BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|241896933 WD repeat domain 25 [Homo sapiens] (544 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|241896935 WD repeat domain 25 [Homo sapiens] 1131 0.0 gi|241896933 WD repeat domain 25 [Homo sapiens] 1131 0.0 gi|7706657 cell division cycle 40 homolog [Homo sapiens] 149 8e-36 gi|16554629 WD repeat domain 5 [Homo sapiens] 109 6e-24 gi|16554627 WD repeat domain 5 [Homo sapiens] 109 6e-24 gi|23199987 WD repeat domain 5B [Homo sapiens] 94 2e-19 gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 70 6e-12 gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 70 6e-12 gi|113865883 WD repeat domain 38 [Homo sapiens] 69 8e-12 gi|32189425 WD repeat domain 69 [Homo sapiens] 69 1e-11 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 68 2e-11 gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 64 4e-10 gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 62 1e-09 gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 62 1e-09 gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 62 1e-09 gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 60 4e-09 gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 60 4e-09 gi|18874090 WD repeat domain 48 [Homo sapiens] 60 5e-09 gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 59 1e-08 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 59 1e-08 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 59 1e-08 gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 59 1e-08 gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 59 1e-08 gi|134133292 WD repeat domain 27 [Homo sapiens] 57 6e-08 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 56 7e-08 gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] 56 1e-07 gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 56 1e-07 gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 56 1e-07 gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 56 1e-07 gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 56 1e-07 >gi|241896935 WD repeat domain 25 [Homo sapiens] Length = 544 Score = 1131 bits (2926), Expect = 0.0 Identities = 544/544 (100%), Positives = 544/544 (100%) Query: 1 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA Sbjct: 1 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60 Query: 61 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS Sbjct: 61 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120 Query: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR Sbjct: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180 Query: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF Sbjct: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240 Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW Sbjct: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA Sbjct: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN Sbjct: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE Sbjct: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM Sbjct: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540 Query: 541 KIWH 544 KIWH Sbjct: 541 KIWH 544 >gi|241896933 WD repeat domain 25 [Homo sapiens] Length = 544 Score = 1131 bits (2926), Expect = 0.0 Identities = 544/544 (100%), Positives = 544/544 (100%) Query: 1 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA Sbjct: 1 MTARTLSLMASLVAYDDSDSEAETEHAGSFNATGQQKDTSGVARPPGQDFASGTLDVPKA 60 Query: 61 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS Sbjct: 61 GAQPTKHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTS 120 Query: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR Sbjct: 121 HVPASHMPLAAARFKQVKLSRNFPKSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRR 180 Query: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF Sbjct: 181 LRQRQALSTETGKGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLF 240 Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW Sbjct: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA Sbjct: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN Sbjct: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE Sbjct: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM Sbjct: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540 Query: 541 KIWH 544 KIWH Sbjct: 541 KIWH 544 >gi|7706657 cell division cycle 40 homolog [Homo sapiens] Length = 579 Score = 149 bits (375), Expect = 8e-36 Identities = 83/313 (26%), Positives = 159/313 (50%), Gaps = 13/313 (4%) Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293 +P+K + GH V+ ++ P+ H+LLS SMD K+W CL+T+ H++ Sbjct: 276 LPKKQIHVWSGHTKGVSAVRLFPL--SGHLLLSCSMDCKIKLWEVYGERRCLRTFIGHSK 333 Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT-TLKFHPKD--HNIFL 350 AVR + G + LS +D L L D ETG Q S ++ ++ +KF+P + N+F+ Sbjct: 334 AVRDICFNTAGTQFLSAAYDRYLKLWDTETG-QCISRFTNRKVPYCVKFNPDEDKQNLFV 392 Query: 351 CGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAW 410 G ++ WDIR+G++++ Y + I+F+ E F+S++D D+++ W Sbjct: 393 AGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSD-------DKSLRVW 445 Query: 411 DFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGH 470 ++ + P++ L P Q+ N + +F +R+++++ ++GH Sbjct: 446 EWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGH 505 Query: 471 KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV 530 V GY+ + SP +++G +G++ ++ ++T + H + C+G +HP S Sbjct: 506 MVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSK 565 Query: 531 LATCSWGGDMKIW 543 + TC W G +K+W Sbjct: 566 VITCGWDGLIKLW 578 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 109 bits (273), Expect = 6e-24 Identities = 86/310 (27%), Positives = 139/310 (44%), Gaps = 24/310 (7%) Query: 240 FHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAAR 299 F L GH V+++++ P L S+S DK K+W A D G +T S H + Sbjct: 39 FTLAGHTKAVSSVKFSP---NGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94 Query: 300 WAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSE 357 W+ ++S D L + D+ +G L G S++ + F+P+ N+ + G F Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY-VFCCNFNPQS-NLIVSGSFDES 152 Query: 358 MKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK 417 ++ WD++TGK +++ A + F R+GS +SS S D WD + Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-------SYDGLCRIWDTASGQC 205 Query: 418 ISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYS 476 + I + + P LA T N L L W Y + + Y GHK E Y Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL----WDYSKGKCLKTYTGHKNEKYC 261 Query: 477 VGCECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535 + S GG +V+GS D V +++ +T LQGHT + T HP +++A+ + Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT-ENIIASAA 320 Query: 536 WGGD--MKIW 543 D +K+W Sbjct: 321 LENDKTIKLW 330 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 109 bits (273), Expect = 6e-24 Identities = 86/310 (27%), Positives = 139/310 (44%), Gaps = 24/310 (7%) Query: 240 FHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAAR 299 F L GH V+++++ P L S+S DK K+W A D G +T S H + Sbjct: 39 FTLAGHTKAVSSVKFSP---NGEWLASSSADKLIKIWGAYD-GKFEKTISGHKLGISDVA 94 Query: 300 WAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSE 357 W+ ++S D L + D+ +G L G S++ + F+P+ N+ + G F Sbjct: 95 WSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNY-VFCCNFNPQS-NLIVSGSFDES 152 Query: 358 MKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK 417 ++ WD++TGK +++ A + F R+GS +SS S D WD + Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSS-------SYDGLCRIWDTASGQC 205 Query: 418 ISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYS 476 + I + + P LA T N L L W Y + + Y GHK E Y Sbjct: 206 LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL----WDYSKGKCLKTYTGHKNEKYC 261 Query: 477 VGCECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535 + S GG +V+GS D V +++ +T LQGHT + T HP +++A+ + Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPT-ENIIASAA 320 Query: 536 WGGD--MKIW 543 D +K+W Sbjct: 321 LENDKTIKLW 330 >gi|23199987 WD repeat domain 5B [Homo sapiens] Length = 330 Score = 94.4 bits (233), Expect = 2e-19 Identities = 79/308 (25%), Positives = 130/308 (42%), Gaps = 24/308 (7%) Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301 L GH V+++++ P L S+S D+ +W A D + Y H + W+ Sbjct: 37 LVGHTEAVSSVKFSP---NGEWLASSSADRLIIIWGAYDGKYEKTLYG-HNLEISDVAWS 92 Query: 302 PCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGFSSEMK 359 R++S D L L D+ +G L G S++ + F+P N+ + G F +K Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNY-VFCCNFNPPS-NLIISGSFDETVK 150 Query: 360 AWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKIS 419 W+++TGK +++ A + F GS +S S D WD + + Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG-------SYDGLCRIWDAASGQCLK 203 Query: 420 NQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVEGYSVG 478 + + + P L T N L L W Y R + Y GHK E Y + Sbjct: 204 TLVDDDNPPVSFVKFSPNGKYILTATLDNTLKL----WDYSRGRCLKTYTGHKNEKYCIF 259 Query: 479 CECS-PGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWG 537 S GG +V+GS D V +++ +T LQGHT + HP +++A+ + Sbjct: 260 ANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPT-ENLIASAALE 318 Query: 538 GD--MKIW 543 D +K+W Sbjct: 319 NDKTIKLW 326 >gi|153791298 mitogen-activated protein kinase organizer 1 [Homo sapiens] Length = 315 Score = 69.7 bits (169), Expect = 6e-12 Identities = 80/324 (24%), Positives = 132/324 (40%), Gaps = 47/324 (14%) Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293 +P+K L L +G V +++ + L+ DKT K+WN + G L+TYS H Sbjct: 13 LPQKRLKTLDCGQGAVRAVRFNV---DGNYCLTCGSDKTLKLWNPL-RGTLLRTYSGHGY 68 Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLC 351 V A + + SGG D A+ L D+ +G + F G + ++ T++F+ ++ + L Sbjct: 69 EVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG-KVNTVQFN-EEATVILS 126 Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRD----SADRTI 407 G S ++ WD RS + QTLD E + +SS S + S D + Sbjct: 127 GSIDSSIRCWD------CRSRRPEPVQTLD-----EARDGVSSVKVSDHEILAGSVDGRV 175 Query: 408 IAWDFRTSAKISNQI--------FHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPY 459 +D R S+ + F C ++ L + G L Sbjct: 176 RRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLG-------- 227 Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACV 519 Y+GHK + Y + C S +V+ S DG+V + + A L + Sbjct: 228 ------EYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQ 281 Query: 520 GTTYHPVLPSVLATCSWGGDMKIW 543 YHP P +L + GG ++ W Sbjct: 282 SLAYHPTEPCLLT--AMGGSVQCW 303 >gi|14150114 mitogen-activated protein kinase organizer 1 [Homo sapiens] Length = 315 Score = 69.7 bits (169), Expect = 6e-12 Identities = 80/324 (24%), Positives = 132/324 (40%), Gaps = 47/324 (14%) Query: 234 VPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTE 293 +P+K L L +G V +++ + L+ DKT K+WN + G L+TYS H Sbjct: 13 LPQKRLKTLDCGQGAVRAVRFNV---DGNYCLTCGSDKTLKLWNPL-RGTLLRTYSGHGY 68 Query: 294 AVRAARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLC 351 V A + + SGG D A+ L D+ +G + F G + ++ T++F+ ++ + L Sbjct: 69 EVLDAAGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAG-KVNTVQFN-EEATVILS 126 Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRD----SADRTI 407 G S ++ WD RS + QTLD E + +SS S + S D + Sbjct: 127 GSIDSSIRCWD------CRSRRPEPVQTLD-----EARDGVSSVKVSDHEILAGSVDGRV 175 Query: 408 IAWDFRTSAKISNQI--------FHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPY 459 +D R S+ + F C ++ L + G L Sbjct: 176 RRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDSTLRLLDKDTGELLG-------- 227 Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACV 519 Y+GHK + Y + C S +V+ S DG+V + + A L + Sbjct: 228 ------EYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQ 281 Query: 520 GTTYHPVLPSVLATCSWGGDMKIW 543 YHP P +L + GG ++ W Sbjct: 282 SLAYHPTEPCLLT--AMGGSVQCW 303 >gi|113865883 WD repeat domain 38 [Homo sapiens] Length = 314 Score = 69.3 bits (168), Expect = 8e-12 Identities = 71/261 (27%), Positives = 118/261 (45%), Gaps = 21/261 (8%) Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296 ++L+ L GH GPV ++ P H+ S S D T ++W+ V CL+ H +V Sbjct: 54 QLLWRLGGHTGPVKFCRFSP---DGHLFASASCDCTVRLWD-VARAKCLRVLKGHQRSVE 109 Query: 297 AARWAPCGRRILSGGFDFALHLTDLETG--TQLFSGRSDFRITTLKFHPKDHNIFLCGGF 354 ++P R++ SGG+D + L D+++G +L G D I + F P N G + Sbjct: 110 TVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRD-SIQSSDFSP-TVNCLATGSW 167 Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRT 414 S + WD+R S++A + +I L S++ S D+TI W T Sbjct: 168 DSTVHIWDLRMVTPAVSHQALEGHSANISCL-----CYSASGLLASGSWDKTIHIWKPTT 222 Query: 415 SAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSR-RRRYEGHKVE 473 S+ + H + S+A P E ++LA + + VW + +G V Sbjct: 223 SSLLIQLKGHVTWV-KSIAFSPDE-LWLASAGYSRMV---KVWDCNTGKCLETLKG--VL 275 Query: 474 GYSVGCECSPGGDLLVTGSAD 494 + C +P G +LV+G+AD Sbjct: 276 DVAHTCAFTPDGKILVSGAAD 296 Score = 58.9 bits (141), Expect = 1e-08 Identities = 73/323 (22%), Positives = 119/323 (36%), Gaps = 67/323 (20%) Query: 225 LNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHC 284 +NS T R+V F + H G VN+ + P MLL+ S D W SG Sbjct: 1 MNSGVPATLAVRRVKFFGQ-HGGEVNSSAFSP---DGQMLLTGSEDGCVYGWET-RSGQL 55 Query: 285 LQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFR-ITTLKFHP 343 L HT V+ R++P G S D + L D+ L + R + T+ F P Sbjct: 56 LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP 115 Query: 344 KDHNIFLCGGFSSEMKAWDIRTGKVMR---SYKATIQQTLDILFLREGSEFLSSTDASTR 400 D GG+ + WD+++G+++R ++ +IQ S+F + + Sbjct: 116 -DSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS----------SDFSPTVNCLAT 164 Query: 401 DSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYR 460 S D T+ WD R ++ + H+ Sbjct: 165 GSWDSTVHIWDLRM---VTPAVSHQAL--------------------------------- 188 Query: 461 MSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVG 520 EGH ++ C C LL +GS D + ++ T+S L+GH Sbjct: 189 -------EGHSA---NISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238 Query: 521 TTYHPVLPSVLATCSWGGDMKIW 543 + P LA+ + +K+W Sbjct: 239 IAFSPD-ELWLASAGYSRMVKVW 260 Score = 50.8 bits (120), Expect = 3e-06 Identities = 50/214 (23%), Positives = 81/214 (37%), Gaps = 48/214 (22%) Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296 K L L+GH+ V T+ + P S L S DK +W+ V SG L+ H ++++ Sbjct: 96 KCLRVLKGHQRSVETVSFSP---DSRQLASGGWDKRVMLWD-VQSGQMLRLLVGHRDSIQ 151 Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQ------------------------LFSGRS 332 ++ ++P + +G +D +H+ DL T L SG Sbjct: 152 SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSW 211 Query: 333 DFRI-------TTLKFHPKDHNIFL-------------CGGFSSEMKAWDIRTGKVMRSY 372 D I ++L K H ++ G+S +K WD TGK + + Sbjct: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271 Query: 373 KATIQQTLDILFLREGSEFLSSTDASTRDSADRT 406 K + F +G +S TR RT Sbjct: 272 KGVLDVAHTCAFTPDGKILVSGAADQTRRQISRT 305 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 68.9 bits (167), Expect = 1e-11 Identities = 70/303 (23%), Positives = 123/303 (40%), Gaps = 19/303 (6%) Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301 L GHR V I + + + S DKT K+W+ V++G C T+ HT + + Sbjct: 130 LEGHRNVVYAIAFNNPYGDK--IATGSFDKTCKLWS-VETGKCYHTFRGHTAEIVCLSFN 186 Query: 302 PCGRRILSGGFDFALHLTDLETGTQLFSGRS-DFRITTLKFHPKDHNIFLCGGFSSEMKA 360 P + +G D L D++ G ++++ R I +L F+ I + G F + Sbjct: 187 PQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRI-ITGSFDHTVVV 245 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 WD TG+ + + F + S L+ S D+T WD ++ Sbjct: 246 WDADTGRKVNILIGHCAEISSASFNWDCSLILTG-------SMDKTCKLWDATNGKCVAT 298 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 H+ S + + + A +G +FS ++ + EGH EG Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGT-ARIFSAATRKCIA---KLEGH--EGEISKIS 352 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDM 540 +P G+ L+TGS+D ++ +T L+GHT ++ +++ T S Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFN-YKGNIVITGSKDNTC 411 Query: 541 KIW 543 +IW Sbjct: 412 RIW 414 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 67.8 bits (164), Expect = 2e-11 Identities = 65/295 (22%), Positives = 116/295 (39%), Gaps = 53/295 (17%) Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301 L+GH G V + + + ML S S DKT VW++ ++G ++ HT V + A Sbjct: 105 LKGHSGAVMELHYN---TDGSMLFSASTDKTVAVWDS-ETGERVKRLKGHTSFVNSCYPA 160 Query: 302 PCGRRIL-SGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 G +++ +G D + L D+ + + ++ +++ + F+ I + GG +++K Sbjct: 161 RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQI-ISGGIDNDIKV 219 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 WD+R K+ + + + EGS LS+ + D T+ WD R A Sbjct: 220 WDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSN-------AMDNTVRVWDVRPFA---- 268 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 P+E R + + H E + C Sbjct: 269 ---------------PKE---------------------RCVKIFQGNVHNFEKNLLRCS 292 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCS 535 SP G + GSAD V ++ + L GH + +HP P +++ S Sbjct: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347 >gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo sapiens] Length = 504 Score = 63.9 bits (154), Expect = 4e-10 Identities = 55/222 (24%), Positives = 89/222 (40%), Gaps = 24/222 (10%) Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296 ++L L+GH V ++ + P ++ S S D T ++W+ V + C+Q H AV Sbjct: 255 QILATLKGHTKKVTSVVFHP---SQDLVFSASPDATIRIWS-VPNASCVQVVRAHESAVT 310 Query: 297 AARWAPCGRRILSGGFDFALHLTDLETG---TQLFSGRSDFRITTLKFHPKDHNIFLCGG 353 G +LS D +D++TG T++ S +T +FHP D IF G Sbjct: 311 GLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCAQFHP-DGLIFGTGT 369 Query: 354 FSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFR 413 S++K WD++ + ++ I F G ++ D D ++ WD R Sbjct: 370 MDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAAD-------DSSVKLWDLR 422 Query: 414 TSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST 455 F SL + +G YLAL T Sbjct: 423 KLKNFKTLQLDNNFEVKSL---------IFDQSGTYLALGGT 455 Score = 42.7 bits (99), Expect = 8e-04 Identities = 45/209 (21%), Positives = 81/209 (38%), Gaps = 14/209 (6%) Query: 336 ITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSST 395 I L P D N L GG + +D + +++ + K ++ ++ F S Sbjct: 224 ILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVV-------FHPSQ 276 Query: 396 DASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST 455 D S D TI W ++ + HE L+LH L+ ++ Y A FS Sbjct: 277 DLVFSASPDATIRIWSVPNASCVQVVRAHES-AVTGLSLHATGDYLLSSSDDQYWA-FSD 334 Query: 456 VWPYRMSRRRRYEGHKVEGYSVGC-ECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514 + R+ + E G S+ C + P G + TG+ D ++ ++ + + GH Sbjct: 335 IQTGRVLTKVTDE---TSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGH 391 Query: 515 TQACVGTTYHPVLPSVLATCSWGGDMKIW 543 + + LAT + +K+W Sbjct: 392 SGPITSIAFSE-NGYYLATAADDSSVKLW 419 Score = 33.9 bits (76), Expect = 0.39 Identities = 22/94 (23%), Positives = 41/94 (43%), Gaps = 7/94 (7%) Query: 456 VWPYRMSRRRRYEGH------KVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRAC 509 V P +S+ R+ H + G C + ++TG AD V+++ + Sbjct: 199 VKPEELSKYRQVASHVGLHSASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILA 258 Query: 510 TLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543 TL+GHT+ +HP ++ + S ++IW Sbjct: 259 TLKGHTKKVTSVVFHP-SQDLVFSASPDATIRIW 291 >gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo sapiens] Length = 589 Score = 62.0 bits (149), Expect = 1e-09 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%) Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291 + V K L L GH G V + Q + ++++S S D+T KVWNA ++G C+ T H Sbjct: 289 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 342 Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351 T VR +R++SG D L + D+ETG L + ++ D + Sbjct: 343 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 398 Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 G + +K WD T + + + + + F +G +S S D +I WD Sbjct: 399 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 449 Query: 412 FRTSAKISNQIFHERFT 428 T I H+ T Sbjct: 450 VETGNCIHTLTGHQSLT 466 Score = 61.2 bits (147), Expect = 2e-09 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%) Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323 ++S S D T +VW+ +++G CL H AVR ++ GRR++SG +DF + + D ET Sbjct: 356 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 412 Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345 G + SG D I TL H Sbjct: 413 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 472 Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 NI + G S +K WDI+TG+ +++ + + + L+ F+ ++ S D Sbjct: 473 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 526 Query: 406 TIIAWDFRTSAKISNQI 422 T+ WD +T I N + Sbjct: 527 TVKLWDLKTGEFIRNLV 543 Score = 55.8 bits (133), Expect = 1e-07 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%) Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279 Y+ H +T R L L+GH V T +Q+C + ++S S D T KVW+AV Sbjct: 237 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 291 Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336 +G CL+T HT V +++ I+SG D L + + ETG L+ S R Sbjct: 292 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 347 Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396 + H K + G + ++ WDI TG+ + + + + +G +S Sbjct: 348 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 399 Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454 + D + WD T TC V+ Q +G ++ S Sbjct: 400 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 442 Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510 VW GH + + G E ++LV+G+AD V ++ +T T Sbjct: 443 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 498 Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543 LQG + T + + T S G +K+W Sbjct: 499 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 531 >gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo sapiens] Length = 707 Score = 62.0 bits (149), Expect = 1e-09 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%) Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291 + V K L L GH G V + Q + ++++S S D+T KVWNA ++G C+ T H Sbjct: 407 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 460 Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351 T VR +R++SG D L + D+ETG L + ++ D + Sbjct: 461 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 516 Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 G + +K WD T + + + + + F +G +S S D +I WD Sbjct: 517 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 567 Query: 412 FRTSAKISNQIFHERFT 428 T I H+ T Sbjct: 568 VETGNCIHTLTGHQSLT 584 Score = 61.2 bits (147), Expect = 2e-09 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%) Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323 ++S S D T +VW+ +++G CL H AVR ++ GRR++SG +DF + + D ET Sbjct: 474 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 530 Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345 G + SG D I TL H Sbjct: 531 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 590 Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 NI + G S +K WDI+TG+ +++ + + + L+ F+ ++ S D Sbjct: 591 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 644 Query: 406 TIIAWDFRTSAKISNQI 422 T+ WD +T I N + Sbjct: 645 TVKLWDLKTGEFIRNLV 661 Score = 55.8 bits (133), Expect = 1e-07 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%) Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279 Y+ H +T R L L+GH V T +Q+C + ++S S D T KVW+AV Sbjct: 355 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 409 Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336 +G CL+T HT V +++ I+SG D L + + ETG L+ S R Sbjct: 410 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 465 Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396 + H K + G + ++ WDI TG+ + + + + +G +S Sbjct: 466 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 517 Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454 + D + WD T TC V+ Q +G ++ S Sbjct: 518 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 560 Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510 VW GH + + G E ++LV+G+AD V ++ +T T Sbjct: 561 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 616 Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543 LQG + T + + T S G +K+W Sbjct: 617 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 649 >gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo sapiens] Length = 627 Score = 62.0 bits (149), Expect = 1e-09 Identities = 53/197 (26%), Positives = 84/197 (42%), Gaps = 19/197 (9%) Query: 232 TTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLH 291 + V K L L GH G V + Q + ++++S S D+T KVWNA ++G C+ T H Sbjct: 327 SAVTGKCLRTLVGHTGGVWSSQM-----RDNIIISGSTDRTLKVWNA-ETGECIHTLYGH 380 Query: 292 TEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLC 351 T VR +R++SG D L + D+ETG L + ++ D + Sbjct: 381 TSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMG--HVAAVRCVQYDGRRVVS 436 Query: 352 GGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 G + +K WD T + + + + + F +G +S S D +I WD Sbjct: 437 GAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSG-------SLDTSIRVWD 487 Query: 412 FRTSAKISNQIFHERFT 428 T I H+ T Sbjct: 488 VETGNCIHTLTGHQSLT 504 Score = 61.2 bits (147), Expect = 2e-09 Identities = 51/197 (25%), Positives = 83/197 (42%), Gaps = 47/197 (23%) Query: 264 LLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLET 323 ++S S D T +VW+ +++G CL H AVR ++ GRR++SG +DF + + D ET Sbjct: 394 VVSGSRDATLRVWD-IETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVWDPET 450 Query: 324 --------------------GTQLFSGRSDFRIT-----------TLKFHPK-------D 345 G + SG D I TL H Sbjct: 451 ETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK 510 Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 NI + G S +K WDI+TG+ +++ + + + L+ F+ ++ S D Sbjct: 511 DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITS------SDDG 564 Query: 406 TIIAWDFRTSAKISNQI 422 T+ WD +T I N + Sbjct: 565 TVKLWDLKTGEFIRNLV 581 Score = 55.8 bits (133), Expect = 1e-07 Identities = 82/333 (24%), Positives = 132/333 (39%), Gaps = 51/333 (15%) Query: 224 YLNSHYKETTVPRKVLFH---LRGHRGPVNT-IQWCPVLSKSHMLLSTSMDKTFKVWNAV 279 Y+ H +T R L L+GH V T +Q+C + ++S S D T KVW+AV Sbjct: 275 YIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFC-----GNRIVSGSDDNTLKVWSAV 329 Query: 280 DSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGT---QLFSGRSDFRI 336 +G CL+T HT V +++ I+SG D L + + ETG L+ S R Sbjct: 330 -TGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVR- 385 Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396 + H K + G + ++ WDI TG+ + + + + +G +S Sbjct: 386 -CMHLHEKR---VVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSG-- 437 Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFS-- 454 + D + WD T TC V+ Q +G ++ S Sbjct: 438 -----AYDFMVKVWDPETE------------TCLHTLQGHTNRVYSLQFDGIHVVSGSLD 480 Query: 455 ---TVWPYRMSR-RRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACT 510 VW GH + + G E ++LV+G+AD V ++ +T T Sbjct: 481 TSIRVWDVETGNCIHTLTGH--QSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQT 536 Query: 511 LQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543 LQG + T + + T S G +K+W Sbjct: 537 LQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLW 569 >gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapiens] Length = 522 Score = 60.5 bits (145), Expect = 4e-09 Identities = 68/275 (24%), Positives = 109/275 (39%), Gaps = 33/275 (12%) Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPVLS-----KSHMLLSTSMDKTFKVWNAVDSGHCLQ 286 +VP L H LRGH V I + P + K L S + D + K+W+ +DS + Sbjct: 259 SVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWS-LDSDEPVA 317 Query: 287 TYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRS-DFRITTLKFHPKD 345 HT V W P GR + + +D + L DLE ++ + + FH +D Sbjct: 318 DIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFH-QD 376 Query: 346 HNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 ++ GG + + WD+RTG+ + + +++ I F G + S D Sbjct: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATG-------SGDN 429 Query: 406 TIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLAL-----FSTVWPY- 459 T WD R + H+ V +GN+L + +W + Sbjct: 430 TCKVWDLRQRRCVYTIPAHQNLV---------TGVKFEPIHGNFLLTGAYDNTAKIWTHP 480 Query: 460 RMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSAD 494 S + GH EG +G + S G L+ T S D Sbjct: 481 GWSPLKTLAGH--EGKVMGLDISSDGQLIATCSYD 513 Score = 58.9 bits (141), Expect = 1e-08 Identities = 55/208 (26%), Positives = 84/208 (40%), Gaps = 16/208 (7%) Query: 337 TTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396 +T+ PKD N+ C S +K W + + + + + + +++ G FL +T Sbjct: 285 STVSLDPKDVNLASCAADGS-VKLWSLDSDEPVADIEGHTVRVARVMWHPSG-RFLGTT- 341 Query: 397 ASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTV 456 DR+ WD +I +Q H +A H + LA T G L F V Sbjct: 342 -----CYDRSWRLWDLEAQEEILHQEGHSMGVY-DIAFH--QDGSLAGTGG--LDAFGRV 391 Query: 457 WPYRMSRRRRY-EGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHT 515 W R R + EGH E Y G SP G + TGS D ++ R T+ H Sbjct: 392 WDLRTGRCIMFLEGHLKEIY--GINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 449 Query: 516 QACVGTTYHPVLPSVLATCSWGGDMKIW 543 G + P+ + L T ++ KIW Sbjct: 450 NLVTGVKFEPIHGNFLLTGAYDNTAKIW 477 Score = 32.0 bits (71), Expect = 1.5 Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 7/72 (9%) Query: 479 CECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSV-------L 531 C SP +L T G ++S + TL+GH +HP L Sbjct: 237 CHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNL 296 Query: 532 ATCSWGGDMKIW 543 A+C+ G +K+W Sbjct: 297 ASCAADGSVKLW 308 >gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo sapiens] Length = 514 Score = 60.5 bits (145), Expect = 4e-09 Identities = 33/96 (34%), Positives = 52/96 (54%), Gaps = 7/96 (7%) Query: 242 LRGHRGPVNTIQWCPVLSKSH------MLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAV 295 L+ H + TI+W P ++ ML S S D T ++W+ VD G C+ T + H E V Sbjct: 387 LQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWD-VDRGICIHTLTKHQEPV 445 Query: 296 RAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331 + ++P GR + SG FD +H+ + +TG + S R Sbjct: 446 YSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYR 481 Score = 58.2 bits (139), Expect = 2e-08 Identities = 36/143 (25%), Positives = 65/143 (45%), Gaps = 15/143 (10%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 +GH VN I+W P ++L S S D T K+W+ + +C+ H + + +W+P Sbjct: 346 QGHTNEVNAIKWDPT---GNLLASCSDDMTLKIWS-MKQDNCVHDLQAHNKEIYTIKWSP 401 Query: 303 CGR---------RILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352 G + S FD + L D++ G + + + + ++ F P D G Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSP-DGRYLASG 460 Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375 F + W+ +TG ++ SY+ T Sbjct: 461 SFDKCVHIWNTQTGALVHSYRGT 483 Score = 44.7 bits (104), Expect = 2e-04 Identities = 41/179 (22%), Positives = 66/179 (36%), Gaps = 17/179 (9%) Query: 231 ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSG-------- 282 + +P LRGH V W PV S +L S S D T ++WN ++ Sbjct: 154 DVEIPPNKAVVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNLSENSTSGSTQLV 210 Query: 283 --HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRIT 337 HC++ + V + W G + +G +D + + G+ I Sbjct: 211 LRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIF 270 Query: 338 TLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTD 396 LK++ K N L G WD TG+ + + LD+ + + STD Sbjct: 271 ALKWNKKG-NFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTD 328 Score = 42.0 bits (97), Expect = 0.001 Identities = 43/223 (19%), Positives = 84/223 (37%), Gaps = 59/223 (26%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278 H+GP+ ++W K + +LS +DKT +W+A Sbjct: 265 HKGPIFALKWN---KKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNT 321 Query: 279 --------------VDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324 + ++T+ HT V A +W P G + S D L + ++ Sbjct: 322 FASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD 381 Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375 + ++ + I T+K+ P + N+ L F S ++ WD+ G + + Sbjct: 382 NCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH 441 Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKI 418 + + F +G +L+S S D+ + W+ +T A + Sbjct: 442 QEPVYSVAFSPDG-RYLAS------GSFDKCVHIWNTQTGALV 477 >gi|18874090 WD repeat domain 48 [Homo sapiens] Length = 677 Score = 60.1 bits (144), Expect = 5e-09 Identities = 52/191 (27%), Positives = 76/191 (39%), Gaps = 22/191 (11%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304 H VN I C L+S S D T KVWNA G C+ T H + V+A +A Sbjct: 74 HTDWVNDIVLC---CNGKTLISASSDTTVKVWNA-HKGFCMSTLRTHKDYVKALAYAKDK 129 Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDH----------NIFLCGGF 354 + S G D + L D+ T T L + + ++L + KD I + G Sbjct: 130 ELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGN-KDSIYSLAMNQLGTIIVSGST 188 Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRT 414 ++ WD RT + K +L R+G++ LS S+D TI W Sbjct: 189 EKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSG-------SSDGTIRLWSLGQ 241 Query: 415 SAKISNQIFHE 425 I+ H+ Sbjct: 242 QRCIATYRVHD 252 Score = 37.7 bits (86), Expect = 0.027 Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%) Query: 239 LFHLRGHRGPVNTIQWCPVLSKSH-MLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRA 297 L L+GH V + +L++ LS S D T ++W+ + C+ TY +H E V A Sbjct: 203 LMKLKGHTDNVKAL----LLNRDGTQCLSGSSDGTIRLWS-LGQQRCIATYRVHDEGVWA 257 Query: 298 ARWAPCGRRILSGGFDFALHLTDL 321 + + SGG D ++ TDL Sbjct: 258 LQVNDAFTHVYSGGRDRKIYCTDL 281 >gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] Length = 369 Score = 58.9 bits (141), Expect = 1e-08 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 R H V ++ +C S ++ S DKT KVW A L + S H VR A+++P Sbjct: 62 RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 117 Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 GR I+S D + L D + + S F +T + FHP I G + +K Sbjct: 118 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 175 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399 WD+RT ++++ Y+ + F G+ ++++ ST Sbjct: 176 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 214 Score = 55.8 bits (133), Expect = 1e-07 Identities = 59/271 (21%), Positives = 103/271 (38%), Gaps = 27/271 (9%) Query: 235 PRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEA 294 P+ + GH+ V + + P H+L S S DKT ++W G + HT Sbjct: 12 PQSRAYRFTGHKDAVTCVNFSP---SGHLLASGSRDKTVRIWVPNVKGES-TVFRAHTAT 67 Query: 295 VRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFR-ITTLKFHPKDHNIFLCGG 353 VR+ + G+ ++ D + + LFS + KF P D + + Sbjct: 68 VRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP-DGRLIVSAS 126 Query: 354 FSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFR 413 +K WD + + + SY + + ++ +F S D T+ WD R Sbjct: 127 DDKTVKLWDKSSRECVHSY---CEHGGFVTYV----DFHPSGTCIAAAGMDNTVKVWDVR 179 Query: 414 TSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYR----MSRRRRYEG 469 T + + H L+ HP +GNYL S+ + M R Y Sbjct: 180 THRLLQHYQLHSA-AVNGLSFHP---------SGNYLITASSDSTLKILDLMEGRLLYTL 229 Query: 470 HKVEGYSVGCECSPGGDLLVTGSADGRVLMY 500 H +G + S G+ +G +D +V+++ Sbjct: 230 HGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260 Score = 42.4 bits (98), Expect = 0.001 Identities = 49/246 (19%), Positives = 86/246 (34%), Gaps = 14/246 (5%) Query: 269 MDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLF 328 MD VW+ + ++ H +AV ++P G + SG D + + + Sbjct: 1 MDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59 Query: 329 SGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREG 388 R+ D F+ +K W K + S I F +G Sbjct: 60 VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119 Query: 389 SEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGN 448 +S++D D+T+ WD + + + H F + HP A N Sbjct: 120 RLIVSASD-------DKTVKLWDKSSRECVHSYCEHGGFVT-YVDFHPSGTCIAAAGMDN 171 Query: 449 YLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRA 508 + ++ V +R+ + + V G S P G+ L+T S+D + + Sbjct: 172 TVKVWD-VRTHRLLQHYQLHSAAVNGLSF----HPSGNYLITASSDSTLKILDLMEGRLL 226 Query: 509 CTLQGH 514 TL GH Sbjct: 227 YTLHGH 232 Score = 34.3 bits (77), Expect = 0.30 Identities = 44/219 (20%), Positives = 86/219 (39%), Gaps = 24/219 (10%) Query: 328 FSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILF 384 F+G D +T + F P H + G ++ W V R++ AT++ + F Sbjct: 19 FTGHKD-AVTCVNFSPSGH-LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHF 73 Query: 385 LREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLA 443 +G F++++D D+T+ W + + H + C + P + ++ Sbjct: 74 CSDGQSFVTASD-------DKTVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVS 124 Query: 444 QTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFR 503 ++ + L+ + SR + + G+ + P G + D V ++ R Sbjct: 125 ASDDKTVKLWD-----KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179 Query: 504 TASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKI 542 T Q H+ A G ++HP + L T S +KI Sbjct: 180 THRLLQHYQLHSAAVNGLSFHP-SGNYLITASSDSTLKI 217 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 58.9 bits (141), Expect = 1e-08 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 R H V ++ +C S ++ S DKT KVW A L + S H VR A+++P Sbjct: 100 RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 155 Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 GR I+S D + L D + + S F +T + FHP I G + +K Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 213 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399 WD+RT ++++ Y+ + F G+ ++++ ST Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252 Score = 52.4 bits (124), Expect = 1e-06 Identities = 57/274 (20%), Positives = 98/274 (35%), Gaps = 17/274 (6%) Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 H +GHR V + + + L S SMD VW+ + ++ H +AV + Sbjct: 14 HFKGHRDAVTCVDFS---INTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF 69 Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 +P G + SG D + + + R+ D F+ +K Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 W K + S I F +G +S++D D+T+ WD + + + Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-------DKTVKLWDKSSRECVHS 182 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 H F + HP A N + ++ V +R+ + + V G S Sbjct: 183 YCEHGGFVT-YVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSF--- 237 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514 P G+ L+T S+D + + TL GH Sbjct: 238 -HPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/117 (26%), Positives = 48/117 (41%), Gaps = 4/117 (3%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304 H G V + + P + + MD T KVW+ V + LQ Y LH+ AV + P G Sbjct: 186 HGGFVTYVDFHP---SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSG 241 Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361 +++ D L + DL G L++ T + F GG ++ W Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 39.7 bits (91), Expect = 0.007 Identities = 51/258 (19%), Positives = 104/258 (40%), Gaps = 26/258 (10%) Query: 291 HTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNI 348 H +AV ++ +++ SG D L + ++ ++ F+G D +T + F P H + Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGH-L 75 Query: 349 FLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 G ++ W V R++ AT++ + F +G F++++D D+ Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHFCSDGQSFVTASD-------DK 125 Query: 406 TIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRR 464 T+ W + + H + C + P + ++ ++ + L+ + SR Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWD-----KSSRE 178 Query: 465 RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYH 524 + + G+ + P G + D V ++ RT Q H+ A G ++H Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238 Query: 525 PVLPSVLATCSWGGDMKI 542 P + L T S +KI Sbjct: 239 P-SGNYLITASSDSTLKI 255 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 58.9 bits (141), Expect = 1e-08 Identities = 45/159 (28%), Positives = 74/159 (46%), Gaps = 8/159 (5%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 R H V ++ +C S ++ S DKT KVW A L + S H VR A+++P Sbjct: 100 RAHTATVRSVHFC---SDGQSFVTASDDKTVKVW-ATHRQKFLFSLSQHINWVRCAKFSP 155 Query: 303 CGRRILSGGFDFALHLTDLETGTQLFS--GRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 GR I+S D + L D + + S F +T + FHP I G + +K Sbjct: 156 DGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGF-VTYVDFHPSGTCI-AAAGMDNTVKV 213 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDAST 399 WD+RT ++++ Y+ + F G+ ++++ ST Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252 Score = 52.4 bits (124), Expect = 1e-06 Identities = 57/274 (20%), Positives = 98/274 (35%), Gaps = 17/274 (6%) Query: 241 HLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARW 300 H +GHR V + + + L S SMD VW+ + ++ H +AV + Sbjct: 14 HFKGHRDAVTCVDFS---INTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNF 69 Query: 301 APCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKA 360 +P G + SG D + + + R+ D F+ +K Sbjct: 70 SPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKV 129 Query: 361 WDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISN 420 W K + S I F +G +S++D D+T+ WD + + + Sbjct: 130 WATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASD-------DKTVKLWDKSSRECVHS 182 Query: 421 QIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCE 480 H F + HP A N + ++ V +R+ + + V G S Sbjct: 183 YCEHGGFVT-YVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSF--- 237 Query: 481 CSPGGDLLVTGSADGRVLMYSFRTASRACTLQGH 514 P G+ L+T S+D + + TL GH Sbjct: 238 -HPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270 Score = 45.8 bits (107), Expect = 1e-04 Identities = 31/117 (26%), Positives = 48/117 (41%), Gaps = 4/117 (3%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCG 304 H G V + + P + + MD T KVW+ V + LQ Y LH+ AV + P G Sbjct: 186 HGGFVTYVDFHP---SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSG 241 Query: 305 RRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361 +++ D L + DL G L++ T + F GG ++ W Sbjct: 242 NYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 39.7 bits (91), Expect = 0.007 Identities = 51/258 (19%), Positives = 104/258 (40%), Gaps = 26/258 (10%) Query: 291 HTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNI 348 H +AV ++ +++ SG D L + ++ ++ F+G D +T + F P H + Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKD-AVTCVNFSPSGH-L 75 Query: 349 FLCGGFSSEMKAWDIRT---GKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADR 405 G ++ W V R++ AT++ + F +G F++++D D+ Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRS---VHFCSDGQSFVTASD-------DK 125 Query: 406 TIIAWDFRTSAKISNQIFHERFT-CPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRR 464 T+ W + + H + C + P + ++ ++ + L+ + SR Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFS--PDGRLIVSASDDKTVKLWD-----KSSRE 178 Query: 465 RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYH 524 + + G+ + P G + D V ++ RT Q H+ A G ++H Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 238 Query: 525 PVLPSVLATCSWGGDMKI 542 P + L T S +KI Sbjct: 239 P-SGNYLITASSDSTLKI 255 >gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [Homo sapiens] Length = 340 Score = 58.9 bits (141), Expect = 1e-08 Identities = 69/311 (22%), Positives = 116/311 (37%), Gaps = 29/311 (9%) Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWA 301 LRGH + + W + S +L+S S D +W++ + + L + V +A Sbjct: 51 LRGHLAKIYAMHWG---TDSRLLVSASQDGKLIIWDSYTTNK-VHAIPLRSSWVMTCAYA 106 Query: 302 PCGRRILSGGFDFALHLTDLETG------TQLFSGRSDFRITTLKFHPKDHNIFLCGGFS 355 P G + GG D + L+T ++ G + + ++ +F D N + Sbjct: 107 PSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGY-LSCCRF--LDDNQIITSSGD 163 Query: 356 SEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTS 415 + WDI TG+ + + + +G F+S + D +I WD R S Sbjct: 164 TTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSG-------ACDASIKLWDVRDS 216 Query: 416 AKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGY 475 I HE ++A P F ++ LF + Y + Sbjct: 217 MCRQTFIGHES-DINAVAFFPNGYAFTTGSDDATCRLFDLRADQEL---LMYSHDNIICG 272 Query: 476 SVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQ--ACVGTTYHPVLPSVLAT 533 S G LL+ G D ++ RA L GH +C+G T + +AT Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGM---AVAT 329 Query: 534 CSWGGDMKIWH 544 SW +KIW+ Sbjct: 330 GSWDSFLKIWN 340 >gi|83779014 katanin p80 subunit B 1 [Homo sapiens] Length = 655 Score = 58.5 bits (140), Expect = 1e-08 Identities = 42/166 (25%), Positives = 75/166 (45%), Gaps = 8/166 (4%) Query: 237 KVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVR 296 K+L L GH+ + ++ + P + S S D K+W+ G C+ Y H++AVR Sbjct: 96 KILRTLMGHKANICSLDFHPY---GEFVASGSQDTNIKLWDIRRKG-CVFRYRGHSQAVR 151 Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFRITTLKFHPKDHNIFLCGGF 354 R++P G+ + S D + L DL G + F G + + ++FHP ++ + G Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG-PVNVVEFHPNEY-LLASGSS 209 Query: 355 SSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSSTDASTR 400 ++ WD+ +V+ + +LF +G S S R Sbjct: 210 DRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLR 255 Score = 43.1 bits (100), Expect = 6e-04 Identities = 46/185 (24%), Positives = 77/185 (41%), Gaps = 13/185 (7%) Query: 257 VLSK-SHMLLSTSMDKT-FKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDF 314 VL K S LL+T D +W+ ++ +C+ + + HT V + R I++G Sbjct: 27 VLGKASGRLLATGGDDCRVNLWS-INKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85 Query: 315 ALHLTDLETGTQLFSGRS-DFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYK 373 ++ + DLE L + I +L FHP + G + +K WDIR + Y+ Sbjct: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV-ASGSQDTNIKLWDIRRKGCVFRYR 144 Query: 374 ATIQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLA 433 Q + F +G S+ D D T+ WD T+ K+ ++ + Sbjct: 145 GHSQAVRCLRFSPDGKWLASAAD-------DHTVKLWDL-TAGKMMSEFPGHTGPVNVVE 196 Query: 434 LHPRE 438 HP E Sbjct: 197 FHPNE 201 Score = 30.0 bits (66), Expect = 5.7 Identities = 16/58 (27%), Positives = 27/58 (46%), Gaps = 1/58 (1%) Query: 486 DLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543 +L+V GS G + ++ A TL GH +HP +A+ S ++K+W Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHP-YGEFVASGSQDTNIKLW 132 Score = 29.3 bits (64), Expect = 9.6 Identities = 30/129 (23%), Positives = 46/129 (35%), Gaps = 16/129 (12%) Query: 402 SADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFSTVWPYRM 461 S +I WD + + + H+ C SL HP + + + L+ Sbjct: 82 SQSGSIRVWDLEAAKILRTLMGHKANIC-SLDFHPYGEFVASGSQDTNIKLWDI------ 134 Query: 462 SRRR----RYEGHKVEGYSVGC-ECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQ 516 RR+ RY GH +V C SP G L + + D V ++ GHT Sbjct: 135 -RRKGCVFRYRGHS---QAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190 Query: 517 ACVGTTYHP 525 +HP Sbjct: 191 PVNVVEFHP 199 >gi|134133292 WD repeat domain 27 [Homo sapiens] Length = 857 Score = 56.6 bits (135), Expect = 6e-08 Identities = 75/314 (23%), Positives = 121/314 (38%), Gaps = 38/314 (12%) Query: 253 QWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGF 312 QW +H+LL D + AV SGH AV A W+ R +LS Sbjct: 556 QWLACGLANHLLLV--FDASLTGTPAVFSGH--------DGAVNAVCWSQDRRWLLSAAR 605 Query: 313 DFALHLTDLETGT-QLFSGRSDFR--ITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGK-V 368 D L + L G+ F I + +F+ D I L G ++ + I T K Sbjct: 606 DGTLRMWSARGAELALLLGKDMFSKPIQSAQFYYIDAFILLSSGPEFQLLRYHIDTCKDE 665 Query: 369 MRSYKATIQQTLDILFLREGSEFLSSTDAST--------RDSADRTIIAWDFRTS----- 415 ++ YK + L G+ ++S A +RT+ +D Sbjct: 666 IKRYKQKSKSKLICRLSTTGAVDMTSLSAVNDFYSHIVLAAGRNRTVEVFDLNAGCSAAV 725 Query: 416 -AKISNQIFHERFTCPSLALHPREP----VFLAQTNGNYLALFSTVWPYRMSR-RRRYEG 469 A+ ++ H+ + ++P +FL G+ + L W R R R +EG Sbjct: 726 IAEAHSRPVHQICQNKGSSFTTQQPQAYNLFLTTAIGDGMRL----WDLRTLRCERHFEG 781 Query: 470 HKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLPS 529 H GY G SP G G+ D +Y +++ + L GHT G ++P P Sbjct: 782 HPTRGYPCGIAFSPCGRFAACGAEDRHAYVYEMGSSTFSHRLAGHTDTVTGVAFNPSAPQ 841 Query: 530 VLATCSWGGDMKIW 543 LAT + G ++++ Sbjct: 842 -LATATLDGKLQLF 854 Score = 38.5 bits (88), Expect = 0.016 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 13/116 (11%) Query: 242 LRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVW-----NAVDSGHCLQTYSLHTEAVR 296 L+GH GPV +++CP ++ L+S S D+ FKVW + + S L Y L + + Sbjct: 190 LQGHLGPVTAVEFCP--WRAGTLISASEDRGFKVWDHCTGSLIYSSSVLSAYPLLSLFID 247 Query: 297 AARWAPCGRRILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLC 351 A R++++G D L + L G R D R T F + LC Sbjct: 248 AE-----SRQLVTGCADGQLWIFSLMDGHHYRRVARVDLRKKTETFSTRRVKSGLC 298 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 56.2 bits (134), Expect = 7e-08 Identities = 38/123 (30%), Positives = 65/123 (52%), Gaps = 8/123 (6%) Query: 244 GHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPC 303 GH V+ +++ P S+ L + S DKT ++W+A G+ ++ ++ H V + ++P Sbjct: 424 GHLADVDCVKFHP---NSNYLATGSTDKTVRLWSA-QQGNSVRLFTGHRGPVLSLAFSPN 479 Query: 304 GRRILSGGFDFALHLTDLETGT--QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAW 361 G+ + S G D L L DL +GT + G +D IT+L F P D + + ++ W Sbjct: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTD-NITSLTFSP-DSGLIASASMDNSVRVW 537 Query: 362 DIR 364 DIR Sbjct: 538 DIR 540 Score = 38.9 bits (89), Expect = 0.012 Identities = 36/148 (24%), Positives = 58/148 (39%), Gaps = 19/148 (12%) Query: 402 SADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALFST-----V 456 S DRT W F + + H + HP N NYLA ST + Sbjct: 403 SHDRTARLWSFDRTYPLRIYAGHLA-DVDCVKFHP---------NSNYLATGSTDKTVRL 452 Query: 457 WPYRMSRR-RRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHT 515 W + R + GH+ G + SP G L + D R+ ++ + + L+GHT Sbjct: 453 WSAQQGNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510 Query: 516 QACVGTTYHPVLPSVLATCSWGGDMKIW 543 T+ P ++A+ S +++W Sbjct: 511 DNITSLTFSPD-SGLIASASMDNSVRVW 537 >gi|237820620 glutamate-rich WD repeat containing 1 [Homo sapiens] Length = 446 Score = 55.8 bits (133), Expect = 1e-07 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 9/127 (7%) Query: 244 GHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWN--AVDSGHC-LQTYSLHTEAVRAARW 300 GH V +QW P +++ + S S D + ++W+ A S C L T + H V W Sbjct: 259 GHTRSVEDLQWSP--TENTVFASCSADASIRIWDIRAAPSKACMLTTATAHDGDVNVISW 316 Query: 301 APCGRRILSGGFDFALHLTDL---ETGTQLFSGRSDFR-ITTLKFHPKDHNIFLCGGFSS 356 + +LSGG D AL + DL ++G+ + + + +T++++HP+D +F G Sbjct: 317 SRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQDSGVFAASGADH 376 Query: 357 EMKAWDI 363 ++ WD+ Sbjct: 377 QITQWDL 383 Score = 45.1 bits (105), Expect = 2e-04 Identities = 43/203 (21%), Positives = 77/203 (37%), Gaps = 29/203 (14%) Query: 225 LNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSG-- 282 L + ++ K +F GH G + W P ++ LL+ K +W D G Sbjct: 193 LAAFLRDEQAQMKPIFSFAGHMGEGFALDWSPRVTGR--LLTGDCQKNIHLWTPTDGGSW 250 Query: 283 HCLQT-YSLHTEAVRAARWAPCGRRILSG-GFDFALHLTDLETGTQLFSGRSDFRITTLK 340 H Q + HT +V +W+P + + D ++ + D+ +TT Sbjct: 251 HVDQRPFVGHTRSVEDLQWSPTENTVFASCSADASIRIWDIRAAPS-----KACMLTTAT 305 Query: 341 FHPKDHNIF---------LCGGFSSEMKAWDIR---TGKVMRSYKATIQQTLDILFLREG 388 H D N+ L GG +K WD+R +G + ++K + + + + Sbjct: 306 AHDGDVNVISWSRREPFLLSGGDDGALKIWDLRQFKSGSPVATFKQHVAPVTSVEWHPQD 365 Query: 389 SEFLSSTDASTRDSADRTIIAWD 411 S +++ AD I WD Sbjct: 366 SGVFAAS------GADHQITQWD 382 >gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 55.8 bits (133), Expect = 1e-07 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%) Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285 ++ ++V H L+ H + TI+W P + + ML S S D T ++W+ ++ G C Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 447 Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331 T + H E V + ++P G+ + SG FD +H+ + ++G + S R Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 +GH VN I+W P +L S S D T K+W+ + C+ H + + +W+P Sbjct: 358 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 413 Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352 G + S FD + L D+E G + + + ++ F P D G Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 472 Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375 F + W+ ++G ++ SY+ T Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGT 495 Score = 44.7 bits (104), Expect = 2e-04 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%) Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278 +N+H K E +P LRGH V W PV S +L S S D T ++WN Sbjct: 154 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 210 Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325 ++ HC++ + V + W G + +G +D + + Sbjct: 211 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 270 Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385 G+ I LK++ K N L G WD TG+ + + LD+ + Sbjct: 271 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329 Query: 386 REGSEFLSSTD 396 + STD Sbjct: 330 NNTTFASCSTD 340 Score = 39.3 bits (90), Expect = 0.009 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278 H+GP+ ++W K + +LS +DKT +W+A Sbjct: 277 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 333 Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324 + C+ +T+ HT V A +W P G + S D L + ++ Sbjct: 334 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393 Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375 + ++ + I T+K+ P + NI L F S ++ WDI G + Sbjct: 394 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 453 Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 + + F +G ++L+S S D+ + W+ Sbjct: 454 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 482 Score = 29.3 bits (64), Expect = 9.6 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%) Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528 GH+ E + C +P DLL +GS D +++ S + Q + C+ H V P Sbjct: 179 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 235 Query: 529 S--------------VLATCSWGGDMKIW 543 S +LAT S+ G +IW Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW 264 >gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 55.8 bits (133), Expect = 1e-07 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%) Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285 ++ ++V H L+ H + TI+W P + + ML S S D T ++W+ ++ G C Sbjct: 389 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 447 Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331 T + H E V + ++P G+ + SG FD +H+ + ++G + S R Sbjct: 448 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 493 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 +GH VN I+W P +L S S D T K+W+ + C+ H + + +W+P Sbjct: 358 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 413 Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352 G + S FD + L D+E G + + + ++ F P D G Sbjct: 414 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 472 Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375 F + W+ ++G ++ SY+ T Sbjct: 473 SFDKCVHIWNTQSGNLVHSYRGT 495 Score = 44.7 bits (104), Expect = 2e-04 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%) Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278 +N+H K E +P LRGH V W PV S +L S S D T ++WN Sbjct: 154 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 210 Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325 ++ HC++ + V + W G + +G +D + + Sbjct: 211 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 270 Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385 G+ I LK++ K N L G WD TG+ + + LD+ + Sbjct: 271 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 329 Query: 386 REGSEFLSSTD 396 + STD Sbjct: 330 NNTTFASCSTD 340 Score = 39.3 bits (90), Expect = 0.009 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278 H+GP+ ++W K + +LS +DKT +W+A Sbjct: 277 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 333 Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324 + C+ +T+ HT V A +W P G + S D L + ++ Sbjct: 334 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 393 Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375 + ++ + I T+K+ P + NI L F S ++ WDI G + Sbjct: 394 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 453 Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 + + F +G ++L+S S D+ + W+ Sbjct: 454 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 482 Score = 29.3 bits (64), Expect = 9.6 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%) Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528 GH+ E + C +P DLL +GS D +++ S + Q + C+ H V P Sbjct: 179 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 235 Query: 529 S--------------VLATCSWGGDMKIW 543 S +LAT S+ G +IW Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIW 264 >gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 55.8 bits (133), Expect = 1e-07 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%) Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285 ++ ++V H L+ H + TI+W P + + ML S S D T ++W+ ++ G C Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 498 Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331 T + H E V + ++P G+ + SG FD +H+ + ++G + S R Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 +GH VN I+W P +L S S D T K+W+ + C+ H + + +W+P Sbjct: 409 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 464 Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352 G + S FD + L D+E G + + + ++ F P D G Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 523 Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375 F + W+ ++G ++ SY+ T Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGT 546 Score = 44.7 bits (104), Expect = 2e-04 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%) Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278 +N+H K E +P LRGH V W PV S +L S S D T ++WN Sbjct: 205 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 261 Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325 ++ HC++ + V + W G + +G +D + + Sbjct: 262 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 321 Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385 G+ I LK++ K N L G WD TG+ + + LD+ + Sbjct: 322 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380 Query: 386 REGSEFLSSTD 396 + STD Sbjct: 381 NNTTFASCSTD 391 Score = 39.3 bits (90), Expect = 0.009 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278 H+GP+ ++W K + +LS +DKT +W+A Sbjct: 328 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 384 Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324 + C+ +T+ HT V A +W P G + S D L + ++ Sbjct: 385 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444 Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375 + ++ + I T+K+ P + NI L F S ++ WDI G + Sbjct: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 504 Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 + + F +G ++L+S S D+ + W+ Sbjct: 505 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 533 Score = 29.3 bits (64), Expect = 9.6 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%) Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528 GH+ E + C +P DLL +GS D +++ S + Q + C+ H V P Sbjct: 230 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 286 Query: 529 S--------------VLATCSWGGDMKIW 543 S +LAT S+ G +IW Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW 315 >gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 55.8 bits (133), Expect = 1e-07 Identities = 31/106 (29%), Positives = 57/106 (53%), Gaps = 8/106 (7%) Query: 233 TVPRKVLFH-LRGHRGPVNTIQWCPV------LSKSHMLLSTSMDKTFKVWNAVDSGHCL 285 ++ ++V H L+ H + TI+W P + + ML S S D T ++W+ ++ G C Sbjct: 440 SMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWD-IERGVCT 498 Query: 286 QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGR 331 T + H E V + ++P G+ + SG FD +H+ + ++G + S R Sbjct: 499 HTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544 Score = 55.1 bits (131), Expect = 2e-07 Identities = 36/143 (25%), Positives = 62/143 (43%), Gaps = 15/143 (10%) Query: 243 RGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAP 302 +GH VN I+W P +L S S D T K+W+ + C+ H + + +W+P Sbjct: 409 QGHTNEVNAIKWDP---SGMLLASCSDDMTLKIWS-MKQEVCIHDLQAHNKEIYTIKWSP 464 Query: 303 CGRR---------ILSGGFDFALHLTDLETGTQLFS-GRSDFRITTLKFHPKDHNIFLCG 352 G + S FD + L D+E G + + + ++ F P D G Sbjct: 465 TGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSP-DGKYLASG 523 Query: 353 GFSSEMKAWDIRTGKVMRSYKAT 375 F + W+ ++G ++ SY+ T Sbjct: 524 SFDKCVHIWNTQSGNLVHSYRGT 546 Score = 44.7 bits (104), Expect = 2e-04 Identities = 45/191 (23%), Positives = 71/191 (37%), Gaps = 23/191 (12%) Query: 225 LNSHYK------ETTVPRKVLFHLRGHRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA 278 +N+H K E +P LRGH V W PV S +L S S D T ++WN Sbjct: 205 VNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPV---SDLLASGSGDSTARIWNL 261 Query: 279 VDSG----------HCLQTYSLHTEA---VRAARWAPCGRRILSGGFDFALHLTDLETGT 325 ++ HC++ + V + W G + +G +D + + Sbjct: 262 NENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNL 321 Query: 326 QLFSGRSDFRITTLKFHPKDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFL 385 G+ I LK++ K N L G WD TG+ + + LD+ + Sbjct: 322 ASTLGQHKGPIFALKWNRKG-NYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQ 380 Query: 386 REGSEFLSSTD 396 + STD Sbjct: 381 NNTTFASCSTD 391 Score = 39.3 bits (90), Expect = 0.009 Identities = 44/216 (20%), Positives = 81/216 (37%), Gaps = 59/216 (27%) Query: 245 HRGPVNTIQWCPVLSKSHMLLSTSMDKTFKVWNA-------------------------- 278 H+GP+ ++W K + +LS +DKT +W+A Sbjct: 328 HKGPIFALKWN---RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT 384 Query: 279 ---VDSGHCL-----------QTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETG 324 + C+ +T+ HT V A +W P G + S D L + ++ Sbjct: 385 FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE 444 Query: 325 TQLFSGRS-DFRITTLKFHP-------KDHNIFLC-GGFSSEMKAWDIRTGKVMRSYKAT 375 + ++ + I T+K+ P + NI L F S ++ WDI G + Sbjct: 445 VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKH 504 Query: 376 IQQTLDILFLREGSEFLSSTDASTRDSADRTIIAWD 411 + + F +G ++L+S S D+ + W+ Sbjct: 505 QEPVYSVAFSPDG-KYLAS------GSFDKCVHIWN 533 Score = 29.3 bits (64), Expect = 9.6 Identities = 25/89 (28%), Positives = 38/89 (42%), Gaps = 17/89 (19%) Query: 469 GHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVLP 528 GH+ E + C +P DLL +GS D +++ S + Q + C+ H V P Sbjct: 230 GHESEVFI--CAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV-P 286 Query: 529 S--------------VLATCSWGGDMKIW 543 S +LAT S+ G +IW Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIW 315 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.319 0.133 0.418 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 22,848,777 Number of Sequences: 37866 Number of extensions: 1126934 Number of successful extensions: 4668 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 95 Number of HSP's successfully gapped in prelim test: 166 Number of HSP's that attempted gapping in prelim test: 3698 Number of HSP's gapped (non-prelim): 828 length of query: 544 length of database: 18,247,518 effective HSP length: 107 effective length of query: 437 effective length of database: 14,195,856 effective search space: 6203589072 effective search space used: 6203589072 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.