P L G
Sbjct: 263 IPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLE 322
Query: 294 -LSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTAL 352
L+LT ++ ++ LR+L LSYN I LP+ F L ++ L N + +
Sbjct: 323 SLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHALEEISLQRNQIYQI 380
Query: 353 HPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
FQ L L +L LS+N + + F T + NL + N
Sbjct: 381 KEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFN 423
Score = 112 bits (281), Expect = 7e-25
Identities = 79/264 (29%), Positives = 124/264 (46%), Gaps = 28/264 (10%)
Query: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
L A+PEGL A ++L + N + LP F+ L+ L LA N L+ + + L
Sbjct: 48 LTAVPEGLS---AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGL 104
Query: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
L+ L L NN L +P L +LQ L LD+N+I+ +P F L L LWL N+
Sbjct: 105 KELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNS 164
Query: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
+T +P+ ++L L L+L N + +P F + LV L L +N++ ++++ F L
Sbjct: 165 LTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGL 224
Query: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
NL +L L+YN + P I + L L+ L N
Sbjct: 225 DNLETLDLNYNNLGEFPQAI-------------------------KALPSLKELGFHSNS 259
Query: 373 LTTLPEGIFDTNYNLFNLALHGNP 396
++ +P+G FD N L + L+ NP
Sbjct: 260 ISVIPDGAFDGNPLLRTIHLYDNP 283
Score = 110 bits (276), Expect = 3e-24
Identities = 88/299 (29%), Positives = 142/299 (47%), Gaps = 26/299 (8%)
Query: 91 DAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESL 150
D+F GL +L L + +S + + SNL +L LTL N + ++P+ F +L++L L
Sbjct: 147 DSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVL 206
Query: 151 HLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQ 210
HL N++++L + F L +L+TL+L N L + P+ + L SL+ L +N++S +P
Sbjct: 207 HLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAI-KALPSLKELGFHSNSISVIPD 265
Query: 211 GVFGKLGSLQELFLDSNNISELPPQVFSQL-----------------------FCLERLW 247
G F L+ + L N +S + F L LE L
Sbjct: 266 GAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLT 325
Query: 248 LQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEG 307
L I+ +P ++ L L L +N +R LP+ H L +SL NQ+ + EG
Sbjct: 326 LTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPSFNGCHA--LEEISLQRNQIYQIKEG 383
Query: 308 TFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELL 366
TF L +LR L LS N I + + F L + L + N LT+ L++L+L+
Sbjct: 384 TFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLV 442
Score = 63.5 bits (153), Expect = 5e-10
Identities = 49/194 (25%), Positives = 87/194 (44%), Gaps = 6/194 (3%)
Query: 30 VQEVFCSDEELATVP---LDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLC 86
++E+ ++ +P D P + I + + + AF + +L +V +
Sbjct: 250 LKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASMV 309
Query: 87 QFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAA 146
Q P+ G + LE L +TG+ ++ N+ L L L++N + LP F A
Sbjct: 310 QQFPNLTGTV-HLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS--FNGCHA 366
Query: 147 LESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALS 206
LE + LQ NQ+ + FQ L L+ L+L++NL+ ++ F L + L +S N L+
Sbjct: 367 LEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSFNELT 426
Query: 207 GLPQGVFGKLGSLQ 220
P L L+
Sbjct: 427 SFPTEGLNGLNQLK 440
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 129 bits (323), Expect = 9e-30
Identities = 108/333 (32%), Positives = 146/333 (43%), Gaps = 31/333 (9%)
Query: 101 DLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGN-QLQA 159
DL+ G FL F L SL +L+L N L + G F+ L L L L N L+
Sbjct: 68 DLDRNGLRFLG--ERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRY 125
Query: 160 LPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSL 219
L R F L+ L+ L+LA L +PE L L +L+ L +N +P + G
Sbjct: 126 LHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRG----- 180
Query: 220 QELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRV 279
L L L+R I + S L L LSLQ N +R
Sbjct: 181 --------------------LANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRA 220
Query: 280 LPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEEL 339
+ AG F L L L N L + F L LR+L L NA+ + F DL EL
Sbjct: 221 VHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAEL 280
Query: 340 VKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGNPWQC 399
LYL N++ + FQNLS L L L+ N+LT L F + L L L NPW C
Sbjct: 281 ELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCC 340
Query: 400 DCHLAYLFNWLQQYTDRLLNIQTYCAGPAYLKG 432
DC L +L +W++ + R+ ++ CA P + G
Sbjct: 341 DCRLEWLRDWMEG-SGRVTDVP--CASPGSVAG 370
Score = 115 bits (288), Expect = 1e-25
Identities = 93/309 (30%), Positives = 136/309 (44%), Gaps = 13/309 (4%)
Query: 2 LPGAWLLWTSLLLLARPAQPCPMGCDCFVQE----VFCSDEELATVPLDIPPYTKNIIFV 57
LP AW + A+ CP C C E V C L VP ++P +I
Sbjct: 18 LPSAWAVGAC-------ARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLD 70
Query: 58 ETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLN-LSTNI 116
L RAFG+ P+L ++ + L P AF GLPRL +L + + L L
Sbjct: 71 RNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHART 130
Query: 117 FSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNL 176
F+ L+ L +L L L ++PE L L AL L N + +P L + L +L +L
Sbjct: 131 FAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGAL-RGLANLTHAHL 189
Query: 177 AQNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQV 236
+ + + L L++L L N + + G FG G L+ L L+ N ++ELP
Sbjct: 190 ERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADA 249
Query: 237 FSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSL 296
F L L L L NA+ + + FA L L L L N + + G F + L+ L L
Sbjct: 250 FRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHL 309
Query: 297 THNQLETVA 305
N+L +A
Sbjct: 310 NGNRLTVLA 318
Score = 74.7 bits (182), Expect = 2e-13
Identities = 52/162 (32%), Positives = 74/162 (45%)
Query: 90 PDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALES 149
P A GL L + ++++ L L L+L N + A+ G F LE
Sbjct: 175 PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEH 234
Query: 150 LHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGLP 209
L L N L LP F+ L L+TLNL N L ++ F L L+ L L N+++ +
Sbjct: 235 LLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVE 294
Query: 210 QGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251
+G F L L L L+ N ++ L F F L RL+L RN
Sbjct: 295 EGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,900,778
Number of Sequences: 37866
Number of extensions: 912314
Number of successful extensions: 6003
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 209
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 2116
Number of HSP's gapped (non-prelim): 1413
length of query: 545
length of database: 18,247,518
effective HSP length: 107
effective length of query: 438
effective length of database: 14,195,856
effective search space: 6217784928
effective search space used: 6217784928
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.