Search of human proteins with 121114304

Search of human proteins with 121114304

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
         (993 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]            2036   0.0  
gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncoge...   455   e-127
gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene...   454   e-127
gi|27262659 colony stimulating factor 1 receptor precursor [Homo...   444   e-124
gi|5453870 platelet-derived growth factor receptor alpha precurs...   423   e-118
gi|4505683 platelet-derived growth factor receptor beta precurso...   400   e-111
gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [...   338   2e-92
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]    330   3e-90
gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [...   326   6e-89
gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [...   326   6e-89
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu...   286   9e-77
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu...   285   1e-76
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu...   285   1e-76
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu...   285   1e-76
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu...   283   7e-76
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu...   282   1e-75
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu...   281   3e-75
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu...   279   8e-75
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu...   279   8e-75
gi|10862701 ret proto-oncogene isoform c [Homo sapiens]               255   2e-67
gi|10862703 ret proto-oncogene isoform a [Homo sapiens]               255   2e-67
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu...   193   6e-49
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur...   193   6e-49
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs...   193   6e-49
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur...   190   7e-48
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur...   190   7e-48
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur...   190   7e-48
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu...   190   7e-48
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like...   186   7e-47
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   182   1e-45

>gi|121114304 fms-related tyrosine kinase 3 [Homo sapiens]
          Length = 993

 Score = 2036 bits (5275), Expect = 0.0
 Identities = 993/993 (100%), Positives = 993/993 (100%)

Query: 1   MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP 60
           MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP
Sbjct: 1   MPALARDGGQLPLLVVFSAMIFGTITNQDLPVIKCVLINHKNNDSSVGKSSSYPMVSESP 60

Query: 61  EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL 120
           EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL
Sbjct: 61  EDLGCALRPQSSGTVYEAAAVEVDVSASITLQVLVDAPGNISCLWVFKHSSLNCQPHFDL 120

Query: 121 QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD 180
           QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD
Sbjct: 121 QNRGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQD 180

Query: 181 ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE 240
           ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE
Sbjct: 181 ALVCISESVPEPIVEWVLCDSQGESCKEESPAVVKKEEKVLHELFGTDIRCCARNELGRE 240

Query: 241 CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM 300
           CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM
Sbjct: 241 CTRLFTIDLNQTPQTTLPQLFLKVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEM 300

Query: 301 STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE 360
           STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE
Sbjct: 301 STYSTNRTMIRILFAFVSSVARNDTGYYTCSSSKHPSQSALVTIVEKGFINATNSSEDYE 360

Query: 361 IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA 420
           IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA
Sbjct: 361 IDQYEEFCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIFHA 420

Query: 421 ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE 480
           ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE
Sbjct: 421 ENDDAQFTKMFTLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE 480

Query: 481 GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD 540
           GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD
Sbjct: 481 GVWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQD 540

Query: 541 NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD 600
           NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD
Sbjct: 541 NISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYD 600

Query: 601 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 660
           LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS
Sbjct: 601 LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 660

Query: 661 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE 720
           ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE
Sbjct: 661 ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE 720

Query: 721 HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL 780
           HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL
Sbjct: 721 HNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDL 780

Query: 781 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 840
           NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS
Sbjct: 781 NVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDS 840

Query: 841 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK 900
           NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK
Sbjct: 841 NYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYK 900

Query: 901 LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG 960
           LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG
Sbjct: 901 LIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDG 960

Query: 961 RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 993
           RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS
Sbjct: 961 RVSECPHTYQNRRPFSREMDLGLLSPQAQVEDS 993


>gi|148005039 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 2 precursor [Homo sapiens]
          Length = 972

 Score =  455 bits (1170), Expect = e-127
 Identities = 276/726 (38%), Positives = 398/726 (54%), Gaps = 42/726 (5%)

Query: 262 LKVGEPLWIRCKAVHVNHGFGLTWELEN---KALEEGNYFEMSTYSTNRTMIRILFAFVS 318
           L+ GE   + C    V+     TW+ EN   K  E+ N +    ++  R         +S
Sbjct: 223 LREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLT----IS 278

Query: 319 SVARNDTGYYTCSSSKHPSQSALVT---IVEKGFINATNS-SEDYEIDQYEEFCFSVRFK 374
           S   ND+G + C ++     + + T   +V+KGFIN     +    ++  E     V ++
Sbjct: 279 SARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYE 338

Query: 375 AYPQIRCT-WTFSRKSFPCEQKGLDNGYSIS--KFCNHKH-------QPGEYIFHAENDD 424
           A+P+     W +  ++F  + +      + S  ++ +  H       + G Y F   N D
Sbjct: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSD 398

Query: 425 AQFTKMFTLNIRRKPQVLA--EASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE-G 481
                 F + +  KP++L           C + G+P P+  W  C      C+  +    
Sbjct: 399 VNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVD 458

Query: 482 VWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLG-TSCETILLNSPGPFP---F 537
           V    ++   FG+ V  S+++ S       V+C AYN +G TS            P   F
Sbjct: 459 VQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKEQIHPHTLF 518

Query: 538 IQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREY 597
               I F    G+  + +++LT    +KY ++  YE Q ++V+      N Y Y+D  + 
Sbjct: 519 TPLLIGFVIVAGMMCIIVMILT----YKYLQKPMYEVQWKVVEEING--NNYVYIDPTQL 572

Query: 598 EYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREA 657
            YD KWEFPR  L FGK LG+GAFGKV+ ATAYG+ K+  ++ VAVKMLK  A  +EREA
Sbjct: 573 PYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREA 632

Query: 658 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEI 717
           LMSELK+++ LG+H NIVNLLGACT+ GP  +I EYCCYGDLLN+LR KR+ F  +  E 
Sbjct: 633 LMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICSKQED 692

Query: 718 FKEHNFSFYPTFQSHPNSSMPGSRE--VQIHPDSDQISGLHGNSFHSE---DEIEYENQK 772
             E   + Y        SS   S    + + P    +     +   S      IE +   
Sbjct: 693 HAEA--ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIERDVTP 750

Query: 773 RLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGL 832
            + E+++L  L  EDLL F+YQVAKGM FL  K+C+HRDLAARN+L+THG++ KICDFGL
Sbjct: 751 AIMEDDEL-ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGL 809

Query: 833 ARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGI 892
           ARDI +DSNYVV+GNARLPVKWMAPES+F  +YT +SDVWSYGI LWE+FSLG +PYPG+
Sbjct: 810 ARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGM 869

Query: 893 PVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEE 952
           PVD+ FYK+I+ GF+M  P +A  E+Y IM++CW  D  KRP+F  +   +  Q++++  
Sbjct: 870 PVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISESTN 929

Query: 953 AMYQNV 958
            +Y N+
Sbjct: 930 HIYSNL 935



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 123 RGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDAL 182
           R V  + + ++  T+ G Y   + +   N  I F V + NT    L   Y R +     L
Sbjct: 372 RYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYV-NTKPEILT--YDRLVNGM--L 426

Query: 183 VCISESVPEPIVEWVLCDSQGESC 206
            C++   PEP ++W  C    + C
Sbjct: 427 QCVAAGFPEPTIDWYFCPGTEQRC 450


>gi|4557695 v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
           homolog isoform 1 precursor [Homo sapiens]
          Length = 976

 Score =  454 bits (1167), Expect = e-127
 Identities = 274/730 (37%), Positives = 397/730 (54%), Gaps = 46/730 (6%)

Query: 262 LKVGEPLWIRCKAVHVNHGFGLTWELEN---KALEEGNYFEMSTYSTNRTMIRILFAFVS 318
           L+ GE   + C    V+     TW+ EN   K  E+ N +    ++  R         +S
Sbjct: 223 LREGEEFTVTCTIKDVSSSVYSTWKRENSQTKLQEKYNSWHHGDFNYERQATLT----IS 278

Query: 319 SVARNDTGYYTCSSSKHPSQSALVT---IVEKGFINATNS-SEDYEIDQYEEFCFSVRFK 374
           S   ND+G + C ++     + + T   +V+KGFIN     +    ++  E     V ++
Sbjct: 279 SARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIFPMINTTVFVNDGENVDLIVEYE 338

Query: 375 AYPQIRCT-WTFSRKSFPCEQKGLDNGYSIS--KFCNHKH-------QPGEYIFHAENDD 424
           A+P+     W +  ++F  + +      + S  ++ +  H       + G Y F   N D
Sbjct: 339 AFPKPEHQQWIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGGTYTFLVSNSD 398

Query: 425 AQFTKMFTLNIRRKPQVLA--EASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITE-G 481
                 F + +  KP++L           C + G+P P+  W  C      C+  +    
Sbjct: 399 VNAAIAFNVYVNTKPEILTYDRLVNGMLQCVAAGFPEPTIDWYFCPGTEQRCSASVLPVD 458

Query: 482 VWNRKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFP----- 536
           V    ++   FG+ V  S+++ S       V+C AYN +G +         G        
Sbjct: 459 VQTLNSSGPPFGKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNFAFKGNNKEQIHP 518

Query: 537 ---FIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVD 593
              F    I F    G+  + +++LT    +KY ++  YE Q ++V+      N Y Y+D
Sbjct: 519 HTLFTPLLIGFVIVAGMMCIIVMILT----YKYLQKPMYEVQWKVVEEING--NNYVYID 572

Query: 594 FREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSS 653
             +  YD KWEFPR  L FGK LG+GAFGKV+ ATAYG+ K+  ++ VAVKMLK  A  +
Sbjct: 573 PTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLT 632

Query: 654 EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRT 713
           EREALMSELK+++ LG+H NIVNLLGACT+ GP  +I EYCCYGDLLN+LR KR+ F  +
Sbjct: 633 EREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCYGDLLNFLRRKRDSFICS 692

Query: 714 WTEIFKEHNFSFYPTFQSHPNSSMPGSRE--VQIHPDSDQISGLHGNSFHSE---DEIEY 768
             E   E   + Y        SS   S    + + P    +     +   S      IE 
Sbjct: 693 KQEDHAEA--ALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRRSVRIGSYIER 750

Query: 769 ENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKIC 828
           +    + E+++L  L  EDLL F+YQVAKGM FL  K+C+HRDLAARN+L+THG++ KIC
Sbjct: 751 DVTPAIMEDDEL-ALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKIC 809

Query: 829 DFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNP 888
           DFGLARDI +DSNYVV+GNARLPVKWMAPES+F  +YT +SDVWSYGI LWE+FSLG +P
Sbjct: 810 DFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSP 869

Query: 889 YPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLA 948
           YPG+PVD+ FYK+I+ GF+M  P +A  E+Y IM++CW  D  KRP+F  +   +  Q++
Sbjct: 870 YPGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQIS 929

Query: 949 DAEEAMYQNV 958
           ++   +Y N+
Sbjct: 930 ESTNHIYSNL 939



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 5/84 (5%)

Query: 123 RGVVSMVILKMTETQAGEYLLFIQSEATNYTILFTVSIRNTLLYTLRRPYFRKMENQDAL 182
           R V  + + ++  T+ G Y   + +   N  I F V + NT    L   Y R +     L
Sbjct: 372 RYVSELHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYV-NTKPEILT--YDRLVNGM--L 426

Query: 183 VCISESVPEPIVEWVLCDSQGESC 206
            C++   PEP ++W  C    + C
Sbjct: 427 QCVAAGFPEPTIDWYFCPGTEQRC 450


>gi|27262659 colony stimulating factor 1 receptor precursor [Homo
           sapiens]
          Length = 972

 Score =  444 bits (1142), Expect = e-124
 Identities = 279/753 (37%), Positives = 404/753 (53%), Gaps = 81/753 (10%)

Query: 255 TTLPQLFLKV-GEPLWIRCKAVHVNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRIL 313
           T +P   +++ GE   I C A  V+  F +  +  N  L      + S +  NR   ++L
Sbjct: 206 TLVPAELVRIRGEAAQIVCSASSVDVNFDVFLQHNNTKLAIP---QQSDFHNNRYQ-KVL 261

Query: 314 FAFVSSVARNDTGYYTCSSS----KHPSQSALVTIVEKGFINATNSSE-DYEIDQYEEFC 368
              +  V     G Y+C +S    KH S S    +VE  ++N ++      E+   E   
Sbjct: 262 TLNLDQVDFQHAGNYSCVASNVQGKH-STSMFFRVVESAYLNLSSEQNLIQEVTVGEGLN 320

Query: 369 FSVRFKAYPQIR-CTWTF----------SRKSFPCEQKGLDNGYSISKFCNHKHQPGEYI 417
             V  +AYP ++   WT+           + +    +    + +++S       + G Y 
Sbjct: 321 LKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSEAGRYS 380

Query: 418 FHAENDDAQFTKMFTLNIRRKPQVLAEASASQAS----CFSDGYPLPSWTWKKCSDKSPN 473
           F A N        F L +R  P+V    +    S    C + GYP P+ TW +CS  +  
Sbjct: 381 FLARNPGGWRALTFELTLRYPPEVSVIWTFINGSGTLLCAASGYPQPNVTWLQCSGHTDR 440

Query: 474 CTEEITEGVWN----RKANRKVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILL 529
           C E     VW+       +++ F +    S L +         +C A+NS+G+     + 
Sbjct: 441 CDEAQVLQVWDDPYPEVLSQEPFHKVTVQSLLTVETLEHNQTYECRAHNSVGSGSWAFIP 500

Query: 530 NSPGPFPFIQDNISFYATIGVCL---LFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSD 586
            S G      D   F   +  C+     +++L LL+ +KYK++ +Y+ + ++++      
Sbjct: 501 ISAGAHTHPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRWKIIE--SYEG 558

Query: 587 NEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKML 646
           N Y ++D  +  Y+ KWEFPR NL+FGK LG+GAFGKV+ ATA+G+ K    ++VAVKML
Sbjct: 559 NSYTFIDPTQLPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKML 618

Query: 647 KEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSK 706
           K  A + E+EALMSELK+M+ LG HENIVNLLGACT  GP+ +I EYCCYGDLLN+LR K
Sbjct: 619 KSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRK 678

Query: 707 RE--------------------KFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIH 746
            E                      H     + ++  FS               S+ V  +
Sbjct: 679 AEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFS---------------SQGVDTY 723

Query: 747 PDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKS 806
            +   +S    +SF  +D           ++ED   L   DLL F+ QVA+GM FL  K+
Sbjct: 724 VEMRPVSTSSNDSFSEQDL----------DKEDGRPLELRDLLHFSSQVAQGMAFLASKN 773

Query: 807 CVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYT 866
           C+HRD+AARNVL+T+G V KI DFGLARDIM+DSNY+V+GNARLPVKWMAPES+F+ +YT
Sbjct: 774 CIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPESIFDCVYT 833

Query: 867 IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCW 926
           ++SDVWSYGILLWEIFSLG+NPYPGI V++ FYKL+++G++M QP +A + IY IMQ+CW
Sbjct: 834 VQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQACW 893

Query: 927 AFDSRKRPSFPNLTSFLGCQL-ADAEEAMYQNV 958
           A +   RP+F  + SFL  Q   D  E  Y N+
Sbjct: 894 ALEPTHRPTFQQICSFLQEQAQEDRRERDYTNL 926



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 30/139 (21%), Positives = 59/139 (42%), Gaps = 19/139 (13%)

Query: 82  EVDVSASITLQVLVDA-PGNISCLWVFKHSSLNCQPHFDLQN-------RGVVSMVILKM 133
           EV V   + L+V+V+A PG     W +     + QP   L N       R   ++ + ++
Sbjct: 312 EVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRL 371

Query: 134 TETQAGEYLLFIQSEATNYTILFTVSIRN----TLLYTLRRPYFRKMENQDALVCISESV 189
             ++AG Y    ++      + F +++R     ++++T        +     L+C +   
Sbjct: 372 KPSEAGRYSFLARNPGGWRALTFELTLRYPPEVSVIWTF-------INGSGTLLCAASGY 424

Query: 190 PEPIVEWVLCDSQGESCKE 208
           P+P V W+ C    + C E
Sbjct: 425 PQPNVTWLQCSGHTDRCDE 443


>gi|5453870 platelet-derived growth factor receptor alpha precursor
           [Homo sapiens]
          Length = 1089

 Score =  423 bits (1088), Expect = e-118
 Identities = 273/755 (36%), Positives = 398/755 (52%), Gaps = 74/755 (9%)

Query: 263 KVGEPLWIRCKAVHVNHGFGLTWELENKALEEGNYF--EMSTYSTNRTMIRILFAF-VSS 319
           K GE + + C AV  N    L W    +   +G     E+   S     I++++   V  
Sbjct: 226 KSGETIVVTC-AVFNNEVVDLQWTYPGEVKGKGITMLEEIKVPS-----IKLVYTLTVPE 279

Query: 320 VARNDTGYYTCSSSKHPSQ-----SALVTIVEKGFINATNSSEDYE-IDQYEEFCFSVRF 373
               D+G Y C++ +   +        +++ EKGFI    +    E ++ +E   F V  
Sbjct: 280 ATVKDSGDYECAARQATREVKEMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEV 339

Query: 374 KAYPQIRCTW---------TFSRKSFPCEQKGLDNGYSISKFCNHKHQP-GEYIFHAEND 423
           +AYP  R +W           +  +   E+       S  K    K +  G Y   A+N+
Sbjct: 340 RAYPPPRISWLKNNLTLIENLTEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNE 399

Query: 424 DAQFTKMFTLNIRRKPQVL-------AEASASQASCFSDGYPLPSWTWKKCSDKSPNCTE 476
           DA  +  F L  +    +L                C ++G PLP   W  C D    C  
Sbjct: 400 DAVKSYTFELLTQVPSSILDLVDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIK-KCNN 458

Query: 477 EITEGVWNRKANR------KVFGQWVSS--STLNMSEAIKGFLVKCCAYNSLGTSCETIL 528
           E +   W   AN       ++  +  S+    +  ++  +   V+C A N LG     + 
Sbjct: 459 ETS---WTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELK 515

Query: 529 LNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNE 588
           L +P     ++  ++  A + V L+ +++  +++   +K++ RYE + ++++      +E
Sbjct: 516 LVAPT----LRSELTVAAAVLVLLVIVIISLIVLVVIWKQKPRYEIRWRVIESISPDGHE 571

Query: 589 YFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKE 648
           Y YVD  +  YD +WEFPR+ L  G+VLGSGAFGKV+  TAYG+S++   ++VAVKMLK 
Sbjct: 572 YIYVDPMQLPYDSRWEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRSQPVMKVAVKMLKP 631

Query: 649 KADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKRE 708
            A SSE++ALMSELK+MT LG H NIVNLLGACT SGPIY+I EYC YGDL+NYL   R+
Sbjct: 632 TARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRD 691

Query: 709 KF-----------------------HRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQI 745
            F                        R++  +  E+N  +    Q+     +P     ++
Sbjct: 692 SFLSHHPEKPKKELDIFGLNPADESTRSYVILSFENNGDYMDMKQADTTQYVPMLERKEV 751

Query: 746 HPDSDQISGLHGN--SFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLE 803
              SD    L+    S+  +  ++ E  K L  +++   LT  DLL F YQVA+GMEFL 
Sbjct: 752 SKYSDIQRSLYDRPASYKKKSMLDSE-VKNLLSDDNSEGLTLLDLLSFTYQVARGMEFLA 810

Query: 804 FKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEG 863
            K+CVHRDLAARNVL+  GK+VKICDFGLARDIM DSNYV +G+  LPVKWMAPES+F+ 
Sbjct: 811 SKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDN 870

Query: 864 IYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQ 923
           +YT  SDVWSYGILLWEIFSLG  PYPG+ VD+ FY  I++G++M +P +AT E+Y IM 
Sbjct: 871 LYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMV 930

Query: 924 SCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNV 958
            CW  +  KRPSF +L+  +   L    +  Y+ +
Sbjct: 931 KCWNSEPEKRPSFYHLSEIVENLLPGQYKKSYEKI 965



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 26/132 (19%), Positives = 52/132 (39%), Gaps = 23/132 (17%)

Query: 130 ILKMTETQAGEYLLFIQSE--ATNYTILFTVSIRNTLLYTLRRPYFRKMENQDALVCISE 187
           +++  E  +G Y +  Q+E    +YT      + +++L  +   +         + C +E
Sbjct: 381 LIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDLVDDHH--GSTGGQTVRCTAE 438

Query: 188 SVPEPIVEWVLCDSQGESCKEESPAVVKKE-EKVLHELFGTD------------------ 228
             P P +EW++C    +   E S  ++      ++ E+   D                  
Sbjct: 439 GTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRDRSTVEGRVTFAKVEETIA 498

Query: 229 IRCCARNELGRE 240
           +RC A+N LG E
Sbjct: 499 VRCLAKNLLGAE 510


>gi|4505683 platelet-derived growth factor receptor beta precursor
           [Homo sapiens]
          Length = 1106

 Score =  400 bits (1027), Expect = e-111
 Identities = 253/710 (35%), Positives = 365/710 (51%), Gaps = 64/710 (9%)

Query: 317 VSSVARNDTGYYTC----SSSKHPSQSAL-VTIVEKGFINATNSSEDYEIDQ-YEEFCFS 370
           + S    D+G YTC    S + H  + A+ +T+VE G++         +  + +      
Sbjct: 278 IPSAELEDSGTYTCNVTESVNDHQDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQ 337

Query: 371 VRFKAYPQIRCTWTFSRKSFPCEQKG----LDNGYSISKFCNHKH-------QPGEYIFH 419
           V F+AYP     W    ++      G         S +++ +          + G Y   
Sbjct: 338 VVFEAYPPPTVLWFKDNRTLGDSSAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMR 397

Query: 420 AENDDAQFTKMFTLNIRRKPQVLA------EASASQASCFSDGYPLPSWTWKKCSDKSPN 473
           A ++DA+    F L I    +VL       ++      C   G P P+  W  C D    
Sbjct: 398 AFHEDAEVQLSFQLQINVPVRVLELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLK-R 456

Query: 474 CTEEITEGVWNRKANRKV-----FGQWVSS------STLNMSEAIKGFLVKCCAYNSLGT 522
           C  E+   +    +  +         W         STL +    +   V+C   N++G 
Sbjct: 457 CPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQ 516

Query: 523 SCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVT 582
             + +++  P   PF    IS  A + + +L I+ L +LI   ++K+ RYE + ++++  
Sbjct: 517 DTQEVIV-VPHSLPFKVVVIS--AILALVVLTIISLIILIM-LWQKKPRYEIRWKVIESV 572

Query: 583 GSSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVA 642
            S  +EY YVD  +  YD  WE PR+ L  G+ LGSGAFG+V+ ATA+G+S +  +++VA
Sbjct: 573 SSDGHEYIYVDPMQLPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQATMKVA 632

Query: 643 VKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNY 702
           VKMLK  A SSE++ALMSELK+M+ LG H N+VNLLGACT  GPIY+I EYC YGDL++Y
Sbjct: 633 VKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDY 692

Query: 703 LRSKREKFHRTWTEIFKEHNFSFY----------PTFQSHPNSSMPGSREVQIHPDSDQI 752
           L   +  F +  ++  +  +   Y          P+  S    S  G  ++      D +
Sbjct: 693 LHRNKHTFLQHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYV 752

Query: 753 SGLHGNSFHSEDEIE-------YENQKRLEEE--------EDLNVLTFEDLLCFAYQVAK 797
             L         +IE       Y+N      E         +  VL++ DL+ F+YQVA 
Sbjct: 753 PMLDMKGDVKYADIESSNYMAPYDNYVPSAPERTCRATLINESPVLSYMDLVGFSYQVAN 812

Query: 798 GMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAP 857
           GMEFL  K+CVHRDLAARNVL+  GK+VKICDFGLARDIM DSNY+ +G+  LP+KWMAP
Sbjct: 813 GMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWMAP 872

Query: 858 ESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEE 917
           ES+F  +YT  SDVWS+GILLWEIF+LG  PYP +P++  FY  I+ G++M QP +A++E
Sbjct: 873 ESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDE 932

Query: 918 IYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPH 967
           IY IMQ CW      RP F  L   L   L +  +  YQ VD       H
Sbjct: 933 IYEIMQKCWEEKFEIRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDH 982


>gi|156104876 fms-related tyrosine kinase 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1338

 Score =  338 bits (866), Expect = 2e-92
 Identities = 213/518 (41%), Positives = 299/518 (57%), Gaps = 49/518 (9%)

Query: 442  LAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSSTL 501
            +A +S++   C ++G P P  TW K + K          G+        + G    SSTL
Sbjct: 672  VAISSSTTLDCHANGVPEPQITWFKNNHKIQQ-----EPGI--------ILGP--GSSTL 716

Query: 502  ---NMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCL---LFI 555
                ++E  +G +  C A N  G+   +  L   G     + N+        C+   LF 
Sbjct: 717  FIERVTEEDEG-VYHCKATNQKGSVESSAYLTVQGTSD--KSNLELITLTCTCVAATLFW 773

Query: 556  VVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFR--EYEYDL-KWEFPRENLEF 612
            ++LTL I    +K  R  S+++   ++   D +   +D +     YD  KWEF RE L+ 
Sbjct: 774  LLLTLFI----RKMKRSSSEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKL 829

Query: 613  GKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHE 672
            GK LG GAFGKV+ A+A+GI K+     VAVKMLKE A +SE +ALM+ELK++T +G H 
Sbjct: 830  GKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHL 889

Query: 673  NIVNLLGACTLSG-PIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQS 731
            N+VNLLGACT  G P+ +I EYC YG+L NYL+SKR+ F      + K+      P  + 
Sbjct: 890  NVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFF-----LNKDAALHMEPKKEK 944

Query: 732  HPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLN-----VLTFE 786
                   G +     P  D ++     SF S    E ++   +EEEED +      +T E
Sbjct: 945  MEPGLEQGKK-----PRLDSVTS--SESFASSGFQEDKSLSDVEEEEDSDGFYKEPITME 997

Query: 787  DLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRG 846
            DL+ +++QVA+GMEFL  + C+HRDLAARN+L++   VVKICDFGLARDI  + +YV +G
Sbjct: 998  DLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKG 1057

Query: 847  NARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGF 906
            + RLP+KWMAPES+F+ IY+ KSDVWSYG+LLWEIFSLG +PYPG+ +D +F   ++ G 
Sbjct: 1058 DTRLPLKWMAPESIFDKIYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGM 1117

Query: 907  KMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLG 944
            +M  P Y+T EIY IM  CW  D ++RP F  L   LG
Sbjct: 1118 RMRAPEYSTPEIYQIMLDCWHRDPKERPRFAELVEKLG 1155



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 69/326 (21%), Positives = 112/326 (34%), Gaps = 60/326 (18%)

Query: 265 GEPLWIRCKAVH-VNHGFGLTWELENKALEEGNYFEMSTYSTNRTMIRILFAFVSSVARN 323
           G  L + C A   +N    +TW   ++  +  +       S +   I      +  +   
Sbjct: 245 GHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDKMQNK 304

Query: 324 DTGYYTCSSSKHPSQSAL---VTIVEKGFINATNSSEDY--EIDQYEEFCFSVRFKAYPQ 378
           D G YTC     PS  ++   V I +K FI   +  +     +     +  S++ KA+P 
Sbjct: 305 DKGLYTCRVRSGPSFKSVNTSVHIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVKAFPS 364

Query: 379 IRCTWTFSRKSFPCEQKG---LDNGYSISKFCNHKHQPGEYIFHAENDDAQFTKMF--TL 433
               W   +   P  +K    L  GYS+      +   G Y        +   K    TL
Sbjct: 365 PEVVWL--KDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATL 422

Query: 434 NIRRKPQVLAEA-------------SASQASCFSDGYPLPS--WTWKKCS--------DK 470
            +  KPQ+  +A             S    +C + G P P+  W W  C+        D 
Sbjct: 423 IVNVKPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARCDF 482

Query: 471 SPNCTEEITEGVWNRKANR---------KVFGQWVSSSTLNMSEAIKGFLVKCCAYNSLG 521
             N  E       +   NR          + G+   +STL ++++    +  C A N +G
Sbjct: 483 CSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNKVG 542

Query: 522 TSCETILLNSPGPFPFIQDNISFYAT 547
           T               +  NISFY T
Sbjct: 543 T---------------VGRNISFYIT 553



 Score = 31.2 bits (69), Expect = 5.0
 Identities = 17/78 (21%), Positives = 36/78 (46%), Gaps = 8/78 (10%)

Query: 127 SMVILKMTETQAGEYLLFIQSEATNY------TILFTVS--IRNTLLYTLRRPYFRKMEN 178
           S++I  +TE  AG Y + +  + +N       T++  V   I    + +   P    + +
Sbjct: 389 SLIIKDVTEEDAGNYTILLSIKQSNVFKNLTATLIVNVKPQIYEKAVSSFPDPALYPLGS 448

Query: 179 QDALVCISESVPEPIVEW 196
           +  L C +  +P+P ++W
Sbjct: 449 RQILTCTAYGIPQPTIKW 466


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score =  330 bits (847), Expect = 3e-90
 Identities = 213/561 (37%), Positives = 297/561 (52%), Gaps = 47/561 (8%)

Query: 440  QVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSS 499
            Q  +   + + SC + G P P   W K      N T     G+  +  NR +        
Sbjct: 676  QTTSIGESIEVSCTASGNPPPQIMWFK-----DNETLVEDSGIVLKDGNRNL-------- 722

Query: 500  TLNMSEAIKGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNISFYATIGVCLLFIVVLT 559
            T+         L  C A + LG +         G        I       V  +F  +L 
Sbjct: 723  TIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWLLL 782

Query: 560  LLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDL-KWEFPRENLEFGKVLGS 618
            ++I    K+    E +   + +    D            YD  KWEFPR+ L+ GK LG 
Sbjct: 783  VIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPLGR 842

Query: 619  GAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLL 678
            GAFG+V+ A A+GI KT     VAVKMLKE A  SE  ALMSELK++  +G H N+VNLL
Sbjct: 843  GAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLL 902

Query: 679  GACTL-SGPIYLIFEYCCYGDLLNYLRSKREKF--HRTWTEIFKEHNFSFYPTFQSHPNS 735
            GACT   GP+ +I E+C +G+L  YLRSKR +F  ++T    F++               
Sbjct: 903  GACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQ-------------GK 949

Query: 736  SMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEE---DL--NVLTFEDLLC 790
               G+  V +    D I+    ++  S   +E ++   +EEEE   DL  + LT E L+C
Sbjct: 950  DYVGAIPVDLKRRLDSITSSQSSA--SSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLIC 1007

Query: 791  FAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARL 850
            +++QVAKGMEFL  + C+HRDLAARN+L++   VVKICDFGLARDI  D +YV +G+ARL
Sbjct: 1008 YSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARL 1067

Query: 851  PVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQ 910
            P+KWMAPE++F+ +YTI+SDVWS+G+LLWEIFSLG +PYPG+ +D  F + ++ G +M  
Sbjct: 1068 PLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRA 1127

Query: 911  PFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL-ADAEEAMYQNVDGRVSECPHTY 969
            P Y T E+Y  M  CW  +  +RP+F  L   LG  L A+A++     +   +SE     
Sbjct: 1128 PDYTTPEMYQTMLDCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISE----- 1182

Query: 970  QNRRPFSREMDLGLLSPQAQV 990
                  S E D GL  P + V
Sbjct: 1183 ----TLSMEEDSGLSLPTSPV 1199



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 49/197 (24%), Positives = 73/197 (37%), Gaps = 41/197 (20%)

Query: 262 LKVGEPLWIRCKA-VHVNHGFGLTWE----------LENKALEEGNYFEMSTYSTNRTMI 310
           L VGE L + C A   +N G    WE          L N+ L+  +  EM  + +  T  
Sbjct: 236 LSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLT-- 293

Query: 311 RILFAFVSSVARNDTGYYTCSSSK---HPSQSALVTIVEKGFINATNSSED-YEIDQYEE 366
                 +  V R+D G YTC++S        S  V + EK F+   +  E   E    E 
Sbjct: 294 ------IDGVTRSDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGER 347

Query: 367 FCFSVRFKAYPQIRCTWTFSRKSFPCEQKGLDNGYSISKFCNHKHQPGEYIF---HAEND 423
                ++  YP             P E K   NG  +    NH  + G  +     +E D
Sbjct: 348 VRIPAKYLGYP-------------PPEIKWYKNGIPLES--NHTIKAGHVLTIMEVSERD 392

Query: 424 DAQFTKMFTLNIRRKPQ 440
              +T + T  I ++ Q
Sbjct: 393 TGNYTVILTNPISKEKQ 409


>gi|104294888 fms-related tyrosine kinase 4 isoform 1 precursor [Homo
            sapiens]
          Length = 1363

 Score =  326 bits (836), Expect = 6e-89
 Identities = 191/450 (42%), Positives = 265/450 (58%), Gaps = 20/450 (4%)

Query: 549  GVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDL-KWEFPR 607
            GV  +F  VL LLI    ++    + +   + +                 YD  +WEFPR
Sbjct: 783  GVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPR 842

Query: 608  ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 667
            E L  G+VLG GAFGKV+ A+A+GI K      VAVKMLKE A +SE  ALMSELK++  
Sbjct: 843  ERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIH 902

Query: 668  LGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFY 726
            +G+H N+VNLLGACT   GP+ +I E+C YG+L N+LR+KR+ F     E   E    F 
Sbjct: 903  IGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-SPCAEKSPEQRGRFR 961

Query: 727  PTFQ-SHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTF 785
               + +  +   PGS        SD++  L      +E      +  +  E+  L+ LT 
Sbjct: 962  AMVELARLDRRRPGS--------SDRV--LFARFSKTEGGARRASPDQEAEDLWLSPLTM 1011

Query: 786  EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 845
            EDL+C+++QVA+GMEFL  + C+HRDLAARN+L++   VVKICDFGLARDI  D +YV +
Sbjct: 1012 EDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRK 1071

Query: 846  GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 905
            G+ARLP+KWMAPES+F+ +YT +SDVWS+G+LLWEIFSLG +PYPG+ ++  F + +++G
Sbjct: 1072 GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDG 1131

Query: 906  FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSEC 965
             +M  P  AT  I  IM +CW+ D + RP+F  L   LG    D  +      +  V   
Sbjct: 1132 TRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG----DLLQGRGLQEEEEVCMA 1187

Query: 966  PHTYQNRR--PFSREMDLGLLSPQAQVEDS 993
            P + Q+     FS+   + L   QA  EDS
Sbjct: 1188 PRSSQSSEEGSFSQVSTMALHIAQADAEDS 1217


>gi|103472027 fms-related tyrosine kinase 4 isoform 2 precursor [Homo
            sapiens]
          Length = 1298

 Score =  326 bits (836), Expect = 6e-89
 Identities = 191/450 (42%), Positives = 265/450 (58%), Gaps = 20/450 (4%)

Query: 549  GVCLLFIVVLTLLICHKYKKQFRYESQLQMVQVTGSSDNEYFYVDFREYEYDL-KWEFPR 607
            GV  +F  VL LLI    ++    + +   + +                 YD  +WEFPR
Sbjct: 783  GVIAVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPR 842

Query: 608  ENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMSELKMMTQ 667
            E L  G+VLG GAFGKV+ A+A+GI K      VAVKMLKE A +SE  ALMSELK++  
Sbjct: 843  ERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDTVAVKMLKEGATASEHRALMSELKILIH 902

Query: 668  LGSHENIVNLLGACTL-SGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFY 726
            +G+H N+VNLLGACT   GP+ +I E+C YG+L N+LR+KR+ F     E   E    F 
Sbjct: 903  IGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAF-SPCAEKSPEQRGRFR 961

Query: 727  PTFQ-SHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTF 785
               + +  +   PGS        SD++  L      +E      +  +  E+  L+ LT 
Sbjct: 962  AMVELARLDRRRPGS--------SDRV--LFARFSKTEGGARRASPDQEAEDLWLSPLTM 1011

Query: 786  EDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVR 845
            EDL+C+++QVA+GMEFL  + C+HRDLAARN+L++   VVKICDFGLARDI  D +YV +
Sbjct: 1012 EDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICDFGLARDIYKDPDYVRK 1071

Query: 846  GNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNG 905
            G+ARLP+KWMAPES+F+ +YT +SDVWS+G+LLWEIFSLG +PYPG+ ++  F + +++G
Sbjct: 1072 GSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDG 1131

Query: 906  FKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSEC 965
             +M  P  AT  I  IM +CW+ D + RP+F  L   LG    D  +      +  V   
Sbjct: 1132 TRMRAPELATPAIRRIMLNCWSGDPKARPAFSELVEILG----DLLQGRGLQEEEEVCMA 1187

Query: 966  PHTYQNRR--PFSREMDLGLLSPQAQVEDS 993
            P + Q+     FS+   + L   QA  EDS
Sbjct: 1188 PRSSQSSEEGSFSQVSTMALHIAQADAEDS 1217


>gi|222144241 fibroblast growth factor receptor 2 isoform 8
           precursor [Homo sapiens]
          Length = 704

 Score =  286 bits (731), Expect = 9e-77
 Identities = 187/517 (36%), Positives = 265/517 (51%), Gaps = 104/517 (20%)

Query: 514 CCAYNSLGTSCETI---LLNSPGPFPFIQDN-----ISFYATIGVCLLFIVVLTLLIC-- 563
           C A NS+G S  +    +L +PG    I  +     I+ Y  IGV L+  +V+T+++C  
Sbjct: 227 CLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYC-IGVFLIACMVVTVILCRM 285

Query: 564 ---------------HKYKKQFRYESQLQ------------MVQVT---GSSDNEYFYVD 593
                          HK  K+     Q+             +V++T    S+ +      
Sbjct: 286 KNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAG 345

Query: 594 FREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGV--SIQVAVKMLKEK 649
             EYE   D KWEFPR+ L  GK LG G FG+V+ A A GI K     ++ VAVKMLK+ 
Sbjct: 346 VSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDD 405

Query: 650 ADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREK 709
           A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+I EY   G+L  YLR++R  
Sbjct: 406 ATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP- 464

Query: 710 FHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYE 769
                                       PG                         E  Y+
Sbjct: 465 ----------------------------PGM------------------------EYSYD 472

Query: 770 NQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICD 829
             +  EE+     +TF+DL+   YQ+A+GME+L  + C+HRDLAARNVLVT   V+KI D
Sbjct: 473 INRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIAD 527

Query: 830 FGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPY 889
           FGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +SDVWS+G+L+WEIF+LG +PY
Sbjct: 528 FGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPY 587

Query: 890 PGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLAD 949
           PGIPV+   +KL++ G +MD+P   T E+Y++M+ CW     +RP+F  L   L   L  
Sbjct: 588 PGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTL 646

Query: 950 AEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
                Y ++   + +   +Y + R      D  + SP
Sbjct: 647 TTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 683


>gi|222144237 fibroblast growth factor receptor 2 isoform 6
           precursor [Homo sapiens]
          Length = 706

 Score =  285 bits (730), Expect = 1e-76
 Identities = 187/519 (36%), Positives = 262/519 (50%), Gaps = 106/519 (20%)

Query: 514 CCAYNSLGTSCETI---LLNSPGPFPFIQDN-----ISFYATIGVCLLFIVVLTLLIC-- 563
           C A NS+G S  +    +L +PG    I  +     I+ Y  IGV L+  +V+T+++C  
Sbjct: 227 CLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYC-IGVFLIACMVVTVILCRM 285

Query: 564 ---------------HKYKKQFRYESQLQMVQVTGSSDNEY-----------------FY 591
                          HK  K+     Q+ +   + SS N                     
Sbjct: 286 KNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPML 345

Query: 592 VDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGV--SIQVAVKMLK 647
               EYE   D KWEFPR+ L  GK LG G FG+V+ A A GI K     ++ VAVKMLK
Sbjct: 346 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 405

Query: 648 EKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
           + A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+I EY   G+L  YLR++R
Sbjct: 406 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 465

Query: 708 EKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIE 767
                                         PG                         E  
Sbjct: 466 P-----------------------------PGM------------------------EYS 472

Query: 768 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 827
           Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+HRDLAARNVLVT   V+KI
Sbjct: 473 YDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 527

Query: 828 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 887
            DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +SDVWS+G+L+WEIF+LG +
Sbjct: 528 ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS 587

Query: 888 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL 947
           PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW     +RP+F  L   L   L
Sbjct: 588 PYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 646

Query: 948 ADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
                  Y ++   + +   +Y + R      D  + SP
Sbjct: 647 TLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 685


>gi|222144233 fibroblast growth factor receptor 2 isoform 4
           precursor [Homo sapiens]
          Length = 709

 Score =  285 bits (730), Expect = 1e-76
 Identities = 203/600 (33%), Positives = 290/600 (48%), Gaps = 115/600 (19%)

Query: 432 TLNIRRKPQVLAEASASQASCFSDGYPLPSWTWKKCSDKSPNCTEEITEGVWNRKANRKV 491
           T  + ++   +  A+  +  C + G P+P+  W K      N  E   E   +R    KV
Sbjct: 159 TEKMEKRLHAVPAANTVKFRCPAGGNPMPTMRWLK------NGKEFKQE---HRIGGYKV 209

Query: 492 FGQWVSSSTLNMSEAIKGFLVKCCAYNSLGTSCETILLN--SPGPFPFIQDN-----ISF 544
             Q  S    ++  + KG    C   N  G+   T  L+  +PG    I  +     I+ 
Sbjct: 210 RNQHWSLIMESVVPSDKGNYT-CVVENEYGSINHTYHLDVVAPGREKEITASPDYLEIAI 268

Query: 545 YATIGVCLLFIVVLTLLIC-----------------HKYKKQFRYESQLQMVQVTGSSDN 587
           Y  IGV L+  +V+T+++C                 HK  K+     Q+ +   + SS N
Sbjct: 269 YC-IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMN 327

Query: 588 EY-----------------FYVDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNAT 628
                                    EYE   D KWEFPR+ L  GK LG G FG+V+ A 
Sbjct: 328 SNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAE 387

Query: 629 AYGISKTGV--SIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGP 686
           A GI K     ++ VAVKMLK+ A   +   L+SE++MM  +G H+NI+NLLGACT  GP
Sbjct: 388 AVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGP 447

Query: 687 IYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIH 746
           +Y+I EY   G+L  YLR++R                              PG       
Sbjct: 448 LYVIVEYASKGNLREYLRARRP-----------------------------PGM------ 472

Query: 747 PDSDQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKS 806
                             E  Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + 
Sbjct: 473 ------------------EYSYDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQK 509

Query: 807 CVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYT 866
           C+HRDLAARNVLVT   V+KI DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT
Sbjct: 510 CIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYT 569

Query: 867 IKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCW 926
            +SDVWS+G+L+WEIF+LG +PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW
Sbjct: 570 HQSDVWSFGVLMWEIFTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCW 628

Query: 927 AFDSRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
                +RP+F  L   L   L       Y ++   + +   +Y + R      D  + SP
Sbjct: 629 HAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 688


>gi|221316639 fibroblast growth factor receptor 2 isoform 1
           precursor [Homo sapiens]
          Length = 821

 Score =  285 bits (730), Expect = 1e-76
 Identities = 187/519 (36%), Positives = 262/519 (50%), Gaps = 106/519 (20%)

Query: 514 CCAYNSLGTSCETI---LLNSPGPFPFIQDN-----ISFYATIGVCLLFIVVLTLLIC-- 563
           C A NS+G S  +    +L +PG    I  +     I+ Y  IGV L+  +V+T+++C  
Sbjct: 342 CLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYC-IGVFLIACMVVTVILCRM 400

Query: 564 ---------------HKYKKQFRYESQLQMVQVTGSSDNEY-----------------FY 591
                          HK  K+     Q+ +   + SS N                     
Sbjct: 401 KNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPML 460

Query: 592 VDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGV--SIQVAVKMLK 647
               EYE   D KWEFPR+ L  GK LG G FG+V+ A A GI K     ++ VAVKMLK
Sbjct: 461 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 520

Query: 648 EKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
           + A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+I EY   G+L  YLR++R
Sbjct: 521 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 580

Query: 708 EKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIE 767
                                         PG                         E  
Sbjct: 581 P-----------------------------PGM------------------------EYS 587

Query: 768 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 827
           Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+HRDLAARNVLVT   V+KI
Sbjct: 588 YDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 642

Query: 828 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 887
            DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +SDVWS+G+L+WEIF+LG +
Sbjct: 643 ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS 702

Query: 888 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL 947
           PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW     +RP+F  L   L   L
Sbjct: 703 PYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 761

Query: 948 ADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
                  Y ++   + +   +Y + R      D  + SP
Sbjct: 762 TLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 800


>gi|222144235 fibroblast growth factor receptor 2 isoform 5
           precursor [Homo sapiens]
          Length = 707

 Score =  283 bits (723), Expect = 7e-76
 Identities = 184/495 (37%), Positives = 253/495 (51%), Gaps = 106/495 (21%)

Query: 514 CCAYNSLGTSCETI---LLNSPGPFPFIQDN-----ISFYATIGVCLLFIVVLTLLIC-- 563
           C A NS+G S  +    +L +PG    I  +     I+ Y  IGV L+  +V+T+++C  
Sbjct: 253 CLAGNSIGISFHSAWLTVLPAPGREKEITASPDYLEIAIYC-IGVFLIACMVVTVILCRM 311

Query: 564 ---------------HKYKKQFRYESQLQMVQVTGSSDNEY-----------------FY 591
                          HK  K+     Q+ +   + SS N                     
Sbjct: 312 KNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPML 371

Query: 592 VDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGV--SIQVAVKMLK 647
               EYE   D KWEFPR+ L  GK LG G FG+V+ A A GI K     ++ VAVKMLK
Sbjct: 372 AGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLK 431

Query: 648 EKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
           + A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+I EY   G+L  YLR++R
Sbjct: 432 DDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARR 491

Query: 708 EKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIE 767
                                         PG                         E  
Sbjct: 492 P-----------------------------PGM------------------------EYS 498

Query: 768 YENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKI 827
           Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+HRDLAARNVLVT   V+KI
Sbjct: 499 YDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKI 553

Query: 828 CDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVN 887
            DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +SDVWS+G+L+WEIF+LG +
Sbjct: 554 ADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGS 613

Query: 888 PYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL 947
           PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW     +RP+F  L   L   L
Sbjct: 614 PYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIL 672

Query: 948 ADAEEAMYQNVDGRV 962
                   + V G V
Sbjct: 673 TLTTNEEEKKVSGAV 687


>gi|221316638 fibroblast growth factor receptor 2 isoform 2
           precursor [Homo sapiens]
          Length = 822

 Score =  282 bits (722), Expect = 1e-75
 Identities = 175/477 (36%), Positives = 244/477 (51%), Gaps = 97/477 (20%)

Query: 548 IGVCLLFIVVLTLLIC-----------------HKYKKQFRYESQLQMVQVTGSSDNEY- 589
           IGV L+  +V+T+++C                 HK  K+     Q+ +   + SS N   
Sbjct: 384 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 443

Query: 590 ----------------FYVDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYG 631
                                 EYE   D KWEFPR+ L  GK LG G FG+V+ A A G
Sbjct: 444 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 503

Query: 632 ISKTGV--SIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYL 689
           I K     ++ VAVKMLK+ A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+
Sbjct: 504 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 563

Query: 690 IFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDS 749
           I EY   G+L  YLR++R                              PG          
Sbjct: 564 IVEYASKGNLREYLRARRP-----------------------------PGM--------- 585

Query: 750 DQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 809
                          E  Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+H
Sbjct: 586 ---------------EYSYDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIH 625

Query: 810 RDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKS 869
           RDLAARNVLVT   V+KI DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +S
Sbjct: 626 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 685

Query: 870 DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFD 929
           DVWS+G+L+WEIF+LG +PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW   
Sbjct: 686 DVWSFGVLMWEIFTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 744

Query: 930 SRKRPSFPNLTSFLGCQLADAEEAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
             +RP+F  L   L   L       Y ++   + +   +Y + R      D  + SP
Sbjct: 745 PSQRPTFKQLVEDLDRILTLTTNEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 801


>gi|222144239 fibroblast growth factor receptor 2 isoform 7
           precursor [Homo sapiens]
          Length = 705

 Score =  281 bits (718), Expect = 3e-75
 Identities = 161/395 (40%), Positives = 220/395 (55%), Gaps = 63/395 (15%)

Query: 596 EYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGV--SIQVAVKMLKEKAD 651
           EYE   D KWEFPR+ L  GK LG G FG+V+ A A GI K     ++ VAVKMLK+ A 
Sbjct: 349 EYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDAT 408

Query: 652 SSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFH 711
             +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+I EY   G+L  YLR++R    
Sbjct: 409 EKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP--- 465

Query: 712 RTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQ 771
                                     PG                         E  Y+  
Sbjct: 466 --------------------------PGM------------------------EYSYDIN 475

Query: 772 KRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFG 831
           +  EE+     +TF+DL+   YQ+A+GME+L  + C+HRDLAARNVLVT   V+KI DFG
Sbjct: 476 RVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFG 530

Query: 832 LARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPG 891
           LARDI +   Y    N RLPVKWMAPE+LF+ +YT +SDVWS+G+L+WEIF+LG +PYPG
Sbjct: 531 LARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPG 590

Query: 892 IPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQLADAE 951
           IPV+   +KL++ G +MD+P   T E+Y++M+ CW     +RP+F  L   L   L    
Sbjct: 591 IPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT 649

Query: 952 EAMYQNVDGRVSECPHTYQNRRPFSREMDLGLLSP 986
              Y ++   + +   +Y + R      D  + SP
Sbjct: 650 NEEYLDLSQPLEQYSPSYPDTRSSCSSGDDSVFSP 684


>gi|222144244 fibroblast growth factor receptor 2 isoform 9
           precursor [Homo sapiens]
          Length = 680

 Score =  279 bits (714), Expect = 8e-75
 Identities = 168/434 (38%), Positives = 230/434 (52%), Gaps = 97/434 (22%)

Query: 548 IGVCLLFIVVLTLLIC-----------------HKYKKQFRYESQLQMVQVTGSSDNEY- 589
           IGV L+  +V+T+++C                 HK  K+     Q+ +   + SS N   
Sbjct: 295 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 354

Query: 590 ----------------FYVDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYG 631
                                 EYE   D KWEFPR+ L  GK LG G FG+V+ A A G
Sbjct: 355 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 414

Query: 632 ISKTGV--SIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYL 689
           I K     ++ VAVKMLK+ A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+
Sbjct: 415 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 474

Query: 690 IFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDS 749
           I EY   G+L  YLR++R                              PG          
Sbjct: 475 IVEYASKGNLREYLRARRP-----------------------------PGM--------- 496

Query: 750 DQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 809
                          E  Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+H
Sbjct: 497 ---------------EYSYDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIH 536

Query: 810 RDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKS 869
           RDLAARNVLVT   V+KI DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +S
Sbjct: 537 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 596

Query: 870 DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFD 929
           DVWS+G+L+WEIF+LG +PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW   
Sbjct: 597 DVWSFGVLMWEIFTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 655

Query: 930 SRKRPSFPNLTSFL 943
             +RP+F  L   L
Sbjct: 656 PSQRPTFKQLVEDL 669


>gi|222144231 fibroblast growth factor receptor 2 isoform 3
           precursor [Homo sapiens]
          Length = 769

 Score =  279 bits (714), Expect = 8e-75
 Identities = 168/434 (38%), Positives = 230/434 (52%), Gaps = 97/434 (22%)

Query: 548 IGVCLLFIVVLTLLIC-----------------HKYKKQFRYESQLQMVQVTGSSDNEY- 589
           IGV L+  +V+T+++C                 HK  K+     Q+ +   + SS N   
Sbjct: 384 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 443

Query: 590 ----------------FYVDFREYEY--DLKWEFPRENLEFGKVLGSGAFGKVMNATAYG 631
                                 EYE   D KWEFPR+ L  GK LG G FG+V+ A A G
Sbjct: 444 PLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 503

Query: 632 ISKTGV--SIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYL 689
           I K     ++ VAVKMLK+ A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y+
Sbjct: 504 IDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYV 563

Query: 690 IFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDS 749
           I EY   G+L  YLR++R                              PG          
Sbjct: 564 IVEYASKGNLREYLRARRP-----------------------------PGM--------- 585

Query: 750 DQISGLHGNSFHSEDEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 809
                          E  Y+  +  EE+     +TF+DL+   YQ+A+GME+L  + C+H
Sbjct: 586 ---------------EYSYDINRVPEEQ-----MTFKDLVSCTYQLARGMEYLASQKCIH 625

Query: 810 RDLAARNVLVTHGKVVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKS 869
           RDLAARNVLVT   V+KI DFGLARDI +   Y    N RLPVKWMAPE+LF+ +YT +S
Sbjct: 626 RDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQS 685

Query: 870 DVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFD 929
           DVWS+G+L+WEIF+LG +PYPGIPV+   +KL++ G +MD+P   T E+Y++M+ CW   
Sbjct: 686 DVWSFGVLMWEIFTLGGSPYPGIPVE-ELFKLLKEGHRMDKPANCTNELYMMMRDCWHAV 744

Query: 930 SRKRPSFPNLTSFL 943
             +RP+F  L   L
Sbjct: 745 PSQRPTFKQLVEDL 758


>gi|10862701 ret proto-oncogene isoform c [Homo sapiens]
          Length = 1072

 Score =  255 bits (651), Expect = 2e-67
 Identities = 145/360 (40%), Positives = 200/360 (55%), Gaps = 53/360 (14%)

Query: 584  SSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAV 643
            S +N+     F+  E D KWEFPR+NL  GK LG G FGKV+ ATA+ +        VAV
Sbjct: 699  SMENQVSVDAFKILE-DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAV 757

Query: 644  KMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 703
            KMLKE A  SE   L+SE  ++ Q+ +H +++ L GAC+  GP+ LI EY  YG L  +L
Sbjct: 758  KMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL 816

Query: 704  RSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSE 763
            R  R+                  P +     S    S +   HPD               
Sbjct: 817  RESRK----------------VGPGYLGSGGSRNSSSLD---HPDE-------------- 843

Query: 764  DEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
                               LT  DL+ FA+Q+++GM++L     VHRDLAARN+LV  G+
Sbjct: 844  -----------------RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR 886

Query: 824  VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
             +KI DFGL+RD+  + +YV R   R+PVKWMA ESLF+ IYT +SDVWS+G+LLWEI +
Sbjct: 887  KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 946

Query: 884  LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
            LG NPYPGIP +   + L++ G +M++P   +EE+Y +M  CW  +  KRP F +++  L
Sbjct: 947  LGGNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 1005


>gi|10862703 ret proto-oncogene isoform a [Homo sapiens]
          Length = 1114

 Score =  255 bits (651), Expect = 2e-67
 Identities = 145/360 (40%), Positives = 200/360 (55%), Gaps = 53/360 (14%)

Query: 584  SSDNEYFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAV 643
            S +N+     F+  E D KWEFPR+NL  GK LG G FGKV+ ATA+ +        VAV
Sbjct: 699  SMENQVSVDAFKILE-DPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAV 757

Query: 644  KMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYL 703
            KMLKE A  SE   L+SE  ++ Q+ +H +++ L GAC+  GP+ LI EY  YG L  +L
Sbjct: 758  KMLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFL 816

Query: 704  RSKREKFHRTWTEIFKEHNFSFYPTFQSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSE 763
            R  R+                  P +     S    S +   HPD               
Sbjct: 817  RESRK----------------VGPGYLGSGGSRNSSSLD---HPDE-------------- 843

Query: 764  DEIEYENQKRLEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGK 823
                               LT  DL+ FA+Q+++GM++L     VHRDLAARN+LV  G+
Sbjct: 844  -----------------RALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGR 886

Query: 824  VVKICDFGLARDIMSDSNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFS 883
             +KI DFGL+RD+  + +YV R   R+PVKWMA ESLF+ IYT +SDVWS+G+LLWEI +
Sbjct: 887  KMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVT 946

Query: 884  LGVNPYPGIPVDANFYKLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
            LG NPYPGIP +   + L++ G +M++P   +EE+Y +M  CW  +  KRP F +++  L
Sbjct: 947  LGGNPYPGIPPE-RLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDL 1005


>gi|254028242 fibroblast growth factor receptor 3 isoform 3
           precursor [Homo sapiens]
          Length = 808

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/161 (56%), Positives = 120/161 (74%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           LTF+DL+  AYQVA+GME+L  + C+HRDLAARNVLVT   V+KI DFGLARD+ +   Y
Sbjct: 591 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 650

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ +YT +SDVWS+G+LLWEIF+LG +PYPGIPV+   +KL+
Sbjct: 651 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE-ELFKLL 709

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T ++Y+IM+ CW     +RP+F  L   L
Sbjct: 710 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 750



 Score =  111 bits (277), Expect = 4e-24
 Identities = 107/362 (29%), Positives = 153/362 (42%), Gaps = 80/362 (22%)

Query: 414 GEYIFHAENDDAQFTKMFTLNIRRK----PQVLAEASASQASC-----------FSDGYP 458
           G Y    EN      + +TL++  +    P + A   A+Q +            +SD  P
Sbjct: 224 GNYTCVVENKFGSIRQTYTLDVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQP 283

Query: 459 LPSWTWK---KCSDKSPNCTEEITEGVWNRKANRKVFGQWVSSST--------LNMSEAI 507
              W        S   P+ T  +T           V   W+S S          N+SE  
Sbjct: 284 HIQWLKHVEVNGSKVGPDGTPYVT-----------VLKSWISESVEADVRLRLANVSERD 332

Query: 508 KGFLVKCCAYNSLGTSCETILLNSPGPFPFIQDNI------SFYATI-----GVCLLFIV 556
            G  + C A N +G + +   L+  GP    ++ +      S YA I     G  L  +V
Sbjct: 333 GGEYL-CRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAGSVYAGILSYGVGFFLFILV 391

Query: 557 VLTLLIC---------------HKY-----KKQFRYESQLQM------VQVTGSSDNE-- 588
           V  + +C               HK      K+Q   ES   M      V++   S  E  
Sbjct: 392 VAAVTLCRLRSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGP 451

Query: 589 -YFYVDFREYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVS--IQVAVKM 645
               V   E   D KWE  R  L  GK LG G FG+V+ A A GI K   +  + VAVKM
Sbjct: 452 TLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKM 511

Query: 646 LKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRS 705
           LK+ A   +   L+SE++MM  +G H+NI+NLLGACT  GP+Y++ EY   G+L  +LR+
Sbjct: 512 LKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRA 571

Query: 706 KR 707
           +R
Sbjct: 572 RR 573


>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
           [Homo sapiens]
          Length = 694

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/161 (56%), Positives = 120/161 (74%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           LTF+DL+  AYQVA+GME+L  + C+HRDLAARNVLVT   V+KI DFGLARD+ +   Y
Sbjct: 477 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 536

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ +YT +SDVWS+G+LLWEIF+LG +PYPGIPV+   +KL+
Sbjct: 537 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE-ELFKLL 595

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T ++Y+IM+ CW     +RP+F  L   L
Sbjct: 596 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 636



 Score =  107 bits (268), Expect = 4e-23
 Identities = 54/114 (47%), Positives = 73/114 (64%), Gaps = 2/114 (1%)

Query: 596 EYEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVS--IQVAVKMLKEKADSS 653
           E   D KWE  R  L  GK LG G FG+V+ A A GI K   +  + VAVKMLK+ A   
Sbjct: 346 ELPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDK 405

Query: 654 EREALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
           +   L+SE++MM  +G H+NI+NLLGACT  GP+Y++ EY   G+L  +LR++R
Sbjct: 406 DLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR 459


>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
           [Homo sapiens]
          Length = 806

 Score =  193 bits (491), Expect = 6e-49
 Identities = 91/161 (56%), Positives = 120/161 (74%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           LTF+DL+  AYQVA+GME+L  + C+HRDLAARNVLVT   V+KI DFGLARD+ +   Y
Sbjct: 589 LTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYY 648

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ +YT +SDVWS+G+LLWEIF+LG +PYPGIPV+   +KL+
Sbjct: 649 KKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE-ELFKLL 707

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T ++Y+IM+ CW     +RP+F  L   L
Sbjct: 708 KEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 748



 Score =  108 bits (269), Expect = 3e-23
 Identities = 81/233 (34%), Positives = 112/233 (48%), Gaps = 39/233 (16%)

Query: 514 CCAYNSLGTSCET---ILLNSPGPFPFIQDNISFYATI-----GVCLLFIVVLTLLIC-- 563
           C A NS+G S  +   ++L +        +  S YA I     G  L  +VV  + +C  
Sbjct: 339 CLAGNSIGFSHHSAWLVVLPAEEELVEADEAGSVYAGILSYGVGFFLFILVVAAVTLCRL 398

Query: 564 -------------HKY-----KKQFRYESQLQM------VQVTGSSDNE---YFYVDFRE 596
                        HK      K+Q   ES   M      V++   S  E      V   E
Sbjct: 399 RSPPKKGLGSPTVHKISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELE 458

Query: 597 YEYDLKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVS--IQVAVKMLKEKADSSE 654
              D KWE  R  L  GK LG G FG+V+ A A GI K   +  + VAVKMLK+ A   +
Sbjct: 459 LPADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKD 518

Query: 655 REALMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
              L+SE++MM  +G H+NI+NLLGACT  GP+Y++ EY   G+L  +LR++R
Sbjct: 519 LSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARR 571


>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
           [Homo sapiens]
          Length = 731

 Score =  190 bits (482), Expect = 7e-48
 Identities = 91/161 (56%), Positives = 118/161 (73%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           L+ +DL+  AYQVA+GME+L  K C+HRDLAARNVLVT   V+KI DFGLARDI     Y
Sbjct: 504 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 563

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ IYT +SDVWS+G+LLWEIF+LG +PYPG+PV+   +KL+
Sbjct: 564 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE-ELFKLL 622

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T E+Y++M+ CW     +RP+F  L   L
Sbjct: 623 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 663


>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
           [Homo sapiens]
          Length = 733

 Score =  190 bits (482), Expect = 7e-48
 Identities = 91/161 (56%), Positives = 118/161 (73%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           L+ +DL+  AYQVA+GME+L  K C+HRDLAARNVLVT   V+KI DFGLARDI     Y
Sbjct: 506 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 565

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ IYT +SDVWS+G+LLWEIF+LG +PYPG+PV+   +KL+
Sbjct: 566 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE-ELFKLL 624

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T E+Y++M+ CW     +RP+F  L   L
Sbjct: 625 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 665


>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
           [Homo sapiens]
          Length = 820

 Score =  190 bits (482), Expect = 7e-48
 Identities = 91/161 (56%), Positives = 118/161 (73%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           L+ +DL+  AYQVA+GME+L  K C+HRDLAARNVLVT   V+KI DFGLARDI     Y
Sbjct: 593 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 652

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ IYT +SDVWS+G+LLWEIF+LG +PYPG+PV+   +KL+
Sbjct: 653 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE-ELFKLL 711

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T E+Y++M+ CW     +RP+F  L   L
Sbjct: 712 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 752


>gi|105990522 fibroblast growth factor receptor 1 isoform 1
           precursor [Homo sapiens]
          Length = 822

 Score =  190 bits (482), Expect = 7e-48
 Identities = 91/161 (56%), Positives = 118/161 (73%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           L+ +DL+  AYQVA+GME+L  K C+HRDLAARNVLVT   V+KI DFGLARDI     Y
Sbjct: 595 LSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYY 654

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ IYT +SDVWS+G+LLWEIF+LG +PYPG+PV+   +KL+
Sbjct: 655 KKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVE-ELFKLL 713

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P   T E+Y++M+ CW     +RP+F  L   L
Sbjct: 714 KEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL 754


>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
            domains 1 [Homo sapiens]
          Length = 1138

 Score =  186 bits (473), Expect = 7e-47
 Identities = 122/348 (35%), Positives = 175/348 (50%), Gaps = 71/348 (20%)

Query: 601  LKWEFPRENLEFGKVLGSGAFGKVMNATAYGISKTGVSIQVAVKMLKEKADSSEREALMS 660
            L+WE    ++ F  ++G G FG+V+ A    I K G+ +  A+KMLKE A  ++      
Sbjct: 834  LEWE----DITFEDLIGEGNFGQVIRAM---IKKDGLKMNAAIKMLKEYASENDHRDFAG 886

Query: 661  ELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKE 720
            EL+++ +LG H NI+NLLGAC   G +Y+  EY  YG+LL++LR  R             
Sbjct: 887  ELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRV------------ 934

Query: 721  HNFSFYPTF-QSHPNSSMPGSREVQIHPDSDQISGLHGNSFHSEDEIEYENQKRLEEEED 779
                  P F + H  +S   SR++ +   SD  +G+           +Y ++K+      
Sbjct: 935  --LETDPAFAREHGTASTLSSRQL-LRFASDAANGM-----------QYLSEKQF----- 975

Query: 780  LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSD 839
                                        +HRDLAARNVLV      KI DFGL+R    +
Sbjct: 976  ----------------------------IHRDLAARNVLVGENLASKIADFGLSR---GE 1004

Query: 840  SNYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFY 899
              YV +   RLPV+WMA ESL   +YT KSDVWS+G+LLWEI SLG  PY G+   A  Y
Sbjct: 1005 EVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTC-AELY 1063

Query: 900  KLIQNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFLGCQL 947
            + +  G++M+QP    +E+Y +M+ CW     +RP F  +   LG  L
Sbjct: 1064 EKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRML 1111


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  182 bits (462), Expect = 1e-45
 Identities = 87/161 (54%), Positives = 115/161 (71%), Gaps = 1/161 (0%)

Query: 783 LTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDIMSDSNY 842
           L+F  L+  AYQVA+GM++LE + C+HRDLAARNVLVT   V+KI DFGLAR +     Y
Sbjct: 544 LSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYY 603

Query: 843 VVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLI 902
               N RLPVKWMAPE+LF+ +YT +SDVWS+GILLWEIF+LG +PYPGIPV+   + L+
Sbjct: 604 KKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVE-ELFSLL 662

Query: 903 QNGFKMDQPFYATEEIYIIMQSCWAFDSRKRPSFPNLTSFL 943
           + G +MD+P +   E+Y +M+ CW     +RP+F  L   L
Sbjct: 663 REGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEAL 703



 Score =  102 bits (254), Expect = 2e-21
 Identities = 50/110 (45%), Positives = 73/110 (66%), Gaps = 2/110 (1%)

Query: 600 DLKWEFPRENLEFGKVLGSGAFGKVMNATAYGI--SKTGVSIQVAVKMLKEKADSSEREA 657
           D  WEFPR+ L  GK LG G FG+V+ A A+G+  ++   +  VAVKMLK+ A   +   
Sbjct: 417 DPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLAD 476

Query: 658 LMSELKMMTQLGSHENIVNLLGACTLSGPIYLIFEYCCYGDLLNYLRSKR 707
           L+SE+++M  +G H+NI+NLLG CT  GP+Y+I E    G+L  +LR++R
Sbjct: 477 LVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARR 526


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,173,205
Number of Sequences: 37866
Number of extensions: 1709416
Number of successful extensions: 7244
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 513
Number of HSP's successfully gapped in prelim test: 284
Number of HSP's that attempted gapping in prelim test: 4701
Number of HSP's gapped (non-prelim): 1921
length of query: 993
length of database: 18,247,518
effective HSP length: 112
effective length of query: 881
effective length of database: 14,006,526
effective search space: 12339749406
effective search space used: 12339749406
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.