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Search of human proteins with 24119203
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens]
(248 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens] 470 e-133
gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens] 442 e-124
gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens] 422 e-118
gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens] 394 e-110
gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens] 367 e-102
gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens] 344 4e-95
gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens] 330 5e-91
gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens] 330 9e-91
gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens] 327 6e-90
gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens] 327 6e-90
gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens] 323 9e-89
gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens] 322 1e-88
gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens] 315 2e-86
gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens] 315 3e-86
gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens] 310 1e-84
gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens] 306 1e-83
gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens] 279 2e-75
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 78 6e-15
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 74 2e-13
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 74 2e-13
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 74 2e-13
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 72 4e-13
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 72 6e-13
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 71 8e-13
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 71 1e-12
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 69 3e-12
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 69 3e-12
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 69 3e-12
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 69 3e-12
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 69 3e-12
>gi|24119203 tropomyosin 3 isoform 2 [Homo sapiens]
Length = 248
Score = 470 bits (1210), Expect = e-133
Identities = 248/248 (100%), Positives = 248/248 (100%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLLDLNEM 248
TLLDLNEM
Sbjct: 241 TLLDLNEM 248
>gi|114155144 tropomyosin 3 isoform 4 [Homo sapiens]
Length = 248
Score = 442 bits (1138), Expect = e-124
Identities = 233/248 (93%), Positives = 240/248 (96%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
Query: 241 TLLDLNEM 248
TLLDLNEM
Sbjct: 241 TLLDLNEM 248
>gi|114155146 tropomyosin 3 isoform 3 [Homo sapiens]
Length = 247
Score = 422 bits (1085), Expect = e-118
Identities = 228/245 (93%), Positives = 231/245 (94%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLLDL 245
TL DL
Sbjct: 241 TLHDL 245
>gi|114155148 tropomyosin 3 isoform 5 [Homo sapiens]
Length = 247
Score = 394 bits (1013), Expect = e-110
Identities = 213/245 (86%), Positives = 223/245 (91%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE
Sbjct: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
EADRKYEEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQ
Sbjct: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLE++L E + L
Sbjct: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEERLYSQLERNRLLSNELKL 240
Query: 241 TLLDL 245
TL DL
Sbjct: 241 TLHDL 245
>gi|4507651 tropomyosin 4 isoform 2 [Homo sapiens]
Length = 248
Score = 367 bits (943), Expect = e-102
Identities = 188/246 (76%), Positives = 223/246 (90%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG+ ++EAVKRKIQ LQQQAD+AE+RA+ LQRE++GER RE+AE +VA+LNRRIQLVE
Sbjct: 1 MAGLNSLEAVKRKIQALQQQADEAEDRAQGLQRELDGERERREKAEGDVAALNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
EADRKYEEVARKLVI+EG+LER EERAE++E +C +++E+++ + NLK L AA EKYS+
Sbjct: 121 EADRKYEEVARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSE 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KEDKYEEEIK+L+DKLKEAETRAEFAER+VAKLEKTIDDLE+KL KEE++ + LDQ
Sbjct: 181 KEDKYEEEIKLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQ 240
Query: 241 TLLDLN 246
TL +LN
Sbjct: 241 TLNELN 246
Score = 54.7 bits (130), Expect = 7e-08
Identities = 35/161 (21%), Positives = 79/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 88 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 147
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 148 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 207
Query: 131 RKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCL 171
R + +E ++ EE+ A+ + + + L C+
Sbjct: 208 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 248
>gi|63252904 tropomyosin 1 alpha chain isoform 6 [Homo sapiens]
Length = 245
Score = 344 bits (883), Expect = 4e-95
Identities = 183/247 (74%), Positives = 215/247 (87%), Gaps = 3/247 (1%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVE 60
MAG +++EAV+RKI+ LQ+QAD AEERA LQRE++ ER+ RE AEA+VASLNRRIQLVE
Sbjct: 1 MAGSSSLEAVRRKIRSLQEQADAAEERAGTLQRELDHERKLRETAEADVASLNRRIQLVE 60
Query: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAE 120
EELDRAQERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE
Sbjct: 61 EELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAE 120
Query: 121 EADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
+ADRKYEEVARKLVIIE DLER EERAEL+E +C E++E+++ + NLK L A EKYSQ
Sbjct: 121 DADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQ 180
Query: 181 KEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
KED+YEEEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L E++ +R+ ++
Sbjct: 181 KEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDQLYQQLEQN---RRLTNE 237
Query: 241 TLLDLNE 247
L LNE
Sbjct: 238 LKLALNE 244
>gi|63252900 tropomyosin 1 alpha chain isoform 4 [Homo sapiens]
Length = 284
Score = 330 bits (847), Expect = 5e-91
Identities = 172/240 (71%), Positives = 205/240 (85%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + R+++EQ+R+MDQ LK L AAE+KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252906 tropomyosin 1 alpha chain isoform 7 [Homo sapiens]
Length = 284
Score = 330 bits (845), Expect = 9e-91
Identities = 173/242 (71%), Positives = 204/242 (84%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E + R+++EQ+R+MDQ LK L AAE+KYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELN 282
Query: 247 EM 248
M
Sbjct: 283 NM 284
>gi|114155140 tropomyosin 3 isoform 1 [Homo sapiens]
Length = 285
Score = 327 bits (838), Expect = 6e-90
Identities = 175/242 (72%), Positives = 199/242 (82%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ A+++K++ + + D E + Q ++E + AEAEVASLNRRIQLVEEELDRA
Sbjct: 44 LAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRA 103
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY
Sbjct: 104 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 163
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
EEVARKLVIIEGDLERTEERAELAES+C E++E+++ + NLK L A EKYSQKEDKYE
Sbjct: 164 EEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYE 223
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLED+L K ++ LD L D+
Sbjct: 224 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMT 283
Query: 247 EM 248
+
Sbjct: 284 SI 285
>gi|47519616 tropomyosin 2 (beta) isoform 2 [Homo sapiens]
Length = 284
Score = 327 bits (838), Expect = 6e-90
Identities = 169/241 (70%), Positives = 206/241 (85%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AESR R+++E++R MDQ LK L A+EE+YS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLE+ L KEE++ + LDQTLL+LN
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELNN 283
Query: 248 M 248
+
Sbjct: 284 L 284
>gi|63252896 tropomyosin 1 alpha chain isoform 3 [Homo sapiens]
Length = 284
Score = 323 bits (828), Expect = 9e-89
Identities = 168/240 (70%), Positives = 201/240 (83%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E +C E++E+++ + NLK L A EKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELNNM 284
>gi|63252902 tropomyosin 1 alpha chain isoform 2 [Homo sapiens]
Length = 284
Score = 322 bits (826), Expect = 1e-88
Identities = 169/242 (69%), Positives = 200/242 (82%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A ++ ++V + + D E + + + A +AEA+VASLNRRIQLVEEELDRA
Sbjct: 43 IAAKEKLLRVSEDERDRVLEELHKAEDSLLAAEEAAAKAEADVASLNRRIQLVEEELDRA 102
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
QERLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKY
Sbjct: 103 QERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKY 162
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
EEVARKLVIIE DLER EERAEL+E +C E++E+++ + NLK L A EKYSQKED+YE
Sbjct: 163 EEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYE 222
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L+DKLKEAETRAEFAERSV KLEK+IDDLE+K+ KEE+L +MLDQTLL+LN
Sbjct: 223 EEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEEKVAHAKEENLSMHQMLDQTLLELN 282
Query: 247 EM 248
M
Sbjct: 283 NM 284
>gi|223555975 tropomyosin 4 isoform 1 [Homo sapiens]
Length = 284
Score = 315 bits (808), Expect = 2e-86
Identities = 163/237 (68%), Positives = 200/237 (84%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
+++K++ + + D E + Q ++E + AE +VA+LNRRIQLVEEELDRAQER
Sbjct: 46 LQKKLKGTEDELDKYSEDLKDAQEKLELTEKKASDAEGDVAALNRRIQLVEEELDRAQER 105
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
LATALQKLEEAEKAADESERGMKVIENRA+KDEEKME+QE+QLKEAKHIAEEADRKYEEV
Sbjct: 106 LATALQKLEEAEKAADESERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEV 165
Query: 130 ARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEI 189
ARKLVI+EG+LER EERAE++E +C +++E+++ + NLK L AA EKYS+KEDKYEEEI
Sbjct: 166 ARKLVILEGELERAEERAEVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEI 225
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
K+L+DKLKEAETRAEFAER+VAKLEKTIDDLE+KL KEE++ + LDQTL +LN
Sbjct: 226 KLLSDKLKEAETRAEFAERTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELN 282
Score = 54.7 bits (130), Expect = 7e-08
Identities = 35/161 (21%), Positives = 79/161 (49%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+R ++V++ +A EE+ E + +++ + E+A+ + + R++ ++E EL+RA+ER
Sbjct: 124 ERGMKVIENRAMKDEEKMEIQEMQLKEAKHIAEEADRKYEEVARKLVILEGELERAEERA 183
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+ K + E+ +K +E + K EK + E ++K +EA+ + E
Sbjct: 184 EVSELKCGDLEEELKNVTNNLKSLEAASEKYSEKEDKYEEEIKLLSDKLKEAETRAEFAE 243
Query: 131 RKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCL 171
R + +E ++ EE+ A+ + + + L C+
Sbjct: 244 RTVAKLEKTIDDLEEKLAQAKEENVGLHQTLDQTLNELNCI 284
>gi|27597085 tropomyosin 1 alpha chain isoform 5 [Homo sapiens]
Length = 284
Score = 315 bits (806), Expect = 3e-86
Identities = 165/240 (68%), Positives = 197/240 (82%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E + R+++EQ+R+MDQ LK L AAE+KYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L K ++ LD L D+ M
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSM 284
>gi|42476296 tropomyosin 2 (beta) isoform 1 [Homo sapiens]
Length = 284
Score = 310 bits (793), Expect = 1e-84
Identities = 158/241 (65%), Positives = 198/241 (82%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
+A+++K++ + + + E + Q ++E + AEA+VASLNRRIQLVEEELDRAQ
Sbjct: 44 QALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQ 103
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
ERLATALQKLEEAEKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKYE
Sbjct: 104 ERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYE 163
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEE 187
EVARKLVI+EG+LER+EERAE+AES+C +++E+++++ NLK L A +KYS KEDKYEE
Sbjct: 164 EVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEE 223
Query: 188 EIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
EIK+L +KLKEAETRAEFAERSVAKLEKTIDDLED++ K ++ LD L D+
Sbjct: 224 EIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITS 283
Query: 248 M 248
+
Sbjct: 284 L 284
Score = 34.3 bits (77), Expect = 0.10
Identities = 18/62 (29%), Positives = 34/62 (54%)
Query: 5 TTIEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
T + + +I++L+++ +AE RAE +R V + + E EV + + + + EELD
Sbjct: 216 TKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELD 275
Query: 65 RA 66
A
Sbjct: 276 NA 277
Score = 29.3 bits (64), Expect = 3.3
Identities = 21/82 (25%), Positives = 40/82 (48%), Gaps = 9/82 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREV--------EGERRAREQAEAEVASLNRRIQL 58
++ V ++ L+ QAD + ++ + E+ E E RA E AE VA L + I
Sbjct: 197 LKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRA-EFAERSVAKLEKTIDD 255
Query: 59 VEEELDRAQERLATALQKLEEA 80
+E+E+ + + ++L+ A
Sbjct: 256 LEDEVYAQKMKYKAISEELDNA 277
>gi|63252898 tropomyosin 1 alpha chain isoform 1 [Homo sapiens]
Length = 284
Score = 306 bits (783), Expect = 1e-83
Identities = 160/240 (66%), Positives = 193/240 (80%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQE 68
++++K++ + + D E + Q ++E + AEA+VASLNRRIQLVEEELDRAQE
Sbjct: 45 SLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQE 104
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
RLATALQKLEEAEKAADESERGMKVIE+RA KDEEKME+QEIQLKEAKHIAE+ADRKYEE
Sbjct: 105 RLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEE 164
Query: 129 VARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEE 188
VARKLVIIE DLER EERAEL+E +C E++E+++ + NLK L A EKYSQKED+YEEE
Sbjct: 165 VARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEE 224
Query: 189 IKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNEM 248
IK+L+DKLKEAETRAEFAERSV KLEK+IDDLED+L K ++ LD L D+ +
Sbjct: 225 IKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI 284
Score = 49.7 bits (117), Expect = 2e-06
Identities = 30/114 (26%), Positives = 60/114 (52%)
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
+ + +K+ +++ D E +RAE AE+ + +++ + ++ L L + + DKY
Sbjct: 2 DAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYS 61
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
E +K +KL+ AE +A AE VA L + I +E++L +E + L++
Sbjct: 62 EALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEE 115
Score = 37.7 bits (86), Expect = 0.009
Identities = 33/138 (23%), Positives = 65/138 (47%), Gaps = 14/138 (10%)
Query: 102 EEKMELQEIQLKEAKHIAE--EADRKYEEVARK-----LVIIEGDLERTEERAELAESRC 154
++KM++ ++ + A AE EAD+K E K LV ++ L+ TE+ +
Sbjct: 5 KKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEAL 64
Query: 155 REMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTD-------KLKEAETRAEFAE 207
++ E++ L ++ A +++ EEE+ + KL+EAE A+ +E
Sbjct: 65 KDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESE 124
Query: 208 RSVAKLEKTIDDLEDKLK 225
R + +E E+K++
Sbjct: 125 RGMKVIESRAQKDEEKME 142
>gi|224922812 tropomyosin 2 (beta) isoform 3 [Homo sapiens]
Length = 231
Score = 279 bits (713), Expect = 2e-75
Identities = 146/242 (60%), Positives = 193/242 (79%), Gaps = 11/242 (4%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A+K+K+Q+L+ ++A +RAE+ + + + +Q E E +L ++++ E+E++
Sbjct: 1 MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVE-- 58
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
K E+EKAADESERGMKVIENRA+KDEEKMELQE+QLKEAKHIAE++DRKY
Sbjct: 59 ---------KYSESEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKY 109
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
EEVARKLVI+EG+LER+EERAE+AESR R+++E++R MDQ LK L A+EE+YS KEDKYE
Sbjct: 110 EEVARKLVILEGELERSEERAEVAESRARQLEEELRTMDQALKSLMASEEEYSTKEDKYE 169
Query: 187 EEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLN 246
EEIK+L +KLKEAETRAEFAERSVAKLEKTIDDLE+ L KEE++ + LDQTLL+LN
Sbjct: 170 EEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEETLASAKEENVEIHQTLDQTLLELN 229
Query: 247 EM 248
+
Sbjct: 230 NL 231
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 78.2 bits (191), Expect = 6e-15
Identities = 57/229 (24%), Positives = 122/229 (53%), Gaps = 14/229 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE----GERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + +Q+Q + E+ E+++R+ E E + R Q E + +I+ +EE++
Sbjct: 295 EKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEM-MWEKEEKIRELEEKM 353
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
QE++ +K +E EK ++ +R + E + + EEK+ QE +++E + + +E +
Sbjct: 354 HE-QEKIREQEEKRQEEEKIREQEKRQEQ--EAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKED 183
K E K+ E +++ EE+ E + RE +++IR ++ ++ EE ++E+
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR---EQEEMMQEQEE 467
Query: 184 KY-EEEIKILTD--KLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
K E+E K+ K++E E + E + + EK I + E+K++ +E
Sbjct: 468 KMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Score = 76.6 bits (187), Expect = 2e-14
Identities = 51/215 (23%), Positives = 107/215 (49%), Gaps = 9/215 (4%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQA-----EAEVASLNRRIQLVEEELDRAQERLAT 72
Q++ + EE+ + ++ E E+R ++A E ++ +I+ EE + +E++
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGE 415
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M+ E + + E+K+ QE +++E + + +E + K E K
Sbjct: 416 QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGK 475
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
+ E ++ EE+ E + RE +++IR +Q K E Q+E +E+E K+
Sbjct: 476 MCEQEAKMQEQEEKMRRQEEKIREQEKKIR--EQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 193 --TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
+K++E E + E + + E + E+K++
Sbjct: 534 EQEEKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQ 568
Score = 72.0 bits (175), Expect = 4e-13
Identities = 63/254 (24%), Positives = 123/254 (48%), Gaps = 31/254 (12%)
Query: 7 IEAVKRKI---------QVLQQQAD----DAEERAERLQREVEGER---RAREQAEAEVA 50
++ +KRK+ Q LQ +AD + + + +LQ +VE R +Q E ++
Sbjct: 232 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 291
Query: 51 SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI 110
+IQ EE++ +E++ +K+ E+ E E M+ E + EEK+ E
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351
Query: 111 QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAEL--AESRCREMDEQIR-----L 163
++ E + I E+ +++ EE I +R E+ A++ E + RE +E+IR +
Sbjct: 352 KMHEQEKIREQEEKRQEEEK-----IREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKI--LTDKLKEAETRAEFAERSVAKLEKTIDDLE 221
+Q K E+ + Q+E+ E+E K+ +K++E E + E + + E+ + + E
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466
Query: 222 DKLKCTKEEHLCTQ 235
+K+ +E +C Q
Sbjct: 467 EKMG-EQEGKMCEQ 479
Score = 69.3 bits (168), Expect = 3e-12
Identities = 50/227 (22%), Positives = 117/227 (51%), Gaps = 8/227 (3%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL-QREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E ++R+ +++ ++ + E E++ ++E E+ + Q E ++ +R Q E ++ R
Sbjct: 330 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKR-QEQEAKMWRQ 388
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ E E+ E E M E + + EE+M+ QE +++ + E ++K
Sbjct: 389 EEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKI 448
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK-- 184
E K+ E ++ EE+ + E + +++ ++ +Q K + EEK ++E K
Sbjct: 449 REQEEKIREQEEMMQEQEEK--MGEQEGKMCEQEAKMQEQEEK-MRRQEEKIREQEKKIR 505
Query: 185 -YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EE+I+ + ++E E + E + + E+ + + E+K++ +E+
Sbjct: 506 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 552
Score = 64.7 bits (156), Expect = 7e-11
Identities = 55/232 (23%), Positives = 105/232 (45%), Gaps = 32/232 (13%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ K++ ++ + EE+ L+ ++ + + REQ E EEE R QE+
Sbjct: 329 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ----------EEEKIREQEKR 378
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
K+ E+ E E ++ E + EEKM QE ++ E + +E + K
Sbjct: 379 QEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEK----- 433
Query: 131 RKLVIIEGDLERTEERAELAESRCREMDEQIR----LMDQNLKCLSAAEEKYSQKEDK-- 184
+ R EE+ E + RE +E+IR +M + + + E K ++E K
Sbjct: 434 ---------MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQ 484
Query: 185 -YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQ 235
EE+++ +K++E E + E + + E+ + + E+K+ +EE +C Q
Sbjct: 485 EQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM-WEQEEKMCEQ 535
Score = 62.0 bits (149), Expect = 5e-10
Identities = 49/226 (21%), Positives = 115/226 (50%), Gaps = 20/226 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + R+ + +Q++ + +E+ E+++ + E RR E + + R+ +++ E+ +
Sbjct: 288 EKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK----E 343
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E++ +K+ E EK ++ E+ E ++++EK + QE ++ EE R+ E
Sbjct: 344 EKIRELEEKMHEQEKIREQEEKRQ---EEEKIREQEKRQEQEAKMWRQ----EEKIREQE 396
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK--- 184
E R+ E ++ EE+ E + E +E+++ ++ ++ EEK ++E K
Sbjct: 397 EKIREQ---EEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR---RQEEKIREQEKKIRE 450
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EE+I+ + ++E E + E + + E + + E+K++ +E+
Sbjct: 451 QEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEK 496
Score = 60.1 bits (144), Expect = 2e-09
Identities = 39/183 (21%), Positives = 89/183 (48%), Gaps = 13/183 (7%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL---QREVEGERRAREQAEAEVASLNRRIQLVEEELD 64
E ++ + +++Q+Q + E+ E++ + E++ + + E ++ ++I+ EE++
Sbjct: 397 EKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIR 456
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
+E + +K+ E E E E M+ E + + EEK+ QE +++E + E +
Sbjct: 457 EQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 516
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK 184
+E K+ E + EE+ + E + R +E++R + L+ Q+E+K
Sbjct: 517 MMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLR----------QQEEK 566
Query: 185 YEE 187
+E
Sbjct: 567 MQE 569
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/190 (25%), Positives = 94/190 (49%), Gaps = 8/190 (4%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E +Q E E + EQ E ++ +Q EE++ R +E++
Sbjct: 387 RQEEKIREQEEKIREQEEMMQ---EQEEKMGEQEE-KMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E E+ E E M+ E + + E KM QE +++E + + K E +
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 132 KLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKY-EEEIK 190
K I E+ E+ E+ + + +M EQ M + + + EEK ++E+K E+E++
Sbjct: 503 K---IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVR 559
Query: 191 ILTDKLKEAE 200
+ + K E
Sbjct: 560 LRQQEEKMQE 569
Score = 57.0 bits (136), Expect = 1e-08
Identities = 57/246 (23%), Positives = 110/246 (44%), Gaps = 33/246 (13%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 169 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 228
Query: 67 QERLATALQKLEEA-------EKAADESERGMKV----------IENRAL------KDEE 103
Q + +KLE A + A+ G ++ +E L + EE
Sbjct: 229 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 288
Query: 104 KMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
KM QE +++E + +E + K E K+ E + EE+ E E +E+IR
Sbjct: 289 KMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+++ + +EK ++E+K +EE +K++E E R E E + + E+ I + E+K
Sbjct: 349 LEEKMH----EQEKIREQEEKRQEE-----EKIREQEKRQE-QEAKMWRQEEKIREQEEK 398
Query: 224 LKCTKE 229
++ +E
Sbjct: 399 IREQEE 404
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 50/215 (23%), Positives = 111/215 (51%), Gaps = 5/215 (2%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKI 191
K I+ E+ +E+ E + + + ++ ++ +Q K E+ + Q+E E+E K+
Sbjct: 470 K---IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM 526
Query: 192 --LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+K++E E R E + + E + +LE++L
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 70.9 bits (172), Expect = 1e-12
Identities = 61/237 (25%), Positives = 116/237 (48%), Gaps = 23/237 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRARE--------QAEAEVASL-N 53
+E+ K +IQ+ + ERA+ L Q +VE +R +E QA+ E L N
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWN 289
Query: 54 RRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
Q EE++ R +E K++E E+ E E ++ E + + EEKM QE +++
Sbjct: 290 LLNQQQEEKMWRQEE-------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
E + + K E K+ E + R EE+ + + +E +E++ ++ ++
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR---E 399
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEK +K + E++++ +K++E E E + +LE+ + D E+KL+ +E+
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Score = 67.0 bits (162), Expect = 1e-11
Identities = 53/216 (24%), Positives = 111/216 (51%), Gaps = 14/216 (6%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 84
+++ E++ R+ E + +EQ E ++ +I+ EE++ R +E++ +K+ E E
Sbjct: 293 QQQEEKMWRQ---EEKIQEQEE-KMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKM 348
Query: 85 DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE 144
E ++ E + + EEKM QE +++E +E + EE+ R+ I E+ +
Sbjct: 349 WRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE---EEMWRQEEKIREQEEKRQ 405
Query: 145 ERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAE 204
E+ E + RE DE+IR ++ + EEK + E+ +++ +KL+E E + +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMW---RQEEKIRELEEMMQDQ----EEKLREVEEKMQ 458
Query: 205 FAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
E + + E+ I E+K++ +E+ +++L Q
Sbjct: 459 EEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQ 494
Score = 66.2 bits (160), Expect = 2e-11
Identities = 50/211 (23%), Positives = 110/211 (52%), Gaps = 18/211 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + R+ + +++Q + +E+ E + R+ E R E+ + ++ ++++ +E++ +
Sbjct: 367 EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE 426
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE--IQLKEAKHIAEEADRK 125
E + +K+ E E+ + E ++ +E + ++EEKM+ QE IQ +E K I E+ ++
Sbjct: 427 EEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK-IQEQEEKT 485
Query: 126 YEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKY 185
+ + KL+ E + EE+ E + E +E+ + EEK ++E+K
Sbjct: 486 WRQ--EKLLKQEEKIWEQEEKMWRQEEKMWEQEEK----------MQEQEEKMQRQEEKM 533
Query: 186 -EEEIKI--LTDKLKEAETRAEFAERSVAKL 213
E+E+++ +K++E E R + E + KL
Sbjct: 534 REQEVRLWQQEEKMQEQEVRLQELEERLGKL 564
Score = 62.8 bits (151), Expect = 3e-10
Identities = 48/215 (22%), Positives = 113/215 (52%), Gaps = 10/215 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEI 189
+ E+ E+ E E + RE++E ++ ++ L+ + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +K++E E + + + + K E+ I + E+K+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKM 505
Score = 60.1 bits (144), Expect = 2e-09
Identities = 54/233 (23%), Positives = 115/233 (49%), Gaps = 14/233 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIR----LMDQNLKCLSAAEEKYS 179
K E ++ E + EE + E + RE++E+++ M + + + EEK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
++E+K + K+L +K+ E E + E + + E+ + + E+K++ +E+
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
Score = 59.3 bits (142), Expect = 3e-09
Identities = 45/185 (24%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ KI+ L++ D EE+ ++ +++ E ++ E ++ +IQ EE+ R QE+L
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR-QEKL 491
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+K+ E E+ E M E + + EEKM+ QE +++E + + + K +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551
Query: 131 RKLVIIEGDLERTEERAELAESRCREMDE----------QIRLMDQNLKCLSAAEEKYSQ 180
+L +E L + ++AEL RE Q+ L Q + L ++ Y
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRG 611
Query: 181 KEDKY 185
+Y
Sbjct: 612 HLQQY 616
Score = 51.2 bits (121), Expect = 8e-07
Identities = 29/121 (23%), Positives = 66/121 (54%), Gaps = 1/121 (0%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ V+ K+Q +++ + EE+ +R + +++ E+ + + ++ +I EE++ R
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K++E E+ E M+ E R + EEKM+ QE++L+E + + +K
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKA 568
Query: 127 E 127
E
Sbjct: 569 E 569
Score = 45.4 bits (106), Expect = 4e-05
Identities = 51/229 (22%), Positives = 101/229 (44%), Gaps = 35/229 (15%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDAPSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIK 190
E +L ++ EE+ E + +E +E ++ +Q LK E+ + Q+E +E+E K
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQEEK 340
Query: 191 I---------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
I +K++E E + E + + E+ I + ++K++ +EE
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 73.6 bits (179), Expect = 2e-13
Identities = 50/215 (23%), Positives = 111/215 (51%), Gaps = 5/215 (2%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLA 71
R+ + +++Q + E+ E++ R+ E R E+ + + + R+ + + E+ ++ QE++
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 72 TALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVAR 131
+K+ E ++ E E M E + + EE M+ QE +L+E + +E + K +E
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 132 KLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKI 191
K I+ E+ +E+ E + + + ++ ++ +Q K E+ + Q+E E+E K+
Sbjct: 470 K---IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKM 526
Query: 192 --LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+K++E E R E + + E + +LE++L
Sbjct: 527 QRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERL 561
Score = 70.9 bits (172), Expect = 1e-12
Identities = 61/237 (25%), Positives = 116/237 (48%), Gaps = 23/237 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL----QREVEGERRARE--------QAEAEVASL-N 53
+E+ K +IQ+ + ERA+ L Q +VE +R +E QA+ E L N
Sbjct: 230 VESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWN 289
Query: 54 RRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
Q EE++ R +E K++E E+ E E ++ E + + EEKM QE +++
Sbjct: 290 LLNQQQEEKMWRQEE-------KIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIR 342
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
E + + K E K+ E + R EE+ + + +E +E++ ++ ++
Sbjct: 343 EQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIR---E 399
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EEK +K + E++++ +K++E E E + +LE+ + D E+KL+ +E+
Sbjct: 400 QEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Score = 67.0 bits (162), Expect = 1e-11
Identities = 53/216 (24%), Positives = 111/216 (51%), Gaps = 14/216 (6%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 84
+++ E++ R+ E + +EQ E ++ +I+ EE++ R +E++ +K+ E E
Sbjct: 293 QQQEEKMWRQ---EEKIQEQEE-KMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKM 348
Query: 85 DESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTE 144
E ++ E + + EEKM QE +++E +E + EE+ R+ I E+ +
Sbjct: 349 WRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQE---EEMWRQEEKIREQEEKRQ 405
Query: 145 ERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAE 204
E+ E + RE DE+IR ++ + EEK + E+ +++ +KL+E E + +
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMW---RQEEKIRELEEMMQDQ----EEKLREVEEKMQ 458
Query: 205 FAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQ 240
E + + E+ I E+K++ +E+ +++L Q
Sbjct: 459 EEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQ 494
Score = 66.2 bits (160), Expect = 2e-11
Identities = 50/211 (23%), Positives = 110/211 (52%), Gaps = 18/211 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + R+ + +++Q + +E+ E + R+ E R E+ + ++ ++++ +E++ +
Sbjct: 367 EKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQE 426
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE--IQLKEAKHIAEEADRK 125
E + +K+ E E+ + E ++ +E + ++EEKM+ QE IQ +E K I E+ ++
Sbjct: 427 EEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEK-IQEQEEKT 485
Query: 126 YEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKY 185
+ + KL+ E + EE+ E + E +E+ + EEK ++E+K
Sbjct: 486 WRQ--EKLLKQEEKIWEQEEKMWRQEEKMWEQEEK----------MQEQEEKMQRQEEKM 533
Query: 186 -EEEIKI--LTDKLKEAETRAEFAERSVAKL 213
E+E+++ +K++E E R + E + KL
Sbjct: 534 REQEVRLWQQEEKMQEQEVRLQELEERLGKL 564
Score = 62.8 bits (151), Expect = 3e-10
Identities = 48/215 (22%), Positives = 113/215 (52%), Gaps = 10/215 (4%)
Query: 18 QQQADDAEERAERLQRE----VEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATA 73
QQQ + + E++Q + E E + REQ E ++ ++ EE++ ++++
Sbjct: 293 QQQEEKMWRQEEKIQEQEEKMCEQELKIREQEE-KMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 74 LQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQL-KEAKHIAEEADRKYEEVARK 132
+K+ E E+ E E M E + + +EK++ QE ++ ++ + I E+ +++ E++ R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 133 LVIIEGDLERTEERAE---LAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEI 189
+ E+ E+ E E + RE++E ++ ++ L+ + ++ +K + EE+I
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 190 KILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +K++E E + + + + K E+ I + E+K+
Sbjct: 472 QRQEEKIQEQEEKT-WRQEKLLKQEEKIWEQEEKM 505
Score = 60.1 bits (144), Expect = 2e-09
Identities = 54/233 (23%), Positives = 115/233 (49%), Gaps = 14/233 (6%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + + +Q E+ E++ R+ E E + REQ E ++ +I+ EE++
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQ-EDKMWRQEEKIREQEEKI 362
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K+ E ++ E E M E + + EEK QE ++ K + E+ D
Sbjct: 363 REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKR--QEKMWRQEKKMREQ-D 419
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIR----LMDQNLKCLSAAEEKYS 179
K E ++ E + EE + E + RE++E+++ M + + + EEK
Sbjct: 420 EKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQ 479
Query: 180 QKEDKYEEEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
++E+K + K+L +K+ E E + E + + E+ + + E+K++ +E+
Sbjct: 480 EQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
Score = 59.3 bits (142), Expect = 3e-09
Identities = 45/185 (24%), Positives = 85/185 (45%), Gaps = 11/185 (5%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ KI+ L++ D EE+ ++ +++ E ++ E ++ +IQ EE+ R QE+L
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWR-QEKL 491
Query: 71 ATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVA 130
+K+ E E+ E M E + + EEKM+ QE +++E + + + K +E
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551
Query: 131 RKLVIIEGDLERTEERAELAESRCREMDE----------QIRLMDQNLKCLSAAEEKYSQ 180
+L +E L + ++AEL RE Q+ L Q + L ++ Y
Sbjct: 552 VRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRG 611
Query: 181 KEDKY 185
+Y
Sbjct: 612 HLQQY 616
Score = 51.2 bits (121), Expect = 8e-07
Identities = 29/121 (23%), Positives = 66/121 (54%), Gaps = 1/121 (0%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ V+ K+Q +++ + EE+ +R + +++ E+ + + ++ +I EE++ R
Sbjct: 450 LREVEEKMQEEEEKMQEQEEKIQRQEEKIQ-EQEEKTWRQEKLLKQEEKIWEQEEKMWRQ 508
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K++E E+ E M+ E R + EEKM+ QE++L+E + + +K
Sbjct: 509 EEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKA 568
Query: 127 E 127
E
Sbjct: 569 E 569
Score = 45.4 bits (106), Expect = 4e-05
Identities = 51/229 (22%), Positives = 101/229 (44%), Gaps = 35/229 (15%)
Query: 34 EVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKV 93
EV ++R E + +++ +ER A +L+ + E+ ++
Sbjct: 164 EVTAQKRPENSLLEETLHFDHAVRMGTYIEKLTKERDALSLELYRNTITDEELKEKNAEL 223
Query: 94 IENRALKDEEKMELQEIQLKEAKHIAE-------------EADR---KYEEVARKL--VI 135
E L + EK E+Q + +K+ K E EADR + + V+ KL +
Sbjct: 224 QEKLRLVESEKSEIQ-LNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQV 282
Query: 136 IEGDL-----ERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIK 190
E +L ++ EE+ E + +E +E ++ +Q LK E+ + Q+E +E+E K
Sbjct: 283 EENELWNLLNQQQEEKMWRQEEKIQEQEE--KMCEQELKIREQEEKMWRQEEKMHEQEEK 340
Query: 191 I---------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
I +K++E E + E + + E+ I + ++K++ +EE
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEE 389
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 73.6 bits (179), Expect = 2e-13
Identities = 57/228 (25%), Positives = 112/228 (49%), Gaps = 8/228 (3%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREV-EGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E + R+ + + +Q EE + Q E+ E + REQ E + +I EE++ +
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE--IWRQKEKIHEQEEKIRKQ 555
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ + E+ E E + E + + EEK+ QE +++E + + +E + K
Sbjct: 556 EEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM 615
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
E K+ E ++ EE+ E + RE +++IR +Q K E Q+E +E
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIR--EQEEKIREQEEMMQEQEEKMWE 673
Query: 187 EEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
+E K+ +K++E E + E + + E + E+K++ +EHL
Sbjct: 674 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ-EHQEHL 720
Score = 66.2 bits (160), Expect = 2e-11
Identities = 58/240 (24%), Positives = 119/240 (49%), Gaps = 20/240 (8%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREV---EGERRAREQAEA---EVASLNRRIQLVEE 61
E +++ + +++Q E+ A+ ++E E E + REQ E + ++ + ++ EE
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Query: 62 ELDRAQERLATALQKLEEAEKA------ADESERGMKVIENRALKDEEKMELQEIQLKEA 115
E + QE + +K+ E E+ E E ++ E + + EEKM QE +++E
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
Query: 116 KHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAE 175
+ E+ R+ E++ + I E+ E+ E+ + + +M EQ M + + + E
Sbjct: 577 E---EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 633
Query: 176 EKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQ 235
EK ++E+K E+ K K++E E + E + + E+ + + E+K+ C +EE + Q
Sbjct: 634 EKMRRQEEKIREQEK----KIREQEEKIREQEEMMQEQEEKMWEQEEKM-CEQEEKMQEQ 688
Score = 65.9 bits (159), Expect = 3e-11
Identities = 57/244 (23%), Positives = 118/244 (48%), Gaps = 23/244 (9%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRARE---QAEAEVASLNRRIQLVEEELD 64
E ++R+ +++ ++ + + E + + E RR E + E ++ L ++ E+E
Sbjct: 396 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH--EQEKI 453
Query: 65 RAQERLATALQKLEEAEKAADE------SERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
R QE +K+ E EK ++ E ++ E + + EEKM QE ++ E + I
Sbjct: 454 REQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKI 513
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNL----KCLSAA 174
EE R+ +E + + + R +E + + E +E+IR ++ + + +
Sbjct: 514 REEEKRQEQEEMWR----QEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQ 569
Query: 175 EEKYSQKEDK---YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEH 231
EEK ++E+K EE+I+ +K++E E + E + E+ + + E+K+ C +EE
Sbjct: 570 EEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM-CEQEEK 628
Query: 232 LCTQ 235
+ Q
Sbjct: 629 MQEQ 632
Score = 62.4 bits (150), Expect = 4e-10
Identities = 45/201 (22%), Positives = 99/201 (49%), Gaps = 16/201 (7%)
Query: 12 RKIQVLQQQADDAEERAERLQREVEGERRAREQA---EAEVASLNRRIQLVEEELDRAQE 68
R+ + + +Q + E+ E+++++ E R E+ E ++ ++ EE++ +E
Sbjct: 533 REQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE 592
Query: 69 RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEE 128
++ +K+ E E+ E E M E + + EEKM+ QE +++ + E ++K E
Sbjct: 593 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIRE 652
Query: 129 VARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK-YEE 187
K+ E+ E+ + + +M EQ M + + + EEK ++E+K +E+
Sbjct: 653 QEEKI----------REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 702
Query: 188 EIKI--LTDKLKEAETRAEFA 206
E+++ +K++E + E A
Sbjct: 703 EVRLRQQEEKMQEHQEHLEAA 723
Score = 61.2 bits (147), Expect = 8e-10
Identities = 60/245 (24%), Positives = 114/245 (46%), Gaps = 21/245 (8%)
Query: 7 IEAVKRKI---------QVLQQQAD----DAEERAERLQREVEGER---RAREQAEAEVA 50
++ +KRK+ Q LQ +AD + + + +LQ +VE R +Q E ++
Sbjct: 305 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 364
Query: 51 SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI 110
+IQ EE++ +E++ +K+ E E+ E M E + + EE M +E
Sbjct: 365 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 424
Query: 111 QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCRE--MDEQIRLMDQNL 168
+++ + + E + K E+ K+ E E+ E+R E + R +E +++ ++ Q
Sbjct: 425 KMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE 484
Query: 169 KCLSAAEEKYSQKEDKYEEEIKI-LTDKLKEAETRAEFAE--RSVAKLEKTIDDLEDKLK 225
K E+ Q+E + +E KI +K++E E R E E R K+ + + K K
Sbjct: 485 KIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEK 544
Query: 226 CTKEE 230
++E
Sbjct: 545 IHEQE 549
Score = 56.2 bits (134), Expect = 3e-08
Identities = 40/166 (24%), Positives = 81/166 (48%), Gaps = 5/166 (3%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEG----ERRAREQAEAEVASLNRRIQLVEEEL 63
E + R+ + + Q + E+ E++ R+ E E + REQ E ++ Q EE++
Sbjct: 557 EKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEE-KIREQEEMTQEQEEKM 615
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+E++ +K++E E+ E ++ E + + EEK+ QE ++E + E +
Sbjct: 616 GEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 675
Query: 124 RKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLK 169
K E K+ E + R EE+ E R R+ +E+++ ++L+
Sbjct: 676 EKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 53.9 bits (128), Expect = 1e-07
Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 16/220 (7%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 242 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 301
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA--DR 124
Q + +KLE A+ + + +A D ELQ + K + E +R
Sbjct: 302 QLNVKELKRKLERAKLLLPQQQL-------QAEADHLGKELQSVSAKLQAQVEENELWNR 354
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK 184
++ K+ E ++ EE+ + E + RE +E+IR ++ ++ EE +KE+K
Sbjct: 355 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR---RQEEMMWEKEEK 411
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +++ +K E + E + + E+ I +LE+K+
Sbjct: 412 MRRQEEMMWEK----EEKMRRQEEMMWEKEEKIRELEEKM 447
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 72.0 bits (175), Expect = 4e-13
Identities = 54/232 (23%), Positives = 117/232 (50%), Gaps = 12/232 (5%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E ++ + + +Q E+ +R + E E+ R++ EA++ +I+ EE++ +
Sbjct: 377 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 436
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+++ +K+ E EK +E +R + E ++E+ E +EI ++ K +E RK E
Sbjct: 437 KKMWRQEEKIHEQEKIREEEKRQEQ--EEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 128 EVA----RKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLK----CLSAAEEKYS 179
E K+ E + EE+ E + RE +E+IR ++ ++ + EEK
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMG 554
Query: 180 QKEDKYEEEIKI--LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++E+K +E+ K+ +K++E E + + + + E+ I + E+K++ +E
Sbjct: 555 EQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEE 606
Score = 63.2 bits (152), Expect = 2e-10
Identities = 57/228 (25%), Positives = 107/228 (46%), Gaps = 11/228 (4%)
Query: 12 RKIQVLQQQADDAEERAERLQREV-EGERRAREQAEA----EVASLNRRIQLVEEELDRA 66
R+ + + +Q EE + Q E+ E + REQ E E +I+ EE++ R
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQ 500
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ E E+ E ++ E + + EEK+ QE ++E + E + K
Sbjct: 501 EEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKM 560
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYE 186
+E K+ E + EE+ + + RE +E+I +Q K E Q+E +E
Sbjct: 561 QE-QEKMRRQEEKIREQEEKIREQKEKIREQEEKI--WEQEEKIREQEEMMQEQEEKMWE 617
Query: 187 EEIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
+E K+ +K++E E + E + + E + E+K++ +EHL
Sbjct: 618 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ-EHQEHL 664
Score = 62.4 bits (150), Expect = 4e-10
Identities = 57/263 (21%), Positives = 120/263 (45%), Gaps = 30/263 (11%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLV---EEELD 64
E ++ + +Q+Q + E+ E+++ + E RR E + + R+ +++ EE++
Sbjct: 307 EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 366
Query: 65 RAQERLATALQKLEEAEKAADESERGMKVIENRA----LKDEEKMELQEIQLKEAKHIAE 120
R +E + +K+ E E+ E E+ + E R ++++EK + QE ++ +
Sbjct: 367 RLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 426
Query: 121 EADRKYEEVARKL-----VIIEGDLERTEERAELAESRCRE----------------MDE 159
E + K E +K+ I E + R EE+ + E R+ M E
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE 486
Query: 160 QIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT--DKLKEAETRAEFAERSVAKLEKTI 217
Q ++ Q K E+ + Q+E E+E K+ +K++E E + E + + E+ +
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMM 546
Query: 218 DDLEDKLKCTKEEHLCTQRMLDQ 240
+ E+K+ +E+ ++M Q
Sbjct: 547 QEQEEKMGEQEEKMQEQEKMRRQ 569
Score = 62.0 bits (149), Expect = 5e-10
Identities = 51/229 (22%), Positives = 111/229 (48%), Gaps = 17/229 (7%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
+ KI+ +++ + E++ R + ++ + + RE+ + + R +EE R QE +
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR----QEEKIREQEEI 477
Query: 71 ATALQKLEEAEKAADESER------GMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
+K+ E EK + E+ M E + + EEKM QE +++E + E +
Sbjct: 478 WRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEE 537
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK 184
K E + E + EE+ + E + R +E+IR ++ ++ +EK ++E+K
Sbjct: 538 KIREQEEMMQEQEEKMGEQEEKMQEQE-KMRRQEEKIREQEEKIR---EQKEKIREQEEK 593
Query: 185 ---YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EE+I+ + ++E E + E + + E+ + + E+K++ +E+
Sbjct: 594 IWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Score = 61.6 bits (148), Expect = 6e-10
Identities = 57/232 (24%), Positives = 112/232 (48%), Gaps = 29/232 (12%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
QQQ + + E++Q E E + +EQ E ++ +I+ EE++ R +E + +K+
Sbjct: 296 QQQEEKMWRQEEKIQ---EWEEKIQEQEE-KIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIE 137
E+ E E M+ +E + EEK+ E ++ E + I E+ +++ EE I
Sbjct: 352 RRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK-----IR 406
Query: 138 GDLERTEERAEL--AESRCREMDEQIRLMDQNL---------KCLSAAEEKYSQKEDKYE 186
+R E+ A++ E + RE +E+IR ++ + + EEK ++E+ +
Sbjct: 407 EQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWR 466
Query: 187 EEIKI--------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
+E KI +K+ E E + E V + E+ + D E+K++ +E+
Sbjct: 467 QEEKIREQEEIWRQKEKMHEQE-KIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Score = 60.8 bits (146), Expect = 1e-09
Identities = 65/252 (25%), Positives = 118/252 (46%), Gaps = 25/252 (9%)
Query: 7 IEAVKRKI---------QVLQQQAD----DAEERAERLQREVEGER---RAREQAEAEVA 50
++ +KRK+ Q LQ +AD + + + +LQ +VE R +Q E ++
Sbjct: 244 VKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMW 303
Query: 51 SLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEI 110
+IQ EE++ +E++ +K+ E E+ E M E + + EE M +E
Sbjct: 304 RQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 363
Query: 111 QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMD---EQIRLMDQN 167
+++ + + E + K E+ K+ E E+ E+R E E + RE + EQ M +
Sbjct: 364 KMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQE--EEKIREQEKRQEQEAKMWRQ 421
Query: 168 LKCLSAAEEKYSQKEDK-YEEEIKI-LTDKLKEAETRAEFAE--RSVAKLEKTIDDLEDK 223
+ + EEK ++E K + +E KI +K++E E R E E R K+ + + K
Sbjct: 422 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 481
Query: 224 LKCTKEEHLCTQ 235
K ++E + Q
Sbjct: 482 EKMHEQEKIRKQ 493
Score = 58.5 bits (140), Expect = 5e-09
Identities = 47/203 (23%), Positives = 99/203 (48%), Gaps = 8/203 (3%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQRE-VEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
E ++ + ++ +Q+ E+ R Q E V + E ++ ++ EE++
Sbjct: 469 EKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQ 528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKY 126
+E++ +K+ E E+ E E M E + ++++EKM QE +++E + E K
Sbjct: 529 EEKIREQEEKIREQEEMMQEQEEKMGEQEEK-MQEQEKMRRQEEKIREQEEKIREQKEKI 587
Query: 127 EEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK-Y 185
E K+ E E+ E+ E+ + + +M EQ M + + + EEK ++E+K +
Sbjct: 588 REQEEKIWEQE---EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 644
Query: 186 EEEIKI--LTDKLKEAETRAEFA 206
E+E+++ +K++E + E A
Sbjct: 645 EQEVRLRQQEEKMQEHQEHLEAA 667
Score = 53.9 bits (128), Expect = 1e-07
Identities = 48/220 (21%), Positives = 99/220 (45%), Gaps = 16/220 (7%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA--DR 124
Q + +KLE A+ + + +A D ELQ + K + E +R
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQL-------QAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK 184
++ K+ E ++ EE+ + E + RE +E+IR ++ ++ EE +KE+K
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMR---RQEEMMWEKEEK 350
Query: 185 YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+ +++ +K E + E + + E+ I +LE+K+
Sbjct: 351 MRRQEEMMWEK----EEKMRRLEEMMWEKEEKIRELEEKM 386
Score = 28.5 bits (62), Expect = 5.7
Identities = 15/86 (17%), Positives = 41/86 (47%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I K KI+ +++ + EE+ + ++ + + E ++ ++Q EE++ R
Sbjct: 580 IREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Query: 67 QERLATALQKLEEAEKAADESERGMK 92
+E++ +L + E+ E + ++
Sbjct: 640 EEKMWEQEVRLRQQEEKMQEHQEHLE 665
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 71.6 bits (174), Expect = 6e-13
Identities = 51/220 (23%), Positives = 110/220 (50%), Gaps = 4/220 (1%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E + R+ + +++Q + E + ++E E R++ E ++ +I+ EE++ R +
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE 590
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E++ +K +E E+ + E ++ E + + EEK+ QE +++E + + +E + K
Sbjct: 591 EKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMG 650
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEE 187
E K+ E ++ EE E + RE +++IR +Q K E Q+E +E+
Sbjct: 651 EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIR--EQEEKIREQEEMMQEQEEKMWEQ 708
Query: 188 EIKIL--TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLK 225
E K+ +K++E E + E + + E + E+K++
Sbjct: 709 EEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 70.9 bits (172), Expect = 1e-12
Identities = 58/229 (25%), Positives = 115/229 (50%), Gaps = 12/229 (5%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEA--EVASLNRRIQLVEEELDR 65
E V R+ + +++Q + E+ E++ R+ E + REQ E E ++ + ++ EEE +
Sbjct: 510 EKVWRQEEKIREQEEKIREQEEKMWRQ---EEKIREQEEMWREEEKMHEQEKIWEEEKRQ 566
Query: 66 AQE-RLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADR 124
QE ++ +K+ E E+ E ++ E + + EEKM QE +++E + +E +
Sbjct: 567 EQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEE 626
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDK 184
K E K I E T+E+ E + +M EQ M + + + EEK ++E K
Sbjct: 627 KIREQEEK---IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKK 683
Query: 185 ---YEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
EE+I+ + ++E E + E + + E+ + + E+K++ +E+
Sbjct: 684 IREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Score = 65.1 bits (157), Expect = 5e-11
Identities = 47/227 (20%), Positives = 112/227 (49%), Gaps = 22/227 (9%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E ++ + + +Q E+ +R + E E+ R++ EA++ +I+ EE++ +
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 450
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
+++ +K+ E EK +E +R +++E+M QE ++ E + I + ++ +E
Sbjct: 451 KKMWRQEEKIHEQEKIREEEKR----------QEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNL----KCLSAAEEKYSQKED 183
+ E + + EE+ E + RE +E+IR ++ + + + EE + ++E
Sbjct: 501 Q--------EEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 184 KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEE 230
+E+E +K +E E + E + + E+ + E+K++ +E+
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK 599
Score = 62.8 bits (151), Expect = 3e-10
Identities = 53/216 (24%), Positives = 113/216 (52%), Gaps = 21/216 (9%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGER-RAREQAEAEVASLNRRIQLVEEELDRAQER 69
+ KI+ L+++ + E+ E+ ++ E E+ R +E+ + + A + R+ EE++ +E+
Sbjct: 390 EEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQ----EEKIREQEEK 445
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
+ +K+ E+ E E K+ E +++E+M QE ++ E + I + ++ +E+
Sbjct: 446 IREQEKKMWRQEEKIHEQE---KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ- 501
Query: 130 ARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEI 189
E + + EE+ E + RE +E+IR ++ + EEK ++E+ + EE
Sbjct: 502 -------EEKIRKQEEKVWRQEEKIREQEEKIREQEEK---MWRQEEKIREQEEMWREEE 551
Query: 190 KI-LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
K+ +K+ E E R E E + + E+ I + E+K+
Sbjct: 552 KMHEQEKIWEEEKRQE-QEDKMWRQEEKIREQEEKV 586
Score = 62.4 bits (150), Expect = 4e-10
Identities = 51/239 (21%), Positives = 118/239 (49%), Gaps = 22/239 (9%)
Query: 11 KRKIQVLQQQADDAEERAERLQREVEGERRAREQAEA-EVASLNRRIQLV--EEELDRAQ 67
+ KI+ +++ + E++ R + ++ + + RE+ + E + R+ + + +EE+ R +
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E++ +K+ + E+ E ++ E + + EEKM QE +++E + + E ++ +E
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555
Query: 128 -----------EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEE 176
E K+ E + EE+ E + RE +E+ + ++ + EE
Sbjct: 556 QEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK---MWKQEE 612
Query: 177 KYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQ 235
K ++E+K +E+ +K++E E + E + E+ + + E+K+ C +EE + Q
Sbjct: 613 KIREQEEKIQEQ----EEKIREQEEKIREQEEMTQEQEEKMGEQEEKM-CEQEEKMQEQ 666
Score = 61.6 bits (148), Expect = 6e-10
Identities = 61/241 (25%), Positives = 112/241 (46%), Gaps = 32/241 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
QQQ + + E++Q E E + +EQ E ++ +I+ EE++ R +E + +K+
Sbjct: 296 QQQEEKMWRQEEKIQ---EWEEKIQEQEE-KIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQE---------IQLKEAKHIAEEADRKYEE 128
E+ E E M+ E + EEKM QE I+ E K +E R+ EE
Sbjct: 352 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE 411
Query: 129 VARKLVIIEGDLERTEERAEL--AESRCREMDEQIRLMDQNL---------KCLSAAEEK 177
++ I +R E+ A++ E + RE +E+IR ++ + + EEK
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471
Query: 178 YSQKEDKYEEEIKI--------LTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++E+ + +E KI +K+ E E + E V + E+ I + E+K++ +E
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531
Query: 230 E 230
+
Sbjct: 532 K 532
Score = 61.2 bits (147), Expect = 8e-10
Identities = 58/227 (25%), Positives = 111/227 (48%), Gaps = 23/227 (10%)
Query: 7 IEAVKRKIQ----VLQQQADDAEERAERLQREVEGERRAREQAEAEVASL-NRRIQLVEE 61
++ +KRK++ +L QQ AE A+ L +E++ A+ QA+ E L NR Q EE
Sbjct: 244 VKELKRKLERAKLLLPQQQLQAE--ADHLGKELQSVS-AKLQAQVEENELWNRLNQQQEE 300
Query: 62 ELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEE 121
++ R +E++ +K++E E+ E E ++ E + + EE M +E +++ + + E
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWE 360
Query: 122 ADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQI----RLMDQNLKCLSAAEEK 177
+ K + E + R EE E + RE++E++ ++ +Q K EEK
Sbjct: 361 KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK--RQEEEK 418
Query: 178 YSQKEDKYEEEIKI---------LTDKLKEAETRAEFAERSVAKLEK 215
++E + E+E K+ +K++E E + E + + EK
Sbjct: 419 IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEK 465
Score = 59.7 bits (143), Expect = 2e-09
Identities = 40/183 (21%), Positives = 86/183 (46%), Gaps = 9/183 (4%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ + EE+ R + ++ + R++ E ++ +I+ EE++ +E++ +K+
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIE 137
E E+ E E M + EEKM QE +++E + + K E +K+ E
Sbjct: 636 REQEEMTQEQEEKMG-------EQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 138 GDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLK 197
+ EE + E + E +E ++ +Q K E+ Q+E +E+E+++ + K
Sbjct: 689 EKIREQEEMMQEQEEKMWEQEE--KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEK 746
Query: 198 EAE 200
E
Sbjct: 747 MQE 749
Score = 55.8 bits (133), Expect = 3e-08
Identities = 42/173 (24%), Positives = 86/173 (49%), Gaps = 7/173 (4%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQ 67
E V R+ + +++Q + +E+ E++ ++ E + REQ E ++ +I+ EE++ +
Sbjct: 584 EKVWRQEEKIREQEEKRQEQEEKMWKQ---EEKIREQEE-KIQEQEEKIREQEEKIREQE 639
Query: 68 ERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYE 127
E +K+ E E+ E E M+ E + EEK+ QE +++E + E + +
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQ 699
Query: 128 EVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQ 180
E K+ E + EE+ + E + R +E ++ +Q ++ L EEK +
Sbjct: 700 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE--KMWEQEVR-LRQQEEKMQE 749
Score = 55.5 bits (132), Expect = 4e-08
Identities = 56/248 (22%), Positives = 117/248 (47%), Gaps = 21/248 (8%)
Query: 12 RKIQVLQQQADDAEERAERLQREV-EGERRAREQAEAEVASLNRRIQLVEEELDRAQERL 70
R+ + + +Q EE + Q E+ E + EQ E + ++ EE++ + +E++
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEE--IWRQKEKMHEQEEKIRKQEEKV 512
Query: 71 ATALQKLEEAEKAADESERGM-----KVIENRAL-KDEEKMELQEIQLKEAKHIAEE--- 121
+K+ E E+ E E M K+ E + ++EEKM QE +E K +E
Sbjct: 513 WRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKM 572
Query: 122 --ADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNL----KCLSAAE 175
+ K E K+ E + EE+ + E + + +E+IR ++ + + + E
Sbjct: 573 WRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632
Query: 176 EKYSQKED---KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHL 232
EK ++E+ + EE++ +K+ E E + + E ++ + E+ I + E K++ +E+
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 233 CTQRMLDQ 240
+ M+ +
Sbjct: 693 EQEEMMQE 700
Score = 53.9 bits (128), Expect = 1e-07
Identities = 49/227 (21%), Positives = 103/227 (45%), Gaps = 16/227 (7%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ AV + + + ++ + + L E+ E+ + + A L ++QLVE E
Sbjct: 181 LSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEI 240
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA--DR 124
Q + +KLE A+ + + +A D ELQ + K + E +R
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQL-------QAEADHLGKELQSVSAKLQAQVEENELWNR 293
Query: 125 KYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLK----CLSAAEEKYSQ 180
++ K+ E ++ EE+ + E + RE +E+IR ++ ++ + EEK +
Sbjct: 294 LNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRR 353
Query: 181 KED---KYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKL 224
+E+ + EE+++ + + E E + E + + E+ I +LE+K+
Sbjct: 354 QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Score = 47.0 bits (110), Expect = 2e-05
Identities = 46/199 (23%), Positives = 93/199 (46%), Gaps = 18/199 (9%)
Query: 43 EQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDE 102
EQA + VA+ ++ EEL + ER A +L+ + E+ K+ E L +
Sbjct: 178 EQALSAVATQKKKADRYIEELTK--ERDALSLELYRNTITDEELKEKNAKLQEKLQLVES 235
Query: 103 EKMELQEIQLKEAKHIAEEA---------DRKYEEVARKLVIIEGDLERTEERAELAESR 153
EK E+Q + +KE K E A + + + ++L + L+ E EL
Sbjct: 236 EKSEIQ-LNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL 294
Query: 154 CREMDEQIRLMDQNLKCLSAAEEKYSQKEDKY---EEEIKILTDKLKEAETRAEFAERSV 210
++ +E++ ++ ++ EEK ++E+K EE+I+ +K++ E E +
Sbjct: 295 NQQQEEKMWRQEEKIQ---EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 211 AKLEKTIDDLEDKLKCTKE 229
+ E+ + + E+K++ +E
Sbjct: 352 RRQEEMMWEKEEKMRRQEE 370
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapiens]
Length = 1478
Score = 71.2 bits (173), Expect = 8e-13
Identities = 71/252 (28%), Positives = 114/252 (45%), Gaps = 42/252 (16%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERL---QREVEGERRAREQAEAEVASLNRRIQLVEE-- 61
++ +R+ + +++AD+A++R E L Q E+ + + E+A+ E A L ++
Sbjct: 846 LQCSEREGALQEERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDT 905
Query: 62 ------------ELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE 109
E +R +E LA A+Q+L++A++AA G++ A +EK LQE
Sbjct: 906 AELGIQVCALTVEKERVEEALACAVQELQDAKEAASREREGLE--RQVAGLQQEKESLQE 963
Query: 110 IQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLK 169
+LK AK A G L + + AE R + + E LK
Sbjct: 964 -KLKAAKAAA------------------GSLPGLQAQLAQAEQRAQSLQEAAHQELNTLK 1004
Query: 170 C-LSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTK 228
LSA Y + EE K L +L+E + + AE +V KL+ T D+ +KL CT
Sbjct: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCT- 1063
Query: 229 EEHL--CTQRML 238
HL C ML
Sbjct: 1064 SNHLAECQAAML 1075
Score = 52.4 bits (124), Expect = 4e-07
Identities = 42/216 (19%), Positives = 98/216 (45%), Gaps = 12/216 (5%)
Query: 25 EERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAA 84
E + L +E+E R + ++ +AS + + +++ D A + +A +
Sbjct: 341 ESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEM 400
Query: 85 DESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEADRKYEEVARKLVIIEGDLE 141
E ++ +E K EE Q QL++ + E+A E + +++ ++ +L
Sbjct: 401 QELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELS 460
Query: 142 RTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAET 201
+ A+ R +E+ ++ L L +++ ++++ E+E++ LT +L
Sbjct: 461 GKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL----- 515
Query: 202 RAEFAERSVAKLEKTIDDLEDKLK--CTKEEHLCTQ 235
+F E +A++ + + DLE++ K ++HL Q
Sbjct: 516 --QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQ 549
Score = 40.8 bits (94), Expect = 0.001
Identities = 46/230 (20%), Positives = 101/230 (43%), Gaps = 8/230 (3%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEE---ELDRAQERLATALQ 75
Q+ + E+ + L+RE Q A++ L + +QL E+ L+R + +A +
Sbjct: 398 QEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE 457
Query: 76 KLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVI 135
+L + AD+ R ++ + EE++ + K+ + E +++ + R+L
Sbjct: 458 ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQF 517
Query: 136 IEGDLERTEER-AELAESRCREMDEQIRLMDQ--NLKCLSAAEEKYSQKEDKYEEEIKIL 192
+E L + + ++L E + + + ++ L Q L+ L+ + E + +
Sbjct: 518 LETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVPV 577
Query: 193 TDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTL 242
L+EA + E +R + E +DD + + +EE R L++ L
Sbjct: 578 NSSLQEAWGKPEEEQRGLQ--EAQLDDTKVQEGSQEEELRQANRELEKEL 625
Score = 40.0 bits (92), Expect = 0.002
Identities = 57/249 (22%), Positives = 110/249 (44%), Gaps = 35/249 (14%)
Query: 8 EAVKRKIQVLQQQADDAEERAER----------LQREV-EGERRAREQAEAEVASLNR-R 55
E ++R++ LQQ+ + +E+ + LQ ++ + E+RA+ EA LN +
Sbjct: 945 EGLERQVAGLQQEKESLQEKLKAAKAAAGSLPGLQAQLAQAEQRAQSLQEAAHQELNTLK 1004
Query: 56 IQLVEEELD------RAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQE 109
QL E +D A E + +LEE + +E ++ ++ EK+
Sbjct: 1005 FQLSAEIMDYQSRLKNAGEECKSLRGQLEEQGRQLQAAEEAVEKLKATQADMGEKLSCTS 1064
Query: 110 IQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCRE----MDEQIRLMD 165
L E + D++ + DLERT++ E A ++ +E + +++ +
Sbjct: 1065 NHLAECQAAMLRKDKEG-------AALREDLERTQKELEKATTKIQEYYNKLCQEVTNRE 1117
Query: 166 QN-LKCLSAAEEKYSQKEDKYEEEIKILTDK--LKEAETRAEFAERSVAKLEKTIDDLED 222
+N K L+ ++ K+ E I++L DK L + EF ++ A+ E+ + D E
Sbjct: 1118 RNDQKMLADLDDLNRTKKYLEERLIELLRDKDALWQKSDALEFQQKLSAE-ERWLGDTEA 1176
Query: 223 K--LKCTKE 229
L C +E
Sbjct: 1177 NHCLDCKRE 1185
Score = 36.2 bits (82), Expect = 0.027
Identities = 43/237 (18%), Positives = 97/237 (40%), Gaps = 28/237 (11%)
Query: 36 EGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIE 95
E E+R ++A+ + + Q EEEL +A L LQ + + + + ++ +
Sbjct: 589 EEEQRGLQEAQLDDTKVQEGSQ--EEELRQANRELEKELQNVVGRNQLLEGKLQALQA-D 645
Query: 96 NRALKDEEKM---ELQEIQLKEA--KHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
+AL+ E L ++ ++A +H+ ++ + V + ++ + E +
Sbjct: 646 YQALQQRESAIQGSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEKEAILQSK 705
Query: 151 ESRCREMDEQI----RLMDQNLKCLSAAEEKYSQKEDKYE----------------EEIK 190
E C+++ E++ +L + + L A E + Q+ E E +
Sbjct: 706 EGECQQLREEVEQCQQLAEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEAR 765
Query: 191 ILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDLNE 247
L +L ++ + E + V +L+ + DL+ K++ ++ Q L L E
Sbjct: 766 ELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLRE 822
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 70.9 bits (172), Expect = 1e-12
Identities = 68/251 (27%), Positives = 114/251 (45%), Gaps = 26/251 (10%)
Query: 13 KIQVLQQQADDAEERAE----RLQREVEG-----------ERRAREQAEAEVASLNRRIQ 57
K++ LQ + + + E +LQ EVE E R REQ E + R++
Sbjct: 158 KVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEE-RLREQEERLR 216
Query: 58 LVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKH 117
EE L +ERL ++L E E+ E E ++ E R + EE++ QE +L+E +
Sbjct: 217 EQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEE 276
Query: 118 IAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEK 177
E + + E +L E L EER E R E +E++R ++ L +EK
Sbjct: 277 RLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERLREQEERL----CEQEK 332
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRM 237
+E EE +KL E E R E ER + + E+ ++++E+ L+ + +
Sbjct: 333 LPGQERLLEE-----VEKLLEQERRQEEQERLLER-ERLLEEVEELLEQERLRQQDERLW 386
Query: 238 LDQTLLDLNEM 248
+TL +L +
Sbjct: 387 QQETLQELERL 397
Score = 62.0 bits (149), Expect = 5e-10
Identities = 57/203 (28%), Positives = 95/203 (46%), Gaps = 8/203 (3%)
Query: 8 EAVKRKIQVLQQQADDAEERAERL----QREVEGERRAREQAEAEVASLNRRIQLVEEEL 63
E ++ + + L++Q + E+ ERL +R E E R REQ E + R++ EE L
Sbjct: 199 ERLREQEERLREQEERLREQEERLCEQEERLREQEERLREQEE-RLCEQEERLREHEERL 257
Query: 64 DRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEAD 123
+ERL ++L E E+ E E + E R + EE++ QE +L+E + E +
Sbjct: 258 CEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQE 317
Query: 124 RKYEEVARKLVIIE--GDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQK 181
+ E +L E ER E E + R +EQ RL+++ + L EE Q+
Sbjct: 318 ERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERE-RLLEEVEELLEQE 376
Query: 182 EDKYEEEIKILTDKLKEAETRAE 204
+ ++E + L+E E E
Sbjct: 377 RLRQQDERLWQQETLQELERLRE 399
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 69.3 bits (168), Expect = 3e-12
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLE-RTEERAELAESR---CREMDEQIRLMDQNLKCLSA 173
+ A +R +E + + + E R +++AE +R RE++ ++ L+
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AEE QK E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1708 RLAAEQEL 1715
Score = 64.7 bits (156), Expect = 7e-11
Identities = 60/240 (25%), Positives = 109/240 (45%), Gaps = 35/240 (14%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKY 178
AE+ R+ +V ++L + LE T D Q L+D+ L+ L A +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEA 2219
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKT-----IDDLEDKLKCTKEE 230
+++ + EEE +++ ++L + + R E R++ +K + + +K+K EE
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Score = 63.2 bits (152), Expect = 2e-10
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + + EM Q
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEM--QTVQ 2480
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+Q L+ A ++ + ++D + R F E+ AKLE+ D K
Sbjct: 2481 QEQLLQETQALQQSFLSEKDSLLQ--------------RERFIEQEKAKLEQLFQDEVAK 2526
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2527 AQQLREEQQRQQQQMEQ 2543
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/254 (21%), Positives = 116/254 (45%), Gaps = 40/254 (15%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADE-------SERGMKVIENRALK---------------- 100
ERL A+ +LE E EK E SE V + + L+
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 101 -------DEEKMELQEI---QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
++EK +L+++ ++ +A+ + EE R+ +++ ++ + +E R A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 151 ESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSV 210
E R E+++ ++Q + EE +++ + E++++L ++ + A +E S
Sbjct: 2563 EEGVRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 211 AKLEKTIDDLEDKL 224
KT+ + D L
Sbjct: 2620 VAATKTLPNGRDAL 2633
Score = 56.2 bits (134), Expect = 3e-08
Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1839
Query: 134 VIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A +E++R + A +E + ++ + EE+
Sbjct: 1840 AAI-GEATRLKTEAEIALKEKEAENERLRRL--------AEDEAFQRR--RLEEQ----- 1883
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1884 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1930
Score = 55.8 bits (133), Expect = 3e-08
Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAE-SRCREMDEQIRLMDQNLKC-----LSAAEEKYSQKED 183
+ L + E E R AE R R++ + ++ + ++ EK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 52.8 bits (125), Expect = 3e-07
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 22/202 (10%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEV------ASLNRRIQLVEEELDRAQERLAT 72
Q ++AE RA Q++ E E RARE+AE E+ A+ R++L EE+ + Q+ LA
Sbjct: 1605 QLREEAERRA---QQQAEAE-RAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQ 1659
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
A EAEK +E+ER + + + EL E +L++ + +AE ++ ++
Sbjct: 1660 A-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
L+ + + E+ E++ +L E + + Q + L A K + E E+ +L
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-LL 1768
Query: 193 TDKLKEAETRAEFAERSVAKLE 214
K + E +E+S +LE
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLE 1790
Score = 52.8 bits (125), Expect = 3e-07
Identities = 57/255 (22%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + R + E M Q L +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 174 AEEKYSQKEDKYEEEIKILTDKLK----EAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++ + E + + E+ ++LK E AE + K +++ +KL T+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE- 2421
Query: 230 EHLCTQR--MLDQTL 242
L TQ L QTL
Sbjct: 2422 --LATQEKVTLVQTL 2434
Score = 52.4 bits (124), Expect = 4e-07
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESRCR-EMDEQIRLMDQNLKCLSAAEEK 177
+K EE A + E +L++T ++ + + R E + R ++ + AE +
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
+Q + EE ++ ++A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 52.4 bits (124), Expect = 4e-07
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R E
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------- 2091
Query: 136 IEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDK 195
E + R + E A+SR R+++E RL +AEE+ + K+ +
Sbjct: 2092 -EAEEARVQAEREAAQSR-RQVEEAERLK-------QSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2143 EQEAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Score = 52.0 bits (123), Expect = 5e-07
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 21/220 (9%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQN 167
+QL+ + A+ + + + + E + +E AE + ++ ++ R +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L AE + ++++ + + ++ L + +EAE R AE
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Score = 51.6 bits (122), Expect = 6e-07
Identities = 50/226 (22%), Positives = 109/226 (48%), Gaps = 11/226 (4%)
Query: 2 AGITTIEAVKRKIQVLQQQADDAE-ERAERLQREVE-GERRAREQAEAEVASLNRRIQLV 59
A + +E +K K++ ++ + AE E A +LQ E ++R + + +A ++ ++ Q +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 60 EEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
++ L + Q L + E A +AA+E+E E A + ++E E +LK++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQ 2124
Query: 120 EEADRKYEEVARKL---VIIEGDLERTEERAELAESRC--REMDEQIRLMDQNLKCLSAA 174
+A + + A KL E E+A L + + EM++ + +Q L+ +
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 175 EEKYSQKEDKYEE---EIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E++ + + EE + +L ++L+ + A A R +++E+ +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Score = 48.5 bits (114), Expect = 5e-06
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 48/251 (19%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAE----LAESRCREMDEQIRLMDQNLKCLSAAEEK- 177
EE AR+ ++ER + + E L E +E Q++L + + AEEK
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 178 ----YSQKEDKYEEEI---KILTDKLK-----------EAETRAEFAERSVAKLEKTIDD 219
QKE + ++ + + + D+L+ EAE AER A+ + +++
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 220 LEDKLKCTKEE 230
E +LK + EE
Sbjct: 2114 AE-RLKQSAEE 2123
Score = 38.9 bits (89), Expect = 0.004
Identities = 56/260 (21%), Positives = 111/260 (42%), Gaps = 45/260 (17%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE 145
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 146 RAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF 205
A+ + + + E + +L+ YS+ + IK +++ L+ E
Sbjct: 1299 PAK--KPKVQSGSESVIQEYVDLR------THYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 206 AERSVAKLEKTIDDLEDKLK 225
AE+ A+ + + ++E L+
Sbjct: 1351 AEQQRAEERERLAEVEAALE 1370
Score = 31.2 bits (69), Expect = 0.88
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 8/119 (6%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEE R Q E++ + R Q E +A N+R++ E+L +E+ AL
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHS 2612
Query: 78 EE---AEKAADES-ERGMKVIENRALKDEEKMELQEIQLK-EAKHIAEEADRKYEEVAR 131
EE ++ AA ++ G ++ A + E + ++ K A+ + E EE+ R
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/121 (22%), Positives = 58/121 (47%), Gaps = 16/121 (13%)
Query: 7 IEAVKRKIQVLQQ----QADDAEERAERLQREVEGERR----AREQAEAEVASLNRRIQL 58
IE K K++ L Q +A E +R Q+++E ER+ + E+A ++
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 59 VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
+EEL + ++ Q+ ++ E A+E++R + ++ L+++ + L + A +
Sbjct: 2569 KQEELQQLEQ------QRRQQEELLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2620
Query: 119 A 119
A
Sbjct: 2621 A 2621
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 69.3 bits (168), Expect = 3e-12
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1532
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1533 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1591
Query: 120 EEA--DRKYEEVARKLVIIEGDLE-RTEERAELAESR---CREMDEQIRLMDQNLKCLSA 173
+ A +R +E + + + E R +++AE +R RE++ ++ L+
Sbjct: 1592 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1651
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AEE QK E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1712 RLAAEQEL 1719
Score = 64.7 bits (156), Expect = 7e-11
Identities = 60/240 (25%), Positives = 109/240 (45%), Gaps = 35/240 (14%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2061 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2120
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2121 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2177
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKY 178
AE+ R+ +V ++L + LE T D Q L+D+ L+ L A +
Sbjct: 2178 AEQTLRQKAQVEQELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEA 2223
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKT-----IDDLEDKLKCTKEE 230
+++ + EEE +++ ++L + + R E R++ +K + + +K+K EE
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Score = 63.2 bits (152), Expect = 2e-10
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2433
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + + EM Q
Sbjct: 2434 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEM--QTVQ 2484
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+Q L+ A ++ + ++D + R F E+ AKLE+ D K
Sbjct: 2485 QEQLLQETQALQQSFLSEKDSLLQ--------------RERFIEQEKAKLEQLFQDEVAK 2530
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2531 AQQLREEQQRQQQQMEQ 2547
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/254 (21%), Positives = 116/254 (45%), Gaps = 40/254 (15%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2387 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2446
Query: 65 RAQERLATALQKLE-EAEKAADE-------SERGMKVIENRALK---------------- 100
ERL A+ +LE E EK E SE V + + L+
Sbjct: 2447 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2506
Query: 101 -------DEEKMELQEI---QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
++EK +L+++ ++ +A+ + EE R+ +++ ++ + +E R A
Sbjct: 2507 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2566
Query: 151 ESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSV 210
E R E+++ ++Q + EE +++ + E++++L ++ + A +E S
Sbjct: 2567 EEGVRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2623
Query: 211 AKLEKTIDDLEDKL 224
KT+ + D L
Sbjct: 2624 VAATKTLPNGRDAL 2637
Score = 56.2 bits (134), Expect = 3e-08
Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1730 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1789
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1790 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1843
Query: 134 VIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A +E++R + A +E + ++ + EE+
Sbjct: 1844 AAI-GEATRLKTEAEIALKEKEAENERLRRL--------AEDEAFQRR--RLEEQ----- 1887
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1888 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1934
Score = 55.8 bits (133), Expect = 3e-08
Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1419 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 130 ARKLVIIEGDLERTEERAELAE-SRCREMDEQIRLMDQNLKC-----LSAAEEKYSQKED 183
+ L + E E R AE R R++ + ++ + ++ EK +Q E
Sbjct: 1539 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1598
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1599 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1636
Score = 52.8 bits (125), Expect = 3e-07
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 22/202 (10%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEV------ASLNRRIQLVEEELDRAQERLAT 72
Q ++AE RA Q++ E E RARE+AE E+ A+ R++L EE+ + Q+ LA
Sbjct: 1609 QLREEAERRA---QQQAEAE-RAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQ 1663
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
A EAEK +E+ER + + + EL E +L++ + +AE ++ ++
Sbjct: 1664 A-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1718
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
L+ + + E+ E++ +L E + + Q + L A K + E E+ +L
Sbjct: 1719 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-LL 1772
Query: 193 TDKLKEAETRAEFAERSVAKLE 214
K + E +E+S +LE
Sbjct: 1773 ASKARAEEESRSTSEKSKQRLE 1794
Score = 52.8 bits (125), Expect = 3e-07
Identities = 57/255 (22%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2192 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2247
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2248 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2306
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + R + E M Q L +
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 174 AEEKYSQKEDKYEEEIKILTDKLK----EAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++ + E + + E+ ++LK E AE + K +++ +KL T+
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE- 2425
Query: 230 EHLCTQR--MLDQTL 242
L TQ L QTL
Sbjct: 2426 --LATQEKVTLVQTL 2438
Score = 52.4 bits (124), Expect = 4e-07
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1931 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1987
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1988 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2047
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESRCR-EMDEQIRLMDQNLKCLSAAEEK 177
+K EE A + E +L++T ++ + + R E + R ++ + AE +
Sbjct: 2048 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2107
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
+Q + EE ++ ++A+ RA+ A+ + KL K
Sbjct: 2108 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2144
Score = 52.4 bits (124), Expect = 4e-07
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1984 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2043
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R E
Sbjct: 2044 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------- 2095
Query: 136 IEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDK 195
E + R + E A+SR R+++E RL +AEE+ + K+ +
Sbjct: 2096 -EAEEARVQAEREAAQSR-RQVEEAERLK-------QSAEEQAQARAQAQAAAEKLRKEA 2146
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2147 EQEAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2195
Score = 52.0 bits (123), Expect = 5e-07
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 21/220 (9%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1344 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1402
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1403 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1460
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQN 167
+QL+ + A+ + + + + E + +E AE + ++ ++ R +
Sbjct: 1461 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1520
Query: 168 LKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L AE + ++++ + + ++ L + +EAE R AE
Sbjct: 1521 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1560
Score = 51.6 bits (122), Expect = 6e-07
Identities = 50/226 (22%), Positives = 109/226 (48%), Gaps = 11/226 (4%)
Query: 2 AGITTIEAVKRKIQVLQQQADDAE-ERAERLQREVE-GERRAREQAEAEVASLNRRIQLV 59
A + +E +K K++ ++ + AE E A +LQ E ++R + + +A ++ ++ Q +
Sbjct: 2010 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2069
Query: 60 EEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
++ L + Q L + E A +AA+E+E E A + ++E E +LK++
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQ 2128
Query: 120 EEADRKYEEVARKL---VIIEGDLERTEERAELAESRC--REMDEQIRLMDQNLKCLSAA 174
+A + + A KL E E+A L + + EM++ + +Q L+ +
Sbjct: 2129 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2188
Query: 175 EEKYSQKEDKYEE---EIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E++ + + EE + +L ++L+ + A A R +++E+ +
Sbjct: 2189 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2234
Score = 48.5 bits (114), Expect = 5e-06
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 48/251 (19%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1895 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1951
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1952 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2001
Query: 123 DRKYEEVARKLVIIEGDLERTEERAE----LAESRCREMDEQIRLMDQNLKCLSAAEEK- 177
EE AR+ ++ER + + E L E +E Q++L + + AEEK
Sbjct: 2002 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 178 ----YSQKEDKYEEEI---KILTDKLK-----------EAETRAEFAERSVAKLEKTIDD 219
QKE + ++ + + + D+L+ EAE AER A+ + +++
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 220 LEDKLKCTKEE 230
E +LK + EE
Sbjct: 2118 AE-RLKQSAEE 2127
Score = 38.9 bits (89), Expect = 0.004
Identities = 56/260 (21%), Positives = 111/260 (42%), Gaps = 45/260 (17%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1124 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1182
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1183 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1242
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE 145
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1243 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1302
Query: 146 RAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF 205
A+ + + + E + +L+ YS+ + IK +++ L+ E
Sbjct: 1303 PAK--KPKVQSGSESVIQEYVDLR------THYSELTTLTSQYIKFISETLRRMEEEERL 1354
Query: 206 AERSVAKLEKTIDDLEDKLK 225
AE+ A+ + + ++E L+
Sbjct: 1355 AEQQRAEERERLAEVEAALE 1374
Score = 31.2 bits (69), Expect = 0.88
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 8/119 (6%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEE R Q E++ + R Q E +A N+R++ E+L +E+ AL
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHS 2616
Query: 78 EE---AEKAADES-ERGMKVIENRALKDEEKMELQEIQLK-EAKHIAEEADRKYEEVAR 131
EE ++ AA ++ G ++ A + E + ++ K A+ + E EE+ R
Sbjct: 2617 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2675
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/121 (22%), Positives = 58/121 (47%), Gaps = 16/121 (13%)
Query: 7 IEAVKRKIQVLQQ----QADDAEERAERLQREVEGERR----AREQAEAEVASLNRRIQL 58
IE K K++ L Q +A E +R Q+++E ER+ + E+A ++
Sbjct: 2513 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2572
Query: 59 VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
+EEL + ++ Q+ ++ E A+E++R + ++ L+++ + L + A +
Sbjct: 2573 KQEELQQLEQ------QRRQQEELLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2624
Query: 119 A 119
A
Sbjct: 2625 A 2625
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 69.3 bits (168), Expect = 3e-12
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1528
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1529 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1587
Query: 120 EEA--DRKYEEVARKLVIIEGDLE-RTEERAELAESR---CREMDEQIRLMDQNLKCLSA 173
+ A +R +E + + + E R +++AE +R RE++ ++ L+
Sbjct: 1588 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1647
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AEE QK E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1708 RLAAEQEL 1715
Score = 64.7 bits (156), Expect = 7e-11
Identities = 60/240 (25%), Positives = 109/240 (45%), Gaps = 35/240 (14%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2057 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2116
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2117 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2173
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKY 178
AE+ R+ +V ++L + LE T D Q L+D+ L+ L A +
Sbjct: 2174 AEQTLRQKAQVEQELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEA 2219
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKT-----IDDLEDKLKCTKEE 230
+++ + EEE +++ ++L + + R E R++ +K + + +K+K EE
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Score = 63.2 bits (152), Expect = 2e-10
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2429
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + + EM Q
Sbjct: 2430 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEM--QTVQ 2480
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+Q L+ A ++ + ++D + R F E+ AKLE+ D K
Sbjct: 2481 QEQLLQETQALQQSFLSEKDSLLQ--------------RERFIEQEKAKLEQLFQDEVAK 2526
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2527 AQQLREEQQRQQQQMEQ 2543
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/254 (21%), Positives = 116/254 (45%), Gaps = 40/254 (15%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2383 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2442
Query: 65 RAQERLATALQKLE-EAEKAADE-------SERGMKVIENRALK---------------- 100
ERL A+ +LE E EK E SE V + + L+
Sbjct: 2443 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2502
Query: 101 -------DEEKMELQEI---QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
++EK +L+++ ++ +A+ + EE R+ +++ ++ + +E R A
Sbjct: 2503 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2562
Query: 151 ESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSV 210
E R E+++ ++Q + EE +++ + E++++L ++ + A +E S
Sbjct: 2563 EEGVRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2619
Query: 211 AKLEKTIDDLEDKL 224
KT+ + D L
Sbjct: 2620 VAATKTLPNGRDAL 2633
Score = 56.2 bits (134), Expect = 3e-08
Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1726 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1785
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1786 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1839
Query: 134 VIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A +E++R + A +E + ++ + EE+
Sbjct: 1840 AAI-GEATRLKTEAEIALKEKEAENERLRRL--------AEDEAFQRR--RLEEQ----- 1883
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1884 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1930
Score = 55.8 bits (133), Expect = 3e-08
Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1415 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 130 ARKLVIIEGDLERTEERAELAE-SRCREMDEQIRLMDQNLKC-----LSAAEEKYSQKED 183
+ L + E E R AE R R++ + ++ + ++ EK +Q E
Sbjct: 1535 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1594
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1595 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1632
Score = 52.8 bits (125), Expect = 3e-07
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 22/202 (10%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEV------ASLNRRIQLVEEELDRAQERLAT 72
Q ++AE RA Q++ E E RARE+AE E+ A+ R++L EE+ + Q+ LA
Sbjct: 1605 QLREEAERRA---QQQAEAE-RAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQ 1659
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
A EAEK +E+ER + + + EL E +L++ + +AE ++ ++
Sbjct: 1660 A-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1714
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
L+ + + E+ E++ +L E + + Q + L A K + E E+ +L
Sbjct: 1715 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-LL 1768
Query: 193 TDKLKEAETRAEFAERSVAKLE 214
K + E +E+S +LE
Sbjct: 1769 ASKARAEEESRSTSEKSKQRLE 1790
Score = 52.8 bits (125), Expect = 3e-07
Identities = 57/255 (22%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2188 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2243
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2244 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2302
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + R + E M Q L +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 174 AEEKYSQKEDKYEEEIKILTDKLK----EAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++ + E + + E+ ++LK E AE + K +++ +KL T+
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE- 2421
Query: 230 EHLCTQR--MLDQTL 242
L TQ L QTL
Sbjct: 2422 --LATQEKVTLVQTL 2434
Score = 52.4 bits (124), Expect = 4e-07
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1927 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1983
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1984 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2043
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESRCR-EMDEQIRLMDQNLKCLSAAEEK 177
+K EE A + E +L++T ++ + + R E + R ++ + AE +
Sbjct: 2044 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2103
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
+Q + EE ++ ++A+ RA+ A+ + KL K
Sbjct: 2104 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2140
Score = 52.4 bits (124), Expect = 4e-07
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1980 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2039
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R E
Sbjct: 2040 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------- 2091
Query: 136 IEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDK 195
E + R + E A+SR R+++E RL +AEE+ + K+ +
Sbjct: 2092 -EAEEARVQAEREAAQSR-RQVEEAERLK-------QSAEEQAQARAQAQAAAEKLRKEA 2142
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2143 EQEAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2191
Score = 52.0 bits (123), Expect = 5e-07
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 21/220 (9%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1340 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1398
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1399 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1456
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQN 167
+QL+ + A+ + + + + E + +E AE + ++ ++ R +
Sbjct: 1457 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1516
Query: 168 LKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L AE + ++++ + + ++ L + +EAE R AE
Sbjct: 1517 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1556
Score = 51.6 bits (122), Expect = 6e-07
Identities = 50/226 (22%), Positives = 109/226 (48%), Gaps = 11/226 (4%)
Query: 2 AGITTIEAVKRKIQVLQQQADDAE-ERAERLQREVE-GERRAREQAEAEVASLNRRIQLV 59
A + +E +K K++ ++ + AE E A +LQ E ++R + + +A ++ ++ Q +
Sbjct: 2006 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2065
Query: 60 EEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
++ L + Q L + E A +AA+E+E E A + ++E E +LK++
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQ 2124
Query: 120 EEADRKYEEVARKL---VIIEGDLERTEERAELAESRC--REMDEQIRLMDQNLKCLSAA 174
+A + + A KL E E+A L + + EM++ + +Q L+ +
Sbjct: 2125 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2184
Query: 175 EEKYSQKEDKYEE---EIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E++ + + EE + +L ++L+ + A A R +++E+ +
Sbjct: 2185 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2230
Score = 48.5 bits (114), Expect = 5e-06
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 48/251 (19%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1891 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1947
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1948 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1997
Query: 123 DRKYEEVARKLVIIEGDLERTEERAE----LAESRCREMDEQIRLMDQNLKCLSAAEEK- 177
EE AR+ ++ER + + E L E +E Q++L + + AEEK
Sbjct: 1998 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 178 ----YSQKEDKYEEEI---KILTDKLK-----------EAETRAEFAERSVAKLEKTIDD 219
QKE + ++ + + + D+L+ EAE AER A+ + +++
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 220 LEDKLKCTKEE 230
E +LK + EE
Sbjct: 2114 AE-RLKQSAEE 2123
Score = 38.9 bits (89), Expect = 0.004
Identities = 56/260 (21%), Positives = 111/260 (42%), Gaps = 45/260 (17%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1120 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1178
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1179 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1238
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE 145
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1239 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1298
Query: 146 RAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF 205
A+ + + + E + +L+ YS+ + IK +++ L+ E
Sbjct: 1299 PAK--KPKVQSGSESVIQEYVDLR------THYSELTTLTSQYIKFISETLRRMEEEERL 1350
Query: 206 AERSVAKLEKTIDDLEDKLK 225
AE+ A+ + + ++E L+
Sbjct: 1351 AEQQRAEERERLAEVEAALE 1370
Score = 31.2 bits (69), Expect = 0.88
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 8/119 (6%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEE R Q E++ + R Q E +A N+R++ E+L +E+ AL
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHS 2612
Query: 78 EE---AEKAADES-ERGMKVIENRALKDEEKMELQEIQLK-EAKHIAEEADRKYEEVAR 131
EE ++ AA ++ G ++ A + E + ++ K A+ + E EE+ R
Sbjct: 2613 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2671
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/121 (22%), Positives = 58/121 (47%), Gaps = 16/121 (13%)
Query: 7 IEAVKRKIQVLQQ----QADDAEERAERLQREVEGERR----AREQAEAEVASLNRRIQL 58
IE K K++ L Q +A E +R Q+++E ER+ + E+A ++
Sbjct: 2509 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2568
Query: 59 VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
+EEL + ++ Q+ ++ E A+E++R + ++ L+++ + L + A +
Sbjct: 2569 KQEELQQLEQ------QRRQQEELLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2620
Query: 119 A 119
A
Sbjct: 2621 A 2621
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 69.3 bits (168), Expect = 3e-12
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1496
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1497 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1555
Query: 120 EEA--DRKYEEVARKLVIIEGDLE-RTEERAELAESR---CREMDEQIRLMDQNLKCLSA 173
+ A +R +E + + + E R +++AE +R RE++ ++ L+
Sbjct: 1556 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1615
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AEE QK E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1676 RLAAEQEL 1683
Score = 64.7 bits (156), Expect = 7e-11
Identities = 60/240 (25%), Positives = 109/240 (45%), Gaps = 35/240 (14%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2025 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2084
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2085 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2141
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKY 178
AE+ R+ +V ++L + LE T D Q L+D+ L+ L A +
Sbjct: 2142 AEQTLRQKAQVEQELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEA 2187
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKT-----IDDLEDKLKCTKEE 230
+++ + EEE +++ ++L + + R E R++ +K + + +K+K EE
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Score = 63.2 bits (152), Expect = 2e-10
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2397
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + + EM Q
Sbjct: 2398 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEM--QTVQ 2448
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+Q L+ A ++ + ++D + R F E+ AKLE+ D K
Sbjct: 2449 QEQLLQETQALQQSFLSEKDSLLQ--------------RERFIEQEKAKLEQLFQDEVAK 2494
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2495 AQQLREEQQRQQQQMEQ 2511
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/254 (21%), Positives = 116/254 (45%), Gaps = 40/254 (15%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2351 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2410
Query: 65 RAQERLATALQKLE-EAEKAADE-------SERGMKVIENRALK---------------- 100
ERL A+ +LE E EK E SE V + + L+
Sbjct: 2411 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2470
Query: 101 -------DEEKMELQEI---QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
++EK +L+++ ++ +A+ + EE R+ +++ ++ + +E R A
Sbjct: 2471 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2530
Query: 151 ESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSV 210
E R E+++ ++Q + EE +++ + E++++L ++ + A +E S
Sbjct: 2531 EEGVRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2587
Query: 211 AKLEKTIDDLEDKL 224
KT+ + D L
Sbjct: 2588 VAATKTLPNGRDAL 2601
Score = 56.2 bits (134), Expect = 3e-08
Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1694 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1753
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1754 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1807
Query: 134 VIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A +E++R + A +E + ++ + EE+
Sbjct: 1808 AAI-GEATRLKTEAEIALKEKEAENERLRRL--------AEDEAFQRR--RLEEQ----- 1851
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 1852 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 1898
Score = 55.8 bits (133), Expect = 3e-08
Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1383 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 130 ARKLVIIEGDLERTEERAELAE-SRCREMDEQIRLMDQNLKC-----LSAAEEKYSQKED 183
+ L + E E R AE R R++ + ++ + ++ EK +Q E
Sbjct: 1503 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1562
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1563 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1600
Score = 52.8 bits (125), Expect = 3e-07
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 22/202 (10%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEV------ASLNRRIQLVEEELDRAQERLAT 72
Q ++AE RA Q++ E E RARE+AE E+ A+ R++L EE+ + Q+ LA
Sbjct: 1573 QLREEAERRA---QQQAEAE-RAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQ 1627
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
A EAEK +E+ER + + + EL E +L++ + +AE ++ ++
Sbjct: 1628 A-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1682
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
L+ + + E+ E++ +L E + + Q + L A K + E E+ +L
Sbjct: 1683 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-LL 1736
Query: 193 TDKLKEAETRAEFAERSVAKLE 214
K + E +E+S +LE
Sbjct: 1737 ASKARAEEESRSTSEKSKQRLE 1758
Score = 52.8 bits (125), Expect = 3e-07
Identities = 57/255 (22%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2156 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2211
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2212 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2270
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + R + E M Q L +
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 174 AEEKYSQKEDKYEEEIKILTDKLK----EAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++ + E + + E+ ++LK E AE + K +++ +KL T+
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE- 2389
Query: 230 EHLCTQR--MLDQTL 242
L TQ L QTL
Sbjct: 2390 --LATQEKVTLVQTL 2402
Score = 52.4 bits (124), Expect = 4e-07
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 1895 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 1951
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 1952 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2011
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESRCR-EMDEQIRLMDQNLKCLSAAEEK 177
+K EE A + E +L++T ++ + + R E + R ++ + AE +
Sbjct: 2012 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2071
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
+Q + EE ++ ++A+ RA+ A+ + KL K
Sbjct: 2072 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2108
Score = 52.4 bits (124), Expect = 4e-07
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 1948 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2007
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R E
Sbjct: 2008 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------- 2059
Query: 136 IEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDK 195
E + R + E A+SR R+++E RL +AEE+ + K+ +
Sbjct: 2060 -EAEEARVQAEREAAQSR-RQVEEAERLK-------QSAEEQAQARAQAQAAAEKLRKEA 2110
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2111 EQEAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2159
Score = 52.0 bits (123), Expect = 5e-07
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 21/220 (9%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1308 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1366
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1367 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1424
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQN 167
+QL+ + A+ + + + + E + +E AE + ++ ++ R +
Sbjct: 1425 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1484
Query: 168 LKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L AE + ++++ + + ++ L + +EAE R AE
Sbjct: 1485 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1524
Score = 51.6 bits (122), Expect = 6e-07
Identities = 50/226 (22%), Positives = 109/226 (48%), Gaps = 11/226 (4%)
Query: 2 AGITTIEAVKRKIQVLQQQADDAE-ERAERLQREVE-GERRAREQAEAEVASLNRRIQLV 59
A + +E +K K++ ++ + AE E A +LQ E ++R + + +A ++ ++ Q +
Sbjct: 1974 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2033
Query: 60 EEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
++ L + Q L + E A +AA+E+E E A + ++E E +LK++
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQ 2092
Query: 120 EEADRKYEEVARKL---VIIEGDLERTEERAELAESRC--REMDEQIRLMDQNLKCLSAA 174
+A + + A KL E E+A L + + EM++ + +Q L+ +
Sbjct: 2093 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2152
Query: 175 EEKYSQKEDKYEE---EIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E++ + + EE + +L ++L+ + A A R +++E+ +
Sbjct: 2153 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2198
Score = 48.5 bits (114), Expect = 5e-06
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 48/251 (19%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 1859 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1915
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 1916 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 1965
Query: 123 DRKYEEVARKLVIIEGDLERTEERAE----LAESRCREMDEQIRLMDQNLKCLSAAEEK- 177
EE AR+ ++ER + + E L E +E Q++L + + AEEK
Sbjct: 1966 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 178 ----YSQKEDKYEEEI---KILTDKLK-----------EAETRAEFAERSVAKLEKTIDD 219
QKE + ++ + + + D+L+ EAE AER A+ + +++
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 220 LEDKLKCTKEE 230
E +LK + EE
Sbjct: 2082 AE-RLKQSAEE 2091
Score = 38.9 bits (89), Expect = 0.004
Identities = 56/260 (21%), Positives = 111/260 (42%), Gaps = 45/260 (17%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1088 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1146
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1147 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1206
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE 145
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1207 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1266
Query: 146 RAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF 205
A+ + + + E + +L+ YS+ + IK +++ L+ E
Sbjct: 1267 PAK--KPKVQSGSESVIQEYVDLR------THYSELTTLTSQYIKFISETLRRMEEEERL 1318
Query: 206 AERSVAKLEKTIDDLEDKLK 225
AE+ A+ + + ++E L+
Sbjct: 1319 AEQQRAEERERLAEVEAALE 1338
Score = 31.2 bits (69), Expect = 0.88
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 8/119 (6%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEE R Q E++ + R Q E +A N+R++ E+L +E+ AL
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHS 2580
Query: 78 EE---AEKAADES-ERGMKVIENRALKDEEKMELQEIQLK-EAKHIAEEADRKYEEVAR 131
EE ++ AA ++ G ++ A + E + ++ K A+ + E EE+ R
Sbjct: 2581 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2639
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/121 (22%), Positives = 58/121 (47%), Gaps = 16/121 (13%)
Query: 7 IEAVKRKIQVLQQ----QADDAEERAERLQREVEGERR----AREQAEAEVASLNRRIQL 58
IE K K++ L Q +A E +R Q+++E ER+ + E+A ++
Sbjct: 2477 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2536
Query: 59 VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
+EEL + ++ Q+ ++ E A+E++R + ++ L+++ + L + A +
Sbjct: 2537 KQEELQQLEQ------QRRQQEELLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2588
Query: 119 A 119
A
Sbjct: 2589 A 2589
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 69.3 bits (168), Expect = 3e-12
Identities = 67/248 (27%), Positives = 121/248 (48%), Gaps = 23/248 (9%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
++A++ + + + Q A+E AERL+R+V+ E + + QAE E+AS V+ E + A
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS------RVKAEAEAA 1665
Query: 67 QERLATALQKLEEAEKAADESERGMKVIE-------NRALKDEEKMELQEIQLKEAKHIA 119
+E+ ALQ LEE A+E+ER ++ E AL+ ++ E+Q K A
Sbjct: 1666 REK-QRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAE 1724
Query: 120 EEA--DRKYEEVARKLVIIEGDLE-RTEERAELAESR---CREMDEQIRLMDQNLKCLSA 173
+ A +R +E + + + E R +++AE +R RE++ ++ L+
Sbjct: 1725 KTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784
Query: 174 AEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDKLKC---TKEE 230
AEE QK E K + +EA R + E++V + E +LE + + T ++
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844
Query: 231 HLCTQRML 238
L ++ L
Sbjct: 1845 RLAAEQEL 1852
Score = 64.7 bits (156), Expect = 7e-11
Identities = 60/240 (25%), Positives = 109/240 (45%), Gaps = 35/240 (14%)
Query: 9 AVKRKIQVLQQQADDAEERAERLQREVEGERRARE-------QAEAEVASLNRRIQLVEE 61
AV++K Q LQQ + ++L+ E E RRA E QAE E A R+++ E
Sbjct: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253
Query: 62 ELDRAQERLATALQKLEEAEKAADESER---GMKVIENRALKDEEKMELQEIQLKEAKHI 118
A+E+ Q AEK E+E+ E AL+ + + + ++++ K
Sbjct: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK---QAADAEMEKHKKF 2310
Query: 119 AEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKY 178
AE+ R+ +V ++L + LE T D Q L+D+ L+ L A +
Sbjct: 2311 AEQTLRQKAQVEQELTTLRLQLEET--------------DHQKNLLDEELQRLKAEATEA 2356
Query: 179 SQKEDKYEEE---IKILTDKLKEAETRAEFAERSVAKLEKT-----IDDLEDKLKCTKEE 230
+++ + EEE +++ ++L + + R E R++ +K + + +K+K EE
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Score = 63.2 bits (152), Expect = 2e-10
Identities = 64/257 (24%), Positives = 119/257 (46%), Gaps = 46/257 (17%)
Query: 1 MAGITTIEAVKRKIQVLQQQADDAEERAERLQR-----------EVEGERR---AREQAE 46
M + +K + ++LQQQ + A+E+A RLQ E +G +R A Q +
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKME 106
E+++ R++L E+ RAQ R E+A++ ++E + + L +EK+
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVT 2566
Query: 107 LQ---EIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRL 163
L EIQ +++ H +A+R E +A +E + E+ ++ A+L + + EM Q
Sbjct: 2567 LVQTLEIQRQQSDH---DAERLREAIAE----LEREKEKLQQEAKLLQLKSEEM--QTVQ 2617
Query: 164 MDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDK 223
+Q L+ A ++ + ++D + R F E+ AKLE+ D K
Sbjct: 2618 QEQLLQETQALQQSFLSEKDSLLQ--------------RERFIEQEKAKLEQLFQDEVAK 2663
Query: 224 LKCTKEEHLCTQRMLDQ 240
+ +EE Q+ ++Q
Sbjct: 2664 AQQLREEQQRQQQQMEQ 2680
Score = 57.8 bits (138), Expect = 9e-09
Identities = 55/254 (21%), Positives = 116/254 (45%), Gaps = 40/254 (15%)
Query: 8 EAVKRKIQVLQQQADDAEERAERLQREVE--GERRAR-EQAEAEVASLNRRIQLVEEELD 64
E +K ++ + + AEE A+R +++ E GE+ R E A E +L + +++ ++ D
Sbjct: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSD 2579
Query: 65 RAQERLATALQKLE-EAEKAADE-------SERGMKVIENRALK---------------- 100
ERL A+ +LE E EK E SE V + + L+
Sbjct: 2580 HDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639
Query: 101 -------DEEKMELQEI---QLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELA 150
++EK +L+++ ++ +A+ + EE R+ +++ ++ + +E R A
Sbjct: 2640 LQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEA 2699
Query: 151 ESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSV 210
E R E+++ ++Q + EE +++ + E++++L ++ + A +E S
Sbjct: 2700 EEGVRRKQEELQQLEQQRR---QQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQ 2756
Query: 211 AKLEKTIDDLEDKL 224
KT+ + D L
Sbjct: 2757 VAATKTLPNGRDAL 2770
Score = 56.2 bits (134), Expect = 3e-08
Identities = 62/232 (26%), Positives = 113/232 (48%), Gaps = 31/232 (13%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+QQ EE RLQRE + R++ EAE+A + ++++ RA+E + +K
Sbjct: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922
Query: 78 EEAEKAADESERGMKVIEN----RALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKL 133
++ +A E+ R ++ E RAL +E K + Q + A+ A EA+R +A KL
Sbjct: 1923 KQRLEA--EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA-EAER---VLAEKL 1976
Query: 134 VIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILT 193
I G+ R + AE+A +E++R + A +E + ++ + EE+
Sbjct: 1977 AAI-GEATRLKTEAEIALKEKEAENERLRRL--------AEDEAFQRR--RLEEQ----- 2020
Query: 194 DKLKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
A+ +A+ ER +A+L K D ++ K E+ L +R +++ +L L
Sbjct: 2021 ----AAQHKADIEER-LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILAL 2067
Score = 55.8 bits (133), Expect = 3e-08
Identities = 49/218 (22%), Positives = 95/218 (43%), Gaps = 10/218 (4%)
Query: 11 KRKIQV-LQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQER 69
KR IQ LQQ +E + R+ E R+R + E E+ + +++ E + A+
Sbjct: 1552 KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 70 LATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEV 129
L + EEAE +++ + + + + ++ E++L EA R+ +
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 130 ARKLVIIEGDLERTEERAELAE-SRCREMDEQIRLMDQNLKC-----LSAAEEKYSQKED 183
+ L + E E R AE R R++ + ++ + ++ EK +Q E
Sbjct: 1672 LQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER 1731
Query: 184 KYEEEIKILTDKLKEAETRAE---FAERSVAKLEKTID 218
+EE + +EAE RA+ AER+ + E+ ++
Sbjct: 1732 SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE 1769
Score = 52.8 bits (125), Expect = 3e-07
Identities = 55/202 (27%), Positives = 98/202 (48%), Gaps = 22/202 (10%)
Query: 19 QQADDAEERAERLQREVEGERRAREQAEAEV------ASLNRRIQLVEEELDRAQERLAT 72
Q ++AE RA Q++ E E RARE+AE E+ A+ R++L EE+ + Q+ LA
Sbjct: 1742 QLREEAERRA---QQQAEAE-RAREEAERELERWQLKANEALRLRLQAEEVAQ-QKSLAQ 1796
Query: 73 ALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARK 132
A EAEK +E+ER + + + EL E +L++ + +AE ++ ++
Sbjct: 1797 A-----EAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851
Query: 133 LVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKIL 192
L+ + + E+ E++ +L E + + Q + L A K + E E+ +L
Sbjct: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV-----RAEMEV-LL 1905
Query: 193 TDKLKEAETRAEFAERSVAKLE 214
K + E +E+S +LE
Sbjct: 1906 ASKARAEEESRSTSEKSKQRLE 1927
Score = 52.8 bits (125), Expect = 3e-07
Identities = 57/255 (22%), Positives = 113/255 (44%), Gaps = 27/255 (10%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
+ ++ +++ Q + +E +RL+ E R R Q E E+ S+ R+Q+ EEL +
Sbjct: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV--RVQM--EELSKL 2380
Query: 67 QERLATALQKL-------------EEAEKAADESERGMKVIENRALKDEEKMELQEIQLK 113
+ R+ + L EEAEK +E + + A + +L E L
Sbjct: 2381 KARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLA 2439
Query: 114 EAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSA 173
+ + +AE+ ++ + ++ ++ + E +++ ELA+ + R + E M Q L +
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 174 AEEKYSQKEDKYEEEIKILTDKLK----EAETRAEFAERSVAKLEKTIDDLEDKLKCTKE 229
++ + E + + E+ ++LK E AE + K +++ +KL T+
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE- 2558
Query: 230 EHLCTQR--MLDQTL 242
L TQ L QTL
Sbjct: 2559 --LATQEKVTLVQTL 2571
Score = 52.4 bits (124), Expect = 4e-07
Identities = 56/218 (25%), Positives = 101/218 (46%), Gaps = 13/218 (5%)
Query: 7 IEAVKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRA 66
I A+K + + E R++ E R++EQAE E A R+ QL EE R
Sbjct: 2064 ILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAA---RQRQLAAEEERRR 2120
Query: 67 QERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAK---HIAEEAD 123
+E + L E+AA + + ++ +E K EE L+E +E+ +A+EA
Sbjct: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180
Query: 124 RK---YEEVARKLVI--IEGDLERTEERAELAESRCR-EMDEQIRLMDQNLKCLSAAEEK 177
+K EE A + E +L++T ++ + + R E + R ++ + AE +
Sbjct: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240
Query: 178 YSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEK 215
+Q + EE ++ ++A+ RA+ A+ + KL K
Sbjct: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQ-AQAAAEKLRK 2277
Score = 52.4 bits (124), Expect = 4e-07
Identities = 57/230 (24%), Positives = 103/230 (44%), Gaps = 20/230 (8%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEER ++ E R R+ A EV L +++ +RA++ A LQ
Sbjct: 2117 ERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLA 2176
Query: 78 EEAEKAADESERGMKVIENRALKDEEKMELQEIQ--LKEAKHIAEEADRKYEEVARKLVI 135
+EA + ++E + + E + LQ+ Q L + + AE A R E
Sbjct: 2177 QEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-------- 2228
Query: 136 IEGDLERTEERAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDK 195
E + R + E A+SR R+++E RL +AEE+ + K+ +
Sbjct: 2229 -EAEEARVQAEREAAQSR-RQVEEAERLK-------QSAEEQAQARAQAQAAAEKLRKEA 2279
Query: 196 LKEAETRAEFAERSVAKLEKTIDDLEDKLKCTKEEHLCTQRMLDQTLLDL 245
+EA RA+ AE++ + ++ D +K K E+ L + ++Q L L
Sbjct: 2280 EQEAARRAQ-AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2328
Score = 52.0 bits (123), Expect = 5e-07
Identities = 47/220 (21%), Positives = 104/220 (47%), Gaps = 21/220 (9%)
Query: 6 TIEAVKRKIQVLQQQADDAEERAERLQREVEGERR-------AREQAEAEVASLNRRIQL 58
T+ ++ + ++ +QQ + ER ++ +E +R+ A+ QAE E L +R+Q
Sbjct: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535
Query: 59 VEEELDRAQERLATA----------LQKLEEAEKAADESE-RGMKVIENRALKDEEKMEL 107
EE+ R +E A LQ+L ++ +A +++ R + E L+ EE++ +
Sbjct: 1536 --EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRV 1593
Query: 108 QEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESRCREMDEQIRLMDQN 167
+QL+ + A+ + + + + E + +E AE + ++ ++ R +
Sbjct: 1594 VRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVE 1653
Query: 168 LKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEFAE 207
L AE + ++++ + + ++ L + +EAE R AE
Sbjct: 1654 LASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693
Score = 51.6 bits (122), Expect = 6e-07
Identities = 50/226 (22%), Positives = 109/226 (48%), Gaps = 11/226 (4%)
Query: 2 AGITTIEAVKRKIQVLQQQADDAE-ERAERLQREVE-GERRAREQAEAEVASLNRRIQLV 59
A + +E +K K++ ++ + AE E A +LQ E ++R + + +A ++ ++ Q +
Sbjct: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202
Query: 60 EEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIA 119
++ L + Q L + E A +AA+E+E E A + ++E E +LK++
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE-RLKQSAEEQ 2261
Query: 120 EEADRKYEEVARKL---VIIEGDLERTEERAELAESRC--REMDEQIRLMDQNLKCLSAA 174
+A + + A KL E E+A L + + EM++ + +Q L+ +
Sbjct: 2262 AQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQV 2321
Query: 175 EEKYSQKEDKYEE---EIKILTDKLKEAETRAEFAERSVAKLEKTI 217
E++ + + EE + +L ++L+ + A A R +++E+ +
Sbjct: 2322 EQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEEL 2367
Score = 48.5 bits (114), Expect = 5e-06
Identities = 62/251 (24%), Positives = 109/251 (43%), Gaps = 48/251 (19%)
Query: 10 VKRKIQVLQQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQL-------VEEE 62
++ ++ L++ +D ER + L VE R R Q E E+ +L + +E E
Sbjct: 2028 IEERLAQLRKASDSELERQKGL---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 2084
Query: 63 LDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEA 122
L R + L+ E+AE ++ R L EE+ +E + + K +A E
Sbjct: 2085 LGRIRSNAEDTLRSKEQAE---------LEAARQRQLAAEEERRRREAEERVQKSLAAE- 2134
Query: 123 DRKYEEVARKLVIIEGDLERTEERAE----LAESRCREMDEQIRLMDQNLKCLSAAEEK- 177
EE AR+ ++ER + + E L E +E Q++L + + AEEK
Sbjct: 2135 ----EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190
Query: 178 ----YSQKEDKYEEEI---KILTDKLK-----------EAETRAEFAERSVAKLEKTIDD 219
QKE + ++ + + + D+L+ EAE AER A+ + +++
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 220 LEDKLKCTKEE 230
E +LK + EE
Sbjct: 2251 AE-RLKQSAEE 2260
Score = 38.9 bits (89), Expect = 0.004
Identities = 56/260 (21%), Positives = 111/260 (42%), Gaps = 45/260 (17%)
Query: 2 AGITTIEAVKRKIQVLQQQAD--------------DAEERAERLQREVEGERRAR-EQAE 46
A + +EA K ++ L+ QA+ A+E ERLQ+ GER E+
Sbjct: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR-HGERDVEVERWR 1315
Query: 47 AEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAAD-------------ESERGMKV 93
VA L R Q V + D Q L ++L ++AD E + M +
Sbjct: 1316 ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL 1375
Query: 94 IENRALKDEEKME---LQEIQ-----LKEAKHIAEEADRKYEEVARKLVIIEGDLERTEE 145
+++A++++ + E L+EI+ ++E + A++ ++ +LV + LE
Sbjct: 1376 ADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVAS 1435
Query: 146 RAELAESRCREMDEQIRLMDQNLKCLSAAEEKYSQKEDKYEEEIKILTDKLKEAETRAEF 205
A+ + + + E + +L+ YS+ + IK +++ L+ E
Sbjct: 1436 PAK--KPKVQSGSESVIQEYVDLR------THYSELTTLTSQYIKFISETLRRMEEEERL 1487
Query: 206 AERSVAKLEKTIDDLEDKLK 225
AE+ A+ + + ++E L+
Sbjct: 1488 AEQQRAEERERLAEVEAALE 1507
Score = 31.2 bits (69), Expect = 0.88
Identities = 30/119 (25%), Positives = 57/119 (47%), Gaps = 8/119 (6%)
Query: 18 QQQADDAEERAERLQREVEGERRAREQAEAEVASLNRRIQLVEEELDRAQERLATALQKL 77
+++ +AEE R Q E++ + R Q E +A N+R++ E+L +E+ AL
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR---EQLQLLEEQHRAALAHS 2749
Query: 78 EE---AEKAADES-ERGMKVIENRALKDEEKMELQEIQLK-EAKHIAEEADRKYEEVAR 131
EE ++ AA ++ G ++ A + E + ++ K A+ + E EE+ R
Sbjct: 2750 EEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808
Score = 29.6 bits (65), Expect = 2.5
Identities = 27/121 (22%), Positives = 58/121 (47%), Gaps = 16/121 (13%)
Query: 7 IEAVKRKIQVLQQ----QADDAEERAERLQREVEGERR----AREQAEAEVASLNRRIQL 58
IE K K++ L Q +A E +R Q+++E ER+ + E+A ++
Sbjct: 2646 IEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRR 2705
Query: 59 VEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHI 118
+EEL + ++ Q+ ++ E A+E++R + ++ L+++ + L + A +
Sbjct: 2706 KQEELQQLEQ------QRRQQEELLAEENQRLREQLQ--LLEEQHRAALAHSEEVTASQV 2757
Query: 119 A 119
A
Sbjct: 2758 A 2758
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.313
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 7,552,226
Number of Sequences: 37866
Number of extensions: 334541
Number of successful extensions: 12801
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 689
Number of HSP's successfully gapped in prelim test: 923
Number of HSP's that attempted gapping in prelim test: 3257
Number of HSP's gapped (non-prelim): 5647
length of query: 248
length of database: 18,247,518
effective HSP length: 100
effective length of query: 148
effective length of database: 14,460,918
effective search space: 2140215864
effective search space used: 2140215864
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.