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Search of human proteins with 29568105
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
(380 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29568105 transmembrane protein with EGF-like and two follista... 812 0.0
gi|12383051 transmembrane protein with EGF-like and two follista... 389 e-108
gi|54873613 agrin [Homo sapiens] 97 2e-20
gi|5453652 follistatin isoform FST317 precursor [Homo sapiens] 69 7e-12
gi|7242222 follistatin isoform FST344 precursor [Homo sapiens] 69 7e-12
gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens] 69 9e-12
gi|4502461 betacellulin [Homo sapiens] 67 2e-11
gi|153791414 transforming growth factor, alpha isoform 2 [Homo s... 61 2e-09
gi|4507461 transforming growth factor, alpha isoform 1 [Homo sap... 61 2e-09
gi|190358524 follistatin-like 5 isoform c [Homo sapiens] 60 3e-09
gi|190358522 follistatin-like 5 isoform b [Homo sapiens] 60 3e-09
gi|190358520 follistatin-like 5 isoform a [Homo sapiens] 60 3e-09
gi|54792136 follistatin-like 4 [Homo sapiens] 59 9e-09
gi|61806622 epithelial mitogen [Homo sapiens] 56 5e-08
gi|4502199 amphiregulin preproprotein [Homo sapiens] 54 2e-07
gi|113415639 PREDICTED: amphiregulin B [Homo sapiens] 54 2e-07
gi|4557567 epiregulin preproprotein [Homo sapiens] 52 7e-07
gi|4758832 neuregulin 2 isoform 1 [Homo sapiens] 51 2e-06
gi|4557679 jagged 1 precursor [Homo sapiens] 50 3e-06
gi|7669532 neuregulin 2 isoform 4 [Homo sapiens] 50 3e-06
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 50 3e-06
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 50 3e-06
gi|7669528 neuregulin 2 isoform 2 [Homo sapiens] 50 3e-06
gi|148833508 notch1 preproprotein [Homo sapiens] 49 6e-06
gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b p... 49 7e-06
gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a ... 49 7e-06
gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens] 49 1e-05
gi|7669530 neuregulin 2 isoform 3 [Homo sapiens] 48 1e-05
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa... 47 2e-05
gi|24041035 notch 2 preproprotein [Homo sapiens] 47 3e-05
>gi|29568105 transmembrane protein with EGF-like and two
follistatin-like domains 1 [Homo sapiens]
Length = 380
Score = 812 bits (2098), Expect = 0.0
Identities = 380/380 (100%), Positives = 380/380 (100%)
Query: 1 MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGK 60
MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGK
Sbjct: 1 MGAAAAEAPLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQPPGGGGGSGGDCPGGKGK 60
Query: 61 SINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQN 120
SINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQN
Sbjct: 61 SINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQN 120
Query: 121 ECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECD 180
ECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECD
Sbjct: 121 ECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECD 180
Query: 181 EDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD 240
EDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD
Sbjct: 181 EDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD 240
Query: 241 TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCR 300
TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCR
Sbjct: 241 TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCR 300
Query: 301 CESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNR 360
CESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNR
Sbjct: 301 CESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNR 360
Query: 361 GRRQKQNLGHFTSDTSSRMV 380
GRRQKQNLGHFTSDTSSRMV
Sbjct: 361 GRRQKQNLGHFTSDTSSRMV 380
>gi|12383051 transmembrane protein with EGF-like and two
follistatin-like domains 2 [Homo sapiens]
Length = 374
Score = 389 bits (999), Expect = e-108
Identities = 171/316 (54%), Positives = 236/316 (74%), Gaps = 2/316 (0%)
Query: 63 NCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNEC 122
NCS + RE+D+ +CD ++CK+ G C GD + C CQF+C+ +Y+PVCGSNG++YQNEC
Sbjct: 55 NCSGYDDRENDLFLCDTNTCKFDGECLRIGDTVTCVCQFKCNNDYVPVCGSNGESYQNEC 114
Query: 123 FLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDED 182
+LR+AACK Q EI V++ G C +D GSGSG+G EGSG ++ S C C++ AECDED
Sbjct: 115 YLRQAACKQQSEILVVSEGSCATDAGSGSGDGVHEGSGETSQKETSTCDICQFGAECDED 174
Query: 183 AENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTS 242
AE+V CVCNIDCS +FNP+CASDG SY+N C ++EASC KQE+I++ LG C D+T+
Sbjct: 175 AEDVWCVCNIDCSQTNFNPLCASDGKSYDNACQIKEASCQKQEKIEVMSLGRC--QDNTT 232
Query: 243 LLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCE 302
K +DG R D + +++ E+ +H+PCPE+ NG+C+HGKCE + Q+ SCRC+
Sbjct: 233 TTTKSEDGHYARTDYAENANKLEESAREHHIPCPEHYNGFCMHGKCEHSINMQEPSCRCD 292
Query: 303 SGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGR 362
+GYTGQHCEK D+S+LYVVP + +VLIAA+IG +QIA+I +V+CITRKCP++NR
Sbjct: 293 AGYTGQHCEKKDYSVLYVVPGPVRFQYVLIAAVIGTIQIAVICVVVLCITRKCPRSNRIH 352
Query: 363 RQKQNLGHFTSDTSSR 378
RQKQN GH++SD ++R
Sbjct: 353 RQKQNTGHYSSDNTTR 368
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 97.4 bits (241), Expect = 2e-20
Identities = 57/161 (35%), Positives = 80/161 (49%), Gaps = 14/161 (8%)
Query: 77 CDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEIT 136
C ++ C +G VC +C C H PVCGS+G TY + C LR AAC Q +I
Sbjct: 602 CGDAVCAFGAVCSAG----QCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIE 657
Query: 137 VIARGPC-YSDNGSG-SGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDC 194
GPC ++ GSG SG GE+ E+ R+ DED+E+ CVC+ C
Sbjct: 658 EARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIW--------DEDSEDGPCVCDFSC 709
Query: 195 SGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHC 235
+PVC SDG +Y+ C +++A C Q + + G C
Sbjct: 710 QSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGAC 750
Score = 89.0 bits (219), Expect = 7e-18
Identities = 50/165 (30%), Positives = 73/165 (44%), Gaps = 25/165 (15%)
Query: 77 CDESSCKYGGVCKEDGDG---LKCACQFQ-CHTNYIPVCGSNGDTYQNECFLRRAACKHQ 132
C C +G VC+ + +G C C+ C + PVCGS+ TY NEC L+RA C Q
Sbjct: 172 CRGMLCGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQ 231
Query: 133 KEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENV--GCVC 190
+ I +++RGPC S R C + + C A+ + C+C
Sbjct: 232 RRIRLLSRGPCGS-------------------RDPCSNVTCSFGSTCARSADGLTASCLC 272
Query: 191 NIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHC 235
C G VC SDG+ Y C + +C +QE + + G C
Sbjct: 273 PATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPC 317
Score = 89.0 bits (219), Expect = 7e-18
Identities = 50/164 (30%), Positives = 68/164 (41%), Gaps = 27/164 (16%)
Query: 77 CDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEIT 136
C C +G C C C C + Y PVCGS+G TY + C L AC +EI
Sbjct: 468 CLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQ 527
Query: 137 VIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSG 196
V +GPC +CG C++ A C +AE CVC +C
Sbjct: 528 VARKGPC------------------------DRCGQCRFGALC--EAETGRCVCPSECVA 561
Query: 197 YSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD 240
+ PVC SDG +Y + C + +C Q + + G C D
Sbjct: 562 LA-QPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGD 604
Score = 87.8 bits (216), Expect = 1e-17
Identities = 53/166 (31%), Positives = 74/166 (44%), Gaps = 34/166 (20%)
Query: 77 CDE-SSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEI 135
CD C++G +C+ + +C C +C PVCGS+G TY +EC L AC HQ +
Sbjct: 534 CDRCGQCRFGALCEAETG--RCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISL 591
Query: 136 TVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGP--CKYKAECDEDAENVGCVCNID 193
V + GPC + CG C + A C CVC
Sbjct: 592 HVASAGPCET------------------------CGDAVCAFGAVCSAGQ----CVCP-R 622
Query: 194 CSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTD 239
C PVC SDG +Y + C +REA+C++Q QI+ G C +
Sbjct: 623 CEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAE 668
Score = 70.1 bits (170), Expect = 3e-12
Identities = 40/134 (29%), Positives = 62/134 (46%), Gaps = 22/134 (16%)
Query: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
C PVCG +G TY+N+C + R+ ARG SG +G ++
Sbjct: 349 CPARQAPVCGDDGVTYENDCVMGRSGA---------ARGLLLQKVRSGQCQGRDQCPE-- 397
Query: 163 VHRKHSKCGPCKYKAECDEDAENVGCVCN-IDCSGYSFNPVCASDGSSYNNPCFVREASC 221
PC++ A C C C+ + C G ++ PVCA DG +Y++ C+ ++A C
Sbjct: 398 ---------PCRFNAVCLSRRGRPRCSCDRVTCDG-AYRPVCAQDGRTYDSDCWRQQAEC 447
Query: 222 IKQEQIDIRHLGHC 235
+Q I +H G C
Sbjct: 448 RQQRAIPSKHQGPC 461
Score = 65.9 bits (159), Expect = 6e-11
Identities = 35/102 (34%), Positives = 49/102 (48%), Gaps = 4/102 (3%)
Query: 44 PGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCAC-QFQ 102
PG G G CP G+ ++ + S C E C++G C E+ C C
Sbjct: 870 PGVAGPKCGQCPDGR--ALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLT 927
Query: 103 C-HTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPC 143
C N VCGS+G TY NEC L+ AC+ +I++ + GPC
Sbjct: 928 CPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPC 969
Score = 51.2 bits (121), Expect = 2e-06
Identities = 55/241 (22%), Positives = 87/241 (36%), Gaps = 42/241 (17%)
Query: 8 APLRLPAAPPLAFCCYTSVLLLFAFSLPGSRASNQ--PPGGGGGS----GGDC---PGGK 58
APL P CC ++ L G ++ Q P G GG+ G C PG
Sbjct: 762 APLHCAQTP--YGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVG 819
Query: 59 GKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLK-CACQFQCHTNYIPVCGSNGDT 117
G + C C+ + G+ + G C+C Q
Sbjct: 820 G--LRCDR----------CEPGFWNFRGIVTDGRSGCTPCSCDPQ-------------GA 854
Query: 118 YQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKA 177
+++C C + + G C G E + S + C++ A
Sbjct: 855 VRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMR----CEFGA 910
Query: 178 ECDEDAENVGCVCN-IDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCT 236
C E++ + CVC + C + VC SDG +Y N C ++ +C + QI I+ LG C
Sbjct: 911 RCVEESGSAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQ 970
Query: 237 D 237
+
Sbjct: 971 E 971
Score = 49.7 bits (117), Expect = 4e-06
Identities = 26/73 (35%), Positives = 36/73 (49%), Gaps = 3/73 (4%)
Query: 173 CKYKAECDEDAENVG---CVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDI 229
C + A C+ +AE G CVC PVC SD S+Y+N C ++ A C +Q +I +
Sbjct: 177 CGFGAVCEPNAEGPGRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRL 236
Query: 230 RHLGHCTDTDDTS 242
G C D S
Sbjct: 237 LSRGPCGSRDPCS 249
>gi|5453652 follistatin isoform FST317 precursor [Homo sapiens]
Length = 317
Score = 68.9 bits (167), Expect = 7e-12
Identities = 54/187 (28%), Positives = 77/187 (41%), Gaps = 37/187 (19%)
Query: 56 GGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGL-KCACQFQCH--TNYIPVCG 112
GG I C E C+ C G C+ + +C C C T PVCG
Sbjct: 83 GGAPNCIPCKE---------TCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCG 133
Query: 113 SNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGP 172
+G TY+NEC L +A CK Q E+ V +G C +K +
Sbjct: 134 LDGKTYRNECALLKARCKEQPELEVQYQGRC---------------------KKTCRDVF 172
Query: 173 CKYKAECDED-AENVGCV-CNIDC--SGYSFNPVCASDGSSYNNPCFVREASCIKQEQID 228
C + C D N CV CN C S +C +DG +Y++ C +R+A+C+ I
Sbjct: 173 CPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIG 232
Query: 229 IRHLGHC 235
+ + G C
Sbjct: 233 LAYEGKC 239
Score = 52.4 bits (124), Expect = 7e-07
Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 5/71 (7%)
Query: 170 CGPCKYKAECDEDAENVG-CVCNIDCSGYSFN-PVCASDGSSYNNPCFVREASCIKQEQI 227
CGP K +C + +N CVC DCS ++ PVC DG +Y N C + +A C +Q ++
Sbjct: 100 CGPGK---KCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPEL 156
Query: 228 DIRHLGHCTDT 238
++++ G C T
Sbjct: 157 EVQYQGRCKKT 167
Score = 37.0 bits (84), Expect = 0.029
Identities = 23/72 (31%), Positives = 31/72 (43%), Gaps = 5/72 (6%)
Query: 77 CDESSCKYGGVCKED---GDGLKCACQFQCHTNYI--PVCGSNGDTYQNECFLRRAACKH 131
C++ C G C D G G C C + PVC S+ TY +EC ++ AAC
Sbjct: 245 CEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSS 304
Query: 132 QKEITVIARGPC 143
+ V G C
Sbjct: 305 GVLLEVKHSGSC 316
>gi|7242222 follistatin isoform FST344 precursor [Homo sapiens]
Length = 344
Score = 68.9 bits (167), Expect = 7e-12
Identities = 54/187 (28%), Positives = 77/187 (41%), Gaps = 37/187 (19%)
Query: 56 GGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGL-KCACQFQCH--TNYIPVCG 112
GG I C E C+ C G C+ + +C C C T PVCG
Sbjct: 83 GGAPNCIPCKE---------TCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCG 133
Query: 113 SNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGP 172
+G TY+NEC L +A CK Q E+ V +G C +K +
Sbjct: 134 LDGKTYRNECALLKARCKEQPELEVQYQGRC---------------------KKTCRDVF 172
Query: 173 CKYKAECDED-AENVGCV-CNIDC--SGYSFNPVCASDGSSYNNPCFVREASCIKQEQID 228
C + C D N CV CN C S +C +DG +Y++ C +R+A+C+ I
Sbjct: 173 CPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIG 232
Query: 229 IRHLGHC 235
+ + G C
Sbjct: 233 LAYEGKC 239
Score = 52.4 bits (124), Expect = 7e-07
Identities = 26/71 (36%), Positives = 41/71 (57%), Gaps = 5/71 (7%)
Query: 170 CGPCKYKAECDEDAENVG-CVCNIDCSGYSFN-PVCASDGSSYNNPCFVREASCIKQEQI 227
CGP K +C + +N CVC DCS ++ PVC DG +Y N C + +A C +Q ++
Sbjct: 100 CGPGK---KCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPEL 156
Query: 228 DIRHLGHCTDT 238
++++ G C T
Sbjct: 157 EVQYQGRCKKT 167
Score = 40.4 bits (93), Expect = 0.003
Identities = 27/86 (31%), Positives = 37/86 (43%), Gaps = 5/86 (5%)
Query: 77 CDESSCKYGGVCKED---GDGLKCACQFQCHTNYI--PVCGSNGDTYQNECFLRRAACKH 131
C++ C G C D G G C C + PVC S+ TY +EC ++ AAC
Sbjct: 245 CEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSS 304
Query: 132 QKEITVIARGPCYSDNGSGSGEGEEE 157
+ V G C S + E E+E
Sbjct: 305 GVLLEVKHSGSCNSISEDTEEEEEDE 330
>gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]
Length = 263
Score = 68.6 bits (166), Expect = 9e-12
Identities = 46/171 (26%), Positives = 70/171 (40%), Gaps = 28/171 (16%)
Query: 77 CDESSCKYGGVCKEDGDGLKCACQFQCH--TNYIPVCGSNGDTYQNECFLRRAACKHQKE 134
CD C G C+ G +C C C + VCGS+G TY++EC LR A C+ +
Sbjct: 99 CDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPD 158
Query: 135 ITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAEC--DEDAENVGCVCNI 192
++V+ RG C RK + C C D+ VC
Sbjct: 159 LSVMYRGRC---------------------RKSCEHVVCPRPQSCVVDQTGSAHCVVCRA 197
Query: 193 DCSGYSFNP---VCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDD 240
+P +C ++ +Y + C +R+A+C I +RH G C T +
Sbjct: 198 APCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPE 248
Score = 32.0 bits (71), Expect = 0.95
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 5/53 (9%)
Query: 110 VCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
+CG+N TY + C +R+A C + I V G C +G+ E G AE
Sbjct: 210 LCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSC-----AGTPEEPPGGESAE 257
>gi|4502461 betacellulin [Homo sapiens]
Length = 178
Score = 67.4 bits (163), Expect = 2e-11
Identities = 38/134 (28%), Positives = 61/134 (45%), Gaps = 6/134 (4%)
Query: 234 HCTDTDDTSLLGKKDDGLQYR-PDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIY 292
HC D S + +GL P+ A+ + G+ CP+ YCI G+C F+
Sbjct: 27 HCVVADGNSTRSPETNGLLCGDPEENCAATTTQSKRKGHFSRCPKQYKHYCIKGRCRFVV 86
Query: 293 STQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAAIIGAVQIAIIVAIVMCIT 352
+ Q SC C+ GY G CE+ D L R +L+ +I + + II+ I +C
Sbjct: 87 AEQTPSCVCDEGYIGARCERVDLFYL-----RGDRGQILVICLIAVMVVFIILVIGVCTC 141
Query: 353 RKCPKNNRGRRQKQ 366
+ R R++K+
Sbjct: 142 CHPLRKRRKRKKKE 155
>gi|153791414 transforming growth factor, alpha isoform 2 [Homo
sapiens]
Length = 159
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAA 334
CP++ +C HG C F+ K +C C SGY G CE D +L VV + QK +
Sbjct: 46 CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAITALV 103
Query: 335 IIGAVQIAIIVAIVMCITRKC 355
++ V +A++ I+ C+ C
Sbjct: 104 VVSIVALAVL--IITCVLIHC 122
>gi|4507461 transforming growth factor, alpha isoform 1 [Homo
sapiens]
Length = 160
Score = 60.8 bits (146), Expect = 2e-09
Identities = 27/81 (33%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAA 334
CP++ +C HG C F+ K +C C SGY G CE D +L VV + QK +
Sbjct: 47 CPDSHTQFCFHGTCRFLVQEDKPACVCHSGYVGARCEHAD--LLAVVAASQKKQAITALV 104
Query: 335 IIGAVQIAIIVAIVMCITRKC 355
++ V +A++ I+ C+ C
Sbjct: 105 VVSIVALAVL--IITCVLIHC 123
>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
Length = 837
Score = 60.1 bits (144), Expect = 3e-09
Identities = 27/71 (38%), Positives = 41/71 (57%), Gaps = 4/71 (5%)
Query: 77 CDESSCKYGGVC---KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQK 133
C+ C G C +E G +CAC C +Y PVCGS+G+ Y+N C + RAAC ++
Sbjct: 64 CENKYCGLGRHCVTSRETGQA-ECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQ 122
Query: 134 EITVIARGPCY 144
+IT++ C+
Sbjct: 123 KITIVHNEDCF 133
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 188 CVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHC 235
C C C + + PVC SDG Y N C V A+C+K+++I I H C
Sbjct: 86 CACMDLCKRH-YKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDC 132
>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
Length = 846
Score = 60.1 bits (144), Expect = 3e-09
Identities = 27/71 (38%), Positives = 41/71 (57%), Gaps = 4/71 (5%)
Query: 77 CDESSCKYGGVC---KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQK 133
C+ C G C +E G +CAC C +Y PVCGS+G+ Y+N C + RAAC ++
Sbjct: 64 CENKYCGLGRHCVTSRETGQA-ECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQ 122
Query: 134 EITVIARGPCY 144
+IT++ C+
Sbjct: 123 KITIVHNEDCF 133
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 188 CVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHC 235
C C C + + PVC SDG Y N C V A+C+K+++I I H C
Sbjct: 86 CACMDLCKRH-YKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDC 132
>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
Length = 847
Score = 60.1 bits (144), Expect = 3e-09
Identities = 27/71 (38%), Positives = 41/71 (57%), Gaps = 4/71 (5%)
Query: 77 CDESSCKYGGVC---KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQK 133
C+ C G C +E G +CAC C +Y PVCGS+G+ Y+N C + RAAC ++
Sbjct: 65 CENKYCGLGRHCVTSRETGQA-ECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQ 123
Query: 134 EITVIARGPCY 144
+IT++ C+
Sbjct: 124 KITIVHNEDCF 134
Score = 44.7 bits (104), Expect = 1e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 1/48 (2%)
Query: 188 CVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHC 235
C C C + + PVC SDG Y N C V A+C+K+++I I H C
Sbjct: 87 CACMDLCKRH-YKPVCGSDGEFYENHCEVHRAACLKKQKITIVHNEDC 133
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 58.5 bits (140), Expect = 9e-09
Identities = 29/71 (40%), Positives = 39/71 (54%), Gaps = 4/71 (5%)
Query: 77 CDESSCKYGGVC---KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQK 133
C + C G C ++ G+ +C C C +Y+PVCGS+G Y+N C L RAAC K
Sbjct: 65 CGKKFCSRGSRCVLSRKTGEP-ECQCLEACRPSYVPVCGSDGRFYENHCKLHRAACLLGK 123
Query: 134 EITVIARGPCY 144
ITVI C+
Sbjct: 124 RITVIHSKDCF 134
Score = 42.0 bits (97), Expect = 0.001
Identities = 36/116 (31%), Positives = 48/116 (41%), Gaps = 18/116 (15%)
Query: 139 ARGPCYSDNGSGSGEGEEEGSGAEVHRKH---------SKCGP--CKYKAEC--DEDAEN 185
+RGP D G G + EE S EV R+ + CG C + C
Sbjct: 29 SRGP---DVGVGESQAEEPRS-FEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGE 84
Query: 186 VGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDT 241
C C C S+ PVC SDG Y N C + A+C+ ++I + H C DT
Sbjct: 85 PECQCLEACRP-SYVPVCGSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDT 139
>gi|61806622 epithelial mitogen [Homo sapiens]
Length = 133
Score = 56.2 bits (134), Expect = 5e-08
Identities = 31/80 (38%), Positives = 44/80 (55%), Gaps = 4/80 (5%)
Query: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLTHVLIAA 334
C E+ N YCI+G C F + +KA CRC +GYTG+ CE + Y V S +K ++ I
Sbjct: 51 CLEDHNSYCINGACAFHHELEKAICRCFTGYTGERCEHLTLT-SYAVDSYEK--YIAIGI 107
Query: 335 IIGAVQIAIIVAIVMCITRK 354
+G + +V I C RK
Sbjct: 108 GVGLLLSGFLV-IFYCYIRK 126
>gi|4502199 amphiregulin preproprotein [Homo sapiens]
Length = 252
Score = 54.3 bits (129), Expect = 2e-07
Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Query: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHC-EKTDFSILYVVPSRQKLTHVLI 332
PC +CIHG+C++I + +C+C+ Y G+ C EK+ + + S K+ I
Sbjct: 145 PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAI 204
Query: 333 AAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQ 366
AA + AV + + I + + R+ + G +++
Sbjct: 205 AAFMSAVILTAVAVITVQLRRQYVRKYEGEAEER 238
>gi|113415639 PREDICTED: amphiregulin B [Homo sapiens]
Length = 252
Score = 54.3 bits (129), Expect = 2e-07
Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 1/94 (1%)
Query: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHC-EKTDFSILYVVPSRQKLTHVLI 332
PC +CIHG+C++I + +C+C+ Y G+ C EK+ + + S K+ I
Sbjct: 145 PCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAI 204
Query: 333 AAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQ 366
AA + AV + + I + + R+ + G +++
Sbjct: 205 AAFMSAVILTAVAVITVQLRRQYVRKYEGEAEER 238
>gi|4557567 epiregulin preproprotein [Homo sapiens]
Length = 169
Score = 52.4 bits (124), Expect = 7e-07
Identities = 18/37 (48%), Positives = 25/37 (67%)
Query: 275 CPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE 311
C ++NGYC+HG+C ++ + CRCE GYTG CE
Sbjct: 68 CSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCE 104
>gi|4758832 neuregulin 2 isoform 1 [Homo sapiens]
Length = 850
Score = 50.8 bits (120), Expect = 2e-06
Identities = 28/101 (27%), Positives = 50/101 (49%), Gaps = 4/101 (3%)
Query: 270 GNHMPCPENLNGYCIHGK-CEFIYSTQKASCRCESGYTGQHCEKTDFSILYVVPSRQKLT 328
G+ C E YC++G C +I + SC+C +G+ GQ C + LY+ +QK
Sbjct: 340 GHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKAE 399
Query: 329 HVLIAAI--IGAVQIAIIVAIVMCITRKCPKNNRGRRQKQN 367
+ + I + +A++V ++C+ C K + R+Q N
Sbjct: 400 ELYQKRVLTITGICVALLVVGIVCVVAYC-KTKKQRKQMHN 439
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 50.4 bits (119), Expect = 3e-06
Identities = 48/199 (24%), Positives = 73/199 (36%), Gaps = 47/199 (23%)
Query: 53 DCPGG-KGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKC---------ACQFQ 102
DC G KGK+ + R+S CDE++C GG C ++GD KC C
Sbjct: 692 DCKNGWKGKTCHS-----RDSQ---CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIA 743
Query: 103 CHTNYIPVCGSNGDT--YQNECFLRRAACKHQKEITVIARG-------PCYSDNGSGSGE 153
+++ +P NG T E F CK E + A+ PCY+ G+
Sbjct: 744 RNSSCLPNPCHNGGTCVVNGESF--TCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGD 801
Query: 154 GEEE--------GSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCA- 204
G ++ + PC + A C ++ CVC SG V
Sbjct: 802 NWYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGR 861
Query: 205 ---------SDGSSYNNPC 214
DG+ +++ C
Sbjct: 862 PCITMGSVIPDGAKWDDDC 880
Score = 43.9 bits (102), Expect = 2e-04
Identities = 70/325 (21%), Positives = 105/325 (32%), Gaps = 101/325 (31%)
Query: 39 ASNQPPGGGG-------GSGGDCPGGKGKSINCS-----ELNVRESDVRVCDESSCKYGG 86
ASN P G G G C G C ++ C+ + C+ GG
Sbjct: 583 ASNDTPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGG 642
Query: 87 VCKEDGDGLKCACQ-----FQCHTNYIPVCGS----NGDTYQN----------------E 121
C + + KC C C TN I C NG T ++
Sbjct: 643 TCIDGVNSYKCICSDGWEGAYCETN-INDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKT 701
Query: 122 CFLRRAACKHQKEITVIARGPCYSDNGSGS--GEGEEEGSGAEVHRKHSKC--GPCKYKA 177
C R + C E T G CY + + G EG+ + R +S C PC
Sbjct: 702 CHSRDSQC---DEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNIAR-NSSCLPNPCHNGG 757
Query: 178 ECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYN-NPCFVREASCIKQEQIDIRHLGHCT 236
C + E+ CVC G P+CA + + + +PC+ + G C
Sbjct: 758 TCVVNGESFTCVCKEGWEG----PICAQNTNDCSPHPCY---------------NSGTCV 798
Query: 237 DTDDTSLLGKKDDGLQYR---------PDVKDASDQREDVYIGNHMPCPENLNGYCIHGK 287
D D+ YR PD + ++ + C + +NGY
Sbjct: 799 DGDN-----------WYRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGY----- 842
Query: 288 CEFIYSTQKASCRCESGYTGQHCEK 312
C C G++G C++
Sbjct: 843 ----------RCVCPPGHSGAKCQE 857
Score = 40.8 bits (94), Expect = 0.002
Identities = 60/279 (21%), Positives = 91/279 (32%), Gaps = 71/279 (25%)
Query: 77 CDESSCKYGGVCKEDGDGLKCACQFQ------------CHT--------------NYIPV 110
C ++C +GG C++ +G KC C Q C +Y
Sbjct: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
Query: 111 C-----GSNGDTYQNECFLRRAACKHQKEITVIARG-PCYSDNGSGSGEGEEEGSGAEVH 164
C G N D N+C C++ + G C G +G
Sbjct: 438 CLPGWMGQNCDININDCL---GQCQNDASCRDLVNGYRCICPPGY---------AGDHCE 485
Query: 165 RKHSKCG--PCKYKAECDEDAENVGCVCNIDCSG--------YSFNPVCASDGSSYNNPC 214
R +C PC C + C+C SG Y C + YN
Sbjct: 486 RDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNR-- 543
Query: 215 FVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDV-YIGNHM 273
+ C E + ++ H D T+ D ++D E V YI +++
Sbjct: 544 -ASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTV----AMASNDTPEGVRYISSNV 598
Query: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEK 312
P HGKC+ S K +C C G+TG +C +
Sbjct: 599 CGP--------HGKCKS-QSGGKFTCDCNKGFTGTYCHE 628
Score = 34.3 bits (77), Expect = 0.19
Identities = 57/279 (20%), Positives = 88/279 (31%), Gaps = 64/279 (22%)
Query: 77 CDESSCKYG-----GVCKEDGDGLKCACQFQCHTNYIPVC--------GSNGDTYQNECF 123
C+ + C+ G G CK GD C CQ+ Y C G + +Q C
Sbjct: 229 CNRAICRQGCSPKHGSCKLPGD---CRCQYGWQGLYCDKCIPHPGCVHGICNEPWQCLCE 285
Query: 124 LRRAACKHQKEITVIARGPCYSDNGSGSGEGEEE----------GSGAEVHRKHSKCGPC 173
K++ + G+ S G ++ G E+ PC
Sbjct: 286 TNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPC 345
Query: 174 KYKAECDEDAENVGCVCNIDCSGYSFN---PVCASDGSSYNNPC--FVREASCI------ 222
+ C E + C C+ +G + + C+ + S+ C V C+
Sbjct: 346 HNRGSCKETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWT 405
Query: 223 -KQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPD-VKDASDQREDVYIG-------NHM 273
K Q+D C + K+ Y D + Q D+ I N
Sbjct: 406 GKTCQLD---ANECEAKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDA 462
Query: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEK 312
C + +NGY C C GY G HCE+
Sbjct: 463 SCRDLVNGY---------------RCICPPGYAGDHCER 486
Score = 33.5 bits (75), Expect = 0.33
Identities = 19/51 (37%), Positives = 23/51 (45%), Gaps = 8/51 (15%)
Query: 268 YIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSIL 318
Y G H PC LNG G C K C C GY+G +CE + + L
Sbjct: 299 YCGTHQPC---LNG----GTCSNT-GPDKYQCSCPEGYSGPNCEIAEHACL 341
Score = 28.9 bits (63), Expect = 8.0
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 17/64 (26%)
Query: 264 REDVYIGNHMPCPENLNGYCIHG----KCEFIYSTQKAS-----------CRCESGYTGQ 308
R+D + H C +N N C+ G +C Q S CRC+ G+ G
Sbjct: 203 RDDFF--GHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGL 260
Query: 309 HCEK 312
+C+K
Sbjct: 261 YCDK 264
>gi|7669532 neuregulin 2 isoform 4 [Homo sapiens]
Length = 852
Score = 50.4 bits (119), Expect = 3e-06
Identities = 29/104 (27%), Positives = 53/104 (50%), Gaps = 8/104 (7%)
Query: 270 GNHMPCPENLNGYCIHGK-CEFIYSTQKASCRCESGYTGQHCEK---TDFS--ILYVVPS 323
G+ C E YC++G C +I + SC+C GYTG C++ +FS + + +
Sbjct: 340 GHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKHLGFELKE 399
Query: 324 RQKLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQN 367
++L + I G + +A++V ++C+ C K + R+Q N
Sbjct: 400 AEELYQKRVLTITG-ICVALLVVGIVCVVAYC-KTKKQRKQMHN 441
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 50.1 bits (118), Expect = 3e-06
Identities = 72/283 (25%), Positives = 100/283 (35%), Gaps = 47/283 (16%)
Query: 40 SNQPPGGGGG-----SGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDG 94
++ P GG SG +C G S L++ E C + C GG C + DG
Sbjct: 352 TSNPCANGGSCHEVPSGFECHCPSGWSGPTCALDIDE-----CASNPCAAGGTCVDQVDG 406
Query: 95 LKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARG-PCYSDNGSGSGE 153
+C C Q G+ N+C R C+H + G C G G
Sbjct: 407 FECICPEQW-------VGATCQLDVNDC---RGQCQHGGTCKDLVNGYQCVCPRGFG--- 453
Query: 154 GEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYN-N 212
G E+ R PC C++ A+ C C SG P+C D +
Sbjct: 454 ----GRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG----PLCEVDVDLCEPS 505
Query: 213 PCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDV--YIG 270
PC A C E +C DD G K+ + P A + G
Sbjct: 506 PC-RNGARCYNLEGD-----YYCACPDD---FGGKNCSVPREPCPGGACRVIDGCGSDAG 556
Query: 271 NHMPCPENLNGYC-IHGKCEFIYSTQKASCRCESGYTGQHCEK 312
MP +G C HG+C SC C+SG+TG +C +
Sbjct: 557 PGMP-GTAASGVCGPHGRC-VSQPGGNFSCICDSGFTGTYCHE 597
Score = 38.1 bits (87), Expect = 0.013
Identities = 67/309 (21%), Positives = 100/309 (32%), Gaps = 71/309 (22%)
Query: 34 LPGSRASNQPPGGGGGSGGDC---PGGKGKSINCSELNVR--ESDVRVCDESSCKYGGVC 88
+PG+ AS G G G C PGG I S ++ C C+ GG C
Sbjct: 559 MPGTAAS-----GVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTC 613
Query: 89 KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNG 148
++ D +C C G DT N+C C +RG CY
Sbjct: 614 IDEVDAFRCFCPSGWE-------GELCDTNPNDCL--PDPCH--------SRGRCYDLVN 656
Query: 149 SGSGEGEEEGSGAEVHRKHSKCG--PCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASD 206
++ G H + +C C C + + C C G + A +
Sbjct: 657 DFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTC--AVAKN 714
Query: 207 GSSYNNPCF--------VREASCIKQEQIDIRHLGHCTDTDDTSLL-----GKKDDGLQY 253
S NPC SCI ++ + R H +T+D + L G DG+ +
Sbjct: 715 SSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTH--NTNDCNPLPCYNGGICVDGVNW 772
Query: 254 ----------RPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCES 303
PD + D+ + C + +NGY C C
Sbjct: 773 FRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGY---------------RCSCPP 817
Query: 304 GYTGQHCEK 312
G G C++
Sbjct: 818 GRAGPRCQE 826
Score = 37.0 bits (84), Expect = 0.029
Identities = 58/261 (22%), Positives = 84/261 (32%), Gaps = 68/261 (26%)
Query: 77 CDESSCKYG-----GVCKEDGDGLKCACQFQCHTNYIPVC--------GSNGDTYQNECF 123
C E+ CK G G C G+ C C + + C GS + +Q C
Sbjct: 240 CKEAVCKQGCNLLHGGCTVPGE---CRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCE 296
Query: 124 LRRAACKHQKEITVI-ARGPCYSDNGSGSGEGEE------EG-SGAEVHRKHSKC--GPC 173
K++ + PC + + E ++ +G SG + C PC
Sbjct: 297 TNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPC 356
Query: 174 KYKAECDEDAENVGCVCNIDCSGYSFNPVCASD-GSSYNNPCFVREASCIKQEQIDIRHL 232
C E C C SG P CA D +NPC
Sbjct: 357 ANGGSCHEVPSGFECHCPSGWSG----PTCALDIDECASNPCAAG--------------- 397
Query: 233 GHCTDTDD--TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEF 290
G C D D + ++ G + DV D Q + + C + +NGY
Sbjct: 398 GTCVDQVDGFECICPEQWVGATCQLDVNDCRGQCQ-----HGGTCKDLVNGY-------- 444
Query: 291 IYSTQKASCRCESGYTGQHCE 311
C C G+ G+HCE
Sbjct: 445 -------QCVCPRGFGGRHCE 458
Score = 35.0 bits (79), Expect = 0.11
Identities = 16/47 (34%), Positives = 25/47 (53%), Gaps = 8/47 (17%)
Query: 268 YIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTD 314
Y G+H PC G CI+ + + + C C GY+G++CEK +
Sbjct: 310 YCGSHHPCTNG--GTCINAEPD------QYRCTCPDGYSGRNCEKAE 348
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 1/73 (1%)
Query: 72 SDVRVCDESSCKYGGVCKEDGDGLK-CACQFQCHTNYIPVCGSNGDTYQNECFLRRAACK 130
S ++C C G C G C C QC + PVCGSNG TY N C L R AC
Sbjct: 26 SKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACL 85
Query: 131 HQKEITVIARGPC 143
+I V G C
Sbjct: 86 TGSKIQVDYDGHC 98
Score = 40.8 bits (94), Expect = 0.002
Identities = 17/55 (30%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 188 CVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTS 242
C+C C + PVC S+G +Y N C + +C+ +I + + GHC + S
Sbjct: 52 CLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVS 105
>gi|7669528 neuregulin 2 isoform 2 [Homo sapiens]
Length = 844
Score = 50.1 bits (118), Expect = 3e-06
Identities = 29/102 (28%), Positives = 50/102 (49%), Gaps = 12/102 (11%)
Query: 270 GNHMPCPENLNGYCIHGK-CEFIYSTQKASCRCESGYTGQHCEK---TDFSILYVVPSRQ 325
G+ C E YC++G C +I + SC+C GYTG C++ +FS + ++
Sbjct: 340 GHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSKAEELYQKR 399
Query: 326 KLTHVLIAAIIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQN 367
LT I + +A++V ++C+ C K + R+Q N
Sbjct: 400 VLT-------ITGICVALLVVGIVCVVAYC-KTKKQRKQMHN 433
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 49.3 bits (116), Expect = 6e-06
Identities = 71/292 (24%), Positives = 99/292 (33%), Gaps = 83/292 (28%)
Query: 53 DC-PGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQF-----QCHTN 106
DC PG G NC ++N E C+ + C GG CK+ G C C+ C TN
Sbjct: 740 DCDPGWSGT--NC-DINNNE-----CESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTN 791
Query: 107 YIPVCGSNG-----------DTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGE 155
I C SN Y+ C L + + A PC + E
Sbjct: 792 -INECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 156 E----------EGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCAS 205
E +G EV PC++ A C C C SG + C +
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRN----CET 906
Query: 206 D-GSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTS----LLGKKDDGLQYRPDVKD- 259
D NPC + G CTD +T+ L G + G D+ +
Sbjct: 907 DIDDCRPNPC---------------HNGGSCTDGINTAFCDCLPGFR--GTFCEEDINEC 949
Query: 260 ASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE 311
ASD N C + ++ Y +C C +G++G HCE
Sbjct: 950 ASDP-----CRNGANCTDCVDSY---------------TCTCPAGFSGIHCE 981
Score = 46.6 bits (109), Expect = 4e-05
Identities = 58/248 (23%), Positives = 86/248 (34%), Gaps = 35/248 (14%)
Query: 77 CDESSCKYGGVCKEDGDGLKCACQFQCHTNYI-PVCGSNGDTYQNECFLRRAACKHQKEI 135
C + C G C + K C C + Y P C + D EC L C+H
Sbjct: 376 CISNPCNEGSNCDTNPVNGKAICT--CPSGYTGPACSQDVD----ECSLGANPCEHA--- 426
Query: 136 TVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKC--GPCKYKAECDEDAENVGCVCNID 193
G C + GS + + +G ++C PC+ A C + C+C
Sbjct: 427 -----GKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPG 481
Query: 194 CSGYSFN---PVCASDGSSYNNPCF--VREASCIKQEQIDIRHLGHCTDTD-DTSLLGKK 247
G CAS +N C + E C + GH D D
Sbjct: 482 YEGVHCEVNTDECASSPCLHNGRCLDKINEFQC----ECPTGFTGHLCQYDVDECASTPC 537
Query: 248 DDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGY----CIHGKCEFIYSTQKASCRCES 303
+G + + + Y G H C +++ C +G C+ +T +C C
Sbjct: 538 KNGAKCLDGPNTYTCVCTEGYTGTH--CEVDIDECDPDPCHYGSCKDGVAT--FTCLCRP 593
Query: 304 GYTGQHCE 311
GYTG HCE
Sbjct: 594 GYTGHHCE 601
Score = 44.3 bits (103), Expect = 2e-04
Identities = 67/271 (24%), Positives = 97/271 (35%), Gaps = 63/271 (23%)
Query: 50 SGGDCPGG-KGKSINCSELNVRE---SDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHT 105
+GG C G G + C E S+V C+ + C +G C++ +G KC C
Sbjct: 689 NGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGA-CRDSLNGYKCDCD----- 742
Query: 106 NYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEG-SGAEVH 164
G+N D NEC E G D SG EG SG
Sbjct: 743 --PGWSGTNCDINNNEC-----------ESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQ 789
Query: 165 RKHSKC--GPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCI 222
++C PC + C +D C C + +G + V A S PC
Sbjct: 790 TNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPS---PC-------- 838
Query: 223 KQEQIDIRHLGHCTDTDD-TSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNG 281
R+ G C ++D S G Q Q +V I + P
Sbjct: 839 -------RNGGECRQSEDYESFSCVCPTGWQ---------GQTCEVDINECVLSP----- 877
Query: 282 YCIHG-KCEFIYSTQKASCRCESGYTGQHCE 311
C HG C+ + + C C++GY+G++CE
Sbjct: 878 -CRHGASCQNTHGGYR--CHCQAGYSGRNCE 905
Score = 42.7 bits (99), Expect = 5e-04
Identities = 57/263 (21%), Positives = 89/263 (33%), Gaps = 56/263 (21%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACK 130
E D+ C S C++G C+ G +C CQ G N +T ++C
Sbjct: 867 EVDINECVLSPCRHGASCQNTHGGYRCHCQ-------AGYSGRNCETDIDDC-------- 911
Query: 131 HQKEITVIARGPCYSDNGSGSGEGEE----------EGSGAEVHRKHSKCGPCKYKAECD 180
PC+ NG +G G+ E PC+ A C
Sbjct: 912 --------RPNPCH--NGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCT 961
Query: 181 EDAENVGCVCNIDCSGY---SFNPVCASDGSSYNNPCF--VREASCIKQEQIDIRHLGHC 235
+ ++ C C SG + P C C + +C+ + H
Sbjct: 962 DCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHD 1021
Query: 236 TDTDDTSLL---GKKDDGL-QYR---PDVKDASDQREDVYIGNHMPCPENLNGYCIHGKC 288
+ D+ G DG YR P + + V+ + PC NG GKC
Sbjct: 1022 VNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCK---NG----GKC 1074
Query: 289 EFIYSTQKASCRCESGYTGQHCE 311
++ + C C SG+TG +C+
Sbjct: 1075 WQTHTQYR--CECPSGWTGLYCD 1095
Score = 41.2 bits (95), Expect = 0.002
Identities = 59/259 (22%), Positives = 93/259 (35%), Gaps = 57/259 (22%)
Query: 55 PGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSN 114
PG G+ NC E ++ C ++CK GG C + + C C + Y C +
Sbjct: 247 PGFTGQ--NCEE------NIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQY---CTED 295
Query: 115 GDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKC--GP 172
D EC L AC++ G C++ +G + +G + C
Sbjct: 296 VD----ECQLMPNACQN--------GGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAA 343
Query: 173 CKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHL 232
C + A C + + C C +G +C + + +NPC E S ++ + +
Sbjct: 344 CFHGATCHDRVASFYCECPHGRTGL----LCHLNDACISNPC--NEGSNCDTNPVNGKAI 397
Query: 233 GHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIY 292
C G DV + S +G + PC GKC I
Sbjct: 398 CTCP---------SGYTGPACSQDVDECS-------LGAN-PCEH-------AGKC--IN 431
Query: 293 STQKASCRCESGYTGQHCE 311
+ C+C GYTG CE
Sbjct: 432 TLGSFECQCLQGYTGPRCE 450
Score = 40.8 bits (94), Expect = 0.002
Identities = 64/283 (22%), Positives = 96/283 (33%), Gaps = 78/283 (27%)
Query: 44 PGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQC 103
P G G D P S++C E+ + V V C++GG+C + G+ C CQ
Sbjct: 1086 PSGWTGLYCDVP-----SVSC-EVAAQRQGVDVA--RLCQHGGLCVDAGNTHHCRCQAGY 1137
Query: 104 HTNYI--------PVCGSNGDT-------YQNECFLRRAACKHQKEITVIARGPCYSDNG 148
+Y P NG T Y +C +EI PC NG
Sbjct: 1138 TGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPC--QNG 1195
Query: 149 SGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGS 208
G+ ++ P YK C + V C N+D +PV S
Sbjct: 1196 ---------GTCLDL--------PNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSP-- 1236
Query: 209 SYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVY 268
CF +C+ Q +G + T +G++ +G DV +
Sbjct: 1237 ----KCF-NNGTCVDQ-------VGGYSCTCPPGFVGERCEG-----DVNECLSN----- 1274
Query: 269 IGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE 311
PC C+ +F C C +G+TG+ CE
Sbjct: 1275 -----PCDARGTQNCVQRVNDF-------HCECRAGHTGRRCE 1305
Score = 37.7 bits (86), Expect = 0.017
Identities = 59/266 (22%), Positives = 91/266 (34%), Gaps = 44/266 (16%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHT-----NYIPVCGSNGDTYQNECFLR 125
+ DV CD C +GG C++ +C C Q +T N + C S+ +C+
Sbjct: 1019 QHDVNECDSQPCLHGGTCQDGCGSYRCTCP-QGYTGPNCQNLVHWCDSSPCKNGGKCW-- 1075
Query: 126 RAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKA---ECDED 182
+ +++ E G Y D S S E + G +V R G C C
Sbjct: 1076 QTHTQYRCECPSGWTG-LYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQ 1134
Query: 183 AENVGCVCNIDCSGYSFNP-----VCASDGSSYNNPCFVREASCIKQEQID------IRH 231
A G C S +P C Y+ C E+ID ++
Sbjct: 1135 AGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQN 1194
Query: 232 LGHCTDTDDTSLLG--KKDDGLQYRPDVKDASDQREDVYIG----NHMPCPENLNGYCIH 285
G C D +T + G+ +V D + + V N+ C + + GY
Sbjct: 1195 GGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGY--- 1251
Query: 286 GKCEFIYSTQKASCRCESGYTGQHCE 311
SC C G+ G+ CE
Sbjct: 1252 ------------SCTCPPGFVGERCE 1265
Score = 37.4 bits (85), Expect = 0.023
Identities = 58/267 (21%), Positives = 82/267 (30%), Gaps = 68/267 (25%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQ-----FQCHTNYIPVCGS----NG------ 115
E DV C + C+ C + +C C C N S NG
Sbjct: 450 EIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKI 509
Query: 116 DTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEE----------GSGAEVHR 165
+ +Q EC Q ++ A PC NG+ +G G+ EV
Sbjct: 510 NEFQCECPTGFTGHLCQYDVDECASTPC--KNGAKCLDGPNTYTCVCTEGYTGTHCEVDI 567
Query: 166 KHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQE 225
PC Y C + C+C GY+ + + + PC
Sbjct: 568 DECDPDPCHY-GSCKDGVATFTCLCR---PGYTGHHCETNINECSSQPC----------- 612
Query: 226 QIDIRHLGHCTDTDDTSLLG--KKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYC 283
RH G C D D+ L K G ++ D + D C + ++GY
Sbjct: 613 ----RHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCD-----SGTCLDKIDGY- 662
Query: 284 IHGKCEFIYSTQKASCRCESGYTGQHC 310
C CE GYTG C
Sbjct: 663 --------------ECACEPGYTGSMC 675
Score = 37.4 bits (85), Expect = 0.023
Identities = 56/251 (22%), Positives = 84/251 (33%), Gaps = 72/251 (28%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACK 130
E+++ C C++GG C++ + C C G N + ++C
Sbjct: 601 ETNINECSSQPCRHGGTCQDRDNAYLCFC-------LKGTTGPNCEINLDDC-------- 645
Query: 131 HQKEITVIARGPCYSDNGSGSGEGEE-------EGSGAEVHRKHSKCGPCKYKAECDEDA 183
A PC S +G E GS ++ PC C++
Sbjct: 646 --------ASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGI 697
Query: 184 ENVGCVCNIDCSGYSFNPVCASDGSSYN-NPCFVREASCIKQEQIDIRHLGHCTDTDDTS 242
C C GY +P C S+ + N NPC G C D S
Sbjct: 698 NGFTCRCP---EGY-HDPTCLSEVNECNSNPCV----------------HGACRD----S 733
Query: 243 LLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPEN--LNGYCIHGKCEFIYSTQKASCR 300
L G K D D + I N+ C N +NG G C+ + T C
Sbjct: 734 LNGYKCD--------CDPGWSGTNCDINNN-ECESNPCVNG----GTCKDM--TSGYVCT 778
Query: 301 CESGYTGQHCE 311
C G++G +C+
Sbjct: 779 CREGFSGPNCQ 789
Score = 36.6 bits (83), Expect = 0.038
Identities = 61/271 (22%), Positives = 87/271 (32%), Gaps = 71/271 (26%)
Query: 54 CPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGS 113
CP G I+C E++ C ESSC GG C + + C C G
Sbjct: 971 CPAGFS-GIHC------ENNTPDCTESSCFNGGTCVDGINSFTCLCP----------PGF 1013
Query: 114 NGDTYQ---NECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKC 170
G Q NEC + C H G C GS + +G C
Sbjct: 1014 TGSYCQHDVNECDSQ--PCLHG--------GTCQDGCGSYRCTCPQGYTGPNCQNLVHWC 1063
Query: 171 --GPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASC---IKQE 225
PCK +C + C C +G C V SC +++
Sbjct: 1064 DSSPCKNGGKCWQTHTQYRCECPSGWTGLY---------------CDVPSVSCEVAAQRQ 1108
Query: 226 QIDI----RHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNG 281
+D+ +H G C D +T + +D D+ N C + L G
Sbjct: 1109 GVDVARLCQHGGLCVDAGNTHHC--RCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGG 1166
Query: 282 YCIHGKCEFIYSTQKASCRCESGYTGQHCEK 312
Y SC+C +GY G +C +
Sbjct: 1167 Y---------------SCKCVAGYHGVNCSE 1182
Score = 35.8 bits (81), Expect = 0.066
Identities = 65/305 (21%), Positives = 91/305 (29%), Gaps = 71/305 (23%)
Query: 55 PGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSN 114
PG GKS C + + C + C GG C C C H P C +
Sbjct: 131 PGWSGKS--CQQADP-------CASNPCANGGQCLPFEASYICHCPPSFHG---PTCRQD 178
Query: 115 GDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGP-- 172
NEC + C+H G C+++ GS +G R + C P
Sbjct: 179 ----VNECGQKPGLCRHG--------GTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSP 226
Query: 173 ------CK------YKAECDEDAENVGCVCNID-CSGYSFNP--VCASDGSSYNNPCFVR 217
C+ ++ C C NID C G + C ++YN C
Sbjct: 227 CQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPE 286
Query: 218 EASCIKQEQIDIRHL--------GHCTDTDD--TSLLGKKDDGLQYRPDVKDASDQR--- 264
E +D L G C +T + G ++ D +
Sbjct: 287 WTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFH 346
Query: 265 ----EDVYIGNHMPCPENLNGYCIH-------------GKCEFIYSTQKASCRCESGYTG 307
D + CP G H C+ KA C C SGYTG
Sbjct: 347 GATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTG 406
Query: 308 QHCEK 312
C +
Sbjct: 407 PACSQ 411
>gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b
precursor [Homo sapiens]
Length = 1064
Score = 48.9 bits (115), Expect = 7e-06
Identities = 38/137 (27%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
C PV G++G Y N+C++ RA +T + S +EE S
Sbjct: 930 CPRENDPVHGADGKFYTNKCYMCRAVF-----LTEALERAKLQEKPSHVRASQEEDSPDS 984
Query: 163 VHRKHSKCGPCK-YKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASC 221
S+ CK Y+ +G +C D PVC DG +YNNPC + +
Sbjct: 985 FSSLDSEM--CKDYRV-----LPRIGYLCPKD-----LKPVCGDDGQTYNNPCMLCHENL 1032
Query: 222 IKQEQIDIRHLGHCTDT 238
I+Q IR G C ++
Sbjct: 1033 IRQTNTHIRSTGKCEES 1049
Score = 40.4 bits (93), Expect = 0.003
Identities = 39/143 (27%), Positives = 51/143 (35%), Gaps = 41/143 (28%)
Query: 89 KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNG 148
+ DGD F C Y VCG++G TY N C L K +I V + G C S N
Sbjct: 104 ERDGD-------FICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSN- 155
Query: 149 SGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGS 208
E R + G +GC D PV DG
Sbjct: 156 -------PEQDVCSAFRPFVRDG-------------RLGCTREND-------PVLGPDGK 188
Query: 209 SYNNPC------FVREASCIKQE 225
++ N C F++EA K+E
Sbjct: 189 THGNKCAMCAELFLKEAENAKRE 211
Score = 36.6 bits (83), Expect = 0.038
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 17/124 (13%)
Query: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
C PV G +G T+ N+C + +A + + E + D + +G G G G
Sbjct: 646 CTRENDPVRGPDGKTHGNKCAMCKAVFQKENEER---KRKEEEDQRNAAGHGSSGGGGGN 702
Query: 163 VHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCI 222
+C AE E +N C + +PV +DG SYNN C + +A
Sbjct: 703 TQ---DEC------AEYREQMKNGRLSCTRES-----DPVRDADGKSYNNQCTMCKAKLE 748
Query: 223 KQEQ 226
++ +
Sbjct: 749 REAE 752
Score = 33.5 bits (75), Expect = 0.33
Identities = 15/51 (29%), Positives = 22/51 (43%)
Query: 101 FQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGS 151
+ C + PVCG +G TY N C L Q + + G C + G+
Sbjct: 1004 YLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1054
Score = 32.3 bits (72), Expect = 0.73
Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 6/66 (9%)
Query: 194 CSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQY 253
C Y + VC +DG +Y+N C + + QI ++ G C ++ ++D +
Sbjct: 111 CPDY-YEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNP-----EQDVCSAF 164
Query: 254 RPDVKD 259
RP V+D
Sbjct: 165 RPFVRD 170
>gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
precursor [Homo sapiens]
Length = 1094
Score = 48.9 bits (115), Expect = 7e-06
Identities = 38/137 (27%), Positives = 56/137 (40%), Gaps = 18/137 (13%)
Query: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
C PV G++G Y N+C++ RA +T + S +EE S
Sbjct: 960 CPRENDPVHGADGKFYTNKCYMCRAVF-----LTEALERAKLQEKPSHVRASQEEDSPDS 1014
Query: 163 VHRKHSKCGPCK-YKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASC 221
S+ CK Y+ +G +C D PVC DG +YNNPC + +
Sbjct: 1015 FSSLDSEM--CKDYRV-----LPRIGYLCPKD-----LKPVCGDDGQTYNNPCMLCHENL 1062
Query: 222 IKQEQIDIRHLGHCTDT 238
I+Q IR G C ++
Sbjct: 1063 IRQTNTHIRSTGKCEES 1079
Score = 40.4 bits (93), Expect = 0.003
Identities = 39/143 (27%), Positives = 51/143 (35%), Gaps = 41/143 (28%)
Query: 89 KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNG 148
+ DGD F C Y VCG++G TY N C L K +I V + G C S N
Sbjct: 104 ERDGD-------FICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSN- 155
Query: 149 SGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGS 208
E R + G +GC D PV DG
Sbjct: 156 -------PEQDVCSAFRPFVRDG-------------RLGCTREND-------PVLGPDGK 188
Query: 209 SYNNPC------FVREASCIKQE 225
++ N C F++EA K+E
Sbjct: 189 THGNKCAMCAELFLKEAENAKRE 211
Score = 36.6 bits (83), Expect = 0.038
Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 17/124 (13%)
Query: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162
C PV G +G T+ N+C + +A + + E + D + +G G G G
Sbjct: 646 CTRENDPVRGPDGKTHGNKCAMCKAVFQKENEER---KRKEEEDQRNAAGHGSSGGGGGN 702
Query: 163 VHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCI 222
+C AE E +N C + +PV +DG SYNN C + +A
Sbjct: 703 TQ---DEC------AEYREQMKNGRLSCTRES-----DPVRDADGKSYNNQCTMCKAKLE 748
Query: 223 KQEQ 226
++ +
Sbjct: 749 REAE 752
Score = 33.5 bits (75), Expect = 0.33
Identities = 15/51 (29%), Positives = 22/51 (43%)
Query: 101 FQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGS 151
+ C + PVCG +G TY N C L Q + + G C + G+
Sbjct: 1034 YLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1084
Score = 32.3 bits (72), Expect = 0.73
Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 6/66 (9%)
Query: 194 CSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQY 253
C Y + VC +DG +Y+N C + + QI ++ G C ++ ++D +
Sbjct: 111 CPDY-YEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNP-----EQDVCSAF 164
Query: 254 RPDVKD 259
RP V+D
Sbjct: 165 RPFVRD 170
>gi|4503413 heparin-binding EGF-like growth factor [Homo sapiens]
Length = 208
Score = 48.5 bits (114), Expect = 1e-05
Identities = 22/79 (27%), Positives = 39/79 (49%), Gaps = 5/79 (6%)
Query: 274 PCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTDFSI---LYVVPSRQKLTHV 330
PC +CIHG+C+++ + SC C GY G+ C + LY L
Sbjct: 107 PCLRKYKDFCIHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTIL--A 164
Query: 331 LIAAIIGAVQIAIIVAIVM 349
++A ++ +V + +IV ++M
Sbjct: 165 VVAVVLSSVCLLVIVGLLM 183
>gi|7669530 neuregulin 2 isoform 3 [Homo sapiens]
Length = 858
Score = 48.1 bits (113), Expect = 1e-05
Identities = 30/109 (27%), Positives = 50/109 (45%), Gaps = 12/109 (11%)
Query: 270 GNHMPCPENLNGYCIHGK-CEFIYSTQKASCRCESGYTGQHC-EKTDFSILYVVPSRQKL 327
G+ C E YC++G C +I + SC+C +G+ GQ C EK + P ++ L
Sbjct: 340 GHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYMPDPKQKHL 399
Query: 328 THVLIAA---------IIGAVQIAIIVAIVMCITRKCPKNNRGRRQKQN 367
L A I + +A++V ++C+ C K + R+Q N
Sbjct: 400 GFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYC-KTKKQRKQMHN 447
>gi|4504619 insulin-like growth factor binding protein 7 [Homo
sapiens]
Length = 282
Score = 47.4 bits (111), Expect = 2e-05
Identities = 34/111 (30%), Positives = 46/111 (41%), Gaps = 22/111 (19%)
Query: 37 SRASNQPPGGGGGSGGDCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLK 96
+R +P GGGG G C G + C + R GVC
Sbjct: 64 ARGEGEPCGGGGAGRGYCAPG----MECVKSRKRRKGKAGAAAGGPGVSGVCV------- 112
Query: 97 CACQFQCHTNYIPVCGSNGDTYQNECFLR----RAACKHQKEITVIARGPC 143
C + Y PVCGS+G TY + C LR RA + +K IT +++G C
Sbjct: 113 ------CKSRY-PVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTC 156
Score = 30.4 bits (67), Expect = 2.8
Identities = 28/83 (33%), Positives = 34/83 (40%), Gaps = 10/83 (12%)
Query: 139 ARGPCYSDNGSGSGEGE-EEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGY 197
ARG G G+G G G RK K K A + CVC
Sbjct: 64 ARGEGEPCGGGGAGRGYCAPGMECVKSRKRRKG---KAGAAAGGPGVSGVCVCK------ 114
Query: 198 SFNPVCASDGSSYNNPCFVREAS 220
S PVC SDG++Y + C +R AS
Sbjct: 115 SRYPVCGSDGTTYPSGCQLRAAS 137
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 47.0 bits (110), Expect = 3e-05
Identities = 59/269 (21%), Positives = 92/269 (34%), Gaps = 53/269 (19%)
Query: 50 SGGDCPGGKGKSINCS-----ELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCH 104
+GG C + C+ E + E ++ C C+ GGVC + + C C Q
Sbjct: 232 NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT 291
Query: 105 TNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVH 164
+ C + D EC L+ AC++ G C + NG SG +
Sbjct: 292 GQF---CTEDVD----ECLLQPNACQN--------GGTCANRNGGYGCVCVNGWSGDDCS 336
Query: 165 RKHSKC--GPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCI 222
C C + C + + C+C +G +C D + +NPC
Sbjct: 337 ENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGL----LCHLDDACISNPC-------- 384
Query: 223 KQEQIDIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGY 282
H G DT+ L G+ D ++ ++ + N PC
Sbjct: 385 --------HKGALCDTN--PLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEH----- 429
Query: 283 CIHGKCEFIYSTQKASCRCESGYTGQHCE 311
GKC + + C C GY G CE
Sbjct: 430 --AGKC--VNTDGAFHCECLKGYAGPRCE 454
Score = 43.5 bits (101), Expect = 3e-04
Identities = 63/282 (22%), Positives = 87/282 (30%), Gaps = 67/282 (23%)
Query: 85 GGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCY 144
G C ED D +CA + C + + EC A + + +I PC
Sbjct: 409 GADCTEDVD--ECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDINECHSDPCQ 466
Query: 145 SDNGSGSGEGEE--------EGSGAEVHRKHSKCGPCKYKAECDEDAENVGC-------- 188
+D G +G E+ + PC +C + C
Sbjct: 467 NDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTG 526
Query: 189 -VCNIDCSGYSFNPV-----CASDGSSYNNPCFVREASCIKQEQIDIR-----HLGHCTD 237
VC ID S P C + Y C + +E ID H G C D
Sbjct: 527 PVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQD 586
Query: 238 TDDTSLLGKKDDGLQYRPDVKDA--SDQREDVYIG---NHMPCPENLNGY---------- 282
D+ P A SDQ ++ Y N C + +NGY
Sbjct: 587 GIDSYTC-------ICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG 639
Query: 283 --------------CIHGKCEFIYSTQKASCRCESGYTGQHC 310
CIHG C + + SC C G+TGQ C
Sbjct: 640 VNCEINFDDCASNPCIHGIC--MDGINRYSCVCSPGFTGQRC 679
Score = 41.6 bits (96), Expect = 0.001
Identities = 70/299 (23%), Positives = 101/299 (33%), Gaps = 83/299 (27%)
Query: 47 GGGSGGDCPGGKG-KSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQ----- 100
GG SG C G INC E D C + C+ GG C +G +C C+
Sbjct: 736 GGLSGYKCLCDAGWVGINC------EVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKG 789
Query: 101 FQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSG 160
+ C N I C SN C +Q G C+ D + +G
Sbjct: 790 YNCQVN-IDECASN-------------PCLNQ--------GTCFDDISGYTCHCVLPYTG 827
Query: 161 AEVHRKHSKCGP--CKYKAECDEDA--ENVGCVC---------NIDCSGYSFNP-----V 202
+ C P C+ A C E E+ C+C ID P +
Sbjct: 828 KNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGL 887
Query: 203 CASDGSSYNNPCFVREASCIKQEQID------IRHLGHCTDTDDT----SLLGKKDDGLQ 252
C + SY C + +E ID ++ G C D +T L G D Q
Sbjct: 888 CHNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCLPGFTGDKCQ 947
Query: 253 YRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCE 311
D+ + + N C + +N Y +C+C++G+ G HCE
Sbjct: 948 --TDMNECLSEP----CKNGGTCSDYVNSY---------------TCKCQAGFDGVHCE 985
Score = 37.4 bits (85), Expect = 0.023
Identities = 63/302 (20%), Positives = 104/302 (34%), Gaps = 85/302 (28%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACK 130
E+++ C ESSC GG C + + C C PV G G + C
Sbjct: 985 ENNINECTESSCFNGGTCVDGINSFSCLC---------PV-GFTG-----------SFCL 1023
Query: 131 HQKEITVIARGPCYSDNGSGSGEGEEEGS------GAEVHRKHSKC--GPCKYKAECDED 182
H EI + PC ++ G G S G + C PCK K C +
Sbjct: 1024 H--EINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQK 1081
Query: 183 AENVGCVC------------NIDCSGYS------------FNPVCASDGSSYNNPCFVRE 218
C+C N+ C + + VC + G+++ C +
Sbjct: 1082 KAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGY 1141
Query: 219 ASCIKQEQID------IRHLGHCTDTDD----TSLLGKKDDGLQYRPDV---KDASDQRE 265
+EQ+D +H C+D + G + +Y D + +
Sbjct: 1142 TGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGT 1201
Query: 266 DVYIGNH-----------MPCPENLNG-----YCIHGKCEFIYSTQKASCRCESGYTGQH 309
+ + NH + C EN++ +C++G + + SCRC G+ G+
Sbjct: 1202 CIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGG-QCMDRIGGYSCRCLPGFAGER 1260
Query: 310 CE 311
CE
Sbjct: 1261 CE 1262
Score = 35.8 bits (81), Expect = 0.066
Identities = 59/269 (21%), Positives = 94/269 (34%), Gaps = 67/269 (24%)
Query: 53 DCPGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYIPVCG 112
+CP G ++C E D+ C + C+ GG C + + C C + G
Sbjct: 898 ECPPGFS-GMDCEE------DIDDCLANPCQNGGSCMDGVNTFSCLC----------LPG 940
Query: 113 SNGDTYQ---NECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSK 169
GD Q NEC CK+ G C S + + + G ++
Sbjct: 941 FTGDKCQTDMNECLSE--PCKNG--------GTCSDYVNSYTCKCQAGFDGVHCENNINE 990
Query: 170 C--GPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQI 227
C C C + + C+C + +G SF ++ SS+ PC + E +C+
Sbjct: 991 CTESSCFNGGTCVDGINSFSCLCPVGFTG-SFCLHEINECSSH--PC-LNEGTCVDG--- 1043
Query: 228 DIRHLGHCTDTDDTSLLGKKDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGK 287
LG + GK L V + + PC G C+ K
Sbjct: 1044 ----LGTYRCSCPLGYTGKNCQTL---------------VNLCSRSPCKNK--GTCVQKK 1082
Query: 288 CEFIYSTQKASCRCESGYTGQHCEKTDFS 316
E + C C SG+ G +C+ + S
Sbjct: 1083 AE-------SQCLCPSGWAGAYCDVPNVS 1104
Score = 35.0 bits (79), Expect = 0.11
Identities = 19/50 (38%), Positives = 23/50 (46%), Gaps = 13/50 (26%)
Query: 275 CPENLNG-YCIH------------GKCEFIYSTQKASCRCESGYTGQHCE 311
CPE G YC H G C KA+CRC SG+TG+ C+
Sbjct: 53 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 102
Score = 33.1 bits (74), Expect = 0.43
Identities = 53/245 (21%), Positives = 81/245 (33%), Gaps = 61/245 (24%)
Query: 71 ESDVRVCDESSCKYGGVCKEDGDGLKCACQFQCHTNYI-PVCGSNGDTYQNECFLRRAAC 129
E ++ CD C +G C++ D C C + Y+ +C D + L C
Sbjct: 568 EENIDNCDPDPCHHGQ-CQDGIDSYTCIC----NPGYMGAICSDQIDECYSSPCLNDGRC 622
Query: 130 KHQKEITVIARGPCYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCV 189
I ++ C G+ G E++ PC + C + CV
Sbjct: 623 -----IDLVNGYQCNCQPGTS-------GVNCEINFDDCASNPCIHGI-CMDGINRYSCV 669
Query: 190 CNIDCSGYSFN---PVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGK 246
C+ +G N CAS NPC + A+CI
Sbjct: 670 CSPGFTGQRCNIDIDECAS------NPCR-KGATCI------------------------ 698
Query: 247 KDDGLQYRPDVKDASDQREDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYT 306
+G+ + Y E L+ CIHG C S K C C++G+
Sbjct: 699 --NGVNGFRCICPEGPHHPSCY----SQVNECLSNPCIHGNCTGGLSGYK--CLCDAGWV 750
Query: 307 GQHCE 311
G +CE
Sbjct: 751 GINCE 755
Score = 31.2 bits (69), Expect = 1.6
Identities = 15/50 (30%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 265 EDVYIGNHMPCPENLNGYCIHGKCEFIYSTQKASCRCESGYTGQHCEKTD 314
ED PC ++ C++G + S C C+ G+TG+ C+ TD
Sbjct: 99 EDCQYSTSHPC--FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD 146
Score = 30.0 bits (66), Expect = 3.6
Identities = 18/53 (33%), Positives = 26/53 (49%), Gaps = 9/53 (16%)
Query: 48 GGSGGDC-PGGKGKSINCSELNVRESDVRVCDESSCKYGGVCKEDGDGLKCAC 99
GG +C PG +G +NC E +V C C+ GG C + + KC+C
Sbjct: 1169 GGYRCECVPGYQG--VNC------EYEVDECQNQPCQNGGTCIDLVNHFKCSC 1213
Score = 29.3 bits (64), Expect = 6.1
Identities = 52/261 (19%), Positives = 83/261 (31%), Gaps = 61/261 (23%)
Query: 71 ESDVRVCDESSCKYGGVC---KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRA 127
E+ V VC + C GG C DG C C G +G Q+ C +
Sbjct: 1302 ETFVDVCPQMPCLNGGTCAVASNMPDGFICRCP----------PGFSGARCQSSC--GQV 1349
Query: 128 ACKHQKEITVIARGP---CYSDNGSGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAE 184
C+ ++ A GP C S SG PC++ C +
Sbjct: 1350 KCRKGEQCVHTASGPRCFCPSPRDCESG---------------CASSPCQHGGSCHPQRQ 1394
Query: 185 NVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLL 244
C C+ P S Y P A+C+ Q +C D +
Sbjct: 1395 PPYYSC--QCA----PPFSGSRCELYTAPPSTPPATCLSQ---------YCADKARDGVC 1439
Query: 245 GKKDDGLQYRPDVKDASDQREDVY--IGNHMPCPENLNGYC-----------IHGKCEFI 291
+ + + D D S E+ + + +PC + +N C + +C+
Sbjct: 1440 DEACNSHACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQGN 1499
Query: 292 YSTQKASCRCESGYTGQHCEK 312
T K C + HC++
Sbjct: 1500 SKTCKYDKYCADHFKDNHCDQ 1520
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.437
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,687,353
Number of Sequences: 37866
Number of extensions: 969532
Number of successful extensions: 7422
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 140
Number of HSP's that attempted gapping in prelim test: 6005
Number of HSP's gapped (non-prelim): 1241
length of query: 380
length of database: 18,247,518
effective HSP length: 104
effective length of query: 276
effective length of database: 14,309,454
effective search space: 3949409304
effective search space used: 3949409304
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.