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Search of human proteins with 31982873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens]
(348 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens] 714 0.0
gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens] 670 0.0
gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens] 662 0.0
gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens] 632 0.0
gi|13027388 STE20-related kinase adaptor beta [Homo sapiens] 295 5e-80
gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yea... 139 5e-33
gi|4826878 oxidative-stress responsive 1 [Homo sapiens] 138 6e-33
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 105 8e-23
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 105 8e-23
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 103 2e-22
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 102 7e-22
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 101 9e-22
gi|29826329 p21-activated kinase 7 [Homo sapiens] 100 1e-21
gi|24308191 p21-activated kinase 7 [Homo sapiens] 100 1e-21
gi|191252782 p21-activated kinase 6 [Homo sapiens] 99 4e-21
gi|191252780 p21-activated kinase 6 [Homo sapiens] 99 4e-21
gi|9910476 p21-activated kinase 6 [Homo sapiens] 99 4e-21
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 98 1e-20
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 97 2e-20
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 97 3e-20
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 97 3e-20
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 97 3e-20
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 97 3e-20
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 97 3e-20
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 97 3e-20
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 96 6e-20
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 96 6e-20
gi|110611908 mitogen-activated protein kinase kinase kinase kina... 94 1e-19
gi|6005810 mitogen-activated protein kinase kinase kinase kinase... 94 1e-19
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 93 3e-19
>gi|31982873 protein kinase LYK5 isoform 3 [Homo sapiens]
Length = 348
Score = 714 bits (1842), Expect = 0.0
Identities = 348/348 (100%), Positives = 348/348 (100%)
Query: 1 MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV 60
MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV
Sbjct: 1 MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV 60
Query: 61 TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD 120
TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD
Sbjct: 61 TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD 120
Query: 121 LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN 180
LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN
Sbjct: 121 LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN 180
Query: 181 LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV 240
LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV
Sbjct: 181 LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV 240
Query: 241 PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG 300
PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG
Sbjct: 241 PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG 300
Query: 301 DSPSHPYHRTFSPHFHHFVEQCLQRNPDARYPCWPGPGLRESRGCSGG 348
DSPSHPYHRTFSPHFHHFVEQCLQRNPDARYPCWPGPGLRESRGCSGG
Sbjct: 301 DSPSHPYHRTFSPHFHHFVEQCLQRNPDARYPCWPGPGLRESRGCSGG 348
>gi|51242960 protein kinase LYK5 isoform 2 [Homo sapiens]
Length = 394
Score = 670 bits (1728), Expect = 0.0
Identities = 330/330 (100%), Positives = 330/330 (100%)
Query: 1 MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV 60
MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV
Sbjct: 1 MSFLTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYV 60
Query: 61 TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD 120
TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD
Sbjct: 61 TVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKD 120
Query: 121 LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN 180
LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN
Sbjct: 121 LICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSN 180
Query: 181 LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV 240
LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV
Sbjct: 181 LSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHV 240
Query: 241 PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG 300
PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG
Sbjct: 241 PFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNG 300
Query: 301 DSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 330
DSPSHPYHRTFSPHFHHFVEQCLQRNPDAR
Sbjct: 301 DSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 330
>gi|51242955 protein kinase LYK5 isoform 1 [Homo sapiens]
Length = 431
Score = 662 bits (1709), Expect = 0.0
Identities = 326/326 (100%), Positives = 326/326 (100%)
Query: 5 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 64
TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR
Sbjct: 42 TNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRR 101
Query: 65 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 124
INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT
Sbjct: 102 INLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICT 161
Query: 125 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 184
HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI
Sbjct: 162 HFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMI 221
Query: 185 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 244
SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD
Sbjct: 222 SHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKD 281
Query: 245 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 304
MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS
Sbjct: 282 MPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPS 341
Query: 305 HPYHRTFSPHFHHFVEQCLQRNPDAR 330
HPYHRTFSPHFHHFVEQCLQRNPDAR
Sbjct: 342 HPYHRTFSPHFHHFVEQCLQRNPDAR 367
>gi|51242957 protein kinase LYK5 isoform 4 [Homo sapiens]
Length = 373
Score = 632 bits (1630), Expect = 0.0
Identities = 309/309 (100%), Positives = 309/309 (100%)
Query: 22 MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE 81
MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE
Sbjct: 1 MSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGE 60
Query: 82 LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 141
LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG
Sbjct: 61 LHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQG 120
Query: 142 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 201
VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV
Sbjct: 121 VLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSV 180
Query: 202 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 261
KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC
Sbjct: 181 KVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPC 240
Query: 262 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ 321
LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ
Sbjct: 241 LLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQ 300
Query: 322 CLQRNPDAR 330
CLQRNPDAR
Sbjct: 301 CLQRNPDAR 309
>gi|13027388 STE20-related kinase adaptor beta [Homo sapiens]
Length = 418
Score = 295 bits (754), Expect = 5e-80
Identities = 153/300 (51%), Positives = 200/300 (66%), Gaps = 1/300 (0%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
YEL IG+GF++L +V+LAR+ PTG VT++ NLE C+ E + LQ + +S F HP
Sbjct: 58 YELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCNEERLKALQKAVILSHFFRHP 117
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NI Y F + LWV++ FMAYGSA L+ T+F +GM+E I IL G ++ L+Y+H
Sbjct: 118 NITTYWTVFTVGSWLWVISPFMAYGSASQLLRTYFPEGMSETLIRNILFGAVRGLNYLHQ 177
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
G +HRS+KASHILIS DG V LSGL S++ HGQR R V+DFP++S V PWLSPE+
Sbjct: 178 NGCIHRSIKASHILISGDGLVTLSGLSHLHSLVKHGQRHRAVYDFPQFSTSVQPWLSPEL 237
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAE 271
L+Q+L GY+ KSDIYSVGITACELA+G VPF+DM TQMLL+KL G LD S P
Sbjct: 238 LRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFPQS 297
Query: 272 ELTMSPSRSVANSGLSDS-LTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDAR 330
E M S+S +SG+ +S L +S N D P +TFSP F V+ CLQ++P+ R
Sbjct: 298 ESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKR 357
>gi|115430252 serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
[Homo sapiens]
Length = 545
Score = 139 bits (349), Expect = 5e-33
Identities = 87/237 (36%), Positives = 128/237 (54%), Gaps = 12/237 (5%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
YEL VIG G + V A KP E V ++RINLE C M L+ E+ +HP
Sbjct: 63 YELQEVIGSGATAV--VQAALCKPRQERVAIKRINLEKCQTSMDELLK-EIQAMSQCSHP 119
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLIC------THFMDGMNELAIAYILQGVLKA 145
N+V Y +F+ +ELW+V ++ GS D+I H + E IA IL+ VL+
Sbjct: 120 NVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEG 179
Query: 146 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 205
LDY+H G +HR +KA +IL+ DG V ++ + + + G R + K V
Sbjct: 180 LDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTR--NKVRKTFVGTPC 237
Query: 206 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCL 262
W++PEV++Q ++GYD K+D++S GITA ELA G P+ P ++L+ L P L
Sbjct: 238 WMAPEVMEQ-VRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTL 293
>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
Length = 527
Score = 138 bits (348), Expect = 6e-33
Identities = 88/237 (37%), Positives = 128/237 (54%), Gaps = 12/237 (5%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
YEL VIG G + V A P E V ++RINLE C M L+ E+ +HP
Sbjct: 17 YELQEVIGSGATAV--VQAAYCAPKKEKVAIKRINLEKCQTSMDELLK-EIQAMSQCHHP 73
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLIC------THFMDGMNELAIAYILQGVLKA 145
NIV Y +F+ +ELW+V ++ GS D+I H ++E IA IL+ VL+
Sbjct: 74 NIVSYYTSFVVKDELWLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEG 133
Query: 146 LDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLP 205
L+Y+H G +HR VKA +IL+ DG V ++ + + + G R + K V
Sbjct: 134 LEYLHKNGQIHRDVKAGNILLGEDGSVQIADFGVSAFLATGGDITR--NKVRKTFVGTPC 191
Query: 206 WLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCL 262
W++PEV++Q ++GYD K+DI+S GITA ELA G P+ P ++L+ L P L
Sbjct: 192 WMAPEVMEQ-VRGYDFKADIWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPSL 247
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 105 bits (261), Expect = 8e-23
Identities = 69/219 (31%), Positives = 118/219 (53%), Gaps = 17/219 (7%)
Query: 56 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 115
T + V ++ I+LE +E + +Q E+ V + P + Y +++ D +LW++ ++
Sbjct: 46 TQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG 104
Query: 116 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 175
GSA DL+ +D E IA IL+ +LK LDY+H +HR +KA+++L+S G+V L+
Sbjct: 105 GSALDLLEPGPLD---ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLA 161
Query: 176 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 233
G+ L+ + V F W++PEV++Q+ YD+K+DI+S+GITA
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDSKADIWSLGITAI 210
Query: 234 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEE 272
ELA G P ++ ++L P L + P +E
Sbjct: 211 ELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE 249
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 105 bits (261), Expect = 8e-23
Identities = 69/219 (31%), Positives = 118/219 (53%), Gaps = 17/219 (7%)
Query: 56 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 115
T + V ++ I+LE +E + +Q E+ V + P + Y +++ D +LW++ ++
Sbjct: 58 TQKVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGG 116
Query: 116 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 175
GSA DL+ +D E IA IL+ +LK LDY+H +HR +KA+++L+S G+V L+
Sbjct: 117 GSALDLLEPGPLD---ETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLA 173
Query: 176 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 233
G+ L+ + V F W++PEV++Q+ YD+K+DI+S+GITA
Sbjct: 174 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDSKADIWSLGITAI 222
Query: 234 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEE 272
ELA G P ++ ++L P L + P +E
Sbjct: 223 ELARGEPPHSELHPMKVLFLIPKNNPPTLEGNYSKPLKE 261
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 103 bits (258), Expect = 2e-22
Identities = 63/214 (29%), Positives = 116/214 (54%), Gaps = 16/214 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
+++L +G+G +V A +K TG+ V ++++ +E+ E++ E+ + + + P
Sbjct: 30 FDVLEKLGEG--SYGSVYKAIHKETGQIVAIKQVPVESDLQEIIK----EISIMQQCDSP 83
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
++V Y ++ + +LW+V + GS D+I + E IA ILQ LK L+Y+H
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT-LTEDEIATILQSTLKGLEYLHF 142
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
M +HR +KA +IL++ +G L+ + ++ V P W++PEV
Sbjct: 143 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-------WMAPEV 195
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDM 245
+Q+ GY+ +DI+S+GITA E+A G P+ D+
Sbjct: 196 IQE--IGYNCVADIWSLGITAIEMAEGKPPYADI 227
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 102 bits (253), Expect = 7e-22
Identities = 70/219 (31%), Positives = 115/219 (52%), Gaps = 17/219 (7%)
Query: 56 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 115
T E V ++ I+LE +E + +Q E+ V + P I Y +++ +LW++ ++
Sbjct: 42 TKEVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSPYITRYFGSYLKSTKLWIIMEYLGG 100
Query: 116 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 175
GSA DL+ + E IA IL+ +LK LDY+H +HR +KA+++L+S G V L+
Sbjct: 101 GSALDLLKP---GPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLA 157
Query: 176 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 233
G+ L+ + V F W++PEV++Q+ YD K+DI+S+GITA
Sbjct: 158 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIKQS--AYDFKADIWSLGITAI 206
Query: 234 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEE 272
ELA G P D+ ++L + P L + P +E
Sbjct: 207 ELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQHSKPFKE 245
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 101 bits (252), Expect = 9e-22
Identities = 68/214 (31%), Positives = 113/214 (52%), Gaps = 17/214 (7%)
Query: 56 TGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAY 115
T + V ++ I+LE +E + +Q E+ V + + Y +++ ++LW++ ++
Sbjct: 46 TQQVVAIKIIDLEEAEDE-IEDIQQEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGG 104
Query: 116 GSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLS 175
GSA DL+ D E IA +L+ +LK LDY+H +HR +KA+++L+S G V L+
Sbjct: 105 GSALDLLRAGPFD---EFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLA 161
Query: 176 --GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITAC 233
G+ L+ + V F W++PEV+QQ+ YD+K+DI+S+GITA
Sbjct: 162 DFGVAGQLTDTQIKRNTFVGTPF---------WMAPEVIQQS--AYDSKADIWSLGITAI 210
Query: 234 ELANGHVPFKDMPATQMLLEKLNGTVPCLLDTST 267
ELA G P DM ++L P L+ T
Sbjct: 211 ELAKGEPPNSDMHPMRVLFLIPKNNPPTLVGDFT 244
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 100 bits (250), Expect = 1e-21
Identities = 66/216 (30%), Positives = 116/216 (53%), Gaps = 20/216 (9%)
Query: 38 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 97
IG+G ++ + A K TG+ V V++++L + F E+ + + ++H N+V
Sbjct: 455 IGEGSTGIVCI--ATEKHTGKQVAVKKMDLRKQQRRELLF--NEVVIMRDYHHDNVVDMY 510
Query: 98 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 157
++++ +ELWVV F+ G+ D++ TH MNE IA + VL+AL Y+H+ G +HR
Sbjct: 511 SSYLVGDELWVVMEFLEGGALTDIV-THTR--MNEEQIATVCLSVLRALSYLHNQGVIHR 567
Query: 158 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 215
+K+ IL++ DG++ LS G +V + PK V W++PEV+ +
Sbjct: 568 DIKSDSILLTSDGRIKLS---------DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISR- 617
Query: 216 LQGYDAKSDIYSVGITACELANGHVPFKDMPATQML 251
Y + DI+S+GI E+ +G P+ + P Q +
Sbjct: 618 -LPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAM 652
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 100 bits (250), Expect = 1e-21
Identities = 66/216 (30%), Positives = 116/216 (53%), Gaps = 20/216 (9%)
Query: 38 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 97
IG+G ++ + A K TG+ V V++++L + F E+ + + ++H N+V
Sbjct: 455 IGEGSTGIVCI--ATEKHTGKQVAVKKMDLRKQQRRELLF--NEVVIMRDYHHDNVVDMY 510
Query: 98 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 157
++++ +ELWVV F+ G+ D++ TH MNE IA + VL+AL Y+H+ G +HR
Sbjct: 511 SSYLVGDELWVVMEFLEGGALTDIV-THTR--MNEEQIATVCLSVLRALSYLHNQGVIHR 567
Query: 158 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 215
+K+ IL++ DG++ LS G +V + PK V W++PEV+ +
Sbjct: 568 DIKSDSILLTSDGRIKLS---------DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISR- 617
Query: 216 LQGYDAKSDIYSVGITACELANGHVPFKDMPATQML 251
Y + DI+S+GI E+ +G P+ + P Q +
Sbjct: 618 -LPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAM 652
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 99.4 bits (246), Expect = 4e-21
Identities = 72/232 (31%), Positives = 119/232 (51%), Gaps = 23/232 (9%)
Query: 38 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 97
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 98 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 157
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 158 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 215
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 216 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTS 266
L Y + DI+S+GI E+ +G P F D P M ++L + P L S
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--KRLRDSPPPKLKNS 624
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 99.4 bits (246), Expect = 4e-21
Identities = 72/232 (31%), Positives = 119/232 (51%), Gaps = 23/232 (9%)
Query: 38 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 97
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 98 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 157
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 158 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 215
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 216 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTS 266
L Y + DI+S+GI E+ +G P F D P M ++L + P L S
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--KRLRDSPPPKLKNS 624
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 99.4 bits (246), Expect = 4e-21
Identities = 72/232 (31%), Positives = 119/232 (51%), Gaps = 23/232 (9%)
Query: 38 IGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYR 97
IG+G + V LAR K +G V V+ ++L + F E+ + + + H N+V
Sbjct: 413 IGEGSTGI--VCLAREKHSGRQVAVKMMDLRKQQRRELLF--NEVVIMRDYQHFNVVEMY 468
Query: 98 ATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHR 157
+++ ELWV+ F+ G+ D++ +NE IA + + VL+AL Y+H G +HR
Sbjct: 469 KSYLVGEELWVLMEFLQGGALTDIVS---QVRLNEEQIATVCEAVLQALAYLHAQGVIHR 525
Query: 158 SVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYS--VKVLPWLSPEVLQQN 215
+K+ IL+++DG+V LS G ++ D PK V W++PEV+ ++
Sbjct: 526 DIKSDSILLTLDGRVKLS---------DFGFCAQISKDVPKRKSLVGTPYWMAPEVISRS 576
Query: 216 LQGYDAKSDIYSVGITACELANGHVP-FKDMPATQMLLEKLNGTVPCLLDTS 266
L Y + DI+S+GI E+ +G P F D P M ++L + P L S
Sbjct: 577 L--YATEVDIWSLGIMVIEMVDGEPPYFSDSPVQAM--KRLRDSPPPKLKNS 624
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 98.2 bits (243), Expect = 1e-20
Identities = 73/236 (30%), Positives = 118/236 (50%), Gaps = 16/236 (6%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
+EL+ IG G V AR TGE ++ I LE E +Q E+ + K HP
Sbjct: 16 FELIQRIGSGTYG--DVYKARNVNTGELAAIKVIKLEP--GEDFAVVQQEIIMMKDCKHP 71
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ ++LW+ F GS +D+ H ++EL IAY+ + L+ L Y+H
Sbjct: 72 NIVAYFGSYLRRDKLWICMEFCGGGSLQDIY--HVTGPLSELQIAYVSRETLQGLYYLHS 129
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
G +HR +K ++IL++ +G V L+ + + + +++ P W++PEV
Sbjct: 130 KGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPY-------WMAPEV 182
Query: 212 LQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQ--MLLEKLNGTVPCLLD 264
+ GY+ D+++VGITA ELA P D+ + L+ K N P L D
Sbjct: 183 AAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKD 238
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 97.1 bits (240), Expect = 2e-20
Identities = 60/214 (28%), Positives = 115/214 (53%), Gaps = 16/214 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
+++L +G+G +V A +K +G+ V ++++ +E+ E++ E+ + + + P
Sbjct: 27 FDVLEKLGEG--SYGSVFKAIHKESGQVVAIKQVPVESDLQEIIK----EISIMQQCDSP 80
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
+V Y ++ + +LW+V + GS D+I + E IA IL+ LK L+Y+H
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKT-LIEDEIATILKSTLKGLEYLHF 139
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
M +HR +KA +IL++ +G L+ + ++ V P W++PEV
Sbjct: 140 MRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPF-------WMAPEV 192
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPFKDM 245
+Q+ GY+ +DI+S+GIT+ E+A G P+ D+
Sbjct: 193 IQE--IGYNCVADIWSLGITSIEMAEGKPPYADI 224
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 283 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 338
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 339 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 395
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 396 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 448
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 449 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 494
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 289 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 344
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 345 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 401
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 402 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 454
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 455 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 500
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 304 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 359
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 360 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 416
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 417 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 469
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 470 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 515
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 268 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 323
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 380
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 381 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 433
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 434 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 479
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 268 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 323
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 380
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 381 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 433
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 434 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 479
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 96.7 bits (239), Expect = 3e-20
Identities = 71/228 (31%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 268 YTRFEKIGQGASG--TVYTALDIATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 323
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+ALD++H
Sbjct: 324 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALDFLHS 380
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 381 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 433
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 434 VTR--KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGT 479
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 95.5 bits (236), Expect = 6e-20
Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 270 YTRFEKIGQGASG--TVYTAMDVATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 325
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+AL+++H
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALEFLHS 382
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 383 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 435
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 436 VTR--KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 95.5 bits (236), Expect = 6e-20
Identities = 70/228 (30%), Positives = 117/228 (51%), Gaps = 17/228 (7%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y IG+G TV A TG+ V ++++NL+ + + E+ V + +P
Sbjct: 270 YTRFEKIGQGASG--TVYTAMDVATGQEVAIKQMNLQQQPKKELII--NEILVMRENKNP 325
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +ELWVV ++A GS D++ MD E IA + + L+AL+++H
Sbjct: 326 NIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD---EGQIAAVCRECLQALEFLHS 382
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K+ +IL+ +DG V L+ + I+ Q +R Y W++PEV
Sbjct: 383 NQVIHRDIKSDNILLGMDGSVKLTDF-GFCAQITPEQSKRSTMVGTPY------WMAPEV 435
Query: 212 LQQNLQGYDAKSDIYSVGITACELANGHVPF-KDMPATQMLLEKLNGT 258
+ + + Y K DI+S+GI A E+ G P+ + P + L NGT
Sbjct: 436 VTR--KAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGT 481
>gi|110611908 mitogen-activated protein kinase kinase kinase kinase
1 isoform 1 [Homo sapiens]
Length = 821
Score = 94.4 bits (233), Expect = 1e-19
Identities = 68/221 (30%), Positives = 115/221 (52%), Gaps = 14/221 (6%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y+LL +G G V AR K +G+ V ++ + +E ++ V+ LQ E+ + K H
Sbjct: 17 YDLLQRLGGGTYG--EVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRHA 72
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +LW+ F GS +D+ ++EL I+Y+ + VL+ L Y+H
Sbjct: 73 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIY--QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K ++ILI+ G+V L+ + + + R+ P W++PEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPEV 183
Query: 212 LQQNLQ-GYDAKSDIYSVGITACELANGHVPFKDMPATQML 251
L+ GY+ DI+S+GITA ELA P D+ ++L
Sbjct: 184 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVL 224
>gi|6005810 mitogen-activated protein kinase kinase kinase kinase 1
isoform 2 [Homo sapiens]
Length = 833
Score = 94.4 bits (233), Expect = 1e-19
Identities = 68/221 (30%), Positives = 115/221 (52%), Gaps = 14/221 (6%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
Y+LL +G G V AR K +G+ V ++ + +E ++ V+ LQ E+ + K H
Sbjct: 17 YDLLQRLGGGTYG--EVFKARDKVSGDLVALKMVKMEP--DDDVSTLQKEILILKTCRHA 72
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y +++ +LW+ F GS +D+ ++EL I+Y+ + VL+ L Y+H
Sbjct: 73 NIVAYHGSYLWLQKLWICMEFCGAGSLQDIY--QVTGSLSELQISYVCREVLQGLAYLHS 130
Query: 152 MGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEV 211
+HR +K ++ILI+ G+V L+ + + + R+ P W++PEV
Sbjct: 131 QKKIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLSFIGTPY-------WMAPEV 183
Query: 212 LQQNLQ-GYDAKSDIYSVGITACELANGHVPFKDMPATQML 251
L+ GY+ DI+S+GITA ELA P D+ ++L
Sbjct: 184 AAVALKGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVL 224
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 93.2 bits (230), Expect = 3e-19
Identities = 71/238 (29%), Positives = 118/238 (49%), Gaps = 20/238 (8%)
Query: 32 YELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHP 91
YEL+ +G G V AR TGE V+ I LE + + +Q E+ + K H
Sbjct: 20 YELVQRVGSGTYG--DVYKARNVHTGELAAVKIIKLEP--GDDFSLIQQEIFMVKECKHC 75
Query: 92 NIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHH 151
NIV Y ++++ +LW+ + GS +D+ H ++EL IAY+ + L+ L Y+H
Sbjct: 76 NIVAYFGSYLSREKLWICMEYCGGGSLQDIY--HVTGPLSELQIAYVCRETLQGLAYLHT 133
Query: 152 MGYVHRSVKASHILISVDGKVYLS--GLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSP 209
G +HR +K ++IL++ G V L+ G+ + ++ ++ + + W++P
Sbjct: 134 KGKMHRDIKGANILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPY---------WMAP 184
Query: 210 EVLQ-QNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQ--MLLEKLNGTVPCLLD 264
EV + GY+ DI++VGITA EL P D+ + L+ K N P L D
Sbjct: 185 EVAAVEKNGGYNQLCDIWAVGITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKD 242
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,505,879
Number of Sequences: 37866
Number of extensions: 615115
Number of successful extensions: 3274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 366
Number of HSP's successfully gapped in prelim test: 317
Number of HSP's that attempted gapping in prelim test: 2317
Number of HSP's gapped (non-prelim): 813
length of query: 348
length of database: 18,247,518
effective HSP length: 103
effective length of query: 245
effective length of database: 14,347,320
effective search space: 3515093400
effective search space used: 3515093400
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.