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Search of human proteins with 31542939
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform
1 [Homo sapiens]
(266 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ... 530 e-151
gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform... 331 4e-91
gi|40254992 carbonic reductase 4 [Homo sapiens] 112 4e-25
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 97 1e-20
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 91 8e-19
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens] 87 1e-17
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens] 87 2e-17
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens] 86 4e-17
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 82 4e-16
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 80 1e-15
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 79 4e-15
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 78 7e-15
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 75 6e-14
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens] 74 1e-13
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 72 4e-13
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 72 5e-13
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 71 1e-12
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 70 2e-12
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 70 2e-12
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 70 2e-12
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 68 9e-12
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A... 67 2e-11
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens] 65 6e-11
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 65 6e-11
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 62 5e-10
gi|186928839 retinol dehydrogenase 12 [Homo sapiens] 62 7e-10
gi|22507405 short chain dehydrogenase/reductase family 9C, membe... 62 7e-10
gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens] 61 1e-09
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ... 61 1e-09
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 60 2e-09
>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
[Homo sapiens]
Length = 266
Score = 530 bits (1366), Expect = e-151
Identities = 266/266 (100%), Positives = 266/266 (100%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA 180
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA 180
Query: 181 ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG 240
ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG
Sbjct: 181 ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG 240
Query: 241 AIMKITTSKGIHFQDYDTTPFQAKTQ 266
AIMKITTSKGIHFQDYDTTPFQAKTQ
Sbjct: 241 AIMKITTSKGIHFQDYDTTPFQAKTQ 266
>gi|224922801 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 2
[Homo sapiens]
Length = 178
Score = 331 bits (849), Expect = 4e-91
Identities = 166/166 (100%), Positives = 166/166 (100%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF
Sbjct: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLF 60
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD
Sbjct: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLD 120
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA
Sbjct: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAA 166
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 112 bits (279), Expect = 4e-25
Identities = 75/245 (30%), Positives = 125/245 (51%), Gaps = 23/245 (9%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
KV V G ++GIGRA A+ + KG ++A++ NLE L L CDV
Sbjct: 3 KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-----LAFSCDV 57
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLG-----LD 120
A + +++TF ++ H GR++ LVN AG+N + +T ++VS + LG
Sbjct: 58 AKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKA 117
Query: 121 YMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNA 180
M +GG I+N+ S+ GL + Q VY ASK G+VGF+R ALA + +R+N
Sbjct: 118 AMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSR--ALAKEVARKKIRVNV 175
Query: 181 ICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNG 240
+ PGFV+T + + +++E H+K I + +A+ ++ L+E + G
Sbjct: 176 VAPGFVHTDMTKDLKEE-----------HLKKNIPLGRFGETIEVAHAVVFLLESPYITG 224
Query: 241 AIMKI 245
++ +
Sbjct: 225 HVLVV 229
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 97.1 bits (240), Expect = 1e-20
Identities = 65/199 (32%), Positives = 101/199 (50%), Gaps = 21/199 (10%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
GKV +VTG +GIG A + GA+V + D + G AL+++ +FI CD
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGG----RALEQELPG--AVFILCD 62
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAG---------VNNEKNWEKTLQINLVSVISGT 115
V + ++ + + FGRLD +VNNAG + + + + L++NL+ + T
Sbjct: 63 VTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122
Query: 116 YLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSG 175
L L Y+ K G +IN+SSL G + AQ Y A+K + T+ ALA + G
Sbjct: 123 KLALPYLRKSQGN----VINISSLVGAIGQAQAVPYVATKGAVTAMTK--ALALDESPYG 176
Query: 176 VRLNAICPGFVNTAILESI 194
VR+N I PG + T + E +
Sbjct: 177 VRVNCISPGNIWTPLWEEL 195
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 91.3 bits (225), Expect = 8e-19
Identities = 74/262 (28%), Positives = 121/262 (46%), Gaps = 35/262 (13%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
Query: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSA 165
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMT--L 180
Query: 166 ALAANLMNSGVRLNAICPGFVNTAILESI-EKEEN-MGQYIEYKDHIKDMIKYYGILDPP 223
+A +L G+R+ I PG T +L S+ EK N + + + + D +Y
Sbjct: 181 PIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEY------- 233
Query: 224 LIANGLITLIEDDALNGAIMKI 245
A+ + +IE+ LNG ++++
Sbjct: 234 --AHLVQAIIENPFLNGEVIRL 253
>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
Length = 245
Score = 87.4 bits (215), Expect = 1e-17
Identities = 72/204 (35%), Positives = 110/204 (53%), Gaps = 35/204 (17%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
++GKV ++T AAQGIG+A A A +GAKV D N E+ +Q E +K IQ
Sbjct: 4 LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDIN-ESKLQ---------ELEKYPGIQ 53
Query: 63 CDVADQQQLRDTFRKVVDHFG----RLDILVNNAGVNN--------EKNWEKTLQINLVS 110
V D T +K +D F RLD+L N AG + EK+W+ ++ +N+ S
Sbjct: 54 TRVLDV-----TKKKQIDQFANEVERLDVLFNVAGFVHHGTVLDCEEKDWDFSMNLNVRS 108
Query: 111 VISGTYLGLD-YMSKQNGGEGGIIINMSSLA-GLMPVAQQPVYCASKHGIVGFTRSAALA 168
+ YL + ++ K + G IINMSS+A + V + VY +K ++G T+S +A
Sbjct: 109 M----YLMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKS--VA 162
Query: 169 ANLMNSGVRLNAICPGFVNTAILE 192
A+ + G+R N +CPG V+T L+
Sbjct: 163 ADFIQQGIRCNCVCPGTVDTPSLQ 186
>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
Length = 300
Score = 86.7 bits (213), Expect = 2e-17
Identities = 71/228 (31%), Positives = 118/228 (51%), Gaps = 20/228 (8%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G++ L+TGA GIGR A +K+ L D N + G++ AA + + F+
Sbjct: 34 VTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDIN-KHGLEETAAKCKGLGAKVHTFV- 91
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114
D ++++ + + +KV G + ILVNNAGV + EKT ++N+++
Sbjct: 92 VDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEKTFEVNVLAHFWT 151
Query: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGF--TRSAALAANLM 172
T L M+K N G I+ ++S AG + V YC+SK VGF T + LAA L
Sbjct: 152 TKAFLPAMTKNNHGH---IVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA-LQ 207
Query: 173 NSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGIL 220
+GV+ +CP FVNT +++ ++G +E ++ + ++ +GIL
Sbjct: 208 ITGVKTTCLCPNFVNTGFIKN--PSTSLGPTLEPEEVVNRLM--HGIL 251
>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
Length = 261
Score = 85.5 bits (210), Expect = 4e-17
Identities = 75/258 (29%), Positives = 127/258 (49%), Gaps = 32/258 (12%)
Query: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAAL----DEQFEPQKT-LFI 61
+ALVTGA GIGRA + L +GA VA D + A + L ++ P+
Sbjct: 13 LALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAF 72
Query: 62 QCDVADQQQLRDTFRKVVDHFGRL-DILVNNAGVN--------NEKNWEKTLQINLVSVI 112
Q DV++ + R +V F R ++V+ AG+ +E +W+K + +NL
Sbjct: 73 QADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNL---- 128
Query: 113 SGTYLGLDYMSKQ--NGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
GT+L ++ + G G IIN+SS+ G + Q Y ASK G++G T++A A
Sbjct: 129 KGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTA--ARE 186
Query: 171 LMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLI 230
L G+R N++ PGF+ T + + + + + D I +MI + DP +A+ +
Sbjct: 187 LGRHGIRCNSVLPGFIATPMTQKVPQ--------KVVDKITEMIPMGHLGDPEDVADVVA 238
Query: 231 TLIEDDA--LNGAIMKIT 246
L +D+ + G +++T
Sbjct: 239 FLASEDSGYITGTSVEVT 256
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 82.4 bits (202), Expect = 4e-16
Identities = 65/213 (30%), Positives = 98/213 (46%), Gaps = 19/213 (8%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
+VA+VTG+ GIG A A L GA V + + + A L Q E I C V
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ K ++H G +D LV +AGVN +E+ W+K L +N+ S
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176
L YM + G +I +SS+A PV VY SK ++G TR+ LA L +
Sbjct: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRT--LALELAPKDI 208
Query: 177 RLNAICPGFVNTAILESIEKEENMGQYIEYKDH 209
R+N + PG + T + E++ + +K+H
Sbjct: 209 RVNCVVPGIIKTDFSKVFHGNESL--WKNFKEH 239
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 80.5 bits (197), Expect = 1e-15
Identities = 62/192 (32%), Positives = 89/192 (46%), Gaps = 17/192 (8%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
+VA+VTG+ GIG A A L GA V + + + A L Q E I C V
Sbjct: 37 RVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKL--QGEGLSVAGIVCHV 94
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ K ++H G +D LV +AGVN +E+ W+K L +N+ S
Sbjct: 95 GKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176
L YM + G +I +SS+A PV VY SK ++G TR+ LA L +
Sbjct: 155 QLLPYMENRRGA----VILVSSIAAYNPVVALGVYNVSKTALLGLTRT--LALELAPKDI 208
Query: 177 RLNAICPGFVNT 188
R+N + PG + T
Sbjct: 209 RVNCVVPGIIKT 220
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 79.0 bits (193), Expect = 4e-15
Identities = 66/215 (30%), Positives = 96/215 (44%), Gaps = 20/215 (9%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCDV 65
KVALVT + GIG A A L GA V + + Q A L Q E C V
Sbjct: 33 KVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTVCHV 90
Query: 66 ADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVISGTY 116
+ V G +DILV+NA VN E+ W+KTL IN+ + T
Sbjct: 91 GKAEDRERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGV 176
+ M K+ GG ++ +SS+A P Y SK ++G T++ LA L +
Sbjct: 151 AVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLTKT--LAIELAPRNI 205
Query: 177 RLNAICPGFVNTAILESI----EKEENMGQYIEYK 207
R+N + PG + T+ + EKEE+M + + +
Sbjct: 206 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR 240
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 78.2 bits (191), Expect = 7e-15
Identities = 58/197 (29%), Positives = 94/197 (47%), Gaps = 21/197 (10%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQK---TL 59
+ G+VA+VTG A GIG+A + LL G+ V + LE L P K +
Sbjct: 16 LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75
Query: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN--------NEKNWEKTLQINLVSV 111
IQC++ +++++ + + +D FG+++ LVNN G + K W L+ NL
Sbjct: 76 PIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGT 135
Query: 112 ISGTYLGLDYMSKQNGGEGGIIIN--MSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAA 169
Y+ S GG I+N + + AG P+A A++ G+ T+S LA
Sbjct: 136 F---YMCKAVYSSWMKEHGGSIVNIIVPTKAG-FPLAVHS--GAARAGVYNLTKS--LAL 187
Query: 170 NLMNSGVRLNAICPGFV 186
SG+R+N + PG +
Sbjct: 188 EWACSGIRINCVAPGVI 204
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 75.1 bits (183), Expect = 6e-14
Identities = 70/263 (26%), Positives = 114/263 (43%), Gaps = 46/263 (17%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G VA++TG A G+G A AE L+ +GA L+D G L +F
Sbjct: 8 VKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNN-----CVFAP 62
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------------NNEKNWEKTLQINL 108
DV ++ ++ FGR+D+ VN AG+ + +++++ L +NL
Sbjct: 63 ADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNL 122
Query: 109 VSVISGTYLGLDYMSKQN---GGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSA 165
+ + L M + GG+ G+IIN +S+A Q Y ASK GIVG T
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182
Query: 166 ALAANLMNSGVRLNAICP-GFVNTAILESI-EKEEN-MGQYIEYKDHIKDMIKYYGILDP 222
A + P G T +L S+ EK N + + + + D +Y
Sbjct: 183 A------------RDLAPIGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEY------ 224
Query: 223 PLIANGLITLIEDDALNGAIMKI 245
A+ + +IE+ LNG ++++
Sbjct: 225 ---AHLVQAIIENPFLNGEVIRL 244
>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
Length = 260
Score = 74.3 bits (181), Expect = 1e-13
Identities = 54/197 (27%), Positives = 97/197 (49%), Gaps = 19/197 (9%)
Query: 6 KVALVTGAAQGIGRAFAEALLLKGAKV---ALVDWNL-EAGVQCKAALDEQFEPQKTLFI 61
++ALVTGA+ GIG A A AL+ +G KV A N+ E +CK+A P +
Sbjct: 12 RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSA----GYPGTLIPY 67
Query: 62 QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVIS 113
+CD+++++ + F + +DI +NNAG+ + W+ +N++++
Sbjct: 68 RCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMFNVNVLALSI 127
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAG--LMPVAQQPVYCASKHGIVGFTRSAALAANL 171
T M ++N +G IIN++S++G ++P++ Y A+K+ + T
Sbjct: 128 CTREAYQSMKERNVDDGH-IININSMSGHRVLPLSVTHFYSATKYAVTALTEGLRQELRE 186
Query: 172 MNSGVRLNAICPGFVNT 188
+ +R I PG V T
Sbjct: 187 AQTHIRATCISPGVVET 203
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 72.4 bits (176), Expect = 4e-13
Identities = 57/198 (28%), Positives = 93/198 (46%), Gaps = 16/198 (8%)
Query: 7 VALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQ--FEPQKTLFIQCD 64
V VTGA+ GIG A L G + L + + K E + + L + D
Sbjct: 52 VVWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDILVLPLD 111
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEK--------NWEKTLQINLVSVISGTY 116
+ D + V+ FGR+DILVNN G++ + K +++N + +S T
Sbjct: 112 LTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLTK 171
Query: 117 LGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN-SG 175
L +M ++ G+ I+ ++S+ G++ V YCASKH + GF L L G
Sbjct: 172 CVLPHMIERKQGK---IVTVNSILGIISVPLSIGYCASKHALRGFFN--GLRTELATYPG 226
Query: 176 VRLNAICPGFVNTAILES 193
+ ++ ICPG V + I+E+
Sbjct: 227 IIVSNICPGPVQSNIVEN 244
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 72.0 bits (175), Expect = 5e-13
Identities = 66/229 (28%), Positives = 101/229 (44%), Gaps = 37/229 (16%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCK---------------A 47
V G+V L+TGA G+GR FA + A + L D N ++ + A
Sbjct: 34 VAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAA 93
Query: 48 AL-----DEQFEPQKTLFI---QCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNN--- 96
AL +E+ P L + CDV ++ + T +V G + +LVNNAGV +
Sbjct: 94 ALQAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHH 153
Query: 97 -----EKNWEKTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVY 151
++ E+T+ +N + T L M + N G I+ ++S GL A Y
Sbjct: 154 LLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHGH---IVTVASSLGLFSTAGVEDY 210
Query: 152 CASKHGIVGFTRSAALAANLM-NSGVRLNAICPGFVNTAILES--IEKE 197
CASK G+VGF S + G++ +CP V+T + I KE
Sbjct: 211 CASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKE 259
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 70.9 bits (172), Expect = 1e-12
Identities = 55/201 (27%), Positives = 91/201 (45%), Gaps = 15/201 (7%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
+V G++ L+TGA G+GR A G+ + L D N E + CK A + +
Sbjct: 37 NVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMA--REAGATRVHA 94
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
CD + ++ + +V G + IL+NNAG+ K + EK+ +N + +
Sbjct: 95 YTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHL 154
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLM 172
TY ++ + G ++ +SS AGL V YCASK GF S + +
Sbjct: 155 -WTYKA--FLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQ 211
Query: 173 -NSGVRLNAICPGFVNTAILE 192
G++ +CP F+ T + E
Sbjct: 212 KQKGIKTTIVCPFFIKTGMFE 232
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 70.1 bits (170), Expect = 2e-12
Identities = 61/200 (30%), Positives = 101/200 (50%), Gaps = 24/200 (12%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
G+ A+VTG+ GIG+++AE L G KV L+ + + Q + + E+F+ + T I D
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVE-TRTIAVD 108
Query: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAGVNNE------------KNWEKTLQINLVS 110
A + D + K+ L+ ILVNN G++ E +K + IN++S
Sbjct: 109 FASE----DIYDKIKTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILS 164
Query: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
V T L L M +++ G I+N+SS +G++PV +Y A+K + F S L
Sbjct: 165 VCKMTQLVLPGMVERS---KGAILNISSGSGMLPVPLLTIYSATKTFVDFF--SQCLHEE 219
Query: 171 LMNSGVRLNAICPGFVNTAI 190
+ GV + ++ P FV T +
Sbjct: 220 YRSKGVFVQSVLPYFVATKL 239
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 69.7 bits (169), Expect = 2e-12
Identities = 56/205 (27%), Positives = 96/205 (46%), Gaps = 16/205 (7%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQ-CKAALDEQFEPQKTLF 60
+V G++ L TGA G+GR A GA + L D N E ++ C+ A ++ +K
Sbjct: 33 NVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNMETCRLAKEK--GGKKVFP 90
Query: 61 IQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLVSVI 112
CD +++Q++ +V FG + ILVNNA + K + EK+ +N ++
Sbjct: 91 YTCDCSNRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFLDIPDHMVEKSFLVNAITHF 150
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQ----PVYCASKHGIVGFTRSAALA 168
L + K N G I +++ + G+ ++ + P Y ASK GF S
Sbjct: 151 WTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSPYYSASKFAAFGFAESLFFE 210
Query: 169 ANLM-NSGVRLNAICPGFVNTAILE 192
++ + V+ +CP F+NT + E
Sbjct: 211 LTMIKKTEVKSTIVCPHFINTGMFE 235
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 69.7 bits (169), Expect = 2e-12
Identities = 63/210 (30%), Positives = 94/210 (44%), Gaps = 30/210 (14%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
+ GK +VTGA GIG+ A L +G + L ++E +C+AA + +
Sbjct: 36 IPGKTVIVTGANTGIGKQTALELARRGGNIILACRDME---KCEAAAKDIRGETLNHHVN 92
Query: 63 C---DVADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVIS 113
D+A + +R+ K+++ R+DIL+NNAGV E +E +N +
Sbjct: 93 ARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFL 152
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGL-------------MPVAQQPVYCASKHGIVG 160
T L LD K IIN+SSLA + + YC SK IV
Sbjct: 153 LTNLLLD---KLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVL 209
Query: 161 FTRSAALAANLMNSGVRLNAICPGFVNTAI 190
FT+ L+ L SGV +NA+ PG T +
Sbjct: 210 FTKE--LSRRLQGSGVTVNALHPGVARTEL 237
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 67.8 bits (164), Expect = 9e-12
Identities = 56/196 (28%), Positives = 95/196 (48%), Gaps = 19/196 (9%)
Query: 1 MHVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVD--WNLEAGVQCKAALDEQFEPQKT 58
+ +G+V LVTGA G+GRA+A A +GA V + D + + + A D+ E +
Sbjct: 5 LRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRR 64
Query: 59 LFIQCDVADQQQLRD---TFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQIN 107
+ VA+ + + + +D FGR+D++VNNAG+ ++++W+ +++
Sbjct: 65 RGGKA-VANYDSVEEGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWDIIHRVH 123
Query: 108 LVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAAL 167
L T ++M KQ G II SS +G+ Q Y A+K G++G S A+
Sbjct: 124 LRGSFQVTRAAWEHMKKQKYGR---IIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAI 180
Query: 168 AANLMNSGVRLNAICP 183
S + N I P
Sbjct: 181 EGR--KSNIHCNTIAP 194
>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
[Homo sapiens]
Length = 300
Score = 67.0 bits (162), Expect = 2e-11
Identities = 55/201 (27%), Positives = 99/201 (49%), Gaps = 16/201 (7%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
V G++ L+TGA GIGR + + + L D N + GV+ AA + ++
Sbjct: 34 VAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDIN-KRGVEETAAECRKLGVTAHAYV- 91
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGV--------NNEKNWEKTLQINLVSVISG 114
D ++++++ + +V G + I+VNNAG ++ KT ++N++
Sbjct: 92 VDCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWI 151
Query: 115 TYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTR--SAALAANLM 172
T L M ++N G I+ ++S+ G + YC+SK VGF R ++ L A L
Sbjct: 152 TKALLPSMMERNHGH---IVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQA-LG 207
Query: 173 NSGVRLNAICPGFVNTAILES 193
+G++ + +CP FVNT ++
Sbjct: 208 KTGIKTSCLCPVFVNTGFTKN 228
>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
Length = 317
Score = 65.1 bits (157), Expect = 6e-11
Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 24/223 (10%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
H+ K +TG G G A L +G +V + Q + ++ E +
Sbjct: 26 HLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLET-----V 80
Query: 62 QCDVADQQQLRDTFRKVVDHFGRLDI--LVNNAGV---------NNEKNWEKTLQINLVS 110
DV + + + V +H G + LVNNAG+ N ++ L++NL+
Sbjct: 81 TLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIG 140
Query: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
VI T L + + G I+N+SS+ G + YC SK+G+ F S L
Sbjct: 141 VIQVTLSMLPLVRRARGR----IVNVSSILGRVAFFVGG-YCVSKYGVEAF--SDILRRE 193
Query: 171 LMNSGVRLNAICPGFVNTAILESIEKEENMGQ-YIEYKDHIKD 212
+ + GV+++ + PG+ T + + E M Q + E HIK+
Sbjct: 194 IQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKE 236
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 65.1 bits (157), Expect = 6e-11
Identities = 51/199 (25%), Positives = 91/199 (45%), Gaps = 17/199 (8%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWN---LEAGV-QCKAALDEQFEPQK 57
++ V ++TGA G+G+ A+ GAK+ L N LE + + A+ + + K
Sbjct: 49 YLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHK 108
Query: 58 TLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNW--------EKTLQINLV 109
+ D+ D + +++ FG +DILVNNAG++ ++ ++ N
Sbjct: 109 PYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 110 SVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAA 169
++ T L M K+ G I+ +SS+ G M + + Y ASKH F L A
Sbjct: 169 GPVALTKALLPSMIKRRQGH---IVAISSIQGKMSIPFRSAYAASKHATQAF--FDCLRA 223
Query: 170 NLMNSGVRLNAICPGFVNT 188
+ + + I PG+++T
Sbjct: 224 EMEQYEIEVTVISPGYIHT 242
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 62.0 bits (149), Expect = 5e-10
Identities = 51/195 (26%), Positives = 91/195 (46%), Gaps = 12/195 (6%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTL--- 59
V KV ++T A G+G+ A GA++ L N E AL +P KT
Sbjct: 35 VQNKVVVITDAISGLGKECARVFHTGGARLVLCGKNWERLENLYDALISVADPSKTFTPK 94
Query: 60 FIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEK-TLQINLVSVISGTYLG 118
+ D++D + D ++V+D +G +DIL+NNA V + K +L+++ ++ Y G
Sbjct: 95 LVLLDLSDISCVPDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELD-KKIMDANYFG 153
Query: 119 LDYMSK-----QNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN 173
++K G I+ ++++ G + + Y ASKH +GF L A +
Sbjct: 154 PITLTKALLPNMISRRTGQIVLVNNIQGKFGIPFRTTYAASKHAALGF--FDCLRAEVEE 211
Query: 174 SGVRLNAICPGFVNT 188
V ++ + P F+ +
Sbjct: 212 YDVVISTVSPTFIRS 226
>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
Length = 316
Score = 61.6 bits (148), Expect = 7e-10
Identities = 57/205 (27%), Positives = 94/205 (45%), Gaps = 23/205 (11%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
GKV ++TGA GIG+ A L +GA+V + ++ G + + + + L + D
Sbjct: 39 GKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLD 98
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLG 118
++D + +R + +L IL+NNAGV +E L +N + TYL
Sbjct: 99 LSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLL 158
Query: 119 LDYMSKQNGGEGGIIINMSSLA---GLMP---------VAQQPVYCASKHGIVGFTRSAA 166
L+ + ++N+SS+A G +P ++ YC SK V FTR
Sbjct: 159 LERLKVSAPAR---VVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRE-- 213
Query: 167 LAANLMNSGVRLNAICPGFVNTAIL 191
LA L +GV A+ PG V + ++
Sbjct: 214 LAKRLQGTGVTTYAVHPGVVRSELV 238
>gi|22507405 short chain dehydrogenase/reductase family 9C, member 7
[Homo sapiens]
Length = 313
Score = 61.6 bits (148), Expect = 7e-10
Identities = 64/210 (30%), Positives = 93/210 (44%), Gaps = 23/210 (10%)
Query: 2 HVNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFI 61
+++ K +TG G G A+ L+ +G +V L E G Q K D + Q TL
Sbjct: 22 NLSEKYVFITGCDSGFGNLLAKQLVDRGMQV-LAACFTEEGSQ-KLQRDTSYRLQTTLL- 78
Query: 62 QCDVADQQQLRDTFRKVVDHFGR--LDILVNNAGVN---------NEKNWEKTLQINLVS 110
DV + ++ + V D G L LVNNAGV + ++ K + +NLV
Sbjct: 79 --DVTKSESIKAAAQWVRDKVGEQGLWALVNNAGVGLPSGPNEWLTKDDFVKVINVNLVG 136
Query: 111 VISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAAN 170
+I T L + + G ++NMSS G + V YC SK G+ F S ++
Sbjct: 137 LIEVTLHMLPMVKRARGR----VVNMSSSGGRVAVIGGG-YCVSKFGVEAF--SDSIRRE 189
Query: 171 LMNSGVRLNAICPGFVNTAILESIEKEENM 200
L GV++ I PG TAIL E M
Sbjct: 190 LYYFGVKVCIIEPGNYRTAILGKENLESRM 219
>gi|4557649 estradiol 17 beta-dehydrogenase 3 [Homo sapiens]
Length = 310
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/198 (28%), Positives = 89/198 (44%), Gaps = 22/198 (11%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
G+ A++TGA GIG+A++ L +G V L+ LE ++ A E+ + IQ D
Sbjct: 48 GQWAVITGAGDGIGKAYSFELAKRGLNVVLISRTLEK-LEAIATEIERTTGRSVKIIQAD 106
Query: 65 VADQQQLRDTFRKVVDHFGRLD--ILVNNAG----------VNNEKNWEKTLQINLVSVI 112
D + + + L+ ILVNN G +N + + N+ SV+
Sbjct: 107 FTKD----DIYEHIKEKLAGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVV 162
Query: 113 SGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLM 172
T L L +M + + G+I+N+SS L P +Y ASK + F S AL
Sbjct: 163 KMTQLILKHMESR---QKGLILNISSGIALFPWPLYSMYSASKAFVCAF--SKALQEEYK 217
Query: 173 NSGVRLNAICPGFVNTAI 190
V + + P V+TA+
Sbjct: 218 AKEVIIQVLTPYAVSTAM 235
>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
[Homo sapiens]
Length = 232
Score = 60.8 bits (146), Expect = 1e-09
Identities = 56/188 (29%), Positives = 79/188 (42%), Gaps = 16/188 (8%)
Query: 3 VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62
+ KVALVT + GIG A A L A V + + Q A L Q E
Sbjct: 30 LTNKVALVTASTDGIGFAIARRLAQDRAHVVVSSRKQQNVDQAVATL--QGEGLSVTGTV 87
Query: 63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVN---------NEKNWEKTLQINLVSVIS 113
C V + V G +DILV+NA VN E+ W+KTL IN+ +
Sbjct: 88 CHVGKAEDRERLVAMAVKLHGGIDILVSNAAVNPFFGSLMDVTEEVWDKTLDINVKAPAL 147
Query: 114 GTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMN 173
T + M K+ GG ++ +SS+A P Y SK ++G + LA L
Sbjct: 148 MTKAVVPEMEKRGGGS---VVIVSSIAAFSPSPGFSPYNVSKTALLGLNNT--LAIELAP 202
Query: 174 SGVRLNAI 181
+R+N +
Sbjct: 203 RNIRVNCL 210
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 60.5 bits (145), Expect = 2e-09
Identities = 57/205 (27%), Positives = 92/205 (44%), Gaps = 23/205 (11%)
Query: 5 GKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQCD 64
GKV +VTGA GIG+ A+ L +GA+V L ++E G + Q+ L + D
Sbjct: 41 GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQTTTGNQQVLVRKLD 100
Query: 65 VADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKTLQINLVSVISGTYLG 118
++D + +R + + L +L+NNAGV +E + +N + T+L
Sbjct: 101 LSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLL 160
Query: 119 LDYMSKQNGGEGGIIINMSSLA------------GLMPVAQQPVYCASKHGIVGFTRSAA 166
L+ + + I+N+SSLA G YC SK + FT+
Sbjct: 161 LEKLKESAPSR---IVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKLANILFTQE-- 215
Query: 167 LAANLMNSGVRLNAICPGFVNTAIL 191
LA L SGV ++ PG V + ++
Sbjct: 216 LARRLKGSGVTTYSVHPGTVQSELV 240
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,882,185
Number of Sequences: 37866
Number of extensions: 349857
Number of successful extensions: 855
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 27
Number of HSP's that attempted gapping in prelim test: 717
Number of HSP's gapped (non-prelim): 78
length of query: 266
length of database: 18,247,518
effective HSP length: 100
effective length of query: 166
effective length of database: 14,460,918
effective search space: 2400512388
effective search space used: 2400512388
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.