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Search of human proteins with 32490559
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
(713 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|32490559 low density lipoprotein receptor-related protein 10 ... 1493 0.0
gi|167555125 low density lipoprotein receptor-related protein 3 ... 448 e-126
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 379 e-105
gi|208973262 low density lipoprotein-related protein 12 isoform ... 378 e-104
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 101 3e-21
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 91 4e-18
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 91 4e-18
gi|157384998 low density lipoprotein receptor-related protein 4 ... 87 4e-17
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 87 5e-17
gi|28557796 low density lipoprotein receptor class A domain cont... 87 7e-17
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 86 1e-16
gi|93102379 low density lipoprotein-related protein 1B precursor... 84 5e-16
gi|119709832 low density lipoprotein receptor-related protein 5 ... 84 6e-16
gi|61744471 low density lipoprotein receptor-related protein 8 i... 79 1e-14
gi|65301119 low density lipoprotein receptor-related protein 8 i... 79 1e-14
gi|4507157 sortilin-related receptor containing LDLR class A rep... 79 1e-14
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 79 2e-14
gi|148727288 low density lipoprotein receptor-related protein 6 ... 78 2e-14
gi|134031945 SCO-spondin [Homo sapiens] 78 2e-14
gi|29244926 corin [Homo sapiens] 77 6e-14
gi|13899255 membrane frizzled-related protein [Homo sapiens] 75 2e-13
gi|11415040 matriptase [Homo sapiens] 72 2e-12
gi|61744467 low density lipoprotein receptor-related protein 8 i... 69 2e-11
gi|66082554 low density lipoprotein receptor-related protein 8 i... 69 2e-11
gi|7706111 8D6 antigen [Homo sapiens] 69 2e-11
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 66 1e-10
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 61 4e-09
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 54 5e-07
gi|194363725 SWI/SNF-related matrix-associated actin-dependent r... 52 1e-06
gi|239749482 PREDICTED: hypothetical protein [Homo sapiens] 50 6e-06
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 1493 bits (3866), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWL 60
MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWL
Sbjct: 1 MLLATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWL 60
Query: 61 ILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAG 120
ILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAG
Sbjct: 61 ILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAG 120
Query: 121 ARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP 180
ARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP
Sbjct: 121 ARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP 180
Query: 181 GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALD 240
GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALD
Sbjct: 181 GLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALD 240
Query: 241 LGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA 300
LGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA
Sbjct: 241 LGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA 300
Query: 301 TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH 360
TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH
Sbjct: 301 TYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH 360
Query: 361 FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG 420
FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG
Sbjct: 361 FPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG 420
Query: 421 QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPL 480
QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPL
Sbjct: 421 QPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPL 480
Query: 481 SRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG 540
SRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG
Sbjct: 481 SRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGG 540
Query: 541 GPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAR 600
GPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAR
Sbjct: 541 GPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAPLEALDGGTGPAR 600
Query: 601 EGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRG 660
EGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRG
Sbjct: 601 EGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEAPGPLPSLPLEPSLLSGVVQALRG 660
Query: 661 RLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT 713
RLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT
Sbjct: 661 RLLPSLGPPGPTRSPPGPHTAVLALEDEDDVLLVPLAEPGVWVAEAEDEPLLT 713
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 448 bits (1152), Expect = e-126
Identities = 287/741 (38%), Positives = 370/741 (49%), Gaps = 87/741 (11%)
Query: 27 ACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLA----CGS 82
AC E +G + P + NC+W I G + +TI F+ + C
Sbjct: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
Query: 83 ERLTL---RSPLQPLISLCEAPPSPLQLPG-GNVTITYSYAGARAPMGQGFLLSYSQDWL 138
+ L L P Q LC + P + +V I + + + QGF LSY + L
Sbjct: 102 DWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKL 161
Query: 139 ---MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS---SDPFPGLTPR------- 185
C +EF+C N +C+ +C+ VD CGDGSDE CS S+P L P
Sbjct: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSG 221
Query: 186 -------PV-------------------PSLPCNVTLEDFYGVFSSPGYTHLASVSHPQS 219
PV P L C L FYG F+SP A
Sbjct: 222 ARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASPDLFGAARGPSDLH 281
Query: 220 CHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETL 279
C WL+D D RR+ ++ L LG+ D V VY+G G RLL++L++ SN + V++E
Sbjct: 282 CTWLVDTQDSRRVLLQLE-LRLGYDDYVQVYEGLGE-RGDRLLQTLSYRSNHRPVSLEAA 339
Query: 280 SGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCD 339
G+ V+YH A S G GFNATY V+GYCLPW++PCG S G + C+SE QRCD
Sbjct: 340 QGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCFSEPQRCD 399
Query: 340 GSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHC 399
G W CA G DE+ CP CPP +PC G+ CY PADRCN Q C DGADE+ C C
Sbjct: 400 GWWHCASGRDEQGCPACPPDQYPC----EGGSGLCYTPADRCNNQKSCPDGADEKNCFSC 455
Query: 400 QPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIA 459
QPG F C C++ETW CDGQ DC DGSDE C +PRKVITAA+IGSLVCGLLLVIA
Sbjct: 456 QPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVCGLLLVIA 515
Query: 460 LGCTCKLYAIRTQEYSIF-APLSRMEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPND 518
LGC KLY++RTQEY F ++R+EAE V+++APPSYGQLIAQG IPPVEDFP + +
Sbjct: 516 LGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQ 575
Query: 519 NSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEA 578
SVL NLR+ ++ RQ G RR+ GRL RL R R PR P +
Sbjct: 576 ASVLQNLRTAMR--RQMRRHASRRGPSRRRLGRLWNRLFHRPR----APRGQIPLLTAAR 629
Query: 579 RSQVTPSAAPLEALDGGT----GPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTV 634
SQ L+ G P + G+ G++ P P +AP S P P+ +
Sbjct: 630 PSQTVLGDGFLQPAPGAAPDPPAPLMDTGSTRAA-GDRPPSAPGRAPEVGPSGPPLPSGL 688
Query: 635 -----------------PEAPGPLPS-LPLEPSLLSG---VVQALRGRLLP-SLGPPGPT 672
P GP P+ P EP V L P S P G
Sbjct: 689 RDPECRPVDKDRKVCREPLVDGPAPADAPREPCSAQDPHPQVSTASSTLGPHSPEPLGVC 748
Query: 673 RSPPGPHTAVLALEDEDDVLL 693
R+PP P + +L D++ +L+
Sbjct: 749 RNPPPPCSPMLEASDDEALLV 769
Score = 50.8 bits (120), Expect = 4e-06
Identities = 62/237 (26%), Positives = 94/237 (39%), Gaps = 51/237 (21%)
Query: 187 VPSLP-CNVTLEDFY---GVFSSPGYTHLASVSHPQ--SCHWLLDPHDGRRLAVRFTALD 240
VP+L C+ LE GV SP + +++P +C W + G + + F D
Sbjct: 37 VPALAACSGKLEQHTERRGVIYSPAWP----LNYPPGTNCSWYIQGDRGDMITISFRNFD 92
Query: 241 LGFGDAVHV---YDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQ--AVVSYHTVAWSNG 295
+ + GP P R G A+ +S + + +H+ A S+G
Sbjct: 93 VEESHQCSLDWLLLGPAAPPRQEAFRLC-----GSAIPPAFISARDHVWIFFHSDASSSG 147
Query: 296 R--GFNATYHVRGY-----CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGT 348
+ GF +Y +RG C + C G +C +C+ +C DG+
Sbjct: 148 QAQGFRLSY-IRGKLGQASCQADEFRCDNG-----------KCLPGPWQCNTVDECGDGS 195
Query: 349 DEEDC-------PG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRC 396
DE +C PG CP G FPC A +T C RC+ C DG+DE C
Sbjct: 196 DEGNCSAPASEPPGSLCPGGTFPCSGA---RSTRCLPVERRCDGLQDCGDGSDEAGC 249
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 379 bits (972), Expect = e-105
Identities = 271/794 (34%), Positives = 372/794 (46%), Gaps = 127/794 (15%)
Query: 4 ATLLLLLLG----GALA-HPDRIIFP--NHACEDPPAVLLEVQGTLQRPLVRDSRTSPAN 56
A LLL L G GALA H + + + AC + P + G + P + N
Sbjct: 16 ALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKIN 75
Query: 57 CTWLILGSKEQTVTIRFQKLHLA----CGSERLTLRS--PLQPLISLCEAPPSPLQLPGG 110
C+W I + + +TI FQ + C + LT+ + ++ + P P
Sbjct: 76 CSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQD 135
Query: 111 NVTITYSYAGARAPMGQGFLLSY---SQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGD 167
++ I + + +GF L+Y + C ++F+C N +C+ +C+ +D CGD
Sbjct: 136 HIWIRFHSDDNISR--KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGD 193
Query: 168 GSDEAGCSSDPFPGLTPRPVPS-----------------LP------------------- 191
SDE C+ + P P LP
Sbjct: 194 SSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID 253
Query: 192 -----CNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDL---GF 243
C L+ FYG F+SP Y +C WL+D D R++ +RFT L G+
Sbjct: 254 CDVPTCGQWLKYFYGTFNSPNYPDFYPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGY 311
Query: 244 GDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYH 303
GD V +YDG +LLR LT F + +TV + SGQ V + + RGFNATY
Sbjct: 312 GDYVKIYDGL-EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 370
Query: 304 VRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPC 363
V G+CLPW+ PCG G CY+E QRCDG W C +G DE +C C FPC
Sbjct: 371 VDGFCLPWEIPCGGNWG----------CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
Query: 364 GAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPD 423
G CY +DRCNYQ C +G+DE+ C CQPGNF C++ +CV+E+WVCD Q D
Sbjct: 421 SRNGV-----CYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDD 475
Query: 424 CADGSDEWDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIF-APLSR 482
C DGSDE +C ++P +VITAAVIGSL+CGLLLVIALGCTCKLY++R E F LSR
Sbjct: 476 CGDGSDEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSR 535
Query: 483 MEAEIVQQQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGP 542
+EAE+++++APPSYGQLIAQG IPPVEDFP +PN SVL NLR ++ + G
Sbjct: 536 VEAELLRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVR------SQLGFT 589
Query: 543 GARRRQRGRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAP-------------L 589
R GR + R+ + + + A S +V PS +
Sbjct: 590 SVRLPMAGR-SSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLF 648
Query: 590 EALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPS---------ASTSPAPT-------- 632
T E + G G A PLP K P + AS+S T
Sbjct: 649 SVESDDTDTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNG 708
Query: 633 ---TVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGP----HTAVLAL 685
T E P P+ S LS + Q LR + +LG P V
Sbjct: 709 RDVTSVEPPSVSPARHQLTSALSRMTQGLRW-VRFTLGRSSSLSQNQSPLRQLDNGVSGR 767
Query: 686 EDEDDV-LLVPLAE 698
ED+DDV +L+P+++
Sbjct: 768 EDDDDVEMLIPISD 781
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 378 bits (970), Expect = e-104
Identities = 266/787 (33%), Positives = 366/787 (46%), Gaps = 131/787 (16%)
Query: 4 ATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILG 63
+ LLLL L G +AC + P + G + P + NC+W I
Sbjct: 15 SALLLLFLAGV-----------YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA 63
Query: 64 SKEQTVTIRFQKLHLA----CGSERLTLRS--PLQPLISLCEAPPSPLQLPGGNVTITYS 117
+ + +TI FQ + C + LT+ + ++ + P P ++ I +
Sbjct: 64 NPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFH 123
Query: 118 YAGARAPMGQGFLLSY---SQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
+ +GF L+Y + C ++F+C N +C+ +C+ +D CGD SDE C
Sbjct: 124 SDDNISR--KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEIC 181
Query: 175 SSDPFPGLTPRPVPS-----------------LP------------------------CN 193
+ + P P LP C
Sbjct: 182 AKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 241
Query: 194 VTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDL---GFGDAVHVY 250
L+ FYG F+SP Y +C WL+D D R++ +RFT L G+GD V +Y
Sbjct: 242 QWLKYFYGTFNSPNYPDFYPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 299
Query: 251 DGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP 310
DG +LLR LT F + +TV + SGQ V + + RGFNATY V G+CLP
Sbjct: 300 DGL-EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLP 358
Query: 311 WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSG 370
W+ PCG G CY+E QRCDG W C +G DE +C C FPC G
Sbjct: 359 WEIPCGGNWG----------CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGV-- 406
Query: 371 ATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
CY +DRCNYQ C +G+DE+ C CQPGNF C++ +CV+E+WVCD Q DC DGSDE
Sbjct: 407 ---CYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
Query: 431 WDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIF-APLSRMEAEIVQ 489
+C ++P +VITAAVIGSL+CGLLLVIALGCTCKLY++R E F LSR+EAE+++
Sbjct: 464 ENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLR 523
Query: 490 QQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQR 549
++APPSYGQLIAQG IPPVEDFP +PN SVL NLR ++ + G R
Sbjct: 524 REAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVR------SQLGFTSVRLPMA 577
Query: 550 GRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAP-------------LEALDGGT 596
GR + R+ + + + A S +V PS + T
Sbjct: 578 GR-SSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDT 636
Query: 597 GPAREGGAVGGQDGEQAPPLPIKAPLPS---------ASTSPAPT-----------TVPE 636
E + G G A PLP K P + AS+S T T E
Sbjct: 637 DTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVE 696
Query: 637 APGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGP----HTAVLALEDEDDV- 691
P P+ S LS + Q LR + +LG P V ED+DDV
Sbjct: 697 PPSVSPARHQLTSALSRMTQGLRW-VRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVE 755
Query: 692 LLVPLAE 698
+L+P+++
Sbjct: 756 MLIPISD 762
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 101 bits (251), Expect = 3e-21
Identities = 90/306 (29%), Positives = 122/306 (39%), Gaps = 46/306 (15%)
Query: 139 MCLQEEFQCLN-HRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLE 197
+CL +F+C N +RC+ + RC+G D CGDG DE C P +T P C++T
Sbjct: 3412 VCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDC-----PEVTCAP-NQFQCSITKR 3465
Query: 198 DFYGVFSSPGYTHLASVS-HPQSCHWLLDPHD-------GRRLAVRFTALDLGFGDAVHV 249
V+ S P +C + D GR + R+ G D
Sbjct: 3466 CIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCD--GEDDCG-- 3521
Query: 250 YDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCL 309
DG P+ R+ + + + V + N G N+ C
Sbjct: 3522 -DGSDEPKEECDERTCEPYQ------FRCKNNRCVPGRWQCDYDNDCGDNSDEES---CT 3571
Query: 310 PWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC-PGCPPGHFPCGAAGT 368
P RPC S G RC + +CDG DCADG+DE+DC P C F C +
Sbjct: 3572 P--RPCS-ESEFSCANG---RCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQCKSGH- 3624
Query: 369 SGATACYLPADRCNYQTFCADGADERRC----RHCQPGNFRCRDEKCVYETWVCDGQPDC 424
C RC+ C DG+DE C R C F+C + C W CDG+ DC
Sbjct: 3625 -----CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDC 3679
Query: 425 ADGSDE 430
D SDE
Sbjct: 3680 GDNSDE 3685
Score = 88.6 bits (218), Expect = 2e-17
Identities = 40/106 (37%), Positives = 56/106 (52%), Gaps = 12/106 (11%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG-----CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
CY+ + CDG+ DC D +DE DCPG CP +F C + C + C+ +
Sbjct: 2666 CYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSG------RCIPMSWTCDKED 2719
Query: 386 FCADGADERRC-RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C G DE C + C F C++ +C+ + W+CDG DC DGSDE
Sbjct: 2720 DCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE 2765
Score = 85.5 bits (210), Expect = 2e-16
Identities = 44/111 (39%), Positives = 54/111 (48%), Gaps = 12/111 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDE--EDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC +CDG DC DG+DE E+C C P F C C +C+Y
Sbjct: 3506 RCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKN------NRCVPGRWQCDYDN 3559
Query: 386 FCADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C D +DE C R C F C + +C+ W CDG DCADGSDE DC+
Sbjct: 3560 DCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCT 3610
Score = 81.3 bits (199), Expect = 3e-15
Identities = 43/105 (40%), Positives = 51/105 (48%), Gaps = 10/105 (9%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
C + A CDG DC D +DE +C C P F C + C RCN Q C
Sbjct: 3386 CTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKC-----TNTNRCIPGIFRCNGQDNCG 3440
Query: 389 DGADERRCRH--CQPGNFRCR-DEKCVYETWVCDGQPDCADGSDE 430
DG DER C C P F+C ++C+ WVCD DC DGSDE
Sbjct: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDE 3485
Score = 77.0 bits (188), Expect = 6e-14
Identities = 47/116 (40%), Positives = 58/116 (50%), Gaps = 15/116 (12%)
Query: 330 RCYSEAQRCDGSWDCADGTDEE-DCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
RC S+ CDGS DC DG+DE C G C P F C G C C+
Sbjct: 2745 RCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC-----PGTHVCVPERWLCDGDKD 2799
Query: 387 CADGADER---RCRH---CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEW-DCSY 435
CADGADE C + C F C++ +C+ + +VCD DCADGSDE +C Y
Sbjct: 2800 CADGADESIAAGCLYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEY 2855
Score = 76.6 bits (187), Expect = 7e-14
Identities = 87/316 (27%), Positives = 122/316 (38%), Gaps = 57/316 (18%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-------CSSDPFPGLTPRPVP-SLP 191
C + F+C N+RC+ CDG + CG+ DE+ C + F + R +P S
Sbjct: 895 CPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWT 954
Query: 192 CNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLD--PHDGRRLAVRFTA-LDLGFGDAVH 248
C+ L+D G S AS ++P +C L ++GR + + + D GD
Sbjct: 955 CD--LDDDCGDRSDES----ASCAYP-TCFPLTQFTCNNGRCININWRCDNDNDCGDNS- 1006
Query: 249 VYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRG----------F 298
D G S S T F SG+ + + T N G
Sbjct: 1007 --DEAGCSHSC----SSTQFKCN--------SGRCIPEHWTCDGDNDCGDYSDETHANCT 1052
Query: 299 NATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPP 358
N G C + C L +GL C RCDG DC D +DE+ C G
Sbjct: 1053 NQATRPPGGCHTDEFQCRL-------DGL---CIPLRWRCDGDTDCMDSSDEKSCEGVTH 1102
Query: 359 GHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRH--CQPGNFRCRDEK--CVYE 414
P G + C A C+ C D +DE C C+P + C + C+
Sbjct: 1103 VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPP 1162
Query: 415 TWVCDGQPDCADGSDE 430
+CDG DC DGSDE
Sbjct: 1163 DKLCDGNDDCGDGSDE 1178
Score = 73.6 bits (179), Expect = 6e-13
Identities = 76/301 (25%), Positives = 108/301 (35%), Gaps = 25/301 (8%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS---DPFPGLTPRPVPSLPCNVTL 196
C EF+C + C+ RC+ C D SDE CS+ + L + V PC T
Sbjct: 2605 CGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTS 2664
Query: 197 EDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPP 256
+ + G S + C + P R + + A G + +
Sbjct: 2665 LCYAPSWVCDGANDCGDYSDERDCPGVKRP----RCPLNYFACP--SGRCIPMSWTCDKE 2718
Query: 257 ESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSN---GRGFNATYHVRGYCLPWDR 313
+ TH + + +S + + G G + H G +
Sbjct: 2719 DDCEHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEG------K 2772
Query: 314 PCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATA 373
CG S G + C E CDG DCADG DE GC
Sbjct: 2773 TCGPSSFSCPGTHV---CVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQ 2829
Query: 374 CYLPADRCNYQTFCADGADER-RCRH--CQPGNFRCRDEKCV-YETWVCDGQPDCADGSD 429
C C++ CADG+DE C + C P FRC + +C+ W CDG+ DC D SD
Sbjct: 2830 CIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSD 2889
Query: 430 E 430
E
Sbjct: 2890 E 2890
Score = 73.2 bits (178), Expect = 8e-13
Identities = 38/107 (35%), Positives = 47/107 (43%), Gaps = 9/107 (8%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFC 387
RC +CD DC D +DEE C C F C C +C+ C
Sbjct: 3547 RCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG------RCIAGRWKCDGDHDC 3600
Query: 388 ADGADERRCR-HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
ADG+DE+ C C F+C+ C+ W CD DC DGSDE C
Sbjct: 3601 ADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC 3647
Score = 72.8 bits (177), Expect = 1e-12
Identities = 47/139 (33%), Positives = 59/139 (42%), Gaps = 21/139 (15%)
Query: 330 RCYSEAQRCDGSWDCADGTDEE--DCP--------GCPPGHFPCGAAGTSGATACYLPAD 379
RC E CDG DC D +DE +C GC F C G C
Sbjct: 1026 RCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGL-----CIPLRW 1080
Query: 380 RCNYQTFCADGADERRCRH----CQPG-NFRCRDE-KCVYETWVCDGQPDCADGSDEWDC 433
RC+ T C D +DE+ C C P F C+D +C+ + WVCDG DC D SDE +C
Sbjct: 1081 RCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
Query: 434 SYVLPRKVITAAVIGSLVC 452
+ R + VC
Sbjct: 1141 ESLACRPPSHPCANNTSVC 1159
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/114 (35%), Positives = 54/114 (47%), Gaps = 12/114 (10%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEE-DCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
++C +CD DC D +DE DCP C PG F C C PA C+
Sbjct: 3344 DKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTG------ICTNPAFICDGDN 3397
Query: 386 FCADGADERRC--RHCQPGNFRCRD-EKCVYETWVCDGQPDCADGSDEWDCSYV 436
C D +DE C C P F+C + +C+ + C+GQ +C DG DE DC V
Sbjct: 3398 DCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEV 3451
Score = 71.6 bits (174), Expect = 2e-12
Identities = 41/113 (36%), Positives = 54/113 (47%), Gaps = 12/113 (10%)
Query: 329 ERCYSEAQRCDGSWDCADGTDE-EDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
+RC CD DC DG+DE +C C F C +G C +C+ +
Sbjct: 3464 KRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSG-----RCIPARWKCDGED 3518
Query: 386 FCADGADE--RRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG+DE C R C+P FRC++ +CV W CD DC D SDE C+
Sbjct: 3519 DCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCT 3571
Score = 70.9 bits (172), Expect = 4e-12
Identities = 46/136 (33%), Positives = 64/136 (47%), Gaps = 21/136 (15%)
Query: 331 CYSEAQRCDGSWDCADGTDE--EDCPG--CPPGH-FPCGAAGTSGATACYLPADRCNYQT 385
C A +CDG DC D +DE E+C CPP F C C +C+
Sbjct: 3666 CKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRC-----KNDRVCLWIGRQCDGTD 3720
Query: 386 FCADGADERRCR-------HCQPGN-FRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVL 437
C DG DE C HC+ F CR+++C+ + C+ DC DGSDE DCS +
Sbjct: 3721 NCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCS-ID 3779
Query: 438 PRKVITAAVIGSLVCG 453
P+ +T+ + +CG
Sbjct: 3780 PK--LTSCATNASICG 3793
Score = 67.8 bits (164), Expect = 3e-11
Identities = 43/118 (36%), Positives = 51/118 (43%), Gaps = 20/118 (16%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFC 387
RC S C+G+ DC DG+DE C C G F C GT C + RCN C
Sbjct: 2577 RCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC-RDGT-----CIGNSSRCNQFVDC 2630
Query: 388 ADGADERRCRHCQPGNF-----------RC-RDEKCVYETWVCDGQPDCADGSDEWDC 433
D +DE C ++ C R C +WVCDG DC D SDE DC
Sbjct: 2631 EDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDC 2688
Score = 67.4 bits (163), Expect = 4e-11
Identities = 39/133 (29%), Positives = 54/133 (40%), Gaps = 12/133 (9%)
Query: 314 PCG-LGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCP-PGHFPCGAAGT--- 368
PC G+G C + RC+ DC D +DE +C +F G G
Sbjct: 2599 PCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQ 2658
Query: 369 --SGATACYLPADRCNYQTFCADGADERRCR-----HCQPGNFRCRDEKCVYETWVCDGQ 421
+ CY P+ C+ C D +DER C C F C +C+ +W CD +
Sbjct: 2659 PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKE 2718
Query: 422 PDCADGSDEWDCS 434
DC G DE C+
Sbjct: 2719 DDCEHGEDETHCN 2731
Score = 63.5 bits (153), Expect = 6e-10
Identities = 37/114 (32%), Positives = 48/114 (42%), Gaps = 14/114 (12%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC CDG DC + DE + CPP F C + C + C+
Sbjct: 906 RCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASG------RCIPISWTCDLDD 959
Query: 386 FCADGADERR-CRH--CQP-GNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSY 435
C D +DE C + C P F C + +C+ W CD DC D SDE CS+
Sbjct: 960 DCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSH 1013
Score = 62.4 bits (150), Expect = 1e-09
Identities = 37/115 (32%), Positives = 45/115 (39%), Gaps = 15/115 (13%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC----PGCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC E +CDG DC D +DE CP F C C C+
Sbjct: 865 RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCEN------NRCIPNRWLCDGDN 918
Query: 386 FCADGADERRC----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE-WDCSY 435
C + DE R C P F C +C+ +W CD DC D SDE C+Y
Sbjct: 919 DCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAY 973
Score = 60.1 bits (144), Expect = 7e-09
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 15/115 (13%)
Query: 330 RCYSEAQRCDGSWDCADGTDEE---DCPGCPPGHFPCGAAGT--------SGATACYLPA 378
+C + CD DCADG+DE + P C P F C G C+ +
Sbjct: 2829 QCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQS 2888
Query: 379 DRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
D C + E +C F C +CV E +C+GQ DC D SDE C
Sbjct: 2889 DEAPKNPHCT--SQEHKCN--ASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC 2939
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/110 (32%), Positives = 46/110 (41%), Gaps = 12/110 (10%)
Query: 331 CYSEAQRCDGSWDCADGTDEE----DCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C + + CDG C D +DE+ + C C C CN
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG------RCVSNMLWCNGADD 2590
Query: 387 CADGADERRCRH--CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG+DE C C G FRCRD C+ + C+ DC D SDE +CS
Sbjct: 2591 CGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
Score = 51.2 bits (121), Expect = 3e-06
Identities = 18/32 (56%), Positives = 21/32 (65%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
CQPG F C + +C+ E W CDG DC D SDE
Sbjct: 854 CQPGEFACANSRCIQERWKCDGDNDCLDNSDE 885
Score = 50.4 bits (119), Expect = 6e-06
Identities = 21/37 (56%), Positives = 26/37 (70%)
Query: 142 QEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
++EF C N RC+S+ RC+ D CGDGSDE CS DP
Sbjct: 3744 KKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDP 3780
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/142 (30%), Positives = 52/142 (36%), Gaps = 26/142 (18%)
Query: 331 CYSEAQRCDGSWDCADGTDE--EDCP-----GCPPGHFPCGAAGTSGATACYLPADRCNY 383
C S+ RCDG DC DG+DE E CP C P C G C + CN
Sbjct: 40 CISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-----LGTELCVPMSRLCNG 94
Query: 384 QTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDC---------ADG---SDEW 431
C DG+DE HC+ C C + P C ADG D
Sbjct: 95 VQDCMDGSDEG--PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFD 152
Query: 432 DCSYVLPRKVITAAVIGSLVCG 453
+CS + GS +CG
Sbjct: 153 ECSVYGTCSQLCTNTDGSFICG 174
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/77 (33%), Positives = 35/77 (45%), Gaps = 5/77 (6%)
Query: 358 PGHFPCGAAGTSGATACYLP---ADRCNYQTFCADGADERRC-RHCQPGNFRCRDEKCVY 413
P H PC + C L +C T G+D R C +C F C+++KC+
Sbjct: 3290 PNH-PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVCKNDKCIP 3348
Query: 414 ETWVCDGQPDCADGSDE 430
W CD + DC D SDE
Sbjct: 3349 FWWKCDTEDDCGDHSDE 3365
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/33 (54%), Positives = 22/33 (66%), Gaps = 1/33 (3%)
Query: 399 CQPGNFRCRDE-KCVYETWVCDGQPDCADGSDE 430
C P F CRD+ C+ + W CDG+ DC DGSDE
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE 59
Score = 43.9 bits (102), Expect = 5e-04
Identities = 19/36 (52%), Positives = 23/36 (63%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
C + QC N RCVS + C+G D CGDGSDE C+
Sbjct: 2566 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCN 2601
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/41 (43%), Positives = 23/41 (56%)
Query: 134 SQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
SQ+ +F C + RCV+ C+G D CGD SDE GC
Sbjct: 2899 SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC 2939
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/35 (51%), Positives = 24/35 (68%), Gaps = 1/35 (2%)
Query: 138 LMCLQEEFQCLNH-RCVSAVQRCDGVDACGDGSDE 171
+ C +EF+C + RC+ A +CDG D CGDGSDE
Sbjct: 3492 MTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 40.4 bits (93), Expect = 0.006
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 7/57 (12%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEA-------GCSSDPFPGLTPRPVPS 189
C EF C N RC+ +CDG + C D SDEA C SD F R +P+
Sbjct: 854 CQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPN 910
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/85 (32%), Positives = 36/85 (42%), Gaps = 17/85 (20%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFC- 387
+RC S + RC+ DC DG+DEEDC P T+C A C + C
Sbjct: 3752 QRCLSSSLRCNMFDDCGDGSDEEDCSIDPK------------LTSCATNASICGDEARCV 3799
Query: 388 -ADGADERRCR---HCQPGNFRCRD 408
+ A CR H PG C+D
Sbjct: 3800 RTEKAAYCACRSGFHTVPGQPGCQD 3824
Score = 38.5 bits (88), Expect = 0.022
Identities = 16/31 (51%), Positives = 21/31 (67%), Gaps = 1/31 (3%)
Query: 145 FQCLNHR-CVSAVQRCDGVDACGDGSDEAGC 174
F+C N R C+ ++CDG D CGDG+DE C
Sbjct: 3701 FRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731
Score = 37.7 bits (86), Expect = 0.037
Identities = 15/30 (50%), Positives = 19/30 (63%)
Query: 142 QEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
Q+EF+C N C++ CDGV C D SDE
Sbjct: 2527 QDEFECANGECINFSLTCDGVPHCKDKSDE 2556
Score = 37.7 bits (86), Expect = 0.037
Identities = 18/34 (52%), Positives = 22/34 (64%), Gaps = 1/34 (2%)
Query: 140 CLQEEFQCLNHRCVSAVQ-RCDGVDACGDGSDEA 172
C EF+C N RC+S+ Q CDG + C D SDEA
Sbjct: 2858 CGPSEFRCANGRCLSSRQWECDGENDCHDQSDEA 2891
Score = 36.2 bits (82), Expect = 0.11
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C +F C N +C+ +CD D CGD SDE
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE 3365
Score = 35.4 bits (80), Expect = 0.18
Identities = 15/35 (42%), Positives = 18/35 (51%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +FQC C + CDG + C D SDEA C
Sbjct: 3374 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3408
Score = 34.3 bits (77), Expect = 0.41
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Query: 140 CLQEEFQCLNH-RCVSAVQRCDGVDACGDGSDEA 172
C ++F C + C+S RCDG C DGSDEA
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEA 60
Score = 33.5 bits (75), Expect = 0.70
Identities = 16/36 (44%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 138 LMCLQEEFQCLNHR--CVSAVQRCDGVDACGDGSDE 171
L C C N+ C+ + CDG D CGDGSDE
Sbjct: 1143 LACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDE 1178
Score = 33.5 bits (75), Expect = 0.70
Identities = 23/80 (28%), Positives = 32/80 (40%), Gaps = 14/80 (17%)
Query: 102 PSPLQLPGGNVTITYSYA---------GARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRC 152
PS PG +V + + GA + G L + + C EF C N +C
Sbjct: 2776 PSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST-----CDDREFMCQNRQC 2830
Query: 153 VSAVQRCDGVDACGDGSDEA 172
+ CD C DGSDE+
Sbjct: 2831 IPKHFVCDHDRDCADGSDES 2850
Score = 32.3 bits (72), Expect = 1.6
Identities = 12/27 (44%), Positives = 16/27 (59%)
Query: 404 FRCRDEKCVYETWVCDGQPDCADGSDE 430
F C + +C+ + CDG P C D SDE
Sbjct: 2530 FECANGECINFSLTCDGVPHCKDKSDE 2556
Score = 30.8 bits (68), Expect = 4.6
Identities = 15/33 (45%), Positives = 17/33 (51%), Gaps = 1/33 (3%)
Query: 140 CLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDE 171
C E CL CV + C+GV C DGSDE
Sbjct: 72 CQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 90.9 bits (224), Expect = 4e-18
Identities = 87/319 (27%), Positives = 120/319 (37%), Gaps = 58/319 (18%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-----CSSDPFPGLTPRPVPSL-PCN 193
C +FQC N RC++ + +CDG + C DGSDE C+ F + VPS C+
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92
Query: 194 VTLEDFYGVFSSPGYTHLASVS-HPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDG 252
+ G SP H+ + H SC H + + V + DG
Sbjct: 93 GDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCIPVSWRC------------DG 136
Query: 253 PGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWD 312
+S E G S S+GR + + G
Sbjct: 137 ENDCDSGE---------------DEENCGNITCSPDEFTCSSGRCISRNFVCNG-----Q 176
Query: 313 RPCGLGS----------GLGAGEGLGERCYSEAQRCDGSWDCADGTDE--EDCPGCPPGH 360
C GS G + C + CD DC+D +DE E C P H
Sbjct: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
Query: 361 FPCGAAGTS-GATACYLPADRCNYQTFCADGADERRC--RHCQPGNFRCRDEKCVYETWV 417
C A+ G+ C RC+ C DG+DE C R C+P F C D C++ +
Sbjct: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 418 CDGQPDCADGSDEWDCSYV 436
C+G DC DGSDE +C V
Sbjct: 297 CNGIRDCVDGSDEVNCKNV 315
Score = 79.7 bits (195), Expect = 9e-15
Identities = 43/111 (38%), Positives = 58/111 (52%), Gaps = 13/111 (11%)
Query: 326 GLGERCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNY 383
G GE C + RCDG DC DG+DE +CP C P F C +C + +CN
Sbjct: 247 GSGE-CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG------SCIHGSRQCNG 299
Query: 384 QTFCADGADERRCRHCQ----PGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C DG+DE C++ PG F+CR +C+ + VC+ + DC D SDE
Sbjct: 300 IRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/38 (44%), Positives = 23/38 (60%)
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
+ C +EF C + RC+S C+G D C DGSDE C+
Sbjct: 152 ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA 189
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 90.9 bits (224), Expect = 4e-18
Identities = 87/319 (27%), Positives = 120/319 (37%), Gaps = 58/319 (18%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-----CSSDPFPGLTPRPVPSL-PCN 193
C +FQC N RC++ + +CDG + C DGSDE C+ F + VPS C+
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCD 92
Query: 194 VTLEDFYGVFSSPGYTHLASVS-HPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDG 252
+ G SP H+ + H SC H + + V + DG
Sbjct: 93 GDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCIPVSWRC------------DG 136
Query: 253 PGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWD 312
+S E G S S+GR + + G
Sbjct: 137 ENDCDSGE---------------DEENCGNITCSPDEFTCSSGRCISRNFVCNG-----Q 176
Query: 313 RPCGLGS----------GLGAGEGLGERCYSEAQRCDGSWDCADGTDE--EDCPGCPPGH 360
C GS G + C + CD DC+D +DE E C P H
Sbjct: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
Query: 361 FPCGAAGTS-GATACYLPADRCNYQTFCADGADERRC--RHCQPGNFRCRDEKCVYETWV 417
C A+ G+ C RC+ C DG+DE C R C+P F C D C++ +
Sbjct: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
Query: 418 CDGQPDCADGSDEWDCSYV 436
C+G DC DGSDE +C V
Sbjct: 297 CNGIRDCVDGSDEVNCKNV 315
Score = 79.7 bits (195), Expect = 9e-15
Identities = 43/111 (38%), Positives = 58/111 (52%), Gaps = 13/111 (11%)
Query: 326 GLGERCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNY 383
G GE C + RCDG DC DG+DE +CP C P F C +C + +CN
Sbjct: 247 GSGE-CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG------SCIHGSRQCNG 299
Query: 384 QTFCADGADERRCRHCQ----PGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C DG+DE C++ PG F+CR +C+ + VC+ + DC D SDE
Sbjct: 300 IRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 42.4 bits (98), Expect = 0.002
Identities = 17/38 (44%), Positives = 23/38 (60%)
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
+ C +EF C + RC+S C+G D C DGSDE C+
Sbjct: 152 ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA 189
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 87.4 bits (215), Expect = 4e-17
Identities = 48/134 (35%), Positives = 58/134 (43%), Gaps = 20/134 (14%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGA 365
C P D C G +C + CDG DC D +DE+DCP C FPC
Sbjct: 71 CSPLDFHCDNG-----------KCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQN 119
Query: 366 AGTSGATACYLPADRCNYQTFCADGADER-RCRHCQPGNFRCRDEKCVYETWVCDGQPDC 424
C C+ C D +DE+ R C FRC D C+ E W CDG DC
Sbjct: 120 G------YCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDC 173
Query: 425 ADGSDEWDCSYVLP 438
DGSDE +C +P
Sbjct: 174 KDGSDEENCPSAVP 187
Score = 84.3 bits (207), Expect = 3e-16
Identities = 43/109 (39%), Positives = 52/109 (47%), Gaps = 11/109 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG---CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
RC + CDG DC D +DE DC C G F C + C RC+
Sbjct: 202 RCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSG------LCINAGWRCDGDAD 255
Query: 387 CADGADERRCRH--CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C D +DER C C FRC +CV +W CDG+ DCAD SDE +C
Sbjct: 256 CDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Score = 81.3 bits (199), Expect = 3e-15
Identities = 42/108 (38%), Positives = 52/108 (48%), Gaps = 5/108 (4%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATA-CYLPADRCNYQTFCAD 389
C +E CDG DC DG+DEE+CP P PC A C L C+ C D
Sbjct: 160 CIAEHWYCDGDTDCKDGSDEENCPSAVPAP-PCNLEEFQCAYGRCILDIYHCDGDDDCGD 218
Query: 390 GADERRC---RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
+DE C + C+ G F C C+ W CDG DC D SDE +C+
Sbjct: 219 WSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCT 266
Score = 75.1 bits (183), Expect = 2e-13
Identities = 43/121 (35%), Positives = 54/121 (44%), Gaps = 11/121 (9%)
Query: 315 CGLGSGLGAGEGLGE-RCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPCGAAGTSGA 371
CG A LGE C +CDG DC D +DE+ C P C P F C
Sbjct: 27 CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNG----- 81
Query: 372 TACYLPADRCNYQTFCADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSD 429
C + C+ C D +DE+ C R C+ F C++ C+ W CDG DC D SD
Sbjct: 82 -KCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSD 140
Query: 430 E 430
E
Sbjct: 141 E 141
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/149 (30%), Positives = 64/149 (42%), Gaps = 19/149 (12%)
Query: 295 GRGFNATYHVRGY--CLPW--DRPCGLGSGLGAGEGLGER--CYSEAQRCDGSWDCADGT 348
GR YH G C W + C +GE + + C + RCDG DC D +
Sbjct: 201 GRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQS 260
Query: 349 DEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRH-----CQP 401
DE +C C F C + C + RC+ + CAD +DE C + C
Sbjct: 261 DERNCTTSMCTAEQFRCHSG------RCVRLSWRCDGEDDCADNSDEENCENTGSPQCAL 314
Query: 402 GNFRCRDEKCVYETWVCDGQPDCADGSDE 430
F C + +C+ + +C+G DC D SDE
Sbjct: 315 DQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Score = 49.7 bits (117), Expect = 9e-06
Identities = 21/37 (56%), Positives = 24/37 (64%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C EEFQC RC+ + CDG D CGD SDE+ CSS
Sbjct: 191 CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSS 227
Score = 48.9 bits (115), Expect = 2e-05
Identities = 73/304 (24%), Positives = 104/304 (34%), Gaps = 51/304 (16%)
Query: 136 DWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVT 195
D C +EF+C + C++ CDG C DGSDE C P VP+ PCN
Sbjct: 144 DMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC---------PSAVPAPPCN-- 192
Query: 196 LEDF---YG-----VFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAV 247
LE+F YG ++ G S C G + ++ G+
Sbjct: 193 LEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCDSGLCINAGWR--- 249
Query: 248 HVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAW-SNGRGFNATYHVRG 306
DG + R+ T S A SG+ V ++W +G A
Sbjct: 250 --CDGDADCDDQSDERNCT-TSMCTAEQFRCHSGRCV----RLSWRCDGEDDCADNSDEE 302
Query: 307 YCLPWDRP-CGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPP--GHFPC 363
C P C L L RC + + C+G DC D +DE C P G C
Sbjct: 303 NCENTGSPQCALDQFL----CWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENC 358
Query: 364 GAAGTSGATACYL--PADRCNYQTFCADGADERRCR---------HCQPGNFRCRDEKCV 412
A C + A +C T D C+ +C G C + +
Sbjct: 359 NVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQG---CTNSEGA 415
Query: 413 YETW 416
++ W
Sbjct: 416 FQCW 419
Score = 40.4 bits (93), Expect = 0.006
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C ++EF C N C+ ++ CDG + CGD SDE
Sbjct: 110 CEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Score = 34.7 bits (78), Expect = 0.32
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 9/58 (15%)
Query: 387 CADG-ADERRCRHCQPGNFRCR-----DEKCVYETWVCDGQPDCADGSDEWDCSYVLP 438
CA G A C C +F C + C+ W CDG DC D SDE C +LP
Sbjct: 15 CAHGLASSPECA-CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGC--ILP 69
Score = 34.7 bits (78), Expect = 0.32
Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 5/46 (10%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-----CSSDPFP 180
C +F C N +C+ CDG + C D SDE C D FP
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP 116
Score = 33.9 bits (76), Expect = 0.54
Identities = 13/23 (56%), Positives = 16/23 (69%)
Query: 152 CVSAVQRCDGVDACGDGSDEAGC 174
C+ A +CDG + CGD SDE GC
Sbjct: 44 CIPAQWQCDGDNDCGDHSDEDGC 66
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 87.0 bits (214), Expect = 5e-17
Identities = 46/128 (35%), Positives = 56/128 (43%), Gaps = 19/128 (14%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGA 365
C D CG G RC + RCDG DC +G+DE+ CP C F C
Sbjct: 68 CKSGDFSCG---------GRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD 118
Query: 366 AGTSGATACYLPADRCNYQTFCADGADERRCR--HCQPGNFRCRDEKCVYETWVCDGQPD 423
C C+ C DG+DE C C P +F+C C+ + W CD PD
Sbjct: 119 G------KCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPD 172
Query: 424 CADGSDEW 431
C DGSDEW
Sbjct: 173 CEDGSDEW 180
Score = 83.2 bits (204), Expect = 8e-16
Identities = 45/110 (40%), Positives = 55/110 (50%), Gaps = 10/110 (9%)
Query: 330 RCYSEAQRCDGSWDCADGTDE--EDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
+C S CDGS +C DG+DE E C C G F CG C RC+ Q
Sbjct: 38 KCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGR----VNRCIPQFWRCDGQV 93
Query: 386 FCADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C +G+DE+ C + C FRC D KC+ +VCD DC DGSDE C
Sbjct: 94 DCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
Score = 79.3 bits (194), Expect = 1e-14
Identities = 42/119 (35%), Positives = 55/119 (46%), Gaps = 20/119 (16%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTFC 387
+C S CD DC DG+DE CP C P F C ++ C C+ C
Sbjct: 120 KCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSS------TCIPQLWACDNDPDC 173
Query: 388 ADGADE--RRCRH----------CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
DG+DE +RCR C F C +C++ +W CDG PDC D SDE +C+
Sbjct: 174 EDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA 232
Score = 63.2 bits (152), Expect = 8e-10
Identities = 37/110 (33%), Positives = 51/110 (46%), Gaps = 12/110 (10%)
Query: 327 LGERCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPCGAAGTSGATACYLPADRCNYQ 384
L C + RCDG DC D +DEE+C C P F C C + +C+ +
Sbjct: 205 LSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGN------CIHGSRQCDRE 258
Query: 385 TFCADGADERRCRH---CQ-PGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C D +DE C + C+ P F+C +C+ VC+ DC D SDE
Sbjct: 259 YDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDE 308
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/111 (33%), Positives = 50/111 (45%), Gaps = 8/111 (7%)
Query: 331 CYSEAQRCDGSWDCADGTDE--EDCPGC---PPGHFPCGAAGTSGATA-CYLPADRCNYQ 384
C + CD DC DG+DE + C G PC A + C + RC+
Sbjct: 160 CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGG 219
Query: 385 TFCADGADERRCR--HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C D +DE C C+P F+C D C++ + CD + DC D SDE C
Sbjct: 220 PDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC 270
Score = 50.1 bits (118), Expect = 7e-06
Identities = 74/301 (24%), Positives = 98/301 (32%), Gaps = 86/301 (28%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCN--VTLE 197
C Q+EF+C + +C+S CD C DGSDEA C P LT P S CN +
Sbjct: 109 CSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASC-----PVLTCGPA-SFQCNSSTCIP 162
Query: 198 DFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPE 257
+ + P S PQ C L +V+ G P
Sbjct: 163 QLWACDNDPDCED-GSDEWPQRCRGL------------------------YVFQGDSSPC 197
Query: 258 SSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRG------FNATYHVRGYCLPW 311
S A LSG+ + S +W G + C P
Sbjct: 198 S--------------AFEFHCLSGECIHS----SWRCDGGPDCKDKSDEENCAVATCRPD 239
Query: 312 DRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCP----PGHFPCGAAG 367
+ C G+ C +++CD +DC D +DE C P F C +
Sbjct: 240 EFQCSDGN-----------CIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSG- 287
Query: 368 TSGATACYLPADRCNYQTFCADGADE--RRC--RHCQPGN----FRCRDEKCVYETWVCD 419
C CN C D +DE + C C N C D K YE D
Sbjct: 288 -----ECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD 342
Query: 420 G 420
G
Sbjct: 343 G 343
Score = 48.5 bits (114), Expect = 2e-05
Identities = 17/32 (53%), Positives = 22/32 (68%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C+ F+C+D KC+ WVCDG +C DGSDE
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDE 58
Score = 39.3 bits (90), Expect = 0.013
Identities = 18/46 (39%), Positives = 23/46 (50%)
Query: 130 LLSYSQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
L + D C EF CL+ C+ + RCDG C D SDE C+
Sbjct: 187 LYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCA 232
Score = 38.9 bits (89), Expect = 0.017
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
C + EFQC + +C+S CDG C DGSDE+
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDES 59
Score = 35.8 bits (81), Expect = 0.14
Identities = 16/37 (43%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Query: 140 CLQEEFQCLN--HRCVSAVQRCDGVDACGDGSDEAGC 174
C +F C +RC+ RCDG C +GSDE GC
Sbjct: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGC 104
Score = 32.7 bits (73), Expect = 1.2
Identities = 14/34 (41%), Positives = 17/34 (50%)
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
L C FQC + C+ + CD C DGSDE
Sbjct: 146 LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 86.7 bits (213), Expect = 7e-17
Identities = 55/183 (30%), Positives = 85/183 (46%), Gaps = 31/183 (16%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC A +CDG DC D +DE++CP C P FPC + C + RCN
Sbjct: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASG-----IHCIIGRFRCNGFE 95
Query: 386 FCADGADERRCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC-------- 433
C DG+DE C C + C++ C+ ++++CDGQ +C D SDE C
Sbjct: 96 DCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPGS 155
Query: 434 --------SYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIFAPLSRMEA 485
+ ++ IT A+IGS V +L+V L L+ R + + P+ R++
Sbjct: 156 GQVFVTSENQLVYYPSITYAIIGSSVIFVLVVALLALV--LHHQRKRNNLMTLPVHRLQH 213
Query: 486 EIV 488
++
Sbjct: 214 PVL 216
Score = 48.9 bits (115), Expect = 2e-05
Identities = 18/33 (54%), Positives = 22/33 (66%)
Query: 401 PGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
PGNF C + +C+ W CDG PDC D SDE +C
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKEC 64
Score = 40.4 bits (93), Expect = 0.006
Identities = 17/44 (38%), Positives = 21/44 (47%)
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPG 181
L+C + C N C+ CDG + C D SDE C S PG
Sbjct: 111 LLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEPG 154
Score = 38.9 bits (89), Expect = 0.017
Identities = 23/77 (29%), Positives = 32/77 (41%), Gaps = 6/77 (7%)
Query: 145 FQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPS-LPCNVTLEDFYGVF 203
F C N RC+ +CDG+ C D SDE C P + P+ PC + G F
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDEKEC-----PKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 204 SSPGYTHLASVSHPQSC 220
G+ S ++C
Sbjct: 90 RCNGFEDCPDGSDEENC 106
Score = 34.3 bits (77), Expect = 0.41
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 152 CVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPR 185
C+ RC+G + C DGSDE C+++P T R
Sbjct: 84 CIIGRFRCNGFEDCPDGSDEENCTANPLLCSTAR 117
>gi|126012573 low density lipoprotein-related protein 2 [Homo
sapiens]
Length = 4655
Score = 85.9 bits (211), Expect = 1e-16
Identities = 55/167 (32%), Positives = 72/167 (43%), Gaps = 30/167 (17%)
Query: 282 QAVVSYHTVAWSNGRGFNATY---HVRGYCLPWDRPCGLGSG---------LGAGEGLGE 329
Q+ S H + SNG+ + Y HVR D P G L G
Sbjct: 105 QSTCSSHQITCSNGQCIPSEYRCDHVR------DCPDGADENDCQYPTCEQLTCDNGA-- 156
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG-CPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
CY+ +Q+CD DC D +DE +C C F CG C A C++ C
Sbjct: 157 -CYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNG------ECIPRAYVCDHDNDCQ 209
Query: 389 DGADERRCRH--CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
DG+DE C + C F C +C+Y+ WVCDG+ DC D DE C
Sbjct: 210 DGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Score = 81.3 bits (199), Expect = 3e-15
Identities = 44/114 (38%), Positives = 54/114 (47%), Gaps = 11/114 (9%)
Query: 326 GLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGAT---ACYLPADRCN 382
G GE C RCD DC DG+DE +CP H P T C C+
Sbjct: 1075 GHGE-CIPAHWRCDKRNDCVDGSDEHNCPT----HAPASCLDTQYTCDNHQCISKNWVCD 1129
Query: 383 YQTFCADGADERRCRH---CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C DG+DE+ C CQP F C + +C+ ++VCDG DC DGSDE C
Sbjct: 1130 TDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGC 1183
Score = 80.9 bits (198), Expect = 4e-15
Identities = 39/107 (36%), Positives = 52/107 (48%), Gaps = 7/107 (6%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCAD 389
+C RCD DC DG DE DC +P T ACY + +C+++ C D
Sbjct: 119 QCIPSEYRCDHVRDCPDGADENDC------QYPTCEQLTCDNGACYNTSQKCDWKVDCRD 172
Query: 390 GADERRCRH-CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSY 435
+DE C C F C + +C+ +VCD DC DGSDE C+Y
Sbjct: 173 SSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNY 219
Score = 79.3 bits (194), Expect = 1e-14
Identities = 40/114 (35%), Positives = 52/114 (45%), Gaps = 13/114 (11%)
Query: 328 GERCYSEAQRCDGSWDCADGTDEEDCPGCPPG-----HFPCGAAGTSGATACYLPADRCN 382
G++C RCDG +DC+D +DE CP PPG F C G C C+
Sbjct: 1197 GDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDG-----ICIPNFWECD 1251
Query: 383 YQTFCADGADERRC---RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C G+DE + C F C + C++ W+CD DC D SDE DC
Sbjct: 1252 GHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 78.2 bits (191), Expect = 2e-14
Identities = 41/106 (38%), Positives = 54/106 (50%), Gaps = 11/106 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDE-EDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
RC ++ CDG DC DG DE ++C C F CG C RC+
Sbjct: 2964 RCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYG------LCIPKIFRCDRHND 3017
Query: 387 CADGADERRCRH--CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C D +DER C + CQ F C++ +C+ +T+VCD DC DGSDE
Sbjct: 3018 CGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Score = 74.7 bits (182), Expect = 3e-13
Identities = 41/112 (36%), Positives = 49/112 (43%), Gaps = 10/112 (8%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
C +CDG DC D +DEE+C C F C C C++ C
Sbjct: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQ------QCIPSRWICDHYNDCG 3785
Query: 389 DGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLP 438
D +DER C R C P F+C CV+ CDG DC D SDE DC P
Sbjct: 3786 DNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
Score = 74.3 bits (181), Expect = 4e-13
Identities = 39/114 (34%), Positives = 51/114 (44%), Gaps = 15/114 (13%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC CDG DC D +DE+ C C F CG C RC+ +
Sbjct: 1037 RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHG------ECIPAHWRCDKRN 1090
Query: 386 FCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG+DE C C + C + +C+ + WVCD DC DGSDE +C+
Sbjct: 1091 DCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCN 1144
Score = 73.9 bits (180), Expect = 5e-13
Identities = 40/109 (36%), Positives = 52/109 (47%), Gaps = 11/109 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG--CPP-GHFPCGAAGTSGATACYLPADRCNYQTF 386
RC + C+G DC D +DE+ C C P G F C C +C+ Q
Sbjct: 3691 RCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHH------CIPLRWQCDGQND 3744
Query: 387 CADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C D +DE C R C FRC +++C+ W+CD DC D SDE DC
Sbjct: 3745 CGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Score = 73.6 bits (179), Expect = 6e-13
Identities = 40/113 (35%), Positives = 52/113 (46%), Gaps = 15/113 (13%)
Query: 327 LGERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQ 384
+ ++C CD DC D +DE DC C P +F C TSG C +C+
Sbjct: 3767 VNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQC----TSGH--CVHSELKCDGS 3820
Query: 385 TFCADGADERRC-------RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C D +DE C +CQ F C++ C+ W CDG DC DGSDE
Sbjct: 3821 ADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE 3873
Score = 73.6 bits (179), Expect = 6e-13
Identities = 40/108 (37%), Positives = 50/108 (46%), Gaps = 10/108 (9%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGAT-ACYLPADRCNYQTFCAD 389
C +CDGS DC D +DE DCP P C A C P +C+ C D
Sbjct: 3810 CVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGD 3869
Query: 390 GADERR-------CRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
G+DE C P FRC + +C+Y VC+G DC DG+DE
Sbjct: 3870 GSDEELHLCLDVPCN--SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Score = 70.9 bits (172), Expect = 4e-12
Identities = 43/112 (38%), Positives = 55/112 (49%), Gaps = 9/112 (8%)
Query: 330 RCYSEAQRCDGSWDCADGTDE--EDCPGCPPGHFPCGAAGTSGAT--ACYLPADRCNYQT 385
RC +A +CD DC D +DE E+C H S T C CN
Sbjct: 3646 RCIPQAWKCDVDNDCGDHSDEPIEECMSS--AHLCDNFTEFSCKTNYRCIPKWAVCNGVD 3703
Query: 386 FCADGADERRC--RHCQP-GNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C D +DE+ C R C P G+FRC++ C+ W CDGQ DC D SDE +C+
Sbjct: 3704 DCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA 3755
Score = 68.6 bits (166), Expect = 2e-11
Identities = 51/172 (29%), Positives = 63/172 (36%), Gaps = 60/172 (34%)
Query: 307 YCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEED-CPG--CPPGHFPC 363
YC+P C L A E+C +CDG DC+DG+DE CP C G F C
Sbjct: 3507 YCMPM---CSSTQFLCANN---EKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQC 3560
Query: 364 GAAGTSGATACYLPADRCNYQTFCADGADE-------------------RRC-------- 396
C P CN C DG+DE +RC
Sbjct: 3561 SDGN------CTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCD 3614
Query: 397 ------------------RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
R C+PG FRC + +C+ + W CD DC D SDE
Sbjct: 3615 TFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Score = 67.8 bits (164), Expect = 3e-11
Identities = 39/113 (34%), Positives = 53/113 (46%), Gaps = 15/113 (13%)
Query: 330 RCYSEAQRCDGSWDCADGTDEED----CPGCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC SE +CD DC DG+DE + C P F C C + RC+Y
Sbjct: 2711 RCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANG------RCVQYSYRCDYYN 2764
Query: 386 FCADGADERRC--RHCQ-PGNFRCRDEKCVYETWVCDGQPDCADG--SDEWDC 433
C DG+DE C R C F C + +C+ ++C+G +C D SDE +C
Sbjct: 2765 DCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNC 2817
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/84 (44%), Positives = 46/84 (54%), Gaps = 12/84 (14%)
Query: 356 CPPGHFPCGAAGTSGATACYLPAD-RCNYQTFCADGADERRCR--HCQPGNFRCRDE-KC 411
C HF CG+ +PAD RC+ C+D ADE C CQ G F+C+ E +C
Sbjct: 28 CDSAHFRCGSGHC-------IPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQC 80
Query: 412 VYETWVCDGQPDCADGSDE-WDCS 434
+ +WVCD DC DGSDE DCS
Sbjct: 81 IPNSWVCDQDQDCDDGSDERQDCS 104
Score = 63.5 bits (153), Expect = 6e-10
Identities = 39/116 (33%), Positives = 47/116 (40%), Gaps = 18/116 (15%)
Query: 331 CYSEAQRCDGSWDCADGTDEE-----DCPGCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
C +CDG DC DG+DEE D P P F C C + CN
Sbjct: 3854 CIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDN------NRCIYSHEVCNGVD 3907
Query: 386 FCADGADE--RRCRH-----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG DE CR C ++C + C+ VCD DC D SDE C+
Sbjct: 3908 DCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN 3963
Score = 62.4 bits (150), Expect = 1e-09
Identities = 42/150 (28%), Positives = 66/150 (44%), Gaps = 24/150 (16%)
Query: 306 GYCLPWDRPCG-----------LGSGLGAGEGLGERCYSEAQRCDGSW------DCADGT 348
G+C+P D C +G + + +C SE Q SW DC DG+
Sbjct: 38 GHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGS 97
Query: 349 DE-EDCPGCPPGHFPCGAAGTSGATACYLPAD-RCNYQTFCADGADERRCRHCQPGNFRC 406
DE +DC C + + + +P++ RC++ C DGADE C++ C
Sbjct: 98 DERQDC-----SQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTC 152
Query: 407 RDEKCVYETWVCDGQPDCADGSDEWDCSYV 436
+ C + CD + DC D SDE +C+ +
Sbjct: 153 DNGACYNTSQKCDWKVDCRDSSDEINCTEI 182
Score = 62.4 bits (150), Expect = 1e-09
Identities = 35/109 (32%), Positives = 44/109 (40%), Gaps = 15/109 (13%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDC----PGCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C CDG DC D +DE C F C + C C+ +T
Sbjct: 2835 CIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASG------RCIPQHWYCDQETD 2888
Query: 387 CADGADE-RRCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C D +DE C H C F+C +C+ W+CDG DC D SDE
Sbjct: 2889 CFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 58.2 bits (139), Expect = 3e-08
Identities = 43/147 (29%), Positives = 53/147 (36%), Gaps = 32/147 (21%)
Query: 299 NATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG--- 355
N TY C + C G RC + CD DC D +DE G
Sbjct: 2855 NPTYCTTHTCSSSEFQCASG-----------RCIPQHWYCDQETDCFDASDEPASCGHSE 2903
Query: 356 --CPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGN-----FRC-- 406
C F C C C+ C D +DE + CQ N F C
Sbjct: 2904 RTCLADEFKCDGG------RCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVN 2957
Query: 407 ---RDEKCVYETWVCDGQPDCADGSDE 430
D +C+ ++WVCDG DC DG DE
Sbjct: 2958 DRPPDRRCIPQSWVCDGDVDCTDGYDE 2984
Score = 54.7 bits (130), Expect = 3e-07
Identities = 38/116 (32%), Positives = 46/116 (39%), Gaps = 9/116 (7%)
Query: 328 GERCYSEAQRCDGSWDCADGTDEE---DCPG--CPPGHFPCGAAGTSGATACYLPADRCN 382
G RC CDG DC D +DE+ C C F C C + C+
Sbjct: 2915 GGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLC-VNDRPPDRRCIPQSWVCD 2973
Query: 383 YQTFCADGADERR-C--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSY 435
C DG DE + C R C F C C+ + + CD DC D SDE C Y
Sbjct: 2974 GDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLY 3029
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/78 (34%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query: 363 CGAAG-TSGATACYLPADRCNYQTFCADGADERRC----RHCQPGNFRCRDEKCVYETWV 417
CGA+ T C +C+ C DG+DE C P F C + +CV ++
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYR 2759
Query: 418 CDGQPDCADGSDEWDCSY 435
CD DC DGSDE C +
Sbjct: 2760 CDYYNDCGDGSDEAGCLF 2777
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/195 (26%), Positives = 77/195 (39%), Gaps = 25/195 (12%)
Query: 249 VYDGPGP-PESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNA-TYHVRG 306
VYDG P P + + ++++ TVE + + T+ + R F+ YH
Sbjct: 3402 VYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHP-- 3459
Query: 307 YCLPW-DRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADG------TDEEDC-PGCPP 358
Y P PCG +G G C + + +C D + C P C
Sbjct: 3460 YRQPIVSNPCGTNNG-----GCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSS 3514
Query: 359 GHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRC---RHCQPGNFRCRDEKCVYET 415
F C + C +C+ Q C+DG+DE R C+ G F+C D C
Sbjct: 3515 TQFLC-----ANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQ 3569
Query: 416 WVCDGQPDCADGSDE 430
+C+ +C DGSDE
Sbjct: 3570 TLCNAHQNCPDGSDE 3584
Score = 47.0 bits (110), Expect = 6e-05
Identities = 21/46 (45%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 138 LMCLQEEFQCLN-HRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGL 182
L C +F+C + +C+ RCDGV C D SDEAGC + P PG+
Sbjct: 1185 LNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRP-PGM 1229
Score = 47.0 bits (110), Expect = 6e-05
Identities = 20/35 (57%), Positives = 21/35 (60%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C F C N RCV RCD + CGDGSDEAGC
Sbjct: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 45.8 bits (107), Expect = 1e-04
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
CL ++ C NH+C+S CD + CGDGSDE C+S
Sbjct: 1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNS 1145
Score = 45.4 bits (106), Expect = 2e-04
Identities = 73/293 (24%), Positives = 96/293 (32%), Gaps = 54/293 (18%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC------------SSDPFPGLTPRPV 187
C +F C NHRC+ CDG C DGSDE GC S D G+T R
Sbjct: 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCD 1208
Query: 188 PSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAV 247
C+ ++ PG H S C DG + F D G D +
Sbjct: 1209 GVFDCSDNSDEAGCPTRPPGMCH----SDEFQCQ-----EDGICIP-NFWECD-GHPDCL 1257
Query: 248 HVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGY 307
+ D S H NG + L + + + T R
Sbjct: 1258 YGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRD----NDCGDMSDEKDCPTQPFR-- 1311
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEED-CPGCPPGHF----- 361
C W C LG + C + + CDG +DC +GTDE C G F
Sbjct: 1312 CPSWQWQC-LGHNI---------CVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCT 1361
Query: 362 -PCGAAGTSGATACYLPADRCNYQTFCAD-------GADERRCRHCQPGNFRC 406
C C L N C D G+ + C + + G+FRC
Sbjct: 1362 HECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMR-GSFRC 1413
Score = 44.7 bits (104), Expect = 3e-04
Identities = 18/36 (50%), Positives = 21/36 (58%)
Query: 136 DWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
D C F+C NH C+ +CDG D CGDGSDE
Sbjct: 3838 DGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDE 3873
Score = 44.3 bits (103), Expect = 4e-04
Identities = 27/74 (36%), Positives = 35/74 (47%), Gaps = 12/74 (16%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLP-----CNV 194
C EF+C N RC+ ++ C+ +D C D SDE GC G+ PS+ C
Sbjct: 3075 CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC------GINECHDPSISGCDHNCTD 3128
Query: 195 TLEDFYGVFSSPGY 208
TL FY PGY
Sbjct: 3129 TLTSFY-CSCRPGY 3141
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/72 (34%), Positives = 33/72 (45%), Gaps = 9/72 (12%)
Query: 365 AAGTSGATACYLPADR----CNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDG 420
A G +GA C P + N + C ER C +F C + +C+ E W CD
Sbjct: 2667 APGPNGAE-CQCPHEGNWYLANNRKHCIVDNGER----CGASSFTCSNGRCISEEWKCDN 2721
Query: 421 QPDCADGSDEWD 432
DC DGSDE +
Sbjct: 2722 DNDCGDGSDEME 2733
Score = 43.5 bits (101), Expect = 7e-04
Identities = 16/40 (40%), Positives = 22/40 (55%)
Query: 397 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYV 436
+ C +FRC C+ W CDG DC+D +DE C+ V
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
Score = 42.7 bits (99), Expect = 0.001
Identities = 15/32 (46%), Positives = 21/32 (65%)
Query: 144 EFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
+F+C NH C+ +CDG + CGD SDE C+
Sbjct: 3724 DFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA 3755
Score = 42.0 bits (97), Expect = 0.002
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C + EF+C+N +C+ + CD + CGD SDE C
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDC 3793
Score = 41.6 bits (96), Expect = 0.003
Identities = 16/36 (44%), Positives = 21/36 (58%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
C + E++C N C+ CD D CGD SDE GC+
Sbjct: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCN 3963
Score = 41.2 bits (95), Expect = 0.003
Identities = 17/32 (53%), Positives = 20/32 (62%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C Q +F C N RC+S CD + CGDGSDE
Sbjct: 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Score = 40.8 bits (94), Expect = 0.004
Identities = 19/52 (36%), Positives = 27/52 (51%)
Query: 382 NYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
N+ T D +E C +F C++ +CV ++CDG DC D SDE C
Sbjct: 1009 NHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Score = 40.8 bits (94), Expect = 0.004
Identities = 15/27 (55%), Positives = 22/27 (81%)
Query: 145 FQCLNHRCVSAVQRCDGVDACGDGSDE 171
F+C N+RC+ + + C+GVD CGDG+DE
Sbjct: 3889 FRCDNNRCIYSHEVCNGVDDCGDGTDE 3915
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE--------AGCSSDPFPGLTPRP 186
CL +EF+C RC+ + CDG + CGD SDE CS F + RP
Sbjct: 2906 CLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRP 2960
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/37 (43%), Positives = 20/37 (54%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
+CL EF C N C+ CD + C DGSDE C+
Sbjct: 182 ICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACN 218
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/32 (50%), Positives = 19/32 (59%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C F C N RC+S +CD + CGDGSDE
Sbjct: 2700 CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Score = 39.3 bits (90), Expect = 0.013
Identities = 17/35 (48%), Positives = 20/35 (57%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C E FQC + CV + +CDG C D SDEA C
Sbjct: 3798 CHPEYFQCTSGHCVHSELKCDGSADCLDASDEADC 3832
Score = 38.9 bits (89), Expect = 0.017
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
C F+C + C+ A RCDG C D +DE GC+
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/39 (43%), Positives = 20/39 (51%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
C +F C + RC+ CDG D C D DE GC S P
Sbjct: 222 CGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/32 (53%), Positives = 18/32 (56%)
Query: 145 FQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
F C N RCV CDGVD C D SDE C +
Sbjct: 1031 FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGT 1062
Score = 38.9 bits (89), Expect = 0.017
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C + EF C C+ + RCD + CGD SDE GC
Sbjct: 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC 3027
Score = 38.9 bits (89), Expect = 0.017
Identities = 17/32 (53%), Positives = 20/32 (62%), Gaps = 1/32 (3%)
Query: 144 EFQC-LNHRCVSAVQRCDGVDACGDGSDEAGC 174
EF C N+RC+ C+GVD C D SDE GC
Sbjct: 3683 EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGC 3714
Score = 37.4 bits (85), Expect = 0.049
Identities = 29/91 (31%), Positives = 35/91 (38%), Gaps = 13/91 (14%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C A CD DC D +DE+DCP CP + C G C + C+
Sbjct: 1283 CIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQC-----LGHNICVNLSVVCDGIFD 1337
Query: 387 CADGADER---RCRHCQPGNFRCRDEKCVYE 414
C +G DE C N C E CV E
Sbjct: 1338 CPNGTDESPLCNGNSCSDFNGGCTHE-CVQE 1367
Score = 37.0 bits (84), Expect = 0.064
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C + C N +C+ + RCD V C DG+DE C
Sbjct: 108 CSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDC 142
Score = 36.2 bits (82), Expect = 0.11
Identities = 14/32 (43%), Positives = 19/32 (59%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C +F+C N RC+ +CD + CGD SDE
Sbjct: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDE 3666
Score = 35.8 bits (81), Expect = 0.14
Identities = 15/34 (44%), Positives = 20/34 (58%), Gaps = 1/34 (2%)
Query: 139 MCLQEEFQCLNH-RCVSAVQRCDGVDACGDGSDE 171
MC +F C N+ +C+ +CDG C DGSDE
Sbjct: 3511 MCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE 3544
Score = 35.4 bits (80), Expect = 0.18
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C E+QC N RC+ +CD + C D SDE
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/35 (42%), Positives = 18/35 (51%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C F C + C+ A RCD + C DGSDE C
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Score = 34.3 bits (77), Expect = 0.41
Identities = 16/33 (48%), Positives = 18/33 (54%), Gaps = 2/33 (6%)
Query: 144 EFQCLNHRCVSAVQRCDGVDACGDG--SDEAGC 174
EF C N RC+ C+GVD C D SDE C
Sbjct: 2785 EFMCNNRRCIPREFICNGVDNCHDNNTSDEKNC 2817
Score = 33.9 bits (76), Expect = 0.54
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 8/58 (13%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG--------CSSDPFPGLTPRPVPS 189
C EFQC + RC+ CD C D SDE C +D F R +PS
Sbjct: 2864 CSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPS 2921
Score = 32.0 bits (71), Expect = 2.0
Identities = 13/33 (39%), Positives = 17/33 (51%)
Query: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
E+ C N C + Q+CD C D SDE C+
Sbjct: 148 EQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT 180
Score = 32.0 bits (71), Expect = 2.0
Identities = 20/57 (35%), Positives = 25/57 (43%), Gaps = 8/57 (14%)
Query: 140 CLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDE-------AGCSSDPFPGLTPRPVP 188
C +C N C+ V CDG + CGD SDE CSS F + R +P
Sbjct: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIP 2878
Score = 31.6 bits (70), Expect = 2.7
Identities = 24/102 (23%), Positives = 30/102 (29%), Gaps = 37/102 (36%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCAD 389
RC + CDG DC D DE+ C P
Sbjct: 233 RCIYQNWVCDGEDDCKDNGDEDGCESGP-------------------------------- 260
Query: 390 GADERRCRHCQPGNFRCRDE-KCVYETWVCDGQPDCADGSDE 430
C P + C + +C+ VCDG DC DE
Sbjct: 261 ----HDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
Score = 30.8 bits (68), Expect = 4.6
Identities = 13/32 (40%), Positives = 16/32 (50%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C +FQC + C S C+ C DGSDE
Sbjct: 3553 CRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDE 3584
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 84.0 bits (206), Expect = 5e-16
Identities = 40/114 (35%), Positives = 56/114 (49%), Gaps = 11/114 (9%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSG------ATACYLPADRCNYQ 384
C + RC+ + DCAD +DE++C HF T+G + C LP C+
Sbjct: 2603 CIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGS 2662
Query: 385 TFCADGADERRC-----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C D +DE +C C+ F C +C+ TW+CDGQ DC DG DE+ C
Sbjct: 2663 NDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC 2716
Score = 84.0 bits (206), Expect = 5e-16
Identities = 40/109 (36%), Positives = 54/109 (49%), Gaps = 9/109 (8%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
++C RC+G DC D DE DCP C P +F C C C+
Sbjct: 3407 QKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTT-----KHCISKLWVCDEDPD 3461
Query: 387 CADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
CAD +DE C + C P F+C++ C+ + W CD Q DC+D SDE +C
Sbjct: 3462 CADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 3510
Score = 82.4 bits (202), Expect = 1e-15
Identities = 44/111 (39%), Positives = 58/111 (52%), Gaps = 12/111 (10%)
Query: 329 ERCYSEAQRCDGSWDCADGTDE-EDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
++C +CD DC DG+DE +DCP C PG F CG C LPA C+ +
Sbjct: 3327 DKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTG------LCALPAFICDGEN 3380
Query: 386 FCADGADERRC--RHCQPGNFRC-RDEKCVYETWVCDGQPDCADGSDEWDC 433
C D +DE C C G F+C +++KC+ C+GQ DC D DE DC
Sbjct: 3381 DCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Score = 80.1 bits (196), Expect = 7e-15
Identities = 41/110 (37%), Positives = 57/110 (51%), Gaps = 12/110 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC----PGCPPGHFPCGAAGTSGATACYLPADRCNYQT 385
+C +CDG DC G DE+ C P C + C + G C + +CN +
Sbjct: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDG------CISASLKCNGEY 3617
Query: 386 FCADGADERRC-RHCQPGNFRCRDEK-CVYETWVCDGQPDCADGSDEWDC 433
CADG+DE C C+ FRC+++ C+ W+CDG DC DGSDE +C
Sbjct: 3618 DCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 3667
Score = 79.3 bits (194), Expect = 1e-14
Identities = 44/128 (34%), Positives = 56/128 (43%), Gaps = 14/128 (10%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC-PGCPPGHFPCGAA 366
C P C + A +G C S + +C+G +DCADG+DE DC C F C
Sbjct: 3587 CEPASPTCSSREYICASDG----CISASLKCNGEYDCADGSDEMDCVTECKEDQFRC--- 3639
Query: 367 GTSGATACYLPADRCNYQTFCADGADERRCRH----CQPGNFRCRDEKCVYETWVCDGQP 422
C C+ C DG+DE C C+ F C + C WVCDG+
Sbjct: 3640 --KNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCDGED 3697
Query: 423 DCADGSDE 430
DC D SDE
Sbjct: 3698 DCGDNSDE 3705
Score = 77.4 bits (189), Expect = 4e-14
Identities = 40/101 (39%), Positives = 49/101 (48%), Gaps = 12/101 (11%)
Query: 338 CDGSWDCADGTDEEDCP-----GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGAD 392
CDGS DC D +DE CP C +F C + C L C+ Q C DG D
Sbjct: 2659 CDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSG------RCILNTWICDGQKDCEDGRD 2712
Query: 393 ERRC-RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWD 432
E C C F C +KC+ + W+CDG+ DC DG DE D
Sbjct: 2713 EFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
Score = 75.5 bits (184), Expect = 2e-13
Identities = 40/111 (36%), Positives = 49/111 (44%), Gaps = 9/111 (8%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
C + RCD DC+D +DEE+C C F C C C+ CA
Sbjct: 3488 CIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGD------CVSSRFWCDGDFDCA 3541
Query: 389 DGADERRCR-HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLP 438
DG+DER C C FRC + +C+ W CDG DC G DE C P
Sbjct: 3542 DGSDERNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASP 3592
Score = 73.6 bits (179), Expect = 6e-13
Identities = 38/108 (35%), Positives = 50/108 (46%), Gaps = 11/108 (10%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCP-GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCAD 389
C S CDG +DCADG+DE +C C F C C +C+ C
Sbjct: 3527 CVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNG------QCIPAKWKCDGHEDCKY 3580
Query: 390 GADERRCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
G DE+ C C + C + C+ + C+G+ DCADGSDE DC
Sbjct: 3581 GEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC 3628
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/118 (36%), Positives = 55/118 (46%), Gaps = 16/118 (13%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEED--CPG--CPPGHFPCGAAGTSGATACYLPADRCNYQ 384
++C S+ CDG DC DG DE D C C F C G+ AC C+ +
Sbjct: 2730 QKCISKHWICDGEDDCGDGLDESDSICGAITCAADMFSC-----QGSRACVPRHWLCDGE 2784
Query: 385 TFCADGADERRCRHCQPGN------FRCRDEKCVYETWVCDGQPDCADGSDEW-DCSY 435
C DG+DE C P N F C ++ C+ + +VCD DC DGSDE C Y
Sbjct: 2785 RDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGY 2842
Score = 68.9 bits (167), Expect = 2e-11
Identities = 85/323 (26%), Positives = 124/323 (38%), Gaps = 71/323 (21%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-------CSSDPFPGLTPRPVP-SLP 191
C ++F+C N+RC+ CDG + CG DE+ C D F R +P +
Sbjct: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWL 945
Query: 192 CNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLD--PHDGRRLAVRF---TALDLGFGD- 245
C+ ED G + +AS P +C L GR ++ ++ + D G G
Sbjct: 946 CD--REDDCGDQTD----EMASCEFP-TCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSD 998
Query: 246 ---AVH-VYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVS-----YHTVAWSNGR 296
VH +D S R + H++ S +A ++ H+ A NG
Sbjct: 999 EVGCVHSCFDNQFRCSSGRCIPG--HWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGN 1056
Query: 297 GFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGC 356
F H G C+P + RCDG DC DG+DE+ C G
Sbjct: 1057 EFQC--HPDGNCVP-----------------------DLWRCDGEKDCEDGSDEKGCNGT 1091
Query: 357 -----PPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRH--CQPGNFRCRDE 409
F C + G C A C+ C D +DE C C P C ++
Sbjct: 1092 IRLCDHKTKFSCWSTG-----RCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCAND 1146
Query: 410 K--CVYETWVCDGQPDCADGSDE 430
C+ +C+G+ DC DGSDE
Sbjct: 1147 TSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 65.9 bits (159), Expect = 1e-10
Identities = 39/117 (33%), Positives = 48/117 (41%), Gaps = 18/117 (15%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCP-GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
RC S CD DC DG+DE C C F C + C C+ C
Sbjct: 979 RCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSG------RCIPGHWACDGDNDCG 1032
Query: 389 DGADERRCR----------HCQPGNFRCR-DEKCVYETWVCDGQPDCADGSDEWDCS 434
D +DE + C F+C D CV + W CDG+ DC DGSDE C+
Sbjct: 1033 DFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCN 1089
Score = 65.9 bits (159), Expect = 1e-10
Identities = 43/128 (33%), Positives = 50/128 (39%), Gaps = 29/128 (22%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC----------PGCPPGHFPCGAAGTSGATACYLPAD 379
RC CDG DC D +DE GC F C G C
Sbjct: 1017 RCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGN-----CVPDLW 1071
Query: 380 RCNYQTFCADGADERRCRHCQPGNFRCRDEK----------CVYETWVCDGQPDCADGSD 429
RC+ + C DG+DE+ C G R D K C+ + WVCDG DC D SD
Sbjct: 1072 RCDGEKDCEDGSDEKGCN----GTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSD 1127
Query: 430 EWDCSYVL 437
E DC L
Sbjct: 1128 EDDCDSFL 1135
Score = 63.9 bits (154), Expect = 5e-10
Identities = 39/107 (36%), Positives = 45/107 (42%), Gaps = 12/107 (11%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC-PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
RC CDG DC DG DE C C F C A C C+ + C
Sbjct: 2693 RCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFAC------SAQKCISKHWICDGEDDCG 2746
Query: 389 DGADER----RCRHCQPGNFRCRDEK-CVYETWVCDGQPDCADGSDE 430
DG DE C F C+ + CV W+CDG+ DC DGSDE
Sbjct: 2747 DGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE 2793
Score = 61.2 bits (147), Expect = 3e-09
Identities = 33/108 (30%), Positives = 43/108 (39%), Gaps = 14/108 (12%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCP----GCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C +CDG DC DG+DE+ CP F C C C+
Sbjct: 857 CIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQN------NRCIPKRWLCDGAND 910
Query: 387 CADGADERR----CRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
C DE R CQ F C + +C+ W+CD + DC D +DE
Sbjct: 911 CGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDE 958
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/112 (33%), Positives = 47/112 (41%), Gaps = 14/112 (12%)
Query: 330 RCYSEAQRCDGSWDCADGTDEED--CPG--CPPGHFPCGAAGTSGATACYLPADRCNYQT 385
RC + CDG+ DC DE + C C F CG C A C+ +
Sbjct: 897 RCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNG------RCIPRAWLCDRED 950
Query: 386 FCADGADERR-CRH--CQP-GNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C D DE C C+P F C+ +C+ W CD DC DGSDE C
Sbjct: 951 DCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGC 1002
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/113 (33%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATA-CYLPAD-RCNYQTFCA 388
C + CD DC DG+DE P C G+ CG S A C L +C+ C
Sbjct: 2817 CIPKQFVCDHDDDCGDGSDES--PQC--GYRQCGTEEFSCADGRCLLNTQWQCDGDFDCP 2872
Query: 389 DGADER----RCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
D +DE +C+ C F C++ +C+ +CD + DC DGSDE +C
Sbjct: 2873 DHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 57.8 bits (138), Expect = 3e-08
Identities = 39/133 (29%), Positives = 53/133 (39%), Gaps = 15/133 (11%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEE----DCPGCPPGHFPC 363
C+ + C S G G C CDG C D +DE+ + C G PC
Sbjct: 2503 CVTKNSSCNAYSEFECGNG---ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPC 2559
Query: 364 GAAGTSGATACYLPADRCNYQTFCADGADERRCR--HCQPGNFRCRDEKCVYETWVCDGQ 421
C C+ + C D +DE C+ C FRC D C+ + C+
Sbjct: 2560 YNR------RCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQN 2613
Query: 422 PDCADGSDEWDCS 434
DCAD SDE +C+
Sbjct: 2614 IDCADASDEKNCN 2626
Score = 57.8 bits (138), Expect = 3e-08
Identities = 35/111 (31%), Positives = 41/111 (36%), Gaps = 22/111 (19%)
Query: 338 CDGSWDCADGTDEED-------CPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADG 390
CDG DC D +DE CP P C CN C D
Sbjct: 3693 CDGEDDCGDNSDEAPDMCVKFLCPSTRPHR-------CRNNRICLQSEQMCNGIDECGDN 3745
Query: 391 ADERRC--------RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+DE C R C+ F C ++KC+ CD DC DGSDE C
Sbjct: 3746 SDEDHCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 50.4 bits (119), Expect = 6e-06
Identities = 20/46 (43%), Positives = 24/46 (52%)
Query: 385 TFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
T C E C+ G FRC++ C+ W CDG DC DGSDE
Sbjct: 831 TTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDE 876
Score = 50.1 bits (118), Expect = 7e-06
Identities = 23/42 (54%), Positives = 27/42 (64%), Gaps = 2/42 (4%)
Query: 390 GADERRCRHCQPGNFRCRDE-KCVYETWVCDGQPDCADGSDE 430
GAD R + C PG F C D CV ++W+CDG PDC D SDE
Sbjct: 24 GAD-RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDE 64
Score = 49.3 bits (116), Expect = 1e-05
Identities = 19/39 (48%), Positives = 25/39 (64%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
C ++EF C N +C+ +CD +D CGDGSDE GC P
Sbjct: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAP 3800
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/101 (31%), Positives = 40/101 (39%), Gaps = 14/101 (13%)
Query: 331 CYSEAQRCDGSWDCADGTDE--EDCP-----GCPPGHFPCGAAGTSGATACYLPADRCNY 383
C S++ CDG DC D +DE + CP CP H C G C + CN
Sbjct: 45 CVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIAC-----LGTNKCVHLSQLCNG 99
Query: 384 QTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDC 424
C DG DE HCQ C+ C Y+ + C
Sbjct: 100 VLDCPDGYDEG--VHCQELLSNCQQLNCQYKCTMVRNSTRC 138
Score = 48.1 bits (113), Expect = 3e-05
Identities = 21/43 (48%), Positives = 25/43 (58%), Gaps = 1/43 (2%)
Query: 391 ADERRC-RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWD 432
AD R C +C FRC+ +KC+ W CD DC DGSDE D
Sbjct: 3308 ADNRTCLSNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPD 3350
Score = 45.8 bits (107), Expect = 1e-04
Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 10/71 (14%)
Query: 381 CNYQTFCADGADERRC----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYV 436
C+ C D +DE+ R C+ G C + +C+ +CDG+ DC D SDE DC
Sbjct: 2530 CDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC--- 2586
Query: 437 LPRKVITAAVI 447
KV T A +
Sbjct: 2587 ---KVSTCATV 2594
Score = 43.5 bits (101), Expect = 7e-04
Identities = 26/87 (29%), Positives = 37/87 (42%), Gaps = 17/87 (19%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG--------CPPGHFPCGAAGTSGATACYLPAD-RC 381
C Q C+G +C D +DE+ C G C F C + +P D +C
Sbjct: 3729 CLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFAC-------SNKKCIPMDLQC 3781
Query: 382 NYQTFCADGADERRCRHCQPGNFRCRD 408
+ C DG+DE+ CR P + C D
Sbjct: 3782 DRLDDCGDGSDEQGCR-IAPTEYTCED 3807
Score = 43.1 bits (100), Expect = 9e-04
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 7/57 (12%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE-------AGCSSDPFPGLTPRPVP 188
+C EF+C N C+ A +CDG D C DGSDE C D F R +P
Sbjct: 844 ICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIP 900
Score = 42.0 bits (97), Expect = 0.002
Identities = 17/35 (48%), Positives = 19/35 (54%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C F C N RC+ + CD D CGDGSDE C
Sbjct: 2891 CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 40.4 bits (93), Expect = 0.006
Identities = 15/32 (46%), Positives = 20/32 (62%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDE 171
C +F+C +C+ +CD VD CGDGSDE
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE 3348
Score = 40.4 bits (93), Expect = 0.006
Identities = 16/35 (45%), Positives = 19/35 (54%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C EFQC N+ C+ RCD + C D SDE C
Sbjct: 3476 CGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENC 3510
Score = 40.0 bits (92), Expect = 0.008
Identities = 17/40 (42%), Positives = 23/40 (57%), Gaps = 1/40 (2%)
Query: 136 DWLMCLQEEFQCL-NHRCVSAVQRCDGVDACGDGSDEAGC 174
D +CL +F+C N +C+ RC+G D CGD DE C
Sbjct: 3392 DTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Score = 39.7 bits (91), Expect = 0.010
Identities = 14/35 (40%), Positives = 22/35 (62%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +++F+C N +C+ A +CDG + C G DE C
Sbjct: 3553 CSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC 3587
Score = 39.3 bits (90), Expect = 0.013
Identities = 17/37 (45%), Positives = 21/37 (56%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C ++F C N CVS+ CDG C DGSDE C +
Sbjct: 3515 CTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCET 3551
Score = 38.9 bits (89), Expect = 0.017
Identities = 15/38 (39%), Positives = 22/38 (57%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSD 177
C E+ C + C+SA +C+G C DGSDE C ++
Sbjct: 3594 CSSREYICASDGCISASLKCNGEYDCADGSDEMDCVTE 3631
Score = 38.5 bits (88), Expect = 0.022
Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 7/47 (14%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG-------CSSDPF 179
C +F C +C+S CDG D CGDG DE+ C++D F
Sbjct: 2720 CSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/34 (50%), Positives = 19/34 (55%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
+C +EF C N C CDG D CGD SDEA
Sbjct: 3673 ICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEA 3706
Score = 37.7 bits (86), Expect = 0.037
Identities = 15/30 (50%), Positives = 21/30 (70%), Gaps = 1/30 (3%)
Query: 146 QCLNHR-CVSAVQRCDGVDACGDGSDEAGC 174
+C N+R C+ + Q C+G+D CGD SDE C
Sbjct: 3722 RCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Score = 37.4 bits (85), Expect = 0.049
Identities = 14/28 (50%), Positives = 17/28 (60%)
Query: 147 CLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C N RC+ + CDG + CGD SDE C
Sbjct: 2559 CYNRRCIPHGKLCDGENDCGDNSDELDC 2586
Score = 37.4 bits (85), Expect = 0.049
Identities = 15/36 (41%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Query: 140 CLQEEFQCLNH-RCVSAVQRCDGVDACGDGSDEAGC 174
C +++F+C N C+ CDG+ C DGSDE C
Sbjct: 3632 CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC 3667
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/37 (40%), Positives = 18/37 (48%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C + F C + RC+ CDG C DG DE C S
Sbjct: 2682 CEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDS 2718
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/33 (45%), Positives = 18/33 (54%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEA 172
C + F C N C+ CD D CGDGSDE+
Sbjct: 2805 CDENAFMCHNKVCIPKQFVCDHDDDCGDGSDES 2837
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/37 (40%), Positives = 17/37 (45%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C FQC C CDG + CGD SDE C +
Sbjct: 3357 CQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDT 3393
Score = 33.9 bits (76), Expect = 0.54
Identities = 23/62 (37%), Positives = 28/62 (45%), Gaps = 12/62 (19%)
Query: 140 CLQEEFQCLNHRCVSAVQ-RCDGVDACGDGSDEA-----------GCSSDPFPGLTPRPV 187
C EEF C + RC+ Q +CDG C D SDEA C+S F R +
Sbjct: 2845 CGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCI 2904
Query: 188 PS 189
PS
Sbjct: 2905 PS 2906
Score = 33.5 bits (75), Expect = 0.70
Identities = 18/50 (36%), Positives = 25/50 (50%), Gaps = 1/50 (2%)
Query: 124 PMGQGFLLSYSQDWLMCLQEEFQCLNH-RCVSAVQRCDGVDACGDGSDEA 172
P+ + + +D +C EF C +H CVS CDG C D SDE+
Sbjct: 16 PIARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES 65
Score = 33.5 bits (75), Expect = 0.70
Identities = 13/37 (35%), Positives = 19/37 (51%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C EF+C + C+ RC+ C D SDE C++
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNN 2627
Score = 33.1 bits (74), Expect = 0.92
Identities = 13/28 (46%), Positives = 16/28 (57%)
Query: 144 EFQCLNHRCVSAVQRCDGVDACGDGSDE 171
EF+C N C+ CDG+ C D SDE
Sbjct: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDE 2542
Score = 32.7 bits (73), Expect = 1.2
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 140 CLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDEAGC 174
C + FQC + C+S + CD C D SDEA C
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANC 3471
Score = 32.7 bits (73), Expect = 1.2
Identities = 30/127 (23%), Positives = 43/127 (33%), Gaps = 19/127 (14%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
++C +CD DC DG+DE+ C P + C + C +C
Sbjct: 3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEY------------TCEDNVNPCGDDAYCN 3819
Query: 389 DGADERRCRHCQPG------NFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVI 442
CR C+PG N +C D C Q +GS + C +
Sbjct: 3820 QIKTSVFCR-CKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQNFQERNN 3878
Query: 443 TAAVIGS 449
T GS
Sbjct: 3879 TCIAEGS 3885
Score = 32.3 bits (72), Expect = 1.6
Identities = 18/42 (42%), Positives = 21/42 (50%), Gaps = 4/42 (9%)
Query: 138 LMCLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDE---AGCS 175
+ C + F C R CV CDG C DGSDE AGC+
Sbjct: 2759 ITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCA 2800
Score = 30.8 bits (68), Expect = 4.6
Identities = 11/24 (45%), Positives = 13/24 (54%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDC 353
RC CD DC DG+DE +C
Sbjct: 2902 RCIPSGGLCDNKDDCGDGSDERNC 2925
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 83.6 bits (205), Expect = 6e-16
Identities = 49/135 (36%), Positives = 61/135 (45%), Gaps = 10/135 (7%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADG 390
C A RCDG +C D +DEE CP C FPC C RC+ + C D
Sbjct: 1273 CIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARG------QCVDLRLRCDGEADCQDR 1326
Query: 391 ADERRCRH-CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAA---V 446
+DE C C P FRC +CV CD PDC DGSDE C P + A
Sbjct: 1327 SDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSA 1386
Query: 447 IGSLVCGLLLVIALG 461
IG ++ +L + +G
Sbjct: 1387 IGPVIGIILSLFVMG 1401
Score = 58.5 bits (140), Expect = 2e-08
Identities = 31/83 (37%), Positives = 37/83 (44%), Gaps = 4/83 (4%)
Query: 354 PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVY 413
P C P F C +G C A RC+ C D +DE C C F C +CV
Sbjct: 1257 PTCSPDQFACA----TGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVD 1312
Query: 414 ETWVCDGQPDCADGSDEWDCSYV 436
CDG+ DC D SDE DC +
Sbjct: 1313 LRLRCDGEADCQDRSDEADCDAI 1335
Score = 50.1 bits (118), Expect = 7e-06
Identities = 26/73 (35%), Positives = 33/73 (45%), Gaps = 7/73 (9%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG-CPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
+C RCDG DC D +DE DC C P F C + C L +C+ C
Sbjct: 1309 QCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASG------QCVLIKQQCDSFPDCI 1362
Query: 389 DGADERRCRHCQP 401
DG+DE C +P
Sbjct: 1363 DGSDELMCEITKP 1375
Score = 40.0 bits (92), Expect = 0.008
Identities = 16/36 (44%), Positives = 22/36 (61%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
+CL +F+C + +CV Q+CD C DGSDE C
Sbjct: 1335 ICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/42 (40%), Positives = 21/42 (50%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP 180
+C +F C +CV RCDG C D SDEA C + P
Sbjct: 1297 VCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLP 1338
Score = 36.2 bits (82), Expect = 0.11
Identities = 18/46 (39%), Positives = 22/46 (47%), Gaps = 5/46 (10%)
Query: 140 CLQEEFQCLNHR--CVSAVQRCDGVDACGDGSDEAG---CSSDPFP 180
C ++F C C+ RCDG C D SDE G CS+ FP
Sbjct: 1259 CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFP 1304
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 79.0 bits (193), Expect = 1e-14
Identities = 51/142 (35%), Positives = 58/142 (40%), Gaps = 30/142 (21%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPCGA 365
C P + CG S C + CDG DC DG+DE C P C P F CG
Sbjct: 167 CAPHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGG 215
Query: 366 AGTSGATACYLPADRCNYQTFCADGADERR--CRHCQPG------------NFRCRDEKC 411
G AC C+ Q C D +DE C PG F CR +C
Sbjct: 216 ---DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 412 VYETWVCDGQPDCADGSDEWDC 433
V+ W CDG DC D SDE DC
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADC 294
Score = 78.6 bits (192), Expect = 2e-14
Identities = 40/109 (36%), Positives = 52/109 (47%), Gaps = 9/109 (8%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C E +CDG +C DG+DE + CP CG A + RC+ +
Sbjct: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW----RCDGEKD 153
Query: 387 CADGADERRCRH-CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C GADE C C P F+C + C+ +VCDG DC DGSDE C+
Sbjct: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 62.0 bits (149), Expect = 2e-09
Identities = 68/275 (24%), Positives = 86/275 (31%), Gaps = 45/275 (16%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSD--EAGCSSDPFPGLTPRPVPSLPCNVTLE 197
C +F C N C+ +CDG + C DGSD EA C+ P L C T
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVC------PAEKLSCGPTSH 139
Query: 198 DFY-GVFSSPGYTHLASVSHPQSCHWLLDPHD---GRRLAVRFTALDLGFGDAVHVYDGP 253
+ G + C L PH+ G R + + G D D
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER 199
Query: 254 GPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDR 313
G + + R +G + W R F+ R
Sbjct: 200 GCADPACGPREFRCGGDGGGACIPE------------RWVCDRQFDCEDRSDEAAELCGR 247
Query: 314 P----------CGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHF 361
P C S G C RCDG DC D +DE DCP C F
Sbjct: 248 PGPGATSAPAACATASQFACRSG---ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEF 304
Query: 362 PCGAAGTSGATACYLPADRCNYQTFCADGADERRC 396
CG C L CN + C DG+DE C
Sbjct: 305 QCGDG------TCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 54.3 bits (129), Expect = 4e-07
Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 380 RCNYQTFCADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
RC+ C D +DE C + C +F C + C++E W CDG+ +C DGSDE
Sbjct: 65 RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Score = 54.3 bits (129), Expect = 4e-07
Identities = 25/43 (58%), Positives = 29/43 (67%), Gaps = 1/43 (2%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPG 181
+C EFQC N C++AV CDG D CGDGSDE GC +DP G
Sbjct: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC-ADPACG 207
Score = 47.8 bits (112), Expect = 4e-05
Identities = 17/37 (45%), Positives = 23/37 (62%)
Query: 397 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+ C+ F+CR+E+C+ W CD DC D SDE DC
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 44.3 bits (103), Expect = 4e-04
Identities = 18/35 (51%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +++FQC N RC+ +V RCD D C D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/40 (45%), Positives = 25/40 (62%), Gaps = 2/40 (5%)
Query: 139 MCLQEEFQC--LNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
+C E+ C +H+CV A RCDG C G+DEAGC++
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 79.0 bits (193), Expect = 1e-14
Identities = 51/142 (35%), Positives = 58/142 (40%), Gaps = 30/142 (21%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPCGA 365
C P + CG S C + CDG DC DG+DE C P C P F CG
Sbjct: 167 CAPHEFQCGNRS-----------CLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGG 215
Query: 366 AGTSGATACYLPADRCNYQTFCADGADERR--CRHCQPG------------NFRCRDEKC 411
G AC C+ Q C D +DE C PG F CR +C
Sbjct: 216 ---DGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272
Query: 412 VYETWVCDGQPDCADGSDEWDC 433
V+ W CDG DC D SDE DC
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADC 294
Score = 78.6 bits (192), Expect = 2e-14
Identities = 40/109 (36%), Positives = 52/109 (47%), Gaps = 9/109 (8%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C E +CDG +C DG+DE + CP CG A + RC+ +
Sbjct: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW----RCDGEKD 153
Query: 387 CADGADERRCRH-CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C GADE C C P F+C + C+ +VCDG DC DGSDE C+
Sbjct: 154 CEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 62.0 bits (149), Expect = 2e-09
Identities = 68/275 (24%), Positives = 86/275 (31%), Gaps = 45/275 (16%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSD--EAGCSSDPFPGLTPRPVPSLPCNVTLE 197
C +F C N C+ +CDG + C DGSD EA C+ P L C T
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVC------PAEKLSCGPTSH 139
Query: 198 DFY-GVFSSPGYTHLASVSHPQSCHWLLDPHD---GRRLAVRFTALDLGFGDAVHVYDGP 253
+ G + C L PH+ G R + + G D D
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDER 199
Query: 254 GPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDR 313
G + + R +G + W R F+ R
Sbjct: 200 GCADPACGPREFRCGGDGGGACIPE------------RWVCDRQFDCEDRSDEAAELCGR 247
Query: 314 P----------CGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHF 361
P C S G C RCDG DC D +DE DCP C F
Sbjct: 248 PGPGATSAPAACATASQFACRSG---ECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEF 304
Query: 362 PCGAAGTSGATACYLPADRCNYQTFCADGADERRC 396
CG C L CN + C DG+DE C
Sbjct: 305 QCGDG------TCVLAIKHCNQEQDCPDGSDEAGC 333
Score = 54.3 bits (129), Expect = 4e-07
Identities = 22/53 (41%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 380 RCNYQTFCADGADERRC--RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
RC+ C D +DE C + C +F C + C++E W CDG+ +C DGSDE
Sbjct: 65 RCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDE 117
Score = 54.3 bits (129), Expect = 4e-07
Identities = 25/43 (58%), Positives = 29/43 (67%), Gaps = 1/43 (2%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPG 181
+C EFQC N C++AV CDG D CGDGSDE GC +DP G
Sbjct: 166 LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC-ADPACG 207
Score = 47.8 bits (112), Expect = 4e-05
Identities = 17/37 (45%), Positives = 23/37 (62%)
Query: 397 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+ C+ F+CR+E+C+ W CD DC D SDE DC
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 44.3 bits (103), Expect = 4e-04
Identities = 18/35 (51%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +++FQC N RC+ +V RCD D C D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/40 (45%), Positives = 25/40 (62%), Gaps = 2/40 (5%)
Query: 139 MCLQEEFQC--LNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
+C E+ C +H+CV A RCDG C G+DEAGC++
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 79.0 bits (193), Expect = 1e-14
Identities = 83/314 (26%), Positives = 106/314 (33%), Gaps = 79/314 (25%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDF 199
C FQC N C+ CDG C DGSDE DP V E
Sbjct: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDE-----DP---------------VNCEKK 1238
Query: 200 YGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESS 259
F P T + S H C L D DG D H
Sbjct: 1239 CNGFRCPNGTCIPSSKH---CDGLRDCSDG--------------SDEQHCEP-------- 1273
Query: 260 RLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGS 319
THF + + ++V + +G +A + + + C
Sbjct: 1274 ----LCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCD-EF 1328
Query: 320 GLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC------PGCPPG-HFPCGAAGTSGAT 372
G G+ C S +CDG DC D +DE +C P C F C
Sbjct: 1329 GFQCQNGV---CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGH----- 1380
Query: 373 ACYLPADRCNYQTFCADGADERRCRH-------------CQPGNFRCRDEKCVYETWVCD 419
C +C+ + C D +DE+ C C P +RC CV +TWVCD
Sbjct: 1381 -CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCD 1439
Query: 420 GQPDCADGSDEWDC 433
G DCADGSDE C
Sbjct: 1440 GYRDCADGSDEEAC 1453
Score = 72.4 bits (176), Expect = 1e-12
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 10/111 (9%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG--CP-PGHFPCGAAGTSGATACYLPADRCNYQTFC 387
C + CD DC D +DE +CP C F C +GT C + +C+ + C
Sbjct: 1090 CINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGT-----CIPLSYKCDLEDDC 1144
Query: 388 ADGADERRCR--HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYV 436
D +DE C C+ + C C+ +WVCDG DC D SDE +C+ +
Sbjct: 1145 GDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAI 1195
Score = 70.5 bits (171), Expect = 5e-12
Identities = 35/106 (33%), Positives = 48/106 (45%), Gaps = 12/106 (11%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
C + +CD DC D +DE C C + C + C + C+ C
Sbjct: 1131 CIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG------MCIRSSWVCDGDNDCR 1184
Query: 389 DGADERRC----RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
D +DE C C+ NF+CR+ C+ + W CDG DC DGSDE
Sbjct: 1185 DWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
Score = 67.0 bits (162), Expect = 6e-11
Identities = 84/311 (27%), Positives = 108/311 (34%), Gaps = 70/311 (22%)
Query: 146 QCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSS 205
QCL H V CDG+ C DGSDE F G + P +F+ V
Sbjct: 1288 QCLFHSMV-----CDGIIQCRDGSDEDAA----FAGCSQDP-----------EFHKVCDE 1327
Query: 206 PGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLG-FGDAVHVYDGPGPPESSRLLRS 264
G+ V S W D D D G + D + + P SR +
Sbjct: 1328 FGFQCQNGVCI--SLIWKCDGMD-----------DCGDYSDEANCENPTEAPNCSRYFQF 1374
Query: 265 LTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGAG 324
NG + + WS+ + + H+ + P C L +
Sbjct: 1375 --RCENGHCIPNRWKCDR---ENDCGDWSDEKDCGDS-HILPFSTPGPSTC-LPNYYRCS 1427
Query: 325 EGLGERCYSEAQRCDGSWDCADGTDEEDCP---------------GCPPGHFPCGAAGTS 369
G C + CDG DCADG+DEE CP C F C T
Sbjct: 1428 SGT---CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT- 1483
Query: 370 GATACYLPADRCNYQTFCADGADERRC-----RHCQPGNFRCRD-EKCVYETWVCDGQPD 423
C RC+ C DG DE C C F+C D E C+ + CDG D
Sbjct: 1484 ----CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLD 1539
Query: 424 CADGSDEWDCS 434
C+D SDE CS
Sbjct: 1540 CSDESDEKACS 1550
Score = 65.1 bits (157), Expect = 2e-10
Identities = 52/181 (28%), Positives = 69/181 (38%), Gaps = 46/181 (25%)
Query: 292 WSNGRGFNATYHV---------RGYCLP--W----DRPCGLGS------------GLGAG 324
WS+ A YH G+C+P W D C GS G
Sbjct: 1186 WSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCP 1245
Query: 325 EGLGERCYSEAQRCDGSWDCADGTDEEDC-PGCPPGHFPCGAAGTSGATACYLPADRCNY 383
G C ++ CDG DC+DG+DE+ C P C HF C + C+
Sbjct: 1246 NGT---CIPSSKHCDGLRDCSDGSDEQHCEPLCT--HFMDFVC--KNRQQCLFHSMVCDG 1298
Query: 384 QTFCADGADERRC-----------RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWD 432
C DG+DE + C F+C++ C+ W CDG DC D SDE +
Sbjct: 1299 IIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEAN 1358
Query: 433 C 433
C
Sbjct: 1359 C 1359
Score = 48.1 bits (113), Expect = 3e-05
Identities = 19/38 (50%), Positives = 26/38 (68%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
+C + FQC N C+S + +CDG+D CGD SDEA C +
Sbjct: 1324 VCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCEN 1361
Score = 40.8 bits (94), Expect = 0.004
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 138 LMCLQEEFQCLN-HRCVSAVQRCDGVDACGDGSDEAGCSSD 177
L C+ EFQC + C+ +RCDG C D SDE CS +
Sbjct: 1512 LTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
Score = 40.0 bits (92), Expect = 0.008
Identities = 14/35 (40%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
CL+ +++C N C++++ CD + CGD SDE C
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Score = 38.1 bits (87), Expect = 0.029
Identities = 14/35 (40%), Positives = 18/35 (51%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C +RC + C+ W CD DC D SDE +C
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
Score = 37.4 bits (85), Expect = 0.049
Identities = 14/37 (37%), Positives = 22/37 (59%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C +E+ C + C+ + CDG + C D SDEA C++
Sbjct: 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
Score = 35.4 bits (80), Expect = 0.18
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Query: 140 CLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDEAGC 174
C + EF+C + C+ +RCDG C DG DEA C
Sbjct: 1471 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANC 1506
Score = 32.0 bits (71), Expect = 2.0
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 141 LQEEFQCLNH-RCVSAVQRCDGVDACGDGSDEAGC 174
L +F+C C+ +CD D CGD SDE+ C
Sbjct: 1119 LDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHC 1153
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 78.6 bits (192), Expect = 2e-14
Identities = 46/123 (37%), Positives = 56/123 (45%), Gaps = 19/123 (15%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDC---PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFC 387
C CDG DC DG+DE DC P C P FPCG C L RC+ C
Sbjct: 297 CIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNG------HCALKLWRCDGDFDC 350
Query: 388 ADGADERRC------RHCQPGNFRC-RDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRK 440
D DE C C P FRC C+ ++ CD + DC D SDE+ C +P +
Sbjct: 351 EDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC---MPPQ 407
Query: 441 VIT 443
V+T
Sbjct: 408 VVT 410
Score = 58.2 bits (139), Expect = 3e-08
Identities = 30/84 (35%), Positives = 40/84 (47%), Gaps = 4/84 (4%)
Query: 362 PCGAAGTSGATACYLPADR-CNYQTFCADGADERRCRH---CQPGNFRCRDEKCVYETWV 417
PCG + +P D C+ Q C DG+DE C C+P F C + C + W
Sbjct: 284 PCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWR 343
Query: 418 CDGQPDCADGSDEWDCSYVLPRKV 441
CDG DC D +DE +C P +V
Sbjct: 344 CDGDFDCEDRTDEANCPTKRPEEV 367
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/95 (31%), Positives = 39/95 (41%), Gaps = 22/95 (23%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG------CPPGHF 361
C P + PCG G C + RCDG +DC D TDE +CP C P F
Sbjct: 325 CEPNEFPCGNG-----------HCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQF 373
Query: 362 PCGAAGTSGATACYLPADRCNYQTFCADGADERRC 396
C C + C+ ++ C D +DE C
Sbjct: 374 RC-----VSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 40.8 bits (94), Expect = 0.004
Identities = 31/101 (30%), Positives = 36/101 (35%), Gaps = 9/101 (8%)
Query: 78 LACGSERLTLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSYSQDW 137
L C L + L+ PP P TI AP LL S
Sbjct: 232 LNCEEPVLGISPTFSLLVETTSLPPRP------ETTIMRQPPVTHAPQP---LLPGSVRP 282
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
L C +E C N C+ CDG + C DGSDE C P
Sbjct: 283 LPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPP 323
Score = 39.7 bits (91), Expect = 0.010
Identities = 35/127 (27%), Positives = 43/127 (33%), Gaps = 31/127 (24%)
Query: 306 GYCLPWDRPCGLG-----SGLGAG-------EGLGERCYSEAQRCDGSWDCADGTDEEDC 353
GY P + C G SGL G G E C E C G C T+ C
Sbjct: 1131 GYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQG---CQHHTEGPRC 1187
Query: 354 PGCPPGHF--------------PCGAAGTSGATA--CYLPADRCNYQTFCADGADERRCR 397
C PG++ PC +G A C+L D C+ G R C
Sbjct: 1188 EQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCE 1247
Query: 398 HCQPGNF 404
C PG +
Sbjct: 1248 RCAPGYY 1254
Score = 36.6 bits (83), Expect = 0.083
Identities = 16/35 (45%), Positives = 18/35 (51%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C EF C N C + RCDG C D +DEA C
Sbjct: 325 CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC 359
Score = 36.6 bits (83), Expect = 0.083
Identities = 33/113 (29%), Positives = 40/113 (35%), Gaps = 12/113 (10%)
Query: 308 CLPWDRPCGLGSGLGAGE-----GLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFP 362
C P G G LG E G + C+ E C C E C C PG++
Sbjct: 1544 CAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACS---QCQHNAAGEFCELCAPGYYG 1600
Query: 363 CGAAGT---SGATACYLPADRCNYQTFCAD-GADERRCRHCQPGNFRCRDEKC 411
AGT AC L + C GA RC C+PG E+C
Sbjct: 1601 DATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQC 1653
Score = 36.2 bits (82), Expect = 0.11
Identities = 23/67 (34%), Positives = 34/67 (50%), Gaps = 3/67 (4%)
Query: 368 TSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRD-EKCVYETWVCDGQPDCAD 426
+SG+ A Y+ + + +Q F G + R C F C +CV + CD +PDC D
Sbjct: 170 SSGSVASYVTSPQ-GFQ-FRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRD 227
Query: 427 GSDEWDC 433
SDE +C
Sbjct: 228 MSDELNC 234
Score = 36.2 bits (82), Expect = 0.11
Identities = 30/128 (23%), Positives = 44/128 (34%), Gaps = 11/128 (8%)
Query: 313 RPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHF--PCGA-AGTS 369
R G+ + E G+ E ++C C G C C G+ P G GT
Sbjct: 1101 RVSGISMDVAVPEETGQDPALEVEQCS----CPPGYRGPSCQDCDTGYTRTPSGLYLGTC 1156
Query: 370 GATACYLPADRCNYQTFCADGADER----RCRHCQPGNFRCRDEKCVYETWVCDGQPDCA 425
+C+ ++ C +T G RC CQPG + + +C D A
Sbjct: 1157 ERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPA 1216
Query: 426 DGSDEWDC 433
G C
Sbjct: 1217 AGQAAHTC 1224
Score = 35.4 bits (80), Expect = 0.18
Identities = 18/46 (39%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 140 CLQEEFQCLNHR-CVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTP 184
C + EF C ++ CV+ RCD C D SDE C +P G++P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNC-EEPVLGISP 243
Score = 35.4 bits (80), Expect = 0.18
Identities = 30/97 (30%), Positives = 36/97 (37%), Gaps = 24/97 (24%)
Query: 328 GERCYSEAQRCDGSW----DCADGTDEEDCPGCPPGHFPCGAAGTSGATAC------YLP 377
G C A CD + +C T+ C C G F G A + AT+C Y+
Sbjct: 763 GCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFF--GDAMKATATSCRPCPCPYID 820
Query: 378 ADR-----CNYQT-------FCADGADERRCRHCQPG 402
A R C T CA G RRC C PG
Sbjct: 821 ASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPG 857
Score = 31.6 bits (70), Expect = 2.7
Identities = 14/37 (37%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 139 MCLQEEFQCLN-HRCVSAVQRCDGVDACGDGSDEAGC 174
+C +F+C++ + C+ A CD C D SDE GC
Sbjct: 367 VCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 78.2 bits (191), Expect = 2e-14
Identities = 43/132 (32%), Positives = 60/132 (45%), Gaps = 7/132 (5%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADG 390
C A RCDG +C D +DE +CP C F C + C A RCN C D
Sbjct: 1263 CIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASG------QCIDGALRCNGDANCQDK 1316
Query: 391 ADERRCR-HCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIGS 449
+DE+ C C FRC + +C+ + CD DC+D SDE DC +GS
Sbjct: 1317 SDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGS 1376
Query: 450 LVCGLLLVIALG 461
++ ++ + G
Sbjct: 1377 VIGVIVTIFVSG 1388
Score = 56.6 bits (135), Expect = 8e-08
Identities = 31/88 (35%), Positives = 40/88 (45%), Gaps = 7/88 (7%)
Query: 349 DEEDC---PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFR 405
DE C P C P F C +G C A RC+ T C D +DE C C F+
Sbjct: 1239 DELSCGEPPTCSPQQFTC----FTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQ 1294
Query: 406 CRDEKCVYETWVCDGQPDCADGSDEWDC 433
C +C+ C+G +C D SDE +C
Sbjct: 1295 CASGQCIDGALRCNGDANCQDKSDEKNC 1322
Score = 40.0 bits (92), Expect = 0.008
Identities = 17/48 (35%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 138 LMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC--SSDPFPGLT 183
++CL ++F+C N +C+ ++CD C D SDE C + +P P T
Sbjct: 1324 VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQAT 1371
Score = 38.9 bits (89), Expect = 0.017
Identities = 14/36 (38%), Positives = 21/36 (58%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
+C + +FQC + +C+ RC+G C D SDE C
Sbjct: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNC 1322
Score = 37.0 bits (84), Expect = 0.064
Identities = 20/68 (29%), Positives = 31/68 (45%), Gaps = 7/68 (10%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPG-CPPGHFPCGAAGTSGATACYLPADRCNYQTFCA 388
+C A RC+G +C D +DE++C C F C C +C++ C+
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANG------QCIGKHKKCDHNVDCS 1352
Query: 389 DGADERRC 396
D +DE C
Sbjct: 1353 DKSDELDC 1360
Score = 33.5 bits (75), Expect = 0.70
Identities = 14/37 (37%), Positives = 17/37 (45%), Gaps = 2/37 (5%)
Query: 140 CLQEEFQCLNHR--CVSAVQRCDGVDACGDGSDEAGC 174
C ++F C C+ RCDG C D SDE C
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC 1285
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 78.2 bits (191), Expect = 2e-14
Identities = 46/130 (35%), Positives = 54/130 (41%), Gaps = 12/130 (9%)
Query: 306 GYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC--PGCPPGHFPC 363
G+C C G L G C CD DC DG+DEE C PGC G C
Sbjct: 1367 GHCEELVPACAEGEALCQENG---HCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTC 1423
Query: 364 GAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPD 423
+ C A C+ Q C DG DE C G C D +C+ +CDG PD
Sbjct: 1424 SSGH------CLPLALLCDRQDDCGDGTDEPSYP-CPQGLLACADGRCLPPALLCDGHPD 1476
Query: 424 CADGSDEWDC 433
C D +DE C
Sbjct: 1477 CLDAADEESC 1486
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/126 (35%), Positives = 55/126 (43%), Gaps = 18/126 (14%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAG 367
C+P + C G+ LGA Q CDG WDC DG DE PGH P +
Sbjct: 1492 CVPGEVSCVDGTCLGA-----------IQLCDGVWDCPDGADEG------PGHCPLPSLP 1534
Query: 368 TSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADG 427
T A+ P+ + T + A C P FRC +C W CD + DCADG
Sbjct: 1535 TPPASTLPGPSPG-SLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADG 1593
Query: 428 SDEWDC 433
SDE C
Sbjct: 1594 SDERGC 1599
Score = 68.2 bits (165), Expect = 3e-11
Identities = 84/319 (26%), Positives = 109/319 (34%), Gaps = 77/319 (24%)
Query: 139 MCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLED 198
+C +C + CV CDGV C DGSDE GC V L +
Sbjct: 2233 LCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC-------------------VLLPE 2273
Query: 199 FYGVFSSPGYTHLASVSHP-QSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPE 257
G F S T S + P Q HW P +G + H G P
Sbjct: 2274 GTGRFHSTAKTLALSSAQPGQLLHW---PREG-------------LAETEHWPPGQESPT 2317
Query: 258 SSRLLRSLTHFS------NGKAVTVET---------------LSGQAVVSYHTV--AWSN 294
S R ++ +G++V + T ++ VV H V A
Sbjct: 2318 SPTETRPVSPGPASGVPHHGESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPA 2377
Query: 295 GRGFNATYHVRGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCP 354
G+ C P PC E LG C +AQ CDG DC DG+DE C
Sbjct: 2378 GQSVAPGPFPPVQCGPGQTPC---------EVLG--CVEQAQVCDGREDCLDGSDERHCA 2426
Query: 355 GCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYE 414
P A + +T ++ T G R C P C +C+
Sbjct: 2427 RNLLMWLPSLPALWAASTVPFM------MPTMALPGLPASRAL-CSPSQLSCGSGECLSA 2479
Query: 415 TWVCDGQPDCADGSDEWDC 433
CD +PDC DGSDE C
Sbjct: 2480 ERRCDLRPDCQDGSDEDGC 2498
Score = 67.8 bits (164), Expect = 3e-11
Identities = 77/305 (25%), Positives = 105/305 (34%), Gaps = 61/305 (20%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAG--CSSDPFPGLTPRPVP-SLPCNVTL 196
C + + C + C+ CD D CGDG+DE C R +P +L C+
Sbjct: 1416 CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCD--- 1472
Query: 197 EDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGP- 255
G+ + +SC + G V T L A+ + DG
Sbjct: 1473 ----------GHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLG-----AIQLCDGVWDC 1517
Query: 256 PESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPC 315
P+ + + TL G + S T + A C P++ C
Sbjct: 1518 PDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPP-----CGPFEFRC 1572
Query: 316 GLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPG-CPPGHFPCGAAGTSGATAC 374
G G C RCD DCADG+DE C G C P H PC + C
Sbjct: 1573 GSGE-----------CTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPC-----ARGPHC 1616
Query: 375 YLPADRCNYQTFCADGADE---------------RRCRHCQPGNFRCRDEKCVYETWVCD 419
P C+ C DG+DE R C + C + C+ VCD
Sbjct: 1617 VSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCP--EYTCPNGTCIGFQLVCD 1674
Query: 420 GQPDC 424
GQPDC
Sbjct: 1675 GQPDC 1679
Score = 43.1 bits (100), Expect = 9e-04
Identities = 18/36 (50%), Positives = 21/36 (58%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C PG C CV + VCDG+ DC DGSDE C+
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCA 2426
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/101 (31%), Positives = 37/101 (36%), Gaps = 12/101 (11%)
Query: 344 CADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNY-----QTFCADGADERRCRH 398
C +GT P PC S L D N Q C G D C
Sbjct: 1314 CPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHC--GGDGGHCEE 1371
Query: 399 ----CQPGNFRCRDE-KCVYETWVCDGQPDCADGSDEWDCS 434
C G C++ CV W+CD Q DC DGSDE C+
Sbjct: 1372 LVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCA 1412
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/52 (42%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 308 CLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPG 359
C P P L G+G GE C CDG DC DG+DEE C P G
Sbjct: 2224 CEPGSPPAPLCPGVGLRCASGE-CVLRGGPCDGVLDCEDGSDEEGCVLLPEG 2274
Score = 37.7 bits (86), Expect = 0.037
Identities = 18/38 (47%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 140 CLQEEFQCL-NHRCVSAVQRCDGVDACGDGSDEAGCSS 176
C + E C N CV CD D CGDGSDE GC++
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAA 1413
Score = 37.4 bits (85), Expect = 0.049
Identities = 19/52 (36%), Positives = 22/52 (42%), Gaps = 11/52 (21%)
Query: 305 RGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGC 356
R C P CG G C S +RCD DC DG+DE+ C C
Sbjct: 2461 RALCSPSQLSCGSGE-----------CLSAERRCDLRPDCQDGSDEDGCVDC 2501
Score = 37.0 bits (84), Expect = 0.064
Identities = 18/45 (40%), Positives = 21/45 (46%), Gaps = 10/45 (22%)
Query: 399 CQPGN----------FRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C+PG+ RC +CV CDG DC DGSDE C
Sbjct: 2224 CEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 32.0 bits (71), Expect = 2.0
Identities = 24/75 (32%), Positives = 28/75 (37%), Gaps = 13/75 (17%)
Query: 353 CPGCPPGHFPCGAAGTSGATAC-----YLPADRCN------YQTFCADGADERRCR-HCQ 400
CPG PCG SG T C Y+ AD C C D R C HC
Sbjct: 2594 CPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCV 2653
Query: 401 PGNFRCRDEKCVYET 415
G RC +++T
Sbjct: 2654 EG-CRCPPGLLLHDT 2667
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 77.0 bits (188), Expect = 6e-14
Identities = 39/105 (37%), Positives = 51/105 (48%), Gaps = 7/105 (6%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGH-FPCGAAGTSGATACYLPADRCNYQTFCA 388
+C ++RCDG DC D +DEE+C GC + C + C C+ C
Sbjct: 591 QCVLASRRCDGQADCDDDSDEENC-GCKERDLWECPSN-----KQCLKHTVICDGFPDCP 644
Query: 389 DGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
D DE+ C CQ C + CV CDG+ DC+D SDEWDC
Sbjct: 645 DYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 72.0 bits (175), Expect = 2e-12
Identities = 37/107 (34%), Positives = 51/107 (47%), Gaps = 6/107 (5%)
Query: 330 RCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCAD 389
+C + + CDG DC D +DE++C P CG C C+ C D
Sbjct: 317 KCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDG------RCIAMEWVCDGDHDCVD 370
Query: 390 GADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYV 436
+DE C G CR+ +C+ T+ CDG DC DGSDE +CS +
Sbjct: 371 KSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVI 417
Score = 68.6 bits (166), Expect = 2e-11
Identities = 42/121 (34%), Positives = 53/121 (43%), Gaps = 12/121 (9%)
Query: 315 CGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATAC 374
CG G G+ C +C+G DC D +DE C C F C C
Sbjct: 269 CGRGENFLCASGI---CIPGKLQCNGYNDCDDWSDEAHC-NCSENLFHCHTG------KC 318
Query: 375 YLPADRCNYQTFCADGADERRCRHCQP-GNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+ C+ C D +DE+ C C P RC D +C+ WVCDG DC D SDE +C
Sbjct: 319 LNYSLVCDGYDDCGDLSDEQNC-DCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Query: 434 S 434
S
Sbjct: 378 S 378
Score = 60.5 bits (145), Expect = 5e-09
Identities = 39/123 (31%), Positives = 53/123 (43%), Gaps = 22/123 (17%)
Query: 329 ERCYSEAQRCDGSW----DCA----DGTDEEDC-------PGCPPGHFPCGAAGTSGATA 373
ERC S W DC+ + +D + C C P HF C +
Sbjct: 538 ERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSG------Q 591
Query: 374 CYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEK-CVYETWVCDGQPDCADGSDEWD 432
C L + RC+ Q C D +DE C + + C K C+ T +CDG PDC D DE +
Sbjct: 592 CVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKN 651
Query: 433 CSY 435
CS+
Sbjct: 652 CSF 654
Score = 41.2 bits (95), Expect = 0.003
Identities = 17/35 (48%), Positives = 19/35 (54%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +E +C NH CVS CDG C D SDE C
Sbjct: 655 CQDDELECANHACVSRDLWCDGEADCSDSSDEWDC 689
Score = 39.7 bits (91), Expect = 0.010
Identities = 16/39 (41%), Positives = 21/39 (53%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDP 178
C + F C +C++ CDG D CGD SDE C +P
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNP 344
Score = 39.3 bits (90), Expect = 0.013
Identities = 16/35 (45%), Positives = 20/35 (57%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C F+C + +CV A +RCDG C D SDE C
Sbjct: 580 CSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENC 614
Score = 38.5 bits (88), Expect = 0.022
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 146 QCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
+C N +C+ + +CDG + C DGSDE CS
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCS 415
Score = 33.1 bits (74), Expect = 0.92
Identities = 13/33 (39%), Positives = 19/33 (57%)
Query: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
E F C + C+ +C+G + C D SDEA C+
Sbjct: 273 ENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN 305
Score = 32.3 bits (72), Expect = 1.6
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 144 EFQCLNHRCVSAVQRCDGVDACGDGSDEAGCS 175
E +C + RC++ CDG C D SDE CS
Sbjct: 347 EHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS 378
Score = 32.0 bits (71), Expect = 2.0
Identities = 18/61 (29%), Positives = 22/61 (36%), Gaps = 11/61 (18%)
Query: 374 CYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C+ P Q C G NF C C+ C+G DC D SDE C
Sbjct: 256 CFSPQQENGKQLLCGRGE-----------NFLCASGICIPGKLQCNGYNDCDDWSDEAHC 304
Query: 434 S 434
+
Sbjct: 305 N 305
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 75.1 bits (183), Expect = 2e-13
Identities = 89/342 (26%), Positives = 129/342 (37%), Gaps = 44/342 (12%)
Query: 39 QGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHL----ACGSERLTLR-SPLQP 93
+G P D +C W I + + + ++ + L + +C +RL L P P
Sbjct: 152 RGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPEPEGP 211
Query: 94 LISLC-EAPPSPLQLPGGNVTITYSYAGARAPMGQGFLLSY---SQDWLMCLQEEFQCLN 149
L+ +C PP L ++ + + + G GF Y + C +EF+C
Sbjct: 212 LLRVCGRVPPPTLNTNASHLLVVF--VSDSSVEGFGFHAWYQAMAPGRGSCAHDEFRCDQ 269
Query: 150 HRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYT 209
C+ CDG C DGSDE CS+ F G C L G FS+P Y
Sbjct: 270 LICLLPDSVCDGFANCADGSDETNCSA-KFSG----------CGGNLTGLQGTFSTPSY- 317
Query: 210 HLASVSHPQSCHWLLDPHDGRRLAVRF-----TALDLGFGDAVHVYDGPGPPESSRLLRS 264
L H C W + G + ++F A D D V VY+ SS
Sbjct: 318 -LQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYE----TSSSGAFSL 372
Query: 265 LTHFSNGKAVT-VETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLPWDRPCGLGSGLGA 323
L F + + + + V + T + GF+ATY + PCG S L
Sbjct: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFN---ATENPCG-PSELSC 428
Query: 324 GEGLGERCYSEAQRCDGSWDCADGTDEEDCPG--CPPGHFPC 363
G C CD DC DG+D ++C G PP C
Sbjct: 429 QAG---GCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELAC 466
Score = 41.2 bits (95), Expect = 0.003
Identities = 18/36 (50%), Positives = 21/36 (58%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C FRC C+ VCDG +CADGSDE +CS
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCS 295
Score = 35.0 bits (79), Expect = 0.24
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCS 434
C P C+ C W+CD DC DGSD+ +CS
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSDD-NCS 455
Score = 33.5 bits (75), Expect = 0.70
Identities = 44/176 (25%), Positives = 64/176 (36%), Gaps = 27/176 (15%)
Query: 186 PVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCH--WLLDPHDGRRLAVRFTALDLGF 243
P P C L G FSSP Y +P + H W + + ++ AL +
Sbjct: 138 PSPQSTCGGLLSGPRGFFSSPNYPD----PYPPNTHCVWHIQVATDHAIQLKIEALSIE- 192
Query: 244 GDAVHVYD--GPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNAT 301
A ++D P LLR T+ T + +V + + + G GF+A
Sbjct: 193 SVASCLFDRLELSPEPEGPLLRVC---GRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAW 249
Query: 302 YHV----RGYCLPWDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDC 353
Y RG C + C C CDG +CADG+DE +C
Sbjct: 250 YQAMAPGRGSCAHDEFRCD-----------QLICLLPDSVCDGFANCADGSDETNC 294
Score = 32.0 bits (71), Expect = 2.0
Identities = 36/158 (22%), Positives = 49/158 (31%), Gaps = 14/158 (8%)
Query: 35 LLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSE---------RL 85
L +QGT P CTW I ++ ++F L E
Sbjct: 305 LTGLQGTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYET 364
Query: 86 TLRSPLQPLISLCEAPPSPLQLPGGNVTITYSYAGARAPMGQGF---LLSYSQDWLMCLQ 142
+ L C A P P L + + + GF L+++ C
Sbjct: 365 SSSGAFSLLGRFCGAEPPP-HLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGP 423
Query: 143 EEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFP 180
E C C CD C DGSD+ CS FP
Sbjct: 424 SELSCQAGGCKGVQWMCDMWRDCTDGSDD-NCSGPLFP 460
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 72.0 bits (175), Expect = 2e-12
Identities = 72/253 (28%), Positives = 101/253 (39%), Gaps = 38/253 (15%)
Query: 192 CNVTLEDFYGVFSSPGYTHLASVSHPQS--CHWLLDPHDGRRLAVRFT---ALDLGFGDA 246
C L G F+SP Y +P + C W ++ + + + VRF L+ G
Sbjct: 340 CGGRLRKAQGTFNSPYYPG----HYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPG---- 391
Query: 247 VHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRG 306
V G P + + + V + S + V +H+ GF A Y
Sbjct: 392 --VPAGTCPKDYVEI-NGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEY---- 444
Query: 307 YCLPWDR--PCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGH-FPC 363
L +D PC G RC + RCDG DC D +DE +C C GH F C
Sbjct: 445 --LSYDSSDPCPGQFTCRTG-----RCIRKELRCDGWADCTDHSDELNC-SCDAGHQFTC 496
Query: 364 GAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPD 423
C C+ C D +DE+ C C FRC + KC+ ++ C+G+ D
Sbjct: 497 KNK------FCKPLFWVCDSVNDCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQQCNGKDD 549
Query: 424 CADGSDEWDCSYV 436
C DGSDE C V
Sbjct: 550 CGDGSDEASCPKV 562
Score = 70.1 bits (170), Expect = 7e-12
Identities = 41/117 (35%), Positives = 54/117 (46%), Gaps = 13/117 (11%)
Query: 338 CDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCR 397
CD DC D +DE+ C CP F C C + +CN + C DG+DE C
Sbjct: 508 CDSVNDCGDNSDEQGC-SCPAQTFRCSNG------KCLSKSQQCNGKDDCGDGSDEASCP 560
Query: 398 H-----CQPGNFRCRDEKCVYE-TWVCDGQPDCADGSDEWDCSYVLPRKVITAAVIG 448
C +RC + C+ + CDG+ DC+DGSDE DC L A V+G
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVG 617
Score = 49.3 bits (116), Expect = 1e-05
Identities = 19/35 (54%), Positives = 25/35 (71%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C + F+C N +C+S Q+C+G D CGDGSDEA C
Sbjct: 525 CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASC 559
Score = 48.5 bits (114), Expect = 2e-05
Identities = 42/158 (26%), Positives = 58/158 (36%), Gaps = 27/158 (17%)
Query: 35 LLEVQGTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLRSPLQPL 94
L + QGT P +CTW I Q V +RF+ +L L+P
Sbjct: 344 LRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYL------------LEPG 391
Query: 95 ISLCEAPPSPLQLPG--------------GNVTITYSYAGARAPMGQGFLLSY-SQDWLM 139
+ P +++ G + IT + ++ GFL Y S D
Sbjct: 392 VPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSD 451
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSD 177
+F C RC+ RCDG C D SDE CS D
Sbjct: 452 PCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCD 489
Score = 38.1 bits (87), Expect = 0.029
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Query: 140 CLQEEFQCLNHRCVSAVQ-RCDGVDACGDGSDEAGC 174
C + ++CLN C+S CDG + C DGSDE C
Sbjct: 567 CTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 68.9 bits (167), Expect = 2e-11
Identities = 39/114 (34%), Positives = 50/114 (43%), Gaps = 14/114 (12%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
ERC RCD DC D +DE+DCP C F C C +C+ +
Sbjct: 57 ERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG------HCIHERWKCDGEEE 110
Query: 387 CADGADERRC----RHCQPGNFRC--RDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG+DE + C C KCV +W CDG+ DC G+DE C+
Sbjct: 111 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Score = 67.8 bits (164), Expect = 3e-11
Identities = 38/111 (34%), Positives = 49/111 (44%), Gaps = 12/111 (10%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDCPG----CPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
C E +CDG +C DG+DE + CP CG A + RC+ +
Sbjct: 98 CIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASW----RCDGEKD 153
Query: 387 CADGADERRCRH----CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
C GADE C C+ F+C D CV C+ + DC DGSDE C
Sbjct: 154 CEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 47.8 bits (112), Expect = 4e-05
Identities = 17/37 (45%), Positives = 23/37 (62%)
Query: 397 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+ C+ F+CR+E+C+ W CD DC D SDE DC
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 44.3 bits (103), Expect = 4e-04
Identities = 18/35 (51%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +++FQC N RC+ +V RCD D C D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 43.9 bits (102), Expect = 5e-04
Identities = 18/35 (51%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +EFQC + CV A++ C+ C DGSDEAGC
Sbjct: 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/40 (45%), Positives = 25/40 (62%), Gaps = 2/40 (5%)
Query: 139 MCLQEEFQC--LNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
+C E+ C +H+CV A RCDG C G+DEAGC++
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 2/43 (4%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSD--EAGCSSDPFP 180
C +F C N C+ +CDG + C DGSD EA C+ P
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCP 128
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 68.9 bits (167), Expect = 2e-11
Identities = 39/114 (34%), Positives = 50/114 (43%), Gaps = 14/114 (12%)
Query: 329 ERCYSEAQRCDGSWDCADGTDEEDCP--GCPPGHFPCGAAGTSGATACYLPADRCNYQTF 386
ERC RCD DC D +DE+DCP C F C C +C+ +
Sbjct: 57 ERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNG------HCIHERWKCDGEEE 110
Query: 387 CADGADERRC----RHCQPGNFRC--RDEKCVYETWVCDGQPDCADGSDEWDCS 434
C DG+DE + C C KCV +W CDG+ DC G+DE C+
Sbjct: 111 CPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Score = 47.8 bits (112), Expect = 4e-05
Identities = 17/37 (45%), Positives = 23/37 (62%)
Query: 397 RHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDC 433
+ C+ F+CR+E+C+ W CD DC D SDE DC
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 44.3 bits (103), Expect = 4e-04
Identities = 18/35 (51%), Positives = 23/35 (65%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
C +++FQC N RC+ +V RCD D C D SDE C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDC 81
Score = 41.6 bits (96), Expect = 0.003
Identities = 18/40 (45%), Positives = 25/40 (62%), Gaps = 2/40 (5%)
Query: 139 MCLQEEFQC--LNHRCVSAVQRCDGVDACGDGSDEAGCSS 176
+C E+ C +H+CV A RCDG C G+DEAGC++
Sbjct: 126 VCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT 165
Score = 38.1 bits (87), Expect = 0.029
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 2/43 (4%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSD--EAGCSSDPFP 180
C +F C N C+ +CDG + C DGSD EA C+ P
Sbjct: 86 CADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCP 128
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 68.6 bits (166), Expect = 2e-11
Identities = 42/117 (35%), Positives = 49/117 (41%), Gaps = 30/117 (25%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDC--PGC-------PPGHFPCGAAGTSGATACYLPADRC 381
C RCD DC+DG+DEE+C C PP PC G S
Sbjct: 67 CVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCPPPPGLPCPCTGVSD----------- 115
Query: 382 NYQTFCADGADE--RRCRH--CQPGNFRCR-DEKCVYETWVCDGQPDCADGSDEWDC 433
C+ G D+ R C C G RC + C+ TW CDG PDC D SDE C
Sbjct: 116 -----CSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGC 167
Score = 39.7 bits (91), Expect = 0.010
Identities = 25/59 (42%), Positives = 28/59 (47%), Gaps = 4/59 (6%)
Query: 140 CLQEEFQC-LNHRCVSAVQRCDGVDACGDGSDEAGCSSDPF--PGLTPRPVPSLPCNVT 195
C +FQC + CV RCD C DGSDE C +P G P P P LPC T
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQKGQCP-PPPGLPCPCT 111
Score = 39.3 bits (90), Expect = 0.013
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 138 LMCLQEEFQC-LNHRCVSAVQRCDGVDACGDGSDEAGCSSD 177
L CL E +C L+ C+ RCDG C D SDE GC ++
Sbjct: 130 LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTN 170
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 66.2 bits (160), Expect = 1e-10
Identities = 43/118 (36%), Positives = 54/118 (45%), Gaps = 13/118 (11%)
Query: 338 CDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCR 397
CDG DC +G DE +C C F C T C C+ Q C +G+DE +C+
Sbjct: 474 CDGVKDCPNGLDERNCV-CR-ATFQCKEDST-----CISLPKVCDGQPDCLNGSDEEQCQ 526
Query: 398 H---CQPGNFRCRDEKCVYE-TWVCDGQPDCADGSDE--WDCSYVLPRKVITAAVIGS 449
C F+C D CV + CDG+PDC DGSDE DC P I + S
Sbjct: 527 EGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSS 584
Score = 53.9 bits (128), Expect = 5e-07
Identities = 33/82 (40%), Positives = 42/82 (51%), Gaps = 11/82 (13%)
Query: 358 PGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCR-DEKCVYETW 416
PG F C G +PA C+ C +G DER C C+ F+C+ D C+
Sbjct: 459 PGEFLCSVNGLC------VPA--CDGVKDCPNGLDERNCV-CR-ATFQCKEDSTCISLPK 508
Query: 417 VCDGQPDCADGSDEWDCSYVLP 438
VCDGQPDC +GSDE C +P
Sbjct: 509 VCDGQPDCLNGSDEEQCQEGVP 530
Score = 44.3 bits (103), Expect = 4e-04
Identities = 25/67 (37%), Positives = 32/67 (47%), Gaps = 4/67 (5%)
Query: 331 CYSEAQRCDGSWDCADGTDEEDC-PGCPPGHFPCGAAGTSGATACYLPADRCNYQTFCAD 389
C S + CDG DC +G+DEE C G P G F S P +C+ + C D
Sbjct: 503 CISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRS---CVKKPNPQCDGRPDCRD 559
Query: 390 GADERRC 396
G+DE C
Sbjct: 560 GSDEEHC 566
Score = 33.5 bits (75), Expect = 0.70
Identities = 17/41 (41%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 135 QDWLMCLQEEFQCLNHRCVSAVQ-RCDGVDACGDGSDEAGC 174
Q+ + C FQC + CV +CDG C DGSDE C
Sbjct: 526 QEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHC 566
Score = 32.0 bits (71), Expect = 2.0
Identities = 43/181 (23%), Positives = 63/181 (34%), Gaps = 42/181 (23%)
Query: 36 LEVQGTLQRPLVRDSRTSPANCTWLI--------LGSKEQTVTIRFQKLHLACGSERLTL 87
L+ QG L P + +C+W + L +R QK L C + T+
Sbjct: 345 LDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTI 404
Query: 88 RSP----LQPLISLCEAPP------------SPLQLPGGNVTITYSYAGARAPMGQGFLL 131
++ L+ L E P S + L G V + Y P FL
Sbjct: 405 QNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLC 464
Query: 132 SYSQ----------------DWLMCL-QEEFQCL-NHRCVSAVQRCDGVDACGDGSDEAG 173
S + D C+ + FQC + C+S + CDG C +GSDE
Sbjct: 465 SVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQ 524
Query: 174 C 174
C
Sbjct: 525 C 525
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 60.8 bits (146), Expect = 4e-09
Identities = 45/132 (34%), Positives = 58/132 (43%), Gaps = 28/132 (21%)
Query: 313 RPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSGAT 372
+PC +GS GL C +AQRCDG DC D +DE C P
Sbjct: 356 QPCPVGS-FRCSSGL---CVPQAQRCDGVNDCFDESDELFCVSPQP-------------- 397
Query: 373 ACYLPADR------CNYQTFCADGADERRCRHCQPGN---FRCRDEKCV-YETWVCDGQP 422
AC + R C+ C +G DE+ C P N F+C ++ C + CDG
Sbjct: 398 ACNTSSFRQHGPLICDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTV 457
Query: 423 DCADGSDEWDCS 434
DC DGSDE C+
Sbjct: 458 DCPDGSDEEGCT 469
Score = 43.9 bits (102), Expect = 5e-04
Identities = 27/84 (32%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 356 CPPGHFPCGAAGTSGATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKC-VYE 414
CP G F C + C A RC+ C D +DE C QP C +
Sbjct: 358 CPVGSFRCSSG------LCVPQAQRCDGVNDCFDESDELFCVSPQPA---CNTSSFRQHG 408
Query: 415 TWVCDGQPDCADGSDEWDCSYVLP 438
+CDG DC +G DE +C+ +P
Sbjct: 409 PLICDGFRDCENGRDEQNCTQSIP 432
Score = 41.2 bits (95), Expect = 0.003
Identities = 25/81 (30%), Positives = 36/81 (44%), Gaps = 11/81 (13%)
Query: 140 CLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDF 199
C F+C + CV QRCDGV+ C D SDE C ++P+P CN +
Sbjct: 358 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC-------VSPQPA----CNTSSFRQ 406
Query: 200 YGVFSSPGYTHLASVSHPQSC 220
+G G+ + Q+C
Sbjct: 407 HGPLICDGFRDCENGRDEQNC 427
Score = 38.9 bits (89), Expect = 0.017
Identities = 22/57 (38%), Positives = 27/57 (47%), Gaps = 5/57 (8%)
Query: 399 CQPGNFRCRDEKCVYETWVCDGQPDCADGSDEWDCSYVLPRKVITAAVI---GSLVC 452
C G+FRC CV + CDG DC D SDE C V P+ + G L+C
Sbjct: 358 CPVGSFRCSSGLCVPQAQRCDGVNDCFDESDELFC--VSPQPACNTSSFRQHGPLIC 412
Score = 34.7 bits (78), Expect = 0.32
Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 140 CLQEEFQCLNHRCVSAVQ-RCDGVDACGDGSDEAGCS 175
C F+C N C +CDG C DGSDE GC+
Sbjct: 433 CNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGCT 469
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 53.9 bits (128), Expect = 5e-07
Identities = 67/272 (24%), Positives = 111/272 (40%), Gaps = 18/272 (6%)
Query: 40 GTLQRPLVRDSRTSPANCTWLILGSKEQTVTIRFQKLHLACGSERLTLR---SPLQPLIS 96
GT+ P D + NCTW+I S + V F HL G + L + S QPL
Sbjct: 933 GTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGHDYLLITENGSFTQPLRQ 992
Query: 97 LCEAP-PSPLQLP-GGNVTITYSYAGARAPMGQGFLLSYSQ-DWLMCLQEEFQCLNHRCV 153
L + P+P+ GN T + + +GF +++S+ D C + E + R
Sbjct: 993 LTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPCEEPEVPAYSIRKG 1052
Query: 154 SAVQRCDGVD-ACGDGSDEAGCSSDPFPG------LTPRPVPSLPCNVTLEDFYGVFSSP 206
D + +C G G + G +P P C ++ G SP
Sbjct: 1053 LQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSP 1112
Query: 207 GYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLT 266
+ + ++ C + + G+ + ++ A +L GD + VYDG S+RLL +
Sbjct: 1113 NFP--VNYNNNHECIYSIQTQPGKGIQLKARAFELSEGDVLKVYDGNN--NSARLLGVFS 1168
Query: 267 HFSNGKAVTVETLSGQAVVSYHTVAWSNGRGF 298
H S VT+ + S + + T A + +GF
Sbjct: 1169 H-SEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/260 (22%), Positives = 99/260 (38%), Gaps = 20/260 (7%)
Query: 57 CTWLILGSKEQTVTIRFQKLHLACGSERLTL---RSPLQPLISLCEAPPSPLQLPGGNVT 113
C W + S + + + F +L G + L + R L PLI P ++ + +
Sbjct: 1471 CDWKVTVSPDYVIALVFNIFNLEPGYDFLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNS 1530
Query: 114 ITYSYAGARAPMGQGFLLSYSQDWLMCLQEEFQCLNHRCV--------SAVQRCDG---V 162
+ ++ + GF++ Y+++ + N V S C G V
Sbjct: 1531 LFLAFRSDASVSNAGFVIDYTENPRESCFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEV 1590
Query: 163 DACGDGSDEAGCSSDPFPGLTPRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHW 222
+ S G P PRPV + PC GV SP Y + + Q C +
Sbjct: 1591 EGTSTLSCILGPDGKPVWN-NPRPVCTAPCGGQYVGSDGVVLSPNYPQ--NYTSGQICLY 1647
Query: 223 LLDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLTHFSNGKAVTVETLSGQ 282
+ + +F D V V+DG + SRLL SL+ G+++ + T S Q
Sbjct: 1648 FVTVPKDYVVFGQFAFFHTALNDVVEVHDGHS--QHSRLLSSLSGSHTGESLPLAT-SNQ 1704
Query: 283 AVVSYHTVAWSNGRGFNATY 302
++ + + RGF+ Y
Sbjct: 1705 VLIKFSAKGLAPARGFHFVY 1724
Score = 38.5 bits (88), Expect = 0.022
Identities = 34/116 (29%), Positives = 53/116 (45%), Gaps = 11/116 (9%)
Query: 192 CNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFT--ALDLGFGDAVHV 249
C L G SPG+ + + +C W + + R+ + F AL+ F D + V
Sbjct: 26 CTFQLHGPNGTVESPGFPY--GYPNYANCTWTITAEEQHRIQLVFQSFALEEDF-DVLSV 82
Query: 250 YDGPGPPESSRLLRSLTHFS-NGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHV 304
+DGP PE+ R LT F V+ T ++S + V + +GF+ATY V
Sbjct: 83 FDGPPQPENLR--TRLTGFQLPATIVSAATTLSLRLISDYAV---SAQGFHATYEV 133
Score = 38.1 bits (87), Expect = 0.029
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 11/115 (9%)
Query: 184 PRPVPSLPCNVTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDL-G 242
P P +PC + G SPG+ + S Q C WL+ G + + + L
Sbjct: 2174 PLPKCEVPCGGNITSSNGTVYSPGFP--SPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP 2231
Query: 243 FGDAVHVYDGP--GPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNG 295
GD + ++DGP P RS+ TV++ S Q ++ +H A + G
Sbjct: 2232 SGDFITIWDGPQQTAPRLGVFTRSMA------KKTVQSSSNQVLLKFHRDAATGG 2280
>gi|194363725 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin c2 isoform c [Homo sapiens]
Length = 1152
Score = 52.4 bits (124), Expect = 1e-06
Identities = 40/130 (30%), Positives = 50/130 (38%), Gaps = 26/130 (20%)
Query: 578 ARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAPTTVPEA 637
A + V P+ A A G GP+ + G G G Q P AP P A P P
Sbjct: 1020 APASVVPAPAGSGAPPGSLGPSEQIGQAGSTAGPQQQQ-PAGAPQPGAVPPGVPPPGPHG 1078
Query: 638 PGPLPSLPLEPSLLSG----------------VVQALRGRLLPSLG---------PPGPT 672
P P P+ PS++ G +V A++G LLPS PP PT
Sbjct: 1079 PSPFPNQQTPPSMMPGAVPGSGHPGVAAQSPAIVAAVQGNLLPSASPLPDPGTPLPPDPT 1138
Query: 673 RSPPGPHTAV 682
PG T V
Sbjct: 1139 APSPGTVTPV 1148
>gi|239749482 PREDICTED: hypothetical protein [Homo sapiens]
Length = 195
Score = 50.4 bits (119), Expect = 6e-06
Identities = 47/142 (33%), Positives = 55/142 (38%), Gaps = 27/142 (19%)
Query: 572 PARASEARSQVTPSAAPLEALDGGTGPAREGGAVGGQDGEQAPPLPIKAPLPSASTSPAP 631
PA A + P+AA L AL R G GG G+ A PLP P +PA
Sbjct: 52 PAAAHPPAPRERPAAARLSALAAAQPRRRSPGPQGGGGGDIASPLP---PALQPRGAPAV 108
Query: 632 TTVPEAPGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGPHTAVL---ALEDE 688
P +PGPLP+ P P PP P+ P GPH VL AL
Sbjct: 109 PAAP-SPGPLPARPSSP-------------------PPRPS-LPSGPHRPVLPPSALAAP 147
Query: 689 DDVLLVPLAEPGVWVAEAEDEP 710
L PL + V E E P
Sbjct: 148 RPPLARPLPQGSVTAREQEQRP 169
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.446
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,931,210
Number of Sequences: 37866
Number of extensions: 2256220
Number of successful extensions: 17020
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 807
Number of HSP's that attempted gapping in prelim test: 11639
Number of HSP's gapped (non-prelim): 4613
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.