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Search of human proteins with 29725622
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29725622 two pore segment channel 1 isoform 2 [Homo sapiens]
(816 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219689113 two pore segment channel 1 isoform 1 [Homo sapiens] 1624 0.0
gi|29725622 two pore segment channel 1 isoform 2 [Homo sapiens] 1624 0.0
gi|157502181 two pore segment channel 2 [Homo sapiens] 187 4e-47
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 115 2e-25
gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo s... 109 1e-23
gi|20070163 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505292 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505288 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505284 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505282 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505280 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505278 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505276 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505274 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505272 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505270 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|38505268 voltage-dependent calcium channel alpha 1G subunit i... 108 2e-23
gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo s... 107 6e-23
gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B ... 104 3e-22
gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E... 103 6e-22
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 102 1e-21
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 102 1e-21
gi|110349767 calcium channel, voltage-dependent, L type, alpha 1... 100 9e-21
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 98 3e-20
gi|38505290 voltage-dependent calcium channel alpha 1G subunit i... 96 1e-19
gi|38505286 voltage-dependent calcium channel alpha 1G subunit i... 96 1e-19
gi|193788732 calcium channel, voltage-dependent, L type, alpha 1... 80 6e-15
gi|193788730 calcium channel, voltage-dependent, L type, alpha 1... 80 6e-15
gi|193788728 calcium channel, voltage-dependent, L type, alpha 1... 80 6e-15
gi|193788724 calcium channel, voltage-dependent, L type, alpha 1... 80 6e-15
>gi|219689113 two pore segment channel 1 isoform 1 [Homo sapiens]
Length = 888
Score = 1624 bits (4205), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP 60
MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
Sbjct: 73 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP 132
Query: 61 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL 120
SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
Sbjct: 133 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL 192
Query: 121 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL 180
LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
Sbjct: 193 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL 252
Query: 181 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL 240
VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
Sbjct: 253 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL 312
Query: 241 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF 300
FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
Sbjct: 313 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF 372
Query: 301 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY 360
IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
Sbjct: 373 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY 432
Query: 361 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF 420
RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
Sbjct: 433 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF 492
Query: 421 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL 480
DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
Sbjct: 493 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL 552
Query: 481 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP 540
VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
Sbjct: 553 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP 612
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT 600
LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
Sbjct: 613 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT 672
Query: 601 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT 660
STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
Sbjct: 673 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT 732
Query: 661 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL 720
SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
Sbjct: 733 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL 792
Query: 721 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW 780
VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
Sbjct: 793 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW 852
Query: 781 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 816
YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
Sbjct: 853 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 888
>gi|29725622 two pore segment channel 1 isoform 2 [Homo sapiens]
Length = 816
Score = 1624 bits (4205), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP 60
MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP
Sbjct: 1 MAVSLDDDVPLILTLDEGGSAPLAPSNGLGQEELPSKNGGSYAIHDSQAPSLSSGGESSP 60
Query: 61 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL 120
SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL
Sbjct: 61 SSPAHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLL 120
Query: 121 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL 180
LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL
Sbjct: 121 LLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVL 180
Query: 181 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL 240
VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL
Sbjct: 181 VVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLL 240
Query: 241 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF 300
FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF
Sbjct: 241 FFMIIFAILGFYLFSPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYSRNPWSCVFF 300
Query: 301 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY 360
IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY
Sbjct: 301 IVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISY 360
Query: 361 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF 420
RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF
Sbjct: 361 RQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWF 420
Query: 421 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL 480
DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL
Sbjct: 421 DELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYL 480
Query: 481 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP 540
VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP
Sbjct: 481 VFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRP 540
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT 600
LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT
Sbjct: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNT 600
Query: 601 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT 660
STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT
Sbjct: 601 STVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT 660
Query: 661 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL 720
SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL
Sbjct: 661 SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKEEL 720
Query: 721 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW 780
VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW
Sbjct: 721 VAVLELYREARGASSDVTRLLETLSQMERYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEW 780
Query: 781 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 816
YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT
Sbjct: 781 YEEHAREQEQQRQLSSSAAPAAQQPPGSRQRSQTVT 816
>gi|157502181 two pore segment channel 2 [Homo sapiens]
Length = 752
Score = 187 bits (474), Expect = 4e-47
Identities = 173/684 (25%), Positives = 306/684 (44%), Gaps = 76/684 (11%)
Query: 64 AHNWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLS 123
A W++ +A +++++ + H DA ++ Y ++++ T L+L L+
Sbjct: 39 AARWDLCIDQAVVFIEDAIQY-RSINHRVDASSMWLYRRYYSNVCQRTLSFTIFLILFLA 97
Query: 124 LCEAPAVPALRLGIYVHA-----------TLELFALMVVVFELCMKLRWLGLHTFIRHKR 172
E P+ + A ++E+ L+V +L +K G F ++
Sbjct: 98 FIETPSSLTSTADVRYRAAPWEPPCGLTESVEVLCLLVFAADLSVKGYLFGWAHFQKNLW 157
Query: 173 TMVKTSVLVVQFVEAIVVLVRQMSH-VRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPP 231
+ VLVV V+ V L +R+ R LR FL+ + +++ L+ I SLP
Sbjct: 158 LLGYLVVLVVSLVDWTVSLSLVCHEPLRIRRLLRPFFLL--QNSSMMKKTLKCIRWSLPE 215
Query: 232 FMDILLLLLFFMIIFAILGFYLFSPNPSDP--------YFSTLENSIVSLFVLLTTANFP 283
+ LLL + +F + G LF+ D YF L S+ SL VLLTTAN P
Sbjct: 216 MASVGLLLAIHLCLFTMFGMLLFAGGKQDDGQDRERLTYFQNLPESLTSLLVLLTTANNP 275
Query: 284 DVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQ 343
DVM+P+YS+N +FFIV+ I F+MNLL A+++ F + ++ L +R +
Sbjct: 276 DVMIPAYSKNRAYAIFFIVFTVIGSLFLMNLLTAIIYSQFRGYLMKSLQTSLFRRRLGTR 335
Query: 344 HAYRLLISQ-----RRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKD 398
A+ +L S P + + L K ++ + + + + + LLS ++
Sbjct: 336 AAFEVLSSMVGEGGAFPQAVGVKPQNLLQVLQKVQLDSSHKQAMMEKVRSYGSVLLSAEE 395
Query: 399 FYDIY-EVAALKWKAKKNREHWFDELPRTALLIFKGI------NILVKSKAFQYFMYLVV 451
F ++ E+ K R + ++A +F N++ + ++LV+
Sbjct: 396 FQKLFNELDRSVVKEHPPRPEYQSPFLQSAQFLFGHYYFDYLGNLIALANLVSICVFLVL 455
Query: 452 AVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFD 511
+ + + F+L N VF+ Y +E+ LKV LG YLS N+FD
Sbjct: 456 DADVLPAERDDFILGILN----------CVFIVYYLLEMLLKVFALGLRGYLSYPSNVFD 505
Query: 512 FSVTVF---------------------AFLGLLALALNMEPFYFIVVLRPLQLLRLFKLK 550
+TV +GLL+L ++V R L+++ KL
Sbjct: 506 GLLTVVLLVLEISTLAVYRLPHPGWRPEMVGLLSLWDMTRMLNMLIVFRFLRIIPSMKL- 564
Query: 551 ERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWR 610
V T+ L+ M + G L++ YY FAI+G+ F G++ N+S A
Sbjct: 565 --MAVVASTVLGLVQNMRAFGGILVVVYYVFAIIGINLFRGVIVALPGNSSL---APANG 619
Query: 611 NHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMT 670
+ G+ E+ Y+ NNFD+ + VTL+ L VVNNW + ++ + WS++YF+
Sbjct: 620 SAPCGS---FEQLEYWANNFDDFAAALVTLWNLMVVNNWQVFLDAYRRYSGPWSKIYFVL 676
Query: 671 FYIVTMVV-MTIIVAFILEAFVFR 693
+++V+ V+ + + +A ILE F+ +
Sbjct: 677 WWLVSSVIWVNLFLALILENFLHK 700
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 115 bits (288), Expect = 2e-25
Identities = 158/743 (21%), Positives = 281/743 (37%), Gaps = 169/743 (22%)
Query: 45 HDSQAPSLSSGGESSPSSPAHN--------WEMNYQEAAIYLQEGENNDKFFTHPKDAKA 96
H A L E S H W + + A+YL +N + K
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ----KV 1290
Query: 97 LAAYLFAHNHLFYLMELATALLLLLLSLCEAPAV-PALRLGIYVHATLELFALMVVVFEL 155
+ +F H L ++ + L E P + P +++ + +F + V E+
Sbjct: 1291 ITHKMFDHVVLVFIFLNCVTIAL------ERPDIDPGSTERVFLSVSNYIFTAIFVA-EM 1343
Query: 156 CMKLRWLGL----HTFIRHKRTMVKTSVLVVQFVEAIVVLV-----RQMSHVRVTRALRC 206
+K+ LGL H +++ ++ +++V V+ +V + + + +RV R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 207 IF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFS------PNPS 259
+ L G++ + + SL P +I+L+ F IIF ILG LF P
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
Query: 260 DPYFST--------------------LENSIVSLFVLLTTANFPDVM-----------MP 288
ST L +++SLFVL + + ++M P
Sbjct: 1464 TRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
Query: 289 SYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRL 348
+ NPW ++FI +L I +F++N+ + VV + F HK Q A
Sbjct: 1524 VQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENF-------------HKCRQHQEAEEA 1570
Query: 349 LISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAAL 408
RR R+ E R R TF + P
Sbjct: 1571 ----RRREEKRLRRLE------------RRRRSTFPSPEAQRRP---------------- 1598
Query: 409 KWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGG 468
++ D P + I+ L S F+ ++ VN + + +E +
Sbjct: 1599 ---------YYADYSPTR-----RSIHSLCTSHYLDLFITFIICVNVITMSMEHY--NQP 1642
Query: 469 NFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLL----- 523
+ + + VF ++ E LK+ G + WN D ++ + + +G+
Sbjct: 1643 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1702
Query: 524 ---ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYS 580
AL +N + VLR ++L+L K+ R +LDT+ + LP++ +LGL ++ ++
Sbjct: 1703 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1762
Query: 581 FAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTL 640
+A +G+E F + C + EG F N +F+TL
Sbjct: 1763 YAALGVELFGRL---ECSEDNPC------------------EGLSRHATFSNFGMAFLTL 1801
Query: 641 FELTVVNNWYIIMEGVTSQTSH-----------WSRLYFMTFYIVTMVVMTIIVAFILEA 689
F ++ +NW IM+ + S S +YF+TF +V V+ +V +L
Sbjct: 1802 FRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMK 1861
Query: 690 FVFRMNYSRKNQDSEVDGGITLE 712
+ N +D+E+D I LE
Sbjct: 1862 HLEESN-KEAREDAELDAEIELE 1883
Score = 83.6 bits (205), Expect = 7e-16
Identities = 70/274 (25%), Positives = 130/274 (47%), Gaps = 36/274 (13%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V SK F + + + VN + + VE + + + S +VF +++ +E+ LK+
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYH--EQPEELTNALEISNIVFTSMFALEMLLKLLA 846
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKE---RY 553
GP+ Y+ + +N+FD + V + ++ A + VLR +LLR+ KL
Sbjct: 847 CGPLGYIRNPYNIFDGIIVVISVWEIVGQADGG-----LSVLRTFRLLRVLKLVRFLPAL 901
Query: 554 RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHT 613
R L + + + +A+ L++F + F+I+GM F C S D T
Sbjct: 902 RRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDT----GDT 950
Query: 614 VGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYF---MT 670
V +R NFD++L + VT+F++ +W +++ + TS W+ LYF MT
Sbjct: 951 VPDR----------KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMT 1000
Query: 671 FYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
F V+ ++VA ++E F + +R + D +
Sbjct: 1001 F--GNYVLFNLLVAILVEGFQAEGDANRSDTDED 1032
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/182 (25%), Positives = 89/182 (48%), Gaps = 14/182 (7%)
Query: 154 ELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCR 213
E+ +KL G +IR+ + ++V+ E + +S +R R LR + LV R
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLV--R 896
Query: 214 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN-----------PSDPY 262
+ +RR L + +++ LL+ F+ IF+ILG +LF P
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKN 956
Query: 263 FSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMNLLLAVVFD 321
F +L +IV++F +LT ++ V+ S + W+ ++F+ ++ Y + NLL+A++ +
Sbjct: 957 FDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
Query: 322 TF 323
F
Sbjct: 1017 GF 1018
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFL--GLLALALNMEPFYFIVVLRP 540
+ VE+ +K+ LG YL WN DF + V + L +++ + VLRP
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 207 ---LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/183 (23%), Positives = 73/183 (39%), Gaps = 37/183 (20%)
Query: 629 NFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILE 688
NFDNI +++ +F++ + W IM V S ++ +YF+ IV M I + ++
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFM-INLCLVVI 418
Query: 689 AFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQME 748
A F R++Q L + AR S+D T L + S+
Sbjct: 419 ATQFSETKQRESQ----------------------LMREQRARHLSNDST--LASFSEPG 454
Query: 749 RYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGS 808
+ + ++G R SL++Y W ++++ SA Q PG
Sbjct: 455 SCYEELLKYVGHIFRKVKRRSLRLYARWQSRW----------RKKVDPSAVQG--QGPGH 502
Query: 809 RQR 811
RQR
Sbjct: 503 RQR 505
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/71 (22%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 418
Query: 320 FDTFNDIEKRK 330
F++ ++R+
Sbjct: 419 ATQFSETKQRE 429
>gi|187828880 calcium channel, alpha 1A subunit isoform 3 [Homo
sapiens]
Length = 2261
Score = 109 bits (272), Expect = 1e-23
Identities = 140/654 (21%), Positives = 274/654 (41%), Gaps = 124/654 (18%)
Query: 144 ELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLV---------RQ 194
E + + + FE +K+ LG F HK + ++ V+ FV + ++ R
Sbjct: 137 EPYFIGIFCFEAGIKIIALG---FAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 193
Query: 195 MSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF 254
+ VRV R L+ + + ++ L+ I +++ P + I LLL F ++IFAI+G +
Sbjct: 194 LRAVRVLRPLKLVSGIP-----SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 255 -------------------SPNPS---------------DPYFSTLENSI---------- 270
SP P PY+ N I
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 271 VSLFVLLTTANFPDVMMPSY--SRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTF----N 324
+++F +T + D++ S S N W+ ++FI + I +F++NL+L V+ F
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 368
Query: 325 DIEKRKFKSLLLHKRTAIQH-----------AYRLLISQRRPAGISYRQFEGLMRFYKPR 373
+E R+ L L ++ I+ A +++++ G F+G +R +
Sbjct: 369 RVENRR-AFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK 427
Query: 374 MSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKG 433
S + +A +Q L + + A++K AK +F + R
Sbjct: 428 KSKTDLLNPEEAEDQ----LADIASVGSPFARASIK-SAKLENSTFFHKKERRMRFY--- 479
Query: 434 INILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLK 493
I +VK++AF + + +VA+N + + + + + S + ++ +FL ++ E+F+K
Sbjct: 480 IRRMVKTQAFYWTVLSLVALNTLCVAIVHY--NQPEWLSDFLYYAEFIFLGLFMSEMFIK 537
Query: 494 VAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERY 553
+ GLG Y S +N FD V + + ++ + + I VLR L+LLR+FK+ + +
Sbjct: 538 MYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYW 597
Query: 554 ---RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWR 610
RN++ ++ + + SL L +F FA++GM+ F
Sbjct: 598 ASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF--------------------- 636
Query: 611 NHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM-EGVTSQTSHWSRLYFM 669
G + +EG NFD + +T+F++ +W +M +G+ SQ + F
Sbjct: 637 ----GGQFNFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFS 691
Query: 670 TFYIV-----TMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKE 718
++IV ++ + +A ++ ++ Q+ E L + +KE
Sbjct: 692 IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKE 745
Score = 70.5 bits (171), Expect = 6e-12
Identities = 65/271 (23%), Positives = 114/271 (42%), Gaps = 37/271 (13%)
Query: 443 FQYFMYLVVAVNGVWILVETFMLKGGNF-FSKHVPWSYLVFLTIYGVELFLKVAGLGPV- 500
F+Y + + N + + +E + S+ + + F+ I+ E +K+ LG
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 501 ---EYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLR-LFKLKERYRNV 556
YL +GWN+ DF V + L + ++ + VLRPL+L+ + L+ +++
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSI 219
Query: 557 LDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC---------------CNTS 601
+ M LL +GL L FAI+G+EF+ G C C T
Sbjct: 220 MKAMIPLL----QIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTE 275
Query: 602 TVADAYRWRNHTVGNRTVVEEGYYYLNN----FDNILNSFVTLFELTVVNNWYIIMEGVT 657
A T N T + + NN FDNIL + +T+F+ + W ++
Sbjct: 276 EPA-------RTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
Query: 658 SQTSH-WSRLYFMTFYIVTMVVMTIIVAFIL 687
+ + W+ LYF+ I+ M +V +L
Sbjct: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVL 359
Score = 63.9 bits (154), Expect = 6e-10
Identities = 53/272 (19%), Positives = 120/272 (44%), Gaps = 35/272 (12%)
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
V S F+Y + ++A+N + ++++ + + + +VF +++ +E LKV
Sbjct: 1563 VVSPPFEYTIMAMIALNTIVLMMKFYGASVA--YENALRVFNIVFTSLFSLECVLKVMAF 1620
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALAL--NMEPFYFIVVLRPLQLLRLFKLKERYRN 555
G + Y WN+FDF + + +L N F+ + R +L++L + R
Sbjct: 1621 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1680
Query: 556 VLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVG 615
+L T + + + L + + ++ +AI+GM+ F G + + + + D ++ H
Sbjct: 1681 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDSDEDEFQITEH--- 1736
Query: 616 NRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM------------EGVTSQT--S 661
NNF + + LF W+ IM G+ ++ +
Sbjct: 1737 ------------NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGN 1784
Query: 662 HWSRLYFMTF-YIVTMVVMTIIVAFILEAFVF 692
++ YF++F ++ + +++ + VA I++ F +
Sbjct: 1785 EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1816
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/234 (24%), Positives = 104/234 (44%), Gaps = 26/234 (11%)
Query: 481 VFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDFSVT-----VFAFLGLLALALNMEP 531
VF ++ E+ +K+ LG V Y WN+ DF V FAF G + ++
Sbjct: 1283 VFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGN-SKGKDINT 1341
Query: 532 FYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCG 591
+ VLR L+ L+ K + + V D + L + ++ + ++F + FA+V ++ F G
Sbjct: 1342 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1401
Query: 592 IVFPNCCNTSTVADAYRWRNHTVGNRTVVE----EGYYYLNNFDNILNSFVTLFELTVVN 647
F +C + S + + + + V+ E Y ++DN+L + +TLF ++
Sbjct: 1402 KFF-HCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGE 1460
Query: 648 NWYIIMEGVTSQT------SHWSRLYFMTFYIVTMVV-----MTIIVAFILEAF 690
W +++ T S R+ FY+V VV + I VA I+ F
Sbjct: 1461 GWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1514
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/180 (23%), Positives = 79/180 (43%), Gaps = 41/180 (22%)
Query: 177 TSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLP--PFMD 234
T +LV +F + +S +R+ RA R I L+ Y +R L QS P++
Sbjct: 1643 TDILVTEFGNNFI----NLSFLRLFRAARLIKLLRQGYT--IRILLWTFVQSFKALPYVC 1696
Query: 235 ILLLLLFFMIIFAILGFYLFS---------PNPSDPY-------FSTLENSIVSLFVLLT 278
+L+ +LFF I+AI+G +F + D + F T +++ LF T
Sbjct: 1697 LLIAMLFF--IYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1754
Query: 279 TANFPDVMMPSYSRNP---------------WSCVFFIVYLSIELYFIMNLLLAVVFDTF 323
+ ++M+ S P ++ +F+ ++ + + ++NL +AV+ D F
Sbjct: 1755 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1814
>gi|20070163 voltage-dependent calcium channel alpha 1G subunit
isoform 1 [Homo sapiens]
Length = 2377
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1546 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1569
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1570 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1618
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1619 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1676
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1677 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1736
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1737 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1776
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1777 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1835
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1836 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1874
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505292 voltage-dependent calcium channel alpha 1G subunit
isoform 3 [Homo sapiens]
Length = 2343
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1548
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1549 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1584
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1585 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1702
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1703 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1742
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1743 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1801
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1802 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1840
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505288 voltage-dependent calcium channel alpha 1G subunit
isoform 12 [Homo sapiens]
Length = 2250
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1548
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1549 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1584
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1585 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1702
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1703 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1742
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1743 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1801
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1802 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1840
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505284 voltage-dependent calcium channel alpha 1G subunit
isoform 4 [Homo sapiens]
Length = 2332
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1546 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1569
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1570 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1618
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1619 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1676
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1677 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1736
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1737 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1776
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1777 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1835
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1836 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1874
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505282 voltage-dependent calcium channel alpha 1G subunit
isoform 8 [Homo sapiens]
Length = 2284
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1546 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1569
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1570 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1618
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1619 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1676
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1677 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1736
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1737 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1776
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1777 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1835
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1836 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1874
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505280 voltage-dependent calcium channel alpha 1G subunit
isoform 6 [Homo sapiens]
Length = 2306
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1546
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1547 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1595
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1596 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1653
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1654 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1713
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1714 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1753
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1754 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1812
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1813 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1851
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505278 voltage-dependent calcium channel alpha 1G subunit
isoform 11 [Homo sapiens]
Length = 2261
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1546
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1547 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1595
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1596 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1653
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1654 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1713
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1714 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1753
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1754 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1812
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1813 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1851
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505276 voltage-dependent calcium channel alpha 1G subunit
isoform 5 [Homo sapiens]
Length = 2321
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1546 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1571
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1572 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1607
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1608 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1665
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1666 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1725
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1726 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1765
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1766 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1824
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1825 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1863
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505274 voltage-dependent calcium channel alpha 1G subunit
isoform 7 [Homo sapiens]
Length = 2298
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1548
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1549 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1584
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1585 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1702
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1703 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1742
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1743 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1801
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1802 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1840
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505272 voltage-dependent calcium channel alpha 1G subunit
isoform 9 [Homo sapiens]
Length = 2273
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1545
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1546 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1571
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1572 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1607
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1608 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1665
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1666 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1725
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1726 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1765
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1766 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1824
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1825 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1863
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505270 voltage-dependent calcium channel alpha 1G subunit
isoform 2 [Homo sapiens]
Length = 2354
Score = 108 bits (270), Expect = 2e-23
Identities = 136/640 (21%), Positives = 255/640 (39%), Gaps = 135/640 (21%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R +
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRN------------- 1546
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
L L D I ++ ++ + ++ + R LL+ L S F+
Sbjct: 1547 -----LMLDDV--IASGSSASAASEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1595
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1596 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1653
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1654 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1713
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1714 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1753
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1754 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1812
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1813 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1851
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505268 voltage-dependent calcium channel alpha 1G subunit
isoform 14 [Homo sapiens]
Length = 2171
Score = 108 bits (270), Expect = 2e-23
Identities = 135/640 (21%), Positives = 250/640 (39%), Gaps = 146/640 (22%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F++N+ + VV + F+ +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQ 1522
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
+ + RR R+ + L R K R S
Sbjct: 1523 HQEEE-----------------EARR------REEKRLRRLEKKRRSKE----------- 1548
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K A+ + ++ + R LL+ L S F+
Sbjct: 1549 --------------------KQMAEAQCKPYYSDYSRFRLLVHH----LCTSHYLDLFIT 1584
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1585 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1642
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1643 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1702
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1703 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1742
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1743 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1801
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1802 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1840
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|187828892 calcium channel, alpha 1A subunit isoform 4 [Homo
sapiens]
Length = 2506
Score = 107 bits (266), Expect = 6e-23
Identities = 143/652 (21%), Positives = 272/652 (41%), Gaps = 121/652 (18%)
Query: 144 ELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLV---------RQ 194
E + + + FE +K+ LG F HK + ++ V+ FV + ++ R
Sbjct: 137 EPYFIGIFCFEAGIKIIALG---FAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRT 193
Query: 195 MSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF 254
+ VRV R L+ + + ++ L+ I +++ P + I LLL F ++IFAI+G +
Sbjct: 194 LRAVRVLRPLKLVSGIP-----SLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFY 248
Query: 255 -------------------SPNPS---------------DPYFSTLENSI---------- 270
SP P PY+ N I
Sbjct: 249 MGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAV 308
Query: 271 VSLFVLLTTANFPDVMMPSY--SRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTF----N 324
+++F +T + D++ S S N W+ ++FI + I +F++NL+L V+ F
Sbjct: 309 LTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERE 368
Query: 325 DIEKRKFKSLLLHKRTAIQ---HAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYL 381
+E R+ L L ++ I+ + Y IS+ ++ + +G R A R
Sbjct: 369 RVENRR-AFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDGEQRH---PFDALRRTT 424
Query: 382 TFKALNQNNTPLLSLKDFYDIYEV------AALKWKAKKNREHWFDELPRTALLIFKGIN 435
K+ P + DI V A++K AK +F + R I
Sbjct: 425 IKKSKTDLLNPEEAEDQLADIASVGSPFARASIK-SAKLENSTFFHKKERRMRFY---IR 480
Query: 436 ILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+VK++AF + + +VA+N + + + + + S + ++ +FL ++ E+F+K+
Sbjct: 481 RMVKTQAFYWTVLSLVALNTLCVAIVHY--NQPEWLSDFLYYAEFIFLGLFMSEMFIKMY 538
Query: 496 GLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERY-- 553
GLG Y S +N FD V + + ++ + + I VLR L+LLR+FK+ + +
Sbjct: 539 GLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWAS 598
Query: 554 -RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNH 612
RN++ ++ + + SL L +F FA++GM+ F
Sbjct: 599 LRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLF----------------------- 635
Query: 613 TVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM-EGVTSQTSHWSRLYFMTF 671
G + +EG NFD + +T+F++ +W +M +G+ SQ + F +
Sbjct: 636 --GGQFNFDEG-TPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIY 692
Query: 672 YIV-----TMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLEKEISKE 718
+IV ++ + +A ++ ++ Q+ E L + +KE
Sbjct: 693 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKE 744
Score = 70.5 bits (171), Expect = 6e-12
Identities = 65/271 (23%), Positives = 114/271 (42%), Gaps = 37/271 (13%)
Query: 443 FQYFMYLVVAVNGVWILVETFMLKGGNF-FSKHVPWSYLVFLTIYGVELFLKVAGLGPV- 500
F+Y + + N + + +E + S+ + + F+ I+ E +K+ LG
Sbjct: 100 FEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAF 159
Query: 501 ---EYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLR-LFKLKERYRNV 556
YL +GWN+ DF V + L + ++ + VLRPL+L+ + L+ +++
Sbjct: 160 HKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSI 219
Query: 557 LDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC---------------CNTS 601
+ M LL +GL L FAI+G+EF+ G C C T
Sbjct: 220 MKAMIPLL----QIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTE 275
Query: 602 TVADAYRWRNHTVGNRTVVEEGYYYLNN----FDNILNSFVTLFELTVVNNWYIIMEGVT 657
A T N T + + NN FDNIL + +T+F+ + W ++
Sbjct: 276 EPA-------RTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSN 328
Query: 658 SQTSH-WSRLYFMTFYIVTMVVMTIIVAFIL 687
+ + W+ LYF+ I+ M +V +L
Sbjct: 329 DASGNTWNWLYFIPLIIIGSFFMLNLVLGVL 359
Score = 63.9 bits (154), Expect = 6e-10
Identities = 53/272 (19%), Positives = 120/272 (44%), Gaps = 35/272 (12%)
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
V S F+Y + ++A+N + ++++ + + + +VF +++ +E LKV
Sbjct: 1562 VVSPPFEYTIMAMIALNTIVLMMKFYGASVA--YENALRVFNIVFTSLFSLECVLKVMAF 1619
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALAL--NMEPFYFIVVLRPLQLLRLFKLKERYRN 555
G + Y WN+FDF + + +L N F+ + R +L++L + R
Sbjct: 1620 GILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRI 1679
Query: 556 VLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVG 615
+L T + + + L + + ++ +AI+GM+ F G + + + + D ++ H
Sbjct: 1680 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF-GNIGIDVEDEDSDEDEFQITEH--- 1735
Query: 616 NRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM------------EGVTSQT--S 661
NNF + + LF W+ IM G+ ++ +
Sbjct: 1736 ------------NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRECGN 1783
Query: 662 HWSRLYFMTF-YIVTMVVMTIIVAFILEAFVF 692
++ YF++F ++ + +++ + VA I++ F +
Sbjct: 1784 EFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1815
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/234 (24%), Positives = 104/234 (44%), Gaps = 26/234 (11%)
Query: 481 VFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDFSVT-----VFAFLGLLALALNMEP 531
VF ++ E+ +K+ LG V Y WN+ DF V FAF G + ++
Sbjct: 1282 VFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGN-SKGKDINT 1340
Query: 532 FYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCG 591
+ VLR L+ L+ K + + V D + L + ++ + ++F + FA+V ++ F G
Sbjct: 1341 IKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKG 1400
Query: 592 IVFPNCCNTSTVADAYRWRNHTVGNRTVVE----EGYYYLNNFDNILNSFVTLFELTVVN 647
F +C + S + + + + V+ E Y ++DN+L + +TLF ++
Sbjct: 1401 KFF-HCTDESKEFEKDCRGKYLLYEKNEVKARDREWKKYEFHYDNVLWALLTLFTVSTGE 1459
Query: 648 NWYIIMEGVTSQT------SHWSRLYFMTFYIVTMVV-----MTIIVAFILEAF 690
W +++ T S R+ FY+V VV + I VA I+ F
Sbjct: 1460 GWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1513
Score = 37.7 bits (86), Expect = 0.043
Identities = 42/180 (23%), Positives = 79/180 (43%), Gaps = 41/180 (22%)
Query: 177 TSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLP--PFMD 234
T +LV +F + +S +R+ RA R I L+ Y +R L QS P++
Sbjct: 1642 TDILVTEFGNNFI----NLSFLRLFRAARLIKLLRQGYT--IRILLWTFVQSFKALPYVC 1695
Query: 235 ILLLLLFFMIIFAILGFYLFS---------PNPSDPY-------FSTLENSIVSLFVLLT 278
+L+ +LFF I+AI+G +F + D + F T +++ LF T
Sbjct: 1696 LLIAMLFF--IYAIIGMQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSAT 1753
Query: 279 TANFPDVMMPSYSRNP---------------WSCVFFIVYLSIELYFIMNLLLAVVFDTF 323
+ ++M+ S P ++ +F+ ++ + + ++NL +AV+ D F
Sbjct: 1754 GEAWHNIMLSCLSGKPCDKNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNF 1813
>gi|4502523 calcium channel, voltage-dependent, N type, alpha 1B
subunit [Homo sapiens]
Length = 2339
Score = 104 bits (260), Expect = 3e-22
Identities = 139/628 (22%), Positives = 263/628 (41%), Gaps = 105/628 (16%)
Query: 144 ELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLV---------RQ 194
E + + + FE +K+ LG F+ HK + ++ V+ FV + ++ R
Sbjct: 134 EPYFIGIFCFEAGIKIIALG---FVFHKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRT 190
Query: 195 MSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILG--FY 252
+ VRV R L+ + + ++ L+ I +++ P + I LLL F +++FAI+G FY
Sbjct: 191 LRAVRVLRPLKLVSGIP-----SLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFY 245
Query: 253 LFS------PNPSDPY-----------------------------------FSTLENSIV 271
+ PN +D F + +I+
Sbjct: 246 MGKFHKACFPNSTDAEPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNILFAIL 305
Query: 272 SLFVLLTTANFPDVMMPSYSR--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTF----ND 325
++F +T + D++ + N W+ ++FI + I +F++NL+L V+ F
Sbjct: 306 TVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERER 365
Query: 326 IEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKA 385
+E R+ L L ++ I+ + A E K + +R T K+
Sbjct: 366 VENRR-AFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDRNAEEKSPLDVLKRAATKKS 424
Query: 386 LNQNNTPLLSLKDFYDIYEVAALKWKA--KKNREHWFDELPRTALLIFKGINILVKSKAF 443
N F D+ V + +A K + R + I +VK+++F
Sbjct: 425 RNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSF 484
Query: 444 QYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYL 503
+ + VVA+N + + + + + + ++ VFL ++ E+ LK+ GLGP Y
Sbjct: 485 YWVVLCVVALNTLCVAMVHY--NQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYF 542
Query: 504 SSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERY---RNVLDTM 560
S +N FDF V V + ++ A+ + I VLR L+LLR+FK+ + + RN++ ++
Sbjct: 543 RSSFNCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSL 602
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ + SL L +F FA++GM+ F G + +++ T
Sbjct: 603 LNSMKSIISLLFLLFLFIVVFALLGMQLFGG--------------QFNFQDETP------ 642
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM-EGVTSQTSHWSRLYFMTFYIVTMVVM 679
NFD + +T+F++ +W +M G+ SQ S+ F +FY + + +
Sbjct: 643 ------TTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQ-GGVSKGMFSSFYFIVLTLF 695
Query: 680 ---TIIVAFILEAFVFRMNYSRKNQDSE 704
T++ F+ A N +D E
Sbjct: 696 GNYTLLNVFLAIAVDNLANAQELTKDEE 723
Score = 79.3 bits (194), Expect = 1e-14
Identities = 67/263 (25%), Positives = 114/263 (43%), Gaps = 22/263 (8%)
Query: 443 FQYFMYLVVAVNGVWILVETFMLKGGNF-FSKHVPWSYLVFLTIYGVELFLKVAGLGPV- 500
F+Y + + N + + +E + G S+ + + F+ I+ E +K+ LG V
Sbjct: 97 FEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVF 156
Query: 501 ---EYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLR-LFKLKERYRNV 556
YL +GWN+ DF V + L ++ + VLRPL+L+ + L+ +++
Sbjct: 157 HKGSYLRNGWNVMDFVVVLTGILATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSI 216
Query: 557 LDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCG----IVFPNCCNTSTVAD------- 605
+ M LL +GL L FAI+G+EF+ G FPN + V D
Sbjct: 217 MKAMVPLL----QIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCGKEA 272
Query: 606 AYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSH-WS 664
R R + + NFDNIL + +T+F+ + W I+ + W+
Sbjct: 273 PARLCEGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWN 332
Query: 665 RLYFMTFYIVTMVVMTIIVAFIL 687
LYF+ I+ M +V +L
Sbjct: 333 WLYFIPLIIIGSFFMLNLVLGVL 355
Score = 68.6 bits (166), Expect = 2e-11
Identities = 59/280 (21%), Positives = 117/280 (41%), Gaps = 59/280 (21%)
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSY--------LVFLTIYGVE 489
V S F+YF+ ++A+N V ++++ + P+ Y +VF +++ +E
Sbjct: 1468 VVSPPFEYFIMAMIALNTVVLMMKFY----------DAPYEYELMLKCLNIVFTSMFSME 1517
Query: 490 LFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALAL----NMEPFYFIVVLRPLQLLR 545
LK+ G + Y WN+FDF + + +L + N F+ + R +L++
Sbjct: 1518 CVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIK 1577
Query: 546 LFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVAD 605
L + R +L T + + + L + + ++ +AI+GM+ F I
Sbjct: 1578 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALD---------- 1627
Query: 606 AYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM------------ 653
+ T NR NNF L + + LF W+ IM
Sbjct: 1628 -----DDTSINRH---------NNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEQ 1673
Query: 654 EGVTSQTSHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVF 692
T S ++ YF++F ++ + +++ + VA I++ F +
Sbjct: 1674 ANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEY 1713
Score = 63.5 bits (153), Expect = 7e-10
Identities = 69/306 (22%), Positives = 139/306 (45%), Gaps = 30/306 (9%)
Query: 429 LIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGV 488
L+ + + +V + F+ + +V+A++ + + E ++ + + + + +F ++
Sbjct: 1138 LLRRFCHYIVTMRYFEVVILVVIALSSIALAAED-PVRTDSPRNNALKYLDYIFTGVFTF 1196
Query: 489 ELFLKVAGLG----PVEYLSSGWNLFDF-----SVTVFAFLGLLALALN-MEPFYFIVVL 538
E+ +K+ LG P Y WN+ DF ++ FAF G +N ++ + VL
Sbjct: 1197 EMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVL 1256
Query: 539 RPLQLL-RLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
RPL+ + RL KLK V D + L + ++ + ++F + FA++ ++ F G F C
Sbjct: 1257 RPLKTIKRLPKLKA----VFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF-YC 1311
Query: 598 CNTSTVADAYRWRNHTVGNRTVVE----EGYYYLNNFDNILNSFVTLFELTVVNNWYIIM 653
+ S + + + VE + Y ++DN+L + +TLF ++ W +++
Sbjct: 1312 TDESKELERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVL 1371
Query: 654 EGVTSQT------SHWSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDG 707
+ T S R+ FY+V VV F + FV + + + Q +V
Sbjct: 1372 KHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPF---FFVNIFVALIIITFQEQGDKVMS 1428
Query: 708 GITLEK 713
+LEK
Sbjct: 1429 ECSLEK 1434
Score = 39.7 bits (91), Expect = 0.011
Identities = 52/245 (21%), Positives = 103/245 (42%), Gaps = 38/245 (15%)
Query: 108 FYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTF 167
F + +A ++L++ +AP L L +F++ E +K+ G+ +
Sbjct: 1476 FIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSM-----ECVLKIIAFGVLNY 1530
Query: 168 IRHKRTMVKTSVLVVQFVEAIVVLVRQ------MSHVRVTRALRCIFLVDCRYCGGVRRN 221
R + ++ + +V + + +S +R+ RA R I L+ Y +R
Sbjct: 1531 FRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYT--IRIL 1588
Query: 222 LRQIFQSLP--PFMDILLLLLFFMIIFAILGFYLFSPNPSDP--------YFSTLENSIV 271
L QS P++ +L+ +LFF I+AI+G +F D F T +++
Sbjct: 1589 LWTFVQSFKALPYVCLLIAMLFF--IYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALM 1646
Query: 272 SLFVLLTTANFPDVMMPSYSR-------NPWSC------VFFIVYLSIELYFIMNLLLAV 318
LF T + ++M+ S N C +F+ ++ + + ++NL +AV
Sbjct: 1647 LLFRSATGEAWHEIMLSCLSNQACDEQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAV 1706
Query: 319 VFDTF 323
+ D F
Sbjct: 1707 IMDNF 1711
>gi|53832005 calcium channel, voltage-dependent, R type, alpha 1E
subunit [Homo sapiens]
Length = 2270
Score = 103 bits (257), Expect = 6e-22
Identities = 138/647 (21%), Positives = 270/647 (41%), Gaps = 140/647 (21%)
Query: 144 ELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIV-------------V 190
E + + + FE +K+ LG FI HK + ++ V+ F+ + V
Sbjct: 128 EPYFIGIFCFEAGIKIVALG---FIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHV 184
Query: 191 LVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILG 250
+R + VRV R L+ + + ++ L+ I +++ P + I LLL F +++FAI+G
Sbjct: 185 DLRTLRAVRVLRPLKLVSGIP-----SLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIG 239
Query: 251 FYLFS----------------------------------------PNPSDPYFSTLENSI 270
+S PN F + ++
Sbjct: 240 LEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPAGYECKDWIGPNDGITQFDNILFAV 299
Query: 271 VSLFVLLTTANFPDVMMPSYSRNP-----WSCVFFIVYLSIELYFIMNLLLAVVFDTF-- 323
+++F +T + V+ Y+ N W+ ++FI + I +F++NL+L V+ F
Sbjct: 300 LTVFQCITMEGWTTVL---YNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAK 356
Query: 324 --NDIEKRKFKSLLLHKRTAIQ---HAYR---------LLISQRRPAGISYRQFEGLMRF 369
+E R+ + L ++ I+ + YR +L + + AG S +
Sbjct: 357 ERERVENRR-AFMKLRRQQQIERELNGYRAWIDKAEEVMLAEENKNAGTSALEVLRRATI 415
Query: 370 YKPRMSARERYLTFKA---LNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRT 426
+ R A R + + ++ TPL A++K AK + +F R
Sbjct: 416 KRSRTEAMTRDSSDEHCVDISSVGTPLAR----------ASIK-SAKVDGVSYFRHKER- 463
Query: 427 ALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIY 486
L+ I +VKS+ F + + +VA+N + + + + + ++ +FL ++
Sbjct: 464 --LLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHH--NQPQWLTHLLYYAEFLFLGLF 519
Query: 487 GVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRL 546
+E+ LK+ G+GP Y S +N FDF VTV + ++ + I VLR L+LLR+
Sbjct: 520 LLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRI 579
Query: 547 FKLKERY---RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTV 603
FK+ + + RN++ ++ + + SL L +F FA++GM+ F G
Sbjct: 580 FKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGG------------ 627
Query: 604 ADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM-EGVTSQ--- 659
+ + + T NFD + +T+F++ +W +M G+ SQ
Sbjct: 628 --RFNFNDGTPS------------ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGV 673
Query: 660 -TSHWSRLYFMTFYIV-TMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
+ WS +YF+ + ++ + +A ++ ++ Q+ E
Sbjct: 674 SSGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE 720
Score = 67.8 bits (164), Expect = 4e-11
Identities = 79/333 (23%), Positives = 147/333 (44%), Gaps = 36/333 (10%)
Query: 391 TPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGIN-------ILVKSKAF 443
+PL + D EV K K K+ RE +P +++ IF N +V + F
Sbjct: 1097 SPLKEAEIREDEEEVEKKKQK-KEKRETGKAMVPHSSMFIFSTTNPIRRACHYIVNLRYF 1155
Query: 444 QYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPV--- 500
+ + LV+A + + + E +L +K + + VF ++ E+ +K+ G +
Sbjct: 1156 EMCILLVIAASSIALAAEDPVLTNSER-NKVLRYFDYVFTGVFTFEMVIKMIDQGLILQD 1214
Query: 501 -EYLSSGWNLFDFSVTVFAFLGL-LALAL------NMEPFYFIVVLRPLQLLRLFKLKER 552
Y WN+ DF V V A + LA AL +++ + VLR L+ L+ K +
Sbjct: 1215 GSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPK 1274
Query: 553 YRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNH 612
+ V D + L + ++ + +F + FA++ ++ F G F C ++S + N+
Sbjct: 1275 LKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFF-YCTDSSKDTEKECIGNY 1333
Query: 613 TVGNRTVVE----EGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQT------SH 662
+ +E E + ++DNI+ + +TLF ++ W +++ T S
Sbjct: 1334 VDHEKNKMEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSR 1393
Query: 663 WSRLYFMTFYIVTMVV-----MTIIVAFILEAF 690
+R+ FY+V VV + I VA I+ F
Sbjct: 1394 SNRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1426
Score = 67.4 bits (163), Expect = 5e-11
Identities = 64/276 (23%), Positives = 121/276 (43%), Gaps = 28/276 (10%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNF-FSKHVPWSYLVFLTIYGVELFLKVA 495
L+ F+Y + + N + + +E + + S+ + + F+ I+ E +K+
Sbjct: 85 LIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFIGIFCFEAGIKIV 144
Query: 496 GLGPV----EYLSSGWNLFDFSVTVFAFLGLLALALN----MEPFYFIVVLRPLQLLR-L 546
LG + YL +GWN+ DF V + L N + + VLRPL+L+ +
Sbjct: 145 ALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRPLKLVSGI 204
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC-CNTSTVAD 605
L+ ++++ M LL +GL L FAI+G+EF+ G + C N S + +
Sbjct: 205 PSLQIVLKSIMKAMVPLL----QIGLLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILE 260
Query: 606 AYRWRNHTVGNRTVVEEGYYY---------LNNFDNILNSFVTLFELTVVNNWYIIMEGV 656
+ H G + GY + FDNIL + +T+F+ + W ++
Sbjct: 261 GFD-PPHPCGVQG-CPAGYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNT 318
Query: 657 TSQT-SHWSRLYFMTFYIV-TMVVMTIIVAFILEAF 690
+ W+ LYF+ I+ + V+ +++ + F
Sbjct: 319 NDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEF 354
Score = 59.3 bits (142), Expect = 1e-08
Identities = 72/337 (21%), Positives = 137/337 (40%), Gaps = 67/337 (19%)
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
V S +F+Y + ++A+N V ++++ + + + + + F ++ +E LKV
Sbjct: 1475 VVSPSFEYTIMAMIALNTVVLMMKYY--SAPCTYELALKYLNIAFTMVFSLECVLKVIAF 1532
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALA----LNMEPF--YFIVVLRPLQLLRLFKLKE 551
G + Y WN+FDF +TV + + L +N F F+ + R +L++L +
Sbjct: 1533 GFLNYFRDTWNIFDF-ITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGY 1591
Query: 552 RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRN 611
R +L T + + + L + + ++ +AI+GM+ F
Sbjct: 1592 TIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVF---------------------- 1629
Query: 612 HTVGNRTVVEEGYYYL-NNFDNILNSFVTLFELTVVNNWYIIM------EGVTSQT---- 660
GN + EE + NNF + S + LF W IM +G T
Sbjct: 1630 ---GNIKLDEESHINRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPS 1686
Query: 661 ---------SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGIT 710
+ + +YF++F + + +++ + VA I++ N+ +DS + G
Sbjct: 1687 GQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMD------NFEYLTRDSSILGPHH 1740
Query: 711 LEKEISKEELVAVLELYREARGASSDVTRLLETLSQM 747
L +E V V Y A T + E L+ M
Sbjct: 1741 L------DEFVRVWAEYDRAACGRIHYTEMYEMLTLM 1771
Score = 37.4 bits (85), Expect = 0.057
Identities = 57/248 (22%), Positives = 99/248 (39%), Gaps = 46/248 (18%)
Query: 113 LATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLHTFIRHKR 172
+A ++L++ AP L L L + MV E +K+ G + R
Sbjct: 1488 IALNTVVLMMKYYSAPCTYELALKY-----LNIAFTMVFSLECVLKVIAFGFLNYFRDTW 1542
Query: 173 TMVKTSVLVVQFVEAIVV---LVR----QMSHVRVTRALRCIFLVDCRYCGGVRRNLRQI 225
+ ++ E I+ LV MS +++ RA R I L+ Y +R L
Sbjct: 1543 NIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYT--IRILLWTF 1600
Query: 226 FQSLP--PFMDILLLLLFFMIIFAILGFYLFSPNPSDPY--------FSTLENSIVSLFV 275
QS P++ +L+ +LFF I+AI+G +F D F + S++ LF
Sbjct: 1601 VQSFKALPYVCLLIAMLFF--IYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFR 1658
Query: 276 LLTTANFPDVMM--------------PSYSRNPWSC------VFFIVYLSIELYFIMNLL 315
T + ++M+ PS C V+F+ ++ + ++NL
Sbjct: 1659 SATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLF 1718
Query: 316 LAVVFDTF 323
+AV+ D F
Sbjct: 1719 VAVIMDNF 1726
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 102 bits (254), Expect = 1e-21
Identities = 152/715 (21%), Positives = 267/715 (37%), Gaps = 169/715 (23%)
Query: 66 NWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLC 125
+W ++ ++YL EN + L + AH LF + LA L +
Sbjct: 1105 DWCEVREDWSVYLFSPENR---------FRVLCQTIIAHK-LFDYVVLAFIFLNCITIAL 1154
Query: 126 EAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLH----TFIRHKRTMVKTSVLV 181
E P + A + V E+ +K+ LGL+ ++R ++ ++
Sbjct: 1155 ERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVF 1214
Query: 182 VQFVEAIVVLV-----RQMSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDI 235
V ++ +V L + + +RV R LR + L G++ + + SL P +I
Sbjct: 1215 VSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNI 1274
Query: 236 LLLLLFFMIIFAILGFYLFS--------------PNPSDPY------------FSTLENS 269
+L+ F IIF ILG LF N SD F L +
Sbjct: 1275 VLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQA 1334
Query: 270 IVSLFVLLTTANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLA- 317
++SLFVL + + ++M P + NPW LYFI LL+
Sbjct: 1335 LMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWML----------LYFISFLLIVS 1384
Query: 318 -VVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSA 376
V + F + F H+ + A R R+ + L R K R A
Sbjct: 1385 FFVLNMFVGVVVENFHKCRQHQEA--EEARR-------------REEKRLRRLEKKRRKA 1429
Query: 377 RERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINI 436
+ R ++ T LLI
Sbjct: 1430 Q--------------------------------------RLPYYATYCHTRLLIHS---- 1447
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+ S F+ ++ +N V + +E + + + +F T++ +E LK+
Sbjct: 1448 MCTSHYLDIFITFIICLNVVTMSLEHY--NQPTSLETALKYCNYMFTTVFVLEAVLKLVA 1505
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFK 548
G + WN D ++ + + +G+ AL +N + VLR ++L+L K
Sbjct: 1506 FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLK 1565
Query: 549 LKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYR 608
+ R +LDT+ + LP++ +LGL ++ ++ +A +G+E F +V CN
Sbjct: 1566 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV----CNDENPC---- 1617
Query: 609 WRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSR--- 665
EG F+N +F+TLF+++ +NW IM+ +H R
Sbjct: 1618 -------------EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCL 1664
Query: 666 --------LYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
LYF++F + V+ +V +L + N +D+E+D + LE
Sbjct: 1665 SSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSN-KEAQEDAEMDAELELE 1718
Score = 82.0 bits (201), Expect = 2e-15
Identities = 69/274 (25%), Positives = 129/274 (47%), Gaps = 36/274 (13%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V SK F + + + VN V + +E + + + +VF +++ +E+ LK+A
Sbjct: 601 IVDSKYFNRGIMMAILVNTVSMGIEHH--EQPEELTNILEICNVVFTSMFALEMILKLAA 658
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKE---RY 553
G +YL + +N+FD + + + ++ A + VLR +LLR+ KL
Sbjct: 659 FGLFDYLRNPYNIFDSIIVIISIWEIVGQADGG-----LSVLRTFRLLRVLKLVRFMPAL 713
Query: 554 RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHT 613
R L + + + +A+ + L++F + F+I+GM F C S D T
Sbjct: 714 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLRTDT----GDT 762
Query: 614 VGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYF---MT 670
V +R NFD++L + VT+F++ +W +++ + TS W+ LYF MT
Sbjct: 763 VPDR----------KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMT 812
Query: 671 FYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
F V+ ++VA ++E F + +R D +
Sbjct: 813 F--GNYVLFNLLVAILVEGFQAEGDANRSYSDED 844
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/182 (25%), Positives = 93/182 (51%), Gaps = 14/182 (7%)
Query: 154 ELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCR 213
E+ +KL GL ++R+ + + ++++ E + +S +R R LR + LV R
Sbjct: 651 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV--R 708
Query: 214 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN-----------PSDPY 262
+ +RR L + +++ +LL+ F+ IF+ILG ++F P
Sbjct: 709 FMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKN 768
Query: 263 FSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMNLLLAVVFD 321
F +L +IV++F +LT ++ V+ S +PW+ ++F+ ++ Y + NLL+A++ +
Sbjct: 769 FDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVE 828
Query: 322 TF 323
F
Sbjct: 829 GF 830
Score = 46.6 bits (109), Expect = 9e-05
Identities = 52/244 (21%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 150 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFV----EAIVV---------LVRQMS 196
V V E +KL GL F + + + +++++ + E I + ++R M
Sbjct: 1494 VFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMR 1553
Query: 197 HVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF-- 254
+R+ R L+ + + G+R L + Q+LP ++ LL + I+A LG LF
Sbjct: 1554 VLRIARVLKLL-----KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1608
Query: 255 ----SPNPSD--PYFSTLEN---SIVSLFVLLTTANFPDVM---MPSYSRNPWSC----- 297
NP + +T EN + ++LF + T N+ +M + + + SC
Sbjct: 1609 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ 1668
Query: 298 ----VFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQR 353
++F+ ++ + ++N+++AV+ +D K + + ++ A+ L R
Sbjct: 1669 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPR 1728
Query: 354 RPAG 357
P G
Sbjct: 1729 LPTG 1732
Score = 34.3 bits (77), Expect = 0.48
Identities = 52/279 (18%), Positives = 96/279 (34%), Gaps = 82/279 (29%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFL--GLLALALNMEPFYFIVVLRP 540
+ +E+ LK+ LG YL WN DF + + + L +N+ + VLRP
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYY--------------------- 579
L+ + R +++ + + LP + ++ L ++
Sbjct: 186 LKAINRVP---SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLE 242
Query: 580 -SFAIVG---------------MEFFCGIVFPN------------------CCNTSTVAD 605
+F I G M F C + N C + V D
Sbjct: 243 ENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYD 302
Query: 606 AYRWRNHTVGNRTVVEEGYYY-------------LNNFDNILNSFVTLFELTVVNNWYII 652
R + V YY NFDNI +++ +F++ + W I
Sbjct: 303 FGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEI 362
Query: 653 MEGVTSQTSHWSRLYFM------TFYIVTMVVMTIIVAF 685
M V S ++ +YF+ +F+++ + ++ I F
Sbjct: 363 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/84 (20%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Query: 255 SPNPSDPYFSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFI 311
+P+ F + + + +F ++T + ++M M ++S ++ ++FI+ + + +F+
Sbjct: 332 NPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSF--YNFIYFILLIIVGSFFM 389
Query: 312 MNLLLAVVFDTFNDIEKRKFKSLL 335
+NL L V+ F++ ++R+ + +L
Sbjct: 390 INLCLVVIATQFSETKQREHRLML 413
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 102 bits (254), Expect = 1e-21
Identities = 152/715 (21%), Positives = 267/715 (37%), Gaps = 169/715 (23%)
Query: 66 NWEMNYQEAAIYLQEGENNDKFFTHPKDAKALAAYLFAHNHLFYLMELATALLLLLLSLC 125
+W ++ ++YL EN + L + AH LF + LA L +
Sbjct: 1140 DWCEVREDWSVYLFSPENR---------FRVLCQTIIAHK-LFDYVVLAFIFLNCITIAL 1189
Query: 126 EAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGLH----TFIRHKRTMVKTSVLV 181
E P + A + V E+ +K+ LGL+ ++R ++ ++
Sbjct: 1190 ERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVF 1249
Query: 182 VQFVEAIVVLV-----RQMSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDI 235
V ++ +V L + + +RV R LR + L G++ + + SL P +I
Sbjct: 1250 VSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNI 1309
Query: 236 LLLLLFFMIIFAILGFYLFS--------------PNPSDPY------------FSTLENS 269
+L+ F IIF ILG LF N SD F L +
Sbjct: 1310 VLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYRWVHHKYNFDNLGQA 1369
Query: 270 IVSLFVLLTTANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLA- 317
++SLFVL + + ++M P + NPW LYFI LL+
Sbjct: 1370 LMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWML----------LYFISFLLIVS 1419
Query: 318 -VVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSA 376
V + F + F H+ + A R R+ + L R K R A
Sbjct: 1420 FFVLNMFVGVVVENFHKCRQHQEA--EEARR-------------REEKRLRRLEKKRRKA 1464
Query: 377 RERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINI 436
+ R ++ T LLI
Sbjct: 1465 Q--------------------------------------RLPYYATYCHTRLLIHS---- 1482
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+ S F+ ++ +N V + +E + + + +F T++ +E LK+
Sbjct: 1483 MCTSHYLDIFITFIICLNVVTMSLEHY--NQPTSLETALKYCNYMFTTVFVLEAVLKLVA 1540
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFK 548
G + WN D ++ + + +G+ AL +N + VLR ++L+L K
Sbjct: 1541 FGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLK 1600
Query: 549 LKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYR 608
+ R +LDT+ + LP++ +LGL ++ ++ +A +G+E F +V CN
Sbjct: 1601 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLV----CNDENPC---- 1652
Query: 609 WRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSR--- 665
EG F+N +F+TLF+++ +NW IM+ +H R
Sbjct: 1653 -------------EGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCL 1699
Query: 666 --------LYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
LYF++F + V+ +V +L + N +D+E+D + LE
Sbjct: 1700 SSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSN-KEAQEDAEMDAELELE 1753
Score = 82.0 bits (201), Expect = 2e-15
Identities = 69/274 (25%), Positives = 129/274 (47%), Gaps = 36/274 (13%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V SK F + + + VN V + +E + + + +VF +++ +E+ LK+A
Sbjct: 636 IVDSKYFNRGIMMAILVNTVSMGIEHH--EQPEELTNILEICNVVFTSMFALEMILKLAA 693
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKE---RY 553
G +YL + +N+FD + + + ++ A + VLR +LLR+ KL
Sbjct: 694 FGLFDYLRNPYNIFDSIIVIISIWEIVGQADGG-----LSVLRTFRLLRVLKLVRFMPAL 748
Query: 554 RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHT 613
R L + + + +A+ + L++F + F+I+GM F C S D T
Sbjct: 749 RRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFG-------CKFSLRTDT----GDT 797
Query: 614 VGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYF---MT 670
V +R NFD++L + VT+F++ +W +++ + TS W+ LYF MT
Sbjct: 798 VPDR----------KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMT 847
Query: 671 FYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
F V+ ++VA ++E F + +R D +
Sbjct: 848 F--GNYVLFNLLVAILVEGFQAEGDANRSYSDED 879
Score = 69.7 bits (169), Expect = 1e-11
Identities = 46/182 (25%), Positives = 93/182 (51%), Gaps = 14/182 (7%)
Query: 154 ELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCR 213
E+ +KL GL ++R+ + + ++++ E + +S +R R LR + LV R
Sbjct: 686 EMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLRVLKLV--R 743
Query: 214 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN-----------PSDPY 262
+ +RR L + +++ +LL+ F+ IF+ILG ++F P
Sbjct: 744 FMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKN 803
Query: 263 FSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMNLLLAVVFD 321
F +L +IV++F +LT ++ V+ S +PW+ ++F+ ++ Y + NLL+A++ +
Sbjct: 804 FDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPWASLYFVALMTFGNYVLFNLLVAILVE 863
Query: 322 TF 323
F
Sbjct: 864 GF 865
Score = 46.6 bits (109), Expect = 9e-05
Identities = 52/244 (21%), Positives = 106/244 (43%), Gaps = 41/244 (16%)
Query: 150 VVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFV----EAIVV---------LVRQMS 196
V V E +KL GL F + + + +++++ + E I + ++R M
Sbjct: 1529 VFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMR 1588
Query: 197 HVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF-- 254
+R+ R L+ + + G+R L + Q+LP ++ LL + I+A LG LF
Sbjct: 1589 VLRIARVLKLL-----KMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGK 1643
Query: 255 ----SPNPSD--PYFSTLEN---SIVSLFVLLTTANFPDVM---MPSYSRNPWSC----- 297
NP + +T EN + ++LF + T N+ +M + + + SC
Sbjct: 1644 LVCNDENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRDCTHDERSCLSSLQ 1703
Query: 298 ----VFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQR 353
++F+ ++ + ++N+++AV+ +D K + + ++ A+ L R
Sbjct: 1704 FVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPR 1763
Query: 354 RPAG 357
P G
Sbjct: 1764 LPTG 1767
Score = 34.3 bits (77), Expect = 0.48
Identities = 52/279 (18%), Positives = 96/279 (34%), Gaps = 82/279 (29%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFL--GLLALALNMEPFYFIVVLRP 540
+ +E+ LK+ LG YL WN DF + + + L +N+ + VLRP
Sbjct: 126 FAMEMVLKMVALGIFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRP 185
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYY--------------------- 579
L+ + R +++ + + LP + ++ L ++
Sbjct: 186 LKAINRVP---SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLE 242
Query: 580 -SFAIVG---------------MEFFCGIVFPN------------------CCNTSTVAD 605
+F I G M F C + N C + V D
Sbjct: 243 ENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDVYD 302
Query: 606 AYRWRNHTVGNRTVVEEGYYY-------------LNNFDNILNSFVTLFELTVVNNWYII 652
R + V YY NFDNI +++ +F++ + W I
Sbjct: 303 FGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAWIVIFQVITLEGWVEI 362
Query: 653 MEGVTSQTSHWSRLYFM------TFYIVTMVVMTIIVAF 685
M V S ++ +YF+ +F+++ + ++ I F
Sbjct: 363 MYYVMDAHSFYNFIYFILLIIVGSFFMINLCLVVIATQF 401
Score = 31.6 bits (70), Expect = 3.1
Identities = 17/84 (20%), Positives = 48/84 (57%), Gaps = 5/84 (5%)
Query: 255 SPNPSDPYFSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFI 311
+P+ F + + + +F ++T + ++M M ++S ++ ++FI+ + + +F+
Sbjct: 332 NPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVMDAHSF--YNFIYFILLIIVGSFFM 389
Query: 312 MNLLLAVVFDTFNDIEKRKFKSLL 335
+NL L V+ F++ ++R+ + +L
Sbjct: 390 INLCLVVIATQFSETKQREHRLML 413
>gi|110349767 calcium channel, voltage-dependent, L type, alpha 1S
subunit [Homo sapiens]
Length = 1873
Score = 99.8 bits (247), Expect = 9e-21
Identities = 165/722 (22%), Positives = 285/722 (39%), Gaps = 167/722 (23%)
Query: 115 TALLLLLLSLCEAPAV---------PALRLGIYVHATLELFALMVVVFELCMKLRWLGLH 165
T +LL + + C A AV +L LG+ LE F L+V E MK+ G
Sbjct: 55 TIILLTIFANCVALAVYLPMPEDDNNSLNLGL---EKLEYFFLIVFSIEAAMKIIAYG-- 109
Query: 166 TFIRHKRTMVKTSVLVVQF----VEAIVVLVRQM----SH------------VRVTRALR 205
F+ H+ +++ V+ F + V++ Q+ SH V+ RA R
Sbjct: 110 -FLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKALRAFR 168
Query: 206 CIFLVDCRYCGGV---RRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFS------- 255
L R GV + L IF+++ P I LL+LF +II+AI+G LF
Sbjct: 169 V--LRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHKTC 226
Query: 256 -----------------------------------------PNPSDPYFSTLENSIVSLF 274
PN +F S+++++
Sbjct: 227 YFIGTDIVATVENEEPSPCARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGFSMLTVY 286
Query: 275 VLLTTANFPDVM--MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFK 332
+T + DV+ + N W ++F+ + + +FI+NL+L V+ F E+ K K
Sbjct: 287 QCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK-EREKAK 345
Query: 333 SL----LLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
S L ++ + R +S I+ + + F + ++S E
Sbjct: 346 SRGTFQKLREKQQLDEDLRGYMSW-----ITQGEVMDVEDFREGKLSLDE---------- 390
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKG-INILVKSKAFQYFM 447
D +YE+A L K + HW R IF+ + +VKSK F + +
Sbjct: 391 ------GGSDTESLYEIAGLN-KIIQFIRHW-----RQWNRIFRWKCHDIVKSKVFYWLV 438
Query: 448 YLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGW 507
L+VA+N + I E + ++ + V L+++ E+ +K+ GLG +Y S +
Sbjct: 439 ILIVALNTLSIASEHH--NQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
Query: 508 NLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYR---NVLDTMFELL 564
N FD V L +L + I VLR ++LLR+FK+ + + N++ ++ +
Sbjct: 497 NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSI 556
Query: 565 PRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGY 624
+ASL L L +F FA++GM+ F G R E+
Sbjct: 557 RSIASLLLLLFLFIVIFALLGMQLF-------------------------GGRYDFEDTE 591
Query: 625 YYLNNFDNILNSFVTLFELTVVNNWY------IIMEGVTSQTSHWSRLYFMTF-----YI 673
+NFDN + +++F++ +W I+ G S +YF+ YI
Sbjct: 592 VRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYI 651
Query: 674 VTMVVMTIIVAFILEAFVFRMNYSRKNQDS---EVDGGITLEKEISKEELVAVLELYREA 730
+ V + I V + EA K ++ ++ G+ + E K + LE +
Sbjct: 652 LLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQKPKG 711
Query: 731 RG 732
G
Sbjct: 712 EG 713
Score = 87.0 bits (214), Expect = 6e-17
Identities = 125/608 (20%), Positives = 252/608 (41%), Gaps = 76/608 (12%)
Query: 148 LMVVVFELCMKLRWLGLHTFI-----RHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTR 202
L + E+ MK+ LGL + R +V + +L + VE+ + +S +R R
Sbjct: 472 LSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEILLVESGAMTPLGISVLRCIR 531
Query: 203 ALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFS------- 255
LR IF + +Y + + + S+ +LLLL F++IFA+LG LF
Sbjct: 532 LLR-IFKIT-KYWTSLSNLVASLLNSIRSIASLLLLLFLFIVIFALLGMQLFGGRYDFED 589
Query: 256 PNPSDPYFSTLENSIVSLFVLLTTANFPDVMM--------PSYSRNPWSCVFFIVYLSIE 307
F +++S+F +LT ++ +M PSY C++FI+
Sbjct: 590 TEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYP-GMLVCIYFIILFVCG 648
Query: 308 LYFIMNLLLAVVFDTFNDIE-------------KRKFKSLLLHKRTAIQHAYRLLISQRR 354
Y ++N+ LA+ D + E KR+ S L ++ + + +++
Sbjct: 649 NYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMAKKLEQK 708
Query: 355 PAG--------ISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVA 406
P G + +FE + K + + F ++ + P + L
Sbjct: 709 PKGEGIPTTAKLKIDEFESNVNEVKDPYPSAD----FPGDDEEDEPEIPLSPRPRPLAEL 764
Query: 407 ALKWKAKKNRE--HWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFM 464
LK KA E +F P + + + +V + F F+ L + ++ + E
Sbjct: 765 QLKEKAVPIPEASSFFIFSPTNKIRVL--CHRIVNATWFTNFILLFILLSSAALAAED-P 821
Query: 465 LKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGW-NLFDFSVTVFAFLGLL 523
++ + ++ + + F +++ VE+ LK+ G + S N F+ + + L+
Sbjct: 822 IRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLI 881
Query: 524 ALALNMEPFYFIVVLRPLQLLRLFKLKER---YRNVLDTMFELLPRMASLGLTLLIFYYS 580
++ L + +LR L++LR + R ++V+ MF + + ++ L + +
Sbjct: 882 SMGLESSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFM 941
Query: 581 FAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTV---GNRTVVE----EGYYYLNNFDNI 633
FA +G++ F G F C + S + + + V G+ +E E + +FDN+
Sbjct: 942 FACIGVQLFKGKFF-RCTDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNV 1000
Query: 634 LNSFVTLFELTVVNNW-YIIMEGVTSQTSHWSRLY--------FMTFYIVTMV--VMTII 682
L++ ++LF ++ W ++ + + S +Y F YI+ + +M I
Sbjct: 1001 LSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIF 1060
Query: 683 VAFILEAF 690
V F++ F
Sbjct: 1061 VGFVIVTF 1068
Score = 59.7 bits (143), Expect = 1e-08
Identities = 130/663 (19%), Positives = 244/663 (36%), Gaps = 173/663 (26%)
Query: 117 LLLLLLSLCEAPAVPALRLGIYVHATLELFAL---MVVVFELCMKLRWLG--LH--TFIR 169
LL +LLS A +R + L+ F + V E+ +K+ G LH +F R
Sbjct: 806 LLFILLSSAALAAEDPIRADSMRNQILKHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCR 865
Query: 170 HKRTMVKTSVLVVQFVE-----AIVVLVRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQ 224
+ M+ V+ V + + + +V+ + +RV R LR I G++ ++
Sbjct: 866 NYFNMLDLLVVAVSLISMGLESSAISVVKILRVLRVLRPLRAI-----NRAKGLKHVVQC 920
Query: 225 IFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN--------------------------- 257
+F ++ +I+L+ +FA +G LF
Sbjct: 921 MFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRCTDLSKMTEEECRGYYYVYKDGDP 980
Query: 258 -----------PSDPYFSTLENSIVSLFVLLTTANFPDVMM-----------PSYSRNPW 295
SD +F + ++++SLF + T +P ++ P Y+
Sbjct: 981 MQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNAEDVGPIYNNRVE 1040
Query: 296 SCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK--RTAIQHAYRLLISQR 353
+FFI+Y+ + +F+MN+ + V TF + + ++K+ L K R +Q+A +
Sbjct: 1041 MAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKNQRQCVQYALK-----A 1095
Query: 354 RPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAK 413
RP + + + S+ YL F AL NT L ++ +
Sbjct: 1096 RPLRCYIPKNPYQYQVWYIVTSSYFEYLMF-ALIMLNTICLGMQHY-----------NQS 1143
Query: 414 KNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSK 473
+ H D L +IF + +++K AF K +F
Sbjct: 1144 EQMNHISDILNVAFTIIFT-LEMILKLMAF----------------------KARGYFGD 1180
Query: 474 HVPWSYLVFLTIYG--VELFLK-----VAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALA 526
PW+ FL + G +++ L +A G + L G D +
Sbjct: 1181 --PWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESARISSA----- 1233
Query: 527 LNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGM 586
F + R ++L++L E R +L T + + + L +++ ++ +A++GM
Sbjct: 1234 -------FFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGM 1286
Query: 587 EFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVV 646
+ F I + T NR NNF + + LF
Sbjct: 1287 QMFGKIALV---------------DGTQINRN---------NNFQTFPQAVLLLFRCATG 1322
Query: 647 NNWYIIM------------------EGVTSQTSHWSRLYFMTFYIV-TMVVMTIIVAFIL 687
W I+ E T T +++ YF++FY++ +V+ + VA I+
Sbjct: 1323 EAWQEILLACSYGKLCDPESDYAPGEEYTCGT-NFAYYYFISFYMLCAFLVINLFVAVIM 1381
Query: 688 EAF 690
+ F
Sbjct: 1382 DNF 1384
Score = 55.5 bits (132), Expect = 2e-07
Identities = 67/301 (22%), Positives = 124/301 (41%), Gaps = 56/301 (18%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKG-GNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+V+ K F+ + L + N V + V M + N + + FL ++ +E +K+
Sbjct: 47 IVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYFFLIVFSIEAAMKII 106
Query: 496 GLGPV----EYLSSGWNLFDFSVTVFAFLGLLAL--------------------ALNMEP 531
G + YL SGWN+ DF++ FLG+ + L+++
Sbjct: 107 AYGFLFHQDAYLRSGWNVLDFTIV---FLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKA 163
Query: 532 FYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCG 591
VLRPL RL + VL+++F+ + + + L +L +AI+G+E F G
Sbjct: 164 LRAFRVLRPL---RLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKG 220
Query: 592 IVFPNCC-------------NTSTVADAYRWRNHTVGNRTVVEEGY----YYLNNFDNIL 634
+ C S A R T+ N + G+ + + +FDN
Sbjct: 221 KMHKTCYFIGTDIVATVENEEPSPCARTGSGRRCTI-NGSECRGGWPGPNHGITHFDNFG 279
Query: 635 NSFVTLFELTVVNNWYIIMEGVTSQT-SHWSRLYFMT------FYIVTMVVMTIIVAFIL 687
S +T+++ + W ++ V + W +YF+T F+I+ +V+ + F
Sbjct: 280 FSMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTK 339
Query: 688 E 688
E
Sbjct: 340 E 340
Score = 35.0 bits (79), Expect = 0.28
Identities = 35/154 (22%), Positives = 71/154 (46%), Gaps = 32/154 (20%)
Query: 199 RVTRALRCIFLVDCRYCGGVRRNLRQIFQSLP--PFMDILLLLLFFMIIFAILGFYLF-- 254
R+ R +R I L+ GVR L +S P++ +L+++LFF I+A++G +F
Sbjct: 1236 RLFRVMRLIKLLS--RAEGVRTLLWTFIKSFQALPYVALLIVMLFF--IYAVIGMQMFGK 1291
Query: 255 ------SPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMP-SYSR-----------NPWS 296
+ + F T +++ LF T + ++++ SY + ++
Sbjct: 1292 IALVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDPESDYAPGEEYT 1351
Query: 297 C------VFFIVYLSIELYFIMNLLLAVVFDTFN 324
C +FI + + + ++NL +AV+ D F+
Sbjct: 1352 CGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFD 1385
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 98.2 bits (243), Expect = 3e-20
Identities = 153/743 (20%), Positives = 282/743 (37%), Gaps = 175/743 (23%)
Query: 45 HDSQAPSLSSGGESSPSSPAHN--------WEMNYQEAAIYLQEGENNDKFFTHPKDAKA 96
H A L E S H W + + A+YL +N + K
Sbjct: 1235 HREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQ----KV 1290
Query: 97 LAAYLFAHNHLFYLMELATALLLLLLSLCEAPAV-PALRLGIYVHATLELFALMVVVFEL 155
+ +F H L ++ + L E P + P +++ + +F + V E+
Sbjct: 1291 ITHKMFDHVVLVFIFLNCVTIAL------ERPDIDPGSTERVFLSVSNYIFTAIFVA-EM 1343
Query: 156 CMKLRWLGL----HTFIRHKRTMVKTSVLVVQFVEAIVVLV-----RQMSHVRVTRALRC 206
+K+ LGL H +++ ++ +++V V+ +V + + + +RV R LR
Sbjct: 1344 MVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403
Query: 207 IF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFS------PNPS 259
+ L G++ + + SL P +I+L+ F IIF ILG LF P
Sbjct: 1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPD 1463
Query: 260 DPYFST--------------------LENSIVSLFVLLTTANFPDVM-----------MP 288
ST L +++SLFVL + + ++M P
Sbjct: 1464 TRNISTKAQCRAAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGVDQQP 1523
Query: 289 SYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHKRTAIQHAYRL 348
+ NPW ++F ++ LL V F N + +++ ++
Sbjct: 1524 VQNHNPWMLLYF-----------ISFLLIVSFFVLN-----------MFVGVVVENFHKC 1561
Query: 349 LISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAAL 408
Q + A + R+ E +R R+ R R
Sbjct: 1562 --RQHQEAEEARRREEKRLR----RLERRRR----------------------------- 1586
Query: 409 KWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGG 468
KA++ R ++ D P + I+ L S F+ ++ VN + + +E +
Sbjct: 1587 --KAQR-RPYYADYSPTR-----RSIHSLCTSHYLDLFITFIICVNVITMSMEHY--NQP 1636
Query: 469 NFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLL----- 523
+ + + VF ++ E LK+ G + WN D ++ + + +G+
Sbjct: 1637 KSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIE 1696
Query: 524 ---ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYS 580
AL +N + VLR ++L+L K+ R +LDT+ + LP++ +LGL ++ ++
Sbjct: 1697 MSAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFI 1756
Query: 581 FAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTL 640
+A +G+E F + C + EG F N +F+TL
Sbjct: 1757 YAALGVELFGRL---ECSEDNPC------------------EGLSRHATFSNFGMAFLTL 1795
Query: 641 FELTVVNNWYIIMEGVTSQTSH-----------WSRLYFMTFYIVTMVVMTIIVAFILEA 689
F ++ +NW IM+ + S S +YF+TF +V V+ +V +L
Sbjct: 1796 FRVSTGDNWNGIMKDTLRECSREDKHCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMK 1855
Query: 690 FVFRMNYSRKNQDSEVDGGITLE 712
+ N +D+E+D I LE
Sbjct: 1856 HLEESN-KEAREDAELDAEIELE 1877
Score = 83.6 bits (205), Expect = 7e-16
Identities = 70/274 (25%), Positives = 130/274 (47%), Gaps = 36/274 (13%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V SK F + + + VN + + VE + + + S +VF +++ +E+ LK+
Sbjct: 789 IVDSKYFSRGIMMAILVNTLSMGVEYH--EQPEELTNALEISNIVFTSMFALEMLLKLLA 846
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKE---RY 553
GP+ Y+ + +N+FD + V + ++ A + VLR +LLR+ KL
Sbjct: 847 CGPLGYIRNPYNIFDGIIVVISVWEIVGQADGG-----LSVLRTFRLLRVLKLVRFLPAL 901
Query: 554 RNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHT 613
R L + + + +A+ L++F + F+I+GM F C S D T
Sbjct: 902 RRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFG-------CKFSLKTDT----GDT 950
Query: 614 VGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYF---MT 670
V +R NFD++L + VT+F++ +W +++ + TS W+ LYF MT
Sbjct: 951 VPDR----------KNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMT 1000
Query: 671 FYIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
F V+ ++VA ++E F + +R + D +
Sbjct: 1001 F--GNYVLFNLLVAILVEGFQAEGDANRSDTDED 1032
Score = 61.2 bits (147), Expect = 4e-09
Identities = 47/182 (25%), Positives = 89/182 (48%), Gaps = 14/182 (7%)
Query: 154 ELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDCR 213
E+ +KL G +IR+ + ++V+ E + +S +R R LR + LV R
Sbjct: 839 EMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIVGQADGGLSVLRTFRLLRVLKLV--R 896
Query: 214 YCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN-----------PSDPY 262
+ +RR L + +++ LL+ F+ IF+ILG +LF P
Sbjct: 897 FLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKN 956
Query: 263 FSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMNLLLAVVFD 321
F +L +IV++F +LT ++ V+ S + W+ ++F+ ++ Y + NLL+A++ +
Sbjct: 957 FDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVE 1016
Query: 322 TF 323
F
Sbjct: 1017 GF 1018
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/117 (24%), Positives = 53/117 (45%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFL--GLLALALNMEPFYFIVVLRP 540
+ VE+ +K+ LG YL WN DF + V + L +++ + VLRP
Sbjct: 147 FAVEMVIKMVALGLFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHNVSLSAIRTVRVLRP 206
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 207 ---LRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 260
Score = 37.7 bits (86), Expect = 0.043
Identities = 43/183 (23%), Positives = 73/183 (39%), Gaps = 37/183 (20%)
Query: 629 NFDNILNSFVTLFELTVVNNWYIIMEGVTSQTSHWSRLYFMTFYIVTMVVMTIIVAFILE 688
NFDNI +++ +F++ + W IM V S ++ +YF+ IV M I + ++
Sbjct: 360 NFDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSFYNFIYFILLIIVGSFFM-INLCLVVI 418
Query: 689 AFVFRMNYSRKNQDSEVDGGITLEKEISKEELVAVLELYREARGASSDVTRLLETLSQME 748
A F R++Q L + AR S+D T L + S+
Sbjct: 419 ATQFSETKQRESQ----------------------LMREQRARHLSNDST--LASFSEPG 454
Query: 749 RYQQHSMVFLGRRSRTKSDLSLKMYQEEIQEWYEEHAREQEQQRQLSSSAAPAAQQPPGS 808
+ + ++G R SL++Y W ++++ SA Q PG
Sbjct: 455 SCYEELLKYVGHIFRKVKRRSLRLYARWQSRW----------RKKVDPSAVQG--QGPGH 502
Query: 809 RQR 811
RQR
Sbjct: 503 RQR 505
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/71 (22%), Positives = 43/71 (60%), Gaps = 5/71 (7%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 361 FDNIGYAWIAIFQVITLEGWVDIMYYVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 418
Query: 320 FDTFNDIEKRK 330
F++ ++R+
Sbjct: 419 ATQFSETKQRE 429
>gi|38505290 voltage-dependent calcium channel alpha 1G subunit
isoform 13 [Homo sapiens]
Length = 2243
Score = 96.3 bits (238), Expect = 1e-19
Identities = 136/640 (21%), Positives = 243/640 (37%), Gaps = 153/640 (23%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1287 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1342
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1343 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1402
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1403 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1462
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F V + F +
Sbjct: 1463 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF--------VLNMFVGVVV 1514
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
F H+ + A R R+ + L R K R A+
Sbjct: 1515 ENFHKCRQHQEE--EEARR-------------REEKRLRRLEKKRRKAQ----------- 1548
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K +Y Y R LL+ L S F+
Sbjct: 1549 -------CKPYYSDYS--------------------RFRLLVHH----LCTSHYLDLFIT 1577
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1578 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1635
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1636 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1695
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1696 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1735
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1736 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1794
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1795 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1833
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1249 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1308
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1309 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1368
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1369 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1428
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1429 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1474
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1475 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1527
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/190 (25%), Positives = 94/190 (49%), Gaps = 18/190 (9%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF 323
LL+A++ + F
Sbjct: 958 LLVAILVEGF 967
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|38505286 voltage-dependent calcium channel alpha 1G subunit
isoform 10 [Homo sapiens]
Length = 2266
Score = 96.3 bits (238), Expect = 1e-19
Identities = 136/640 (21%), Positives = 243/640 (37%), Gaps = 153/640 (23%)
Query: 133 LRLGIYVHATLELFALMVVVFELCMKLRW-LGLHTFIRHKRTMVKTSVLVVQFVEAIVVL 191
L L Y+ + L + V V + L W G ++R ++ ++++ ++ +V +
Sbjct: 1310 LTLSNYIFTAVFLAEMTVKV----VALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSM 1365
Query: 192 VRQ-----MSHVRVTRALRCIF-LVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMII 245
V + +RV R LR + L G++ + + SL P +I+++ F II
Sbjct: 1366 VSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFII 1425
Query: 246 FAILGFYLFS--------------PNPSDPY------------FSTLENSIVSLFVLLTT 279
F ILG LF N SD F L +++SLFVL +
Sbjct: 1426 FGILGVQLFKGKFFVCQGEDTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFVLASK 1485
Query: 280 ANFPDVM-----------MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEK 328
+ D+M P + NPW ++FI +L I +F V + F +
Sbjct: 1486 DGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFF--------VLNMFVGVVV 1537
Query: 329 RKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLTFKALNQ 388
F H+ + A R R+ + L R K R A+
Sbjct: 1538 ENFHKCRQHQEE--EEARR-------------REEKRLRRLEKKRRKAQ----------- 1571
Query: 389 NNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKAFQYFMY 448
K +Y Y R LL+ L S F+
Sbjct: 1572 -------CKPYYSDYS--------------------RFRLLVHH----LCTSHYLDLFIT 1600
Query: 449 LVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPVEYLSSGWN 508
V+ +N V + +E + + + +F I+ +E K+ G + WN
Sbjct: 1601 GVIGLNVVTMAMEHYQQP--QILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWN 1658
Query: 509 LFDFSVTVFAFLGLL--------ALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTM 560
D ++ + + +G+ +L +N + VLR ++L+L K+ R +LDT+
Sbjct: 1659 QLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTV 1718
Query: 561 FELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVV 620
+ LP++ +LGL ++ ++ FA +G+E F + C T
Sbjct: 1719 MQALPQVGNLGLLFMLLFFIFAALGVELFGDL---ECDETHPC----------------- 1758
Query: 621 EEGYYYLNNFDNILNSFVTLFELTVVNNWYIIMEGV--------TSQTSHWSRLYFMTFY 672
EG F N +F+TLF ++ +NW IM+ T + S +YF++F
Sbjct: 1759 -EGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDQESTCYNTVISPIYFVSFV 1817
Query: 673 IVTMVVMTIIVAFILEAFVFRMNYSRKNQDSEVDGGITLE 712
+ V+ +V +L + N K +++E++ + LE
Sbjct: 1818 LTAQFVLVNVVIAVLMKHLEESNKEAK-EEAELEAELELE 1856
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/297 (23%), Positives = 131/297 (44%), Gaps = 47/297 (15%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
++ K F + + +++ +N + I +E + + + S +F ++ E+ +KV
Sbjct: 1272 IITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVA 1331
Query: 497 LG----PVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQL------LRL 546
LG YL S WN+ D + + + + +L ++ + +LR L+L LR+
Sbjct: 1332 LGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRV 1391
Query: 547 FKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF-------PNCCN 599
+ + V++T+ L + ++ + F+ F I+G++ F G F N N
Sbjct: 1392 ISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVCQGEDTRNITN 1451
Query: 600 TSTVADA-YRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM----- 653
S A+A YRW H NFDN+ + ++LF L + W IM
Sbjct: 1452 KSDCAEASYRWVRHKY--------------NFDNLGQALMSLFVLASKDGWVDIMYDGLD 1497
Query: 654 -EGVTSQT----SHWSRLYFMTF-YIVTMVVMTIIVAFILEAFVFRMNYSRKNQDSE 704
GV Q + W LYF++F IV V+ + V ++E F + R++Q+ E
Sbjct: 1498 AVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENF----HKCRQHQEEE 1550
Score = 73.9 bits (180), Expect = 5e-13
Identities = 55/219 (25%), Positives = 106/219 (48%), Gaps = 35/219 (15%)
Query: 478 SYLVFLTIYGVELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV 537
S +VF +++ +E+ LK+ GP Y+ + +N+FD + V + ++ + + V
Sbjct: 778 SNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVG-----QQGGGLSV 832
Query: 538 LRPLQLLRLFKLKE---RYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVF 594
LR +L+R+ KL + L + + + +A+ + L++F + F+I+GM F G F
Sbjct: 833 LRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLF-GCKF 891
Query: 595 PNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIME 654
+ + T+ D NFD++L + VT+F++ +W ++
Sbjct: 892 ASERDGDTLPDR---------------------KNFDSLLWAIVTVFQILTQEDWNKVLY 930
Query: 655 GVTSQTSHWSRLYF---MTFYIVTMVVMTIIVAFILEAF 690
+ TS W+ LYF MTF V+ ++VA ++E F
Sbjct: 931 NGMASTSSWAALYFIALMTF--GNYVLFNLLVAILVEGF 967
Score = 63.5 bits (153), Expect = 7e-10
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 20/199 (10%)
Query: 145 LFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRAL 204
LFAL E+ +KL G +I++ + ++V+ E + +S +R R +
Sbjct: 785 LFAL-----EMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLM 839
Query: 205 RCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSPN------- 257
R + LV R+ ++R L + +++ +LL+ F+ IF+ILG +LF
Sbjct: 840 RVLKLV--RFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERDG 897
Query: 258 ---PSDPYFSTLENSIVSLFVLLTTANFPDVMMPSY-SRNPWSCVFFIVYLSIELYFIMN 313
P F +L +IV++F +LT ++ V+ S + W+ ++FI ++ Y + N
Sbjct: 898 DTLPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSSWAALYFIALMTFGNYVLFN 957
Query: 314 LLLAVVFDTF--NDIEKRK 330
LL+A++ + F +I KR+
Sbjct: 958 LLVAILVEGFQAEEISKRE 976
Score = 46.6 bits (109), Expect = 9e-05
Identities = 30/117 (25%), Positives = 57/117 (48%), Gaps = 8/117 (6%)
Query: 486 YGVELFLKVAGLGPVE---YLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVV--LRP 540
+ VE+ +K+ LG YL WN DF + + G+L +L+++ F V +R
Sbjct: 128 FAVEMVVKMVALGIFGKKCYLGDTWNRLDFFIVI---AGMLEYSLDLQNVSFSAVRTVRV 184
Query: 541 LQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNC 597
L+ LR R ++ + + LP + ++ L ++ F IVG++ + G++ C
Sbjct: 185 LRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRC 241
Score = 32.3 bits (72), Expect = 1.8
Identities = 27/120 (22%), Positives = 61/120 (50%), Gaps = 12/120 (10%)
Query: 263 FSTLENSIVSLFVLLTTANFPDVM---MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV 319
F + + +++F ++T + D+M M ++S ++ ++FI+ + + +F++NL L V+
Sbjct: 337 FDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSF--YNFIYFILLIIVGSFFMINLCLVVI 394
Query: 320 FDTFNDIEKRKFKSLLLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRF--YKPRMSAR 377
F++ ++R+ L+ +R L S P +E L+++ Y R +AR
Sbjct: 395 ATQFSETKQRE-SQLMREQRVRFLSNASTLASFSEPGSC----YEELLKYLVYILRKAAR 449
>gi|193788732 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 5 [Homo sapiens]
Length = 2166
Score = 80.5 bits (197), Expect = 6e-15
Identities = 79/330 (23%), Positives = 138/330 (41%), Gaps = 41/330 (12%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVET-FMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+V+ K F+ + L + N V + + F N + ++ +FL I+ VE FLKV
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVI 179
Query: 496 GLG----PVEYLSSGWNLFDFSVTVFAFLGLL---------ALALNMEPFYFIV----VL 538
G P YL +GWNL DF + V + A AL + F V
Sbjct: 180 AYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAF 239
Query: 539 RPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCC 598
R L+ LRL + VL+++ + + + + L +L +AI+G+E F G + C
Sbjct: 240 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY 299
Query: 599 NTSTVADA-----------YRWRNHTVGNRTVVEEGY----YYLNNFDNILNSFVTLFEL 643
N +AD N TV + G+ + + NFDN + +T+F+
Sbjct: 300 NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQC 359
Query: 644 TVVNNWYIIMEGVTSQTSH-WSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQD 702
+ W ++ V W +YF+T I+ + +V +L +S++ +
Sbjct: 360 ITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG-----EFSKEREK 414
Query: 703 SEVDGGI--TLEKEISKEELVAVLELYREA 730
++ G EK+ +E+L L+ +A
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQA 444
Score = 73.2 bits (178), Expect = 9e-13
Identities = 112/519 (21%), Positives = 204/519 (39%), Gaps = 96/519 (18%)
Query: 192 VRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGF 251
V+ + RV R LR + V ++ L I +++ P + I LL+LF +II+AI+G
Sbjct: 233 VKALRAFRVLRPLRLVSGVP-----SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 252 YLFS----------------PNPSDPYFSTLEN--------------------------- 268
LF P DP LE
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347
Query: 269 ----SIVSLFVLLTTANFPDVM--MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDT 322
+++++F +T + DV+ + W ++F+ + I +F++NL+L V+
Sbjct: 348 NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGE 407
Query: 323 FNDIEKRKFKSL-----LLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSAR 377
F+ E+ K K+ L K+ + L + I + M KPR +
Sbjct: 408 FSK-EREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 378 ERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINIL 437
T +++N N ++ +A K+K +R +W R +
Sbjct: 467 PTSET-ESVNTENVAGGDIEGENCGARLAHRISKSKFSR-YW----RRWNRFCRRKCRAA 520
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
VKS F + + +V +N + I E + N+ ++ + L ++ E+ LK+ L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHY--NQPNWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYR--- 554
G Y S +N FD V L + + + I VLR ++LLR+FK+ +
Sbjct: 579 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 555 NVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTV 614
N++ ++ + +ASL L L +F F+++GM+ F
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF------------------------- 673
Query: 615 GNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM 653
G + +E + FDN S +T+F++ +W +M
Sbjct: 674 GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM 712
Score = 66.2 bits (160), Expect = 1e-10
Identities = 141/767 (18%), Positives = 276/767 (35%), Gaps = 198/767 (25%)
Query: 31 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH 90
+++ P N + D + P + G P S E++ +E A+ + E
Sbjct: 832 EDKSPYPNPETTGEEDEEEPEMPVGPRPRPLS-----ELHLKEKAVPMPE---------- 876
Query: 91 PKDAKALAAYLFAHNHLFYLM-------ELATALLL---LLLSLCEAPAVPALRLGIYVH 140
A A ++F+ N+ F L + T L+L LL S+ A P H
Sbjct: 877 -----ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH 931
Query: 141 ATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVR---QMSH 197
+ +F + + L+ F+ HK + + ++ + V L+ Q S
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFL-HKGSFCRNYFNILDLLVVSVSLISFGIQSSA 990
Query: 198 VRVTRALRCIFLVD----CRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYL 253
+ V + LR + ++ G++ ++ +F ++ +I+++ +FA +G L
Sbjct: 991 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1050
Query: 254 F--------------------------------------SPNPSDPYFSTLENSIVSLFV 275
F S S F + ++++LF
Sbjct: 1051 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1110
Query: 276 LLTTANFPDVMM-----------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFN 324
+ T +P+++ P Y+ +FFI+Y+ I +F+MN+ + V TF
Sbjct: 1111 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
Query: 325 DIEKRKFKSLLLHK--RTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSARERYLT 382
+ ++++K+ L K R +++A + RP + + + + S YL
Sbjct: 1171 EQGEQEYKNCELDKNQRQCVEYALKA-----RPLRRYIPKNQHQYKVWYVVNSTYFEYLM 1225
Query: 383 FKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINILVKSKA 442
F L NT L+++ + G + L K A
Sbjct: 1226 F-VLILLNTICLAMQHY---------------------------------GQSCLFKI-A 1250
Query: 443 FQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYG--VELFLKVAGLGPV 500
L + V ++++ K +FS PW+ FL + G +++ L
Sbjct: 1251 MNILNMLFTGLFTVEMILKLIAFKPKGYFSD--PWNVFDFLIVIGSIIDVILSETN---- 1304
Query: 501 EYLSSGWNLFDFSVTVFAFLGLLALALNME-----------------PFYFIVVLRPLQL 543
Y WN FD + V + + + +N F + R ++L
Sbjct: 1305 HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFRVMRL 1364
Query: 544 LRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTV 603
++L E R +L T + + + L +++ ++ +A++GM+ F I N +T
Sbjct: 1365 VKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL----NDTTE 1420
Query: 604 ADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM---------- 653
+ RN NNF + + LF W IM
Sbjct: 1421 IN----RN----------------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCA 1460
Query: 654 ---------EGVTSQTSHWSRLYFMTFYIV-TMVVMTIIVAFILEAF 690
EG T S ++ YF++FY++ +++ + VA I++ F
Sbjct: 1461 PESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1507
Score = 60.1 bits (144), Expect = 8e-09
Identities = 61/242 (25%), Positives = 105/242 (43%), Gaps = 23/242 (9%)
Query: 105 NHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGL 164
+++FY + + L L E P + A L AL E+ +K+ LGL
Sbjct: 523 SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTA--EMLLKMYSLGL 580
Query: 165 HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC----RYCGGVRR 220
+ V+ +E I+V + MS + ++ LRC+ L+ RY +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGIS-VLRCVRLLRIFKITRYWNSLSN 639
Query: 221 NLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSP----NPSDPYFSTLEN---SIVSL 273
+ + S+ +LLLL F+IIF++LG LF + ST +N S++++
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 699
Query: 274 FVLLTTANFPDVMM--------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 325
F +LT ++ VM PS+ C++FI+ Y ++N+ LA+ D D
Sbjct: 700 FQILTGEDWNSVMYDGIMAYGGPSFP-GMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Query: 326 IE 327
E
Sbjct: 759 AE 760
Score = 57.4 bits (137), Expect = 5e-08
Identities = 56/256 (21%), Positives = 115/256 (44%), Gaps = 30/256 (11%)
Query: 471 FSKHVPWSY-LVFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDF---SVTVFAFLGL 522
F H+ + + +VF TI+ +E+ LK+ G + + +N+ D SV++ +F G+
Sbjct: 928 FRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GI 986
Query: 523 LALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFA 582
+ A+N+ + VLR L+ LR + ++V+ +F + + ++ + + + FA
Sbjct: 987 QSSAINVVKI--LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 583 IVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN-------FDNILN 635
+G++ F G ++ C ++S +A N+ V+ + FDN+L
Sbjct: 1045 CIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLA 1103
Query: 636 SFVTLFELTVVNNW-YIIMEGVTSQTSHWSRLY--------FMTFYIVTMV--VMTIIVA 684
+ + LF ++ W ++ + S T +Y F YI+ + +M I V
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163
Query: 685 FILEAFVFRMNYSRKN 700
F++ F + KN
Sbjct: 1164 FVIVTFQEQGEQEYKN 1179
Score = 36.6 bits (83), Expect = 0.096
Identities = 31/127 (24%), Positives = 60/127 (47%), Gaps = 31/127 (24%)
Query: 226 FQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPY--------FSTLENSIVSLFVLL 277
FQ+LP ++ +L+++LFF I+A++G +F + F T +++ LF
Sbjct: 1385 FQALP-YVALLIVMLFF--IYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCA 1441
Query: 278 TTANFPDVMM-------------PSYSR-------NPWSCVFFIVYLSIELYFIMNLLLA 317
T + D+M+ PS S + ++ +FI + + + I+NL +A
Sbjct: 1442 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1501
Query: 318 VVFDTFN 324
V+ D F+
Sbjct: 1502 VIMDNFD 1508
>gi|193788730 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 4 [Homo sapiens]
Length = 2173
Score = 80.5 bits (197), Expect = 6e-15
Identities = 79/330 (23%), Positives = 138/330 (41%), Gaps = 41/330 (12%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVET-FMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+V+ K F+ + L + N V + + F N + ++ +FL I+ VE FLKV
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVI 179
Query: 496 GLG----PVEYLSSGWNLFDFSVTVFAFLGLL---------ALALNMEPFYFIV----VL 538
G P YL +GWNL DF + V + A AL + F V
Sbjct: 180 AYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAF 239
Query: 539 RPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCC 598
R L+ LRL + VL+++ + + + + L +L +AI+G+E F G + C
Sbjct: 240 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY 299
Query: 599 NTSTVADA-----------YRWRNHTVGNRTVVEEGY----YYLNNFDNILNSFVTLFEL 643
N +AD N TV + G+ + + NFDN + +T+F+
Sbjct: 300 NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQC 359
Query: 644 TVVNNWYIIMEGVTSQTSH-WSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQD 702
+ W ++ V W +YF+T I+ + +V +L +S++ +
Sbjct: 360 ITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG-----EFSKEREK 414
Query: 703 SEVDGGI--TLEKEISKEELVAVLELYREA 730
++ G EK+ +E+L L+ +A
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQA 444
Score = 73.2 bits (178), Expect = 9e-13
Identities = 112/519 (21%), Positives = 204/519 (39%), Gaps = 96/519 (18%)
Query: 192 VRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGF 251
V+ + RV R LR + V ++ L I +++ P + I LL+LF +II+AI+G
Sbjct: 233 VKALRAFRVLRPLRLVSGVP-----SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 252 YLFS----------------PNPSDPYFSTLEN--------------------------- 268
LF P DP LE
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347
Query: 269 ----SIVSLFVLLTTANFPDVM--MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDT 322
+++++F +T + DV+ + W ++F+ + I +F++NL+L V+
Sbjct: 348 NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGE 407
Query: 323 FNDIEKRKFKSL-----LLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSAR 377
F+ E+ K K+ L K+ + L + I + M KPR +
Sbjct: 408 FSK-EREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 378 ERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINIL 437
T +++N N ++ +A K+K +R +W R +
Sbjct: 467 PTSET-ESVNTENVAGGDIEGENCGARLAHRISKSKFSR-YW----RRWNRFCRRKCRAA 520
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
VKS F + + +V +N + I E + N+ ++ + L ++ E+ LK+ L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHY--NQPNWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYR--- 554
G Y S +N FD V L + + + I VLR ++LLR+FK+ +
Sbjct: 579 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 555 NVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTV 614
N++ ++ + +ASL L L +F F+++GM+ F
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF------------------------- 673
Query: 615 GNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM 653
G + +E + FDN S +T+F++ +W +M
Sbjct: 674 GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM 712
Score = 60.5 bits (145), Expect = 6e-09
Identities = 58/291 (19%), Positives = 116/291 (39%), Gaps = 63/291 (21%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V S F+Y M++++ +N + + ++ + F + ++F ++ VE+ LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALNME-----------------PFYFIVVLR 539
P Y WN FD + V + + + +N F + R
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR 1332
Query: 540 PLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCN 599
++L++L E R +L T + + + L +++ ++ +A++GM+ F I N
Sbjct: 1333 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAL----N 1388
Query: 600 TSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM------ 653
+T + RN NNF + + LF W IM
Sbjct: 1389 DTTEIN----RN----------------NNFQTFPQAVLLLFRCATGEAWQDIMLACMPG 1428
Query: 654 -------------EGVTSQTSHWSRLYFMTFYIV-TMVVMTIIVAFILEAF 690
EG T S ++ YF++FY++ +++ + VA I++ F
Sbjct: 1429 KKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1479
Score = 60.1 bits (144), Expect = 8e-09
Identities = 61/242 (25%), Positives = 105/242 (43%), Gaps = 23/242 (9%)
Query: 105 NHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGL 164
+++FY + + L L E P + A L AL E+ +K+ LGL
Sbjct: 523 SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTA--EMLLKMYSLGL 580
Query: 165 HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC----RYCGGVRR 220
+ V+ +E I+V + MS + ++ LRC+ L+ RY +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGIS-VLRCVRLLRIFKITRYWNSLSN 639
Query: 221 NLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSP----NPSDPYFSTLEN---SIVSL 273
+ + S+ +LLLL F+IIF++LG LF + ST +N S++++
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 699
Query: 274 FVLLTTANFPDVMM--------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 325
F +LT ++ VM PS+ C++FI+ Y ++N+ LA+ D D
Sbjct: 700 FQILTGEDWNSVMYDGIMAYGGPSFP-GMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Query: 326 IE 327
E
Sbjct: 759 AE 760
Score = 53.9 bits (128), Expect = 6e-07
Identities = 53/245 (21%), Positives = 109/245 (44%), Gaps = 29/245 (11%)
Query: 481 VFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDF---SVTVFAFLGLLALALNMEPFY 533
VF +I+ +E+ LK+ G + + +N+ D SV++ +F G+ + A+N+
Sbjct: 939 VFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKI- 996
Query: 534 FIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIV 593
+ VLR L+ LR + ++V+ +F + + ++ + + + FA +G++ F G +
Sbjct: 997 -LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1055
Query: 594 FPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN-------FDNILNSFVTLFELTVV 646
+ C ++S +A N+ V+ + FDN+L + + LF ++
Sbjct: 1056 Y-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTF 1114
Query: 647 NNW-YIIMEGVTSQTSHWSRLY--------FMTFYIVTMV--VMTIIVAFILEAFVFRMN 695
W ++ + S T +Y F YI+ + +M I V F++ F +
Sbjct: 1115 EGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE 1174
Query: 696 YSRKN 700
KN
Sbjct: 1175 QEYKN 1179
Score = 36.6 bits (83), Expect = 0.096
Identities = 31/127 (24%), Positives = 60/127 (47%), Gaps = 31/127 (24%)
Query: 226 FQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPY--------FSTLENSIVSLFVLL 277
FQ+LP ++ +L+++LFF I+A++G +F + F T +++ LF
Sbjct: 1357 FQALP-YVALLIVMLFF--IYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCA 1413
Query: 278 TTANFPDVMM-------------PSYSR-------NPWSCVFFIVYLSIELYFIMNLLLA 317
T + D+M+ PS S + ++ +FI + + + I+NL +A
Sbjct: 1414 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1473
Query: 318 VVFDTFN 324
V+ D F+
Sbjct: 1474 VIMDNFD 1480
>gi|193788728 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 3 [Homo sapiens]
Length = 2179
Score = 80.5 bits (197), Expect = 6e-15
Identities = 79/330 (23%), Positives = 138/330 (41%), Gaps = 41/330 (12%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVET-FMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+V+ K F+ + L + N V + + F N + ++ +FL I+ VE FLKV
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVI 179
Query: 496 GLG----PVEYLSSGWNLFDFSVTVFAFLGLL---------ALALNMEPFYFIV----VL 538
G P YL +GWNL DF + V + A AL + F V
Sbjct: 180 AYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAF 239
Query: 539 RPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCC 598
R L+ LRL + VL+++ + + + + L +L +AI+G+E F G + C
Sbjct: 240 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY 299
Query: 599 NTSTVADA-----------YRWRNHTVGNRTVVEEGY----YYLNNFDNILNSFVTLFEL 643
N +AD N TV + G+ + + NFDN + +T+F+
Sbjct: 300 NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQC 359
Query: 644 TVVNNWYIIMEGVTSQTSH-WSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQD 702
+ W ++ V W +YF+T I+ + +V +L +S++ +
Sbjct: 360 ITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG-----EFSKEREK 414
Query: 703 SEVDGGI--TLEKEISKEELVAVLELYREA 730
++ G EK+ +E+L L+ +A
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQA 444
Score = 73.2 bits (178), Expect = 9e-13
Identities = 112/519 (21%), Positives = 204/519 (39%), Gaps = 96/519 (18%)
Query: 192 VRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGF 251
V+ + RV R LR + V ++ L I +++ P + I LL+LF +II+AI+G
Sbjct: 233 VKALRAFRVLRPLRLVSGVP-----SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 252 YLFS----------------PNPSDPYFSTLEN--------------------------- 268
LF P DP LE
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347
Query: 269 ----SIVSLFVLLTTANFPDVM--MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDT 322
+++++F +T + DV+ + W ++F+ + I +F++NL+L V+
Sbjct: 348 NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGE 407
Query: 323 FNDIEKRKFKSL-----LLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSAR 377
F+ E+ K K+ L K+ + L + I + M KPR +
Sbjct: 408 FSK-EREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 378 ERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINIL 437
T +++N N ++ +A K+K +R +W R +
Sbjct: 467 PTSET-ESVNTENVAGGDIEGENCGARLAHRISKSKFSR-YW----RRWNRFCRRKCRAA 520
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
VKS F + + +V +N + I E + N+ ++ + L ++ E+ LK+ L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHY--NQPNWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYR--- 554
G Y S +N FD V L + + + I VLR ++LLR+FK+ +
Sbjct: 579 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 555 NVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTV 614
N++ ++ + +ASL L L +F F+++GM+ F
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF------------------------- 673
Query: 615 GNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM 653
G + +E + FDN S +T+F++ +W +M
Sbjct: 674 GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM 712
Score = 60.1 bits (144), Expect = 8e-09
Identities = 61/242 (25%), Positives = 105/242 (43%), Gaps = 23/242 (9%)
Query: 105 NHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGL 164
+++FY + + L L E P + A L AL E+ +K+ LGL
Sbjct: 523 SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTA--EMLLKMYSLGL 580
Query: 165 HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC----RYCGGVRR 220
+ V+ +E I+V + MS + ++ LRC+ L+ RY +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGIS-VLRCVRLLRIFKITRYWNSLSN 639
Query: 221 NLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSP----NPSDPYFSTLEN---SIVSL 273
+ + S+ +LLLL F+IIF++LG LF + ST +N S++++
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 699
Query: 274 FVLLTTANFPDVMM--------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 325
F +LT ++ VM PS+ C++FI+ Y ++N+ LA+ D D
Sbjct: 700 FQILTGEDWNSVMYDGIMAYGGPSFP-GMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Query: 326 IE 327
E
Sbjct: 759 AE 760
Score = 57.4 bits (137), Expect = 5e-08
Identities = 56/256 (21%), Positives = 115/256 (44%), Gaps = 30/256 (11%)
Query: 471 FSKHVPWSY-LVFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDF---SVTVFAFLGL 522
F H+ + + +VF TI+ +E+ LK+ G + + +N+ D SV++ +F G+
Sbjct: 928 FRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GI 986
Query: 523 LALALNMEPFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFA 582
+ A+N+ + VLR L+ LR + ++V+ +F + + ++ + + + FA
Sbjct: 987 QSSAINVVKI--LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA 1044
Query: 583 IVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN-------FDNILN 635
+G++ F G ++ C ++S +A N+ V+ + FDN+L
Sbjct: 1045 CIGVQLFKGKLY-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLA 1103
Query: 636 SFVTLFELTVVNNW-YIIMEGVTSQTSHWSRLY--------FMTFYIVTMV--VMTIIVA 684
+ + LF ++ W ++ + S T +Y F YI+ + +M I V
Sbjct: 1104 AMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVG 1163
Query: 685 FILEAFVFRMNYSRKN 700
F++ F + KN
Sbjct: 1164 FVIVTFQEQGEQEYKN 1179
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/313 (18%), Positives = 116/313 (37%), Gaps = 85/313 (27%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAG 496
+V S F+Y M++++ +N + + ++ + F + ++F ++ VE+ LK+
Sbjct: 1215 VVNSTYFEYLMFVLILLNTICLAMQHY--GQSCLFKIAMNILNMLFTGLFTVEMILKLIA 1272
Query: 497 LGPVEYLSSGWNLFDFSVTVFAFLGLLALALN----------MEP--------------- 531
P Y WN FD + V + + + +N M P
Sbjct: 1273 FKPKHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMGPSCSHPPLAVLTAPPV 1332
Query: 532 --------------FYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIF 577
F + R ++L++L E R +L T + + + L +++
Sbjct: 1333 ADGFQNAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVML 1392
Query: 578 YYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSF 637
++ +A++GM+ F I + T NR NNF +
Sbjct: 1393 FFIYAVIGMQVFGKIAL---------------NDTTEINRN---------NNFQTFPQAV 1428
Query: 638 VTLFELTVVNNWYIIM-------------------EGVTSQTSHWSRLYFMTFYIV-TMV 677
+ LF W IM EG T S ++ YF++FY++ +
Sbjct: 1429 LLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFL 1488
Query: 678 VMTIIVAFILEAF 690
++ + VA I++ F
Sbjct: 1489 IINLFVAVIMDNF 1501
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/385 (18%), Positives = 147/385 (38%), Gaps = 89/385 (23%)
Query: 31 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH 90
+++ P N + D + P + G P S E++ +E A+ + E
Sbjct: 832 EDKSPYPNPETTGEEDEEEPEMPVGPRPRPLS-----ELHLKEKAVPMPE---------- 876
Query: 91 PKDAKALAAYLFAHNHLFYLM-------ELATALLL---LLLSLCEAPAVPALRLGIYVH 140
A A ++F+ N+ F L + T L+L LL S+ A P H
Sbjct: 877 -----ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH 931
Query: 141 ATLELFALMVVVFELCMKLRWLGLHTFIRHKRTMVKTSVLVVQFVEAIVVLVR---QMSH 197
+ +F + + L+ F+ HK + + ++ + V L+ Q S
Sbjct: 932 ILFYFDIVFTTIFTIEIALKMTAYGAFL-HKGSFCRNYFNILDLLVVSVSLISFGIQSSA 990
Query: 198 VRVTRALRCIFLVD----CRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYL 253
+ V + LR + ++ G++ ++ +F ++ +I+++ +FA +G L
Sbjct: 991 INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQL 1050
Query: 254 F--------------------------------------SPNPSDPYFSTLENSIVSLFV 275
F S S F + ++++LF
Sbjct: 1051 FKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFT 1110
Query: 276 LLTTANFPDVMM-----------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFN 324
+ T +P+++ P Y+ +FFI+Y+ I +F+MN+ + V TF
Sbjct: 1111 VSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQ 1170
Query: 325 DIEKRKFKSLLLHK--RTAIQHAYR 347
+ ++++K+ L K R +++A +
Sbjct: 1171 EQGEQEYKNCELDKNQRQCVEYALK 1195
Score = 36.6 bits (83), Expect = 0.096
Identities = 31/127 (24%), Positives = 61/127 (48%), Gaps = 31/127 (24%)
Query: 226 FQSLPPFMDILLLLLFFMIIFAILGFYLF--------SPNPSDPYFSTLENSIVSLFVLL 277
FQ+LP ++ +L+++LFF I+A++G +F + + F T +++ LF
Sbjct: 1379 FQALP-YVALLIVMLFF--IYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCA 1435
Query: 278 TTANFPDVMM-------------PSYSR-------NPWSCVFFIVYLSIELYFIMNLLLA 317
T + D+M+ PS S + ++ +FI + + + I+NL +A
Sbjct: 1436 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1495
Query: 318 VVFDTFN 324
V+ D F+
Sbjct: 1496 VIMDNFD 1502
>gi|193788724 calcium channel, voltage-dependent, L type, alpha 1C
subunit isoform 2 [Homo sapiens]
Length = 2186
Score = 80.5 bits (197), Expect = 6e-15
Identities = 79/330 (23%), Positives = 138/330 (41%), Gaps = 41/330 (12%)
Query: 437 LVKSKAFQYFMYLVVAVNGVWILVET-FMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVA 495
+V+ K F+ + L + N V + + F N + ++ +FL I+ VE FLKV
Sbjct: 120 IVEWKPFEIIILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVI 179
Query: 496 GLG----PVEYLSSGWNLFDFSVTVFAFLGLL---------ALALNMEPFYFIV----VL 538
G P YL +GWNL DF + V + A AL + F V
Sbjct: 180 AYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAF 239
Query: 539 RPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCC 598
R L+ LRL + VL+++ + + + + L +L +AI+G+E F G + C
Sbjct: 240 RVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCY 299
Query: 599 NTSTVADA-----------YRWRNHTVGNRTVVEEGY----YYLNNFDNILNSFVTLFEL 643
N +AD N TV + G+ + + NFDN + +T+F+
Sbjct: 300 NQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQC 359
Query: 644 TVVNNWYIIMEGVTSQTSH-WSRLYFMTFYIVTMVVMTIIVAFILEAFVFRMNYSRKNQD 702
+ W ++ V W +YF+T I+ + +V +L +S++ +
Sbjct: 360 ITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSG-----EFSKEREK 414
Query: 703 SEVDGGI--TLEKEISKEELVAVLELYREA 730
++ G EK+ +E+L L+ +A
Sbjct: 415 AKARGDFQKLREKQQLEEDLKGYLDWITQA 444
Score = 73.2 bits (178), Expect = 9e-13
Identities = 112/519 (21%), Positives = 204/519 (39%), Gaps = 96/519 (18%)
Query: 192 VRQMSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGF 251
V+ + RV R LR + V ++ L I +++ P + I LL+LF +II+AI+G
Sbjct: 233 VKALRAFRVLRPLRLVSGVP-----SLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGL 287
Query: 252 YLFS----------------PNPSDPYFSTLEN--------------------------- 268
LF P DP LE
Sbjct: 288 ELFMGKMHKTCYNQEGIADVPAEDDPSPCALETGHGRQCQNGTVCKPGWDGPKHGITNFD 347
Query: 269 ----SIVSLFVLLTTANFPDVM--MPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDT 322
+++++F +T + DV+ + W ++F+ + I +F++NL+L V+
Sbjct: 348 NFAFAMLTVFQCITMEGWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGE 407
Query: 323 FNDIEKRKFKSL-----LLHKRTAIQHAYRLLISQRRPAGISYRQFEGLMRFYKPRMSAR 377
F+ E+ K K+ L K+ + L + I + M KPR +
Sbjct: 408 FSK-EREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEEKPRNMSM 466
Query: 378 ERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDELPRTALLIFKGINIL 437
T +++N N ++ +A K+K +R +W R +
Sbjct: 467 PTSET-ESVNTENVAGGDIEGENCGARLAHRISKSKFSR-YW----RRWNRFCRRKCRAA 520
Query: 438 VKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFLTIYGVELFLKVAGL 497
VKS F + + +V +N + I E + N+ ++ + L ++ E+ LK+ L
Sbjct: 521 VKSNVFYWLVIFLVFLNTLTIASEHY--NQPNWLTEVQDTANKALLALFTAEMLLKMYSL 578
Query: 498 GPVEYLSSGWNLFDFSVTVFAFLGLLALALNMEPFYFIVVLRPLQLLRLFKLKERYR--- 554
G Y S +N FD V L + + + I VLR ++LLR+FK+ +
Sbjct: 579 GLQAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLS 638
Query: 555 NVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIVFPNCCNTSTVADAYRWRNHTV 614
N++ ++ + +ASL L L +F F+++GM+ F
Sbjct: 639 NLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLF------------------------- 673
Query: 615 GNRTVVEEGYYYLNNFDNILNSFVTLFELTVVNNWYIIM 653
G + +E + FDN S +T+F++ +W +M
Sbjct: 674 GGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVM 712
Score = 60.1 bits (144), Expect = 8e-09
Identities = 61/242 (25%), Positives = 105/242 (43%), Gaps = 23/242 (9%)
Query: 105 NHLFYLMELATALLLLLLSLCEAPAVPALRLGIYVHATLELFALMVVVFELCMKLRWLGL 164
+++FY + + L L E P + A L AL E+ +K+ LGL
Sbjct: 523 SNVFYWLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTA--EMLLKMYSLGL 580
Query: 165 HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC----RYCGGVRR 220
+ V+ +E I+V + MS + ++ LRC+ L+ RY +
Sbjct: 581 QAYFVSLFNRFDCFVVCGGILETILVETKIMSPLGIS-VLRCVRLLRIFKITRYWNSLSN 639
Query: 221 NLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSP----NPSDPYFSTLEN---SIVSL 273
+ + S+ +LLLL F+IIF++LG LF + ST +N S++++
Sbjct: 640 LVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTV 699
Query: 274 FVLLTTANFPDVMM--------PSYSRNPWSCVFFIVYLSIELYFIMNLLLAVVFDTFND 325
F +LT ++ VM PS+ C++FI+ Y ++N+ LA+ D D
Sbjct: 700 FQILTGEDWNSVMYDGIMAYGGPSFP-GMLVCIYFIILFICGNYILLNVFLAIAVDNLAD 758
Query: 326 IE 327
E
Sbjct: 759 AE 760
Score = 60.1 bits (144), Expect = 8e-09
Identities = 142/786 (18%), Positives = 278/786 (35%), Gaps = 216/786 (27%)
Query: 31 QEELPSKNGGSYAIHDSQAPSLSSGGESSPSSPAHNWEMNYQEAAIYLQEGENNDKFFTH 90
+++ P N + D + P + G P S E++ +E A+ + E
Sbjct: 832 EDKSPYPNPETTGEEDEEEPEMPVGPRPRPLS-----ELHLKEKAVPMPE---------- 876
Query: 91 PKDAKALAAYLFAHNHLFYLM-------ELATALLL---LLLSLCEAPAVPALRLGIYVH 140
A A ++F+ N+ F L + T L+L LL S+ A P H
Sbjct: 877 -----ASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNH 931
Query: 141 ATLELFALMVVVFELCMKLRWLGLHTFI-------------------RHKRTMVKTSVLV 181
+ +F + + L+ LG ++ HK + + +
Sbjct: 932 ILFYFDIVFTTIFTIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNI 991
Query: 182 VQFVEAIVVLVR---QMSHVRVTRALRCIFLVD----CRYCGGVRRNLRQIFQSLPPFMD 234
+ + V L+ Q S + V + LR + ++ G++ ++ +F ++ +
Sbjct: 992 LDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1051
Query: 235 ILLLLLFFMIIFAILGFYLF--------------------------------------SP 256
I+++ +FA +G LF S
Sbjct: 1052 IVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSW 1111
Query: 257 NPSDPYFSTLENSIVSLFVLLTTANFPDVMM-----------PSYSRNPWSCVFFIVYLS 305
S F + ++++LF + T +P+++ P Y+ +FFI+Y+
Sbjct: 1112 ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYII 1171
Query: 306 IELYFIMNLLLAVVFDTFNDIEKRKFKSLLLHK--RTAIQHAYRLLISQRRPAGISYRQF 363
I +F+MN+ + V TF + ++++K+ L K R +++A + RP +
Sbjct: 1172 IIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKA-----RPLRRYIPKN 1226
Query: 364 EGLMRFYKPRMSARERYLTFKALNQNNTPLLSLKDFYDIYEVAALKWKAKKNREHWFDEL 423
+ + + S YL F L NT L+++ +
Sbjct: 1227 QHQYKVWYVVNSTYFEYLMF-VLILLNTICLAMQHY------------------------ 1261
Query: 424 PRTALLIFKGINILVKSKAFQYFMYLVVAVNGVWILVETFMLKGGNFFSKHVPWSYLVFL 483
G + L K A L + V ++++ K +FS PW+ FL
Sbjct: 1262 ---------GQSCLFKI-AMNILNMLFTGLFTVEMILKLIAFKPKGYFSD--PWNVFDFL 1309
Query: 484 TIYG--VELFLKVAGLGPVEYLSSGWNLFDFSVTVFAFLGLLALALNME----------- 530
+ G +++ L Y WN FD + V + + + +N
Sbjct: 1310 IVIGSIIDVILSETN----HYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNA 1365
Query: 531 ------PFYFIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIV 584
F + R ++L++L E R +L T + + + L +++ ++ +A++
Sbjct: 1366 EENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVI 1425
Query: 585 GMEFFCGIVFPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNNFDNILNSFVTLFELT 644
GM+ F I N +T + RN NNF + + LF
Sbjct: 1426 GMQVFGKIAL----NDTTEIN----RN----------------NNFQTFPQAVLLLFRCA 1461
Query: 645 VVNNWYIIM-------------------EGVTSQTSHWSRLYFMTFYIV-TMVVMTIIVA 684
W IM EG T S ++ YF++FY++ +++ + VA
Sbjct: 1462 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1521
Query: 685 FILEAF 690
I++ F
Sbjct: 1522 VIMDNF 1527
Score = 53.9 bits (128), Expect = 6e-07
Identities = 53/245 (21%), Positives = 109/245 (44%), Gaps = 29/245 (11%)
Query: 481 VFLTIYGVELFLKVAGLGPV----EYLSSGWNLFDF---SVTVFAFLGLLALALNMEPFY 533
VF +I+ +E+ LK+ G + + +N+ D SV++ +F G+ + A+N+
Sbjct: 959 VFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISF-GIQSSAINVVKI- 1016
Query: 534 FIVVLRPLQLLRLFKLKERYRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGIV 593
+ VLR L+ LR + ++V+ +F + + ++ + + + FA +G++ F G +
Sbjct: 1017 -LRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKL 1075
Query: 594 FPNCCNTSTVADAYRWRNHTVGNRTVVEEGYYYLNN-------FDNILNSFVTLFELTVV 646
+ C ++S +A N+ V+ + FDN+L + + LF ++
Sbjct: 1076 Y-TCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTF 1134
Query: 647 NNW-YIIMEGVTSQTSHWSRLY--------FMTFYIVTMV--VMTIIVAFILEAFVFRMN 695
W ++ + S T +Y F YI+ + +M I V F++ F +
Sbjct: 1135 EGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGE 1194
Query: 696 YSRKN 700
KN
Sbjct: 1195 QEYKN 1199
Score = 36.6 bits (83), Expect = 0.096
Identities = 31/127 (24%), Positives = 60/127 (47%), Gaps = 31/127 (24%)
Query: 226 FQSLPPFMDILLLLLFFMIIFAILGFYLFSPNPSDPY--------FSTLENSIVSLFVLL 277
FQ+LP ++ +L+++LFF I+A++G +F + F T +++ LF
Sbjct: 1405 FQALP-YVALLIVMLFF--IYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFRCA 1461
Query: 278 TTANFPDVMM-------------PSYSR-------NPWSCVFFIVYLSIELYFIMNLLLA 317
T + D+M+ PS S + ++ +FI + + + I+NL +A
Sbjct: 1462 TGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVA 1521
Query: 318 VVFDTFN 324
V+ D F+
Sbjct: 1522 VIMDNFD 1528
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.139 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,095,167
Number of Sequences: 37866
Number of extensions: 1215955
Number of successful extensions: 7892
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 90
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 6372
Number of HSP's gapped (non-prelim): 984
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.