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Search of human proteins with 31621309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31621309 leucine rich repeat containing 6 [Homo sapiens] 943 0.0
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 94 2e-19
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 76 6e-14
gi|239752518 PREDICTED: similar to leucine rich repeat containin... 75 1e-13
gi|15529980 leucine rich repeat containing 46 [Homo sapiens] 72 1e-12
gi|157674358 leucine rich repeat containing 50 [Homo sapiens] 70 5e-12
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 69 7e-12
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 69 7e-12
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 69 7e-12
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 69 7e-12
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 67 5e-11
gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 fami... 66 6e-11
gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 65 1e-10
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 63 5e-10
gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 62 1e-09
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s... 62 1e-09
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa... 62 1e-09
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 60 4e-09
gi|239735605 leucine rich repeat containing 36 isoform 1 [Homo s... 58 2e-08
gi|31377705 centrosomal protein 97kDa [Homo sapiens] 58 2e-08
gi|4826651 hypothetical protein LOC755 [Homo sapiens] 57 3e-08
gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 famil... 54 3e-07
gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo... 54 4e-07
gi|61966709 leucine rich repeat containing 67 [Homo sapiens] 50 3e-06
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 48 2e-05
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 48 2e-05
gi|66472382 nischarin [Homo sapiens] 47 3e-05
gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear... 46 8e-05
gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear... 46 8e-05
gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32 fam... 46 8e-05
>gi|31621309 leucine rich repeat containing 6 [Homo sapiens]
Length = 466
Score = 943 bits (2437), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE 60
MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE
Sbjct: 1 MGWITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIE 60
Query: 61 NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120
NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL
Sbjct: 61 NVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120
Query: 121 MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR 180
MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR
Sbjct: 121 MGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKR 180
Query: 181 AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL 240
AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL
Sbjct: 181 AKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKL 240
Query: 241 DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN 300
DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN
Sbjct: 241 DNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEKLSEKKKKVKPPRTLITEDGKALN 300
Query: 301 VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP 360
VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP
Sbjct: 301 VNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVDVQPTYVRVMIKGKPFQLVLPAEVKP 360
Query: 361 DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP 420
DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP
Sbjct: 361 DSSSAKRSQTTGHLVICMPKVGEVITGGQRAFKSMKTTSDRSREQTNTRSKHMEKLEVDP 420
Query: 421 SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI 466
SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI
Sbjct: 421 SKHSFPDVTNIVQEKKHTPRRRPEPKIIPSEEDPTFEDNPEVPPLI 466
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 94.4 bits (233), Expect = 2e-19
Identities = 93/366 (25%), Positives = 167/366 (45%), Gaps = 41/366 (11%)
Query: 3 WITEDLIRRNAEHNDCVIFSLEELSLHQ---QEIERLEHIDKWCRDLKILYLQNNLIGKI 59
+ITE LI++ + ++ + LSL + ++ + +E+++K C L++L L NLIGKI
Sbjct: 82 YITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEK-CVKLEVLNLSYNLIGKI 140
Query: 60 ENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL---------------- 103
E + KL KL LNL+ N I KIE +E L KL+L N I +
Sbjct: 141 EKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNL 200
Query: 104 --SSIKNLQHNIHLK------ELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSER 155
+ I +LQ LK L L+ NP + HY +F + L L+ L+G+ + +R
Sbjct: 201 KGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDR 260
Query: 156 IKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWY--TD 213
+A + +S+ E + E++ + + + + Q + EE KN+DK + + +
Sbjct: 261 QEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQS 320
Query: 214 INATLSSLESKDHLQAPDTEE--HNTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQ 271
S L +K+ L T E +K E +L F+ F P + + + E
Sbjct: 321 CEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPS-EYAEID 379
Query: 272 RKKQEK----LSEKKKKVKPPRTLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYM 327
+ E S K+ + + I + +A+ + + + D L+++ ++L + +
Sbjct: 380 KAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDH----MNLRGHTPL 435
Query: 328 DTSLID 333
DT L D
Sbjct: 436 DTQLED 441
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 76.3 bits (186), Expect = 6e-14
Identities = 51/161 (31%), Positives = 79/161 (49%), Gaps = 1/161 (0%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
SL+ L LH +I ++E+I+ C +L++L L N + ++N++ L L LNL N I +
Sbjct: 179 SLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 237
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
+++ L L L+ N I S+ L + L ++ GNP A Y+ V+ + Q
Sbjct: 238 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 297
Query: 142 LKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAK 182
L+ LD K I ER A E + RE K LK K
Sbjct: 298 LRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKK 338
Score = 48.1 bits (113), Expect = 2e-05
Identities = 77/346 (22%), Positives = 145/346 (41%), Gaps = 29/346 (8%)
Query: 8 LIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKK 67
+++R++E +++S + LSL +Q++ I+ L++L Q+N I +I+N+S L+K
Sbjct: 80 ILQRSSEEK--ILYS-DRLSLERQKLTVCPIINGEDH-LRLLNFQHNFITRIQNISNLQK 135
Query: 68 LEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCAS 127
L L+L N IE+I L L L L N I ++S+++NL+ L L L GN
Sbjct: 136 LISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLK---SLDVLDLHGNQITK 192
Query: 128 FDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQI---REQEKDHCLKRAKLK 184
++ + L ++ + +L + ++ QI R+ + CL+ L
Sbjct: 193 IENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLS 252
Query: 185 EEAQRKHQEED--KNEDKRSNAGFDGR------WYT-DINATLSSLESKDHLQAPDTEEH 235
+ S+ FDG WY + + L D + + E
Sbjct: 253 FNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 312
Query: 236 NTKKLDNSEDDLEFWNKPCLFTPESRLETLRHMEKQRKKQEK------LSEKKKKVKPPR 289
L E++ + + E + T+ ++ +Q Q++ +E +K P+
Sbjct: 313 MASVLAKKEEEKKRESHKQSLLKEKKRLTINNVARQWDLQQQRVANIATNEDRKDSDSPQ 372
Query: 290 TLITEDGKALNVNEPKIDFSLKDNEKQIILDLAVYRYMDTSLIDVD 335
DG L+ P+ L + L+V +DT L++VD
Sbjct: 373 DPCQIDGSTLSA-FPEETGPLDSGLNNALQGLSV---IDTYLVEVD 414
>gi|239752518 PREDICTED: similar to leucine rich repeat containing
50, partial [Homo sapiens]
Length = 489
Score = 75.1 bits (183), Expect = 1e-13
Identities = 50/161 (31%), Positives = 79/161 (49%), Gaps = 1/161 (0%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L+ L LH +I ++E+I+ C +L++L L N + ++N++ L L LNL N I +
Sbjct: 4 NLDVLDLHGNQITKIENINHLC-ELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 62
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
+++ L L L+ N I S+ L + L ++ GNP A Y+ V+ + Q
Sbjct: 63 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 122
Query: 142 LKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAK 182
L+ LD K I ER A E + RE K LK K
Sbjct: 123 LRQLDMKRITEEERRMASVLAKKEEEKKRESHKQSLLKEKK 163
>gi|15529980 leucine rich repeat containing 46 [Homo sapiens]
Length = 321
Score = 72.0 bits (175), Expect = 1e-12
Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 17/202 (8%)
Query: 4 ITEDLIRR-------NAEHNDCVIFSLEELS---LHQQEIERLEHIDKWCRDLKILYLQN 53
ITE LI + + E ++ + +L+EL L ++ I + +++ ++L LYLQ
Sbjct: 17 ITEALITKRNLTFPEDGELSEKMFHTLDELQTVRLDREGITTIRNLEG-LQNLHSLYLQG 75
Query: 54 NLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNI 113
N I +IEN++ + L +L+LA N I ++ENL L LDL+ N I ++K +
Sbjct: 76 NKIQQIENLACIPSLRFLSLAGNQIRQVENLLDLPCLQFLDLSENLI---ETLKLDEFPQ 132
Query: 114 HLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQE 173
L L L GN C + D YRE V LP L LDG+ + I +D + + + E
Sbjct: 133 SLLILNLSGNSCTNQDGYRELVTEALPLLLDLDGQPV-VERWISDEEDEASSDEEFPELS 191
Query: 174 KDHCLKRAKLKEEAQR--KHQE 193
C +R LKE Q +H+E
Sbjct: 192 GPFCSERGFLKELEQELSRHRE 213
>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
Length = 725
Score = 69.7 bits (169), Expect = 5e-12
Identities = 59/220 (26%), Positives = 99/220 (45%), Gaps = 38/220 (17%)
Query: 26 LSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEN-- 83
L L I+++E+++ +L+ L+LQ NL+ KIEN+ L+KL+ LNL+ N I+ IEN
Sbjct: 134 LWLQSNGIQKIENLEAQT-ELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLS 192
Query: 84 -----------------------LEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL 120
L+ C L LDL+ N + + + L+ L+ L L
Sbjct: 193 CLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNL 252
Query: 121 MGNP-CASFDHYREFVVATLPQLKWLDGKEIEPSERIKA-----------LQDYSVIEPQ 168
MGNP +YR V L L +LD + + P +R A ++ E +
Sbjct: 253 MGNPVIRQIPNYRRTVTVRLKHLTYLDDRPVFPKDRACAEAWARGGYAAEKEERQQWESR 312
Query: 169 IREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDG 208
R++ D A +K+ A+ + ++ + E + DG
Sbjct: 313 ERKKITDSIEALAMIKQRAEERKRQRESQERGEMTSSDDG 352
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/115 (32%), Positives = 56/115 (48%), Gaps = 10/115 (8%)
Query: 49 LYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKN 108
LYL +IEN+ + L L L N I+KIENLE EL L L +N + ++ +++
Sbjct: 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEP 171
Query: 109 LQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLD--GKEIEPSERIKALQD 161
LQ L L L N + ++ ++ LP L L +E E I+ LQ+
Sbjct: 172 LQ---KLDALNLSNNYIKTIEN-----LSCLPVLNTLQMAHNHLETVEDIQHLQE 218
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 69.3 bits (168), Expect = 7e-12
Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L +L L IE++E ++ L L L N I IE + L LE L+L N I KI
Sbjct: 66 NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
++L+ +L L L N I + +I L+ L+ L L NP + + Y+ F+ A LP
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
L +LD + I+ + +A YS+ E ++ QE L +A+L+ E+AQR+ E+ K
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237
Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
T L+ D + A D+E +N L + LE + +
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284
Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
+ E L+ EK++ + + SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 69.3 bits (168), Expect = 7e-12
Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L +L L IE++E ++ L L L N I IE + L LE L+L N I KI
Sbjct: 66 NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
++L+ +L L L N I + +I L+ L+ L L NP + + Y+ F+ A LP
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
L +LD + I+ + +A YS+ E ++ QE L +A+L+ E+AQR+ E+ K
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237
Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
T L+ D + A D+E +N L + LE + +
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284
Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
+ E L+ EK++ + + SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 69.3 bits (168), Expect = 7e-12
Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L +L L IE++E ++ L L L N I IE + L LE L+L N I KI
Sbjct: 66 NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
++L+ +L L L N I + +I L+ L+ L L NP + + Y+ F+ A LP
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
L +LD + I+ + +A YS+ E ++ QE L +A+L+ E+AQR+ E+ K
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237
Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
T L+ D + A D+E +N L + LE + +
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284
Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
+ E L+ EK++ + + SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 69.3 bits (168), Expect = 7e-12
Identities = 75/263 (28%), Positives = 122/263 (46%), Gaps = 25/263 (9%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L +L L IE++E ++ L L L N I IE + L LE L+L N I KI
Sbjct: 66 NLRKLQLDNNIIEKIEGLENLAH-LVWLDLSFNNIETIEGLDTLVNLEDLSLFNNRISKI 124
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
++L+ +L L L N I + +I L+ L+ L L NP + + Y+ F+ A LP
Sbjct: 125 DSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRNPISEAEDYKMFICAYLPD 184
Query: 142 LKWLDGKEIEPSER--IKALQDYSVIEPQIREQEKDHCLKRAKLK-EEAQRKHQEEDKNE 198
L +LD + I+ + +A YS+ E ++ QE L +A+L+ E+AQR+ E+ K
Sbjct: 185 LMYLDYRRIDDHTKKLAEAKHQYSIDE--LKHQEN---LMQAQLEDEQAQREELEKHK-- 237
Query: 199 DKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLEFWNKPCLFTP 258
T L+ D + A D+E +N L + LE + +
Sbjct: 238 -------------TAFVEHLNGSFLFDSMYAEDSEGNNLSYLPGVGELLETYKDKFVIIC 284
Query: 259 ESRLE-TLRHMEKQRKKQEKLSE 280
+ E L+ EK++ + + SE
Sbjct: 285 VNIFEYGLKQQEKRKTELDTFSE 307
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 66.6 bits (161), Expect = 5e-11
Identities = 47/141 (33%), Positives = 75/141 (53%), Gaps = 2/141 (1%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L LSL +I + ++K +KIL L NN I I + LK L+ L+L+ N I +
Sbjct: 238 NLIHLSLANNKITTINGLNKL--PIKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSL 295
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
+ LE + L ++L N I EL I+ +++ L+ L L+ NP Y FV+ L +
Sbjct: 296 QGLENHDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLR 355
Query: 142 LKWLDGKEIEPSERIKALQDY 162
L LD K+I+ E++ A+ Y
Sbjct: 356 LTELDQKKIKVEEKVSAVNKY 376
Score = 37.0 bits (84), Expect = 0.038
Identities = 43/155 (27%), Positives = 66/155 (42%), Gaps = 11/155 (7%)
Query: 18 CVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNN 77
C L++L L +IE L + L++ QNNL N K L+ + + N
Sbjct: 146 CGYVHLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLT-TFFNFKPPKNLKKADFSHNQ 204
Query: 78 IEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVA 137
I +I +L L KL L N I E+S ++ + IHL L N + + + +
Sbjct: 205 ISEICDLSAYHALTKLILDGNEIEEISGLEMCNNLIHLS---LANNKITTINGLNKLPIK 261
Query: 138 TLPQLKWLDGKEIE---PSERIKALQDYSVIEPQI 169
L L +IE E +KALQ+ + QI
Sbjct: 262 IL----CLSNNQIEMITGLEDLKALQNLDLSHNQI 292
>gi|13569879 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member E isoform 1 [Homo sapiens]
Length = 268
Score = 66.2 bits (160), Expect = 6e-11
Identities = 57/239 (23%), Positives = 115/239 (48%), Gaps = 4/239 (1%)
Query: 11 RNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEY 70
RN + L+ EIE L K L + ++ + + ++ +++KL+KLE
Sbjct: 12 RNRSPEEVTELVLDNCLCVNGEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKLEL 71
Query: 71 L-NLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD 129
N+ +E + E C L L+L+ N I +LS+++ LQ+ +LK L L + +
Sbjct: 72 SDNIISGGLEVLA--EKCPNLTYLNLSGNKIKDLSTVEALQNLKNLKSLDLFNCEITNLE 129
Query: 130 HYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQR 189
YRE + L Q+ +LDG + E +E + ++ + E+E+++ + EE +
Sbjct: 130 DYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEENEAGPPEGYEEEEE 189
Query: 190 KHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLE 248
+ +EED++ED+ + + LS L K+ +Q + ++ ++ + E++ E
Sbjct: 190 EEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDDDYVEEGEEEEEEEE 247
>gi|5453880 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member A [Homo sapiens]
Length = 249
Score = 65.1 bits (157), Expect = 1e-10
Identities = 61/216 (28%), Positives = 100/216 (46%), Gaps = 23/216 (10%)
Query: 35 RLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK-IENL-EGCEELAK 92
+LE + +L+ L N + I N+ KL KL+ L L+ N + +E L E C L
Sbjct: 33 KLEGLTDEFEELEFLSTINVGLTSIANLPKLNKLKKLELSDNRVSGGLEVLAEKCPNLTH 92
Query: 93 LDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEP 152
L+L+ N I +LS+I+ L+ +LK L L + + YRE V LPQL +LDG + +
Sbjct: 93 LNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNDYRENVFKLLPQLTYLDGYDRDD 152
Query: 153 SERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYT 212
E + + V E+++D + E+AQ EED++E++
Sbjct: 153 KEAPDSDAEGYVEGLDDEEEDED----EEEYDEDAQVVEDEEDEDEEEEGEE-------- 200
Query: 213 DINATLSSLESKDHLQAPDTEEHNTKKLDNSEDDLE 248
E + D E +N ++D+ ED+ E
Sbjct: 201 ---------EDVSGEEEEDEEGYNDGEVDDEEDEEE 227
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 63.2 bits (152), Expect = 5e-10
Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 13/142 (9%)
Query: 24 EELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIEN 83
E++ L+ I ++E + + +K L L+ NLI IEN+ +L+ L L+L N I+KIEN
Sbjct: 79 EDVDLNHYRIGKIEGFEV-LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIEN 137
Query: 84 LEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLK 143
LE EL LD++ N + + + L LK+LFL+ N + ++ ++ L QL+
Sbjct: 138 LEALTELEILDISFNLLRNIEGVDKL---TRLKKLFLVNNKISKIEN-----LSNLHQLQ 189
Query: 144 WLDGKEIEPSERIKALQDYSVI 165
L+ S RI+A+++ +
Sbjct: 190 MLE----LGSNRIRAIENIDTL 207
Score = 58.5 bits (140), Expect = 1e-08
Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 10 RRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLE 69
R A N + +LE L L + +I +L+++D +L +L +Q+N + KIE + L L
Sbjct: 197 RIRAIENIDTLTNLESLFLGKNKITKLQNLDA-LTNLTVLSMQSNRLTKIEGLQNLVNLR 255
Query: 70 YLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD 129
L L+ N IE IE LE +L LD+ N + I+N+ H L+E ++ N S+
Sbjct: 256 ELYLSHNGIEVIEGLENNNKLTMLDIASN---RIKKIENISHLTELQEFWMNDNLLESWS 312
Query: 130 HYREFVVATLPQLKWLDGKEI--EPSERIKAL 159
E A + +L+ + +P R K +
Sbjct: 313 DLDELKGARSLETVYLERNPLQKDPQYRRKVM 344
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 1/125 (0%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L LS+ + ++E + +L+ LYL +N I IE + KL L++A N I+KI
Sbjct: 231 NLTVLSMQSNRLTKIEGLQNLV-NLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289
Query: 82 ENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQ 141
EN+ EL + + N + S + L+ L+ ++L NP YR V+ LP
Sbjct: 290 ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349
Query: 142 LKWLD 146
++ +D
Sbjct: 350 VRQID 354
Score = 57.8 bits (138), Expect = 2e-08
Identities = 48/159 (30%), Positives = 72/159 (45%), Gaps = 20/159 (12%)
Query: 23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIE 82
LE L + + +E +DK R LK L+L NN I KIEN+S L +L+ L L N I IE
Sbjct: 144 LEILDISFNLLRNIEGVDKLTR-LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIE 202
Query: 83 NLEGCEELAKLDLTVNFI-------------------GELSSIKNLQHNIHLKELFLMGN 123
N++ L L L N I L+ I+ LQ+ ++L+EL+L N
Sbjct: 203 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
+ T+ + K+IE + LQ++
Sbjct: 263 GIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEF 301
>gi|210147571 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 3 [Homo sapiens]
Length = 220
Score = 62.0 bits (149), Expect = 1e-09
Identities = 48/194 (24%), Positives = 100/194 (51%), Gaps = 4/194 (2%)
Query: 56 IGKIENVSKLKKLEYL-NLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIH 114
+ ++ +++KL+KLE N+ +E + E C L L+L+ N I +LS+++ LQ+ +
Sbjct: 9 LARLPSLNKLRKLELSDNIISGGLEVLA--EKCPNLTYLNLSGNKIKDLSTVEALQNLKN 66
Query: 115 LKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEK 174
LK L L + + YRE + L Q+ +LDG + E +E + ++ + E+E+
Sbjct: 67 LKSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEE 126
Query: 175 DHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEE 234
++ + EE + + +EED++ED+ + + LS L K+ +Q + ++
Sbjct: 127 ENEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDD 185
Query: 235 HNTKKLDNSEDDLE 248
++ + E++ E
Sbjct: 186 DYVEEGEEEEEEEE 199
>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 62.0 bits (149), Expect = 1e-09
Identities = 46/168 (27%), Positives = 79/168 (47%), Gaps = 7/168 (4%)
Query: 20 IFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIE 79
+ SL + L ++E I+ LK LYL N++ K+E + L L L+L N I+
Sbjct: 178 LISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235
Query: 80 KIENLEG-CEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVAT 138
+ + L L+L N + L + L+ L+ L L+ NPC YR+ +
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQ 295
Query: 139 LPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEE 186
+P L+ LD + E ER +A VI +++E+++ + L+ E
Sbjct: 296 MPYLERLDKEFYEEEERAEA----DVIRQRLKEEKEQEPEPQRDLEPE 339
>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 62.0 bits (149), Expect = 1e-09
Identities = 46/168 (27%), Positives = 79/168 (47%), Gaps = 7/168 (4%)
Query: 20 IFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIE 79
+ SL + L ++E I+ LK LYL N++ K+E + L L L+L N I+
Sbjct: 178 LISLHTVELRGNQLESTLGIN--LPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQID 235
Query: 80 KIENLEG-CEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVAT 138
+ + L L+L N + L + L+ L+ L L+ NPC YR+ +
Sbjct: 236 TLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQ 295
Query: 139 LPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEE 186
+P L+ LD + E ER +A VI +++E+++ + L+ E
Sbjct: 296 MPYLERLDKEFYEEEERAEA----DVIRQRLKEEKEQEPEPQRDLEPE 339
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 60.1 bits (144), Expect = 4e-09
Identities = 50/161 (31%), Positives = 76/161 (47%), Gaps = 34/161 (21%)
Query: 22 SLEELSLHQQEIERLEHIDK-WCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEK 80
+L ++LH I ++E ID W +L+ L L +N I +IE ++ L KL LNL+ N I K
Sbjct: 44 TLHAVNLHCNNISKIEAIDHIW--NLQHLDLSSNQISRIEGLNTLTKLCTLNLSCNLITK 101
Query: 81 IENLEGCEELAKLDLTVNFIGELSSI---KNLQHNIHLKEL------------------- 118
+E LE L +L+++ N I +LS + ++H + +L
Sbjct: 102 VEGLEELINLTRLNVSYNHIDDLSGLIPLHGIKHKLRYIDLHSNRIDSIHHLLQCMVGLH 161
Query: 119 FLMG---------NPCASFDHYREFVVATLPQLKWLDGKEI 150
FL NP YR ++ TLPQL+ LD K I
Sbjct: 162 FLTNLILEKDGDDNPVCRLPGYRAVILQTLPQLRILDCKNI 202
Score = 31.6 bits (70), Expect = 1.6
Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 4/80 (5%)
Query: 30 QQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEE 89
+ E+E E D C D + ++ L I +S L +NL NNI KIE ++
Sbjct: 11 EAEVEN-EDGDSSCGD--VCFMDKGL-QSISELSLDSTLHAVNLHCNNISKIEAIDHIWN 66
Query: 90 LAKLDLTVNFIGELSSIKNL 109
L LDL+ N I + + L
Sbjct: 67 LQHLDLSSNQISRIEGLNTL 86
>gi|239735605 leucine rich repeat containing 36 isoform 1 [Homo
sapiens]
Length = 754
Score = 58.2 bits (139), Expect = 2e-08
Identities = 66/230 (28%), Positives = 100/230 (43%), Gaps = 17/230 (7%)
Query: 24 EELSLHQQEIERLEHIDKWCRDL-KILYLQNNLIGKIENVS----KLKKLEYLNLALNNI 78
E+ L ++ I RL + +L + L LQ + GKI ++ K L L+L+ N I
Sbjct: 3 EQWELDEEGIRRLGALTLEQPELVESLSLQGSYAGKIHSIGDAFRNFKNLRSLDLSRNLI 62
Query: 79 EKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFD-HYREFVVA 137
++ ++ L L+L N I L + LQ LKEL L NP D YR F V
Sbjct: 63 TSLKGIQYLCSLQDLNLYYNNIPSLVEVSRLQPLPFLKELDLRLNPVVRKDTDYRLFAVY 122
Query: 138 TLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKN 197
TL L+ LD + + ER A +S + ++ L+ K E K+ ++
Sbjct: 123 TLQTLEKLDDRTVREGERKAAKLHFSQL-----GNSENFLLEVEKSSREKTMKNCVTGES 177
Query: 198 EDKRSNAGFDGRWYTDINATL----SSLESKDHLQAPDTEEHNTK--KLD 241
+ +A D R D N L + E KD L T+ + T+ KLD
Sbjct: 178 SASKVSANVDSRIEMDSNKGLFIPFPNREIKDSLSTSATQGNGTRDQKLD 227
>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
Length = 865
Score = 58.2 bits (139), Expect = 2e-08
Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 5/144 (3%)
Query: 23 LEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIE 82
L +LS+ + R+ + K L++L L +N IG +E + +L LE+LNLA NN++ +E
Sbjct: 60 LIQLSVANNRLVRMMGVAKLTL-LRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAME 118
Query: 83 NLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
+ C L LDL+ N I ++ + L + LK L L GN S ++ +L L
Sbjct: 119 QINSCTALQHLDLSDNNISQIGDLSKL---VSLKTLLLHGNIITSLRMAPAYLPRSLAIL 175
Query: 143 KWLDGKEIEPSERIKALQDYSVIE 166
L EI I L + +E
Sbjct: 176 S-LAENEIRDLNEISFLASLTELE 198
Score = 42.0 bits (97), Expect = 0.001
Identities = 28/79 (35%), Positives = 43/79 (54%), Gaps = 3/79 (3%)
Query: 45 DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELS 104
D+ L L N I K+EN+ K K+L L++A N + ++ + L L+L N IG +
Sbjct: 37 DIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVE 96
Query: 105 SIKNLQHNIHLKELFLMGN 123
+K L +HL+ L L GN
Sbjct: 97 GLKEL---VHLEWLNLAGN 112
>gi|4826651 hypothetical protein LOC755 [Homo sapiens]
Length = 256
Score = 57.4 bits (137), Expect = 3e-08
Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 7/148 (4%)
Query: 64 KLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFLMGN 123
++ LE + L++N+I +E + C+ L++L L N I L+ + L+ L+ L+L N
Sbjct: 38 EMPSLEVITLSVNSISTLEPVSRCQRLSELYLRRNRIPSLAELFYLKGLPRLRVLWLAEN 97
Query: 124 PC--ASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDH----- 176
PC S YR V+ TLP+L+ LD + + E +AL + I + H
Sbjct: 98 PCCGTSPHRYRMTVLRTLPRLQKLDNQAVTEEELSRALSEGEEITAAPEREGTGHGGPKL 157
Query: 177 CLKRAKLKEEAQRKHQEEDKNEDKRSNA 204
C + L A+ D E+ S A
Sbjct: 158 CCTLSSLSSAAETGRDPLDSEEEATSGA 185
>gi|5454088 acidic (leucine-rich) nuclear phosphoprotein 32 family,
member B [Homo sapiens]
Length = 251
Score = 53.9 bits (128), Expect = 3e-07
Identities = 45/163 (27%), Positives = 79/163 (48%), Gaps = 14/163 (8%)
Query: 45 DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNI--------EKIENLEGCEELAKLDLT 96
+L+ L L N + + N+ KL KL+ L L+ N I EK+ NL L+L+
Sbjct: 43 NLEFLSLINVGLISVSNLPKLPKLKKLELSENRIFGGLDMLAEKLPNL------THLNLS 96
Query: 97 VNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERI 156
N + ++S+++ L+ LK L L + + YRE V LPQL +LDG + E E
Sbjct: 97 GNKLKDISTLEPLKKLECLKSLDLFNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAP 156
Query: 157 KALQDYSVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNED 199
+ + ++ + ++E + E + +E+D++ED
Sbjct: 157 DSDAEVDGVDEEEEDEEGEDEEDEDDEDGEEEEFDEEDDEDED 199
>gi|50593002 small nuclear ribonucleoprotein polypeptide A' [Homo
sapiens]
Length = 255
Score = 53.5 bits (127), Expect = 4e-07
Identities = 44/159 (27%), Positives = 81/159 (50%), Gaps = 8/159 (5%)
Query: 4 ITEDLIRRNAEHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVS 63
+T +LI + A++ + V EL L +I +E++ + +N I K++
Sbjct: 4 LTAELIEQAAQYTNAV--RDRELDLRGYKIPVIENLGATLDQFDAIDFSDNEIRKLDGFP 61
Query: 64 KLKKLEYLNLALNNIEKIENLEGCEE----LAKLDLTVNFIGELSSIKNLQHNIHLKELF 119
L++L+ L + N I +I EG ++ L +L LT N + EL + L L L
Sbjct: 62 LLRRLKTLLVNNNRICRIG--EGLDQALPCLTELILTNNSLVELGDLDPLASLKSLTYLS 119
Query: 120 LMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKA 158
++ NP + HYR +V+ +PQ++ LD ++++ ER +A
Sbjct: 120 ILRNPVTNKKHYRLYVIYKVPQVRVLDFQKVKLKERQEA 158
>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
Length = 228
Score = 50.4 bits (119), Expect = 3e-06
Identities = 34/113 (30%), Positives = 58/113 (51%), Gaps = 8/113 (7%)
Query: 4 ITEDLIRRNA-------EHNDCVIFSLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLI 56
+T DLI RN+ E + + ++ + I+ +E + C++L +LYL +N I
Sbjct: 4 LTLDLIARNSNLKPRKEETISQCLKKITHINFSDKNIDAIEDLSL-CKNLSVLYLYDNCI 62
Query: 57 GKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNL 109
+I N++ L +L L N I IENL ++L KL L N+I + ++ L
Sbjct: 63 SQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGL 115
Score = 49.3 bits (116), Expect = 7e-06
Identities = 32/72 (44%), Positives = 43/72 (59%), Gaps = 1/72 (1%)
Query: 22 SLEELSLHQQEIERLEHIDKWCRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKI 81
+L L L+ I ++ +++ + +L LYLQNN I IEN+ LKKLE L L N I I
Sbjct: 51 NLSVLYLYDNCISQITNLN-YATNLTHLYLQNNCISCIENLRSLKKLEKLYLGGNYIAVI 109
Query: 82 ENLEGCEELAKL 93
E LEG EL +L
Sbjct: 110 EGLEGLGELREL 121
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/76 (35%), Positives = 43/76 (56%), Gaps = 4/76 (5%)
Query: 58 KIENVSK-LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLK 116
K E +S+ LKK+ ++N + NI+ IE+L C+ L+ L L N I S I NL + +L
Sbjct: 19 KEETISQCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCI---SQITNLNYATNLT 75
Query: 117 ELFLMGNPCASFDHYR 132
L+L N + ++ R
Sbjct: 76 HLYLQNNCISCIENLR 91
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/105 (33%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 46 LKILYLQNNLIGKIENVSK--LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
L+ L+L +N I +E S L L+ + ++ N++ KI L L KLD++ N + +L
Sbjct: 1037 LRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDL 1096
Query: 104 -SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDG 147
S+IK L EL L GNP ++R+ ++ LP L+ L+G
Sbjct: 1097 KSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNG 1141
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/99 (25%), Positives = 52/99 (52%), Gaps = 3/99 (3%)
Query: 44 RDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
++L+ L L +N + + + + YL+ + N++ +E +E C L L L N++ EL
Sbjct: 969 KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028
Query: 104 SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
S++NL + L+EL L N ++ + + + + L +
Sbjct: 1029 PSLENL---VLLRELHLDDNSISTVEAFSSYWLPLLQNI 1064
Score = 34.7 bits (78), Expect = 0.19
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 43 CRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGE 102
C +L+ L L+ + + ++S KKL+Y++ N+IE IE CE L L + + +
Sbjct: 817 CTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE----CENLENLCVVLLNKNQ 872
Query: 103 LSSIKNLQ--HNIHLKEL 118
L+S+ L NI EL
Sbjct: 873 LTSLHGLDGCTNIQCLEL 890
Score = 29.3 bits (64), Expect = 8.0
Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 10/137 (7%)
Query: 65 LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL-MGN 123
+K+ + L NI+K E + +EL K + ++ K QH +++ L L M
Sbjct: 211 MKQFKVEKKKLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE 263
Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKL 183
F +E +L LK + ++ + KA Y P I+EQ + K +
Sbjct: 264 ERTRFKDQQEKEKNSL--LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEW 321
Query: 184 KEEAQRKHQEEDKNEDK 200
KE+ + Q+E++N +
Sbjct: 322 KEKEAKIRQKEEENRKR 338
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 47.8 bits (112), Expect = 2e-05
Identities = 35/105 (33%), Positives = 57/105 (54%), Gaps = 3/105 (2%)
Query: 46 LKILYLQNNLIGKIENVSK--LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
L+ L+L +N I +E S L L+ + ++ N++ KI L L KLD++ N + +L
Sbjct: 1037 LRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDL 1096
Query: 104 -SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDG 147
S+IK L EL L GNP ++R+ ++ LP L+ L+G
Sbjct: 1097 KSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRILNG 1141
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/99 (25%), Positives = 52/99 (52%), Gaps = 3/99 (3%)
Query: 44 RDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGEL 103
++L+ L L +N + + + + YL+ + N++ +E +E C L L L N++ EL
Sbjct: 969 KNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQILKLQGNYLSEL 1028
Query: 104 SSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQL 142
S++NL + L+EL L N ++ + + + + L +
Sbjct: 1029 PSLENL---VLLRELHLDDNSISTVEAFSSYWLPLLQNI 1064
Score = 34.7 bits (78), Expect = 0.19
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 6/78 (7%)
Query: 43 CRDLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGE 102
C +L+ L L+ + + ++S KKL+Y++ N+IE IE CE L L + + +
Sbjct: 817 CTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE----CENLENLCVVLLNKNQ 872
Query: 103 LSSIKNLQ--HNIHLKEL 118
L+S+ L NI EL
Sbjct: 873 LTSLHGLDGCTNIQCLEL 890
Score = 29.3 bits (64), Expect = 8.0
Identities = 33/137 (24%), Positives = 60/137 (43%), Gaps = 10/137 (7%)
Query: 65 LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHLKELFL-MGN 123
+K+ + L NI+K E + +EL K + ++ K QH +++ L L M
Sbjct: 211 MKQFKVEKKKLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE 263
Query: 124 PCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKDHCLKRAKL 183
F +E +L LK + ++ + KA Y P I+EQ + K +
Sbjct: 264 ERTRFKDQQEKEKNSL--LKQQNNAAVKIQAKYKAFVAYQKYGPIIKEQIESKKRKAQEW 321
Query: 184 KEEAQRKHQEEDKNEDK 200
KE+ + Q+E++N +
Sbjct: 322 KEKEAKIRQKEEENRKR 338
>gi|66472382 nischarin [Homo sapiens]
Length = 1504
Score = 47.4 bits (111), Expect = 3e-05
Identities = 40/151 (26%), Positives = 73/151 (48%), Gaps = 13/151 (8%)
Query: 33 IERLEHIDKWCRDLKILYLQNNLIGKIENV-SKLKKLEYLNLALNNIEKIENLEGCEELA 91
++ L+H+ +L L L N + +E + +KL ++ LNLA N +E + L L
Sbjct: 325 VDNLQHL----YNLVHLDLSYNKLSSLEGLHTKLGNIKTLNLAGNLLESLSGLHKLYSLV 380
Query: 92 KLDLTVNFIGELSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLK---WLDG- 147
LDL N I ++ ++++ L+ + L+ NP + YR V+A + LD
Sbjct: 381 NLDLRDNRIEQMEEVRSIGSLPCLEHVSLLNNPLSIIPDYRTKVLAQFGERASEVCLDDT 440
Query: 148 ----KEIEPSERIKALQDYSVIEPQIREQEK 174
KE++ E +KA+Q ++ ++ EK
Sbjct: 441 VTTEKELDTVEVLKAIQKAKEVKSKLSNPEK 471
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%)
Query: 46 LKILYLQNNLIGKI-ENVSKLKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELS 104
L L L +N I +I E+V + K+E+L+L+ N + ++NL+ L LDL+ N +LS
Sbjct: 289 LTTLDLSHNSISEIDESVKLIPKIEFLDLSHNGLLVVDNLQHLYNLVHLDLSYN---KLS 345
Query: 105 SIKNLQHNI-HLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYS 163
S++ L + ++K L L GN S + + +L L D + IE E ++++
Sbjct: 346 SLEGLHTKLGNIKTLNLAGNLLESLSGLHK--LYSLVNLDLRDNR-IEQMEEVRSIGSLP 402
Query: 164 VIE 166
+E
Sbjct: 403 CLE 405
>gi|239756368 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 24/204 (11%)
Query: 45 DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENL--EGCEELAKLDLTVNFIGE 102
+L+ L L N + I N+ KL KL+ L+ N I N+ E L L+L+ + +
Sbjct: 63 NLEFLRLINVGLISISNLPKLPKLKKFVLSENRIFGGLNMSAEKLPNLTHLNLSGKKLKD 122
Query: 103 LSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
+S+++ L+ LK L L + + Y+E V LPQL LD + E E +
Sbjct: 123 ISTLEPLKKLECLKSLDLFNCEVINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQV 182
Query: 163 SVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLE 222
++ + ++E + E + +EED++ED + +
Sbjct: 183 DGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGD------------------D 224
Query: 223 SKDHLQAPDTEEHNTKKLDNSEDD 246
KD + +EE LD EDD
Sbjct: 225 DKDEV----SEEEEEFGLDKDEDD 244
>gi|239750893 PREDICTED: similar to acidic (leucine-rich) nuclear
phosphoprotein 32 family, member B [Homo sapiens]
Length = 272
Score = 45.8 bits (107), Expect = 8e-05
Identities = 51/204 (25%), Positives = 86/204 (42%), Gaps = 24/204 (11%)
Query: 45 DLKILYLQNNLIGKIENVSKLKKLEYLNLALNNIEKIENL--EGCEELAKLDLTVNFIGE 102
+L+ L L N + I N+ KL KL+ L+ N I N+ E L L+L+ + +
Sbjct: 63 NLEFLRLINVGLISISNLPKLPKLKKFVLSENRIFGGLNMSAEKLPNLTHLNLSGKKLKD 122
Query: 103 LSSIKNLQHNIHLKELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDY 162
+S+++ L+ LK L L + + Y+E V LPQL LD + E E +
Sbjct: 123 ISTLEPLKKLECLKSLDLFNCEVINLNDYQESVFKLLPQLTCLDTYDPEDQEAPDSDAQV 182
Query: 163 SVIEPQIREQEKDHCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLE 222
++ + ++E + E + +EED++ED + +
Sbjct: 183 DGVDKEEEDEEGEDEKDXENEDGEEEELDEEEDEDEDVEGD------------------D 224
Query: 223 SKDHLQAPDTEEHNTKKLDNSEDD 246
KD + +EE LD EDD
Sbjct: 225 DKDEV----SEEEEEFGLDKDEDD 244
>gi|210147569 acidic (leucine-rich) nuclear phosphoprotein 32
family, member E isoform 2 [Homo sapiens]
Length = 227
Score = 45.8 bits (107), Expect = 8e-05
Identities = 42/193 (21%), Positives = 88/193 (45%), Gaps = 19/193 (9%)
Query: 57 GKIENVSK-LKKLEYLNLALNNIEKIENLEGCEELAKLDLTVNFIGELSSIKNLQHNIHL 115
G+IE ++ K+LE+L++A + + L +L K +L +L
Sbjct: 32 GEIEGLNDTFKELEFLSMANVELSSLARLPSLNKLRKQNLK-----------------NL 74
Query: 116 KELFLMGNPCASFDHYREFVVATLPQLKWLDGKEIEPSERIKALQDYSVIEPQIREQEKD 175
K L L + + YRE + L Q+ +LDG + E +E + ++ + E+E++
Sbjct: 75 KSLDLFNCEITNLEDYRESIFELLQQITYLDGFDQEDNEAPDSEEEDDEDGDEDDEEEEE 134
Query: 176 HCLKRAKLKEEAQRKHQEEDKNEDKRSNAGFDGRWYTDINATLSSLESKDHLQAPDTEEH 235
+ + EE + + +EED++ED+ + + LS L K+ +Q + ++
Sbjct: 135 NEAGPPEGYEEEEEEEEEEDEDEDEDEDEAGSELGEGEEEVGLSYL-MKEEIQDEEDDDD 193
Query: 236 NTKKLDNSEDDLE 248
++ + E++ E
Sbjct: 194 YVEEGEEEEEEEE 206
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,668,495
Number of Sequences: 37866
Number of extensions: 895594
Number of successful extensions: 5595
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 311
Number of HSP's that attempted gapping in prelim test: 4426
Number of HSP's gapped (non-prelim): 1079
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.