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Search of human proteins with 31317224
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31317224 EGF-like repeats and discoidin I-like
domains-containing protein 3 [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31317224 EGF-like repeats and discoidin I-like domains-contai... 1034 0.0
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho... 397 e-111
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho... 311 1e-84
gi|105990535 coagulation factor V precursor [Homo sapiens] 266 4e-71
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap... 255 7e-68
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa... 183 3e-46
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 172 8e-43
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 172 8e-43
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 172 8e-43
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 172 8e-43
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 172 8e-43
gi|66864913 neuropilin 1 isoform c [Homo sapiens] 169 5e-42
gi|66912178 neuropilin 1 isoform b [Homo sapiens] 169 5e-42
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 169 5e-42
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 147 2e-35
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa... 139 4e-33
gi|24041035 notch 2 preproprotein [Homo sapiens] 116 5e-26
gi|148833508 notch1 preproprotein [Homo sapiens] 112 6e-25
gi|134244285 Notch homolog 3 [Homo sapiens] 108 1e-23
gi|110735443 delta-like 1 [Homo sapiens] 107 2e-23
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 106 4e-23
gi|122937283 6720455I24Rik homolog [Homo sapiens] 106 5e-23
gi|10835083 X-linked juvenile retinoschisis protein precursor [H... 105 7e-23
gi|148886654 polydom [Homo sapiens] 105 9e-23
gi|4557679 jagged 1 precursor [Homo sapiens] 103 3e-22
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 103 3e-22
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 103 3e-22
gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo sa... 103 3e-22
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 102 6e-22
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 102 8e-22
>gi|31317224 EGF-like repeats and discoidin I-like
domains-containing protein 3 [Homo sapiens]
Length = 480
Score = 1034 bits (2673), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS 60
MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS
Sbjct: 1 MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS 60
Query: 61 SVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI 120
SVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI
Sbjct: 61 SVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI 120
Query: 121 NECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTH 180
NECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTH
Sbjct: 121 NECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTH 180
Query: 181 RALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSP 240
RALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSP
Sbjct: 181 RALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSP 240
Query: 241 EYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQV 300
EYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQV
Sbjct: 241 EYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQV 300
Query: 301 CRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDK 360
CRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDK
Sbjct: 301 CRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDK 360
Query: 361 QGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWT 420
QGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWT
Sbjct: 361 QGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWT 420
Query: 421 VYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE 480
VYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE
Sbjct: 421 VYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE 480
>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
sapiens]
Length = 387
Score = 397 bits (1021), Expect = e-111
Identities = 198/401 (49%), Positives = 254/401 (63%), Gaps = 42/401 (10%)
Query: 78 CTPNPCHNGGTCE-ISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTD 136
C+ NPCHNGG CE IS+ RGD F Y C C +G+ G HC
Sbjct: 27 CSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHC-------------------- 66
Query: 137 LVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARL 196
+ KC PLG+E G I+N QI ASS GLQ W P ARL
Sbjct: 67 ------------------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL 108
Query: 197 NKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKT 256
N+ G++NAWT + ND PWIQ+NL R+M VTGV+TQGA R+ S EY+K++K+AYS +G
Sbjct: 109 NRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHE 168
Query: 257 W-AMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCE 315
+ ++ V +++ V GN + N + N F P++AQYVRLYP C CTLR ELLGCE
Sbjct: 169 FDFIHDVNKKHKEFV--GNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCE 226
Query: 316 LSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQS 375
L+GC+ PLG+K+ I D QITASS ++T + +F+W P ARLDKQG NAW +G
Sbjct: 227 LNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGND 286
Query: 376 QWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQG 435
QWLQVDL +VTGIITQGA++FG VQFV SYK+AYSND +WT YQD + K+F G
Sbjct: 287 QWLQVDLGSSKEVTGIITQGARNFGSVQFVASYKVAYSNDSANWTEYQDPRTGSSKIFPG 346
Query: 436 NFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
N+DN +H+KN+ + PI AR++RILP +W+ RI LR ELLGC
Sbjct: 347 NWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 387
Score = 37.7 bits (86), Expect = 0.023
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 6/44 (13%)
Query: 24 DICDPNPCENGGIC------LPGLADGSFSCECPDGFTDPNCSS 61
DIC NPC NGG+C + G S++C C G+ +C +
Sbjct: 25 DICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCET 68
>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
sapiens]
Length = 335
Score = 311 bits (796), Expect = 1e-84
Identities = 166/401 (41%), Positives = 216/401 (53%), Gaps = 94/401 (23%)
Query: 78 CTPNPCHNGGTCE-ISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTD 136
C+ NPCHNGG CE IS+ RGD F Y C C +G+ G HC
Sbjct: 27 CSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHC-------------------- 66
Query: 137 LVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARL 196
+ KC PLG+E G I+N QI ASS GLQ W P ARL
Sbjct: 67 ------------------ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL 108
Query: 197 NKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKT 256
N+ G++NAWT + ND PWIQ+NL R+M VTGV+TQGA R+ S EY+K++K+AYS +G
Sbjct: 109 NRAGMVNAWTPSSNDDNPWIQVNLLRRMWVTGVVTQGASRLASHEYLKAFKVAYSLNGHE 168
Query: 257 W-AMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCE 315
+ ++ V +++ V GN + N + N F P++AQYVRLYP C CTLR ELLGCE
Sbjct: 169 FDFIHDVNKKHKEFV--GNWNKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCE 226
Query: 316 LSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQS 375
L+GC+ PLG+K+ I D QITASS ++T + +F+W P ARLDKQG NAW +G
Sbjct: 227 LNGCANPLGLKNNSIPDKQITASSSYKTWGLHLFSWNPSYARLDKQGNFNAWVAGSYGND 286
Query: 376 QWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQG 435
QWLQ+ F G
Sbjct: 287 QWLQI----------------------------------------------------FPG 294
Query: 436 NFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
N+DN +H+KN+ + PI AR++RILP +W+ RI LR ELLGC
Sbjct: 295 NWDNHSHKKNLFETPILARYVRILPVAWHNRIALRLELLGC 335
Score = 37.7 bits (86), Expect = 0.023
Identities = 16/44 (36%), Positives = 23/44 (52%), Gaps = 6/44 (13%)
Query: 24 DICDPNPCENGGIC------LPGLADGSFSCECPDGFTDPNCSS 61
DIC NPC NGG+C + G S++C C G+ +C +
Sbjct: 25 DICSKNPCHNGGLCEEISQEVRGDVFPSYTCTCLKGYAGNHCET 68
>gi|105990535 coagulation factor V precursor [Homo sapiens]
Length = 2224
Score = 266 bits (679), Expect = 4e-71
Identities = 144/337 (42%), Positives = 198/337 (58%), Gaps = 16/337 (4%)
Query: 144 ECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLIN 203
+ P M R+C+ P+G+ GIIS+ QI AS L W P ARLN G N
Sbjct: 1897 QTPFLIMDRDCRM----PMGLSTGIISDSQIKASEF------LGYWEPRLARLNNGGSYN 1946
Query: 204 AWT----AAENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAM 259
AW+ AAE PWIQ+++Q+++ +TG+ TQGAK Y + +AYS++ W +
Sbjct: 1947 AWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQI 2006
Query: 260 YKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGC 319
+K T M F GN D +T N F PPI A+Y+R+ P TLR+EL GCE++GC
Sbjct: 2007 FKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGC 2066
Query: 320 SEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQ 379
S PLGM++G I++ QITASS ++ D WEP +ARL+ QG+VNAW + N+ QWL+
Sbjct: 2067 STPLGMENGKIENKQITASSFKKSWWGDY--WEPFRARLNAQGRVNAWQAKANNNKQWLE 2124
Query: 380 VDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDN 439
+DLL K+T IITQG K +V SY + YS G W Y+ + DK+F+GN +
Sbjct: 2125 IDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNT 2184
Query: 440 DTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
H KN +PPI +R IR++P +W I LR EL GC
Sbjct: 2185 KGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGC 2221
Score = 141 bits (356), Expect = 1e-33
Identities = 66/159 (41%), Positives = 99/159 (62%), Gaps = 1/159 (0%)
Query: 158 CSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQ 217
CS PLG+E G I N+QITASS ++ +G W P+ ARLN +G +NAW A N+ W++
Sbjct: 2066 CSTPLGMENGKIENKQITASSFKKSWWG-DYWEPFRARLNAQGRVNAWQAKANNNKQWLE 2124
Query: 218 INLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDN 277
I+L + ++T +ITQG K + S Y+KSY I YS G W Y++K + D +F GN +
Sbjct: 2125 IDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNT 2184
Query: 278 NTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCEL 316
N F PPI ++++R+ P+ + LR+EL GC++
Sbjct: 2185 KGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223
>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
Length = 2351
Score = 255 bits (651), Expect = 7e-68
Identities = 143/324 (44%), Positives = 190/324 (58%), Gaps = 13/324 (4%)
Query: 157 KCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWI 216
KC PLG+ G I + QITAS + +W P ARL+ G INAW+ E + WI
Sbjct: 2039 KCQTPLGMASGHIRDFQITASGQYG------QWAPKLARLHYSGSINAWSTKEP--FSWI 2090
Query: 217 QINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNID 276
+++L M + G+ TQGA++ S YI + I YS DGK W Y+ T MVF GN+D
Sbjct: 2091 KVDLLAPMIIHGIKTQGARQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNVD 2150
Query: 277 NNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQIT 336
++ N F PPI A+Y+RL+P TLRMEL+GC+L+ CS PLGM+S I D QIT
Sbjct: 2151 SSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKAISDAQIT 2210
Query: 337 ASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGA 396
ASS F + TW P KARL QG+ NAW N+ +WLQVD KVTG+ TQG
Sbjct: 2211 ASSYFTNM---FATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVTGVTTQGV 2267
Query: 397 KDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHI 456
K +V + ++ S DG WT++ + K KVFQGN D+ T N +DPP+ R++
Sbjct: 2268 KSLLTSMYVKEFLISSSQDGHQWTLF--FQNGKVKVFQGNQDSFTPVVNSLDPPLLTRYL 2325
Query: 457 RILPWSWYGRITLRSELLGCTEEE 480
RI P SW +I LR E+LGC ++
Sbjct: 2326 RIHPQSWVHQIALRMEVLGCEAQD 2349
>gi|10518506 coagulation factor VIII isoform b precursor [Homo
sapiens]
Length = 216
Score = 183 bits (465), Expect = 3e-46
Identities = 98/211 (46%), Positives = 129/211 (61%), Gaps = 5/211 (2%)
Query: 270 VFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPLGMKSGH 329
VF GN+D++ N F PPI A+Y+RL+P TLRMEL+GC+L+ CS PLGM+S
Sbjct: 9 VFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNSCSMPLGMESKA 68
Query: 330 IQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQVDLLVPTKVT 389
I D QITASS F + TW P KARL QG+ NAW N+ +WLQVD KVT
Sbjct: 69 ISDAQITASSYFTNM---FATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVDFQKTMKVT 125
Query: 390 GIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVIDP 449
G+ TQG K +V + ++ S DG WT++ + K KVFQGN D+ T N +DP
Sbjct: 126 GVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLF--FQNGKVKVFQGNQDSFTPVVNSLDP 183
Query: 450 PIYARHIRILPWSWYGRITLRSELLGCTEEE 480
P+ R++RI P SW +I LR E+LGC ++
Sbjct: 184 PLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 214
Score = 129 bits (324), Expect = 6e-30
Identities = 71/168 (42%), Positives = 99/168 (58%), Gaps = 5/168 (2%)
Query: 148 EFMGRNCQYKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTA 207
E MG + CS PLG+E IS+ QITASS +F W P ARL+ +G NAW
Sbjct: 49 ELMGCDLN-SCSMPLGMESKAISDAQITASSYFTNMFAT--WSPSKARLHLQGRSNAWRP 105
Query: 208 AENDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNE 267
N+ W+Q++ Q+ M+VTGV TQG K + + Y+K + I+ S DG W ++ G +
Sbjct: 106 QVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNG--K 163
Query: 268 DMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCE 315
VF+GN D+ TP NS PP+ +Y+R++PQ LRME+LGCE
Sbjct: 164 VKVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCE 211
Score = 48.9 bits (115), Expect = 1e-05
Identities = 24/50 (48%), Positives = 32/50 (64%)
Query: 427 QRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
Q KVF GN D+ + N+ +PPI AR+IR+ P + R TLR EL+GC
Sbjct: 4 QDPGKVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGC 53
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 172 bits (435), Expect = 8e-43
Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST+ +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442
G+I QGA+ + FV +K++YS +G+ W QD + ++ K+F+GN DT
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
Query: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476
D PI A+++R+ P W I +R E+LGC
Sbjct: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 172 bits (435), Expect = 8e-43
Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST+ +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442
G+I QGA+ + FV +K++YS +G+ W QD + ++ K+F+GN DT
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
Query: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476
D PI A+++R+ P W I +R E+LGC
Sbjct: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 172 bits (435), Expect = 8e-43
Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST+ +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442
G+I QGA+ + FV +K++YS +G+ W QD + ++ K+F+GN DT
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
Query: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476
D PI A+++R+ P W I +R E+LGC
Sbjct: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 172 bits (435), Expect = 8e-43
Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST+ +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442
G+I QGA+ + FV +K++YS +G+ W QD + ++ K+F+GN DT
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
Query: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476
D PI A+++R+ P W I +R E+LGC
Sbjct: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 172 bits (435), Expect = 8e-43
Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST+ +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442
G+I QGA+ + FV +K++YS +G+ W QD + ++ K+F+GN DT
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
Query: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476
D PI A+++R+ P W I +R E+LGC
Sbjct: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
Length = 609
Score = 169 bits (428), Expect = 5e-42
Identities = 118/332 (35%), Positives = 168/332 (50%), Gaps = 26/332 (7%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
+KC LG+E G I + QITASS + W +RLN N WT E+ W
Sbjct: 273 FKCMEALGMESGEIHSDQITASSQYST-----NWSAERSRLNYPE--NGWTPGEDSYREW 325
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
IQ++L VT V TQGA K Y+K+YKI S++G+ W +K N+ ++F+G
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWIT--IKEGNKPVLFQG 383
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N + F P+ ++VR+ P ++R E+ GC+++ CS LGM SG I
Sbjct: 384 NTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLIS 443
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWT---SGHNDQSQWLQVDLLVPTKV 388
D QIT+S N W P RL + W + H+ ++WLQ+DL V
Sbjct: 444 DSQITSS------NQGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 389 TGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVID 448
GII QG K + F+ +K+ YSN+G W + D+ +RK K F+GN + DT
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 449 PPIYARHIRILP-WSWYGRITLRSELLGCTEE 479
P + R IRI P + +G + LR ELLGC E
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
Score = 94.0 bits (232), Expect = 3e-19
Identities = 61/184 (33%), Positives = 93/184 (50%), Gaps = 12/184 (6%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWT---AAENDR 212
Y CSG LG+ G+IS+ QIT+S+ G + W P RL + W A +
Sbjct: 429 YPCSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSR--SGWALPPAPHSYI 481
Query: 213 WPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272
W+QI+L + V G+I QG K + +++ +KI YSN+G W M + F
Sbjct: 482 NEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFE 541
Query: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQ-VCRRHCTLRMELLGCELSGCSEPLGMKSGHIQ 331
GN + +TP +F P + +++R+YP+ LRMELLGCE+ G + L + +
Sbjct: 542 GNNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTVI 600
Query: 332 DYQI 335
D I
Sbjct: 601 DSTI 604
>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
Length = 644
Score = 169 bits (428), Expect = 5e-42
Identities = 118/332 (35%), Positives = 168/332 (50%), Gaps = 26/332 (7%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
+KC LG+E G I + QITASS + W +RLN N WT E+ W
Sbjct: 273 FKCMEALGMESGEIHSDQITASSQYST-----NWSAERSRLNYPE--NGWTPGEDSYREW 325
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
IQ++L VT V TQGA K Y+K+YKI S++G+ W +K N+ ++F+G
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWIT--IKEGNKPVLFQG 383
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N + F P+ ++VR+ P ++R E+ GC+++ CS LGM SG I
Sbjct: 384 NTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLIS 443
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWT---SGHNDQSQWLQVDLLVPTKV 388
D QIT+S N W P RL + W + H+ ++WLQ+DL V
Sbjct: 444 DSQITSS------NQGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 389 TGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVID 448
GII QG K + F+ +K+ YSN+G W + D+ +RK K F+GN + DT
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 449 PPIYARHIRILP-WSWYGRITLRSELLGCTEE 479
P + R IRI P + +G + LR ELLGC E
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
Score = 91.7 bits (226), Expect = 1e-18
Identities = 59/181 (32%), Positives = 92/181 (50%), Gaps = 12/181 (6%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWT---AAENDR 212
Y CSG LG+ G+IS+ QIT+S+ G + W P RL + W A +
Sbjct: 429 YPCSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSR--SGWALPPAPHSYI 481
Query: 213 WPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272
W+QI+L + V G+I QG K + +++ +KI YSN+G W M + F
Sbjct: 482 NEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFE 541
Query: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQ-VCRRHCTLRMELLGCELSGCSEPLGMKSGHIQ 331
GN + +TP +F P + +++R+YP+ LRMELLGCE+ + +G++
Sbjct: 542 GNNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
Query: 332 D 332
D
Sbjct: 601 D 601
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 169 bits (428), Expect = 5e-42
Identities = 118/332 (35%), Positives = 168/332 (50%), Gaps = 26/332 (7%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
+KC LG+E G I + QITASS + W +RLN N WT E+ W
Sbjct: 273 FKCMEALGMESGEIHSDQITASSQYST-----NWSAERSRLNYPE--NGWTPGEDSYREW 325
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
IQ++L VT V TQGA K Y+K+YKI S++G+ W +K N+ ++F+G
Sbjct: 326 IQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWIT--IKEGNKPVLFQG 383
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N + F P+ ++VR+ P ++R E+ GC+++ CS LGM SG I
Sbjct: 384 NTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLIS 443
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWT---SGHNDQSQWLQVDLLVPTKV 388
D QIT+S N W P RL + W + H+ ++WLQ+DL V
Sbjct: 444 DSQITSS------NQGDRNWMPENIRLVTSR--SGWALPPAPHSYINEWLQIDLGEEKIV 495
Query: 389 TGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTHRKNVID 448
GII QG K + F+ +K+ YSN+G W + D+ +RK K F+GN + DT
Sbjct: 496 RGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTF- 554
Query: 449 PPIYARHIRILP-WSWYGRITLRSELLGCTEE 479
P + R IRI P + +G + LR ELLGC E
Sbjct: 555 PALSTRFIRIYPERATHGGLGLRMELLGCEVE 586
Score = 91.7 bits (226), Expect = 1e-18
Identities = 59/181 (32%), Positives = 92/181 (50%), Gaps = 12/181 (6%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWT---AAENDR 212
Y CSG LG+ G+IS+ QIT+S+ G + W P RL + W A +
Sbjct: 429 YPCSGMLGMVSGLISDSQITSSNQ-----GDRNWMPENIRLVTSR--SGWALPPAPHSYI 481
Query: 213 WPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272
W+QI+L + V G+I QG K + +++ +KI YSN+G W M + F
Sbjct: 482 NEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFE 541
Query: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQ-VCRRHCTLRMELLGCELSGCSEPLGMKSGHIQ 331
GN + +TP +F P + +++R+YP+ LRMELLGCE+ + +G++
Sbjct: 542 GNNNYDTPELRTF-PALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV 600
Query: 332 D 332
D
Sbjct: 601 D 601
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 147 bits (371), Expect = 2e-35
Identities = 100/290 (34%), Positives = 150/290 (51%), Gaps = 29/290 (10%)
Query: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215
++C+ PLG+E G I+N+QI+ASST + +W P +RL+ G N WT + +
Sbjct: 275 FQCNVPLGMESGRIANEQISASST----YSDGRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
Query: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273
+Q++L+ +T + TQGA + + Y+KSYK+ S +G+ W +Y+ G N VF+
Sbjct: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNH-KVFQA 386
Query: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331
N D N P+ ++VR+ PQ LR+EL GC ++ CS LGM SG I
Sbjct: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
Query: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388
D QI+ASS + W P ARL + W +WLQVDL P V
Sbjct: 447 DSQISASS------TQEYLWSPSAARL--VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTV 498
Query: 389 TGIITQGAKDFGHV------QFVGSYKLAYSNDGEHWTVYQDEKQRKDKV 432
G+I QGA+ + FV +K++YS +G+ W QD + ++ KV
Sbjct: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKV 548
Score = 106 bits (264), Expect = 5e-23
Identities = 65/160 (40%), Positives = 88/160 (55%), Gaps = 11/160 (6%)
Query: 319 CSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWL 378
C+ PLGM+SG I + QI+ASS + W P+++RL G N WT + ++L
Sbjct: 277 CNVPLGMESGRIANEQISASSTYSDGR-----WTPQQSRL--HGDDNGWTPNLDSNKEYL 329
Query: 379 QVDLLVPTKVTGIITQGA--KDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGN 436
QVDL T +T I TQGA ++ + +V SYKL S +GE W VY+ K K VFQ N
Sbjct: 330 QVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQAN 387
Query: 437 FDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
D N + P+ R +RI P +W+ I LR EL GC
Sbjct: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGC 427
>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
sapiens]
Length = 775
Score = 139 bits (351), Expect = 4e-33
Identities = 75/172 (43%), Positives = 102/172 (59%), Gaps = 4/172 (2%)
Query: 307 LRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNM--DMFTWEPRKARLDKQGKV 364
L L + SGC LGM+SG I D QITASS+ + +W+P+KARL K G
Sbjct: 280 LSTSLFTFKTSGCYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGP- 338
Query: 365 NAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQD 424
W + D+ QWLQ+DL K+TGIIT G+ H +V +Y++ YS+DG+ WTVY++
Sbjct: 339 -PWAAFATDEYQWLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYRE 397
Query: 425 EKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
+DK+FQGN D +N PPI AR IR+ P W +I ++ ELLGC
Sbjct: 398 PGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGC 449
Score = 126 bits (317), Expect = 4e-29
Identities = 61/161 (37%), Positives = 96/161 (59%), Gaps = 5/161 (3%)
Query: 158 CSGPLGIEGGIISNQQITASSTHRALFGL---QKWYPYYARLNKKGLINAWTAAENDRWP 214
C G LG+E G+I++ QITASS W P ARL K G W A D +
Sbjct: 292 CYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPG--PPWAAFATDEYQ 349
Query: 215 WIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGN 274
W+QI+L ++ ++TG+IT G+ + Y+ +Y+I YS+DG+ W +Y+ G +D +F+GN
Sbjct: 350 WLQIDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGN 409
Query: 275 IDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCE 315
D + N+F PPI A+++R+ P ++ ++MELLGC+
Sbjct: 410 KDYHQDVRNNFLPPIIARFIRVNPTQWQQKIAMKMELLGCQ 450
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 116 bits (290), Expect = 5e-26
Identities = 62/166 (37%), Positives = 74/166 (44%), Gaps = 44/166 (26%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C NPC+NGG C+ G+ +FSC C GFT C T C PC
Sbjct: 913 DDCLANPCQNGGSCMDGV--NTFSCLCLPGFTGDKCQ------------TDMNECLSEPC 958
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGGTC D Y CKC GF+G+HC++NINEC C NGG C D + ++SC
Sbjct: 959 KNGGTCS-------DYVNSYTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSC 1011
Query: 144 ECPGEFMGRNC-----------------------QYKCSGPLGIEG 166
CP F G C Y+CS PLG G
Sbjct: 1012 LCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTG 1057
Score = 105 bits (262), Expect = 9e-23
Identities = 52/130 (40%), Positives = 69/130 (53%), Gaps = 21/130 (16%)
Query: 26 CD-PNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCH 84
CD P C++GG CL GS+ C+CP GFT C S+ PC P+PC
Sbjct: 186 CDIPGHCQHGGTCLN--LPGSYQCQCPQGFTGQYCDSLYV------------PCAPSPCV 231
Query: 85 NGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCE 144
NGGTC + GD + C C GF G C+ NI++C C+NGG+C D V Y+C
Sbjct: 232 NGGTCRQT----GD--FTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCR 285
Query: 145 CPGEFMGRNC 154
CP ++ G+ C
Sbjct: 286 CPPQWTGQFC 295
Score = 100 bits (250), Expect = 2e-21
Identities = 55/159 (34%), Positives = 69/159 (43%), Gaps = 38/159 (23%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCT---- 79
D C NPC G C+ G+ F C CP+G P+C S V P G CT
Sbjct: 684 DECASNPCRKGATCINGV--NGFRCICPEGPHHPSCYSQVNECLSN--PCIHGNCTGGLS 739
Query: 80 -----------------------PNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHC 116
NPC NGGTC+ + GY C C +GF G +C
Sbjct: 740 GYKCLCDAGWVGINCEVDKNECLSNPCQNGGTCD-------NLVNGYRCTCKKGFKGYNC 792
Query: 117 QHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
Q NI+EC PC N G C D ++ Y+C C + G+NCQ
Sbjct: 793 QVNIDECASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQ 831
Score = 99.4 bits (246), Expect = 7e-21
Identities = 48/131 (36%), Positives = 61/131 (46%), Gaps = 21/131 (16%)
Query: 25 ICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCH 84
+ + NPCE+ G C+ DG+F CEC G+ P C + C +PC
Sbjct: 421 MANSNPCEHAGKCVN--TDGAFHCECLKGYAGPRCEMDIN------------ECHSDPCQ 466
Query: 85 NGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCE 144
N TC D G+ C C GF G+HC+ INEC+ PC N G C D V + C
Sbjct: 467 NDATCL-------DKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCL 519
Query: 145 CPGEFMGRNCQ 155
CP F G CQ
Sbjct: 520 CPPGFTGPVCQ 530
Score = 96.7 bits (239), Expect = 4e-20
Identities = 46/132 (34%), Positives = 64/132 (48%), Gaps = 19/132 (14%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C NPC N G C ++ ++C C +T NC +V+ PC+PNPC
Sbjct: 797 DECASNPCLNQGTCFDDIS--GYTCHCVLPYTGKNCQTVL------------APCSPNPC 842
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
N C+ S F Y C C G+ G C +I+EC +PC N G+C + +Y C
Sbjct: 843 ENAAVCKESP-----NFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMC 897
Query: 144 ECPGEFMGRNCQ 155
ECP F G +C+
Sbjct: 898 ECPPGFSGMDCE 909
Score = 96.7 bits (239), Expect = 4e-20
Identities = 44/130 (33%), Positives = 63/130 (48%), Gaps = 19/130 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PNPCEN +C S++C C G+ C+ ++ C PC N
Sbjct: 837 CSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDID------------ECISKPCMN 884
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G C ++ Y+C+CP GF+G+ C+ +I++C PC+NGG C D V +SC C
Sbjct: 885 HGLCHNTQG-------SYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLC 937
Query: 146 PGEFMGRNCQ 155
F G CQ
Sbjct: 938 LPGFTGDKCQ 947
Score = 95.9 bits (237), Expect = 7e-20
Identities = 45/141 (31%), Positives = 70/141 (49%), Gaps = 25/141 (17%)
Query: 31 CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCE 90
C++ G+C+ A + C+CP G+T C ++ C NPC +G TC
Sbjct: 1120 CQHSGVCIN--AGNTHYCQCPLGYTGSYCEEQLD------------ECASNPCQHGATCS 1165
Query: 91 ISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFM 150
D GY C+C G+ G++C++ ++EC+ +PC+NGG C DLV ++ C CP
Sbjct: 1166 -------DFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTR 1218
Query: 151 GRNCQYK----CSGPLGIEGG 167
G C+ GP + GG
Sbjct: 1219 GLLCEENIDDCARGPHCLNGG 1239
Score = 88.6 bits (218), Expect = 1e-17
Identities = 48/164 (29%), Positives = 72/164 (43%), Gaps = 44/164 (26%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPC-TPNP 82
D C+ N C+NGG C+ G +C C GFT +C + +++ PC P
Sbjct: 66 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC-----------QYSTSHPCFVSRP 114
Query: 83 CHNGGTCEI--SEAYRGDTFIGYV-----------------------------CKCPRGF 111
C NGGTC + + Y +G+ CKC GF
Sbjct: 115 CLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGF 174
Query: 112 NGIHCQHNINECEVE-PCKNGGICTDLVANYSCECPGEFMGRNC 154
G C+ ++NEC++ C++GG C +L +Y C+CP F G+ C
Sbjct: 175 TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYC 218
Score = 88.6 bits (218), Expect = 1e-17
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 11/134 (8%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
++C +PC+N G C+ A+ C CP G+ C V S + + G + C
Sbjct: 1065 NLCSRSPCKNKGTCVQKKAES--QCLCPSGWAGAYCD--VPNVSCDIAASRRGVLVEHLC 1120
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
+ G C G+T + C+CP G+ G +C+ ++EC PC++G C+D + Y C
Sbjct: 1121 QHSGVC----INAGNT---HYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRC 1173
Query: 144 ECPGEFMGRNCQYK 157
EC + G NC+Y+
Sbjct: 1174 ECVPGYQGVNCEYE 1187
Score = 88.2 bits (217), Expect = 2e-17
Identities = 47/129 (36%), Positives = 57/129 (44%), Gaps = 21/129 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C + C NGG C+ G+ SFSC CP GFT C + C+ +PC N
Sbjct: 991 CTESSCFNGGTCVDGI--NSFSCLCPVGFTGSFCLHEIN------------ECSSHPCLN 1036
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GTC D Y C CP G+ G +CQ +N C PCKN G C A C C
Sbjct: 1037 EGTCV-------DGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLC 1089
Query: 146 PGEFMGRNC 154
P + G C
Sbjct: 1090 PSGWAGAYC 1098
Score = 86.3 bits (212), Expect = 6e-17
Identities = 44/131 (33%), Positives = 62/131 (47%), Gaps = 19/131 (14%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C + C+NGG+C+ G+ +++C CP +T C+ V+ + PN C
Sbjct: 262 DDCPNHRCQNGGVCVDGV--NTYNCRCPPQWTGQFCTEDVDECLLQ----------PNAC 309
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGGTC GY C C G++G C NI++C C G C D VA++SC
Sbjct: 310 QNGGTCANRNG-------GYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSC 362
Query: 144 ECPGEFMGRNC 154
CP G C
Sbjct: 363 MCPEGKAGLLC 373
Score = 83.2 bits (204), Expect = 5e-16
Identities = 51/166 (30%), Positives = 65/166 (39%), Gaps = 48/166 (28%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C NPC++G C + G + CEC G+ NC V+ C PC
Sbjct: 1151 DECASNPCQHGATCSDFI--GGYRCECVPGYQGVNCEYEVD------------ECQNQPC 1196
Query: 84 HNGGTC----------------------EISEAYRG----------DTFIGYVCKCPRGF 111
NGGTC I + RG D GY C+C GF
Sbjct: 1197 QNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGF 1256
Query: 112 NGIHCQHNINECEVEPCKNGGI--CTDLVANYSCECPGEFMGRNCQ 155
G C+ +INEC PC + G C L +Y C C F GR+C+
Sbjct: 1257 AGERCEGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCE 1302
Score = 82.4 bits (202), Expect = 8e-16
Identities = 49/156 (31%), Positives = 61/156 (39%), Gaps = 36/156 (23%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDE---------EEPT--- 73
C NPC N G C+ + F C CP GFT P C ++ S + P
Sbjct: 498 CQSNPCVNNGQCVDKV--NRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYE 555
Query: 74 --------------SAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHN 119
+ C P+PCH+G C+ D Y C C G+ G C
Sbjct: 556 CQCATGFTGVLCEENIDNCDPDPCHHG-QCQ-------DGIDSYTCICNPGYMGAICSDQ 607
Query: 120 INECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
I+EC PC N G C DLV Y C C G NC+
Sbjct: 608 IDECYSSPCLNDGRCIDLVNGYQCNCQPGTSGVNCE 643
Score = 81.3 bits (199), Expect = 2e-15
Identities = 43/130 (33%), Positives = 55/130 (42%), Gaps = 21/130 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C +PC+N CL + G F+C C GF +C + C NPC N
Sbjct: 460 CHSDPCQNDATCLDKI--GGFTCLCMPGFKGVHCELEIN------------ECQSNPCVN 505
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G C D + C CP GF G CQ +I++C PC NG C D Y C+C
Sbjct: 506 NGQCV-------DKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQC 558
Query: 146 PGEFMGRNCQ 155
F G C+
Sbjct: 559 ATGFTGVLCE 568
Score = 77.8 bits (190), Expect = 2e-14
Identities = 46/130 (35%), Positives = 62/130 (47%), Gaps = 22/130 (16%)
Query: 30 PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTC 89
PC N G+C+ +G+ C+CP+GF C PC N C NGGTC
Sbjct: 34 PCVNEGMCVT-YHNGTGYCKCPEGFLGEYCQ-------------HRDPCEKNRCQNGGTC 79
Query: 90 EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINE-CEV-EPCKNGGICTDLVAN-YSCECP 146
+++A G C+C GF G CQ++ + C V PC NGG C L + Y C C
Sbjct: 80 -VAQAMLGKA----TCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQ 134
Query: 147 GEFMGRNCQY 156
F G+ CQ+
Sbjct: 135 VGFTGKECQW 144
Score = 76.6 bits (187), Expect = 5e-14
Identities = 43/132 (32%), Positives = 60/132 (45%), Gaps = 23/132 (17%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C NPC +G IC+ G+ +SC C GFT C+ ++ C NPC
Sbjct: 647 DDCASNPCIHG-ICMDGI--NRYSCVCSPGFTGQRCNIDID------------ECASNPC 691
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
G TC + G+ C CP G + C +NEC PC +G CT ++ Y C
Sbjct: 692 RKGATCI-------NGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGN-CTGGLSGYKC 743
Query: 144 ECPGEFMGRNCQ 155
C ++G NC+
Sbjct: 744 LCDAGWVGINCE 755
Score = 76.3 bits (186), Expect = 6e-14
Identities = 42/139 (30%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 24 DICDPNP-CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNP 82
D C P C NGG C+ + G +SC C GF C + C NP
Sbjct: 1227 DDCARGPHCLNGGQCMDRI--GGYSCRCLPGFAGERCEGDIN------------ECLSNP 1272
Query: 83 CHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGIC---TDLVA 139
C + G+ + + Y+C C F G HC+ ++ C PC NGG C +++
Sbjct: 1273 CSSEGSLDCIQLTND-----YLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPD 1327
Query: 140 NYSCECPGEFMGRNCQYKC 158
+ C CP F G CQ C
Sbjct: 1328 GFICRCPPGFSGARCQSSC 1346
Score = 72.0 bits (175), Expect = 1e-12
Identities = 44/148 (29%), Positives = 62/148 (41%), Gaps = 24/148 (16%)
Query: 22 KGDI--CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCT 79
+GDI C NPC + G + C C FT +C + V+V C
Sbjct: 1262 EGDINECLSNPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETFVDV------------CP 1309
Query: 80 PNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVA 139
PC NGGTC ++ G++C+CP GF+G CQ + C C+ G C +
Sbjct: 1310 QMPCLNGGTCAVASNMPD----GFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTAS 1362
Query: 140 NYSCECPGEFMGRNCQYKCSGPLGIEGG 167
C CP R+C+ C+ GG
Sbjct: 1363 GPRCFCPSP---RDCESGCASSPCQHGG 1387
Score = 66.2 bits (160), Expect = 6e-11
Identities = 41/123 (33%), Positives = 54/123 (43%), Gaps = 22/123 (17%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C +PC N G C+ L +G + C C G + NC E+ D+ C NPC
Sbjct: 609 DECYSSPCLNDGRCID-LVNG-YQCNCQPGTSGVNC----EINFDD--------CASNPC 654
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
+G C D Y C C GF G C +I+EC PC+ G C + V + C
Sbjct: 655 IHG-ICM-------DGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCINGVNGFRC 706
Query: 144 ECP 146
CP
Sbjct: 707 ICP 709
Score = 65.1 bits (157), Expect = 1e-10
Identities = 35/82 (42%), Positives = 42/82 (51%), Gaps = 9/82 (10%)
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICT--DLVA 139
PC N G C Y T GY CKCP GF G +CQH + CE C+NGG C ++
Sbjct: 34 PCVNEGMCV---TYHNGT--GY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLG 86
Query: 140 NYSCECPGEFMGRNCQYKCSGP 161
+C C F G +CQY S P
Sbjct: 87 KATCRCASGFTGEDCQYSTSHP 108
Score = 35.4 bits (80), Expect = 0.12
Identities = 33/151 (21%), Positives = 52/151 (34%), Gaps = 25/151 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVE-------------VASDEEEP 72
C +PC++GG C P +SC+C F+ C A +
Sbjct: 1378 CASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLSQYCADKARDG 1437
Query: 73 TSAGPCTPNPCH-NGGTCEIS-EAYRGDTFIGYVC------KCPRGFNGIHCQHNINECE 124
C + C +GG C ++ E + C +C N + C + EC+
Sbjct: 1438 VCDEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQ 1497
Query: 125 --VEPCKNGGICTDLVANYSCE--CPGEFMG 151
+ CK C D + C+ C E G
Sbjct: 1498 GNSKTCKYDKYCADHFKDNHCDQGCNSEECG 1528
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 112 bits (281), Expect = 6e-25
Identities = 60/157 (38%), Positives = 72/157 (45%), Gaps = 34/157 (21%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEE------------- 70
D C NPC NGG C G+ F+C CP+G+ DP C S V +
Sbjct: 680 DECAGNPCHNGGTCEDGI--NGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGY 737
Query: 71 ----EPTSAGP--------CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQH 118
+P +G C NPC NGGTC+ D GYVC C GF+G +CQ
Sbjct: 738 KCDCDPGWSGTNCDINNNECESNPCVNGGTCK-------DMTSGYVCTCREGFSGPNCQT 790
Query: 119 NINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
NINEC PC N G C D VA Y C C + G C+
Sbjct: 791 NINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCE 827
Score = 105 bits (263), Expect = 7e-23
Identities = 57/161 (35%), Positives = 73/161 (45%), Gaps = 36/161 (22%)
Query: 22 KGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEE----------- 70
+ D C NPC NGG CLP + S+ C CP F P C V +
Sbjct: 140 QADPCASNPCANGGQCLP--FEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHN 197
Query: 71 ---------EPTSAG--------PCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNG 113
T G PC+P+PC NGGTC + GD + + C C GF G
Sbjct: 198 EVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPT----GD--VTHECACLPGFTG 251
Query: 114 IHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNC 154
+C+ NI++C CKNGG C D V Y+C CP E+ G+ C
Sbjct: 252 QNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYC 292
Score = 105 bits (263), Expect = 7e-23
Identities = 52/141 (36%), Positives = 71/141 (50%), Gaps = 31/141 (21%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C P+PC+NG C L G +SC+C G+ NCS ++ C +PC
Sbjct: 1147 DECSPSPCQNGATCTDYL--GGYSCKCVAGYHGVNCSEEID------------ECLSHPC 1192
Query: 84 HNGGTC-EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECE--VEP------CKNGGIC 134
NGGTC ++ Y+ C CPRG G+HC+ N+++C V+P C N G C
Sbjct: 1193 QNGGTCLDLPNTYK--------CSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTC 1244
Query: 135 TDLVANYSCECPGEFMGRNCQ 155
D V YSC CP F+G C+
Sbjct: 1245 VDQVGGYSCTCPPGFVGERCE 1265
Score = 105 bits (262), Expect = 9e-23
Identities = 57/158 (36%), Positives = 72/158 (45%), Gaps = 35/158 (22%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVV-EVASDE-----------EE 71
D C PNPC NGG C G+ + C+C GF C + E ASD +
Sbjct: 909 DDCRPNPCHNGGSCTDGI--NTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDS 966
Query: 72 PTSAGP--------------CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQ 117
T P CT + C NGGTC D + C CP GF G +CQ
Sbjct: 967 YTCTCPAGFSGIHCENNTPDCTESSCFNGGTCV-------DGINSFTCLCPPGFTGSYCQ 1019
Query: 118 HNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
H++NEC+ +PC +GG C D +Y C CP + G NCQ
Sbjct: 1020 HDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQ 1057
Score = 101 bits (251), Expect = 2e-21
Identities = 52/156 (33%), Positives = 72/156 (46%), Gaps = 33/156 (21%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNC-SSVVEVASDE--EEPTSA------- 75
C+ NPC NGG C + C C +GF+ PNC +++ E AS+ + T
Sbjct: 757 CESNPCVNGGTCKD--MTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYK 814
Query: 76 ----------------GPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHN 119
PC P+PC NGG C SE Y + C CP G+ G C+ +
Sbjct: 815 CNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYES-----FSCVCPTGWQGQTCEVD 869
Query: 120 INECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
INEC + PC++G C + Y C C + GRNC+
Sbjct: 870 INECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCE 905
Score = 99.4 bits (246), Expect = 7e-21
Identities = 49/128 (38%), Positives = 63/128 (49%), Gaps = 21/128 (16%)
Query: 29 NPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGT 88
NPCE+ G C+ L GSF C+C G+T P C E+ +E C NPC N T
Sbjct: 421 NPCEHAGKCINTL--GSFECQCLQGYTGPRC----EIDVNE--------CVSNPCQNDAT 466
Query: 89 CEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGE 148
C D + C C G+ G+HC+ N +EC PC + G C D + + CECP
Sbjct: 467 CL-------DQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTG 519
Query: 149 FMGRNCQY 156
F G CQY
Sbjct: 520 FTGHLCQY 527
Score = 99.4 bits (246), Expect = 7e-21
Identities = 47/135 (34%), Positives = 67/135 (49%), Gaps = 24/135 (17%)
Query: 31 CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCE 90
C++GG+C+ A + C C G+T C +V+ C+P+PC NG TC
Sbjct: 1116 CQHGGLCVD--AGNTHHCRCQAGYTGSYCEDLVD------------ECSPSPCQNGATCT 1161
Query: 91 ISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFM 150
D GY CKC G++G++C I+EC PC+NGG C DL Y C CP
Sbjct: 1162 -------DYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQ 1214
Query: 151 GRNCQYK---CSGPL 162
G +C+ C+ P+
Sbjct: 1215 GVHCEINVDDCNPPV 1229
Score = 97.4 bits (241), Expect = 2e-20
Identities = 48/129 (37%), Positives = 62/129 (48%), Gaps = 21/129 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C + C NGG C+ G+ SF+C CP GFT C V C PC +
Sbjct: 987 CTESSCFNGGTCVDGI--NSFTCLCPPGFTGSYCQHDVN------------ECDSQPCLH 1032
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GGTC+ D Y C CP+G+ G +CQ+ ++ C+ PCKNGG C Y CEC
Sbjct: 1033 GGTCQ-------DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCEC 1085
Query: 146 PGEFMGRNC 154
P + G C
Sbjct: 1086 PSGWTGLYC 1094
Score = 97.1 bits (240), Expect = 3e-20
Identities = 57/205 (27%), Positives = 79/205 (38%), Gaps = 78/205 (38%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
CD PC +GG C G GS+ C CP G+T PNC ++V C +PC N
Sbjct: 1025 CDSQPCLHGGTCQDGC--GSYRCTCPQGYTGPNCQNLVHW------------CDSSPCKN 1070
Query: 86 GG---------------------------TCEISEAYRG--------------DTFIGYV 104
GG +CE++ +G D +
Sbjct: 1071 GGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHH 1130
Query: 105 CKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ--------- 155
C+C G+ G +C+ ++EC PC+NG CTD + YSC+C + G NC
Sbjct: 1131 CRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSH 1190
Query: 156 --------------YKCSGPLGIEG 166
YKCS P G +G
Sbjct: 1191 PCQNGGTCLDLPNTYKCSCPRGTQG 1215
Score = 95.1 bits (235), Expect = 1e-19
Identities = 48/132 (36%), Positives = 63/132 (47%), Gaps = 23/132 (17%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C NPC NGG C L + C CP G++ +C A PC NPC N
Sbjct: 106 CLTNPCRNGGTC-DLLTLTEYKCRCPPGWSGKSCQQ-------------ADPCASNPCAN 151
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEP--CKNGGICTDLVANYSC 143
GG C EA Y+C CP F+G C+ ++NEC +P C++GG C + V +Y C
Sbjct: 152 GGQCLPFEA-------SYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRC 204
Query: 144 ECPGEFMGRNCQ 155
C G NC+
Sbjct: 205 VCRATHTGPNCE 216
Score = 93.6 bits (231), Expect = 4e-19
Identities = 47/130 (36%), Positives = 65/130 (50%), Gaps = 19/130 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C P+PC NGG C SFSC CP G+ C EV +E C +PC +
Sbjct: 833 CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTC----EVDINE--------CVLSPCRH 880
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G +C+ +T GY C C G++G +C+ +I++C PC NGG CTD + C+C
Sbjct: 881 GASCQ-------NTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDC 933
Query: 146 PGEFMGRNCQ 155
F G C+
Sbjct: 934 LPGFRGTFCE 943
Score = 93.2 bits (230), Expect = 5e-19
Identities = 49/132 (37%), Positives = 66/132 (50%), Gaps = 22/132 (16%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C PC+NG CL G +++C C +G+T +C EV DE C P+PC
Sbjct: 530 DECASTPCKNGAKCLDG--PNTYTCVCTEGYTGTHC----EVDIDE--------CDPDPC 575
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
H G +C+ D + C C G+ G HC+ NINEC +PC++GG C D Y C
Sbjct: 576 HYG-SCK-------DGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLC 627
Query: 144 ECPGEFMGRNCQ 155
C G NC+
Sbjct: 628 FCLKGTTGPNCE 639
Score = 93.2 bits (230), Expect = 5e-19
Identities = 51/144 (35%), Positives = 68/144 (47%), Gaps = 22/144 (15%)
Query: 22 KGDI--CDPNPCENGGI--CLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGP 77
+GD+ C NPC+ G C+ + D F CEC G T C SV+
Sbjct: 1265 EGDVNECLSNPCDARGTQNCVQRVND--FHCECRAGHTGRRCESVIN------------G 1310
Query: 78 CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDL 137
C PC NGGTC ++ +T G++CKCP GF G C+++ C C NGG C
Sbjct: 1311 CKGKPCKNGGTCAVAS----NTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISG 1366
Query: 138 VANYSCECPGEFMGRNCQYKCSGP 161
+ +C C G F G CQ+ S P
Sbjct: 1367 PRSPTCLCLGPFTGPECQFPASSP 1390
Score = 92.8 bits (229), Expect = 6e-19
Identities = 54/156 (34%), Positives = 73/156 (46%), Gaps = 29/156 (18%)
Query: 26 CDPNPCENGGIC----LPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
C PC+N G C G+AD ++C C GF+ P C + ++ A C N
Sbjct: 63 CLSTPCKNAGTCHVVDRRGVAD--YACSCALGFSGPLCLTPLDNA-----------CLTN 109
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC NGGTC++ T Y C+CP G++G CQ + C PC NGG C A+Y
Sbjct: 110 PCRNGGTCDLL------TLTEYKCRCPPGWSGKSCQQ-ADPCASNPCANGGQCLPFEASY 162
Query: 142 SCECPGEFMGRNCQY---KCSGPLGI--EGGIISNQ 172
C CP F G C+ +C G+ GG N+
Sbjct: 163 ICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNE 198
Score = 89.4 bits (220), Expect = 7e-18
Identities = 46/131 (35%), Positives = 62/131 (47%), Gaps = 19/131 (14%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C N C+NGG C+ G+ +++C CP +T C+ V+ PN C
Sbjct: 259 DDCPGNNCKNGGACVDGV--NTYNCRCPPEWTGQYCTEDVDECQ----------LMPNAC 306
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGGTC +T GY C C G+ G C NI++C C +G C D VA++ C
Sbjct: 307 QNGGTCH-------NTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYC 359
Query: 144 ECPGEFMGRNC 154
ECP G C
Sbjct: 360 ECPHGRTGLLC 370
Score = 89.0 bits (219), Expect = 9e-18
Identities = 49/142 (34%), Positives = 64/142 (45%), Gaps = 15/142 (10%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C +PC+NGG CL ++ C CP G +C V+ + +P S P C
Sbjct: 1185 DECLSHPCQNGGTCLD--LPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP----KC 1238
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGI--CTDLVANY 141
N GTC D GY C CP GF G C+ ++NEC PC G C V ++
Sbjct: 1239 FNNGTCV-------DQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDF 1291
Query: 142 SCECPGEFMGRNCQYKCSGPLG 163
CEC GR C+ +G G
Sbjct: 1292 HCECRAGHTGRRCESVINGCKG 1313
Score = 84.7 bits (208), Expect = 2e-16
Identities = 45/129 (34%), Positives = 58/129 (44%), Gaps = 22/129 (17%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PC +GG C D ++ C C G T PNC E+ D+ C +PC +
Sbjct: 607 CSSQPCRHGGTCQD--RDNAYLCFCLKGTTGPNC----EINLDD--------CASSPC-D 651
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GTC D GY C C G+ G C NI+EC PC NGG C D + ++C C
Sbjct: 652 SGTCL-------DKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRC 704
Query: 146 PGEFMGRNC 154
P + C
Sbjct: 705 PEGYHDPTC 713
Score = 80.1 bits (196), Expect = 4e-15
Identities = 46/127 (36%), Positives = 60/127 (47%), Gaps = 20/127 (15%)
Query: 31 CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCE 90
C NGG C A+G+ +C C F P C ++P PC PC N GTC
Sbjct: 31 CLNGGKC--EAANGTEACVCGGAFVGPRC----------QDPN---PCLSTPCKNAGTCH 75
Query: 91 ISEAYRGDTFIGYVCKCPRGFNGIHCQHNI-NECEVEPCKNGGICTDL-VANYSCECPGE 148
+ + RG Y C C GF+G C + N C PC+NGG C L + Y C CP
Sbjct: 76 VVDR-RG--VADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPG 132
Query: 149 FMGRNCQ 155
+ G++CQ
Sbjct: 133 WSGKSCQ 139
Score = 67.0 bits (162), Expect = 4e-11
Identities = 38/129 (29%), Positives = 52/129 (40%), Gaps = 24/129 (18%)
Query: 28 PNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGG 87
PN C+NGG C G ++C C +G+T +CS ++ C C +G
Sbjct: 303 PNACQNGGTCHN--THGGYNCVCVNGWTGEDCSENID------------DCASAACFHGA 348
Query: 88 TCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYS--CEC 145
TC D + C+CP G G+ C N + C PC G C N C C
Sbjct: 349 TCH-------DRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGKAICTC 400
Query: 146 PGEFMGRNC 154
P + G C
Sbjct: 401 PSGYTGPAC 409
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/120 (30%), Positives = 45/120 (37%), Gaps = 34/120 (28%)
Query: 26 CDPNPCENGGIC-LPGLADGSFSCECPDGFTDPNCSSVVEVA------------SDEEEP 72
C PC+NGG C + F C+CP GF C + S P
Sbjct: 1311 CKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSP 1370
Query: 73 T---------------SAGPCTP-NPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHC 116
T ++ PC NPC+N GTCE + F Y C CP FNG+ C
Sbjct: 1371 TCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSE---SPF--YRCLCPAKFNGLLC 1425
Score = 34.3 bits (77), Expect = 0.26
Identities = 38/136 (27%), Positives = 49/136 (36%), Gaps = 25/136 (18%)
Query: 29 NPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGT 88
NPC N G C P + C CP F C + D AG P P
Sbjct: 1395 NPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHIL-----DYSFGGGAGRDIPPPLIE-EA 1448
Query: 89 CEISEAYR--GDTFIGYVCK---CPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
CE+ E G+ C C G++G C N N +P KN CT S
Sbjct: 1449 CELPECQEDAGNKVCSLQCNNHAC--GWDGGDCSLNFN----DPWKN---CTQ-----SL 1494
Query: 144 ECPGEFMGRNCQYKCS 159
+C F +C +C+
Sbjct: 1495 QCWKYFSDGHCDSQCN 1510
Score = 32.0 bits (71), Expect = 1.3
Identities = 13/30 (43%), Positives = 15/30 (50%)
Query: 126 EPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
E C NGG C +C C G F+G CQ
Sbjct: 29 ETCLNGGKCEAANGTEACVCGGAFVGPRCQ 58
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 108 bits (270), Expect = 1e-23
Identities = 55/125 (44%), Positives = 69/125 (55%), Gaps = 20/125 (16%)
Query: 30 PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTC 89
PC +GG CL GSF C+CP G+T P C E P A PC P+PC NGGTC
Sbjct: 167 PCRHGGTCLN--TPGSFRCQCPAGYTGPLC----------ENP--AVPCAPSPCRNGGTC 212
Query: 90 EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEF 149
S GD + Y C C GF G +C+ N+++C C NGG C D V Y+C+CP E+
Sbjct: 213 RQS----GD--LTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVNTYNCQCPPEW 266
Query: 150 MGRNC 154
G+ C
Sbjct: 267 TGQFC 271
Score = 107 bits (267), Expect = 2e-23
Identities = 57/148 (38%), Positives = 73/148 (49%), Gaps = 25/148 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
CDPNPC NGG C G+ GSFSC C GF P C A D +E C NPC
Sbjct: 853 CDPNPCLNGGSCQDGV--GSFSCSCLPGFAGPRC------ARDVDE------CLSNPC-G 897
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GTC D + C CP G+ G HC+ ++ +C C NGG C D V ++SC C
Sbjct: 898 PGTCT-------DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLC 950
Query: 146 PGEFMGRNCQYK---CSGPLGIEGGIIS 170
+ G +CQ++ C + GG+ S
Sbjct: 951 RPGYTGAHCQHEADPCLSRPCLHGGVCS 978
Score = 100 bits (248), Expect = 4e-21
Identities = 48/125 (38%), Positives = 67/125 (53%), Gaps = 21/125 (16%)
Query: 31 CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTCE 90
C+ GG C+ D S C CP+G T +C V+ PC PC +GGTC
Sbjct: 1055 CQAGGQCVD--EDSSHYCVCPEGRTGSHCEQEVD------------PCLAQPCQHGGTCR 1100
Query: 91 ISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFM 150
Y G GY+C+C G+NG +C+ +++EC +PC++GG C DLVA Y C CP +
Sbjct: 1101 ---GYMG----GYMCECLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTL 1153
Query: 151 GRNCQ 155
G C+
Sbjct: 1154 GVLCE 1158
Score = 99.0 bits (245), Expect = 9e-21
Identities = 48/127 (37%), Positives = 60/127 (47%), Gaps = 21/127 (16%)
Query: 29 NPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGT 88
NPCE+ G C+ GSF C+C G+T P C T C PC N T
Sbjct: 400 NPCEHLGRCVN--TQGSFLCQCGRGYTGPRCE------------TDVNECLSGPCRNQAT 445
Query: 89 CEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGE 148
C D + C C GF G +C+ +I+EC+ PC NGG+C D V +SC CP
Sbjct: 446 CL-------DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSG 498
Query: 149 FMGRNCQ 155
F G CQ
Sbjct: 499 FSGSTCQ 505
Score = 96.3 bits (238), Expect = 6e-20
Identities = 49/133 (36%), Positives = 64/133 (48%), Gaps = 24/133 (18%)
Query: 24 DICDPNPCENGGICLPGLADG-SFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNP 82
D C+ PC GG C +DG F C CP G C + PCTPNP
Sbjct: 736 DACESQPCRAGGTCS---SDGMGFHCTCPPGVQGRQCELL-------------SPCTPNP 779
Query: 83 CHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECE-VEPCKNGGICTDLVANY 141
C +GG CE + VC CP+G+ G CQ +++EC PC GICT+L ++
Sbjct: 780 CEHGGRCESAPGQLP------VCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSF 833
Query: 142 SCECPGEFMGRNC 154
SC C G + G +C
Sbjct: 834 SCTCHGGYTGPSC 846
Score = 95.9 bits (237), Expect = 7e-20
Identities = 44/135 (32%), Positives = 66/135 (48%), Gaps = 22/135 (16%)
Query: 24 DICDPNPCENGGICLPGLADGS--FSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
D C PC G+C + G+ FSC CP GF P+CS PC +
Sbjct: 80 DPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSL-------------PDPCLSS 126
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEV-EPCKNGGICTDLVAN 140
PC +G C + R ++C CP G+ G C+ +++EC V EPC++GG C + +
Sbjct: 127 PCAHGARCSVGPDGR------FLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPGS 180
Query: 141 YSCECPGEFMGRNCQ 155
+ C+CP + G C+
Sbjct: 181 FRCQCPAGYTGPLCE 195
Score = 94.4 bits (233), Expect = 2e-19
Identities = 50/158 (31%), Positives = 69/158 (43%), Gaps = 36/158 (22%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS-SVVEVASDE--------EEPT- 73
D C +PC NGG+C + FSC CP GF+ C V E AS ++P
Sbjct: 471 DECQSSPCVNGGVCKDRV--NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDG 528
Query: 74 ----------------SAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQ 117
+ C+P+PCH+G D + C C G+ G C+
Sbjct: 529 YECRCAEGFEGTLCDRNVDDCSPDPCHHGRCV--------DGIASFSCACAPGYTGTRCE 580
Query: 118 HNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
++EC +PC++GG C DLV Y C CP G NC+
Sbjct: 581 SQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCE 618
Score = 92.4 bits (228), Expect = 8e-19
Identities = 53/148 (35%), Positives = 70/148 (47%), Gaps = 28/148 (18%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C P+PC +G C+ G+A SFSC C G+T C S V+ C PC
Sbjct: 547 DDCSPDPCHHGR-CVDGIA--SFSCACAPGYTGTRCESQVD------------ECRSQPC 591
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
+GG C D Y+C+CP G G++C+ NI++C PC G+C D + Y C
Sbjct: 592 RHGGKCL-------DLVDKYLCRCPSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDC 643
Query: 144 ECPGEFMGRNCQYK----CSGPLGIEGG 167
C F G C + S P G EGG
Sbjct: 644 VCQPGFTGPLCNVEINECASSPCG-EGG 670
Score = 90.9 bits (224), Expect = 2e-18
Identities = 49/129 (37%), Positives = 59/129 (45%), Gaps = 21/129 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PC N CL + G F+C C GFT C EV DE C +PC N
Sbjct: 435 CLSGPCRNQATCLDRI--GQFTCICMAGFTGTYC----EVDIDE--------CQSSPCVN 480
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C+ D G+ C CP GF+G CQ +++EC PC+NG C D Y C C
Sbjct: 481 GGVCK-------DRVNGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRC 533
Query: 146 PGEFMGRNC 154
F G C
Sbjct: 534 AEGFEGTLC 542
Score = 84.7 bits (208), Expect = 2e-16
Identities = 44/131 (33%), Positives = 63/131 (48%), Gaps = 19/131 (14%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C + C NGG C+ G+ +++C+CP +T C+ V+ + PN C
Sbjct: 238 DDCPGHRCLNGGTCVDGV--NTYNCQCPPEWTGQFCTEDVDECQLQ----------PNAC 285
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
HNGGTC +T G+ C C G+ G C NI++C C +G C D VA++ C
Sbjct: 286 HNGGTCF-------NTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYC 338
Query: 144 ECPGEFMGRNC 154
CP G C
Sbjct: 339 ACPMGKTGLLC 349
Score = 84.7 bits (208), Expect = 2e-16
Identities = 45/132 (34%), Positives = 59/132 (44%), Gaps = 23/132 (17%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C P+ C NGG C+ G+ SFSC C G+T +C A PC PC +
Sbjct: 928 CSPSSCFNGGTCVDGV--NSFSCLCRPGYTGAHCQH------------EADPCLSRPCLH 973
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C + G+ C C F G CQ ++ C +PC+NGG C A C C
Sbjct: 974 GGVCSAAHP-------GFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGA--YCLC 1024
Query: 146 PGEFMGRNCQYK 157
P + GR C +
Sbjct: 1025 PPGWSGRLCDIR 1036
Score = 84.3 bits (207), Expect = 2e-16
Identities = 45/131 (34%), Positives = 63/131 (48%), Gaps = 22/131 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C P+PC NGG C D ++ C C GF NC EV D+ C + C N
Sbjct: 201 CAPSPCRNGGTCRQS-GDLTYDCACLPGFEGQNC----EVNVDD--------CPGHRCLN 247
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEP--CKNGGICTDLVANYSC 143
GGTC D Y C+CP + G C +++EC+++P C NGG C + + +SC
Sbjct: 248 GGTCV-------DGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSC 300
Query: 144 ECPGEFMGRNC 154
C + G +C
Sbjct: 301 VCVNGWTGESC 311
Score = 82.4 bits (202), Expect = 8e-16
Identities = 46/173 (26%), Positives = 65/173 (37%), Gaps = 53/173 (30%)
Query: 22 KGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
+ D C PC +GG+C A F C C + FT P C ++V+ C+
Sbjct: 962 EADPCLSRPCLHGGVC--SAAHPGFRCTCLESFTGPQCQTLVDW------------CSRQ 1007
Query: 82 PCHNGGTCEISEAY---------------------------------------RGDTFIG 102
PC NGG C + AY D
Sbjct: 1008 PCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSS 1067
Query: 103 YVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
+ C CP G G HC+ ++ C +PC++GG C + Y CEC + G NC+
Sbjct: 1068 HYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCECLPGYNGDNCE 1120
Score = 82.4 bits (202), Expect = 8e-16
Identities = 43/139 (30%), Positives = 60/139 (43%), Gaps = 28/139 (20%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C PC++GG C + G + CEC G+ NC V+ C PC
Sbjct: 1086 DPCLAQPCQHGGTCRGYM--GGYMCECLPGYNGDNCEDDVD------------ECASQPC 1131
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEP-------CKNGGICTD 136
+GG+C D Y+C CP G G+ C+ N ++C P C + G C D
Sbjct: 1132 QHGGSCI-------DLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVD 1184
Query: 137 LVANYSCECPGEFMGRNCQ 155
LV + C CP + G C+
Sbjct: 1185 LVGGFRCTCPPGYTGLRCE 1203
Score = 71.2 bits (173), Expect = 2e-12
Identities = 38/132 (28%), Positives = 55/132 (41%), Gaps = 24/132 (18%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C +PC GG C+ G + F C CP G P C + PC PC +
Sbjct: 661 CASSPCGEGGSCVDG--ENGFRCLCPPGSLPPLCLP------------PSHPCAHEPCSH 706
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI--NECEVEPCKNGGICTDLVANYSC 143
G + +R C C G++G C ++ + CE +PC+ GG C+ + C
Sbjct: 707 GICYDAPGGFR--------CVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHC 758
Query: 144 ECPGEFMGRNCQ 155
CP GR C+
Sbjct: 759 TCPPGVQGRQCE 770
Score = 66.2 bits (160), Expect = 6e-11
Identities = 40/144 (27%), Positives = 58/144 (40%), Gaps = 30/144 (20%)
Query: 24 DICDPNP-------CENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAG 76
D C P P C + G C+ + G F C CP G+T C + +
Sbjct: 1162 DDCGPGPPLDSGPRCLHNGTCVDLV--GGFRCTCPPGYTGLRCEADIN------------ 1207
Query: 77 PCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTD 136
C CH T + + G G+ C C GF+G CQ ++ CE +PC++GG C
Sbjct: 1208 ECRSGACHAAHTRDCLQDPGG----GFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRP 1263
Query: 137 LVA-----NYSCECPGEFMGRNCQ 155
++C C F G C+
Sbjct: 1264 SPGPGGGLTFTCHCAQPFWGPRCE 1287
Score = 62.0 bits (149), Expect = 1e-09
Identities = 42/146 (28%), Positives = 53/146 (36%), Gaps = 26/146 (17%)
Query: 27 DPNPCENGGI-------CL--PGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGP 77
D N C +G CL PG G F C C GF+ P C +V+ P
Sbjct: 1205 DINECRSGACHAAHTRDCLQDPG---GGFRCLCHAGFSGPRCQTVLS------------P 1249
Query: 78 CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDL 137
C PC +GG C S G + + C C + F G C+ C C G C
Sbjct: 1250 CESQPCQHGGQCRPSPGPGGG--LTFTCHCAQPFWGPRCERVARSCRELQCPVGVPCQQT 1307
Query: 138 VANYSCECPGEFMGRNCQYKCSGPLG 163
C CP G +C+ P G
Sbjct: 1308 PRGPRCACPPGLSGPSCRSFPGSPPG 1333
Score = 59.3 bits (142), Expect = 7e-09
Identities = 39/149 (26%), Positives = 54/149 (36%), Gaps = 32/149 (21%)
Query: 26 CDPNPCENGGICLPGLADG---SFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNP 82
C+ PC++GG C P G +F+C C F P C V + + P PC P
Sbjct: 1250 CESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGV-PCQQTP 1308
Query: 83 CHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQH--------NINECEVEPCKNGGIC 134
RG C CP G +G C+ + C PC +GG C
Sbjct: 1309 -------------RGPR-----CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSC 1350
Query: 135 --TDLVANYSCECPGEFMGRNCQYKCSGP 161
L + C C + G C+ + P
Sbjct: 1351 RPAPLAPFFRCACAQGWTGPRCEAPAAAP 1379
Score = 45.8 bits (107), Expect = 9e-05
Identities = 33/118 (27%), Positives = 42/118 (35%), Gaps = 18/118 (15%)
Query: 16 GVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSA 75
G P C PC +GG C P F C C G+T P C + EEP
Sbjct: 1329 GSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPR-- 1386
Query: 76 GPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPR-GFNGIHCQHNI----NECEVEPC 128
C C +A RGD C P G++G C ++ +CE C
Sbjct: 1387 --CPRAAC---------QAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQC 1433
Score = 33.9 bits (76), Expect = 0.34
Identities = 19/44 (43%), Positives = 24/44 (54%), Gaps = 4/44 (9%)
Query: 127 PCKNGGICTDLVA-NYSCECPGEFMGRNCQYK--C-SGPLGIEG 166
PC NGG CT L + +C CP ++G CQ + C SGP G
Sbjct: 48 PCANGGRCTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRG 91
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 107 bits (267), Expect = 2e-23
Identities = 49/129 (37%), Positives = 65/129 (50%), Gaps = 20/129 (15%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PC NGG C DG +SC CP G++ NC ++ C+ +PC N
Sbjct: 370 CADGPCFNGGRCSDS-PDGGYSCRCPVGYSGFNCEKKIDY------------CSSSPCSN 416
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G C D Y+C+C GF+G HC N+++C PC NGG C D V ++SC C
Sbjct: 417 GAKCV-------DLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTC 469
Query: 146 PGEFMGRNC 154
P + GRNC
Sbjct: 470 PPGYTGRNC 478
Score = 90.1 bits (222), Expect = 4e-18
Identities = 49/129 (37%), Positives = 61/129 (47%), Gaps = 21/129 (16%)
Query: 30 PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTC 89
PC+NG C GS++C C G+T C E+ DE C P+PC NGG+C
Sbjct: 297 PCKNGATCT-NTGQGSYTCSCRPGYTGATC----ELGIDE--------CDPSPCKNGGSC 343
Query: 90 EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLV-ANYSCECPGE 148
D Y C CP GF G C+ + C PC NGG C+D YSC CP
Sbjct: 344 T-------DLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCRCPVG 396
Query: 149 FMGRNCQYK 157
+ G NC+ K
Sbjct: 397 YSGFNCEKK 405
Score = 84.3 bits (207), Expect = 2e-16
Identities = 45/134 (33%), Positives = 62/134 (46%), Gaps = 19/134 (14%)
Query: 22 KGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
+G CD C CL G + C C +G+ C+ + + +
Sbjct: 250 QGRYCDE--CIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHK----------- 296
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC NG TC + +G Y C C G+ G C+ I+EC+ PCKNGG CTDL +Y
Sbjct: 297 PCKNGATC--TNTGQGS----YTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY 350
Query: 142 SCECPGEFMGRNCQ 155
SC CP F G+ C+
Sbjct: 351 SCTCPPGFYGKICE 364
Score = 74.7 bits (182), Expect = 2e-13
Identities = 42/104 (40%), Positives = 50/104 (48%), Gaps = 21/104 (20%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C +PC NGG C G+ D FSC CP G+T NCS+ V C PC
Sbjct: 445 DDCASSPCANGGTCRDGVND--FSCTCPPGYTGRNCSAPVS------------RCEHAPC 490
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEP 127
HNG TC RG YVC+C RG+ G +CQ + E P
Sbjct: 491 HNGATCH----ERGHR---YVCECARGYGGPNCQFLLPELPPGP 527
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 106 bits (265), Expect = 4e-23
Identities = 50/131 (38%), Positives = 69/131 (52%), Gaps = 20/131 (15%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C +PC++GG C GL G + C C FT NC S + C PNPC
Sbjct: 4023 DACKRSPCQHGGSCT-GLPSGGYQCTCLSQFTGRNCESEITA------------CFPNPC 4069
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGG+C+ G+TFI C C G G+ C+ +INECE E C+NGG C ++ ++ C
Sbjct: 4070 RNGGSCDPI----GNTFI---CNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLC 4122
Query: 144 ECPGEFMGRNC 154
C ++G+ C
Sbjct: 4123 NCTPGYVGQYC 4133
Score = 58.2 bits (139), Expect = 2e-08
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 6/78 (7%)
Query: 78 CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDL 137
C +PC +GG+C G GY C C F G +C+ I C PC+NGG C +
Sbjct: 4025 CKRSPCQHGGSCT------GLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPI 4078
Query: 138 VANYSCECPGEFMGRNCQ 155
+ C C G C+
Sbjct: 4079 GNTFICNCKAGLTGVTCE 4096
Score = 29.6 bits (65), Expect = 6.3
Identities = 23/89 (25%), Positives = 31/89 (34%), Gaps = 13/89 (14%)
Query: 26 CDPNPCENG----GICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
C CE G L + S CP + + C+ + P S PC
Sbjct: 3748 CQEQHCEQGLSLDSHALMTYSTARISFVCPRFYRNVRCTCNGGLC-----PGSNDPCVEK 3802
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRG 110
PC C EA R ++C+CP G
Sbjct: 3803 PCPGDMQCVSYEASRRP----FLCQCPPG 3827
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 106 bits (264), Expect = 5e-23
Identities = 47/130 (36%), Positives = 63/130 (48%), Gaps = 21/130 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PC+NGG C G+ SF C+CP GF P C T+ PC C +
Sbjct: 315 CASQPCQNGGTCTHGI--NSFRCQCPAGFGGPTCE------------TAQSPCDTKECQH 360
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C++ VC C G+ G C+ ++++C +PC NGG C DLV NY+C C
Sbjct: 361 GGQCQVENG-------SAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLC 413
Query: 146 PGEFMGRNCQ 155
F G C+
Sbjct: 414 AEPFKGLRCE 423
Score = 100 bits (249), Expect = 3e-21
Identities = 51/132 (38%), Positives = 63/132 (47%), Gaps = 22/132 (16%)
Query: 25 ICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCH 84
+C PC NGG C A G + C CP FT +C E+ + C PCH
Sbjct: 583 LCSSGPCRNGGTCKE--AGGEYHCSCPYRFTGRHC----EIGKPDS-------CASGPCH 629
Query: 85 NGGTCEISEAYRGDTFIG-YVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGGTC +IG Y C CP GF+G HC+ + C PC NGG C D ++ C
Sbjct: 630 NGGTCF--------HYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFC 681
Query: 144 ECPGEFMGRNCQ 155
C +MGR CQ
Sbjct: 682 HCQAGYMGRRCQ 693
Score = 92.8 bits (229), Expect = 6e-19
Identities = 47/138 (34%), Positives = 66/138 (47%), Gaps = 21/138 (15%)
Query: 18 PQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGP 77
PQ + D C PC +GG C +A + C C G+ +C E+ DE
Sbjct: 749 PQCLEIDECRSQPCLHGGSCQDRVA--GYLCLCSTGYEGAHC----ELERDE-------- 794
Query: 78 CTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDL 137
C +PC NGG+C YVC+CP GF G+HC+ ++ C+ PC++GG C
Sbjct: 795 CRAHPCRNGGSCRNLPG-------AYVCRCPAGFVGVHCETEVDACDSSPCQHGGRCESG 847
Query: 138 VANYSCECPGEFMGRNCQ 155
Y C CP F G +C+
Sbjct: 848 GGAYLCVCPESFFGYHCE 865
Score = 91.7 bits (226), Expect = 1e-18
Identities = 52/136 (38%), Positives = 73/136 (53%), Gaps = 24/136 (17%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C P+PC NGG C+ + G+++C C + F C + D P + C PC
Sbjct: 389 DDCSPDPCLNGGSCVDLV--GNYTCLCAEPFKGLRCET-----GDHPVPDA---CLSAPC 438
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI-NECEVEPCKNGGICTDLVANYS 142
HNGGTC D GYVC+CP GF G+ C+ + ++CE C+NGG C L AN +
Sbjct: 439 HNGGTCV-------DADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRC--LGANTT 486
Query: 143 -CECPGEFMGRNCQYK 157
C+CP F G C+++
Sbjct: 487 LCQCPLGFFGLLCEFE 502
Score = 83.6 bits (205), Expect = 4e-16
Identities = 44/144 (30%), Positives = 62/144 (43%), Gaps = 25/144 (17%)
Query: 24 DICDPNPCENGGIC--LPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
D C +PC NGG C LPG ++ C CP GF +C + V+ C +
Sbjct: 793 DECRAHPCRNGGSCRNLPG----AYVCRCPAGFVGVHCETEVDA------------CDSS 836
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC +GG CE Y+C CP F G HC+ + C PC G C ++
Sbjct: 837 PCQHGGRCESGGG-------AYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGSH 889
Query: 142 SCECPGEFMGRNCQYKCSGPLGIE 165
SC C + G +C + P ++
Sbjct: 890 SCTCKVGYTGEDCAKELFPPTALK 913
Score = 73.6 bits (179), Expect = 4e-13
Identities = 31/74 (41%), Positives = 42/74 (56%), Gaps = 3/74 (4%)
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC NGG C I + G+ Y C C GF G C ++NEC +PC+NGG CT + ++
Sbjct: 277 PCLNGGKC-IDDCVTGNP--SYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSF 333
Query: 142 SCECPGEFMGRNCQ 155
C+CP F G C+
Sbjct: 334 RCQCPAGFGGPTCE 347
Score = 71.2 bits (173), Expect = 2e-12
Identities = 43/131 (32%), Positives = 58/131 (44%), Gaps = 26/131 (19%)
Query: 19 QFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPC 78
+ GK D C PC NGG C + G + C+CP GF+ +C E+A PC
Sbjct: 616 EIGKPDSCASGPCHNGGTCFHYI--GKYKCDCPPGFSGRHC----EIA--------PSPC 661
Query: 79 TPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKN-----GGI 133
+PC NGGTCE D + C C G+ G CQ ++ E K+ G
Sbjct: 662 FRSPCVNGGTCE-------DRDTDFFCHCQAGYMGRRCQAEVDCGPPEEVKHATLRFNGT 714
Query: 134 CTDLVANYSCE 144
VA Y+C+
Sbjct: 715 RLGAVALYACD 725
Score = 48.1 bits (113), Expect = 2e-05
Identities = 25/55 (45%), Positives = 32/55 (58%), Gaps = 8/55 (14%)
Query: 11 VGLSLGVPQFGKGDI------CDPNPCENGGICLPGLADGSFSCECPDGFTDPNC 59
V L+L +P+ G DI C NPC+NGG C+PG AD + SC+C GF C
Sbjct: 1290 VSLALQLPEHGSKDIGNVPGNCSENPCQNGGTCVPG-AD-AHSCDCGPGFKGRRC 1342
Score = 41.2 bits (95), Expect = 0.002
Identities = 15/36 (41%), Positives = 19/36 (52%)
Query: 123 CEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKC 158
C PC+NGG C +SC+C F GR C+ C
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELAC 1346
Score = 37.4 bits (85), Expect = 0.030
Identities = 21/70 (30%), Positives = 27/70 (38%), Gaps = 18/70 (25%)
Query: 76 GPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQ-----------HNINECE 124
G C+ NPC NGGTC + C C GF G C+ +E +
Sbjct: 1309 GNCSENPCQNGGTCVPGAD-------AHSCDCGPGFKGRRCELACIKVSRPCTRLFSETK 1361
Query: 125 VEPCKNGGIC 134
P GG+C
Sbjct: 1362 AFPVWEGGVC 1371
Score = 35.4 bits (80), Expect = 0.12
Identities = 17/44 (38%), Positives = 21/44 (47%), Gaps = 5/44 (11%)
Query: 116 CQHNINEC-EVEPCKNGGICTDLVA----NYSCECPGEFMGRNC 154
C H + C + PC NGG C D +Y+C C F GR C
Sbjct: 265 CGHTTSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRC 308
>gi|10835083 X-linked juvenile retinoschisis protein precursor [Homo
sapiens]
Length = 224
Score = 105 bits (263), Expect = 7e-23
Identities = 58/159 (36%), Positives = 89/159 (55%), Gaps = 3/159 (1%)
Query: 321 EPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQV 380
+PLG +SG + QIT S+ + + +W KARL+ QG AW S D SQWLQ+
Sbjct: 67 KPLGFESGEVTPDQITCSNPEQYVGW-YSSWTANKARLNSQGFGCAWLSKFQDSSQWLQI 125
Query: 381 DLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDND 440
DL ++GI+TQG D +++ Y + Y D +Y ++ ++VF GN D
Sbjct: 126 DLKEIKVISGILTQGRCDID--EWMTKYSVQYRTDERLNWIYYKDQTGNNRVFYGNSDRT 183
Query: 441 THRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEE 479
+ +N++ PPI +R IR++P W+ RI +R ELL C +
Sbjct: 184 STVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLECVSK 222
Score = 91.7 bits (226), Expect = 1e-18
Identities = 55/161 (34%), Positives = 83/161 (51%), Gaps = 5/161 (3%)
Query: 161 PLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINL 220
PLG E G ++ QIT S+ + + W ARLN +G AW + D W+QI+L
Sbjct: 68 PLGFESGEVTPDQITCSNPEQYVGWYSSWTANKARLNSQGFGCAWLSKFQDSSQWLQIDL 127
Query: 221 QRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGK-TWAMYKVKGTNEDMVFRGNIDNNT 279
+ ++G++TQG R E++ Y + Y D + W YK + T + VF GN D +
Sbjct: 128 KEIKVISGILTQG--RCDIDEWMTKYSVQYRTDERLNWIYYKDQ-TGNNRVFYGNSDRTS 184
Query: 280 PYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCS 320
N PPI ++++RL P +RMELL C +S C+
Sbjct: 185 TVQNLLRPPIISRFIRLIPLGWHVRIAIRMELLEC-VSKCA 224
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 105 bits (262), Expect = 9e-23
Identities = 48/131 (36%), Positives = 63/131 (48%), Gaps = 21/131 (16%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C P PC N G+C + G F CECP G+T C + C+ +PC
Sbjct: 1233 DECSPLPCLNNGVCKDLV--GEFICECPSGYTGQRCEENIN------------ECSSSPC 1278
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
N G C D GY C C +GF G+HC+ +NEC+ PC N +C D V + C
Sbjct: 1279 LNKGICV-------DGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLC 1331
Query: 144 ECPGEFMGRNC 154
+CP F+G C
Sbjct: 1332 KCPPGFLGTRC 1342
Score = 99.8 bits (247), Expect = 5e-21
Identities = 47/130 (36%), Positives = 61/130 (46%), Gaps = 21/130 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C NPC N +C + G F C+CP GF C V+ C PC N
Sbjct: 1311 CQSNPCLNNAVCEDQV--GGFLCKCPPGFLGTRCGKNVD------------ECLSQPCKN 1356
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G TC+ D + C C GF G HC+ NINEC+ PC+N C D + +YSC+C
Sbjct: 1357 GATCK-------DGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKC 1409
Query: 146 PGEFMGRNCQ 155
F G+ C+
Sbjct: 1410 QPGFSGKRCE 1419
Score = 97.1 bits (240), Expect = 3e-20
Identities = 49/130 (37%), Positives = 64/130 (49%), Gaps = 21/130 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C NPC N G C L G + C CP G+T C + ++ C+P PC N
Sbjct: 1197 CFFNPCHNSGTCQQ-LGRG-YVCLCPLGYTGLKCETDID------------ECSPLPCLN 1242
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
G C+ D ++C+CP G+ G C+ NINEC PC N GIC D VA Y C C
Sbjct: 1243 NGVCK-------DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTC 1295
Query: 146 PGEFMGRNCQ 155
F+G +C+
Sbjct: 1296 VKGFVGLHCE 1305
Score = 88.2 bits (217), Expect = 2e-17
Identities = 54/156 (34%), Positives = 68/156 (43%), Gaps = 36/156 (23%)
Query: 42 ADGSFSCECPDGFTDP--------NCSSVVEVASDEEE----PTSAG------------- 76
A +F CP T P CSS S EE P S G
Sbjct: 1135 AGKAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVF 1194
Query: 77 -PCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICT 135
C NPCHN GTC+ GYVC CP G+ G+ C+ +I+EC PC N G+C
Sbjct: 1195 HECFFNPCHNSGTCQ-------QLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCK 1247
Query: 136 DLVANYSCECPGEFMGRNCQ---YKCSGPLGIEGGI 168
DLV + CECP + G+ C+ +CS + GI
Sbjct: 1248 DLVGEFICECPSGYTGQRCEENINECSSSPCLNKGI 1283
Score = 60.8 bits (146), Expect = 3e-09
Identities = 42/128 (32%), Positives = 50/128 (39%), Gaps = 36/128 (28%)
Query: 30 PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGTC 89
PC+NGGIC +C CP+G+ C EEP PC NGG C
Sbjct: 3475 PCQNGGIC-----QRPNACSCPEGWMGRLC----------EEPICILPCL-----NGGRC 3514
Query: 90 EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCECPGEF 149
Y C CP G+ G C + C+ PC NGG C V C C +
Sbjct: 3515 ----------VAPYQCDCPPGWTGSRCHTAV--CQ-SPCLNGGKC---VRPNRCHCLSSW 3558
Query: 150 MGRNCQYK 157
G NC K
Sbjct: 3559 TGHNCSRK 3566
Score = 56.6 bits (135), Expect = 5e-08
Identities = 32/94 (34%), Positives = 37/94 (39%), Gaps = 21/94 (22%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C PC+NG C G SF C C GFT +C + C NPC
Sbjct: 1347 DECLSQPCKNGATCKDGA--NSFRCLCAAGFTGSHCE------------LNINECQSNPC 1392
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQ 117
N TC D Y CKC GF+G C+
Sbjct: 1393 RNQATCV-------DELNSYSCKCQPGFSGKRCE 1419
Score = 53.1 bits (126), Expect = 5e-07
Identities = 33/87 (37%), Positives = 40/87 (45%), Gaps = 18/87 (20%)
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC NGG C+ A C CP G+ G C+ I C + PC NGG C VA Y
Sbjct: 3475 PCQNGGICQRPNA----------CSCPEGWMGRLCEEPI--C-ILPCLNGGRC---VAPY 3518
Query: 142 SCECPGEFMGRNCQYK-CSGPLGIEGG 167
C+CP + G C C P + GG
Sbjct: 3519 QCDCPPGWTGSRCHTAVCQSPC-LNGG 3544
Score = 38.1 bits (87), Expect = 0.018
Identities = 22/76 (28%), Positives = 31/76 (40%), Gaps = 24/76 (31%)
Query: 18 PQFGKGDICDPN----PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPT 73
P+ G +C+ PC NGG C+ + C+CP G+T C + V
Sbjct: 3491 PEGWMGRLCEEPICILPCLNGGRCV-----APYQCDCPPGWTGSRCHTAV---------- 3535
Query: 74 SAGPCTPNPCHNGGTC 89
+PC NGG C
Sbjct: 3536 -----CQSPCLNGGKC 3546
Score = 35.4 bits (80), Expect = 0.12
Identities = 14/36 (38%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSS 61
C NPC N C+ L S+SC+C GF+ C +
Sbjct: 1387 CQSNPCRNQATCVDEL--NSYSCKCQPGFSGKRCET 1420
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 103 bits (257), Expect = 3e-22
Identities = 53/144 (36%), Positives = 69/144 (47%), Gaps = 21/144 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C PNPC NGG C+ + SF+C C +G+ P C+ + C+P+PC+N
Sbjct: 748 CLPNPCHNGGTCV--VNGESFTCVCKEGWEGPICAQ------------NTNDCSPHPCYN 793
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GTC GD + Y C+C GF G C+ NINEC+ PC G C D + Y C C
Sbjct: 794 SGTC-----VDGDNW--YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVC 846
Query: 146 PGEFMGRNCQYKCSGPLGIEGGII 169
P G CQ P G +I
Sbjct: 847 PPGHSGAKCQEVSGRPCITMGSVI 870
Score = 100 bits (250), Expect = 2e-21
Identities = 51/138 (36%), Positives = 68/138 (49%), Gaps = 21/138 (15%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C +PC N G C F CEC G+T P CS T+ C+PN C +
Sbjct: 340 CLSDPCHNRGSCKE--TSLGFECECSPGWTGPTCS------------TNIDDCSPNNCSH 385
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GGTC+ D G+ C CP + G CQ + NECE +PC N C +L+A+Y C+C
Sbjct: 386 GGTCQ-------DLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCDC 438
Query: 146 PGEFMGRNCQYKCSGPLG 163
+MG+NC + LG
Sbjct: 439 LPGWMGQNCDININDCLG 456
Score = 96.3 bits (238), Expect = 6e-20
Identities = 45/129 (34%), Positives = 59/129 (45%), Gaps = 21/129 (16%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C+ NPC NGG C+ G+ S+ C C DG+ C T+ C+ NPCHN
Sbjct: 633 CESNPCRNGGTCIDGV--NSYKCICSDGWEGAYCE------------TNINDCSQNPCHN 678
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GGTC D + C C G+ G C ++C+ C NGG C D + C C
Sbjct: 679 GGTCR-------DLVNDFYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFKCMC 731
Query: 146 PGEFMGRNC 154
PG + G C
Sbjct: 732 PGGWEGTTC 740
Score = 95.1 bits (235), Expect = 1e-19
Identities = 46/147 (31%), Positives = 66/147 (44%), Gaps = 23/147 (15%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS---------------SVVEVASD 68
D C+PNPC+NG C +D + C+CP+ + NCS S +
Sbjct: 527 DYCEPNPCQNGAQCYNRASD--YFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMAS 584
Query: 69 EEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPC 128
+ P + N C G C+ + + C C +GF G +C NIN+CE PC
Sbjct: 585 NDTPEGVRYISSNVCGPHGKCKSQSGGK------FTCDCNKGFTGTYCHENINDCESNPC 638
Query: 129 KNGGICTDLVANYSCECPGEFMGRNCQ 155
+NGG C D V +Y C C + G C+
Sbjct: 639 RNGGTCIDGVNSYKCICSDGWEGAYCE 665
Score = 87.0 bits (214), Expect = 3e-17
Identities = 47/140 (33%), Positives = 69/140 (49%), Gaps = 27/140 (19%)
Query: 23 GDICDPN------PCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAG 76
G CD N C+N C L +G + C CP G+ +C ++
Sbjct: 444 GQNCDININDCLGQCQNDASCRD-LVNG-YRCICPPGYAGDHCERDID------------ 489
Query: 77 PCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTD 136
C NPC NGG C+ +E R + C CP GF+G CQ +I+ CE PC+NG C +
Sbjct: 490 ECASNPCLNGGHCQ-NEINR------FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYN 542
Query: 137 LVANYSCECPGEFMGRNCQY 156
++Y C+CP ++ G+NC +
Sbjct: 543 RASDYFCKCPEDYEGKNCSH 562
Score = 83.6 bits (205), Expect = 4e-16
Identities = 51/162 (31%), Positives = 64/162 (39%), Gaps = 44/162 (27%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C PN C +GG C L +G F C CP +T C A C PC
Sbjct: 376 DDCSPNNCSHGGTC-QDLVNG-FKCVCPPQWTGKTCQ------------LDANECEAKPC 421
Query: 84 HN--------------------GGTCEIS----------EAYRGDTFIGYVCKCPRGFNG 113
N G C+I+ +A D GY C CP G+ G
Sbjct: 422 VNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAG 481
Query: 114 IHCQHNINECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQ 155
HC+ +I+EC PC NGG C + + + C CP F G CQ
Sbjct: 482 DHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQ 523
Score = 63.2 bits (152), Expect = 5e-10
Identities = 35/131 (26%), Positives = 53/131 (40%), Gaps = 22/131 (16%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C P+P C+ G+ + + C C + C + T PC
Sbjct: 263 DKCIPHPG-----CVHGICNEPWQCLCETNWGGQLCDKDLNYCG-----------THQPC 306
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSC 143
NGGTC + + Y C CP G++G +C+ + C +PC N G C + + C
Sbjct: 307 LNGGTCSNTGPDK------YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFEC 360
Query: 144 ECPGEFMGRNC 154
EC + G C
Sbjct: 361 ECSPGWTGPTC 371
Score = 46.2 bits (108), Expect = 7e-05
Identities = 35/132 (26%), Positives = 51/132 (38%), Gaps = 37/132 (28%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C P ++G LPG C C G+ C C P+P
Sbjct: 238 CSP---KHGSCKLPG------DCRCQYGWQGLYCDK----------------CIPHPGCV 272
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEV-EPCKNGGICTDLVAN-YSC 143
G C +E ++ C C + G C ++N C +PC NGG C++ + Y C
Sbjct: 273 HGIC--NEPWQ--------CLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQC 322
Query: 144 ECPGEFMGRNCQ 155
CP + G NC+
Sbjct: 323 SCPEGYSGPNCE 334
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 103 bits (257), Expect = 3e-22
Identities = 52/145 (35%), Positives = 64/145 (44%), Gaps = 21/145 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
CD NPC NGG C SF C CP GF C S C PC N
Sbjct: 278 CDGNPCANGGSCSE--TPRSFECTCPRGFYGLRCE------------VSGVTCADGPCFN 323
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C D Y+C CP GF G +C+ ++ C ++PC+NGG+C DL C C
Sbjct: 324 GGLC----VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
Query: 146 PGEFMGRNCQY---KCSGPLGIEGG 167
F G C++ C+G GG
Sbjct: 380 RAGFAGPRCEHDLDDCAGRACANGG 404
Score = 92.4 bits (228), Expect = 8e-19
Identities = 46/135 (34%), Positives = 64/135 (47%), Gaps = 22/135 (16%)
Query: 23 GDICDPNPCENGGICLPGL-ADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
G C PC NGG+C+ G D ++ C CP GF NC V+ C+
Sbjct: 313 GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD------------RCSLQ 360
Query: 82 PCHNGGTC-EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVAN 140
PC NGG C ++ A R C+C GF G C+H++++C C NGG C +
Sbjct: 361 PCRNGGLCLDLGHALR--------CRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGA 412
Query: 141 YSCECPGEFMGRNCQ 155
+ C C F GR+C+
Sbjct: 413 HRCSCALGFGGRDCR 427
Score = 52.8 bits (125), Expect = 7e-07
Identities = 30/98 (30%), Positives = 38/98 (38%), Gaps = 21/98 (21%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C C NGG C+ G G+ C C GF +C A PC PC
Sbjct: 393 DDCAGRACANGGTCVEG--GGAHRCSCALGFGGRDCRE------------RADPCAARPC 438
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNIN 121
+GG C F G VC C G+ G C+ ++
Sbjct: 439 AHGGRCYAH-------FSGLVCACAPGYMGARCEFPVH 469
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 103 bits (257), Expect = 3e-22
Identities = 52/145 (35%), Positives = 64/145 (44%), Gaps = 21/145 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
CD NPC NGG C SF C CP GF C S C PC N
Sbjct: 278 CDGNPCANGGSCSE--TPRSFECTCPRGFYGLRCE------------VSGVTCADGPCFN 323
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C D Y+C CP GF G +C+ ++ C ++PC+NGG+C DL C C
Sbjct: 324 GGLC----VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
Query: 146 PGEFMGRNCQY---KCSGPLGIEGG 167
F G C++ C+G GG
Sbjct: 380 RAGFAGPRCEHDLDDCAGRACANGG 404
Score = 92.4 bits (228), Expect = 8e-19
Identities = 46/135 (34%), Positives = 64/135 (47%), Gaps = 22/135 (16%)
Query: 23 GDICDPNPCENGGICLPGL-ADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
G C PC NGG+C+ G D ++ C CP GF NC V+ C+
Sbjct: 313 GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD------------RCSLQ 360
Query: 82 PCHNGGTC-EISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVAN 140
PC NGG C ++ A R C+C GF G C+H++++C C NGG C +
Sbjct: 361 PCRNGGLCLDLGHALR--------CRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGA 412
Query: 141 YSCECPGEFMGRNCQ 155
+ C C F GR+C+
Sbjct: 413 HRCSCALGFGGRDCR 427
Score = 52.8 bits (125), Expect = 7e-07
Identities = 30/98 (30%), Positives = 38/98 (38%), Gaps = 21/98 (21%)
Query: 24 DICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPC 83
D C C NGG C+ G G+ C C GF +C A PC PC
Sbjct: 393 DDCAGRACANGGTCVEG--GGAHRCSCALGFGGRDCRE------------RADPCAARPC 438
Query: 84 HNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNIN 121
+GG C F G VC C G+ G C+ ++
Sbjct: 439 AHGGRCYAH-------FSGLVCACAPGYMGARCEFPVH 469
>gi|27735143 discoidin, CUB and LCCL domain containing 1 [Homo
sapiens]
Length = 539
Score = 103 bits (257), Expect = 3e-22
Identities = 59/166 (35%), Positives = 92/166 (55%), Gaps = 12/166 (7%)
Query: 317 SGCSEPLGMKSGHIQDYQITASSIFRTLNM--DMFTWEPRKARLDKQGKVNAWTSGHNDQ 374
+GCS L + D QI ASS ++++N D W P +ARL QG +W SG +
Sbjct: 253 NGCSRSLSFEP----DGQIRASSSWQSVNESGDQVHWSPGQARLQDQGP--SWASGDSSN 306
Query: 375 S----QWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKD 430
+ +WL++DL K+TGI T G+ +V S+ + + N+ W Y+ ++
Sbjct: 307 NHKPREWLEIDLGEKKKITGIRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEE 366
Query: 431 KVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGC 476
KVFQGN + +N PPI AR++R++P +W+ RI L+ EL+GC
Sbjct: 367 KVFQGNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGC 412
Score = 96.3 bits (238), Expect = 6e-20
Identities = 59/171 (34%), Positives = 95/171 (55%), Gaps = 9/171 (5%)
Query: 158 CSGPLGIEGGIISNQQITASSTHRAL--FGLQ-KWYPYYARLNKKGLINAWTAAENDRWP 214
CS L E + QI ASS+ +++ G Q W P ARL +G A + N+ P
Sbjct: 255 CSRSLSFE----PDGQIRASSSWQSVNESGDQVHWSPGQARLQDQGPSWASGDSSNNHKP 310
Query: 215 --WIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFR 272
W++I+L K ++TG+ T G+ + Y+KS+ + + N+ W YK NE+ VF+
Sbjct: 311 REWLEIDLGEKKKITGIRTTGSTQSNFNFYVKSFVMNFKNNNSKWKTYKGIVNNEEKVFQ 370
Query: 273 GNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSGCSEPL 323
GN + P N+F PPI A+YVR+ PQ + L++EL+GC+++ ++ L
Sbjct: 371 GNSNFRDPVQNNFIPPIVARYVRVVPQTWHQRIALKVELIGCQITQGNDSL 421
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 102 bits (255), Expect = 6e-22
Identities = 49/134 (36%), Positives = 66/134 (49%), Gaps = 19/134 (14%)
Query: 26 CDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHN 85
C +PC NGG C +++CECP FT NC V+ CT NPC N
Sbjct: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVD------------RCTSNPCAN 413
Query: 86 GGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANYSCEC 145
GG C RG + +C+C GF G +C+ ++++C PC +GG C DL C C
Sbjct: 414 GGQC----LNRGPS---RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTC 466
Query: 146 PGEFMGRNCQYKCS 159
P F GR C+ + S
Sbjct: 467 PAGFSGRRCEVRTS 480
Score = 100 bits (250), Expect = 2e-21
Identities = 49/131 (37%), Positives = 64/131 (48%), Gaps = 22/131 (16%)
Query: 29 NPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPNPCHNGGT 88
+PC+NG C S++C C G+T +C C NPC NGG+
Sbjct: 292 SPCKNGATC-SNSGQRSYTCTCRPGYTGVDCE------------LELSECDSNPCRNGGS 338
Query: 89 CEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTD--LVANYSCECP 146
C+ E GY C CP G+ G+HC+H+ C PC NGG C + ANY+CECP
Sbjct: 339 CKDQED-------GYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECP 391
Query: 147 GEFMGRNCQYK 157
F G NC+ K
Sbjct: 392 PNFTGSNCEKK 402
Score = 83.2 bits (204), Expect = 5e-16
Identities = 52/144 (36%), Positives = 63/144 (43%), Gaps = 25/144 (17%)
Query: 22 KGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
K D C NPC NGG CL S C C GFT C V C N
Sbjct: 402 KVDRCTSNPCANGGQCLN--RGPSRMCRCRPGFTGTYCELHV------------SDCARN 447
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQ--HNINECEVEPCKNGGIC-TDLV 138
PC +GGTC D G +C CP GF+G C+ +I+ C PC N C TDL
Sbjct: 448 PCAHGGTCH-------DLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLS 500
Query: 139 AN-YSCECPGEFMGRNCQYKCSGP 161
+ + C CP F+G C++ P
Sbjct: 501 TDTFVCNCPYGFVGSRCEFPVGLP 524
Score = 75.1 bits (183), Expect = 1e-13
Identities = 38/135 (28%), Positives = 58/135 (42%), Gaps = 19/135 (14%)
Query: 22 KGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCSSVVEVASDEEEPTSAGPCTPN 81
+G +C+ NG C G + C C +G+ C + + +
Sbjct: 246 QGRLCNECIPHNG--CRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHH-----------S 292
Query: 82 PCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNINECEVEPCKNGGICTDLVANY 141
PC NG TC S Y C C G+ G+ C+ ++EC+ PC+NGG C D Y
Sbjct: 293 PCKNGATCSNSGQR------SYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGY 346
Query: 142 SCECPGEFMGRNCQY 156
C CP + G +C++
Sbjct: 347 HCLCPPGYYGLHCEH 361
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 102 bits (254), Expect = 8e-22
Identities = 59/170 (34%), Positives = 92/170 (54%), Gaps = 19/170 (11%)
Query: 157 KCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKG-------LINAWTAAE 209
KC P+G+E I + QI ASS R G Q+ RLN + AW A +
Sbjct: 384 KCP-PIGMESHRIEDNQIRASSMLRHGLGAQR-----GRLNMQTGATEDDYYDGAWCAED 437
Query: 210 NDRWPWIQINLQRKMRVTGVITQGAKRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTN--E 267
+ R WI+++ +R R TGVITQG +++ ++ + +SND +TW MY TN E
Sbjct: 438 DARTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMY----TNGYE 493
Query: 268 DMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELS 317
+M F GN+D +TP + P+ A+++R+YP +R+E+LGC ++
Sbjct: 494 EMTFHGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCSVA 543
Score = 98.6 bits (244), Expect = 1e-20
Identities = 54/157 (34%), Positives = 85/157 (54%), Gaps = 3/157 (1%)
Query: 322 PLGMKSGHIQDYQITASSIFRT-LNMDMFTWEPRKARLDKQGKVNAWTSGHNDQSQWLQV 380
P+GM+S I+D QI ASS+ R L + + AW + + ++QW++V
Sbjct: 387 PIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQTGATEDDYYDGAWCAEDDARTQWIEV 446
Query: 381 DLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDND 440
D T+ TG+ITQG H FV ++ + +SND + W +Y + + + F GN D D
Sbjct: 447 DTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYE--EMTFHGNVDKD 504
Query: 441 THRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCT 477
T + + P+ AR IRI P +W G + +R E+LGC+
Sbjct: 505 TPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCS 541
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.452
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,221,434
Number of Sequences: 37866
Number of extensions: 1069850
Number of successful extensions: 5766
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 185
Number of HSP's that attempted gapping in prelim test: 2310
Number of HSP's gapped (non-prelim): 1622
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.