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Search of human proteins with 24308179
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
(639 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 1249 0.0
gi|16975496 cortactin binding protein 2 [Homo sapiens] 384 e-106
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 151 2e-36
gi|109659847 filamin A interacting protein 1-like isoform 3 [Hom... 145 1e-34
gi|109659845 filamin A interacting protein 1-like isoform 1 [Hom... 145 1e-34
gi|109659849 filamin A interacting protein 1-like isoform 2 [Hom... 76 8e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 70 6e-12
gi|4503593 epidermal growth factor receptor pathway substrate 15... 69 2e-11
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 66 9e-11
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 66 9e-11
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 65 2e-10
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 64 6e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 64 6e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 64 6e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 64 6e-10
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 64 6e-10
gi|229577185 epidermal growth factor receptor pathway substrate ... 62 1e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 62 2e-09
gi|81295809 pericentrin [Homo sapiens] 61 3e-09
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 61 3e-09
gi|148746195 trichohyalin [Homo sapiens] 61 4e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 61 4e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 60 5e-09
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 60 6e-09
gi|33946313 ninein isoform 4 [Homo sapiens] 60 8e-09
gi|33946321 ninein isoform 5 [Homo sapiens] 60 8e-09
gi|148536871 ninein isoform 1 [Homo sapiens] 60 8e-09
gi|148536869 ninein isoform 2 [Homo sapiens] 60 8e-09
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 59 1e-08
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 59 1e-08
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 1249 bits (3232), Expect = 0.0
Identities = 639/639 (100%), Positives = 639/639 (100%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD
Sbjct: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
Query: 61 FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQ 120
FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQ
Sbjct: 61 FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQ 120
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSS 180
RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSS
Sbjct: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSS 180
Query: 181 MLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLS 240
MLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLS
Sbjct: 181 MLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLS 240
Query: 241 EFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGT 300
EFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGT
Sbjct: 241 EFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGT 300
Query: 301 ATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTR 360
ATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTR
Sbjct: 301 ATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTR 360
Query: 361 ELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTAS 420
ELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTAS
Sbjct: 361 ELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSLSPSSTAS 420
Query: 421 SSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQ 480
SSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQ
Sbjct: 421 SSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQADQDQQASGLQ 480
Query: 481 SPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTA 540
SPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTA
Sbjct: 481 SPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQGPIKPVSPNSSPFGTDYRNLANTA 540
Query: 541 NPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLT 600
NPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLT
Sbjct: 541 NPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLTPSPSATTPLT 600
Query: 601 KTHSQAASLTTAEDLASSCSSNTVVANGKDVELLLPTSS 639
KTHSQAASLTTAEDLASSCSSNTVVANGKDVELLLPTSS
Sbjct: 601 KTHSQAASLTTAEDLASSCSSNTVVANGKDVELLLPTSS 639
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 384 bits (985), Expect = e-106
Identities = 259/654 (39%), Positives = 347/654 (53%), Gaps = 94/654 (14%)
Query: 2 NLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDF 61
+++ LSK EL L S++EGELEARDLVIEAL+A+ ++ FI+ERYG++N++DP +ALQRD+
Sbjct: 32 DVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDY 91
Query: 62 ETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQR 121
E D EK+PVCTNPLSIL+ VM CK MQERM +QLAAAESR +K
Sbjct: 92 EA--GAGDKEKKPVCTNPLSILEAVMAHCKKMQERMSAQLAAAESRQKK----------- 138
Query: 122 HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSM 181
LE EK Q++ E+E KKL+++LEEER ++KQ+ M
Sbjct: 139 -------------------------LEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLM 173
Query: 182 LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSE 241
LV ECK+ + K EE QK ++ KLE+EK + ++LEEEL+AE++R + EAQ+EKQLSE
Sbjct: 174 LVKECKQLSGKVIEEAQKLEDVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSE 233
Query: 242 FDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV----TVS 297
FD EREQLRAKLNREE T LKEE++ ++K+++ L+ S P+ L + VS
Sbjct: 234 FDTEREQLRAKLNREEAHTTDLKEEIDKMRKMIEQLKRG-SDSKPSLSLPRKTKDRRLVS 292
Query: 298 KGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQ 357
TE + SV CQT+ H + +T P +P S C
Sbjct: 293 ISVGTEGTVTRSVACQTDLVTENADHMKKL-PLTMPVKPSTGSPLVSANAKGSVCTSATM 351
Query: 358 T----TRELTAGNNVENQVPPREKSVALAQEKPVENGGCPVGIETPVPMPSPLSSSGSSL 413
R+ + G+ + VP A K ENG P PL S+
Sbjct: 352 ARPGIDRQASYGDLIGASVPAFPPPSA---NKIEENGPSTGSTPDPTSSTPPLPSNA--- 405
Query: 414 SPSSTASSSLTSSPCSSPVLTKRLLGSSASSPGYQSSYQVGINQRFHAARHKFQSQA-DQ 472
+P + + + +P + S SP +S G+N R AAR +FQ A D
Sbjct: 406 APPTAQTPGIAPQNSQAPPM------HSLHSPCANTSLHPGLNPRIQAARFRFQGNANDP 459
Query: 473 DQQASGLQSPPSRDLSPTLIDNSAAKQLARNTVTQVLSRFTSQQ--GPIKPVSPNSSPFG 530
DQ + QSPPSRD+SPT DN AKQLARNTVTQ LSRFTS Q P +P P
Sbjct: 460 DQNGNTTQSPPSRDVSPTSRDNLVAKQLARNTVTQALSRFTSPQAGAPSRPGVP------ 513
Query: 531 TDYRNLANTANPRGDTSHSPTPGKVSSPLSPLSPGIKSPTIPRAERGNPPPIPPKKPGLT 590
P GD P G+ S +K+ + R +RGNPPPIPPKKPGL+
Sbjct: 514 -----------PTGDVGTHPPVGRTS---------LKTHGVARVDRGNPPPIPPKKPGLS 553
Query: 591 PSPSATTPLTKT---HSQAASLTTAEDLASSCSSNTVVANGKDV--ELLLPTSS 639
+PS P K S+A++ D + S+ + + G V E LP SS
Sbjct: 554 QTPSPPHPQLKVIIDSSRASNTGAKVDNKTVASTPSSLPQGNRVINEENLPKSS 607
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 151 bits (381), Expect = 2e-36
Identities = 94/286 (32%), Positives = 158/286 (55%), Gaps = 3/286 (1%)
Query: 5 KLSKPELLTLFSILEGELEARDLVIEALKAQH-RDTFIEERYGKYNISDPLMALQRDFET 63
+LSK +L+ L SI+EGEL+AR+ VI LK + + +E YG L L RD
Sbjct: 74 ELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAIL 133
Query: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHA 123
+EK+ GE V P+S L + ++ K RML QL AE HR+ + +LE E+ +H
Sbjct: 134 AQEKSIGED--VYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHT 191
Query: 124 QDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV 183
+ DD T +LE+ERERL + LE EK+ + EKE K ++L +E + K + MLV
Sbjct: 192 DYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLV 251
Query: 184 LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFD 243
E + + + QK +L+ KL +E+ ++ + + +R++ L+ E E + S F
Sbjct: 252 DERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFS 311
Query: 244 IEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQ 289
E E++ AKL +E+ + L+ ++ L + +++LE ++++ E+
Sbjct: 312 QEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEE 357
Score = 72.0 bits (175), Expect = 2e-12
Identities = 51/202 (25%), Positives = 106/202 (52%), Gaps = 12/202 (5%)
Query: 89 QCKNMQERMLSQ------LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER-- 140
QC+ +++++ + L + +K + +LE+ + ++ +E + LEKE+
Sbjct: 403 QCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNL 462
Query: 141 -ERLTQQLEFEKSQVKKFEKEQKKLSS---QLEEERSRHKQLSSMLVLECKKATNKAAEE 196
+ L +LE KS+VK+ E + +L L+++ ++ K + MLV E K K +E
Sbjct: 463 TKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQE 522
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
+K L+ + E+ +V + E+L E K+ L+ ++++E+++ ER++L KL E
Sbjct: 523 ERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSE 582
Query: 257 ENRTKTLKEEMESLKKIVKDLE 278
E ++ L ++ LKK + +E
Sbjct: 583 EEKSSELSCSVDLLKKRLDGIE 604
Score = 60.1 bits (144), Expect = 6e-09
Identities = 83/318 (26%), Positives = 141/318 (44%), Gaps = 42/318 (13%)
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV-LECKKA 189
++T +E+ ++RL QQLE + + K E E +L + E+ + LS L ++ + A
Sbjct: 631 ELTLEIERLKKRL-QQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIA 689
Query: 190 TNKAAEEGQKAGELS-----LKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI 244
NKA E+G+ + + +LE+ KSR K E + E+ L + E QLS+ +
Sbjct: 690 KNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNK---EDQLSQLQV 746
Query: 245 EREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHS-------SPNEQLKKPVTVS 297
+ L+ + EEN+ K + +E+ +L K+LE S ++S + + PVT S
Sbjct: 747 DYSVLQQRFMEEENKNKNMGQEVLNL---TKELELSKRYSRALRPSVNGRRMVDVPVT-S 802
Query: 298 KGTATEPLM-------LMSVFCQTESFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNG 350
G T+ + +VF + +SF E SN+ ++ GL P + +
Sbjct: 803 TGVQTDAVSGEAAEEETPAVFIR-KSFQEENHIMSNLRQV---GLKKP-------VERSS 851
Query: 351 HCDPEIQTTRELTAGNNVENQVPPREKSVALAQEK-PVENG--GCPVGIETPVPMPSPLS 407
D ELT + + RE ++ QEK P N G P + PL
Sbjct: 852 VLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLH 911
Query: 408 SSGSSLSPSSTASSSLTS 425
+ +STA+ +TS
Sbjct: 912 IRVTPDHENSTATLEITS 929
Score = 57.4 bits (137), Expect = 4e-08
Identities = 72/310 (23%), Positives = 142/310 (45%), Gaps = 38/310 (12%)
Query: 21 ELEARDLVIEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDG--EKQPV 75
E+E +D I ++Q R+ EE + + + LQ+ L++ + + +
Sbjct: 389 EMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSE 448
Query: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGD----- 130
CT L + +++ KN+ + +L++L +SR ++ L+ E R A+ + + D
Sbjct: 449 CTQ----LHLNLEKEKNLTKDLLNELEVVKSRVKE--LECSESRLEKAELSLKDDLTKLK 502
Query: 131 DVTYMLEKERERLTQQLEFEKSQV----KKFEKEQKKL----SSQLEEERSRHKQLSSM- 181
T ML ER+ + ++++ E+ +V K F+ EQ K+ +EE + K S M
Sbjct: 503 SFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEME 562
Query: 182 -----LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEE---ELAAERKR-GLQTE 232
L E + K E +K+ ELS ++ K R+ +EE E+ R R G +
Sbjct: 563 EKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELT 622
Query: 233 AQVEKQLSEFDIEREQLRAKLNR----EENRTKTLKEEMESLKKIVKDLEASHQHSSPNE 288
+ ++ E +E E+L+ +L + E + KT E + +K + + ++ S E
Sbjct: 623 CPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLE 682
Query: 289 QLKKPVTVSK 298
++K + +K
Sbjct: 683 EIKHQIAKNK 692
>gi|109659847 filamin A interacting protein 1-like isoform 3 [Homo
sapiens]
Length = 1133
Score = 145 bits (366), Expect = 1e-34
Identities = 90/299 (30%), Positives = 174/299 (58%), Gaps = 5/299 (1%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRD-TFIEERYGKYNISDPLMALQRDFE 62
E LS+ +LL L SILEGEL+ARD VI LKA+ D +E +YG L ALQRD
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD-- 122
Query: 63 TLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRH 122
+ K+ ++ + P++ L V+++ K R+L QL AE R+ IL+LEEE+++H
Sbjct: 123 AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
Query: 123 AQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSML 182
+ + D+ +LE+E ERL + ++ E ++ E+E++K + L+EE ++ K + M+
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 183 VLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
V E ++ T + + QK EL+ ++ ++++ E + E ++ + E +++ Q ++F
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 302
Query: 243 DIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV--TVSKG 299
+++ + AKL E+++ + L++++ +L + + +LE +++ E+ + + +SKG
Sbjct: 303 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
Score = 76.3 bits (186), Expect = 8e-14
Identities = 61/230 (26%), Positives = 115/230 (50%), Gaps = 17/230 (7%)
Query: 88 KQCKNMQERMLSQLAAAES------RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER- 140
+QC+++ +R+ + ++ + K I+ LE+ + E + LEKER
Sbjct: 394 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
Query: 141 --ERLTQQLEFEKSQVKKFEKEQKKLSSQ---LEEERSRHKQLSSMLVLECKKATNKAAE 195
++L+Q+LE K ++K+ E + +L L+E+ ++ K L+ M V E K + K +
Sbjct: 454 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 513
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
K S +L+ E+++V+ + E+L E KR L+++ VE+++ ER+ L+ KL
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPL 305
EE + L + LK ++ LEA + + LK + G +T L
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEK-----DFLKNKLNQDSGKSTTAL 618
Score = 52.8 bits (125), Expect = 1e-06
Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 22/319 (6%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYN-ISDPLMALQRDFE 62
E L+K + LT+ + E + + L K Q + ++ K +++ L ++
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL--IEETKR 545
Query: 63 TLKEKND-GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV-ILDLEEERQ 120
LK K D EK T LK +K + +LS++ ++R + + ++ + +
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK----------KFEKEQKKLSSQLEE 170
+ QD+ + + + + L+Q++E K ++K K E E + L +
Sbjct: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 171 ERSRHKQLSSMLV-LECKKATNKAAEEGQKAGE--LSLKLEKEKSRVSKLEEELAAERKR 227
ER + + LS L ++ + A K AE+ + + E L +L++E+++ L E+ A +++
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
Query: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIV---KDLEASHQHS 284
+ E + + L+ KLN++ENR + L E+E+L K + + S + S
Sbjct: 726 -IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
Query: 285 SPNEQLKKPVTVSKGTATE 303
++ P SK TE
Sbjct: 785 LNGRRISDPQVFSKEVQTE 803
>gi|109659845 filamin A interacting protein 1-like isoform 1 [Homo
sapiens]
Length = 1135
Score = 145 bits (366), Expect = 1e-34
Identities = 90/299 (30%), Positives = 174/299 (58%), Gaps = 5/299 (1%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRD-TFIEERYGKYNISDPLMALQRDFE 62
E LS+ +LL L SILEGEL+ARD VI LKA+ D +E +YG L ALQRD
Sbjct: 65 EDLSRDDLLFLLSILEGELQARDEVIGILKAEKMDLALLEAQYGFVTPKKVLEALQRD-- 122
Query: 63 TLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRH 122
+ K+ ++ + P++ L V+++ K R+L QL AE R+ IL+LEEE+++H
Sbjct: 123 AFQAKSTPWQEDIYEKPMNELDKVVEKHKESYRRILGQLLVAEKSRRQTILELEEEKRKH 182
Query: 123 AQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSML 182
+ + D+ +LE+E ERL + ++ E ++ E+E++K + L+EE ++ K + M+
Sbjct: 183 KEYMEKSDEFICLLEQECERLKKLIDQEIKSQEEKEQEKEKRVTTLKEELTKLKSFALMV 242
Query: 183 VLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
V E ++ T + + QK EL+ ++ ++++ E + E ++ + E +++ Q ++F
Sbjct: 243 VDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTTKF 302
Query: 243 DIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV--TVSKG 299
+++ + AKL E+++ + L++++ +L + + +LE +++ E+ + + +SKG
Sbjct: 303 HQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISKG 361
Score = 76.3 bits (186), Expect = 8e-14
Identities = 61/230 (26%), Positives = 115/230 (50%), Gaps = 17/230 (7%)
Query: 88 KQCKNMQERMLSQLAAAES------RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER- 140
+QC+++ +R+ + ++ + K I+ LE+ + E + LEKER
Sbjct: 394 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 453
Query: 141 --ERLTQQLEFEKSQVKKFEKEQKKLSSQ---LEEERSRHKQLSSMLVLECKKATNKAAE 195
++L+Q+LE K ++K+ E + +L L+E+ ++ K L+ M V E K + K +
Sbjct: 454 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 513
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
K S +L+ E+++V+ + E+L E KR L+++ VE+++ ER+ L+ KL
Sbjct: 514 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 573
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPL 305
EE + L + LK ++ LEA + + LK + G +T L
Sbjct: 574 EEEKGNDLLSRVNMLKNRLQSLEAIEK-----DFLKNKLNQDSGKSTTAL 618
Score = 52.8 bits (125), Expect = 1e-06
Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 22/319 (6%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYN-ISDPLMALQRDFE 62
E L+K + LT+ + E + + L K Q + ++ K +++ L ++
Sbjct: 488 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL--IEETKR 545
Query: 63 TLKEKND-GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV-ILDLEEERQ 120
LK K D EK T LK +K + +LS++ ++R + + ++ + +
Sbjct: 546 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 605
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK----------KFEKEQKKLSSQLEE 170
+ QD+ + + + + L+Q++E K ++K K E E + L +
Sbjct: 606 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 665
Query: 171 ERSRHKQLSSMLV-LECKKATNKAAEEGQKAGE--LSLKLEKEKSRVSKLEEELAAERKR 227
ER + + LS L ++ + A K AE+ + + E L +L++E+++ L E+ A +++
Sbjct: 666 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 725
Query: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIV---KDLEASHQHS 284
+ E + + L+ KLN++ENR + L E+E+L K + + S + S
Sbjct: 726 -IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 784
Query: 285 SPNEQLKKPVTVSKGTATE 303
++ P SK TE
Sbjct: 785 LNGRRISDPQVFSKEVQTE 803
>gi|109659849 filamin A interacting protein 1-like isoform 2 [Homo
sapiens]
Length = 893
Score = 76.3 bits (186), Expect = 8e-14
Identities = 61/230 (26%), Positives = 115/230 (50%), Gaps = 17/230 (7%)
Query: 88 KQCKNMQERMLSQLAAAES------RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER- 140
+QC+++ +R+ + ++ + K I+ LE+ + E + LEKER
Sbjct: 154 EQCRDLNKRLERETLQSKDFKLEVEKLSKRIMALEKLEDAFNKSKQECYSLKCNLEKERM 213
Query: 141 --ERLTQQLEFEKSQVKKFEKEQKKLSSQ---LEEERSRHKQLSSMLVLECKKATNKAAE 195
++L+Q+LE K ++K+ E + +L L+E+ ++ K L+ M V E K + K +
Sbjct: 214 TTKQLSQELESLKVRIKELEAIESRLEKTEFTLKEDLTKLKTLTVMFVDERKTMSEKLKK 273
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
K S +L+ E+++V+ + E+L E KR L+++ VE+++ ER+ L+ KL
Sbjct: 274 TEDKLQAASSQLQVEQNKVTTVTEKLIEETKRALKSKTDVEEKMYSVTKERDDLKNKLKA 333
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPL 305
EE + L + LK ++ LEA + + LK + G +T L
Sbjct: 334 EEEKGNDLLSRVNMLKNRLQSLEAIEK-----DFLKNKLNQDSGKSTTAL 378
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/194 (25%), Positives = 92/194 (47%), Gaps = 20/194 (10%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
Q+R+ +QL + +++ + +E + A A +++E ++ T+ + ++Q
Sbjct: 6 QQRLTAQLTLQRQKIQELTTNAKETHTKLALAEAR-------VQEEEQKATRLEKELQTQ 58
Query: 154 VKKFEKEQKKLSSQLEEERSRHKQLSSMLVL---------ECKKATNKAAEEGQKAGELS 204
KF ++Q + ++L E S+++QL L E ++ KA EE Q E
Sbjct: 59 TTKFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKI 118
Query: 205 LKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLK 264
K E + + EEL RKR L E + +++L + + + L +L RE ++K K
Sbjct: 119 SKGEYGNAGIMAEVEEL---RKRVLDMEGK-DEELIKMEEQCRDLNKRLERETLQSKDFK 174
Query: 265 EEMESLKKIVKDLE 278
E+E L K + LE
Sbjct: 175 LEVEKLSKRIMALE 188
Score = 52.8 bits (125), Expect = 1e-06
Identities = 71/319 (22%), Positives = 143/319 (44%), Gaps = 22/319 (6%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYN-ISDPLMALQRDFE 62
E L+K + LT+ + E + + L K Q + ++ K +++ L ++
Sbjct: 248 EDLTKLKTLTVMFVDERKTMSEKLKKTEDKLQAASSQLQVEQNKVTTVTEKL--IEETKR 305
Query: 63 TLKEKND-GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV-ILDLEEERQ 120
LK K D EK T LK +K + +LS++ ++R + + ++ + +
Sbjct: 306 ALKSKTDVEEKMYSVTKERDDLKNKLKAEEEKGNDLLSRVNMLKNRLQSLEAIEKDFLKN 365
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK----------KFEKEQKKLSSQLEE 170
+ QD+ + + + + L+Q++E K ++K K E E + L +
Sbjct: 366 KLNQDSGKSTTALHQENNKIKELSQEVERLKLKLKDMKAIEDDLMKTEDEYETLERRYAN 425
Query: 171 ERSRHKQLSSMLV-LECKKATNKAAEEGQKAGE--LSLKLEKEKSRVSKLEEELAAERKR 227
ER + + LS L ++ + A K AE+ + + E L +L++E+++ L E+ A +++
Sbjct: 426 ERDKAQFLSKELEHVKMELAKYKLAEKTETSHEQWLFKRLQEEEAKSGHLSREVDALKEK 485
Query: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIV---KDLEASHQHS 284
+ E + + L+ KLN++ENR + L E+E+L K + + S + S
Sbjct: 486 -IHEYMATEDLICHLQGDHSVLQKKLNQQENRNRDLGREIENLTKELERYRHFSKSLRPS 544
Query: 285 SPNEQLKKPVTVSKGTATE 303
++ P SK TE
Sbjct: 545 LNGRRISDPQVFSKEVQTE 563
Score = 48.1 bits (113), Expect = 2e-05
Identities = 32/148 (21%), Positives = 72/148 (48%), Gaps = 1/148 (0%)
Query: 135 MLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAA 194
M+ E++RLT QL ++ ++++ K+ ++L +R ++ K+ +
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
Query: 195 EEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLN 254
+ Q + KL E S+ +L+++LAA R + + + L + + E + ++ K++
Sbjct: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAA-LSRQIDELEETNRSLRKAEEELQDIKEKIS 119
Query: 255 REENRTKTLKEEMESLKKIVKDLEASHQ 282
+ E + E+E L+K V D+E +
Sbjct: 120 KGEYGNAGIMAEVEELRKRVLDMEGKDE 147
Score = 47.4 bits (111), Expect = 4e-05
Identities = 25/121 (20%), Positives = 69/121 (57%), Gaps = 2/121 (1%)
Query: 181 MLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLS 240
M+V E ++ T + + QK EL+ ++ ++++ E + E ++ + E +++ Q +
Sbjct: 1 MVVDEQQRLTAQLTLQRQKIQELTTNAKETHTKLALAEARVQEEEQKATRLEKELQTQTT 60
Query: 241 EFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV--TVSK 298
+F +++ + AKL E+++ + L++++ +L + + +LE +++ E+ + + +SK
Sbjct: 61 KFHQDQDTIMAKLTNEDSQNRQLQQKLAALSRQIDELEETNRSLRKAEEELQDIKEKISK 120
Query: 299 G 299
G
Sbjct: 121 G 121
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 70.1 bits (170), Expect = 6e-12
Identities = 66/267 (24%), Positives = 124/267 (46%), Gaps = 23/267 (8%)
Query: 31 ALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV--CTNPLSILKV 85
AL++Q +DT EE K ++S L ++ + + +E+ + E++ ++ L
Sbjct: 1305 ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 86 VMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQ 145
+ K E + L AE RK+ DLE QRH + A D LEK + RL Q
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDK----LEKTKTRLQQ 1420
Query: 146 QLE-------FEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQ 198
+L+ ++ EK+QKK L EE K +S+ E +A +A E+
Sbjct: 1421 ELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEE----KTISAKYAEERDRAEAEAREKET 1476
Query: 199 KAGELSLKLE---KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
KA L+ LE ++K+ + +L ++ E + + ++ V K + E + + L ++
Sbjct: 1477 KALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE 1536
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + + L++E+++ + LE + Q
Sbjct: 1537 MKTQLEELEDELQATEDAKLRLEVNLQ 1563
Score = 63.5 bits (153), Expect = 6e-10
Identities = 74/324 (22%), Positives = 148/324 (45%), Gaps = 29/324 (8%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFET 63
++L+ LT L+ +L A L ++ + E + ++ L+
Sbjct: 860 KQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHD 919
Query: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILD---LEEERQ 120
L+ + + E++ C + L K M+Q N+QE + QL ES +K+ L+ E + +
Sbjct: 920 LEARVEEEEER-CQH-LQAEKKKMQQ--NIQE-LEEQLEEEESARQKLQLEKVTTEAKLK 974
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQL---------EFEKSQ-VKKFEKEQKKLSSQLEE 170
+ ++ +D L KE++ L ++ E EKS+ + K + + + + + LEE
Sbjct: 975 KLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034
Query: 171 ERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL--------- 221
R ++ L +K + + + EL ++ + K +++K EEEL
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094
Query: 222 -AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD-LEA 279
AA++ L+ ++E Q+SE + E RA N+ E + + L EE+E+LK ++D L++
Sbjct: 1095 EAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDS 1154
Query: 280 SHQHSSPNEQLKKPVTVSKGTATE 303
+ + ++ V + K T E
Sbjct: 1155 TAAQQELRSKREQEVNILKKTLEE 1178
Score = 54.3 bits (129), Expect = 3e-07
Identities = 63/294 (21%), Positives = 127/294 (43%), Gaps = 28/294 (9%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
M L+K+ EL + S L+ +LE+ + Q RD E K + D L +
Sbjct: 1101 MALKKIR--ELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ 1158
Query: 61 FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQ 120
E L+ K + E ++ILK +++ E + ++ +H + + +L E+ +
Sbjct: 1159 QE-LRSKREQE--------VNILKKTLEEEAKTHEAQIQEM---RQKHSQAVEELAEQLE 1206
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE--------ER 172
+ + A + LE ER L +++ E ++KK+ +QL+E ER
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGER 1266
Query: 173 SRHKQLSSM--LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQ 230
R + + L +E T ++ K+ +L+ +S++ +E L E ++ L
Sbjct: 1267 VRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL- 1325
Query: 231 TEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHS 284
+ +L + + E+ R +L EE L++++ +L V D++ + S
Sbjct: 1326 ---SLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDS 1376
Score = 53.9 bits (128), Expect = 4e-07
Identities = 56/226 (24%), Positives = 101/226 (44%), Gaps = 8/226 (3%)
Query: 49 NISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRH 108
++SD + LQ LK + +K+ L+ ++ Q KNM + + +L ES+
Sbjct: 1059 DLSDQIAELQAQIAELKMQL-AKKEEELQAALARVEEEAAQ-KNMALKKIREL---ESQI 1113
Query: 109 RKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK---KFEKEQKKLS 165
++ DLE ER + + D+ LE + L L+ +Q + K E+E L
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173
Query: 166 SQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAER 225
LEEE H+ + + +A + AE+ ++ + LEK K + ELA E
Sbjct: 1174 KTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEV 1233
Query: 226 KRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLK 271
K LQ + E + + + + ++L+ K N E L +++ L+
Sbjct: 1234 KVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ 1279
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/222 (20%), Positives = 101/222 (45%), Gaps = 20/222 (9%)
Query: 88 KQCKNMQERMLS---QLAAAESRHRKVILDLEEERQRHAQDTAEGD---DVTYMLEKERE 141
K+ K+M+ M+ +LAAAE R+ + +E A + +G + LE
Sbjct: 1673 KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 142 RLTQQLEFEKSQVKKFEKEQKKLSSQLEE-------ERS---RHKQLSSMLVLECKKATN 191
+L ++LE E+ + KK + Q+++ ERS +++ L + K+
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKV 1792
Query: 192 KAAE-EGQKAGELSLKLEKEKSRVSKLEEEL---AAERKRGLQTEAQVEKQLSEFDIERE 247
K E EG + + ++++++LEE+L ER+ + + EK+L + ++ +
Sbjct: 1793 KLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVD 1852
Query: 248 QLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQ 289
R + +++ ++ LK+ +++ E Q ++ + +
Sbjct: 1853 DERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRR 1894
Score = 40.4 bits (93), Expect = 0.005
Identities = 57/315 (18%), Positives = 128/315 (40%), Gaps = 44/315 (13%)
Query: 21 ELEARDLVIEALK-AQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNP 79
E EAR+ +AL A+ + +E++ ++ D + K+ + G+
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKD-DVGKSVHELEKS 1526
Query: 80 LSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKE 139
L+ +++ K E + +L A E ++ ++L+ + + +D D+ + +K+
Sbjct: 1527 KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQ 1586
Query: 140 RERLTQQLEFEKSQV-----------KKFEKEQKKLSSQLEE-ERSRHKQLSSMLVLECK 187
R +++E E KK E + K L + ++ ++R + + + L+ +
Sbjct: 1587 LVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQ 1646
Query: 188 KA--------TNKAAEEG-QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ 238
T + EE +A E KL+ ++ + +L+EELAA + Q + + ++
Sbjct: 1647 MKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDEL 1706
Query: 239 LSE-----------------FDIEREQLRAKLNREENRTKTLKEEME----SLKKIVKDL 277
E + QL +L E+ T+ + + ++ + +I DL
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 278 EASHQHSSPNEQLKK 292
H+ NE ++
Sbjct: 1767 NLERSHAQKNENARQ 1781
Score = 37.7 bits (86), Expect = 0.033
Identities = 40/202 (19%), Positives = 88/202 (43%), Gaps = 21/202 (10%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+EA AQ + EE+ I+D L + + + E+ N + + + +
Sbjct: 1727 LEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNE-NARQQLER 1785
Query: 89 QCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLE 148
Q K ++ ++ +S+++ I LE + + LE++ + T++ +
Sbjct: 1786 QNKELKVKLQEMEGTVKSKYKASITALEAKIAQ--------------LEEQLDNETKERQ 1831
Query: 149 FEKSQVKKFEKEQKKLSSQLEEERSRHKQL------SSMLVLECKKATNKAAEEGQKAGE 202
QV++ EK+ K + Q+++ER +Q +S + + K+ +A EE Q+A
Sbjct: 1832 AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Query: 203 LSLKLEKEKSRVSKLEEELAAE 224
KL++E ++ + + E
Sbjct: 1892 SRRKLQRELEDATETADAMNRE 1913
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 68.6 bits (166), Expect = 2e-11
Identities = 48/216 (22%), Positives = 103/216 (47%), Gaps = 8/216 (3%)
Query: 112 ILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEE 171
I+DL+ E+ QD E +D E + L +++ E + ++K + +++++ L+E
Sbjct: 342 IVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDEL 401
Query: 172 RSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQT 231
+ QL L K+ K AEE Q L +L ++S++S EEELA R +
Sbjct: 402 DEQKAQLEEQL----KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR----EE 453
Query: 232 EAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLK 291
++++++ +E + E +A+L + + ++E+ S++ + +++ H+S
Sbjct: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCS 513
Query: 292 KPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNI 327
P ++ AT+ L + +T + SN+
Sbjct: 514 SPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNL 549
Score = 31.2 bits (69), Expect = 3.1
Identities = 56/249 (22%), Positives = 102/249 (40%), Gaps = 27/249 (10%)
Query: 18 LEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCT 77
+E +L+ ++ I+ ++ +D E + N+ L A ++ + L ++ D +K +
Sbjct: 352 VEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK-LQAQKQQVQELLDELDEQKAQLEE 410
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAA-------AESRHRKVILDLEEERQRHAQDTAEGD 130
LK V K+C + +++S L A S + + + EE R Q+TAE +
Sbjct: 411 Q----LKEVRKKCAE-EAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELE 465
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFE------KEQKKLSSQLEEERSRHKQLSSMLVL 184
+ + + E L Q L+ + ++ + K+ + +SQL S H L +
Sbjct: 466 ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATD 525
Query: 185 ECKKATNKAAE-------EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEK 237
C +T+ + EGQ E S + +E S E + T A EK
Sbjct: 526 YCSLSTSSSETANLNEHVEGQSNLE-SEPIHQESPARSSPELLPSGVTDENEVTTAVTEK 584
Query: 238 QLSEFDIER 246
SE D R
Sbjct: 585 VCSELDNNR 593
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 66.2 bits (160), Expect = 9e-11
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 46/297 (15%)
Query: 21 ELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPL 80
E++ ++ +IE L + IEE + D L + L+E+ + Q + L
Sbjct: 323 EIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378
Query: 81 SILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER 140
+ K+ ++ +E + QL +EE ++R+ +D+ D+ +E+E
Sbjct: 379 ELTNSKQKERQSSEE--IKQLMGT----------VEELQKRNHKDSQFETDIVQRMEQET 426
Query: 141 ERLTQQLEFEKSQVKKFEKEQKKLS------SQLEEERSRHK-QLSSMLVLECKKATNKA 193
+R +QL E ++ + Q K +Q+EE ++RHK ++ + L + +N
Sbjct: 427 QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL----RSYSNIT 482
Query: 194 AEEGQ------KAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIERE 247
E Q EL++KL+ S+ KL+EEL + + Q+E + E RE
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 248 QLR----------AKLNREENRTKT---LKEEMESLKKIVKDLEASHQHSSPNEQLK 291
Q++ +KLN T LK E+ S + K+LE H+ N ++K
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Score = 51.6 bits (122), Expect = 2e-06
Identities = 73/325 (22%), Positives = 138/325 (42%), Gaps = 30/325 (9%)
Query: 3 LEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDP---LMALQR 59
L+K + LL+ L ++ R + LK + + +YNI ++ +Q
Sbjct: 3082 LQKADRRSLLSEIQALHAQMNGRKIT---LKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
Query: 60 DFETLK-------EKNDGEKQPVCT--NPLSILKVVMKQCKNMQERMLSQLAAAESRHRK 110
+ ++K E+ EK V + L+ K+ ++ Q + L +L A +
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3198
Query: 111 VILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK--KFEKE-QKKLSSQ 167
++ A + + ++ + LEKE+ +L + E +K +++ KF E QK+ + Q
Sbjct: 3199 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3258
Query: 168 LEEERSRHKQL--SSMLVLECKKATNKA--AEEGQKAGELSLKLEKEKSRVSKLEEELAA 223
L + KQL S +E ++ A +EE + EL + LE EK R+ ++ L
Sbjct: 3259 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3318
Query: 224 ERKRGLQTEA-----QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLE 278
ER+ Q ++ Q L D+ +E L+ +L + +R L E E K + L+
Sbjct: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKE-LQKQLEEKHSRIVELLNETEKYK--LDSLQ 3375
Query: 279 ASHQHSSPNEQLKKPVTVSKGTATE 303
Q + +K + + TE
Sbjct: 3376 TRQQMEKDRQVHRKTLQTEQEANTE 3400
Score = 49.3 bits (116), Expect = 1e-05
Identities = 57/258 (22%), Positives = 117/258 (45%), Gaps = 24/258 (9%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
Q +++ +++ + + ++ EE + + ++ EKE+ L Q+++ + +
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 154 VKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK------KATNKAAEEGQKAGELSLKL 207
+ EK+ K+ + L+E+ ++ + +S+L E K K ++E + S+K
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK- 810
Query: 208 EKEKSRVSKLEEELAAE-----RKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKT 262
K K V + E E+ E +++ +Q ++EKQ + F A+ N E N +
Sbjct: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSF------AEKNFEVN-YQE 863
Query: 263 LKEEMESLKKIVKDLEASH-----QHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESF 317
L+EE L K+ DLE S ++ S + L + + + + T M SVF + ++F
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTF 923
Query: 318 PAERTHGSNIAKMTNTGL 335
AE + + T L
Sbjct: 924 VAETLEMGEVVEKDTTEL 941
Score = 46.2 bits (108), Expect = 9e-05
Identities = 57/264 (21%), Positives = 114/264 (43%), Gaps = 33/264 (12%)
Query: 62 ETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQR 121
E+ ++K + + C L ++ + + R QLA S+ VI +E+
Sbjct: 1881 ESFRQKQEATESLKCQEEL-------RERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933
Query: 122 HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSM 181
+ E D+ LE+E + +L+ +++ ++ ++E++ LS Q E ++ +
Sbjct: 1934 FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
Query: 182 LVLECKKATNKAAE---EGQKAGE--------LSLKLEKEKSRVSKLEEELAAE----RK 226
L+ E +K + E + +K + L + +E++ SR +LE+E E R+
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ 2053
Query: 227 RGLQTEAQVEKQ---LSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQH 283
+ E Q+EK L E I+RE R +E +++E K+V + +H
Sbjct: 2054 QNQALEKQLEKMRKFLDEQAIDREHERDVFQQE-------IQKLEQQLKVVPRFQPISEH 2106
Query: 284 SSPN-EQLKKPVTVSKGTATEPLM 306
+ EQL + +E L+
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLL 2130
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/147 (28%), Positives = 72/147 (48%), Gaps = 23/147 (15%)
Query: 136 LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAE 195
L+++ E L ++L F + Q+++ + + S+L E HK LS++ E KA +A
Sbjct: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA---HKSLSTV---EDLKAEIVSAS 579
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
E +K EL LK E E + K++ E+ + K A +++ + E E+LR +L
Sbjct: 580 ESRK--ELELKHEAEVTNY-KIKLEMLEKEKN-----AVLDRMAESQEAELERLRTQL-- 629
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQ 282
L E L K+ +DLE H+
Sbjct: 630 -------LFSHEEELSKLKEDLEIEHR 649
Score = 43.9 bits (102), Expect = 5e-04
Identities = 63/282 (22%), Positives = 114/282 (40%), Gaps = 63/282 (22%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMK---QCKNMQERMLSQLAAAESRHRKVI- 112
L R E +K + +Q + ++K ++ Q + +++ + Q+ A E + +
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
Query: 113 --LDLEEERQRHAQDTAEGDD-VTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLE 169
++LE+E+ D + + + LEK R+ L +Q + + F++E +KL QL+
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 170 EERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL--------------KLEKEKSRVS 215
R + +S E ++ N E+ K EL L ++EK + RV
Sbjct: 2096 VV-PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 216 KLEEEL-----------------AAERKRGLQTEAQV-----------------EKQLSE 241
+LE+ L A E K L E Q+ E+QL +
Sbjct: 2155 ELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQ 2214
Query: 242 FDIERE-------QLRAKLNREENRTKTLKEEMESLKKIVKD 276
F E E QL +L ++ + T +E+E K+ KD
Sbjct: 2215 FREELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD 2256
Score = 40.4 bits (93), Expect = 0.005
Identities = 44/219 (20%), Positives = 97/219 (44%), Gaps = 24/219 (10%)
Query: 95 ERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV 154
E M S+LA + ++ +LEE R + + + K+R+ + QL Q
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 155 KKFEKEQKK----LSSQLEEERSRHKQLSSMLVLECKKATNKAA---------------- 194
++ + E + L+ Q ++ + + +QL + L ++ AA
Sbjct: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
Query: 195 -EEGQKAGELSLKLEKEKSRVSKLEEELAA-ERKRGLQTEAQVEKQLSEFDIEREQLRAK 252
E+ + K E ++S L+E++ E ++ + E ++++ E + E+L K
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 253 LNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLK 291
+ EE +T LK+++ + K++ +L+ Q N+++K
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQ--EQIVQKNQEIK 374
Score = 38.5 bits (88), Expect = 0.019
Identities = 60/274 (21%), Positives = 111/274 (40%), Gaps = 28/274 (10%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLS-ILKVVMKQCKNMQERMLSQLAAAESRHRKVIL--- 113
+R+ + +DG Q P +LK + KQ + R++ L E +
Sbjct: 3319 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQ 3378
Query: 114 DLEEERQRHAQD-------TAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSS 166
+E++RQ H + EG + L+ + E L +QLE ++ QV K + E ++L
Sbjct: 3379 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3438
Query: 167 QLEE------ERSRHKQLSSMLVLECKKATN-KAAEEGQKAGELSLKLEKE--KSRVSKL 217
++E ER ++ +L + T + + L K+E E +S +KL
Sbjct: 3439 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3498
Query: 218 EEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEE-----MESLKK 272
E G E ++ +Q + + Q+ + E + +T +E E++ +
Sbjct: 3499 IEMNGG--GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3556
Query: 273 IVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLM 306
I+ L+ L P T S G+ TE L+
Sbjct: 3557 IILQLQKLTGQQGEEPSLVSPST-SCGSLTERLL 3589
Score = 35.0 bits (79), Expect = 0.21
Identities = 26/116 (22%), Positives = 57/116 (49%), Gaps = 3/116 (2%)
Query: 158 EKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKL 217
E++ + + +L + H+Q + +L + + E+ ++ E +L ++ ++ S +
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSI 1643
Query: 218 EEE-LAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKK 272
+ E L +ER+R L E + KQLS RE+L +L +T+ E +++
Sbjct: 1644 DNENLVSERERVLLEELEALKQLSL--AGREKLCCELRNSSTQTQNGNENQGEVEE 1697
Score = 34.7 bits (78), Expect = 0.28
Identities = 48/213 (22%), Positives = 90/213 (42%), Gaps = 26/213 (12%)
Query: 135 MLEKERERLTQQLEFEKSQVKKFEKEQK---------KLSSQLEEERSRHKQLSSMLVLE 185
+LEKE++ L Q E ++ K+ EKE+K K +++L + + L
Sbjct: 2636 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2695
Query: 186 CKKATNKA--AEEGQKAGELSLKLEKEKSRVSKLEEELA------AERKRGL-------Q 230
+ KA A +KA +L +L +++ ++ L+++L+ AE K L +
Sbjct: 2696 AESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE 2755
Query: 231 TEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
TE Q K+ F+ +L + + + T + ++ + +VK+ A Q + +E
Sbjct: 2756 TEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN--AGIQINLQSECS 2813
Query: 291 KKPVTVSKGTATEPLMLMSVFCQTESFPAERTH 323
+ VT TE + M E E H
Sbjct: 2814 SEEVTEIISQFTEKIEKMQELHAAEILDMESRH 2846
Score = 33.1 bits (74), Expect = 0.81
Identities = 36/139 (25%), Positives = 64/139 (46%), Gaps = 16/139 (11%)
Query: 138 KERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+E+ L + LE +Q++ +Q+ + EEE +QL+ ++ +K + A G
Sbjct: 2318 EEKNELIRDLE---TQIECLMSDQECVKRNREEEI---EQLNEVI----EKLQQELANIG 2367
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRA---KLN 254
QK + L +E + + + AE+ L E QVE E + L+ K+N
Sbjct: 2368 QKTSMNAHSLSEEADSLKHQLDVVIAEK---LALEQQVETANEEMTFMKNVLKETNFKMN 2424
Query: 255 REENRTKTLKEEMESLKKI 273
+ +LK E ES++KI
Sbjct: 2425 QLTQELFSLKRERESVEKI 2443
Score = 32.3 bits (72), Expect = 1.4
Identities = 58/278 (20%), Positives = 121/278 (43%), Gaps = 25/278 (8%)
Query: 18 LEGELEARDLVIEALKAQ--HRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV 75
LE E++ L E L+ Q ++ ++E++ + + + L+ + +TL++
Sbjct: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI--LKDEKKTLEDMLKIHTPVS 798
Query: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRK---VILDLEEERQRHAQDTAEGD-D 131
L L + + K+ ++ E+ K + L+ E E+QR+ AE + +
Sbjct: 799 QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858
Query: 132 VTYM-LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
V Y L++E L + + + K E E K L EE H Q + ++ K +
Sbjct: 859 VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL--HLQRINPTTVKMKSSV 916
Query: 191 ----NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIER 246
E + GE+ +EK+ ++L E+L ++ L+ + ++LS+ +
Sbjct: 917 FDEDKTFVAETLEMGEV---VEKD---TTELMEKLEVTKREKLE----LSQRLSDLSEQL 966
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHS 284
+Q +++ K+LK+E E + ++LE H+
Sbjct: 967 KQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
Score = 29.6 bits (65), Expect = 8.9
Identities = 35/167 (20%), Positives = 73/167 (43%), Gaps = 25/167 (14%)
Query: 138 KERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
K+ + + +Q +FE ++K K ++ Q E L S + LE + K ++
Sbjct: 2520 KQIKDMQEQGQFETEMLQK-----KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2574
Query: 198 QKAGELSLKLEKEKSRVSKLEE--------ELAAERKRGLQTEAQVEKQLSEFDIEREQL 249
Q ++ E E++ + L + +++A R + E+QV + + +E+EQ+
Sbjct: 2575 Q-----TISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQV 2629
Query: 250 RAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTV 296
E K + E+ + L ++ K LE + + E+ + P V
Sbjct: 2630 -------EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2669
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 66.2 bits (160), Expect = 9e-11
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 46/297 (15%)
Query: 21 ELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPL 80
E++ ++ +IE L + IEE + D L + L+E+ + Q + L
Sbjct: 323 EIQEKETIIEELNTK----IIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKL 378
Query: 81 SILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKER 140
+ K+ ++ +E + QL +EE ++R+ +D+ D+ +E+E
Sbjct: 379 ELTNSKQKERQSSEE--IKQLMGT----------VEELQKRNHKDSQFETDIVQRMEQET 426
Query: 141 ERLTQQLEFEKSQVKKFEKEQKKLS------SQLEEERSRHK-QLSSMLVLECKKATNKA 193
+R +QL E ++ + Q K +Q+EE ++RHK ++ + L + +N
Sbjct: 427 QRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENAL----RSYSNIT 482
Query: 194 AEEGQ------KAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIERE 247
E Q EL++KL+ S+ KL+EEL + + Q+E + E RE
Sbjct: 483 VNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSRE 542
Query: 248 QLR----------AKLNREENRTKT---LKEEMESLKKIVKDLEASHQHSSPNEQLK 291
Q++ +KLN T LK E+ S + K+LE H+ N ++K
Sbjct: 543 QIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIK 599
Score = 51.6 bits (122), Expect = 2e-06
Identities = 73/325 (22%), Positives = 138/325 (42%), Gaps = 30/325 (9%)
Query: 3 LEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDP---LMALQR 59
L+K + LL+ L ++ R + LK + + +YNI ++ +Q
Sbjct: 3074 LQKADRRSLLSEIQALHAQMNGRKIT---LKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130
Query: 60 DFETLK-------EKNDGEKQPVCT--NPLSILKVVMKQCKNMQERMLSQLAAAESRHRK 110
+ ++K E+ EK V + L+ K+ ++ Q + L +L A +
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKD 3190
Query: 111 VILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVK--KFEKE-QKKLSSQ 167
++ A + + ++ + LEKE+ +L + E +K +++ KF E QK+ + Q
Sbjct: 3191 KTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQ 3250
Query: 168 LEEERSRHKQL--SSMLVLECKKATNKA--AEEGQKAGELSLKLEKEKSRVSKLEEELAA 223
L + KQL S +E ++ A +EE + EL + LE EK R+ ++ L
Sbjct: 3251 LNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDR 3310
Query: 224 ERKRGLQTEA-----QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLE 278
ER+ Q ++ Q L D+ +E L+ +L + +R L E E K + L+
Sbjct: 3311 ERELHAQLQSSDGTGQSRPPLPSEDLLKE-LQKQLEEKHSRIVELLNETEKYK--LDSLQ 3367
Query: 279 ASHQHSSPNEQLKKPVTVSKGTATE 303
Q + +K + + TE
Sbjct: 3368 TRQQMEKDRQVHRKTLQTEQEANTE 3392
Score = 49.3 bits (116), Expect = 1e-05
Identities = 57/258 (22%), Positives = 117/258 (45%), Gaps = 24/258 (9%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
Q +++ +++ + + ++ EE + + ++ EKE+ L Q+++ + +
Sbjct: 692 QNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLK 751
Query: 154 VKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK------KATNKAAEEGQKAGELSLKL 207
+ EK+ K+ + L+E+ ++ + +S+L E K K ++E + S+K
Sbjct: 752 TELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEERLIFLDSIK- 810
Query: 208 EKEKSRVSKLEEELAAE-----RKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKT 262
K K V + E E+ E +++ +Q ++EKQ + F A+ N E N +
Sbjct: 811 SKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSF------AEKNFEVN-YQE 863
Query: 263 LKEEMESLKKIVKDLEASH-----QHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESF 317
L+EE L K+ DLE S ++ S + L + + + + T M SVF + ++F
Sbjct: 864 LQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTF 923
Query: 318 PAERTHGSNIAKMTNTGL 335
AE + + T L
Sbjct: 924 VAETLEMGEVVEKDTTEL 941
Score = 47.0 bits (110), Expect = 5e-05
Identities = 63/274 (22%), Positives = 114/274 (41%), Gaps = 55/274 (20%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMK---QCKNMQERMLSQLAAAESRHRKVI- 112
L R E +K + +Q + ++K ++ Q + +++ + Q+ A E + +
Sbjct: 1976 LSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVS 2035
Query: 113 --LDLEEERQRHAQDTAEGDD-VTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLE 169
++LE+E+ D + + + LEK R+ L +Q + + F++E +KL QL+
Sbjct: 2036 RFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLK 2095
Query: 170 EERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL--------------KLEKEKSRVS 215
R + +S E ++ N E+ K EL L ++EK + RV
Sbjct: 2096 VV-PRFQPISEHQTREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVR 2154
Query: 216 KLEEEL---------AAERKRGLQTEAQV-----------------EKQLSEFDIERE-- 247
+LE+ L A E K L E Q+ E+QL +F E E
Sbjct: 2155 ELEQALLVEDRKHFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENK 2214
Query: 248 -----QLRAKLNREENRTKTLKEEMESLKKIVKD 276
QL +L ++ + T +E+E K+ KD
Sbjct: 2215 NEEVQQLHMQLEIQKKESTTRLQELEQENKLFKD 2248
Score = 46.2 bits (108), Expect = 9e-05
Identities = 57/264 (21%), Positives = 114/264 (43%), Gaps = 33/264 (12%)
Query: 62 ETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQR 121
E+ ++K + + C L ++ + + R QLA S+ VI +E+
Sbjct: 1881 ESFRQKQEATESLKCQEEL-------RERLHEESRAREQLAVELSKAEGVIDGYADEKTL 1933
Query: 122 HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSM 181
+ E D+ LE+E + +L+ +++ ++ ++E++ LS Q E ++ +
Sbjct: 1934 FERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQ 1993
Query: 182 LVLECKKATNKAAE---EGQKAGE--------LSLKLEKEKSRVSKLEEELAAE----RK 226
L+ E +K + E + +K + L + +E++ SR +LE+E E R+
Sbjct: 1994 LLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQ 2053
Query: 227 RGLQTEAQVEKQ---LSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQH 283
+ E Q+EK L E I+RE R +E +++E K+V + +H
Sbjct: 2054 QNQALEKQLEKMRKFLDEQAIDREHERDVFQQE-------IQKLEQQLKVVPRFQPISEH 2106
Query: 284 SSPN-EQLKKPVTVSKGTATEPLM 306
+ EQL + +E L+
Sbjct: 2107 QTREVEQLANHLKEKTDKCSELLL 2130
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/147 (28%), Positives = 72/147 (48%), Gaps = 23/147 (15%)
Query: 136 LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAE 195
L+++ E L ++L F + Q+++ + + S+L E HK LS++ E KA +A
Sbjct: 526 LQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEA---HKSLSTV---EDLKAEIVSAS 579
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
E +K EL LK E E + K++ E+ + K A +++ + E E+LR +L
Sbjct: 580 ESRK--ELELKHEAEVTNY-KIKLEMLEKEKN-----AVLDRMAESQEAELERLRTQL-- 629
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQ 282
L E L K+ +DLE H+
Sbjct: 630 -------LFSHEEELSKLKEDLEIEHR 649
Score = 40.4 bits (93), Expect = 0.005
Identities = 44/219 (20%), Positives = 97/219 (44%), Gaps = 24/219 (10%)
Query: 95 ERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV 154
E M S+LA + ++ +LEE R + + + K+R+ + QL Q
Sbjct: 158 EMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQA 217
Query: 155 KKFEKEQKK----LSSQLEEERSRHKQLSSMLVLECKKATNKAA---------------- 194
++ + E + L+ Q ++ + + +QL + L ++ AA
Sbjct: 218 RREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQL 277
Query: 195 -EEGQKAGELSLKLEKEKSRVSKLEEELAA-ERKRGLQTEAQVEKQLSEFDIEREQLRAK 252
E+ + K E ++S L+E++ E ++ + E ++++ E + E+L K
Sbjct: 278 EEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTK 337
Query: 253 LNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLK 291
+ EE +T LK+++ + K++ +L+ Q N+++K
Sbjct: 338 IIEEEKKTLELKDKLTTADKLLGELQ--EQIVQKNQEIK 374
Score = 38.5 bits (88), Expect = 0.019
Identities = 60/274 (21%), Positives = 111/274 (40%), Gaps = 28/274 (10%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLS-ILKVVMKQCKNMQERMLSQLAAAESRHRKVIL--- 113
+R+ + +DG Q P +LK + KQ + R++ L E +
Sbjct: 3311 ERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLDSLQTRQ 3370
Query: 114 DLEEERQRHAQD-------TAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSS 166
+E++RQ H + EG + L+ + E L +QLE ++ QV K + E ++L
Sbjct: 3371 QMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQG 3430
Query: 167 QLEE------ERSRHKQLSSMLVLECKKATN-KAAEEGQKAGELSLKLEKE--KSRVSKL 217
++E ER ++ +L + T + + L K+E E +S +KL
Sbjct: 3431 IMQEFQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKL 3490
Query: 218 EEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEE-----MESLKK 272
E G E ++ +Q + + Q+ + E + +T +E E++ +
Sbjct: 3491 IEMNGG--GTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDE 3548
Query: 273 IVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLM 306
I+ L+ L P T S G+ TE L+
Sbjct: 3549 IILQLQKLTGQQGEEPSLVSPST-SCGSLTERLL 3581
Score = 35.0 bits (79), Expect = 0.21
Identities = 26/116 (22%), Positives = 57/116 (49%), Gaps = 3/116 (2%)
Query: 158 EKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKL 217
E++ + + +L + H+Q + +L + + E+ ++ E +L ++ ++ S +
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSI 1643
Query: 218 EEE-LAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKK 272
+ E L +ER+R L E + KQLS RE+L +L +T+ E +++
Sbjct: 1644 DNENLVSERERVLLEELEALKQLSL--AGREKLCCELRNSSTQTQNGNENQGEVEE 1697
Score = 34.7 bits (78), Expect = 0.28
Identities = 48/213 (22%), Positives = 90/213 (42%), Gaps = 26/213 (12%)
Query: 135 MLEKERERLTQQLEFEKSQVKKFEKEQK---------KLSSQLEEERSRHKQLSSMLVLE 185
+LEKE++ L Q E ++ K+ EKE+K K +++L + + L
Sbjct: 2628 VLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALR 2687
Query: 186 CKKATNKA--AEEGQKAGELSLKLEKEKSRVSKLEEELA------AERKRGL-------Q 230
+ KA A +KA +L +L +++ ++ L+++L+ AE K L +
Sbjct: 2688 AESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDE 2747
Query: 231 TEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
TE Q K+ F+ +L + + + T + ++ + +VK+ A Q + +E
Sbjct: 2748 TEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKN--AGIQINLQSECS 2805
Query: 291 KKPVTVSKGTATEPLMLMSVFCQTESFPAERTH 323
+ VT TE + M E E H
Sbjct: 2806 SEEVTEIISQFTEKIEKMQELHAAEILDMESRH 2838
Score = 33.9 bits (76), Expect = 0.47
Identities = 69/320 (21%), Positives = 136/320 (42%), Gaps = 54/320 (16%)
Query: 4 EKLSK-PELLTLFSILEGELEARDLVIEALKAQHRDT----FIEER--YGKYNISDPLMA 56
EK K ELL L+ +++ R+ IE L+ + R+ +E+R +G + P ++
Sbjct: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVE-AKPELS 2178
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLS---QLAAAESRHRKVIL 113
L+ + ++ D +++ + TN L+ ++ +N E + QL + +
Sbjct: 2179 LEVQLQAERDAIDRKEKEI-TNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQ 2237
Query: 114 DLEEERQRHAQDTA-------EGDDVT----YMLEKERERLTQQLEFE----KSQVKKFE 158
+LE+E + D E D ++ ++L + ++ Q+ E E QV K +
Sbjct: 2238 ELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQ 2297
Query: 159 KEQKKLSSQ--LEEERSRHKQLSSMLVL-----ECKKATNKAAEEGQKAGELSLKLEKEK 211
++ K + +EE+ + L + + EC K + EE ++ E+ KL++E
Sbjct: 2298 QQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNRE--EEIEQLNEVIEKLQQEL 2355
Query: 212 SRVSK---------------LEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRA---KL 253
+ + + L+ +L L E QVE E + L+ K+
Sbjct: 2356 ANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKM 2415
Query: 254 NREENRTKTLKEEMESLKKI 273
N+ +LK E ES++KI
Sbjct: 2416 NQLTQELFSLKRERESVEKI 2435
Score = 32.3 bits (72), Expect = 1.4
Identities = 58/278 (20%), Positives = 121/278 (43%), Gaps = 25/278 (8%)
Query: 18 LEGELEARDLVIEALKAQ--HRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV 75
LE E++ L E L+ Q ++ ++E++ + + + L+ + +TL++
Sbjct: 741 LEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSI--LKDEKKTLEDMLKIHTPVS 798
Query: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRK---VILDLEEERQRHAQDTAEGD-D 131
L L + + K+ ++ E+ K + L+ E E+QR+ AE + +
Sbjct: 799 QEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFE 858
Query: 132 VTYM-LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
V Y L++E L + + + K E E K L EE H Q + ++ K +
Sbjct: 859 VNYQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEEL--HLQRINPTTVKMKSSV 916
Query: 191 ----NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIER 246
E + GE+ +EK+ ++L E+L ++ L+ + ++LS+ +
Sbjct: 917 FDEDKTFVAETLEMGEV---VEKD---TTELMEKLEVTKREKLE----LSQRLSDLSEQL 966
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHS 284
+Q +++ K+LK+E E + ++LE H+
Sbjct: 967 KQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHN 1004
Score = 29.6 bits (65), Expect = 8.9
Identities = 35/167 (20%), Positives = 73/167 (43%), Gaps = 25/167 (14%)
Query: 138 KERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
K+ + + +Q +FE ++K K ++ Q E L S + LE + K ++
Sbjct: 2512 KQIKDMQEQGQFETEMLQK-----KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDN 2566
Query: 198 QKAGELSLKLEKEKSRVSKLEE--------ELAAERKRGLQTEAQVEKQLSEFDIEREQL 249
Q ++ E E++ + L + +++A R + E+QV + + +E+EQ+
Sbjct: 2567 Q-----TISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKEQV 2621
Query: 250 RAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTV 296
E K + E+ + L ++ K LE + + E+ + P V
Sbjct: 2622 -------EIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDV 2661
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 65.1 bits (157), Expect = 2e-10
Identities = 109/519 (21%), Positives = 214/519 (41%), Gaps = 68/519 (13%)
Query: 17 ILEGELEARDLV-IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV 75
+L + E +L+ + A+ T + R K + ++ L L++ L E+N G +
Sbjct: 1399 LLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA------EG 129
L+V + Q + E+ + +LAA + + +++ E Q A++ EG
Sbjct: 1459 NLGR-QFLEVELDQAR---EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEG 1514
Query: 130 DDVTYMLEK-----ERERLTQQLE----FEKSQVKKFEKEQKKLSSQLEEERSRHKQLSS 180
V + E+ ER++LT Q+E F++ Q K+ E+ KKL+ + + + ++L +
Sbjct: 1515 AKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKA 1574
Query: 181 M-------------LVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKR 227
+ L + + + +++ Q A L++EK K+ +++ E +
Sbjct: 1575 VQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQ-NQELQE 1633
Query: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPN 287
L++ Q++K+ E E E+L +L + +TK ++ L V+ LEA H+ +
Sbjct: 1634 QLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHA--D 1691
Query: 288 EQL----KKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNI---AKMTNTGLPGPAT 340
+QL K V + EP + +S G+ + +K+ T G +
Sbjct: 1692 QQLRDLGKFQVATDALKSREPQAKPQLDLSIDSLDLSCEEGTPLSITSKLPRTQPDGTSV 1751
Query: 341 PAYSYAKTNGHCDPEIQTTRELTAGNNVENQVPPREKSVALAQEKPVENGG--------- 391
P + + P++++ L P E S+ + +++G
Sbjct: 1752 PGEPASPISQRLPPKVESLESLYFTPIPARSQAPLESSLDSLGDVFLDSGRKTRSARRRT 1811
Query: 392 ---CPVGIETPVPMPSPLSSSGSSLS----PSSTASSSLTSSPCSSPVLTKRLLGSSA-- 442
+ + + + P S++ S S P+S AS TSS S L G+SA
Sbjct: 1812 TQIINITMTKKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALL 1871
Query: 443 SSPGYQSS-------YQVGINQRFHAARHKFQSQADQDQ 474
S PGY+ + Q G++ R+ F QD+
Sbjct: 1872 SLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDE 1910
Score = 57.4 bits (137), Expect = 4e-08
Identities = 59/239 (24%), Positives = 107/239 (44%), Gaps = 12/239 (5%)
Query: 71 EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGD 130
EKQ L + + ++ E++ S L E + ++V E RQ HAQ A
Sbjct: 530 EKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAA 589
Query: 131 DVTYMLEKERERLTQQLE-FEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKA 189
+ +ER+ +QLE EK + K E Q++L Q+ E Q S K
Sbjct: 590 EEREASLRERDAALKQLEALEKEKAAKLEILQQQL--QVANEARDSAQTSVTQAQREKAE 647
Query: 190 TNKAAEEGQKAGELSLKLEKE-KSRVSKLEEELAAERKRGLQTE--AQVEKQLSE-FDIE 245
++ EE Q E + + + E +++V++LE +L +E+++ + E AQ + QL E
Sbjct: 648 LSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 246 REQLRAKLNREENRTKTLKEEMESLKKIVKDLEAS-----HQHSSPNEQLKKPVTVSKG 299
+E L+ E + + +E ++ + +L+A QH ++L++ KG
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKG 766
Score = 50.1 bits (118), Expect = 6e-06
Identities = 58/218 (26%), Positives = 103/218 (47%), Gaps = 31/218 (14%)
Query: 91 KNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE 150
K++ +++ ++ AAAE RHR+ +LE+ +Q A G +L +RE E
Sbjct: 1364 KHLCQQLQAEQAAAEKRHRE---ELEQSKQ------AAGGLRAELLRAQREL------GE 1408
Query: 151 KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELS------ 204
+++ EQ++ + QL E++ + + SML KKA AEE + GE +
Sbjct: 1409 LIPLRQKVAEQERTAQQLRAEKASYAEQLSML----KKAHGLLAEENRGLGERANLGRQF 1464
Query: 205 LKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE----NRT 260
L++E +++R K +ELAA R A+V+++ E E + AK +
Sbjct: 1465 LEVELDQAR-EKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEER 1523
Query: 261 KTLKEEMESLKKIVKDLEA-SHQHSSPNEQLKKPVTVS 297
+ +EE + L V+ LE + + E+L K + S
Sbjct: 1524 QRFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADS 1561
Score = 48.1 bits (113), Expect = 2e-05
Identities = 58/216 (26%), Positives = 97/216 (44%), Gaps = 18/216 (8%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERER-LTQQLEFEKS 152
QE SQ A A ++ + + A+D + E ER+ L LE E S
Sbjct: 1176 QELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVS 1235
Query: 153 ----QVKKFEKEQKKLSSQLEEERSRHKQLSSML-VLECKKATN--KAAEEGQKAGE--L 203
QV + E E K+L + E + ++L L +L+ + A+N +AAE E
Sbjct: 1236 ILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295
Query: 204 SLKLEKEKSRVSK--LEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTK 261
SL+ E EK RV+ L +EL ++ +R + +++ +F ++EQ + L E T+
Sbjct: 1296 SLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKF-FQKEQALSTLQLEHTSTQ 1354
Query: 262 TLKEEMESLKKIVKDLEASH-----QHSSPNEQLKK 292
L E+ K + + L+A +H EQ K+
Sbjct: 1355 ALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQ 1390
Score = 47.0 bits (110), Expect = 5e-05
Identities = 55/257 (21%), Positives = 115/257 (44%), Gaps = 21/257 (8%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+ L +H E + + L A +D + L+EKN+ + LS L+ +
Sbjct: 341 LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE-----ILQGKLSQLEEHLS 395
Query: 89 QCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDV---TYMLEKERERLTQ 145
Q ++ + ++ +L LE +Q A A + MLE ER +
Sbjct: 396 QLQDNPPQEKGEVLGD-------VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEA 448
Query: 146 QLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL 205
+L E+ FE+E+++LSS + + +S LS + + A + L+
Sbjct: 449 KLLAERGH---FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTS 505
Query: 206 KLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKE 265
+L + + + ++ELA +++ + +AQ+ + L + + + LR ++ E + +LK+
Sbjct: 506 ELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLR---HQVEQLSSSLKQ 562
Query: 266 EMESLKKIVKDLEASHQ 282
+ + LK++ + EA+ Q
Sbjct: 563 KEQQLKEVAEKQEATRQ 579
Score = 46.6 bits (109), Expect = 7e-05
Identities = 72/341 (21%), Positives = 129/341 (37%), Gaps = 58/341 (17%)
Query: 3 LEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFE 62
LEK +L L L+ EARD ++ R+ K +S + LQ E
Sbjct: 609 LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE--------KAELSRKVEELQACVE 660
Query: 63 TLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQ-----ERMLSQLAAAESRHRKVILDLEE 117
T +++ + V L + K + + +++ QL A + + LEE
Sbjct: 661 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
Query: 118 ERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQ 177
E++R A E L+ E L +Q + E+ ++++ +K L ++L++ H+
Sbjct: 721 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780
Query: 178 LSSML--------------VLECKKATNKAA-----------EEGQKAGELSLKLEKEKS 212
+ +L EC++ + A EE Q +L K
Sbjct: 781 ETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 840
Query: 213 RVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTK----------- 261
K +EL +++ E+ E Q+S E +L A L R + +
Sbjct: 841 ECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLAD 900
Query: 262 ---TLKEEMESLKKIVKDLE------ASHQHSSPNEQLKKP 293
TL+E+M + K V LE Q ++ E +K+P
Sbjct: 901 DLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEP 941
Score = 45.8 bits (107), Expect = 1e-04
Identities = 52/205 (25%), Positives = 96/205 (46%), Gaps = 17/205 (8%)
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
+P S + +++ + R+ QLA S ++ L+L E R+ E D M++
Sbjct: 200 SPASPMGDILQTPQFQMRRLKKQLADERSNRDELELELAENRKL----LTEKDAQIAMMQ 255
Query: 138 KERERLTQQLEFEKSQVKKFE-KEQKKLSSQLEEERSR-HKQLSSMLVLECKKAT--NKA 193
+ +RL L EK E KE ++L + E R H+ L L+ +K+ K
Sbjct: 256 QRIDRLA--LLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKI 313
Query: 194 AEEGQKAGELSLKLEKEKSRVSKLEE---ELAAERKRG----LQTEAQVEKQLSEFDIER 246
+ ++ G+LS KL + S + +L++ EL E + L+ +AQ+EK+LS ++
Sbjct: 314 NQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDK 373
Query: 247 EQLRAKLNREENRTKTLKEEMESLK 271
+ L K + + L+E + L+
Sbjct: 374 KCLEEKNEILQGKLSQLEEHLSQLQ 398
Score = 45.4 bits (106), Expect = 2e-04
Identities = 69/307 (22%), Positives = 129/307 (42%), Gaps = 27/307 (8%)
Query: 21 ELEARDLVIEALKAQHRDT-FIEERYGKYNISDP--LMALQRDFETLKEKNDGEKQPVCT 77
E +R+LV E +A R ++EE+ G+ S L A++R+ E + G +
Sbjct: 931 ETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM-----GNELERLR 985
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEE----ERQRHAQDTAEGDDVT 133
L + ++ + QER +++L R + L LE+ E + Q+ V
Sbjct: 986 AALMESQGQQQEERGQQEREVARLTQERGR-AQADLALEKAARAELEMRLQNALNEQRVE 1044
Query: 134 YM-LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNK 192
+ L++ + E + ++ K + +LEE R KQL L + K+ +
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASG 1104
Query: 193 AAEEGQKAGELSL---KLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ---LSEFDIER 246
+ + + AG KLE ++ VSKLE++ ++++ E +E + +E D
Sbjct: 1105 SGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSAL 1164
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIVKDLEA----SHQHSSPNEQLKKPVTVSKGTAT 302
E L+ +L E + + L +L ++L A HS ++ K V + A
Sbjct: 1165 ETLQGQL---EEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAE 1221
Query: 303 EPLMLMS 309
L+S
Sbjct: 1222 RKNSLIS 1228
Score = 37.7 bits (86), Expect = 0.033
Identities = 50/227 (22%), Positives = 96/227 (42%), Gaps = 30/227 (13%)
Query: 91 KNMQERMLSQLAAAESRHRKVILDL-------EEERQRHAQDTAEGDDVTYMLEKERERL 143
+ + E M +Q AES +++ ++ E+ +Q AQ A + L++E E+
Sbjct: 787 RELAEAMAAQ-HTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKA 845
Query: 144 TQQLEFEKSQVKKFEKEQK-KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGE 202
Q+L+ K +V E + ++S Q E H L+ L Q+ E
Sbjct: 846 RQELQEAKEKVAGIESHSELQISRQQNELAELHANLARAL---------------QQVQE 890
Query: 203 LSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKT 262
++ +K +S L+E++AA K + E V K + + +L + R +R
Sbjct: 891 KEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPE 950
Query: 263 LKEEME-----SLKKIVKDLE-ASHQHSSPNEQLKKPVTVSKGTATE 303
EE + S + ++ +E + Q + E+L+ + S+G E
Sbjct: 951 WLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQE 997
Score = 36.2 bits (82), Expect = 0.095
Identities = 41/201 (20%), Positives = 96/201 (47%), Gaps = 16/201 (7%)
Query: 91 KNMQERMLSQLAAAESRHRKVILDLEEERQRH-AQDTAEGDDVTYMLEKERERLTQQLEF 149
K +++ L ++ S + +LE+ Q H A+ TA+ +T E L ++
Sbjct: 461 KQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT----SELTTLNATIQQ 516
Query: 150 EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEK 209
+ ++ +++ K+ +QL + + +Q S L + ++ ++ ++ Q+ E++ K E
Sbjct: 517 QDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEA 576
Query: 210 EKSRVSKLEEELAAERKRGL--------QTEAQVEKQLSEFDIEREQLR-AKLNREENRT 260
+ ++ A ER+ L Q EA +++ ++ +I ++QL+ A R+ +T
Sbjct: 577 TRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQT 636
Query: 261 KTLKEEME--SLKKIVKDLEA 279
+ + E L + V++L+A
Sbjct: 637 SVTQAQREKAELSRKVEELQA 657
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/262 (23%), Positives = 117/262 (44%), Gaps = 31/262 (11%)
Query: 29 IEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV--CTNPLSIL 83
+ +L +Q +DT EE K N+S L L+ + +L+++ D E + +S L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 84 KVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERL 143
+ + K + S + A E ++ ++E Q++ + A D LEK + RL
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRL 1425
Query: 144 TQQLEF-------EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
Q+L+ ++ V EK+Q+K L EE K +SS E +A +A E+
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEAREK 1481
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
KA L+ LE+ +LE +T ++ ++ + ++ + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELE-----------RTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 257 ENRTKTLKEEMESLKKIVKDLE 278
E + L+ +ME +K +++LE
Sbjct: 1531 EKSKRALETQMEEMKTQLEELE 1552
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 40/275 (14%)
Query: 53 PLMALQRDFETLKEKNDG-----EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAA---- 103
PL+ + R E ++ K D E+Q N L L+ Q + + QL A
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 104 -AESRHRKVIL-----DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-------LEFE 150
AE+ +V L +LEE E +D L+ ER+++ QQ LE E
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 151 KSQVKKFEKEQ-------KKLSSQL---EEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
++ +K + E+ KKL ++ +++ ++ + +L T AEE +KA
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQLSEFDIEREQLRAKLNREE 257
L+ K +S +S+LE L E K + E ++E S+F + L+A++ +
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+ +EE+++ + D + + N LKK
Sbjct: 1083 MQLAKKEEELQAALARLDD-----EIAQKNNALKK 1112
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 34/310 (10%)
Query: 16 SILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEK--- 72
++ E E +A++L K + + +E R K S +++ E LK K +G+
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS------RQELEKLKRKLEGDASDF 1067
Query: 73 -QPVCTNPLSILKVVMKQCKNMQE------RMLSQLAAAESRHRKV------ILDLEEE- 118
+ + I ++ M+ K +E R+ ++A + +K+ I DL+E+
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 119 -RQRHAQDTAEGD--DVTYMLEKERERLTQQLEFEKSQVK---KFEKEQKKLSSQLEEER 172
+R A++ AE D+ LE + L L+ +Q + K E+E L L+EE
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 173 SRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE 232
H+ + + +A + E+ ++ L+K K + K +LA E + Q +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 233 AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+VE + + + + ++L++K + E L +++ L+ V+ + NE K
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-----GMLNEAEGK 1302
Query: 293 PVTVSKGTAT 302
+ ++K A+
Sbjct: 1303 AIKLAKDVAS 1312
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/286 (20%), Positives = 120/286 (41%), Gaps = 41/286 (14%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+ L+AQ +D F E D + A ++ E + + + + L+ + K
Sbjct: 1647 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARK 1704
Query: 89 QCKNMQERMLSQLAAAESRHRKV----------ILDLEEERQRHAQDTAEGDDVTYMLEK 138
Q +E + +LA++ S + I LEEE + + D +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 139 ERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQL---------SSMLVLECK-- 187
+ E+L+ +L E+S +K E +++L Q +E RS+ ++ S++ LE K
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 188 --------------KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEA 233
AT ++ +K E+ L++E E+ K+ E+ + ++G
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVK 1880
Query: 234 QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEA 279
Q+++QL E + E +++ A + + E E++ + V L++
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1926
Score = 46.2 bits (108), Expect = 9e-05
Identities = 58/268 (21%), Positives = 115/268 (42%), Gaps = 39/268 (14%)
Query: 47 KYNISDPLMALQRDFETLKEK-NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAE 105
K + L+ + L+ K +DGE+ N + + +N E + L AE
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK------VHKLQNEVESVTGMLNEAE 1300
Query: 106 SRHRKVILD-------LEEERQRHAQDTAEGDDVTY---MLEKERERLTQQLEFEKSQVK 155
+ K+ D L++ ++ ++T + +V+ LE+ER L QL+ E +
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 156 KFEKEQKKLSSQLEEERSRHKQLSSML--VLECKKATNKAAEE-----GQKAGELSLKLE 208
E+ L+ QL + + + + +S + + E KK K E +KA KLE
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLE 1419
Query: 209 KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI--------------EREQLRAKLN 254
K K+R+ + ++L + Q + +EK+ +FD ER++ A+
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 255 REENRTKTLKEEMESLKKIVKDLEASHQ 282
+E + +L +E + ++LE +++
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNK 1507
Score = 42.7 bits (99), Expect = 0.001
Identities = 57/282 (20%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 21 ELEARDLVIEALK-AQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNP 79
E EAR+ +AL A+ + +E + + L A D + K+ + G+
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKS 1533
Query: 80 LSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEE-----ERQRHAQDTAEGDDVTY 134
L+ M++ K E + +L A E ++ ++++ ER A+D + ++
Sbjct: 1534 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEEKRR 1592
Query: 135 MLEKERERLTQQLEFEKSQ-------VKKFEKEQKKLSSQLEEE-RSRHKQLSSMLVLEC 186
L+++ +LE E+ Q KK E + K L Q + + R + + + L+
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1652
Query: 187 K-KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIE 245
+ K + E+ + + + KE + +K L A+ + + A E+ + D+E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLE 1709
Query: 246 REQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPN 287
+E+L +L + L++E L+ + LE + N
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1751
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/262 (23%), Positives = 117/262 (44%), Gaps = 31/262 (11%)
Query: 29 IEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV--CTNPLSIL 83
+ +L +Q +DT EE K N+S L L+ + +L+++ D E + +S L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 84 KVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERL 143
+ + K + S + A E ++ ++E Q++ + A D LEK + RL
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRL 1432
Query: 144 TQQLEF-------EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
Q+L+ ++ V EK+Q+K L EE K +SS E +A +A E+
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEAREK 1488
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
KA L+ LE+ +LE +T ++ ++ + ++ + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELE-----------RTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 257 ENRTKTLKEEMESLKKIVKDLE 278
E + L+ +ME +K +++LE
Sbjct: 1538 EKSKRALETQMEEMKTQLEELE 1559
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 40/275 (14%)
Query: 53 PLMALQRDFETLKEKNDG-----EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAA---- 103
PL+ + R E ++ K D E+Q N L L+ Q + + QL A
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 104 -AESRHRKVIL-----DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-------LEFE 150
AE+ +V L +LEE E +D L+ ER+++ QQ LE E
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 151 KSQVKKFEKEQ-------KKLSSQL---EEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
++ +K + E+ KKL ++ +++ ++ + +L T AEE +KA
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQLSEFDIEREQLRAKLNREE 257
L+ K +S +S+LE L E K + E ++E S+F + L+A++ +
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+ +EE+++ + D + + N LKK
Sbjct: 1090 MQLAKKEEELQAALARLDD-----EIAQKNNALKK 1119
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 34/310 (10%)
Query: 16 SILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEK--- 72
++ E E +A++L K + + +E R K S +++ E LK K +G+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS------RQELEKLKRKLEGDASDF 1074
Query: 73 -QPVCTNPLSILKVVMKQCKNMQE------RMLSQLAAAESRHRKV------ILDLEEE- 118
+ + I ++ M+ K +E R+ ++A + +K+ I DL+E+
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 119 -RQRHAQDTAEGD--DVTYMLEKERERLTQQLEFEKSQVK---KFEKEQKKLSSQLEEER 172
+R A++ AE D+ LE + L L+ +Q + K E+E L L+EE
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 173 SRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE 232
H+ + + +A + E+ ++ L+K K + K +LA E + Q +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 233 AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+VE + + + + ++L++K + E L +++ L+ V+ + NE K
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-----GMLNEAEGK 1309
Query: 293 PVTVSKGTAT 302
+ ++K A+
Sbjct: 1310 AIKLAKDVAS 1319
Score = 48.5 bits (114), Expect = 2e-05
Identities = 58/286 (20%), Positives = 120/286 (41%), Gaps = 41/286 (14%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+ L+AQ +D F E D + A ++ E + + + + L+ + K
Sbjct: 1654 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARK 1711
Query: 89 QCKNMQERMLSQLAAAESRHRKV----------ILDLEEERQRHAQDTAEGDDVTYMLEK 138
Q +E + +LA++ S + I LEEE + + D +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 139 ERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQL---------SSMLVLECK-- 187
+ E+L+ +L E+S +K E +++L Q +E RS+ ++ S++ LE K
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 188 --------------KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEA 233
AT ++ +K E+ L++E E+ K+ E+ + ++G
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVK 1887
Query: 234 QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEA 279
Q+++QL E + E +++ A + + E E++ + V L++
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKS 1933
Score = 46.2 bits (108), Expect = 9e-05
Identities = 58/268 (21%), Positives = 115/268 (42%), Gaps = 39/268 (14%)
Query: 47 KYNISDPLMALQRDFETLKEK-NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAE 105
K + L+ + L+ K +DGE+ N + + +N E + L AE
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK------VHKLQNEVESVTGMLNEAE 1307
Query: 106 SRHRKVILD-------LEEERQRHAQDTAEGDDVTY---MLEKERERLTQQLEFEKSQVK 155
+ K+ D L++ ++ ++T + +V+ LE+ER L QL+ E +
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 156 KFEKEQKKLSSQLEEERSRHKQLSSML--VLECKKATNKAAEE-----GQKAGELSLKLE 208
E+ L+ QL + + + + +S + + E KK K E +KA KLE
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLE 1426
Query: 209 KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI--------------EREQLRAKLN 254
K K+R+ + ++L + Q + +EK+ +FD ER++ A+
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 255 REENRTKTLKEEMESLKKIVKDLEASHQ 282
+E + +L +E + ++LE +++
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNK 1514
Score = 42.7 bits (99), Expect = 0.001
Identities = 57/282 (20%), Positives = 118/282 (41%), Gaps = 20/282 (7%)
Query: 21 ELEARDLVIEALK-AQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNP 79
E EAR+ +AL A+ + +E + + L A D + K+ + G+
Sbjct: 1482 EAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD-DVGKNVHELEKS 1540
Query: 80 LSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEE-----ERQRHAQDTAEGDDVTY 134
L+ M++ K E + +L A E ++ ++++ ER A+D + ++
Sbjct: 1541 KRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE-QNEEKRR 1599
Query: 135 MLEKERERLTQQLEFEKSQ-------VKKFEKEQKKLSSQLEEE-RSRHKQLSSMLVLEC 186
L+++ +LE E+ Q KK E + K L Q + + R + + + L+
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQA 1659
Query: 187 K-KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIE 245
+ K + E+ + + + KE + +K L A+ + + A E+ + D+E
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLE 1716
Query: 246 REQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPN 287
+E+L +L + L++E L+ + LE + N
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGN 1758
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/262 (23%), Positives = 117/262 (44%), Gaps = 31/262 (11%)
Query: 29 IEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV--CTNPLSIL 83
+ +L +Q +DT EE K N+S L L+ + +L+++ D E + +S L
Sbjct: 1317 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 84 KVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERL 143
+ + K + S + A E ++ ++E Q++ + A D LEK + RL
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRL 1432
Query: 144 TQQLEF-------EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
Q+L+ ++ V EK+Q+K L EE K +SS E +A +A E+
Sbjct: 1433 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEAREK 1488
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
KA L+ LE+ +LE +T ++ ++ + ++ + ++
Sbjct: 1489 ETKALSLARALEEALEAKEELE-----------RTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 257 ENRTKTLKEEMESLKKIVKDLE 278
E + L+ +ME +K +++LE
Sbjct: 1538 EKSKRALETQMEEMKTQLEELE 1559
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 40/275 (14%)
Query: 53 PLMALQRDFETLKEKNDG-----EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAA---- 103
PL+ + R E ++ K D E+Q N L L+ Q + + QL A
Sbjct: 850 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909
Query: 104 -AESRHRKVIL-----DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-------LEFE 150
AE+ +V L +LEE E +D L+ ER+++ QQ LE E
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 151 KSQVKKFEKEQ-------KKLSSQL---EEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
++ +K + E+ KKL ++ +++ ++ + +L T AEE +KA
Sbjct: 970 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQLSEFDIEREQLRAKLNREE 257
L+ K +S +S+LE L E K + E ++E S+F + L+A++ +
Sbjct: 1030 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1089
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+ +EE+++ + D + + N LKK
Sbjct: 1090 MQLAKKEEELQAALARLDD-----EIAQKNNALKK 1119
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/295 (20%), Positives = 123/295 (41%), Gaps = 41/295 (13%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+ L+AQ +D F E D + A ++ E + + + + L+ + K
Sbjct: 1654 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARK 1711
Query: 89 QCKNMQERMLSQLAAAESRHRKV----------ILDLEEERQRHAQDTAEGDDVTYMLEK 138
Q +E + +LA++ S + I LEEE + + D +
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 139 ERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQL---------SSMLVLECK-- 187
+ E+L+ +L E+S +K E +++L Q +E RS+ ++ S++ LE K
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1831
Query: 188 --------------KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEA 233
AT ++ +K E+ L++E E+ K+ E+ + ++G
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVK 1887
Query: 234 QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNE 288
Q+++QL E + E +++ A + + E E++ + V L++ + P E
Sbjct: 1888 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1942
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 34/310 (10%)
Query: 16 SILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEK--- 72
++ E E +A++L K + + +E R K S +++ E LK K +G+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS------RQELEKLKRKLEGDASDF 1074
Query: 73 -QPVCTNPLSILKVVMKQCKNMQE------RMLSQLAAAESRHRKV------ILDLEEE- 118
+ + I ++ M+ K +E R+ ++A + +K+ I DL+E+
Sbjct: 1075 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 119 -RQRHAQDTAEGD--DVTYMLEKERERLTQQLEFEKSQVK---KFEKEQKKLSSQLEEER 172
+R A++ AE D+ LE + L L+ +Q + K E+E L L+EE
Sbjct: 1135 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1194
Query: 173 SRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE 232
H+ + + +A + E+ ++ L+K K + K +LA E + Q +
Sbjct: 1195 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1254
Query: 233 AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+VE + + + + ++L++K + E L +++ L+ V+ + NE K
Sbjct: 1255 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-----GMLNEAEGK 1309
Query: 293 PVTVSKGTAT 302
+ ++K A+
Sbjct: 1310 AIKLAKDVAS 1319
Score = 47.0 bits (110), Expect = 5e-05
Identities = 69/310 (22%), Positives = 137/310 (44%), Gaps = 32/310 (10%)
Query: 12 LTLFSILEGELEARDLVIEA---LKAQHRDTFI-EERYGK--YNISDPLMALQRDFETLK 65
L+L LE LEA++ + LKA+ D ++ GK + + AL+ E +K
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 66 EK-NDGEKQPVCTNPLSI-LKVVMKQCKNMQERMLSQLAAAESRHRKVI--------LDL 115
+ + E + T + L+V M+ K ER L R+ + +L
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 116 EEERQRHAQDTA-----EGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE 170
E+ER++ A A EGD LE + + + E Q++K + + K +LE+
Sbjct: 1613 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1670
Query: 171 ERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAE------ 224
R+ ++ + KKA + A+ Q +L+ E+ + + +EELA E
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQADLEKEELAEELASSLS 1729
Query: 225 RKRGLQTE-AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESL-KKIVKDLEASHQ 282
+ LQ E ++E ++++ + E E+ + + +R + ++ E L ++ + + +
Sbjct: 1730 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1789
Query: 283 HSSPNEQLKK 292
+ S +QL++
Sbjct: 1790 NESARQQLER 1799
Score = 46.2 bits (108), Expect = 9e-05
Identities = 58/268 (21%), Positives = 115/268 (42%), Gaps = 39/268 (14%)
Query: 47 KYNISDPLMALQRDFETLKEK-NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAE 105
K + L+ + L+ K +DGE+ N + + +N E + L AE
Sbjct: 1254 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK------VHKLQNEVESVTGMLNEAE 1307
Query: 106 SRHRKVILD-------LEEERQRHAQDTAEGDDVTY---MLEKERERLTQQLEFEKSQVK 155
+ K+ D L++ ++ ++T + +V+ LE+ER L QL+ E +
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367
Query: 156 KFEKEQKKLSSQLEEERSRHKQLSSML--VLECKKATNKAAEE-----GQKAGELSLKLE 208
E+ L+ QL + + + + +S + + E KK K E +KA KLE
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLE 1426
Query: 209 KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI--------------EREQLRAKLN 254
K K+R+ + ++L + Q + +EK+ +FD ER++ A+
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1486
Query: 255 REENRTKTLKEEMESLKKIVKDLEASHQ 282
+E + +L +E + ++LE +++
Sbjct: 1487 EKETKALSLARALEEALEAKEELERTNK 1514
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 63.5 bits (153), Expect = 6e-10
Identities = 61/262 (23%), Positives = 117/262 (44%), Gaps = 31/262 (11%)
Query: 29 IEALKAQHRDT---FIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPV--CTNPLSIL 83
+ +L +Q +DT EE K N+S L L+ + +L+++ D E + +S L
Sbjct: 1310 VASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 84 KVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERL 143
+ + K + S + A E ++ ++E Q++ + A D LEK + RL
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK----LEKTKNRL 1425
Query: 144 TQQLEF-------EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
Q+L+ ++ V EK+Q+K L EE K +SS E +A +A E+
Sbjct: 1426 QQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE----KNISSKYADERDRAEAEAREK 1481
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
KA L+ LE+ +LE +T ++ ++ + ++ + ++
Sbjct: 1482 ETKALSLARALEEALEAKEELE-----------RTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 257 ENRTKTLKEEMESLKKIVKDLE 278
E + L+ +ME +K +++LE
Sbjct: 1531 EKSKRALETQMEEMKTQLEELE 1552
Score = 52.8 bits (125), Expect = 1e-06
Identities = 66/275 (24%), Positives = 118/275 (42%), Gaps = 40/275 (14%)
Query: 53 PLMALQRDFETLKEKNDG-----EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAA---- 103
PL+ + R E ++ K D E+Q N L L+ Q + + QL A
Sbjct: 843 PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902
Query: 104 -AESRHRKVIL-----DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-------LEFE 150
AE+ +V L +LEE E +D L+ ER+++ QQ LE E
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 151 KSQVKKFEKEQ-------KKLSSQL---EEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
++ +K + E+ KKL ++ +++ ++ + +L T AEE +KA
Sbjct: 963 EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQLSEFDIEREQLRAKLNREE 257
L+ K +S +S+LE L E K + E ++E S+F + L+A++ +
Sbjct: 1023 KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELK 1082
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+ +EE+++ + D + + N LKK
Sbjct: 1083 MQLAKKEEELQAALARLDD-----EIAQKNNALKK 1112
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/295 (20%), Positives = 123/295 (41%), Gaps = 41/295 (13%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMK 88
+ L+AQ +D F E D + A ++ E + + + + L+ + K
Sbjct: 1647 LRKLQAQMKD-FQRELEDARASRDEIFATAKENEKKAKSLEADLMQL-QEDLAAAERARK 1704
Query: 89 QCKNMQERMLSQLAAAESRHRKV----------ILDLEEERQRHAQDTAEGDDVTYMLEK 138
Q +E + +LA++ S + I LEEE + + D +
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 139 ERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQL---------SSMLVLECK-- 187
+ E+L+ +L E+S +K E +++L Q +E RS+ ++ S++ LE K
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIA 1824
Query: 188 --------------KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEA 233
AT ++ +K E+ L++E E+ K+ E+ + ++G
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDER----KMAEQYKEQAEKGNARVK 1880
Query: 234 QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNE 288
Q+++QL E + E +++ A + + E E++ + V L++ + P E
Sbjct: 1881 QLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPPQE 1935
Score = 48.5 bits (114), Expect = 2e-05
Identities = 66/310 (21%), Positives = 136/310 (43%), Gaps = 34/310 (10%)
Query: 16 SILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEK--- 72
++ E E +A++L K + + +E R K S +++ E LK K +G+
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKS------RQELEKLKRKLEGDASDF 1067
Query: 73 -QPVCTNPLSILKVVMKQCKNMQE------RMLSQLAAAESRHRKV------ILDLEEE- 118
+ + I ++ M+ K +E R+ ++A + +K+ I DL+E+
Sbjct: 1068 HEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 119 -RQRHAQDTAEGD--DVTYMLEKERERLTQQLEFEKSQVK---KFEKEQKKLSSQLEEER 172
+R A++ AE D+ LE + L L+ +Q + K E+E L L+EE
Sbjct: 1128 DSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEET 1187
Query: 173 SRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE 232
H+ + + +A + E+ ++ L+K K + K +LA E + Q +
Sbjct: 1188 RSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAK 1247
Query: 233 AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+VE + + + + ++L++K + E L +++ L+ V+ + NE K
Sbjct: 1248 QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-----GMLNEAEGK 1302
Query: 293 PVTVSKGTAT 302
+ ++K A+
Sbjct: 1303 AIKLAKDVAS 1312
Score = 47.0 bits (110), Expect = 5e-05
Identities = 69/310 (22%), Positives = 137/310 (44%), Gaps = 32/310 (10%)
Query: 12 LTLFSILEGELEARDLVIEA---LKAQHRDTFI-EERYGK--YNISDPLMALQRDFETLK 65
L+L LE LEA++ + LKA+ D ++ GK + + AL+ E +K
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 66 EK-NDGEKQPVCTNPLSI-LKVVMKQCKNMQERMLSQLAAAESRHRKVI--------LDL 115
+ + E + T + L+V M+ K ER L R+ + +L
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 116 EEERQRHAQDTA-----EGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE 170
E+ER++ A A EGD LE + + + E Q++K + + K +LE+
Sbjct: 1606 EDERKQRALAAAAKKKLEGD--LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELED 1663
Query: 171 ERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAE------ 224
R+ ++ + KKA + A+ Q +L+ E+ + + +EELA E
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLA-AAERARKQADLEKEELAEELASSLS 1722
Query: 225 RKRGLQTE-AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESL-KKIVKDLEASHQ 282
+ LQ E ++E ++++ + E E+ + + +R + ++ E L ++ + + +
Sbjct: 1723 GRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQK 1782
Query: 283 HSSPNEQLKK 292
+ S +QL++
Sbjct: 1783 NESARQQLER 1792
Score = 46.2 bits (108), Expect = 9e-05
Identities = 58/268 (21%), Positives = 115/268 (42%), Gaps = 39/268 (14%)
Query: 47 KYNISDPLMALQRDFETLKEK-NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAE 105
K + L+ + L+ K +DGE+ N + + +N E + L AE
Sbjct: 1247 KQEVEHKKKKLEAQVQELQSKCSDGERARAELNDK------VHKLQNEVESVTGMLNEAE 1300
Query: 106 SRHRKVILD-------LEEERQRHAQDTAEGDDVTY---MLEKERERLTQQLEFEKSQVK 155
+ K+ D L++ ++ ++T + +V+ LE+ER L QL+ E +
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360
Query: 156 KFEKEQKKLSSQLEEERSRHKQLSSML--VLECKKATNKAAEE-----GQKAGELSLKLE 208
E+ L+ QL + + + + +S + + E KK K E +KA KLE
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYD-KLE 1419
Query: 209 KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI--------------EREQLRAKLN 254
K K+R+ + ++L + Q + +EK+ +FD ER++ A+
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAR 1479
Query: 255 REENRTKTLKEEMESLKKIVKDLEASHQ 282
+E + +L +E + ++LE +++
Sbjct: 1480 EKETKALSLARALEEALEAKEELERTNK 1507
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 63.5 bits (153), Expect = 6e-10
Identities = 56/248 (22%), Positives = 118/248 (47%), Gaps = 26/248 (10%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ 146
M++ ++ Q+ ++ ++ A + ++ LE+ER R + ++ + + LE++R+ QQ
Sbjct: 793 MEEERSRQQEVIGKMEARLNEQSRL---LEQERWRVTAEQSKAESMQRALEEQRKVTAQQ 849
Query: 147 LEFEKSQVKKFE----KEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGE 202
+ E++++++ + +EQK + + EER R + + K + +A E ++A +
Sbjct: 850 MAMERAELERAKSALLEEQKSVMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQ 909
Query: 203 LS-------LKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
+ + L KE++ + EL AE K+ A +E++ E +E+E ++N
Sbjct: 910 VDTQREGTLISLAKEQAELKIRASELRAEEKQLAAERAALEQERQELRLEKE----RINA 965
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTE 315
R K EE+ES+ K+ AS ++ L++ V A + L +V Q E
Sbjct: 966 TALRVKLRAEEVESMSKV-----ASEKYEEGERALREAQQVQ---AEQQARLQAVQQQQE 1017
Query: 316 SFPAERTH 323
+ H
Sbjct: 1018 RLRKQEQH 1025
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/228 (24%), Positives = 102/228 (44%), Gaps = 25/228 (10%)
Query: 92 NMQERMLSQLAAAESRHRKVILDLE------EERQRHAQDTAEGDDVTYMLEKERER--L 143
++Q++ + L ES HR I LE EER R + ++ E E+ R L
Sbjct: 612 SLQQQHQADLELIESAHRSRIKVLETSYQQREERLRRENEELSARYLSQCQEAEQARAEL 671
Query: 144 TQQLEFEKSQVKKFEKEQK-------KLSSQLEEERSRHKQLSSMLVLECKK--ATNKAA 194
T Q + + + + EK+Q+ + +S L+ R +QL + +L+ ++ A A
Sbjct: 672 TAQHQRRLAAIAQ-EKDQEMERLRELQRASILDMRRDHEEQLQRLKLLKDREVDAATSAT 730
Query: 195 EEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLN 254
+ + ++EK S + +L + A L T + E + + D EQLRA
Sbjct: 731 SHTRSLNSIIHQMEKFSSSLHELSSRVEASH---LTTSQERELGIRQRD---EQLRALQE 784
Query: 255 REENRTKTLKEEMESLKKIVKDLEAS-HQHSSPNEQLKKPVTVSKGTA 301
R + + ++EE ++++ +EA ++ S EQ + VT + A
Sbjct: 785 RLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTAEQSKA 832
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 62.4 bits (150), Expect = 1e-09
Identities = 50/214 (23%), Positives = 101/214 (47%), Gaps = 19/214 (8%)
Query: 114 DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERS 173
DL+E+ Q T+E D+ +++E L Q+L+ +K QV++ E + +QLEE+
Sbjct: 41 DLKEKEDTIKQRTSEVQDLQDEVQRENTNL-QKLQAQKQQVQELLDELDEQKAQLEEQ-- 97
Query: 174 RHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEA 233
K+ K AEE Q L +L ++S++S EEELA R + +
Sbjct: 98 ------------LKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR----EELS 141
Query: 234 QVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKP 293
+++++ +E + E +A+L + + ++E+ S++ + +++ H+S P
Sbjct: 142 RLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSP 201
Query: 294 VTVSKGTATEPLMLMSVFCQTESFPAERTHGSNI 327
++ AT+ L + +T + SN+
Sbjct: 202 HSILVNGATDYCSLSTSSSETANLNEHVEGQSNL 235
Score = 31.2 bits (69), Expect = 3.1
Identities = 56/249 (22%), Positives = 102/249 (40%), Gaps = 27/249 (10%)
Query: 18 LEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCT 77
+E +L+ ++ I+ ++ +D E + N+ L A ++ + L ++ D +K +
Sbjct: 38 VEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK-LQAQKQQVQELLDELDEQKAQLEE 96
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAA-------AESRHRKVILDLEEERQRHAQDTAEGD 130
LK V K+C + +++S L A S + + + EE R Q+TAE +
Sbjct: 97 Q----LKEVRKKCAE-EAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELE 151
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFE------KEQKKLSSQLEEERSRHKQLSSMLVL 184
+ + + E L Q L+ + ++ + K+ + +SQL S H L +
Sbjct: 152 ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATD 211
Query: 185 ECKKATNKAAE-------EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEK 237
C +T+ + EGQ E S + +E S E + T A EK
Sbjct: 212 YCSLSTSSSETANLNEHVEGQSNLE-SEPIHQESPARSSPELLPSGVTDENEVTTAVTEK 270
Query: 238 QLSEFDIER 246
SE D R
Sbjct: 271 VCSELDNNR 279
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 61.6 bits (148), Expect = 2e-09
Identities = 81/357 (22%), Positives = 154/357 (43%), Gaps = 59/357 (16%)
Query: 52 DPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKV 111
DP ++ E L+ K + E+ L KV + + ++E L + E R RKV
Sbjct: 529 DPKEKERQRLENLRRKEEAEQ-------LRRQKVEEDKRRRLEEVKLKR----EERLRKV 577
Query: 112 ILDLE-------EERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEK----- 159
+ E E++++ Q A+ D+ T + + ERL ++ +K+ KK E+
Sbjct: 578 LQARERVEQMKEEKKKQIEQKFAQIDEKTE--KAKEERLAEEKAKKKAAAKKMEEVEARR 635
Query: 160 ----EQKKLS-SQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRV 214
E ++L Q EEE RH++L E ++ KAAE A L+ + E+E+
Sbjct: 636 KQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE----AKRLAEQREQERREQ 691
Query: 215 SKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE-ENRTKTLKEEMESLKKI 273
+ E+E E++R Q + E+QL+E + REQ R + RE + R K L+ + E L++
Sbjct: 692 ERREQE-RREQERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRE 750
Query: 274 VKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNIAKMTNT 333
+++ + + E+ + + + A+ G++ A
Sbjct: 751 LEEKKKKEEQQRLAERQLQ--------------------EEQEKKAKEAAGASKALNVTV 790
Query: 334 GLPGPATPAYSYAKTNGHCDPEIQTTR---ELTAGNNVENQVPPREKSVALAQEKPV 387
+ PA +Y P+I +L + ++ +++ PR+ A+ P+
Sbjct: 791 DVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAHPRKPIPTWARGTPL 847
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 61.2 bits (147), Expect = 3e-09
Identities = 72/273 (26%), Positives = 118/273 (43%), Gaps = 32/273 (11%)
Query: 29 IEALKAQHRDTFIEERYGKYNISDPLMA-----------LQRDFETLKEKNDGEKQPVCT 77
I+AL+AQ R T ++ + ++ L + L+R E L K + EK
Sbjct: 2521 IQALRAQLRMTHLQNQEKLQHLRTALTSAEARGSQQEHQLRRQVELLAYKVEQEK----- 2575
Query: 78 NPLSILKVVMKQCKNMQERMLSQ---LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTY 134
I + K QE+ S LAA ++ R + DL E RQ+ Q + +V
Sbjct: 2576 ---CIAGDLQKTLSEEQEKANSVQKLLAAEQTVVRDLKSDLCESRQKSEQLSRSLCEVQQ 2632
Query: 135 MLEKERERLTQQLEFEKSQVKKFEKEQKK---LSSQLEEERSRHKQLSSMLVLECKKATN 191
+ + R L+ + K+ +++ E EQ K L SQLEEE+ RH Q S ++
Sbjct: 2633 EVLQLRSMLSSKENELKAALQELESEQGKGRALQSQLEEEQLRHLQRESQSAKALEELRA 2692
Query: 192 KAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRA 251
+ ++ L + L+ E++ L++EL E R AQ QLSE L+
Sbjct: 2693 SLETQRAQSSRLCVALKHEQTAKDNLQKELRIEHSRCEALLAQERSQLSE-------LQK 2745
Query: 252 KLNREENRTKTLKEEMESLKKIVKDLEASHQHS 284
L E++RT L E + + + + L Q +
Sbjct: 2746 DLAAEKSRTLELSEALRHERLLTEQLSQRTQEA 2778
Score = 56.6 bits (135), Expect = 7e-08
Identities = 59/256 (23%), Positives = 110/256 (42%), Gaps = 21/256 (8%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKV--VMKQCKNMQERMLSQLAAAESRHRKVILD 114
L+ D ++K++ + +C +L++ ++ +N + L +L + + + R +
Sbjct: 2609 LKSDLCESRQKSEQLSRSLCEVQQEVLQLRSMLSSKENELKAALQELESEQGKGRALQSQ 2668
Query: 115 LEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSR 174
LEEE+ RH Q ++ K E L LE +++Q +L L+ E++
Sbjct: 2669 LEEEQLRHLQRESQS-------AKALEELRASLETQRAQ-------SSRLCVALKHEQTA 2714
Query: 175 HKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQ 234
L L +E + A+E + EL L EKSR +L E L ER Q +
Sbjct: 2715 KDNLQKELRIEHSRCEALLAQERSQLSELQKDLAAEKSRTLELSEALRHERLLTEQLSQR 2774
Query: 235 VEKQLSEFDIE-REQLRAKLNREENRTKTLKEEMESLKKIV----KDLEASHQHSSPNEQ 289
++ D + L KL E++R L+ +E +++ + LEA Q +
Sbjct: 2775 TQEACVHQDTQAHHALLQKLKEEKSRVVDLQAMLEKVQQQALHSQQQLEAEAQKHCEALR 2834
Query: 290 LKKPVTVSKGTATEPL 305
+K V+ + + E L
Sbjct: 2835 REKEVSATLKSTVEAL 2850
Score = 45.8 bits (107), Expect = 1e-04
Identities = 61/231 (26%), Positives = 99/231 (42%), Gaps = 35/231 (15%)
Query: 89 QCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLE 148
Q KN ER L L ES H+ I L E+ Q E + + E E+E+ QLE
Sbjct: 396 QDKNQAERALRNL---ESHHQAAIEKLREDLQSEHGRCLEDLEFKFK-ESEKEK---QLE 448
Query: 149 FEKSQVK------KFEKEQKKLSSQLEEERSRHKQLSSMLV-----------LECKKATN 191
E Q + ++E ++L SQL+ R+ ++LS + LE K
Sbjct: 449 LENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQRE 508
Query: 192 KAAEEGQKAGELSLKLEKEKSRVSKLEEE---LAAERKRGLQTEA---QVEKQLSEFDIE 245
K E + +L + EK+ K +E L +R +G + +A VE LS +E
Sbjct: 509 KTQHESELE-QLRIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVEVGLSCVGLE 567
Query: 246 REQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTV 296
+ + + + + + ESL + +LE SH+H E L+ P+ +
Sbjct: 568 EKPEKGRKDHVDELEP--ERHKESLPRFQAELEESHRHQL--EALESPLCI 614
Score = 42.7 bits (99), Expect = 0.001
Identities = 41/168 (24%), Positives = 75/168 (44%), Gaps = 18/168 (10%)
Query: 101 LAAAESRHRKVILDLEEER---QRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKK- 156
LA E +++L+LE R Q+ AQ+ A + L E E ++ ++K
Sbjct: 1351 LAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEAREAALRKE 1410
Query: 157 ---FEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSR 213
KEQ + Q E++RS LS M +LE + + G K+
Sbjct: 1411 VEDLTKEQSETRKQAEKDRSA--LLSQMKILESELEEQLSQHRG---------CAKQAEA 1459
Query: 214 VSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTK 261
V+ LE+++A+ K +++Q +E + ERE+ + ++ R E + +
Sbjct: 1460 VTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLR 1507
Score = 42.4 bits (98), Expect = 0.001
Identities = 60/294 (20%), Positives = 120/294 (40%), Gaps = 41/294 (13%)
Query: 2 NLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMA----- 56
NL+K + L L +L A++L + + QH + E++ + L
Sbjct: 268 NLQKEKETALTELREMLNSR-RAQELALLQSRQQHELELLREQHAREKEEVVLRCGQEAA 326
Query: 57 -----LQRDFE-------TLKEKNDGEKQPVCTNPLSILKVV-MKQCKNMQERMLSQLAA 103
LQ + E TLKE + EK N L + +++Q + +LA
Sbjct: 327 ELKEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRKELSAKHQSEMEDLQNQFQKELAE 386
Query: 104 AESRHRKVILDLEEE----RQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEK 159
+ K+ D + R + A + + L+ E R + LEF KF++
Sbjct: 387 QRAELEKIFQDKNQAERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEF------KFKE 440
Query: 160 EQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEE 219
+K+ +LE ++ ++ L + E ++ ++ ELS E+ +R S++E+
Sbjct: 441 SEKEKQLELENLQASYEDLKAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVED 500
Query: 220 ELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE-ENRTKTLKEEMESLKK 272
E +++ ++ + E EQLR ++ + KT +E++ L++
Sbjct: 501 -----------LEQLKQREKTQHESELEQLRIYFEKKLRDAEKTYQEDLTLLQQ 543
Score = 40.8 bits (94), Expect = 0.004
Identities = 61/257 (23%), Positives = 109/257 (42%), Gaps = 57/257 (22%)
Query: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAA----ESRHRKVILDLEEER 119
L+EK + EKQ + N + + M+Q ++ Q + L + + R +++ DL +
Sbjct: 774 LREKAESEKQTII-NKFELREAEMRQLQDQQAAQILDLERSLTEQQGRLQQLEQDLTSDD 832
Query: 120 QRHAQD------TAEGDDVTYMLEKE----------------RERLTQQLEFEKSQVKKF 157
H TA+ ++ + KE R+ +T++ E+ +
Sbjct: 833 ALHCSQCGREPPTAQDGELAALHVKEDCALQLMLARSRFLEERKEITEKFSAEQDAFLQE 892
Query: 158 EKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEK-----S 212
+EQ QL +ER + + LS LE A ++AA GEL+ LE ++ +
Sbjct: 893 AQEQHARELQLLQERHQQQLLSVTAELE---ARHQAA-----LGELTASLESKQGALLAA 944
Query: 213 RVSKLEEELAAE----RKRGLQTEAQVEK-QLSEFDIEREQLRAKL------------NR 255
RV++L+ + AA+ R L + +E LSEF RE+ R L +
Sbjct: 945 RVAELQTKHAADLGALETRHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKK 1004
Query: 256 EENRTKTLKEEMESLKK 272
+ L +E+E LK+
Sbjct: 1005 DSLHQTILTQELEKLKR 1021
Score = 40.0 bits (92), Expect = 0.007
Identities = 66/274 (24%), Positives = 112/274 (40%), Gaps = 52/274 (18%)
Query: 56 ALQRDFETL-KEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQ----------LAAA 104
AL+++ E L KE+++ KQ S L MK ++ E LSQ + A
Sbjct: 1406 ALRKEVEDLTKEQSETRKQ--AEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTAL 1463
Query: 105 ESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEF---------EKSQVK 155
E + + L +RQ + AE + ++E +RL QL SQ
Sbjct: 1464 EQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLEGQLRQAAKPQPWGPRDSQQA 1523
Query: 156 KFEKE----QKKLSSQLEE--ERSRHKQLSSMLVL----ECKKATNKAAEEGQKAGELSL 205
+ E Q+KL +L+E E + K+ + VL E K+ +K +L
Sbjct: 1524 PLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEEIKRLEEMNINIRKKVAQLQE 1583
Query: 206 KLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFD-----------------IEREQ 248
++EK+K+ V LE++ +K+ + + S D I+ E
Sbjct: 1584 EVEKQKNIVKGLEQDKEVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEV 1643
Query: 249 LRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
+ L R E+ LKE++E +K DLE+ ++
Sbjct: 1644 TQRALLRRESEVLDLKEQLEKMK---GDLESKNE 1674
Score = 38.5 bits (88), Expect = 0.019
Identities = 51/247 (20%), Positives = 99/247 (40%), Gaps = 50/247 (20%)
Query: 43 ERYGKYNISDPLMALQRDFETLKEKNDGEKQ--PVCTNPLSILKVVMKQCKNMQERMLSQ 100
E+ G + ISD QR T+ + ++ + +P + K+C+ E ++
Sbjct: 167 EQRGMFTISDH-QPEQRGMFTVSDHTPEQRGIFTISDHPAEQRGMFTKECEQECELAITD 225
Query: 101 LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE 160
L + E+E H G ++ + T QLE ++ ++K
Sbjct: 226 LESGR----------EDEAGLHQSQAVHGLELEALRLSLSNMHTAQLELTQANLQK---- 271
Query: 161 QKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEE 220
E+ + +L ML ++A EL+L +++ + L E+
Sbjct: 272 ---------EKETALTELREML-------------NSRRAQELALLQSRQQHELELLREQ 309
Query: 221 LAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMES-----LKKIVK 275
A E++ + Q +L +E+L++++ + KTLKE+ ES L+ + K
Sbjct: 310 HAREKEEVVLRCGQEAAEL------KEKLQSEMEKNAQIVKTLKEDWESEKDLCLENLRK 363
Query: 276 DLEASHQ 282
+L A HQ
Sbjct: 364 ELSAKHQ 370
Score = 35.8 bits (81), Expect = 0.12
Identities = 35/127 (27%), Positives = 57/127 (44%), Gaps = 15/127 (11%)
Query: 144 TQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGEL 203
++QLE + +FEKE + + + +H++L LEC K EE EL
Sbjct: 1278 SRQLEEARQIHSRFEKEFSFKNEETAQVVRKHQEL-----LECLK------EESAAKAEL 1326
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTL 263
+L+L K + + + E A+ K L + E +L +E E LR +L + L
Sbjct: 1327 ALELHKTQGTLEGFKVE-TADLKEVLAGKEDSEHRLV---LELESLRRQLQQAAQEQAAL 1382
Query: 264 KEEMESL 270
+EE L
Sbjct: 1383 REECTRL 1389
Score = 35.0 bits (79), Expect = 0.21
Identities = 40/164 (24%), Positives = 76/164 (46%), Gaps = 13/164 (7%)
Query: 125 DTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLS----- 179
+TA+ +V E RL +LE + Q+++ +EQ L + SR + +
Sbjct: 1343 ETADLKEVLAGKEDSEHRLVLELESLRRQLQQAAQEQAALREECTRLWSRGEATATDAEA 1402
Query: 180 --SMLVLECKKATNKAAEEGQKA-GELSLKLEKEKSRVSKLEEELAAERKRGLQTEA--Q 234
+ L E + T + +E ++A + S L + K S+LEE+L+ R Q EA
Sbjct: 1403 REAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAEAVTA 1462
Query: 235 VEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLE 278
+E+Q++ D + LR + + + + E E ++ ++ LE
Sbjct: 1463 LEQQVASLD---KHLRNQRQFMDEQAAEREHEREEFQQEIQRLE 1503
Score = 33.5 bits (75), Expect = 0.62
Identities = 36/155 (23%), Positives = 69/155 (44%), Gaps = 9/155 (5%)
Query: 37 RDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQER 96
R F E+ + K ++ + L ++ E LK K++GE Q V + + +V + +
Sbjct: 994 RADFEEQLWKKDSLHQTI--LTQELEKLKRKHEGELQSVRDHLRT--EVSTELAGTVAHE 1049
Query: 97 MLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKK 156
+ +K L +EE R A+ ++E+E L+ QL+ + QV++
Sbjct: 1050 LQGVHQGEFGSEKKTALHEKEETLRLQSAQAQP-----FHQEEKESLSLQLQKKNHQVQQ 1104
Query: 157 FEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATN 191
+ + LS ++EE RS + L E ++ N
Sbjct: 1105 LKDQVLSLSHEIEECRSELEVLQQRRERENREGAN 1139
Score = 33.5 bits (75), Expect = 0.62
Identities = 42/225 (18%), Positives = 89/225 (39%), Gaps = 32/225 (14%)
Query: 88 KQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQL 147
++C + R + AE+R + ++E+ + ++ + + L + + L +L
Sbjct: 1384 EECTRLWSRGEATATDAEAREAALRKEVEDLTKEQSETRKQAEKDRSALLSQMKILESEL 1443
Query: 148 EFEKSQ----------VKKFEKEQKKLSSQL--------------EEERSRHKQLSSMLV 183
E + SQ V E++ L L E ER +Q L
Sbjct: 1444 EEQLSQHRGCAKQAEAVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRLE 1503
Query: 184 LECKKATN------KAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVE- 236
+ ++A + +++ GE+ L +K + ++ + E + Q Q E
Sbjct: 1504 GQLRQAAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESADRQVLMQEEE 1563
Query: 237 -KQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEAS 280
K+L E +I + A+L E + K + + +E K+++K + S
Sbjct: 1564 IKRLEEMNINIRKKVAQLQEEVEKQKNIVKGLEQDKEVLKKQQMS 1608
Score = 32.0 bits (71), Expect = 1.8
Identities = 67/289 (23%), Positives = 127/289 (43%), Gaps = 49/289 (16%)
Query: 19 EGELEA----RDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDF-ETLKEKNDGEKQ 73
+GEL A D ++ + A+ R F+EER I++ A Q F + +E++ E Q
Sbjct: 848 DGELAALHVKEDCALQLMLARSR--FLEERK---EITEKFSAEQDAFLQEAQEQHARELQ 902
Query: 74 PVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILD--LEEERQRHAQD------ 125
+ L V + + + L +L A+ + +L + E + +HA D
Sbjct: 903 LLQERHQQQLLSVTAELEARHQAALGELTASLESKQGALLAARVAELQTKHAADLGALET 962
Query: 126 ----TAEGDDVTYMLEKE--RERLTQQLE-----FEKSQVKKFEKEQKKLSSQLEEERSR 174
+ + + Y+ E + RE Q LE FE+ KK Q L+ +LE+ + +
Sbjct: 963 RHLSSLDSLESCYLSEFQTIREEHRQALELLRADFEEQLWKKDSLHQTILTQELEKLKRK 1022
Query: 175 HK-QLSSMLV-LECKKATNKAAE-----EGQKAGELSLKLEKEKSRVSKLEEELAAERKR 227
H+ +L S+ L + +T A +G GE ++K+ + + EE L +
Sbjct: 1023 HEGELQSVRDHLRTEVSTELAGTVAHELQGVHQGEFG---SEKKTALHEKEETLRLQ--- 1076
Query: 228 GLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD 276
AQ + E E+E L +L ++ ++ + LK+++ SL +++
Sbjct: 1077 ----SAQAQPFHQE---EKESLSLQLQKKNHQVQQLKDQVLSLSHEIEE 1118
Score = 31.6 bits (70), Expect = 2.3
Identities = 32/136 (23%), Positives = 63/136 (46%), Gaps = 21/136 (15%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ----VKKFEKEQK 162
R +LDL+E+ ++ D ++ E L +L+ + SQ +++ E+E
Sbjct: 1650 RRESEVLDLKEQLEKMKGDLESKNE-------EILHLNLKLDMQNSQTAVSLRELEEENT 1702
Query: 163 KL------SSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSK 216
L SS++EE ++ + L K+ + AEE ++ E+ KL+ E S +
Sbjct: 1703 SLKVIYTRSSEIEELKATIENLQE----NQKRLQKEKAEEIEQLHEVIEKLQHELSLMGP 1758
Query: 217 LEEELAAERKRGLQTE 232
+ E++ + LQ+E
Sbjct: 1759 VVHEVSDSQAGSLQSE 1774
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/172 (26%), Positives = 90/172 (52%), Gaps = 22/172 (12%)
Query: 137 EKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
EKE L QL + + + KE K L ++LE E+ ++ +L+S C K + + E
Sbjct: 475 EKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTS----HCNKLSLENKEL 530
Query: 197 GQKAGELSLKLEKEKSRVS---KLEEELAAERKRGLQTEAQVEKQL----SEFDIEREQL 249
Q+ +++L+L+ ++ ++ K EE + + + +TE Q+ +L E +R+++
Sbjct: 531 TQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEV 590
Query: 250 RAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTA 301
+ KL++ E L++++E+ K +++L+ N+ LKK KGTA
Sbjct: 591 KCKLDKSEENCNNLRKQVENKNKYIEELQ------QENKALKK-----KGTA 631
Score = 55.1 bits (131), Expect = 2e-07
Identities = 63/292 (21%), Positives = 128/292 (43%), Gaps = 27/292 (9%)
Query: 2 NLEKLSKPELLTL------FSILEGELEARDLVIEALK--AQHRDTFIEERYGKYNISDP 53
+LE+L + E L IL EL+ + +E + +++ +EE +
Sbjct: 386 SLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKET 445
Query: 54 LMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVIL 113
L+ + FE + E+ G +Q + + +L+ K+ ++ E L+ + +E + K +
Sbjct: 446 LLYENKQFEKIAEELKGTEQEL----IGLLQAREKEVHDL-EIQLTAITTSEQYYSKEVK 500
Query: 114 DLEEERQRHAQDTAEGDDVTYMLEKERERLTQ-------QLEFEKSQVKKFEKEQKKLSS 166
DL+ E + E L E + LTQ +L+ ++ + +K+++++
Sbjct: 501 DLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLK 560
Query: 167 QLEEERSRHKQLSSMLVL---ECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAA 223
Q+E + QL + L E K+ ++ + K+ E L K+ +K EEL
Sbjct: 561 QIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQ 620
Query: 224 ERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENR----TKTLKEEMESLK 271
E K + KQL+ ++I+ +L +L + + T T ++E+E K
Sbjct: 621 ENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKK 672
Score = 54.3 bits (129), Expect = 3e-07
Identities = 69/302 (22%), Positives = 135/302 (44%), Gaps = 35/302 (11%)
Query: 8 KPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEK 67
+ E ++ L +E E L+ Q ++ +E + + + L+++++ KE
Sbjct: 204 REETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYK--KEI 261
Query: 68 NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
ND EKQ +S+L + + + +N + + L ESR + + LEE+ + +++
Sbjct: 262 NDKEKQ------VSLLLIQITEKENKMKDLTFLLE--ESRDK--VNQLEEKTKLQSENLK 311
Query: 128 EGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK 187
+ +EK+ LT++LE K +++ QK L L Q+++ + +
Sbjct: 312 QS------IEKQHH-LTKELEDIKVSLQRSVSTQKALEEDL--------QIATKTICQLT 356
Query: 188 KATNKAAEEGQKAGEL-SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIER 246
+ EE KA S + + ++ V LEE L E++R + E QL +E
Sbjct: 357 EEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNE----DQLKILTMEL 412
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLM 306
++ ++L T + E+E LKK++ + E N+Q +K KGT E +
Sbjct: 413 QKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYE---NKQFEKIAEELKGTEQELIG 469
Query: 307 LM 308
L+
Sbjct: 470 LL 471
Score = 48.1 bits (113), Expect = 2e-05
Identities = 85/299 (28%), Positives = 134/299 (44%), Gaps = 48/299 (16%)
Query: 4 EKLSKPELLT---LFSILEGEL--EARDLVIEALKAQHRDTFI----EERYGKY--NISD 52
EKL EL + S+ EL E D+ +E LK Q D EER K N+ +
Sbjct: 509 EKLKNTELTSHCNKLSLENKELTQETSDMTLE-LKNQQEDINNNKKQEERMLKQIENLQE 567
Query: 53 PLMALQRDFE----TLKEKNDGEK------QPVCTNPLSILKVVMKQCKNMQE--RMLSQ 100
L+ + E LK+K D K + C N ++ K + +Q+ + L +
Sbjct: 568 TETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKK 627
Query: 101 LAAAESRH--------RKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-LEFEK 151
AES+ K+ L+LE +Q+ + T TY E E ++++++ L E
Sbjct: 628 KGTAESKQLNVYEIKVNKLELELESAKQKFGEITD-----TYQKEIEDKKISEENLLEEV 682
Query: 152 SQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT-NKAAEEGQKAGELSLKLEKE 210
+ K E KL ++++ R +HK + ++E K +K EE + EL L KE
Sbjct: 683 EKAKVIADEAVKLQKEIDK-RCQHKIAEMVALMEKHKHQYDKIIEE--RDSELGLYKSKE 739
Query: 211 KSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE-ENRTKTLKEEME 268
+ + S L L E V+KQL +IERE+ + KL RE + T TLKE+ +
Sbjct: 740 QEQ-SSLRASLEIELSNLKAELLSVKKQL---EIEREE-KEKLKREAKENTATLKEKKD 793
Score = 47.4 bits (111), Expect = 4e-05
Identities = 63/266 (23%), Positives = 110/266 (41%), Gaps = 31/266 (11%)
Query: 12 LTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGE 71
L L I E E + +DL +EE K N + LQ E LK+ E
Sbjct: 270 LLLIQITEKENKMKDLTF----------LLEESRDKVNQLEEKTKLQS--ENLKQSI--E 315
Query: 72 KQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDD 131
KQ T L +KV +++ + Q+ + L A K I L EE++ +++ +
Sbjct: 316 KQHHLTKELEDIKVSLQRSVSTQKALEEDLQIAT----KTICQLTEEKETQMEESNKARA 371
Query: 132 VTYMLEKERER----LTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK 187
+ E E L + L E+ +++K E + K L+ +L+++ S ++++ K
Sbjct: 372 AHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMT-------K 424
Query: 188 KATNKAAEEGQKAGELSLK--LEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIE 245
NK E + L K L E + K+ EEL + + EK++ + +I+
Sbjct: 425 LTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQ 484
Query: 246 REQLRAKLNREENRTKTLKEEMESLK 271
+ K LK E+E+ K
Sbjct: 485 LTAITTSEQYYSKEVKDLKTELENEK 510
Score = 47.4 bits (111), Expect = 4e-05
Identities = 70/310 (22%), Positives = 124/310 (40%), Gaps = 72/310 (23%)
Query: 23 EARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSI 82
E +DL E + ++T + K ++ + + + TL+ KN E
Sbjct: 498 EVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQED---------- 547
Query: 83 LKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERER 142
+ K +ERML Q+ + ++ +LE R+ Q + D+V L+K E
Sbjct: 548 ----INNNKKQEERMLKQIENLQETETQLRNELEYVREELKQ---KRDEVKCKLDKSEEN 600
Query: 143 ---LTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLS------SMLVLECKKATNKA 193
L +Q+E + +++ ++E K L + E KQL+ + L LE + A K
Sbjct: 601 CNNLRKQVENKNKYIEELQQENKALKKKGTAES---KQLNVYEIKVNKLELELESAKQKF 657
Query: 194 AE---------EGQKAGELSLKLEKEKSRV-----------------SKLEEELAAERKR 227
E E +K E +L E EK++V K+ E +A K
Sbjct: 658 GEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKH 717
Query: 228 GLQTEAQVEKQLSEF-----------------DIEREQLRAKLNREENRTKTLKEEMESL 270
Q + +E++ SE +IE L+A+L + + + +EE E L
Sbjct: 718 KHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKL 777
Query: 271 KKIVKDLEAS 280
K+ K+ A+
Sbjct: 778 KREAKENTAT 787
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 60.8 bits (146), Expect = 4e-09
Identities = 50/203 (24%), Positives = 96/203 (47%), Gaps = 20/203 (9%)
Query: 91 KNMQERMLSQLAA-AESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEF 149
++ QER QL E R+ L LEEE +R Q E+ ++L ++ E
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ------------ERREQQLRREQEE 513
Query: 150 EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEK 209
+ Q K ++E+++L +L E+ ++ K+ K E+ ++ L + E+
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 210 EKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMES 269
+ ++ K EEE +R + Q E ++E++L ++ER L +EE R + LK E
Sbjct: 574 RRDQLLKREEERRQQRLKREQ-EERLEQRLKREEVER------LEQEERREQRLKREEPE 626
Query: 270 LKKIVKDLEASHQHSSPNEQLKK 292
++ + L++ Q +QL++
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRR 649
Score = 57.8 bits (138), Expect = 3e-08
Identities = 65/296 (21%), Positives = 130/296 (43%), Gaps = 26/296 (8%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFET 63
E+ E L +LE + R+ + + + F EE ++ + + L+++ E
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV--LRKEEEK 259
Query: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNM---QERMLSQLAAAESRHRKVILDLEEERQ 120
L+E+ ++ + + K+ ++ + +E+ +L + RK EEER+
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ----EEERR 315
Query: 121 RHAQDTAEGDDVTYMLEKERER-LTQQLEFEKSQVKKFEKEQKKLSSQL---EEERSRHK 176
++ E + E+ RE+ L ++ E + Q + E+E+++ QL +EE R +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 177 QLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVE 236
QL + + E Q E L+ E++ R +L E R++ L+ E Q+
Sbjct: 376 QL---------RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 237 KQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
++ E ER + + + R E R K +EE K ++ E H+ +QLK+
Sbjct: 427 REQEE---ERHEQKHEQERREQRLKREQEERRDWLKREEETE-RHEQERRKQQLKR 478
Score = 57.4 bits (137), Expect = 4e-08
Identities = 56/242 (23%), Positives = 112/242 (46%), Gaps = 22/242 (9%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSI-----LKVVMKQCKNMQERMLSQLAAAESRHRKV 111
L+R+ ET + + + KQ + + LK+ ++ + QER QL + R+
Sbjct: 458 LKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 112 ILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEE 171
L +EE +R Q + E+ RE+L ++ + K+ E+E+++ + E+E
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQL-----LKREEEKRLEQERREQRLKREQE 572
Query: 172 RSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLE-EELAAERKRGLQ 230
R + L K+ + + ++ E L+ ++ V +LE EE +R + +
Sbjct: 573 ERRDQLL--------KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREE 624
Query: 231 TEAQVEKQL--SEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNE 288
E + +QL SE ER Q + + ++E R + LK E E +++ + L+ H+ +
Sbjct: 625 PEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEE-ERLEQRLKREHEEERREQ 683
Query: 289 QL 290
+L
Sbjct: 684 EL 685
Score = 52.8 bits (125), Expect = 1e-06
Identities = 49/199 (24%), Positives = 93/199 (46%), Gaps = 24/199 (12%)
Query: 91 KNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE 150
+ Q R QL + R+ L E+E +RH Q E + L++E+E L+ E
Sbjct: 403 REQQLRREQQLRREQQLRREQQLRREQEEERHEQ-KHEQERREQRLKREQEERRDWLKRE 461
Query: 151 KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKE 210
+ + ++ E+E++K + ++E R ++ K + E Q+ E L+ E+E
Sbjct: 462 E-ETERHEQERRKQQLKRDQEEERRER--------WLKLEEEERREQQERREQQLRREQE 512
Query: 211 KSRVSKLEEELAAER-KRGLQTEAQVEKQLSE-------------FDIEREQLRAKLNRE 256
+ R +L+ + ER ++ L++E Q+ ++ E + ER + R K +E
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE 572
Query: 257 ENRTKTLKEEMESLKKIVK 275
E R + LK E E ++ +K
Sbjct: 573 ERRDQLLKREEERRQQRLK 591
Score = 51.2 bits (121), Expect = 3e-06
Identities = 56/215 (26%), Positives = 105/215 (48%), Gaps = 21/215 (9%)
Query: 91 KNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE 150
K+ QER +L E R+ L EEE +RH Q+ + ++E ER + L+ E
Sbjct: 437 KHEQERREQRLKR-EQEERRDWLKREEETERHEQERRKQQ---LKRDQEEERRERWLKLE 492
Query: 151 KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKE 210
+ + ++ ++E+++ + E+E R ++L K+ + + + E L+ E+E
Sbjct: 493 EEE-RREQQERREQQLRREQEERREQRL--------KRQEEEERLQQRLRSEQQLRREQE 543
Query: 211 KSR--VSKLEEELAAERKRGLQ----TEAQVEKQLSEFDIEREQLRAKLNREENRTKTLK 264
+ R + K EEE E++R Q + + QL + + ER Q R K +EE + LK
Sbjct: 544 ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Query: 265 -EEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSK 298
EE+E L++ + E + P E+ ++ + S+
Sbjct: 604 REEVERLEQ-EERREQRLKREEPEEERRQQLLKSE 637
Score = 50.4 bits (119), Expect = 5e-06
Identities = 42/191 (21%), Positives = 95/191 (49%), Gaps = 17/191 (8%)
Query: 117 EERQRHAQDTAEGDDVTYMLE----KERERLTQQL-----EFEKSQVKKFEKEQ-KKLSS 166
++RQ ++ AEG++ + E ++R+R ++L E+++ + ++ E+EQ +
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Query: 167 QLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERK 226
EE +QL +LE ++ + ++ ++ + + E+E+ K E L E +
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 227 RGLQTEAQVEKQLSEFD-----IEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASH 281
+ + E Q +++L E + +ER++LR + EE + + L+ E + +K ++ E
Sbjct: 259 KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRK--QEEERRE 316
Query: 282 QHSSPNEQLKK 292
Q EQ ++
Sbjct: 317 QQEERREQQER 327
Score = 50.1 bits (118), Expect = 6e-06
Identities = 53/204 (25%), Positives = 99/204 (48%), Gaps = 15/204 (7%)
Query: 88 KQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQL 147
+Q + QE QL E R LE+ER+ + + +L++E ER Q+L
Sbjct: 536 QQLRREQEERREQLLKREEEKR-----LEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 148 EFEKSQVKKFEKEQKKLS-SQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLK 206
+ E Q ++ E+ K+ +LE+E R ++L E ++ +EE ++ + L+
Sbjct: 591 KRE--QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Query: 207 LEKEKSRVSKLEEELAAER-KRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKE 265
E+++ R +L+ E ER ++ L+ E + E++ E E EQ +A+ R ++R +
Sbjct: 649 REQQERREQRLKREEEEERLEQRLKREHEEERREQEL-AEEEQEQAR-ERIKSRIPKWQW 706
Query: 266 EMESLKKIVKDLEASHQHSSPNEQ 289
++ES D S +S P +Q
Sbjct: 707 QLES----EADARQSKVYSRPRKQ 726
Score = 48.5 bits (114), Expect = 2e-05
Identities = 47/206 (22%), Positives = 98/206 (47%), Gaps = 12/206 (5%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
QER +L + R +L EEER++ + + + L++E +Q E + +
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Query: 154 VKKFEKEQKKLSSQL--EEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEK 211
+K+ E E+++ L EE+ R +Q E ++ K EE ++ E LK E E+
Sbjct: 620 LKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL-EQRLKREHEE 678
Query: 212 SR----VSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEM 267
R +++ E+E A ER + + Q + + SE D + ++ ++ ++E + + ++E
Sbjct: 679 ERREQELAEEEQEQARERIKSRIPKWQWQLE-SEADARQSKVYSRPRKQEGQRRRQEQEE 737
Query: 268 ESLKKIV----KDLEASHQHSSPNEQ 289
+ ++ ++ E +H+ EQ
Sbjct: 738 KRRRRESELQWQEEERAHRQQQEEEQ 763
Score = 46.6 bits (109), Expect = 7e-05
Identities = 57/213 (26%), Positives = 95/213 (44%), Gaps = 34/213 (15%)
Query: 93 MQERMLSQLAAAE--SRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKE----RERLTQQ 146
++E+ QL A E R ++ + + EE+ QR Q ++ ++ E+E RER Q
Sbjct: 790 LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849
Query: 147 LEFE----KSQVKKFEKEQK---KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQK 199
E E + Q ++ +EQ+ K QLEEER R + L K A
Sbjct: 850 QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRH-----TLYAKPA---------- 894
Query: 200 AGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENR 259
L +L KE+ + + EEEL E + + + Q + E +++E+ +L REE R
Sbjct: 895 ---LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE--EQLLREE-R 948
Query: 260 TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
K ++E E + K L+ + E K+
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Score = 46.2 bits (108), Expect = 9e-05
Identities = 46/184 (25%), Positives = 91/184 (49%), Gaps = 22/184 (11%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ 146
++Q ++ + R Q + + R RK EEE+Q Q E+ER+ L ++
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKF---REEEQQVRRQ------------ERERKFLEEE 1452
Query: 147 LEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLK 206
+ + + +KF +E++ L Q EE+ H+Q LE ++ + E +K E L+
Sbjct: 1453 QQLRQERHRKFREEEQLL--QEREEQQLHRQERDRKFLE-EEQQLRRQERDRKFREQELR 1509
Query: 207 LEKEKSRVSKLEEELAAE--RKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLK 264
++ + + + E++L + +++ LQ E Q+ +Q E +R Q R + REE + + +
Sbjct: 1510 SQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ--ERGQQRRQDRDRKFREEEQLRQER 1567
Query: 265 EEME 268
EE +
Sbjct: 1568 EEQQ 1571
Score = 46.2 bits (108), Expect = 9e-05
Identities = 53/243 (21%), Positives = 109/243 (44%), Gaps = 38/243 (15%)
Query: 30 EALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ 89
+ L+ Q RD E L +R+ + L+E+ +Q L+ ++
Sbjct: 1682 QQLRRQERDRKFREE------EQQLRRQERERKFLQEEQQLRRQE--------LERKFRE 1727
Query: 90 CKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEF 149
+ +++ + + R+RK+ LEEE+ R ++ + + +ER+R +F
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKI---LEEEQLRPEREEQQ------LRRQERDR-----KF 1773
Query: 150 EKSQVKKFEKEQKKLSSQ------LEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGEL 203
+ + + E+E+++L SQ EEE+ R ++ L + + + EE + E
Sbjct: 1774 REEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTL 263
+L +E+ R + EE+ A + K + + ++ E + +R Q R + REE+ +
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEK----SRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 264 KEE 266
KEE
Sbjct: 1890 KEE 1892
Score = 45.4 bits (106), Expect = 2e-04
Identities = 58/273 (21%), Positives = 117/273 (42%), Gaps = 36/273 (13%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFET 63
EKL + E + E E + R L + L+ + ++ E++ + L Q +
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEE--EQQQQRLRREQQLRRKQEEERR 315
Query: 64 LKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHA 123
+++ E+Q ++ + +ER QL + R+ L E+E +R
Sbjct: 316 EQQEERREQQ--------------ERREQQEERREQQLRREQEERREQQLRREQEEERRE 361
Query: 124 QDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV 183
Q E+E ER QQL E+ Q+++ ++ +++ + E++ R +QL
Sbjct: 362 QQLRR--------EQEEERREQQLRREQ-QLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Query: 184 L----ECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQL 239
L + ++ E+ ++ E + E+ + R+ + +E ER+ L+ E + E+
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE----ERRDWLKREEETERHE 468
Query: 240 SEFDIEREQLRAKLNREENRTKTLKEEMESLKK 272
E R+Q + EE R + LK E E ++
Sbjct: 469 QE---RRKQQLKRDQEEERRERWLKLEEEERRE 498
Score = 45.4 bits (106), Expect = 2e-04
Identities = 43/209 (20%), Positives = 98/209 (46%), Gaps = 17/209 (8%)
Query: 86 VMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQ 145
+ +Q + Q+ + + + R+ E+ERQ ++ + ++ + E+ +R Q
Sbjct: 895 LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 146 QLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL 205
+ E + + KK ++++++L + E+R R + ++ + EE Q+ E L
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQE----------REKKYREEEELQQEEEQLL 1004
Query: 206 KLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQL--RAKLNREENRTKTL 263
+ E+EK R + E + +K LQ E E+QL + E+ +L R + REE +
Sbjct: 1005 REEREKRRRQEWERQY--RKKDELQQE---EEQLLREEREKRRLQERERQYREEEELQQE 1059
Query: 264 KEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+E++ ++ + + + E+L++
Sbjct: 1060 EEQLLGEERETRRRQELERQYRKEEELQQ 1088
Score = 45.4 bits (106), Expect = 2e-04
Identities = 46/201 (22%), Positives = 96/201 (47%), Gaps = 13/201 (6%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
+E+ L Q + R + +L EE+Q H Q E D E++ R + +F + +
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQ---ERDRKFLEEEQQLRRQERDRKFREQE 1507
Query: 154 VKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKL-EKEKS 212
++ E E+K L EEE+ H+Q L+ ++ + Q+ + K E+E+
Sbjct: 1508 LRSQEPERKFL----EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL 1563
Query: 213 RVSKLEEELA-AERKRGLQTEAQV---EKQLSEFDIEREQLRAKLNREENRTKTLKEEME 268
R + E++L+ ER R + E Q ++Q +F + +QLR + +++ R + ++ E
Sbjct: 1564 RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFRE 1623
Query: 269 SLKKIVKDLEASHQHSSPNEQ 289
++++++ E H ++
Sbjct: 1624 D-EQLLQEREEQQLHRQERDR 1643
Score = 44.7 bits (104), Expect = 3e-04
Identities = 42/175 (24%), Positives = 83/175 (47%), Gaps = 7/175 (4%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQ 153
QER SQ + R +K LEEER+R + L KE++ L Q E E+ Q
Sbjct: 860 QERRRSQ---EQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLL--QEEEEELQ 914
Query: 154 VKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSR 213
++ EK +++ + E + +Q L+ E ++ + E Q + L+ ++E+
Sbjct: 915 REEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLL 974
Query: 214 VSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEME 268
+ E+ ER++ + E +++++ E + RE+ + +E R K+E++
Sbjct: 975 GEEPEKRRRQEREKKYREEEELQQE--EEQLLREEREKRRRQEWERQYRKKDELQ 1027
Score = 44.3 bits (103), Expect = 3e-04
Identities = 41/205 (20%), Positives = 97/205 (47%), Gaps = 7/205 (3%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDT----AEGDDVTYMLEKERERLTQQLEF 149
+E+ L + R + +L EE+Q Q+ E + E+ER+ L ++ +
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 150 EKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKL-E 208
+ ++++ +E+++L + E+E+ R +Q +LE ++ + E+ + E K E
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLR-RQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 209 KEKSRVSKLEEEL-AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEM 267
+E+ R + E++L + E R + E Q+ ++ E + +Q K EE + + ++E
Sbjct: 1776 EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835
Query: 268 ESLKKIVKDLEASHQHSSPNEQLKK 292
++ + A Q ++ + ++
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRRE 1860
Score = 42.4 bits (98), Expect = 0.001
Identities = 50/216 (23%), Positives = 99/216 (45%), Gaps = 15/216 (6%)
Query: 88 KQCKNMQERMLSQLAAAESRHR--KVILDLEEERQRHAQDTAEGDDVTYMLEKERE-RLT 144
K+ + +E++L + R K + EE +Q Q E + E ER+ R
Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Query: 145 QQLEFEKSQVKKFEKEQKKLSSQLEEERSRH--KQLSSMLVLECKKATNKAAEEGQKAGE 202
+L+ E+ Q+ + E+E+++L + + R +Q L+ E ++ + E Q E
Sbjct: 1024 DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKE 1083
Query: 203 LSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQLSEFDIEREQLRAKLNREENR 259
L+ E+E+ + E+ ER+R + E Q E+QL + E+ + R +L R+
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR-RQELERQYRE 1142
Query: 260 TKTLKEEMESL------KKIVKDLEASHQHSSPNEQ 289
+ +++E E L K+ ++LE ++ +Q
Sbjct: 1143 EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Score = 42.0 bits (97), Expect = 0.002
Identities = 54/252 (21%), Positives = 113/252 (44%), Gaps = 25/252 (9%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVM-KQCKNMQERMLS--QLAAAESRHRKVIL 113
L+R + +E E+Q + P + +QC+ +E QL E R+
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR--- 1132
Query: 114 DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEER- 172
E ERQ ++ + ++ + E+ +R Q+LE + + ++ ++E+++L + +E+R
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 173 -SRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKE------------KSRVSKLEE 219
R +Q L+ +K + +E Q++ +L + E E K R ++
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 220 ELAAERKRGLQTEAQVEKQLSE-FDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLE 278
+L + R Q++ ++ L E + +REQ R R + R + EE + ++ K+ +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQER---RRWQQRDRHFPEEEQLEREEQKEAK 1308
Query: 279 ASHQHSSPNEQL 290
+ S +QL
Sbjct: 1309 RRDRKSQEEKQL 1320
Score = 42.0 bits (97), Expect = 0.002
Identities = 49/210 (23%), Positives = 93/210 (44%), Gaps = 28/210 (13%)
Query: 105 ESRHRKVIL--DLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEK---------SQ 153
+S+ K +L + EE+R+R D ++ + E+E + L +Q K Q
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 154 VKKFEKEQKKLSSQ------LEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKL 207
+KF +E+++L Q L+EE+ Q + + + + E+ E K
Sbjct: 1373 GRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKF 1432
Query: 208 EKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQL-----RAKLNREENRTKT 262
+E+ +V + E E ++ L+ E Q+ ++ E EQL +L+R+E K
Sbjct: 1433 REEEQQVRRQERE-----RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKF 1487
Query: 263 LKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
L+EE + L++ +D + Q E +K
Sbjct: 1488 LEEE-QQLRRQERDRKFREQELRSQEPERK 1516
Score = 42.0 bits (97), Expect = 0.002
Identities = 44/188 (23%), Positives = 86/188 (45%), Gaps = 16/188 (8%)
Query: 88 KQCKNMQERMLSQLAAAESRHRKVILDLEEERQ-RHAQDTAEGDDVTYMLEKERERLTQQ 146
+Q ++ + R Q + R RK LEEE+Q R + ++ + E+E ++L +Q
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKF---LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQ 1481
Query: 147 ------LEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
LE E+ Q+++ E+++K +L + K L L ++ K +E Q+
Sbjct: 1482 ERDRKFLE-EEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRT 260
++ + R K EE E+ R + E Q+ +Q + E+ K+ R+E
Sbjct: 1541 RRQERGQQRRQDRDRKFREE---EQLRQEREEQQLSRQERDRKFRLEE--QKVRRQEQER 1595
Query: 261 KTLKEEME 268
K +++E +
Sbjct: 1596 KFMEDEQQ 1603
Score = 41.2 bits (95), Expect = 0.003
Identities = 50/203 (24%), Positives = 89/203 (43%), Gaps = 35/203 (17%)
Query: 94 QERMLSQLAAAESRHR------KVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQL 147
++R L + E R R K + LEEE Q ++ A+ L++E + L +
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ------QLQEEEDGLQEDQ 860
Query: 148 EFEKSQVKK--------FEKEQKK----------LSSQLEEERSRHKQLSSMLVLECKKA 189
E +SQ ++ E+E+K+ L QL +E+ ++ L E ++
Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREK 920
Query: 190 TNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE---AQVEKQL--SEFDI 244
+ +E Q E L+ E+E+ + E+ ER+R + + Q E+QL E +
Sbjct: 921 RRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEK 980
Query: 245 EREQLRAKLNREENRTKTLKEEM 267
R Q R K REE + +E++
Sbjct: 981 RRRQEREKKYREEEELQQEEEQL 1003
Score = 41.2 bits (95), Expect = 0.003
Identities = 55/241 (22%), Positives = 109/241 (45%), Gaps = 45/241 (18%)
Query: 88 KQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQ-------DTAEGDDVTYMLEKER 140
+Q ++ + R+ Q + + RK + D ++ R++ Q D +D + E+E
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 141 ERLTQQ------LEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAA 194
++L +Q LE E+ Q+++ E+EQ QL +R R + L+ E ++ +
Sbjct: 1634 QQLHRQERDRKFLE-EEPQLRRQEREQ-----QLRHDRDRKFREEEQLLQEGEEQQLRRQ 1687
Query: 195 EEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLN 254
E +K E +L +++ L+EE R+ L+ + + E+QL + + E+EQLR +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQE-LERKFREEEQLRQ-ETEQEQLRRQER 1745
Query: 255 -------------------REENRTKTLKEEMESLKKIVKDLEASHQHSS----PNEQLK 291
R + R + +EE E L++ ++ + Q S EQL+
Sbjct: 1746 YRKILEEEQLRPEREEQQLRRQERDRKFREE-EQLRQEREEQQLRSQESDRKFREEEQLR 1804
Query: 292 K 292
+
Sbjct: 1805 Q 1805
Score = 40.0 bits (92), Expect = 0.007
Identities = 48/199 (24%), Positives = 90/199 (45%), Gaps = 41/199 (20%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERE-RLTQQLEFEKSQVKKFEKEQKKLS 165
+ ++++ + EEE QR ++ E+ER+ R +QL+ E+ Q+ + E+E+++
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQ------EQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 166 S---QLEEERSRHKQLSSMLVLECKKATN-------KAAEEGQKAGELSLKLEKEKSR-- 213
Q +++ ++ +L E +K + EE Q+ E L+ E+EK R
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQ 1014
Query: 214 -----------VSKLEEELAAE--RKRGLQTEAQVEKQLSEFDIEREQL---------RA 251
+ + EE+L E KR LQ + ++ E E EQL R
Sbjct: 1015 EWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 252 KLNREENRTKTLKEEMESL 270
+L R+ + + L++E E L
Sbjct: 1075 ELERQYRKEEELQQEEEQL 1093
Score = 39.3 bits (90), Expect = 0.011
Identities = 40/159 (25%), Positives = 74/159 (46%), Gaps = 12/159 (7%)
Query: 115 LEEERQRHAQDTAEGDDVTYMLEKERERLTQQL---EFEKSQVKKFEKEQKKLSSQLEEE 171
L EER++ E Y E+E ++ +QL E E + ++ E++ +K +EE
Sbjct: 1034 LREEREKRRLQERERQ---YREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 172 RSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQT 231
++ + ++ + EE Q+ E L+ E+EK R +LE + E +
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE-----EE 1145
Query: 232 EAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESL 270
Q E+QL + E+ + R +L R+ + L++E E L
Sbjct: 1146 VQQEEEQLLREEPEKRR-RQELERQYREEEELQQEEEQL 1183
Score = 39.3 bits (90), Expect = 0.011
Identities = 52/238 (21%), Positives = 100/238 (42%), Gaps = 30/238 (12%)
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLE 116
L+R + +E E+Q +L+ ++ + +ER + + + RK E
Sbjct: 1166 LERQYREEEELQQEEEQ--------LLREEQEKRRQERERQYREEEELQRQKRKQRYRDE 1217
Query: 117 EERQ------RHAQDTAEGDDVTYMLEKERERLTQ----QLEFEKSQ--VKKFEKEQKKL 164
++R ++ A D+ Y +E E+ Q QL +SQ ++ EQ++
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 165 SSQLE----EERSRH----KQLSSMLVLECKKATNKAAEEGQKAGEL--SLKLEKEKSRV 214
+ E ++R RH +QL E K+ K+ EE Q E + +E R
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK 1337
Query: 215 SKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKK 272
+ EE+L ER+ + +++ E ++ ++ K EE R + + E + LK+
Sbjct: 1338 FREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE 1395
Score = 38.1 bits (87), Expect = 0.025
Identities = 46/189 (24%), Positives = 83/189 (43%), Gaps = 35/189 (18%)
Query: 115 LEEERQRHAQDTA-----EGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLE 169
LEEE+Q H Q E + ++ R + +F + + + E+E+++LS Q
Sbjct: 1518 LEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ-- 1575
Query: 170 EERSRHKQLSSMLVLECKKATNKAAEEGQ-KAGELSLKLEKEKSRVSKLEEELAAER--- 225
ER R +L V ++ +E Q + E +L +E+ R + +E+L ER
Sbjct: 1576 -ERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Query: 226 --------KRGLQTEAQVEKQLSEFDI---------EREQL-----RAKLNREENRTKTL 263
++ L+ E Q+ +Q E + E EQL +L R+E R +
Sbjct: 1635 QLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQE-RDRKF 1693
Query: 264 KEEMESLKK 272
+EE + L++
Sbjct: 1694 REEEQQLRR 1702
Score = 36.6 bits (83), Expect = 0.073
Identities = 45/279 (16%), Positives = 125/279 (44%), Gaps = 23/279 (8%)
Query: 30 EALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ 89
+ LK + + +E+R + + + +R+ E +E+ + ++ + + + +
Sbjct: 657 QRLKREEEEERLEQRLKREHEEE-----RREQELAEEEQEQARERIKSRIPKWQWQLESE 711
Query: 90 CKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEF 149
Q ++ S+ E + R+ + EE+R+R + ++ +++ E + +
Sbjct: 712 ADARQSKVYSRPRKQEGQRRRQ--EQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTW 769
Query: 150 EKSQVKKFEKEQKKLSSQ--LEEERSR------HKQLSSMLVLECKKATNKAAEEGQKAG 201
+ +K E+ +++LS++ L E+R R +Q + E ++ + + ++
Sbjct: 770 QWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREK 829
Query: 202 ELSLKLEKE----KSRVSKLEEE----LAAERKRGLQTEAQVEKQLSEFDIEREQLRAKL 253
EL E+E + R +L+EE + +R Q + + +K + + ER++ R L
Sbjct: 830 ELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTL 889
Query: 254 NREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
+ + L++E + L++ ++L+ + ++ ++
Sbjct: 890 YAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Score = 36.2 bits (82), Expect = 0.095
Identities = 49/211 (23%), Positives = 94/211 (44%), Gaps = 26/211 (12%)
Query: 88 KQCKNMQERML--SQLAAAESRHRKVILDLEEERQRHAQ---DTAEGDDVTYMLEKERER 142
++ + +E++L Q + R R+ + E +RQ+ Q D + D+ + E E+E
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 143 LTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGE 202
+ K K E EQ + QLE+ + R +Q L + + E+ ++ +
Sbjct: 1234 AVRD---NKVYCKGRENEQFR---QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 203 L-------SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDI---EREQLRAK 252
+LE+E+ + +K + + E K+ L+ E + +++ E D E EQL +
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 253 -----LNREENRTKTLKEEMESLKKIVKDLE 278
L R+E K +EE+ ++ K LE
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLE 1378
Score = 31.6 bits (70), Expect = 2.3
Identities = 19/78 (24%), Positives = 40/78 (51%), Gaps = 3/78 (3%)
Query: 113 LDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQL---E 169
L+ +E+R R +D + + +++ R Q+L E+ Q ++ E+E+K + +
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQ 1889
Query: 170 EERSRHKQLSSMLVLECK 187
+E RH+Q+ + E K
Sbjct: 1890 KEEQRHRQVGEIKSQEGK 1907
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 60.8 bits (146), Expect = 4e-09
Identities = 70/315 (22%), Positives = 140/315 (44%), Gaps = 44/315 (13%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ 146
+++ K +E L ++ A R ++ EE++++ Q A+ D+ T + + ERL ++
Sbjct: 567 LEEVKLKREERLRKVLQARERVEQM---KEEKKKQIEQKFAQIDEKTE--KAKEERLAEE 621
Query: 147 LEFEKSQVKKFEK---------EQKKLS-SQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
+K+ KK E+ E ++L Q EEE RH++L E ++ KAAE
Sbjct: 622 KAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE- 680
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
A L+ + E+E+ + E+E E++R Q + E+QL+E + REQ R + RE
Sbjct: 681 ---AKRLAEQREQERREQERREQE-RREQERREQERREQERQLAEQERRREQERLQAERE 736
Query: 257 -ENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLMSVFCQTE 315
+ R K L+ + E L++ +++ + + E+ + + +
Sbjct: 737 LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQ--------------------EEQ 776
Query: 316 SFPAERTHGSNIAKMTNTGLPGPATPAYSYAKTNGHCDPEIQTTR---ELTAGNNVENQV 372
A+ G++ A + PA +Y P+I +L + ++ +++
Sbjct: 777 EKKAKEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEA 836
Query: 373 PPREKSVALAQEKPV 387
PR+ A+ P+
Sbjct: 837 HPRKPIPTWARGTPL 851
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/246 (23%), Positives = 111/246 (45%), Gaps = 25/246 (10%)
Query: 19 EGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGE---KQPV 75
E +L+ + + + L+A+ R ++E K I + E KE+ E K+
Sbjct: 569 EVKLKREERLRKVLQARERVEQMKEEKKK-QIEQKFAQIDEKTEKAKEERLAEEKAKKKA 627
Query: 76 CTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYM 135
+ ++ KQ + + Q E RH++++ +EE Q + AE +
Sbjct: 628 AAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQ 687
Query: 136 LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQL-EEERSRHKQLSSMLVLECKKATNKAA 194
E+ER R ++ E E+ + ++ E+E+++ QL E+ER R ++ A
Sbjct: 688 REQER-REQERREQERREQERREQERREQERQLAEQERRREQE-------------RLQA 733
Query: 195 EEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLN 254
E + E +L+L+KE +L+ EL E+K+ + + E+QL E ++ + A +
Sbjct: 734 ERELQEREKALRLQKE-----QLQREL-EEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 787
Query: 255 REENRT 260
+ N T
Sbjct: 788 KALNVT 793
Score = 41.6 bits (96), Expect = 0.002
Identities = 40/169 (23%), Positives = 76/169 (44%), Gaps = 18/169 (10%)
Query: 136 LEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAE 195
+EKER+RL E+++ + +K ++ +LEE + + ++ VL+ ++ + E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREE-RLRKVLQARERVEQMKE 593
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQ------L 249
E +K ++ K + + K +EE AE K + A K++ E + R+Q L
Sbjct: 594 EKKK--QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAA---KKMEEVEARRKQEEEARRL 648
Query: 250 RAKLNREENR------TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK 292
R EE R K +EE E L+K + + Q + ++
Sbjct: 649 RWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQER 697
Score = 38.5 bits (88), Expect = 0.019
Identities = 24/97 (24%), Positives = 45/97 (46%), Gaps = 5/97 (5%)
Query: 207 LEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEE 266
+EKE+ R+ L + AE+ R + E ++L E ++RE+ K+ + R + +KEE
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 267 M-----ESLKKIVKDLEASHQHSSPNEQLKKPVTVSK 298
+ +I + E + + E+ KK K
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKK 631
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 60.5 bits (145), Expect = 5e-09
Identities = 70/335 (20%), Positives = 147/335 (43%), Gaps = 64/335 (19%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
+ L K + E L LE + ++ AL+ +H D+ E N+ L+++
Sbjct: 1164 VELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKE 1223
Query: 61 FETLKEKNDGEKQPVCTNPLSILKV---VMKQCKNMQERMLSQLAAAESRHRKVILDLEE 117
LK + D + +N +I K + K C+++++++ S+L E +++I DL
Sbjct: 1224 KSELKMETDD----LSSNAEAISKAKGNLEKMCRSLEDQV-SELKTKEEEQQRLINDLTA 1278
Query: 118 ERQR-------HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKK-------------- 156
+R R +++ E D + L + ++ TQQ+E K Q+++
Sbjct: 1279 QRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQS 1338
Query: 157 -----------FEKEQK----------KLSSQLEEERSRHKQLSSMLVLECKKATNKAAE 195
+E+EQ+ K +S++ + R++++ + E ++A K A+
Sbjct: 1339 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1398
Query: 196 EGQKAGE-------LSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ-------LSE 241
Q+A E LEK K R+ E+L + +R A ++K+ LSE
Sbjct: 1399 RLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSE 1458
Query: 242 FDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD 276
+ + E+ +A+L + +++L E+ +K + ++
Sbjct: 1459 WKQKYEETQAELEASQKESRSLSTELFKVKNVYEE 1493
Score = 55.8 bits (133), Expect = 1e-07
Identities = 76/312 (24%), Positives = 141/312 (45%), Gaps = 33/312 (10%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
+N+ +K +L LEG LE + L+ R + + + + D ++ D
Sbjct: 1020 VNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMD----MEND 1075
Query: 61 FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQ 120
+ L EK + +K+ +N +S K+ +Q +Q + ++ ++R ++ ++E ER
Sbjct: 1076 KQQLDEKLE-KKEFEISNLIS--KIEDEQAVEIQ--LQKKIKELQARIEELGEEIEAERA 1130
Query: 121 RHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV---KKFEKEQKKLSSQLEEERSRHKQ 177
A+ + D++ LE+ ERL + +QV KK E E +KL LEE +H+
Sbjct: 1131 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEA 1190
Query: 178 LSSMLVLECKKATNKAAEEGQKAGELSL---KLEKEKSRVSKLEEELAAERKRGLQTEAQ 234
+ + L KK + AE G++ L KLEKEKS + ++L++ + + +
Sbjct: 1191 MVAALR---KKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGN 1247
Query: 235 VEK-------QLSEFDIEREQ-------LRAKLNREENRTKTLKEEMESLKKIVKDLEAS 280
+EK Q+SE + E+ L A+ R + +++ +V L S
Sbjct: 1248 LEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRS 1307
Query: 281 HQHSSPN-EQLK 291
Q S+ E+LK
Sbjct: 1308 KQASTQQIEELK 1319
Score = 50.4 bits (119), Expect = 5e-06
Identities = 43/173 (24%), Positives = 91/173 (52%), Gaps = 19/173 (10%)
Query: 137 EKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
E E+E T + EF+K++ + + E K+ +LEE+ + + L L+ + + A+
Sbjct: 847 ETEKEMATMKEEFQKTKDELAKSEAKR--KELEEKMVTLLKEKNDLQLQVQSEADSLADA 904
Query: 197 GQKAGEL---SLKLE---KEKSRVSKLEEELAAE---RKRGLQTE-AQVEKQLSEFDIER 246
++ +L ++LE KE + ++ EEE+ AE +KR L+ E ++++K + + ++
Sbjct: 905 EERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTL 964
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIV-------KDLEASHQHSSPNEQLKK 292
++ + + EN+ K L EEM L + + K L+ +HQ + + Q ++
Sbjct: 965 AKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEE 1017
Score = 47.0 bits (110), Expect = 5e-05
Identities = 52/206 (25%), Positives = 99/206 (48%), Gaps = 29/206 (14%)
Query: 87 MKQCKNMQERMLSQLAAAESRHR----KVILDLEEERQRHAQDTAEGDDVTYMLEKERER 142
M K ++ +LA +E++ + K++ L+E+ Q +E D + + E
Sbjct: 852 MATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLA-----DAEE 906
Query: 143 LTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGE 202
+QL K Q+ E + K+++ + EEE +++++ L + +K ++ +E + +
Sbjct: 907 RCEQLIKNKIQL---EAKIKEVTERAEEE----EEINAELTAKKRKLEDECSELKKDIDD 959
Query: 203 LSL---KLEKEK----SRVSKLEEELAAERKRGL-QTEAQVEKQLSEFDIEREQLRAKLN 254
L L K+EKEK ++V L EE+A GL +T A++ K+ +Q L
Sbjct: 960 LELTLAKVEKEKHATENKVKNLTEEMA-----GLDETIAKLSKEKKALQETHQQTLDDLQ 1014
Query: 255 REENRTKTLKEEMESLKKIVKDLEAS 280
EE++ L + L++ V DLE S
Sbjct: 1015 AEEDKVNILTKAKTKLEQQVDDLEGS 1040
Score = 37.7 bits (86), Expect = 0.033
Identities = 40/200 (20%), Positives = 86/200 (43%), Gaps = 39/200 (19%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILD---LEEERQRHAQDTAEGDDVTYMLEKERERL 143
+ Q ++ E ++ + AE + +K I D + EE ++ +A + + LE+ + L
Sbjct: 1737 VSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDL 1796
Query: 144 TQQLEFE--------KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAE 195
+L+ K Q++K E ++L ++E E+ R N A
Sbjct: 1797 QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKR----------------NAEAV 1840
Query: 196 EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEK---QLSEFDIEREQLRAK 252
+G L K + RV +L + +RK L+ + V+K ++ + + E+ +
Sbjct: 1841 KG---------LRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQ 1891
Query: 253 LNREENRTKTLKEEMESLKK 272
N ++ + L+ E+E ++
Sbjct: 1892 SNANLSKFRKLQHELEEAEE 1911
Score = 37.4 bits (85), Expect = 0.043
Identities = 44/188 (23%), Positives = 79/188 (42%), Gaps = 25/188 (13%)
Query: 84 KVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAE------GDDVTYMLE 137
K + +E Q +A K L+ + +H D AE G LE
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819
Query: 138 KERERLTQQLEFEKSQ-------VKKFEKEQKKLSSQLEEERSRHKQLSSML-VLECK-K 188
L ++E E+ + ++K E+ K+L+ Q EE+R +L ++ L+ K K
Sbjct: 1820 ARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK 1879
Query: 189 ATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQ 248
+ + AEE ++ +L S+ KL+ EL +R E+QV K ++ +
Sbjct: 1880 SYKRQAEEAEEQSNANL------SKFRKLQHELEEAEERADIAESQVNK----LRVKSRE 1929
Query: 249 LRAKLNRE 256
+ K++ E
Sbjct: 1930 VHTKISAE 1937
Score = 32.3 bits (72), Expect = 1.4
Identities = 67/298 (22%), Positives = 129/298 (43%), Gaps = 36/298 (12%)
Query: 2 NLEKLSKPELLTLFSILEGELEARDLVIEALKAQHR--DTFIEERYGKYNISDP-LMALQ 58
+LEK +K L L ++E + AL + R D + E KY + L A Q
Sbjct: 1416 SLEK-TKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQ 1474
Query: 59 RDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEE 118
++ +L + K V L L+ + ++ KN+Q+ +S L + K I +LE+
Sbjct: 1475 KESRSLSTELFKVKN-VYEESLDQLETLRRENKNLQQE-ISDLTEQIAEGGKQIHELEKI 1532
Query: 119 RQRHAQDTAEG----DDVTYMLEKERERLTQ-QLEFE--KSQVKKFEKEQKKLSSQLEEE 171
+++ Q+ E ++ LE E ++ + QLE KS+V + E+ + QL+
Sbjct: 1533 KKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRN 1592
Query: 172 RSRHKQ-LSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERK--RG 228
+R + + S L E + + + + G+L+ ++E + + ++L E + +G
Sbjct: 1593 HTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLN-EMEIQLNHANRLAAESLRNYRNTQG 1651
Query: 229 LQTEAQ-------------------VEKQLSEFDIEREQLRAKLNREENRTKTLKEEM 267
+ E Q VE++ + E E+L A L + E K ++E+
Sbjct: 1652 ILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQEL 1709
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 60.1 bits (144), Expect = 6e-09
Identities = 61/226 (26%), Positives = 101/226 (44%), Gaps = 31/226 (13%)
Query: 91 KNMQERM--LSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ-- 146
KN+ E M L + A ++ +K L+E Q+ D +D L K + +L QQ
Sbjct: 980 KNLTEEMAGLDETIAKLTKEKKA---LQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVD 1036
Query: 147 -----LEFEKSQVKKFEKEQKKLSSQLE-------EERSRHKQLSSMLV---LECKKATN 191
LE EK E+ ++KL L+ + + +QL+ L E
Sbjct: 1037 DLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQG 1096
Query: 192 KAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRA 251
K +E A +L K+++ ++R+ +LEEE+ AER + A+ EKQ S+ E E++
Sbjct: 1097 KIEDEQALAIQLQKKIKELQARIEELEEEIEAER----ASRAKAEKQRSDLSRELEEISE 1152
Query: 252 KLNREENRTKTL----KEEMESLKKIVKDLEASH-QHSSPNEQLKK 292
+L T K+ +K+ +DLE S QH + L+K
Sbjct: 1153 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRK 1198
Score = 53.1 bits (126), Expect = 8e-07
Identities = 51/207 (24%), Positives = 94/207 (45%), Gaps = 16/207 (7%)
Query: 96 RMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV- 154
++ ++ ++R ++ ++E ER A+ + D++ LE+ ERL + +Q+
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE 1166
Query: 155 --KKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL---KLEK 209
KK E E +K+ LEE +H+ ++ L KK + AE G++ L KLEK
Sbjct: 1167 MNKKREAEFQKMRRDLEESTLQHEATAAALR---KKHADSVAELGEQIDSLQRVKQKLEK 1223
Query: 210 EKSRVSKLEEELAAERKRGLQTEAQVEK-------QLSEFDIEREQLRAKLNREENRTKT 262
EKS + +LA+ + + +A EK QLSE + E+ + +N +
Sbjct: 1224 EKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKAR 1283
Query: 263 LKEEMESLKKIVKDLEASHQHSSPNEQ 289
L E + + + +A S +Q
Sbjct: 1284 LHTESGEFSRQLDEKDAMVSQLSRGKQ 1310
Score = 47.8 bits (112), Expect = 3e-05
Identities = 54/208 (25%), Positives = 101/208 (48%), Gaps = 32/208 (15%)
Query: 88 KQCKNMQE---RMLSQLAAAESRHR----KVILDLEEERQRHAQDTAEGDDVTYMLEKER 140
K+ NM+E + +LA E++ + K++ ++E+ Q AE D + +
Sbjct: 851 KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALA-----DA 905
Query: 141 ERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKA 200
E QL K Q+ E + K+++ + E+E +++++ L + +K ++ +E +
Sbjct: 906 EERCDQLIKTKIQL---EAKIKEVTERAEDE----EEINAELTAKKRKLEDECSELKKDI 958
Query: 201 GELSL---KLEKEK----SRVSKLEEELAAERKRGL-QTEAQVEKQLSEFDIEREQLRAK 252
+L L K+EKEK ++V L EE+A GL +T A++ K+ +Q
Sbjct: 959 DDLELTLAKVEKEKHATENKVKNLTEEMA-----GLDETIAKLTKEKKALQEAHQQTLDD 1013
Query: 253 LNREENRTKTLKEEMESLKKIVKDLEAS 280
L EE++ TL + L++ V DLE S
Sbjct: 1014 LQMEEDKVNTLTKAKTKLEQQVDDLEGS 1041
Score = 47.8 bits (112), Expect = 3e-05
Identities = 66/338 (19%), Positives = 144/338 (42%), Gaps = 70/338 (20%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
+ + K + E + LE + AL+ +H D+ E + + + +LQR
Sbjct: 1165 IEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAE-------LGEQIDSLQRV 1217
Query: 61 FETL-KEKND--GEKQPVCTNPLSILKVVM---KQCKNMQERMLSQLAAAESRHRKVILD 114
+ L KEK++ E + +N ++ K K C+ ++++ LS++ E +++I +
Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQ-LSEIKTKEEEQQRLINE 1276
Query: 115 LEEERQR-------HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKK----------- 156
L ++ R ++ E D + L + ++ TQQ+E K Q+++
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHA 1336
Query: 157 --------------FEKEQK----------KLSSQLEEERSRHKQLSSMLVLECKKATNK 192
+E+EQ+ K +S++ + R++++ + E ++A K
Sbjct: 1337 LQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1396
Query: 193 AAEEGQKAGE-------LSLKLEKEKSRVSKLEEELAAERKRGL-------QTEAQVEKQ 238
A+ Q A E LEK K R+ E+L + +R + + +K
Sbjct: 1397 LAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKV 1456
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD 276
L+E+ + E+ +A+L + +++L E+ +K ++
Sbjct: 1457 LAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEE 1494
Score = 37.0 bits (84), Expect = 0.056
Identities = 42/196 (21%), Positives = 90/196 (45%), Gaps = 23/196 (11%)
Query: 83 LKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERER 142
L+ + Q + E ++ + AE + +K I D A++ + D + LE+ ++
Sbjct: 1734 LETDISQIQGEMEDIVQEARNAEEKAKKAITDAA----MMAEELKKEQDTSAHLERMKKN 1789
Query: 143 LTQQLEFEKSQVKKFEKEQKKLSS---QLEEERSRHKQLSSMLVLECKKATNKAAEEGQK 199
+ Q ++ Q++ E EQ L Q+++ +R ++L S + E ++ N A +G
Sbjct: 1790 MEQTVK--DLQLRLDEAEQLALKGGKKQIQKLEARVRELESEV--ESEQKHNVEAVKG-- 1843
Query: 200 AGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEK---QLSEFDIEREQLRAKLNRE 256
L K + RV +L + +RK L+ + V+K ++ + + E+ + N
Sbjct: 1844 -------LRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVN 1896
Query: 257 ENRTKTLKEEMESLKK 272
+ + L+ E+E K+
Sbjct: 1897 LAKFRKLQHELEEAKE 1912
Score = 36.2 bits (82), Expect = 0.095
Identities = 46/191 (24%), Positives = 85/191 (44%), Gaps = 32/191 (16%)
Query: 95 ERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV 154
ER + A + + R L E +Q++ + AE LE ++ ++ L E +V
Sbjct: 1437 ERSNAACIALDKKQRNFDKVLAEWKQKYEETQAE-------LEASQKE-SRSLSTELFKV 1488
Query: 155 KK-FEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGEL-----SLKLE 208
K +E+ L + E ++ +++S + T + AE G+ EL L E
Sbjct: 1489 KNAYEESLDHLETLKRENKNLQQEISDL--------TEQIAEGGKHIHELEKVKKQLDHE 1540
Query: 209 KEKSRVSKLEEELAAERKRGL---------QTEAQVEKQLSEFDIEREQL-RAKLNREEN 258
K + + S E E + E + G Q +++++++++E D E +QL R L E+
Sbjct: 1541 KSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVES 1600
Query: 259 RTKTLKEEMES 269
TL E+ S
Sbjct: 1601 MQSTLDAEIRS 1611
Score = 35.0 bits (79), Expect = 0.21
Identities = 53/243 (21%), Positives = 104/243 (42%), Gaps = 53/243 (21%)
Query: 62 ETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQR 121
E K KN E+ L L+ + ++ KN+Q+ +S L + K I +LE+ +++
Sbjct: 1484 ELFKVKNAYEES------LDHLETLKRENKNLQQE-ISDLTEQIAEGGKHIHELEKVKKQ 1536
Query: 122 HAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLE------EERSRH 175
+ +E L+ E LE E+ ++ + + E ++ S+++ +E
Sbjct: 1537 LDHEKSE-------LQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQ 1589
Query: 176 KQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL------AAERKRGL 229
+ + + V+E ++T A E + L +K +K + ++++E +L AAE R L
Sbjct: 1590 LKRNHLRVVESMQSTLDA-EIRSRNDALRIK-KKMEGDLNEMEIQLNHANRQAAEALRNL 1647
Query: 230 QTE-------------------------AQVEKQLSEFDIEREQLRAKLNREENRTKTLK 264
+ A VE++ + E E+LRA L R E K +
Sbjct: 1648 RNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAE 1707
Query: 265 EEM 267
+E+
Sbjct: 1708 QEL 1710
Score = 33.1 bits (74), Expect = 0.81
Identities = 55/231 (23%), Positives = 102/231 (44%), Gaps = 62/231 (26%)
Query: 7 SKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKE 66
+K +L T S ++GE+E D+V EA A+ + K I+D M E LK+
Sbjct: 1730 TKKKLETDISQIQGEME--DIVQEARNAEEK--------AKKAITDAAMMA----EELKK 1775
Query: 67 KNDGEKQPVCTNPLSILKVVMKQC-KNMQERM-----------LSQLAAAESRHRKVILD 114
+ D L +K M+Q K++Q R+ Q+ E+R R++ +
Sbjct: 1776 EQDTSAH------LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESE 1829
Query: 115 LEEERQRHAQDTAEG--------DDVTYMLEKERE---RLTQQLEFEKSQVKKFEKEQ-- 161
+E E Q+H + +G ++TY E++R+ RL ++ +++VK ++++
Sbjct: 1830 VESE-QKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQAEE 1888
Query: 162 ------------KKLSSQLEEERSR----HKQLSSMLVLECKKATNKAAEE 196
+KL +LEE + R Q++ + V + T +EE
Sbjct: 1889 AEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISEE 1939
Score = 29.6 bits (65), Expect = 8.9
Identities = 16/54 (29%), Positives = 30/54 (55%)
Query: 229 LQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
L A+ EK+++ E E+ + +L + E + K L+E+M +L + DL+ Q
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQ 896
>gi|33946313 ninein isoform 4 [Homo sapiens]
Length = 2096
Score = 59.7 bits (143), Expect = 8e-09
Identities = 61/259 (23%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ-CKNMQERMLSQLAAAESRHRKVILDL- 115
QR+ + +EK + E C S ++ + C+ + ER S L + E R+R+ + DL
Sbjct: 799 QRELQEGREKMETE----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 854
Query: 116 EEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRH 175
E++R+ +Q E D++T + +E L + L+ EK+ +E++ L +E +
Sbjct: 855 EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 914
Query: 176 KQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQ- 234
L+ + + N + + + L+L+ R + EE+ + Q +Q
Sbjct: 915 VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 974
Query: 235 VEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV 294
+E+ E D ER+++ +KL EN K E + ++ E S S E +
Sbjct: 975 LERLEMEHDQERQEMMSKLLAMENIHKATCETADR-ERAEMSTEISRLQSKIKEMQQ--- 1030
Query: 295 TVSKGTATEPLMLMSVFCQ 313
AT PL ++ CQ
Sbjct: 1031 ------ATSPLSMLQSGCQ 1043
Score = 47.0 bits (110), Expect = 5e-05
Identities = 56/226 (24%), Positives = 97/226 (42%), Gaps = 46/226 (20%)
Query: 115 LEEERQRHAQDTAEGDDVTYMLEK----------------------ERERLTQQLEFEKS 152
LE E +A+ AE +++T L++ + ERLTQ +
Sbjct: 489 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 548
Query: 153 QVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKS 212
Q + + + +L S+LEE R++ + L L L+ + A G E L E+
Sbjct: 549 QCRVLQDQVDELQSELEEYRAQGRVL--RLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 606
Query: 213 RVSKLEEELAAERKR----------GLQTEAQV---EKQLSEFDIEREQLRAKL-NREEN 258
+E EL E+ + L+ E +V EKQL E + ++ + + R EN
Sbjct: 607 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 666
Query: 259 RTKTLKEEMESLKKIVKDL--------EASHQHSSPNEQLKKPVTV 296
T TL++++ LK + +L EA H+ + +E+ KK + V
Sbjct: 667 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV 712
Score = 44.3 bits (103), Expect = 3e-04
Identities = 60/288 (20%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 41 IEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQ 100
+E RY + + D L QR+ ++ E E C +LK +K+ K + +
Sbjct: 842 LEGRY-RQELKD-LQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 899
Query: 101 LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE 160
E +++ + + ERQ+ QD +D+ + E ++ L+ Q+ KS K+ +E
Sbjct: 900 REMLEKTYKEHLNSMVVERQQLLQDL---EDLRNVSETQQSLLSDQILELKSSHKRELRE 956
Query: 161 QKKLSSQ----------------LEEERSRHKQLSSMLVLE-CKKATNKAAEEGQKAGEL 203
++++ Q +E ++ R + +S +L +E KAT + A+ ++ E+
Sbjct: 957 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD--RERAEM 1014
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR-----EEN 258
S ++ + +S++ ++++ A LQ+ QV + E ++E + + L + EEN
Sbjct: 1015 STEISRLQSKIKEMQQ--ATSPLSMLQSGCQV---IGEEEVEGDGALSLLQQGEQLLEEN 1069
Query: 259 RTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK--PVTVSKGTATEP 304
L + + + ++++ + + S ++L+K P V EP
Sbjct: 1070 GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEP 1117
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/190 (24%), Positives = 96/190 (50%), Gaps = 21/190 (11%)
Query: 105 ESRHRKVI-LDLE-EERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQK 162
E HR + L LE E++ RH + D+ +K +E + Q+ E E ++K + K
Sbjct: 622 EQHHRDICCLRLELEDKVRHYEKQL--DETVVSCKKAQENMKQRHENETHTLEKQISDLK 679
Query: 163 KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELA 222
++L+ + + K+ +AT + EE + +L +KLE+EK+ L+E+L
Sbjct: 680 NEIAELQGQAAVLKEAHH-------EATCRHEEEKK---QLQVKLEEEKTH---LQEKLR 726
Query: 223 AERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + ++ +A++ + + F+ ERE L++ EE + + L +E+E + + +
Sbjct: 727 LQHE--MELKARLTQAQASFEREREGLQSSAWTEE-KVRGLTQELEQFHQ-EQLTSLVEK 782
Query: 283 HSSPNEQLKK 292
H+ E+L+K
Sbjct: 783 HTLEKEELRK 792
Score = 41.2 bits (95), Expect = 0.003
Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 42/294 (14%)
Query: 19 EGELEA--RDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKND------- 69
E EL+A DL I + Q + + RY + L+ + TL E++
Sbjct: 1494 EEELKAMMHDLQITCSEMQQKVELL--RYESEKLQQENSILRNEITTLNEEDSISNLKLG 1551
Query: 70 --GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
Q +K + M E + Q++ + +++++ L+ E Q+++Q+
Sbjct: 1552 TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1611
Query: 128 EGDDVTYMLEKERERLTQQL---EFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV- 183
+ L++ +RLT+ L E E E+EQ+K + L+EE R K SS LV
Sbjct: 1612 K-------LQELNQRLTEMLCQKEKEPGNSALEEREQEKFN--LKEELERCKVQSSTLVS 1662
Query: 184 -LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
LE + + K + LK E EK + +L+ +++ + EK L E
Sbjct: 1663 SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1722
Query: 243 DIEREQLR------AKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
+ E+L AK + E+R T+K+E +S + HQ +S QL
Sbjct: 1723 EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE---------HQSASLKSQL 1767
Score = 40.4 bits (93), Expect = 0.005
Identities = 49/205 (23%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE--- 150
QE++ S + ++ +L E+ QR Q+ E +E E R T Q+E +
Sbjct: 773 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE------KMETECNRRTSQIEAQFQS 826
Query: 151 -------------KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+S ++ +E K L Q EE+S+ + L EC +A E
Sbjct: 827 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE-- 884
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE 257
+LK EK S V E E+ E ++ L+ +ER+QL L
Sbjct: 885 ------TLKREKTTSLVLTQEREM---------LEKTYKEHLNSMVVERQQLLQDLEDLR 929
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQ 282
N ++T + L + +L++SH+
Sbjct: 930 NVSET---QQSLLSDQILELKSSHK 951
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/287 (20%), Positives = 119/287 (41%), Gaps = 52/287 (18%)
Query: 26 DLVIEALKAQHRDTF------IEERYGKYN--ISDPLMALQRDFETLKEKNDGEKQPVCT 77
+LVIE +K QH +E++ Y + + +++ ++ E +K++++ E
Sbjct: 614 ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT--- 670
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
L+ + KN + Q A + H E RH E
Sbjct: 671 -----LEKQISDLKNEIAELQGQAAVLKEAHH-------EATCRH--------------E 704
Query: 138 KERERLTQQLEFEKSQVK-------KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
+E+++L +LE EK+ ++ + E + + +Q ER R SS E +
Sbjct: 705 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 764
Query: 191 NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR 250
+ E+ + +L+ +EK +L +EL + +R LQ EK +E + Q+
Sbjct: 765 TQELEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGR--EKMETECNRRTSQIE 821
Query: 251 AKLNRE-ENRTKTLKEEMESL----KKIVKDLEASHQHSSPNEQLKK 292
A+ + + T+ + ++SL ++ +KDL+ + + +K
Sbjct: 822 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 868
Score = 37.0 bits (84), Expect = 0.056
Identities = 36/191 (18%), Positives = 86/191 (45%), Gaps = 9/191 (4%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFE-----KEQ 161
+H+ I +LE E+ + + T + + +L K+++ L+ + E+ + + E
Sbjct: 1452 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEM 1511
Query: 162 KKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL 221
++ L E + +Q +S+L E + + K G L+ E+ + +++E
Sbjct: 1512 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1571
Query: 222 AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASH 281
AA +K ++KQ+SE I+ +QL + + +E+++ L + + ++
Sbjct: 1572 AAVQKM----VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1627
Query: 282 QHSSPNEQLKK 292
+ N L++
Sbjct: 1628 EKEPGNSALEE 1638
Score = 32.0 bits (71), Expect = 1.8
Identities = 72/349 (20%), Positives = 143/349 (40%), Gaps = 53/349 (15%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVI------EALKAQHRDTF-IEERYGKYNISDPLMA 56
+ L ++L L S + EL R+ V+ E L +Q + +E + + L+A
Sbjct: 936 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 995
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLE 116
++ + E D E+ + T + + + K MQ+ S L+ +S + VI + E
Sbjct: 996 MENIHKATCETADRERAEMSTE----ISRLQSKIKEMQQAT-SPLSMLQSGCQ-VIGEEE 1049
Query: 117 EER-------QRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKL----- 164
E Q+ Q E DV L++ E+ ++ +++ + ++ +KL
Sbjct: 1050 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1109
Query: 165 -SSQLEE-----------------ERSRHKQLSSMLV------LECKKATNKAAEEGQKA 200
SS L+E +++R KQ+ + LE + + +
Sbjct: 1110 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1169
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTEA-QVEKQLSEFDIEREQLRAKLNREENR 259
+K+E+ ++ V E +E R TE+ +++ Q+S+ + L A +R +
Sbjct: 1170 QRQEVKIEESEASVEGFSELENSEETR---TESWELKNQISQLQEQLMMLCADCDRASEK 1226
Query: 260 TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLM 308
+ L ++ LKK +K LE + S + L + V+ E L +M
Sbjct: 1227 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1275
Score = 30.8 bits (68), Expect = 4.0
Identities = 33/152 (21%), Positives = 70/152 (46%), Gaps = 20/152 (13%)
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE-----ERSRHKQLSSM---- 181
++ ++LE+ +++ ++ E +S + K EK + ++S++++ ER L +
Sbjct: 374 EIRHLLERV-DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 432
Query: 182 --LVLECKKATNKAAEEG-QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ 238
+ K K E+ Q+AG+ L+LE+E + E + L+ +++E +
Sbjct: 433 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 492
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESL 270
L E KL EN T L+ +E++
Sbjct: 493 LLE-------NAEKLAEYENLTNKLQRNLENV 517
>gi|33946321 ninein isoform 5 [Homo sapiens]
Length = 2090
Score = 59.7 bits (143), Expect = 8e-09
Identities = 61/259 (23%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ-CKNMQERMLSQLAAAESRHRKVILDL- 115
QR+ + +EK + E C S ++ + C+ + ER S L + E R+R+ + DL
Sbjct: 793 QRELQEGREKMETE----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
Query: 116 EEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRH 175
E++R+ +Q E D++T + +E L + L+ EK+ +E++ L +E +
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 908
Query: 176 KQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQ- 234
L+ + + N + + + L+L+ R + EE+ + Q +Q
Sbjct: 909 VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 968
Query: 235 VEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV 294
+E+ E D ER+++ +KL EN K E + ++ E S S E +
Sbjct: 969 LERLEMEHDQERQEMMSKLLAMENIHKATCETADR-ERAEMSTEISRLQSKIKEMQQ--- 1024
Query: 295 TVSKGTATEPLMLMSVFCQ 313
AT PL ++ CQ
Sbjct: 1025 ------ATSPLSMLQSGCQ 1037
Score = 47.0 bits (110), Expect = 5e-05
Identities = 56/226 (24%), Positives = 97/226 (42%), Gaps = 46/226 (20%)
Query: 115 LEEERQRHAQDTAEGDDVTYMLEK----------------------ERERLTQQLEFEKS 152
LE E +A+ AE +++T L++ + ERLTQ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 542
Query: 153 QVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKS 212
Q + + + +L S+LEE R++ + L L L+ + A G E L E+
Sbjct: 543 QCRVLQDQVDELQSELEEYRAQGRVL--RLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
Query: 213 RVSKLEEELAAERKR----------GLQTEAQV---EKQLSEFDIEREQLRAKL-NREEN 258
+E EL E+ + L+ E +V EKQL E + ++ + + R EN
Sbjct: 601 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 259 RTKTLKEEMESLKKIVKDL--------EASHQHSSPNEQLKKPVTV 296
T TL++++ LK + +L EA H+ + +E+ KK + V
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV 706
Score = 44.3 bits (103), Expect = 3e-04
Identities = 60/288 (20%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 41 IEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQ 100
+E RY + + D L QR+ ++ E E C +LK +K+ K + +
Sbjct: 836 LEGRY-RQELKD-LQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
Query: 101 LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE 160
E +++ + + ERQ+ QD +D+ + E ++ L+ Q+ KS K+ +E
Sbjct: 894 REMLEKTYKEHLNSMVVERQQLLQDL---EDLRNVSETQQSLLSDQILELKSSHKRELRE 950
Query: 161 QKKLSSQ----------------LEEERSRHKQLSSMLVLE-CKKATNKAAEEGQKAGEL 203
++++ Q +E ++ R + +S +L +E KAT + A+ ++ E+
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD--RERAEM 1008
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR-----EEN 258
S ++ + +S++ ++++ A LQ+ QV + E ++E + + L + EEN
Sbjct: 1009 STEISRLQSKIKEMQQ--ATSPLSMLQSGCQV---IGEEEVEGDGALSLLQQGEQLLEEN 1063
Query: 259 RTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK--PVTVSKGTATEP 304
L + + + ++++ + + S ++L+K P V EP
Sbjct: 1064 GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEP 1111
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/190 (24%), Positives = 96/190 (50%), Gaps = 21/190 (11%)
Query: 105 ESRHRKVI-LDLE-EERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQK 162
E HR + L LE E++ RH + D+ +K +E + Q+ E E ++K + K
Sbjct: 616 EQHHRDICCLRLELEDKVRHYEKQL--DETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
Query: 163 KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELA 222
++L+ + + K+ +AT + EE + +L +KLE+EK+ L+E+L
Sbjct: 674 NEIAELQGQAAVLKEAHH-------EATCRHEEEKK---QLQVKLEEEKTH---LQEKLR 720
Query: 223 AERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + ++ +A++ + + F+ ERE L++ EE + + L +E+E + + +
Sbjct: 721 LQHE--MELKARLTQAQASFEREREGLQSSAWTEE-KVRGLTQELEQFHQ-EQLTSLVEK 776
Query: 283 HSSPNEQLKK 292
H+ E+L+K
Sbjct: 777 HTLEKEELRK 786
Score = 41.2 bits (95), Expect = 0.003
Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 42/294 (14%)
Query: 19 EGELEA--RDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKND------- 69
E EL+A DL I + Q + + RY + L+ + TL E++
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELL--RYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
Query: 70 --GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
Q +K + M E + Q++ + +++++ L+ E Q+++Q+
Sbjct: 1546 TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1605
Query: 128 EGDDVTYMLEKERERLTQQL---EFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV- 183
+ L++ +RLT+ L E E E+EQ+K + L+EE R K SS LV
Sbjct: 1606 K-------LQELNQRLTEMLCQKEKEPGNSALEEREQEKFN--LKEELERCKVQSSTLVS 1656
Query: 184 -LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
LE + + K + LK E EK + +L+ +++ + EK L E
Sbjct: 1657 SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 243 DIEREQLR------AKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
+ E+L AK + E+R T+K+E +S + HQ +S QL
Sbjct: 1717 EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE---------HQSASLKSQL 1761
Score = 40.4 bits (93), Expect = 0.005
Identities = 49/205 (23%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE--- 150
QE++ S + ++ +L E+ QR Q+ E +E E R T Q+E +
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE------KMETECNRRTSQIEAQFQS 820
Query: 151 -------------KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+S ++ +E K L Q EE+S+ + L EC +A E
Sbjct: 821 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE-- 878
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE 257
+LK EK S V E E+ E ++ L+ +ER+QL L
Sbjct: 879 ------TLKREKTTSLVLTQEREM---------LEKTYKEHLNSMVVERQQLLQDLEDLR 923
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQ 282
N ++T + L + +L++SH+
Sbjct: 924 NVSET---QQSLLSDQILELKSSHK 945
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/287 (20%), Positives = 119/287 (41%), Gaps = 52/287 (18%)
Query: 26 DLVIEALKAQHRDTF------IEERYGKYN--ISDPLMALQRDFETLKEKNDGEKQPVCT 77
+LVIE +K QH +E++ Y + + +++ ++ E +K++++ E
Sbjct: 608 ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT--- 664
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
L+ + KN + Q A + H E RH E
Sbjct: 665 -----LEKQISDLKNEIAELQGQAAVLKEAHH-------EATCRH--------------E 698
Query: 138 KERERLTQQLEFEKSQVK-------KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
+E+++L +LE EK+ ++ + E + + +Q ER R SS E +
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
Query: 191 NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR 250
+ E+ + +L+ +EK +L +EL + +R LQ EK +E + Q+
Sbjct: 759 TQELEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGR--EKMETECNRRTSQIE 815
Query: 251 AKLNRE-ENRTKTLKEEMESL----KKIVKDLEASHQHSSPNEQLKK 292
A+ + + T+ + ++SL ++ +KDL+ + + +K
Sbjct: 816 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 862
Score = 37.0 bits (84), Expect = 0.056
Identities = 36/191 (18%), Positives = 86/191 (45%), Gaps = 9/191 (4%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFE-----KEQ 161
+H+ I +LE E+ + + T + + +L K+++ L+ + E+ + + E
Sbjct: 1446 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEM 1505
Query: 162 KKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL 221
++ L E + +Q +S+L E + + K G L+ E+ + +++E
Sbjct: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565
Query: 222 AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASH 281
AA +K ++KQ+SE I+ +QL + + +E+++ L + + ++
Sbjct: 1566 AAVQKM----VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
Query: 282 QHSSPNEQLKK 292
+ N L++
Sbjct: 1622 EKEPGNSALEE 1632
Score = 32.0 bits (71), Expect = 1.8
Identities = 72/349 (20%), Positives = 143/349 (40%), Gaps = 53/349 (15%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVI------EALKAQHRDTF-IEERYGKYNISDPLMA 56
+ L ++L L S + EL R+ V+ E L +Q + +E + + L+A
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLE 116
++ + E D E+ + T + + + K MQ+ S L+ +S + VI + E
Sbjct: 990 MENIHKATCETADRERAEMSTE----ISRLQSKIKEMQQAT-SPLSMLQSGCQ-VIGEEE 1043
Query: 117 EER-------QRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKL----- 164
E Q+ Q E DV L++ E+ ++ +++ + ++ +KL
Sbjct: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
Query: 165 -SSQLEE-----------------ERSRHKQLSSMLV------LECKKATNKAAEEGQKA 200
SS L+E +++R KQ+ + LE + + +
Sbjct: 1104 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTEA-QVEKQLSEFDIEREQLRAKLNREENR 259
+K+E+ ++ V E +E R TE+ +++ Q+S+ + L A +R +
Sbjct: 1164 QRQEVKIEESEASVEGFSELENSEETR---TESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 260 TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLM 308
+ L ++ LKK +K LE + S + L + V+ E L +M
Sbjct: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
Score = 30.8 bits (68), Expect = 4.0
Identities = 33/152 (21%), Positives = 70/152 (46%), Gaps = 20/152 (13%)
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE-----ERSRHKQLSSM---- 181
++ ++LE+ +++ ++ E +S + K EK + ++S++++ ER L +
Sbjct: 368 EIRHLLERV-DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 426
Query: 182 --LVLECKKATNKAAEEG-QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ 238
+ K K E+ Q+AG+ L+LE+E + E + L+ +++E +
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESL 270
L E KL EN T L+ +E++
Sbjct: 487 LLE-------NAEKLAEYENLTNKLQRNLENV 511
>gi|148536871 ninein isoform 1 [Homo sapiens]
Length = 2046
Score = 59.7 bits (143), Expect = 8e-09
Identities = 61/259 (23%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ-CKNMQERMLSQLAAAESRHRKVILDL- 115
QR+ + +EK + E C S ++ + C+ + ER S L + E R+R+ + DL
Sbjct: 793 QRELQEGREKMETE----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
Query: 116 EEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRH 175
E++R+ +Q E D++T + +E L + L+ EK+ +E++ L +E +
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 908
Query: 176 KQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQ- 234
L+ + + N + + + L+L+ R + EE+ + Q +Q
Sbjct: 909 VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 968
Query: 235 VEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV 294
+E+ E D ER+++ +KL EN K E + ++ E S S E +
Sbjct: 969 LERLEMEHDQERQEMMSKLLAMENIHKATCETADR-ERAEMSTEISRLQSKIKEMQQ--- 1024
Query: 295 TVSKGTATEPLMLMSVFCQ 313
AT PL ++ CQ
Sbjct: 1025 ------ATSPLSMLQSGCQ 1037
Score = 47.0 bits (110), Expect = 5e-05
Identities = 56/226 (24%), Positives = 97/226 (42%), Gaps = 46/226 (20%)
Query: 115 LEEERQRHAQDTAEGDDVTYMLEK----------------------ERERLTQQLEFEKS 152
LE E +A+ AE +++T L++ + ERLTQ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 542
Query: 153 QVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKS 212
Q + + + +L S+LEE R++ + L L L+ + A G E L E+
Sbjct: 543 QCRVLQDQVDELQSELEEYRAQGRVL--RLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
Query: 213 RVSKLEEELAAERKR----------GLQTEAQV---EKQLSEFDIEREQLRAKL-NREEN 258
+E EL E+ + L+ E +V EKQL E + ++ + + R EN
Sbjct: 601 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 259 RTKTLKEEMESLKKIVKDL--------EASHQHSSPNEQLKKPVTV 296
T TL++++ LK + +L EA H+ + +E+ KK + V
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV 706
Score = 44.3 bits (103), Expect = 3e-04
Identities = 60/288 (20%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 41 IEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQ 100
+E RY + + D L QR+ ++ E E C +LK +K+ K + +
Sbjct: 836 LEGRY-RQELKD-LQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
Query: 101 LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE 160
E +++ + + ERQ+ QD +D+ + E ++ L+ Q+ KS K+ +E
Sbjct: 894 REMLEKTYKEHLNSMVVERQQLLQDL---EDLRNVSETQQSLLSDQILELKSSHKRELRE 950
Query: 161 QKKLSSQ----------------LEEERSRHKQLSSMLVLE-CKKATNKAAEEGQKAGEL 203
++++ Q +E ++ R + +S +L +E KAT + A+ ++ E+
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD--RERAEM 1008
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR-----EEN 258
S ++ + +S++ ++++ A LQ+ QV + E ++E + + L + EEN
Sbjct: 1009 STEISRLQSKIKEMQQ--ATSPLSMLQSGCQV---IGEEEVEGDGALSLLQQGEQLLEEN 1063
Query: 259 RTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK--PVTVSKGTATEP 304
L + + + ++++ + + S ++L+K P V EP
Sbjct: 1064 GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEP 1111
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/190 (24%), Positives = 96/190 (50%), Gaps = 21/190 (11%)
Query: 105 ESRHRKVI-LDLE-EERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQK 162
E HR + L LE E++ RH + D+ +K +E + Q+ E E ++K + K
Sbjct: 616 EQHHRDICCLRLELEDKVRHYEKQL--DETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
Query: 163 KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELA 222
++L+ + + K+ +AT + EE + +L +KLE+EK+ L+E+L
Sbjct: 674 NEIAELQGQAAVLKEAHH-------EATCRHEEEKK---QLQVKLEEEKTH---LQEKLR 720
Query: 223 AERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + ++ +A++ + + F+ ERE L++ EE + + L +E+E + + +
Sbjct: 721 LQHE--MELKARLTQAQASFEREREGLQSSAWTEE-KVRGLTQELEQFHQ-EQLTSLVEK 776
Query: 283 HSSPNEQLKK 292
H+ E+L+K
Sbjct: 777 HTLEKEELRK 786
Score = 41.2 bits (95), Expect = 0.003
Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 42/294 (14%)
Query: 19 EGELEA--RDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKND------- 69
E EL+A DL I + Q + + RY + L+ + TL E++
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELL--RYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
Query: 70 --GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
Q +K + M E + Q++ + +++++ L+ E Q+++Q+
Sbjct: 1546 TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1605
Query: 128 EGDDVTYMLEKERERLTQQL---EFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV- 183
+ L++ +RLT+ L E E E+EQ+K + L+EE R K SS LV
Sbjct: 1606 K-------LQELNQRLTEMLCQKEKEPGNSALEEREQEKFN--LKEELERCKVQSSTLVS 1656
Query: 184 -LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
LE + + K + LK E EK + +L+ +++ + EK L E
Sbjct: 1657 SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 243 DIEREQLR------AKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
+ E+L AK + E+R T+K+E +S + HQ +S QL
Sbjct: 1717 EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE---------HQSASLKSQL 1761
Score = 40.4 bits (93), Expect = 0.005
Identities = 49/205 (23%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE--- 150
QE++ S + ++ +L E+ QR Q+ E +E E R T Q+E +
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE------KMETECNRRTSQIEAQFQS 820
Query: 151 -------------KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+S ++ +E K L Q EE+S+ + L EC +A E
Sbjct: 821 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE-- 878
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE 257
+LK EK S V E E+ E ++ L+ +ER+QL L
Sbjct: 879 ------TLKREKTTSLVLTQEREM---------LEKTYKEHLNSMVVERQQLLQDLEDLR 923
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQ 282
N ++T + L + +L++SH+
Sbjct: 924 NVSET---QQSLLSDQILELKSSHK 945
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/287 (20%), Positives = 119/287 (41%), Gaps = 52/287 (18%)
Query: 26 DLVIEALKAQHRDTF------IEERYGKYN--ISDPLMALQRDFETLKEKNDGEKQPVCT 77
+LVIE +K QH +E++ Y + + +++ ++ E +K++++ E
Sbjct: 608 ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT--- 664
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
L+ + KN + Q A + H E RH E
Sbjct: 665 -----LEKQISDLKNEIAELQGQAAVLKEAHH-------EATCRH--------------E 698
Query: 138 KERERLTQQLEFEKSQVK-------KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
+E+++L +LE EK+ ++ + E + + +Q ER R SS E +
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
Query: 191 NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR 250
+ E+ + +L+ +EK +L +EL + +R LQ EK +E + Q+
Sbjct: 759 TQELEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGR--EKMETECNRRTSQIE 815
Query: 251 AKLNRE-ENRTKTLKEEMESL----KKIVKDLEASHQHSSPNEQLKK 292
A+ + + T+ + ++SL ++ +KDL+ + + +K
Sbjct: 816 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 862
Score = 37.0 bits (84), Expect = 0.056
Identities = 36/191 (18%), Positives = 86/191 (45%), Gaps = 9/191 (4%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFE-----KEQ 161
+H+ I +LE E+ + + T + + +L K+++ L+ + E+ + + E
Sbjct: 1446 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEM 1505
Query: 162 KKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL 221
++ L E + +Q +S+L E + + K G L+ E+ + +++E
Sbjct: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565
Query: 222 AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASH 281
AA +K ++KQ+SE I+ +QL + + +E+++ L + + ++
Sbjct: 1566 AAVQKM----VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
Query: 282 QHSSPNEQLKK 292
+ N L++
Sbjct: 1622 EKEPGNSALEE 1632
Score = 32.0 bits (71), Expect = 1.8
Identities = 72/349 (20%), Positives = 143/349 (40%), Gaps = 53/349 (15%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVI------EALKAQHRDTF-IEERYGKYNISDPLMA 56
+ L ++L L S + EL R+ V+ E L +Q + +E + + L+A
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLE 116
++ + E D E+ + T + + + K MQ+ S L+ +S + VI + E
Sbjct: 990 MENIHKATCETADRERAEMSTE----ISRLQSKIKEMQQAT-SPLSMLQSGCQ-VIGEEE 1043
Query: 117 EER-------QRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKL----- 164
E Q+ Q E DV L++ E+ ++ +++ + ++ +KL
Sbjct: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
Query: 165 -SSQLEE-----------------ERSRHKQLSSMLV------LECKKATNKAAEEGQKA 200
SS L+E +++R KQ+ + LE + + +
Sbjct: 1104 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTEA-QVEKQLSEFDIEREQLRAKLNREENR 259
+K+E+ ++ V E +E R TE+ +++ Q+S+ + L A +R +
Sbjct: 1164 QRQEVKIEESEASVEGFSELENSEETR---TESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 260 TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLM 308
+ L ++ LKK +K LE + S + L + V+ E L +M
Sbjct: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
Score = 30.8 bits (68), Expect = 4.0
Identities = 33/152 (21%), Positives = 70/152 (46%), Gaps = 20/152 (13%)
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE-----ERSRHKQLSSM---- 181
++ ++LE+ +++ ++ E +S + K EK + ++S++++ ER L +
Sbjct: 368 EIRHLLERV-DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 426
Query: 182 --LVLECKKATNKAAEEG-QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ 238
+ K K E+ Q+AG+ L+LE+E + E + L+ +++E +
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESL 270
L E KL EN T L+ +E++
Sbjct: 487 LLE-------NAEKLAEYENLTNKLQRNLENV 511
>gi|148536869 ninein isoform 2 [Homo sapiens]
Length = 2133
Score = 59.7 bits (143), Expect = 8e-09
Identities = 61/259 (23%), Positives = 114/259 (44%), Gaps = 17/259 (6%)
Query: 58 QRDFETLKEKNDGEKQPVCTNPLSILKVVMKQ-CKNMQERMLSQLAAAESRHRKVILDL- 115
QR+ + +EK + E C S ++ + C+ + ER S L + E R+R+ + DL
Sbjct: 793 QRELQEGREKMETE----CNRRTSQIEAQFQSDCQKVTERCESALQSLEGRYRQELKDLQ 848
Query: 116 EEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRH 175
E++R+ +Q E D++T + +E L + L+ EK+ +E++ L +E +
Sbjct: 849 EQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQEREMLEKTYKEHLNSM 908
Query: 176 KQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQ- 234
L+ + + N + + + L+L+ R + EE+ + Q +Q
Sbjct: 909 VVERQQLLQDLEDLRNVSETQQSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQR 968
Query: 235 VEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPV 294
+E+ E D ER+++ +KL EN K E + ++ E S S E +
Sbjct: 969 LERLEMEHDQERQEMMSKLLAMENIHKATCETADR-ERAEMSTEISRLQSKIKEMQQ--- 1024
Query: 295 TVSKGTATEPLMLMSVFCQ 313
AT PL ++ CQ
Sbjct: 1025 ------ATSPLSMLQSGCQ 1037
Score = 47.0 bits (110), Expect = 5e-05
Identities = 56/226 (24%), Positives = 97/226 (42%), Gaps = 46/226 (20%)
Query: 115 LEEERQRHAQDTAEGDDVTYMLEK----------------------ERERLTQQLEFEKS 152
LE E +A+ AE +++T L++ + ERLTQ +
Sbjct: 483 LENELLENAEKLAEYENLTNKLQRNLENVLAEKFGDLDPSSAEFFLQEERLTQMRNEYER 542
Query: 153 QVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKS 212
Q + + + +L S+LEE R++ + L L L+ + A G E L E+
Sbjct: 543 QCRVLQDQVDELQSELEEYRAQGRVL--RLPLKNSPSEEVEANSGGIEPEHGLGSEECNP 600
Query: 213 RVSKLEEELAAERKR----------GLQTEAQV---EKQLSEFDIEREQLRAKL-NREEN 258
+E EL E+ + L+ E +V EKQL E + ++ + + R EN
Sbjct: 601 LNMSIEAELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHEN 660
Query: 259 RTKTLKEEMESLKKIVKDL--------EASHQHSSPNEQLKKPVTV 296
T TL++++ LK + +L EA H+ + +E+ KK + V
Sbjct: 661 ETHTLEKQISDLKNEIAELQGQAAVLKEAHHEATCRHEEEKKQLQV 706
Score = 44.3 bits (103), Expect = 3e-04
Identities = 60/288 (20%), Positives = 131/288 (45%), Gaps = 36/288 (12%)
Query: 41 IEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQ 100
+E RY + + D L QR+ ++ E E C +LK +K+ K + +
Sbjct: 836 LEGRY-RQELKD-LQEQQREEKSQWEFEKDELTQECAEAQELLKETLKREKTTSLVLTQE 893
Query: 101 LAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKE 160
E +++ + + ERQ+ QD +D+ + E ++ L+ Q+ KS K+ +E
Sbjct: 894 REMLEKTYKEHLNSMVVERQQLLQDL---EDLRNVSETQQSLLSDQILELKSSHKRELRE 950
Query: 161 QKKLSSQ----------------LEEERSRHKQLSSMLVLE-CKKATNKAAEEGQKAGEL 203
++++ Q +E ++ R + +S +L +E KAT + A+ ++ E+
Sbjct: 951 REEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLAMENIHKATCETAD--RERAEM 1008
Query: 204 SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR-----EEN 258
S ++ + +S++ ++++ A LQ+ QV + E ++E + + L + EEN
Sbjct: 1009 STEISRLQSKIKEMQQ--ATSPLSMLQSGCQV---IGEEEVEGDGALSLLQQGEQLLEEN 1063
Query: 259 RTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKK--PVTVSKGTATEP 304
L + + + ++++ + + S ++L+K P V EP
Sbjct: 1064 GDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLVMSSCLDEP 1111
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/190 (24%), Positives = 96/190 (50%), Gaps = 21/190 (11%)
Query: 105 ESRHRKVI-LDLE-EERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQK 162
E HR + L LE E++ RH + D+ +K +E + Q+ E E ++K + K
Sbjct: 616 EQHHRDICCLRLELEDKVRHYEKQL--DETVVSCKKAQENMKQRHENETHTLEKQISDLK 673
Query: 163 KLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELA 222
++L+ + + K+ +AT + EE + +L +KLE+EK+ L+E+L
Sbjct: 674 NEIAELQGQAAVLKEAHH-------EATCRHEEEKK---QLQVKLEEEKTH---LQEKLR 720
Query: 223 AERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + ++ +A++ + + F+ ERE L++ EE + + L +E+E + + +
Sbjct: 721 LQHE--MELKARLTQAQASFEREREGLQSSAWTEE-KVRGLTQELEQFHQ-EQLTSLVEK 776
Query: 283 HSSPNEQLKK 292
H+ E+L+K
Sbjct: 777 HTLEKEELRK 786
Score = 41.2 bits (95), Expect = 0.003
Identities = 71/294 (24%), Positives = 124/294 (42%), Gaps = 42/294 (14%)
Query: 19 EGELEA--RDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKND------- 69
E EL+A DL I + Q + + RY + L+ + TL E++
Sbjct: 1488 EEELKAMMHDLQITCSEMQQKVELL--RYESEKLQQENSILRNEITTLNEEDSISNLKLG 1545
Query: 70 --GEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
Q +K + M E + Q++ + +++++ L+ E Q+++Q+
Sbjct: 1546 TLNGSQEEMWQKTETVKQENAAVQKMVENLKKQISELKIKNQQLDLENTELSQKNSQNQE 1605
Query: 128 EGDDVTYMLEKERERLTQQL---EFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLV- 183
+ L++ +RLT+ L E E E+EQ+K + L+EE R K SS LV
Sbjct: 1606 K-------LQELNQRLTEMLCQKEKEPGNSALEEREQEKFN--LKEELERCKVQSSTLVS 1656
Query: 184 -LECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF 242
LE + + K + LK E EK + +L+ +++ + EK L E
Sbjct: 1657 SLEAELSEVKIQTHIVQQENHLLKDELEKMKQLHRCPDLSDFQQKISSVLSYNEKLLKEK 1716
Query: 243 DIEREQLR------AKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQL 290
+ E+L AK + E+R T+K+E +S + HQ +S QL
Sbjct: 1717 EALSEELNSCVDKLAKSSLLEHRIATMKQEQKSWE---------HQSASLKSQL 1761
Score = 40.4 bits (93), Expect = 0.005
Identities = 49/205 (23%), Positives = 83/205 (40%), Gaps = 42/205 (20%)
Query: 94 QERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFE--- 150
QE++ S + ++ +L E+ QR Q+ E +E E R T Q+E +
Sbjct: 767 QEQLTSLVEKHTLEKEELRKELLEKHQRELQEGRE------KMETECNRRTSQIEAQFQS 820
Query: 151 -------------KSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+S ++ +E K L Q EE+S+ + L EC +A E
Sbjct: 821 DCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEKDELTQECAEAQELLKE-- 878
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE 257
+LK EK S V E E+ E ++ L+ +ER+QL L
Sbjct: 879 ------TLKREKTTSLVLTQEREM---------LEKTYKEHLNSMVVERQQLLQDLEDLR 923
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQ 282
N ++T + L + +L++SH+
Sbjct: 924 NVSET---QQSLLSDQILELKSSHK 945
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/287 (20%), Positives = 119/287 (41%), Gaps = 52/287 (18%)
Query: 26 DLVIEALKAQHRDTF------IEERYGKYN--ISDPLMALQRDFETLKEKNDGEKQPVCT 77
+LVIE +K QH +E++ Y + + +++ ++ E +K++++ E
Sbjct: 608 ELVIEQMKEQHHRDICCLRLELEDKVRHYEKQLDETVVSCKKAQENMKQRHENETHT--- 664
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
L+ + KN + Q A + H E RH E
Sbjct: 665 -----LEKQISDLKNEIAELQGQAAVLKEAHH-------EATCRH--------------E 698
Query: 138 KERERLTQQLEFEKSQVK-------KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKAT 190
+E+++L +LE EK+ ++ + E + + +Q ER R SS E +
Sbjct: 699 EEKKQLQVKLEEEKTHLQEKLRLQHEMELKARLTQAQASFEREREGLQSSAWTEEKVRGL 758
Query: 191 NKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR 250
+ E+ + +L+ +EK +L +EL + +R LQ EK +E + Q+
Sbjct: 759 TQELEQFHQE-QLTSLVEKHTLEKEELRKELLEKHQRELQEGR--EKMETECNRRTSQIE 815
Query: 251 AKLNRE-ENRTKTLKEEMESL----KKIVKDLEASHQHSSPNEQLKK 292
A+ + + T+ + ++SL ++ +KDL+ + + +K
Sbjct: 816 AQFQSDCQKVTERCESALQSLEGRYRQELKDLQEQQREEKSQWEFEK 862
Score = 37.0 bits (84), Expect = 0.056
Identities = 36/191 (18%), Positives = 86/191 (45%), Gaps = 9/191 (4%)
Query: 107 RHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFE-----KEQ 161
+H+ I +LE E+ + + T + + +L K+++ L+ + E+ + + E
Sbjct: 1446 QHQATIAELELEKTKLQELTRKLKERVTILVKQKDVLSHGEKEEELKAMMHDLQITCSEM 1505
Query: 162 KKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEEL 221
++ L E + +Q +S+L E + + K G L+ E+ + +++E
Sbjct: 1506 QQKVELLRYESEKLQQENSILRNEITTLNEEDSISNLKLGTLNGSQEEMWQKTETVKQEN 1565
Query: 222 AAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASH 281
AA +K ++KQ+SE I+ +QL + + +E+++ L + + ++
Sbjct: 1566 AAVQKM----VENLKKQISELKIKNQQLDLENTELSQKNSQNQEKLQELNQRLTEMLCQK 1621
Query: 282 QHSSPNEQLKK 292
+ N L++
Sbjct: 1622 EKEPGNSALEE 1632
Score = 32.0 bits (71), Expect = 1.8
Identities = 72/349 (20%), Positives = 143/349 (40%), Gaps = 53/349 (15%)
Query: 4 EKLSKPELLTLFSILEGELEARDLVI------EALKAQHRDTF-IEERYGKYNISDPLMA 56
+ L ++L L S + EL R+ V+ E L +Q + +E + + L+A
Sbjct: 930 QSLLSDQILELKSSHKRELREREEVLCQAGASEQLASQRLERLEMEHDQERQEMMSKLLA 989
Query: 57 LQRDFETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLE 116
++ + E D E+ + T + + + K MQ+ S L+ +S + VI + E
Sbjct: 990 MENIHKATCETADRERAEMSTE----ISRLQSKIKEMQQAT-SPLSMLQSGCQ-VIGEEE 1043
Query: 117 EER-------QRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKL----- 164
E Q+ Q E DV L++ E+ ++ +++ + ++ +KL
Sbjct: 1044 VEGDGALSLLQQGEQLLEENGDVLLSLQRAHEQAVKENVKMATEISRLQQRLQKLEPGLV 1103
Query: 165 -SSQLEE-----------------ERSRHKQLSSMLV------LECKKATNKAAEEGQKA 200
SS L+E +++R KQ+ + LE + + +
Sbjct: 1104 MSSCLDEPATEFFGNTAEQTEPFLQQNRTKQVEGVTRRHVLSDLEDDEVRDLGSTGTSSV 1163
Query: 201 GELSLKLEKEKSRVSKLEEELAAERKRGLQTEA-QVEKQLSEFDIEREQLRAKLNREENR 259
+K+E+ ++ V E +E R TE+ +++ Q+S+ + L A +R +
Sbjct: 1164 QRQEVKIEESEASVEGFSELENSEETR---TESWELKNQISQLQEQLMMLCADCDRASEK 1220
Query: 260 TKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTATEPLMLM 308
+ L ++ LKK +K LE + S + L + V+ E L +M
Sbjct: 1221 KQDLLFDVSVLKKKLKMLERIPEASPKYKLLYEDVSRENDCLQEELRMM 1269
Score = 31.2 bits (69), Expect = 3.1
Identities = 32/157 (20%), Positives = 62/157 (39%), Gaps = 39/157 (24%)
Query: 137 EKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
E+ + L ++LE S+ + Q++L + +EE
Sbjct: 2005 ERINQHLQEELENRTSETNTPQGNQEQLVTVMEER------------------------- 2039
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
+++E++ V +L +E + K L + + + + +E QL L
Sbjct: 2040 -------MIEVEQKLKLVKRLLQEKVNQLKEQLCKNTKADAMVKDLYVENAQLLKALEVT 2092
Query: 257 ENRTKT-------LKEEMESLKKIVKDLEASHQHSSP 286
E R KT L+E++ SL IV++L + S+P
Sbjct: 2093 EQRQKTAEKKNYLLEEKIASLSNIVRNLTPAPLTSTP 2129
Score = 30.8 bits (68), Expect = 4.0
Identities = 33/152 (21%), Positives = 70/152 (46%), Gaps = 20/152 (13%)
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEE-----ERSRHKQLSSM---- 181
++ ++LE+ +++ ++ E +S + K EK + ++S++++ ER L +
Sbjct: 368 EIRHLLERV-DQVVREKEKLRSDLDKAEKLKSLMASEVDDHHAAIERRNEYNLRKLDEEY 426
Query: 182 --LVLECKKATNKAAEEG-QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ 238
+ K K E+ Q+AG+ L+LE+E + E + L+ +++E +
Sbjct: 427 KERIAALKNELRKEREQILQQAGKQRLELEQEIEKAKTEENYIRDRLALSLKENSRLENE 486
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESL 270
L E KL EN T L+ +E++
Sbjct: 487 LLE-------NAEKLAEYENLTNKLQRNLENV 511
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 59.3 bits (142), Expect = 1e-08
Identities = 63/227 (27%), Positives = 107/227 (47%), Gaps = 33/227 (14%)
Query: 91 KNMQERM--LSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLE 148
KN+ E + L + A +R +K L+E Q+ D +D L K + +L QQ+E
Sbjct: 977 KNLTEELSGLDETIAKLTREKKA---LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE 1033
Query: 149 FEKSQVKK-------FEKEQKKLSSQLE-------EERSRHKQLSSMLV---LECKKATN 191
+S +++ E+ ++KL L+ + + +QL L E + +
Sbjct: 1034 DLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQS 1093
Query: 192 KAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRA 251
K +E + K+++ ++R+ +LEEE+ AER T A+ EKQ S++ E E+L
Sbjct: 1094 KVEDEQTLGLQFQKKIKELQARIEELEEEIEAER----ATRAKTEKQRSDYARELEELSE 1149
Query: 252 KLNREENRTKT-----LKEEMESLKKIVKDL-EASHQHSSPNEQLKK 292
+L T T K E E L K+ +DL EA+ QH + L+K
Sbjct: 1150 RLEEAGGVTSTQIELNKKREAEFL-KLRRDLEEATLQHEAMVAALRK 1195
Score = 57.0 bits (136), Expect = 5e-08
Identities = 58/209 (27%), Positives = 102/209 (48%), Gaps = 24/209 (11%)
Query: 105 ESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQV---KKFEKEQ 161
++R ++ ++E ER A+ + D LE+ ERL + +Q+ KK E E
Sbjct: 1113 QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEF 1172
Query: 162 KKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL---KLEKEKSRVSKLE 218
KL LEE +H+ + + L KK + AE G++ L KLEKEKS
Sbjct: 1173 LKLRRDLEEATLQHEAMVAALR---KKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEI 1229
Query: 219 EELAAERKRGLQTEAQVEK-------QLSEFDIEREQLR---AKLNREENRTKT----LK 264
++L++ + +++A +EK QLSE + E+++ ++L +++R +T L
Sbjct: 1230 DDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289
Query: 265 EEMESLKKIVKDLEASHQ-HSSPNEQLKK 292
++E + IV L S Q + E+LK+
Sbjct: 1290 RQLEEKESIVSQLSRSKQAFTQQTEELKR 1318
Score = 48.1 bits (113), Expect = 2e-05
Identities = 50/192 (26%), Positives = 89/192 (46%), Gaps = 35/192 (18%)
Query: 96 RMLSQLAAAESRHRKVILDLEEERQRHAQDTAE-GDDVTYMLEKERERLTQQLEFEKSQV 154
++ L A +H ++ L R++HA AE G+ + + +R+ Q+LE EKS+
Sbjct: 1174 KLRRDLEEATLQHEAMVAAL---RKKHADSVAELGEQIDNL-----QRVKQKLEKEKSEF 1225
Query: 155 K------------------KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
K EK + L QL E R +++++ L + T + +
Sbjct: 1226 KLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL----SELTTQKSRL 1281
Query: 197 GQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNRE 256
+AGELS +LE+++S VS+L A + QTE ++++QL E + + L L
Sbjct: 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQ---QTE-ELKRQLEEENKAKNALAHALQSS 1337
Query: 257 ENRTKTLKEEME 268
+ L+E+ E
Sbjct: 1338 RHDCDLLREQYE 1349
Score = 47.8 bits (112), Expect = 3e-05
Identities = 42/173 (24%), Positives = 89/173 (51%), Gaps = 19/173 (10%)
Query: 137 EKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEE 196
E E+E T + EF+K++ + + E K+ +LEE+ Q + L L+ + + +
Sbjct: 845 ETEKEMATMKEEFQKTKDELAKSEAKR--KELEEKLVTLVQEKNDLQLQVQAESENLLDA 902
Query: 197 GQKAGEL---SLKLE---KEKSRVSKLEEELAAE---RKRGLQTE-AQVEKQLSEFDIER 246
++ +L +LE KE + ++ EEE+ AE +KR L+ E ++++K + + ++
Sbjct: 903 EERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTL 962
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIV-------KDLEASHQHSSPNEQLKK 292
++ + + EN+ K L EE+ L + + K L+ +HQ + + Q ++
Sbjct: 963 AKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Score = 46.2 bits (108), Expect = 9e-05
Identities = 51/203 (25%), Positives = 98/203 (48%), Gaps = 23/203 (11%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ 146
M K ++ +LA +E++ + +LEE+ Q E +D+ ++ E E L
Sbjct: 850 MATMKEEFQKTKDELAKSEAKRK----ELEEKLVTLVQ---EKNDLQLQVQAESENLLDA 902
Query: 147 LEFEKSQVK-KFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSL 205
E +K KF+ E K ++ E +++++ L + +K ++ +E + +L L
Sbjct: 903 EERCDQLIKAKFQLEAK--IKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLEL 960
Query: 206 ---KLEKEK----SRVSKLEEELAAERKRGL-QTEAQVEKQLSEFDIEREQLRAKLNREE 257
K+EKEK ++V L EEL+ GL +T A++ ++ +Q L EE
Sbjct: 961 TLAKVEKEKHATENKVKNLTEELS-----GLDETIAKLTREKKALQEAHQQALDDLQAEE 1015
Query: 258 NRTKTLKEEMESLKKIVKDLEAS 280
++ +L + L++ V+DLE+S
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESS 1038
Score = 45.4 bits (106), Expect = 2e-04
Identities = 68/338 (20%), Positives = 138/338 (40%), Gaps = 70/338 (20%)
Query: 1 MNLEKLSKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRD 60
+ L K + E L L LE + ++ AL+ +H D+ E + + + LQR
Sbjct: 1162 IELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAE-------LGEQIDNLQRV 1214
Query: 61 FETLKEKNDGEKQPVCTNPLSILKVVMKQCKNMQE---RMLSQLAAAESRHRKVILDLEE 117
+ L EK E + + S ++ V K N+++ + QL+ A ++ ++ L E
Sbjct: 1215 KQKL-EKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSE 1273
Query: 118 ----------ERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKK----------- 156
E ++ E + + L + ++ TQQ E K Q+++
Sbjct: 1274 LTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHA 1333
Query: 157 --------------FEKEQK----------KLSSQLEEERSRHKQLSSMLVLECKKATNK 192
+E+EQ+ K +S++ + R++++ + E ++A K
Sbjct: 1334 LQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393
Query: 193 AAEEGQKAGEL-------SLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQ------- 238
A+ Q + E LEK K R+ E+L + +R A ++K+
Sbjct: 1394 LAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKV 1453
Query: 239 LSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKD 276
L+E+ + E+ +A+L +++L E+ LK ++
Sbjct: 1454 LAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEE 1491
Score = 38.9 bits (89), Expect = 0.015
Identities = 63/299 (21%), Positives = 118/299 (39%), Gaps = 62/299 (20%)
Query: 18 LEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCT 77
L+GE+E DL+++ +A ++++ + D ++A +++T E++ E +
Sbjct: 1422 LQGEVE--DLMVDVERANSLAAALDKKQRNF---DKVLA---EWKTKCEESQAELEASLK 1473
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
S+ + K KN E L QL + ++ +LE+E + AE + LE
Sbjct: 1474 ESRSLSTELFK-LKNAYEEALDQLETVKRENK----NLEQEIADLTEQIAENGKTIHELE 1528
Query: 138 KER-----ERLTQQLEFEKSQVKKFEKEQKKLSSQLE-----EERSRHKQLSSMLVLECK 187
K R E+ QL E+++ +E K L QLE E R + + K
Sbjct: 1529 KSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLK 1588
Query: 188 KATNKAAEEGQKAGELSLKLEKEKSRVSK--------LEEELAAERKRGLQTE------- 232
+ + E Q A + ++ E R+ K +E +L+ ++ +T
Sbjct: 1589 RNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQ 1648
Query: 233 ------------------------AQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEM 267
A VE++ + E E+LRA L + E K ++E+
Sbjct: 1649 GQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQEL 1707
Score = 34.7 bits (78), Expect = 0.28
Identities = 50/208 (24%), Positives = 81/208 (38%), Gaps = 32/208 (15%)
Query: 47 KYNISDPLMALQRDFETLKE--KNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAA 104
K + LM LQ + E +N EK K + +E Q +A
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEEKAK---------KAITDAAMMAEELKKEQDTSA 1778
Query: 105 ESRHRKVILDLEEERQRHAQDTAE------GDDVTYMLEKERERLTQQLEFEKSQ----- 153
K L+ + +H D AE G LE L +LE E+ +
Sbjct: 1779 HLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESV 1838
Query: 154 --VKKFEKEQKKLSSQLEEERSRHKQLSSML-VLECK-KATNKAAEEGQKAGELSLKLEK 209
++K+E+ K+L+ Q EE+R +L ++ L+ K K+ + AEE + L
Sbjct: 1839 KGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHL---- 1894
Query: 210 EKSRVSKLEEELAAERKRGLQTEAQVEK 237
++ K + EL +R E+QV K
Sbjct: 1895 --TKFRKAQHELEEAEERADIAESQVNK 1920
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 59.3 bits (142), Expect = 1e-08
Identities = 61/235 (25%), Positives = 107/235 (45%), Gaps = 18/235 (7%)
Query: 71 EKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGD 130
EK N L + ++++ + + A+ ES+ + D +E Q +
Sbjct: 1280 EKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ----LQDTQELLQEETRQKLNLS 1335
Query: 131 DVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSR-HKQLSSMLVL-ECKK 188
LE+E+ L +Q E E+ K EK+ L SQL + + + L ++ L E KK
Sbjct: 1336 SRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKK 1395
Query: 189 ATNKAAEE-GQKAGELSL---KLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFD- 243
K AE Q+ E +L KLEK K+R+ + ++L + Q + +EK+ +FD
Sbjct: 1396 KLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQ 1455
Query: 244 --IEREQLRAKLNREENRTKTLKEEME----SLKKIVKD-LEASHQHSSPNEQLK 291
E + + A+ E +R + E E SL + +++ LEA + N+QL+
Sbjct: 1456 LLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLR 1510
Score = 56.2 bits (134), Expect = 9e-08
Identities = 74/316 (23%), Positives = 135/316 (42%), Gaps = 60/316 (18%)
Query: 19 EGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTN 78
E EL+A+D E LK + + T +E + ++ + L+EKN +Q
Sbjct: 851 EEELQAKDE--ELLKVKEKQTKVEGELEEME--------RKHQQLLEEKNILAEQLQAET 900
Query: 79 PLSI----LKVVMKQCKNMQERMLSQLAAA--ESRHRKVILDLEEER-QRHAQDTAEGDD 131
L ++ + K E +L L + E R IL E+++ Q H QD E D
Sbjct: 901 ELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 132 VTYMLEKERERLTQQLEFEK----SQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK 187
E E Q+L+ EK +++KK E+E L Q + + K+L + EC
Sbjct: 961 -------EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ-NSKFIKEKKLMEDRIAEC- 1011
Query: 188 KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTE----------AQVEK 237
+++ AEE +KA L+ K++ +S LEE L E K + E ++
Sbjct: 1012 --SSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069
Query: 238 QLSEFDIEREQLRAKLNREE------------------NRTKTLKEEMESLKKIVKDLEA 279
Q++E + ++L+ +L ++E N K ++E + ++ +D E+
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFES 1129
Query: 280 SHQHSSPNEQLKKPVT 295
+ E+ K+ ++
Sbjct: 1130 EKASRNKAEKQKRDLS 1145
Score = 55.8 bits (133), Expect = 1e-07
Identities = 53/225 (23%), Positives = 99/225 (44%), Gaps = 20/225 (8%)
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
N L +++ + Q +QE S+ A+ ++ K DL EE + + + D T +
Sbjct: 1108 NALKVVRELQAQIAELQEDFESE-KASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166
Query: 138 KERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
+ R + Q++ K K E+E K +Q+++ R RH A + +E+
Sbjct: 1167 ELRTKREQEVAELK---KALEEETKNHEAQIQDMRQRHAT-----------ALEELSEQL 1212
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREE 257
++A LEK K + +ELA E K Q +A+ E + + D + ++L AK++ +
Sbjct: 1213 EQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGD 1272
Query: 258 NRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTVSKGTAT 302
L E+ L+ E + + E KK + +K A+
Sbjct: 1273 RLRVELAEKASKLQN-----ELDNVSTLLEEAEKKGIKFAKDAAS 1312
Score = 55.5 bits (132), Expect = 2e-07
Identities = 57/267 (21%), Positives = 111/267 (41%), Gaps = 36/267 (13%)
Query: 22 LEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCTNPLS 81
L +R +E K ++ EE + N+ ++ALQ K+K D +
Sbjct: 1334 LSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD---------- 1383
Query: 82 ILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDV---TYMLEK 138
L + + E +K++ D E QR + D + L++
Sbjct: 1384 ----------------LGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQ 1427
Query: 139 ERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQ 198
E + LT L+ ++ EK+QKK L EE+S +S+ E +A +A E+
Sbjct: 1428 ELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKS----ISARYAEERDRAEAEAREKET 1483
Query: 199 KAGELSLKLE---KEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNR 255
KA L+ LE + K + ++L A+ + + ++ V K + E + + L ++
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 256 EENRTKTLKEEMESLKKIVKDLEASHQ 282
+ + L++E+++ + LE + Q
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQ 1570
Score = 54.3 bits (129), Expect = 3e-07
Identities = 60/267 (22%), Positives = 124/267 (46%), Gaps = 22/267 (8%)
Query: 19 EGELEAR---DLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEK--NDGEKQ 73
E E EAR + + AL++Q DT K + D L ++ E K+K D E
Sbjct: 1353 EEEEEARKNLEKQVLALQSQLADT-------KKKVDDDLGTIE-SLEEAKKKLLKDAEAL 1404
Query: 74 PVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVT 133
++ +++ KN ++ L L R+V +LE+++++ Q AE ++
Sbjct: 1405 SQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSIS 1464
Query: 134 YMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSML--VLECKKATN 191
+ER+R + ++++ + ++ EE ++KQL + + ++ K
Sbjct: 1465 ARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVG 1524
Query: 192 KAAEEGQKAGE-LSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLR 250
K E +K+ L ++E+ ++++ +LE+EL A L+ E ++ ++F+ + Q R
Sbjct: 1525 KNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL-QTR 1583
Query: 251 AKLNREENR-----TKTLKEEMESLKK 272
+ N E+ R + L+ E+E +K
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERK 1610
Score = 49.3 bits (116), Expect = 1e-05
Identities = 61/277 (22%), Positives = 123/277 (44%), Gaps = 33/277 (11%)
Query: 10 ELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPL--MALQRDFETLKEK 67
EL + L+ + E+ + Q RD E K + D L A Q++ T +E+
Sbjct: 1115 ELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQ 1174
Query: 68 NDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTA 127
E + K + ++ KN + +Q+ RH + +L E+ ++ + A
Sbjct: 1175 EVAE----------LKKALEEETKNHE----AQIQDMRQRHATALEELSEQLEQAKRFKA 1220
Query: 128 EGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECK 187
+ LE + + L +++ + + E ++KKL +Q++E ++ + + V
Sbjct: 1221 NLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV---- 1276
Query: 188 KATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEF-DIER 246
E +KA +L + E VS L EE + + + A +E QL + ++ +
Sbjct: 1277 -------ELAEKASKL----QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQ 1325
Query: 247 EQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQH 283
E+ R KLN +R + L+EE SL++ ++ E + ++
Sbjct: 1326 EETRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKN 1361
Score = 48.9 bits (115), Expect = 1e-05
Identities = 55/235 (23%), Positives = 109/235 (46%), Gaps = 14/235 (5%)
Query: 87 MKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQ 146
+ + +N QE M+S L + K +LE+ +++ +T + D L+ + + L Q
Sbjct: 1025 LAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQ 1084
Query: 147 LEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLK 206
L KK E+ Q L+ +E ++ L + L+ + A + E +KA K
Sbjct: 1085 L------AKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRN--K 1136
Query: 207 LEKEKSRVSKLEEELAAERKRGLQTEAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEE 266
EK+K +S+ E L E + L T A ++ ++ + E +L+ L E + ++
Sbjct: 1137 AEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQD 1196
Query: 267 ME-----SLKKIVKDLEASHQHSSPNEQLKKPV-TVSKGTATEPLMLMSVFCQTE 315
M +L+++ + LE + + + E+ K+ + T +K A E +L V ++E
Sbjct: 1197 MRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/175 (25%), Positives = 86/175 (49%), Gaps = 25/175 (14%)
Query: 142 RLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQL---SSMLVLECKKATNKAAEEGQ 198
R ++L+ + ++ K +++Q K+ +LEE +H+QL ++L + + T AE +
Sbjct: 849 RQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEE 908
Query: 199 KAGELSLK-------LEKEKSRVSKLEE--ELAAERKRGLQTEAQ-VEKQLSEFDIEREQ 248
L+ K L +SRV + EE ++ K+ +Q Q +E+QL E + R++
Sbjct: 909 MRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQK 968
Query: 249 LRAKLNREENRTKTLKEEMESL----------KKIVKD--LEASHQHSSPNEQLK 291
L+ + E + K ++EE+ L KK+++D E S Q + E+ K
Sbjct: 969 LQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Score = 44.7 bits (104), Expect = 3e-04
Identities = 47/207 (22%), Positives = 90/207 (43%), Gaps = 27/207 (13%)
Query: 18 LEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCT 77
LE ELE +E L + R T ++ D L A + +K+D +Q +
Sbjct: 1741 LEEELEEEQSNMELLNDRFRKTTLQV--------DTLNAELAAERSAAQKSDNARQQLER 1792
Query: 78 NPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEEERQRHAQDTAEGDDVTYMLE 137
K + + + ++ + S+ A S I LEE+ ++ A++ A + + E
Sbjct: 1793 QN----KELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848
Query: 138 KERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEERSRHKQLSSMLVLECKKATNKAAEEG 197
K+ + + Q+E E+ ++++ Q+E+ +R KQL K+ +A EE
Sbjct: 1849 KKLKEIFMQVEDERRHADQYKE-------QMEKANARMKQL--------KRQLEEAEEEA 1893
Query: 198 QKAGELSLKLEKEKSRVSKLEEELAAE 224
+A KL++E ++ E L+ E
Sbjct: 1894 TRANASRRKLQRELDDATEANEGLSRE 1920
Score = 37.7 bits (86), Expect = 0.033
Identities = 51/302 (16%), Positives = 123/302 (40%), Gaps = 25/302 (8%)
Query: 7 SKPELLTLFSILEGELEARDLVIEALKAQHRDTFIEERYGKYNISD---PLMALQRDFET 63
++ E++ L+ +++ +E +A + F + + + + ++ LQ + +
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELAS 1698
Query: 64 LK------EKNDGEKQPVCTNPLSILKVVMKQCKNMQERMLSQLAAAESRHRKVILDLEE 117
+ E+ E TN S ++ + + ++ R +A E + ++E
Sbjct: 1699 SERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR----IAQLEEELEEEQSNMEL 1754
Query: 118 ERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEE-RSRHK 176
R + T + D + L ER Q+ + + Q+++ KE K +LE +S+ K
Sbjct: 1755 LNDRFRKTTLQVDTLNAELAAERSA-AQKSDNARQQLERQNKELKAKLQELEGAVKSKFK 1813
Query: 177 QLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVE 236
S L + + + +E ++ + + + + ++ ++ ++ ER+ Q + Q+E
Sbjct: 1814 ATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQME 1873
Query: 237 KQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLKKPVTV 296
K + +QL+ +L E L++ + D + NE L + V+
Sbjct: 1874 KA----NARMKQLKRQLEEAEEEATRANASRRKLQRELDDA------TEANEGLSREVST 1923
Query: 297 SK 298
K
Sbjct: 1924 LK 1925
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.123 0.333
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,286,413
Number of Sequences: 37866
Number of extensions: 1479379
Number of successful extensions: 25479
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 537
Number of HSP's successfully gapped in prelim test: 1753
Number of HSP's that attempted gapping in prelim test: 11793
Number of HSP's gapped (non-prelim): 9784
length of query: 639
length of database: 18,247,518
effective HSP length: 109
effective length of query: 530
effective length of database: 14,120,124
effective search space: 7483665720
effective search space used: 7483665720
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.