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Search of human proteins with 32967260
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
(548 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens] 1073 0.0
gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens] 1052 0.0
gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens] 1052 0.0
gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens] 1052 0.0
gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens] 1029 0.0
gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens] 973 0.0
gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens] 970 0.0
gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens] 970 0.0
gi|4506467 radixin [Homo sapiens] 438 e-123
gi|4505257 moesin [Homo sapiens] 432 e-121
gi|161702986 ezrin [Homo sapiens] 426 e-119
gi|21614499 ezrin [Homo sapiens] 426 e-119
gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens] 193 4e-49
gi|150010540 FERM domain containing 4B [Homo sapiens] 127 3e-29
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 126 6e-29
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 126 6e-29
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 126 6e-29
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 124 2e-28
gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Ho... 121 1e-27
gi|223941879 protein tyrosine phosphatase, non-receptor type 3 i... 120 4e-27
gi|223941876 protein tyrosine phosphatase, non-receptor type 3 i... 120 4e-27
gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosi... 117 3e-26
gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis... 117 3e-26
gi|116063562 FERM domain containing 4A [Homo sapiens] 114 2e-25
gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosi... 111 1e-24
gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform... 110 3e-24
gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform... 110 3e-24
gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens] 109 6e-24
gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo s... 106 6e-23
gi|207113199 erythrocyte membrane protein band 4.1-like 2 isofor... 106 6e-23
>gi|32967260 neurofibromin 2 isoform 5 [Homo sapiens]
Length = 548
Score = 1073 bits (2774), Expect = 0.0
Identities = 548/548 (100%), Positives = 548/548 (100%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60
Query: 61 ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120
ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF
Sbjct: 61 ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120
Query: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180
LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
Sbjct: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180
Query: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240
AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV
Sbjct: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240
Query: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300
FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE
Sbjct: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300
Query: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360
KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA
Sbjct: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360
Query: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420
AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR
Sbjct: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420
Query: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480
EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE
Sbjct: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480
Query: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540
KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA
Sbjct: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540
Query: 541 QGRRPICI 548
QGRRPICI
Sbjct: 541 QGRRPICI 548
>gi|32967254 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 1052 bits (2721), Expect = 0.0
Identities = 548/590 (92%), Positives = 548/590 (92%), Gaps = 42/590 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78
VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
Query: 79 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 138
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
Query: 139 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 198
PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
Query: 199 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 258
LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
Query: 259 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 318
IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
Query: 319 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 378
LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
Query: 379 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 438
EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
Query: 439 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 498
YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
Query: 499 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 548
ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
>gi|32967266 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 1052 bits (2721), Expect = 0.0
Identities = 548/590 (92%), Positives = 548/590 (92%), Gaps = 42/590 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78
VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
Query: 79 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 138
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
Query: 139 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 198
PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
Query: 199 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 258
LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
Query: 259 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 318
IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
Query: 319 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 378
LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
Query: 379 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 438
EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
Query: 439 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 498
YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
Query: 499 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 548
ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
>gi|32451486 neurofibromin 2 isoform 2 [Homo sapiens]
Length = 590
Score = 1052 bits (2721), Expect = 0.0
Identities = 548/590 (92%), Positives = 548/590 (92%), Gaps = 42/590 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78
VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
Query: 79 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 138
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
Query: 139 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 198
PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
Query: 199 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 258
LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
Query: 259 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 318
IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
Query: 319 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 378
LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
Query: 379 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 438
EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
Query: 439 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 498
YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
Query: 499 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 548
ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRRPICI 590
>gi|4557795 neurofibromin 2 isoform 1 [Homo sapiens]
Length = 595
Score = 1029 bits (2661), Expect = 0.0
Identities = 538/586 (91%), Positives = 539/586 (91%), Gaps = 42/586 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78
VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
Query: 79 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 138
QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMT 180
Query: 139 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 198
PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG
Sbjct: 181 PEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALG 240
Query: 199 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 258
LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC
Sbjct: 241 LHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLC 300
Query: 259 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 318
IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL
Sbjct: 301 IGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRL 360
Query: 319 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 378
LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE
Sbjct: 361 LQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTE 420
Query: 379 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 438
EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT
Sbjct: 421 EEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPT 480
Query: 439 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 498
YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN
Sbjct: 481 YPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLN 540
Query: 499 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQAQGRR 544
ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKK Q +
Sbjct: 541 ELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAK 586
>gi|32967262 neurofibromin 2 isoform 6 [Homo sapiens]
Length = 549
Score = 973 bits (2516), Expect = 0.0
Identities = 509/549 (92%), Positives = 517/549 (94%), Gaps = 1/549 (0%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHF-LAKFY 59
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE+ + V L + +
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 60 PENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 119
+ + + +VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRG 120
Query: 120 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 179
FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY
Sbjct: 121 FLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNY 180
Query: 180 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 239
FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID
Sbjct: 181 FAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKID 240
Query: 240 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 299
VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR
Sbjct: 241 VFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAR 300
Query: 300 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 359
EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK
Sbjct: 301 EKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQK 360
Query: 360 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 419
AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA
Sbjct: 361 AAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEA 420
Query: 420 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 479
REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI
Sbjct: 421 REAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEI 480
Query: 480 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 539
EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ
Sbjct: 481 EKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQ 540
Query: 540 AQGRRPICI 548
AQGRRPICI
Sbjct: 541 AQGRRPICI 549
>gi|32967514 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 970 bits (2507), Expect = 0.0
Identities = 507/548 (92%), Positives = 507/548 (92%), Gaps = 41/548 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
Query: 61 ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120
VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF
Sbjct: 39 -------------------VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 79
Query: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180
LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
Sbjct: 80 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 139
Query: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240
AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV
Sbjct: 140 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 199
Query: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300
FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE
Sbjct: 200 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 259
Query: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360
KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA
Sbjct: 260 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 319
Query: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420
AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR
Sbjct: 320 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 379
Query: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480
EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE
Sbjct: 380 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 439
Query: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540
KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA
Sbjct: 440 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 499
Query: 541 QGRRPICI 548
QGRRPICI
Sbjct: 500 QGRRPICI 507
>gi|32967264 neurofibromin 2 isoform 7 [Homo sapiens]
Length = 507
Score = 970 bits (2507), Expect = 0.0
Identities = 507/548 (92%), Positives = 507/548 (92%), Gaps = 41/548 (7%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEVLDHDVSKEEPVTFHFLAKFYP 60
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
Query: 61 ENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 120
VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF
Sbjct: 39 -------------------VKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGF 79
Query: 121 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 180
LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF
Sbjct: 80 LAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYF 139
Query: 181 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 240
AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV
Sbjct: 140 AIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDV 199
Query: 241 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 300
FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE
Sbjct: 200 FKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLARE 259
Query: 301 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 360
KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA
Sbjct: 260 KQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKA 319
Query: 361 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 420
AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR
Sbjct: 320 AEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAR 379
Query: 421 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 480
EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE
Sbjct: 380 EAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIE 439
Query: 481 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 540
KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA
Sbjct: 440 KEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKPQA 499
Query: 541 QGRRPICI 548
QGRRPICI
Sbjct: 500 QGRRPICI 507
>gi|4506467 radixin [Homo sapiens]
Length = 583
Score = 438 bits (1126), Expect = e-123
Identities = 237/569 (41%), Positives = 349/569 (61%), Gaps = 53/569 (9%)
Query: 19 PKTFTVRIVTMDAEMEF------------------------------------------- 35
PK VR+ TMDAE+EF
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKL 61
Query: 36 NCEVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
N +V DV KE P+ F F AKF+PE+ EEL+QEITQ LFFLQVK+ IL+++IYCPPE
Sbjct: 62 NKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPET 121
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
+VLLASYAVQAKYGDY+ +HK G+LA + LLP+RV+ +++T E WEERI W+ EHRG
Sbjct: 122 AVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRG 181
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
R+++ MEYLKIAQDLEMYGVNYF I+NKKGTEL LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFP 241
Query: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
Query: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 335
VQQMKAQAREEK +KQ+ER +L EK+ RE AE+ ++ +ER ++ E E +++
Sbjct: 302 VQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLKQIEEQTIKA 361
Query: 336 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIK----ATAIRTEEEKRLMEQKVLEA 391
++ + KA ++E K ++A E+E + + A A + ++ + EQ E
Sbjct: 362 QKELEEQTRKALELDQERKRAKEEAERLEKERRAAEEAKSAIAKQAADQMKNQEQLAAEL 421
Query: 392 EVLALKMA---EESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 448
K+A E +++ +EA + + A+E + K++L + + P PP P+ P
Sbjct: 422 AEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPP 481
Query: 449 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 508
+ + S + + + ++ E+E+V +K++ +++QL L +E+ +
Sbjct: 482 TENEHDEHDENNAEASAELSNEGV--MNHRSEEERVTETQKNERVKKQLQALSSELAQAR 539
Query: 509 LKERETALDILHNENSDRGGSSKHNTIKK 537
+ ++T D+LH EN + G K+ T+++
Sbjct: 540 DETKKTQNDVLHAENV-KAGRDKYKTLRQ 567
>gi|4505257 moesin [Homo sapiens]
Length = 577
Score = 432 bits (1112), Expect = e-121
Identities = 245/569 (43%), Positives = 351/569 (61%), Gaps = 59/569 (10%)
Query: 19 PKTFTVRIVTMDAEMEF------------------------------------------- 35
PKT +VR+ TMDAE+EF
Sbjct: 2 PKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKGFSTWLKL 61
Query: 36 NCEVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
N +V DV KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL++ IYCPPE
Sbjct: 62 NKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPET 121
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
+VLLASYAVQ+KYGD++ VHK G+LA ++LLP+RV+ +++ + WEERI W+ EHRG
Sbjct: 122 AVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRG 181
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
R++A +EYLKIAQDLEMYGVNYF+I+NKKG+EL LGVDALGL+IY+ +RLTPKI FP
Sbjct: 182 MLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFP 241
Query: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK IL LC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIE 301
Query: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELER-------RLLQMKEEATMA 328
VQQMKAQAREEK +KQMER L EK+ RE AE+ ++++ER RL Q++E+ A
Sbjct: 302 VQQMKAQAREEKHQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLKQIEEQTKKA 361
Query: 329 NEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKV 388
+ L A L ++ + + EA+ LA++ EAE+ + A + ++K+ EQ
Sbjct: 362 QQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKE---ALLQASRDQKKTQEQLA 418
Query: 389 LEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAP 448
LE L ++++ R K+ + + Q+A+ + ++ E+ T + P + PA
Sbjct: 419 LEMAELTARISQLEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMSTPHVAE-PAE 477
Query: 449 LPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALK 508
D N G S D + M + E+E+ EK++ +Q+ L L +E+ +
Sbjct: 478 NEQDEQDEN--GAEASADLRADAMAK--DRSEEERTTEAEKNERVQKHLKALTSELANAR 533
Query: 509 LKERETALDILHNENSDRGGSSKHNTIKK 537
+ ++TA D++H EN R G K+ T+++
Sbjct: 534 DESKKTANDMIHAENM-RLGRDKYKTLRQ 561
Score = 33.5 bits (75), Expect = 0.52
Identities = 35/158 (22%), Positives = 70/158 (44%), Gaps = 14/158 (8%)
Query: 273 SLEVQQMKAQ------AREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEAT 326
+LE+ ++ A+ AR++K + +E Q+ A+ ++E+ E+TR EL+ +
Sbjct: 418 ALEMAELTARISQLEMARQKKESEAVEWQQKAQ--MVQEDLEKTRAELKTAMSTPHVAEP 475
Query: 327 MANEALMRSEE----TADLLAEKA--QITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE 380
NE + E +ADL A+ +EEE A+K ++ ++ + + +E
Sbjct: 476 AENEQDEQDENGAEASADLRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDE 535
Query: 381 KRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQE 418
+ ++ AE + L + R KQ + E
Sbjct: 536 SKKTANDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDE 573
>gi|161702986 ezrin [Homo sapiens]
Length = 586
Score = 426 bits (1094), Expect = e-119
Identities = 245/576 (42%), Positives = 352/576 (61%), Gaps = 64/576 (11%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---------------------------------------- 38
PK VR+ TMDAE+EF +
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 39 ---VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
V +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
Query: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 335
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
Query: 336 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 394
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
Query: 395 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 451
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
Query: 452 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 501
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
Query: 502 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 537
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
>gi|21614499 ezrin [Homo sapiens]
Length = 586
Score = 426 bits (1094), Expect = e-119
Identities = 245/576 (42%), Positives = 352/576 (61%), Gaps = 64/576 (11%)
Query: 19 PKTFTVRIVTMDAEMEFNCE---------------------------------------- 38
PK VR+ TMDAE+EF +
Sbjct: 2 PKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKL 61
Query: 39 ---VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEA 95
V +V KE P+ F F AKFYPE+ EEL+Q+ITQ LFFLQVK+ IL ++IYCPPE
Sbjct: 62 DKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPET 121
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
+VLL SYAVQAK+GDY+ VHK G+L+ E L+P+RV++ +++T + WE+RI W+AEHRG
Sbjct: 122 AVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRG 181
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFP 215
+D A +EYLKIAQDLEMYG+NYF I+NKKGT+L LGVDALGL+IY+ +++LTPKI FP
Sbjct: 182 MLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFP 241
Query: 216 WNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLE 275
W+EIRNIS++DK+F IKP+DKK F F + +LR+NK ILQLC+GNH+L+MRRRK D++E
Sbjct: 242 WSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIE 301
Query: 276 VQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRS 335
VQQMKAQAREEK +KQ+ERQ+L EK+ RE ER ++++ R ++ E ++
Sbjct: 302 VQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKA 361
Query: 336 EETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEE-KRLMEQKVLEAEVL 394
E ++A EEE K +A E + ++ + A+R +EE +R ++ E L
Sbjct: 362 ERELSEQIQRALQLEEERK----RAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQL 417
Query: 395 ALKMAEESERRA--KEADQLKQDLQEAREAERRAKQKLLE-IATKPTYPPMNPIPAPLPP 451
A ++AE + + A +EA + K+D E E + RAK+ + + TK + P P PP
Sbjct: 418 AAELAEYTAKIALLEEARRRKED--EVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPP 475
Query: 452 DI--PSFNLIGDSLSFDFKDTD--MKRLSME------IEKEKVEYMEKSKHLQEQLNELK 501
+ P + +SL + + LS E E++++ EK++ +Q QL L
Sbjct: 476 PVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLS 535
Query: 502 TEIEALKLKERETALDILHNENSDRGGSSKHNTIKK 537
+E+ + + + T DI+HNEN R G K+ T+++
Sbjct: 536 SELSQARDENKRTHNDIIHNENM-RQGRDKYKTLRQ 570
>gi|32967268 neurofibromin 2 isoform 8 [Homo sapiens]
Length = 165
Score = 193 bits (490), Expect = 4e-49
Identities = 107/149 (71%), Positives = 107/149 (71%), Gaps = 42/149 (28%)
Query: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE---------------------- 38
MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCE
Sbjct: 1 MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETW 60
Query: 39 --------------------VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 78
VLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL
Sbjct: 61 FFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFL 120
Query: 79 QVKKQILDEKIYCPPEASVLLASYAVQAK 107
QVKKQILDEKIYCPPEASVLLASYAVQAK
Sbjct: 121 QVKKQILDEKIYCPPEASVLLASYAVQAK 149
>gi|150010540 FERM domain containing 4B [Homo sapiens]
Length = 1034
Score = 127 bits (318), Expect = 3e-29
Identities = 106/442 (23%), Positives = 208/442 (47%), Gaps = 48/442 (10%)
Query: 33 MEFNCEVLDHDVSKEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 91
++ + VLDHD+ K+ P HF +FY E+ L + T LFFL K + +I
Sbjct: 114 LQLDHRVLDHDLPKKPGPTILHFAVRFYIESISF-LKDKTTVELFFLNAKACVHKGQIEV 172
Query: 92 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEM--WEERITAW 149
E LA++ +Q GDY + R L P + + Q P + E+R+
Sbjct: 173 ESETIFKLAAFILQEAKGDYTSDENARKDLKTLPAFPTKTL---QEHPSLAYCEDRVIEH 229
Query: 150 YAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLT 209
Y + +G R +A ++Y+KI + L YGV+Y+A+++K+G LG+ G+ YD ++++
Sbjct: 230 YLKIKGLTRGQAVVQYMKIVEALPTYGVHYYAVKDKQGLPWWLGISYKGIGQYDIQDKVK 289
Query: 210 PKISFPWNEIRNISYSDKEFTIKPLD-KKIDVFK--FNSSKLRVN---------KLILQL 257
P+ F W ++ N+ + +K+F ++ D ++I V + F S L V K I +
Sbjct: 290 PRKLFQWKQLENLYFREKKFAVEVHDPRRISVSRRTFGQSGLFVQTWYANSSLIKSIWVM 349
Query: 258 CIGNHDLFMRRRKA-----DSLEVQQMKAQAREEKARKQMERQRLAREKQM--------- 303
I H ++ R+++ + + ++ E ++ + L + Q
Sbjct: 350 AISQHQFYLDRKQSKAKIPSARSLDEIAMDLTETGTQRASKLVTLEAKSQFIMASNGSLI 409
Query: 304 ---REEAERTRDELERRLLQMKEEATMANEALMRS-EETADLLAEKAQITEEEAKLLAQK 359
+++E + ++ ++L++K++ + E L++ EE + +A++T + K
Sbjct: 410 SSGSQDSEVSEEQKREKILELKKKEKLLQEKLLKKVEELKKICLREAELTGKMPKEYPLN 469
Query: 360 AAEAEQEMQRIKATAIR-------TEEEKRLMEQKVLEAE-VLALKMAEESERRAKEADQ 411
E +++R TA + +EE+ L E LE+ ++ K+ E +++ A E D
Sbjct: 470 IGEKPPQVRRRVGTAFKLDDNLLPSEEDPALQE---LESNFLIQQKLVEAAKKLANEPDL 526
Query: 412 LKQDLQEAREAERRAKQKLLEI 433
K ++ ++ A +KL EI
Sbjct: 527 CKTVKKKRKQDYTDAMKKLQEI 548
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 126 bits (316), Expect = 6e-29
Identities = 90/295 (30%), Positives = 148/295 (50%), Gaps = 21/295 (7%)
Query: 46 KEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQILDEKIYCPPEA 95
KEEP T F KF+ ++ L+Q +T H ++LQ++K IL+E+++C E
Sbjct: 641 KEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDET 698
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
S+LLAS A+QA+YGDY P VH + E LP RV+ ++ +E + + + G
Sbjct: 699 SLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEELPKLHNTYVG 756
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYDPENRL-TPKI 212
+ E E+E+LK+ Q L YGV++ + K T +LLGV + G+ +++ N + T +
Sbjct: 757 ASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVL 816
Query: 213 SFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKAD 272
FPW E + IS+S K+ T++ I F + ++ + +L LC H ++ R
Sbjct: 817 RFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Query: 273 SLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLLQMKEE 324
S + Q +A Q E R + R A T ++L R L ++ E
Sbjct: 876 SNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAE 930
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 126 bits (316), Expect = 6e-29
Identities = 90/295 (30%), Positives = 148/295 (50%), Gaps = 21/295 (7%)
Query: 46 KEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQILDEKIYCPPEA 95
KEEP T F KF+ ++ L+Q +T H ++LQ++K IL+E+++C E
Sbjct: 641 KEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDET 698
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
S+LLAS A+QA+YGDY P VH + E LP RV+ ++ +E + + + G
Sbjct: 699 SLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEELPKLHNTYVG 756
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYDPENRL-TPKI 212
+ E E+E+LK+ Q L YGV++ + K T +LLGV + G+ +++ N + T +
Sbjct: 757 ASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVL 816
Query: 213 SFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKAD 272
FPW E + IS+S K+ T++ I F + ++ + +L LC H ++ R
Sbjct: 817 RFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Query: 273 SLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLLQMKEE 324
S + Q +A Q E R + R A T ++L R L ++ E
Sbjct: 876 SNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAE 930
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13
isoform 2 [Homo sapiens]
Length = 2466
Score = 126 bits (316), Expect = 6e-29
Identities = 90/295 (30%), Positives = 148/295 (50%), Gaps = 21/295 (7%)
Query: 46 KEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQILDEKIYCPPEA 95
KEEP T F KF+ ++ L+Q +T H ++LQ++K IL+E+++C E
Sbjct: 641 KEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDET 698
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
S+LLAS A+QA+YGDY P VH + E LP RV+ ++ +E + + + G
Sbjct: 699 SLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEELPKLHNTYVG 756
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYDPENRL-TPKI 212
+ E E+E+LK+ Q L YGV++ + K T +LLGV + G+ +++ N + T +
Sbjct: 757 ASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVL 816
Query: 213 SFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKAD 272
FPW E + IS+S K+ T++ I F + ++ + +L LC H ++ R
Sbjct: 817 RFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Query: 273 SLEVQQMKAQAREEKARKQMERQR---LAREKQMREEAERTRDELERRLLQMKEE 324
S + Q +A Q E R + R A T ++L R L ++ E
Sbjct: 876 SNQDAQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAE 930
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 124 bits (311), Expect = 2e-28
Identities = 80/242 (33%), Positives = 132/242 (54%), Gaps = 20/242 (8%)
Query: 46 KEEP---------VTFHFLAKFYPENAEEELVQE-ITQHLFFLQVKKQILDEKIYCPPEA 95
KEEP T F KF+ ++ L+Q +T H ++LQ++K IL+E+++C E
Sbjct: 641 KEEPKKKTKATVNFTLFFRIKFFMDDVS--LIQHTLTCHQYYLQLRKDILEERMHCDDET 698
Query: 96 SVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRG 155
S+LLAS A+QA+YGDY P VH + E LP RV+ ++ +E + + + G
Sbjct: 699 SLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPARVMEKLDLS--YIKEELPKLHNTYVG 756
Query: 156 RARDEAEMEYLKIAQDLEMYGVNYFAI--RNKKGTELLLGVDALGLHIYDPENRL-TPKI 212
+ E E+E+LK+ Q L YGV++ + K T +LLGV + G+ +++ N + T +
Sbjct: 757 ASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVL 816
Query: 213 SFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNH--DLFMRRRK 270
FPW E + IS+S K+ T++ I F + ++ + +L LC H L MR R+
Sbjct: 817 RFPWRETKKISFSKKKITLQNTSDGIK-HGFQTDNSKICQYLLHLCSYQHKFQLQMRARQ 875
Query: 271 AD 272
++
Sbjct: 876 SN 877
>gi|4506295 protein tyrosine phosphatase, non-receptor type 4 [Homo
sapiens]
Length = 926
Score = 121 bits (304), Expect = 1e-27
Identities = 72/226 (31%), Positives = 124/226 (54%), Gaps = 16/226 (7%)
Query: 44 VSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYA 103
+ + P + +F KF+ + + L +E T++ +FLQ+K+ IL ++ CP + LLAS+A
Sbjct: 95 LKRGSPYSLNFRVKFFVSDPNK-LQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFA 153
Query: 104 VQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEM 163
VQ++ GDYD S + G+L+ +P + P+ +E+ I + +H G + EAE
Sbjct: 154 VQSELGDYDQSENLSGYLSDYSFIPNQ--------PQDFEKEIAKLHQQHIGLSPAEAEF 205
Query: 164 EYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNIS 223
YL A+ LE+YGV + R++ E+++GV + G+ IY R+ +FPW +I IS
Sbjct: 206 NYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMN---TFPWLKIVKIS 262
Query: 224 YSDKEFTI---KPL-DKKIDVFKFNSSKLRVNKLILQLCIGNHDLF 265
+ K+F I K L + + + FN R K + + C+ +H F
Sbjct: 263 FKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFF 308
>gi|223941879 protein tyrosine phosphatase, non-receptor type 3
isoform 2 [Homo sapiens]
Length = 868
Score = 120 bits (300), Expect = 4e-27
Identities = 68/225 (30%), Positives = 120/225 (53%), Gaps = 16/225 (7%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P T HF +F+ + L QE T+HL+FLQ+K I + ++ CP ++V+LASYAVQ+ +
Sbjct: 100 PCTLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDY+ S+H G+L+ +P + E + ++ + + +H G + EAE Y+ I
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINI 210
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L+ YGV + R+ +L++G+ + G+ +Y + +PW I IS+ K+
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY---RKYICTSFYPWVNILKISFKRKK 267
Query: 229 FTI----KPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR 269
F I K + + + FN R K + + C+ +H F ++
Sbjct: 268 FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|223941876 protein tyrosine phosphatase, non-receptor type 3
isoform 1 [Homo sapiens]
Length = 913
Score = 120 bits (300), Expect = 4e-27
Identities = 68/225 (30%), Positives = 120/225 (53%), Gaps = 16/225 (7%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P T HF +F+ + L QE T+HL+FLQ+K I + ++ CP ++V+LASYAVQ+ +
Sbjct: 100 PCTLHFRVRFFIPDPNT-LQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHF 158
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDY+ S+H G+L+ +P + E + ++ + + +H G + EAE Y+ I
Sbjct: 159 GDYNSSIHHPGYLSDSHFIPDQ--------NEDFLTKVESLHEQHSGLKQSEAESCYINI 210
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L+ YGV + R+ +L++G+ + G+ +Y + +PW I IS+ K+
Sbjct: 211 ARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY---RKYICTSFYPWVNILKISFKRKK 267
Query: 229 FTI----KPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR 269
F I K + + + FN R K + + C+ +H F ++
Sbjct: 268 FFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK 312
>gi|42716289 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 1 [Homo sapiens]
Length = 775
Score = 117 bits (293), Expect = 3e-26
Identities = 88/376 (23%), Positives = 169/376 (44%), Gaps = 18/376 (4%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q++
Sbjct: 244 PWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 302
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDYDP +H +++ +L P + L EE++ + +R +A++E+L+
Sbjct: 303 GDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLEN 354
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 355 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSS 411
Query: 229 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAR 284
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 412 FFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGS 470
Query: 285 EEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAE 344
+ + + + Q + A +R + + A + A T+
Sbjct: 471 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIT 530
Query: 345 KAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESE 403
+ Q+ E A+K + + + +KA + +E E + EA K EE +
Sbjct: 531 QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKDLDKSQEEIK 590
Query: 404 RRAKEADQLKQDLQEA 419
+ +LK++ E+
Sbjct: 591 KHHASISELKKNFMES 606
>gi|4758274 erythrocyte membrane protein band 4.1 (elliptocytosis 1,
RH-linked) isoform 3 [Homo sapiens]
Length = 588
Score = 117 bits (293), Expect = 3e-26
Identities = 91/409 (22%), Positives = 183/409 (44%), Gaps = 22/409 (5%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q++
Sbjct: 70 PWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 128
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDYDP +H +++ +L P + L EE++ + +R +A++E+L+
Sbjct: 129 GDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSS 237
Query: 229 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAR 284
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 238 FFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGS 296
Query: 285 EEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAE 344
+ + + + Q + A +R + + A + A T+
Sbjct: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIT 356
Query: 345 KAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESE 403
+ Q+ E A+K + + + +KA + +E E + EA + +
Sbjct: 357 QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKKKRERLDGEN 416
Query: 404 RRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPD 452
+ ++ + +DL +++E ++ + E+ K + M +P P P +
Sbjct: 417 IYIRHSNLMLEDLDKSQEEIKKHHASISEL--KKNF--MESVPEPRPSE 461
>gi|116063562 FERM domain containing 4A [Homo sapiens]
Length = 1039
Score = 114 bits (286), Expect = 2e-25
Identities = 103/438 (23%), Positives = 192/438 (43%), Gaps = 39/438 (8%)
Query: 33 MEFNCEVLDHDVSKEE-PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYC 91
++ + VL+HD K+ PV +F +FY E+ L T LFFL K I E I
Sbjct: 75 LQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISY-LKDNATIELFFLNAKSCIYKELIDV 133
Query: 92 PPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYA 151
E LASY +Q GD+ + R L + LP + + + E+R+ Y
Sbjct: 134 DSEVVFELASYILQEAKGDFSSNEVVRSDLKKLPALPTQALKEHPSLAYC-EDRVIEHYK 192
Query: 152 EHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPK 211
+ G+ R +A + Y+ I + L YGV+Y+A+++K+G LG+ G+ YD +++ P+
Sbjct: 193 KLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPR 252
Query: 212 ISFPWNEIRNISYSDKEFTIK---PLDKKIDVFKFNSSKLRVN---------KLILQLCI 259
F W ++ N+ + +K+F+++ P + F S + V+ K I + I
Sbjct: 253 KIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAI 312
Query: 260 GNHDLFMRRRKADS-----LEVQQMKAQAREEKARKQMERQRLAREKQM----------- 303
H ++ R+++ S + ++ E K + + + ++
Sbjct: 313 SQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSS 372
Query: 304 -REEAERTRDELERRLLQMKEEATMANEAL-MRSEETADLLAEKAQITEEEAKLLAQKAA 361
+E++ ++ + L +K E L R EE L +A++T +
Sbjct: 373 GSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEYPLDPG 432
Query: 362 EAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMA------EESERRAKEADQLKQD 415
E ++R TA + +E+K L + + E E L + A E + R A + + K+
Sbjct: 433 EEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEAARRLASDPNVSKKL 492
Query: 416 LQEAREAERRAKQKLLEI 433
++ + + A +KL EI
Sbjct: 493 KKQRKTSYLNALKKLQEI 510
>gi|42716291 erythrocyte membrane protein band 4.1 (elliptocytosis
1, RH-linked) isoform 2 [Homo sapiens]
Length = 641
Score = 111 bits (278), Expect = 1e-24
Identities = 82/348 (23%), Positives = 157/348 (45%), Gaps = 18/348 (5%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P F F KFYP + + L ++IT++ LQ+++ I+ ++ C LL SY +Q++
Sbjct: 70 PWNFTFNVKFYPPDPAQ-LTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSEL 128
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDYDP +H +++ +L P + L EE++ + +R +A++E+L+
Sbjct: 129 GDYDPELHGVDYVSDFKLAPNQTKEL--------EEKVMELHKSYRSMTPAQADLEFLEN 180
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L MYGV+ ++ +G +++LGV + GL +Y + R+ FPW ++ ISY
Sbjct: 181 AKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRIN---RFPWPKVLKISYKRSS 237
Query: 229 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAR 284
F IK + + ++ F R K + ++C+ H F R D++ + A
Sbjct: 238 FFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCV-EHHTFFRLTSTDTIPKSKFLALGS 296
Query: 285 EEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAE 344
+ + + + Q + A +R + + A + A T+
Sbjct: 297 KFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAIT 356
Query: 345 KAQITEEEA-KLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEA 391
+ Q+ E A+K + + + +KA + +E E + EA
Sbjct: 357 QGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEA 404
>gi|30061491 erythrocyte membrane protein band 4.1-like 1 isoform b
[Homo sapiens]
Length = 779
Score = 110 bits (275), Expect = 3e-24
Identities = 72/224 (32%), Positives = 112/224 (50%), Gaps = 16/224 (7%)
Query: 46 KEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 105
+ P F F KFYP + + L ++IT++ LQ++ I+ ++ C LL SYAVQ
Sbjct: 101 RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQ 159
Query: 106 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 165
A+ GDYD H ++++ P + L EERI + +RG EAE+ +
Sbjct: 160 AELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGEAEIHF 211
Query: 166 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 225
L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+ F W +I ISY
Sbjct: 212 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYK 268
Query: 226 DKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 265
F IK + + F+ F R K + ++CI +H F
Sbjct: 269 RSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 312
>gi|30061489 erythrocyte membrane protein band 4.1-like 1 isoform a
[Homo sapiens]
Length = 881
Score = 110 bits (275), Expect = 3e-24
Identities = 72/224 (32%), Positives = 112/224 (50%), Gaps = 16/224 (7%)
Query: 46 KEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQ 105
+ P F F KFYP + + L ++IT++ LQ++ I+ ++ C LL SYAVQ
Sbjct: 163 RSSPWNFAFTVKFYPPDPAQ-LTEDITRYYLCLQLRADIITGRLPCSFVTHALLGSYAVQ 221
Query: 106 AKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEY 165
A+ GDYD H ++++ P + L EERI + +RG EAE+ +
Sbjct: 222 AELGDYDAEEHVGNYVSELRFAPNQTREL--------EERIMELHKTYRGMTPGEAEIHF 273
Query: 166 LKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYS 225
L+ A+ L MYGV+ ++ +G +++LGV A GL IY R+ F W +I ISY
Sbjct: 274 LENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRIN---RFAWPKILKISYK 330
Query: 226 DKEFTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 265
F IK + + F+ F R K + ++CI +H F
Sbjct: 331 RSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFF 374
>gi|87042275 erythrocyte protein band 4.1-like 4 [Homo sapiens]
Length = 686
Score = 109 bits (273), Expect = 6e-24
Identities = 85/336 (25%), Positives = 156/336 (46%), Gaps = 22/336 (6%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P T +F KFY E+ + L +EIT++ FFLQVK+ +L ++ CP + L +YA+Q++
Sbjct: 89 PYTLYFGIKFYAEDPCK-LKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSEL 147
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDYDP H G++++ +P + E EE I + G+ EAE+ YL+
Sbjct: 148 GDYDPYKHTAGYVSEYRFVPDQ--------KEELEEAIERIHKTLMGQIPSEAELNYLRT 199
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ LEMYGV+ + + +E LG+ +G+ +Y + ++ + W I + + + +
Sbjct: 200 AKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVG---KYFWPRITKVHFKETQ 256
Query: 229 FTIKPLDKKID--VFKFNSSKLRVNKLILQLCIGNHDLF-MRRRKADSLEVQQMKAQARE 285
F ++ L K + F F + K + + + +H F M +++SL + K +
Sbjct: 257 FELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIR 316
Query: 286 EKAR------KQMERQRLAREKQMREEAERTRDE-LERRLLQMKEEATMANEALMRSEET 338
K R QM R + + + R+R + +R+ Q + + + + + E
Sbjct: 317 YKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAESNSISRITANMEN 376
Query: 339 ADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATA 374
+ I K + E + QR K+ A
Sbjct: 377 GENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHA 412
>gi|32490572 erythrocyte membrane protein band 4.1-like 3 [Homo
sapiens]
Length = 1087
Score = 106 bits (264), Expect = 6e-23
Identities = 67/218 (30%), Positives = 108/218 (49%), Gaps = 16/218 (7%)
Query: 52 FHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDY 111
F F KFYP + + L ++IT++ LQ++ I+ ++ C LL SY VQ++ GDY
Sbjct: 182 FSFNVKFYPPDPAQ-LSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY 240
Query: 112 DPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQD 171
DP ++++ P L E+++ + HRG EAEM +L+ A+
Sbjct: 241 DPDECGSDYISEFRFAPNHTKEL--------EDKVIELHKSHRGMTPAEAEMHFLENAKK 292
Query: 172 LEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTI 231
L MYGV+ ++ +G E++LGV A GL IY R+ F W ++ ISY F I
Sbjct: 293 LSMYGVDLHHAKDSEGVEIMLGVCASGLLIYRDRLRIN---RFAWPKVLKISYKRNNFYI 349
Query: 232 KPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 265
K + + F+ F R K + ++C+ +H F
Sbjct: 350 KIRPGEFEQFESTIGFKLPNHRAAKRLWKVCVEHHTFF 387
>gi|207113199 erythrocyte membrane protein band 4.1-like 2 isoform b
[Homo sapiens]
Length = 673
Score = 106 bits (264), Expect = 6e-23
Identities = 67/221 (30%), Positives = 112/221 (50%), Gaps = 16/221 (7%)
Query: 49 PVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKY 108
P F F KFYP + + L ++IT++ LQ+++ I ++ C LL SY +QA+
Sbjct: 287 PWLFTFNVKFYPPDPSQ-LTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAEL 345
Query: 109 GDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKI 168
GDYDP H L++ + P + L EE++ + HRG + +A+ ++L+
Sbjct: 346 GDYDPEEHGSIDLSEFQFAPTQTKEL--------EEKVAELHKTHRGLSPAQADSQFLEN 397
Query: 169 AQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKE 228
A+ L MYGV+ ++ +G ++ LGV A GL IY R+ F W +I ISY
Sbjct: 398 AKRLSMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRIN---RFAWPKILKISYKRSN 454
Query: 229 FTIKPLDKKIDVFK----FNSSKLRVNKLILQLCIGNHDLF 265
F IK +++ F+ F R K + ++C+ +H +
Sbjct: 455 FYIKVRPAELEQFESTIGFKLPNHRAAKRLWKVCVEHHTFY 495
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.356
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,043,978
Number of Sequences: 37866
Number of extensions: 884783
Number of successful extensions: 20805
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 612
Number of HSP's successfully gapped in prelim test: 1065
Number of HSP's that attempted gapping in prelim test: 7338
Number of HSP's gapped (non-prelim): 7287
length of query: 548
length of database: 18,247,518
effective HSP length: 107
effective length of query: 441
effective length of database: 14,195,856
effective search space: 6260372496
effective search space used: 6260372496
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.