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Search of human proteins with 25777724
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 1040 0.0
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 944 0.0
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 849 0.0
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 759 0.0
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 747 0.0
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 709 0.0
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 706 0.0
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 471 e-133
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 470 e-132
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 345 4e-95
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 332 7e-91
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 274 2e-73
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 265 1e-70
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 265 1e-70
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 217 2e-56
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 215 7e-56
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 181 2e-45
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 148 1e-35
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 148 1e-35
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 148 1e-35
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 145 9e-35
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 145 9e-35
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 145 9e-35
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 140 3e-33
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 133 4e-31
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 133 4e-31
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 127 2e-29
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 127 2e-29
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 122 6e-28
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 1040 bits (2688), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
Sbjct: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
Query: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
Sbjct: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
Query: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
Sbjct: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
Query: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP 240
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP
Sbjct: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP 240
Query: 241 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 300
GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
Sbjct: 241 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 300
Query: 301 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 360
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
Sbjct: 301 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 360
Query: 361 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 420
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
Sbjct: 361 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 420
Query: 421 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 480
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
Sbjct: 421 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 480
Query: 481 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Sbjct: 481 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 944 bits (2441), Expect = 0.0
Identities = 480/518 (92%), Positives = 480/518 (92%), Gaps = 38/518 (7%)
Query: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP
Sbjct: 1 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP 60
Query: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL
Sbjct: 61 ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL 120
Query: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC
Sbjct: 121 ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC 180
Query: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP 240
GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE
Sbjct: 181 GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------ 228
Query: 241 GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 300
VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD
Sbjct: 229 --------------------------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD 262
Query: 301 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 360
LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG
Sbjct: 263 LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG 322
Query: 361 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 420
PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG
Sbjct: 323 PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG 382
Query: 421 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 480
PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ
Sbjct: 383 PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ 442
Query: 481 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 518
SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
Sbjct: 443 SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS 480
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 849 bits (2193), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 97 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 156
MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK
Sbjct: 1 MDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADK 60
Query: 157 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP
Sbjct: 61 IHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 120
Query: 217 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276
LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
Sbjct: 121 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 180
Query: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF
Sbjct: 181 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 240
Query: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG
Sbjct: 241 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 300
Query: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 456
FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK
Sbjct: 301 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 360
Query: 457 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 516
ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK
Sbjct: 361 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQK 420
Query: 517 NS 518
NS
Sbjct: 421 NS 422
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 759 bits (1959), Expect = 0.0
Identities = 361/493 (73%), Positives = 431/493 (87%)
Query: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
LP +L+I+YTKIFINNEW +S SG+ FPV+NPAT E++C+V+E DK D+DKAV+AAR
Sbjct: 9 LPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAAR 68
Query: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
AF +GS WR MDASERGRLL KLADL+ERDR +LATMES+NGGK + A+ DL G IK
Sbjct: 69 QAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIK 128
Query: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
T RY AGWADKI G TIP+DG++FT+TRHEPIGVCGQIIPWNFPL+M WKI PAL CGN
Sbjct: 129 TLRYCAGWADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGN 188
Query: 206 TVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGST 265
TVV+KPAEQTPL+AL++ +LIKEAGFPPGV+NI+PGYGPTAGAAI+SH+ IDK+AFTGST
Sbjct: 189 TVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGST 248
Query: 266 EVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 325
EVGKLI+EAAG+SNLKRVTLELGGKSP I+ ADADLD AVE AH GVF++QGQCC A SR
Sbjct: 249 EVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASR 308
Query: 326 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 385
IFVEESIY+EFVRRSVERAK+ ++G+P P QGPQIDK+QY+KIL+LI+SG EGAKL
Sbjct: 309 IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL 368
Query: 386 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 445
ECGG G KG+F++PTVFSNVTD+MRIAKEEIFGPVQ+I++FK++D+VI+RANN+ +GL
Sbjct: 369 ECGGGPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGL 428
Query: 446 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 505
A VFT DI+KA+T+SSA+QAGTVW+NCY ++AQ PFGGFKMSGNGRE+GE+G EY+E
Sbjct: 429 SAGVFTKDIDKAITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTE 488
Query: 506 VKTVTVKIPQKNS 518
VKTVTVKI QKNS
Sbjct: 489 VKTVTVKISQKNS 501
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 747 bits (1928), Expect = 0.0
Identities = 354/492 (71%), Positives = 424/492 (86%)
Query: 26 LPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAAR 85
LP P NLE+K+TKIFINNEW S+SG+ F NP+T EQ+CEV+E DK D+DKAV+AA+
Sbjct: 20 LPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQ 79
Query: 86 LAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIK 145
+AF GS WRR+DA RGRLL +LADLVERDRA LA +E+++ GKPFL AF++DL+G I+
Sbjct: 80 VAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIR 139
Query: 146 TFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGN 205
T RY+AGWADKI G TIP D + FTRHEPIGVCG I PWNFPLLM WK+APALCCGN
Sbjct: 140 TLRYFAGWADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGN 199
Query: 206 TVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGST 265
T+V+KPAEQTPL+ALY+G+LIKEAGFPPGV+NI+PG+GPT GAAI+SH I+KIAFTGST
Sbjct: 200 TMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGST 259
Query: 266 EVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSR 325
EVGKL++EAA RSNLKRVTLELGGK+P I+ ADADLD AVE AHQGVFFNQGQCCTA SR
Sbjct: 260 EVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASR 319
Query: 326 IFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKL 385
+FVEE +Y EFVRRSVE AK+R VG PFD TEQGPQID+KQ++KILELI+SG EGAKL
Sbjct: 320 VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKL 379
Query: 386 ECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGL 445
ECGG + KG FI+PTVFS VTD+MRIAKEEIFGPVQ IL+FK+++EVI+RAN++D+GL
Sbjct: 380 ECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGL 439
Query: 446 VAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSE 505
AAVFT +++KAL ++SA+++GTVWINCYNAL AQ+PFGGFKMSGNGRE+GE+ L EY+E
Sbjct: 440 TAAVFTKNLDKALKLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEYTE 499
Query: 506 VKTVTVKIPQKN 517
VKTVT+K+ KN
Sbjct: 500 VKTVTIKLGDKN 511
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 709 bits (1829), Expect = 0.0
Identities = 335/498 (67%), Positives = 410/498 (82%)
Query: 21 ASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKA 80
A+ +P+P E+ +IFINNEW ++ S + FP NP+TGE +C+V E DK D+DKA
Sbjct: 20 AATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKA 79
Query: 81 VQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDL 140
V+AAR AF LGS WRRMDAS RGRLL++LADL+ERDR LA +E+L+ GKP++ ++ VDL
Sbjct: 80 VKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDL 139
Query: 141 QGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPA 200
V+K RYYAGWADK HG TIP+DGD+F++TRHEP+GVCGQIIPWNFPLLM AWK+ PA
Sbjct: 140 DMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPA 199
Query: 201 LCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIA 260
L GN VV+K AEQTPL+ALY+ LIKEAGFPPGV+NI+PG+GPTAGAAIASH +DK+A
Sbjct: 200 LATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVA 259
Query: 261 FTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCC 320
FTGSTE+G++IQ AAG SNLKRVTLELGGKSPNII +DAD+D+AVEQAH +FFNQGQCC
Sbjct: 260 FTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCC 319
Query: 321 TAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVA 380
AGSR FV+E IY+EFV RSV RAK RVVG+PFD TEQGPQ+D+ Q+ KIL I +G
Sbjct: 320 CAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKILGYINTGKQ 379
Query: 381 EGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANN 440
EGAKL CGG +G+FI+PTVF +V D M IAKEEIFGPV +IL+FKT++EV+ RANN
Sbjct: 380 EGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTIEEVVGRANN 439
Query: 441 SDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGL 500
S +GL AAVFT D++KA +S A+QAGTVW+NCY+ AQSPFGG+KMSG+GRE+GE+GL
Sbjct: 440 STYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQSPFGGYKMSGSGRELGEYGL 499
Query: 501 REYSEVKTVTVKIPQKNS 518
+ Y+EVKTVTVK+PQKNS
Sbjct: 500 QAYTEVKTVTVKVPQKNS 517
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 706 bits (1823), Expect = 0.0
Identities = 333/501 (66%), Positives = 413/501 (82%)
Query: 18 ALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADI 77
A +S LPSP N +I Y ++FINNEWQ++ S + FP NP TGE + V E D+AD+
Sbjct: 17 ARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADV 76
Query: 78 DKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFY 137
D+AV+AAR AF LGS WRRMDASERGRLL++LADLVERDR LA++E+L+ GKPF +++
Sbjct: 77 DRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYA 136
Query: 138 VDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKI 197
+DL VIK +RY+AGWADK HG TIP+DG +F FTRHEP+GVCGQIIPWNFPL+M WK+
Sbjct: 137 LDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKL 196
Query: 198 APALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGID 257
APAL GNTVV+K AEQTPLSALY+ +LIKEAGFPPGV+NI+ GYGPTAGAAIA H+ +D
Sbjct: 197 APALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVD 256
Query: 258 KIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQG 317
K+AFTGSTEVG LIQ+AAG SNLKRVTLELGGKSP+I+ ADAD+++AVEQ H+ +FFN G
Sbjct: 257 KVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMG 316
Query: 318 QCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQS 377
QCC AGSR FVEESIY EF+ R+VE+AK+R VG+PF+ T+QGPQ+DK+Q+ ++L IQ
Sbjct: 317 QCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQL 376
Query: 378 GVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIER 437
G EGAKL CGG+ G +GFFI+PTVF V DDMRIAKEEIFGPVQ + +FK ++EV+ER
Sbjct: 377 GQKEGAKLLCGGERFGERGFFIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVER 436
Query: 438 ANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGE 497
ANN+ +GL AAVFT D++KA+ + A+QAGTVW+N YN + +PFGGFK SGNGRE+GE
Sbjct: 437 ANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGE 496
Query: 498 FGLREYSEVKTVTVKIPQKNS 518
GL+ Y+EVKTVT+K+PQKNS
Sbjct: 497 DGLKAYTEVKTVTIKVPQKNS 517
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 471 bits (1213), Expect = e-133
Identities = 244/478 (51%), Positives = 318/478 (66%), Gaps = 7/478 (1%)
Query: 39 KIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMD 98
++FI E+ ++E + NP G +C+V A D+DKAV AA+ AF G W ++
Sbjct: 423 QLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGR-WGKIS 481
Query: 99 ASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH 158
A +RGRL+ +LADL+E+ + LAT+E+L+ G + A + I+TFRY+AGW DKI
Sbjct: 482 ARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQ 541
Query: 159 GMTIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQ 214
G TIP++ T TR EP+GVCG IIPWN+PL+M +WK A L GNTVVIKPA+
Sbjct: 542 GSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQV 601
Query: 215 TPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEA 274
TPL+AL L +AG P GV+N+LPG G G ++ H + KI FTGSTEVGK I ++
Sbjct: 602 TPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKS 661
Query: 275 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 334
SN+K+V+LELGGKSP IIFAD DL+ AV+ VFFN+G+ C A R+FVE+SI++
Sbjct: 662 CAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHD 721
Query: 335 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 394
EFVRR VE ++ VG+P D T+ GPQ K++E Q GV EGA L CGG + R
Sbjct: 722 EFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPR 781
Query: 395 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFK--TMDEVIERANNSDFGLVAAVFTN 452
GFF EPTVF++V D M IAKEE FGPV I RF +D V+ RAN ++FGL + VFT
Sbjct: 782 PGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTR 841
Query: 453 DINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVT 510
DINKAL VS +QAGTV++N YN + +PFGGFK SG G+++GE L EY VKTVT
Sbjct: 842 DINKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLRVKTVT 899
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 470 bits (1210), Expect = e-132
Identities = 238/478 (49%), Positives = 326/478 (68%), Gaps = 7/478 (1%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
FIN ++ +++ G+ + NP G +C+V A AD+DKAV AA+ AF G W RM+A
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGE-WGRMNAR 504
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
ERGRL+ +LADL+E ++ LAT+E+L+ G + A + ++TFRY+AGW DKI G
Sbjct: 505 ERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGS 564
Query: 161 TIPVD----GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTP 216
TIP++ TFT+ EP+GVC IIPWN+PL+M AWK A L GNT+V+KPA+ TP
Sbjct: 565 TIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP 624
Query: 217 LSALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG 276
L+AL L +AGFP GVINI+PG G AG ++ H I K+ FTGST +GK I ++
Sbjct: 625 LTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCA 684
Query: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
SNLK+V+LELGGKSP IIF D +LD AV VFFN+G+ C A R+FVEESI++EF
Sbjct: 685 VSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEF 744
Query: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
V R VE K+ +G P D +T+ GPQ K K+L+ ++GV EGA L GG+ + R G
Sbjct: 745 VTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPG 804
Query: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKT--MDEVIERANNSDFGLVAAVFTNDI 454
FF+EPTVF++V D M +AKEE FGP+ I +F+ +D V++RAN++++GL + VFT DI
Sbjct: 805 FFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDI 864
Query: 455 NKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
NKA+ VS ++AGTV+IN YN + +PFGG K SG G+++GE L EY + KTVT++
Sbjct: 865 NKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLE 922
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 345 bits (886), Expect = 4e-95
Identities = 203/518 (39%), Positives = 292/518 (56%), Gaps = 25/518 (4%)
Query: 12 VKADPAALMASLHLL-PSPTPNLEIKYTKIFINNEWQNSESG-RVFPV--------YNPA 61
++A AAL L L PSP + T F+ ++ N G RV P + PA
Sbjct: 3 LRAGLAALSPLLRSLRPSPVAAMS---TGTFVVSQPLNYRGGARVEPADASGTEKAFEPA 59
Query: 62 TGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLA 121
TG + + + +++ AVQ A+ AF +W + ER R+L + A ++ +A
Sbjct: 60 TGRVIATFTCSGEKEVNLAVQNAKAAFK---IWSQKSGMERCRILLEAARIIREREDEIA 116
Query: 122 TMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCG 181
TME +N GK +A +D+ + YYAG A + G I + G F +TR EP+GVC
Sbjct: 117 TMECINNGKSIFEA-RLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
Query: 182 QIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPG 241
I WN+P + +WK APAL CGN +V KP+ TP+SAL + + EAG PPG+ N++ G
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
Query: 242 YGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADL 301
G G + H + K++FTGS G I E + + +K VTLELGGKSP IIF+D D+
Sbjct: 236 -GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKG-IKPVTLELGGKSPLIIFSDCDM 293
Query: 302 DYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGP 361
+ AV+ A F QGQ C G+R+FV++ I ++F V++ +R +G P T GP
Sbjct: 294 NNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGP 353
Query: 362 QIDKKQYNKILELIQSGVAEGAKLECGGKGLG------RKGFFIEPTVFSNVTDDMRIAK 415
I++ ++L ++ +GAK+ CGG + G+++ P V +N DDM K
Sbjct: 354 LINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVK 413
Query: 416 EEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYN 475
EEIFGPV IL F T EV+ERAN++ FGL A VFT DI +A V + +QAGT +IN YN
Sbjct: 414 EEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYN 473
Query: 476 ALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKI 513
+ PFGG+K SG GRE G + YS++KTV V++
Sbjct: 474 VSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEM 511
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 332 bits (850), Expect = 7e-91
Identities = 182/465 (39%), Positives = 272/465 (58%), Gaps = 16/465 (3%)
Query: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Query: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
Query: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPG 234
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ +AG PPG
Sbjct: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
Query: 235 VINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNI 294
V+NI+ G GP G A+ SH + I+FTGS + I + + + K+++LELGGK+P I
Sbjct: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAI 261
Query: 295 IFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFD 354
IF DA+LD + + F NQG+ C SRIFV++SIY EF++R VE ++ VG P D
Sbjct: 262 IFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSD 321
Query: 355 PTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNV 407
P G I K K+ ++ +AEGA++ CG + G+F+ PTV +++
Sbjct: 322 PLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDI 381
Query: 408 TDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAG 467
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 382 KDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSG 441
Query: 468 TVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 442 LVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 274 bits (700), Expect = 2e-73
Identities = 174/481 (36%), Positives = 254/481 (52%), Gaps = 20/481 (4%)
Query: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
Query: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
Query: 213 EQTPLSALYMGALIKEAGFPPGVINILPGYGPTA---GAAIASHIGIDKIAFTGSTEVGK 269
E TP SAL + L +AG P GV N++P A G AI + + KI+FTGST GK
Sbjct: 231 EDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGK 290
Query: 270 LIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVE 329
++ A S +KRV++ELGG +P I+F A++D AV A F N GQ C ++ V+
Sbjct: 291 ILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQ 349
Query: 330 ESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECG 388
I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + + V++GA + G
Sbjct: 350 RGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTG 409
Query: 389 GKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAA 448
GK F EPT+ NVT DM EE FGP+ +++F T +E I AN +D GL
Sbjct: 410 GKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGY 469
Query: 449 VFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 508
++ D + V+ ++ G V +N + + PFGG K SG GRE ++G+ EY E+K
Sbjct: 470 FYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKY 529
Query: 509 V 509
V
Sbjct: 530 V 530
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 265 bits (676), Expect = 1e-70
Identities = 163/465 (35%), Positives = 244/465 (52%), Gaps = 70/465 (15%)
Query: 58 YNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDR 117
Y+P+TGE C V + K +I+ AV+AAR AF W ER R+L+++ADL+E+
Sbjct: 28 YDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPS---WSSRSPQERSRVLNQVADLLEQSL 84
Query: 118 AVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFT---FTRH 174
A ES + GK A +D+ ++ FR++A + +H + D+ +T
Sbjct: 85 EEFAQAESKDQGKTLALARTMDIPRSVQNFRFFA--SSSLHHTSECTQMDHLGCMHYTVR 142
Query: 175 EPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPG 234
P+GV G I PWN PL + WKIAPA+ GNTV+ KP+E T ++A + L+ +AG PPG
Sbjct: 143 APVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPG 202
Query: 235 VINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNI 294
V+NI+ G GP G A+ SH + I+FTGS + I + + + K+++LELGGK+P I
Sbjct: 203 VVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSA-PHCKKLSLELGGKNPAI 261
Query: 295 IFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFD 354
IF DA+LD + + F NQ VR V+RA
Sbjct: 262 IFEDANLDECIPATVRSSFANQ--------------------VRSYVKRA---------- 291
Query: 355 PTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGG-------KGLGRKGFFIEPTVFSNV 407
+AEGA++ CG + G+F+ PTV +++
Sbjct: 292 ------------------------LAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDI 327
Query: 408 TDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAG 467
D+ EEIFGPV ++ F + +EVIERANN +GL A V+++++ + V+ +Q+G
Sbjct: 328 KDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSG 387
Query: 468 TVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
VW NC+ PFGG K SG GRE + ++E+KT+TVK
Sbjct: 388 LVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 432
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 265 bits (676), Expect = 1e-70
Identities = 174/494 (35%), Positives = 254/494 (51%), Gaps = 33/494 (6%)
Query: 38 TKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRM 97
T F+ W + + FPV +PA+G + V + + AV+AA AF WR +
Sbjct: 61 TDSFVGGRWLPAAA--TFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCR---WREV 115
Query: 98 DASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGW---- 153
A ER LL K +L+ +++ LA + + GKP +A G I ++ W
Sbjct: 116 SAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEA-----HGEILYSAFFLEWFSEE 170
Query: 154 ADKIHGMTIPVDG-DYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPA 212
A +++G I D +PIGV I PWNFP M K+ AL G TVV+KPA
Sbjct: 171 ARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPA 230
Query: 213 EQTPLSALYMGA-------------LIKEAGFPPGVINILPGYGPTA---GAAIASHIGI 256
E TP SAL + L +AG P GV N++P A G AI + +
Sbjct: 231 EDTPFSALALAEVNQGFLLDLDPLLLASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLV 290
Query: 257 DKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQ 316
KI+FTGST GK++ A S +KRV++ELGG +P I+F A++D AV A F N
Sbjct: 291 SKISFTGSTTTGKILLHHAANS-VKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 349
Query: 317 GQCCTAGSRIFVEESIYEEFVRRSVERAKRRV-VGSPFDPTTEQGPQIDKKQYNKILELI 375
GQ C ++ V+ I++ FV+ E K+ + VG+ F+ T QGP I++K K+ + +
Sbjct: 350 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQV 409
Query: 376 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 435
V++GA + GGK F EPT+ NVT DM EE FGP+ +++F T +E I
Sbjct: 410 NDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAI 469
Query: 436 ERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREM 495
AN +D GL ++ D + V+ ++ G V +N + + PFGG K SG GRE
Sbjct: 470 AIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREG 529
Query: 496 GEFGLREYSEVKTV 509
++G+ EY E+K V
Sbjct: 530 SKYGIDEYLELKYV 543
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 217 bits (553), Expect = 2e-56
Identities = 150/516 (29%), Positives = 254/516 (49%), Gaps = 28/516 (5%)
Query: 6 IEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQ 65
+++ +VK+ P AS PT K+FI ++ S+S + ++NPAT E
Sbjct: 15 LQVSSKVKSSPTWYSASSFSSSVPT-------VKLFIGGKFVESKSDKWIDIHNPATNEV 67
Query: 66 VCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMES 125
+ V +A KA++D A+ + + AF W R ++L + L++ + +A + +
Sbjct: 68 IGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLIT 124
Query: 126 LNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIP-VDGDYFTFTRHEPIGVCGQII 184
L GK A +G ++ + + G T+P + D ++ P+GVC I
Sbjct: 125 LEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIA 183
Query: 185 PWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGP 244
P+NFP ++ W A+ CGNT ++KP+E+ P + + + L++++G P G +NI+ G
Sbjct: 184 PFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHE 243
Query: 245 TAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYA 304
I H I I+F GS + G+ I E R KRV +G K+ ++ DA+ +
Sbjct: 244 AVN-FICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKENT 301
Query: 305 VEQAHQGVFFNQGQCCTA-GSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQI 363
+ Q F GQ C A + + V E+ ++++ VE AK V + P + GP I
Sbjct: 302 LNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLI 359
Query: 364 DKKQYNKILELIQSGVAEGAKLECGGKGLGRKGF----FIEPTVFSNVTDDMRIAKEEIF 419
+ ++ LI SG EGA + G+ + KG+ F+ PT+ SNV +M KEEIF
Sbjct: 360 TPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIF 419
Query: 420 GPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNA 479
GPV +L +T+DE I+ NN+ +G A+FT + A + + G V +N +
Sbjct: 420 GPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNV--PIPV 477
Query: 480 QSPFGGFKMS-----GNGREMGEFGLREYSEVKTVT 510
P F S G+ G+ G++ Y+++KT+T
Sbjct: 478 PLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTIT 513
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 215 bits (548), Expect = 7e-56
Identities = 148/480 (30%), Positives = 230/480 (47%), Gaps = 22/480 (4%)
Query: 43 NNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASER 102
N W G V Y PA E + V++A AD ++ V+ AR A+ +W + A +R
Sbjct: 56 NGSWGGR--GEVITTYCPANNEPIARVRQASVADYEETVKKAREAWK---IWADIPAPKR 110
Query: 103 GRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTI 162
G ++ ++ D + VL ++ SL GK ++ ++Q + Y G + I G +
Sbjct: 111 GEIVRQIGDALREKIQVLGSLVSLEMGKILVEGVG-EVQEYVDICDYAVGLSRMIGGPIL 169
Query: 163 PVD-GDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 221
P + + + P+G+ G I +NFP+ ++ W A A+ CGN + K A T L ++
Sbjct: 170 PSERSGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVA 229
Query: 222 MGALIK---EAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGK----LIQEA 274
+ +I E PG I L G G A+A ++ ++FTGST+VGK ++QE
Sbjct: 230 VTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQER 289
Query: 275 AGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE 334
GRS LELGG + I F DADL V A GQ CT R+F+ ESI++
Sbjct: 290 FGRS-----LLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHD 344
Query: 335 EFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGR 394
E V R + + VG+P+DP GP K+ + L ++ EG + GGK + R
Sbjct: 345 EVVNRLKKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDR 404
Query: 395 KGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDI 454
G ++EPT+ + + D IA E F P+ + +FK +EV N GL +++FT D+
Sbjct: 405 PGNYVEPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDL 464
Query: 455 NKAL--TVSSAMQAGTVWINC-YNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTV 511
+ G V +N + FGG K +G GRE G ++Y T T+
Sbjct: 465 GRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 181 bits (458), Expect = 2e-45
Identities = 137/465 (29%), Positives = 219/465 (47%), Gaps = 25/465 (5%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPL- 208
Query: 219 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS 278
+ L E G PG++N+L G +AS GI K+AF G+ E G+ ++ +
Sbjct: 209 --LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
Query: 279 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR 338
+ L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +R
Sbjct: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
Query: 339 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF 398
R ER R G D + G + + + ++ ++GA++ G + F+
Sbjct: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY 380
Query: 399 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL 458
PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL
Sbjct: 381 -PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 439
Query: 459 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 503
+ +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 440 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
Score = 79.7 bits (195), Expect = 6e-15
Identities = 82/278 (29%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 509 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 562
Query: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 563 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 619
Query: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 620 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
Query: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 250
L F +APAL GNTVV+ P+ PL AL + + FP G+ N++ G +
Sbjct: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 733
Query: 251 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELG 288
A H + + + GS + G E A NLK V G
Sbjct: 734 ALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 770
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 148 bits (374), Expect = 1e-35
Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238
I P+NF + APAL GN V+ KP++ L++ + +++EAG PP +I
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293
+P GP G + S + I FTGS K + + ++ R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496
AG +IN ++ Q PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 148 bits (374), Expect = 1e-35
Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 84
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 85 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 142
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238
I P+NF + APAL GN V+ KP++ L++ + +++EAG PP +I
Sbjct: 143 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 201
Query: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293
+P GP G + S + I FTGS K + + ++ R+ E GGK+ +
Sbjct: 202 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 261
Query: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 262 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 321
Query: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 322 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 381
Query: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 382 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 439
Query: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496
AG +IN ++ Q PFGG + SG + G
Sbjct: 440 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 148 bits (374), Expect = 1e-35
Identities = 125/454 (27%), Positives = 217/454 (47%), Gaps = 28/454 (6%)
Query: 63 GEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLAT 122
G +V + ADK+ ++KA++AA A W ++R ++ K AD++ R
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAA---RKEWDLKPIADRAQIFLKAADMLSGPRRAEIL 144
Query: 123 MESLNG-GKPFLQAFYVDLQGVIKTFRYYAGWADKIHG---MTIPVDGDYFTFTRHEPIG 178
+++ G GK +QA +I FR+ A +A ++ G +++P + + E G
Sbjct: 145 AKTMVGQGKTVIQAEIDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNSTVYRGLE--G 202
Query: 179 VCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINI 238
I P+NF + APAL GN V+ KP++ L++ + +++EAG PP +I
Sbjct: 203 FVAAISPFNFTAIGGNLAGAPALM-GNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQF 261
Query: 239 LPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS-----NLKRVTLELGGKSPN 293
+P GP G + S + I FTGS K + + ++ R+ E GGK+ +
Sbjct: 262 VPADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFH 321
Query: 294 IIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPF 353
+ AD++ V + F GQ C+A SR++V S++ + R +E R VG P
Sbjct: 322 FVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDPA 381
Query: 354 -DPTTEQGPQIDKKQYNKILELIQ-SGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDM 411
D T ID K + +I + ++ + + + GGK G+F+EP + +
Sbjct: 382 EDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQE 441
Query: 412 RIAKEEIFGPVQEIL-----RFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQ- 465
I KEEIFGPV + ++K ++++ + + +GL AVF+ D + + ++
Sbjct: 442 PIMKEEIFGPVLSVYVYPDDKYKETLQLVD--STTSYGLTGAVFSQDKDVVQEATKVLRN 499
Query: 466 -AGTVWIN--CYNALNAQSPFGGFKMSGNGREMG 496
AG +IN ++ Q PFGG + SG + G
Sbjct: 500 AAGNFYINDKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 145 bits (366), Expect = 9e-35
Identities = 122/443 (27%), Positives = 205/443 (46%), Gaps = 22/443 (4%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 252
+ A+ GN+VV+KP+E + A + +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 253 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 312
D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + G
Sbjct: 180 RF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 313 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 372
F N GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 373 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 432
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++
Sbjct: 296 -----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 433 EVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS 489
E I+ N + L +F+++ I K + +S+ + + L++ PFGG S
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408
Query: 490 GNGREMGEFGLREYSEVKTVTVK 512
G G G+ +S ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 145 bits (366), Expect = 9e-35
Identities = 122/443 (27%), Positives = 205/443 (46%), Gaps = 22/443 (4%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 252
+ A+ GN+VV+KP+E + A + +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 253 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 312
D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + G
Sbjct: 180 RF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 313 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 372
F N GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 373 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 432
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++
Sbjct: 296 -----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 433 EVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS 489
E I+ N + L +F+++ I K + +S+ + + L++ PFGG S
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408
Query: 490 GNGREMGEFGLREYSEVKTVTVK 512
G G G+ +S ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 145 bits (366), Expect = 9e-35
Identities = 122/443 (27%), Positives = 205/443 (46%), Gaps = 22/443 (4%)
Query: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 252
+ A+ GN+VV+KP+E + A + +I + + ++ G P +
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
Query: 253 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 312
D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + G
Sbjct: 180 RF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 313 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 372
F N GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
Query: 373 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 432
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++
Sbjct: 296 -----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
Query: 433 EVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS 489
E I+ N + L +F+++ I K + +S+ + + L++ PFGG S
Sbjct: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408
Query: 490 GNGREMGEFGLREYSEVKTVTVK 512
G G G+ +S ++ V+
Sbjct: 409 GMGSYHGKKSFETFSHRRSCLVR 431
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 140 bits (353), Expect = 3e-33
Identities = 131/467 (28%), Positives = 197/467 (42%), Gaps = 80/467 (17%)
Query: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAF---KGWSAHPGV 99
Query: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
Query: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
I EP+GV G I+P F L W+I PAL G TVV + PA P
Sbjct: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP-- 207
Query: 219 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVG--KLIQEAAG 276
L + L E G PG++N+L G +AS GI K+AF G+ E G LIQE+
Sbjct: 208 -LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEGGLRLLIQESVW 265
Query: 277 RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEF 336
++R+ +G + + LD AV+ +G C +
Sbjct: 266 DEAMRRLQERMGR-----LRSGRGLDGAVDMGARGA----AAC---------------DL 301
Query: 337 VRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKG 396
V+R V A+ QG Q+ Q+G +
Sbjct: 302 VQRFVREAQ------------SQGAQV-----------FQAGDVPSERP----------- 327
Query: 397 FFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINK 456
F PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +
Sbjct: 328 -FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQ 386
Query: 457 ALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 503
AL + +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 387 ALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 433
Score = 79.7 bits (195), Expect = 6e-15
Identities = 82/278 (29%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 458 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 511
Query: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 512 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 568
Query: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 569 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 623
Query: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 250
L F +APAL GNTVV+ P+ PL AL + + FP G+ N++ G +
Sbjct: 624 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 682
Query: 251 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELG 288
A H + + + GS + G E A NLK V G
Sbjct: 683 ALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 719
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 133 bits (334), Expect = 4e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 471 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 133 bits (334), Expect = 4e-31
Identities = 105/345 (30%), Positives = 162/345 (46%), Gaps = 15/345 (4%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
+ + +P+GV I WN+P ++ + A+ GN V+IKP+E + +A + L+ +
Sbjct: 96 YIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYL 155
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
I I G T D I +TG+T VGK++ EAA + +L VTLELGGK
Sbjct: 156 DQDLYIVINGGVEETTELLKQR---FDHIFYTGNTAVGKIVMEAAAK-HLTPVTLELGGK 211
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
SP I D DLD + G + N GQ C A I E S+ + V + E K G
Sbjct: 212 SPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVK-EFYG 270
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ + I+ + + +IL L+ EG K+ GG+ +I PTV ++V
Sbjct: 271 ENIKESPDYERIINLRHFKRILSLL-----EGQKIAFGGE-TDEATRYIAPTVLTDVDPK 324
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
++ +EEIFGP+ I+ K +DE I N + L VF+++ + +G V
Sbjct: 325 TKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVT 384
Query: 471 IN---CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 512
N + LN+ PFGG SG G G+ +S + +K
Sbjct: 385 GNDVIMHFTLNS-FPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLK 428
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 2e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 127 bits (320), Expect = 2e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 62 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 120
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 121 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 177
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 178 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 236
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 237 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 290
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 291 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 350
Query: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 351 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 396
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 127 bits (320), Expect = 2e-29
Identities = 99/346 (28%), Positives = 158/346 (45%), Gaps = 13/346 (3%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
F R EP G+ I PWN+PL + + AL GN VV+KP+E + + ++ +
Sbjct: 99 FIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQY- 157
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
++ G GP + H D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 158 VDQSCFAVVLG-GPQETGQLLEH-RFDYIFFTGSPRVGKIVMTAAAK-HLTPVTLELGGK 214
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 215 NPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSPEMQERLL-PALQSTITRFYG 273
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 274 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-DESDRYIAPTVLVDVQEM 327
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVW 470
+ +EEIFGP+ I+ +++DE IE N + L F+N V + +G
Sbjct: 328 EPVMQEEIFGPILPIVNVQSLDEAIEFINRREKPLALYAFSNSSQVVKRVLTQTSSGGFC 387
Query: 471 IN--CYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIP 514
N + A PFGG SG GR G+F +S + ++ P
Sbjct: 388 GNDGFMHMTLASLPFGGVGASGMGRYHGKFSFDTFSHHRACLLRSP 433
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 122 bits (307), Expect = 6e-28
Identities = 98/342 (28%), Positives = 160/342 (46%), Gaps = 17/342 (4%)
Query: 171 FTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAG 230
F EP G+ I PWN+PL + + AL G+ VV+KP+E + + + ++ +
Sbjct: 18 FIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEISQGTEKVLAEVLPQY- 76
Query: 231 FPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGK 290
++ G GP + H +D I FTGS VGK++ AA + +L VTLELGGK
Sbjct: 77 LDQSCFAVVLG-GPQETGQLLEH-KLDYIFFTGSPRVGKIVMTAATK-HLTPVTLELGGK 133
Query: 291 SPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVG 350
+P + + D + +FN GQ C A + + E + +++ R G
Sbjct: 134 NPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLP-ALQSTITRFYG 192
Query: 351 SPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDD 410
+ G I++KQ+ ++ L+ G ++ GG+ +I PTV +V +
Sbjct: 193 DDPQSSPNLGRIINQKQFQRLRALLGCG-----RVAIGGQS-NESDRYIAPTVLVDVQET 246
Query: 411 MRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL-TVSSAMQA 466
+ +EEIFGP+ I+ +++DE I+ N + L F+N +N+ L SS
Sbjct: 247 EPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSSGSFG 306
Query: 467 GTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT 508
G + L+ PFGG SG GR G+F +S +T
Sbjct: 307 GNEGFTYISLLSV--PFGGVGHSGMGRYHGKFTFDTFSHHRT 346
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,476,444
Number of Sequences: 37866
Number of extensions: 881209
Number of successful extensions: 1839
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1697
Number of HSP's gapped (non-prelim): 44
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.