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Search of human proteins with 31742482
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31742482 arylsulfatase F precursor [Homo sapiens]
(590 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31742482 arylsulfatase F precursor [Homo sapiens] 1241 0.0
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 723 0.0
gi|58743319 arylsulfatase family, member H [Homo sapiens] 707 0.0
gi|157266309 arylsulfatase E precursor [Homo sapiens] 688 0.0
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 561 e-160
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 362 e-100
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 219 7e-57
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 219 7e-57
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 219 7e-57
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 219 7e-57
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 153 5e-37
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 145 1e-34
gi|45430057 Arylsulfatase G [Homo sapiens] 134 2e-31
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 98 2e-20
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 98 2e-20
gi|109389362 arylsulfatase J [Homo sapiens] 94 4e-19
gi|59797060 arylsulfatase family, member I [Homo sapiens] 91 3e-18
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 76 1e-13
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 76 1e-13
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 60 4e-09
gi|39930577 arylsulfatase K [Homo sapiens] 57 4e-08
gi|189571643 sulfatase 1 [Homo sapiens] 50 6e-06
gi|189571641 sulfatase 1 [Homo sapiens] 50 6e-06
gi|189571638 sulfatase 1 [Homo sapiens] 50 6e-06
gi|189571636 sulfatase 1 [Homo sapiens] 50 6e-06
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 49 1e-05
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 49 1e-05
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 49 1e-05
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 47 6e-05
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 42 0.002
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 1241 bits (3210), Expect = 0.0
Identities = 590/590 (100%), Positives = 590/590 (100%)
Query: 1 MRPRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDR 60
MRPRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDR
Sbjct: 1 MRPRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDR 60
Query: 61 LAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETT 120
LAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETT
Sbjct: 61 LAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETT 120
Query: 121 LAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRN 180
LAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRN
Sbjct: 121 LAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRN 180
Query: 181 TELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSP 240
TELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSP
Sbjct: 181 TELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSP 240
Query: 241 LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD 300
LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD
Sbjct: 241 LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD 300
Query: 301 DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLG 360
DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLG
Sbjct: 301 DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLG 360
Query: 361 GWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQ 420
GWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQ
Sbjct: 361 GWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQ 420
Query: 421 DRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPP 480
DRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPP
Sbjct: 421 DRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPP 480
Query: 481 ASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKE 540
ASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKE
Sbjct: 481 ASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKE 540
Query: 541 HQETIVPVTYQLSELNQGRTWLKPCCGVFPFCLCDKEEEVSQPRGPNEKR 590
HQETIVPVTYQLSELNQGRTWLKPCCGVFPFCLCDKEEEVSQPRGPNEKR
Sbjct: 541 HQETIVPVTYQLSELNQGRTWLKPCCGVFPFCLCDKEEEVSQPRGPNEKR 590
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 723 bits (1867), Expect = 0.0
Identities = 343/575 (59%), Positives = 417/575 (72%), Gaps = 2/575 (0%)
Query: 4 RRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAR 63
R L + +C LL TC+ + KPNI+LIM DDLG GDLGCYGN+T+RTP+ID+LA
Sbjct: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
Query: 64 EGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAA 123
EGVRLTQH++AA LC+PSR+AFLTGR+ RSGM +S R +Q A GLP NETT A
Sbjct: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
Query: 124 LLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTEL 183
+L++ GY+TGLIGKWHQG+NC SR D CHHP N+GFDY+YGMPFTL + C P +
Sbjct: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
Query: 184 AFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYW 243
A +QLW Q +A+ ILTL G+ G+ SV + M L +W+SS W
Sbjct: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
Query: 244 DCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFT 303
+C+LMR H++TEQPM E+ S+M+KEA+S++ERH FLLF S LHVH PL TT F
Sbjct: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
Query: 304 GTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWN 363
G S+HGLYGDNVEEMD ++GK+L+AI+D GL+N+T YFTSDHGGHLEAR GH+QLGGWN
Sbjct: 315 GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWN 374
Query: 364 GIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRV 423
GIYKGGKGMGGWEGGIRVPGI WPG +PAGR+I EPTSLMD+ PTV + GG +PQDRV
Sbjct: 375 GIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRV 434
Query: 424 IDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASG 483
IDG L+PLLQG S HEFLFHYCG +LHA RW K DSGSVWK HY TP F P +G
Sbjct: 435 IDGHSLVPLLQGAEARSAHEFLFHYCGQHLHAARWHQK-DSGSVWKVHYTTPQFHPEGAG 493
Query: 484 GCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQE 543
CY +C C GE VT+H PPLLFDLSRDPSE+ PLTP +EPL+ VI +V A+ EH++
Sbjct: 494 ACYGRGVCPCSGEGVTHHRPPLLFDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQ 553
Query: 544 TIVPVTYQLSELN-QGRTWLKPCCGVFPFCLCDKE 577
T+ PV Q S N + WL+PCCG FPFC C ++
Sbjct: 554 TLSPVPQQFSMSNILWKPWLQPCCGHFPFCSCHED 588
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 707 bits (1824), Expect = 0.0
Identities = 335/554 (60%), Positives = 410/554 (74%), Gaps = 4/554 (0%)
Query: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
+PNIVL+M DDLG+GDL CYGN+++ TP+IDRLA EGVRLTQH++AAS+C+PSR+AFLTG
Sbjct: 6 RPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTG 65
Query: 89 RYPIRSGMVSSGN-RRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSR 147
RYPIRSGMVS+ N R L GLP NETT A LL+ +GY TGLIGKWH GL+C SR
Sbjct: 66 RYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASR 125
Query: 148 SDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGK 207
+D C+HP N+GF Y+YG+PF L+ C + +LW+ +A+ L K
Sbjct: 126 NDHCYHPLNHGFHYFYGVPFGLLSDCQASKTPELHRWLRIKLWISTVALALVPFLLLIPK 185
Query: 208 LSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIM 267
+ W SVPW +IF L FL +W+SS+ W+C+LMR HEI +QPMK E+ S+M
Sbjct: 186 FARWFSVPWKVIFVFALLAFLFFTSWYSSYGFTRRWNCILMRNHEIIQQPMKEEKVASLM 245
Query: 268 VKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILD 327
+KEA++F+ER+ +E FLLFFSFLHVHTPL + F G SK+G YGDNVEEMD MVGKILD
Sbjct: 246 LKEALAFIERYKREPFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEMDWMVGKILD 305
Query: 328 AIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRW 387
A+D L N+TLVYFTSD+GGHLE G QLGGWNGIYKGGKGMGGWEGGIRVPGI RW
Sbjct: 306 ALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGGIRVPGIFRW 365
Query: 388 PGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFH 447
P + AGR+I EPTSLMDI PT++ + GG L QDRVIDG++LMPLL+G HS+HEFLFH
Sbjct: 366 PSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLLEGRASHSDHEFLFH 425
Query: 448 YCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLF 507
YCG YLH VRW K D +VWKAHYVTP F P +G CY + +C C G+ VTYH+PPLLF
Sbjct: 426 YCGVYLHTVRWHQK-DCATVWKAHYVTPKFYPEGTGACYGSGICSCSGD-VTYHDPPLLF 483
Query: 508 DLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQ-GRTWLKPCC 566
D+SRDPSE+ PL P EPL D VIKK+ A++EH+ T+ PV Q S N + WL+PCC
Sbjct: 484 DISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQQFSVFNTIWKPWLQPCC 543
Query: 567 GVFPFCLCDKEEEV 580
G FPFC CDKE+++
Sbjct: 544 GTFPFCGCDKEDDI 557
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 688 bits (1775), Expect = 0.0
Identities = 329/553 (59%), Positives = 415/553 (75%), Gaps = 4/553 (0%)
Query: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
+PNI+L+M DDLGIGD+GCYGN+TMRTP+IDRLA +GV+LTQHISAASLC+PSR+AFLTG
Sbjct: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTG 96
Query: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRS 148
RYP+RSGMVSS RV+Q GLP NETT A +LK++GY+TGLIGKWH GLNC+S S
Sbjct: 97 RYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGYATGLIGKWHLGLNCESAS 156
Query: 149 DQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGKL 208
D CHHP ++GFD++YGMPF+L+ C + E +L Q++A+ LTL GKL
Sbjct: 157 DHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLNFLFQVLALVALTLVAGKL 216
Query: 209 SGWVSVPWL-LIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIM 267
+ + V W+ +I+S + + LL ++F ++ DC LMR H ITEQPM +R ++
Sbjct: 217 THLIPVSWMPVIWSALSAVLLLASSYFVGALI-VHADCFLMRNHTITEQPMCFQRTTPLI 275
Query: 268 VKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILD 327
++E SFL+R+ FLLF SFLHVH PL T ++F G S HGLYGDNVEEMD MVG+ILD
Sbjct: 276 LQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMVGRILD 335
Query: 328 AIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRW 387
+D GL N+TL+YFTSDHGG LE + G+ Q GGWNGIYKGGKGMGGWEGGIRVPGI RW
Sbjct: 336 TLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVPGIFRW 395
Query: 388 PGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFH 447
PG +PAGR+I EPTSLMD+ PTV ++GG +PQDRVIDG+DL+PLL G +HS+HEFL H
Sbjct: 396 PGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDHEFLMH 455
Query: 448 YCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLF 507
YC +LHA RW + D G++WK H+VTPVFQP +G CY +C CFGE+V +H+PPLLF
Sbjct: 456 YCERFLHAARWHQR-DRGTMWKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPLLF 514
Query: 508 DLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSEL-NQGRTWLKPCC 566
DLSRDPSE+ LTPA+EP+ V+++V A+ EHQ T+ PV QL L N R WL+PCC
Sbjct: 515 DLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNIWRPWLQPCC 574
Query: 567 GVFPFCLCDKEEE 579
G FP C C +E++
Sbjct: 575 GPFPLCWCLREDD 587
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 561 bits (1445), Expect = e-160
Identities = 284/582 (48%), Positives = 384/582 (65%), Gaps = 11/582 (1%)
Query: 3 PRRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLA 62
P R + L+ L ++H +PNI+L+M DDLGIGD GCYGN T+RTP+IDRLA
Sbjct: 2 PLRKMKIPFLLLFFLWEAESHAA--SRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLA 59
Query: 63 REGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLA 122
GV+LTQH++A+ LC+PSR+AF+TGRYP+RSGM S V A GLP +E T A
Sbjct: 60 SGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFA 119
Query: 123 ALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTE 182
LLK QGYST LIGKWH G++C S++D CHHP ++GF+Y+YG+ T + C P
Sbjct: 120 KLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFT 179
Query: 183 LAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILF--IFLLGYAWFSSHTSP 240
F+ ++L +Q+V + +LTL G + VP + FS++ + L + F + P
Sbjct: 180 TGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRP 239
Query: 241 LYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTD 300
L +C +MR +EI +QPM + + EA F++R+++ FLL S+LHVHT L ++
Sbjct: 240 L--NCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSK 297
Query: 301 DFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQL- 359
DF G S+HG+YGD VEEMD VG+IL+ +D+ L N+TL+YFTSD G H+E ++
Sbjct: 298 DFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIH 357
Query: 360 GGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLP 419
GG NGIYKGGK WEGGIRVPGI+RWP + AG+ I EPTS MDI PTVA ++G LP
Sbjct: 358 GGSNGIYKGGKA-NNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLP 416
Query: 420 QDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQP 479
+DR+IDGRDLMPLL+G + S+HEFLFHYC +YL+AVRW P+ +S S+WKA + TP F P
Sbjct: 417 EDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQ-NSTSIWKAFFFTPNFNP 475
Query: 480 PASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALK 539
S GC+ T +C CFG VT+H+PPLLFD+S+DP E PLTPA+EP ++K + A
Sbjct: 476 VGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAAD 535
Query: 540 EHQETIVPVTYQLSELN-QGRTWLKPCC-GVFPFCLCDKEEE 579
H +T+ V Q S N + WL+ CC C CD+E++
Sbjct: 536 RHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQ 577
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 362 bits (930), Expect = e-100
Identities = 175/319 (54%), Positives = 221/319 (69%)
Query: 4 RRPLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAR 63
R L + +C LL TC+ + KPNI+LIM DDLG GDLGCYGN+T+RTP+ID+LA
Sbjct: 15 RDSLPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAE 74
Query: 64 EGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAA 123
EGVRLTQH++AA LC+PSR+AFLTGR+ RSGM +S R +Q A GLP NETT A
Sbjct: 75 EGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFAR 134
Query: 124 LLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRNTEL 183
+L++ GY+TGLIGKWHQG+NC SR D CHHP N+GFDY+YGMPFTL + C P +
Sbjct: 135 ILQQHGYATGLIGKWHQGVNCASRGDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDA 194
Query: 184 AFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYW 243
A +QLW Q +A+ ILTL G+ G+ SV + M L +W+SS W
Sbjct: 195 ALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRW 254
Query: 244 DCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFT 303
+C+LMR H++TEQPM E+ S+M+KEA+S++ERH FLLF S LHVH PL TT F
Sbjct: 255 NCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFL 314
Query: 304 GTSKHGLYGDNVEEMDSMV 322
G S+HGLYGDNVEEMD ++
Sbjct: 315 GKSQHGLYGDNVEEMDWLI 333
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 219 bits (557), Expect = 7e-57
Identities = 175/543 (32%), Positives = 253/543 (46%), Gaps = 80/543 (14%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
PNIVLI DDLG GDLGCYG+ + TP++D+LA G+R T SLC+PSR+A LTGR
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 90 YPIRSGMVSSGNRRVIQNLAVPA---GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDS 146
P+R GM + VP+ GLPL E T+A +L +GY TG+ GKWH G+ +
Sbjct: 81 LPVRMGMYPG--------VLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
Query: 147 RSDQCHHPYN--YGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLT 204
H ++ G Y + +C+P P+ + + L V I +L
Sbjct: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP-PATPCDGGCDQGL------VPIPLLA-- 183
Query: 205 FGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAG 264
LS PWL F H++ + +R
Sbjct: 184 --NLSVEAQPPWLPGLEARYMAF----------------------AHDLMADAQRQDRP- 218
Query: 265 SIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
F L+++ H H P + F S G +GD++ E+D+ VG
Sbjct: 219 ------------------FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGT 260
Query: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
++ AI D GL TLV FT+D+G E R GG +G+ + GKG +EGG+R P +
Sbjct: 261 LMTAIGDLGLLEETLVIFTADNGP--ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPAL 315
Query: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEF 444
WPG + G + E S +D+LPT+A+++G LP + +DG DL PLL G + S +
Sbjct: 316 AFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQS 372
Query: 445 LFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPP 504
LF Y SY VR + +G +KAH+ T Q A C +T H PP
Sbjct: 373 LFFY-PSYPDEVRGVFAVRTGK-YKAHFFT---QGSAHSDTTADPACHA-SSSLTAHEPP 426
Query: 505 LLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGR-TWLK 563
LL+DLS+DP E+ L V++ + + VT+ S++ +G L+
Sbjct: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 486
Query: 564 PCC 566
CC
Sbjct: 487 ICC 489
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 219 bits (557), Expect = 7e-57
Identities = 175/543 (32%), Positives = 253/543 (46%), Gaps = 80/543 (14%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
PNIVLI DDLG GDLGCYG+ + TP++D+LA G+R T SLC+PSR+A LTGR
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 90 YPIRSGMVSSGNRRVIQNLAVPA---GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDS 146
P+R GM + VP+ GLPL E T+A +L +GY TG+ GKWH G+ +
Sbjct: 81 LPVRMGMYPG--------VLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
Query: 147 RSDQCHHPYN--YGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLT 204
H ++ G Y + +C+P P+ + + L V I +L
Sbjct: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP-PATPCDGGCDQGL------VPIPLLA-- 183
Query: 205 FGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAG 264
LS PWL F H++ + +R
Sbjct: 184 --NLSVEAQPPWLPGLEARYMAF----------------------AHDLMADAQRQDRP- 218
Query: 265 SIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
F L+++ H H P + F S G +GD++ E+D+ VG
Sbjct: 219 ------------------FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGT 260
Query: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
++ AI D GL TLV FT+D+G E R GG +G+ + GKG +EGG+R P +
Sbjct: 261 LMTAIGDLGLLEETLVIFTADNGP--ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPAL 315
Query: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEF 444
WPG + G + E S +D+LPT+A+++G LP + +DG DL PLL G + S +
Sbjct: 316 AFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQS 372
Query: 445 LFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPP 504
LF Y SY VR + +G +KAH+ T Q A C +T H PP
Sbjct: 373 LFFY-PSYPDEVRGVFAVRTGK-YKAHFFT---QGSAHSDTTADPACHA-SSSLTAHEPP 426
Query: 505 LLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGR-TWLK 563
LL+DLS+DP E+ L V++ + + VT+ S++ +G L+
Sbjct: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 486
Query: 564 PCC 566
CC
Sbjct: 487 ICC 489
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 219 bits (557), Expect = 7e-57
Identities = 175/543 (32%), Positives = 253/543 (46%), Gaps = 80/543 (14%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
PNIVLI DDLG GDLGCYG+ + TP++D+LA G+R T SLC+PSR+A LTGR
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 90 YPIRSGMVSSGNRRVIQNLAVPA---GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDS 146
P+R GM + VP+ GLPL E T+A +L +GY TG+ GKWH G+ +
Sbjct: 81 LPVRMGMYPG--------VLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
Query: 147 RSDQCHHPYN--YGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLT 204
H ++ G Y + +C+P P+ + + L V I +L
Sbjct: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP-PATPCDGGCDQGL------VPIPLLA-- 183
Query: 205 FGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAG 264
LS PWL F H++ + +R
Sbjct: 184 --NLSVEAQPPWLPGLEARYMAF----------------------AHDLMADAQRQDRP- 218
Query: 265 SIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
F L+++ H H P + F S G +GD++ E+D+ VG
Sbjct: 219 ------------------FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGT 260
Query: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
++ AI D GL TLV FT+D+G E R GG +G+ + GKG +EGG+R P +
Sbjct: 261 LMTAIGDLGLLEETLVIFTADNGP--ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPAL 315
Query: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEF 444
WPG + G + E S +D+LPT+A+++G LP + +DG DL PLL G + S +
Sbjct: 316 AFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQS 372
Query: 445 LFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPP 504
LF Y SY VR + +G +KAH+ T Q A C +T H PP
Sbjct: 373 LFFY-PSYPDEVRGVFAVRTGK-YKAHFFT---QGSAHSDTTADPACHA-SSSLTAHEPP 426
Query: 505 LLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGR-TWLK 563
LL+DLS+DP E+ L V++ + + VT+ S++ +G L+
Sbjct: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 486
Query: 564 PCC 566
CC
Sbjct: 487 ICC 489
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 219 bits (557), Expect = 7e-57
Identities = 175/543 (32%), Positives = 253/543 (46%), Gaps = 80/543 (14%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
PNIVLI DDLG GDLGCYG+ + TP++D+LA G+R T SLC+PSR+A LTGR
Sbjct: 21 PNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCTPSRAALLTGR 80
Query: 90 YPIRSGMVSSGNRRVIQNLAVPA---GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDS 146
P+R GM + VP+ GLPL E T+A +L +GY TG+ GKWH G+ +
Sbjct: 81 LPVRMGMYPG--------VLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEG 132
Query: 147 RSDQCHHPYN--YGFDYYYGMPFTLVDSCWPDPSRNTELAFESQLWLCVQLVAIAILTLT 204
H ++ G Y + +C+P P+ + + L V I +L
Sbjct: 133 AFLPPHQGFHRFLGIPYSHDQGPCQNLTCFP-PATPCDGGCDQGL------VPIPLLA-- 183
Query: 205 FGKLSGWVSVPWLLIFSMILFIFLLGYAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAG 264
LS PWL F H++ + +R
Sbjct: 184 --NLSVEAQPPWLPGLEARYMAF----------------------AHDLMADAQRQDRP- 218
Query: 265 SIMVKEAISFLERHSKETFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
F L+++ H H P + F S G +GD++ E+D+ VG
Sbjct: 219 ------------------FFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGT 260
Query: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
++ AI D GL TLV FT+D+G E R GG +G+ + GKG +EGG+R P +
Sbjct: 261 LMTAIGDLGLLEETLVIFTADNGP--ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPAL 315
Query: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEF 444
WPG + G + E S +D+LPT+A+++G LP + +DG DL PLL G + S +
Sbjct: 316 AFWPGHIAPG-VTHELASSLDLLPTLAALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQS 372
Query: 445 LFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPP 504
LF Y SY VR + +G +KAH+ T Q A C +T H PP
Sbjct: 373 LFFY-PSYPDEVRGVFAVRTGK-YKAHFFT---QGSAHSDTTADPACHA-SSSLTAHEPP 426
Query: 505 LLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSELNQGR-TWLK 563
LL+DLS+DP E+ L V++ + + VT+ S++ +G L+
Sbjct: 427 LLYDLSKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQ 486
Query: 564 PCC 566
CC
Sbjct: 487 ICC 489
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 153 bits (386), Expect = 5e-37
Identities = 109/324 (33%), Positives = 168/324 (51%), Gaps = 31/324 (9%)
Query: 266 IMVKEAISFLERHSKE-TFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
I ++EA+ F++R ++ F L+++ H P+ + F GTS+ G YGD V E+D +GK
Sbjct: 208 IYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGK 267
Query: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
IL+ + D + +NT V+FTSD+G L + + GG NG + GK +EGG+R P +
Sbjct: 268 ILELLQDLHVADNTFVFFTSDNGAALISA---PEQGGSNGPFLCGK-QTTFEGGMREPAL 323
Query: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMP-LLQGNVRHSEHE 443
WPG V AG++ + S+MD+ T +++G + P DR IDG +L+P LLQG +
Sbjct: 324 AWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRP-- 381
Query: 444 FLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQ---VTY 500
+F+Y G L A + KAH+ T S + + C G+ VT
Sbjct: 382 -IFYYRGDTLMAA-------TLGQHKAHFWTWT----NSWENFRQGIDFCPGQNVSGVTT 429
Query: 501 HN------PPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSE 554
HN PL+F L RDP E PL+ A+ + + ++ + +++HQE +VP QL+
Sbjct: 430 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQE-ALSRITSVVQQHQEALVPAQPQLNV 488
Query: 555 LNQG-RTWLKPCCGVFPFCLCDKE 577
N W P C CL E
Sbjct: 489 CNWAVMNWAPPGCEKLGKCLTPPE 512
Score = 117 bits (293), Expect = 3e-26
Identities = 60/139 (43%), Positives = 83/139 (59%), Gaps = 8/139 (5%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
PNI+L+++DD+G GDLG YG + TP++DR+A EG+ SA LCSPSR+A LTGR
Sbjct: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
Query: 90 YPIRSGMVSSG--NRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSR 147
PIR+G ++ R + G+P +E L LLKK GY + ++GKWH G
Sbjct: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ-- 148
Query: 148 SDQCHHPYNYGFDYYYGMP 166
HP +GFD ++G P
Sbjct: 149 ----FHPLKHGFDEWFGSP 163
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 145 bits (365), Expect = 1e-34
Identities = 133/457 (29%), Positives = 200/457 (43%), Gaps = 69/457 (15%)
Query: 113 GLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYN--YGFDYYYGMPFTLV 170
GLPL E T+A +L +GY TG+ GKWH G+ + H ++ G Y +
Sbjct: 15 GLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQN 74
Query: 171 DSCWPDPSRNTELAFESQLWLCVQLVAIAILTLTFGKLSGWVSVPWLLIFSMILFIFLLG 230
+C+P P+ + + L V I +L LS PWL F
Sbjct: 75 LTCFP-PATPCDGGCDQGL------VPIPLLA----NLSVEAQPPWLPGLEARYMAF--- 120
Query: 231 YAWFSSHTSPLYWDCLLMRGHEITEQPMKAERAGSIMVKEAISFLERHSKETFLLFFSFL 290
H++ + +R F L+++
Sbjct: 121 -------------------AHDLMADAQRQDRP-------------------FFLYYASH 142
Query: 291 HVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHL 350
H H P + F S G +GD++ E+D+ VG ++ AI D GL TLV FT+D+G
Sbjct: 143 HTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP-- 200
Query: 351 EARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTV 410
E R GG +G+ + GKG +EGG+R P + WPG + G + E S +D+LPT+
Sbjct: 201 ETMR--MSRGGCSGLLRCGKGT-TYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTL 256
Query: 411 ASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVRWIPKDDSGSVWKA 470
A+++G LP + +DG DL PLL G + S + LF Y SY VR + +G +KA
Sbjct: 257 AALAGAPLP-NVTLDGFDLSPLLLGTGK-SPRQSLFFY-PSYPDEVRGVFAVRTGK-YKA 312
Query: 471 HYVTPVFQPPASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFV 530
H+ T Q A C +T H PPLL+DLS+DP E+ L V
Sbjct: 313 HFFT---QGSAHSDTTADPACHA-SSSLTAHEPPLLYDLSKDPGENYNLLGGVAGATPEV 368
Query: 531 IKKVANALKEHQETIVPVTYQLSELNQGR-TWLKPCC 566
++ + + VT+ S++ +G L+ CC
Sbjct: 369 LQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICC 405
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 134 bits (338), Expect = 2e-31
Identities = 73/174 (41%), Positives = 103/174 (59%), Gaps = 16/174 (9%)
Query: 9 FMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRL 68
F + L++ C + + KPN V+I+ DD+G GDLG +T T ++D++A EG+R
Sbjct: 15 FSGFLYPLVDFCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRF 74
Query: 69 TQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPA--GLPLNETTLAALLK 126
+AAS CSPSR++ LTGR +R+G V +N AV + GLPLNETTLA +L+
Sbjct: 75 VDFHAAASTCSPSRASLLTGRLGLRNG--------VTRNFAVTSVGGLPLNETTLAEVLQ 126
Query: 127 KQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYGMPFTLVDSCWPDPSRN 180
+ GY TG+IGKWH G +HP GFDYY+G+P++ C P N
Sbjct: 127 QAGYVTGIIGKWHLG------HHGSYHPNFRGFDYYFGIPYSHDMGCTDTPGYN 174
Score = 125 bits (314), Expect = 1e-28
Identities = 100/336 (29%), Positives = 150/336 (44%), Gaps = 36/336 (10%)
Query: 253 ITEQPMKAERAGSIMVKEAISFLERHSKE--TFLLFFSFLHVHTPLPTTDDFTGTSKHGL 310
I EQP+ ++A F++R S FLL+ + H+H PLP T L
Sbjct: 209 IVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAPRGRSL 268
Query: 311 YGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGK 370
YG + EMDS+VG+I D +D ++ NT ++FT D+G + +G + G ++ +
Sbjct: 269 YGAGLWEMDSLVGQIKDKVDHT-VKENTFLWFTGDNGPWAQKCELAGSVGPFTGFWQTRQ 327
Query: 371 G-----MGGWEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVID 425
G WEGG RVP + WPG+VP S++DI PTV +++ SLPQ R D
Sbjct: 328 GGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQASLPQGRRFD 387
Query: 426 GRDLMPLLQGNVRHSEHEFLFH----YCGSY--LHAVRWIPKDDSGSVWKAHYVTPVFQP 479
G D+ +L G + H LFH G + L VR +KA Y+T
Sbjct: 388 GVDVSEVLFGRSQPG-HRVLFHPNSGAAGEFGALQTVRL-------ERYKAFYIT----- 434
Query: 480 PASGGCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALK 539
GG C H PL+F+L D +E+ PL + V+ +V L
Sbjct: 435 ---GG---ARACDGSTGPELQHKFPLIFNLEDDTAEAVPLERGGAE-YQAVLPEVRKVLA 487
Query: 540 EHQETIVPVTYQLSELNQGRTWLKPCCGVFPF-CLC 574
+ + I ++ Q + + PCC + C C
Sbjct: 488 DVLQDIANDNISSADYTQDPS-VTPCCNPYQIACRC 522
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/165 (39%), Positives = 93/165 (56%), Gaps = 15/165 (9%)
Query: 3 PRR---PLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHID 59
PRR P+V L+ LL + P++V ++ DDLG D+G +G+ +RTPH+D
Sbjct: 15 PRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLD 73
Query: 60 RLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET 119
LA GV L + + LC+PSRS LTGRY IR+G+ + I P+ +PL+E
Sbjct: 74 ALAAGGVLLDNYYTQP-LCTPSRSQLLTGRYQIRTGL-----QHQIIWPCQPSCVPLDEK 127
Query: 120 TLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYG 164
L LLK+ GY+T ++GKWH G+ +C P GFD Y+G
Sbjct: 128 LLPQLLKEAGYTTHMVGKWHLGM----YRKEC-LPTRRGFDTYFG 167
Score = 69.3 bits (168), Expect = 9e-12
Identities = 63/219 (28%), Positives = 89/219 (40%), Gaps = 22/219 (10%)
Query: 225 FIFLLGYAWFSSHTSPLYWDCLLM-------RGHEITEQPMKAERAGSIMVKEAISFLER 277
F +LLG + SH D L + R E K + +I K AI+ +
Sbjct: 166 FGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITN 225
Query: 278 HSKETFL-LFFSFLHVHTPLPTTD------DFTGTSKHGLYGDNVEEMDSMVGKILDAID 330
H E L L+ + VH PL + DF Y V MD VG + A+
Sbjct: 226 HPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALK 285
Query: 331 DFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGK 390
GL NNT+ F++D+GG L G N G+ WEGG+R G V P
Sbjct: 286 SSGLWNNTVFIFSTDNGGQ--------TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
Query: 391 VPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDL 429
G +E + D LPT+ ++ G + +DG D+
Sbjct: 338 KQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 376
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/165 (39%), Positives = 93/165 (56%), Gaps = 15/165 (9%)
Query: 3 PRR---PLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHID 59
PRR P+V L+ LL + P++V ++ DDLG D+G +G+ +RTPH+D
Sbjct: 15 PRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLD 73
Query: 60 RLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET 119
LA GV L + + LC+PSRS LTGRY IR+G+ + I P+ +PL+E
Sbjct: 74 ALAAGGVLLDNYYTQP-LCTPSRSQLLTGRYQIRTGL-----QHQIIWPCQPSCVPLDEK 127
Query: 120 TLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYG 164
L LLK+ GY+T ++GKWH G+ +C P GFD Y+G
Sbjct: 128 LLPQLLKEAGYTTHMVGKWHLGM----YRKEC-LPTRRGFDTYFG 167
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/361 (24%), Positives = 139/361 (38%), Gaps = 47/361 (13%)
Query: 225 FIFLLGYAWFSSHTSPLYWDCLLM-------RGHEITEQPMKAERAGSIMVKEAISFLER 277
F +LLG + SH D L + R E K + +I K AI+ +
Sbjct: 166 FGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITN 225
Query: 278 HSKETFL-LFFSFLHVHTPLPTTD------DFTGTSKHGLYGDNVEEMDSMVGKILDAID 330
H E L L+ + VH PL + DF Y V MD VG + A+
Sbjct: 226 HPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALK 285
Query: 331 DFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGK 390
GL NNT+ F++D+GG L G N G+ WEGG+R G V P
Sbjct: 286 SSGLWNNTVFIFSTDNGGQ--------TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
Query: 391 VPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCG 450
G +E + D LPT+ ++ G + +DG D+ + E L +
Sbjct: 338 KQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDP 397
Query: 451 SYLHAV-----RWIP-KDDSGSVWKAHYVTPVFQPPASG-----------GCYVTSLCRC 493
+++ + P KDDS + + T V G G + +
Sbjct: 398 NFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQY 457
Query: 494 FGEQVTYHNPPL----LFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVT 549
++ +PP LFD+ RDP E L+ + ++ K+ + L+ + + VPV
Sbjct: 458 NVSEIPSSDPPTKTLWLFDIDRDPEERHDLSRE----YPHIVTKLLSRLQFYHKHSVPVY 513
Query: 550 Y 550
+
Sbjct: 514 F 514
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 94.0 bits (232), Expect = 4e-19
Identities = 53/136 (38%), Positives = 81/136 (59%), Gaps = 12/136 (8%)
Query: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
+P+++ I+ DD G D+G +G++ ++TP +D+LA EGV+L + +C+PSRS F+TG
Sbjct: 75 QPHLIFILADDQGFRDVGYHGSE-IKTPTLDKLAAEGVKLENYY-VQPICTPSRSQFITG 132
Query: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRS 148
+Y I +G+ S I P LPL+ TL LK+ GYST ++GKWH G
Sbjct: 133 KYQIHTGLQHS-----IIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLGF----YR 183
Query: 149 DQCHHPYNYGFDYYYG 164
+C P GFD ++G
Sbjct: 184 KEC-MPTRRGFDTFFG 198
Score = 73.6 bits (179), Expect = 5e-13
Identities = 72/289 (24%), Positives = 119/289 (41%), Gaps = 37/289 (12%)
Query: 285 LFFSFLHVHTPLPTTDDFTGTSKHGL------YGDNVEEMDSMVGKILDAIDDFGLRNNT 338
L+ ++ VH+PL + + + Y + +D + + A+ +G NN+
Sbjct: 261 LYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAMLSCLDEAINNVTLALKTYGFYNNS 320
Query: 339 LVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGKVPAGRLIK 398
++ ++SD+GG A GG N +G KG WEGGIR G V P G + K
Sbjct: 321 IIIYSSDNGGQPTA-------GGSNWPLRGSKGTY-WEGGIRAVGFVHSPLLKNKGTVCK 372
Query: 399 EPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCGSYLHAVR- 457
E + D PT+ S++ G + +D +DG D+ + +R + L + Y A
Sbjct: 373 ELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNG 432
Query: 458 --------WIPKDDSG---SVWKAHYVTPVFQ---PPASGGCYVTSLCRCFGEQVTYH-- 501
W S WK P + PP S + R E++T
Sbjct: 433 SWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPN--RWHNERITLSTG 490
Query: 502 NPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTY 550
LF+++ DP E L+ + ++KK+ L + +T VPV Y
Sbjct: 491 KSVWLFNITADPYERVDLSNR----YPGIVKKLLRRLSQFNKTAVPVRY 535
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 90.9 bits (224), Expect = 3e-18
Identities = 55/135 (40%), Positives = 78/135 (57%), Gaps = 12/135 (8%)
Query: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
P+I+ I+ DD G D+G +G+D + TP +DRLA +GV+L + +C+PSRS LTGR
Sbjct: 47 PHIIFILTDDQGYHDVGYHGSD-IETPTLDRLAAKGVKLENYY-IQPICTPSRSQLLTGR 104
Query: 90 YPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSRSD 149
Y I +G+ S I P LPL++ TL L++ GYST ++GKWH G
Sbjct: 105 YQIHTGLQHS-----IIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGF----YRK 155
Query: 150 QCHHPYNYGFDYYYG 164
+C P GFD + G
Sbjct: 156 EC-LPTRRGFDTFLG 169
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/307 (25%), Positives = 118/307 (38%), Gaps = 35/307 (11%)
Query: 266 IMVKEAISFLERHSKETFL-LFFSFLHVHTPLPTTDDFT------GTSKHGLYGDNVEEM 318
+ + A L HS + L L+ +F VHTPL + ++ G Y V M
Sbjct: 211 LYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCM 270
Query: 319 DSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGG 378
D V I A+ +G NN+++ F+SD+GG + GG N +G KG WEGG
Sbjct: 271 DEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS-------GGSNWPLRGRKGTY-WEGG 322
Query: 379 IRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVR 438
+R G V P R + + D PT+ ++GG+ +DG D+ P +
Sbjct: 323 VRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRA 382
Query: 439 HSEHEFLFHYCGSYLHAVRWIPKDDSG------------SVWKAHYVTPVFQ---PPASG 483
E L + Y HA + G WK P + PP +
Sbjct: 383 SPRTEILHNIDPLYNHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTL 442
Query: 484 GCYVTSLCRCFGEQVTYHNPPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQE 543
+ S + LF++S DP E L V++ + L E+
Sbjct: 443 ATFPGSWWN-LERMASVRQAVWLFNISADPYEREDLAGQRPD----VVRTLLARLAEYNR 497
Query: 544 TIVPVTY 550
T +PV Y
Sbjct: 498 TAIPVRY 504
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 75.9 bits (185), Expect = 1e-13
Identities = 54/158 (34%), Positives = 85/158 (53%), Gaps = 14/158 (8%)
Query: 7 LVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGV 66
LV S+ AL + QA+ D N++LI+VDDL LGCYG+ +R+P+ID+LA +
Sbjct: 15 LVLSSVCVALGSETQANST-TDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSL 72
Query: 67 RLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLK 126
+ ++C+PSR +FLTGR P + + + V AG N +T+ K
Sbjct: 73 LFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNS-----YWRVHAG---NFSTIPQYFK 124
Query: 127 KQGYSTGLIGK-WHQGLNCDSRSDQCHHPYNYGFDYYY 163
+ GY T +GK +H G++ + D PY++ F Y+
Sbjct: 125 ENGYVTMSVGKVFHPGISSNHTDDS---PYSWSFPPYH 159
Score = 43.5 bits (101), Expect = 5e-04
Identities = 18/37 (48%), Positives = 27/37 (72%)
Query: 311 YGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHG 347
Y +V +D+ VG++L A+DD L N+T++ FTSDHG
Sbjct: 300 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 75.9 bits (185), Expect = 1e-13
Identities = 54/158 (34%), Positives = 85/158 (53%), Gaps = 14/158 (8%)
Query: 7 LVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGV 66
LV S+ AL + QA+ D N++LI+VDDL LGCYG+ +R+P+ID+LA +
Sbjct: 15 LVLSSVCVALGSETQANST-TDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSL 72
Query: 67 RLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNETTLAALLK 126
+ ++C+PSR +FLTGR P + + + V AG N +T+ K
Sbjct: 73 LFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNS-----YWRVHAG---NFSTIPQYFK 124
Query: 127 KQGYSTGLIGK-WHQGLNCDSRSDQCHHPYNYGFDYYY 163
+ GY T +GK +H G++ + D PY++ F Y+
Sbjct: 125 ENGYVTMSVGKVFHPGISSNHTDDS---PYSWSFPPYH 159
Score = 43.9 bits (102), Expect = 4e-04
Identities = 33/120 (27%), Positives = 58/120 (48%), Gaps = 11/120 (9%)
Query: 311 YGDNVEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNG------ 364
Y +V +D+ VG++L A+DD L N+T++ FTSDHG L A+ ++
Sbjct: 300 YFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHGEWAKYSNFDVATHVPL 359
Query: 365 -IYKGGKGMGGWEGGIRV-PGIVRWPGK---VPAGRLIKEPTSLMDILPTVASVSGGSLP 419
Y G+ E G ++ P + + + GR + L+ + PT+A ++G +P
Sbjct: 360 IFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVP 419
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 60.5 bits (145), Expect = 4e-09
Identities = 45/132 (34%), Positives = 63/132 (47%), Gaps = 17/132 (12%)
Query: 14 CALL---NTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQ 70
CALL C+A N +L++ DD G + G Y N + TPH+D LAR +
Sbjct: 9 CALLLVLGLCRAR-----PRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRN 62
Query: 71 HISAASLCSPSRSAFLTGRYPIRSGMVS-SGNRRVIQNLAVPAGLPLNETTLAALLKKQG 129
++ S CSPSR++ LTG ++GM + + LPL LL + G
Sbjct: 63 AFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-------LLSQAG 115
Query: 130 YSTGLIGKWHQG 141
TG+IGK H G
Sbjct: 116 VRTGIIGKKHVG 127
Score = 37.0 bits (84), Expect = 0.051
Identities = 65/259 (25%), Positives = 96/259 (37%), Gaps = 60/259 (23%)
Query: 315 VEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGI-YKGGKGMG 373
V MD VG +L + D G+ N+TLV FTSD NGI + G+
Sbjct: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSD-----------------NGIPFPSGRTNL 285
Query: 374 GWEGGIRVPGIVRWPGKVPA-GRLIKEPTSLMDILPTVASVSGGSLPQDRV-------ID 425
W G P +V P G++ + SL+D+ PT+ P + +
Sbjct: 286 YWPGTAE-PLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
Query: 426 GRDLMPLLQGNV-------RHSEHEFLFHY-----CGSYLHAVRWIPKDDSGSVWKAHYV 473
GR L+P L+ S HE Y + V + + + YV
Sbjct: 345 GRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYV 404
Query: 474 TPVFQPPASGGCYVTSLCRCFGEQVT----------YHNPPLLFDLSRDPSESTPLTPAT 523
+P FQ L R Q T Y L+D SRDP E+ L AT
Sbjct: 405 SPTFQ---------DLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNL--AT 453
Query: 524 EPLHDFVIKKVANALKEHQ 542
+P +++ + + L + Q
Sbjct: 454 DPRFAQLLEMLRDQLAKWQ 472
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 57.4 bits (137), Expect = 4e-08
Identities = 60/209 (28%), Positives = 92/209 (44%), Gaps = 51/209 (24%)
Query: 317 EMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWE 376
E D+M+G+I+ A+ L T+V ++SDHG E H Q YK M +E
Sbjct: 285 ETDAMLGEIILALHQLDLLQKTIVIYSSDHG---ELAMEHRQ------FYK----MSMYE 331
Query: 377 GGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGN 436
VP ++ PG + AG + SL+DI PT+ ++G LPQ+ + G L+PL
Sbjct: 332 ASAHVPLLMMGPG-IKAGLQVSNVVSLVDIYPTMLDIAGIPLPQN--LSGYSLLPLSSET 388
Query: 437 VRHSEHE--------FLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVT 488
+ +EH+ L + G ++A ++ + + WK Y+ S G +
Sbjct: 389 FK-NEHKVKNLHPPWILSEFHGCNVNASTYMLRTNH---WK--YIA------YSDGASIL 436
Query: 489 SLCRCFGEQVTYHNPPLLFDLSRDPSEST 517
P LFDLS DP E T
Sbjct: 437 ---------------PQLFDLSSDPDELT 450
Score = 37.7 bits (86), Expect = 0.030
Identities = 35/138 (25%), Positives = 62/138 (44%), Gaps = 19/138 (13%)
Query: 7 LVFMSLVCALLNTCQAHRVHDDK------PNIVLIMVDDLGIGDLGCY-GNDTMRTPHID 59
L+++S+V AL A + + PN+VL++ D G L + G+ ++ P I+
Sbjct: 3 LLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFD-GRLTFHPGSQVVKLPFIN 61
Query: 60 RLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET 119
+ G + + +C PSR+A +G + + + S N GL N T
Sbjct: 62 FMKTRGTSFLNAYTNSPICCPSRAAMWSGLF---THLTESWNNF--------KGLDPNYT 110
Query: 120 TLAALLKKQGYSTGLIGK 137
T ++++ GY T GK
Sbjct: 111 TWMDVMERHGYRTQKFGK 128
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 50.1 bits (118), Expect = 6e-06
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D V ++ + + + G NT + +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP +R P P G ++ + +D+ PT+ ++G P D +DG+ ++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T + + G +C PSRS+ L
Sbjct: 42 RPNIILVLTDDQDV-ELGSLQVMNKTRKI-----MEHGGATFINAFVTTPMCCPSRSSML 95
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQGYSTGLIGKW 138
TG+Y + + V + N +N + P+ ++E T A L GY T GK+
Sbjct: 96 TGKY-VHNHNVYTNN----ENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 50.1 bits (118), Expect = 6e-06
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D V ++ + + + G NT + +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP +R P P G ++ + +D+ PT+ ++G P D +DG+ ++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T + + G +C PSRS+ L
Sbjct: 42 RPNIILVLTDDQDV-ELGSLQVMNKTRKI-----MEHGGATFINAFVTTPMCCPSRSSML 95
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQGYSTGLIGKW 138
TG+Y + + V + N +N + P+ ++E T A L GY T GK+
Sbjct: 96 TGKY-VHNHNVYTNN----ENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 50.1 bits (118), Expect = 6e-06
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D V ++ + + + G NT + +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP +R P P G ++ + +D+ PT+ ++G P D +DG+ ++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T + + G +C PSRS+ L
Sbjct: 42 RPNIILVLTDDQDV-ELGSLQVMNKTRKI-----MEHGGATFINAFVTTPMCCPSRSSML 95
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQGYSTGLIGKW 138
TG+Y + + V + N +N + P+ ++E T A L GY T GK+
Sbjct: 96 TGKY-VHNHNVYTNN----ENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 50.1 bits (118), Expect = 6e-06
Identities = 34/116 (29%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D V ++ + + + G NT + +T+DHG H+ G G+ K GK M ++
Sbjct: 289 VDDSVERLYNMLVETGELENTYIIYTADHGYHI----------GQFGLVK-GKSM-PYDF 336
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP +R P P G ++ + +D+ PT+ ++G P D +DG+ ++ LL
Sbjct: 337 DIRVPFFIRGPSVEP-GSIVPQIVLNIDLAPTILDIAGLDTPPD--VDGKSVLKLL 389
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/113 (29%), Positives = 53/113 (46%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T + + G +C PSRS+ L
Sbjct: 42 RPNIILVLTDDQDV-ELGSLQVMNKTRKI-----MEHGGATFINAFVTTPMCCPSRSSML 95
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQGYSTGLIGKW 138
TG+Y + + V + N +N + P+ ++E T A L GY T GK+
Sbjct: 96 TGKY-VHNHNVYTNN----ENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY 143
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D + I + + + G +NT + +T+DHG H+ G G+ K GK M +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEF 337
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP VR P V AG L +D+ PT+ ++G +P D +DG+ ++ LL
Sbjct: 338 DIRVPFYVRGP-NVEAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T R + + G +C PSRS+ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET-TLAALLKKQGYSTGLIGKW 138
TG+Y ++ +N + P+ +E+ T A L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNN-----ENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D + I + + + G +NT + +T+DHG H+ G G+ K GK M +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEF 337
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP VR P V AG L +D+ PT+ ++G +P D +DG+ ++ LL
Sbjct: 338 DIRVPFYVRGP-NVEAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T R + + G +C PSRS+ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET-TLAALLKKQGYSTGLIGKW 138
TG+Y ++ +N + P+ +E+ T A L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNN-----ENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 49.3 bits (116), Expect = 1e-05
Identities = 38/116 (32%), Positives = 60/116 (51%), Gaps = 15/116 (12%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEG 377
+D + I + + + G +NT + +T+DHG H+ G G+ K GK M +E
Sbjct: 290 VDDSMETIYNMLVETGELDNTYIVYTADHGYHI----------GQFGLVK-GKSM-PYEF 337
Query: 378 GIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLL 433
IRVP VR P V AG L +D+ PT+ ++G +P D +DG+ ++ LL
Sbjct: 338 DIRVPFYVRGP-NVEAGCLNPHIVLNIDLAPTILDIAGLDIPAD--MDGKSILKLL 390
Score = 42.7 bits (99), Expect = 0.001
Identities = 32/113 (28%), Positives = 51/113 (45%), Gaps = 14/113 (12%)
Query: 29 KPNIVLIMVDDLGIGDLGCYG--NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFL 86
+PNI+L++ DD + +LG N T R + + G +C PSRS+ L
Sbjct: 43 RPNIILVLTDDQDV-ELGSMQVMNKTRRI-----MEQGGAHFINAFVTTPMCCPSRSSIL 96
Query: 87 TGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET-TLAALLKKQGYSTGLIGKW 138
TG+Y ++ +N + P+ +E+ T A L GY T GK+
Sbjct: 97 TGKYVHNHNTYTNN-----ENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKY 144
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 46.6 bits (109), Expect = 6e-05
Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 20/121 (16%)
Query: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHG---GHLEARRGHAQLGGWNGIYKGGKGMGG 374
+D +V K++ ++ G NNT +++TSD+G G QL
Sbjct: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQL--------------- 343
Query: 375 WEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQ 434
+E I+VP +VR PG P + K + +D+ PT+ ++G L + + +DG L+P+L+
Sbjct: 344 YEFDIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILR 401
Query: 435 G 435
G
Sbjct: 402 G 402
Score = 41.6 bits (96), Expect = 0.002
Identities = 36/139 (25%), Positives = 59/139 (42%), Gaps = 11/139 (7%)
Query: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
+PN+VL++ DD G T + G+ + ++LC PSR++ LTG
Sbjct: 46 RPNVVLLLTDDQD----EVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
Query: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQ-GYSTGLIGKWHQGLNCDS 146
+YP +V N + N + + + E T A+L+ GY T GK+
Sbjct: 102 KYPHNHHVV---NNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPD 158
Query: 147 RSDQCHHPYNYGFDYYYGM 165
H P G+ Y+Y +
Sbjct: 159 AGGLEHVP--LGWSYWYAL 175
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/93 (30%), Positives = 48/93 (51%), Gaps = 9/93 (9%)
Query: 50 NDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLA 109
++ ++ P+ID+LA + + ++C+PSR +FLTGR P + + +
Sbjct: 19 DELVKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNS-----YWR 73
Query: 110 VPAGLPLNETTLAALLKKQGYSTGLIGK-WHQG 141
V AG N +T+ K+ GY T +GK +H G
Sbjct: 74 VHAG---NFSTIPQYFKENGYVTMSVGKVFHPG 103
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.140 0.453
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,191,591
Number of Sequences: 37866
Number of extensions: 1215008
Number of successful extensions: 2928
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 24
Number of HSP's successfully gapped in prelim test: 20
Number of HSP's that attempted gapping in prelim test: 2784
Number of HSP's gapped (non-prelim): 72
length of query: 590
length of database: 18,247,518
effective HSP length: 108
effective length of query: 482
effective length of database: 14,157,990
effective search space: 6824151180
effective search space used: 6824151180
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.