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Search of human proteins with 122937309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
(713 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 1460 0.0
gi|51317373 netrin-G1 ligand [Homo sapiens] 810 0.0
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 734 0.0
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 184 3e-46
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 180 4e-45
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 168 1e-41
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 165 2e-40
gi|27363458 leucine rich repeat and fibronectin type III domain ... 162 1e-39
gi|55741571 leucine rich repeat and fibronectin type III domain ... 152 1e-36
gi|31542244 leucine rich repeat and fibronectin type III domain ... 151 2e-36
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 141 2e-33
gi|88702793 slit-like 2 [Homo sapiens] 136 8e-32
gi|13375646 leucine rich repeat and fibronectin type III domain ... 135 1e-31
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 134 2e-31
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 134 2e-31
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 134 2e-31
gi|225579152 insulin-like growth factor binding protein, acid la... 134 4e-31
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 134 4e-31
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 133 5e-31
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 133 5e-31
gi|109150416 peroxidasin [Homo sapiens] 133 7e-31
gi|198041768 synleurin [Homo sapiens] 132 9e-31
gi|153251229 chondroadherin precursor [Homo sapiens] 132 9e-31
gi|149773484 leucine rich repeat and fibronectin type III domain... 131 2e-30
gi|126517478 peroxidasin homolog-like [Homo sapiens] 130 3e-30
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 130 3e-30
gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens] 130 4e-30
gi|4826772 insulin-like growth factor binding protein, acid labi... 129 7e-30
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 129 1e-29
gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens] 129 1e-29
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 1460 bits (3779), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVA 60
MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVA
Sbjct: 1 MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVA 60
Query: 61 CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120
CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN
Sbjct: 61 CSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKN 120
Query: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180
LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR
Sbjct: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180
Query: 181 VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNR 240
VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNR
Sbjct: 181 VPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNR 240
Query: 241 LDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPL 300
LDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPL
Sbjct: 241 LDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPL 300
Query: 301 HRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFT 360
HRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFT
Sbjct: 301 HRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFT 360
Query: 361 CYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGT 420
CYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGT
Sbjct: 361 CYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGT 420
Query: 421 LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGG 480
LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGG
Sbjct: 421 LNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGGSGGVGGG 480
Query: 481 SGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTA 540
SGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTA
Sbjct: 481 SGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTA 540
Query: 541 PAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLR 600
PAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLR
Sbjct: 541 PAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLR 600
Query: 601 KQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHL 660
KQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHL
Sbjct: 601 KQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHL 660
Query: 661 NHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI 713
NHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI
Sbjct: 661 NHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI 713
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 810 bits (2091), Expect = 0.0
Identities = 406/660 (61%), Positives = 485/660 (73%), Gaps = 63/660 (9%)
Query: 54 ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
A +CP CSCSNQ S+VIC R++L EVP I NTR LNL EN IQ+I+ ++FKHLRHLE
Sbjct: 44 AQTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLE 103
Query: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESI 173
ILQLS+N +R IE+GAFNGL +LNTLELFDNRLTT+P AF YLSKL+ELWLRNNPIESI
Sbjct: 104 ILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESI 163
Query: 174 PSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEE 233
PSYAFNR+PSLRRLDLGELKRL YISE AFEGL NLRYLNL MCNL++IPNLT L++L+E
Sbjct: 164 PSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDE 223
Query: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
L+LSGN L IRPGSFQGL L+KLW++ +Q+ IERNAFD+L+SL E+NL+HNNL LP
Sbjct: 224 LDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLP 283
Query: 294 HDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGE 353
HDLFTPLH LER+HL+HNPW+CNCD+LWLSWW+K+ PSNT CCARC+ P LKGRYIGE
Sbjct: 284 HDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGE 343
Query: 354 LDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGSYRVRI 413
LDQ++FTCYAPVIVEPP DLNVTEGMAAELKCR TS+TSV+W+TPNGT+MTHG+Y+VRI
Sbjct: 344 LDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRI 403
Query: 414 SVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGGGPGG 473
+VL DGTLNFTNVTVQDTG YTCMV+NS GNTTASATLNV+A
Sbjct: 404 AVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTP------------- 450
Query: 474 SGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGP 533
++YF+TVTVET+E E T GPT W
Sbjct: 451 ----------FSYFSTVTVETMEPSQDEAR-----TTDNNVGPTPVVDW----------E 485
Query: 534 ASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAITFMAAVML 593
++ TT+ P+S+R TEK FT+P+TD+ + + +D+VMKTTKIIIGCFVAIT MAAVML
Sbjct: 486 TTNVTTSLTPQSTRSTEKTFTIPVTDI-NSGIPGIDEVMKTTKIIIGCFVAITLMAAVML 544
Query: 594 VAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALP 653
V FYK+RKQH HH PTRTVEIINV+DE+ G +SHL +P
Sbjct: 545 VIFYKMRKQHHRQNHHAPTRTVEIINVDDEIT----------------GDTPMESHLPMP 588
Query: 654 ALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI 713
A+E +HLNH++ + F + N +S+HEPLL + SK+NVQETQI
Sbjct: 589 AIEHEHLNHYNSYKSPFNHTTTVNTINS--------IHSSVHEPLLIRMNSKDNVQETQI 640
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 734 bits (1895), Expect = 0.0
Identities = 381/672 (56%), Positives = 475/672 (70%), Gaps = 52/672 (7%)
Query: 42 AVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVI 101
A+ +AA G +CP CSCSNQ S+V+CTRR L+EVP IP NTRYLNL EN IQ+I
Sbjct: 34 AIAAAASAGPQ---NCPSVCSCSNQFSKVVCTRRGLSEVPQGIPSNTRYLNLMENNIQMI 90
Query: 102 RTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLR 161
+ DTF+HL HLE+LQL +N +R+IEVGAFNGL SLNTLELFDN LT +P+ AFEYLSKLR
Sbjct: 91 QADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKLR 150
Query: 162 ELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKD 221
ELWLRNNPIESIPSYAFNRVPSL RLDLGELK+LEYISE AFEGL NL+YLNLGMCN+KD
Sbjct: 151 ELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCNIKD 210
Query: 222 IPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEE 281
+PNLT LV LEELE+SGN IRPGSF GL+SL+KLW+M++QV+ IERNAFD L SL E
Sbjct: 211 MPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVE 270
Query: 282 LNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCH 341
LNL+HNNL SLPHDLFTPL L +HL+HNPW+C+CD+LWL+WWL+E +P+N+TCC RCH
Sbjct: 271 LNLAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWLAWWLREYIPTNSTCCGRCH 330
Query: 342 APAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWLTPNG 401
AP ++GRY+ E+DQ+ F C AP I++ P DLN++EG AELKCRT M+SV WL PNG
Sbjct: 331 APMHMRGRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRT-PPMSSVKWLLPNG 389
Query: 402 TLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAA 461
T+++H S RISVL+DGTLNF++V + DTG YTCMVTN AGN+ ASA LNVS +
Sbjct: 390 TVLSHASRHPRISVLNDGTLNFSHVLLSDTGVYTCMVTNVAGNSNASAYLNVSTAEL--- 446
Query: 462 GGTGSGGGGPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRGTEKEPPGPTTDGV 521
+ Y++FTTVTVET E P + T K P PTT
Sbjct: 447 ------------------NTSNYSFFTTVTVETTEISPEDT------TRKYKPVPTT--- 479
Query: 522 WGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKIIIGC 581
PA +++T +++R K VP TD T+ LD+VMKTTKIIIGC
Sbjct: 480 ------STGYQPAYTTSTTVLIQTTR-VPKQVAVPATDTTDKMQTSLDEVMKTTKIIIGC 532
Query: 582 FVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASG 641
FVA+T +AA ML+ FYKLRK+HQ RTVEII V++++PAA+ +AAA A+
Sbjct: 533 FVAVTLLAAAMLIVFYKLRKRHQQRSTVTAARTVEIIQVDEDIPAAT-----SAAATAAP 587
Query: 642 GGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFK 701
GV G+ + LP + DH+N++ Y A AH++ N G P + +I EP + +
Sbjct: 588 SGVSGEGAVVLPTI-HDHINYNTY-KPAHGAHWTENSLGNSL----HPTVTTISEPYIIQ 641
Query: 702 SGSKENVQETQI 713
+ +K+ VQETQI
Sbjct: 642 THTKDKVQETQI 653
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 184 bits (466), Expect = 3e-46
Identities = 153/491 (31%), Positives = 216/491 (43%), Gaps = 90/491 (18%)
Query: 51 SPPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLR 110
S AT CP C CS Q V+C R+ VP IP TR L+L +N I+ + D F
Sbjct: 36 SGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFP 95
Query: 111 HLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPI 170
HLE L+L++N+V +E GAFN L +L TL L NRL +P F LS L +L + N I
Sbjct: 96 HLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKI 155
Query: 171 ESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP------- 223
+ Y F + +L+ L++G+ L YIS AF GL +L L L CNL IP
Sbjct: 156 VILLDYMFQDLYNLKSLEVGD-NDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHL 214
Query: 224 -----------NLTA--------LVRLEELELS-GNRLDLIRPGSFQG------------ 251
N+ A L RL+ LE+S LD + P G
Sbjct: 215 HGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCN 274
Query: 252 -----------LTSLRKLWLMHAQVATIERNAFDDLKSLEE------------------- 281
L LR L L + ++TIE + +L L+E
Sbjct: 275 LTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL 334
Query: 282 -----LNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL---SWWLKETVPSN 333
LN+S N L +L +F + LE + L+ NP C+C +LW+ W L
Sbjct: 335 NYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQP 394
Query: 334 TTCCARCHAPAGLKGRYIGE----LDQSHFTC-YAPVIVEPPTDLNVTEGMAAELKCRT- 387
T C P ++G+ + L ++FTC A + + V EG + CR
Sbjct: 395 T-----CATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRAD 449
Query: 388 GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTA 447
G ++ WL+P L++ S R++V DGTL VQD G Y C+ N+ GN +
Sbjct: 450 GDPPPAILWLSPRKHLVSAKS-NGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSM 508
Query: 448 SATLNVSAVDP 458
A L+V + P
Sbjct: 509 PAHLHVRSYSP 519
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 180 bits (457), Expect = 4e-45
Identities = 143/477 (29%), Positives = 212/477 (44%), Gaps = 84/477 (17%)
Query: 57 CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQ 116
CP C CS Q V C RR L +P IP+ T+ L+L +N ++ + + F LE +
Sbjct: 28 CPARCECSAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLLEEID 87
Query: 117 LSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSY 176
LS N++ +E GAFN L +L +L L NRL VP F LS L +L + N I + Y
Sbjct: 88 LSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVILLDY 147
Query: 177 AFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP-----NLTALVRL 231
F + +L+ L++G+ L YIS AF GL++L L L CNL +P +L +L+ L
Sbjct: 148 MFQDLHNLKSLEVGD-NDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSLISL 206
Query: 232 EELELSGNR----------------------LDLIRPGS--------------------- 248
L+ N LD++ S
Sbjct: 207 HLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLSTVPF 266
Query: 249 --FQGLTSLRKLWLMHAQVATIERNAFDDLKSLEE------------------------L 282
F+ L L L L + ++TIE F DL L+E L
Sbjct: 267 LAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVL 326
Query: 283 NLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHA 342
N+S N L +L ++F+ LE + +N+NP C+C +LW+ ++ C
Sbjct: 327 NVSQNLLETLEENVFSSPRALEVLSINNNPLACDCRLLWI--LQRQPTLQFGGQQPMCAG 384
Query: 343 PAGLKGRYIGELDQS----HFTCYAPVIVEPPTD-LNVTEGMAAELKCRT-GTSMTSVNW 396
P ++ R + + +FTC P I E L V EG +L+C G ++W
Sbjct: 385 PDTIRERSFKDFHSTALSFYFTCKKPKIREKKLQHLLVDEGQTVQLECSADGDPQPVISW 444
Query: 397 LTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+TP +T S R +VL DGTL QD+G Y C+ +N+AGN T +A+L V
Sbjct: 445 VTPRRRFITTKS-NGRATVLGDGTLEIRFAQDQDSGMYVCIASNAAGNDTFTASLTV 500
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 168 bits (426), Expect = 1e-41
Identities = 143/482 (29%), Positives = 204/482 (42%), Gaps = 84/482 (17%)
Query: 52 PPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYL-------------------- 91
PPA CP C C+ Q V CTRR L VP IP TR L
Sbjct: 20 PPAGGCPARCECTVQTRAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPA 79
Query: 92 ----NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLT 147
+L EN I + F +L L +L+L N ++ I G F L +L L+L +N+L
Sbjct: 80 LEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLV 139
Query: 148 TVPTQAFEYLSKLRELW------------------------------------------- 164
+ F+ L LR L
Sbjct: 140 ILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRS 199
Query: 165 -----LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNL 219
LR+ I S+ F R+P L L++ LE ++ + GL NL L++ N+
Sbjct: 200 LGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNI 258
Query: 220 KDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLK 277
+P L L L LS N + + GSF+ L LR+L L A +A +E AF L+
Sbjct: 259 TAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLR 318
Query: 278 SLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCC 337
+ LNLS+N L +L F ++ LE + ++ NP C+C +LW+ ++T+ +
Sbjct: 319 QIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIV-QRRKTLNFDGRLP 377
Query: 338 ARCHAPAGLKGRYIGELDQS----HFTCYAPVIVEPPTD-LNVTEGMAAELKCRT-GTSM 391
A C PA ++G + L S +F C P I E + T G CR G
Sbjct: 378 A-CATPAEVRGDALRNLPDSVLFEYFVCRKPKIRERRLQRVTATAGEDVRFLCRAEGEPA 436
Query: 392 TSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATL 451
+V W+TP +T S R VL GTL + QD+G YTC+ +N+ GN T ATL
Sbjct: 437 PTVAWVTPQHRPVTATS-AGRARVLPGGTLEIQDARPQDSGTYTCVASNAGGNDTYFATL 495
Query: 452 NV 453
V
Sbjct: 496 TV 497
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 165 bits (417), Expect = 2e-40
Identities = 155/528 (29%), Positives = 222/528 (42%), Gaps = 112/528 (21%)
Query: 10 PPLPPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR 69
PP PP LLFL L P G+GG SCP C C++Q
Sbjct: 12 PPWPP---------LLFLLLL--PGGSGG-----------------SCPAVCDCTSQPQA 43
Query: 70 VICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGA 129
V+C R L VP +P++T L+L N + ++ L L+ L LS N + +E GA
Sbjct: 44 VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGA 103
Query: 130 FNGLPSLNTL------------------------------------------------EL 141
F+GL SL TL E+
Sbjct: 104 FHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEV 163
Query: 142 FDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSL-----RRLD-------- 188
DN L V AF L+KL L L + ++P A R+P+L R LD
Sbjct: 164 GDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGA 223
Query: 189 ---LGELKRLEYISEAAFEGL-------VNLRYLNLGMCNLKDIP--NLTALVRLEELEL 236
LG+LK LE + E L +NL L + CNL +P L L L L+L
Sbjct: 224 LRGLGQLKELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDL 283
Query: 237 SGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDL 296
S N + I L L++L L A + +I +AF L + L+++ N L +L
Sbjct: 284 SQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETA 343
Query: 297 FTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGE--- 353
F +L + L+ NP C+C +LWL L+ + + A C P ++G+ + E
Sbjct: 344 FPSPDKLVTLRLSGNPLTCDCRLLWL-LRLRRHLDFGMSPPA-CAGPHHVQGKSLKEFSD 401
Query: 354 -LDQSHFTCYAPVIVEP-PTDLNVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYR 410
L HFTC +I + P + EG A C G +V+W+ P+G +
Sbjct: 402 ILPPGHFTCKPALIRKSGPRWVIAEEGGHAVFSCSGDGDPAPTVSWMRPHGAWLGRAG-- 459
Query: 411 VRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDP 458
R+ VL DGTL +V ++D G Y C+V+N AGN + L V V+P
Sbjct: 460 -RVRVLEDGTLEIRSVQLRDRGAYVCVVSNVAGNDSLRTWLEVIQVEP 506
>gi|27363458 leucine rich repeat and fibronectin type III domain
containing 4 [Homo sapiens]
Length = 635
Score = 162 bits (410), Expect = 1e-39
Identities = 143/482 (29%), Positives = 209/482 (43%), Gaps = 71/482 (14%)
Query: 54 ATSCPVACSCSN--QASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
A +CP+ C C N ++ +C R L VP ++ T L L +N IQ + F+++
Sbjct: 14 AAACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQALGPPDFRNMTG 73
Query: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171
L L LS+N + +I AF L SL +L L NRL + T + L+ L L N +
Sbjct: 74 LVDLTLSRNAITRIGARAFGDLESLRSLHLDGNRLVELGTGSLRGPVNLQHLILSGNQLG 133
Query: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP--NLTALV 229
I AF+ + L +L L+L NL+ +P + A+
Sbjct: 134 RIAPGAFD------------------------DFLESLEDLDLSYNNLRQVPWAGIGAMP 169
Query: 230 RLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL 289
L L L N +D + PG+F L L +L L ++AT+ A D L S +
Sbjct: 170 ALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATL---APDPLFS------RGRDA 220
Query: 290 MSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGR 349
+ P L + + NP HCNC++LWL + P + CA +P GL GR
Sbjct: 221 EASPAPLV--------LSFSGNPLHCNCELLWLR---RLARPDDLETCA---SPPGLAGR 266
Query: 350 YIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGS 408
Y + + F+C P+I L V EG A L+CR G +++W+ P+ L+ + S
Sbjct: 267 YFWAVPEGEFSCEPPLIARHTQRLWVLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSS 326
Query: 409 YRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGG 468
R +GTL D G YTC+ TN AG TA L V A + GG S
Sbjct: 327 ---RARAFPNGTLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLA---LPHGGNSSAE 380
Query: 469 GGPGGSGGVGGGSGGYTYFTTVTVE-TLETQPGEEALQPRGTEKEPPGPTTDGVWGGGRP 527
GG G + + T E TLE++P + + T G + WG GRP
Sbjct: 381 GGRPGPSDIAASAR-----TAAEGEGTLESEPAVQVTEVTATS----GLVS---WGPGRP 428
Query: 528 GD 529
D
Sbjct: 429 AD 430
>gi|55741571 leucine rich repeat and fibronectin type III domain
containing 2 [Homo sapiens]
Length = 789
Score = 152 bits (384), Expect = 1e-36
Identities = 128/452 (28%), Positives = 185/452 (40%), Gaps = 91/452 (20%)
Query: 56 SCPVACSCSNQASRV--ICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
+CP C C N + + +C + L VP I T L L N I I F ++ L
Sbjct: 20 ACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHISRQDFANMTGLV 79
Query: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESI 173
L LS+N + I+ +F L SL +L L NRL ++ L L+ L + NN + I
Sbjct: 80 DLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGI 139
Query: 174 PSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP--NLTALVRL 231
AF + L+ L L+L NL +P ++ +V L
Sbjct: 140 ADEAFE------------------------DFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
Query: 232 EELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMS 291
+L L N LD I G+F DL+ L L+L+ N L
Sbjct: 176 HQLSLDHNLLDHIAEGTFA------------------------DLQKLARLDLTSNRLQK 211
Query: 292 LPHD-----------LFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARC 340
LP D TP NP HCNC++LWL ++ C
Sbjct: 212 LPPDPIFARSQASALTATPFAPPLSFSFGGNPLHCNCELLWLRRLERD------DDLETC 265
Query: 341 HAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTP 399
+P GLKGRY + + F C P+I + L V EG AA LKC+ G ++W+ P
Sbjct: 266 GSPGGLKGRYFWHVREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAP 325
Query: 400 NGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAV--- 456
+ L+ + S R +V +GTL+ T QD+G +TC+ N+AG TA +++ +
Sbjct: 326 DDRLVGNSS---RTAVYDNGTLDIFITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHL 382
Query: 457 ---------------DPVAAGGTGSGGGGPGG 473
D + T GGGG GG
Sbjct: 383 SNSTSRTAPPKSRLSDITGSSKTSRGGGGSGG 414
Score = 149 bits (375), Expect = 1e-35
Identities = 115/371 (30%), Positives = 168/371 (45%), Gaps = 48/371 (12%)
Query: 139 LELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYI 198
L L N + + Q F ++ L +L L N I I ++F + SLR L L + RL +
Sbjct: 57 LRLGGNFIIHISRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHL-DSNRLPSL 115
Query: 199 SEAAFEGLVNLRYL---NLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSL 255
E GLVNL++L N + + D L+ LE+L+LS N L + S + + +L
Sbjct: 116 GEDTLRGLVNLQHLIVNNNQLGGIADEAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNL 175
Query: 256 RKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLF-----------TPLHRLE 304
+L L H + I F DL+ L L+L+ N L LP D TP
Sbjct: 176 HQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASALTATPFAPPL 235
Query: 305 RVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAP 364
NP HCNC++LWL ++ C +P GLKGRY + + F C P
Sbjct: 236 SFSFGGNPLHCNCELLWLRRLERDDDLET------CGSPGGLKGRYFWHVREEEFVCEPP 289
Query: 365 VIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNF 423
+I + L V EG AA LKC+ G ++W+ P+ L+ + S R +V +GTL+
Sbjct: 290 LITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSS---RTAVYDNGTLDI 346
Query: 424 TNVTVQDTGQYTCMVTNSAGNTTA-----------------------SATLNVSAVDPVA 460
T QD+G +TC+ N+AG TA S +++ +
Sbjct: 347 FITTSQDSGAFTCIAANAAGEATAMVEVSIVQLPHLSNSTSRTAPPKSRLSDITGSSKTS 406
Query: 461 AGGTGSGGGGP 471
GG GSGGG P
Sbjct: 407 RGGGGSGGGEP 417
>gi|31542244 leucine rich repeat and fibronectin type III domain
containing 5 [Homo sapiens]
Length = 719
Score = 151 bits (382), Expect = 2e-36
Identities = 120/405 (29%), Positives = 180/405 (44%), Gaps = 52/405 (12%)
Query: 54 ATSCPVACSCSNQASRV--ICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
A CP C C + + +C ++ L VP +I T L L +N + I+ F ++
Sbjct: 17 AQICPKRCVCQILSPNLATLCAKKGLLFVPPNIDRRTVELRLADNFVTNIKRKDFANMTS 76
Query: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171
L L LS+N + I AF L +L L L NRLT + F LS L L L NN +
Sbjct: 77 LVDLTLSRNTISFITPHAFADLRNLRALHLNSNRLTKITNDMFSGLSNLHHLILNNNQLT 136
Query: 172 SIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIP--NLTALV 229
I S AF+ V +L LDL LE I A E +V+L L+L + +IP + L
Sbjct: 137 LISSTAFDDVFALEELDL-SYNNLETIPWDAVEKMVSLHTLSLDHNMIDNIPKGTFSHLH 195
Query: 230 RLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNL 289
++ L+++ N+L + P AQV A + S LS
Sbjct: 196 KMTRLDVTSNKLQKLPPDPL----------FQRAQVL-----ATSGIISPSTFALSFGG- 239
Query: 290 MSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGR 349
NP HCNC++LWL +E C +P L GR
Sbjct: 240 ---------------------NPLHCNCELLWLRRLSRE------DDLETCASPPLLTGR 272
Query: 350 YIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGS 408
Y + + F C P+I ++ V EG A L+C+ G +++W++P G L+++ +
Sbjct: 273 YFWSIPEEEFLCEPPLITRHTHEMRVLEGQRATLRCKARGDPEPAIHWISPEGKLISNAT 332
Query: 409 YRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
R V +GTL+ TV+DTG +TC+ +N AG T L++
Sbjct: 333 ---RSLVYDNGTLDILITTVKDTGAFTCIASNPAGEATQIVDLHI 374
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 141 bits (355), Expect = 2e-33
Identities = 125/390 (32%), Positives = 184/390 (47%), Gaps = 32/390 (8%)
Query: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
++L L+ N I+++ TF+ L L L++ +N + K++ GAF GL ++ LEL N LT
Sbjct: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Query: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
V L L++L++ N IE I A+ L LDL +L + E+AF GL
Sbjct: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDL-SYNQLTRLDESAFVGLSL 336
Query: 209 LRYLNLGMCNLKDIPN--LTALVRLEELELSGNRLD-LIRPGS--FQGLTSLRKLWLMHA 263
L LNLG + I + L L+ L+L N + I S F GLTSL KL L
Sbjct: 337 LERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGN 396
Query: 264 QVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLS 323
Q+ +I + AF L+SLE L+L++N +MS+ + F+ H L+ + LN + C+C + WL
Sbjct: 397 QIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTH-LKELILNTSSLLCDCHLKWLL 455
Query: 324 WWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMA 380
WL + ++ + C P L G+ I +D F C P I P + GM
Sbjct: 456 QWLVDNNFQHSVNVS-CAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPETIIALRGMN 514
Query: 381 AELKC---RTGTSMTSVNWLTPNGTL------------MTHGSYRVRISVLHDGTLNFTN 425
L C + S S W + L G S+LH +NFT
Sbjct: 515 VTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILHLFNVNFT- 573
Query: 426 VTVQDTGQYTCMVTNSAG-NTTASATLNVS 454
D G+Y C+VTN G N + A L V+
Sbjct: 574 ----DEGKYQCIVTNHFGSNYSQKAKLTVN 599
Score = 80.1 bits (196), Expect = 7e-15
Identities = 76/275 (27%), Positives = 125/275 (45%), Gaps = 23/275 (8%)
Query: 46 AAGGGSPPATSCPVACSCSNQASRVICTRRDLAE-----VPASIPVNTRYLNLQENGIQV 100
AAG G CP CSC + + C+RR L + +P +T L+ N
Sbjct: 37 AAGAGL-----CPAPCSC--RIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHN---- 85
Query: 101 IRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNT--LELFDNRLTTVPTQAFEYLS 158
R + + LQ K ++ + G P+ N L L N + + QA ++
Sbjct: 86 -RLSNWNISLESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYP 144
Query: 159 KLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-LRYLNLGMC 217
L L L +N I I + +F R+ L+ L+L R+ + F+ L + L + L
Sbjct: 145 ALESLDLSSNIISEIKTSSFPRM-QLKYLNLSN-NRITTLEAGCFDNLSSSLLVVKLNRN 202
Query: 218 NLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDL 276
+ IP + L L+ LEL NR+ ++ +FQGL SLR L + ++ ++ AF L
Sbjct: 203 RMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGL 262
Query: 277 KSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
++EEL L HNNL + L L++++++ N
Sbjct: 263 NNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQN 297
Score = 50.4 bits (119), Expect = 6e-06
Identities = 28/91 (30%), Positives = 42/91 (46%), Gaps = 1/91 (1%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P ++ P DL + G A L+C G ++W GT R + D
Sbjct: 602 PSFLKTPMDLTIRTGAMARLECAAEGHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFF 661
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
NV ++D G Y+CM N+AG +A+A+L V
Sbjct: 662 IANVKIEDMGIYSCMAQNTAGGLSANASLTV 692
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/91 (28%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMTS-VNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P + P D VT G A L+C G S +NW +G L+ + + + L
Sbjct: 696 PSFIRPLEDKTVTRGETAVLQCIAGGSPAPRLNWTKDDGPLLVTERHFFAAA---NQLLI 752
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+ ++D G+YTC+++N+ G LNV
Sbjct: 753 IVDAGLEDAGKYTCIMSNTLGTERGHIYLNV 783
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 136 bits (342), Expect = 8e-32
Identities = 116/372 (31%), Positives = 174/372 (46%), Gaps = 52/372 (13%)
Query: 52 PPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRH 111
P CP C CS Q V CT R VP +P +T L + ENGI ++ +F L
Sbjct: 19 PGVQGCPSGCQCS-QPQTVFCTARQGTTVPRDVPPDTVGLYVFENGITMLDAGSFAGLPG 77
Query: 112 LEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIE 171
L++L LS+N + + G F L +L+ L+L NRL + + F L +L L+L N I
Sbjct: 78 LQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRGLRRLERLYLGKNRIR 137
Query: 172 SIPSYAFNRVPSLRRLDLGE---------------LKRLEYISEAAFE-GLVN------L 209
I AF+ + L L L + L L + S A E G+++ L
Sbjct: 138 HIQPGAFDTLDRLLELKLQDNELRALPPLRLPRLLLLDLSHNSLLALEPGILDTANVEAL 197
Query: 210 RYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLM-HAQVATI 268
R LG+ L D + L L +L++S N+L+ + P +GL L +L L + ++A +
Sbjct: 198 RLAGLGLQQL-DEGLFSRLRNLHDLDVSDNQLERV-PPVIRGLRGLTRLRLAGNTRIAQL 255
Query: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKE 328
L +L+EL++S+ +L +LP DL RL + NP++C C + W W++E
Sbjct: 256 RPEDLAGLAALQELDVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRE 315
Query: 329 TVPSNTTCCA----RCHAPAGLKGRYIGELDQSHFTCYA-----------PVIVEP---- 369
S+ T + RCH P GR + ELD + F C A PV+ EP
Sbjct: 316 ---SHVTLASPEETRCHFPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALS 372
Query: 370 ----PTDLNVTE 377
PT L+ TE
Sbjct: 373 SSLAPTWLSPTE 384
>gi|13375646 leucine rich repeat and fibronectin type III domain
containing 3 [Homo sapiens]
Length = 628
Score = 135 bits (340), Expect = 1e-31
Identities = 123/432 (28%), Positives = 176/432 (40%), Gaps = 77/432 (17%)
Query: 47 AGGGSPPATS----CPVACSCSNQAS--RVICTRRDLAEVPASIPVNTRYLNLQENGIQV 100
A SPP ++ CP C C Q+ V+C L VP S+ L L +N I
Sbjct: 14 APASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLADNFIAS 73
Query: 101 IRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKL 160
+R ++ L L LS+N +R + GAF L +L L L NRLT++ L L
Sbjct: 74 VRRRDLANMTGLLHLSLSRNTIRHVAAGAFADLRALRALHLDGNRLTSLGEGQLRGLVNL 133
Query: 161 RELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLK 220
R L L NN + ++ + A + D E L L+L NL+
Sbjct: 134 RHLILSNNQLAALAAGALD--------DCAE----------------TLEDLDLSYNNLE 169
Query: 221 DIP--NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKS 278
+P L L + L L N L + G+F L L +L
Sbjct: 170 QLPWEALGRLGNVNTLGLDHNLLASVPAGAFSRLHKLARL-------------------- 209
Query: 279 LEELNLSHNNLMSLPHD-LFTPLHRLER----------VHLNHNPWHCNCDVLWLSWWLK 327
+++ N L ++P D LF+ L L R + NP HCNC+++WL +
Sbjct: 210 ----DMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWLRRLAR 265
Query: 328 ETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCR- 386
E + CA +P L GRY + + F C PV+ L V G A L+CR
Sbjct: 266 E---DDLEACA---SPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRA 319
Query: 387 TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTT 446
G V W++P G L+ + S R +GTL D G +TC+ N+AG T
Sbjct: 320 VGDPEPRVRWVSPQGRLLGNSS---RARAFPNGTLELLVTEPGDGGIFTCIAANAAGEAT 376
Query: 447 ASATLNVSAVDP 458
A+ L V P
Sbjct: 377 AAVELTVGPPPP 388
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 134 bits (338), Expect = 2e-31
Identities = 127/501 (25%), Positives = 206/501 (41%), Gaps = 98/501 (19%)
Query: 57 CPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIR--T 103
CP C+C +AS V C L PA +P NT+ L LQ N I I T
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 104 DTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLREL 163
D +L L++ Q + + V I V +P L ++ L +N+LT +P + LS L+EL
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINV---KKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 164 W------------------------LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYIS 199
+ L +N ++ I S F+ +P+L L +GE + I
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIK 204
Query: 200 EAAFEGLVNLRYLNLGMCNLKDIPN--------------------------LTALVRLEE 233
+ F+ L+NLR L + NL +IP+ L +V L+
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKF 264
Query: 234 LELSGNRLDLIRPGSFQGLTSLRKLWL--------------------------MHAQVAT 267
L+L+ N ++ IR G F + L++L + + +++
Sbjct: 265 LDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSY 324
Query: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327
I NAF L LE L L+ N L +L H L L+ + ++ NP C+C + W++ K
Sbjct: 325 IHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMN-MNK 383
Query: 328 ETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP---PTDLNVTEGMAAELK 384
+ C P +G+ + ++ ++ P P++LNV G
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFH 443
Query: 385 CR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
CR T + W+TP+G + + + V +GTL+ VT ++ G YTC+ TN G
Sbjct: 444 CRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVG 503
Query: 444 NTTASATLNVSAVDPVAAGGT 464
S + V P G+
Sbjct: 504 ADLKSVMIKVDGSFPQDNNGS 524
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 134 bits (338), Expect = 2e-31
Identities = 127/501 (25%), Positives = 206/501 (41%), Gaps = 98/501 (19%)
Query: 57 CPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIR--T 103
CP C+C +AS V C L PA +P NT+ L LQ N I I T
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 104 DTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLREL 163
D +L L++ Q + + V I V +P L ++ L +N+LT +P + LS L+EL
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINV---KKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 164 W------------------------LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYIS 199
+ L +N ++ I S F+ +P+L L +GE + I
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIK 204
Query: 200 EAAFEGLVNLRYLNLGMCNLKDIPN--------------------------LTALVRLEE 233
+ F+ L+NLR L + NL +IP+ L +V L+
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKF 264
Query: 234 LELSGNRLDLIRPGSFQGLTSLRKLWL--------------------------MHAQVAT 267
L+L+ N ++ IR G F + L++L + + +++
Sbjct: 265 LDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSY 324
Query: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327
I NAF L LE L L+ N L +L H L L+ + ++ NP C+C + W++ K
Sbjct: 325 IHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMN-MNK 383
Query: 328 ETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP---PTDLNVTEGMAAELK 384
+ C P +G+ + ++ ++ P P++LNV G
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFH 443
Query: 385 CR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
CR T + W+TP+G + + + V +GTL+ VT ++ G YTC+ TN G
Sbjct: 444 CRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVG 503
Query: 444 NTTASATLNVSAVDPVAAGGT 464
S + V P G+
Sbjct: 504 ADLKSVMIKVDGSFPQDNNGS 524
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 134 bits (338), Expect = 2e-31
Identities = 127/501 (25%), Positives = 206/501 (41%), Gaps = 98/501 (19%)
Query: 57 CPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIR--T 103
CP C+C +AS V C L PA +P NT+ L LQ N I I T
Sbjct: 29 CPRLCTCEIRPWFTPRSIYMEASTVDCNDLGLLTFPARLPANTQILLLQTNNIAKIEYST 88
Query: 104 DTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLREL 163
D +L L++ Q + + V I V +P L ++ L +N+LT +P + LS L+EL
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINV---KKMPQLLSVYLEENKLTELPEKCLSELSNLQEL 145
Query: 164 W------------------------LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYIS 199
+ L +N ++ I S F+ +P+L L +GE + I
Sbjct: 146 YINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGE-NPIIRIK 204
Query: 200 EAAFEGLVNLRYLNLGMCNLKDIPN--------------------------LTALVRLEE 233
+ F+ L+NLR L + NL +IP+ L +V L+
Sbjct: 205 DMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKF 264
Query: 234 LELSGNRLDLIRPGSFQGLTSLRKLWL--------------------------MHAQVAT 267
L+L+ N ++ IR G F + L++L + + +++
Sbjct: 265 LDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPDLRKIEATNNPRLSY 324
Query: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327
I NAF L LE L L+ N L +L H L L+ + ++ NP C+C + W++ K
Sbjct: 325 IHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPIRCDCVIRWMN-MNK 383
Query: 328 ETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP---PTDLNVTEGMAAELK 384
+ C P +G+ + ++ ++ P P++LNV G
Sbjct: 384 TNIRFMEPDSLFCVDPPEFQGQNVRQVHFRDMMEICLPLIAPESFPSNLNVEAGSYVSFH 443
Query: 385 CR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
CR T + W+TP+G + + + V +GTL+ VT ++ G YTC+ TN G
Sbjct: 444 CRATAEPQPEIYWITPSGQKLLPNTLTDKFYVHSEGTLDINGVTPKEGGLYTCIATNLVG 503
Query: 444 NTTASATLNVSAVDPVAAGGT 464
S + V P G+
Sbjct: 504 ADLKSVMIKVDGSFPQDNNGS 524
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 134 bits (336), Expect = 4e-31
Identities = 105/329 (31%), Positives = 145/329 (44%), Gaps = 31/329 (9%)
Query: 13 PPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR--- 69
PP + S P G L L + G + G +CP AC CS
Sbjct: 35 PPPQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADEL 94
Query: 70 -VICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEI-------------- 114
V C+ R+L +P +P T+ L L N + + F++L L
Sbjct: 95 SVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQ 154
Query: 115 ----------LQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELW 164
L L +N +R + +G F P+L +L L +NRL+ + FE L L +L
Sbjct: 155 ALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLN 214
Query: 165 LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN 224
L N + +P AF + SLR L L RL Y+ A F GL LR L+L L+ I
Sbjct: 215 LGWNSLAVLPDAAFRGLGSLRELVLAG-NRLAYLQPALFSGLAELRELDLSRNALRAIKA 273
Query: 225 --LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEEL 282
L RL++L L N + + PG+F GL +LR L L H +VA + + F L L L
Sbjct: 274 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 333
Query: 283 NLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
LSHN + SL F LH LE + L HN
Sbjct: 334 RLSHNAIASLRPRTFKDLHFLEELQLGHN 362
Score = 111 bits (277), Expect = 3e-24
Identities = 84/249 (33%), Positives = 121/249 (48%), Gaps = 27/249 (10%)
Query: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
R L+L N ++ I+ + F L L+ L L +NL+ + GAF GL +L L+L NR+
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
+ F L LR L L +N I S+ F + L L LG R+ ++E +FEGL
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH-NRIRQLAERSFEGLGQ 377
Query: 209 LRYLNL--------------GMCN----------LKDIPN--LTALVRLEELELSGNRLD 242
L L L G+ N L+++P L +L L L G+ L
Sbjct: 378 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG 437
Query: 243 LIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR 302
IRP +F GL+ LR+L+L + IE + L L EL+L+ N L LPH LF L +
Sbjct: 438 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
Query: 303 LERVHLNHN 311
LE + L+ N
Sbjct: 498 LEYLLLSRN 506
Score = 107 bits (268), Expect = 3e-23
Identities = 85/252 (33%), Positives = 117/252 (46%), Gaps = 25/252 (9%)
Query: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
R L L N I +R TFK L LE LQL N +R++ +F GL L L L N+L
Sbjct: 331 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 390
Query: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
V AF L+ + + L N + ++P F + L L L E L I F GL
Sbjct: 391 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHL-EGSCLGRIRPHTFTGLSG 449
Query: 209 LRYLNL---GMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265
LR L L G+ +++ +L L L EL+L+ N+L + FQGL L L L ++
Sbjct: 450 LRRLFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 508
Query: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR--------------------LER 305
A + +A L+ L++SHN L +LP+ L PL R LER
Sbjct: 509 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
Query: 306 VHLNHNPWHCNC 317
+ L NPW C C
Sbjct: 569 LWLEGNPWDCGC 580
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 134 bits (336), Expect = 4e-31
Identities = 117/402 (29%), Positives = 171/402 (42%), Gaps = 59/402 (14%)
Query: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
L+L N I++I TF+ L LE+L+L +N + K+ GAF GL ++ L L N L V
Sbjct: 216 LDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVN 275
Query: 151 TQAFEYLSKLRELWLRNNPIESIPS-------------YAFNRVPSLRRLDLGELKRLE- 196
+ + L+ L +L L NN I I +FN + L L EL L
Sbjct: 276 SGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSV 335
Query: 197 ---------YISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPG 247
+I+E AF+GL +LR L+L + E+SG D G
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLDL-----------------DHNEISGTIEDT--SG 376
Query: 248 SFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVH 307
+F GL SL KL L ++ ++ + AF L+ LE LNL N + S+ D F + L+ +H
Sbjct: 377 AFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKNLKELH 436
Query: 308 LNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAP 364
++ + + C+C + WL WL + A C P LKG+ I + F C P
Sbjct: 437 ISSDSFLCDCQLKWLPPWLIGRM-LQAFVTATCAHPESLKGQSIFSVPPESFVCDDFLKP 495
Query: 365 VIVEPPTDLNVTEGMAAELKCRTGTSMTS---VNWLTPNGTLMTHGSYRVRISVLHDG-- 419
I+ P G C +S +S W N L DG
Sbjct: 496 QIITQPETTMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEV 555
Query: 420 -----TLNFTNVTVQDTGQYTCMVTNSAGNT---TASATLNV 453
L+ VT G+Y C++TN G+T A T+NV
Sbjct: 556 MEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNV 597
Score = 95.9 bits (237), Expect = 1e-19
Identities = 87/292 (29%), Positives = 137/292 (46%), Gaps = 20/292 (6%)
Query: 24 LLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAEVPAS 83
LL LWL L VT+AAG P C AC+C+ + + C R LA +P
Sbjct: 18 LLLLWLLLLRLEP------VTAAAG----PRAPCAAACTCAGDS--LDCGGRGLAALPGD 65
Query: 84 IPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELF- 142
+P TR LNL N + I F+ L +L+ + L+ N + + G S + + LF
Sbjct: 66 LPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPS---LGAASSHVVSLFL 122
Query: 143 -DNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEA 201
N++ +V + L L L N I + + F P ++ L+L R+ +
Sbjct: 123 QHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAG-NRIGTLELG 181
Query: 202 AFEGLV-NLRYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLW 259
AF+GL +L L L + +P L RL +L+L+ NR+ LI +FQGL SL L
Sbjct: 182 AFDGLSRSLLTLRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLK 241
Query: 260 LMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
L ++ + AF L + L+L +N+L+ + L L ++HL++N
Sbjct: 242 LQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNN 293
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/382 (26%), Positives = 151/382 (39%), Gaps = 47/382 (12%)
Query: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVR---KIEVGAFNGLPSLNTLELFDNRLT 147
L L N I I FK LR L +L L N + + GAF+GL SL+ L LF N++
Sbjct: 336 LRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIK 395
Query: 148 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLV 207
+V +AF L L L L N I S+ AF ++ + LK L +IS +F
Sbjct: 396 SVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMKN--------LKEL-HISSDSFLCDC 446
Query: 208 NLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVAT 267
L++L + +TA E L G + + P SF L+ + Q T
Sbjct: 447 QLKWLPPWLIGRMLQAFVTATCAHPE-SLKGQSIFSVPPESFVCDDFLKPQII--TQPET 503
Query: 268 IERNAFDDLKSLEELNLSHNNLMSLP----HDLFTPLHRLERVHLNHNPWHCNCDVLWLS 323
D++ S ++ M+ +++ T VH++
Sbjct: 504 TMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGE--------- 554
Query: 324 WWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYA----------PVIVEPPTDL 373
V TT G +GRY + + Y+ P + P D+
Sbjct: 555 ------VMEYTTILHLRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDI 608
Query: 374 NVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNF-TNVTVQDT 431
+ A L+C TG + W GT R R+ V+ D + F T+V + D
Sbjct: 609 TIRTTTMARLECAATGHPNPQIAWQKDGGTDFPAARER-RMHVMPDDDVFFITDVKIDDA 667
Query: 432 GQYTCMVTNSAGNTTASATLNV 453
G Y+C NSAG+ +A+ATL V
Sbjct: 668 GVYSCTAQNSAGSISANATLTV 689
Score = 38.9 bits (89), Expect = 0.017
Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 6/106 (5%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCR-TGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P +V P D V+ G L+C+ TG + W + L S R + D L
Sbjct: 693 PSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKGDRPL----SLTERHHLTPDNQLL 748
Query: 423 FT-NVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSG 467
NV +D G+YTC ++N+ G A + L+V GT G
Sbjct: 749 VVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAAGCRKDGTTVG 794
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 133 bits (335), Expect = 5e-31
Identities = 107/379 (28%), Positives = 171/379 (45%), Gaps = 37/379 (9%)
Query: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
L +Q NG+ + F L ++EILQL N + +I G GL L L L N + +
Sbjct: 244 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 303
Query: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210
A+E+ KL EL L N + + +F + L L +G R+ YI++ AF GL +L+
Sbjct: 304 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGN-NRVSYIADCAFRGLSSLK 362
Query: 211 YLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER 270
L D+ N +E++ G+F GL LR+L L ++ +I +
Sbjct: 363 TL--------DLKNNEISWTIEDMN-----------GAFSGLDKLRRLILQGNRIRSITK 403
Query: 271 NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV 330
AF L +LE L+LS N +MSL + F+ + +L+++HLN + C+C + WL W+ E
Sbjct: 404 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN- 462
Query: 331 PSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMAAELKCRT 387
+ A C P LKGR I + F C P I P + +G C
Sbjct: 463 NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSA 522
Query: 388 GTSMTSV--------NWLTPNGTLMTHGSYRVRISVLHDGT--LNFTNVTVQDTGQYTCM 437
+S S N L + + + R + + + T L V G+Y C+
Sbjct: 523 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 582
Query: 438 VTNSAGNT---TASATLNV 453
++N G++ A T+N+
Sbjct: 583 ISNHFGSSYSVKAKLTVNM 601
Score = 86.3 bits (212), Expect = 9e-17
Identities = 79/283 (27%), Positives = 130/283 (45%), Gaps = 18/283 (6%)
Query: 40 GVAVTSAAGG----GSPPATS----CPVACSCSNQASRVICTRRDLAEVPASIPVNTRYL 91
G A S +GG G P + CP C C + C+R+ LA +P +P L
Sbjct: 22 GRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDL--LDCSRKRLARLPEPLPSWVARL 79
Query: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKI-EVGAFNGLPSLNTLELFDNRLTTVP 150
+L N + I+ + HL+ L ++L+ N + I +G + ++ L L NR+ +
Sbjct: 80 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEIL 137
Query: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-L 209
+ + L L L +N I + + AF + L+ L L R+ + F+ L N L
Sbjct: 138 PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 194
Query: 210 RYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268
L L + IP + L +L+ LEL+ N++ + +FQGL +L+ L + V +
Sbjct: 195 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 254
Query: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
AF L ++E L L HNNL + L L+ +HL+ N
Sbjct: 255 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 297
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 1/91 (1%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P + P DL + G A L+C G + W GT R + D
Sbjct: 603 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 662
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+V ++D G Y+C NSAG+ +A+ATL V
Sbjct: 663 IVDVKIEDIGVYSCTAQNSAGSISANATLTV 693
Score = 37.4 bits (85), Expect = 0.049
Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMT-SVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P + P D VT+G A L+C G S +NW + L+ + + L
Sbjct: 697 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 753
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+ V D G+YTC ++N+ G + L+V
Sbjct: 754 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 784
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 133 bits (335), Expect = 5e-31
Identities = 107/379 (28%), Positives = 171/379 (45%), Gaps = 37/379 (9%)
Query: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
L +Q NG+ + F L ++EILQL N + +I G GL L L L N + +
Sbjct: 184 LKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRIS 243
Query: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210
A+E+ KL EL L N + + +F + L L +G R+ YI++ AF GL +L+
Sbjct: 244 PDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGN-NRVSYIADCAFRGLSSLK 302
Query: 211 YLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER 270
L D+ N +E++ G+F GL LR+L L ++ +I +
Sbjct: 303 TL--------DLKNNEISWTIEDMN-----------GAFSGLDKLRRLILQGNRIRSITK 343
Query: 271 NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV 330
AF L +LE L+LS N +MSL + F+ + +L+++HLN + C+C + WL W+ E
Sbjct: 344 KAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN- 402
Query: 331 PSNTTCCARCHAPAGLKGRYIGELDQSHFTC---YAPVIVEPPTDLNVTEGMAAELKCRT 387
+ A C P LKGR I + F C P I P + +G C
Sbjct: 403 NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFICSA 462
Query: 388 GTSMTSV--------NWLTPNGTLMTHGSYRVRISVLHDGT--LNFTNVTVQDTGQYTCM 437
+S S N L + + + R + + + T L V G+Y C+
Sbjct: 463 ASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCV 522
Query: 438 VTNSAGNT---TASATLNV 453
++N G++ A T+N+
Sbjct: 523 ISNHFGSSYSVKAKLTVNM 541
Score = 67.4 bits (163), Expect = 4e-11
Identities = 61/223 (27%), Positives = 105/223 (47%), Gaps = 8/223 (3%)
Query: 92 NLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKI-EVGAFNGLPSLNTLELFDNRLTTVP 150
+L N + I+ + HL+ L ++L+ N + I +G + ++ L L NR+ +
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEIL 77
Query: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN-L 209
+ + L L L +N I + + AF + L+ L L R+ + F+ L N L
Sbjct: 78 PEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNS-NRVTSMEPGYFDNLANTL 134
Query: 210 RYLNLGMCNLKDIP-NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268
L L + IP + L +L+ LEL+ N++ + +FQGL +L+ L + V +
Sbjct: 135 LVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKL 194
Query: 269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
AF L ++E L L HNNL + L L+ +HL+ N
Sbjct: 195 MDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQN 237
Score = 48.1 bits (113), Expect = 3e-05
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 1/91 (1%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P + P DL + G A L+C G + W GT R + D
Sbjct: 543 PSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFF 602
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+V ++D G Y+C NSAG+ +A+ATL V
Sbjct: 603 IVDVKIEDIGVYSCTAQNSAGSISANATLTV 633
Score = 37.4 bits (85), Expect = 0.049
Identities = 25/91 (27%), Positives = 40/91 (43%), Gaps = 4/91 (4%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRTGTSMT-SVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
P + P D VT+G A L+C G S +NW + L+ + + L
Sbjct: 637 PSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERH---FFAAGNQLLI 693
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNV 453
+ V D G+YTC ++N+ G + L+V
Sbjct: 694 IVDSDVSDAGKYTCEMSNTLGTERGNVRLSV 724
Score = 33.5 bits (75), Expect = 0.70
Identities = 30/111 (27%), Positives = 47/111 (42%), Gaps = 25/111 (22%)
Query: 224 NLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIER------------- 270
+L L + +LS NRL I+ S L SLR++ L + ++ TI
Sbjct: 9 SLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSL 68
Query: 271 ----------NAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
+ +SLE L+LS NN+ L P +L+ ++LN N
Sbjct: 69 AGNRIVEILPEHLKEFQSLETLDLSSNNISEL--QTAFPALQLKYLYLNSN 117
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 133 bits (334), Expect = 7e-31
Identities = 95/287 (33%), Positives = 132/287 (45%), Gaps = 12/287 (4%)
Query: 170 IESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTA 227
+E++P+ A P LDL R+ I AF L NL L L +K IP+
Sbjct: 54 LEAVPAVA----PQTSILDL-RFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFED 108
Query: 228 LVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHN 287
L L+ L L N + I +F+GL SL +L+L Q+ T++ ++F L LE L L +N
Sbjct: 109 LENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNN 168
Query: 288 NLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPS-NTTCCARCHAPAGL 346
+ L F L ++R+ L+ N HC+C++LWL+ LK S N A C P +
Sbjct: 169 RITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRI 228
Query: 347 KGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMT 405
+GR + + C P I P D +VT G CR G + WL N L
Sbjct: 229 QGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM 288
Query: 406 HGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNT-TASATL 451
R+++L DGTL N D G Y CM N AG T TL
Sbjct: 289 KTD--SRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTL 333
Score = 100 bits (250), Expect = 4e-21
Identities = 114/435 (26%), Positives = 171/435 (39%), Gaps = 65/435 (14%)
Query: 53 PATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHL 112
P CP C C R C L VPA P T L+L+ N I+ I+ F+ LR+L
Sbjct: 32 PGAGCPSRCLCFRTTVR--CMHLLLEAVPAVAP-QTSILDLRFNRIREIQPGAFRRLRNL 88
Query: 113 EILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIES 172
L L+ N +++I GAF L +L L L+ N + ++ QAF+ L+ L +L+L N IE+
Sbjct: 89 NTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIET 148
Query: 173 IPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLK-DIPNLTALVRL 231
+ +F +P L RL L R+ ++ F L +++ L L L D L L
Sbjct: 149 LDPDSFQHLPKLERLFLHN-NRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLL 207
Query: 232 EELELSGNRLDLI---RPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNN 288
+ SGN P QG VATI + EELN
Sbjct: 208 KTYAESGNAQAAAICEYPRRIQG-----------RSVATI---------TPEELNCERPR 247
Query: 289 LMSLPHDL----FTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPA 344
+ S P D ++ R N P +++WL + T
Sbjct: 248 ITSEPQDADVTSGNTVYFTCRAEGNPKP-----EIIWLR--NNNELSMKTDSRLNLLDDG 300
Query: 345 GLKGRYIGELDQSHFTCYA----------------------PVIVEPPTDLNVTEGMAAE 382
L + E DQ + C A P V P + V G +
Sbjct: 301 TLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVT 360
Query: 383 LKC-RTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNS 441
L+C TG ++W + T + R+++ G L NV D+G+Y C TN+
Sbjct: 361 LECSATGHPPPRISWTRGDRTPL---PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNN 417
Query: 442 AGNTTASATLNVSAV 456
+ A+A + V A+
Sbjct: 418 IDSVHATAFIIVQAL 432
Score = 43.1 bits (100), Expect = 9e-04
Identities = 36/114 (31%), Positives = 46/114 (40%), Gaps = 9/114 (7%)
Query: 354 LDQSHFTCYAPVIVEP-----PTDLNVTEGMAAELKCRTGTSMTSVNWLTPNGTLMTHGS 408
+D H T + V P P D V EG + +C + V T G+ + S
Sbjct: 418 IDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQL---S 474
Query: 409 YRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVS-AVDPVAA 461
R VL GTL + V + D GQY C N G+ A L V V PV A
Sbjct: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFA 528
Score = 41.6 bits (96), Expect = 0.003
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 5/95 (5%)
Query: 364 PVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLN 422
PV P+D V G +L C + G ++ W +G +T + + +G L
Sbjct: 525 PVFASIPSDTTVEVGANVQLPCSSQGEPEPAITW-NKDGVQVTESG---KFHISPEGFLT 580
Query: 423 FTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVD 457
+V D G+Y C+ N+ G+ + S L+V+ D
Sbjct: 581 INDVGPADAGRYECVARNTIGSASVSMVLSVNVPD 615
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 132 bits (333), Expect = 9e-31
Identities = 88/267 (32%), Positives = 137/267 (51%), Gaps = 7/267 (2%)
Query: 86 VNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR 145
+N R L LQ N + + F L ++ L L +N + + G F G+ +L L+L +N
Sbjct: 132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNN 191
Query: 146 LTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEG 205
+ + F++L L L+L +N + +PS AF + SLRRL L +E I AF+G
Sbjct: 192 ILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSH-NPIEAIQPFAFKG 250
Query: 206 LVNLRYLNLGMCNLKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHA 263
L NL YL L ++++ + + L+ L LS N L+ + +F L +L L L
Sbjct: 251 LANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRN 310
Query: 264 QVATIERNAFDDL-KSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL 322
++ +I+ + F+++ SL+ LNLS NNL +L + PL L + N NPW CNC +L L
Sbjct: 311 RIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSNPWECNCKLLGL 370
Query: 323 SWWLKETVPSNTTCCARCHAPAGLKGR 349
WL S T C P ++GR
Sbjct: 371 RDWL---ASSAITLNIYCQNPPSMRGR 394
Score = 58.9 bits (141), Expect = 2e-08
Identities = 40/119 (33%), Positives = 62/119 (52%), Gaps = 2/119 (1%)
Query: 195 LEYISEAAFEGLVNLRYLNLGMCNLKDI--PNLTALVRLEELELSGNRLDLIRPGSFQGL 252
+ YI+E+ GL +L L L N+ + L L L L+ N + + PG F+GL
Sbjct: 72 ISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGL 131
Query: 253 TSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
+LR L+L + QV+ + R F+DL S++ LNL N L L F + L + L++N
Sbjct: 132 LNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNN 190
Score = 30.0 bits (66), Expect = 7.8
Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 12/125 (9%)
Query: 65 NQASRVICTRRDLAEVPA---SIPVNTRYLNLQENGIQVIRTDTFKHL-RHLEILQLSKN 120
N +I + DL + + S+ N YL L N I I DTF+++ L+IL LS N
Sbjct: 276 NNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFN 335
Query: 121 LVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNR 180
+ + L SL L+ N P + L LR+ WL ++ I ++ Y N
Sbjct: 336 NLTALHPRVLKPLSSLIHLQANSN-----PWECNCKLLGLRD-WLASSAI-TLNIYCQN- 387
Query: 181 VPSLR 185
PS+R
Sbjct: 388 PPSMR 392
>gi|153251229 chondroadherin precursor [Homo sapiens]
Length = 359
Score = 132 bits (333), Expect = 9e-31
Identities = 101/331 (30%), Positives = 149/331 (45%), Gaps = 34/331 (10%)
Query: 52 PPATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFK---- 107
P +CP C C + VIC + L ++P + T+ LNLQ N V+ ++F+
Sbjct: 18 PALAACPQNCHCHSDLQHVICDKVGLQKIP-KVSEKTKLLNLQRNNFPVLAANSFRAMPN 76
Query: 108 ----HLRHLEI----------------LQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLT 147
HL+H +I L LS N +R + GAF+ L L L L N++T
Sbjct: 77 LVSLHLQHCQIREVAAGAFRGLKQLIYLYLSHNDIRVLRAGAFDDLTELTYLYLDHNKVT 136
Query: 148 TVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLV 207
+P L L L L NN I + + AF LR L L E L + A + +
Sbjct: 137 ELPRGLLSPLVNLFILQLNNNKIRELRAGAFQGAKDLRWLYLSE-NALSSLQPGALDDVE 195
Query: 208 NLRYLNLGMCNLKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTS-LRKLWLMHAQ 264
NL ++ L P+ L+ L +EEL+LS N L I +FQ L LWL +
Sbjct: 196 NLAKFHVDRNQLSSYPSAALSKLRVVEELKLSHNPLKSIPDNAFQSFGRYLETLWLDNTN 255
Query: 265 VATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSW 324
+ AF + +L+ ++L +N L LP + P LE + L +NPW C C + L
Sbjct: 256 LEKFSDGAFLGVTTLKHVHLENNRLNQLPSNF--PFDSLETLALTNNPWKCTCQLRGLRR 313
Query: 325 WLKETVPSNTTCCARCHAPAGLKGRYIGELD 355
WL+ CA +PA KG++I + D
Sbjct: 314 WLEAKASRPDATCA---SPAKFKGQHIRDTD 341
>gi|149773484 leucine rich repeat and fibronectin type III domain
containing 1 [Homo sapiens]
Length = 771
Score = 131 bits (329), Expect = 2e-30
Identities = 122/435 (28%), Positives = 179/435 (41%), Gaps = 79/435 (18%)
Query: 29 LFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASRV--ICTRRDLAEVPASIPV 86
L SPP A + + + A G P CP C C N A + +C + L VP +I
Sbjct: 10 LLSPPPAALPFLLLLWAGASRGQP----CPGRCICQNVAPTLTMLCAKTGLLFVPPAID- 64
Query: 87 NTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRL 146
R + L+L+ N + + F + SL L L N +
Sbjct: 65 -----------------------RRVVELRLTDNFIAAVRRRDFANMTSLVHLTLSRNTI 101
Query: 147 TTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGL 206
V AF L LR L L +N + + + +LR L LG ++ + AAF+
Sbjct: 102 GQVAAGAFADLRALRALHLDSNRLAEVRGDQLRGLGNLRHLILGN-NQIRRVESAAFDAF 160
Query: 207 VNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVA 266
++ +E+L+LS N L+ + + + +L L L H +
Sbjct: 161 LST---------------------VEDLDLSYNNLEALPWEAVGQMVNLNTLTLDHNLID 199
Query: 267 TIERNAFDDLKSLEELNLSHNNLMSLPHD-LF-----------TPLHRLERVHLNHNPWH 314
I F L L L+++ N L LP D LF TPL V NP H
Sbjct: 200 HIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGTGPKPPTPL----TVSFGGNPLH 255
Query: 315 CNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLN 374
CNC++LWL +E C P L RY + + F C P+I
Sbjct: 256 CNCELLWLRRLTREDDLET------CATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRA 309
Query: 375 -VTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTG 432
V EG A L+CR G V+W+ P+G L+ + S R V DGTL+ T T++D+G
Sbjct: 310 LVVEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSS---RTRVRGDGTLDVTITTLRDSG 366
Query: 433 QYTCMVTNSAGNTTA 447
+TC+ +N+AG TA
Sbjct: 367 TFTCIASNAAGEATA 381
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 130 bits (328), Expect = 3e-30
Identities = 95/295 (32%), Positives = 130/295 (44%), Gaps = 28/295 (9%)
Query: 165 LRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN 224
LR N I IP AF ++ +L L L + IS AFEGL NL YL L
Sbjct: 57 LRFNRIREIPGSAFKKLKNLNTLLLNN-NHIRKISRNAFEGLENLLYLYLYK-------- 107
Query: 225 LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNL 284
N + + +F+GL SL L++ Q+ ++ F DL LE L L
Sbjct: 108 --------------NEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFL 153
Query: 285 SHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETVP-SNTTCCARCHAP 343
+N L +P F+ L L+R+ L+ N C+CD++WL L+ +T A C P
Sbjct: 154 HNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYP 213
Query: 344 AGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGT 402
L GR + + F C +P I P D+ V G CR G + W+ N +
Sbjct: 214 RRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHS 273
Query: 403 LMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNT-TASATLNVSAV 456
L R++V DGTL N D G Y CM NSAG T SA L S++
Sbjct: 274 LDLEDD--TRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSL 326
Score = 93.6 bits (231), Expect = 6e-19
Identities = 114/432 (26%), Positives = 167/432 (38%), Gaps = 63/432 (14%)
Query: 53 PATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHL 112
P CP C C S V C L +P +P T L+L+ N I+ I FK L++L
Sbjct: 20 PGLPCPSRCLCFK--STVRCMHLMLDHIP-QVPQQTTVLDLRFNRIREIPGSAFKKLKNL 76
Query: 113 EILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIES 172
L L+ N +RKI AF GL +L L L+ N + + Q F+ L L L++ N +E
Sbjct: 77 NTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEM 136
Query: 173 IPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLE 232
+ F + L RL L +L I +F L +L+ L L + ALV
Sbjct: 137 LQPETFGDLLRLERLFLHN-NKLSKIPAGSFSNLDSLKRLRL---------DSNALVCDC 186
Query: 233 ELELSGNRLD-LIRPGSFQGLTSLRKLWLMHAQ-VATIERNAFDDLKSLEELNLSHNNLM 290
+L G L + G Q + +H + VA++ ++EE N +
Sbjct: 187 DLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASV---------TVEEFNCQSPRIT 237
Query: 291 SLPHDLFTP----LHRLERVHLNHNPWHCNCDVLWLSWWLKETVPSNTTCCARCHAPAGL 346
P D+ P ++ R N P +++W+ ++ L
Sbjct: 238 FEPQDVEVPSGNTVYFTCRAEGNPKP-----EIIWIH--NNHSLDLEDDTRLNVFDDGTL 290
Query: 347 KGRYIGELDQSHFTCYA----------------------PVIVEPPTDLNVTEGMAAELK 384
R E DQ + C A P V P D V G + L+
Sbjct: 291 MIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLE 350
Query: 385 C-RTGTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
C TG + W NG L GS V S L N+T +D G++TC NS G
Sbjct: 351 CMATGHPHPLITWTRDNG-LELDGSRHVATS----SGLYLQNITQRDHGRFTCHANNSHG 405
Query: 444 NTTASATLNVSA 455
A+A + V A
Sbjct: 406 TVQAAANIIVQA 417
Score = 43.5 bits (101), Expect = 7e-04
Identities = 37/129 (28%), Positives = 47/129 (36%), Gaps = 23/129 (17%)
Query: 344 AGLKGRYIGELDQSHFTCYAP-----------VIVEPPTDLNVT-------EGMAAELKC 385
+GL + I + D FTC+A +IV+ P VT E A E C
Sbjct: 381 SGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLC 440
Query: 386 RT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAGN 444
G + W G L G + +VL GTL D GQY C +S G
Sbjct: 441 EADGNPPPVIVWTKTGGQLPVEGQH----TVLSSGTLRIDRAAQHDQGQYECQAVSSLGV 496
Query: 445 TTASATLNV 453
S L V
Sbjct: 497 KKVSVQLTV 505
Score = 37.4 bits (85), Expect = 0.049
Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 5/99 (5%)
Query: 365 VIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNF 423
V + P D +V G + C G + W + G + V +GTL
Sbjct: 512 VFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVD----DEGTLTI 567
Query: 424 TNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDPVAAG 462
+ D G+Y C+ NS G + L V+A+ AG
Sbjct: 568 YDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAG 606
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 130 bits (328), Expect = 3e-30
Identities = 104/320 (32%), Positives = 150/320 (46%), Gaps = 32/320 (10%)
Query: 54 ATSCPVACSCSNQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLE 113
A SCP+ C+C + V C + + VP S+P +T+ L LQ N I+ +R TF +L
Sbjct: 28 APSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NLL 85
Query: 114 ILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR-LTTVPTQAFEYLSKLRELWLRNNPIES 172
L L N + I G F L +L L+L DNR L ++ F+ L +L+ L L + S
Sbjct: 86 TLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSS 145
Query: 173 IPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLE 232
+P F + SL+ L L E L ++ + F L NL +L L
Sbjct: 146 LPGNIFRGLVSLQYLYLQE-NSLLHLQDDLFADLANLSHLFL------------------ 186
Query: 233 ELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSL 292
GNRL L+ F+GL SL +L L ++ + R AF L L L L +N+L SL
Sbjct: 187 ----HGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASL 242
Query: 293 PHDLFTPLHRLERVHLNHNPWHCNCDV--LWLSWWLKETVPSNTTCCARCHAPAGLKGRY 350
P + L LE + LN NPW C+C LW +W+ + V S+ CA P +GR
Sbjct: 243 PGEALADLPSLEFLRLNANPWACDCRARPLW-AWFQRARVSSSDVTCA---TPPERQGRD 298
Query: 351 IGELDQSHFTCYAPVIVEPP 370
+ L ++ F P P
Sbjct: 299 LRALREADFQACPPAAPTRP 318
>gi|153791330 leucine rich repeat neuronal 1 [Homo sapiens]
Length = 716
Score = 130 bits (327), Expect = 4e-30
Identities = 129/491 (26%), Positives = 204/491 (41%), Gaps = 94/491 (19%)
Query: 55 TSCPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTRYLNLQENGIQVIRT 103
+ CP C C +A+ V C L +P+++ +T+ L LQ N I
Sbjct: 30 SECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPSNLSSDTQVLLLQSNNIAKT-V 88
Query: 104 DTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLREL 163
D + L +L L S+N I+ L L TL L +N++T + + LS L+EL
Sbjct: 89 DELQQLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQITEMTDYCLQDLSNLQEL 148
Query: 164 WLRNNPIESIPSYAFNRVPSLRRLDLGELK-------------RLEY----------ISE 200
++ +N I +I ++AF + +L RL L K LE I +
Sbjct: 149 YINHNQISTISAHAFAGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILD 208
Query: 201 AAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELE------------------------- 235
F+ L NLR L L L DIP ALV L+ LE
Sbjct: 209 MNFKPLANLRSLVLAGMYLTDIPG-NALVGLDSLESLSFYDNKLVKVPQLALQKVPNLKF 267
Query: 236 --LSGNRLDLIRPGSFQGLTSLRKLWLMH-AQVATIERNAFDDLKSLEELNLSHNNLMSL 292
L+ N + I+ G F+ + L++L + + ++ +++R A D+L L +L ++N +S
Sbjct: 268 LDLNKNPIHKIQEGDFKNMLRLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSY 327
Query: 293 PHDL-FTPLHRLERVHLNH------------------------NPWHCNCDVLWLSWWLK 327
H L F + LE + LN+ NP C+C + W++ K
Sbjct: 328 IHRLAFRSVPALESLMLNNNALNAIYQKTVESLPNLREISIHSNPLRCDCVIHWIN-SNK 386
Query: 328 ETVPSNTTCCARCHAPAGLKGRYIGE-LDQSHFTCYAPVIVEP--PTDLNVTEGMAAELK 384
+ C P KG + E L Q P+I P LNV G L
Sbjct: 387 TNIRFMEPLSMFCAMPPEYKGHQVKEVLIQDSSEQCLPMISHDSFPNRLNVDIGTTVFLD 446
Query: 385 CRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQDTGQYTCMVTNSAG 443
CR + W+TP G +T + + + +GTL +N+ ++D+G+YTC+ N G
Sbjct: 447 CRAMAEPEPEIYWVTPIGNKITVETLSDKYKLSSEGTLEISNIQIEDSGRYTCVAQNVQG 506
Query: 444 NTTASATLNVS 454
T AT+ V+
Sbjct: 507 ADTRVATIKVN 517
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 129 bits (325), Expect = 7e-30
Identities = 103/318 (32%), Positives = 141/318 (44%), Gaps = 36/318 (11%)
Query: 24 LLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR----VICTRRDLAE 79
LL W+ P G A G +CP AC CS V C+ R+L
Sbjct: 13 LLLSWVALGPRSLEGADPGTPGEAEG-----PACPAACVCSYDDDADELSVFCSSRNLTR 67
Query: 80 VPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEI------------------------L 115
+P +P T+ L L N + + F++L L L
Sbjct: 68 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 127
Query: 116 QLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPS 175
L +N +R + +G F P+L +L L +NRL+ + FE L L +L L N + +P
Sbjct: 128 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 187
Query: 176 YAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTALVRLEE 233
AF + SLR L L RL Y+ A F GL LR L+L L+ I L RL++
Sbjct: 188 AAFRGLGSLRELVLAG-NRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 246
Query: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
L L N + + PG+F GL +LR L L H +VA + + F L L L LSHN + SL
Sbjct: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306
Query: 294 HDLFTPLHRLERVHLNHN 311
F LH LE + L HN
Sbjct: 307 PRTFKDLHFLEELQLGHN 324
Score = 111 bits (277), Expect = 3e-24
Identities = 84/249 (33%), Positives = 121/249 (48%), Gaps = 27/249 (10%)
Query: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
R L+L N ++ I+ + F L L+ L L +NL+ + GAF GL +L L+L NR+
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
+ F L LR L L +N I S+ F + L L LG R+ ++E +FEGL
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGH-NRIRQLAERSFEGLGQ 339
Query: 209 LRYLNL--------------GMCN----------LKDIPN--LTALVRLEELELSGNRLD 242
L L L G+ N L+++P L +L L L G+ L
Sbjct: 340 LEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG 399
Query: 243 LIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR 302
IRP +F GL+ LR+L+L + IE + L L EL+L+ N L LPH LF L +
Sbjct: 400 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
Query: 303 LERVHLNHN 311
LE + L+ N
Sbjct: 460 LEYLLLSRN 468
Score = 107 bits (268), Expect = 3e-23
Identities = 85/252 (33%), Positives = 117/252 (46%), Gaps = 25/252 (9%)
Query: 89 RYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTT 148
R L L N I +R TFK L LE LQL N +R++ +F GL L L L N+L
Sbjct: 293 RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE 352
Query: 149 VPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVN 208
V AF L+ + + L N + ++P F + L L L E L I F GL
Sbjct: 353 VKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHL-EGSCLGRIRPHTFTGLSG 411
Query: 209 LRYLNL---GMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQV 265
LR L L G+ +++ +L L L EL+L+ N+L + FQGL L L L ++
Sbjct: 412 LRRLFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
Query: 266 ATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHR--------------------LER 305
A + +A L+ L++SHN L +LP+ L PL R LER
Sbjct: 471 AELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
Query: 306 VHLNHNPWHCNC 317
+ L NPW C C
Sbjct: 531 LWLEGNPWDCGC 542
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 129 bits (323), Expect = 1e-29
Identities = 129/506 (25%), Positives = 207/506 (40%), Gaps = 97/506 (19%)
Query: 41 VAVTSAAGGGSPPATSCPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTR 89
VA +AA P CP C+C +A+ V C L VP ++P T+
Sbjct: 13 VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQ 72
Query: 90 YLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTV 149
L LQ N I + +L +L L LS+N F+ LP L +L L +N+LT +
Sbjct: 73 TLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRL 132
Query: 150 PTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGEL----------------- 192
+F L+ L+EL+L +N + I AF+ + +L RL L
Sbjct: 133 EDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLE 192
Query: 193 ------KRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTALVRLEE----------- 233
+++ I + F L NLR L L NL++I + L L LE
Sbjct: 193 ILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARV 252
Query: 234 -------------LELSGNRLDLIRPGSFQGLTSLRKLWLMH-AQVATIERNAFDDLKSL 279
L+L+ N L + PG F + L++L L + ++ +I++ A +L L
Sbjct: 253 PRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPEL 312
Query: 280 EELNLSHNNLMSLPHD-LFTPLHRLERVHLNHN------------------------PWH 314
+L++++N +S H F L ++E + LN+N P
Sbjct: 313 TKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
Query: 315 CNCDVLWLS---WWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP-- 369
C+C + W + ++ P +T C P L+ + E+ T + ++ P
Sbjct: 373 CDCVIRWANATGTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMTDHCLPLISPRS 428
Query: 370 -PTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVT 427
P L V G + L CR + W+TP G +T R V +GTL VT
Sbjct: 429 FPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVT 488
Query: 428 VQDTGQYTCMVTNSAGNTTASATLNV 453
++ G YTC+ N G T + ++ V
Sbjct: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
>gi|42544231 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 129 bits (323), Expect = 1e-29
Identities = 129/506 (25%), Positives = 207/506 (40%), Gaps = 97/506 (19%)
Query: 41 VAVTSAAGGGSPPATSCPVACSCS-----------NQASRVICTRRDLAEVPASIPVNTR 89
VA +AA P CP C+C +A+ V C L VP ++P T+
Sbjct: 13 VAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALPAGTQ 72
Query: 90 YLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTV 149
L LQ N I + +L +L L LS+N F+ LP L +L L +N+LT +
Sbjct: 73 TLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRL 132
Query: 150 PTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGEL----------------- 192
+F L+ L+EL+L +N + I AF+ + +L RL L
Sbjct: 133 EDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNLE 192
Query: 193 ------KRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTALVRLEE----------- 233
+++ I + F L NLR L L NL++I + L L LE
Sbjct: 193 ILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARV 252
Query: 234 -------------LELSGNRLDLIRPGSFQGLTSLRKLWLMH-AQVATIERNAFDDLKSL 279
L+L+ N L + PG F + L++L L + ++ +I++ A +L L
Sbjct: 253 PRRALEQVPGLKFLDLNKNPLQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLPEL 312
Query: 280 EELNLSHNNLMSLPHD-LFTPLHRLERVHLNHN------------------------PWH 314
+L++++N +S H F L ++E + LN+N P
Sbjct: 313 TKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNPIR 372
Query: 315 CNCDVLWLS---WWLKETVPSNTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEP-- 369
C+C + W + ++ P +T C P L+ + E+ T + ++ P
Sbjct: 373 CDCVIRWANATGTRVRFIEPQSTLCA----EPPDLQRLPVREVPFREMTDHCLPLISPRS 428
Query: 370 -PTDLNVTEGMAAELKCRT-GTSMTSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVT 427
P L V G + L CR + W+TP G +T R V +GTL VT
Sbjct: 429 FPPSLQVASGESMVLHCRALAEPEPEIYWVTPAGLRLTPAHAGRRYRVYPEGTLELRRVT 488
Query: 428 VQDTGQYTCMVTNSAGNTTASATLNV 453
++ G YTC+ N G T + ++ V
Sbjct: 489 AEEAGLYTCVAQNLVGADTKTVSVVV 514
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.412
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,979,582
Number of Sequences: 37866
Number of extensions: 1752758
Number of successful extensions: 25821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 583
Number of HSP's successfully gapped in prelim test: 421
Number of HSP's that attempted gapping in prelim test: 13630
Number of HSP's gapped (non-prelim): 7465
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.