Search of human proteins with 27436974

Search of human proteins with 27436974

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|27436974 potassium voltage-gated channel, Shab-related
subfamily, member 2 [Homo sapiens]
         (911 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|27436974 potassium voltage-gated channel, Shab-related subfam...  1838   0.0  
gi|4826784 potassium voltage-gated channel, Shab-related subfami...  1022   0.0  
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   401   e-111
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    387   e-107
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   379   e-105
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   361   2e-99
gi|27436988 potassium voltage-gated channel, subfamily G, member...   360   3e-99
gi|20070166 potassium voltage-gated channel, subfamily F, member...   360   4e-99
gi|27436996 potassium voltage-gated channel, subfamily G, member...   347   2e-95
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]   334   3e-91
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   325   1e-88
gi|27436993 potassium voltage-gated channel, subfamily G, member...   306   6e-83
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   303   6e-82
gi|163792201 Shaw-related voltage-gated potassium channel protei...   303   6e-82
gi|19071574 potassium voltage-gated channel, subfamily G, member...   302   1e-81
gi|88758576 Shaw-related voltage-gated potassium channel protein...   297   3e-80
gi|24497462 Shaw-related voltage-gated potassium channel protein...   297   3e-80
gi|24497464 Shaw-related voltage-gated potassium channel protein...   297   3e-80
gi|21217561 Shaw-related voltage-gated potassium channel protein...   290   3e-78
gi|21217563 Shaw-related voltage-gated potassium channel protein...   290   3e-78
gi|24497458 Shaw-related voltage-gated potassium channel protein...   290   3e-78
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   288   2e-77
gi|24497460 Shaw-related voltage-gated potassium channel protein...   287   3e-77
gi|27436986 potassium voltage-gated channel, Shal-related subfam...   280   3e-75
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   280   4e-75
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   279   1e-74
gi|27436984 potassium voltage-gated channel, Shal-related subfam...   279   1e-74
gi|119395748 potassium voltage-gated channel subfamily A member ...   278   2e-74
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   274   2e-73
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   272   1e-72

>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score = 1838 bits (4760), Expect = 0.0
 Identities = 911/911 (100%), Positives = 911/911 (100%)

Query: 1   MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR 60
           MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR
Sbjct: 1   MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR 60

Query: 61  LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG 120
           LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG
Sbjct: 61  LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG 120

Query: 121 QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW 180
           QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW
Sbjct: 121 QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW 180

Query: 181 DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC 240
           DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC
Sbjct: 181 DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC 240

Query: 241 IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV 300
           IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV
Sbjct: 241 IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV 300

Query: 301 QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE 360
           QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE
Sbjct: 301 QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE 360

Query: 361 DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF 420
           DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF
Sbjct: 361 DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF 420

Query: 421 SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD 480
           SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD
Sbjct: 421 SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD 480

Query: 481 SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL 540
           SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL
Sbjct: 481 SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL 540

Query: 541 EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST 600
           EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST
Sbjct: 541 EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST 600

Query: 601 SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP 660
           SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP
Sbjct: 601 SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP 660

Query: 661 AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK 720
           AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK
Sbjct: 661 AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK 720

Query: 721 ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP 780
           ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP
Sbjct: 721 ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP 780

Query: 781 SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD 840
           SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD
Sbjct: 781 SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD 840

Query: 841 GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD 900
           GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD
Sbjct: 841 GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD 900

Query: 901 TGYCPTRETSM 911
           TGYCPTRETSM
Sbjct: 901 TGYCPTRETSM 911


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score = 1022 bits (2643), Expect = 0.0
 Identities = 577/915 (63%), Positives = 656/915 (71%), Gaps = 67/915 (7%)

Query: 6   PPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR 65
           P G+ +  SRST SLPPEP++I+RSK CSRRV++NVGGL HEVLWRTLDRLPRTRLGKLR
Sbjct: 2   PAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLR 61

Query: 66  DCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDY 125
           DCNTH+SLLEVCDDY+L++NEYFFDRHPGAFTSILNFYRTG+LHMMEEMCALSF QELDY
Sbjct: 62  DCNTHDSLLEVCDDYSLDDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDY 121

Query: 126 WGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEK 185
           WGIDEIYLESCCQARYHQKKEQMNEEL+REAET+REREGEEFDNTCC +KRKKLWDLLEK
Sbjct: 122 WGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEK 181

Query: 186 PNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFT 245
           PNSSVAAKILAI+SI+FIVLSTIALSLNTLPELQ  DEFGQ  DN QLAHVEAVCIAWFT
Sbjct: 182 PNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFT 241

Query: 246 MEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI 305
           MEYLLRFLSSP KWKFFKGPLN IDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI
Sbjct: 242 MEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRI 301

Query: 306 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKF 365
           MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDED TKF
Sbjct: 302 MRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKF 361

Query: 366 TSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK 425
            SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK
Sbjct: 362 KSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYK 421

Query: 426 EQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDN 485
           EQKRQEKAIKRREALERAKRNGSIVSMN+KDAFARS+E++D+ VEK GE+   KD   DN
Sbjct: 422 EQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGENMGKKDKVQDN 481

Query: 486 HLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYN 545
           HLSP++WKW ++ LSETSS+KSFE K Q   +K         SSSSPQHL+ Q+LE +YN
Sbjct: 482 HLSPNKWKWTKRTLSETSSSKSFETKEQGSPEK-------ARSSSSPQHLNVQQLEDMYN 534

Query: 546 EITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDS 605
           ++ KTQ  S P  + +E   + S  +EE+EME +  P   L   +TE ++DM+S SSIDS
Sbjct: 535 KMAKTQ--SQPILNTKESAAQ-SKPKEELEMESIPSPVAPLP-TRTEGVIDMRSMSSIDS 590

Query: 606 FTSCATDFTETER---SPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGPAA 662
           F SCATDF E  R   SPL             T LP       A          E G   
Sbjct: 591 FISCATDFPEATRFSHSPL-------------TSLPSKTGGSTA---------PEVGWRG 628

Query: 663 RDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFKEN 722
             G      V+   + DAS           S    +SPKSS+K +NPLK R+LKVNF E 
Sbjct: 629 ALGASGGRFVEANPSPDAS---------QHSSFFIESPKSSMKTNNPLKLRALKVNFMEG 679

Query: 723 RGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGPSK 782
                   PS   P+     D         + +   E  +  D+ +L  E S      +K
Sbjct: 680 -------DPSPLLPVLGMYHDPLRNRGSAAAAVAGLECATLLDKAVLSPESSIYTTASAK 732

Query: 783 GLSPRFPKQK---LFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPS 839
              PR P++     F F +   + + + DT D+   L    +   K   S P   + K S
Sbjct: 733 -TPPRSPEKHTAIAFNFEAGVHQ-YIDADTDDEGQLLYSVDSSPPK---SLPGSTSPKFS 787

Query: 840 DGRDPLREEGSVGSSSPQDTGHN-CRQDIYHAVSEV--KKDSSQEGCKMENHLFAPEIHS 896
            G    R E +   SSP  T     RQ+  ++   +  K  S QE CK+ENH+ +P++  
Sbjct: 788 TG---TRSEKNHFESSPLPTSPKFLRQNCIYSTEALTGKGPSGQEKCKLENHI-SPDVRV 843

Query: 897 NPGDTGYCPTRETSM 911
            PG   +  TR+ S+
Sbjct: 844 LPGGGAHGSTRDQSI 858


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  401 bits (1030), Expect = e-111
 Identities = 202/459 (44%), Positives = 299/459 (65%), Gaps = 18/459 (3%)

Query: 37  VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96
           V +NVGG    V   TL R P TRLGKL  C++ E++LE+CDDY++ + EY+FDR+P  F
Sbjct: 17  VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLF 76

Query: 97  TSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNE------ 150
             +LNFY TGKLH+MEE+C  SF QE++YWGI+E++++SCC  RY ++KE+ +E      
Sbjct: 77  RYVLNFYYTGKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQK 136

Query: 151 ------ELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIV 204
                 +   E  ++ E+E E+FD       RKK+W  +E P   ++AK++AI S+  ++
Sbjct: 137 SHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIRMENPAYCLSAKLIAISSLSVVL 196

Query: 205 LSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKG 264
            S +A+ ++++ E Q  D  G+++D   L  VE  CIAWFT E  +R  ++P + KF+K 
Sbjct: 197 ASIVAMCVHSMSEFQNED--GEVDDP-VLEGVEIACIAWFTGELAVRLAAAPCQKKFWKN 253

Query: 265 PLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSL 324
           PLN+ID ++I+P+Y T+ +    +     +N+ +VVQI R+MRI RILKLARHS GL+SL
Sbjct: 254 PLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRIFRILKLARHSVGLRSL 313

Query: 325 GFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGY 384
           G TLR SY+E+GLL+LFL++GI IFS L++  EKD+  +  TSIP  +WWATI+MTTVGY
Sbjct: 314 GATLRHSYHEVGLLLLFLSVGISIFSVLIYSVEKDDHTSSLTSIPICWWWATISMTTVGY 373

Query: 385 GDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAK 444
           GD +P TL GK++   C I G+LV+ALPI II N FS++Y++QK  +      +A E+  
Sbjct: 374 GDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYYQKQKDIDVDQCSEDAPEKCH 433

Query: 445 RNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSAD 483
               +   N++D +A+ M     ++   G   +  DS D
Sbjct: 434 ---ELPYFNIRDIYAQRMHTFITSLSSVGIVVSDPDSTD 469


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  387 bits (993), Expect = e-107
 Identities = 212/468 (45%), Positives = 311/468 (66%), Gaps = 34/468 (7%)

Query: 39  INVGGLNHEVLWRTLDRLPRTRLGKLRDCNTH----------ESLLEVCDDYNLNENEYF 88
           +NVGG    +  + L   P TRLGKL                 S LE+CDD N  +NEYF
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 89  FDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQM 148
           FDR   AF  +L++YRTG+LH+ME++CALSF QE+ YWGIDE+ ++SCC+ RY ++KE +
Sbjct: 103 FDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKE-L 161

Query: 149 NEEL-----RREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFI 203
           +E L       + E+  E E ++F    CP  R+KLW++LEKP SS AA+I  ++SI+F+
Sbjct: 162 SETLDFKKDTEDQESQHESE-QDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFV 220

Query: 204 VLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFK 263
           V+S I ++L +        E   L D + L  +E VCI+WFT E++LRFL   ++ +F +
Sbjct: 221 VVSIINMALMSA-------ELSWL-DLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLR 272

Query: 264 GPLNVIDLLAILPYYVTIFLTE--SNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGL 321
              N+IDLLAILP+Y+T+ +     +++  + +NV R+VQ+ R++R LR+LKL RHSTGL
Sbjct: 273 KVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGL 332

Query: 322 QSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTT 381
           +SLG T+ + Y E+GLL+LFL++GI IFS++ +FAE+    T FTS+P ++WWAT +MTT
Sbjct: 333 RSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTT 392

Query: 382 VGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALE 441
           VGYGDI P T  GKIV  +C ++G+LV+ALPI II + FS  Y   K +E A+++REAL+
Sbjct: 393 VGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALK 452

Query: 442 RAKRN---GSIVSMNLKDAFARS-MELIDVAVEKAGESANTKDSADDN 485
           +  +N    S +S+NL+D +ARS ME++ +   K  E A+T+ S  D+
Sbjct: 453 KLTKNIATDSYISVNLRDVYARSIMEMLRL---KGRERASTRSSGGDD 497


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  379 bits (973), Expect = e-105
 Identities = 194/472 (41%), Positives = 300/472 (63%), Gaps = 16/472 (3%)

Query: 26  DIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNEN 85
           D+  +      ++INVGG    +   TL R P TRLG+L  C++ E++LE+CDDY+  + 
Sbjct: 8   DVSEANVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQR 67

Query: 86  EYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 145
           E++FDR+P  F  +L+FY TGKLH+M E+C  SF QE++YWGI+E +++SCC   YH +K
Sbjct: 68  EFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRK 127

Query: 146 -----EQMNEELRREAETMRERE-------GEEFDNTCCPDKRKKLWDLLEKPNSSVAAK 193
                E+ +E+  +E+ T    E         +FD     + R++LW  L+ P  SV ++
Sbjct: 128 VEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSR 187

Query: 194 ILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFL 253
           + +I+SIL ++ S I + LN+LP+ Q  D  G   ++ +   VE   IAWFT E + RF 
Sbjct: 188 VFSILSILVVMGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFA 247

Query: 254 SSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILK 313
            +P+  KFFK  LN+IDL++I+P+Y+T+ +    +S     N+ RV Q+ R+MRI RILK
Sbjct: 248 VAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIFRILK 307

Query: 314 LARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFW 373
           LARHSTGL+SLG TL+ SY E+GLL+L+L++GI IFS + +  EK+E+     +IPA +W
Sbjct: 308 LARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEEN-EGLATIPACWW 366

Query: 374 WATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKA 433
           WAT++MTTVGYGD+ P T  GK+    C +AG+LV+ LPI +I N FS FY+ QK+ E A
Sbjct: 367 WATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESA 426

Query: 434 IKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKDSADDN 485
           ++  +  +  K    + S+NL+D +A  ++ +  ++     S+ ++ S +D+
Sbjct: 427 MRSCDFGDGMK---EVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLNDS 475


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  361 bits (926), Expect = 2e-99
 Identities = 193/511 (37%), Positives = 302/511 (59%), Gaps = 39/511 (7%)

Query: 6   PPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR 65
           P  L  +++ + +S  P P   IR +     +++NVGG+  ++  R L R P TRLG+L+
Sbjct: 21  PTPLGGRSTETFVSEFPGPDTGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRLQ 80

Query: 66  DCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDY 125
              + E    +CDDY+    E++FDRHPG F S+L+FYRTG LH+++E+C  +FGQE DY
Sbjct: 81  AAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFYRTGHLHVLDELCVFAFGQEADY 140

Query: 126 WGIDEIYLESCCQARYHQKKEQMNEELRREAETMR------------EREGEEFDNTCCP 173
           WG+ E  L +CC+ARY +++         +++T              +RE   +    C 
Sbjct: 141 WGLGENALAACCRARYLERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGAARCG 200

Query: 174 DKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQ------- 226
             R++LW  +E P  S+ +K+ + VSI  ++ S  A+ +++LPE Q  +           
Sbjct: 201 RLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIAAMCIHSLPEYQAREAAAAVAAVAAG 260

Query: 227 -----LNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI 281
                + D+  L  +E  CIAWF+ E   R L +P+   FF  PLN+ID++++LP+Y+T+
Sbjct: 261 RSPEGVRDDPVLRRLEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTL 320

Query: 282 F--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLI 339
              +   ++   +F ++ +VVQ+FR+MRI R+LKLARHSTGL+SLG TL+ SY E+G+L+
Sbjct: 321 LAGVALGDQGGKEFGHLGKVVQVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILL 380

Query: 340 LFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGG 399
           L+LA+G+ +FS + + AEK+ED   F +IPA +WW T++MTTVGYGD+ P T+ GK+   
Sbjct: 381 LYLAVGVSVFSGVAYTAEKEED-VGFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAAS 439

Query: 400 LCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFA 459
            C + G+LV+ALPI II N FS FY+ QK          ALE A RN +      +D  +
Sbjct: 440 GCILGGILVVALPITIIFNKFSHFYRRQK----------ALEAAVRNSN--HQEFEDLLS 487

Query: 460 RSMELIDVAVEKAGESANTKDSADDNHLSPS 490
               + + ++E + E++    SAD    +PS
Sbjct: 488 SIDGVSEASLETSRETSQEGQSADLESQAPS 518


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  360 bits (924), Expect = 3e-99
 Identities = 181/423 (42%), Positives = 277/423 (65%), Gaps = 21/423 (4%)

Query: 35  RRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPG 94
           RR+ INVGG+ + + W TLD  P TRLG+L+ C   + +L VCDDY++  NE+FFDR+PG
Sbjct: 63  RRIIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPG 122

Query: 95  AFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRR 154
           AF +IL F R GKL ++ EMCALSF +EL YWGI E +L+ CC+ RY QK E+  E + R
Sbjct: 123 AFGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVER 182

Query: 155 EAE-TMREREGEEFDNTCCPDKR-----KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208
           E E    + EG + +     + R     ++L D++E+P+S +  K+ A +S+LF+ ++ +
Sbjct: 183 EEEDDALDSEGRDSEGPAEGEGRLGRCMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAV 242

Query: 209 ALSLNTLPELQETDEFGQLNDNRQLAH----VEAVCIAWFTMEYLLRFLSSPNKWKFFKG 264
            LS++TLP L+E +E G  +   Q+ H    VE+VC+ WF++E+LLR + +P+K+ F + 
Sbjct: 243 NLSVSTLPSLREEEEQGHCS---QMCHNVFIVESVCVGWFSLEFLLRLIQAPSKFAFLRS 299

Query: 265 PLNVIDLLAILPYYVTIFL-------TESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 317
           PL +IDL+AILPYY+T+ +        +          V  V+++ R +RIL +++LARH
Sbjct: 300 PLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARH 359

Query: 318 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKD-EDATKFTSIPASFWWAT 376
           S GLQ+LG T RR   E GLL+LFL + I +F+ L++  E +  D+ +FTSIPA +WWA 
Sbjct: 360 SLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEMADSPEFTSIPACYWWAV 419

Query: 377 ITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKR 436
           ITMTTVGYGD+ P++  G++V     ++G+L++A P+  I + FS  Y E K++++ +  
Sbjct: 420 ITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLELKQEQERVMF 479

Query: 437 REA 439
           R A
Sbjct: 480 RRA 482


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  360 bits (923), Expect = 4e-99
 Identities = 188/457 (41%), Positives = 286/457 (62%), Gaps = 7/457 (1%)

Query: 22  PEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDC--NTHESLLEVCDD 79
           PEP     + +    + +NVGG+   +    L + P TRL +L +C    ++++  +CDD
Sbjct: 10  PEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDD 69

Query: 80  YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
           Y+  + E++FDR P AF  ++  Y  G++HM + +C + F  E+D+W +D  +L+ CC++
Sbjct: 70  YDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKS 129

Query: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVS 199
              +K+E++ EE+ R  + + +  G +         +K +W  LEKP SS  A+++A++S
Sbjct: 130 HLSEKREEL-EEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLS 188

Query: 200 ILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKW 259
            L I++S++ + + T+PELQ  D  G   ++  L +VE  CI WFT+EYLLR  SSPNK 
Sbjct: 189 FLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKL 248

Query: 260 KFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHST 319
            F    +N++D+LAILP+YV++ LT     +++  NV++ VQ  RIMRI RI KLARHS+
Sbjct: 249 HFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSS 308

Query: 320 GLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITM 379
           GLQ+L + L+RS+ ELGLL+++LA+GI +FS+L +  E+    T F SIP SFWWA ITM
Sbjct: 309 GLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITM 368

Query: 380 TTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREA 439
           TTVGYGDIYPKT LGK+   +  + GV+ IALPI  I+NNF  +Y +Q+  E A K    
Sbjct: 369 TTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHE-- 426

Query: 440 LERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESA 476
           LE  + N S      K   +RS +L ++  E AG+ A
Sbjct: 427 LELMELNSSSGGEG-KTGGSRS-DLDNLPPEPAGKEA 461


>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
           [Homo sapiens]
          Length = 519

 Score =  347 bits (891), Expect = 2e-95
 Identities = 187/473 (39%), Positives = 292/473 (61%), Gaps = 33/473 (6%)

Query: 8   GLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDC 67
           GL  +  R   +L   PVD+       + + INVGG  + + W TLDR P +RL KLR C
Sbjct: 38  GLYYRRVRKVGALDASPVDL------KKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLC 91

Query: 68  NTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWG 127
            ++E ++++CDDY+ +  E+FFDR P AF  I++F   GKL +++EMCALSF +EL YWG
Sbjct: 92  RSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWG 151

Query: 128 IDEIYLESCCQARYHQKKEQMNE--------ELRREAETMREREGEEFDNTCCPDKRKKL 179
           I+E +LE CC  +  +K E++ E         LR++ ET R          C      +L
Sbjct: 152 IEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLC----MNRL 207

Query: 180 WDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDN-RQLAHVEA 238
            +++E P S +  K+ A +SILF+  + ++L ++T+P+L+  ++ G+ +     +  VE 
Sbjct: 208 REMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVET 267

Query: 239 VCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTE---------SNKS 289
           +C+AWF++E+ LRF+ + +K +FF+GPLN+ID+LAI PYYV++ ++E         S  S
Sbjct: 268 ICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSS 327

Query: 290 VLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIF 349
            L  + V  V+++ R +RIL +++LARHS GLQ+LG T+RR   E GLL+LFLA+ I +F
Sbjct: 328 YL--EKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLF 385

Query: 350 SSLVFFAEKDED-ATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLV 408
           S LV+ AEK+     +FTSIPAS+WWA I+MTTVGYGD+ P+++ G++V     ++G+L+
Sbjct: 386 SPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILI 445

Query: 409 IALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARS 461
           +A P   I + FS  Y E K++++ ++ R  L   +  G      L D    S
Sbjct: 446 MAFPATSIFHTFSHSYLELKKEQEQLQAR--LRHLQNTGPASECELLDPHVAS 496


>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
          Length = 545

 Score =  334 bits (856), Expect = 3e-91
 Identities = 167/416 (40%), Positives = 266/416 (63%), Gaps = 14/416 (3%)

Query: 37  VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96
           + +NVGG ++++ +  L   P+TRLG+L    +    L +CDDY    +EYFFDR P  F
Sbjct: 99  LNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVF 158

Query: 97  TSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREA 156
             + NFY +G L +++ +C   F +EL YWG+   Y   CC+  + +++++++E L+ + 
Sbjct: 159 QLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQH 218

Query: 157 ETMREREGEEF-----DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALS 211
           E   + + EE      D      +R++LW+L+EKP SSVAAK + + S  F+++S +AL+
Sbjct: 219 ELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALA 278

Query: 212 LNTLPELQETDEFGQLNDNRQ--LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVI 269
           LNT+ E+Q+    G+   + +  L HVE +C+ +FT+EYLLR  S+P+  +F +  LN++
Sbjct: 279 LNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLV 338

Query: 270 DLLAILPYYVTIFLT-------ESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQ 322
           DL+AILP Y+ + L        +  ++V     V +V+++ R+MRI RILKLARHSTGL+
Sbjct: 339 DLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLR 398

Query: 323 SLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTV 382
           + GFTLR+ Y ++G L+LF+AMGI  FS+ V+  E D  +T FT+IP S+WWA ++++TV
Sbjct: 399 AFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTV 458

Query: 383 GYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
           GYGD+YP+T LG+    LC   G+++  +PI I+ N FS++Y + K  E    RRE
Sbjct: 459 GYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRE 514


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  325 bits (833), Expect = 1e-88
 Identities = 167/409 (40%), Positives = 257/409 (62%), Gaps = 10/409 (2%)

Query: 32  TCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDR 91
           T +R V INVGG    + W  L R P  RL +LR C  H+ LL VCDDY+++ +E+FFDR
Sbjct: 14  TRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFFFDR 73

Query: 92  HPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEE 151
            P AF +I+   R GKL ++   CAL+F  EL YWGIDE  LE CC  R  +++E+  E 
Sbjct: 74  SPCAFRAIVALLRAGKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRREEEAAE- 132

Query: 152 LRREAETMREREGEEF----DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLST 207
             R   T R  +G               R++L D+++ P+S +A K+ A VS+ F+ ++ 
Sbjct: 133 -ARAGPTERGAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKLFACVSVSFVAVTA 191

Query: 208 IALSLNTLPELQETDEFGQLNDN-RQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPL 266
           + L L+T+P+++  +E G+ +   R L  +E VC+AWF+ E+LLR L + +K  F + PL
Sbjct: 192 VGLCLSTMPDIRAEEERGECSPKCRSLFVLETVCVAWFSFEFLLRSLQAESKCAFLRAPL 251

Query: 267 NVIDLLAILPYYVTIF--LTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSL 324
           N+ID+LA+LP+YV++   L          +    V+++ R +R+L +++LARHS GL+SL
Sbjct: 252 NIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLRALRVLYVMRLARHSLGLRSL 311

Query: 325 GFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATK-FTSIPASFWWATITMTTVG 383
           G T+RR   E GLL+LFL + + +F+ LV  AE++  A + F+S+PAS+WWA I+MTTVG
Sbjct: 312 GLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELGARRDFSSVPASYWWAVISMTTVG 371

Query: 384 YGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 432
           YGD+ P++L G++V     ++G+L++A P+  I + FS  Y E K Q++
Sbjct: 372 YGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTFSRSYSELKEQQQ 420


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  306 bits (784), Expect = 6e-83
 Identities = 165/413 (39%), Positives = 244/413 (59%), Gaps = 9/413 (2%)

Query: 37  VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96
           V +NVGG  + +    L   P  R+ +L  C +   +LEVCDDY+   NEYFFDRH  AF
Sbjct: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70

Query: 97  TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQK-KEQMNEELRR 154
             IL + R  GKL     MC LSF  E+ YWG++  +LE CCQ R   +  +        
Sbjct: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130

Query: 155 EAETMREREGEEFDNTCCPDKR--KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL 212
           E   +   E         P +R  +++    E+P SS+AA+ILA VS++F+++S + L  
Sbjct: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190

Query: 213 NTLPELQETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 272
           +TLP+ +      +  D+R    +EA+CI WFT E ++RF+ S NK +F K PLN+IDLL
Sbjct: 191 STLPDWRNAAADNRSLDDRSRI-IEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLL 249

Query: 273 AILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332
           AI PYY+++ +T       Q Q     +++ R+MRI  ++KLARH  GLQ+LG TL+R Y
Sbjct: 250 AITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCY 309

Query: 333 NELGLLILFLAMGIMIFSSLVFFAEKDEDA----TKFTSIPASFWWATITMTTVGYGDIY 388
            E+ +L++F+ + + IFS+L    E   D       FTSIPA+ WW  I+MTTVGYGD+Y
Sbjct: 310 REMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIISMTTVGYGDMY 369

Query: 389 PKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALE 441
           P T+ G+I+GG+C ++G++++ALPI  I ++F + Y E K +     R  + E
Sbjct: 370 PITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSLSTE 422


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  303 bits (775), Expect = 6e-82
 Identities = 174/466 (37%), Positives = 250/466 (53%), Gaps = 76/466 (16%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHP 93
           S R+ INVGG  H+    TL  LP TRL  L + + H        DY+   +E+FFDRHP
Sbjct: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61

Query: 94  GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELR 153
           G F  ILN+YRTGKLH   ++C   + +EL +WGIDE  +E CC   Y Q ++       
Sbjct: 62  GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDA------ 115

Query: 154 REAETMREREGEEFDNTC----------------------------CPDKRK-------- 177
              E +    G   DN+                              PD R         
Sbjct: 116 --EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQ 173

Query: 178 -KLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPELQETDEFGQL 227
            ++W L E P SS  A+ +A  S+ FI++S     L T           E++      Q+
Sbjct: 174 PRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQV 233

Query: 228 NDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI 281
              R+      L ++E VC+ WFT E+L+R +  PNK +F K  LN+ID +AILP+Y+ +
Sbjct: 234 RYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEV 293

Query: 282 FLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILF 341
            L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S NE  LLI+F
Sbjct: 294 GL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF 351

Query: 342 LAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392
           LA+G++IF++++++AE+           + T F +IP  FWWA +TMTT+GYGD+YP+T 
Sbjct: 352 LALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTW 411

Query: 393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
            G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+++
Sbjct: 412 SGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  303 bits (775), Expect = 6e-82
 Identities = 174/466 (37%), Positives = 250/466 (53%), Gaps = 76/466 (16%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHP 93
           S R+ INVGG  H+    TL  LP TRL  L + + H        DY+   +E+FFDRHP
Sbjct: 7   SERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHF-----DYDPRADEFFFDRHP 61

Query: 94  GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELR 153
           G F  ILN+YRTGKLH   ++C   + +EL +WGIDE  +E CC   Y Q ++       
Sbjct: 62  GVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDA------ 115

Query: 154 REAETMREREGEEFDNTC----------------------------CPDKRK-------- 177
              E +    G   DN+                              PD R         
Sbjct: 116 --EEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQ 173

Query: 178 -KLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPELQETDEFGQL 227
            ++W L E P SS  A+ +A  S+ FI++S     L T           E++      Q+
Sbjct: 174 PRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQV 233

Query: 228 NDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI 281
              R+      L ++E VC+ WFT E+L+R +  PNK +F K  LN+ID +AILP+Y+ +
Sbjct: 234 RYYREAETEAFLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEV 293

Query: 282 FLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILF 341
            L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S NE  LLI+F
Sbjct: 294 GL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIF 351

Query: 342 LAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVGYGDIYPKTL 392
           LA+G++IF++++++AE+           + T F +IP  FWWA +TMTT+GYGD+YP+T 
Sbjct: 352 LALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTW 411

Query: 393 LGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
            G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+++
Sbjct: 412 SGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKK 457


>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  302 bits (773), Expect = 1e-81
 Identities = 165/423 (39%), Positives = 244/423 (57%), Gaps = 18/423 (4%)

Query: 37  VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96
           V +NVGG  + +    L   P  R+ +L  C +   +LEVCDDY+   NEYFFDRH  AF
Sbjct: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70

Query: 97  TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQK-KEQMNEELRR 154
             IL + R  GKL     MC LSF  E+ YWG++  +LE CCQ R   +  +        
Sbjct: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130

Query: 155 EAETMREREGEEFDNTCCPDKR--KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL 212
           E   +   E         P +R  +++    E+P SS+AA+ILA VS++F+++S + L  
Sbjct: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190

Query: 213 NTLPELQETDEFGQLNDNRQLAH----------VEAVCIAWFTMEYLLRFLSSPNKWKFF 262
           +TLP+ +      +  D+R              +EA+CI WFT E ++RF+ S NK +F 
Sbjct: 191 STLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFV 250

Query: 263 KGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQ 322
           K PLN+IDLLAI PYY+++ +T       Q Q     +++ R+MRI  ++KLARH  GLQ
Sbjct: 251 KRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQ 310

Query: 323 SLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDA----TKFTSIPASFWWATIT 378
           +LG TL+R Y E+ +L++F+ + + IFS+L    E   D       FTSIPA+ WW  I+
Sbjct: 311 TLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIIS 370

Query: 379 MTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
           MTTVGYGD+YP T+ G+I+GG+C ++G++++ALPI  I ++F + Y E K +     R  
Sbjct: 371 MTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSL 430

Query: 439 ALE 441
           + E
Sbjct: 431 STE 433


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  297 bits (761), Expect = 3e-80
 Identities = 177/475 (37%), Positives = 253/475 (53%), Gaps = 68/475 (14%)

Query: 30  SKTC----------SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN------THESL 73
           SKTC          S ++ INVGG  HE    TL  LP TRL  L D +      T    
Sbjct: 21  SKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGG 80

Query: 74  LEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYL 133
           +           E+FFDRHPG F  +LN+YRTGKLH   ++C   F +EL +WGIDE  +
Sbjct: 81  VGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDV 140

Query: 134 ESCCQARYHQKKEQ-------------------MNEELRREAETMRER-------EGEEF 167
           E CC   Y Q ++                     +E    E E   +R        G   
Sbjct: 141 EPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGA 200

Query: 168 DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPEL 218
            +  C   + ++W L E P SS AA+++A  S+ FI++S     L T         + E+
Sbjct: 201 GSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEI 260

Query: 219 QETDEFGQLNDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 272
                   ++  R+      L ++E VC+ WFT+E+L+R +  P+   F K  LN+ID +
Sbjct: 261 LRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFV 320

Query: 273 AILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332
           AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S 
Sbjct: 321 AILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 378

Query: 333 NELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVG 383
           NE  LLI+FLA+G++IF++++++AE+           D T F +IP  FWWA +TMTT+G
Sbjct: 379 NEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLG 438

Query: 384 YGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
           YGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+R+
Sbjct: 439 YGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK 493


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  297 bits (761), Expect = 3e-80
 Identities = 177/475 (37%), Positives = 253/475 (53%), Gaps = 68/475 (14%)

Query: 30  SKTC----------SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN------THESL 73
           SKTC          S ++ INVGG  HE    TL  LP TRL  L D +      T    
Sbjct: 21  SKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGG 80

Query: 74  LEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYL 133
           +           E+FFDRHPG F  +LN+YRTGKLH   ++C   F +EL +WGIDE  +
Sbjct: 81  VGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDV 140

Query: 134 ESCCQARYHQKKEQ-------------------MNEELRREAETMRER-------EGEEF 167
           E CC   Y Q ++                     +E    E E   +R        G   
Sbjct: 141 EPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGA 200

Query: 168 DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPEL 218
            +  C   + ++W L E P SS AA+++A  S+ FI++S     L T         + E+
Sbjct: 201 GSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEI 260

Query: 219 QETDEFGQLNDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 272
                   ++  R+      L ++E VC+ WFT+E+L+R +  P+   F K  LN+ID +
Sbjct: 261 LRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFV 320

Query: 273 AILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332
           AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S 
Sbjct: 321 AILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 378

Query: 333 NELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVG 383
           NE  LLI+FLA+G++IF++++++AE+           D T F +IP  FWWA +TMTT+G
Sbjct: 379 NEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLG 438

Query: 384 YGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
           YGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+R+
Sbjct: 439 YGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK 493


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  297 bits (761), Expect = 3e-80
 Identities = 177/475 (37%), Positives = 253/475 (53%), Gaps = 68/475 (14%)

Query: 30  SKTC----------SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN------THESL 73
           SKTC          S ++ INVGG  HE    TL  LP TRL  L D +      T    
Sbjct: 21  SKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGG 80

Query: 74  LEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYL 133
           +           E+FFDRHPG F  +LN+YRTGKLH   ++C   F +EL +WGIDE  +
Sbjct: 81  VGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDV 140

Query: 134 ESCCQARYHQKKEQ-------------------MNEELRREAETMRER-------EGEEF 167
           E CC   Y Q ++                     +E    E E   +R        G   
Sbjct: 141 EPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGA 200

Query: 168 DNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------LPEL 218
            +  C   + ++W L E P SS AA+++A  S+ FI++S     L T         + E+
Sbjct: 201 GSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEI 260

Query: 219 QETDEFGQLNDNRQ------LAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLL 272
                   ++  R+      L ++E VC+ WFT+E+L+R +  P+   F K  LN+ID +
Sbjct: 261 LRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFV 320

Query: 273 AILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSY 332
           AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG TLR S 
Sbjct: 321 AILPFYLEVGL--SGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRAST 378

Query: 333 NELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATITMTTVG 383
           NE  LLI+FLA+G++IF++++++AE+           D T F +IP  FWWA +TMTT+G
Sbjct: 379 NEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLG 438

Query: 384 YGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438
           YGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K+R+
Sbjct: 439 YGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRK 493


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  290 bits (743), Expect = 3e-78
 Identities = 181/492 (36%), Positives = 253/492 (51%), Gaps = 91/492 (18%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNT------------------ 69
           + RV +NVGG  HE    TL  LP TRL  L       DC T                  
Sbjct: 7   NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66

Query: 70  -----------HESLLEVCD-------DYNLNENEYFFDRHPGAFTSILNFYRTGKLHMM 111
                       E     C        D+     E+FFDRHPG F  +LN+YRTGKLH  
Sbjct: 67  APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126

Query: 112 EEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTC 171
            ++C   F +EL +WGIDE  +E CC   Y Q ++   EE     ET     G+  D+  
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184

Query: 172 CPDKR-----------------------KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208
              KR                        ++W L E P SS AA+ +A  S+ FI++S  
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244

Query: 209 ALSLNTL-----------PELQETDEFGQ--LNDNRQLAHVEAVCIAWFTMEYLLRFLSS 255
              L T            P +  T    Q  +  +  L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304

Query: 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315
           PNK +F K  LN+ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL 
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFT 366
           RH  GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           + T+F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 426
           +IP  FWWA +TMTT+GYGD+YP+T  G +VG LC +AGVL IA+P+P+IVNNF  +Y  
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482

Query: 427 QKRQEKAIKRRE 438
              ++K  ++R+
Sbjct: 483 AMAKQKLPRKRK 494


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  290 bits (743), Expect = 3e-78
 Identities = 181/492 (36%), Positives = 253/492 (51%), Gaps = 91/492 (18%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNT------------------ 69
           + RV +NVGG  HE    TL  LP TRL  L       DC T                  
Sbjct: 7   NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66

Query: 70  -----------HESLLEVCD-------DYNLNENEYFFDRHPGAFTSILNFYRTGKLHMM 111
                       E     C        D+     E+FFDRHPG F  +LN+YRTGKLH  
Sbjct: 67  APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126

Query: 112 EEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTC 171
            ++C   F +EL +WGIDE  +E CC   Y Q ++   EE     ET     G+  D+  
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184

Query: 172 CPDKR-----------------------KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208
              KR                        ++W L E P SS AA+ +A  S+ FI++S  
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244

Query: 209 ALSLNTL-----------PELQETDEFGQ--LNDNRQLAHVEAVCIAWFTMEYLLRFLSS 255
              L T            P +  T    Q  +  +  L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304

Query: 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315
           PNK +F K  LN+ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL 
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFT 366
           RH  GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           + T+F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 426
           +IP  FWWA +TMTT+GYGD+YP+T  G +VG LC +AGVL IA+P+P+IVNNF  +Y  
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482

Query: 427 QKRQEKAIKRRE 438
              ++K  ++R+
Sbjct: 483 AMAKQKLPRKRK 494


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  290 bits (743), Expect = 3e-78
 Identities = 181/492 (36%), Positives = 253/492 (51%), Gaps = 91/492 (18%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLR------DCNT------------------ 69
           + RV +NVGG  HE    TL  LP TRL  L       DC T                  
Sbjct: 7   NERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPR 66

Query: 70  -----------HESLLEVCD-------DYNLNENEYFFDRHPGAFTSILNFYRTGKLHMM 111
                       E     C        D+     E+FFDRHPG F  +LN+YRTGKLH  
Sbjct: 67  APPLSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCP 126

Query: 112 EEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTC 171
            ++C   F +EL +WGIDE  +E CC   Y Q ++   EE     ET     G+  D+  
Sbjct: 127 ADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDA--EEALDIFETPDLIGGDPGDDED 184

Query: 172 CPDKR-----------------------KKLWDLLEKPNSSVAAKILAIVSILFIVLSTI 208
              KR                        ++W L E P SS AA+ +A  S+ FI++S  
Sbjct: 185 LAAKRLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSIT 244

Query: 209 ALSLNTL-----------PELQETDEFGQ--LNDNRQLAHVEAVCIAWFTMEYLLRFLSS 255
              L T            P +  T    Q  +  +  L +VE VC+ WFT E+L+R + S
Sbjct: 245 TFCLETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFS 304

Query: 256 PNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLA 315
           PNK +F K  LN+ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL 
Sbjct: 305 PNKLEFIKNLLNIIDFVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 316 RHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFT 366
           RH  GL+ LG TLR S NE  LLI+FLA+G++IF++++++AE+           + T+F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 367 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 426
           +IP  FWWA +TMTT+GYGD+YP+T  G +VG LC +AGVL IA+P+P+IVNNF  +Y  
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSL 482

Query: 427 QKRQEKAIKRRE 438
              ++K  ++R+
Sbjct: 483 AMAKQKLPRKRK 494


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  288 bits (737), Expect = 2e-77
 Identities = 184/530 (34%), Positives = 280/530 (52%), Gaps = 47/530 (8%)

Query: 22  PEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYN 81
           P P    R +T    + +NV G   +    TL+R P T LG            E    Y+
Sbjct: 28  PAPPRQERKRTQDALIVLNVSGTRFQTWQDTLERYPDTLLGSS----------ERDFFYH 77

Query: 82  LNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARY 141
               +YFFDR P  F  ILNFYRTGKLH     C  ++ +EL ++G+    +  CC   Y
Sbjct: 78  PETQQYFFDRDPDIFRHILNFYRTGKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEY 137

Query: 142 HQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSIL 201
             ++ +  E L+ +A+T  +  GE    T     R+++W   E P++S  A +   V+  
Sbjct: 138 KDRRRENAERLQDDADT--DTAGESALPTMTA--RQRVWRAFENPHTSTMALVFYYVTGF 193

Query: 202 FIVLSTIALSLNTLPELQETDEFGQLNDNRQLAH----VEAVCIAWFTMEYLLRFLSSPN 257
           FI +S IA  + T+P         +L    + A     ++  C+  FT+EYLLR  ++P+
Sbjct: 194 FIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPS 253

Query: 258 KWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARH 317
           +++F +  +++ID++AILPYY+ + +T++       ++V       R+ R+ RI K +RH
Sbjct: 254 RYRFVRSVMSIIDVVAILPYYIGLVMTDN-------EDVSGAFVTLRVFRVFRIFKFSRH 306

Query: 318 STGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATI 377
           S GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK   A+KFTSIPA+FW+  +
Sbjct: 307 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPAAFWYTIV 366

Query: 378 TMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK---AI 434
           TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K     
Sbjct: 367 TMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQK 426

Query: 435 KRREALERAKRNGSIVSM------NLKDAFARSMELIDVAVEKAGESANTKDSADDNHLS 488
           K R A  RA ++GS  +        L     +S E     V K+G S  T+     +HL 
Sbjct: 427 KARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQ----HHHLL 482

Query: 489 PSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQ 538
               K       E    + FE    EV+       +N  SS SP   S Q
Sbjct: 483 HCLEKTTN---HEFVDEQVFEESCMEVA------TVNRPSSHSPSLSSQQ 523


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  287 bits (735), Expect = 3e-77
 Identities = 172/480 (35%), Positives = 246/480 (51%), Gaps = 83/480 (17%)

Query: 34  SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHP 93
           S ++ INVGG+ HE    TL  LP TRL  L +            DY+   +E+FFDRHP
Sbjct: 87  SGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-----DYDPGADEFFFDRHP 141

Query: 94  GAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARY--HQKKEQMNEE 151
           G F  +LN+YRTGKLH   ++C   F +EL +WGIDE  +E+CC   Y  H+  E+  + 
Sbjct: 142 GVFAYVLNYYRTGKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDS 201

Query: 152 LRREAETMR-------------------------EREGEEFDNTCCPDK----------- 175
                                             +  G E    C  D            
Sbjct: 202 FEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPPGGA 261

Query: 176 -----------RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNT---------- 214
                      + ++W L E P SS AA+ +A  S+ FI++S     L T          
Sbjct: 262 GGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFIHISNK 321

Query: 215 -------LPELQ-ETDEFGQLNDNRQLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPL 266
                  +P    E     ++     L +VE VC+ WFT E+L+R    P+K +F K  L
Sbjct: 322 TVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKVEFLKSSL 381

Query: 267 NVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGF 326
           N+ID +AILP+Y+ + L  S  S    ++V   +++ R +RILRI KL RH  GL+ LG 
Sbjct: 382 NIIDCVAILPFYLEVGL--SGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGH 439

Query: 327 TLRRSYNELGLLILFLAMGIMIFSSLVFFAEK---------DEDATKFTSIPASFWWATI 377
           TLR S NE  LLI+FLA+G++IF++++++AE+           + T F +IP  FWWA +
Sbjct: 440 TLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVV 499

Query: 378 TMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRR 437
           TMTT+GYGD+YPKT  G +VG LC +AGVL IA+P+P+IVNNF  +Y     ++K  K++
Sbjct: 500 TMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKK 559


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score =  280 bits (717), Expect = 3e-75
 Identities = 176/530 (33%), Positives = 281/530 (53%), Gaps = 58/530 (10%)

Query: 20  LPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDD 79
           +P  P D  ++K     + +NV G   +    TL+R P T LG     +T +        
Sbjct: 27  MPLAPAD--KNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF----- 74

Query: 80  YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
           +N +  EYFFDR P  F  +LNFYRTGKLH     C  ++  EL ++GI    +  CC  
Sbjct: 75  FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYE 134

Query: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDK--RKKLWDLLEKPNSSVAAKILAI 197
            Y  +K       R  AE + +    E +    P    R+ +W   E P++S  A +   
Sbjct: 135 EYKDRK-------RENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYY 187

Query: 198 VSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAH----------VEAVCIAWFTME 247
           V+  FI +S I   + T+P        G +  +++L            ++  C+  FT+E
Sbjct: 188 VTGFFIAVSVITNVVETVP-------CGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE 240

Query: 248 YLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMR 307
           YLLR  ++P++++F +  +++ID++AI+PYY+ + +T +       ++V       R+ R
Sbjct: 241 YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNN-------EDVSGAFVTLRVFR 293

Query: 308 ILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTS 367
           + RI K +RHS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK   A+KFTS
Sbjct: 294 VFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTS 353

Query: 368 IPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQ 427
           IPASFW+  +TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + 
Sbjct: 354 IPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQN 413

Query: 428 KRQEK---AIKRREALERAKRNGSIVSMNLKDAFARSME--LIDVAVEKAGESANTKDSA 482
           +R +K     K R A  R  + GS       +A+  S    L++ A+E  G +   +   
Sbjct: 414 QRADKRRAQKKARLARIRVAKTGS------SNAYLHSKRNGLLNEALELTG-TPEEEHMG 466

Query: 483 DDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSP 532
               L  S+       L +T++++  + +  E +  +S  Q N  S+ SP
Sbjct: 467 KTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQ-NYPSTRSP 515


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  280 bits (716), Expect = 4e-75
 Identities = 179/460 (38%), Positives = 252/460 (54%), Gaps = 61/460 (13%)

Query: 21  PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDY 80
           PP P  ++ ++  ++RV IN+ GL  E   RTL + P T LG        E  ++  D  
Sbjct: 73  PPGPEPVVLNEG-NQRVIINIAGLRFETQLRTLSQFPETLLGD------REKRMQFFDSM 125

Query: 81  NLNENEYFFDRHPGAFTSILNFYRTG-KLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
               NEYFFDR+  +F  IL +Y++G K+     +    F  E+ ++             
Sbjct: 126 R---NEYFFDRNRPSFDGILYYYQSGGKIRRPANVPIDIFADEISFY------------- 169

Query: 140 RYHQKKEQMNEELRREA-ETMREREGEEFD-NTCCP--DKRKKLWDLLEKPNSSVAAKIL 195
                      EL  EA +  RE EG   D  T  P  D  ++ W L E P SS AA+ +
Sbjct: 170 -----------ELGSEAMDQFREDEGFIKDPETLLPTNDIHRQFWLLFEYPESSSAARAV 218

Query: 196 AIVSILFIVLSTIALSLNTLPELQETDEFGQLND-NRQLAH--------------VEAVC 240
           A+VS+L +V+S     L TLPE +E  E   + D N  ++               VE+ C
Sbjct: 219 AVVSVLVVVISITIFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTC 278

Query: 241 IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIF--LTESNKSVLQFQNVRR 298
           I WFT E +LRF+  P+K  FF+  +N+ID+++I+PY+ T+   L +  +   Q      
Sbjct: 279 IVWFTFELVLRFVVCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLA 338

Query: 299 VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK 358
           +++I R++R+ RI KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+FAE 
Sbjct: 339 ILRIIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEV 398

Query: 359 DEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVN 418
           DE  + F+SIP  FWWA +TMTTVGYGD+ P T  GKIVG LC IAGVL IALP+P+IV+
Sbjct: 399 DEPESHFSSIPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVS 458

Query: 419 NFSEFYKEQKRQEKAIKRREALER-----AKRNGSIVSMN 453
           NF+ FY  +   E+       +ER       R GS  S+N
Sbjct: 459 NFNYFYHRETENEEKQNIPGEIERILNSVGSRMGSTDSLN 498


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  279 bits (713), Expect = 1e-74
 Identities = 151/418 (36%), Positives = 239/418 (57%), Gaps = 26/418 (6%)

Query: 20  LPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDD 79
           LPP P   +++      + +NV G   E    TLDR P T LG     ++ +        
Sbjct: 27  LPPAPG--VKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLG-----SSEKEFF----- 74

Query: 80  YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
           Y+ +  EYFFDR P  F  +LNFYRTG+LH   + C  +F +EL ++G+    +  CC  
Sbjct: 75  YDADSGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLE 134

Query: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVS 199
            Y  +K++  E L  + E  +  +G           R++LW   E P++S AA +   V+
Sbjct: 135 EYRDRKKENAERLAEDEEAEQAGDGPALP--AGSSLRQRLWRAFENPHTSTAALVFYYVT 192

Query: 200 ILFIVLSTIALSLNTLP---ELQETDEFGQLNDNRQLAH--VEAVCIAWFTMEYLLRFLS 254
             FI +S IA  + T+P     + +       +    A   ++  C+  FT EYLLR  +
Sbjct: 193 GFFIAVSVIANVVETIPCRGSARRSSREQPCGERFPQAFFCMDTACVLIFTGEYLLRLFA 252

Query: 255 SPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKL 314
           +P++ +F +  +++ID++AILPYY+ + + +++       +V       R+ R+ RI K 
Sbjct: 253 APSRCRFLRSVMSLIDVVAILPYYIGLLVPKND-------DVSGAFVTLRVFRVFRIFKF 305

Query: 315 ARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWW 374
           +RHS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK  + T FTSIPA+FW+
Sbjct: 306 SRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTNKTNFTSIPAAFWY 365

Query: 375 ATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEK 432
             +TMTT+GYGD+ P T+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + +R +K
Sbjct: 366 TIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADK 423


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score =  279 bits (713), Expect = 1e-74
 Identities = 154/432 (35%), Positives = 243/432 (56%), Gaps = 45/432 (10%)

Query: 20  LPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDD 79
           +P  P D  ++K     + +NV G   +    TL+R P T LG     +T +        
Sbjct: 27  MPLAPAD--KNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLG-----STEKEFF----- 74

Query: 80  YNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
           +N +  EYFFDR P  F  +LNFYRTGKLH     C  ++  EL ++GI    +  CC  
Sbjct: 75  FNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYE 134

Query: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDK--RKKLWDLLEKPNSSVAAKILAI 197
            Y  +K       R  AE + +    E +    P    R+ +W   E P++S  A +   
Sbjct: 135 EYKDRK-------RENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYY 187

Query: 198 VSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAH----------VEAVCIAWFTME 247
           V+  FI +S I   + T+P        G +  +++L            ++  C+  FT+E
Sbjct: 188 VTGFFIAVSVITNVVETVP-------CGTVPGSKELPCGERYSVAFFCLDTACVMIFTVE 240

Query: 248 YLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMR 307
           YLLR  ++P++++F +  +++ID++AI+PYY+ + +T +       ++V       R+ R
Sbjct: 241 YLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNN-------EDVSGAFVTLRVFR 293

Query: 308 ILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTS 367
           + RI K +RHS GL+ LG+TL+   +ELG L+  L M I+IF++++F+AEK   A+KFTS
Sbjct: 294 VFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTS 353

Query: 368 IPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQ 427
           IPASFW+  +TMTT+GYGD+ PKT+ GKI G +C ++GVLVIALP+P+IV+NFS  Y + 
Sbjct: 354 IPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQN 413

Query: 428 KRQEKAIKRREA 439
           +R +K   +++A
Sbjct: 414 QRADKRRAQKKA 425


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  278 bits (711), Expect = 2e-74
 Identities = 165/423 (39%), Positives = 254/423 (60%), Gaps = 54/423 (12%)

Query: 33  CSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRH 92
           C  RV IN+ GL  E   +TL + P T LG  +    +   L          NEYFFDR+
Sbjct: 35  CCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLR---------NEYFFDRN 85

Query: 93  PGAFTSILNFYRTG-KLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEE 151
             +F +IL +Y++G +L     +    F +E+                ++++  E+  E+
Sbjct: 86  RPSFDAILYYYQSGGRLRRPVNVPLDMFSEEI----------------KFYELGEEAMEK 129

Query: 152 LRREAETMREREGEEFDNTCCPDK--RKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIA 209
            R +   ++E E         P+K  ++++W L E P SS  A+++AIVS++ I++S + 
Sbjct: 130 FREDEGFIKEEERP------LPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVI 183

Query: 210 LSLNTLPELQETDEF-GQLN--DNRQLAH-----------VEAVCIAWFTMEYLLRFLSS 255
             L TLPEL++  +F G ++  DN  + +           VE +CI WF+ E ++RF + 
Sbjct: 184 FCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFAC 243

Query: 256 PNKWKFFKGPLNVIDLLAILPYYVT----IFLTESNKSVLQFQNVRRVVQIFRIMRILRI 311
           P+K  FFK  +N ID++AI+PY++T    I   E N+   Q  ++  ++++ R++R+ RI
Sbjct: 244 PSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLA-ILRVIRLVRVFRI 302

Query: 312 LKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPAS 371
            KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+FAE +E  + F+SIP +
Sbjct: 303 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDA 362

Query: 372 FWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFY-KEQKRQ 430
           FWWA ++MTTVGYGD+YP T+ GKIVG LC IAGVL IALP+P+IV+NF+ FY +E + +
Sbjct: 363 FWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGE 422

Query: 431 EKA 433
           E+A
Sbjct: 423 EQA 425


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  274 bits (701), Expect = 2e-73
 Identities = 167/434 (38%), Positives = 241/434 (55%), Gaps = 56/434 (12%)

Query: 28  IRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEY 87
           +R   C  RV INV GL  E   +TL + P T LG       +   L          NEY
Sbjct: 169 VRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLR---------NEY 219

Query: 88  FFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQ 147
           FFDR+  +F +IL +Y++G    ++    + F          +I+ E   + +++Q  E+
Sbjct: 220 FFDRNRPSFDAILYYYQSGG--RLKRPVNVPF----------DIFTE---EVKFYQLGEE 264

Query: 148 MNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVSILFIVLST 207
              + R +   +RE E          + +K++W L E P SS  A+ +AIVS+L I++S 
Sbjct: 265 ALLKFREDEGFVREEEDRALPEN---EFKKQIWLLFEYPESSSPARGIAIVSVLVILISI 321

Query: 208 IALSLNTLPELQETDEF----------GQLND--------------NRQLAHVEAVCIAW 243
           +   L TLPE ++  +           G LND              N     VE VCI W
Sbjct: 322 VIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVW 381

Query: 244 FTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTI---FLTESNKSVLQFQNVRR-- 298
           F+ E+++R  + P++  FFK  +N+ID+++ILPY++T+      +      Q Q      
Sbjct: 382 FSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFA 441

Query: 299 VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK 358
           +++I R++R+ RI KL+RHS GLQ LG TLR S  ELGLLI FL +G+++FSS V+FAE 
Sbjct: 442 ILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEA 501

Query: 359 DEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVN 418
           DE  T F SIP +FWWA +TMTTVGYGD+ P T+ GKIVG LC IAGVL IALP+P+IV+
Sbjct: 502 DEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVS 561

Query: 419 NFSEFYKEQKRQEK 432
           NF+ FY  +   E+
Sbjct: 562 NFNYFYHRETENEE 575


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  272 bits (695), Expect = 1e-72
 Identities = 164/440 (37%), Positives = 251/440 (57%), Gaps = 58/440 (13%)

Query: 21  PPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDY 80
           P +  D      C  RV IN+ GL  E   +TL + P T LG  +    +   L      
Sbjct: 19  PQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLR----- 73

Query: 81  NLNENEYFFDRHPGAFTSILNFYRTG-KLHMMEEMCALSFGQELDYWGIDEIYLESCCQA 139
               NEYFFDR+  +F +IL +Y++G +L     +    F +E+                
Sbjct: 74  ----NEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEI---------------- 113

Query: 140 RYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLWDLLEKPNSSVAAKILAIVS 199
           R+++  E+  E  R +   ++E E    +N    + ++++W L E P SS  A+I+AIVS
Sbjct: 114 RFYELGEEAMEMFREDEGYIKEEERPLPEN----EFQRQVWLLFEYPESSGPARIIAIVS 169

Query: 200 ILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAH---------------------VEA 238
           ++ I++S ++  L TLP  ++ +E   ++ +    H                     VE 
Sbjct: 170 VMVILISIVSFCLETLPIFRDENE--DMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVET 227

Query: 239 VCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIF--LTESNKSVLQFQNV 296
           +CI WF+ E+L+RF + P+K  FF   +N+ID++AI+PY++T+   L E  +   Q Q  
Sbjct: 228 LCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQA 287

Query: 297 RR--VVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVF 354
               ++++ R++R+ RI KL+RHS GLQ LG TL+ S  ELGLLI FL +G+++FSS V+
Sbjct: 288 MSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVY 347

Query: 355 FAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIP 414
           FAE DE  ++F SIP +FWWA ++MTTVGYGD+ P T+ GKIVG LC IAGVL IALP+P
Sbjct: 348 FAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVP 407

Query: 415 IIVNNFSEFY-KEQKRQEKA 433
           +IV+NF+ FY +E + +E+A
Sbjct: 408 VIVSNFNYFYHRETEGEEQA 427


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.132    0.387 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,506,421
Number of Sequences: 37866
Number of extensions: 1842177
Number of successful extensions: 8920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 189
Number of HSP's that attempted gapping in prelim test: 8044
Number of HSP's gapped (non-prelim): 807
length of query: 911
length of database: 18,247,518
effective HSP length: 111
effective length of query: 800
effective length of database: 14,044,392
effective search space: 11235513600
effective search space used: 11235513600
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.