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Search of human proteins with 239755250
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239755250 PREDICTED: chromosome 10 open reading frame 112
[Homo sapiens]
(1542 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Ho... 3263 0.0
gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Ho... 3223 0.0
gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Ho... 3212 0.0
gi|119220585 apical early endosomal glycoprotein precursor [Homo... 195 2e-49
gi|24111244 MAM domain containing glycosylphosphatidylinositol a... 124 5e-28
gi|223278413 MAM domain containing 2 [Homo sapiens] 120 1e-26
gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens] 116 1e-25
gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens] 116 1e-25
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 100 2e-20
gi|223942069 enterokinase precursor [Homo sapiens] 99 3e-20
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 99 4e-20
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 99 4e-20
gi|93102379 low density lipoprotein-related protein 1B precursor... 98 7e-20
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 97 9e-20
gi|119709832 low density lipoprotein receptor-related protein 5 ... 92 3e-18
gi|4507157 sortilin-related receptor containing LDLR class A rep... 92 3e-18
gi|66082554 low density lipoprotein receptor-related protein 8 i... 92 5e-18
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 91 7e-18
gi|61744471 low density lipoprotein receptor-related protein 8 i... 90 1e-17
gi|61744467 low density lipoprotein receptor-related protein 8 i... 90 1e-17
gi|65301119 low density lipoprotein receptor-related protein 8 i... 90 1e-17
gi|157384998 low density lipoprotein receptor-related protein 4 ... 89 4e-17
gi|148727288 low density lipoprotein receptor-related protein 6 ... 87 1e-16
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 85 6e-16
gi|29244926 corin [Homo sapiens] 83 2e-15
gi|134031945 SCO-spondin [Homo sapiens] 82 3e-15
gi|16554449 zonadhesin isoform 3 [Homo sapiens] 81 7e-15
gi|27881494 zonadhesin isoform 6 [Homo sapiens] 81 7e-15
gi|7706111 8D6 antigen [Homo sapiens] 79 3e-14
gi|182508169 neuropilin 1 isoform a [Homo sapiens] 75 5e-13
>gi|239755250 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1542
Score = 3263 bits (8459), Expect = 0.0
Identities = 1542/1542 (100%), Positives = 1542/1542 (100%)
Query: 1 MHITLCEILSSMKIWVSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDH 60
MHITLCEILSSMKIWVSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDH
Sbjct: 1 MHITLCEILSSMKIWVSKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDH 60
Query: 61 SLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHME 120
SLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHME
Sbjct: 61 SLNASQGHFMFILKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHME 120
Query: 121 NSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCT 180
NSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCT
Sbjct: 121 NSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCT 180
Query: 181 LPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWE 240
LPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWE
Sbjct: 181 LPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWE 240
Query: 241 QDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNA 300
QDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNA
Sbjct: 241 QDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNA 300
Query: 301 TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQP 360
TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQP
Sbjct: 301 TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQP 360
Query: 361 FQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEF 420
FQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEF
Sbjct: 361 FQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEF 420
Query: 421 ICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTF 480
ICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTF
Sbjct: 421 ICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTF 480
Query: 481 RWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKC 540
RWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKC
Sbjct: 481 RWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKC 540
Query: 541 TLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAK 600
TLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAK
Sbjct: 541 TLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAK 600
Query: 601 RGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
RGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE
Sbjct: 601 RGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
Query: 661 TTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIF 720
TTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIF
Sbjct: 661 TTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIF 720
Query: 721 INSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNL 780
INSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNL
Sbjct: 721 INSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNL 780
Query: 781 TVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELA 840
TVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELA
Sbjct: 781 TVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELA 840
Query: 841 VPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQA 900
VPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQA
Sbjct: 841 VPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQA 900
Query: 901 DNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCS 960
DNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCS
Sbjct: 901 DNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCS 960
Query: 961 VSKLEARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACT 1020
VSKLEARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACT
Sbjct: 961 VSKLEARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACT 1020
Query: 1021 MSFWYFISAKATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRAR 1080
MSFWYFISAKATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRAR
Sbjct: 1021 MSFWYFISAKATGSIQILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRAR 1080
Query: 1081 AFPEPECPRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCD 1140
AFPEPECPRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCD
Sbjct: 1081 AFPEPECPRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCD 1140
Query: 1141 YKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKAL 1200
YKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKAL
Sbjct: 1141 YKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKAL 1200
Query: 1201 IPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGIL 1260
IPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGIL
Sbjct: 1201 IPDSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGIL 1260
Query: 1261 KVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDIS 1320
KVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDIS
Sbjct: 1261 KVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDIS 1320
Query: 1321 FTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP 1380
FTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP
Sbjct: 1321 FTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP 1380
Query: 1381 LCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQR 1440
LCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQR
Sbjct: 1381 LCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQR 1440
Query: 1441 CDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCA 1500
CDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCA
Sbjct: 1441 CDGFADCMDFQLDESSCSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCA 1500
Query: 1501 FVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK 1542
FVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK
Sbjct: 1501 FVNPVYGNWSNPEKTESSVYSFSNPLYGTTSGSLETLSHHLK 1542
>gi|239749752 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 3223 bits (8357), Expect = 0.0
Identities = 1523/1526 (99%), Positives = 1524/1526 (99%)
Query: 17 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS 76
SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS
Sbjct: 292 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS 351
Query: 77 SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG
Sbjct: 352 SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 411
Query: 137 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 196
KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC
Sbjct: 412 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 471
Query: 197 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT 256
RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT
Sbjct: 472 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT 531
Query: 257 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 316
PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG
Sbjct: 532 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 591
Query: 317 KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD 376
KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD
Sbjct: 592 KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD 651
Query: 377 IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD 436
IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD
Sbjct: 652 IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD 711
Query: 437 FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN 496
FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN
Sbjct: 712 FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN 771
Query: 497 HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL 556
HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL
Sbjct: 772 HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL 831
Query: 557 QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF 616
QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF
Sbjct: 832 QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF 891
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF
Sbjct: 892 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 951
Query: 677 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARIS 736
DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFI SLFPQQPMRAARIS
Sbjct: 952 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARIS 1011
Query: 737 SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF 796
SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF
Sbjct: 1012 SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF 1071
Query: 797 GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH 856
GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH
Sbjct: 1072 GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH 1131
Query: 857 NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR 916
NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR
Sbjct: 1132 NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR 1191
Query: 917 PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN 976
PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN
Sbjct: 1192 PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN 1251
Query: 977 ENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQ 1036
ENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQ
Sbjct: 1252 ENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQ 1311
Query: 1037 ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK 1096
ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK
Sbjct: 1312 ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK 1371
Query: 1097 GPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAH 1156
GPPQE+PNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCS RSDEAHCAH
Sbjct: 1372 GPPQEKPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAH 1431
Query: 1157 YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY 1216
YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY
Sbjct: 1432 YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY 1491
Query: 1217 VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS 1276
VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS
Sbjct: 1492 VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS 1551
Query: 1277 VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS 1336
VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS
Sbjct: 1552 VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS 1611
Query: 1337 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP
Sbjct: 1612 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1671
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS
Sbjct: 1672 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1731
Query: 1457 CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE 1516
CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE
Sbjct: 1732 CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE 1791
Query: 1517 SSVYSFSNPLYGTTSGSLETLSHHLK 1542
SSVYSFSNPLYGTTSGSLETLSHHLK
Sbjct: 1792 SSVYSFSNPLYGTTSGSLETLSHHLK 1817
Score = 338 bits (867), Expect = 2e-92
Identities = 285/1010 (28%), Positives = 437/1010 (43%), Gaps = 168/1010 (16%)
Query: 19 CDFEANSCDWFEAISGD-HFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSS 77
CDFE+ C W ++ D H+ ++ + EH P DH+ N + G F+++ + S
Sbjct: 116 CDFESGFCGWEPFLTEDSHWKLMKGLNNG-----EHHFPAADHTANINHGSFIYLEAQRS 170
Query: 78 SLWQVAKLQSPTFSQ---TGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYN 134
VAKL SP ++ C + FW Y LS + L + S D L
Sbjct: 171 P--GVAKLGSPVLTKLLTASTPCQVQFW---YHLS-QHSNLSVFTRTSLDGN-----LQK 219
Query: 135 QGK-------QWLEATIQL----GRLSQPFHLSLDKVSLGIYDGVSAIDDIRF-ENCTL- 181
QGK QW A I L G + PF L L+ L + A+DDI + C +
Sbjct: 220 QGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLS-SNATVALDDISVSQECEIS 278
Query: 182 --PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNW 239
LP S T++ K C+FE C+W
Sbjct: 279 YKSLPRTS-----------TQSKFSK------------------------CDFEANSCDW 303
Query: 240 -EQDAKDDFDWTRNQGPTPTL---NTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLS 295
E + D FDW R+ + + P +D++L ++GH+++I +Q A L S
Sbjct: 304 FEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQ-VAKLQS 362
Query: 296 PILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNI 355
P + T GC F+++ +G + + + + ++W++ NQG +W+ + +
Sbjct: 363 PTFSQTG-PGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQL 421
Query: 356 SS-RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHN 414
QPF + ++ + G AIDD+ F +CTL LP +
Sbjct: 422 GRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTL-------------------PLPAES 462
Query: 415 CTD-NEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV-CSFEKRSLCKWYQPIPVH 472
C + F CR CIEK++ CD DC D++DE +C E+ C+FE +C W Q
Sbjct: 463 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFE-TGICNWEQ----- 516
Query: 473 LLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGK-FGDTADILTP 531
+ F W G + N P D+T T G YLY +SS + F D+A +L+P
Sbjct: 517 --DAKDDFDWTRNQGPT---PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSP 571
Query: 532 IISLTGPK-CTLVFWTHMNGATVGSLQVL--IKKDNVTSKLWAQTGQQGAQWKRAEVFLG 588
I++ T K CT F+ HM G + L + I D+ LW G QG +W R + +
Sbjct: 572 ILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNIS 631
Query: 589 IRSHTQIVFRAKRGISYIGDVAVDDISFQDCS------------------PLLSPERKCT 630
R QI+ A G + GD+A+DD+SF DC+ P+ P CT
Sbjct: 632 SRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCT 691
Query: 631 DHEFMC-ANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE-FDLCSWKQ----- 683
D+EF+C ++ HCI K + CDF DC D SDE + + C FE LC W Q
Sbjct: 692 DNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV----CSFEKRSLCKWYQPIPVH 747
Query: 684 --EKDEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFINSLFPQQPMRAARISSP 738
+ F W L G E P+ DHT + G Y++ +S + A I +P
Sbjct: 748 LLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFG-DTADILTP 806
Query: 739 VISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGD 798
+IS C ++F HM G +G+L ++ + N T L T +QG W+R E+ L
Sbjct: 807 IISLTGPKCTLVFWTHMNGATVGSLQVL-IKKDNVTSKLWAQTGQQGAQWKRAEVFLGIR 865
Query: 799 EDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNG 858
Q+ F + G GD+A+DDI S Q+ + P C C N
Sbjct: 866 SHTQIVFRAKRGISYIGDVAVDDI-----------SFQDCSPLLSPERKCTDHEFMCANK 914
Query: 859 KCYRLEQSCNFVDNCGDNTGENK--CGSS---CTFEKGWCGWQNSQADNFDWVLGVGS-- 911
C ++ C+FV++C DN+ E C +S C FE C W+ + ++FDW L S
Sbjct: 915 HCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIP 974
Query: 912 HQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSV 961
P DHTLGN + + + +P + + + + ++ NC +
Sbjct: 975 AAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKI 1024
Score = 297 bits (760), Expect = 6e-80
Identities = 229/839 (27%), Positives = 367/839 (43%), Gaps = 106/839 (12%)
Query: 122 SHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTL 181
S + + W + QW++A + + + F + + L + A+D + C
Sbjct: 9 SKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFI-ALDHLWVYACGQ 67
Query: 182 PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDE--VNCAPELQCNFETGICNW 239
+ C D F C + CI K +CD DC D +DE C+ L C+FE+G C W
Sbjct: 68 TQSRKLCSA-DEFPCTSGQ-CIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCGW 125
Query: 240 EQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILN 299
E +D W +G + P D+T G ++Y+E+ Q A L SP+L
Sbjct: 126 EPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGVAKLGSPVLT 182
Query: 300 --ATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNI-- 355
T + C +F+YH+ + L+++ R D Q +I ++W +++
Sbjct: 183 KLLTASTPCQVQFWYHL--SQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIA 240
Query: 356 ---SSRQPFQILVEASVGDGFTGDIAIDDLSF-MDCTLYPGNLPADLPTPPETSVPVTLP 411
S PFQ+++EA+V +A+DD+S +C + +L P TS
Sbjct: 241 EAGESTLPFQLILEATVLSS-NATVALDDISVSQECEISYKSL-------PRTSTQ---- 288
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV 471
K KCDF + + C W++ I
Sbjct: 289 ------------------SKFSKCDF---------------------EANSCDWFEAI-- 307
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTP 531
+ F W + + E+ P DH+ N + G +++ + A + +P
Sbjct: 308 ----SGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQVAKLQSP 363
Query: 532 IISLTGPKCTLVFWTHMNGATVGS--LQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGI 589
S TGP C L FW + G +VG+ LQ+ ++ + ++ +W QG QW A + LG
Sbjct: 364 TFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGR 423
Query: 590 RSHTQIVFRAKRGIS-YIGDVAVDDISFQDCS-PLLSPERKCTDHEFMCANKHCIAKDKL 647
S + K + Y G A+DDI F++C+ PL + + DH + + CI K +L
Sbjct: 424 LSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRL 483
Query: 648 CDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAA 707
CD V+DC D +DE C +C+FE +C+W+Q+ +DFDW P T P
Sbjct: 484 CDLVDDCGDRTDEVN--CAPEL-QCNFETGICNWEQDAKDDFDWTRNQGPTPTLNTGPMK 540
Query: 708 DHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKR-SKNCKIIFHYHMYGNGIGALTLM 766
D+TLG + GHY++I S PQ +A + SP+++ +K C F+YHM+G I L +
Sbjct: 541 DNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIY 600
Query: 767 Q-VSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLT 825
Q + ++ ++L + QGN W R+ L++ + FQ+ E VG G GDIA+DD+
Sbjct: 601 QRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFM 660
Query: 826 ENCL-------SLHDSVQEELAVPLPTGFCPLGYRECH-NGKCYRLEQSCNFVDNCGDNT 877
+ L L + + V LP C C +G C Q C+F +C D +
Sbjct: 661 DCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKS 720
Query: 878 GENKCGSS-CTFEK-GWCGWQN-------SQADNFDWVLGVG-----SHQSLRPPKDHT 922
E C C+FEK C W ++ F W LG G ++ RP DHT
Sbjct: 721 DEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHT 779
Score = 167 bits (422), Expect = 9e-41
Identities = 155/538 (28%), Positives = 232/538 (43%), Gaps = 94/538 (17%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE--ASCVMEV-CSFEKRSLCKWYQPIPV 471
C+ +EF C S G CI K CD + DC D+SDE A+C + C FE C W +P
Sbjct: 74 CSADEFPCTS-GQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFES-GFCGW-EPF-- 128
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY--ADSSNGKFGDTADIL 529
L +DS+ W L G+ + E+H P+ DHT N G ++Y A S G + +L
Sbjct: 129 -LTEDSH---WKLMKGL---NNGEHHFPAADHTANINHGSFIYLEAQRSPGVAKLGSPVL 181
Query: 530 TPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGI 589
T +++ + P C + FW H++ + S+ D K +QW A++ L
Sbjct: 182 TKLLTASTP-CQVQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIA 240
Query: 590 RSHT-----QIVFRAKRGISYIGDVAVDDISF-QDCS-PLLSPERKCTDHEFMCANKHCI 642
+ Q++ A +S VA+DDIS Q+C S R T +F
Sbjct: 241 EAGESTLPFQLILEA-TVLSSNATVALDDISVSQECEISYKSLPRTSTQSKF-------- 291
Query: 643 AKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDED-FDWNLKASSIPAA 701
+CDFE + C W + D FDW + S +A
Sbjct: 292 ---------------------------SKCDFEANSCDWFEAISGDHFDWIRSSQSELSA 324
Query: 702 GTE---PAADHTLGNSSGHYIFI----NSLFPQQPMRAARISSPVISKRSKNCKIIFHYH 754
E P DH+L S GH++FI +SL+ + A++ SP S+ C + F ++
Sbjct: 325 DFEHQAPPRDHSLNASQGHFMFILKKSSSLW-----QVAKLQSPTFSQTGPGCILSFWFY 379
Query: 755 MYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFG-DEDFQLKFEGRVGKG 812
YG +GA L + + ++ + V+ + QG W + L + F L + +V G
Sbjct: 380 NYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLD-KVSLG 438
Query: 813 QRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCP-LGYREC-HNGKCYRLEQSCNFV 870
++ D + ENC +PLP C L + C H C + C+ V
Sbjct: 439 IYDGVSAIDDIRFENC-----------TLPLPAESCEGLDHFWCRHTRACIEKLRLCDLV 487
Query: 871 DNCGDNTGENKCGS--SCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR--PPKDHTLG 924
D+CGD T E C C FE G C W+ D+FDW G +L P KD+TLG
Sbjct: 488 DDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLG 545
Score = 108 bits (269), Expect = 5e-23
Identities = 103/388 (26%), Positives = 152/388 (39%), Gaps = 76/388 (19%)
Query: 558 VLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHT-QIVFRAKRGISYIGDVAVDDISF 616
V + K W +QW +A+V + T +I+F +S +A+D +
Sbjct: 4 VFLFKSKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTL-LSQRSFIALDHLWV 62
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
C S + C+ EF C + CIAK+ +CD DC+D SDE C + CDFE
Sbjct: 63 YACGQTQS-RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATC-SKHLTCDFES 120
Query: 677 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARIS 736
C W+ ED W L PAADHT + G +I++ + Q+ A++
Sbjct: 121 GFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGVAKLG 177
Query: 737 SPVISK---RSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNF------ 787
SPV++K S C++ F YH+ + +SV +T + NL +QG
Sbjct: 178 SPVLTKLLTASTPCQVQFWYHLSQHS-------NLSVFTRTSLDGNLQ-KQGKIIRFSES 229
Query: 788 -WRREELSLFGDE-----DFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAV 841
W ++ L + FQL E V +ALDDI SV +E
Sbjct: 230 QWSHAKIDLIAEAGESTLPFQLILEATV-LSSNATVALDDI-----------SVSQE--- 274
Query: 842 PLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGW-QNSQA 900
C + Y+ T S C FE C W +
Sbjct: 275 ------CEISYKSL-------------------PRTSTQSKFSKCDFEANSCDWFEAISG 309
Query: 901 DNFDWVLGVGSHQSL-----RPPKDHTL 923
D+FDW+ S S PP+DH+L
Sbjct: 310 DHFDWIRSSQSELSADFEHQAPPRDHSL 337
Score = 62.4 bits (150), Expect = 3e-09
Identities = 55/212 (25%), Positives = 98/212 (46%), Gaps = 24/212 (11%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDE--AHCAHYTSTTGSCNFETSSGNWTTACSLTQ 1181
+F C +CIA +CD + DCS SDE A C+ + +C+FE+ W LT+
Sbjct: 78 EFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHL----TCDFESGFCGWEP--FLTE 131
Query: 1182 DSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARI---TTSKSFPA 1238
DS L + + + P +DHT + H ++ + VA++ +K A
Sbjct: 132 DSHWKLMKGLNN---GEHHFPAADHT-ANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTA 187
Query: 1239 SLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPL-----S 1293
S C V+FW+++ ++ + +++ G +I + W++ + L
Sbjct: 188 ST-PCQVQFWYHLSQHSNLSVFTRTSLD--GNLQKQGKIIRFSESQWSHAKIDLIAEAGE 244
Query: 1294 SNSPFKVAFEADLDGNEDIFIALDDISFTPEC 1325
S PF++ EA + + + +ALDDIS + EC
Sbjct: 245 STLPFQLILEATV-LSSNATVALDDISVSQEC 275
Score = 38.5 bits (88), Expect = 0.051
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 8/99 (8%)
Query: 1273 LVWSVIGNKRTGWTYGSVPLSSN-SPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPV 1331
+ W+ + + W V + + FK+ FE L FIALD + V
Sbjct: 14 IFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRS-FIALDHL-----WVYACGQ 67
Query: 1332 PVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE 1370
C AD+F C + QC+ CD +DC D SDE
Sbjct: 68 TQSRKLCSADEFPCT-SGQCIAKESVCDSRQDCSDESDE 105
Score = 37.4 bits (85), Expect = 0.11
Identities = 16/41 (39%), Positives = 21/41 (51%)
Query: 1373 CPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDE 1413
C + LCS EFPC++ +CI +CD DC DE
Sbjct: 65 CGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
>gi|239744011 PREDICTED: chromosome 10 open reading frame 112 [Homo
sapiens]
Length = 1817
Score = 3212 bits (8329), Expect = 0.0
Identities = 1517/1526 (99%), Positives = 1522/1526 (99%)
Query: 17 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS 76
SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS
Sbjct: 292 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKS 351
Query: 77 SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG
Sbjct: 352 SSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 411
Query: 137 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 196
KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC
Sbjct: 412 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 471
Query: 197 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT 256
RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTR+QGPT
Sbjct: 472 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPT 531
Query: 257 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 316
PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG
Sbjct: 532 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 591
Query: 317 KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD 376
KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD
Sbjct: 592 KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGD 651
Query: 377 IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD 436
IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD
Sbjct: 652 IAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCD 711
Query: 437 FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN 496
FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN
Sbjct: 712 FKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEEN 771
Query: 497 HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL 556
HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL
Sbjct: 772 HRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSL 831
Query: 557 QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF 616
QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF
Sbjct: 832 QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF 891
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF
Sbjct: 892 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 951
Query: 677 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARIS 736
DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFI SLFPQQPMRAARIS
Sbjct: 952 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARIS 1011
Query: 737 SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF 796
SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF
Sbjct: 1012 SPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLF 1071
Query: 797 GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH 856
GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH
Sbjct: 1072 GDEDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECH 1131
Query: 857 NGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR 916
NGKCYRLEQSCNFVDNCGDNT EN+CGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR
Sbjct: 1132 NGKCYRLEQSCNFVDNCGDNTDENECGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR 1191
Query: 917 PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN 976
PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN
Sbjct: 1192 PPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPN 1251
Query: 977 ENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQ 1036
ENTFGSSDH NWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYF+SAKATGSIQ
Sbjct: 1252 ENTFGSSDHTNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFVSAKATGSIQ 1311
Query: 1037 ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK 1096
ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK
Sbjct: 1312 ILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLK 1371
Query: 1097 GPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAH 1156
GPPQE+PNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCS RSDEAHCAH
Sbjct: 1372 GPPQEKPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSDRSDEAHCAH 1431
Query: 1157 YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY 1216
YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY
Sbjct: 1432 YTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLY 1491
Query: 1217 VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS 1276
VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS
Sbjct: 1492 VNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWS 1551
Query: 1277 VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS 1336
VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS
Sbjct: 1552 VIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS 1611
Query: 1337 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPL+PTPPLCSNMEFPCSTDECIP
Sbjct: 1612 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLSPTPPLCSNMEFPCSTDECIP 1671
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS
Sbjct: 1672 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1731
Query: 1457 CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE 1516
CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE
Sbjct: 1732 CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIRKTEGSGNCAFVNPVYGNWSNPEKTE 1791
Query: 1517 SSVYSFSNPLYGTTSGSLETLSHHLK 1542
SSVYSFSNPLYGTTSGSLETLSHHLK
Sbjct: 1792 SSVYSFSNPLYGTTSGSLETLSHHLK 1817
Score = 338 bits (867), Expect = 2e-92
Identities = 285/1010 (28%), Positives = 437/1010 (43%), Gaps = 168/1010 (16%)
Query: 19 CDFEANSCDWFEAISGD-HFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSS 77
CDFE+ C W ++ D H+ ++ + EH P DH+ N + G F+++ + S
Sbjct: 116 CDFESGFCGWEPFLTEDSHWKLMKGLNNG-----EHHFPAADHTANINHGSFIYLEAQRS 170
Query: 78 SLWQVAKLQSPTFSQ---TGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYN 134
VAKL SP ++ C + FW Y LS + L + S D L
Sbjct: 171 P--GVAKLGSPVLTKLLTASTPCQVQFW---YHLS-QHSNLSVFTRTSLDGN-----LQK 219
Query: 135 QGK-------QWLEATIQL----GRLSQPFHLSLDKVSLGIYDGVSAIDDIRF-ENCTL- 181
QGK QW A I L G + PF L L+ L + A+DDI + C +
Sbjct: 220 QGKIIRFSESQWSHAKIDLIAEAGESTLPFQLILEATVLS-SNATVALDDISVSQECEIS 278
Query: 182 --PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNW 239
LP S T++ K C+FE C+W
Sbjct: 279 YKSLPRTS-----------TQSKFSK------------------------CDFEANSCDW 303
Query: 240 -EQDAKDDFDWTRNQGPTPTL---NTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLS 295
E + D FDW R+ + + P +D++L ++GH+++I +Q A L S
Sbjct: 304 FEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQ-VAKLQS 362
Query: 296 PILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNI 355
P + T GC F+++ +G + + + + ++W++ NQG +W+ + +
Sbjct: 363 PTFSQTG-PGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQL 421
Query: 356 SS-RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHN 414
QPF + ++ + G AIDD+ F +CTL LP +
Sbjct: 422 GRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTL-------------------PLPAES 462
Query: 415 CTD-NEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV-CSFEKRSLCKWYQPIPVH 472
C + F CR CIEK++ CD DC D++DE +C E+ C+FE +C W Q
Sbjct: 463 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFE-TGICNWEQ----- 516
Query: 473 LLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGK-FGDTADILTP 531
+ F W G + N P D+T T G YLY +SS + F D+A +L+P
Sbjct: 517 --DAKDDFDWTRSQGPT---PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSP 571
Query: 532 IISLTGPK-CTLVFWTHMNGATVGSLQVL--IKKDNVTSKLWAQTGQQGAQWKRAEVFLG 588
I++ T K CT F+ HM G + L + I D+ LW G QG +W R + +
Sbjct: 572 ILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNIS 631
Query: 589 IRSHTQIVFRAKRGISYIGDVAVDDISFQDCS------------------PLLSPERKCT 630
R QI+ A G + GD+A+DD+SF DC+ P+ P CT
Sbjct: 632 SRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCT 691
Query: 631 DHEFMC-ANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE-FDLCSWKQ----- 683
D+EF+C ++ HCI K + CDF DC D SDE + + C FE LC W Q
Sbjct: 692 DNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV----CSFEKRSLCKWYQPIPVH 747
Query: 684 --EKDEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFINSLFPQQPMRAARISSP 738
+ F W L G E P+ DHT + G Y++ +S + A I +P
Sbjct: 748 LLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFG-DTADILTP 806
Query: 739 VISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGD 798
+IS C ++F HM G +G+L ++ + N T L T +QG W+R E+ L
Sbjct: 807 IISLTGPKCTLVFWTHMNGATVGSLQVL-IKKDNVTSKLWAQTGQQGAQWKRAEVFLGIR 865
Query: 799 EDFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNG 858
Q+ F + G GD+A+DDI S Q+ + P C C N
Sbjct: 866 SHTQIVFRAKRGISYIGDVAVDDI-----------SFQDCSPLLSPERKCTDHEFMCANK 914
Query: 859 KCYRLEQSCNFVDNCGDNTGENK--CGSS---CTFEKGWCGWQNSQADNFDWVLGVGS-- 911
C ++ C+FV++C DN+ E C +S C FE C W+ + ++FDW L S
Sbjct: 915 HCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIP 974
Query: 912 HQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSV 961
P DHTLGN + + + +P + + + + ++ NC +
Sbjct: 975 AAGTEPAADHTLGNSSGHYIFIKSLFPQQPMRAARISSPVISKRSKNCKI 1024
Score = 297 bits (760), Expect = 6e-80
Identities = 229/839 (27%), Positives = 367/839 (43%), Gaps = 106/839 (12%)
Query: 122 SHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTL 181
S + + W + QW++A + + + F + + L + A+D + C
Sbjct: 9 SKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRSFI-ALDHLWVYACGQ 67
Query: 182 PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDE--VNCAPELQCNFETGICNW 239
+ C D F C + CI K +CD DC D +DE C+ L C+FE+G C W
Sbjct: 68 TQSRKLCSA-DEFPCTSGQ-CIAKESVCDSRQDCSDESDEDPATCSKHLTCDFESGFCGW 125
Query: 240 EQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILN 299
E +D W +G + P D+T G ++Y+E+ Q A L SP+L
Sbjct: 126 EPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGVAKLGSPVLT 182
Query: 300 --ATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNI-- 355
T + C +F+YH+ + L+++ R D Q +I ++W +++
Sbjct: 183 KLLTASTPCQVQFWYHL--SQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIA 240
Query: 356 ---SSRQPFQILVEASVGDGFTGDIAIDDLSF-MDCTLYPGNLPADLPTPPETSVPVTLP 411
S PFQ+++EA+V +A+DD+S +C + +L P TS
Sbjct: 241 EAGESTLPFQLILEATVLSS-NATVALDDISVSQECEISYKSL-------PRTSTQ---- 288
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV 471
K KCDF + + C W++ I
Sbjct: 289 ------------------SKFSKCDF---------------------EANSCDWFEAI-- 307
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTP 531
+ F W + + E+ P DH+ N + G +++ + A + +P
Sbjct: 308 ----SGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSLWQVAKLQSP 363
Query: 532 IISLTGPKCTLVFWTHMNGATVGS--LQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGI 589
S TGP C L FW + G +VG+ LQ+ ++ + ++ +W QG QW A + LG
Sbjct: 364 TFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGR 423
Query: 590 RSHTQIVFRAKRGIS-YIGDVAVDDISFQDCS-PLLSPERKCTDHEFMCANKHCIAKDKL 647
S + K + Y G A+DDI F++C+ PL + + DH + + CI K +L
Sbjct: 424 LSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRL 483
Query: 648 CDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAA 707
CD V+DC D +DE C +C+FE +C+W+Q+ +DFDW P T P
Sbjct: 484 CDLVDDCGDRTDEVN--CAPEL-QCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTGPMK 540
Query: 708 DHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKR-SKNCKIIFHYHMYGNGIGALTLM 766
D+TLG + GHY++I S PQ +A + SP+++ +K C F+YHM+G I L +
Sbjct: 541 DNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIY 600
Query: 767 Q-VSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLT 825
Q + ++ ++L + QGN W R+ L++ + FQ+ E VG G GDIA+DD+
Sbjct: 601 QRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFM 660
Query: 826 ENCL-------SLHDSVQEELAVPLPTGFCPLGYRECH-NGKCYRLEQSCNFVDNCGDNT 877
+ L L + + V LP C C +G C Q C+F +C D +
Sbjct: 661 DCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKS 720
Query: 878 GENKCGSS-CTFEK-GWCGWQN-------SQADNFDWVLGVG-----SHQSLRPPKDHT 922
E C C+FEK C W ++ F W LG G ++ RP DHT
Sbjct: 721 DEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHT 779
Score = 167 bits (422), Expect = 9e-41
Identities = 155/538 (28%), Positives = 232/538 (43%), Gaps = 94/538 (17%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE--ASCVMEV-CSFEKRSLCKWYQPIPV 471
C+ +EF C S G CI K CD + DC D+SDE A+C + C FE C W +P
Sbjct: 74 CSADEFPCTS-GQCIAKESVCDSRQDCSDESDEDPATCSKHLTCDFES-GFCGW-EPF-- 128
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY--ADSSNGKFGDTADIL 529
L +DS+ W L G+ + E+H P+ DHT N G ++Y A S G + +L
Sbjct: 129 -LTEDSH---WKLMKGL---NNGEHHFPAADHTANINHGSFIYLEAQRSPGVAKLGSPVL 181
Query: 530 TPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGI 589
T +++ + P C + FW H++ + S+ D K +QW A++ L
Sbjct: 182 TKLLTASTP-CQVQFWYHLSQHSNLSVFTRTSLDGNLQKQGKIIRFSESQWSHAKIDLIA 240
Query: 590 RSHT-----QIVFRAKRGISYIGDVAVDDISF-QDCS-PLLSPERKCTDHEFMCANKHCI 642
+ Q++ A +S VA+DDIS Q+C S R T +F
Sbjct: 241 EAGESTLPFQLILEA-TVLSSNATVALDDISVSQECEISYKSLPRTSTQSKF-------- 291
Query: 643 AKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDED-FDWNLKASSIPAA 701
+CDFE + C W + D FDW + S +A
Sbjct: 292 ---------------------------SKCDFEANSCDWFEAISGDHFDWIRSSQSELSA 324
Query: 702 GTE---PAADHTLGNSSGHYIFI----NSLFPQQPMRAARISSPVISKRSKNCKIIFHYH 754
E P DH+L S GH++FI +SL+ + A++ SP S+ C + F ++
Sbjct: 325 DFEHQAPPRDHSLNASQGHFMFILKKSSSLW-----QVAKLQSPTFSQTGPGCILSFWFY 379
Query: 755 MYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFG-DEDFQLKFEGRVGKG 812
YG +GA L + + ++ + V+ + QG W + L + F L + +V G
Sbjct: 380 NYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLD-KVSLG 438
Query: 813 QRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCP-LGYREC-HNGKCYRLEQSCNFV 870
++ D + ENC +PLP C L + C H C + C+ V
Sbjct: 439 IYDGVSAIDDIRFENC-----------TLPLPAESCEGLDHFWCRHTRACIEKLRLCDLV 487
Query: 871 DNCGDNTGENKCGS--SCTFEKGWCGWQNSQADNFDWVLGVGSHQSLR--PPKDHTLG 924
D+CGD T E C C FE G C W+ D+FDW G +L P KD+TLG
Sbjct: 488 DDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRSQGPTPTLNTGPMKDNTLG 545
Score = 108 bits (269), Expect = 5e-23
Identities = 103/388 (26%), Positives = 152/388 (39%), Gaps = 76/388 (19%)
Query: 558 VLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHT-QIVFRAKRGISYIGDVAVDDISF 616
V + K W +QW +A+V + T +I+F +S +A+D +
Sbjct: 4 VFLFKSKEEEIFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTL-LSQRSFIALDHLWV 62
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
C S + C+ EF C + CIAK+ +CD DC+D SDE C + CDFE
Sbjct: 63 YACGQTQS-RKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDEDPATC-SKHLTCDFES 120
Query: 677 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARIS 736
C W+ ED W L PAADHT + G +I++ + Q+ A++
Sbjct: 121 GFCGWEPFLTEDSHWKLMKGLNNGEHHFPAADHTANINHGSFIYLEA---QRSPGVAKLG 177
Query: 737 SPVISK---RSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNF------ 787
SPV++K S C++ F YH+ + +SV +T + NL +QG
Sbjct: 178 SPVLTKLLTASTPCQVQFWYHLSQHS-------NLSVFTRTSLDGNLQ-KQGKIIRFSES 229
Query: 788 -WRREELSLFGDE-----DFQLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAV 841
W ++ L + FQL E V +ALDDI SV +E
Sbjct: 230 QWSHAKIDLIAEAGESTLPFQLILEATV-LSSNATVALDDI-----------SVSQE--- 274
Query: 842 PLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGW-QNSQA 900
C + Y+ T S C FE C W +
Sbjct: 275 ------CEISYKSL-------------------PRTSTQSKFSKCDFEANSCDWFEAISG 309
Query: 901 DNFDWVLGVGSHQSL-----RPPKDHTL 923
D+FDW+ S S PP+DH+L
Sbjct: 310 DHFDWIRSSQSELSADFEHQAPPRDHSL 337
Score = 62.4 bits (150), Expect = 3e-09
Identities = 55/212 (25%), Positives = 98/212 (46%), Gaps = 24/212 (11%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDE--AHCAHYTSTTGSCNFETSSGNWTTACSLTQ 1181
+F C +CIA +CD + DCS SDE A C+ + +C+FE+ W LT+
Sbjct: 78 EFPCTSGQCIAKESVCDSRQDCSDESDEDPATCSKHL----TCDFESGFCGWEP--FLTE 131
Query: 1182 DSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARI---TTSKSFPA 1238
DS L + + + P +DHT + H ++ + VA++ +K A
Sbjct: 132 DSHWKLMKGLNN---GEHHFPAADHT-ANINHGSFIYLEAQRSPGVAKLGSPVLTKLLTA 187
Query: 1239 SLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPL-----S 1293
S C V+FW+++ ++ + +++ G +I + W++ + L
Sbjct: 188 ST-PCQVQFWYHLSQHSNLSVFTRTSLD--GNLQKQGKIIRFSESQWSHAKIDLIAEAGE 244
Query: 1294 SNSPFKVAFEADLDGNEDIFIALDDISFTPEC 1325
S PF++ EA + + + +ALDDIS + EC
Sbjct: 245 STLPFQLILEATV-LSSNATVALDDISVSQEC 275
Score = 38.5 bits (88), Expect = 0.051
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 8/99 (8%)
Query: 1273 LVWSVIGNKRTGWTYGSVPLSSN-SPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPV 1331
+ W+ + + W V + + FK+ FE L FIALD + V
Sbjct: 14 IFWTYNISTHSQWVKADVLIPEDLKTFKIIFEGTLLSQRS-FIALDHL-----WVYACGQ 67
Query: 1332 PVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE 1370
C AD+F C + QC+ CD +DC D SDE
Sbjct: 68 TQSRKLCSADEFPCT-SGQCIAKESVCDSRQDCSDESDE 105
Score = 37.4 bits (85), Expect = 0.11
Identities = 16/41 (39%), Positives = 21/41 (51%)
Query: 1373 CPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDE 1413
C + LCS EFPC++ +CI +CD DC DE
Sbjct: 65 CGQTQSRKLCSADEFPCTSGQCIAKESVCDSRQDCSDESDE 105
>gi|119220585 apical early endosomal glycoprotein precursor [Homo
sapiens]
Length = 1137
Score = 195 bits (496), Expect = 2e-49
Identities = 149/543 (27%), Positives = 230/543 (42%), Gaps = 65/543 (11%)
Query: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
CDFE + C W + IS + W+R A E P DH+L G +M +
Sbjct: 66 CDFEQDPCGWRD-ISTSGYSWLRD---RAGAALEGPGPHSDHTLGTDLGWYMAVGTHRGK 121
Query: 79 LWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGKQ 138
A L+SPT + C L W++ S AEL++ + + ++ +W+ G
Sbjct: 122 EASTAALRSPTLREAASSCKLRLWYH--AASGDVAELRVELTHGAETLTLWQSTGPWGPG 179
Query: 139 WLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRH 198
W E + GR+ F ++ + G A+DD+ F +C LP P +C H C++
Sbjct: 180 WQELAVTTGRIRGDFRVTFSATRNATHRGAVALDDLEFWDCGLPTPQANCPP-GHHHCQN 238
Query: 199 TRACIEKLRLCDLVDDCGDRTDE--VNCAPELQCNFETGICNWEQDAKDDFDWTRN-QGP 255
+ C+E +LCD D+CGD +DE + C + +FETG+ W + W+RN +
Sbjct: 239 -KVCVEPQQLCDGEDNCGDLSDENPLTCGRHIATDFETGLGPWNRSE----GWSRNHRAG 293
Query: 256 TPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMF 315
P + P +D++ +A+G +L + +EP A L SP A+ T C+ FY ++
Sbjct: 294 GPERPSWPRRDHSRNSAQGSFL-VSVAEPGT---PAILSSPEFQASGTSNCSLVFYQYLS 349
Query: 316 GKRIYRLAIYQRIWSDSRGQ---LLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDG 372
G L ++ + + LL + G G W+R ++I S PFQIL+ G G
Sbjct: 350 GSEAGCLQLFLQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILLAGQTGPG 409
Query: 373 FTGDIAIDDLSFMD--------CTLYPGNLPADLPTPPETSVPVTLPP-----HNCTDNE 419
G + +DDL D TL P LP P P LPP +C
Sbjct: 410 --GVVGLDDLILSDHCRPVSEVSTLQP------LPPGPRAPAPQPLPPSSRLQDSCKQGH 461
Query: 420 FICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNT 479
C C+ Q CDF+ C DE +C FE W + V LQ
Sbjct: 462 LAC--GDLCVPPEQLCDFEEQCAGGEDEQAC--GTTDFESPEAGGW-EDASVGRLQ---- 512
Query: 480 FRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPK 539
W +S + + + H + W G+ G A +LTP++ +GP
Sbjct: 513 --W---RRVSAQESQGSSAAAAGHFLSLQRAW--------GQLGAEARVLTPLLGPSGPS 559
Query: 540 CTL 542
C L
Sbjct: 560 CEL 562
Score = 187 bits (475), Expect = 7e-47
Identities = 173/677 (25%), Positives = 269/677 (39%), Gaps = 95/677 (14%)
Query: 422 CRSDGHCIEKMQKCDFKYDCPDKSDEASCVME----------VCSFEKRSLCKWYQPIPV 471
CRS G + C+F DC D SDEA C C FE+ C W
Sbjct: 28 CRSPGQAV-----CNFVCDCRDCSDEAQCGYHGASPTLGAPFACDFEQDP-CGW------ 75
Query: 472 HLLQDSNT--FRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADIL 529
+D +T + W + G H DHT T GWY+ + GK TA +
Sbjct: 76 ---RDISTSGYSWLRDRAGAALEGPGPHS---DHTLGTDLGWYMAVGTHRGKEASTAALR 129
Query: 530 TPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLG- 588
+P + C L W H V L+V + T LW TG G W+ V G
Sbjct: 130 SPTLREAASSCKLRLWYHAASGDVAELRVELTHGAETLTLWQSTGPWGPGWQELAVTTGR 189
Query: 589 IRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLC 648
IR ++ F A R ++ G VA+DD+ F DC L +P+ C C NK C+ +LC
Sbjct: 190 IRGDFRVTFSATRNATHRGAVALDDLEFWDCG-LPTPQANCPPGHHHCQNKVCVEPQQLC 248
Query: 649 DFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAAD 708
D ++C D SDE C DFE L W + E + N +A P + P D
Sbjct: 249 DGEDNCGDLSDENPLTCGRHIA-TDFETGLGPW--NRSEGWSRNHRAGG-PERPSWPRRD 304
Query: 709 HTLGNSSGHYIFINSLFPQQPMRAARISSPVI-SKRSKNCKIIFHYHMYGNGIGALTLMQ 767
H+ ++ G ++ + +P A +SSP + + NC ++F+ ++ G+ G L L
Sbjct: 305 HSRNSAQGSFL----VSVAEPGTPAILSSPEFQASGTSNCSLVFYQYLSGSEAGCLQLFL 360
Query: 768 VSV---TNQTKVLL-NLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIV 823
++ + VLL E G W R+ + + FQ+ G+ G G G + LDD++
Sbjct: 361 QTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILLAGQTGPG--GVVGLDDLI 418
Query: 824 LTENCLSLHDSVQEELAVPLPTG-----------------FCPLGYRECHNGKCYRLEQS 866
L+++C + + PLP G C G+ C C EQ
Sbjct: 419 LSDHCRPVS---EVSTLQPLPPGPRAPAPQPLPPSSRLQDSCKQGHLAC-GDLCVPPEQL 474
Query: 867 CNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDW--VLGVGSHQSLRPPKDHTLG 924
C+F + C E CG++ GW+++ W V S S H L
Sbjct: 475 CDFEEQCAGGEDEQACGTTDFESPEAGGWEDASVGRLQWRRVSAQESQGSSAAAAGHFLS 534
Query: 925 NENA---ILLMRRHKYPI-----RSVNLHTVKHVLKAQTVGNCS------------VSKL 964
+ A + R P+ S LH ++ +C+ +S
Sbjct: 535 LQRAWGQLGAEARVLTPLLGPSGPSCELHLAYYLQSQPREVSCNFERDTCSWYPGHLSDT 594
Query: 965 EARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFW 1024
R ++ +++T G HF+ L+ T G AH S ++ +SFW
Sbjct: 595 HWRWVESRGPDHDHTTGQG-----HFVLLDPTDPLAWGHSAHLLSRPQVPAAPTECLSFW 649
Query: 1025 YFISAKATGSIQILIKR 1041
Y + G++++ ++R
Sbjct: 650 YHLHGPQIGTLRLAMRR 666
Score = 140 bits (354), Expect = 7e-33
Identities = 148/603 (24%), Positives = 235/603 (38%), Gaps = 124/603 (20%)
Query: 208 LCDLVDDCGDRTDEVNC-----APEL----QCNFETGICNWEQDAKDDFDWTRNQGPTPT 258
+C+ V DC D +DE C +P L C+FE C W + + W R++
Sbjct: 35 VCNFVCDCRDCSDEAQCGYHGASPTLGAPFACDFEQDPCGWRDISTSGYSWLRDRAGAAL 94
Query: 259 LNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKR 318
GP D+TLGT G Y+ + + + +AAL SP L C R +YH
Sbjct: 95 EGPGPHSDHTLGTDLGWYMAVGTHRGKE-ASTAALRSPTLREA-ASSCKLRLWYHAASGD 152
Query: 319 IYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISS---RQPFQILVEASVGDGFTG 375
+ L + + + LWQ G G W + L +++ R F++ A+ G
Sbjct: 153 VAELRV--ELTHGAETLTLWQSTGPWGPGW--QELAVTTGRIRGDFRVTFSATRNATHRG 208
Query: 376 DIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKC 435
+A+DDL F DC LPTP NC C++ C+E Q C
Sbjct: 209 AVALDDLEFWDC---------GLPTPQA----------NCPPGHHHCQNK-VCVEPQQLC 248
Query: 436 DFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV--HLLQDSNTFRWGLGNGISIHHG 493
D + +C D SDE P+ H+ D F GLG
Sbjct: 249 DGEDNCGDLSDE-------------------NPLTCGRHIATD---FETGLGPWNRSEGW 286
Query: 494 EENHR---------PSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTG-PKCTLV 543
NHR P DH++N+ G +L S + G A + +P +G C+LV
Sbjct: 287 SRNHRAGGPERPSWPRRDHSRNSAQGSFLV---SVAEPGTPAILSSPEFQASGTSNCSLV 343
Query: 544 FWTHMNGATVGSLQVLIK-----KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFR 598
F+ +++G+ G LQ+ ++ L + G+ G W R V + QI+
Sbjct: 344 FYQYLSGSEAGCLQLFLQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILLA 403
Query: 599 AKRGISYIGDVAVDDISFQD-CSPL-----LSP-------------------ERKCTDHE 633
+ G G V +DD+ D C P+ L P + C
Sbjct: 404 GQTGPG--GVVGLDDLILSDHCRPVSEVSTLQPLPPGPRAPAPQPLPPSSRLQDSCKQGH 461
Query: 634 FMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF-DLCSWKQEKDEDFDWN 692
C + C+ ++LCDF CA DE + G DFE + W+ W
Sbjct: 462 LACGDL-CVPPEQLCDFEEQCAGGEDE------QACGTTDFESPEAGGWEDASVGRLQWR 514
Query: 693 LKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFH 752
+ S+ + G+ AA +GH++ + + Q AR+ +P++ +C++
Sbjct: 515 -RVSAQESQGSSAAA-------AGHFLSLQRAWGQLGAE-ARVLTPLLGPSGPSCELHLA 565
Query: 753 YHM 755
Y++
Sbjct: 566 YYL 568
Score = 103 bits (257), Expect = 1e-21
Identities = 95/401 (23%), Positives = 164/401 (40%), Gaps = 68/401 (16%)
Query: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
C FE + C + G W R + + A + PP DH+ +QGH+M + +
Sbjct: 734 CSFEDSDCGFSPGGQGL---WRRQANASGHAAW---GPPTDHTTETAQGHYMVVDTSPDA 787
Query: 79 L--WQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
L Q A L S L+FW++ S G + L H + + + G
Sbjct: 788 LPRGQTASLTSKEHRPLAQPACLTFWYHGSLRSPGTLRVYLEERGRHQ---VLSLSAHGG 844
Query: 137 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 196
W ++ + + + + + + V+ G+ A+DD+ ++ P P
Sbjct: 845 LAWRLGSMDV-QAERAWRVVFEAVAAGVAHSYVALDDLLLQDGPCPQPGS---------- 893
Query: 197 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDA---KDDFDWTRNQ 253
C+FE+G+C W A + W
Sbjct: 894 ---------------------------------CDFESGLCGWSHLAWPGLGGYSWDWGG 920
Query: 254 GPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYH 313
G TP+ P D+TLGT GH+ + E+ +A L S L AT RF+YH
Sbjct: 921 GATPSRYPQPPVDHTLGTEAGHFAFFETGVLGPGGRAAWLRSEPLPATPAS--CLRFWYH 978
Query: 314 M-FGKRIYRLAIYQRIWSDSRGQL-LWQIFGNQGNRWIRKHLNISSRQPFQILVEASV-G 370
M F + Y+ + + S ++GQL +W G++ ++W+ + ++S + FQI+ EA++ G
Sbjct: 979 MGFPEHFYKGELKVLLHS-AQGQLAVWGAGGHRRHQWLEAQVEVASAKEFQIVFEATLGG 1037
Query: 371 DGFTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLP 411
G IA+DD+ + L + P+P T+ P ++P
Sbjct: 1038 QPALGPIALDDVEY----LAGQHCQQPAPSPGNTAAPGSVP 1074
Score = 101 bits (252), Expect = 5e-21
Identities = 142/623 (22%), Positives = 219/623 (35%), Gaps = 151/623 (24%)
Query: 19 CDFEANSCDWFEA-ISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSS 77
C+FE ++C W+ +S H+ W+ S + P DH+ QGHF+ +
Sbjct: 577 CNFERDTCSWYPGHLSDTHWRWVES-----------RGPDHDHT--TGQGHFVLLDPTDP 623
Query: 78 SLW-QVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
W A L S P LSFW++ +G +G L+L M + T +W QG
Sbjct: 624 LAWGHSAHLLSRPQVPAAPTECLSFWYHLHGPQIGT--LRLAMRREGEETHLWSRSGTQG 681
Query: 137 KQWLEATIQLGRLSQP-FHLSLDKVSLGI---YDGVSAIDDIRFENCTLPLPAESCEGLD 192
+W EA L QP H + G+ Y G A+DD+ P P
Sbjct: 682 NRWHEAWATLSH--QPGSHAQYQLLFEGLRDGYHGTMALDDV----AVRPGP-------- 727
Query: 193 HFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRN 252
C C+FE C + + W R
Sbjct: 728 -------------------------------CWAPNYCSFEDSDCGFSPGGQG--LWRRQ 754
Query: 253 QGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYY 312
+ GP D+T TA+GHY+ +++S + A L+ + + F+Y
Sbjct: 755 ANASGHAAWGPPTDHTTETAQGHYMVVDTSPDALPRGQTASLTSKEHRPLAQPACLTFWY 814
Query: 313 HMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDG 372
H + L +Y + R Q+L + + G W +++ + + ++++ EA
Sbjct: 815 HGSLRSPGTLRVY--LEERGRHQVL-SLSAHGGLAWRLGSMDVQAERAWRVVFEAVAAGV 871
Query: 373 FTGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKM 432
+A+DDL L D P P S
Sbjct: 872 AHSYVALDDL-----------LLQDGPCPQPGS--------------------------- 893
Query: 433 QKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDS-NTFRWGLGNGISIH 491
CDF + LC W HL + W G G +
Sbjct: 894 --CDF---------------------ESGLCGW-----SHLAWPGLGGYSWDWGGGAT-- 923
Query: 492 HGEENHRPSVDHTQNTTDGWYLYADSS-NGKFGDTADILTPIISLTGPKCTLVFWTHMNG 550
+P VDHT T G + + ++ G G A + + + T C L FW HM
Sbjct: 924 -PSRYPQPPVDHTLGTEAGHFAFFETGVLGPGGRAAWLRSEPLPATPASC-LRFWYHMGF 981
Query: 551 AT---VGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAK-RGISYI 606
G L+VL+ +W G + QW A+V + QIVF A G +
Sbjct: 982 PEHFYKGELKVLLHSAQGQLAVWGAGGHRRHQWLEAQVEVASAKEFQIVFEATLGGQPAL 1041
Query: 607 GDVAVDDISF---QDC-SPLLSP 625
G +A+DD+ + Q C P SP
Sbjct: 1042 GPIALDDVEYLAGQHCQQPAPSP 1064
Score = 101 bits (251), Expect = 6e-21
Identities = 149/631 (23%), Positives = 230/631 (36%), Gaps = 108/631 (17%)
Query: 640 HCIAKDK-LCDFVNDCADNSDETTFICRTSSGR------CDFEFDLCSWKQEKDEDFDWN 692
HC + + +C+FV DC D SDE +S CDFE D C W+ + W
Sbjct: 27 HCRSPGQAVCNFVCDCRDCSDEAQCGYHGASPTLGAPFACDFEQDPCGWRDISTSGYSWL 86
Query: 693 LKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFH 752
+ G P +DHTLG G Y+ + + ++ AA + SP + + + +CK+
Sbjct: 87 RDRAGAALEGPGPHSDHTLGTDLGWYMAVGTHRGKEASTAA-LRSPTLREAASSCKLRLW 145
Query: 753 YHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDE---DFQLKFEGRV 809
YH + L + +++ +T L T G W +EL++ DF++ F
Sbjct: 146 YHAASGDVAELRV-ELTHGAETLTLWQSTGPWGPGW--QELAVTTGRIRGDFRVTFSATR 202
Query: 810 GKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNF 869
RG +ALDD+ + +P P CP G+ C N C +Q C+
Sbjct: 203 NATHRGAVALDDLEFWD------------CGLPTPQANCPPGHHHCQNKVCVEPQQLCD- 249
Query: 870 VDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRPPKDHTLGNENAI 929
GE+ CG CG A +F+ LG + +S ++H G
Sbjct: 250 --------GEDNCGDLSDENPLTCG--RHIATDFETGLGPWN-RSEGWSRNHRAGGPE-- 296
Query: 930 LLMRRHKYPIRSVNLHTVKHVLKAQTVGNCSVSKLEARLLDFLSVPNENTFGSSDHMNWH 989
R +P R + ++ + G+ VS E LS P G+S+
Sbjct: 297 ----RPSWPRRDHSRNSAQ--------GSFLVSVAEPGTPAILSSPEFQASGTSNCSLVF 344
Query: 990 FMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQILIKR----GRRR 1045
+ YL S A C F + A + +L +R G
Sbjct: 345 YQYLSG-------------------SEAGCLQLFLQTLGPGAPRAPVLLRRRRGELGTAW 385
Query: 1046 RRAPNPVLSGSP-TIPRQGSQQLGGWRGGS---ARHRARAFPEPECPRGRSALLKGPPQE 1101
R + S P I G GG G R E S L PP
Sbjct: 386 VRDRVDIQSAYPFQILLAGQTGPGGVVGLDDLILSDHCRPVSEV------STLQPLPPGP 439
Query: 1102 EPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTT 1161
L + + C + C D C+ LCD++ C+G DE C
Sbjct: 440 RAPAPQPLPPSSRLQDSCKQ-GHLACGDL-CVPPEQLCDFEEQCAGGEDEQAC------- 490
Query: 1162 GSCNFET-SSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1220
G+ +FE+ +G W A S L W R+ A+ S G HFL + +
Sbjct: 491 GTTDFESPEAGGWEDA------SVGRLQW---RRVSAQESQGSSAAAAG---HFLSLQRA 538
Query: 1221 GSKEGSVARITTSKSFPASLGMCTVRFWFYM 1251
+ G+ AR+ T P+ C + +Y+
Sbjct: 539 WGQLGAEARVLTPLLGPSG-PSCELHLAYYL 568
Score = 92.0 bits (227), Expect = 4e-18
Identities = 109/483 (22%), Positives = 179/483 (37%), Gaps = 131/483 (27%)
Query: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 514
C+FE R C WY P HL +RW E+ P DHT T G ++
Sbjct: 577 CNFE-RDTCSWY---PGHL--SDTHWRW-----------VESRGPDHDHT--TGQGHFVL 617
Query: 515 ADSSNG-KFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQT 573
D ++ +G +A +L+ P L FW H++G +G+L++ ++++ + LW+++
Sbjct: 618 LDPTDPLAWGHSAHLLSRPQVPAAPTECLSFWYHLHGPQIGTLRLAMRREGEETHLWSRS 677
Query: 574 GQQGAQWKRAEVFL----GIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKC 629
G QG +W A L G + Q++F R Y G +A+DD++ + P +P
Sbjct: 678 GTQGNRWHEAWATLSHQPGSHAQYQLLFEGLRD-GYHGTMALDDVAVRP-GPCWAP---- 731
Query: 630 TDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDF 689
+C +D C F S G
Sbjct: 732 ---------NYCSFEDSDCGF-----------------SPGGQGL--------------- 750
Query: 690 DWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPM-RAARISSPVISKRSKNCK 748
W +A++ A P DHT + GHY+ +++ P + A ++S ++
Sbjct: 751 -WRRQANASGHAAWGPPTDHTTETAQGHYMVVDTSPDALPRGQTASLTSKEHRPLAQPAC 809
Query: 749 IIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGR 808
+ F YH G+ TL +L+L+ G WR + + + +++ FE
Sbjct: 810 LTFWYH--GSLRSPGTLRVYLEERGRHQVLSLSAHGGLAWRLGSMDVQAERAWRVVFEAV 867
Query: 809 VGKGQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCN 868
+ALDD++L + G CP
Sbjct: 868 AAGVAHSYVALDDLLLQD-------------------GPCPQ------------------ 890
Query: 869 FVDNCGDNTGENKCGSSCTFEKGWCGWQNSQ-----ADNFDWVLGVGSHQSLRPPKDHTL 923
SC FE G CGW + ++DW G + +PP DHTL
Sbjct: 891 --------------PGSCDFESGLCGWSHLAWPGLGGYSWDWGGGATPSRYPQPPVDHTL 936
Query: 924 GNE 926
G E
Sbjct: 937 GTE 939
Score = 73.9 bits (180), Expect = 1e-12
Identities = 52/162 (32%), Positives = 81/162 (50%), Gaps = 18/162 (11%)
Query: 227 ELQCNFETGICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQA 286
E+ CNFE C+W D W + + GP D+T T +GH++ ++ ++P A
Sbjct: 574 EVSCNFERDTCSWYPGHLSDTHWRWVE------SRGPDHDHT--TGQGHFVLLDPTDPLA 625
Query: 287 FQDSAALLS-PILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQG 345
+ SA LLS P + A T+ F+YH+ G +I L + R + LW G QG
Sbjct: 626 WGHSAHLLSRPQVPAAPTE--CLSFWYHLHGPQIGTLRLAMR--REGEETHLWSRSGTQG 681
Query: 346 NRWIRKHLNIS----SRQPFQILVEASVGDGFTGDIAIDDLS 383
NRW +S S +Q+L E + DG+ G +A+DD++
Sbjct: 682 NRWHEAWATLSHQPGSHAQYQLLFE-GLRDGYHGTMALDDVA 722
Score = 73.6 bits (179), Expect = 1e-12
Identities = 78/336 (23%), Positives = 125/336 (37%), Gaps = 63/336 (18%)
Query: 499 PSVDHTQNTTDGWYLYADSSNGKF--GDTADILTPIISLTGPKCTLVFWTHMNGATVGSL 556
P DHT T G Y+ D+S G TA + + L FW H + + G+L
Sbjct: 765 PPTDHTTETAQGHYMVVDTSPDALPRGQTASLTSKEHRPLAQPACLTFWYHGSLRSPGTL 824
Query: 557 QVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISF 616
+V +++ ++ + + G W+ + + ++VF A VA+DD+
Sbjct: 825 RVYLEERG-RHQVLSLSAHGGLAWRLGSMDVQAERAWRVVFEAVAAGVAHSYVALDDLLL 883
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
QD P P G CDFE
Sbjct: 884 QD-GPCPQP--------------------------------------------GSCDFES 898
Query: 677 DLCSWKQEKDED---FDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAA 733
LC W + W+ + P+ +P DHTLG +GH+ F + RAA
Sbjct: 899 GLCGWSHLAWPGLGGYSWDWGGGATPSRYPQPPVDHTLGTEAGHFAFFETGVLGPGGRAA 958
Query: 734 RISSPVISKRSKNCKIIFHYHMYGNGI------GALTLMQVSVTNQTKVLLNLTVEQGNF 787
+ S + +C + F YHM G G L ++ S Q V + +
Sbjct: 959 WLRSEPLPATPASC-LRFWYHM---GFPEHFYKGELKVLLHSAQGQLAV-WGAGGHRRHQ 1013
Query: 788 WRREELSLFGDEDFQLKFEGRV-GKGQRGDIALDDI 822
W ++ + ++FQ+ FE + G+ G IALDD+
Sbjct: 1014 WLEAQVEVASAKEFQIVFEATLGGQPALGPIALDDV 1049
Score = 65.5 bits (158), Expect = 4e-10
Identities = 54/177 (30%), Positives = 77/177 (43%), Gaps = 10/177 (5%)
Query: 1162 GSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS-GQHFLYVNSS 1220
GSC+FE+ W+ DW G P++ P DHT G+ HF + +
Sbjct: 892 GSCDFESGLCGWSHLAWPGLGGYS-WDWG-GGATPSRYPQPPVDHTLGTEAGHFAFFETG 949
Query: 1221 GSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSM--GILKVYTIEESGLNILVWSVI 1278
G A S+ PA+ C +RFW++M P G LKV G + VW
Sbjct: 950 VLGPGGRAAWLRSEPLPATPASC-LRFWYHMGFPEHFYKGELKVLLHSAQG-QLAVWGAG 1007
Query: 1279 GNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIF-IALDDISFT--PECVTGGPVP 1332
G++R W V ++S F++ FEA L G + IALDD+ + C P P
Sbjct: 1008 GHRRHQWLEAQVEVASAKEFQIVFEATLGGQPALGPIALDDVEYLAGQHCQQPAPSP 1064
Score = 61.6 bits (148), Expect = 6e-09
Identities = 61/240 (25%), Positives = 98/240 (40%), Gaps = 21/240 (8%)
Query: 1138 LCDYKPDCSGRSDEAHCAHY--TSTTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIG 1192
+C++ DC SDEA C ++ + T G +C+FE W ++ L G
Sbjct: 35 VCNFVCDCRDCSDEAQCGYHGASPTLGAPFACDFEQDPCGWR---DISTSGYSWLRDRAG 91
Query: 1193 SRIPAKALIPDSDHTPGSG-QHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYM 1251
+ + P SDHT G+ ++ V + KE S A + S + + C +R W++
Sbjct: 92 AALEGPG--PHSDHTLGTDLGWYMAVGTHRGKEASTAAL-RSPTLREAASSCKLRLWYHA 148
Query: 1252 IDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSS-NSPFKVAFEADLDGNE 1310
+ L+V + + +W G GW +V F+V F A +
Sbjct: 149 AS-GDVAELRV-ELTHGAETLTLWQSTGPWGPGWQELAVTTGRIRGDFRVTFSATRNATH 206
Query: 1311 DIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE 1370
+ALDD+ F +C +P + C C CV CDG ++C D SDE
Sbjct: 207 RGAVALDDLEFW-DC----GLPTPQANCPPGHHHC-QNKVCVEPQQLCDGEDNCGDLSDE 260
Score = 59.3 bits (142), Expect = 3e-08
Identities = 98/437 (22%), Positives = 155/437 (35%), Gaps = 86/437 (19%)
Query: 976 NENTFGSSDHMNWHFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSI 1035
+++T G+ + W+ T G A RS RE++++C + WY ++ +
Sbjct: 101 SDHTLGTD--LGWYMAV--GTHRGKEASTAALRSPTLREAASSCKLRLWYHAASGDVAEL 156
Query: 1036 QILIKRGRRRRRAPNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALL 1095
++ + G A L S G Q+L G F R A+
Sbjct: 157 RVELTHG-----AETLTLWQSTGPWGPGWQELAVTTGRIRGDFRVTFSATRNATHRGAVA 211
Query: 1096 K--------GPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSG 1147
G P + N CP C++K C+ LCD + +C
Sbjct: 212 LDDLEFWDCGLPTPQAN--------------CPP-GHHHCQNKVCVEPQQLCDGEDNCGD 256
Query: 1148 RSDE--AHCAHYTSTTGSCNFETSSGNWTTACSLTQDSEDDLDWAIGSRI--PAKALIPD 1203
SDE C + +T +FET G W + W+ R P + P
Sbjct: 257 LSDENPLTCGRHIAT----DFETGLGPWNRSEG----------WSRNHRAGGPERPSWPR 302
Query: 1204 SDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPAS-LGMCTVRFWFYMIDPRSMGILKV 1262
DH+ S Q V+ + E I +S F AS C++ F+ Y+ + G L++
Sbjct: 303 RDHSRNSAQGSFLVSVA---EPGTPAILSSPEFQASGTSNCSLVFYQYLSGSEA-GCLQL 358
Query: 1263 YTIEESGLN-----ILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALD 1317
+ ++ G +L+ G T W V + S PF++ A G + + LD
Sbjct: 359 F-LQTLGPGAPRAPVLLRRRRGELGTAWVRDRVDIQSAYPFQILL-AGQTGPGGV-VGLD 415
Query: 1318 DISFTPEC-----------VTGGPVPVQPSP----------CEADQFSCIYTLQCVPLSG 1356
D+ + C + GP P P C+ +C CVP
Sbjct: 416 DLILSDHCRPVSEVSTLQPLPPGPRAPAPQPLPPSSRLQDSCKQGHLACGDL--CVPPEQ 473
Query: 1357 KCDGHEDCIDGSDEMDC 1373
CD E C G DE C
Sbjct: 474 LCDFEEQCAGGEDEQAC 490
Score = 57.8 bits (138), Expect = 8e-08
Identities = 44/147 (29%), Positives = 70/147 (47%), Gaps = 13/147 (8%)
Query: 1202 PDSDHTPGSGQ-HFLYVNSSGSK--EGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMG 1258
P +DHT + Q H++ V++S G A +T+ + P + C + FW++ RS G
Sbjct: 765 PPTDHTTETAQGHYMVVDTSPDALPRGQTASLTSKEHRPLAQPAC-LTFWYHG-SLRSPG 822
Query: 1259 ILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDD 1318
L+VY E +L S G W GS+ + + ++V FEA G ++ALDD
Sbjct: 823 TLRVYLEERGRHQVLSLSAHGG--LAWRLGSMDVQAERAWRVVFEAVAAGVAHSYVALDD 880
Query: 1319 ISFTPECVTGGPVPVQPSPCEADQFSC 1345
+ + GP P QP C+ + C
Sbjct: 881 L-----LLQDGPCP-QPGSCDFESGLC 901
Score = 56.2 bits (134), Expect = 2e-07
Identities = 56/213 (26%), Positives = 86/213 (40%), Gaps = 34/213 (15%)
Query: 1146 SGRSDEAHCAHYTSTTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIP 1202
SG S E H A+Y + SCNFE + CS D W ++ P
Sbjct: 556 SGPSCELHLAYYLQSQPREVSCNFERDT------CSWYPGHLSDTHWRW-----VESRGP 604
Query: 1203 DSDHTPGSGQHFLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKV 1262
D DHT G G L + G A + + PA+ C + FW+++ P+ +G L++
Sbjct: 605 DHDHTTGQGHFVLLDPTDPLAWGHSAHLLSRPQVPAAPTEC-LSFWYHLHGPQ-IGTLRL 662
Query: 1263 YTIEESGLNILVWSVIGNKRTGWTYGSVPLS----SNSPFKVAFEADLDGNEDIFIALDD 1318
+ G +WS G + W LS S++ +++ FE DG +ALDD
Sbjct: 663 -AMRREGEETHLWSRSGTQGNRWHEAWATLSHQPGSHAQYQLLFEGLRDGYHGT-MALDD 720
Query: 1319 ISFTPECVTGGPVPVQPSPCEADQFSCIYTLQC 1351
++ V+P PC A + C
Sbjct: 721 VA------------VRPGPCWAPNYCSFEDSDC 741
Score = 33.1 bits (74), Expect = 2.1
Identities = 30/124 (24%), Positives = 46/124 (37%), Gaps = 21/124 (16%)
Query: 20 DFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSSL 79
DFE+ +E S W R S E S A+ GHF+ + + L
Sbjct: 494 DFESPEAGGWEDASVGRLQWRRVSAQESQG-----------SSAAAAGHFLSLQRAWGQL 542
Query: 80 WQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMEN-------SHDSTVIWRVL 132
A++ +P +GP C L +Y L E+ + E H S WR +
Sbjct: 543 GAEARVLTPLLGPSGPSCELHLAYY---LQSQPREVSCNFERDTCSWYPGHLSDTHWRWV 599
Query: 133 YNQG 136
++G
Sbjct: 600 ESRG 603
>gi|24111244 MAM domain containing glycosylphosphatidylinositol
anchor 1 [Homo sapiens]
Length = 955
Score = 124 bits (312), Expect = 5e-28
Identities = 81/199 (40%), Positives = 111/199 (55%), Gaps = 21/199 (10%)
Query: 219 TDEVNCAPELQ---CNFETG-ICNWEQDAKDDFDWTRN----QGPTPTLNTGPMKDNTLG 270
T+ +N +P L C+FE IC + QD D+FDWTR Q P + NTGP D + G
Sbjct: 740 TEPIN-SPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-G 797
Query: 271 TAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWS 330
T +G+Y++IE+S P+ D A L+SP+ NA+ C F+YHM+GK I L + R S
Sbjct: 798 TPEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCV-SFFYHMYGKHIGSLNLLVR--S 854
Query: 331 DSRGQL---LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDC 387
++G L W + GN+GN W + H+ IS PFQI+ E G G+ GDIAIDD+
Sbjct: 855 RNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDV----- 909
Query: 388 TLYPGNLPADLPTPPETSV 406
TL G P P + V
Sbjct: 910 TLKKGECPRKQTDPNKVVV 928
Score = 85.1 bits (209), Expect = 5e-16
Identities = 55/167 (32%), Positives = 88/167 (52%), Gaps = 14/167 (8%)
Query: 668 SSGRCDFEFD-LCSWKQEKDEDFDWN----LKASSIPAAGTEPAADHTLGNSSGHYIFIN 722
S C FE + +C + Q+ ++FDW L + + T P D + G G+Y+FI
Sbjct: 749 SDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTPEGYYMFIE 807
Query: 723 SLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLL---- 778
+ P++ AR+ SP+ + +K + F YHMYG IG+L L+ V ++ K L
Sbjct: 808 TSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLL---VRSRNKGALDTHA 864
Query: 779 -NLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVL 824
+L+ +GN W++ + + FQ+ FEG G G GDIA+DD+ L
Sbjct: 865 WSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
Score = 79.7 bits (195), Expect = 2e-14
Identities = 42/167 (25%), Positives = 85/167 (50%), Gaps = 11/167 (6%)
Query: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 514
C FE +C + Q + ++ F W N ++ + + T +G+Y++
Sbjct: 753 CHFEDEKICGYTQDL-------TDNFDWTRQNALTQNPKRSPNTGPPTDISGTPEGYYMF 805
Query: 515 ADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDN---VTSKLW 570
++S + GD A +++P+ + + + F+ HM G +GSL +L++ N + + W
Sbjct: 806 IETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGALDTHAW 865
Query: 571 AQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQ 617
+ +G +G W++A V + QI+F RG Y+GD+A+DD++ +
Sbjct: 866 SLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLK 912
Score = 59.7 bits (143), Expect = 2e-08
Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 5/179 (2%)
Query: 7 EILSSMKIWVSKCDFEANSCDWFEAISGDHFDWIRSSQ-SELSADFEHQAPPRDHSLNAS 65
E ++S + + C FE + D+FDW R + ++ + PP D S
Sbjct: 741 EPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDIS-GTP 799
Query: 66 QGHFMFI-LKKSSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHD 124
+G++MFI + L A+L SP ++ + +SF+++ YG +G+ L + N
Sbjct: 800 EGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRNKGA 859
Query: 125 -STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLP 182
T W + N+G W +A + + S PF + + V Y G AIDD+ + P
Sbjct: 860 LDTHAWSLSGNKGNVWQQAHVPISP-SGPFQIIFEGVRGPGYLGDIAIDDVTLKKGECP 917
Score = 58.5 bits (140), Expect = 5e-08
Identities = 54/209 (25%), Positives = 87/209 (41%), Gaps = 33/209 (15%)
Query: 1156 HYTSTTGSCNFETSSGNWTTA--CSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ- 1212
HYT S N ++ ++ C TQD D+ DW AL + +P +G
Sbjct: 738 HYTEPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWT-----RQNALTQNPKRSPNTGPP 792
Query: 1213 ---------HFLYVNSSGSKE-GSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGI-LK 1261
+++++ +S +E G AR+ S + AS V F+++M + L
Sbjct: 793 TDISGTPEGYYMFIETSRPRELGDRARLV-SPLYNASAKFYCVSFFYHMYGKHIGSLNLL 851
Query: 1262 VYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1321
V + + L+ WS+ GNK W VP+S + PF++ FE IA+DD++
Sbjct: 852 VRSRNKGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTL 911
Query: 1322 TP-EC------------VTGGPVPVQPSP 1337
EC + G P Q SP
Sbjct: 912 KKGECPRKQTDPNKVVVMPGSGAPCQSSP 940
Score = 32.7 bits (73), Expect = 2.8
Identities = 14/52 (26%), Positives = 30/52 (57%)
Query: 989 HFMYLEATAVGLRGDKAHFRSTMWRESSAACTMSFWYFISAKATGSIQILIK 1040
++M++E + GD+A S ++ S+ +SF+Y + K GS+ +L++
Sbjct: 802 YYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVR 853
>gi|223278413 MAM domain containing 2 [Homo sapiens]
Length = 686
Score = 120 bits (300), Expect = 1e-26
Identities = 143/629 (22%), Positives = 237/629 (37%), Gaps = 142/629 (22%)
Query: 228 LQCNFETG-ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQA 286
++C+FE +C + + +W G +++ +D+T + GHY+Y++S +
Sbjct: 168 IECDFEENHLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSELGHYMYVDSVYVKH 227
Query: 287 FQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRL------AIYQRIW-SDSRGQLLWQ 339
FQ+ A L+SP+ A +F + ++ L +Y+ IW +D G W
Sbjct: 228 FQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEEIWKADRPGNAAWN 287
Query: 340 IFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLP 399
+ + S+ P +++ E + G +A+DD+SF
Sbjct: 288 L----------AEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFS-------------- 323
Query: 400 TPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEK 459
P H E + S V C+FE+
Sbjct: 324 -----------PVHCQNQTELLF--------------------------SAVEASCNFEQ 346
Query: 460 RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSN 519
LC +YQ G G + + N + DHT T G+YL A N
Sbjct: 347 -DLCNFYQDKE--------------GPGWTRVKVKPNMYRAGDHT--TGLGYYLLA---N 386
Query: 520 GKFGDTADILTPIISLTGPKCTLVFWTHMNGATVG------SLQVLIKKDN--VTSKLWA 571
KF + + + P L + + A G +L V I ++N V K+W+
Sbjct: 387 TKFTSQPGYIGRLYGPSLPG-NLQYCLRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWS 445
Query: 572 QTGQQGAQWKRAEVFLGIRSHTQIVFRAK-RGISYIGDVAVDDISFQDCSPLLSPERKCT 630
W +AE+ T++VF + + G VA+DDI+ Q S
Sbjct: 446 VLESPRGVWMQAEITFKKPMPTKVVFMSLCKSFWDCGLVALDDITIQLGS---------- 495
Query: 631 DHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEKDEDFD 690
C + +KL G C FE D C++ QEK
Sbjct: 496 ----------CSSSEKL------------------PPPPGECTFEQDECTFTQEKRNRSS 527
Query: 691 WNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKII 750
W+ + P + T P DHT G G+Y++I + +A +S P+ K+C +
Sbjct: 528 WHRRRGETPTSYTGPKGDHTTG--VGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LT 584
Query: 751 FHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDFQLKFEGRV 809
F YHMYG G G L++ ++ ++ +L EQ W R + + Q+ FE
Sbjct: 585 FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIR 644
Query: 810 GKGQRGDIALDDIVLTEN-CLSLHDSVQE 837
G R DIA+DD+ C + D+ Q+
Sbjct: 645 GVSIRSDIAIDDVKFQAGPCGEMEDTTQQ 673
Score = 119 bits (297), Expect = 3e-26
Identities = 139/606 (22%), Positives = 231/606 (38%), Gaps = 120/606 (19%)
Query: 18 KCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSS 77
+CDFE N F + +W S + H P+DH+ + GH+M++
Sbjct: 169 ECDFEENHLCGFVNRWNPNVNWFVGGGSIRNV---HSILPQDHTFKSELGHYMYVDSVYV 225
Query: 78 SLWQ-VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQG 136
+Q VA+L SP + GC+ ++ G + + ++ IW+
Sbjct: 226 KHFQEVAQLISPLTTAPMAGCLSFYYQIQQGNDNVFSLYTRDVAGLYEE--IWKADRPGN 283
Query: 137 KQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWC 196
W A ++ P + + G G A+DDI F
Sbjct: 284 AAWNLAEVEFSA-PYPMEVIFEVAFNGPKGGYVALDDISFSPV----------------- 325
Query: 197 RHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPT 256
C ++T+ + A E CNFE +CN+ QD K+ WTR +
Sbjct: 326 -----------------HCQNQTELLFSAVEASCNFEQDLCNFYQD-KEGPGWTRVKVKP 367
Query: 257 PTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFG 316
G D+T G G+YL + L P L + + C RF+Y ++G
Sbjct: 368 NMYRAG---DHTTGL--GYYLLANTKFTSQPGYIGRLYGPSLPG-NLQYC-LRFHYAIYG 420
Query: 317 --KRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFT 374
K LA+Y + + +W + + W++ + P +++ +
Sbjct: 421 FLKMSDTLAVYIFEENHVVQEKIWSVLESPRGVWMQAEITFKKPMPTKVVFMSLC----- 475
Query: 375 GDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQK 434
SF DC L + +T+ +C+ +E + G C + +
Sbjct: 476 -------KSFWDCGLVALD-------------DITIQLGSCSSSEKLPPPPGECTFEQDE 515
Query: 435 CDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGE 494
C F + EKR+ W++ G + + G
Sbjct: 516 CTF------------------TQEKRNRSSWHR---------------RRGETPTSYTG- 541
Query: 495 ENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILT-PIISLTGPKCTLVFWTHMNGATV 553
P DHT T G+Y+Y ++S+ +G A +L+ P+ ++G C L F+ HM G
Sbjct: 542 ----PKGDHT--TGVGYYMYIEASHMVYGQKARLLSRPLRGVSGKHC-LTFFYHMYGGGT 594
Query: 554 GSLQVLIKK--DNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAV 611
G L V +KK D+ S LW + G+Q W RA + QI+F A RG+S D+A+
Sbjct: 595 GLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAI 654
Query: 612 DDISFQ 617
DD+ FQ
Sbjct: 655 DDVKFQ 660
Score = 109 bits (273), Expect = 2e-23
Identities = 100/372 (26%), Positives = 156/372 (41%), Gaps = 56/372 (15%)
Query: 17 SKCDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKK- 75
+ C+FE + C++++ G + ++ + A DH+ G+++ K
Sbjct: 340 ASCNFEQDLCNFYQDKEGPGWTRVKVKPNMYRAG--------DHTTGL--GYYLLANTKF 389
Query: 76 SSSLWQVAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHM--ENSHDSTVIWRVLY 133
+S + +L P+ C L F + YG + L +++ EN IW VL
Sbjct: 390 TSQPGYIGRLYGPSLPGNLQYC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLE 448
Query: 134 NQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYD-GVSAIDDIRFENCTLPLPAESCEGLD 192
+ W++A I + P + + +D G+ A+DDI + SC
Sbjct: 449 SPRGVWMQAEITFKK-PMPTKVVFMSLCKSFWDCGLVALDDITIQ-------LGSCSSS- 499
Query: 193 HFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRN 252
EKL P +C FE C + Q+ ++ W R
Sbjct: 500 -----------EKLP-----------------PPPGECTFEQDECTFTQEKRNRSSWHRR 531
Query: 253 QGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYY 312
+G TPT TGP D+T G G+Y+YIE+S + A LLS L K C F+Y
Sbjct: 532 RGETPTSYTGPKGDHTTGV--GYYMYIEASH-MVYGQKARLLSRPLRGVSGKHC-LTFFY 587
Query: 313 HMFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDG 372
HM+G L++Y + DS LLW+ G Q W+R + S + QI+ EA G
Sbjct: 588 HMYGGGTGLLSVYLKKEEDSEESLLWRRRGEQSISWLRALIEYSCERQHQIIFEAIRGVS 647
Query: 373 FTGDIAIDDLSF 384
DIAIDD+ F
Sbjct: 648 IRSDIAIDDVKF 659
Score = 85.9 bits (211), Expect = 3e-16
Identities = 133/595 (22%), Positives = 223/595 (37%), Gaps = 139/595 (23%)
Query: 273 KGHYLYIESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIY---RLAIYQRIW 329
+GHY+Y+++S + + A LLSP L A + + + + +L +Y R
Sbjct: 49 EGHYIYVDTSFGKQ-GEKAVLLSPDLQAEEWSCLRLVYQITTSSESLSDPSQLNLYMRFE 107
Query: 330 SDSRGQLLWQIFGNQGNRWIRKHLNI-SSRQPFQILVEASVGDGFTGDIAIDDLSFMDCT 388
+S +LLW + W+ L++ +S + F+IL+E +G G T IA+ ++
Sbjct: 108 DESFDRLLWSA-KEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIALFEIKM---- 162
Query: 389 LYPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA 448
+ G+CIE CDF+ +
Sbjct: 163 -----------------------------------TTGYCIE----CDFEEN-------- 175
Query: 449 SCVMEVCSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTT 508
+C F R W + W +G G SI + + P DHT +
Sbjct: 176 ----HLCGFVNR----WNPNV-----------NWFVGGG-SIRN-VHSILPQ-DHTFKSE 213
Query: 509 DGWYLYADSSNGK-FGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKD--NV 565
G Y+Y DS K F + A +++P+ + C ++ G ++ L +D +
Sbjct: 214 LGHYMYVDSVYVKHFQEVAQLISPLTTAPMAGCLSFYYQIQQGND--NVFSLYTRDVAGL 271
Query: 566 TSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSP 625
++W A W AEV +++F G VA+DDISF SP+
Sbjct: 272 YEEIWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISF---SPV--- 325
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQEK 685
HC ++T + C+FE DLC++ Q+K
Sbjct: 326 --------------HC----------------QNQTELLFSAVEASCNFEQDLCNFYQDK 355
Query: 686 DEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSK 745
+ +K A DHT G G+Y+ N+ F QP R+ P + +
Sbjct: 356 EGPGWTRVKVK----PNMYRAGDHTTG--LGYYLLANTKFTSQPGYIGRLYGPSLPGNLQ 409
Query: 746 NCKIIFHYHMYG----NGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSLFGDEDF 801
C + FHY +YG + A+ + + + Q K+ L +G W + E++
Sbjct: 410 YC-LRFHYAIYGFLKMSDTLAVYIFEENHVVQEKIWSVLESPRG-VWMQAEITFKKPMPT 467
Query: 802 QLKFEGRVGK-GQRGDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYREC 855
++ F G +ALDDI + S + +P P G C EC
Sbjct: 468 KVVFMSLCKSFWDCGLVALDDITIQLGSCSSSEK------LPPPPGECTFEQDEC 516
Score = 56.6 bits (135), Expect = 2e-07
Identities = 46/170 (27%), Positives = 74/170 (43%), Gaps = 14/170 (8%)
Query: 1160 TTG---SCNFETSSGNWTTACSLTQDSEDDLDWAIG--SRIPAKALIPDSDHTPGSGQ-H 1213
TTG C+FE + C +++W +G S +++P DHT S H
Sbjct: 163 TTGYCIECDFEENH-----LCGFVNRWNPNVNWFVGGGSIRNVHSILPQ-DHTFKSELGH 216
Query: 1214 FLYVNSSGSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNIL 1273
++YV+S K S A + C ++Y I + + +YT + +GL
Sbjct: 217 YMYVDSVYVKHFQEVAQLISPLTTAPMAGCLS--FYYQIQQGNDNVFSLYTRDVAGLYEE 274
Query: 1274 VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP 1323
+W W V S+ P +V FE +G + ++ALDDISF+P
Sbjct: 275 IWKADRPGNAAWNLAEVEFSAPYPMEVIFEVAFNGPKGGYVALDDISFSP 324
Score = 51.6 bits (122), Expect = 6e-06
Identities = 43/162 (26%), Positives = 64/162 (39%), Gaps = 11/162 (6%)
Query: 1162 GSCNFETSSGNWTTACSLTQDSEDDLDW-AIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1220
G C FE C+ TQ+ + W P P DHT G G +++Y+ +S
Sbjct: 507 GECTFEQDE------CTFTQEKRNRSSWHRRRGETPTSYTGPKGDHTTGVG-YYMYIEAS 559
Query: 1221 GSKEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTI-EESGLNILVWSVIG 1279
G AR+ + S C +FY + G+L VY EE L+W G
Sbjct: 560 HMVYGQKARLLSRPLRGVSGKHCLT--FFYHMYGGGTGLLSVYLKKEEDSEESLLWRRRG 617
Query: 1280 NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISF 1321
+ W + S ++ FEA + IA+DD+ F
Sbjct: 618 EQSISWLRALIEYSCERQHQIIFEAIRGVSIRSDIAIDDVKF 659
Score = 39.7 bits (91), Expect = 0.023
Identities = 48/230 (20%), Positives = 89/230 (38%), Gaps = 79/230 (34%)
Query: 713 NSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTN 772
N GHYI++++ F +Q +A +S + ++ ++++ +T S+++
Sbjct: 47 NEEGHYIYVDTSFGKQGEKAVLLSPDLQAEEWSCLRLVYQ----------ITTSSESLSD 96
Query: 773 QTKVLLNLTVEQGNF----WRREELS---LFGDED-------FQLKFEGRVGKGQRGDIA 818
+++ L + E +F W +E S L D F++ EG +G+G IA
Sbjct: 97 PSQLNLYMRFEDESFDRLLWSAKEPSDSWLIASLDLQNSSKKFKILIEGVLGQGNTASIA 156
Query: 819 LDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTG 878
L +I +T TG+C C+F +N
Sbjct: 157 LFEIKMT-------------------TGYC----------------IECDFEEN------ 175
Query: 879 ENKCGSSCTFEKGWCGWQNSQADNFDWVLGVGSHQSLRP--PKDHTLGNE 926
CG+ N N +W +G GS +++ P+DHT +E
Sbjct: 176 ------------HLCGFVNRWNPNVNWFVGGGSIRNVHSILPQDHTFKSE 213
>gi|164698517 MAM domain containing 1 isoform 1 [Homo sapiens]
Length = 956
Score = 116 bits (291), Expect = 1e-25
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 227 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 281
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 745 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 803
Query: 282 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 333
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 804 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 858
Query: 334 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 386
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 859 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
Score = 78.2 bits (191), Expect = 6e-14
Identities = 55/172 (31%), Positives = 86/172 (50%), Gaps = 20/172 (11%)
Query: 672 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFINSLFP 726
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I + P
Sbjct: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 806
Query: 727 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 776
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 807 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 864
Query: 777 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 826
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 865 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
Score = 69.3 bits (168), Expect = 3e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 513
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 748 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 799
Query: 514 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 561
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 800 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 859
Query: 562 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 618
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 860 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 916
Score = 55.1 bits (131), Expect = 5e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 748 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 807
Query: 79 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 128
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 808 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 867
Query: 129 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 174
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 868 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 912
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 1164 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1218
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 748 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 802
Query: 1219 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1269
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 803 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 860
Query: 1270 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1325
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 861 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 919
>gi|38158013 MAM domain containing 1 isoform 2 [Homo sapiens]
Length = 727
Score = 116 bits (291), Expect = 1e-25
Identities = 72/178 (40%), Positives = 97/178 (54%), Gaps = 24/178 (13%)
Query: 227 ELQCNFETG-ICNWEQDAKDDFDWTRNQGPTP----TLNTGPMKDNTLGTAKGHYLYIES 281
E C FE G IC + QD D+FDWT+ T T NTGP D + G+ +G Y+YIE+
Sbjct: 516 EFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIET 574
Query: 282 SEPQAFQDSAALLSPILNA--------TDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSR 333
S P+ + A LLSP+ + T+T C F F+YHM+G+ I L +Y R+ +
Sbjct: 575 SRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVYLRL----K 629
Query: 334 GQL-----LWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMD 386
GQ LW GN+G RW H+NI FQ++ E G G GDIAIDD+S +
Sbjct: 630 GQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
Score = 78.2 bits (191), Expect = 6e-14
Identities = 55/172 (31%), Positives = 86/172 (50%), Gaps = 20/172 (11%)
Query: 672 CDFEF-DLCSWKQEKDEDFDWNLKASSIP----AAGTEPAADHTLGNSSGHYIFINSLFP 726
C FE ++C + Q+ ++FDW ++++ T P AD + G+ G Y++I + P
Sbjct: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYMYIETSRP 577
Query: 727 QQPMRAARISSPVISKRSKN---------CKIIFHYHMYGNGIGALTLMQVSVTNQTKV- 776
+ AR+ SPV S KN C F YHMYG IG L + + + QT +
Sbjct: 578 RLEGEKARLLSPVFSIAPKNPYGPTNTAYC-FSFFYHMYGQHIGVLNVY-LRLKGQTTIE 635
Query: 777 --LLNLTVEQGNFWRREELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLTE 826
L + + +G W ++++ FQL FEG G G GDIA+DD+ + E
Sbjct: 636 NPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
Score = 69.3 bits (168), Expect = 3e-11
Identities = 47/177 (26%), Positives = 88/177 (49%), Gaps = 21/177 (11%)
Query: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHG-EENHRPSVDHTQNTTDGWYL 513
C FE ++C + Q D++ F W + + + N P+ D + + +G+Y+
Sbjct: 519 CGFEDGNICLFTQ-------DDTDNFDWTKQSTATRNTKYTPNTGPNADRS-GSKEGFYM 570
Query: 514 YADSSNGKF-GDTADILTPIISLT-----GPKCTLV---FWTHMNGATVGSLQVLIK--- 561
Y ++S + G+ A +L+P+ S+ GP T F+ HM G +G L V ++
Sbjct: 571 YIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKG 630
Query: 562 KDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQD 618
+ + + LW+ +G +G +W A V + + Q++F RG GD+A+DD+S +
Sbjct: 631 QTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAE 687
Score = 55.1 bits (131), Expect = 5e-07
Identities = 40/166 (24%), Positives = 71/166 (42%), Gaps = 11/166 (6%)
Query: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
C FE + F D+FDW + S + + + P + +G +M+I
Sbjct: 519 CGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPR 578
Query: 79 L-WQVAKLQSPTFS--------QTGPGCILSFWFYNYGLSVGAAELQLHMENSHD-STVI 128
L + A+L SP FS T SF+++ YG +G + L ++ +
Sbjct: 579 LEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPL 638
Query: 129 WRVLYNQGKQWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 174
W N+G++W EA + + ++ F L + + +G AIDD+
Sbjct: 639 WSSSGNKGQRWNEAHVNIYPITS-FQLIFEGIRGPGIEGDIAIDDV 683
Score = 47.0 bits (110), Expect = 1e-04
Identities = 47/179 (26%), Positives = 74/179 (41%), Gaps = 24/179 (13%)
Query: 1164 CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALI-----PDSDHTPGSGQHFLYVN 1218
C FE GN C TQD D+ DW S P++D + ++Y+
Sbjct: 519 CGFE--DGN---ICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIE 573
Query: 1219 SSGSK-EGSVARITT--------SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG 1269
+S + EG AR+ + + P + C +FY + + +G+L VY +
Sbjct: 574 TSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFS--FFYHMYGQHIGVLNVYLRLKGQ 631
Query: 1270 LNIL--VWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTP-EC 1325
I +WS GNK W V + + F++ FE + IA+DD+S EC
Sbjct: 632 TTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGEC 690
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 99.8 bits (247), Expect = 2e-20
Identities = 56/132 (42%), Positives = 64/132 (48%), Gaps = 9/132 (6%)
Query: 1330 PVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC 1389
P V+P PC + +C C+P CDG EDC DGSDE+DC P PP C EFPC
Sbjct: 277 PGSVRPLPCGPQEAAC-RNGHCIPRDYLCDGQEDCEDGSDELDC--GPPPP-CEPNEFPC 332
Query: 1390 STDECIPSLLLCDGVPDCHFNEDELICSNKS----CSNGALVCASSNSCIPAHQRCDGFA 1445
C L CDG DC DE C K C C S+N CIPA CD +
Sbjct: 333 GNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEES 392
Query: 1446 DCMDFQLDESSC 1457
DC D + DE C
Sbjct: 393 DCPD-RSDEFGC 403
Score = 72.0 bits (175), Expect = 4e-12
Identities = 52/172 (30%), Positives = 66/172 (38%), Gaps = 45/172 (26%)
Query: 1329 GPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCP-----LNPT----- 1378
G VP P C +F+C +CV L +CD DC D SDE++C ++PT
Sbjct: 190 GTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV 249
Query: 1379 ----------------PPL----------------CSNMEFPCSTDECIPSLLLCDGVPD 1406
PP+ C E C CIP LCDG D
Sbjct: 250 ETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQED 309
Query: 1407 CHFNEDELICS-NKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
C DEL C C C + + C RCDG DC D + DE++C
Sbjct: 310 CEDGSDELDCGPPPPCEPNEFPCGNGH-CALKLWRCDGDFDCED-RTDEANC 359
Score = 49.7 bits (117), Expect = 2e-05
Identities = 20/40 (50%), Positives = 27/40 (67%), Gaps = 1/40 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
PP C NEF C +GHC K+ +CD +DC D++DEA+C
Sbjct: 321 PPPPCEPNEFPC-GNGHCALKLWRCDGDFDCEDRTDEANC 359
Score = 45.1 bits (105), Expect = 5e-04
Identities = 26/66 (39%), Positives = 30/66 (45%), Gaps = 6/66 (9%)
Query: 1317 DDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC--P 1374
+D + C T P V C QF C+ T C+P S CD DC D SDE C P
Sbjct: 351 EDRTDEANCPTKRPEEV----CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPP 406
Query: 1375 LNPTPP 1380
TPP
Sbjct: 407 QVVTPP 412
Score = 43.1 bits (100), Expect = 0.002
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P CT+ EF C S C+ +CD + DC D SDE +C
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNC 234
Score = 43.1 bits (100), Expect = 0.002
Identities = 19/49 (38%), Positives = 24/49 (48%)
Query: 403 ETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
E + P P C +F C S CI CD + DCPD+SDE C+
Sbjct: 356 EANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCM 404
Score = 42.4 bits (98), Expect = 0.004
Identities = 20/49 (40%), Positives = 27/49 (55%), Gaps = 1/49 (2%)
Query: 402 PETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P+ +P ++ P C E CR+ GHCI + CD + DC D SDE C
Sbjct: 272 PQPLLPGSVRPLPCGPQEAACRN-GHCIPRDYLCDGQEDCEDGSDELDC 319
Score = 41.2 bits (95), Expect = 0.008
Identities = 17/32 (53%), Positives = 18/32 (56%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C E C N HCI +D LCD DC D SDE
Sbjct: 285 CGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Score = 40.4 bits (93), Expect = 0.013
Identities = 21/49 (42%), Positives = 22/49 (44%), Gaps = 1/49 (2%)
Query: 178 NCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP 226
NC P E C G F C T CI CD DC DR+DE C P
Sbjct: 358 NCPTKRPEEVC-GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMP 405
Score = 37.7 bits (86), Expect = 0.087
Identities = 38/142 (26%), Positives = 46/142 (32%), Gaps = 22/142 (15%)
Query: 1048 APNPVLSGSPTIPRQGSQQLGGWRGGSARHRARAFPEPECPRGRSALLKGPPQE-EPNRR 1106
AP P+L GS G Q+ G + +C G L GPP EPN
Sbjct: 271 APQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPN-- 328
Query: 1107 SALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC--AHYTSTTGSC 1164
+F C + C CD DC R+DEA+C G
Sbjct: 329 -----------------EFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPT 371
Query: 1165 NFETSSGNWTTACSLTQDSEDD 1186
F S N S D E D
Sbjct: 372 QFRCVSTNMCIPASFHCDEESD 393
Score = 36.6 bits (83), Expect = 0.19
Identities = 19/55 (34%), Positives = 23/55 (41%), Gaps = 7/55 (12%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTF-------ICRTSSGRC 672
P C +EF C N HC K CD DC D +DE +C + RC
Sbjct: 321 PPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Score = 35.4 bits (80), Expect = 0.43
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCANKH-CIAKDKLCDFVNDCADNSDE 660
GD +D + + P PE C +F C + + CI CD +DC D SDE
Sbjct: 346 GDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 35.0 bits (79), Expect = 0.56
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 5/64 (7%)
Query: 1111 SVGEISELCPEITDFLCRD-KKCIASHLLCDYKPDCSGRSDEAHCAHYT---STTGSCNF 1166
+V + C E +F C +C+A CD +PDC SDE +C S T S
Sbjct: 191 TVPQFPRACTE-AEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV 249
Query: 1167 ETSS 1170
ET+S
Sbjct: 250 ETTS 253
Score = 34.3 bits (77), Expect = 0.96
Identities = 20/67 (29%), Positives = 29/67 (43%), Gaps = 3/67 (4%)
Query: 1088 PRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSG 1147
PR + +++ PP + L G + L + CR+ CI LCD + DC
Sbjct: 256 PRPETTIMRQPPVTHAPQP---LLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCED 312
Query: 1148 RSDEAHC 1154
SDE C
Sbjct: 313 GSDELDC 319
Score = 34.3 bits (77), Expect = 0.96
Identities = 25/85 (29%), Positives = 35/85 (41%), Gaps = 13/85 (15%)
Query: 182 PLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC--------NFE 233
PLP E CR+ CI + LCD +DC D +DE++C P C N
Sbjct: 282 PLPCGPQEAA----CRNGH-CIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGH 336
Query: 234 TGICNWEQDAKDDFDWTRNQGPTPT 258
+ W D D + ++ PT
Sbjct: 337 CALKLWRCDGDFDCEDRTDEANCPT 361
Score = 33.9 bits (76), Expect = 1.3
Identities = 16/35 (45%), Positives = 20/35 (57%), Gaps = 1/35 (2%)
Query: 627 RKCTDHEFMCAN-KHCIAKDKLCDFVNDCADNSDE 660
R CT+ EF C + C+A + CD DC D SDE
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDE 231
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 99.0 bits (245), Expect = 3e-20
Identities = 65/189 (34%), Positives = 100/189 (52%), Gaps = 12/189 (6%)
Query: 219 TDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLY 278
+ E+N ++ CNFE G C W QD DD +W R QG T + TGP D+T G A G Y+
Sbjct: 336 SSELNNYEKINCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYIS 395
Query: 279 IESSEPQAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSD-SRGQLL 337
+ P Q+ LLS L+ T C F+YHM+G+ +++L+I I +D + + +
Sbjct: 396 TPTG-PGGRQERVGLLSLPLDPTLEPAC-LSFWYHMYGENVHKLSI--NISNDQNMEKTV 451
Query: 338 WQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLS----FMDCTLYPGN 393
+Q GN G+ W + ++ F++ A + DIA+DD+S + +LYP
Sbjct: 452 FQKEGNYGDNWNYGQVTLNETVKFKVAFNA-FKNKILSDIALDDISLTYGICNGSLYPE- 509
Query: 394 LPADLPTPP 402
P +PTPP
Sbjct: 510 -PTLVPTPP 517
Score = 71.6 bits (174), Expect = 5e-12
Identities = 48/154 (31%), Positives = 71/154 (46%), Gaps = 2/154 (1%)
Query: 672 CDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMR 731
C+FE C W Q+ ++D +W S + T P DHT GN+SG YI + + R
Sbjct: 347 CNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYISTPTGPGGRQER 406
Query: 732 AARISSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRRE 791
+S P+ C + F YHMYG + L++ + N K + G+ W
Sbjct: 407 VGLLSLPLDPTLEPAC-LSFWYHMYGENVHKLSINISNDQNMEKTVFQKEGNYGDNWNYG 465
Query: 792 ELSLFGDEDFQLKFEGRVGKGQRGDIALDDIVLT 825
+++L F++ F K DIALDDI LT
Sbjct: 466 QVTLNETVKFKVAFNAFKNK-ILSDIALDDISLT 498
Score = 60.8 bits (146), Expect = 1e-08
Identities = 51/176 (28%), Positives = 76/176 (43%), Gaps = 17/176 (9%)
Query: 455 CSFEKRSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLY 514
C+FE C W Q L D N + G+ S G P+ DHT G+Y+
Sbjct: 347 CNFED-GFCFWVQD-----LNDDNEWERIQGSTFSPFTG-----PNFDHTFGNASGFYIS 395
Query: 515 ADSSNGKFGDTADILT-PIISLTGPKCTLVFWTHMNGATVGSLQVLIKKD-NVTSKLWAQ 572
+ G + +L+ P+ P C L FW HM G V L + I D N+ ++ +
Sbjct: 396 TPTGPGGRQERVGLLSLPLDPTLEPAC-LSFWYHMYGENVHKLSINISNDQNMEKTVFQK 454
Query: 573 TGQQGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDIS--FQDCSPLLSPE 626
G G W +V L ++ F A + + D+A+DDIS + C+ L PE
Sbjct: 455 EGNYGDNWNYGQVTLNETVKFKVAFNAFKN-KILSDIALDDISLTYGICNGSLYPE 509
Score = 55.5 bits (132), Expect = 4e-07
Identities = 51/175 (29%), Positives = 70/175 (40%), Gaps = 17/175 (9%)
Query: 1163 SCNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIP----DSDHTPGSGQHFLYVN 1218
+CNFE W QD DD +W RI P + DHT G+ F Y++
Sbjct: 346 NCNFEDGFCFWV------QDLNDDNEW---ERIQGSTFSPFTGPNFDHTFGNASGF-YIS 395
Query: 1219 SSGSKEGSVARI-TTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSV 1277
+ G R+ S +L + FW++M ++ L + + + V+
Sbjct: 396 TPTGPGGRQERVGLLSLPLDPTLEPACLSFWYHMYG-ENVHKLSINISNDQNMEKTVFQK 454
Query: 1278 IGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVP 1332
GN W YG V L+ FKVAF A IALDDIS T G P
Sbjct: 455 EGNYGDNWNYGQVTLNETVKFKVAFNA-FKNKILSDIALDDISLTYGICNGSLYP 508
Score = 52.8 bits (125), Expect = 3e-06
Identities = 23/39 (58%), Positives = 25/39 (64%), Gaps = 1/39 (2%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC 1373
P PC+AD F C +CVPL CDGH C DGSDE DC
Sbjct: 640 PEPCKADHFQC-KNGECVPLVNLCDGHLHCEDGSDEADC 677
Score = 41.6 bits (96), Expect = 0.006
Identities = 38/157 (24%), Positives = 65/157 (41%), Gaps = 9/157 (5%)
Query: 19 CDFEANSCDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLNASQGHFMFILKKSSS 78
C+FE C W + ++ D+ +W R S S P DH+ + G ++
Sbjct: 347 CNFEDGFCFWVQDLNDDN-EWERIQGSTFSP---FTGPNFDHTFGNASGFYISTPTGPGG 402
Query: 79 LWQ-VAKLQSPTFSQTGPGCILSFWFYNYGLSVGAAELQLHMENSHDSTVIWRVLYNQGK 137
+ V L P P C LSFW++ YG +V + + + + + TV + N G
Sbjct: 403 RQERVGLLSLPLDPTLEPAC-LSFWYHMYGENVHKLSINISNDQNMEKTVFQKE-GNYGD 460
Query: 138 QWLEATIQLGRLSQPFHLSLDKVSLGIYDGVSAIDDI 174
W + L + F ++ + I + A+DDI
Sbjct: 461 NWNYGQVTLNE-TVKFKVAFNAFKNKILSDI-ALDDI 495
Score = 36.6 bits (83), Expect = 0.19
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 3/52 (5%)
Query: 1379 PPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELIC---SNKSCSNGALV 1427
P C F C EC+P + LCDG C DE C N + +N LV
Sbjct: 640 PEPCKADHFQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLV 691
Score = 36.6 bits (83), Expect = 0.19
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 8/68 (11%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHY----TSTTGSCNFETSSGNWTTACS-- 1178
F C++ +C+ LCD C SDEA C + T+ G F S W TAC+
Sbjct: 648 FQCKNGECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRIQS-IWHTACAEN 706
Query: 1179 -LTQDSED 1185
TQ S D
Sbjct: 707 WTTQISND 714
Score = 36.2 bits (82), Expect = 0.25
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 7/71 (9%)
Query: 1300 VAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCD 1359
V F DL+ + LD ++ T T G V ++ C C L C+ CD
Sbjct: 153 VTFHIDLNSVD----ILDKLTTTSHLATPGNVSIE---CLPGSSPCTDALTCIKADLFCD 205
Query: 1360 GHEDCIDGSDE 1370
G +C DGSDE
Sbjct: 206 GEVNCPDGSDE 216
Score = 36.2 bits (82), Expect = 0.25
Identities = 16/40 (40%), Positives = 21/40 (52%), Gaps = 1/40 (2%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
P C + F C++ G C+ + CD C D SDEA CV
Sbjct: 640 PEPCKADHFQCKN-GECVPLVNLCDGHLHCEDGSDEADCV 678
Score = 32.3 bits (72), Expect = 3.6
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 2/49 (4%)
Query: 885 SCTFEKGWCGWQNSQADNFDWVLGVGSHQS--LRPPKDHTLGNENAILL 931
+C FE G+C W D+ +W GS S P DHT GN + +
Sbjct: 346 NCNFEDGFCFWVQDLNDDNEWERIQGSTFSPFTGPNFDHTFGNASGFYI 394
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 98.6 bits (244), Expect = 4e-20
Identities = 52/125 (41%), Positives = 66/125 (52%), Gaps = 9/125 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
CE QF C +C+ L KCDG EDC+DGSDE +C C+ +F C+ +C+PS
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEKNC----VKKTCAESDFVCNNGQCVPS 87
Query: 1398 LLLCDGVPDCHFNEDEL--ICSNKSCSNGALVC-ASSNSCIPAHQRCDGFADCMDFQLDE 1454
CDG PDC DE C ++C + C A S CIP RCDG DC D DE
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDE 146
Query: 1455 SSCSD 1459
+C +
Sbjct: 147 ENCGN 151
Score = 93.6 bits (231), Expect = 1e-18
Identities = 55/137 (40%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 1323 PECVTGG---PVPVQPSPCEADQFSC-IYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPT 1378
P+C G P C + SC ++ QC+P+S +CDG DC G DE +C N T
Sbjct: 95 PDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG-NIT 153
Query: 1379 PPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAH 1438
CS EF CS+ CI +C+G DC DEL C+ +C C S++SCIP
Sbjct: 154 ---CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC-STSSCIPIS 209
Query: 1439 QRCDGFADCMDFQLDES 1455
CD ADC D Q DES
Sbjct: 210 WVCDDDADCSD-QSDES 225
Score = 87.8 bits (216), Expect = 7e-17
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 6/136 (4%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEM--DCPLNPT-PPLCSNMEFPCST 1391
P C A +F C T C+P+S CD DC D SDE C P C E C +
Sbjct: 190 PPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS 248
Query: 1392 DECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ 1451
ECI CDG PDC DE+ C +++C C SCI ++C+G DC+D
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC-EDGSCIHGSRQCNGIRDCVDGS 307
Query: 1452 LDESSCSDTWTLLGIG 1467
DE +C + LG G
Sbjct: 308 -DEVNCKNVNQCLGPG 322
Score = 77.8 bits (190), Expect = 8e-14
Identities = 87/355 (24%), Positives = 122/355 (34%), Gaps = 66/355 (18%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA---C 1177
E + F C + +CI CD DC SDE +C T +F ++G + C
Sbjct: 34 EPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV--KKTCAESDFVCNNGQCVPSRWKC 91
Query: 1178 SLTQDSEDDLDWA-------------IGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKE 1224
D ED D + I + IP S G SG E
Sbjct: 92 DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGEND-----CDSGEDE 146
Query: 1225 GSVARITTS-KSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRT 1283
+ IT S F S G C R + + N +
Sbjct: 147 ENCGNITCSPDEFTCSSGRCISR-----------------------------NFVCNGQD 177
Query: 1284 GWTYGSVPLSSNSPFKVAFEADLDGNEDI---FIALDDISFTPECVTG----GPVPVQPS 1336
+ GS L P A E + I ++ DD + + G PV +
Sbjct: 178 DCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT 237
Query: 1337 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C A + C + +C+ +CDG DC DGSDE++CP C +F C CI
Sbjct: 238 KCPASEIQC-GSGECIHKKWRCDGDPDCKDGSDEVNCPSR----TCRPDQFECEDGSCIH 292
Query: 1397 SLLLCDGVPDCHFNEDELICSN-KSCSNGALVCASSNSCIPAHQRCDGFADCMDF 1450
C+G+ DC DE+ C N C S CI + C+ DC D+
Sbjct: 293 GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW 347
Score = 68.6 bits (166), Expect = 5e-11
Identities = 95/364 (26%), Positives = 135/364 (37%), Gaps = 54/364 (14%)
Query: 1115 ISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNF-ETSSGNW 1173
+ + C E +DF+C + +C+ S CD PDC SDE+ + T C E S G
Sbjct: 68 VKKTCAE-SDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAH 123
Query: 1174 TTAC---SLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ----HFLYVN----SSGS 1222
+T C S D E+D D + T SG+ +F+ S GS
Sbjct: 124 STQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGS 183
Query: 1223 KEGSVARITT-SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNK 1281
E A T + F S C W D ++E+ G ++
Sbjct: 184 DELDCAPPTCGAHEFQCSTSSCIPISWV-CDDDADCSDQSDESLEQCGRQPVI------- 235
Query: 1282 RTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS-PCEA 1340
T + S + D D P+C G PS C
Sbjct: 236 HTKCPASEIQCGSGECIHKKWRCDGD---------------PDCKDGSDEVNCPSRTCRP 280
Query: 1341 DQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLL 1400
DQF C C+ S +C+G DC+DGSDE++C N L +F C + ECI +
Sbjct: 281 DQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPG-KFKCRSGECIDISKV 337
Query: 1401 CDGVPDCHFNEDELI--CSNKSC--SNGALVCASSNSCIPAHQRCDGFADCMDFQL-DES 1455
C+ DC DE + C C +NG C+ + CD A F+L D
Sbjct: 338 CNQEQDCRDWSDEPLKECHINECLVNNGG--CSHICKDLVIGYECDCAA---GFELIDRK 392
Query: 1456 SCSD 1459
+C D
Sbjct: 393 TCGD 396
Score = 44.7 bits (104), Expect = 7e-04
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 401 PPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKR 460
P E+ T C ++F C ++G CI + KCD DC D SDE +CV + C+ E
Sbjct: 19 PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA-ESD 76
Query: 461 SLCKWYQPIP 470
+C Q +P
Sbjct: 77 FVCNNGQCVP 86
Score = 43.5 bits (101), Expect = 0.002
Identities = 33/110 (30%), Positives = 50/110 (45%), Gaps = 12/110 (10%)
Query: 1113 GEISELCPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFET 1168
GE E C IT +F C +CI+ + +C+ + DCS SDE CA T G+ F+
Sbjct: 143 GEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--PPTCGAHEFQC 200
Query: 1169 SSGNW---TTACSLTQDSEDDLDWAI---GSRIPAKALIPDSDHTPGSGQ 1212
S+ + + C D D D ++ G + P S+ GSG+
Sbjct: 201 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGE 250
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 13/82 (15%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP------ELQCNFE-----TGICNWE 240
D F C R CI + +C+ DDC D +DE++CAP E QC+ + +C+ +
Sbjct: 157 DEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDD 215
Query: 241 QDAKDDFDWTRNQ-GPTPTLNT 261
D D D + Q G P ++T
Sbjct: 216 ADCSDQSDESLEQCGRQPVIHT 237
Score = 39.7 bits (91), Expect = 0.023
Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 3/49 (6%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA--SCVMEVCSFEKRS 461
C +++F+C ++G C+ KCD DC D SDE+ C M C + S
Sbjct: 72 CAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEIS 119
Score = 39.7 bits (91), Expect = 0.023
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 618 DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
DC+P C HEF C+ CI +CD DC+D SDE+ C
Sbjct: 187 DCAP-----PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC 229
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 14/86 (16%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT------------FICRTSSGRC 672
P R C +F C + CI + C+ + DC D SDE F CR SG C
Sbjct: 274 PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCR--SGEC 331
Query: 673 DFEFDLCSWKQEKDEDFDWNLKASSI 698
+C+ +Q+ + D LK I
Sbjct: 332 IDISKVCNQEQDCRDWSDEPLKECHI 357
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 15/75 (20%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC----NFE------ 233
P+ +C D F C +CI R C+ + DC D +DEVNC QC F+
Sbjct: 274 PSRTCRP-DQFECEDG-SCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC 331
Query: 234 ---TGICNWEQDAKD 245
+ +CN EQD +D
Sbjct: 332 IDISKVCNQEQDCRD 346
Score = 38.9 bits (89), Expect = 0.039
Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474
C+ +EF C S G CI + C+ + DC D SDE C C + C IP+ +
Sbjct: 154 CSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQ-CSTSSCIPISWV 211
Query: 475 QDSN 478
D +
Sbjct: 212 CDDD 215
Score = 38.5 bits (88), Expect = 0.051
Identities = 21/73 (28%), Positives = 32/73 (43%), Gaps = 8/73 (10%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGR-----CDFEFDLC- 679
++ C + +F+C N C+ CD DC D SDE+ C + R C C
Sbjct: 69 KKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCI 128
Query: 680 --SWKQEKDEDFD 690
SW+ + + D D
Sbjct: 129 PVSWRCDGENDCD 141
Score = 38.5 bits (88), Expect = 0.051
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C +E C S G CI K +CD DC D SDE +C C
Sbjct: 239 CPASEIQCGS-GECIHKKWRCDGDPDCKDGSDEVNCPSRTC 278
Score = 38.5 bits (88), Expect = 0.051
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 1/52 (1%)
Query: 399 PTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P + S V P C ++F C DG CI ++C+ DC D SDE +C
Sbjct: 262 PDCKDGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNC 312
Score = 37.7 bits (86), Expect = 0.087
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 10/51 (19%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDET----------TFICRTSS 669
C+ EF C++ CI+++ +C+ +DC+D SDE F C TSS
Sbjct: 154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS 204
Score = 37.4 bits (85), Expect = 0.11
Identities = 24/70 (34%), Positives = 28/70 (40%), Gaps = 5/70 (7%)
Query: 603 ISYIGDVAVD-----DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADN 657
IS++ D D D S + C KC E C + CI K CD DC D
Sbjct: 208 ISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDG 267
Query: 658 SDETTFICRT 667
SDE RT
Sbjct: 268 SDEVNCPSRT 277
Score = 37.0 bits (84), Expect = 0.15
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 12/69 (17%)
Query: 628 KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS------- 680
KC +F C N CI CD DC D SDE + +T + DF +C+
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA-ESDF---VCNNGQCVPS 87
Query: 681 -WKQEKDED 688
WK + D D
Sbjct: 88 RWKCDGDPD 96
Score = 34.3 bits (77), Expect = 0.96
Identities = 30/96 (31%), Positives = 37/96 (38%), Gaps = 16/96 (16%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCA--NKHCIAKDKLCDFVNDCADNSDETT-- 662
GD +D S D SP R C HE C + CI CD NDC DE
Sbjct: 93 GDPDCEDGS--DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 663 --------FICRTSSGRCDFEFDLCSWKQEKDEDFD 690
F C SSGRC +C+ + + + D
Sbjct: 151 NITCSPDEFTC--SSGRCISRNFVCNGQDDCSDGSD 184
Score = 32.3 bits (72), Expect = 3.6
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 10/70 (14%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICN--------WEQDAKD 245
F C + R CI L CD +DC D +DE NC + C +CN W+ D
Sbjct: 38 FQCTNGR-CITLLWKCDGDEDCVDGSDEKNCVKK-TCAESDFVCNNGQCVPSRWKCDGDP 95
Query: 246 DFDWTRNQGP 255
D + ++ P
Sbjct: 96 DCEDGSDESP 105
Score = 32.0 bits (71), Expect = 4.8
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 163 GIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV 222
GI D V D++ +N C G F CR + CI+ ++C+ DC D +DE
Sbjct: 299 GIRDCVDGSDEVNCKN------VNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDE- 350
Query: 223 NCAPELQCNFETGICN 238
P +C+ + N
Sbjct: 351 ---PLKECHINECLVN 363
Score = 31.2 bits (69), Expect = 8.1
Identities = 23/75 (30%), Positives = 29/75 (38%), Gaps = 11/75 (14%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI-----CNWEQDAKDDFDWT 250
CI K CD DC D +DEVNC + +C + I CN +D D D
Sbjct: 251 CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEV 310
Query: 251 RNQGPTPTLNTGPMK 265
+ L G K
Sbjct: 311 NCKNVNQCLGPGKFK 325
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 98.6 bits (244), Expect = 4e-20
Identities = 52/125 (41%), Positives = 66/125 (52%), Gaps = 9/125 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
CE QF C +C+ L KCDG EDC+DGSDE +C C+ +F C+ +C+PS
Sbjct: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEKNC----VKKTCAESDFVCNNGQCVPS 87
Query: 1398 LLLCDGVPDCHFNEDEL--ICSNKSCSNGALVC-ASSNSCIPAHQRCDGFADCMDFQLDE 1454
CDG PDC DE C ++C + C A S CIP RCDG DC D DE
Sbjct: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDE 146
Query: 1455 SSCSD 1459
+C +
Sbjct: 147 ENCGN 151
Score = 93.6 bits (231), Expect = 1e-18
Identities = 55/137 (40%), Positives = 70/137 (51%), Gaps = 10/137 (7%)
Query: 1323 PECVTGG---PVPVQPSPCEADQFSC-IYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPT 1378
P+C G P C + SC ++ QC+P+S +CDG DC G DE +C N T
Sbjct: 95 PDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG-NIT 153
Query: 1379 PPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAH 1438
CS EF CS+ CI +C+G DC DEL C+ +C C S++SCIP
Sbjct: 154 ---CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC-STSSCIPIS 209
Query: 1439 QRCDGFADCMDFQLDES 1455
CD ADC D Q DES
Sbjct: 210 WVCDDDADCSD-QSDES 225
Score = 87.8 bits (216), Expect = 7e-17
Identities = 50/136 (36%), Positives = 64/136 (47%), Gaps = 6/136 (4%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEM--DCPLNPT-PPLCSNMEFPCST 1391
P C A +F C T C+P+S CD DC D SDE C P C E C +
Sbjct: 190 PPTCGAHEFQCS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS 248
Query: 1392 DECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ 1451
ECI CDG PDC DE+ C +++C C SCI ++C+G DC+D
Sbjct: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC-EDGSCIHGSRQCNGIRDCVDGS 307
Query: 1452 LDESSCSDTWTLLGIG 1467
DE +C + LG G
Sbjct: 308 -DEVNCKNVNQCLGPG 322
Score = 77.8 bits (190), Expect = 8e-14
Identities = 87/355 (24%), Positives = 122/355 (34%), Gaps = 66/355 (18%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA---C 1177
E + F C + +CI CD DC SDE +C T +F ++G + C
Sbjct: 34 EPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV--KKTCAESDFVCNNGQCVPSRWKC 91
Query: 1178 SLTQDSEDDLDWA-------------IGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKE 1224
D ED D + I + IP S G SG E
Sbjct: 92 DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGEND-----CDSGEDE 146
Query: 1225 GSVARITTS-KSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRT 1283
+ IT S F S G C R + + N +
Sbjct: 147 ENCGNITCSPDEFTCSSGRCISR-----------------------------NFVCNGQD 177
Query: 1284 GWTYGSVPLSSNSPFKVAFEADLDGNEDI---FIALDDISFTPECVTG----GPVPVQPS 1336
+ GS L P A E + I ++ DD + + G PV +
Sbjct: 178 DCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT 237
Query: 1337 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C A + C + +C+ +CDG DC DGSDE++CP C +F C CI
Sbjct: 238 KCPASEIQC-GSGECIHKKWRCDGDPDCKDGSDEVNCPSR----TCRPDQFECEDGSCIH 292
Query: 1397 SLLLCDGVPDCHFNEDELICSN-KSCSNGALVCASSNSCIPAHQRCDGFADCMDF 1450
C+G+ DC DE+ C N C S CI + C+ DC D+
Sbjct: 293 GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW 347
Score = 68.6 bits (166), Expect = 5e-11
Identities = 95/364 (26%), Positives = 135/364 (37%), Gaps = 54/364 (14%)
Query: 1115 ISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNF-ETSSGNW 1173
+ + C E +DF+C + +C+ S CD PDC SDE+ + T C E S G
Sbjct: 68 VKKTCAE-SDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAH 123
Query: 1174 TTAC---SLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQ----HFLYVN----SSGS 1222
+T C S D E+D D + T SG+ +F+ S GS
Sbjct: 124 STQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGS 183
Query: 1223 KEGSVARITT-SKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNK 1281
E A T + F S C W D ++E+ G ++
Sbjct: 184 DELDCAPPTCGAHEFQCSTSSCIPISWV-CDDDADCSDQSDESLEQCGRQPVI------- 235
Query: 1282 RTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPS-PCEA 1340
T + S + D D P+C G PS C
Sbjct: 236 HTKCPASEIQCGSGECIHKKWRCDGD---------------PDCKDGSDEVNCPSRTCRP 280
Query: 1341 DQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLL 1400
DQF C C+ S +C+G DC+DGSDE++C N L +F C + ECI +
Sbjct: 281 DQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCK-NVNQCLGPG-KFKCRSGECIDISKV 337
Query: 1401 CDGVPDCHFNEDELI--CSNKSC--SNGALVCASSNSCIPAHQRCDGFADCMDFQL-DES 1455
C+ DC DE + C C +NG C+ + CD A F+L D
Sbjct: 338 CNQEQDCRDWSDEPLKECHINECLVNNGG--CSHICKDLVIGYECDCAA---GFELIDRK 392
Query: 1456 SCSD 1459
+C D
Sbjct: 393 TCGD 396
Score = 44.7 bits (104), Expect = 7e-04
Identities = 25/70 (35%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 401 PPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKR 460
P E+ T C ++F C ++G CI + KCD DC D SDE +CV + C+ E
Sbjct: 19 PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA-ESD 76
Query: 461 SLCKWYQPIP 470
+C Q +P
Sbjct: 77 FVCNNGQCVP 86
Score = 43.5 bits (101), Expect = 0.002
Identities = 33/110 (30%), Positives = 50/110 (45%), Gaps = 12/110 (10%)
Query: 1113 GEISELCPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFET 1168
GE E C IT +F C +CI+ + +C+ + DCS SDE CA T G+ F+
Sbjct: 143 GEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--PPTCGAHEFQC 200
Query: 1169 SSGNW---TTACSLTQDSEDDLDWAI---GSRIPAKALIPDSDHTPGSGQ 1212
S+ + + C D D D ++ G + P S+ GSG+
Sbjct: 201 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGE 250
Score = 42.4 bits (98), Expect = 0.004
Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 13/82 (15%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP------ELQCNFE-----TGICNWE 240
D F C R CI + +C+ DDC D +DE++CAP E QC+ + +C+ +
Sbjct: 157 DEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDD 215
Query: 241 QDAKDDFDWTRNQ-GPTPTLNT 261
D D D + Q G P ++T
Sbjct: 216 ADCSDQSDESLEQCGRQPVIHT 237
Score = 39.7 bits (91), Expect = 0.023
Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 3/49 (6%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA--SCVMEVCSFEKRS 461
C +++F+C ++G C+ KCD DC D SDE+ C M C + S
Sbjct: 72 CAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEIS 119
Score = 39.7 bits (91), Expect = 0.023
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 5/48 (10%)
Query: 618 DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
DC+P C HEF C+ CI +CD DC+D SDE+ C
Sbjct: 187 DCAP-----PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC 229
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 14/86 (16%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT------------FICRTSSGRC 672
P R C +F C + CI + C+ + DC D SDE F CR SG C
Sbjct: 274 PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCR--SGEC 331
Query: 673 DFEFDLCSWKQEKDEDFDWNLKASSI 698
+C+ +Q+ + D LK I
Sbjct: 332 IDISKVCNQEQDCRDWSDEPLKECHI 357
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/75 (34%), Positives = 36/75 (48%), Gaps = 15/75 (20%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC----NFE------ 233
P+ +C D F C +CI R C+ + DC D +DEVNC QC F+
Sbjct: 274 PSRTCRP-DQFECEDG-SCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC 331
Query: 234 ---TGICNWEQDAKD 245
+ +CN EQD +D
Sbjct: 332 IDISKVCNQEQDCRD 346
Score = 38.9 bits (89), Expect = 0.039
Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 2/64 (3%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474
C+ +EF C S G CI + C+ + DC D SDE C C + C IP+ +
Sbjct: 154 CSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQ-CSTSSCIPISWV 211
Query: 475 QDSN 478
D +
Sbjct: 212 CDDD 215
Score = 38.5 bits (88), Expect = 0.051
Identities = 21/73 (28%), Positives = 32/73 (43%), Gaps = 8/73 (10%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGR-----CDFEFDLC- 679
++ C + +F+C N C+ CD DC D SDE+ C + R C C
Sbjct: 69 KKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCI 128
Query: 680 --SWKQEKDEDFD 690
SW+ + + D D
Sbjct: 129 PVSWRCDGENDCD 141
Score = 38.5 bits (88), Expect = 0.051
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C +E C S G CI K +CD DC D SDE +C C
Sbjct: 239 CPASEIQCGS-GECIHKKWRCDGDPDCKDGSDEVNCPSRTC 278
Score = 38.5 bits (88), Expect = 0.051
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 1/52 (1%)
Query: 399 PTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P + S V P C ++F C DG CI ++C+ DC D SDE +C
Sbjct: 262 PDCKDGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNC 312
Score = 37.7 bits (86), Expect = 0.087
Identities = 18/51 (35%), Positives = 28/51 (54%), Gaps = 10/51 (19%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDET----------TFICRTSS 669
C+ EF C++ CI+++ +C+ +DC+D SDE F C TSS
Sbjct: 154 CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS 204
Score = 37.4 bits (85), Expect = 0.11
Identities = 24/70 (34%), Positives = 28/70 (40%), Gaps = 5/70 (7%)
Query: 603 ISYIGDVAVD-----DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADN 657
IS++ D D D S + C KC E C + CI K CD DC D
Sbjct: 208 ISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDG 267
Query: 658 SDETTFICRT 667
SDE RT
Sbjct: 268 SDEVNCPSRT 277
Score = 37.0 bits (84), Expect = 0.15
Identities = 23/69 (33%), Positives = 30/69 (43%), Gaps = 12/69 (17%)
Query: 628 KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS------- 680
KC +F C N CI CD DC D SDE + +T + DF +C+
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA-ESDF---VCNNGQCVPS 87
Query: 681 -WKQEKDED 688
WK + D D
Sbjct: 88 RWKCDGDPD 96
Score = 34.3 bits (77), Expect = 0.96
Identities = 30/96 (31%), Positives = 37/96 (38%), Gaps = 16/96 (16%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCA--NKHCIAKDKLCDFVNDCADNSDETT-- 662
GD +D S D SP R C HE C + CI CD NDC DE
Sbjct: 93 GDPDCEDGS--DESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 663 --------FICRTSSGRCDFEFDLCSWKQEKDEDFD 690
F C SSGRC +C+ + + + D
Sbjct: 151 NITCSPDEFTC--SSGRCISRNFVCNGQDDCSDGSD 184
Score = 32.3 bits (72), Expect = 3.6
Identities = 22/70 (31%), Positives = 31/70 (44%), Gaps = 10/70 (14%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICN--------WEQDAKD 245
F C + R CI L CD +DC D +DE NC + C +CN W+ D
Sbjct: 38 FQCTNGR-CITLLWKCDGDEDCVDGSDEKNCVKK-TCAESDFVCNNGQCVPSRWKCDGDP 95
Query: 246 DFDWTRNQGP 255
D + ++ P
Sbjct: 96 DCEDGSDESP 105
Score = 32.0 bits (71), Expect = 4.8
Identities = 22/76 (28%), Positives = 34/76 (44%), Gaps = 11/76 (14%)
Query: 163 GIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV 222
GI D V D++ +N C G F CR + CI+ ++C+ DC D +DE
Sbjct: 299 GIRDCVDGSDEVNCKN------VNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDE- 350
Query: 223 NCAPELQCNFETGICN 238
P +C+ + N
Sbjct: 351 ---PLKECHINECLVN 363
Score = 31.2 bits (69), Expect = 8.1
Identities = 23/75 (30%), Positives = 29/75 (38%), Gaps = 11/75 (14%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI-----CNWEQDAKDDFDWT 250
CI K CD DC D +DEVNC + +C + I CN +D D D
Sbjct: 251 CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEV 310
Query: 251 RNQGPTPTLNTGPMK 265
+ L G K
Sbjct: 311 NCKNVNQCLGPGKFK 325
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 97.8 bits (242), Expect = 7e-20
Identities = 51/127 (40%), Positives = 66/127 (51%), Gaps = 6/127 (4%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC-STDECIP 1396
C + QF C +C+P++ +C+G +DC D DE DCP N CS F C +T CI
Sbjct: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS----CSPDYFQCKTTKHCIS 3451
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
L +CD PDC DE C K+C C +N+CIP H RCD DC D +E+
Sbjct: 3452 KLWVCDEDPDCADASDEANCDKKTCGPHEFQC-KNNNCIPDHWRCDSQNDCSDNSDEENC 3510
Query: 1457 CSDTWTL 1463
T TL
Sbjct: 3511 KPQTCTL 3517
Score = 94.0 bits (232), Expect = 1e-18
Identities = 52/125 (41%), Positives = 62/125 (49%), Gaps = 7/125 (5%)
Query: 1336 SPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD-CPLNPTPPLCSNMEFPCSTDEC 1394
S C A QF C T +C+P KCD +DC DGSDE D CP C F C T C
Sbjct: 3315 SNCTASQFRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCP----EFRCQPGRFQCGTGLC 3369
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
+CDG DC N DEL C C +G C + CIP + RC+G DC D + DE
Sbjct: 3370 ALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGD-EEDE 3428
Query: 1455 SSCSD 1459
C +
Sbjct: 3429 RDCPE 3433
Score = 89.4 bits (220), Expect = 3e-17
Identities = 50/126 (39%), Positives = 65/126 (51%), Gaps = 10/126 (7%)
Query: 1334 QPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDE 1393
+P C F C CV CDG DC DGSDE +C + CS +F CS +
Sbjct: 3511 KPQTCTLKDFLCANG-DCVSSRFWCDGDFDCADGSDERNCETS-----CSKDQFRCSNGQ 3564
Query: 1394 CIPSLLLCDGVPDCHFNEDELIC--SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ 1451
CIP+ CDG DC + EDE C ++ +CS+ +CA S+ CI A +C+G DC D
Sbjct: 3565 CIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICA-SDGCISASLKCNGEYDCADGS 3623
Query: 1452 LDESSC 1457
DE C
Sbjct: 3624 -DEMDC 3628
Score = 86.3 bits (212), Expect = 2e-16
Identities = 49/133 (36%), Positives = 64/133 (48%), Gaps = 6/133 (4%)
Query: 1327 TGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNME 1386
T P P C+A +F C C+ KCDG +DC+DGSDE +N C + +
Sbjct: 834 TFNPGEALPHICKAGEFRC-KNRHCIQARWKCDGDDDCLDGSDEDS--VNCFNHSCPDDQ 890
Query: 1387 FPCSTDECIPSLLLCDGVPDCHFNEDE--LICSNKSCSNGALVCASSNSCIPAHQRCDGF 1444
F C + CIP LCDG DC NEDE C+ ++C C + CIP CD
Sbjct: 891 FKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGR-CIPRAWLCDRE 949
Query: 1445 ADCMDFQLDESSC 1457
DC D + +SC
Sbjct: 950 DDCGDQTDEMASC 962
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/142 (33%), Positives = 64/142 (45%), Gaps = 6/142 (4%)
Query: 1324 ECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCS 1383
+C G + C+ DQF C C+P+ CDG DC+DGSDE +C +C
Sbjct: 3618 DCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGN--ICR 3675
Query: 1384 NMEFPCSTDECIPSLLLCDGVPDCHFNEDEL--ICSNKSC-SNGALVCASSNSCIPAHQR 1440
EF C+ C +CDG DC N DE +C C S C ++ C+ + Q
Sbjct: 3676 ADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNRICLQSEQM 3735
Query: 1441 CDGFADCMDFQLDESSCSDTWT 1462
C+G +C D DE C T
Sbjct: 3736 CNGIDECGD-NSDEDHCGGKLT 3756
Score = 81.6 bits (200), Expect = 5e-15
Identities = 93/344 (27%), Positives = 127/344 (36%), Gaps = 86/344 (25%)
Query: 1119 CPEITD----FLCRDKK-CIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNW 1173
CPE + F C+ K CI+ +CD PDC+ SDEA+C T G F+ + N
Sbjct: 3431 CPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCD--KKTCGPHEFQCKNNN- 3487
Query: 1174 TTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARITTS 1233
IP DH Q+ NS +E + T
Sbjct: 3488 --------------------------CIP--DHWRCDSQNDCSDNS--DEENCKPQTCTL 3517
Query: 1234 KSFPASLGMC-TVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPL 1292
K F + G C + RFW + + S N T +
Sbjct: 3518 KDFLCANGDCVSSRFWC-----------------DGDFDCADGSDERNCETSCSKDQFRC 3560
Query: 1293 SSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCV 1352
S+ ++ DG+ED D+ S P T C + ++ C + C+
Sbjct: 3561 SNGQCIPAKWKC--DGHEDCKYGEDEKSCEPASPT----------CSSREYICA-SDGCI 3607
Query: 1353 PLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCHFNE 1411
S KC+G DC DGSDEMDC C +F C CIP LCDG+ DC
Sbjct: 3608 SASLKCNGEYDCADGSDEMDCVTE-----CKEDQFRCKNKAHCIPIRWLCDGIHDCVDGS 3662
Query: 1412 DELICSNKSCSNGALVCAS-----SNSCIPAH-QRCDGFADCMD 1449
DE ++C G +C + +NS H CDG DC D
Sbjct: 3663 DE-----ENCERGGNICRADEFLCNNSLCKLHFWVCDGEDDCGD 3701
Score = 81.3 bits (199), Expect = 7e-15
Identities = 43/120 (35%), Positives = 55/120 (45%), Gaps = 6/120 (5%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C D F C T C+ CD DC D SDE +C C EF C + CIP
Sbjct: 3436 CSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT----CGPHEFQCKNNNCIPD 3491
Query: 1398 LLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
CD DC N DE C ++C+ +CA+ + C+ + CDG DC D DE +C
Sbjct: 3492 HWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGD-CVSSRFWCDGDFDCADGS-DERNC 3549
Score = 80.5 bits (197), Expect = 1e-14
Identities = 43/124 (34%), Positives = 60/124 (48%), Gaps = 14/124 (11%)
Query: 1343 FSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCD 1402
F Y +C+P CDG DC D SDE+DC ++ C+ +EF C+ CIP C+
Sbjct: 2556 FKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVST----CATVEFRCADGTCIPRSARCN 2611
Query: 1403 GVPDCHFNEDELICSNKSCSN---------GALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
DC DE C+N C++ G + C S++ C+ CDG DC D+ D
Sbjct: 2612 QNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYS-D 2670
Query: 1454 ESSC 1457
E C
Sbjct: 2671 ELKC 2674
Score = 80.5 bits (197), Expect = 1e-14
Identities = 50/147 (34%), Positives = 59/147 (40%), Gaps = 17/147 (11%)
Query: 1307 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1366
DG +D LD+ +T C AD FSC + CVP CDG DC D
Sbjct: 2740 DGEDDCGDGLDESDSICGAIT----------CAADMFSCQGSRACVPRHWLCDGERDCPD 2789
Query: 1367 GSDEMD---CPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDEL-ICSNKSCS 1422
GSDE+ C N T C F C CIP +CD DC DE C + C
Sbjct: 2790 GSDELSTAGCAPNNT---CDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCG 2846
Query: 1423 NGALVCASSNSCIPAHQRCDGFADCMD 1449
CA + +CDG DC D
Sbjct: 2847 TEEFSCADGRCLLNTQWQCDGDFDCPD 2873
Score = 80.1 bits (196), Expect = 2e-14
Identities = 46/118 (38%), Positives = 59/118 (50%), Gaps = 5/118 (4%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSN-MEFPC-STD 1392
P+ C ++F C CVP +CDG +DC DGSDE C N T LC + +F C ST
Sbjct: 1050 PAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC--NGTIRLCDHKTKFSCWSTG 1107
Query: 1393 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNS-CIPAHQRCDGFADCMD 1449
CI +CDG DC DE C + C CA+ S C+ + C+G DC D
Sbjct: 1108 RCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPD 1165
Score = 77.4 bits (189), Expect = 1e-13
Identities = 46/111 (41%), Positives = 54/111 (48%), Gaps = 4/111 (3%)
Query: 1345 CIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGV 1404
C T CV + CDG DC D SDE+ CP+ C F C + CI + +CDG
Sbjct: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPVQ-NKHKCEENYFSCPSGRCILNTWICDGQ 2704
Query: 1405 PDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1455
DC DE C + SCS C S+ CI H CDG DC D LDES
Sbjct: 2705 KDCEDGRDEFHC-DSSCSWNQFAC-SAQKCISKHWICDGEDDCGD-GLDES 2752
Score = 75.1 bits (183), Expect = 5e-13
Identities = 45/127 (35%), Positives = 58/127 (45%), Gaps = 15/127 (11%)
Query: 1342 QFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLC 1401
QF C + +C+ CD +DC DGSDE+ C + C + +F CS+ CIP C
Sbjct: 972 QFVC-KSGRCISSKWHCDSDDDCGDGSDEVGCVHS-----CFDNQFRCSSGRCIPGHWAC 1025
Query: 1402 DGVPDCHFNEDEL--------ICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
DG DC DE I S C+ C +C+P RCDG DC D D
Sbjct: 1026 DGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGS-D 1084
Query: 1454 ESSCSDT 1460
E C+ T
Sbjct: 1085 EKGCNGT 1091
Score = 70.9 bits (172), Expect = 9e-12
Identities = 88/365 (24%), Positives = 131/365 (35%), Gaps = 60/365 (16%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEA--HCAHYTSTTGS------------- 1163
C ++F C + +CI L CD P C +SDE +C + + G
Sbjct: 2510 CNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGK 2569
Query: 1164 -CNFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGS 1222
C+ E G D+ D+LD + + + D P S + ++ + +
Sbjct: 2570 LCDGENDCG----------DNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADA 2619
Query: 1223 KEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESG-----LNILVWSV 1277
+ T F LG+ T F + S+ +L + + S + L V
Sbjct: 2620 SDEKNCNNTDCTHF-YKLGVKTTGF--IRCNSTSLCVLPTWICDGSNDCGDYSDELKCPV 2676
Query: 1278 IGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSP 1337
+ Y S P S + DG +D D+ C S
Sbjct: 2677 QNKHKCEENYFSCP----SGRCILNTWICDGQKDCEDGRDEF----HC---------DSS 2719
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC-STDECIP 1396
C +QF+C +C+ CDG +DC DG DE D C+ F C + C+P
Sbjct: 2720 CSWNQFACS-AQKCISKHWICDGEDDCGDGLDESDSICGAI--TCAADMFSCQGSRACVP 2776
Query: 1397 SLLLCDGVPDCHFNEDEL----ICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
LCDG DC DEL N +C A +C + CIP CD DC D
Sbjct: 2777 RHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMC-HNKVCIPKQFVCDHDDDCGDGSD 2835
Query: 1453 DESSC 1457
+ C
Sbjct: 2836 ESPQC 2840
Score = 70.1 bits (170), Expect = 2e-11
Identities = 47/126 (37%), Positives = 57/126 (45%), Gaps = 6/126 (4%)
Query: 1336 SPCEA-DQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDEC 1394
S C A +F C +C+ CDG C D SDE L C PC C
Sbjct: 2508 SSCNAYSEFEC-GNGECIDYQLTCDGIPHCKDKSDEK--LLYCENRSCRRGFKPCYNRRC 2564
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
IP LCDG DC N DEL C +C+ CA +CIP RC+ DC D DE
Sbjct: 2565 IPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCA-DGTCIPRSARCNQNIDCADAS-DE 2622
Query: 1455 SSCSDT 1460
+C++T
Sbjct: 2623 KNCNNT 2628
Score = 64.3 bits (155), Expect = 9e-10
Identities = 70/274 (25%), Positives = 98/274 (35%), Gaps = 78/274 (28%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIP 470
P ++C+ + F C++ HCI K+ CD DC D SDEA+C + C CK IP
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCG-PHEFQCKNNNCIP 3490
Query: 471 VHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILT 530
H DS N S + EEN +P
Sbjct: 3491 DHWRCDSQ-------NDCSDNSDEENCKPQT----------------------------- 3514
Query: 531 PIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTG---QQGAQWKRAEVFL 587
CTL + NG D V+S+ W G+ + E
Sbjct: 3515 ---------CTLKDFLCANG------------DCVSSRFWCDGDFDCADGSDERNCET-- 3551
Query: 588 GIRSHTQIVFRAKRGISYIGDVAVD---DISF----QDCSPLLSPERKCTDHEFMCANKH 640
S ++ FR G D D + + C P SP C+ E++CA+
Sbjct: 3552 ---SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP-ASP--TCSSREYICASDG 3605
Query: 641 CIAKDKLCDFVNDCADNSDETTFI--CRTSSGRC 672
CI+ C+ DCAD SDE + C+ RC
Sbjct: 3606 CISASLKCNGEYDCADGSDEMDCVTECKEDQFRC 3639
Score = 60.1 bits (144), Expect = 2e-08
Identities = 43/129 (33%), Positives = 54/129 (41%), Gaps = 12/129 (9%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNP----TPPLCSNMEFPCSTDE 1393
C ++FSC + +CDG DC D SDE PLNP C++ F C
Sbjct: 2845 CGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDE--APLNPKCKSAEQSCNSSFFMCKNGR 2902
Query: 1394 CIPSLLLCDGVPDCHFNEDELICSNKSC-SNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
CIPS LCD DC DE C C S C+ +P +C + FQL
Sbjct: 2903 CIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPVSYKCKCWP---GFQL 2959
Query: 1453 --DESSCSD 1459
D +C D
Sbjct: 2960 KDDGKTCVD 2968
Score = 59.3 bits (142), Expect = 3e-08
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 9/119 (7%)
Query: 1342 QFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDE--CIPSLL 1399
+FSC T +C+ + CDG DC D SDE DC LC + PC+ D C+
Sbjct: 1100 KFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSF----LCGPPKHPCANDTSVCLQPEK 1155
Query: 1400 LCDGVPDCHFNEDE-LICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
LC+G DC DE +C S +NG C++ S +P + + D +C
Sbjct: 1156 LCNGKKDCPDGSDEGYLCDECSLNNGG--CSNHCSVVPGRGIVCSCPEGLQLNKDNKTC 1212
Score = 58.9 bits (141), Expect = 4e-08
Identities = 39/140 (27%), Positives = 61/140 (43%), Gaps = 21/140 (15%)
Query: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
GG + + PC+ D+F+C +C+P+ +CD +DC DGSDE C + PT C +
Sbjct: 3752 GGKLTYKARPCKKDEFACS-NKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVN 3810
Query: 1388 PCSTD---ECIPSLLLCDGVPDCHFNEDELICSN-------KSCSNGALVCASSNSCIPA 1437
PC D I + + C P N C + +CS+ + S C+
Sbjct: 3811 PCGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCV-- 3868
Query: 1438 HQRCDGFADCMDFQLDESSC 1457
CD +FQ ++C
Sbjct: 3869 ---CD-----QNFQERNNTC 3880
Score = 52.0 bits (123), Expect = 4e-06
Identities = 43/136 (31%), Positives = 56/136 (41%), Gaps = 26/136 (19%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSD----------EMDCPLNPTPPLCSNMEF 1387
C+ +F C + CV S CDG DC D SD E+ CPLN L
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACL------ 85
Query: 1388 PCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSN-GALVCASSNSCIPAHQRC---DG 1443
T++C+ LC+GV DC DE + + SN L C + + RC DG
Sbjct: 86 --GTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDG 143
Query: 1444 FADCMDFQLDESSCSD 1459
F + D SC D
Sbjct: 144 F----EITEDGRSCKD 155
Score = 51.2 bits (121), Expect = 8e-06
Identities = 64/256 (25%), Positives = 89/256 (34%), Gaps = 57/256 (22%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEAS--CVMEVCSFEKRSLCKWYQPI 469
PH C EF C++ HCI+ KCD DC D SDE S C C + + C+ + I
Sbjct: 842 PHICKAGEFRCKNR-HCIQARWKCDGDDDCLDGSDEDSVNCFNHSCP-DDQFKCQNNRCI 899
Query: 470 PVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADIL 529
P L D N + E N
Sbjct: 900 PKRWLCDG-------ANDCGSNEDESNQ-------------------------------- 920
Query: 530 TPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGI 589
+ T C + ++ NG + + ++D+ G Q + E F
Sbjct: 921 ----TCTARTCQVDQFSCGNGRCIPRAWLCDREDDC--------GDQTDEMASCE-FPTC 967
Query: 590 RSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCD 649
TQ V ++ R IS DD D S + C D++F C++ CI CD
Sbjct: 968 EPLTQFVCKSGRCISSKWHCDSDD-DCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACD 1026
Query: 650 FVNDCADNSDETTFIC 665
NDC D SDE C
Sbjct: 1027 GDNDCGDFSDEAQINC 1042
Score = 50.1 bits (118), Expect = 2e-05
Identities = 34/99 (34%), Positives = 43/99 (43%), Gaps = 12/99 (12%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------A 225
DD E P SC D+F C+ T+ CI KL +CD DC D +DE NC
Sbjct: 3420 DDCGDEEDERDCPENSCSP-DYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGP 3478
Query: 226 PELQCNFETGI-----CNWEQDAKDDFDWTRNQGPTPTL 259
E QC I C+ + D D+ D + T TL
Sbjct: 3479 HEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTL 3517
Score = 49.7 bits (117), Expect = 2e-05
Identities = 69/282 (24%), Positives = 105/282 (37%), Gaps = 37/282 (13%)
Query: 409 TLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVCSFEKRSLCKWYQ 467
T C ++F C +G CI + CD + DC D++DE ASC C + +CK +
Sbjct: 921 TCTARTCQVDQFSC-GNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGR 979
Query: 468 PIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTAD 527
I DS+ + + H +++ + W D+ G F D A
Sbjct: 980 CISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQ 1039
Query: 528 ILTPIISLTGPK-CT-LVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQ----GAQWK 581
I + P C F H +G N LW G++ G+ K
Sbjct: 1040 INCTKEEIHSPAGCNGNEFQCHPDG-------------NCVPDLWRCDGEKDCEDGSDEK 1086
Query: 582 RAEVFLGIRSHTQ--IVFRAKRGISYI----GDVAVDDISFQ-DCSPLLSPERKCTDHEF 634
+ + H + R I+ GD+ +D S + DC L C +
Sbjct: 1087 GCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFL-----CGPPKH 1141
Query: 635 MCAN--KHCIAKDKLCDFVNDCADNSDETTFI--CRTSSGRC 672
CAN C+ +KLC+ DC D SDE C ++G C
Sbjct: 1142 PCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSLNNGGC 1183
Score = 49.7 bits (117), Expect = 2e-05
Identities = 29/83 (34%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 612 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI----CRT 667
D++S C+P C ++ FMC NK CI K +CD +DC D SDE+ C T
Sbjct: 2792 DELSTAGCAP----NNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGT 2847
Query: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
C L + + + D DFD
Sbjct: 2848 EEFSCADGRCLLNTQWQCDGDFD 2870
Score = 48.9 bits (115), Expect = 4e-05
Identities = 31/94 (32%), Positives = 42/94 (44%), Gaps = 16/94 (17%)
Query: 609 VAVDDISFQDCSPLLSPERK-CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT----- 662
V +D D S + ++K C HEF C N +CI CD NDC+DNSDE
Sbjct: 3455 VCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQT 3514
Query: 663 -----FICR-----TSSGRCDFEFDLCSWKQEKD 686
F+C +S CD +FD E++
Sbjct: 3515 CTLKDFLCANGDCVSSRFWCDGDFDCADGSDERN 3548
Score = 48.1 bits (113), Expect = 6e-05
Identities = 74/298 (24%), Positives = 112/298 (37%), Gaps = 65/298 (21%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV------NCA 225
+D + CT A +C+ +D F C + R CI + LCD DDCGD+TDE+ C
Sbjct: 915 EDESNQTCT----ARTCQ-VDQFSCGNGR-CIPRAWLCDREDDCGDQTDEMASCEFPTCE 968
Query: 226 PELQCNFETGIC---NWEQDAKDDF-DWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIES 281
P Q ++G C W D+ DD D + G + + ++ GH+
Sbjct: 969 PLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGD 1028
Query: 282 SEPQAFQDSAALLSPILNATDTKGCT-FRFYYHMFGKRIYRLAIYQRIW----------- 329
++ F D A + GC F H G + +W
Sbjct: 1029 NDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCV------PDLWRCDGEKDCEDG 1082
Query: 330 SDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGFTGDIAIDDLSFMDCTL 389
SD +G N R S + + +A V D GDI +D S D
Sbjct: 1083 SDEKG-------CNGTIRLCDHKTKFSCWSTGRCINKAWVCD---GDIDCEDQSDED--- 1129
Query: 390 YPGNLPADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
+ + L PP+ H C ++ + C++ + C+ K DCPD SDE
Sbjct: 1130 ---DCDSFLCGPPK---------HPCANDTSV------CLQPEKLCNGKKDCPDGSDE 1169
Score = 48.1 bits (113), Expect = 6e-05
Identities = 61/259 (23%), Positives = 106/259 (40%), Gaps = 32/259 (12%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV 471
P CT +F+C ++G C+ CD +DC D SDE +C E + + C Q IP
Sbjct: 3512 PQTCTLKDFLC-ANGDCVSSRFWCDGDFDCADGSDERNC--ETSCSKDQFRCSNGQCIPA 3568
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHR-----PSVDHTQN--TTDGWYLYADSSNGKFGD 524
+W +GE+ P+ + +DG + NG++ D
Sbjct: 3569 ---------KWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEY-D 3618
Query: 525 TADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKK-DNVTSKLWAQTGQQGAQWKRA 583
AD + +T +C + N A ++ L + + ++G RA
Sbjct: 3619 CADGSDEMDCVT--ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRA 3676
Query: 584 EVFLGIRSHTQIVFRAKRGISYIGDVAVD--DISFQDCSPLLSPERKCTDHEFMCANKHC 641
+ FL S ++ F G GD + + D+ + P P R C + N+ C
Sbjct: 3677 DEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHR-CRN------NRIC 3729
Query: 642 IAKDKLCDFVNDCADNSDE 660
+ +++C+ +++C DNSDE
Sbjct: 3730 LQSEQMCNGIDECGDNSDE 3748
Score = 47.8 bits (112), Expect = 8e-05
Identities = 35/120 (29%), Positives = 50/120 (41%), Gaps = 12/120 (10%)
Query: 1307 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1366
DG+ D D+ P+C + C + F C +C+P G CD +DC D
Sbjct: 2866 DGDFDCPDHSDEAPLNPKCKSA------EQSCNSSFFMC-KNGRCIPSGGLCDNKDDCGD 2918
Query: 1367 GSDEMDCPLNPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCHFNEDELICSN-KSCSNG 1424
GSDE +C +N S CS D + +P C P +D C + CS+G
Sbjct: 2919 GSDERNCHIN---ECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSG 2975
Score = 46.2 bits (108), Expect = 2e-04
Identities = 19/45 (42%), Positives = 23/45 (51%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCD 673
C D +F C N CI K LCD NDC N DE+ C + + D
Sbjct: 886 CPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVD 930
Score = 45.8 bits (107), Expect = 3e-04
Identities = 74/320 (23%), Positives = 107/320 (33%), Gaps = 48/320 (15%)
Query: 407 PVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWY 466
P P C F C + G C CD + DC D SDE +C VC + K
Sbjct: 3349 PDDCPEFRCQPGRFQCGT-GLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQ 3407
Query: 467 QPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTA 526
+ IPV+L NG EE+ R D +N+ Y + T
Sbjct: 3408 KCIPVNL----------RCNGQDDCGDEEDER---DCPENSCSPDYFQCKT-------TK 3447
Query: 527 DILTPI-ISLTGPKCT-LVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAE 584
++ + + P C + + T G + K +N W Q E
Sbjct: 3448 HCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDE 3507
Query: 585 VFLGIRSHTQIVFRAKRGISYIGDVAVD-DISFQDCSPLLSPERKCTDHEFMCANKHCIA 643
++ T F G D D D S + E C+ +F C+N CI
Sbjct: 3508 ENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNGQCIP 3567
Query: 644 KDKLCDFVNDCADNSDETT------------FICR-----TSSGRCDFEFDLCSWKQE-- 684
CD DC DE + +IC ++S +C+ E+D E
Sbjct: 3568 AKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMD 3627
Query: 685 -----KDEDFDWNLKASSIP 699
K++ F KA IP
Sbjct: 3628 CVTECKEDQFRCKNKAHCIP 3647
Score = 45.8 bits (107), Expect = 3e-04
Identities = 28/79 (35%), Positives = 37/79 (46%), Gaps = 12/79 (15%)
Query: 602 GISYIGDVAVDDISFQDCSPLLSPE-RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
GI GD + +D C L+ + R C EF C+NK CI D CD ++DC D SDE
Sbjct: 3738 GIDECGDNSDED----HCGGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDE 3793
Query: 661 -------TTFICRTSSGRC 672
T + C + C
Sbjct: 3794 QGCRIAPTEYTCEDNVNPC 3812
Score = 45.1 bits (105), Expect = 5e-04
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 605 YIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---- 660
++ D A D S +D S R C +F C N CI + LCD +DC D +DE
Sbjct: 903 WLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASC 962
Query: 661 --------TTFICRTSSGRCDFEFDLCSWKQEKDED 688
T F+C+ SGRC W + D+D
Sbjct: 963 EFPTCEPLTQFVCK--SGRCISS----KWHCDSDDD 992
Score = 44.3 bits (103), Expect = 0.001
Identities = 26/78 (33%), Positives = 35/78 (44%), Gaps = 12/78 (15%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAH------YTSTTGSCNFETSSGN 1172
C +T F+C+ +CI+S CD DC SDE C H + ++G C G+
Sbjct: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRC----IPGH 1022
Query: 1173 WTTACSLTQDSEDDLDWA 1190
W AC D D D A
Sbjct: 1023 W--ACDGDNDCGDFSDEA 1038
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/65 (35%), Positives = 28/65 (43%), Gaps = 3/65 (4%)
Query: 611 VDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---TTFICRT 667
VDD P PE +C F C C +CD NDC DNSDE T +C +
Sbjct: 3339 VDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLS 3398
Query: 668 SSGRC 672
+C
Sbjct: 3399 GQFKC 3403
Score = 42.7 bits (99), Expect = 0.003
Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 11/74 (14%)
Query: 628 KCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDETTF-----ICRT-----SSGRCDFEF 676
+C + +F C NK HCI LCD ++DC D SDE ICR ++ C F
Sbjct: 3631 ECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHF 3690
Query: 677 DLCSWKQEKDEDFD 690
+C + + ++ D
Sbjct: 3691 WVCDGEDDCGDNSD 3704
Score = 42.7 bits (99), Expect = 0.003
Identities = 17/40 (42%), Positives = 24/40 (60%), Gaps = 1/40 (2%)
Query: 855 CHNGK-CYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWC 893
C N + C + EQ CN +D CGDN+ E+ CG T++ C
Sbjct: 3723 CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPC 3762
Score = 42.4 bits (98), Expect = 0.004
Identities = 23/54 (42%), Positives = 24/54 (44%), Gaps = 3/54 (5%)
Query: 622 LLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---TTFICRTSSGRC 672
L R C C N+ CI KLCD NDC DNSDE C T RC
Sbjct: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRC 2598
Score = 42.0 bits (97), Expect = 0.005
Identities = 18/37 (48%), Positives = 20/37 (54%)
Query: 624 SPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
S E+ C FMC N CI LCD +DC D SDE
Sbjct: 2886 SAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE 2922
Score = 41.6 bits (96), Expect = 0.006
Identities = 73/305 (23%), Positives = 102/305 (33%), Gaps = 54/305 (17%)
Query: 198 HTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI-----CNWEQDAKDD 246
+ R CI +LCD +DCGD +DE++C E +C T I CN D D
Sbjct: 2560 YNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADA 2619
Query: 247 FDWTRNQGPTPTLNTGPMKDNTLGTAKGHY-------LYIESSEPQAFQDSAALLSPILN 299
D +N T + + T G + + +I S L P+ N
Sbjct: 2620 SD-EKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQN 2678
Query: 300 ATDTKGCTFRFYYHMFGKRIYRLAIY--QRIWSDSRGQL------LWQIFGNQGNRWIRK 351
C ++ G+ I I Q+ D R + W F + I K
Sbjct: 2679 ---KHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISK 2735
Query: 352 HLNISSRQPFQILVEASVGDGFTGDIAIDD-----LSFMDCTLYPGNLP--------ADL 398
H E GDG +I C +P D
Sbjct: 2736 HWICDG--------EDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDC 2787
Query: 399 PTPPETSVPVTLPPHN-CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA-SCVMEVCS 456
P + P+N C +N F+C + CI K CD DC D SDE+ C C
Sbjct: 2788 PDGSDELSTAGCAPNNTCDENAFMCHNK-VCIPKQFVCDHDDDCGDGSDESPQCGYRQCG 2846
Query: 457 FEKRS 461
E+ S
Sbjct: 2847 TEEFS 2851
Score = 41.6 bits (96), Expect = 0.006
Identities = 26/67 (38%), Positives = 33/67 (49%), Gaps = 13/67 (19%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC---NFETG---------ICNWEQ 241
F C+ T CI CD VDDCGD +DE + PE +C F+ G IC+ E
Sbjct: 3322 FRCK-TDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGEN 3380
Query: 242 DAKDDFD 248
D D+ D
Sbjct: 3381 DCGDNSD 3387
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/59 (38%), Positives = 32/59 (54%), Gaps = 2/59 (3%)
Query: 414 NCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKW-YQPIPV 471
+C + F+C++ G CI CD K DC D SDE +C + C +K S C Q +PV
Sbjct: 2890 SCNSSFFMCKN-GRCIPSGGLCDNKDDCGDGSDERNCHINECLSKKVSGCSQDCQDLPV 2947
Score = 40.0 bits (92), Expect = 0.017
Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 14/67 (20%)
Query: 196 CRHTRACIEKLRLCDLVDDCGDRTDEVNC--------------APELQCNFETGICNWEQ 241
C T C+ +CD +DCGD +DE+ C P +C T IC+ ++
Sbjct: 2646 CNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQK 2705
Query: 242 DAKDDFD 248
D +D D
Sbjct: 2706 DCEDGRD 2712
Score = 40.0 bits (92), Expect = 0.017
Identities = 15/40 (37%), Positives = 25/40 (62%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
+ C+ ++F C+ + CI+K +CD +DC D DE+ IC
Sbjct: 2717 DSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSIC 2756
Score = 40.0 bits (92), Expect = 0.017
Identities = 24/70 (34%), Positives = 31/70 (44%), Gaps = 13/70 (18%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC--------APELQCN-----FETGICN 238
D F C++ CI LCD + DC D +DE NC A E CN +C+
Sbjct: 3635 DQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLCKLHFWVCD 3694
Query: 239 WEQDAKDDFD 248
E D D+ D
Sbjct: 3695 GEDDCGDNSD 3704
Score = 40.0 bits (92), Expect = 0.017
Identities = 13/33 (39%), Positives = 24/33 (72%)
Query: 196 CRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL 228
CR+ R C++ ++C+ +D+CGD +DE +C +L
Sbjct: 3723 CRNNRICLQSEQMCNGIDECGDNSDEDHCGGKL 3755
Score = 39.7 bits (91), Expect = 0.023
Identities = 19/50 (38%), Positives = 29/50 (58%), Gaps = 3/50 (6%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVN---CAPELQCNFETGICN 238
D F C+ +RAC+ + LCD DC D +DE++ CAP C+ +C+
Sbjct: 2764 DMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCH 2813
Score = 39.3 bits (90), Expect = 0.030
Identities = 28/93 (30%), Positives = 38/93 (40%), Gaps = 12/93 (12%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCN 231
D++ C P +C+ + F C H + CI K +CD DDCGD +DE QC
Sbjct: 2792 DELSTAGCA---PNNTCDE-NAFMC-HNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCG 2846
Query: 232 FETGIC-------NWEQDAKDDFDWTRNQGPTP 257
E C N + DFD + P
Sbjct: 2847 TEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAP 2879
Score = 38.1 bits (87), Expect = 0.066
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 12/58 (20%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCSWKQ 683
+ KC ++ F C + CI +CD DC D DE F C +S CSW Q
Sbjct: 2679 KHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDE--FHCDSS----------CSWNQ 2724
Score = 38.1 bits (87), Expect = 0.066
Identities = 19/56 (33%), Positives = 29/56 (51%), Gaps = 3/56 (5%)
Query: 627 RKCTDHEFMCANKHCIAKDKL-CDFVNDCADNSDETTF--ICRTSSGRCDFEFDLC 679
R+C EF CA+ C+ + CD DC D+SDE C+++ C+ F +C
Sbjct: 2843 RQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMC 2898
Score = 38.1 bits (87), Expect = 0.066
Identities = 15/30 (50%), Positives = 20/30 (66%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
F+C++ +CI S LCD K DC SDE +C
Sbjct: 2896 FMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 37.7 bits (86), Expect = 0.087
Identities = 18/35 (51%), Positives = 22/35 (62%), Gaps = 2/35 (5%)
Query: 415 CTDNEFICRSDGHCIEKMQ-KCDFKYDCPDKSDEA 448
C EF C +DG C+ Q +CD +DCPD SDEA
Sbjct: 2845 CGTEEFSC-ADGRCLLNTQWQCDGDFDCPDHSDEA 2878
Score = 37.7 bits (86), Expect = 0.087
Identities = 16/37 (43%), Positives = 20/37 (54%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
C EF+C N C +CD +DC DNSDE +C
Sbjct: 3674 CRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 3710
Score = 37.4 bits (85), Expect = 0.11
Identities = 17/49 (34%), Positives = 23/49 (46%), Gaps = 3/49 (6%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLC 463
C EF+C C+ + CD DCPD SDE+ ++ C E C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES---LDTCPEEVEIKC 77
Score = 37.4 bits (85), Expect = 0.11
Identities = 19/39 (48%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Query: 186 ESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
+SC F C++ R CI LCD DDCGD +DE NC
Sbjct: 2889 QSCNS-SFFMCKNGR-CIPSGGLCDNKDDCGDGSDERNC 2925
Score = 36.6 bits (83), Expect = 0.19
Identities = 17/43 (39%), Positives = 19/43 (44%)
Query: 633 EFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE 675
EF C N CI CD + C D SDE C S R F+
Sbjct: 2515 EFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFK 2557
Score = 36.6 bits (83), Expect = 0.19
Identities = 21/55 (38%), Positives = 23/55 (41%), Gaps = 10/55 (18%)
Query: 413 HNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQ 467
H C +N F C S G CI CD + DC D DE C S C W Q
Sbjct: 2680 HKCEENYFSCPS-GRCILNTWICDGQKDCEDGRDEFHC---------DSSCSWNQ 2724
Score = 35.8 bits (81), Expect = 0.33
Identities = 21/63 (33%), Positives = 30/63 (47%), Gaps = 5/63 (7%)
Query: 1111 SVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFET-S 1169
SV + CP+ F C++ +CI LCD DC DE ++ T T +C + S
Sbjct: 878 SVNCFNHSCPD-DQFKCQNNRCIPKRWLCDGANDCGSNEDE---SNQTCTARTCQVDQFS 933
Query: 1170 SGN 1172
GN
Sbjct: 934 CGN 936
Score = 35.8 bits (81), Expect = 0.33
Identities = 28/97 (28%), Positives = 38/97 (39%), Gaps = 25/97 (25%)
Query: 186 ESCE-GLDHFWCRHT----------RACIEKLRLCDLVDDCGDRTDE-------VNCAPE 227
+ CE G D F C + + CI K +CD DDCGD DE + CA +
Sbjct: 2705 KDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAAD 2764
Query: 228 L-------QCNFETGICNWEQDAKDDFDWTRNQGPTP 257
+ C +C+ E+D D D G P
Sbjct: 2765 MFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAP 2801
Score = 35.8 bits (81), Expect = 0.33
Identities = 15/31 (48%), Positives = 17/31 (54%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
+F C +KKCI L CD DC SDE C
Sbjct: 3766 EFACSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 35.4 bits (80), Expect = 0.43
Identities = 17/34 (50%), Positives = 21/34 (61%), Gaps = 1/34 (2%)
Query: 414 NCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
NCT ++F C++D CI KCD DC D SDE
Sbjct: 3316 NCTASQFRCKTD-KCIPFWWKCDTVDDCGDGSDE 3348
Score = 35.0 bits (79), Expect = 0.56
Identities = 18/48 (37%), Positives = 22/48 (45%), Gaps = 4/48 (8%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----TTFICRTSSGRC 672
CT +F C CI CD V+DC D SDE F C+ +C
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQC 3364
Score = 34.7 bits (78), Expect = 0.73
Identities = 16/47 (34%), Positives = 23/47 (48%), Gaps = 1/47 (2%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSG 1171
F+C +K CI +CD+ DC SDE+ Y G+ F + G
Sbjct: 2810 FMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQ-CGTEEFSCADG 2855
Score = 34.3 bits (77), Expect = 0.96
Identities = 23/70 (32%), Positives = 29/70 (41%), Gaps = 14/70 (20%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVN--CAPEL-----------QCNFETGICN 238
D F C++ R CI K LCD +DCG DE N C +C +C+
Sbjct: 889 DQFKCQNNR-CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCD 947
Query: 239 WEQDAKDDFD 248
E D D D
Sbjct: 948 REDDCGDQTD 957
Score = 34.3 bits (77), Expect = 0.96
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 3/55 (5%)
Query: 833 DSVQEELAVPLPTGFC-PLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSC 886
D E + PT C PL C +G+C + C+ D+CGD + E C SC
Sbjct: 954 DQTDEMASCEFPT--CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSC 1006
Score = 33.9 bits (76), Expect = 1.3
Identities = 18/66 (27%), Positives = 30/66 (45%), Gaps = 1/66 (1%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLT 1180
++ F C + +CI LCD + DC ++DE + + F SG ++
Sbjct: 928 QVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISS-KWH 986
Query: 1181 QDSEDD 1186
DS+DD
Sbjct: 987 CDSDDD 992
Score = 33.9 bits (76), Expect = 1.3
Identities = 12/35 (34%), Positives = 21/35 (60%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKC 882
C G++ C+N +C + C+ ++CGDN+ E C
Sbjct: 2552 CRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDC 2586
Score = 33.9 bits (76), Expect = 1.3
Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 1118 LCPEITDFLCRDKK-CIASHLLCDYKPDCSGRSDEAHC 1154
LCP CR+ + C+ S +C+ +C SDE HC
Sbjct: 3714 LCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/41 (36%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 626 ERKCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDETTFIC 665
++ C EF+C + C+++ LCD DC D+SDE+ C
Sbjct: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTC 69
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/32 (46%), Positives = 18/32 (56%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C EF CA+ CI + C+ DCAD SDE
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDE 2622
Score = 33.5 bits (75), Expect = 1.6
Identities = 20/49 (40%), Positives = 24/49 (48%), Gaps = 4/49 (8%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC--AP-ELQCNFETGIC 237
D F C + + CI CD +DDCGD +DE C AP E C C
Sbjct: 3765 DEFACSNKK-CIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPC 3812
Score = 33.1 bits (74), Expect = 2.1
Identities = 18/61 (29%), Positives = 27/61 (44%), Gaps = 1/61 (1%)
Query: 837 EELAVPLPTGF-CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGW 895
+EL P+ C Y C +G+C C+ +C D E C SSC++ + C
Sbjct: 2670 DELKCPVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSA 2729
Query: 896 Q 896
Q
Sbjct: 2730 Q 2730
Score = 33.1 bits (74), Expect = 2.1
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCN 231
F C + CI C+ DDCGD DE +C PE C+
Sbjct: 3401 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDC-PENSCS 3437
Score = 32.7 bits (73), Expect = 2.8
Identities = 18/51 (35%), Positives = 25/51 (49%), Gaps = 2/51 (3%)
Query: 1103 PNRRSALLSVGEISELCPEITDFLCRDK-KCIASHLLCDYKPDCSGRSDEA 1152
P R + +LC + +FLC D C++ LCD PDC SDE+
Sbjct: 16 PIARVLTVGADRDQQLC-DPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES 65
Score = 32.7 bits (73), Expect = 2.8
Identities = 16/52 (30%), Positives = 23/52 (44%), Gaps = 1/52 (1%)
Query: 629 CTDHEFMC-ANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLC 679
C F C ++ C+ + LCD DC D SDE + + CD +C
Sbjct: 2761 CAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMC 2812
Score = 32.7 bits (73), Expect = 2.8
Identities = 25/70 (35%), Positives = 33/70 (47%), Gaps = 10/70 (14%)
Query: 163 GIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV 222
GI+D V D+ ENC C D F C ++ C +CD DDCGD +DE
Sbjct: 3654 GIHDCVDGSDE---ENCERG--GNICRA-DEFLCNNS-LCKLHFWVCDGEDDCGDNSDE- 3705
Query: 223 NCAPELQCNF 232
AP++ F
Sbjct: 3706 --APDMCVKF 3713
Score = 32.7 bits (73), Expect = 2.8
Identities = 11/28 (39%), Positives = 17/28 (60%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKC 882
C N KC ++ C+ +D+CGD + E C
Sbjct: 3769 CSNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 32.3 bits (72), Expect = 3.6
Identities = 17/43 (39%), Positives = 21/43 (48%), Gaps = 1/43 (2%)
Query: 408 VTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
+T C +EF C S+ CI +CD DC D SDE C
Sbjct: 3755 LTYKARPCKKDEFAC-SNKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Score = 32.0 bits (71), Expect = 4.8
Identities = 20/61 (32%), Positives = 27/61 (44%)
Query: 180 TLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNW 239
T P E L+H C T C+ +LC+ V DC D DE EL N + C +
Sbjct: 68 TCPEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQY 127
Query: 240 E 240
+
Sbjct: 128 K 128
Score = 32.0 bits (71), Expect = 4.8
Identities = 22/74 (29%), Positives = 28/74 (37%), Gaps = 12/74 (16%)
Query: 1124 DFLCR-DKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTT------- 1175
+F C D C+ CD + DC SDE C T C+ +T W+T
Sbjct: 1057 EFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGC---NGTIRLCDHKTKFSCWSTGRCINKA 1113
Query: 1176 -ACSLTQDSEDDLD 1188
C D ED D
Sbjct: 1114 WVCDGDIDCEDQSD 1127
Score = 32.0 bits (71), Expect = 4.8
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 13/59 (22%)
Query: 199 TRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWTRNQGPTP 257
T C +CD +DCGD +DE+NC +T +C F T+NQ P
Sbjct: 3366 TGLCALPAFICDGENDCGDNSDELNC--------DTHVC-----LSGQFKCTKNQKCIP 3411
Score = 31.6 bits (70), Expect = 6.2
Identities = 15/51 (29%), Positives = 22/51 (43%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKW 465
C N C C+ Q C+ DCPD DE E+ S ++ C++
Sbjct: 77 CPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQY 127
Score = 31.6 bits (70), Expect = 6.2
Identities = 12/35 (34%), Positives = 17/35 (48%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKC 882
C + C NG+C C+ D+CGD + E C
Sbjct: 2891 CNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC 2925
Score = 31.6 bits (70), Expect = 6.2
Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 6/72 (8%)
Query: 1119 CPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWT 1174
CPE F C C +CD + DC SDE +C + +G F+ +
Sbjct: 3352 CPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSG--QFKCTKNQKC 3409
Query: 1175 TACSLTQDSEDD 1186
+L + +DD
Sbjct: 3410 IPVNLRCNGQDD 3421
Score = 31.2 bits (69), Expect = 8.1
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 3/41 (7%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTF 888
C + C NG+C C+ D+CGD T E +SC F
Sbjct: 927 CQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEM---ASCEF 964
Score = 31.2 bits (69), Expect = 8.1
Identities = 19/71 (26%), Positives = 25/71 (35%), Gaps = 14/71 (19%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNT-------------GENKCGSS-CTFEKGWC 893
C C KC C+ VD+CGD + G +CG+ C C
Sbjct: 3317 CTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFIC 3376
Query: 894 GWQNSQADNFD 904
+N DN D
Sbjct: 3377 DGENDCGDNSD 3387
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 97.4 bits (241), Expect = 9e-20
Identities = 98/349 (28%), Positives = 135/349 (38%), Gaps = 45/349 (12%)
Query: 1123 TDFLC-RDKKCIASHLLCDYKPDCSGRSDE-AHCAHYTSTTGSCNFETSSGNWTTACSLT 1180
T FLC ++KCI CD + DCS SDE A C G F+ S GN T+ +L
Sbjct: 3515 TQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQ--FQCSDGNCTSPQTLC 3572
Query: 1181 QDSEDDLDWAIGSRIPAKALIPDSDH--------TPGSGQHFLYV----NSSGSKEGSVA 1228
++ D + R+ + DS+ P S Q + NS +
Sbjct: 3573 NAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCAS 3632
Query: 1229 RITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYG 1288
R F + G C + W +D G IEE + + Y
Sbjct: 3633 RTCRPGQFRCANGRCIPQAWKCDVD-NDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYR 3691
Query: 1289 SVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYT 1348
+P A +G +D D S C PV C+
Sbjct: 3692 CIPKW----------AVCNGVDDC----RDNSDEQGCEERTCHPVGDFRCKNHH------ 3731
Query: 1349 LQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCH 1408
C+PL +CDG DC D SDE +C P C+ EF C +CIPS +CD DC
Sbjct: 3732 --CIPLRWQCDGQNDCGDNSDEENC----APRECTESEFRCVNQQCIPSRWICDHYNDCG 3785
Query: 1409 FNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
N DE C ++C C S + C+ + +CDG ADC+D DE+ C
Sbjct: 3786 DNSDERDCEMRTCHPEYFQCTSGH-CVHSELKCDGSADCLDAS-DEADC 3832
Score = 93.2 bits (230), Expect = 2e-18
Identities = 62/178 (34%), Positives = 81/178 (45%), Gaps = 22/178 (12%)
Query: 1318 DISFT----PECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC 1373
D+SF +CV G C A QF C +C+ ++ +CDG DC D SDE C
Sbjct: 1163 DLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Query: 1374 PLNPTPPLCSNMEFPCSTDE-CIPSLLLCDGVPDCHFNEDE-LICSNKSCSNGALVCASS 1431
P P P +C + EF C D CIP+ CDG PDC + DE C K+C + C +
Sbjct: 1223 PTRP-PGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNG 1281
Query: 1432 NSCIPAHQRCDGFADCMDFQLDESSC--------SDTWTLLGIGLAFLMTHITVAVLC 1481
N CI CD DC D DE C S W LG + + ++V+C
Sbjct: 1282 N-CIHRAWLCDRDNDCGDMS-DEKDCPTQPFRCPSWQWQCLGHNIC-----VNLSVVC 1332
Score = 90.1 bits (222), Expect = 1e-17
Identities = 48/124 (38%), Positives = 64/124 (51%), Gaps = 10/124 (8%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC-STDECIP 1396
C+ QF+C +C+ LS CDG +DC+DGSDE+ C LN C+ +F C S D+CI
Sbjct: 1149 CQPSQFNCP-NHRCIDLSFVCDGDKDCVDGSDEVGCVLN-----CTASQFKCASGDKCIG 1202
Query: 1397 SLLLCDGVPDCHFNEDELICSNK---SCSNGALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
CDGV DC N DE C + C + C CIP CDG DC+ +
Sbjct: 1203 VTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDE 1262
Query: 1454 ESSC 1457
++C
Sbjct: 1263 HNAC 1266
Score = 87.0 bits (214), Expect = 1e-16
Identities = 46/122 (37%), Positives = 62/122 (50%), Gaps = 8/122 (6%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD-CPLNPTPPLCSNMEFPCSTDECIP 1396
C + QF C +C+P+ KCDG +DC DGSDE+ CP C +F CS C
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQR----FCRLGQFQCSDGNCTS 3567
Query: 1397 SLLLCDGVPDC--HFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
LC+ +C +ED L+C N C + CA+ CIP +CD F DC D ++
Sbjct: 3568 PQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKR-CIPESWQCDTFNDCEDNSDED 3626
Query: 1455 SS 1456
SS
Sbjct: 3627 SS 3628
Score = 86.3 bits (212), Expect = 2e-16
Identities = 45/114 (39%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C F+C +CV S +CD + DC DGSDE C + EF C+ CIP
Sbjct: 2741 CSPTAFTCANG-RCVQYSYRCDYYNDCGDGSDEAGCLFRDCN---ATTEFMCNNRRCIPR 2796
Query: 1398 LLLCDGVPDCHFNE--DELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
+C+GV +CH N DE C +++C +G C +SN CIP CDG DC D
Sbjct: 2797 EFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGD 2850
Score = 84.3 bits (207), Expect = 8e-16
Identities = 43/96 (44%), Positives = 53/96 (55%), Gaps = 8/96 (8%)
Query: 1368 SDEMDCPLNPT--PPL--CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICS--NKSC 1421
S+ + C +PT PP C FPC C+P+ LCDGV DCH N DE +C N +C
Sbjct: 1008 SNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTC 1067
Query: 1422 SNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
S+ A C CIPAH RCD DC+D DE +C
Sbjct: 1068 SSSAFTC-GHGECIPAHWRCDKRNDCVDGS-DEHNC 1101
Score = 83.2 bits (204), Expect = 2e-15
Identities = 47/123 (38%), Positives = 61/123 (49%), Gaps = 4/123 (3%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNM-EFPCSTD-ECI 1395
C QF C +C+P + KCD DC D SDE + LC N EF C T+ CI
Sbjct: 3635 CRPGQFRCANG-RCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCI 3693
Query: 1396 PSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1455
P +C+GV DC N DE C ++C ++ CIP +CDG DC D DE
Sbjct: 3694 PKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGD-NSDEE 3752
Query: 1456 SCS 1458
+C+
Sbjct: 3753 NCA 3755
Score = 82.8 bits (203), Expect = 2e-15
Identities = 47/123 (38%), Positives = 61/123 (49%), Gaps = 9/123 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE-MDCPLNPTPPLCSNMEFPCSTDECIP 1396
C+ F C QC+P S CD +DC DGSDE DC + CS+ + CS +CIP
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDC----SQSTCSSHQITCSNGQCIP 122
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
S CD V DC DE C +C L C + +C Q+CD DC D DE +
Sbjct: 123 SEYRCDHVRDCPDGADENDCQYPTCEQ--LTC-DNGACYNTSQKCDWKVDCRD-SSDEIN 178
Query: 1457 CSD 1459
C++
Sbjct: 179 CTE 181
Score = 82.4 bits (202), Expect = 3e-15
Identities = 45/128 (35%), Positives = 65/128 (50%), Gaps = 9/128 (7%)
Query: 1332 PVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCST 1391
P C++ F C + C+P +CDG +DC D +DE+ C + C F C +
Sbjct: 22 PASGQECDSAHFRC-GSGHCIPADWRCDGTKDCSDDADEIGCAV----VTCQQGYFKCQS 76
Query: 1392 D-ECIPSLLLCDGVPDCHFNEDELI-CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
+ +CIP+ +CD DC DE CS +CS+ + C S+ CIP+ RCD DC D
Sbjct: 77 EGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITC-SNGQCIPSEYRCDHVRDCPD 135
Query: 1450 FQLDESSC 1457
DE+ C
Sbjct: 136 -GADENDC 142
Score = 81.3 bits (199), Expect = 7e-15
Identities = 43/115 (37%), Positives = 54/115 (46%), Gaps = 4/115 (3%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLN-PTPPLCSNMEFPCSTDECIP 1396
C + F C + CV KCDG DC+D SDE DCP P C F C CIP
Sbjct: 3798 CHPEYFQCT-SGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIP 3856
Query: 1397 SLLLCDGVPDCHFNEDE--LICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
CDG DC DE +C + C++ +N CI +H+ C+G DC D
Sbjct: 3857 PYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGD 3911
Score = 79.7 bits (195), Expect = 2e-14
Identities = 42/121 (34%), Positives = 61/121 (50%), Gaps = 5/121 (4%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C + F+C + +C+P +CD DC+DGSDE +CP + P C + ++ C +CI
Sbjct: 1067 CSSSAFTCGHG-ECIPAHWRCDKRNDCVDGSDEHNCPTH-APASCLDTQYTCDNHQCISK 1124
Query: 1398 LLLCDGVPDCHFNEDELIC-SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
+CD DC DE C S ++C C + + CI CDG DC+D DE
Sbjct: 1125 NWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPN-HRCIDLSFVCDGDKDCVDGS-DEVG 1182
Query: 1457 C 1457
C
Sbjct: 1183 C 1183
Score = 76.6 bits (187), Expect = 2e-13
Identities = 43/128 (33%), Positives = 58/128 (45%), Gaps = 9/128 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C + +F C + +C+P CD DC D SDE + C EF C CIPS
Sbjct: 2864 CSSSEFQCA-SGRCIPQHWYCDQETDCFDASDE-PASCGHSERTCLADEFKCDGGRCIPS 2921
Query: 1398 LLLCDGVPDCHFNEDE---LICSNKSCSNGALVCASSNS----CIPAHQRCDGFADCMDF 1450
+CDG DC DE C N++CS+ +C + CIP CDG DC D
Sbjct: 2922 EWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDG 2981
Query: 1451 QLDESSCS 1458
+ +C+
Sbjct: 2982 YDENQNCT 2989
Score = 76.6 bits (187), Expect = 2e-13
Identities = 42/120 (35%), Positives = 55/120 (45%), Gaps = 11/120 (9%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDEC 1394
P C +F C+ QC+P CD + DC D SDE DC + C F C++ C
Sbjct: 3756 PRECTESEFRCV-NQQCIPSRWICDHYNDCGDNSDERDCEMR----TCHPEYFQCTSGHC 3810
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNK-----SCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
+ S L CDG DC DE C + C C ++ CIP + +CDG DC D
Sbjct: 3811 VHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFEC-KNHVCIPPYWKCDGDDDCGD 3869
Score = 76.3 bits (186), Expect = 2e-13
Identities = 47/134 (35%), Positives = 57/134 (42%), Gaps = 16/134 (11%)
Query: 1333 VQPSPCEADQFSCIYTL---------QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCS 1383
V+ P AD+ C Y C S KCD DC D SDE++C +C
Sbjct: 130 VRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-----EICL 184
Query: 1384 NMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDG 1443
+ EF C ECIP +CD DC DE C+ +C C S CI + CDG
Sbjct: 185 HNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGR-CIYQNWVCDG 243
Query: 1444 FADCMDFQLDESSC 1457
DC D DE C
Sbjct: 244 EDDCKD-NGDEDGC 256
Score = 75.9 bits (185), Expect = 3e-13
Identities = 42/115 (36%), Positives = 53/115 (46%), Gaps = 10/115 (8%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C ++FSC +C+P + CD DC DGSDE C P C +F C + CI
Sbjct: 183 CLHNEFSC-GNGECIPRAYVCDHDNDCQDGSDEHACNY----PTCGGYQFTCPSGRCIYQ 237
Query: 1398 LLLCDGVPDCHFNEDELICSN-----KSCSNGALVCASSNSCIPAHQRCDGFADC 1447
+CDG DC N DE C + CS C S CI ++ CDG DC
Sbjct: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDC 292
Score = 73.2 bits (178), Expect = 2e-12
Identities = 49/126 (38%), Positives = 58/126 (46%), Gaps = 10/126 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDE---- 1393
C AD+F C +C+P CDG DC D SDE D CS+ EF C D
Sbjct: 2906 CLADEFKCDGG-RCIPSEWICDGDNDCGDMSDE-DKRHQCQNQNCSDSEFLCVNDRPPDR 2963
Query: 1394 -CIPSLLLCDGVPDCHFNEDE-LICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ 1451
CIP +CDG DC DE C+ ++CS C CIP RCD DC D+
Sbjct: 2964 RCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYG-LCIPKIFRCDRHNDCGDYS 3022
Query: 1452 LDESSC 1457
DE C
Sbjct: 3023 -DERGC 3027
Score = 72.8 bits (177), Expect = 2e-12
Identities = 57/166 (34%), Positives = 75/166 (45%), Gaps = 26/166 (15%)
Query: 1303 EADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHE 1362
E DG+ D A D+ +C T P + C+A F C + C+P KCDG +
Sbjct: 3814 ELKCDGSADCLDASDEA----DCPTRFP---DGAYCQATMFECKNHV-CIPPYWKCDGDD 3865
Query: 1363 DCIDGSDE-----MDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDEL--I 1415
DC DGSDE +D P N S F C + CI S +C+GV DC DE
Sbjct: 3866 DCGDGSDEELHLCLDVPCN------SPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEH 3919
Query: 1416 C---SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCS 1458
C + K C+ C + + CIP CD DC D+ DE C+
Sbjct: 3920 CRKPTPKPCTEYEYKCGNGH-CIPHDNVCDDADDCGDWS-DELGCN 3963
Score = 72.0 bits (175), Expect = 4e-12
Identities = 45/133 (33%), Positives = 57/133 (42%), Gaps = 13/133 (9%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C++ C + C+P CDG DC D SDE P T CS+ EF C++ CIP
Sbjct: 2822 CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDEN--PTYCTTHTCSSSEFQCASGRCIPQ 2879
Query: 1398 LLLCDGVPDCHFNEDELIC---SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDF---- 1450
CD DC DE S ++C C CIP+ CDG DC D
Sbjct: 2880 HWYCDQETDCFDASDEPASCGHSERTCLADEFKC-DGGRCIPSEWICDGDNDCGDMSDED 2938
Query: 1451 ---QLDESSCSDT 1460
Q +CSD+
Sbjct: 2939 KRHQCQNQNCSDS 2951
Score = 71.6 bits (174), Expect = 5e-12
Identities = 42/125 (33%), Positives = 56/125 (44%), Gaps = 8/125 (6%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD--CPLNPTPPLCSNMEFPCSTDECI 1395
C A F+C +C+ KCD DC DGSDEM+ C L+ CS F C+ C+
Sbjct: 2700 CGASSFTCSNG-RCISEEWKCDNDNDCGDGSDEMESVCALHT----CSPTAFTCANGRCV 2754
Query: 1396 PSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL-DE 1454
CD DC DE C + C+ ++ CIP C+G +C D DE
Sbjct: 2755 QYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDE 2814
Query: 1455 SSCSD 1459
+C D
Sbjct: 2815 KNCPD 2819
Score = 70.1 bits (170), Expect = 2e-11
Identities = 42/120 (35%), Positives = 50/120 (41%), Gaps = 8/120 (6%)
Query: 1334 QPSPCEADQFSCIYTL----QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC 1389
Q C +F C+ +C+P S CDG DC DG DE N T CS EF C
Sbjct: 2944 QNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQ---NCTRRTCSENEFTC 3000
Query: 1390 STDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
CIP + CD DC DE C ++C C + CI CD DC D
Sbjct: 3001 GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC-QNGRCISKTFVCDEDNDCGD 3059
Score = 68.9 bits (167), Expect = 4e-11
Identities = 52/140 (37%), Positives = 64/140 (45%), Gaps = 11/140 (7%)
Query: 1328 GGPVPVQPSP-CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC-PLNPTPPLCSNM 1385
G P P+ C F C +CVP CDG +DC D SDE C LN T CS+
Sbjct: 1015 GDPTNEPPTEQCGLFSFPC-KNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNT---CSSS 1070
Query: 1386 EFPCSTDECIPSLLLCDGVPDCHFNEDELIC---SNKSCSNGALVCASSNSCIPAHQRCD 1442
F C ECIP+ CD DC DE C + SC + C ++ CI + CD
Sbjct: 1071 AFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC-DNHQCISKNWVCD 1129
Query: 1443 GFADCMDFQLDESSCSDTWT 1462
DC D DE +C+ T T
Sbjct: 1130 TDNDCGDGS-DEKNCNSTET 1148
Score = 63.9 bits (154), Expect = 1e-09
Identities = 36/122 (29%), Positives = 53/122 (43%), Gaps = 11/122 (9%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C+ +QF+C +C+ + CD DC DGSDE+ + P C EF C CI
Sbjct: 3032 CQQNQFTC-QNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEM 3090
Query: 1398 LLLCDGVPDCHFNEDELICSNKSCSNGALVCASSN----------SCIPAHQRCDGFADC 1447
+ LC+ + DC N DE C C + ++ N SC P ++ C
Sbjct: 3091 MKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Query: 1448 MD 1449
+D
Sbjct: 3151 VD 3152
Score = 63.2 bits (152), Expect = 2e-09
Identities = 28/79 (35%), Positives = 37/79 (46%)
Query: 1382 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1441
C + F C + CIP+ CDG DC + DE+ C+ +C G C S CIP C
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVC 87
Query: 1442 DGFADCMDFQLDESSCSDT 1460
D DC D + CS +
Sbjct: 88 DQDQDCDDGSDERQDCSQS 106
Score = 57.0 bits (136), Expect = 1e-07
Identities = 70/285 (24%), Positives = 98/285 (34%), Gaps = 42/285 (14%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSL-CKWYQPI 469
P C +F C SDG+C C+ +CPD SDE + E + C + I
Sbjct: 3549 PQRFCRLGQFQC-SDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCI 3607
Query: 470 PVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQN---TTDGWYLYADSSNGKFGDT- 525
P D+ + S H RP N W D+ G D
Sbjct: 3608 PESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEP 3667
Query: 526 ----------ADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQ 575
D T T +C + W NG V +DN + +
Sbjct: 3668 IEECMSSAHLCDNFTEFSCKTNYRC-IPKWAVCNG-------VDDCRDN--------SDE 3711
Query: 576 QGAQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFM 635
QG + + R + D D+ ++C+P R+CT+ EF
Sbjct: 3712 QGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCG-DNSDEENCAP-----RECTESEFR 3765
Query: 636 CANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS 680
C N+ CI +CD NDC DNSDE RT C E+ C+
Sbjct: 3766 CVNQQCIPSRWICDHYNDCGDNSDERDCEMRT----CHPEYFQCT 3806
Score = 53.9 bits (128), Expect = 1e-06
Identities = 68/275 (24%), Positives = 97/275 (35%), Gaps = 28/275 (10%)
Query: 413 HNCTD-NEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV 471
H C + EF C+++ CI K C+ DC D SDE C C CK + IP+
Sbjct: 3676 HLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPL 3735
Query: 472 HLLQDSNTFRWGLGNGISIHHGEENHRPS--------VDHTQNTTDGWYLYADSSNGKFG 523
D N + EEN P + Q W + G
Sbjct: 3736 RWQCDGQ-------NDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNS 3788
Query: 524 DTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRA 583
D D +CT H GS L D T + +A
Sbjct: 3789 DERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEAD----CPTRFPDGAYCQA 3844
Query: 584 EVFLGIRSHTQIVFRAK-RGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCI 642
+F ++H I K G GD + +++ P SP R F C N CI
Sbjct: 3845 TMF-ECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNR------FRCDNNRCI 3897
Query: 643 AKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFD 677
++C+ V+DC D +DET CR + + E++
Sbjct: 3898 YSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYE 3932
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/105 (34%), Positives = 50/105 (47%), Gaps = 6/105 (5%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP-LCSNMEFPC-STDECI 1395
C QF+C + +C+ + CDG +DC D DE C P CS E+ C + CI
Sbjct: 222 CGGYQFTCP-SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCI 280
Query: 1396 PSLLLCDGVPDCHFNEDELICS-NKSCSNGALVCASSNSCIPAHQ 1439
+CDG+ DC EDE S K CS +C++ N H+
Sbjct: 281 SIYKVCDGILDCPGREDENNTSTGKYCS--MTLCSALNCQYQCHE 323
Score = 53.1 bits (126), Expect = 2e-06
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 18/127 (14%)
Query: 1332 PVQPSPCEADQFSCIYTLQCVPLSGK---CDGHED--CIDGSDEMDCPLNPTPPLCSNME 1386
P+ +PC + C + P GK C+ +D + S C P+CS+ +
Sbjct: 3463 PIVSNPCGTNNGGCSHLCLIKP-GGKGFTCECPDDFRTLQLSGSTYCM-----PMCSSTQ 3516
Query: 1387 FPCSTDE-CIPSLLLCDGVPDCHFNEDEL-ICSNKSCSNGALVCASSNSCIP-----AHQ 1439
F C+ +E CIP CDG DC DEL +C + C G C+ N P AHQ
Sbjct: 3517 FLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQ 3576
Query: 1440 RCDGFAD 1446
C +D
Sbjct: 3577 NCPDGSD 3583
Score = 53.1 bits (126), Expect = 2e-06
Identities = 29/77 (37%), Positives = 38/77 (49%), Gaps = 14/77 (18%)
Query: 622 LLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC----------RTSSGR 671
LL C +E+ CANK CI + CD NDC DNSDE + C R ++GR
Sbjct: 3587 LLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGR 3646
Query: 672 CDFEFDLCSWKQEKDED 688
C + +WK + D D
Sbjct: 3647 CIPQ----AWKCDVDND 3659
Score = 48.9 bits (115), Expect = 4e-05
Identities = 20/37 (54%), Positives = 24/37 (64%)
Query: 624 SPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
+PE C HEF C N CI KLC+ ++DC DNSDE
Sbjct: 3070 TPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDE 3106
Score = 48.1 bits (113), Expect = 6e-05
Identities = 20/58 (34%), Positives = 31/58 (53%), Gaps = 1/58 (1%)
Query: 413 HNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIP 470
H C+ F C ++G C++ +CD+ DC D SDEA C+ C+ +C + IP
Sbjct: 2739 HTCSPTAFTC-ANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIP 2795
Score = 48.1 bits (113), Expect = 6e-05
Identities = 19/44 (43%), Positives = 24/44 (54%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRC 672
C ++F C N CI+K +CD NDC D SDE +C T C
Sbjct: 3032 CQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
Score = 47.0 bits (110), Expect = 1e-04
Identities = 17/34 (50%), Positives = 23/34 (67%)
Query: 627 RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
+ CT++E+ C N HCI D +CD +DC D SDE
Sbjct: 3926 KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDE 3959
Score = 46.6 bits (109), Expect = 2e-04
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 11/80 (13%)
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE------TTFICRTSSG 670
QDCS + C+ H+ C+N CI + CD V DC D +DE T +G
Sbjct: 101 QDCS-----QSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNG 155
Query: 671 RCDFEFDLCSWKQEKDEDFD 690
C C WK + + D
Sbjct: 156 ACYNTSQKCDWKVDCRDSSD 175
Score = 45.4 bits (106), Expect = 4e-04
Identities = 29/89 (32%), Positives = 39/89 (43%), Gaps = 16/89 (17%)
Query: 614 ISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT----------F 663
+ +D S ++ C +EF C N CI + +CD NDC D SDE F
Sbjct: 168 VDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQF 227
Query: 664 ICRTSSGRCDFEFDLC----SWKQEKDED 688
C SGRC ++ +C K DED
Sbjct: 228 TC--PSGRCIYQNWVCDGEDDCKDNGDED 254
Score = 44.7 bits (104), Expect = 7e-04
Identities = 20/48 (41%), Positives = 27/48 (56%), Gaps = 4/48 (8%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----TTFICRTSSGRC 672
C D ++ C N CI+K+ +CD NDC D SDE +T C+ S C
Sbjct: 1109 CLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNC 1156
Score = 44.7 bits (104), Expect = 7e-04
Identities = 18/37 (48%), Positives = 22/37 (59%)
Query: 414 NCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
NCT ++F C S CI +CD +DC D SDEA C
Sbjct: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Score = 44.3 bits (103), Expect = 0.001
Identities = 22/69 (31%), Positives = 33/69 (47%), Gaps = 5/69 (7%)
Query: 627 RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---TTFICRTSSGRCDFEFDLC--SW 681
++C F C + HCI D CD DC+D++DE C+ +C E SW
Sbjct: 26 QECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSW 85
Query: 682 KQEKDEDFD 690
++D+D D
Sbjct: 86 VCDQDQDCD 94
Score = 43.9 bits (102), Expect = 0.001
Identities = 24/72 (33%), Positives = 31/72 (43%), Gaps = 10/72 (13%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS---- 680
P +C F C N C+ LCD V+DC DNSDE +C T + C C
Sbjct: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQ--LCGTLNNTCSSSAFTCGHGEC 1079
Query: 681 ----WKQEKDED 688
W+ +K D
Sbjct: 1080 IPAHWRCDKRND 1091
Score = 43.9 bits (102), Expect = 0.001
Identities = 19/41 (46%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C++NEF C G CI K+ +CD DC D SDE C+ + C
Sbjct: 2993 CSENEFTC-GYGLCIPKIFRCDRHNDCGDYSDERGCLYQTC 3032
Score = 42.7 bits (99), Expect = 0.003
Identities = 24/59 (40%), Positives = 28/59 (47%), Gaps = 11/59 (18%)
Query: 625 PERKCTDHEFMCANKH-CIAKDKLCDFVNDCADNSDETTFICRT----------SSGRC 672
P+R C C N + CI + LCD NDC DNSDE C T +SGRC
Sbjct: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRC 2876
Score = 42.4 bits (98), Expect = 0.004
Identities = 17/46 (36%), Positives = 23/46 (50%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDF 674
C+ F CAN C+ CD+ NDC D SDE + R + +F
Sbjct: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEF 2786
Score = 42.4 bits (98), Expect = 0.004
Identities = 20/57 (35%), Positives = 29/57 (50%), Gaps = 2/57 (3%)
Query: 827 NCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCG 883
+C D + P PT CP +C NG+C + + CN +D+C DN+ E CG
Sbjct: 3056 DCGDGSDELMHLCHTPEPT--CPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCG 3110
Score = 42.0 bits (97), Expect = 0.005
Identities = 21/48 (43%), Positives = 26/48 (54%), Gaps = 1/48 (2%)
Query: 409 TLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVC 455
T PP C +EF C+ DG CI +CD DC SDE +CV + C
Sbjct: 1224 TRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
Score = 41.6 bits (96), Expect = 0.006
Identities = 16/38 (42%), Positives = 22/38 (57%)
Query: 628 KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
+C F C+N CI+++ CD NDC D SDE +C
Sbjct: 2699 RCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVC 2736
Score = 41.6 bits (96), Expect = 0.006
Identities = 21/53 (39%), Positives = 26/53 (49%), Gaps = 1/53 (1%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLC 463
P C +EF C +G CIE M+ C+ DC D SDE C + C S C
Sbjct: 3071 PEPTCPPHEFKC-DNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGC 3122
Score = 41.6 bits (96), Expect = 0.006
Identities = 27/91 (29%), Positives = 38/91 (41%), Gaps = 12/91 (13%)
Query: 169 SAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP-- 226
+ +DD R + +C + F C++ CI CD +DCGD +DE NCAP
Sbjct: 3700 NGVDDCRDNSDEQGCEERTCHPVGDFRCKNHH-CIPLRWQCDGQNDCGDNSDEENCAPRE 3758
Query: 227 ---------ELQCNFETGICNWEQDAKDDFD 248
QC IC+ D D+ D
Sbjct: 3759 CTESEFRCVNQQCIPSRWICDHYNDCGDNSD 3789
Score = 40.8 bits (94), Expect = 0.010
Identities = 34/109 (31%), Positives = 46/109 (42%), Gaps = 22/109 (20%)
Query: 152 PFHLSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDL 211
P H DK + D V D+ NC PA SC LD + CI K +CD
Sbjct: 1081 PAHWRCDKRN----DCVDGSDE---HNCPTHAPA-SC--LDTQYTCDNHQCISKNWVCDT 1130
Query: 212 VDDCGDRTDEVNC------------APELQCNFETGICNWEQDAKDDFD 248
+DCGD +DE NC P +C + +C+ ++D D D
Sbjct: 1131 DNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSD 1179
Score = 40.8 bits (94), Expect = 0.010
Identities = 26/72 (36%), Positives = 34/72 (47%), Gaps = 14/72 (19%)
Query: 627 RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRT--------SSGRCDFEFDL 678
R C+++EF C CI K CD NDC D SDE + +T +GRC + +
Sbjct: 2991 RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
Query: 679 CSWKQEKDEDFD 690
C DED D
Sbjct: 3051 C------DEDND 3056
Score = 40.4 bits (93), Expect = 0.013
Identities = 22/72 (30%), Positives = 35/72 (48%), Gaps = 7/72 (9%)
Query: 617 QDCSP-----LLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGR 671
+DCS L P+R C +F C++ +C + LC+ +C D SDE +C +
Sbjct: 3536 KDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLC--ENHH 3593
Query: 672 CDFEFDLCSWKQ 683
CD C+ K+
Sbjct: 3594 CDSNEWQCANKR 3605
Score = 40.0 bits (92), Expect = 0.017
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C NEF C +G CI + CD DC D SDE +C C
Sbjct: 183 CLHNEFSC-GNGECIPRAYVCDHDNDCQDGSDEHACNYPTC 222
Score = 40.0 bits (92), Expect = 0.017
Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 6/65 (9%)
Query: 1332 PVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD-CPLNPTPPLCSNMEFPCS 1390
P QP C + Q+ C+ CV LS CDG DC +G+DE C N CS+ C
Sbjct: 1306 PTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNS----CSDFNGGC- 1360
Query: 1391 TDECI 1395
T EC+
Sbjct: 1361 THECV 1365
Score = 39.7 bits (91), Expect = 0.023
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C+ ++ C S+G CI +CD DCPD +DE C C
Sbjct: 108 CSSHQITC-SNGQCIPSEYRCDHVRDCPDGADENDCQYPTC 147
Score = 39.7 bits (91), Expect = 0.023
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 6/50 (12%)
Query: 413 HNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEAS------CVMEVCS 456
H C+ E+ C G CI + CD DCP + DE + C M +CS
Sbjct: 264 HKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCS 313
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/94 (27%), Positives = 34/94 (36%), Gaps = 16/94 (17%)
Query: 1098 PPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHY 1157
P E P + L S F C++ +C+ ++ LCD DC SDE C
Sbjct: 1017 PTNEPPTEQCGLFS-------------FPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTL 1063
Query: 1158 TSTTGSCNFETSSGNWTTA---CSLTQDSEDDLD 1188
+T S F G A C D D D
Sbjct: 1064 NNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSD 1097
Score = 39.7 bits (91), Expect = 0.023
Identities = 17/35 (48%), Positives = 19/35 (54%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
ER C EF C CI + +CD NDC D SDE
Sbjct: 2903 ERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Score = 39.3 bits (90), Expect = 0.030
Identities = 20/46 (43%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 627 RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRC 672
+ C F C N +CI + LCD NDC D SDE C T RC
Sbjct: 1269 KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKD--CPTQPFRC 1312
Score = 39.3 bits (90), Expect = 0.030
Identities = 16/40 (40%), Positives = 21/40 (52%)
Query: 185 AESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
A C+ F C+ CI K +C+ VDDC D +DE C
Sbjct: 3675 AHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGC 3714
Score = 38.9 bits (89), Expect = 0.039
Identities = 16/31 (51%), Positives = 20/31 (64%), Gaps = 1/31 (3%)
Query: 425 DGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
+G C QKCD+K DC D SDE +C E+C
Sbjct: 154 NGACYNTSQKCDWKVDCRDSSDEINCT-EIC 183
Score = 38.9 bits (89), Expect = 0.039
Identities = 20/54 (37%), Positives = 27/54 (50%), Gaps = 3/54 (5%)
Query: 844 PTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCG---SSCTFEKGWCG 894
PT C L C NG+C C+ VD+C DN+ E CG ++C+ CG
Sbjct: 1022 PTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCG 1075
Score = 38.9 bits (89), Expect = 0.039
Identities = 21/45 (46%), Positives = 25/45 (55%), Gaps = 2/45 (4%)
Query: 407 PVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASC 450
P H C+ +EF C S G CI + CD + DC D SDE ASC
Sbjct: 2856 PTYCTTHTCSSSEFQCAS-GRCIPQHWYCDQETDCFDASDEPASC 2899
Score = 38.5 bits (88), Expect = 0.051
Identities = 25/82 (30%), Positives = 32/82 (39%), Gaps = 14/82 (17%)
Query: 179 CTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCA------------P 226
C P + C+ HF C CI CD DC D DE+ CA
Sbjct: 19 CLAPASGQECDSA-HFRCGSGH-CIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQS 76
Query: 227 ELQCNFETGICNWEQDAKDDFD 248
E QC + +C+ +QD D D
Sbjct: 77 EGQCIPNSWVCDQDQDCDDGSD 98
Score = 38.5 bits (88), Expect = 0.051
Identities = 18/43 (41%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVCS 456
C F C+S+G CI CD DC D SDE C CS
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCS 109
Score = 38.5 bits (88), Expect = 0.051
Identities = 20/41 (48%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
P E C GL F C++ R C+ LCD VDDC D +DE C
Sbjct: 1022 PTEQC-GLFSFPCKNGR-CVPNYYLCDGVDDCHDNSDEQLC 1060
Score = 38.5 bits (88), Expect = 0.051
Identities = 23/62 (37%), Positives = 30/62 (48%), Gaps = 6/62 (9%)
Query: 414 NCTDNEFICRS----DGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVCSFEKRSLCKWYQP 468
NC+D+EF+C + D CI + CD DC D DE +C CS E C +
Sbjct: 2947 NCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCS-ENEFTCGYGLC 3005
Query: 469 IP 470
IP
Sbjct: 3006 IP 3007
Score = 38.5 bits (88), Expect = 0.051
Identities = 21/74 (28%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFETSSG 1171
C E ++F C +++CI S +CD+ DC SDE C ++ T+G C
Sbjct: 3759 CTE-SEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKC 3817
Query: 1172 NWTTACSLTQDSED 1185
+ + C D D
Sbjct: 3818 DGSADCLDASDEAD 3831
Score = 38.5 bits (88), Expect = 0.051
Identities = 27/113 (23%), Positives = 41/113 (36%), Gaps = 13/113 (11%)
Query: 618 DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-----------R 666
DC C F C N CI CD +DC D SDE +C R
Sbjct: 3831 DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFR 3890
Query: 667 TSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYI 719
+ RC + ++C+ + + D + P +P ++ +GH I
Sbjct: 3891 CDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPT--PKPCTEYEYKCGNGHCI 3941
Score = 38.5 bits (88), Expect = 0.051
Identities = 18/39 (46%), Positives = 21/39 (53%), Gaps = 1/39 (2%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P CT+ E+ C +GHCI CD DC D SDE C
Sbjct: 3925 PKPCTEYEYKC-GNGHCIPHDNVCDDADDCGDWSDELGC 3962
Score = 38.1 bits (87), Expect = 0.066
Identities = 26/84 (30%), Positives = 34/84 (40%), Gaps = 13/84 (15%)
Query: 1113 GEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSC-------- 1164
G ++ C + F C +CI +H CD + DC SDE +C T SC
Sbjct: 1061 GTLNNTCSS-SAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCP--THAPASCLDTQYTCD 1117
Query: 1165 NFETSSGNWTTACSLTQDSEDDLD 1188
N + S NW C D D D
Sbjct: 1118 NHQCISKNW--VCDTDNDCGDGSD 1139
Score = 38.1 bits (87), Expect = 0.066
Identities = 16/45 (35%), Positives = 24/45 (53%)
Query: 1421 CSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSCSDTWTLLG 1465
CS+ +CA++ CIP +CDG DC D + + C + LG
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG 3556
Score = 38.1 bits (87), Expect = 0.066
Identities = 17/42 (40%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVC 455
C+ +F+C ++ CI KCD + DC D SDE A C C
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFC 3553
Score = 37.7 bits (86), Expect = 0.087
Identities = 17/41 (41%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C F C S GHCI +CD DC D +DE C + C
Sbjct: 28 CDSAHFRCGS-GHCIPADWRCDGTKDCSDDADEIGCAVVTC 67
Score = 37.7 bits (86), Expect = 0.087
Identities = 19/43 (44%), Positives = 23/43 (53%), Gaps = 3/43 (6%)
Query: 409 TLPPHNCTDNEFICRSDGH-CIEKMQKCDFKYDCPDKSDEASC 450
T P +C D ++ C D H CI K CD DC D SDE +C
Sbjct: 1103 THAPASCLDTQYTC--DNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Score = 37.7 bits (86), Expect = 0.087
Identities = 37/118 (31%), Positives = 44/118 (37%), Gaps = 24/118 (20%)
Query: 143 TIQLGRLSQPFHLSLDK--VSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTR 200
T Q + + P H +D V G D V D++ C L A F C
Sbjct: 1148 TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEV---GCVLNCTASQ------FKCASGD 1198
Query: 201 ACIEKLRLCDLVDDCGDRTDEVNC---------APELQCNFETGIC---NWEQDAKDD 246
CI CD V DC D +DE C + E QC E GIC WE D D
Sbjct: 1199 KCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQ-EDGICIPNFWECDGHPD 1255
Score = 37.7 bits (86), Expect = 0.087
Identities = 17/43 (39%), Positives = 21/43 (48%)
Query: 618 DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
D +P C+ EF CA+ CI + CD DC D SDE
Sbjct: 2853 DENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDE 2895
Score = 37.7 bits (86), Expect = 0.087
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 1123 TDFLCRDKKCIASHLLCDYKPDCSGRSDE-AHCAHYTSTTGSCNFETSSG 1171
++F C +CI H CD + DC SDE A C H T + F+ G
Sbjct: 2867 SEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGG 2916
Score = 37.7 bits (86), Expect = 0.087
Identities = 15/37 (40%), Positives = 20/37 (54%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
C + DF C++ CI CD + DC SDE +CA
Sbjct: 3719 CHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCA 3755
Score = 37.4 bits (85), Expect = 0.11
Identities = 26/78 (33%), Positives = 34/78 (43%), Gaps = 12/78 (15%)
Query: 1119 CPEI---TDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSG---- 1171
C EI +F C + +CI +CD+ DC SDE C + T G F SG
Sbjct: 179 CTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNY--PTCGGYQFTCPSGRCIY 236
Query: 1172 -NWTTACSLTQDSEDDLD 1188
NW C D +D+ D
Sbjct: 237 QNW--VCDGEDDCKDNGD 252
Score = 37.4 bits (85), Expect = 0.11
Identities = 19/44 (43%), Positives = 24/44 (54%), Gaps = 3/44 (6%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCS 456
C + F C S+G CI + KCD DC D SD E+ C + CS
Sbjct: 2700 CGASSFTC-SNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCS 2742
Score = 37.0 bits (84), Expect = 0.15
Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 8/67 (11%)
Query: 1127 CRDKKCIASHLLCDYKPDCSGRSDEAHCAH-----YTSTTGSCNFETSSGNWTTACSLTQ 1181
C + +CI S CD+ DC +DE C + T G+C + +W C +
Sbjct: 115 CSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDC---R 171
Query: 1182 DSEDDLD 1188
DS D+++
Sbjct: 172 DSSDEIN 178
Score = 37.0 bits (84), Expect = 0.15
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCG 894
C NG CY Q C++ +C D++ E C C + CG
Sbjct: 152 CDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCG 191
Score = 37.0 bits (84), Expect = 0.15
Identities = 26/83 (31%), Positives = 35/83 (42%), Gaps = 16/83 (19%)
Query: 837 EELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENK-------CGSS---- 885
+ELA+ P FC LG +C +G C + CN NC D + E++ C S+
Sbjct: 3543 DELAL-CPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQC 3601
Query: 886 ----CTFEKGWCGWQNSQADNFD 904
C E C N DN D
Sbjct: 3602 ANKRCIPESWQCDTFNDCEDNSD 3624
Score = 36.6 bits (83), Expect = 0.19
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 11/58 (18%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC-----------APELQCNFETGICNWEQDAKDDFD 248
CI + +CD +DC D +DE C P +C ++ +C+ E D KD+ D
Sbjct: 195 CIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGD 252
Score = 36.6 bits (83), Expect = 0.19
Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 2/46 (4%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI--CRTSSGRC 672
C +F C N CI +CD DC D SDE + C S +C
Sbjct: 1149 CQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKC 1194
Score = 36.6 bits (83), Expect = 0.19
Identities = 24/78 (30%), Positives = 28/78 (35%), Gaps = 3/78 (3%)
Query: 404 TSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE--ASCVMEVCSFEKRS 461
TS P C C + CI ++ CD DC D SDE C CS
Sbjct: 2811 TSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCS-SSEF 2869
Query: 462 LCKWYQPIPVHLLQDSNT 479
C + IP H D T
Sbjct: 2870 QCASGRCIPQHWYCDQET 2887
Score = 36.2 bits (82), Expect = 0.25
Identities = 17/33 (51%), Positives = 20/33 (60%), Gaps = 1/33 (3%)
Query: 629 CTDHEFMCAN-KHCIAKDKLCDFVNDCADNSDE 660
CT +F CA+ CI CD V DC+DNSDE
Sbjct: 1187 CTASQFKCASGDKCIGVTNRCDGVFDCSDNSDE 1219
Score = 35.8 bits (81), Expect = 0.33
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
P C + F C +G+CI + CD DC D SDE C
Sbjct: 1268 PKTCPSSYFHC-DNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 35.8 bits (81), Expect = 0.33
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Query: 633 EFMCANKHCIAKDKLCDFVNDCADN--SDETTFICRT 667
EFMC N+ CI ++ +C+ V++C DN SDE RT
Sbjct: 2785 EFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT 2821
Score = 35.8 bits (81), Expect = 0.33
Identities = 19/60 (31%), Positives = 28/60 (46%), Gaps = 7/60 (11%)
Query: 627 RKCTDHEFMCAN-----KHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE--FDLC 679
+ C+D EF+C N + CI + +CD DC D DE R + +F + LC
Sbjct: 2946 QNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLC 3005
Score = 35.8 bits (81), Expect = 0.33
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 4/41 (9%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C N+F C++ G CI K CD DC D SDE +M +C
Sbjct: 3032 CQQNQFTCQN-GRCISKTFVCDEDNDCGDGSDE---LMHLC 3068
Score = 35.8 bits (81), Expect = 0.33
Identities = 26/74 (35%), Positives = 31/74 (41%), Gaps = 14/74 (18%)
Query: 629 CTDHEFMCANKH-CIAKDKLCDFVNDCADNSDETTF----ICR-----TSSGRCDFEFDL 678
C+ +F+CAN CI CD DC+D SDE CR S G C L
Sbjct: 3512 CSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTL 3571
Query: 679 CSWKQE----KDED 688
C+ Q DED
Sbjct: 3572 CNAHQNCPDGSDED 3585
Score = 35.4 bits (80), Expect = 0.43
Identities = 22/66 (33%), Positives = 26/66 (39%), Gaps = 2/66 (3%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTG--SCNFETSSGNWTTACSLTQD 1182
F C CI + CD DCS +DE CA T G C E + C QD
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQD 92
Query: 1183 SEDDLD 1188
+D D
Sbjct: 93 CDDGSD 98
Score = 35.4 bits (80), Expect = 0.43
Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 17/92 (18%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-------- 228
+NCT +E+ F C + CI K+ CD +DCGD +DE C +
Sbjct: 2986 QNCTRRTCSEN-----EFTCGYG-LCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTC 3039
Query: 229 ---QCNFETGICNWEQDAKDDFDWTRNQGPTP 257
+C +T +C+ + D D D + TP
Sbjct: 3040 QNGRCISKTFVCDEDNDCGDGSDELMHLCHTP 3071
Score = 35.4 bits (80), Expect = 0.43
Identities = 27/80 (33%), Positives = 34/80 (42%), Gaps = 14/80 (17%)
Query: 188 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV--NC-------APELQCNFETGIC- 237
C + F C + R CI +C+ VDDCGD TDE +C E + G C
Sbjct: 3883 CNSPNRFRCDNNR-CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCI 3941
Query: 238 ---NWEQDAKDDFDWTRNQG 254
N DA D DW+ G
Sbjct: 3942 PHDNVCDDADDCGDWSDELG 3961
Score = 35.4 bits (80), Expect = 0.43
Identities = 20/75 (26%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEA--HCAHYT-STTGSCNFETSSGNWTT 1175
C F C + +CI SH +C+ DC +DE HC T ++ +G+
Sbjct: 3883 CNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIP 3942
Query: 1176 ACSLTQDSEDDLDWA 1190
++ D++D DW+
Sbjct: 3943 HDNVCDDADDCGDWS 3957
Score = 35.0 bits (79), Expect = 0.56
Identities = 15/38 (39%), Positives = 21/38 (55%), Gaps = 1/38 (2%)
Query: 413 HNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
+ C+ + F C G CI +CD + DC D SDE +C
Sbjct: 1065 NTCSSSAFTC-GHGECIPAHWRCDKRNDCVDGSDEHNC 1101
Score = 34.7 bits (78), Expect = 0.73
Identities = 17/52 (32%), Positives = 23/52 (44%), Gaps = 3/52 (5%)
Query: 831 LHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKC 882
L+ S + VP CP Y C NG C C+ ++CGD + E C
Sbjct: 1257 LYGSDEHNACVPKT---CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 34.7 bits (78), Expect = 0.73
Identities = 14/32 (43%), Positives = 17/32 (53%)
Query: 1123 TDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
T F C + +C+ CDY DC SDEA C
Sbjct: 2744 TAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 34.7 bits (78), Expect = 0.73
Identities = 14/46 (30%), Positives = 25/46 (54%), Gaps = 2/46 (4%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDC--SGRSDEAHCAHYTSTTG 1162
C T+F+C +++CI +C+ +C + SDE +C T +G
Sbjct: 2780 CNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSG 2825
Score = 34.7 bits (78), Expect = 0.73
Identities = 23/80 (28%), Positives = 36/80 (45%), Gaps = 20/80 (25%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDE--------VNCA-----------PELQCNF 232
D F C R CI +CD +DCGD +DE NC+ P+ +C
Sbjct: 2909 DEFKCDGGR-CIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIP 2967
Query: 233 ETGICNWEQDAKDDFDWTRN 252
++ +C+ + D D +D +N
Sbjct: 2968 QSWVCDGDVDCTDGYDENQN 2987
Score = 34.7 bits (78), Expect = 0.73
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 3/59 (5%)
Query: 849 PLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCG-SSCTFEKGWCGWQNSQADNFDWV 906
P+G C N C L C+ ++CGDN+ E C CT + C N Q W+
Sbjct: 3721 PVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRC--VNQQCIPSRWI 3777
Score = 34.3 bits (77), Expect = 0.96
Identities = 14/32 (43%), Positives = 16/32 (50%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C+ F C + CI CD NDC D SDE
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDE 1098
Score = 34.3 bits (77), Expect = 0.96
Identities = 16/45 (35%), Positives = 26/45 (57%), Gaps = 5/45 (11%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDE 221
+NC P +C+ + C ++ CI ++ LCD +DCGD +DE
Sbjct: 2815 KNC----PDRTCQS-GYTKCHNSNICIPRVYLCDGDNDCGDNSDE 2854
Score = 34.3 bits (77), Expect = 0.96
Identities = 15/31 (48%), Positives = 21/31 (67%), Gaps = 1/31 (3%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
F C + R CIE ++LC+ +DDC D +DE C
Sbjct: 3080 FKCDNGR-CIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 34.3 bits (77), Expect = 0.96
Identities = 24/79 (30%), Positives = 34/79 (43%), Gaps = 4/79 (5%)
Query: 159 KVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDR 218
+V G+ D D+ E+C P P E + C + CI +CD DDCGD
Sbjct: 3901 EVCNGVDDCGDGTDETE-EHCRKPTPKPCTEY--EYKCGNGH-CIPHDNVCDDADDCGDW 3956
Query: 219 TDEVNCAPELQCNFETGIC 237
+DE+ C + IC
Sbjct: 3957 SDELGCNKGKERTCAENIC 3975
Score = 33.9 bits (76), Expect = 1.3
Identities = 20/72 (27%), Positives = 31/72 (43%), Gaps = 18/72 (25%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTD-----------------EVNCAPELQCNFETGI 236
F C + R CI + CD+ +DCGD +D E +C +C + +
Sbjct: 3640 FRCANGR-CIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAV 3698
Query: 237 CNWEQDAKDDFD 248
CN D +D+ D
Sbjct: 3699 CNGVDDCRDNSD 3710
Score = 33.5 bits (75), Expect = 1.6
Identities = 12/32 (37%), Positives = 19/32 (59%)
Query: 1123 TDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
T + C + +CI+ + +CD DC SDE +C
Sbjct: 1112 TQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC 1143
Score = 33.5 bits (75), Expect = 1.6
Identities = 24/84 (28%), Positives = 32/84 (38%), Gaps = 13/84 (15%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNC-------APELQCNF-----ETGICNWEQ 241
F C + R C++ CD +DCGD +DE C E CN ICN
Sbjct: 2746 FTCANGR-CVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVD 2804
Query: 242 DAKDDFDWTRNQGPTPTLNTGPMK 265
+ D+ P T +G K
Sbjct: 2805 NCHDNNTSDEKNCPDRTCQSGYTK 2828
Score = 33.5 bits (75), Expect = 1.6
Identities = 18/45 (40%), Positives = 23/45 (51%), Gaps = 1/45 (2%)
Query: 855 CHNGKCYRLEQSCNFVDNCGD-NTGENKCGSSCTFEKGWCGWQNS 898
C+N +C E CN VDNC D NT + K T + G+ NS
Sbjct: 2788 CNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNS 2832
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 844 PTGFCPLGYRECHNGK-CYRLEQSCNFVDNCGDNTGEN 880
P C GY +CHN C C+ ++CGDN+ EN
Sbjct: 2818 PDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDEN 2855
Score = 33.5 bits (75), Expect = 1.6
Identities = 17/49 (34%), Positives = 22/49 (44%)
Query: 833 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENK 881
D EEL + L C N +C + CN VD+CGD T E +
Sbjct: 3869 DGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETE 3917
Score = 33.1 bits (74), Expect = 2.1
Identities = 22/78 (28%), Positives = 33/78 (42%), Gaps = 3/78 (3%)
Query: 1113 GEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDE-AHCAHYTS-TTGSCNFETSS 1170
G + + C + F C++ +CI+ +CD DC SDE H H T F+ +
Sbjct: 3026 GCLYQTCQQ-NQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDN 3084
Query: 1171 GNWTTACSLTQDSEDDLD 1188
G L +D LD
Sbjct: 3085 GRCIEMMKLCNHLDDCLD 3102
Score = 33.1 bits (74), Expect = 2.1
Identities = 15/44 (34%), Positives = 21/44 (47%), Gaps = 1/44 (2%)
Query: 1116 SELCPEITDFLCRDK-KCIASHLLCDYKPDCSGRSDEAHCAHYT 1158
+ LC T+F C+ +CI +C+ DC SDE C T
Sbjct: 3675 AHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERT 3718
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/54 (35%), Positives = 23/54 (42%), Gaps = 1/54 (1%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQP 468
C +F C S G CI + CD + DC D DE C K S +W P
Sbjct: 222 CGGYQFTCPS-GRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCP 274
Score = 32.7 bits (73), Expect = 2.8
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 14/75 (18%)
Query: 826 ENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGD-------NTG 878
++C D +E P P Y+ C NG C + C+ D+CGD N G
Sbjct: 3907 DDCGDGTDETEEHCRKPTPKPCTEYEYK-CGNGHCIPHDNVCDDADDCGDWSDELGCNKG 3965
Query: 879 ------ENKCGSSCT 887
EN C +CT
Sbjct: 3966 KERTCAENICEQNCT 3980
Score = 32.3 bits (72), Expect = 3.6
Identities = 17/61 (27%), Positives = 23/61 (37%), Gaps = 11/61 (18%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKC-----------GSSCTFEKGWCGWQNSQADNF 903
C NG+C E C+ V +C D EN C +C C W+ D+
Sbjct: 115 CSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSS 174
Query: 904 D 904
D
Sbjct: 175 D 175
Score = 32.3 bits (72), Expect = 3.6
Identities = 21/64 (32%), Positives = 26/64 (40%), Gaps = 4/64 (6%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC--VMEVCSFEKRSLCKWYQP 468
P C F C++ G C+ CD DC D SDE C + CS C +
Sbjct: 1022 PTEQCGLFSFPCKN-GRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCS-SSAFTCGHGEC 1079
Query: 469 IPVH 472
IP H
Sbjct: 1080 IPAH 1083
Score = 32.3 bits (72), Expect = 3.6
Identities = 22/76 (28%), Positives = 32/76 (42%), Gaps = 2/76 (2%)
Query: 1116 SELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA-HYTSTTGSCNFETSSGNWT 1174
+E C + + F C + +CI +CD DC SDE C + T++ C T
Sbjct: 1146 TETC-QPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT 1204
Query: 1175 TACSLTQDSEDDLDWA 1190
C D D+ D A
Sbjct: 1205 NRCDGVFDCSDNSDEA 1220
Score = 32.3 bits (72), Expect = 3.6
Identities = 12/23 (52%), Positives = 16/23 (69%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC 224
CI + LCD +DCGD +DE +C
Sbjct: 1283 CIHRAWLCDRDNDCGDMSDEKDC 1305
Score = 32.3 bits (72), Expect = 3.6
Identities = 10/28 (35%), Positives = 17/28 (60%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKC 882
C NG+C + C++ ++CGD + E C
Sbjct: 2748 CANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 32.3 bits (72), Expect = 3.6
Identities = 18/47 (38%), Positives = 24/47 (51%), Gaps = 6/47 (12%)
Query: 1114 EISELC--PEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
E+ LC PE T +F C + +CI LC++ DC SDE C
Sbjct: 3063 ELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGC 3109
Score = 32.3 bits (72), Expect = 3.6
Identities = 19/48 (39%), Positives = 25/48 (52%), Gaps = 6/48 (12%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
ENC P E E F C + + CI +CD +DCGD +DE +C
Sbjct: 3752 ENCA---PRECTES--EFRCVNQQ-CIPSRWICDHYNDCGDNSDERDC 3793
Score = 32.3 bits (72), Expect = 3.6
Identities = 23/79 (29%), Positives = 32/79 (40%), Gaps = 15/79 (18%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTD-EVNCAPELQCN-------------FETGICNW 239
F C++ CI CD DDCGD +D E++ ++ CN + +CN
Sbjct: 3847 FECKN-HVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNG 3905
Query: 240 EQDAKDDFDWTRNQGPTPT 258
D D D T PT
Sbjct: 3906 VDDCGDGTDETEEHCRKPT 3924
Score = 32.0 bits (71), Expect = 4.8
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVM 452
C ++F C + CI+ CD DC D SDE CV+
Sbjct: 1149 CQPSQFNCPNH-RCIDLSFVCDGDKDCVDGSDEVGCVL 1185
Score = 32.0 bits (71), Expect = 4.8
Identities = 23/90 (25%), Positives = 34/90 (37%), Gaps = 7/90 (7%)
Query: 1104 NRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGS 1163
NR+ ++ GE + F C + +CI+ CD DC SDE T
Sbjct: 2688 NRKHCIVDNGERCGA----SSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSP 2743
Query: 1164 CNFETSSG---NWTTACSLTQDSEDDLDWA 1190
F ++G ++ C D D D A
Sbjct: 2744 TAFTCANGRCVQYSYRCDYYNDCGDGSDEA 2773
Score = 31.2 bits (69), Expect = 8.1
Identities = 19/56 (33%), Positives = 26/56 (46%), Gaps = 9/56 (16%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC----APELQCN----FETG-ICNWEQDAKDDFD 248
CI CD V DC D DE +C +L C+ + T C+W+ D +D D
Sbjct: 120 CIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSD 175
Score = 31.2 bits (69), Expect = 8.1
Identities = 18/58 (31%), Positives = 25/58 (43%), Gaps = 10/58 (17%)
Query: 201 ACIEKLRLCDLVDDCGDRTDEVNCAPE-LQCNFETG---------ICNWEQDAKDDFD 248
AC + CD DC D +DE+NC L F G +C+ + D +D D
Sbjct: 156 ACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSD 213
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 92.4 bits (228), Expect = 3e-18
Identities = 49/128 (38%), Positives = 65/128 (50%), Gaps = 10/128 (7%)
Query: 1334 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1392
+P C DQF+C + C+P + +CDG +C D SDE CP+ CS +FPC+
Sbjct: 1255 EPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV------CSAAQFPCARG 1308
Query: 1393 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
+C+ L CDG DC DE C + C CA S C+ Q+CD F DC+D
Sbjct: 1309 QCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFRCA-SGQCVLIKQQCDSFPDCIDGS- 1365
Query: 1453 DESSCSDT 1460
DE C T
Sbjct: 1366 DELMCEIT 1373
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 10/91 (10%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTP----PLCSNMEFPCSTDE 1393
C +QF C + QCV + +CD DCIDGSDE+ C + P P S+ P
Sbjct: 1336 CLPNQFRCA-SGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGP--VIG 1392
Query: 1394 CIPSLLLCDGVPDCHFNEDELICSNKSCSNG 1424
I SL + GV +F ++C + +NG
Sbjct: 1393 IILSLFVMGGV---YFVCQRVVCQRYAGANG 1420
Score = 37.4 bits (85), Expect = 0.11
Identities = 15/36 (41%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
C+ +F C + G C++ +CD + DC D+SDEA C
Sbjct: 1298 CSAAQFPC-ARGQCVDLRLRCDGEADCQDRSDEADC 1332
Score = 35.4 bits (80), Expect = 0.43
Identities = 24/87 (27%), Positives = 33/87 (37%), Gaps = 17/87 (19%)
Query: 1117 ELCP--EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC------AHYTSTTGSCNF-- 1166
E CP F C +C+ L CD + DC RSDEA C + +G C
Sbjct: 1293 EGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIK 1352
Query: 1167 -------ETSSGNWTTACSLTQDSEDD 1186
+ G+ C +T+ DD
Sbjct: 1353 QQCDSFPDCIDGSDELMCEITKPPSDD 1379
Score = 35.4 bits (80), Expect = 0.43
Identities = 16/44 (36%), Positives = 22/44 (50%)
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
QD S + C ++F CA+ C+ + CD DC D SDE
Sbjct: 1324 QDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDE 1367
Score = 35.4 bits (80), Expect = 0.43
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
C N+F C S G C+ Q+CD DC D SDE C
Sbjct: 1336 CLPNQFRCAS-GQCVLIKQQCDSFPDCIDGSDELMC 1370
Score = 34.3 bits (77), Expect = 0.96
Identities = 35/154 (22%), Positives = 60/154 (38%), Gaps = 27/154 (17%)
Query: 314 MFGKRIYRLAIYQRIWSDSRGQLLWQIFGNQGNRWIRKHLNISSRQPFQILVEASVGDGF 373
+ GK +Y W D + Q++ ++ G++ R ++ + E S+ +
Sbjct: 1162 ILGKHLY--------WIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFS 1213
Query: 374 TGDIAIDDLSFMDCTLYPGNLPADLPTPPETSVPVTL----------PPHNCTDNEFICR 423
A D+ + G+ P S PV L P C+ ++F C
Sbjct: 1214 AHPCARDNGGCSHICIAKGD------GTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACA 1267
Query: 424 S-DGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
+ + CI +CD +C D+SDE C VCS
Sbjct: 1268 TGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCS 1299
Score = 34.3 bits (77), Expect = 0.96
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 16/121 (13%)
Query: 612 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET--TFIC---- 665
DD S ++ P+ C+ +F CA C+ CD DC D SDE IC
Sbjct: 1287 DDQSDEEGCPV------CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQ 1340
Query: 666 -RTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSL 724
R +SG+C C + + D + + P + PA +G G I SL
Sbjct: 1341 FRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIG---IILSL 1397
Query: 725 F 725
F
Sbjct: 1398 F 1398
Score = 31.2 bits (69), Expect = 8.1
Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 10/91 (10%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSC-----TFEKGWCGWQNSQADN 902
C C G+C L C+ +C D + E C + C G C Q D+
Sbjct: 1298 CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDS 1357
Query: 903 FDWVLGVGSHQSL----RPPKDHTLGNENAI 929
F + GS + + +PP D + + +AI
Sbjct: 1358 FPDCID-GSDELMCEITKPPSDDSPAHSSAI 1387
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 92.4 bits (228), Expect = 3e-18
Identities = 55/142 (38%), Positives = 69/142 (48%), Gaps = 15/142 (10%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPL--------NPTP-PLCSNM 1385
PS C + + C + CV + CDG+ DC DGSDE CPL PT C
Sbjct: 1416 PSTCLPNYYRCS-SGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRF 1474
Query: 1386 EFPCSTDE-CIPSLLLCDGVPDCHFNEDELIC---SNKSCSNGALVCASSNSCIPAHQRC 1441
EF C + CIP+ CDG DC DE C S +C + C +CI +RC
Sbjct: 1475 EFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERC 1534
Query: 1442 DGFADCMDFQLDESSCSDTWTL 1463
DGF DC D + DE +CSD T+
Sbjct: 1535 DGFLDCSD-ESDEKACSDELTV 1555
Score = 80.9 bits (198), Expect = 9e-15
Identities = 48/122 (39%), Positives = 58/122 (47%), Gaps = 22/122 (18%)
Query: 1338 CEAD-QFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C+ D QF C + C+PLS KCD +DC D SDE C ++ C + E+ CS+ CI
Sbjct: 1117 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ----CRSDEYNCSSGMCIR 1172
Query: 1397 SLLLCDGVPDCHFNEDELIC---------SNKSCSNGALVCASSNSCIPAHQRCDGFADC 1447
S +CDG DC DE C SN C NG CIP CDG DC
Sbjct: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG--------HCIPQRWACDGDTDC 1224
Query: 1448 MD 1449
D
Sbjct: 1225 QD 1226
Score = 75.5 bits (184), Expect = 4e-13
Identities = 38/95 (40%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 1326 VTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNM 1385
VT P Q C+ +F C C+P +CDGH+DC DG DE +CP + T C +
Sbjct: 1459 VTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHST-LTCMSR 1517
Query: 1386 EFPCSTDE-CIPSLLLCDGVPDCHFNEDELICSNK 1419
EF C E CI CDG DC DE CS++
Sbjct: 1518 EFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
Score = 70.1 bits (170), Expect = 2e-11
Identities = 48/132 (36%), Positives = 61/132 (46%), Gaps = 15/132 (11%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPT-PPLCSN-MEFPCSTDECI 1395
C+ F C + C+ L KCDG +DC D SDE +C NPT P CS +F C CI
Sbjct: 1325 CDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCE-NPTEAPNCSRYFQFRCENGHCI 1382
Query: 1396 PSLLLCDGVPDCHFNEDELICSNKS----CSNGALVC------ASSNSCIPAHQRCDGFA 1445
P+ CD DC DE C + + G C SS +C+ CDG+
Sbjct: 1383 PNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYR 1442
Query: 1446 DCMDFQLDESSC 1457
DC D DE +C
Sbjct: 1443 DCADGS-DEEAC 1453
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 48/112 (42%), Gaps = 6/112 (5%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
CEA F C C+P CDG DC DGSDE P+N C+ F C CIPS
Sbjct: 1199 CEASNFQC-RNGHCIPQRWACDGDTDCQDGSDED--PVN-CEKKCNG--FRCPNGTCIPS 1252
Query: 1398 LLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
CDG+ DC DE C VC + C+ CDG C D
Sbjct: 1253 SKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRD 1304
Score = 68.9 bits (167), Expect = 4e-11
Identities = 45/130 (34%), Positives = 55/130 (42%), Gaps = 10/130 (7%)
Query: 1343 FSCIYTLQCVPLSGKCDGHEDCIDGSDE----MDCPLNPT-PPLCSNMEFPCSTDECIPS 1397
F C QC+ S CDG C DGSDE C +P +C F C CI
Sbjct: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISL 1340
Query: 1398 LLLCDGVPDCHFNEDELICSN----KSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
+ CDG+ DC DE C N +CS + CIP +CD DC D+ D
Sbjct: 1341 IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWS-D 1399
Query: 1454 ESSCSDTWTL 1463
E C D+ L
Sbjct: 1400 EKDCGDSHIL 1409
Score = 65.1 bits (157), Expect = 5e-10
Identities = 43/127 (33%), Positives = 59/127 (46%), Gaps = 9/127 (7%)
Query: 1334 QPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCS-NMEFPC-ST 1391
+ + C +Q+ C C+ CD DC D SDE +CP +C + +F C +
Sbjct: 1074 EENTCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDERNCPTT----ICDLDTQFRCQES 1128
Query: 1392 DECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQ 1451
CIP CD DC N DE C C + C SS CI + CDG DC D+
Sbjct: 1129 GTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNC-SSGMCIRSSWVCDGDNDCRDWS 1187
Query: 1452 LDESSCS 1458
DE++C+
Sbjct: 1188 -DEANCT 1193
Score = 51.2 bits (121), Expect = 8e-06
Identities = 65/284 (22%), Positives = 105/284 (36%), Gaps = 44/284 (15%)
Query: 392 GNLPADLPTPPETSVPVTLPPHN-CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
G+L D P + + N C N++ C S+G+CI + CDF DC D SDE +C
Sbjct: 1054 GDLMCDCPQGYQLKNNTCVKEENTCLRNQYRC-SNGNCINSIWWCDFDNDCGDMSDERNC 1112
Query: 451 VMEVCSFEKRSLCKWYQP-IPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNT-- 507
+C + + C+ IP+ D G+ H E + S ++ ++
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLED---DCGDNSDESHCEMHQCRSDEYNCSSGM 1169
Query: 508 --TDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNV 565
W D+ + D A+ CT ++ T + Q + +
Sbjct: 1170 CIRSSWVCDGDNDCRDWSDEAN------------CTAIYHT----CEASNFQ--CRNGHC 1211
Query: 566 TSKLWAQTGQQGAQWKRAEVFL-------GIRSHTQIVFRAKRGISYIGDVAVDDISFQD 618
+ WA G Q E + G R + + + D + D Q
Sbjct: 1212 IPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCS-DGSDEQH 1270
Query: 619 CSPLLSPERKCTDH-EFMCANK-HCIAKDKLCDFVNDCADNSDE 660
C PL CT +F+C N+ C+ +CD + C D SDE
Sbjct: 1271 CEPL------CTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
Score = 45.8 bits (107), Expect = 3e-04
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 10/87 (11%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC-----NFETGIC- 237
P C+ F C+ + CI CDL DDCGD +DE +C QC N +G+C
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMH-QCRSDEYNCSSGMCI 1171
Query: 238 --NWEQDAKDDF-DWTRNQGPTPTLNT 261
+W D +D DW+ T +T
Sbjct: 1172 RSSWVCDGDNDCRDWSDEANCTAIYHT 1198
Score = 45.8 bits (107), Expect = 3e-04
Identities = 32/105 (30%), Positives = 42/105 (40%), Gaps = 20/105 (19%)
Query: 602 GISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET 661
GI D + +D +F CS + C + F C N CI+ CD ++DC D SDE
Sbjct: 1298 GIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
Query: 662 T-------------FICRTSSG-------RCDFEFDLCSWKQEKD 686
F R +G +CD E D W EKD
Sbjct: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKD 1402
Score = 44.3 bits (103), Expect = 0.001
Identities = 67/283 (23%), Positives = 95/283 (33%), Gaps = 76/283 (26%)
Query: 1114 EISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSC---NFETSS 1170
E ++C E F C++ CI+ CD DC SDEA+C + T F +
Sbjct: 1320 EFHKVCDEF-GFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN 1378
Query: 1171 GNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGS-------- 1222
G+ D DW+ ++P S P + Y SSG+
Sbjct: 1379 GHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVC 1438
Query: 1223 ------KEGS------VARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGL 1270
+GS + T+ S P LG C RF F P++
Sbjct: 1439 DGYRDCADGSDEEACPLLANVTAASTPTQLGRCD-RFEFECHQPKTC------------- 1484
Query: 1271 NILVWSVIGNKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGP 1330
I W KR DG++D D+ + C T
Sbjct: 1485 -IPNW-----KR-----------------------CDGHQDCQDGRDEAN----CPTHST 1511
Query: 1331 VPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC 1373
+ C + +F C C+ LS +CDG DC D SDE C
Sbjct: 1512 L-----TCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
Score = 43.5 bits (101), Expect = 0.002
Identities = 31/99 (31%), Positives = 40/99 (40%), Gaps = 15/99 (15%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGN-----WTTACS 1178
++ C CI S +CD DC SDEA+C T + NF+ +G+ W AC
Sbjct: 1162 EYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW--ACD 1219
Query: 1179 LTQDSEDDLD--------WAIGSRIPAKALIPDSDHTPG 1209
D +D D G R P IP S H G
Sbjct: 1220 GDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDG 1258
Score = 42.4 bits (98), Expect = 0.004
Identities = 25/69 (36%), Positives = 32/69 (46%), Gaps = 17/69 (24%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE-----------TTFICRTS------ 668
E C +++ C+N +CI CDF NDC D SDE T F C+ S
Sbjct: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPL 1134
Query: 669 SGRCDFEFD 677
S +CD E D
Sbjct: 1135 SYKCDLEDD 1143
Score = 40.0 bits (92), Expect = 0.017
Identities = 19/55 (34%), Positives = 29/55 (52%), Gaps = 3/55 (5%)
Query: 411 PPHN---CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSL 462
P H+ C EF C CI ++CD DC D+SDE +C E+ ++ ++L
Sbjct: 1507 PTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNL 1561
Score = 39.3 bits (90), Expect = 0.030
Identities = 36/114 (31%), Positives = 48/114 (42%), Gaps = 15/114 (13%)
Query: 618 DCSPLLSPERKCT------DHEFMCANKH-CIAKDKLCDFVNDCADNSDET---TFICRT 667
DC + S ER C D +F C CI CD +DC DNSDE+ CR+
Sbjct: 1102 DCGDM-SDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRS 1160
Query: 668 SSGRCDFEFDL-CSWKQEKDEDF-DWNLKASSIPAAGTEPAADHTLGNSSGHYI 719
C + SW + D D DW+ +A+ T A++ N GH I
Sbjct: 1161 DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN--GHCI 1212
Score = 38.9 bits (89), Expect = 0.039
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 16/83 (19%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE------ 660
GD D S +D ++ E+KC F C N CI K CD + DC+D SDE
Sbjct: 1220 GDTDCQDGSDEDP---VNCEKKCNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPL 1274
Query: 661 ----TTFICRTSSGRCDFEFDLC 679
F+C+ +C F +C
Sbjct: 1275 CTHFMDFVCKNRQ-QCLFHSMVC 1296
Score = 38.9 bits (89), Expect = 0.039
Identities = 26/70 (37%), Positives = 35/70 (50%), Gaps = 14/70 (20%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNC-----APE----LQCNFETGIC---NWEQ 241
F C++ CI + CD +DDCGD +DE NC AP Q E G C W+
Sbjct: 1330 FQCQNG-VCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKC 1388
Query: 242 DAKDDF-DWT 250
D ++D DW+
Sbjct: 1389 DRENDCGDWS 1398
Score = 38.5 bits (88), Expect = 0.051
Identities = 22/74 (29%), Positives = 32/74 (43%), Gaps = 3/74 (4%)
Query: 1118 LCPEITDFLCRDK-KCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA 1176
+C T F C++ CI CD + DC SDE+HC + S + SSG +
Sbjct: 1116 ICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCR--SDEYNCSSGMCIRS 1173
Query: 1177 CSLTQDSEDDLDWA 1190
+ D DW+
Sbjct: 1174 SWVCDGDNDCRDWS 1187
Score = 38.1 bits (87), Expect = 0.066
Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 2/70 (2%)
Query: 166 DGVSAIDDIRFE-NCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
DG+ D E NC P A +C F C + CI CD +DCGD +DE +C
Sbjct: 1345 DGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGH-CIPNRWKCDRENDCGDWSDEKDC 1403
Query: 225 APELQCNFET 234
F T
Sbjct: 1404 GDSHILPFST 1413
Score = 38.1 bits (87), Expect = 0.066
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 10/59 (16%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---------TTFICRTSSGRCD-FEFD 677
C + + C++ C+ +CD DCAD SDE T T GRCD FEF+
Sbjct: 1419 CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
Score = 37.4 bits (85), Expect = 0.11
Identities = 16/37 (43%), Positives = 17/37 (45%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
C F C N HCI + CD DC D SDE C
Sbjct: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC 1235
Score = 35.8 bits (81), Expect = 0.33
Identities = 20/55 (36%), Positives = 29/55 (52%), Gaps = 11/55 (20%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNCAPELQCNFET-------GIC---NWEQDAKDD 246
CI + CD +DCGD +DE NC P C+ +T G C +++ D +DD
Sbjct: 1090 CINSIWWCDFDNDCGDMSDERNC-PTTICDLDTQFRCQESGTCIPLSYKCDLEDD 1143
Score = 35.8 bits (81), Expect = 0.33
Identities = 70/314 (22%), Positives = 107/314 (34%), Gaps = 44/314 (14%)
Query: 412 PHNCTD--NEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPI 469
P NC N F C +G CI + CD DC D SDE C +C+ +CK Q
Sbjct: 1232 PVNCEKKCNGFRC-PNGTCIPSSKHCDGLRDCSDGSDEQHCE-PLCTHFMDFVCKNRQQC 1289
Query: 470 PVHLLQDSNTFRWGLGNG-----ISIHHGEENHRPSVDHTQNTTDG------WYLYADSS 518
H + + G+ E H+ + +G W
Sbjct: 1290 LFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDD 1349
Query: 519 NGKFGDTADILTPIISLTGPKCTLVFWTHM-NGATVGSLQVLIKKDNVTSKLWAQTGQQG 577
G + D A+ P P C+ F NG + + ++++ W+ G
Sbjct: 1350 CGDYSDEANCENPT---EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGD--WSDEKDCG 1404
Query: 578 AQWKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVD------DISFQDCSPLLS------- 624
G + +R G + D D S ++ PLL+
Sbjct: 1405 DSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAAST 1464
Query: 625 PER--KCTDHEFMCAN-KHCIAKDKLCDFVNDCADNSDE------TTFICRTSSGRCDFE 675
P + +C EF C K CI K CD DC D DE +T C + +C+ +
Sbjct: 1465 PTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCE-D 1523
Query: 676 FDLCSWKQEKDEDF 689
+ C E+ + F
Sbjct: 1524 GEACIVLSERCDGF 1537
Score = 35.4 bits (80), Expect = 0.43
Identities = 16/41 (39%), Positives = 22/41 (53%), Gaps = 2/41 (4%)
Query: 844 PTGFCPLG--YRECHNGKCYRLEQSCNFVDNCGDNTGENKC 882
PT C L +R +G C L C+ D+CGDN+ E+ C
Sbjct: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHC 1153
Score = 34.7 bits (78), Expect = 0.73
Identities = 18/46 (39%), Positives = 23/46 (50%), Gaps = 2/46 (4%)
Query: 406 VPVTLP-PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
+P + P P C N + C S G C+ CD DC D SDE +C
Sbjct: 1409 LPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDGYRDCADGSDEEAC 1453
Score = 33.5 bits (75), Expect = 1.6
Identities = 19/57 (33%), Positives = 23/57 (40%), Gaps = 1/57 (1%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICNWEQDAKDDFDWT 250
F C ACI CD DC D +DE C+ EL ++ W D D T
Sbjct: 1519 FQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTV-YKVQNLQWTADFSGDVTLT 1574
Score = 33.1 bits (74), Expect = 2.1
Identities = 15/30 (50%), Positives = 16/30 (53%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
F C + CI S CD DCS SDE HC
Sbjct: 1242 FRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
Score = 32.7 bits (73), Expect = 2.8
Identities = 12/29 (41%), Positives = 17/29 (58%)
Query: 854 ECHNGKCYRLEQSCNFVDNCGDNTGENKC 882
+C NG C L C+ +D+CGD + E C
Sbjct: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
Score = 32.7 bits (73), Expect = 2.8
Identities = 13/31 (41%), Positives = 15/31 (48%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
F C + CI + CD DC D DE NC
Sbjct: 1476 FECHQPKTCIPNWKRCDGHQDCQDGRDEANC 1506
Score = 32.0 bits (71), Expect = 4.8
Identities = 22/72 (30%), Positives = 30/72 (41%), Gaps = 13/72 (18%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFET-----SSGN---WTTA 1176
+ C + CI S CD+ DC SDE +C T C+ +T SG +
Sbjct: 1083 YRCSNGNCINSIWWCDFDNDCGDMSDERNC-----PTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 1177 CSLTQDSEDDLD 1188
C L D D+ D
Sbjct: 1138 CDLEDDCGDNSD 1149
Score = 32.0 bits (71), Expect = 4.8
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 9/66 (13%)
Query: 629 CTDHEFMCAN-KHCIAKDKLCDFVNDCADNSDE-------TTFICRTSSGRCDFEFDL-C 679
C EF C + + CI + CD DC+D SDE T + + DF D+
Sbjct: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTL 1573
Query: 680 SWKQEK 685
+W + K
Sbjct: 1574 TWMRPK 1579
Score = 31.6 bits (70), Expect = 6.2
Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 6/50 (12%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSD------EAHCAHYTSTTGSC 1164
E ++F CR+ CI CD DC SD E C + G+C
Sbjct: 1200 EASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTC 1249
Score = 31.6 bits (70), Expect = 6.2
Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 12/59 (20%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNCAP------------ELQCNFETGICNWEQDAKDDFD 248
CI + CD + DC D +DE +C P QC F + +C+ +D D
Sbjct: 1249 CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 91.7 bits (226), Expect = 5e-18
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 12/137 (8%)
Query: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
Query: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
Query: 1445 ADCMDFQLDESSCSDTW 1461
DC + DE+ C+ TW
Sbjct: 152 KDC-EGGADEAGCA-TW 166
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
Query: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
+ S G + SW+ + ++D
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
E C+ E++ D D T+ P L+ GP
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
Score = 40.0 bits (92), Expect = 0.017
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
Query: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
+G C E C ++E + D
Sbjct: 94 DNGHCIHERWKCDGEEECPDGSD 116
Score = 35.0 bits (79), Expect = 0.56
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Score = 32.0 bits (71), Expect = 4.8
Identities = 14/39 (35%), Positives = 21/39 (53%), Gaps = 4/39 (10%)
Query: 1131 KCIASHLLCDYKPDCSGRSDEAHCAHYTS----TTGSCN 1165
KC+ + CD + DC G +DEA CA + + G C+
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCS 178
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 91.3 bits (225), Expect = 7e-18
Identities = 50/139 (35%), Positives = 66/139 (47%), Gaps = 10/139 (7%)
Query: 1324 ECVTGGPVPVQPSP--CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE--MDCPLNPTP 1379
+CV G P + C D+F C + +C+P KCDG +DC DGSDE +C
Sbjct: 3478 DCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEEC----DE 3533
Query: 1380 PLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQ 1439
C +F C + C+P CD DC N DE C+ + CS CA+ CI
Sbjct: 3534 RTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGR-CIAGRW 3592
Query: 1440 RCDGFADCMDFQLDESSCS 1458
+CDG DC D DE C+
Sbjct: 3593 KCDGDHDCADGS-DEKDCT 3610
Score = 86.3 bits (212), Expect = 2e-16
Identities = 48/131 (36%), Positives = 65/131 (49%), Gaps = 4/131 (3%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC-STDE 1393
P C D+F C C+PL +CDG DC+D SDE C T +++F C +
Sbjct: 1059 PGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCE-GVTHVCDPSVKFGCKDSAR 1117
Query: 1394 CIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNS-CIPAHQRCDGFADCMDFQL 1452
CI +CDG DC N DE C + +C + CA++ S C+P + CDG DC D
Sbjct: 1118 CISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGS- 1176
Query: 1453 DESSCSDTWTL 1463
DE D +L
Sbjct: 1177 DEGELCDQCSL 1187
Score = 84.3 bits (207), Expect = 8e-16
Identities = 49/125 (39%), Positives = 60/125 (48%), Gaps = 7/125 (5%)
Query: 1336 SPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEM-DCPLNPTPPLCSNMEFPCSTDEC 1394
S C A QF C +C+P KCD +DC D SDE DCP C +F CST C
Sbjct: 3332 SNCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDEPPDCPEFK----CRPGQFQCSTGIC 3386
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
+CDG DC N DE C C C ++N CIP RC+G +C D + DE
Sbjct: 3387 TNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGE-DE 3445
Query: 1455 SSCSD 1459
C +
Sbjct: 3446 RDCPE 3450
Score = 82.8 bits (203), Expect = 2e-15
Identities = 40/113 (35%), Positives = 53/113 (46%), Gaps = 7/113 (6%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C + F+C + +C+P+S CD +DC G DE C CS +F C CI
Sbjct: 2696 CPLNYFACP-SGRCIPMSWTCDKEDDCEHGEDETHCN-----KFCSEAQFECQNHRCISK 2749
Query: 1398 LLLCDGVPDCHFNEDELI-CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
LCDG DC DE C K+C + C ++ C+P CDG DC D
Sbjct: 2750 QWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCAD 2802
Score = 81.3 bits (199), Expect = 7e-15
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 15/124 (12%)
Query: 1342 QFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLC 1401
QF+C +C+ ++ +CD DC D SDE C + CS+ +F C++ CIP C
Sbjct: 981 QFTC-NNGRCININWRCDNDNDCGDNSDEAGCSHS-----CSSTQFKCNSGRCIPEHWTC 1034
Query: 1402 DGVPDC--HFNEDELICSNKS------CSNGALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
DG DC + +E C+N++ C C CIP RCDG DCMD D
Sbjct: 1035 DGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMD-SSD 1093
Query: 1454 ESSC 1457
E SC
Sbjct: 1094 EKSC 1097
Score = 79.0 bits (193), Expect = 3e-14
Identities = 51/124 (41%), Positives = 65/124 (52%), Gaps = 8/124 (6%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTP-PLCSNMEFPCSTDECIP 1396
C +QFSC + +C+P+S CD +DC D SDE PT PL +F C+ CI
Sbjct: 936 CPPNQFSCA-SGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPL---TQFTCNNGRCIN 991
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
CD DC N DE CS+ SCS+ C +S CIP H CDG DC D+ DE+
Sbjct: 992 INWRCDNDNDCGDNSDEAGCSH-SCSSTQFKC-NSGRCIPEHWTCDGDNDCGDYS-DETH 1048
Query: 1457 CSDT 1460
+ T
Sbjct: 1049 ANCT 1052
Score = 78.6 bits (192), Expect = 4e-14
Identities = 49/164 (29%), Positives = 74/164 (45%), Gaps = 19/164 (11%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCS-TDECIP 1396
C QF C + C + CDG DC D SDE +C ++ +C +F C+ T+ CIP
Sbjct: 3374 CRPGQFQCSTGI-CTNPAFICDGDNDCQDNSDEANCDIH----VCLPSQFKCTNTNRCIP 3428
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
+ C+G +C EDE C +C+ C+ + CIP CD DC+D + ++
Sbjct: 3429 GIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPAN 3488
Query: 1457 CSDTWTLLGIGLAFLMTHITVAVLCFLANRKVPIR-KTEGSGNC 1499
C+ MT C + R +P R K +G +C
Sbjct: 3489 CTQ------------MTCGVDEFRCKDSGRCIPARWKCDGEDDC 3520
Score = 77.4 bits (189), Expect = 1e-13
Identities = 45/113 (39%), Positives = 50/113 (44%), Gaps = 3/113 (2%)
Query: 1345 CIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGV 1404
C T C S CDG DC D SDE DCP P C F C + CIP CD
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDCP-GVKRPRCPLNYFACPSGRCIPMSWTCDKE 2718
Query: 1405 PDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
DC EDE C NK CS C ++ CI CDG DC D + + C
Sbjct: 2719 DDCEHGEDETHC-NKFCSEAQFEC-QNHRCISKQWLCDGSDDCGDGSDEAAHC 2769
Score = 76.3 bits (186), Expect = 2e-13
Identities = 46/122 (37%), Positives = 54/122 (44%), Gaps = 8/122 (6%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE---MDCPLNPTPPLCSNMEFPCSTDEC 1394
C FSC T CVP CDG +DC DG+DE C N T C + EF C +C
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNST---CDDREFMCQNRQC 2830
Query: 1395 IPSLLLCDGVPDCHFNEDEL-ICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLD 1453
IP +CD DC DE C +C CA+ CDG DC D Q D
Sbjct: 2831 IPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHD-QSD 2889
Query: 1454 ES 1455
E+
Sbjct: 2890 EA 2891
Score = 75.1 bits (183), Expect = 5e-13
Identities = 47/137 (34%), Positives = 60/137 (43%), Gaps = 7/137 (5%)
Query: 1324 ECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCS 1383
+C G C+ DQF C + C+PL +CD DC+DGSDE C C
Sbjct: 3599 DCADGSDEKDCTPRCDMDQFQC-KSGHCIPLRWRCDADADCMDGSDEEACGTGVR--TCP 3655
Query: 1384 NMEFPCSTDECIPSLLLCDGVPDCHFNEDE--LICSNKSC-SNGALVCASSNSCIPAHQR 1440
EF C+ C P CDG DC N DE C+ C N C + C+ ++
Sbjct: 3656 LDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQ 3715
Query: 1441 CDGFADCMDFQLDESSC 1457
CDG +C D DE C
Sbjct: 3716 CDGTDNCGD-GTDEEDC 3731
Score = 74.7 bits (182), Expect = 6e-13
Identities = 45/126 (35%), Positives = 58/126 (46%), Gaps = 6/126 (4%)
Query: 1336 SPCEA-DQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDEC 1394
S C A D+F C +C+ S CDG C D SDE N C CS C
Sbjct: 2522 SSCRAQDEFECANG-ECINFSLTCDGVPHCKDKSDEKPSYCNSRR--CKKTFRQCSNGRC 2578
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
+ ++L C+G DC DE+ C+ +C G C +CI RC+ F DC D DE
Sbjct: 2579 VSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC-RDGTCIGNSSRCNQFVDCEDAS-DE 2636
Query: 1455 SSCSDT 1460
+CS T
Sbjct: 2637 MNCSAT 2642
Score = 71.6 bits (174), Expect = 5e-12
Identities = 44/125 (35%), Positives = 54/125 (43%), Gaps = 10/125 (8%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPC-STDECIP 1396
C QF C +C+ CDG +DC DGSDE T C F C T C+P
Sbjct: 2734 CSEAQFEC-QNHRCISKQWLCDGSDDCGDGSDEAAHCEGKT---CGPSSFSCPGTHVCVP 2789
Query: 1397 SLLLCDGVPDCHFNEDELICS----NKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
LCDG DC DE I + N +C + +C + CIP H CD DC D
Sbjct: 2790 ERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMC-QNRQCIPKHFVCDHDRDCADGSD 2848
Query: 1453 DESSC 1457
+ C
Sbjct: 2849 ESPEC 2853
Score = 69.7 bits (169), Expect = 2e-11
Identities = 43/131 (32%), Positives = 59/131 (45%), Gaps = 7/131 (5%)
Query: 1333 VQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPT---PPLCSNMEFPC 1389
V + C + C P S +C ED + +D + C NP+ PP C EF C
Sbjct: 802 VGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGEFAC 861
Query: 1390 STDECIPSLLLCDGVPDCHFNEDE--LICSNKSCSNGALVCASSNSCIPAHQRCDGFADC 1447
+ CI CDG DC N DE +C +C + C +N CIP CDG DC
Sbjct: 862 ANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKC-ENNRCIPNRWLCDGDNDC 920
Query: 1448 MDFQLDESSCS 1458
+ + DES+ +
Sbjct: 921 GNSE-DESNAT 930
Score = 67.0 bits (162), Expect = 1e-10
Identities = 92/402 (22%), Positives = 134/402 (33%), Gaps = 85/402 (21%)
Query: 1122 ITDFLCRDK-KCIASHLLCDYKPDCSGRSDEA--------------HCAHYTSTTG--SC 1164
+ +F C+D +CI + CD + DC SDE C + G C
Sbjct: 3496 VDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRWQC 3555
Query: 1165 NFETSSGNWTT--ACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGS 1222
+++ G+ + +C+ SE + A G I + D DH + GS
Sbjct: 3556 DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKC-DGDHDC----------ADGS 3604
Query: 1223 KEGSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKR 1282
E F G C W D M + EE+
Sbjct: 3605 DEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMD----GSDEEA-------------- 3646
Query: 1283 TGWTYGSVPLSS---NSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCE 1339
G + PL N+ DG +D D+ EC P +P C+
Sbjct: 3647 CGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENP--EECARFVCPPNRPFRCK 3704
Query: 1340 ADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDC--PLNPTPPLCSNMEFPCSTDECIPS 1397
D+ C+ + +CDG ++C DG+DE DC P T EF C C+ S
Sbjct: 3705 NDRV-------CLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSS 3757
Query: 1398 LLLCDGVPDCHFNEDELICS----NKSCSNGALVCASSNSC-----------------IP 1436
L C+ DC DE CS SC+ A +C C +P
Sbjct: 3758 SLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAYCACRSGFHTVP 3817
Query: 1437 AHQRCDGFADCMDFQLDESSCSDT--WTLLGIGLAFLMTHIT 1476
C +C+ F C++T L F+ TH T
Sbjct: 3818 GQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNT 3859
Score = 66.2 bits (160), Expect = 2e-10
Identities = 41/124 (33%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD--CPLNPTPPLCSNMEFPCSTDECI 1395
C +D+F C +C+P CDG DC + DE + C PP +F C++ CI
Sbjct: 895 CPSDRFKCENN-RCIPNRWLCDGDNDCGNSEDESNATCSARTCPP----NQFSCASGRCI 949
Query: 1396 PSLLLCDGVPDCHFNEDE-LICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
P CD DC DE C+ +C ++ CI + RCD DC D DE
Sbjct: 950 PISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCDNDNDCGD-NSDE 1008
Query: 1455 SSCS 1458
+ CS
Sbjct: 1009 AGCS 1012
Score = 64.7 bits (156), Expect = 7e-10
Identities = 41/144 (28%), Positives = 57/144 (39%), Gaps = 18/144 (12%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMD--CPLNPTPPLCSNMEFPCSTD 1392
P C QF+C + C+ +CDG DC DGSDE CP + N T+
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTE 83
Query: 1393 ECIPSLLLCDGVPDC--------HFNEDELICSNKSCSNGAL--------VCASSNSCIP 1436
C+P LC+GV DC H E + CS C + + C SS
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
Query: 1437 AHQRCDGFADCMDFQLDESSCSDT 1460
+ C F +C + C++T
Sbjct: 144 DGKTCKDFDECSVYGTCSQLCTNT 167
Score = 63.2 bits (152), Expect = 2e-09
Identities = 94/379 (24%), Positives = 132/379 (34%), Gaps = 53/379 (13%)
Query: 1083 PEPECPRGRSALLKGPPQEE----PNRRSALLSVGEISELCPEIT----DFLCRDKKCIA 1134
P P+C G A +E L + E LC + T F C + +CI
Sbjct: 850 PPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIP 909
Query: 1135 SHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSG-----NWTTACSLTQDSEDDLDW 1189
+ LCD DC DE++ T F +SG +WT C L D D D
Sbjct: 910 NRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWT--CDLDDDCGDRSDE 967
Query: 1190 AIGSRIPAKALIPDSDHTPGSGQHFLYVN---------SSGSKEGSVARITTSKSFPASL 1240
+ P P + T +G+ + +N S E + +S F +
Sbjct: 968 SASCAYP--TCFPLTQFTCNNGR-CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNS 1024
Query: 1241 GMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTYGSVPLSSNSPFKV 1300
G C W D G +E+ N + + G + +
Sbjct: 1025 GRCIPEHWTCDGD-NDCGDYS----DETHANC---TNQATRPPGGCHTDEFQCRLDGLCI 1076
Query: 1301 AFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDG 1360
DG+ D + D+ S E VT P C+ D CI + CDG
Sbjct: 1077 PLRWRCDGDTDCMDSSDEKSC--EGVTHVCDPSVKFGCK-DSARCI------SKAWVCDG 1127
Query: 1361 HEDCIDGSDEMDCPLNPTPPLCSNMEFPC--STDECIPSLLLCDGVPDCHFNEDE-LICS 1417
DC D SDE +C C PC +T C+P LCDG DC DE +C
Sbjct: 1128 DNDCEDNSDEENC----ESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD 1183
Query: 1418 NKSCSNGALVCASSNSCIP 1436
S +NG C+ + S P
Sbjct: 1184 QCSLNNGG--CSHNCSVAP 1200
Score = 62.4 bits (150), Expect = 3e-09
Identities = 42/117 (35%), Positives = 53/117 (45%), Gaps = 14/117 (11%)
Query: 1350 QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHF 1409
+CV C+G +DC DGSDE+ C N T C EF C CI + C+ DC
Sbjct: 2577 RCVSNMLWCNGADDCGDGSDEIPC--NKTA--CGVGEFRCRDGTCIGNSSRCNQFVDCED 2632
Query: 1410 NEDELICSNKSCSN-------GALV--CASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
DE+ CS CS+ G L C ++ C CDG DC D+ DE C
Sbjct: 2633 ASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYS-DERDC 2688
Score = 54.3 bits (129), Expect = 9e-07
Identities = 40/130 (30%), Positives = 61/130 (46%), Gaps = 23/130 (17%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCS----TDE 1393
C+ ++ +C+ T CVP+S C+G +DC+DGSDE P C ++ CS
Sbjct: 72 CQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE--------GPHCRELQGNCSRLGCQHH 123
Query: 1394 CIPSLLLCDGVPDCHFNED-ELICSNKSCSNGALVCASSNSCIPAHQRCDG--FADCMD- 1449
C+P+L DG P C+ N +L K+C + C+ +C DG C++
Sbjct: 124 CVPTL---DG-PTCYCNSSFQLQADGKTCKDFD-ECSVYGTCSQLCTNTDGSFICGCVEG 178
Query: 1450 --FQLDESSC 1457
Q D SC
Sbjct: 179 YLLQPDNRSC 188
Score = 53.1 bits (126), Expect = 2e-06
Identities = 42/142 (29%), Positives = 55/142 (38%), Gaps = 27/142 (19%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNME--------FPC 1389
C +F C +CDG DC D SDE P P C++ E F C
Sbjct: 2858 CGPSEFRCANGRCLSSRQWECDGENDCHDQSDEA-----PKNPHCTSQEHKCNASSQFLC 2912
Query: 1390 STDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSN----------SCIPAHQ 1439
S+ C+ LLC+G DC + DE C C + L S + C P +
Sbjct: 2913 SSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFR 2972
Query: 1440 RCDGFADCMDFQLDESSCSDTW 1461
D C D +DE CS T+
Sbjct: 2973 LKDDGRTCAD--VDE--CSTTF 2990
Score = 51.6 bits (122), Expect = 6e-06
Identities = 27/58 (46%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 409 TLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC--VMEVCSFEKRSLCK 464
T PP C +EF CR DG CI +CD DC D SDE SC V VC + CK
Sbjct: 1056 TRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCK 1113
Score = 50.4 bits (119), Expect = 1e-05
Identities = 32/91 (35%), Positives = 42/91 (46%), Gaps = 4/91 (4%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTF----ICRTSSGRCDFEFDLCSWKQE 684
C D EFMC N+ CI K +CD DCAD SDE+ C S RC L S + E
Sbjct: 2818 CDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWE 2877
Query: 685 KDEDFDWNLKASSIPAAGTEPAADHTLGNSS 715
D + D + ++ P + +H SS
Sbjct: 2878 CDGENDCHDQSDEAPKNPHCTSQEHKCNASS 2908
Score = 50.1 bits (118), Expect = 2e-05
Identities = 67/277 (24%), Positives = 91/277 (32%), Gaps = 27/277 (9%)
Query: 409 TLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVCSFEKRSLCKWYQ 467
T C N+F C S G CI CD DC D+SDE ASC C + C +
Sbjct: 930 TCSARTCPPNQFSCAS-GRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGR 988
Query: 468 PIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTAD 527
I ++ D++ + H + + + + + W D+ G + D
Sbjct: 989 CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDE-- 1046
Query: 528 ILTPIISLTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKL-WAQTGQQGAQWKRAEVF 586
T CT G Q + D + L W G E
Sbjct: 1047 --------THANCTNQATRPPGGCHTDEFQCRL--DGLCIPLRWRCDGDTDCMDSSDEKS 1096
Query: 587 LGIRSHT---QIVFRAKRGISYIGDVAVDDISFQDCSPLLSPER----KCTDHEFMCANK 639
+H + F K I V D DC E C CAN
Sbjct: 1097 CEGVTHVCDPSVKFGCKDSARCISKAWVCD-GDNDCEDNSDEENCESLACRPPSHPCANN 1155
Query: 640 H--CIAKDKLCDFVNDCADNSDETTFI--CRTSSGRC 672
C+ DKLCD +DC D SDE C ++G C
Sbjct: 1156 TSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGC 1192
Score = 48.9 bits (115), Expect = 4e-05
Identities = 28/76 (36%), Positives = 35/76 (46%), Gaps = 15/76 (19%)
Query: 626 ERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSD----------ETTFIC---RTSSGR- 671
ER C ++F C N C+ CD+ NDC DNSD E+ F C R +GR
Sbjct: 3533 ERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRW 3592
Query: 672 -CDFEFDLCSWKQEKD 686
CD + D EKD
Sbjct: 3593 KCDGDHDCADGSDEKD 3608
Score = 47.8 bits (112), Expect = 8e-05
Identities = 21/46 (45%), Positives = 25/46 (54%)
Query: 620 SPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
+P P +C EF CAN CI + CD NDC DNSDE +C
Sbjct: 845 NPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALC 890
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/53 (41%), Positives = 28/53 (52%), Gaps = 3/53 (5%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCK 464
P C+ +F CR CI K +CD + DCPD SDEA E+C K C+
Sbjct: 24 PKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAP---EICPQSKAQRCQ 73
Score = 46.2 bits (108), Expect = 2e-04
Identities = 64/272 (23%), Positives = 95/272 (34%), Gaps = 50/272 (18%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474
C EF CR DG CI +C+ DC D SDE +C C
Sbjct: 2605 CGVGEFRCR-DGTCIGNSSRCNQFVDCEDASDEMNCSATDC------------------- 2644
Query: 475 QDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIIS 534
S+ FR G+ G+ E R S+ + + W + G + D D
Sbjct: 2645 --SSYFRLGV-KGVLFQPCE---RTSLCYAPS----WVCDGANDCGDYSDERD----CPG 2690
Query: 535 LTGPKCTLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRAEVFLGIRSHTQ 594
+ P+C L ++ +G + K+D+ + G F S Q
Sbjct: 2691 VKRPRCPLNYFACPSGRCIPMSWTCDKEDDC---------EHGEDETHCNKFC---SEAQ 2738
Query: 595 IVFRAKRGIS--YIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANKH-CIAKDKLCDFV 651
+ R IS ++ D DD + C F C H C+ + LCD
Sbjct: 2739 FECQNHRCISKQWLCD-GSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGD 2797
Query: 652 NDCADNSDETTFICRTSSGRCDFEFDLCSWKQ 683
DCAD +DE+ + CD +C +Q
Sbjct: 2798 KDCADGADESIAAGCLYNSTCDDREFMCQNRQ 2829
Score = 45.8 bits (107), Expect = 3e-04
Identities = 79/334 (23%), Positives = 116/334 (34%), Gaps = 47/334 (14%)
Query: 407 PVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEAS--CVMEVCSFEKRSLCK 464
P +PP C EF C ++ CI++ KCD DC D SDEA C C + R C+
Sbjct: 846 PSYVPPPQCQPGEFAC-ANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSD-RFKCE 903
Query: 465 WYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNGKFGD 524
+ IP L D + GN + + R + + G + + D
Sbjct: 904 NNRCIPNRWLCDGDN---DCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDD 960
Query: 525 TADILTPIISLTGPKC-TLVFWTHMNGATVGSLQVLIKKDNVTSKLWAQTGQQGAQWKRA 583
D S P C L +T NG + ++ DN + G +
Sbjct: 961 CGDRSDESASCAYPTCFPLTQFTCNNGRCI-NINWRCDNDNDCGDNSDEAGCSHS----- 1014
Query: 584 EVFLGIRSHTQIVFRAKR---------GISYIGDVAVDDISFQDCSPLLSPERKCTDHEF 634
S TQ + R G + GD + D+ + P C EF
Sbjct: 1015 ------CSSTQFKCNSGRCIPEHWTCDGDNDCGDYS-DETHANCTNQATRPPGGCHTDEF 1067
Query: 635 MC-ANKHCIAKDKLCDFVNDCADNSDE-----TTFICRTS-------SGRCDFEFDLCSW 681
C + CI CD DC D+SDE T +C S S RC + +W
Sbjct: 1068 QCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISK----AW 1123
Query: 682 KQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSS 715
+ D D + N + + P + N+S
Sbjct: 1124 VCDGDNDCEDNSDEENCESLACRPPSHPCANNTS 1157
Score = 45.1 bits (105), Expect = 5e-04
Identities = 29/98 (29%), Positives = 41/98 (41%), Gaps = 13/98 (13%)
Query: 833 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTF---- 888
D E + PT F PL C+NG+C + C+ ++CGDN+ E C SC+
Sbjct: 963 DRSDESASCAYPTCF-PLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFK 1021
Query: 889 --------EKGWCGWQNSQADNFDWVLGVGSHQSLRPP 918
E C N D D ++Q+ RPP
Sbjct: 1022 CNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPP 1059
Score = 45.1 bits (105), Expect = 5e-04
Identities = 20/63 (31%), Positives = 35/63 (55%), Gaps = 1/63 (1%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQDS 1183
+F+C++++CI H +CD+ DC+ SDE+ Y T G F ++G ++ D
Sbjct: 2822 EFMCQNRQCIPKHFVCDHDRDCADGSDESPECEY-PTCGPSEFRCANGRCLSSRQWECDG 2880
Query: 1184 EDD 1186
E+D
Sbjct: 2881 END 2883
Score = 44.3 bits (103), Expect = 0.001
Identities = 34/99 (34%), Positives = 46/99 (46%), Gaps = 9/99 (9%)
Query: 150 SQPFHLSLDKVSLGI---YDGVSAIDDIRFENCTLPLPAES--CEGLDHFWCRHTRACIE 204
++PF D+V L I DG D E P A + C+ F CR+ R
Sbjct: 3698 NRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSS 3757
Query: 205 KLRLCDLVDDCGDRTDEVNCA--PEL-QCNFETGICNWE 240
LR C++ DDCGD +DE +C+ P+L C IC E
Sbjct: 3758 SLR-CNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDE 3795
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 13/65 (20%)
Query: 186 ESCEGLDH-------FWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNF 232
+SCEG+ H F C+ + CI K +CD +DC D +DE NC P C
Sbjct: 1095 KSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCAN 1154
Query: 233 ETGIC 237
T +C
Sbjct: 1155 NTSVC 1159
Score = 43.1 bits (100), Expect = 0.002
Identities = 23/64 (35%), Positives = 28/64 (43%), Gaps = 3/64 (4%)
Query: 612 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT---FICRTS 668
DD P PE KC +F C+ C +CD NDC DNSDE +C S
Sbjct: 3357 DDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPS 3416
Query: 669 SGRC 672
+C
Sbjct: 3417 QFKC 3420
Score = 43.1 bits (100), Expect = 0.002
Identities = 18/50 (36%), Positives = 26/50 (52%), Gaps = 1/50 (2%)
Query: 612 DDISFQDCSPLLSPERKCTDH-EFMCANKHCIAKDKLCDFVNDCADNSDE 660
D +DC P + C D EF+C N+ C++ C+ +DC D SDE
Sbjct: 3724 DGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDE 3773
Score = 42.7 bits (99), Expect = 0.003
Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 412 PHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPV 471
P C+++EF C ++G CI KCD +DC D SDE C C ++ CK IP+
Sbjct: 3572 PRPCSESEFSC-ANGRCIAGRWKCDGDHDCADGSDEKDCTPR-CDMDQFQ-CKSGHCIPL 3628
Query: 472 HLLQDSN 478
D++
Sbjct: 3629 RWRCDAD 3635
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 9/72 (12%)
Query: 625 PERKCTDHEFMCA-NKHCIAKDKLCDFVNDCADNSDE----TTFICRTSSGRCDFEFDLC 679
PE C ++F C+ K CI + +CD NDC D SDE T C RC + C
Sbjct: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCK-DSGRC 3507
Query: 680 ---SWKQEKDED 688
WK + ++D
Sbjct: 3508 IPARWKCDGEDD 3519
Score = 40.4 bits (93), Expect = 0.013
Identities = 38/136 (27%), Positives = 52/136 (38%), Gaps = 14/136 (10%)
Query: 1305 DLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEAD-QFSCIYTLQCVPLSGKCDGHED 1363
+ DG D D+ P C + Q C A QF C + +CV + C+G +D
Sbjct: 2877 ECDGENDCHDQSDEAPKNPHCTS------QEHKCNASSQFLCS-SGRCVAEALLCNGQDD 2929
Query: 1364 CIDGSDEMDCPLNPTPPLCSNMEFPCSTD-ECIPSLLLCDGVPDCHFNEDELICSNKSCS 1422
C D SDE C +N S CS D E + C P +D C++
Sbjct: 2930 CGDSSDERGCHIN---ECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDEC 2986
Query: 1423 NGALVCASSNSCIPAH 1438
+ C S CI H
Sbjct: 2987 STTFPC--SQRCINTH 3000
Score = 40.4 bits (93), Expect = 0.013
Identities = 15/37 (40%), Positives = 24/37 (64%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
C + +FLCR+++C++S L C+ DC SDE C+
Sbjct: 3741 CKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCS 3777
Score = 40.0 bits (92), Expect = 0.017
Identities = 20/49 (40%), Positives = 23/49 (46%), Gaps = 1/49 (2%)
Query: 407 PVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
P P C +F C S G C CD DC D SDEA+C + VC
Sbjct: 3366 PPDCPEFKCRPGQFQC-STGICTNPAFICDGDNDCQDNSDEANCDIHVC 3413
Score = 39.7 bits (91), Expect = 0.023
Identities = 22/48 (45%), Positives = 23/48 (47%), Gaps = 2/48 (4%)
Query: 633 EFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEFDLCS 680
EF CAN CI CD V C D SDE C +S RC F CS
Sbjct: 2529 EFECANGECINFSLTCDGVPHCKDKSDEKPSYC--NSRRCKKTFRQCS 2574
Score = 39.7 bits (91), Expect = 0.023
Identities = 20/56 (35%), Positives = 28/56 (50%), Gaps = 2/56 (3%)
Query: 409 TLPPHNCT-DNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLC 463
T H C ++F+C S G C+ + C+ + DC D SDE C + C K S C
Sbjct: 2898 TSQEHKCNASSQFLC-SSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGC 2952
Score = 39.7 bits (91), Expect = 0.023
Identities = 24/80 (30%), Positives = 34/80 (42%), Gaps = 16/80 (20%)
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
+DC+P +C +F C + HCI CD DC D SDE C T C +
Sbjct: 3607 KDCTP------RCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEA--CGTGVRTCPLDE 3658
Query: 677 DLC--------SWKQEKDED 688
C +WK + ++D
Sbjct: 3659 FQCNNTLCKPLAWKCDGEDD 3678
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/85 (30%), Positives = 33/85 (38%), Gaps = 10/85 (11%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENK-------CGSSCTF---EKGWCGWQN 897
CPL +C+N C L C+ D+CGDN+ EN C + F C W
Sbjct: 3654 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIG 3713
Query: 898 SQADNFDWVLGVGSHQSLRPPKDHT 922
Q D D + PP HT
Sbjct: 3714 RQCDGTDNCGDGTDEEDCEPPTAHT 3738
Score = 39.3 bits (90), Expect = 0.030
Identities = 17/34 (50%), Positives = 23/34 (67%), Gaps = 1/34 (2%)
Query: 414 NCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
NCT ++F+C++D CI KCD + DC D SDE
Sbjct: 3333 NCTASQFVCKND-KCIPFWWKCDTEDDCGDHSDE 3365
Score = 39.3 bits (90), Expect = 0.030
Identities = 19/41 (46%), Positives = 22/41 (53%), Gaps = 5/41 (12%)
Query: 412 PHNCTD-----NEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
P NCT +EF C+ G CI KCD + DC D SDE
Sbjct: 3486 PANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526
Score = 38.5 bits (88), Expect = 0.051
Identities = 17/59 (28%), Positives = 28/59 (47%), Gaps = 2/59 (3%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWV 906
CPL Y C +G+C + +C+ D+C E C C+ + C QN + + W+
Sbjct: 2696 CPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFEC--QNHRCISKQWL 2752
Score = 38.5 bits (88), Expect = 0.051
Identities = 16/38 (42%), Positives = 25/38 (65%), Gaps = 1/38 (2%)
Query: 624 SPERKCT-DHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
S E KC +F+C++ C+A+ LC+ +DC D+SDE
Sbjct: 2899 SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDE 2936
Score = 38.5 bits (88), Expect = 0.051
Identities = 18/50 (36%), Positives = 24/50 (48%), Gaps = 1/50 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE-ASCVMEVCSFEK 459
P C N+F C CI ++ CD DC D SDE A+C C ++
Sbjct: 3449 PEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDE 3498
Score = 38.5 bits (88), Expect = 0.051
Identities = 25/86 (29%), Positives = 33/86 (38%), Gaps = 17/86 (19%)
Query: 1114 EISELCPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTG 1162
E E C E T F C++ +C+ CDY DC SDE C + ++ G
Sbjct: 3526 EPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
Query: 1163 SCNFETSSGNWTTACSLTQDSEDDLD 1188
C +G W C D D D
Sbjct: 3586 RC----IAGRW--KCDGDHDCADGSD 3605
Score = 38.5 bits (88), Expect = 0.051
Identities = 16/42 (38%), Positives = 23/42 (54%), Gaps = 1/42 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
C +F C+++ C+ +CD+ DC D SDE SC CS
Sbjct: 3536 CEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCTPRPCS 3576
Score = 38.5 bits (88), Expect = 0.051
Identities = 17/36 (47%), Positives = 22/36 (61%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
C ++F C+S GHCI +CD DC D SDE +C
Sbjct: 3613 CDMDQFQCKS-GHCIPLRWRCDADADCMDGSDEEAC 3647
Score = 38.1 bits (87), Expect = 0.066
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 4/48 (8%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----TTFICRTSSGRC 672
CT +F+C N CI CD +DC D+SDE F CR +C
Sbjct: 3334 CTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQC 3381
Score = 37.7 bits (86), Expect = 0.087
Identities = 21/58 (36%), Positives = 28/58 (48%), Gaps = 7/58 (12%)
Query: 186 ESCEGL-----DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFETGICN 238
E+CE L H +T C+ +LCD DDCGD +DE QC+ G C+
Sbjct: 1138 ENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD--QCSLNNGGCS 1193
Score = 37.7 bits (86), Expect = 0.087
Identities = 15/36 (41%), Positives = 20/36 (55%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
C + FLC +C+A LLC+ + DC SDE C
Sbjct: 2904 CNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC 2939
Score = 37.4 bits (85), Expect = 0.11
Identities = 25/64 (39%), Positives = 28/64 (43%), Gaps = 10/64 (15%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDE------VNCAPELQCNFETGIC---NWEQD 242
+ F C R CI CDL DDCGDR+DE C P Q G C NW D
Sbjct: 939 NQFSCASGR-CIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININWRCD 997
Query: 243 AKDD 246
+D
Sbjct: 998 NDND 1001
Score = 37.4 bits (85), Expect = 0.11
Identities = 29/94 (30%), Positives = 36/94 (38%), Gaps = 7/94 (7%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTG-SC-NFETSSGNWTTA 1176
CP + F C +CI CD + DC DE HC + S C N S W
Sbjct: 2696 CP-LNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISKQW--L 2752
Query: 1177 CSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS 1210
C + D D D A + K P S PG+
Sbjct: 2753 CDGSDDCGDGSDEA--AHCEGKTCGPSSFSCPGT 2784
Score = 37.4 bits (85), Expect = 0.11
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 13/67 (19%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQC-----NFETG-------ICNWEQ 241
F C++ + CI CD DDCGD +DE PE +C TG IC+ +
Sbjct: 3339 FVCKNDK-CIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDN 3397
Query: 242 DAKDDFD 248
D +D+ D
Sbjct: 3398 DCQDNSD 3404
Score = 37.4 bits (85), Expect = 0.11
Identities = 22/65 (33%), Positives = 34/65 (52%), Gaps = 11/65 (16%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDE-VNC------APELQCNFETGIC---NWEQ 241
+ F C T+ CI ++ +CD +DC D +DE NC E +C ++G C W+
Sbjct: 3456 NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCK-DSGRCIPARWKC 3514
Query: 242 DAKDD 246
D +DD
Sbjct: 3515 DGEDD 3519
Score = 37.0 bits (84), Expect = 0.15
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 5/59 (8%)
Query: 618 DCSPLLSPERK---CTDHEFMCANKH-CIAKDKLCDFVNDCADNSDETTFICRTSSGRC 672
D +P + P+ K C +E C C+ +LC+ V DC D SDE CR G C
Sbjct: 58 DEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPH-CRELQGNC 115
Score = 37.0 bits (84), Expect = 0.15
Identities = 14/38 (36%), Positives = 20/38 (52%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSS 885
C +R+C NG+C CN D+CGD + E C +
Sbjct: 2566 CKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKT 2603
Score = 37.0 bits (84), Expect = 0.15
Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 4/45 (8%)
Query: 190 GLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFET 234
G+D F C+ + CI CD DDCGD +DE P+ +C+ T
Sbjct: 3495 GVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE----PKEECDERT 3535
Score = 36.6 bits (83), Expect = 0.19
Identities = 23/71 (32%), Positives = 32/71 (45%), Gaps = 12/71 (16%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTD-----EVNCAP-ELQCNF------ETGICNWEQ 241
F C +T CI + C+ D+CGD D EV CAP + QC+ +C+ +
Sbjct: 3418 FKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDN 3477
Query: 242 DAKDDFDWTRN 252
D D D N
Sbjct: 3478 DCVDGSDEPAN 3488
Score = 36.2 bits (82), Expect = 0.25
Identities = 18/48 (37%), Positives = 27/48 (56%), Gaps = 2/48 (4%)
Query: 627 RKCTDHEFMCANK-HCIAKDKLCDFVNDCADNSDETTFIC-RTSSGRC 672
+ C+ +F C ++ CI+K CD DC D SDE IC ++ + RC
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRC 72
Score = 36.2 bits (82), Expect = 0.25
Identities = 25/77 (32%), Positives = 36/77 (46%), Gaps = 15/77 (19%)
Query: 178 NCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC-----APELQCNF 232
+C P +C L F C + R CI CD +DCGD +DE C + + +CN
Sbjct: 970 SCAYP----TCFPLTQFTCNNGR-CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCN- 1023
Query: 233 ETGIC---NWEQDAKDD 246
+G C +W D +D
Sbjct: 1024 -SGRCIPEHWTCDGDND 1039
Score = 36.2 bits (82), Expect = 0.25
Identities = 23/68 (33%), Positives = 31/68 (45%), Gaps = 14/68 (20%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDEV-------------NCAPELQCNFETGICNWE 240
F C++ R CI K LCD DDCGD +DE +C C E +C+ +
Sbjct: 2739 FECQNHR-CISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGD 2797
Query: 241 QDAKDDFD 248
+D D D
Sbjct: 2798 KDCADGAD 2805
Score = 36.2 bits (82), Expect = 0.25
Identities = 23/72 (31%), Positives = 33/72 (45%), Gaps = 6/72 (8%)
Query: 1123 TDFLCRDKKCIASHLLCDYKPDCSGRSDE-AHCAHYTSTTGSCNFETSSG---NWTTACS 1178
+ F+C++ KCI CD + DC SDE C + G F+ S+G N C
Sbjct: 3337 SQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPG--QFQCSTGICTNPAFICD 3394
Query: 1179 LTQDSEDDLDWA 1190
D +D+ D A
Sbjct: 3395 GDNDCQDNSDEA 3406
Score = 36.2 bits (82), Expect = 0.25
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 2/55 (3%)
Query: 400 TPPETSVPVTLPPHNCTDN-EFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVME 453
T E P T +C D EF+CR+ C+ +C+ DC D SDE C ++
Sbjct: 3726 TDEEDCEPPTAHTTHCKDKKEFLCRNQ-RCLSSSLRCNMFDDCGDGSDEEDCSID 3779
Score = 35.8 bits (81), Expect = 0.33
Identities = 19/65 (29%), Positives = 29/65 (44%), Gaps = 3/65 (4%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE---ASCVMEVCSFEKRSLCKWYQPIPV 471
C + F C C+ + CD DC D +DE A C+ ++ +C+ Q IP
Sbjct: 2774 CGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQNRQCIPK 2833
Query: 472 HLLQD 476
H + D
Sbjct: 2834 HFVCD 2838
Score = 35.8 bits (81), Expect = 0.33
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 12/74 (16%)
Query: 184 PAESCEGLD----HFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP----ELQCNFETG 235
P E C+ F C++ R C+ CD +DCGD +DE +C P E + + G
Sbjct: 3527 PKEECDERTCEPYQFRCKNNR-CVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCANG 3585
Query: 236 IC---NWEQDAKDD 246
C W+ D D
Sbjct: 3586 RCIAGRWKCDGDHD 3599
Score = 35.4 bits (80), Expect = 0.43
Identities = 16/59 (27%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGEN-KCGSSCTFEKGWCGWQNSQADNFDW 905
CP C +G+C + +C+ D+CGD + E+ C F N + N +W
Sbjct: 936 CPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGRCININW 994
Score = 35.4 bits (80), Expect = 0.43
Identities = 18/42 (42%), Positives = 22/42 (52%), Gaps = 2/42 (4%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA-SCVMEVC 455
C D EF+C++ CI K CD DC D SDE+ C C
Sbjct: 2818 CDDREFMCQNR-QCIPKHFVCDHDRDCADGSDESPECEYPTC 2858
Score = 35.0 bits (79), Expect = 0.56
Identities = 15/45 (33%), Positives = 19/45 (42%), Gaps = 5/45 (11%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKCG-----SSCTFEKGWCG 894
C N +C CN D+CGD + E C +SC CG
Sbjct: 3749 CRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICG 3793
Score = 34.7 bits (78), Expect = 0.73
Identities = 17/39 (43%), Positives = 18/39 (46%)
Query: 627 RKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC 665
R C EF C N C CD +DC DNSDE C
Sbjct: 3652 RTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEEC 3690
Score = 34.3 bits (77), Expect = 0.96
Identities = 19/47 (40%), Positives = 25/47 (53%), Gaps = 1/47 (2%)
Query: 185 AESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCN 231
A+ C+ +H C T C+ RLC+ V DC D +DE ELQ N
Sbjct: 69 AQRCQPNEHN-CLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGN 114
Score = 34.3 bits (77), Expect = 0.96
Identities = 23/64 (35%), Positives = 29/64 (45%), Gaps = 10/64 (15%)
Query: 192 DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGIC---NWEQD 242
D F C + R CI LCD +DCG+ DE N P Q + +G C +W D
Sbjct: 898 DRFKCENNR-CIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCD 956
Query: 243 AKDD 246
DD
Sbjct: 957 LDDD 960
Score = 34.3 bits (77), Expect = 0.96
Identities = 20/61 (32%), Positives = 28/61 (45%), Gaps = 10/61 (16%)
Query: 196 CRHTRACIEKLRLCDLVDDCGDRTDEVNC----APELQCNF---ETGIC---NWEQDAKD 245
C T C +CD +DCGD +DE +C P N+ +G C +W D +D
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKED 2719
Query: 246 D 246
D
Sbjct: 2720 D 2720
Score = 33.9 bits (76), Expect = 1.3
Identities = 22/79 (27%), Positives = 29/79 (36%), Gaps = 15/79 (18%)
Query: 847 FCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGE------NKCGSS---------CTFEKG 891
FC EC N +C + C+ D+CGD + E CG S C E+
Sbjct: 2733 FCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERW 2792
Query: 892 WCGWQNSQADNFDWVLGVG 910
C AD D + G
Sbjct: 2793 LCDGDKDCADGADESIAAG 2811
Score = 33.9 bits (76), Expect = 1.3
Identities = 15/37 (40%), Positives = 19/37 (51%), Gaps = 1/37 (2%)
Query: 188 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
C F C R C+ + LC+ DDCGD +DE C
Sbjct: 2904 CNASSQFLCSSGR-CVAEALLCNGQDDCGDSSDERGC 2939
Score = 33.9 bits (76), Expect = 1.3
Identities = 13/44 (29%), Positives = 22/44 (50%)
Query: 413 HNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
H C ++F C + CI + +C+ + +C D DE C C+
Sbjct: 3411 HVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCA 3454
Score = 33.9 bits (76), Expect = 1.3
Identities = 17/61 (27%), Positives = 24/61 (39%), Gaps = 3/61 (4%)
Query: 833 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGW 892
D+ EE P P C C NG+C C+ +C D + E C C ++
Sbjct: 3563 DNSDEESCTPRP---CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQ 3619
Query: 893 C 893
C
Sbjct: 3620 C 3620
Score = 33.9 bits (76), Expect = 1.3
Identities = 28/78 (35%), Positives = 35/78 (44%), Gaps = 16/78 (20%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP-----ELQCN 231
E+CT P P E F C + R CI CD DC D +DE +C P + QC
Sbjct: 3568 ESCT-PRPCSESE----FSCANGR-CIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQC- 3620
Query: 232 FETGIC---NWEQDAKDD 246
++G C W DA D
Sbjct: 3621 -KSGHCIPLRWRCDADAD 3637
Score = 33.5 bits (75), Expect = 1.6
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 3/64 (4%)
Query: 1127 CRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGS--CNFETSSGNWTTACSLTQDSE 1184
C + +C+++ L C+ DC SDE C G C T GN ++ C+ D E
Sbjct: 2573 CSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGN-SSRCNQFVDCE 2631
Query: 1185 DDLD 1188
D D
Sbjct: 2632 DASD 2635
Score = 33.5 bits (75), Expect = 1.6
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 1122 ITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
+ +F CRD CI + C+ DC SDE +C+
Sbjct: 2607 VGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCS 2640
Score = 33.5 bits (75), Expect = 1.6
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 6/69 (8%)
Query: 1123 TDFLCRDKKCIASHLL-CDYKPDCSGRSDEA-HCAHYTSTTGSCN----FETSSGNWTTA 1176
++F C + +C++S CD + DC +SDEA H TS CN F SSG
Sbjct: 2861 SEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAE 2920
Query: 1177 CSLTQDSED 1185
L +D
Sbjct: 2921 ALLCNGQDD 2929
Score = 33.5 bits (75), Expect = 1.6
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 4/54 (7%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGN 1172
C E ++F C + +CIA CD DC+ SDE C T F+ SG+
Sbjct: 3575 CSE-SEFSCANGRCIAGRWKCDGDHDCADGSDEKDC---TPRCDMDQFQCKSGH 3624
Score = 33.1 bits (74), Expect = 2.1
Identities = 16/35 (45%), Positives = 23/35 (65%), Gaps = 2/35 (5%)
Query: 415 CTDNEFICRSDGHCIEKMQ-KCDFKYDCPDKSDEA 448
C +EF C ++G C+ Q +CD + DC D+SDEA
Sbjct: 2858 CGPSEFRC-ANGRCLSSRQWECDGENDCHDQSDEA 2891
Score = 33.1 bits (74), Expect = 2.1
Identities = 27/80 (33%), Positives = 31/80 (38%), Gaps = 8/80 (10%)
Query: 1113 GEISELCPEIT----DFLCR-DKKCIASHLLCDYKPDCSGRSDE-AHCAHYTSTTGSCNF 1166
GE CPE+T F C K+CI +CD DC SDE A+C T G F
Sbjct: 3442 GEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQ--MTCGVDEF 3499
Query: 1167 ETSSGNWTTACSLTQDSEDD 1186
D EDD
Sbjct: 3500 RCKDSGRCIPARWKCDGEDD 3519
Score = 32.7 bits (73), Expect = 2.8
Identities = 24/88 (27%), Positives = 32/88 (36%), Gaps = 18/88 (20%)
Query: 178 NCT--LPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDE-------------- 221
NCT P C D F CR CI CD DC D +DE
Sbjct: 1050 NCTNQATRPPGGCH-TDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSV 1108
Query: 222 -VNCAPELQCNFETGICNWEQDAKDDFD 248
C +C + +C+ + D +D+ D
Sbjct: 1109 KFGCKDSARCISKAWVCDGDNDCEDNSD 1136
Score = 32.7 bits (73), Expect = 2.8
Identities = 14/43 (32%), Positives = 20/43 (46%)
Query: 618 DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
D P R+C C+N C++ C+ +DC D SDE
Sbjct: 2555 DEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDE 2597
Score = 32.7 bits (73), Expect = 2.8
Identities = 19/58 (32%), Positives = 26/58 (44%), Gaps = 11/58 (18%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI-----CNWEQDAKDDFD 248
C+ + C+ DDCGD +DE+ C E +C T I CN D +D D
Sbjct: 2578 CVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASD 2635
Score = 32.3 bits (72), Expect = 3.6
Identities = 27/100 (27%), Positives = 39/100 (39%), Gaps = 10/100 (10%)
Query: 617 QDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFEF 676
+DC + P +C + F C + CI CD +DC DET S + + +
Sbjct: 2686 RDCPGVKRP--RCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQN 2743
Query: 677 DLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSG 716
C KQ W S G++ AA H G + G
Sbjct: 2744 HRCISKQ-------WLCDGSDDCGDGSDEAA-HCEGKTCG 2775
Score = 31.6 bits (70), Expect = 6.2
Identities = 14/42 (33%), Positives = 21/42 (50%)
Query: 1110 LSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDE 1151
L+ ++ C +F C + +CI L CD P C +SDE
Sbjct: 2515 LTCRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDE 2556
Score = 31.6 bits (70), Expect = 6.2
Identities = 21/66 (31%), Positives = 30/66 (45%), Gaps = 3/66 (4%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC-APELQC 230
DD + +P +C G+ F CR CI C+ DC D +DE+NC A +
Sbjct: 2589 DDCGDGSDEIPCNKTAC-GVGEFRCRDG-TCIGNSSRCNQFVDCEDASDEMNCSATDCSS 2646
Query: 231 NFETGI 236
F G+
Sbjct: 2647 YFRLGV 2652
Score = 31.6 bits (70), Expect = 6.2
Identities = 23/76 (30%), Positives = 31/76 (40%), Gaps = 14/76 (18%)
Query: 191 LDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCA--------PELQCNFETGICN---W 239
+D F C+ CI CD DC D +DE C E QCN +C W
Sbjct: 3615 MDQFQCKSGH-CIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCN--NTLCKPLAW 3671
Query: 240 EQDAKDDFDWTRNQGP 255
+ D +DD ++ P
Sbjct: 3672 KCDGEDDCGDNSDENP 3687
Score = 31.2 bits (69), Expect = 8.1
Identities = 24/73 (32%), Positives = 33/73 (45%), Gaps = 14/73 (19%)
Query: 194 FWCRHTRACIEKLRLCDLVDDCGDRTDE------VNCAP-ELQCNFETGIC----NWEQD 242
F C++ R CI K +CD DC D +DE C P E +C G C WE D
Sbjct: 2823 FMCQN-RQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRC--ANGRCLSSRQWECD 2879
Query: 243 AKDDFDWTRNQGP 255
++D ++ P
Sbjct: 2880 GENDCHDQSDEAP 2892
Score = 31.2 bits (69), Expect = 8.1
Identities = 16/49 (32%), Positives = 23/49 (46%), Gaps = 7/49 (14%)
Query: 1113 GEISELCPEITDFLCRDKK-------CIASHLLCDYKPDCSGRSDEAHC 1154
G+ S+ P+ +F CR + C +CD DC SDEA+C
Sbjct: 3360 GDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANC 3408
Score = 31.2 bits (69), Expect = 8.1
Identities = 10/28 (35%), Positives = 16/28 (57%)
Query: 855 CHNGKCYRLEQSCNFVDNCGDNTGENKC 882
C N +C C++ ++CGDN+ E C
Sbjct: 3543 CKNNRCVPGRWQCDYDNDCGDNSDEESC 3570
Score = 31.2 bits (69), Expect = 8.1
Identities = 19/68 (27%), Positives = 29/68 (42%), Gaps = 9/68 (13%)
Query: 402 PETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV-----CS 456
PE PP+ F C++D C+ ++CD +C D +DE C C
Sbjct: 3687 PEECARFVCPPNR----PFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCK 3742
Query: 457 FEKRSLCK 464
+K LC+
Sbjct: 3743 DKKEFLCR 3750
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 90.1 bits (222), Expect = 1e-17
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
Query: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
Query: 1445 ADCMDFQLDESSCS 1458
DC + DE+ C+
Sbjct: 152 KDC-EGGADEAGCA 164
Score = 80.9 bits (198), Expect = 9e-15
Identities = 42/115 (36%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 1338 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C A++ SC T +CVP S +CDG +DC G+DE C LC+ EF C C+
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT-----LCAPHEFQCGNRSCLA 181
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCA--SSNSCIPAHQRCDGFADCMD 1449
++ +CDG DC DE C++ +C C +CIP CD DC D
Sbjct: 182 AVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/83 (39%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 1335 PSPCE-ADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDE 1393
P+ C A QF+C + +CV L +CDG DC D SDE DCPL C EF C
Sbjct: 256 PAACATASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLG----TCRGDEFQCGDGT 310
Query: 1394 CIPSLLLCDGVPDCHFNEDELIC 1416
C+ ++ C+ DC DE C
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGC 333
Score = 55.5 bits (132), Expect = 4e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1382 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1441
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
Query: 1442 DGFADCMDFQLDESSCSDT 1460
DG +C D DES + T
Sbjct: 106 DGEEECPDGS-DESEATCT 123
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 10/115 (8%)
Query: 1351 CVPLSGKCDGHEDCIDGSDEMD--CP-----LNPTPPLCSNM-EFPCSTDECIPSLLLCD 1402
C+P CD DC D SDE C P C+ +F C + EC+ CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 1403 GVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
G DC DE C +C C +C+ A + C+ DC D DE+ C
Sbjct: 281 GDRDCKDKSDEADCPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGS-DEAGC 333
Score = 46.2 bits (108), Expect = 2e-04
Identities = 24/57 (42%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 399 PTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
P P TS P T ++F CRS G C+ +CD DC DKSDEA C + C
Sbjct: 248 PGPGATSAPAAC----ATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
Query: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
+ S G + SW+ + ++D
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
E C+ E++ D D T+ P L+ GP
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
Score = 42.4 bits (98), Expect = 0.004
Identities = 16/32 (50%), Positives = 20/32 (62%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C HEF C N+ C+A +CD +DC D SDE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE 198
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/41 (43%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
P C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 295 PLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
Score = 40.0 bits (92), Expect = 0.017
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
Query: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
+G C E C ++E + D
Sbjct: 94 DNGHCIHERWKCDGEEECPDGSD 116
Score = 38.9 bits (89), Expect = 0.039
Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 5/75 (6%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA-- 1176
C + F CR +C+ CD DC +SDEA C T F+ G A
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIK 316
Query: 1177 -CSLTQDSEDDLDWA 1190
C+ QD D D A
Sbjct: 317 HCNQEQDCPDGSDEA 331
Score = 37.4 bits (85), Expect = 0.11
Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 5/43 (11%)
Query: 415 CTDNEFICRSDGH--CIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C EF C DG CI + CD ++DC D+SDEA+ E+C
Sbjct: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAA---ELC 245
Score = 35.8 bits (81), Expect = 0.33
Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 12/73 (16%)
Query: 187 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI---- 236
+C F CR + C+ CD DC D++DE +C E QC T +
Sbjct: 258 ACATASQFACR-SGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIK 316
Query: 237 -CNWEQDAKDDFD 248
CN EQD D D
Sbjct: 317 HCNQEQDCPDGSD 329
Score = 35.4 bits (80), Expect = 0.43
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 14/63 (22%)
Query: 200 RACIEKLRLCDLVDDCGDRTDEVNCAP------ELQCNFETG--------ICNWEQDAKD 245
R+C+ + +CD DDCGD +DE CA E +C + G +C+ + D +D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 246 DFD 248
D
Sbjct: 237 RSD 239
Score = 35.0 bits (79), Expect = 0.56
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Score = 34.3 bits (77), Expect = 0.96
Identities = 13/32 (40%), Positives = 19/32 (59%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
+F C ++ C+A+ +CD DC SDE CA
Sbjct: 171 EFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 33.5 bits (75), Expect = 1.6
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 672
P C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 295 PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 347
Score = 32.0 bits (71), Expect = 4.8
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 8/50 (16%)
Query: 624 SPERKCTD-----HEFMCANKH---CIAKDKLCDFVNDCADNSDETTFIC 665
S ER C D EF C CI + +CD DC D SDE +C
Sbjct: 196 SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 31.6 bits (70), Expect = 6.2
Identities = 12/25 (48%), Positives = 16/25 (64%)
Query: 1131 KCIASHLLCDYKPDCSGRSDEAHCA 1155
KC+ + CD + DC G +DEA CA
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCA 164
Score = 31.6 bits (70), Expect = 6.2
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C +EF C + C+ + CD DC D SDE C C
Sbjct: 167 CAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPAC 206
Score = 31.6 bits (70), Expect = 6.2
Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-QCNFETGICN 238
P +C G D F C C+ ++ C+ DC D +DE C L +C G C+
Sbjct: 295 PLGTCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 348
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 90.1 bits (222), Expect = 1e-17
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
Query: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
Query: 1445 ADCMDFQLDESSCS 1458
DC + DE+ C+
Sbjct: 152 KDC-EGGADEAGCA 164
Score = 55.5 bits (132), Expect = 4e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1382 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1441
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
Query: 1442 DGFADCMDFQLDESSCSDT 1460
DG +C D DES + T
Sbjct: 106 DGEEECPDGS-DESEATCT 123
Score = 55.5 bits (132), Expect = 4e-07
Identities = 29/80 (36%), Positives = 40/80 (50%), Gaps = 3/80 (3%)
Query: 1338 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C A++ SC T +CVP S +CDG +DC G+DE C + C EF C C+
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGT--CRGDEFQCGDGTCVL 184
Query: 1397 SLLLCDGVPDCHFNEDELIC 1416
++ C+ DC DE C
Sbjct: 185 AIKHCNQEQDCPDGSDEAGC 204
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
Query: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
+ S G + SW+ + ++D
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
E C+ E++ D D T+ P L+ GP
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
Score = 40.8 bits (94), Expect = 0.010
Identities = 17/37 (45%), Positives = 24/37 (64%), Gaps = 1/37 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 170 CRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 205
Score = 40.0 bits (92), Expect = 0.017
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
Query: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
+G C E C ++E + D
Sbjct: 94 DNGHCIHERWKCDGEEECPDGSD 116
Score = 39.3 bits (90), Expect = 0.030
Identities = 22/63 (34%), Positives = 28/63 (44%), Gaps = 3/63 (4%)
Query: 1131 KCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA---CSLTQDSEDDL 1187
KC+ + CD + DC G +DEA CA T F+ G A C+ QD D
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGS 199
Query: 1188 DWA 1190
D A
Sbjct: 200 DEA 202
Score = 35.0 bits (79), Expect = 0.56
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Score = 33.1 bits (74), Expect = 2.1
Identities = 16/49 (32%), Positives = 22/49 (44%), Gaps = 5/49 (10%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 672
C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 170 CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 90.1 bits (222), Expect = 1e-17
Identities = 50/134 (37%), Positives = 69/134 (51%), Gaps = 11/134 (8%)
Query: 1328 GGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEF 1387
GG P + CE DQF C +C+P +CD +DC+D SDE DCP C++ +F
Sbjct: 39 GGQGPAKD--CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCP----KKTCADSDF 91
Query: 1388 PCSTDECIPSLLLCDGVPDC--HFNEDELICSNKSCSNGALVCA-SSNSCIPAHQRCDGF 1444
C CI CDG +C +E E C+ + C L C +S+ C+PA RCDG
Sbjct: 92 TCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGE 151
Query: 1445 ADCMDFQLDESSCS 1458
DC + DE+ C+
Sbjct: 152 KDC-EGGADEAGCA 164
Score = 80.9 bits (198), Expect = 9e-15
Identities = 42/115 (36%), Positives = 57/115 (49%), Gaps = 8/115 (6%)
Query: 1338 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C A++ SC T +CVP S +CDG +DC G+DE C LC+ EF C C+
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCAT-----LCAPHEFQCGNRSCLA 181
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCA--SSNSCIPAHQRCDGFADCMD 1449
++ +CDG DC DE C++ +C C +CIP CD DC D
Sbjct: 182 AVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/83 (39%), Positives = 42/83 (50%), Gaps = 6/83 (7%)
Query: 1335 PSPCE-ADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDE 1393
P+ C A QF+C + +CV L +CDG DC D SDE DCPL C EF C
Sbjct: 256 PAACATASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLG----TCRGDEFQCGDGT 310
Query: 1394 CIPSLLLCDGVPDCHFNEDELIC 1416
C+ ++ C+ DC DE C
Sbjct: 311 CVLAIKHCNQEQDCPDGSDEAGC 333
Score = 55.5 bits (132), Expect = 4e-07
Identities = 28/79 (35%), Positives = 39/79 (49%), Gaps = 2/79 (2%)
Query: 1382 CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRC 1441
C +F C + CIPS+ CD DC + DE C K+C++ C + CI +C
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-DNGHCIHERWKC 105
Query: 1442 DGFADCMDFQLDESSCSDT 1460
DG +C D DES + T
Sbjct: 106 DGEEECPDGS-DESEATCT 123
Score = 53.9 bits (128), Expect = 1e-06
Identities = 25/53 (47%), Positives = 33/53 (62%), Gaps = 3/53 (5%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSD--EASCVMEVCSFEKRS 461
P C D++F C +GHCI + KCD + +CPD SD EA+C +VC EK S
Sbjct: 82 PKKTCADSDFTC-DNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLS 133
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 10/115 (8%)
Query: 1351 CVPLSGKCDGHEDCIDGSDEMD--CP-----LNPTPPLCSNM-EFPCSTDECIPSLLLCD 1402
C+P CD DC D SDE C P C+ +F C + EC+ CD
Sbjct: 221 CIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCD 280
Query: 1403 GVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
G DC DE C +C C +C+ A + C+ DC D DE+ C
Sbjct: 281 GDRDCKDKSDEADCPLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGS-DEAGC 333
Score = 46.2 bits (108), Expect = 2e-04
Identities = 24/57 (42%), Positives = 29/57 (50%), Gaps = 5/57 (8%)
Query: 399 PTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
P P TS P T ++F CRS G C+ +CD DC DKSDEA C + C
Sbjct: 248 PGPGATSAPAAC----ATASQFACRS-GECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 45.8 bits (107), Expect = 3e-04
Identities = 26/89 (29%), Positives = 39/89 (43%), Gaps = 13/89 (14%)
Query: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-- 665
D +D DC P++ C D +F C N HCI + CD +C D SDE+ C
Sbjct: 70 DDCLDHSDEDDC-----PKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTK 124
Query: 666 ------RTSSGRCDFEFDLCSWKQEKDED 688
+ S G + SW+ + ++D
Sbjct: 125 QVCPAEKLSCGPTSHKCVPASWRCDGEKD 153
Score = 42.7 bits (99), Expect = 0.003
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 18/96 (18%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-----------QCNF 232
PA+ CE D F CR+ R CI + CD DDC D +DE +C + C
Sbjct: 43 PAKDCEK-DQFQCRNER-CIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 233 ETGICNWEQDAKDDFD-----WTRNQGPTPTLNTGP 263
E C+ E++ D D T+ P L+ GP
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP 136
Score = 42.4 bits (98), Expect = 0.004
Identities = 16/32 (50%), Positives = 20/32 (62%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C HEF C N+ C+A +CD +DC D SDE
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE 198
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/41 (43%), Positives = 25/41 (60%), Gaps = 1/41 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
P C +EF C DG C+ ++ C+ + DCPD SDEA C+
Sbjct: 295 PLGTCRGDEFQC-GDGTCVLAIKHCNQEQDCPDGSDEAGCL 334
Score = 40.0 bits (92), Expect = 0.017
Identities = 17/46 (36%), Positives = 26/46 (56%), Gaps = 1/46 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P +C ++F CR++ CI + +CD DC D SDE C + C+
Sbjct: 43 PAKDCEKDQFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCA 87
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 15/83 (18%)
Query: 621 PLLS---PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE----------TTFICRT 667
PLL P + C +F C N+ CI CD +DC D+SDE + F C
Sbjct: 36 PLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTC-- 93
Query: 668 SSGRCDFEFDLCSWKQEKDEDFD 690
+G C E C ++E + D
Sbjct: 94 DNGHCIHERWKCDGEEECPDGSD 116
Score = 38.9 bits (89), Expect = 0.039
Identities = 24/75 (32%), Positives = 30/75 (40%), Gaps = 5/75 (6%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTA-- 1176
C + F CR +C+ CD DC +SDEA C T F+ G A
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCP--LGTCRGDEFQCGDGTCVLAIK 316
Query: 1177 -CSLTQDSEDDLDWA 1190
C+ QD D D A
Sbjct: 317 HCNQEQDCPDGSDEA 331
Score = 37.4 bits (85), Expect = 0.11
Identities = 19/43 (44%), Positives = 25/43 (58%), Gaps = 5/43 (11%)
Query: 415 CTDNEFICRSDGH--CIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C EF C DG CI + CD ++DC D+SDEA+ E+C
Sbjct: 206 CGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAA---ELC 245
Score = 35.8 bits (81), Expect = 0.33
Identities = 24/73 (32%), Positives = 31/73 (42%), Gaps = 12/73 (16%)
Query: 187 SCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI---- 236
+C F CR + C+ CD DC D++DE +C E QC T +
Sbjct: 258 ACATASQFACR-SGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIK 316
Query: 237 -CNWEQDAKDDFD 248
CN EQD D D
Sbjct: 317 HCNQEQDCPDGSD 329
Score = 35.4 bits (80), Expect = 0.43
Identities = 20/63 (31%), Positives = 31/63 (49%), Gaps = 14/63 (22%)
Query: 200 RACIEKLRLCDLVDDCGDRTDEVNCAP------ELQCNFETG--------ICNWEQDAKD 245
R+C+ + +CD DDCGD +DE CA E +C + G +C+ + D +D
Sbjct: 177 RSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCED 236
Query: 246 DFD 248
D
Sbjct: 237 RSD 239
Score = 35.0 bits (79), Expect = 0.56
Identities = 19/54 (35%), Positives = 24/54 (44%), Gaps = 7/54 (12%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-------AHYTSTTGSCNFE 1167
E F CR+++CI S CD DC SDE C + +T G C E
Sbjct: 48 EKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHE 101
Score = 34.3 bits (77), Expect = 0.96
Identities = 13/32 (40%), Positives = 19/32 (59%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
+F C ++ C+A+ +CD DC SDE CA
Sbjct: 171 EFQCGNRSCLAAVFVCDGDDDCGDGSDERGCA 202
Score = 33.5 bits (75), Expect = 1.6
Identities = 17/53 (32%), Positives = 23/53 (43%), Gaps = 5/53 (9%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-----CRTSSGRC 672
P C EF C + C+ K C+ DC D SDE + C ++G C
Sbjct: 295 PLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 347
Score = 32.0 bits (71), Expect = 4.8
Identities = 19/50 (38%), Positives = 22/50 (44%), Gaps = 8/50 (16%)
Query: 624 SPERKCTD-----HEFMCANKH---CIAKDKLCDFVNDCADNSDETTFIC 665
S ER C D EF C CI + +CD DC D SDE +C
Sbjct: 196 SDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELC 245
Score = 31.6 bits (70), Expect = 6.2
Identities = 12/25 (48%), Positives = 16/25 (64%)
Query: 1131 KCIASHLLCDYKPDCSGRSDEAHCA 1155
KC+ + CD + DC G +DEA CA
Sbjct: 140 KCVPASWRCDGEKDCEGGADEAGCA 164
Score = 31.6 bits (70), Expect = 6.2
Identities = 15/41 (36%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C +EF C + C+ + CD DC D SDE C C
Sbjct: 167 CAPHEFQC-GNRSCLAAVFVCDGDDDCGDGSDERGCADPAC 206
Score = 31.6 bits (70), Expect = 6.2
Identities = 18/56 (32%), Positives = 26/56 (46%), Gaps = 3/56 (5%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPEL-QCNFETGICN 238
P +C G D F C C+ ++ C+ DC D +DE C L +C G C+
Sbjct: 295 PLGTCRG-DEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCS 348
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 88.6 bits (218), Expect = 4e-17
Identities = 51/122 (41%), Positives = 63/122 (51%), Gaps = 4/122 (3%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C +F C C+ CDG DC DGSDE +CP P C+ EF C+ CI
Sbjct: 148 CSDKEFRCSDG-SCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILD 206
Query: 1398 LLLCDGVPDCHFNEDELIC-SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESS 1456
+ CDG DC DE C S++ C +G +C S CI A RCDG ADC D Q DE +
Sbjct: 207 IYHCDGDDDCGDWSDESDCSSHQPCRSGEFMC-DSGLCINAGWRCDGDADC-DDQSDERN 264
Query: 1457 CS 1458
C+
Sbjct: 265 CT 266
Score = 85.1 bits (209), Expect = 5e-16
Identities = 54/154 (35%), Positives = 70/154 (45%), Gaps = 14/154 (9%)
Query: 1307 DGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCID 1366
DG+ D D S C + P P PC ++F C Y +C+ CDG +DC D
Sbjct: 168 DGDTDC----KDGSDEENCPSAVPAP----PCNLEEFQCAYG-RCILDIYHCDGDDDCGD 218
Query: 1367 GSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGAL 1426
SDE DC + C + EF C + CI + CDG DC DE C+ C+
Sbjct: 219 WSDESDCSSHQP---CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQF 275
Query: 1427 VCASSNSCIPAHQRCDGFADCMDFQLDESSCSDT 1460
C S C+ RCDG DC D DE +C +T
Sbjct: 276 RC-HSGRCVRLSWRCDGEDDCAD-NSDEENCENT 307
Score = 81.6 bits (200), Expect = 5e-15
Identities = 49/148 (33%), Positives = 64/148 (43%), Gaps = 23/148 (15%)
Query: 1319 ISFTPECVTGGPVPVQPSPCEADQFSCIYTL----QCVPLSGKCDGHEDCIDGSDEMDCP 1374
++ +PEC C F+C + C+P +CDG DC D SDE C
Sbjct: 19 LASSPECA-----------CGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCI 67
Query: 1375 LNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSC 1434
L P CS ++F C +CI +CDG DC + DE C + C C + C
Sbjct: 68 L----PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYC 122
Query: 1435 IPAHQRCDGFADC---MDFQLDESSCSD 1459
I + CDG DC D Q D CSD
Sbjct: 123 IRSLWHCDGDNDCGDNSDEQCDMRKCSD 150
Score = 78.2 bits (191), Expect = 6e-14
Identities = 89/341 (26%), Positives = 123/341 (36%), Gaps = 54/341 (15%)
Query: 1124 DFLCRDKKCIASHLLCDYKPDCSGRSDEAHC--------------AHYTSTTGSCNFETS 1169
DF C + KCI +CD DC SDE C + + C+ +
Sbjct: 75 DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDND 134
Query: 1170 SG-NWTTACSLTQDSEDDLDWAIGSRIPAKALIP-DSDHTPGSGQHFLYVNSSGSKEGSV 1227
G N C + + S+ + + GS I D+D GS +
Sbjct: 135 CGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGS-------DEENCPSAVP 187
Query: 1228 ARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIGNKRTGWTY 1287
A + F + G C IL +Y + + WS + +
Sbjct: 188 APPCNLEEFQCAYGRC---------------ILDIYHCDGDD-DCGDWSDESDCSSHQPC 231
Query: 1288 GSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCEADQFSCIY 1347
S +S + DG+ D DD S C T S C A+QF C +
Sbjct: 232 RSGEFMCDSGLCINAGWRCDGDAD----CDDQSDERNCTT--------SMCTAEQFRC-H 278
Query: 1348 TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDC 1407
+ +CV LS +CDG +DC D SDE +C N P C+ +F C CI LC+GV DC
Sbjct: 279 SGRCVRLSWRCDGEDDCADNSDEENCE-NTGSPQCALDQFLCWNGRCIGQRKLCNGVNDC 337
Query: 1408 HFNEDELICSNKSCSNGALVCASSN-SCIPAHQRCDGFADC 1447
N DE N G C +N C Q G C
Sbjct: 338 GDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQC 378
Score = 52.0 bits (123), Expect = 4e-06
Identities = 34/96 (35%), Positives = 42/96 (43%), Gaps = 12/96 (12%)
Query: 612 DDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI------- 664
DD QDC P R+C + EF C N +CI CD NDC DNSDE +
Sbjct: 98 DDSDEQDCPP-----RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKE 152
Query: 665 CRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPA 700
R S G C E C + + D S++PA
Sbjct: 153 FRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPA 188
Score = 49.3 bits (116), Expect = 3e-05
Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 5/78 (6%)
Query: 608 DVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET-TFICR 666
D D+ ++C SP+ C +F+C N CI + KLC+ VNDC DNSDE+ CR
Sbjct: 293 DDCADNSDEENCENTGSPQ--CALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
Query: 667 TSSG--RCDFEFDLCSWK 682
+G C+ C+ K
Sbjct: 351 PRTGEENCNVNNGGCAQK 368
Score = 48.1 bits (113), Expect = 6e-05
Identities = 29/80 (36%), Positives = 39/80 (48%), Gaps = 10/80 (12%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCN----- 231
ENC +PA C L+ F C + R CI + CD DDCGD +DE +C+ C
Sbjct: 180 ENCPSAVPAPPCN-LEEFQCAYGR-CILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFM 237
Query: 232 FETGIC---NWEQDAKDDFD 248
++G+C W D D D
Sbjct: 238 CDSGLCINAGWRCDGDADCD 257
Score = 47.0 bits (110), Expect = 1e-04
Identities = 27/69 (39%), Positives = 35/69 (50%), Gaps = 3/69 (4%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIP 470
PP C ++EF C++ G+CI + CD DC D SDE C M CS +K C I
Sbjct: 106 PPRECEEDEFPCQN-GYCIRSLWHCDGDNDCGDNSDE-QCDMRKCS-DKEFRCSDGSCIA 162
Query: 471 VHLLQDSNT 479
H D +T
Sbjct: 163 EHWYCDGDT 171
Score = 46.6 bits (109), Expect = 2e-04
Identities = 26/75 (34%), Positives = 35/75 (46%), Gaps = 5/75 (6%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICR 666
GD D S + C RKC+D EF C++ CIA+ CD DC D SDE
Sbjct: 131 GDNDCGDNSDEQCDM-----RKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSA 185
Query: 667 TSSGRCDFEFDLCSW 681
+ C+ E C++
Sbjct: 186 VPAPPCNLEEFQCAY 200
Score = 43.5 bits (101), Expect = 0.002
Identities = 29/89 (32%), Positives = 37/89 (41%), Gaps = 5/89 (5%)
Query: 607 GDVAVDDISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFI-- 664
GD D S ++ P P C EF CA CI CD +DC D SDE+
Sbjct: 169 GDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSH 228
Query: 665 --CRTSSGRCDFEFDL-CSWKQEKDEDFD 690
CR+ CD + W+ + D D D
Sbjct: 229 QPCRSGEFMCDSGLCINAGWRCDGDADCD 257
Score = 43.5 bits (101), Expect = 0.002
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 21/112 (18%)
Query: 607 GDVAVDDISFQ-DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT--- 662
GD DD S + +C+ + CT +F C + C+ CD +DCADNSDE
Sbjct: 252 GDADCDDQSDERNCTTSM-----CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCEN 306
Query: 663 ----------FICRTSSGRCDFEFDLCSWKQEKDEDFDWNLKASSIPAAGTE 704
F+C +GRC + LC+ + ++ D + + + P G E
Sbjct: 307 TGSPQCALDQFLC--WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEE 356
Score = 42.7 bits (99), Expect = 0.003
Identities = 19/45 (42%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEK 459
C EF+C S G CI +CD DC D+SDE +C +C+ E+
Sbjct: 231 CRSGEFMCDS-GLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQ 274
Score = 41.2 bits (95), Expect = 0.008
Identities = 22/49 (44%), Positives = 27/49 (55%), Gaps = 5/49 (10%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV----CSFEK 459
C+D EF C SDG CI + CD DC D SDE +C V C+ E+
Sbjct: 148 CSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEE 195
Score = 41.2 bits (95), Expect = 0.008
Identities = 21/76 (27%), Positives = 30/76 (39%), Gaps = 16/76 (21%)
Query: 845 TGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSS----------------CTF 888
T C CH+G+C RL C+ D+C DN+ E C ++ C
Sbjct: 267 TSMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIG 326
Query: 889 EKGWCGWQNSQADNFD 904
++ C N DN D
Sbjct: 327 QRKLCNGVNDCGDNSD 342
Score = 39.7 bits (91), Expect = 0.023
Identities = 27/73 (36%), Positives = 34/73 (46%), Gaps = 12/73 (16%)
Query: 624 SPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---TTFIC-----RTSSGRCDFE 675
S + C EFMC + CI CD DC D SDE TT +C R SGRC
Sbjct: 226 SSHQPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRC--- 282
Query: 676 FDLCSWKQEKDED 688
SW+ + ++D
Sbjct: 283 -VRLSWRCDGEDD 294
Score = 38.1 bits (87), Expect = 0.066
Identities = 35/123 (28%), Positives = 49/123 (39%), Gaps = 21/123 (17%)
Query: 166 DGVSAIDDIRFE-NCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC 224
DG + DD E NCT + C + F C H+ C+ CD DDC D +DE NC
Sbjct: 251 DGDADCDDQSDERNCTTSM----CTA-EQFRC-HSGRCVRLSWRCDGEDDCADNSDEENC 304
Query: 225 ----APEL----------QCNFETGICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLG 270
+P+ +C + +CN D D+ D + Q P N G
Sbjct: 305 ENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGG 364
Query: 271 TAK 273
A+
Sbjct: 365 CAQ 367
Score = 38.1 bits (87), Expect = 0.066
Identities = 16/36 (44%), Positives = 21/36 (58%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
CT +F C S G C+ +CD + DC D SDE +C
Sbjct: 270 CTAEQFRCHS-GRCVRLSWRCDGEDDCADNSDEENC 304
Score = 37.4 bits (85), Expect = 0.11
Identities = 15/32 (46%), Positives = 20/32 (62%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C+ +F C N CI + +CD NDC D+SDE
Sbjct: 71 CSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE 102
Score = 36.6 bits (83), Expect = 0.19
Identities = 19/48 (39%), Positives = 24/48 (50%), Gaps = 1/48 (2%)
Query: 403 ETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
E + P +P C EF C + G CI + CD DC D SDE+ C
Sbjct: 179 EENCPSAVPAPPCNLEEFQC-AYGRCILDIYHCDGDDDCGDWSDESDC 225
Score = 36.6 bits (83), Expect = 0.19
Identities = 17/60 (28%), Positives = 27/60 (45%)
Query: 1122 ITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACSLTQ 1181
+ FLC + +CI LC+ DC SDE+ + TG N ++G C + +
Sbjct: 314 LDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVR 373
Score = 35.8 bits (81), Expect = 0.33
Identities = 26/80 (32%), Positives = 32/80 (40%), Gaps = 13/80 (16%)
Query: 624 SPERKCTDHEFMCANKH-----CIAKDKLCDFVNDCADNSDETTFICRTSS--------G 670
SPE C F CA CI CD NDC D+SDE I T S G
Sbjct: 22 SPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNG 81
Query: 671 RCDFEFDLCSWKQEKDEDFD 690
+C +C + ++D D
Sbjct: 82 KCIRRSWVCDGDNDCEDDSD 101
Score = 35.4 bits (80), Expect = 0.43
Identities = 17/48 (35%), Positives = 25/48 (52%)
Query: 833 DSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCGDNTGEN 880
D+ EE + C L C NG+C + CN V++CGDN+ E+
Sbjct: 297 DNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDES 344
Score = 34.7 bits (78), Expect = 0.73
Identities = 17/50 (34%), Positives = 22/50 (44%), Gaps = 4/50 (8%)
Query: 411 PPHNCTDNEFICR----SDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P C + F C + CI +CD DC D SDE C++ CS
Sbjct: 23 PECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCS 72
Score = 34.7 bits (78), Expect = 0.73
Identities = 16/41 (39%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C+ +F C +G CI + CD DC D SDE C C
Sbjct: 71 CSPLDFHC-DNGKCIRRSWVCDGDNDCEDDSDEQDCPPREC 110
Score = 34.3 bits (77), Expect = 0.96
Identities = 26/79 (32%), Positives = 37/79 (46%), Gaps = 17/79 (21%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP------ELQC 230
+ C LP +C LD F C + + CI + +CD +DC D +DE +C P E C
Sbjct: 64 DGCILP----TCSPLD-FHCDNGK-CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC 117
Query: 231 NFETGIC---NWEQDAKDD 246
+ G C W D +D
Sbjct: 118 --QNGYCIRSLWHCDGDND 134
Score = 34.3 bits (77), Expect = 0.96
Identities = 29/87 (33%), Positives = 40/87 (45%), Gaps = 16/87 (18%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEV----NCA-P 226
DD ++C P CE D F C++ CI L CD +DCGD +DE C+
Sbjct: 98 DDSDEQDC----PPRECEE-DEFPCQNGY-CIRSLWHCDGDNDCGDNSDEQCDMRKCSDK 151
Query: 227 ELQCN-----FETGICNWEQDAKDDFD 248
E +C+ E C+ + D KD D
Sbjct: 152 EFRCSDGSCIAEHWYCDGDTDCKDGSD 178
Score = 33.9 bits (76), Expect = 1.3
Identities = 21/74 (28%), Positives = 30/74 (40%), Gaps = 15/74 (20%)
Query: 190 GLDHFWCRHTR----ACIEKLRLCDLVDDCGDRTDEVNC-----------APELQCNFET 234
G HF C + CI CD +DCGD +DE C +C +
Sbjct: 28 GRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRS 87
Query: 235 GICNWEQDAKDDFD 248
+C+ + D +DD D
Sbjct: 88 WVCDGDNDCEDDSD 101
Score = 32.3 bits (72), Expect = 3.6
Identities = 24/70 (34%), Positives = 30/70 (42%), Gaps = 11/70 (15%)
Query: 815 GDIALDDIVLTENCLSLHDSVQEELAVPLPTGFCPLGYRECHNGKCYRLEQSCNFVDNCG 874
GD D ENC S AVP P C L +C G+C C+ D+CG
Sbjct: 169 GDTDCKDGSDEENCPS---------AVPAPP--CNLEEFQCAYGRCILDIYHCDGDDDCG 217
Query: 875 DNTGENKCGS 884
D + E+ C S
Sbjct: 218 DWSDESDCSS 227
Score = 32.3 bits (72), Expect = 3.6
Identities = 32/106 (30%), Positives = 44/106 (41%), Gaps = 15/106 (14%)
Query: 151 QPFHLSLDKVSLGIY--DGVSAIDDIRFEN-CTLPLPAESCEGLDHFWCRHTRACIEKLR 207
+ F + + L IY DG D E+ C+ P S E F C + CI
Sbjct: 194 EEFQCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGE----FMC-DSGLCINAGW 248
Query: 208 LCDLVDDCGDRTDEVNCAPEL----QCNFETGIC---NWEQDAKDD 246
CD DC D++DE NC + Q +G C +W D +DD
Sbjct: 249 RCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWRCDGEDD 294
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 87.0 bits (214), Expect = 1e-16
Identities = 45/128 (35%), Positives = 66/128 (51%), Gaps = 10/128 (7%)
Query: 1334 QPSPCEADQFSCIY-TLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTD 1392
+P C QF+C + C+P++ +CDG +C D SDE++C P+CS +F C++
Sbjct: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------PVCSESQFQCASG 1298
Query: 1393 ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQL 1452
+CI L C+G +C DE C C CA + CI H++CD DC D +
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCA-NGQCIGKHKKCDHNVDCSD-KS 1355
Query: 1453 DESSCSDT 1460
DE C T
Sbjct: 1356 DELDCYPT 1363
Score = 43.5 bits (101), Expect = 0.002
Identities = 22/48 (45%), Positives = 26/48 (54%)
Query: 613 DISFQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
D + QD S + E C +F CAN CI K K CD DC+D SDE
Sbjct: 1310 DANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDE 1357
Score = 42.0 bits (97), Expect = 0.005
Identities = 18/36 (50%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
C ++F C ++G CI K +KCD DC DKSDE C
Sbjct: 1326 CLIDQFRC-ANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 38.9 bits (89), Expect = 0.039
Identities = 15/33 (45%), Positives = 19/33 (57%)
Query: 1122 ITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
I F C + +CI H CD+ DCS +SDE C
Sbjct: 1328 IDQFRCANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 37.7 bits (86), Expect = 0.087
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 8/99 (8%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT--FICRTSSGRCDFEFDLCSWKQEK- 685
C++ +F CA+ CI C+ +C D SDE +C RC C K +K
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRC--ANGQCIGKHKKC 1345
Query: 686 DEDFDWNLKASSIPAAGTE---PAADHTLGNSSGHYIFI 721
D + D + K+ + TE P A +T+G+ G + I
Sbjct: 1346 DHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGVIVTI 1384
Score = 37.7 bits (86), Expect = 0.087
Identities = 23/64 (35%), Positives = 33/64 (51%), Gaps = 3/64 (4%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474
C++++F C S G CI+ +C+ +C DKSDE +C EV + C Q I H
Sbjct: 1288 CSESQFQCAS-GQCIDGALRCNGDANCQDKSDEKNC--EVLCLIDQFRCANGQCIGKHKK 1344
Query: 475 QDSN 478
D N
Sbjct: 1345 CDHN 1348
Score = 36.6 bits (83), Expect = 0.19
Identities = 20/52 (38%), Positives = 29/52 (55%), Gaps = 4/52 (7%)
Query: 178 NCTLPLPAESCEGL---DHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAP 226
NC ++CE L D F C + + CI K + CD DC D++DE++C P
Sbjct: 1312 NCQDKSDEKNCEVLCLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDCYP 1362
Score = 34.7 bits (78), Expect = 0.73
Identities = 26/100 (26%), Positives = 40/100 (40%), Gaps = 16/100 (16%)
Query: 1119 CPEITD--FLCRDKKCIASHLLCDYKPDCSGRSDEAHCA------HYTSTTGSCNFETSS 1170
CP ++ F C +CI L C+ +C +SDE +C + G C +
Sbjct: 1285 CPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKK 1344
Query: 1171 GNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGS 1210
+ CS D D+LD P + P + +T GS
Sbjct: 1345 CDHNVDCS---DKSDELDC-----YPTEEPAPQATNTVGS 1376
Score = 32.3 bits (72), Expect = 3.6
Identities = 17/46 (36%), Positives = 23/46 (50%), Gaps = 3/46 (6%)
Query: 412 PHNCTDNEFIC-RSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
P C+ +F C + CI +CD +C D SDE +C VCS
Sbjct: 1246 PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCS 1289
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 84.7 bits (208), Expect = 6e-16
Identities = 49/136 (36%), Positives = 63/136 (46%), Gaps = 20/136 (14%)
Query: 1338 CEADQFSCIYTL-QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIP 1396
C++ FSC + +C+P +CDG DC +GSDE CP P CS EF C +CI
Sbjct: 68 CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP----PKTCSQDEFRCHDGKCIS 123
Query: 1397 SLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMD------- 1449
+CD DC DE C +C + C +S++CIP CD DC D
Sbjct: 124 RQFVCDSDRDCLDGSDEASCPVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQ 182
Query: 1450 -------FQLDESSCS 1458
FQ D S CS
Sbjct: 183 RCRGLYVFQGDSSPCS 198
Score = 75.5 bits (184), Expect = 4e-13
Identities = 49/168 (29%), Positives = 61/168 (36%), Gaps = 48/168 (28%)
Query: 1335 PSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPL------------- 1381
P C D+F C + +C+ CD DC+DGSDE CP+ P
Sbjct: 106 PKTCSQDEFRC-HDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQL 164
Query: 1382 --------------------------------CSNMEFPCSTDECIPSLLLCDGVPDCHF 1409
CS EF C + ECI S CDG PDC
Sbjct: 165 WACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKD 224
Query: 1410 NEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
DE C+ +C C+ N CI ++CD DC D DE C
Sbjct: 225 KSDEENCAVATCRPDEFQCSDGN-CIHGSRQCDREYDCKDMS-DEVGC 270
Score = 73.6 bits (179), Expect = 1e-12
Identities = 45/123 (36%), Positives = 58/123 (47%), Gaps = 9/123 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDE-MDCPLNPTPPLCSNMEFPCS--TDEC 1394
CE ++F C +C+ CDG +C DGSDE + L+ T C + +F C + C
Sbjct: 27 CERNEFQC-QDGKCISYKWVCDGSAECQDGSDESQETCLSVT---CKSGDFSCGGRVNRC 82
Query: 1395 IPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDE 1454
IP CDG DC DE C K+CS C CI CD DC+D DE
Sbjct: 83 IPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRC-HDGKCISRQFVCDSDRDCLDGS-DE 140
Query: 1455 SSC 1457
+SC
Sbjct: 141 ASC 143
Score = 68.9 bits (167), Expect = 4e-11
Identities = 41/116 (35%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 1336 SPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECI 1395
SPC A +F C+ + +C+ S +CDG DC D SDE +C + C EF CS CI
Sbjct: 195 SPCSAFEFHCL-SGECIHSSWRCDGGPDCKDKSDEENCAV----ATCRPDEFQCSDGNCI 249
Query: 1396 PSLLLCDGVPDCHFNEDELICSNKS-CSNGALVCASSNSCIPAHQRCDGFADCMDF 1450
CD DC DE+ C N + C S CI + C+ DC D+
Sbjct: 250 HGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW 305
Score = 55.8 bits (133), Expect = 3e-07
Identities = 90/367 (24%), Positives = 128/367 (34%), Gaps = 72/367 (19%)
Query: 1121 EITDFLCRDKKCIASHLLCDYKPDCSGRSDEAH--CAHYTSTTG--SCN----------- 1165
E +F C+D KCI+ +CD +C SDE+ C T +G SC
Sbjct: 28 ERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFW 87
Query: 1166 -----FETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSS 1220
+ +G+ C S+D+ G I ++ + DSD
Sbjct: 88 RCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCI-SRQFVCDSDRDC----------LD 136
Query: 1221 GSKEGSVARITTSK-SFPASLGMCTVRFWFYMIDPRSMGILKVYTIEESGLNILVWSVIG 1279
GS E S +T SF + C + W DP + GL + G
Sbjct: 137 GSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQ----G 192
Query: 1280 NKRTGWTYGSVPLSSNSPFKVAFEADLDGNEDIFIALDDISFTPECVTGGPVPVQPSPCE 1339
+ + LS + DG D D S C + C
Sbjct: 193 DSSPCSAFEFHCLSGEC---IHSSWRCDGGPDC----KDKSDEENCAV--------ATCR 237
Query: 1340 ADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNM-EFPCSTDECIPSL 1398
D+F C C+ S +CD DC D SDE+ C +N T LC +F C + ECI
Sbjct: 238 PDEFQCSDG-NCIHGSRQCDREYDCKDMSDEVGC-VNVT--LCEGPNKFKCHSGECITLD 293
Query: 1399 LLCDGVPDCHFNEDELI--CSNKSC--SNGAL--VC----------ASSNSCIPAHQRCD 1442
+C+ DC DE I C C +NG VC + A +RC+
Sbjct: 294 KVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCE 353
Query: 1443 GFADCMD 1449
+C D
Sbjct: 354 DIDECQD 360
Score = 48.1 bits (113), Expect = 6e-05
Identities = 22/45 (48%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
PP C+ +EF C DG CI + CD DC D SDEASC + C
Sbjct: 105 PPKTCSQDEFRCH-DGKCISRQFVCDSDRDCLDGSDEASCPVLTC 148
Score = 47.0 bits (110), Expect = 1e-04
Identities = 22/50 (44%), Positives = 30/50 (60%), Gaps = 2/50 (4%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV-MEVCSFEKRSLC 463
C +EF C SDG+CI ++CD +YDC D SDE CV + +C + C
Sbjct: 236 CRPDEFQC-SDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKC 284
Score = 44.3 bits (103), Expect = 0.001
Identities = 30/85 (35%), Positives = 37/85 (43%), Gaps = 13/85 (15%)
Query: 1113 GEISELCPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFET 1168
G + CP T +F C D KCI+ +CD DC SDEA C T G +F+
Sbjct: 98 GSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCP--VLTCGPASFQC 155
Query: 1169 SSGN-----WTTACSLTQDSEDDLD 1188
+S W AC D ED D
Sbjct: 156 NSSTCIPQLW--ACDNDPDCEDGSD 178
Score = 41.2 bits (95), Expect = 0.008
Identities = 18/52 (34%), Positives = 28/52 (53%), Gaps = 3/52 (5%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETT---FICRTSSGRCD 673
P + C+ EF C + CI++ +CD DC D SDE + C +S +C+
Sbjct: 105 PPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCN 156
Score = 41.2 bits (95), Expect = 0.008
Identities = 19/41 (46%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVC 455
C+ EF C S G CI +CD DC DKSDE +C + C
Sbjct: 197 CSAFEFHCLS-GECIHSSWRCDGGPDCKDKSDEENCAVATC 236
Score = 40.8 bits (94), Expect = 0.010
Identities = 33/108 (30%), Positives = 43/108 (39%), Gaps = 14/108 (12%)
Query: 1084 EPECPRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKP 1143
+P+C G E P R L S C +F C +CI S CD P
Sbjct: 170 DPDCEDGSD--------EWPQRCRGLYVFQGDSSPCSAF-EFHCLSGECIHSSWRCDGGP 220
Query: 1144 DCSGRSDEAHCAHYTSTTGSCNFETSSGN---WTTACSLTQDSEDDLD 1188
DC +SDE +CA +T F+ S GN + C D +D D
Sbjct: 221 DCKDKSDEENCA--VATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
Score = 36.2 bits (82), Expect = 0.25
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 632 HEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTS 668
++F C + CI DK+C+ DC D SDE C T+
Sbjct: 280 NKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTN 316
Score = 35.8 bits (81), Expect = 0.33
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 13/76 (17%)
Query: 184 PAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC------APELQCNFETGI- 236
P ++C D F C H CI + +CD DC D +DE +C QCN T I
Sbjct: 105 PPKTCSQ-DEFRC-HDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIP 162
Query: 237 ----CNWEQDAKDDFD 248
C+ + D +D D
Sbjct: 163 QLWACDNDPDCEDGSD 178
Score = 35.4 bits (80), Expect = 0.43
Identities = 19/71 (26%), Positives = 32/71 (45%), Gaps = 8/71 (11%)
Query: 628 KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDET-----TFICRTSSGRCDFEFDLC--- 679
+C +EF C + CI+ +CD +C D SDE+ + C++ C + C
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 680 SWKQEKDEDFD 690
W+ + D D
Sbjct: 86 FWRCDGQVDCD 96
Score = 35.4 bits (80), Expect = 0.43
Identities = 19/55 (34%), Positives = 26/55 (47%), Gaps = 6/55 (10%)
Query: 403 ETSVPVTLPPHNCTDNEFICRSD-GHCIEKMQKCDFKYDCPDKSDEASCVMEVCS 456
ET + VT C +F C CI + +CD + DC + SDE C + CS
Sbjct: 61 ETCLSVT-----CKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCS 110
Score = 35.0 bits (79), Expect = 0.56
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 3/43 (6%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEA--SCVMEVC 455
C NEF C+ DG CI CD +C D SDE+ +C+ C
Sbjct: 27 CERNEFQCQ-DGKCISYKWVCDGSAECQDGSDESQETCLSVTC 68
Score = 34.3 bits (77), Expect = 0.96
Identities = 14/32 (43%), Positives = 18/32 (56%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C EF C++ +CI + CD DC D SDE
Sbjct: 236 CRPDEFQCSDGNCIHGSRQCDREYDCKDMSDE 267
Score = 34.3 bits (77), Expect = 0.96
Identities = 15/43 (34%), Positives = 25/43 (58%), Gaps = 3/43 (6%)
Query: 854 ECHNGKCYRLEQSCNFVDNCGDNTGE--NKCGSS-CTFEKGWC 893
+CH+G+C L++ CN +C D + E +CG++ C G C
Sbjct: 283 KCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGC 325
Score = 33.1 bits (74), Expect = 2.1
Identities = 17/47 (36%), Positives = 20/47 (42%), Gaps = 3/47 (6%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE---TTFICRTSSGRC 672
C+ EF C + CI CD DC D SDE CR +C
Sbjct: 197 CSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQC 243
Score = 33.1 bits (74), Expect = 2.1
Identities = 22/58 (37%), Positives = 26/58 (44%), Gaps = 11/58 (18%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNCA------PELQCNFETGI-----CNWEQDAKDDFD 248
CI CD DC D++DE NCA E QC+ I C+ E D KD D
Sbjct: 209 CIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
Score = 32.0 bits (71), Expect = 4.8
Identities = 27/97 (27%), Positives = 34/97 (35%), Gaps = 8/97 (8%)
Query: 1114 EISELCPEIT----DFLC--RDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFE 1167
E E C +T DF C R +CI CD + DC SDE C T F
Sbjct: 58 ESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCP--PKTCSQDEFR 115
Query: 1168 TSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDS 1204
G + + D LD + + P P S
Sbjct: 116 CHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPAS 152
Score = 32.0 bits (71), Expect = 4.8
Identities = 30/107 (28%), Positives = 37/107 (34%), Gaps = 24/107 (22%)
Query: 177 ENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCAPELQCNFET-- 234
ENC + +C D F C CI R CD DC D +DEV C C
Sbjct: 229 ENCAVA----TCRP-DEFQCSDGN-CIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKF 282
Query: 235 -----------GICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLG 270
+CN +D + DW + P T DN G
Sbjct: 283 KCHSGECITLDKVCNMARDCR---DW--SDEPIKECGTNECLDNNGG 324
Score = 31.6 bits (70), Expect = 6.2
Identities = 15/37 (40%), Positives = 16/37 (43%), Gaps = 4/37 (10%)
Query: 1119 CPEIT----DFLCRDKKCIASHLLCDYKPDCSGRSDE 1151
CP +T F C CI CD PDC SDE
Sbjct: 143 CPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDE 179
Score = 31.6 bits (70), Expect = 6.2
Identities = 16/42 (38%), Positives = 18/42 (42%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICR 666
P C F C + CI + CD DC D SDE CR
Sbjct: 144 PVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCR 185
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 82.8 bits (203), Expect = 2e-15
Identities = 48/121 (39%), Positives = 62/121 (51%), Gaps = 11/121 (9%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C + F C +T +C+ S CDG++DC D SDE +C NPT E C CI
Sbjct: 306 CSENLFHC-HTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPT------TEHRCGDGRCIAM 358
Query: 1398 LLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
+CDG DC DE+ C SC + LV + CIP+ +CDG DC D DE +C
Sbjct: 359 EWVCDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGS-DEENC 414
Query: 1458 S 1458
S
Sbjct: 415 S 415
Score = 74.7 bits (182), Expect = 6e-13
Identities = 50/144 (34%), Positives = 68/144 (47%), Gaps = 25/144 (17%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNME-FPC-STDECI 1395
C F C + QCV S +CDG DC D SDE +C C + + C S +C+
Sbjct: 580 CSPSHFKC-RSGQCVLASRRCDGQADCDDDSDEENCG-------CKERDLWECPSNKQCL 631
Query: 1396 PSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1455
++CDG PDC DE CS C + L CA +++C+ CDG ADC D
Sbjct: 632 KHTVICDGFPDCPDYMDEKNCS--FCQDDELECA-NHACVSRDLWCDGEADCSD------ 682
Query: 1456 SCSDTWTLLGIGL-----AFLMTH 1474
SD W + + + +FLM H
Sbjct: 683 -SSDEWDCVTLSINVNSSSFLMVH 705
Score = 50.1 bits (118), Expect = 2e-05
Identities = 45/150 (30%), Positives = 62/150 (41%), Gaps = 21/150 (14%)
Query: 1323 PECVTGGP-----VPVQPSPCEADQFSCIYTLQCVPLSG----KCDGHEDCIDGSDEMDC 1373
PEC+ G +P + S CEA + C L V S +C + + S+
Sbjct: 197 PECIIDGDDSHGLLPCR-SFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRI 255
Query: 1374 PLNPTPP-----LCSNME-FPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALV 1427
+P LC E F C++ CIP L C+G DC DE C +CS
Sbjct: 256 CFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCSENLFH 312
Query: 1428 CASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
C + C+ CDG+ DC D DE +C
Sbjct: 313 C-HTGKCLNYSLVCDGYDDCGDLS-DEQNC 340
Score = 46.6 bits (109), Expect = 2e-04
Identities = 26/68 (38%), Positives = 34/68 (50%), Gaps = 5/68 (7%)
Query: 1350 QCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHF 1409
QC+P + +CDG EDC DGSDE +C + T C + C + C+ S C G C
Sbjct: 391 QCIPSTFQCDGDEDCKDGSDEENCSVIQTS--CQEGDQRCLYNPCLDS---CGGSSLCDP 445
Query: 1410 NEDELICS 1417
N CS
Sbjct: 446 NNSLNNCS 453
Score = 42.4 bits (98), Expect = 0.004
Identities = 19/47 (40%), Positives = 26/47 (55%), Gaps = 2/47 (4%)
Query: 616 FQDCSPLLSPERK--CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
F DC + + C D E CAN C+++D CD DC+D+SDE
Sbjct: 640 FPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDE 686
Score = 40.4 bits (93), Expect = 0.013
Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 2/90 (2%)
Query: 1099 PQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYT 1158
P+E + ++ L+ + E P + F CR +C+ + CD + DC SDE +C
Sbjct: 561 PEENSDNQTCLMPDEYVEECSP--SHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKE 618
Query: 1159 STTGSCNFETSSGNWTTACSLTQDSEDDLD 1188
C T C D D +D
Sbjct: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMD 648
Score = 39.7 bits (91), Expect = 0.023
Identities = 26/86 (30%), Positives = 36/86 (41%), Gaps = 16/86 (18%)
Query: 172 DDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCA----PE 227
DD ENC C+ D + C + C++ +CD DC D DE NC+ E
Sbjct: 607 DDSDEENC-------GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDE 659
Query: 228 LQCNFETGI-----CNWEQDAKDDFD 248
L+C + C+ E D D D
Sbjct: 660 LECANHACVSRDLWCDGEADCSDSSD 685
Score = 39.3 bits (90), Expect = 0.030
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 1119 CPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETSSGNWTTACS 1178
C T+ C D +CIA +CD DC +SDE +C+ ++ C + T C
Sbjct: 342 CNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPS-TFQCD 400
Query: 1179 LTQDSEDDLD 1188
+D +D D
Sbjct: 401 GDEDCKDGSD 410
Score = 38.9 bits (89), Expect = 0.039
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 4/55 (7%)
Query: 616 FQDCSPLLSPERKCTDH---EFMCANKHCIAKDKLCDFVNDCADNSDETTFICRT 667
+ DC L S E+ C + E C + CIA + +CD +DC D SDE C +
Sbjct: 328 YDDCGDL-SDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHS 381
Score = 38.9 bits (89), Expect = 0.039
Identities = 16/36 (44%), Positives = 23/36 (63%), Gaps = 1/36 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
C+ + F CRS G C+ ++CD + DC D SDE +C
Sbjct: 580 CSPSHFKCRS-GQCVLASRRCDGQADCDDDSDEENC 614
Score = 37.7 bits (86), Expect = 0.087
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 9/70 (12%)
Query: 188 CEGLDHFWCRHTRACIEKLRLCDLVDDCGDRTDEVNC---------APELQCNFETGICN 238
C ++ + HT C+ +CD DDCGD +DE NC + +C +C+
Sbjct: 304 CNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCD 363
Query: 239 WEQDAKDDFD 248
+ D D D
Sbjct: 364 GDHDCVDKSD 373
Score = 36.6 bits (83), Expect = 0.19
Identities = 17/37 (45%), Positives = 19/37 (51%)
Query: 1118 LCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
LC +FLC CI L C+ DC SDEAHC
Sbjct: 268 LCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC 304
Score = 36.2 bits (82), Expect = 0.25
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 3/59 (5%)
Query: 848 CPLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSCTFEKGWCGWQNSQADNFDWV 906
C CH GKC C+ D+CGD + E C + T E CG + + +WV
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHR-CG--DGRCIAMEWV 361
Score = 36.2 bits (82), Expect = 0.25
Identities = 28/84 (33%), Positives = 34/84 (40%), Gaps = 13/84 (15%)
Query: 177 ENCTLPLPAESCEGLD--HFWCRHTRACIEKLRLCDLVDDCGDRTDEVNCA--------- 225
+N T +P E E HF CR + C+ R CD DC D +DE NC
Sbjct: 566 DNQTCLMPDEYVEECSPSHFKCRSGQ-CVLASRRCDGQADCDDDSDEENCGCKERDLWEC 624
Query: 226 -PELQCNFETGICNWEQDAKDDFD 248
QC T IC+ D D D
Sbjct: 625 PSNKQCLKHTVICDGFPDCPDYMD 648
Score = 35.4 bits (80), Expect = 0.43
Identities = 20/62 (32%), Positives = 28/62 (45%), Gaps = 2/62 (3%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICR-TSSGRC-DFEFDLCSWKQEKD 686
C+++ F C C+ +CD +DC D SDE C T+ RC D W + D
Sbjct: 306 CSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGD 365
Query: 687 ED 688
D
Sbjct: 366 HD 367
Score = 35.4 bits (80), Expect = 0.43
Identities = 19/40 (47%), Positives = 21/40 (52%), Gaps = 4/40 (10%)
Query: 414 NCTDN---EFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
NC N E C DG CI CD +DC DKSDE +C
Sbjct: 339 NCDCNPTTEHRC-GDGRCIAMEWVCDGDHDCVDKSDEVNC 377
Score = 35.0 bits (79), Expect = 0.56
Identities = 16/37 (43%), Positives = 21/37 (56%), Gaps = 1/37 (2%)
Query: 414 NCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
NC++N F C + G C+ CD DC D SDE +C
Sbjct: 305 NCSENLFHCHT-GKCLNYSLVCDGYDDCGDLSDEQNC 340
Score = 34.7 bits (78), Expect = 0.73
Identities = 20/56 (35%), Positives = 27/56 (48%), Gaps = 9/56 (16%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNCAPEL---------QCNFETGICNWEQDAKDDFD 248
CI +CD DC D++DEVNC+ QC T C+ ++D KD D
Sbjct: 355 CIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSD 410
Score = 34.7 bits (78), Expect = 0.73
Identities = 13/39 (33%), Positives = 20/39 (51%)
Query: 628 KCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICR 666
+C+ F C + C+ + CD DC D+SDE C+
Sbjct: 579 ECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCK 617
Score = 33.5 bits (75), Expect = 1.6
Identities = 15/37 (40%), Positives = 20/37 (54%), Gaps = 1/37 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
C D+E C + C+ + CD + DC D SDE CV
Sbjct: 655 CQDDELECANHA-CVSRDLWCDGEADCSDSSDEWDCV 690
Score = 33.5 bits (75), Expect = 1.6
Identities = 14/40 (35%), Positives = 20/40 (50%)
Query: 1127 CRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNF 1166
C + C++ L CD + DCS SDE C + S +F
Sbjct: 662 CANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSF 701
Score = 32.7 bits (73), Expect = 2.8
Identities = 15/40 (37%), Positives = 19/40 (47%)
Query: 1125 FLCRDKKCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSC 1164
F C KC+ L+CD DC SDE +C +T C
Sbjct: 311 FHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRC 350
Score = 32.7 bits (73), Expect = 2.8
Identities = 13/29 (44%), Positives = 17/29 (58%)
Query: 1127 CRDKKCIASHLLCDYKPDCSGRSDEAHCA 1155
CR+ +CI S CD DC SDE +C+
Sbjct: 387 CRNGQCIPSTFQCDGDEDCKDGSDEENCS 415
Score = 31.6 bits (70), Expect = 6.2
Identities = 22/71 (30%), Positives = 34/71 (47%), Gaps = 11/71 (15%)
Query: 155 LSLDKVSLGIYDGVSAIDDIRFENCTLPLPAESCEGLDHFWCRHTRACIEKLRLCDLVDD 214
++++ V G +D V D++ NC SC CR+ + CI CD +D
Sbjct: 356 IAMEWVCDGDHDCVDKSDEV---NC-------SCHSQGLVECRNGQ-CIPSTFQCDGDED 404
Query: 215 CGDRTDEVNCA 225
C D +DE NC+
Sbjct: 405 CKDGSDEENCS 415
Score = 31.2 bits (69), Expect = 8.1
Identities = 15/39 (38%), Positives = 19/39 (48%)
Query: 634 FMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRC 672
F+CA+ CI C+ NDC D SDE C + C
Sbjct: 275 FLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHC 313
Score = 31.2 bits (69), Expect = 8.1
Identities = 14/29 (48%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Query: 422 CRSDGHCIEKMQKCDFKYDCPDKSDEASC 450
CR+ G CI +CD DC D SDE +C
Sbjct: 387 CRN-GQCIPSTFQCDGDEDCKDGSDEENC 414
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 82.4 bits (202), Expect = 3e-15
Identities = 46/120 (38%), Positives = 54/120 (45%), Gaps = 9/120 (7%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C + C CVP CD +DC DGSDE C P C + CS+ C+P
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGC----AAPGCGEGQMTCSSGHCLPL 1431
Query: 1398 LLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
LLCD DC DE + C G L CA C+P CDG DC+D DE SC
Sbjct: 1432 ALLCDRQDDCGDGTDE---PSYPCPQGLLACADGR-CLPPALLCDGHPDCLD-AADEESC 1486
Score = 72.8 bits (177), Expect = 2e-12
Identities = 42/113 (37%), Positives = 55/113 (48%), Gaps = 10/113 (8%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C Q +C + C+PL+ CD +DC DG+DE P C C+ C+P
Sbjct: 1416 CGEGQMTCS-SGHCLPLALLCDRQDDCGDGTDEPSYP-------CPQGLLACADGRCLPP 1467
Query: 1398 LLLCDGVPDCHFNEDELICSNK-SCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
LLCDG PDC DE C + +C G + C +C+ A Q CDG DC D
Sbjct: 1468 ALLCDGHPDCLDAADEESCLGQVTCVPGEVSCV-DGTCLGAIQLCDGVWDCPD 1519
Score = 63.2 bits (152), Expect = 2e-09
Identities = 53/165 (32%), Positives = 66/165 (40%), Gaps = 33/165 (20%)
Query: 1322 TPECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLN----- 1376
TP + P P P C Q C L CV + CDG EDC+DGSDE C N
Sbjct: 2375 TPAGQSVAPGPFPPVQCGPGQTPC-EVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWL 2433
Query: 1377 PTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIP 1436
P+ P + ST + + G+P S CS L C S C+
Sbjct: 2434 PSLPAL----WAASTVPFMMPTMALPGLP----------ASRALCSPSQLSC-GSGECLS 2478
Query: 1437 AHQRCDGFADCMDFQLDESSCSD----TWTL-------LGIGLAF 1470
A +RCD DC D DE C D W++ G+GL F
Sbjct: 2479 AERRCDLRPDCQDGS-DEDGCVDCVLAPWSVWSSCSRSCGLGLTF 2522
Score = 62.8 bits (151), Expect = 3e-09
Identities = 48/152 (31%), Positives = 56/152 (36%), Gaps = 43/152 (28%)
Query: 1340 ADQFSCIYTLQCVP-----LSGKC-------DGHEDCIDGSDEMD--CPLN--PTPPL-- 1381
AD+ SC+ + CVP + G C DG DC DG+DE CPL PTPP
Sbjct: 1481 ADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPAST 1540
Query: 1382 ------------------------CSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELICS 1417
C EF C + EC P CD DC DE C
Sbjct: 1541 LPGPSPGSLDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCG 1600
Query: 1418 NKSCSNGALVCASSNSCIPAHQRCDGFADCMD 1449
C+ CA C+ Q CDG C D
Sbjct: 1601 G-PCAPHHAPCARGPHCVSPEQLCDGVRQCPD 1631
Score = 58.2 bits (139), Expect = 6e-08
Identities = 42/130 (32%), Positives = 51/130 (39%), Gaps = 33/130 (25%)
Query: 1337 PCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCST-DECI 1395
PC +F C + +C P +CD EDC DGSDE C P C+ PC+ C+
Sbjct: 1564 PCGPFEFRC-GSGECTPRGWRCDQEEDCADGSDERGCG-GP----CAPHHAPCARGPHCV 1617
Query: 1396 PSLLLCDGVPDCHFNEDE------------------LICSNKSCSNGALVCASSNSCIPA 1437
LCDGV C DE L C +C NG +CI
Sbjct: 1618 SPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNG--------TCIGF 1669
Query: 1438 HQRCDGFADC 1447
CDG DC
Sbjct: 1670 QLVCDGQPDC 1679
Score = 49.3 bits (116), Expect = 3e-05
Identities = 26/71 (36%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 1380 PLCSNMEFPCSTD-ECIPSLLLCDGVPDCHFNEDELICSNKSCSNGALVCASSNSCIPAH 1438
P C+ E C + C+P LCD DC DE C+ C G + C SS C+P
Sbjct: 1374 PACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTC-SSGHCLPLA 1432
Query: 1439 QRCDGFADCMD 1449
CD DC D
Sbjct: 1433 LLCDRQDDCGD 1443
Score = 46.6 bits (109), Expect = 2e-04
Identities = 29/91 (31%), Positives = 32/91 (35%), Gaps = 7/91 (7%)
Query: 1324 ECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPL-- 1381
+C G PC C CV CDG C DGSDE P L
Sbjct: 1589 DCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGG 1648
Query: 1382 -----CSNMEFPCSTDECIPSLLLCDGVPDC 1407
E+ C CI L+CDG PDC
Sbjct: 1649 PNRTGLPCPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 45.8 bits (107), Expect = 3e-04
Identities = 22/62 (35%), Positives = 31/62 (50%), Gaps = 1/62 (1%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIPVHLL 474
C + E +C+ +GHC+ CD + DC D SDE C C E + C +P+ LL
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCG-EGQMTCSSGHCLPLALL 1434
Query: 475 QD 476
D
Sbjct: 1435 CD 1436
Score = 42.0 bits (97), Expect = 0.005
Identities = 28/96 (29%), Positives = 36/96 (37%), Gaps = 19/96 (19%)
Query: 385 MDCTLYPGNLPADLPTPPETSVPVT----------LPPHNCTDNEFICRSDGHCIEKMQK 434
M+ P + A PP P T PP C + C G C+E+ Q
Sbjct: 2351 MEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLG-CVEQAQV 2409
Query: 435 CDFKYDCPDKSDEASCVMEVCSFEKRSLCKWYQPIP 470
CD + DC D SDE C R+L W +P
Sbjct: 2410 CDGREDCLDGSDERHCA--------RNLLMWLPSLP 2437
Score = 41.6 bits (96), Expect = 0.006
Identities = 42/138 (30%), Positives = 47/138 (34%), Gaps = 5/138 (3%)
Query: 1114 EISELCPEITDFLCRDKKCIASHLLCDYKPDCSGRSDEAHC-AHYTSTTG--SCNFETSS 1170
E S CP+ C D +C+ LLCD PDC +DE C T G SC T
Sbjct: 1447 EPSYPCPQGL-LACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCL 1505
Query: 1171 GNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKEGSVARI 1230
G C D D D G P + PG L SS S A
Sbjct: 1506 GA-IQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPP 1564
Query: 1231 TTSKSFPASLGMCTVRFW 1248
F G CT R W
Sbjct: 1565 CGPFEFRCGSGECTPRGW 1582
Score = 40.0 bits (92), Expect = 0.017
Identities = 26/76 (34%), Positives = 33/76 (43%), Gaps = 17/76 (22%)
Query: 391 PGNLPA-DLPTPPETSVP---------------VTLPPHNCTDNEFICRSDGHCIEKMQK 434
PG+ P LPTPP +++P P C EF C S G C + +
Sbjct: 1525 PGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPFEFRCGS-GECTPRGWR 1583
Query: 435 CDFKYDCPDKSDEASC 450
CD + DC D SDE C
Sbjct: 1584 CDQEEDCADGSDERGC 1599
Score = 38.9 bits (89), Expect = 0.039
Identities = 16/49 (32%), Positives = 26/49 (53%), Gaps = 5/49 (10%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFIC-----RTSSGRC 672
C + + C++ HC+ LCD +DC D +DE ++ C + GRC
Sbjct: 1416 CGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRC 1464
Score = 37.7 bits (86), Expect = 0.087
Identities = 16/38 (42%), Positives = 20/38 (52%), Gaps = 1/38 (2%)
Query: 629 CTDHEFMCAN-KHCIAKDKLCDFVNDCADNSDETTFIC 665
C H CA HC++ ++LCD V C D SDE C
Sbjct: 1603 CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDAC 1640
Score = 37.0 bits (84), Expect = 0.15
Identities = 19/43 (44%), Positives = 21/43 (48%), Gaps = 2/43 (4%)
Query: 620 SPLLS--PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
SPL S P C EF C + C + CD DCAD SDE
Sbjct: 1554 SPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDE 1596
Score = 37.0 bits (84), Expect = 0.15
Identities = 17/43 (39%), Positives = 22/43 (51%)
Query: 1374 PLNPTPPLCSNMEFPCSTDECIPSLLLCDGVPDCHFNEDELIC 1416
P +P PLC + C++ EC+ CDGV DC DE C
Sbjct: 2226 PGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 37.0 bits (84), Expect = 0.15
Identities = 15/37 (40%), Positives = 22/37 (59%), Gaps = 1/37 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCV 451
C+ ++ C S G C+ ++CD + DC D SDE CV
Sbjct: 2464 CSPSQLSCGS-GECLSAERRCDLRPDCQDGSDEDGCV 2499
Score = 37.0 bits (84), Expect = 0.15
Identities = 35/126 (27%), Positives = 48/126 (38%), Gaps = 27/126 (21%)
Query: 1324 ECVTGGPVPVQPSPCEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCS 1383
E GGP P CEA ++TL C + +C C D D + C P P C
Sbjct: 4657 ESCNGGPCP----ECEAQD--TVFTLDC---ANQCP--HSCADLWDRVQCLQGPCRPGCR 4705
Query: 1384 NMEFPCSTD-ECIPSLLLCDGVPDCHFNED-------ELICSNKSCSNGALVCASSNSCI 1435
D C+P G+P + + + +L C N +C N +LVC
Sbjct: 4706 CPPGQLVQDGRCVPISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVC------- 4758
Query: 1436 PAHQRC 1441
HQ C
Sbjct: 4759 -PHQEC 4763
Score = 36.6 bits (83), Expect = 0.19
Identities = 23/54 (42%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 1325 CVTGGPVPVQPSP-CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNP 1377
C G P P+P C C + +CV G CDG DC DGSDE C L P
Sbjct: 2224 CEPGSP----PAPLCPGVGLRCA-SGECVLRGGPCDGVLDCEDGSDEEGCVLLP 2272
Score = 35.8 bits (81), Expect = 0.33
Identities = 20/57 (35%), Positives = 24/57 (42%), Gaps = 4/57 (7%)
Query: 608 DVAVDDISFQ----DCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
DV D+ Q C P P C CA+ C+ + CD V DC D SDE
Sbjct: 2209 DVHHSDVPLQVELLGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 35.0 bits (79), Expect = 0.56
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 629 CTDHEFMCA-NKHCIAKDKLCDFVNDCADNSDE 660
C + E +C N HC+ LCD +DC D SDE
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE 1408
Score = 34.3 bits (77), Expect = 0.96
Identities = 14/30 (46%), Positives = 17/30 (56%)
Query: 196 CRHTRACIEKLRLCDLVDDCGDRTDEVNCA 225
C+ C+ LCD DDCGD +DE CA
Sbjct: 1383 CQENGHCVPHGWLCDNQDDCGDGSDEEGCA 1412
Score = 34.3 bits (77), Expect = 0.96
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 1/44 (2%)
Query: 411 PPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV 454
P + C C +DG C+ CD DC D +DE SC+ +V
Sbjct: 1448 PSYPCPQGLLAC-ADGRCLPPALLCDGHPDCLDAADEESCLGQV 1490
Score = 34.3 bits (77), Expect = 0.96
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
C E C DG C+ +Q CD +DCPD +DE
Sbjct: 1492 CVPGEVSC-VDGTCLGAIQLCDGVWDCPDGADE 1523
Score = 33.5 bits (75), Expect = 1.6
Identities = 11/32 (34%), Positives = 18/32 (56%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C+ + C + C++ ++ CD DC D SDE
Sbjct: 2464 CSPSQLSCGSGECLSAERRCDLRPDCQDGSDE 2495
Score = 33.1 bits (74), Expect = 2.1
Identities = 20/72 (27%), Positives = 30/72 (41%), Gaps = 1/72 (1%)
Query: 1083 PEPECPRGRSALLKGPPQEEPNRRSALLSVGEISELCPEITDFLCRDKKCIASHLLCDYK 1142
P P P ++ L GP + S+ L+ + C +F C +C CD +
Sbjct: 1529 PLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGPF-EFRCGSGECTPRGWRCDQE 1587
Query: 1143 PDCSGRSDEAHC 1154
DC+ SDE C
Sbjct: 1588 EDCADGSDERGC 1599
Score = 32.0 bits (71), Expect = 4.8
Identities = 25/77 (32%), Positives = 33/77 (42%), Gaps = 6/77 (7%)
Query: 1113 GEISELCPEITD--FLCRDK-KCIASHLLCDYKPDCSGRSDEAHCAHYTSTTGSCNFETS 1169
G EL P + LC++ C+ LCD + DC SDE CA G S
Sbjct: 1367 GHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCA--APGCGEGQMTCS 1424
Query: 1170 SGNWTTACSLTQDSEDD 1186
SG+ +L D +DD
Sbjct: 1425 SGH-CLPLALLCDRQDD 1440
Score = 32.0 bits (71), Expect = 4.8
Identities = 13/32 (40%), Positives = 17/32 (53%)
Query: 629 CTDHEFMCANKHCIAKDKLCDFVNDCADNSDE 660
C E C + C+ +LCD V DC D +DE
Sbjct: 1492 CVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 1523
Score = 32.0 bits (71), Expect = 4.8
Identities = 13/33 (39%), Positives = 15/33 (45%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDE 447
C + C HC+ Q CD CPD SDE
Sbjct: 1603 CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDE 1635
Score = 31.6 bits (70), Expect = 6.2
Identities = 14/35 (40%), Positives = 19/35 (54%), Gaps = 1/35 (2%)
Query: 415 CTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEAS 449
C + + C S GHC+ CD + DC D +DE S
Sbjct: 1416 CGEGQMTC-SSGHCLPLALLCDRQDDCGDGTDEPS 1449
Score = 31.6 bits (70), Expect = 6.2
Identities = 22/92 (23%), Positives = 34/92 (36%), Gaps = 9/92 (9%)
Query: 625 PERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTS---------SGRCDFE 675
P C CA+ C+ LCD DC D +DE + + + + G C
Sbjct: 1448 PSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGA 1507
Query: 676 FDLCSWKQEKDEDFDWNLKASSIPAAGTEPAA 707
LC + + D +P+ T PA+
Sbjct: 1508 IQLCDGVWDCPDGADEGPGHCPLPSLPTPPAS 1539
Score = 31.6 bits (70), Expect = 6.2
Identities = 17/55 (30%), Positives = 25/55 (45%), Gaps = 2/55 (3%)
Query: 833 DSVQEELAVPLPTGFC-PLGYRECHNGKCYRLEQSCNFVDNCGDNTGENKCGSSC 886
D+ LA P C P +R C +G+C C+ ++C D + E CG C
Sbjct: 1550 DTASSPLASASPAPPCGPFEFR-CGSGECTPRGWRCDQEEDCADGSDERGCGGPC 1603
Score = 31.6 bits (70), Expect = 6.2
Identities = 11/28 (39%), Positives = 16/28 (57%)
Query: 1127 CRDKKCIASHLLCDYKPDCSGRSDEAHC 1154
C +C+++ CD +PDC SDE C
Sbjct: 2471 CGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 31.2 bits (69), Expect = 8.1
Identities = 17/46 (36%), Positives = 21/46 (45%), Gaps = 1/46 (2%)
Query: 407 PVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVM 452
P + P C C S G C+ + CD DC D SDE CV+
Sbjct: 2226 PGSPPAPLCPGVGLRCAS-GECVLRGGPCDGVLDCEDGSDEEGCVL 2270
Score = 31.2 bits (69), Expect = 8.1
Identities = 12/27 (44%), Positives = 19/27 (70%)
Query: 202 CIEKLRLCDLVDDCGDRTDEVNCAPEL 228
C+E+ ++CD +DC D +DE +CA L
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNL 2429
>gi|16554449 zonadhesin isoform 3 [Homo sapiens]
Length = 2812
Score = 81.3 bits (199), Expect = 7e-15
Identities = 139/612 (22%), Positives = 215/612 (35%), Gaps = 138/612 (22%)
Query: 229 QCNFETG---ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQ 285
QC+FE +C+W Q + DD DW R GP+PT +TG G +G YL++ES+
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNG--EGSYLHMESNSFH 97
Query: 286 AFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQ---LLWQIFG 342
A LLSP L + F +HMFG + + + S G+ +LW+ +
Sbjct: 98 R-GGVARLLSPDL--WEQGPLCVHFAHHMFGLS-WGAQLRLLLLSGEEGRRPDVLWKHWN 153
Query: 343 NQGNRWIRKHLNISS--RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPT 400
Q W+ + + + P +++ E + G DIA+D LS
Sbjct: 154 TQRPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS----------------- 196
Query: 401 PPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKR 460
I R + + MQ C F D P+
Sbjct: 197 --------------------IRRGSCNRVCMMQTCSF--DIPN----------------- 217
Query: 461 SLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNG 520
LC W + ++ +W G S G+ P D + + G Y+ D N
Sbjct: 218 DLCDW------TWIPTASGAKWTQKKGSS---GKPGVGPDGDFS-SPGSGCYMLLDPKNA 267
Query: 521 KFGDTADILTPIISLTGPKCTLVFWTHMNGATVG-SLQVLIKKDNVTSKLWAQTGQQGAQ 579
+ G A +L+P +SL+ + F + G + G +L + K +GQ G
Sbjct: 268 RPGQKAVLLSP-VSLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLFSGQPGPN 326
Query: 580 WKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANK 639
W+ V Q G + VAVD S C
Sbjct: 327 WQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSIAPCG------------------- 367
Query: 640 HCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE---FDLCSWKQEKDEDFDWNLKAS 696
+CDFE C W Q + W L
Sbjct: 368 ---------------------------EGFPQCDFEDNAHPFCDWVQTSGDGGHWALGHK 400
Query: 697 SIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMY 756
+ P G PA N+ GHYI++ + Q ++ R+ S C + F YHMY
Sbjct: 401 NGPVHGMGPAGG--FPNAGGHYIYLEADEFSQAGQSVRLVSRPFCAPGDIC-VEFAYHMY 457
Query: 757 GNGIGA-LTLMQVSVTNQTKVLLNLTV-EQGNFWRREELSLFG--DEDFQLKFEGRVGKG 812
G G G L L+ S + L V Q +W+ +++ + QL F+G G
Sbjct: 458 GLGEGTMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSN 517
Query: 813 QRGDIALDDIVL 824
+A+ I++
Sbjct: 518 TASVVAMGFILI 529
Score = 52.4 bits (124), Expect = 3e-06
Identities = 87/385 (22%), Positives = 142/385 (36%), Gaps = 63/385 (16%)
Query: 444 KSDEASCVMEVCSFEK--RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSV 501
+S + V+ C FE + LC W Q + D + G + G P+
Sbjct: 30 RSSRDNYVLTQCDFEDDAKPLCDWSQ-----VSADDEDWVRASGPSPTGSTGAPGGYPN- 83
Query: 502 DHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGS-LQVLI 560
+G YL+ +S++ G A +L+P + GP C + F HM G + G+ L++L+
Sbjct: 84 ------GEGSYLHMESNSFHRGGVARLLSPDLWEQGPLC-VHFAHHMFGLSWGAQLRLLL 136
Query: 561 ---KKDNVTSKLWAQTGQQGAQWKRAEVFL--GIRSHTQIVFRAKRGISYIGDVAVDDIS 615
++ LW Q W V + G T+++F RG + D+A+D +S
Sbjct: 137 LSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS 196
Query: 616 FQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE 675
+ S N+ C+ + D ND D T+I S +
Sbjct: 197 IRRGS----------------CNRVCMMQTCSFDIPNDLCD----WTWIPTASGAK---- 232
Query: 676 FDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARI 735
W K S G P D + SG Y+ ++ +P + A +
Sbjct: 233 ---------------WTQKKGSSGKPGVGPDGDFS-SPGSGCYMLLDPK-NARPGQKAVL 275
Query: 736 SSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSL 795
SPV S S FHY + G GA + SV + + + G W+ ++
Sbjct: 276 LSPV-SLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLFSGQPGPNWQAVSVNY 334
Query: 796 FGDEDFQLKFEGRVGKGQRGDIALD 820
Q G GK +A+D
Sbjct: 335 TAVGRIQFAVVGVFGKTPEPAVAVD 359
Score = 48.9 bits (115), Expect = 4e-05
Identities = 49/194 (25%), Positives = 75/194 (38%), Gaps = 23/194 (11%)
Query: 229 QCNFETG---ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSE-P 284
QC+FE C+W Q + D W P GP A GHY+Y+E+ E
Sbjct: 372 QCDFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPA--GGFPNAGGHYIYLEADEFS 429
Query: 285 QAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQ---LLWQIF 341
QA Q + P D F YHM+G + + + + G LW+
Sbjct: 430 QAGQSVRLVSRPFCAPGD---ICVEFAYHMYG--LGEGTMLELLLGSPAGSPPIPLWKRV 484
Query: 342 GNQGNRWIRKHLNISS--RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADL- 398
G+Q W + + S +QP Q++ + G +A+ + + PG P +
Sbjct: 485 GSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSNTASVVAMGFI-----LINPGTCPVKVL 539
Query: 399 -PTPPETSVPVTLP 411
PP + V T P
Sbjct: 540 PELPPVSPVSSTGP 553
Score = 46.6 bits (109), Expect = 2e-04
Identities = 83/340 (24%), Positives = 124/340 (36%), Gaps = 52/340 (15%)
Query: 671 RCDFEFD---LCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQ 727
+CDFE D LC W Q +D DW + P T + G S ++ NS
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSF--- 96
Query: 728 QPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGA---LTLMQVSVTNQTKVLLNLTVEQ 784
AR+ SP + ++ C + F +HM+G GA L L+ + VL Q
Sbjct: 97 HRGGVARLLSPDLWEQGPLC-VHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 785 GNFWRREELSLFGDEDF--QLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVP 842
W +++ +L FEG G DIALD A+
Sbjct: 156 RPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALD-------------------ALS 196
Query: 843 LPTGFCPLGYRECHNGKCYRLEQSCNF---VDNCGDNTGENKCGSSCTFEKGWCGWQNSQ 899
+ G C N C + Q+C+F D C G+ T +KG G
Sbjct: 197 IRRGSC--------NRVC--MMQTCSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVG 246
Query: 900 ADNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNC 959
D G G + L PK+ G + +L S + H ++L+ Q+ G
Sbjct: 247 PDGDFSSPGSGCYM-LLDPKNARPGQKAVLLSPVSLSSGCLSFSFH---YILRGQSPG-- 300
Query: 960 SVSKLEARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVG 999
+ + A +L S+ F NW + + TAVG
Sbjct: 301 AALHIYASVLG--SIRKHTLFSGQPGPNWQAVSVNYTAVG 338
>gi|27881494 zonadhesin isoform 6 [Homo sapiens]
Length = 2721
Score = 81.3 bits (199), Expect = 7e-15
Identities = 139/612 (22%), Positives = 215/612 (35%), Gaps = 138/612 (22%)
Query: 229 QCNFETG---ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQ 285
QC+FE +C+W Q + DD DW R GP+PT +TG G +G YL++ES+
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNG--EGSYLHMESNSFH 97
Query: 286 AFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQ---LLWQIFG 342
A LLSP L + F +HMFG + + + S G+ +LW+ +
Sbjct: 98 R-GGVARLLSPDL--WEQGPLCVHFAHHMFGLS-WGAQLRLLLLSGEEGRRPDVLWKHWN 153
Query: 343 NQGNRWIRKHLNISS--RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADLPT 400
Q W+ + + + P +++ E + G DIA+D LS
Sbjct: 154 TQRPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS----------------- 196
Query: 401 PPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEVCSFEKR 460
I R + + MQ C F D P+
Sbjct: 197 --------------------IRRGSCNRVCMMQTCSF--DIPN----------------- 217
Query: 461 SLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSVDHTQNTTDGWYLYADSSNG 520
LC W + ++ +W G S G+ P D + + G Y+ D N
Sbjct: 218 DLCDW------TWIPTASGAKWTQKKGSS---GKPGVGPDGDFS-SPGSGCYMLLDPKNA 267
Query: 521 KFGDTADILTPIISLTGPKCTLVFWTHMNGATVG-SLQVLIKKDNVTSKLWAQTGQQGAQ 579
+ G A +L+P +SL+ + F + G + G +L + K +GQ G
Sbjct: 268 RPGQKAVLLSP-VSLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLFSGQPGPN 326
Query: 580 WKRAEVFLGIRSHTQIVFRAKRGISYIGDVAVDDISFQDCSPLLSPERKCTDHEFMCANK 639
W+ V Q G + VAVD S C
Sbjct: 327 WQAVSVNYTAVGRIQFAVVGVFGKTPEPAVAVDATSIAPCG------------------- 367
Query: 640 HCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE---FDLCSWKQEKDEDFDWNLKAS 696
+CDFE C W Q + W L
Sbjct: 368 ---------------------------EGFPQCDFEDNAHPFCDWVQTSGDGGHWALGHK 400
Query: 697 SIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSPVISKRSKNCKIIFHYHMY 756
+ P G PA N+ GHYI++ + Q ++ R+ S C + F YHMY
Sbjct: 401 NGPVHGMGPAGG--FPNAGGHYIYLEADEFSQAGQSVRLVSRPFCAPGDIC-VEFAYHMY 457
Query: 757 GNGIGA-LTLMQVSVTNQTKVLLNLTV-EQGNFWRREELSLFG--DEDFQLKFEGRVGKG 812
G G G L L+ S + L V Q +W+ +++ + QL F+G G
Sbjct: 458 GLGEGTMLELLLGSPAGSPPIPLWKRVGSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSN 517
Query: 813 QRGDIALDDIVL 824
+A+ I++
Sbjct: 518 TASVVAMGFILI 529
Score = 52.4 bits (124), Expect = 3e-06
Identities = 87/385 (22%), Positives = 142/385 (36%), Gaps = 63/385 (16%)
Query: 444 KSDEASCVMEVCSFEK--RSLCKWYQPIPVHLLQDSNTFRWGLGNGISIHHGEENHRPSV 501
+S + V+ C FE + LC W Q + D + G + G P+
Sbjct: 30 RSSRDNYVLTQCDFEDDAKPLCDWSQ-----VSADDEDWVRASGPSPTGSTGAPGGYPN- 83
Query: 502 DHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGS-LQVLI 560
+G YL+ +S++ G A +L+P + GP C + F HM G + G+ L++L+
Sbjct: 84 ------GEGSYLHMESNSFHRGGVARLLSPDLWEQGPLC-VHFAHHMFGLSWGAQLRLLL 136
Query: 561 ---KKDNVTSKLWAQTGQQGAQWKRAEVFL--GIRSHTQIVFRAKRGISYIGDVAVDDIS 615
++ LW Q W V + G T+++F RG + D+A+D +S
Sbjct: 137 LSGEEGRRPDVLWKHWNTQRPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALDALS 196
Query: 616 FQDCSPLLSPERKCTDHEFMCANKHCIAKDKLCDFVNDCADNSDETTFICRTSSGRCDFE 675
+ S N+ C+ + D ND D T+I S +
Sbjct: 197 IRRGS----------------CNRVCMMQTCSFDIPNDLCD----WTWIPTASGAK---- 232
Query: 676 FDLCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARI 735
W K S G P D + SG Y+ ++ +P + A +
Sbjct: 233 ---------------WTQKKGSSGKPGVGPDGDFS-SPGSGCYMLLDPK-NARPGQKAVL 275
Query: 736 SSPVISKRSKNCKIIFHYHMYGNGIGALTLMQVSVTNQTKVLLNLTVEQGNFWRREELSL 795
SPV S S FHY + G GA + SV + + + G W+ ++
Sbjct: 276 LSPV-SLSSGCLSFSFHYILRGQSPGAALHIYASVLGSIRKHTLFSGQPGPNWQAVSVNY 334
Query: 796 FGDEDFQLKFEGRVGKGQRGDIALD 820
Q G GK +A+D
Sbjct: 335 TAVGRIQFAVVGVFGKTPEPAVAVD 359
Score = 48.9 bits (115), Expect = 4e-05
Identities = 49/194 (25%), Positives = 75/194 (38%), Gaps = 23/194 (11%)
Query: 229 QCNFETG---ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSE-P 284
QC+FE C+W Q + D W P GP A GHY+Y+E+ E
Sbjct: 372 QCDFEDNAHPFCDWVQTSGDGGHWALGHKNGPVHGMGPA--GGFPNAGGHYIYLEADEFS 429
Query: 285 QAFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWSDSRGQ---LLWQIF 341
QA Q + P D F YHM+G + + + + G LW+
Sbjct: 430 QAGQSVRLVSRPFCAPGD---ICVEFAYHMYG--LGEGTMLELLLGSPAGSPPIPLWKRV 484
Query: 342 GNQGNRWIRKHLNISS--RQPFQILVEASVGDGFTGDIAIDDLSFMDCTLYPGNLPADL- 398
G+Q W + + S +QP Q++ + G +A+ + + PG P +
Sbjct: 485 GSQRPYWQNTSVTVPSGHQQPMQLIFKGIQGSNTASVVAMGFI-----LINPGTCPVKVL 539
Query: 399 -PTPPETSVPVTLP 411
PP + V T P
Sbjct: 540 PELPPVSPVSSTGP 553
Score = 46.6 bits (109), Expect = 2e-04
Identities = 83/340 (24%), Positives = 124/340 (36%), Gaps = 52/340 (15%)
Query: 671 RCDFEFD---LCSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQ 727
+CDFE D LC W Q +D DW + P T + G S ++ NS
Sbjct: 40 QCDFEDDAKPLCDWSQVSADDEDWVRASGPSPTGSTGAPGGYPNGEGSYLHMESNSF--- 96
Query: 728 QPMRAARISSPVISKRSKNCKIIFHYHMYGNGIGA---LTLMQVSVTNQTKVLLNLTVEQ 784
AR+ SP + ++ C + F +HM+G GA L L+ + VL Q
Sbjct: 97 HRGGVARLLSPDLWEQGPLC-VHFAHHMFGLSWGAQLRLLLLSGEEGRRPDVLWKHWNTQ 155
Query: 785 GNFWRREELSLFGDEDF--QLKFEGRVGKGQRGDIALDDIVLTENCLSLHDSVQEELAVP 842
W +++ +L FEG G DIALD A+
Sbjct: 156 RPSWMLTTVTVPAGFTLPTRLMFEGTRGSTAYLDIALD-------------------ALS 196
Query: 843 LPTGFCPLGYRECHNGKCYRLEQSCNF---VDNCGDNTGENKCGSSCTFEKGWCGWQNSQ 899
+ G C N C + Q+C+F D C G+ T +KG G
Sbjct: 197 IRRGSC--------NRVC--MMQTCSFDIPNDLCDWTWIPTASGAKWTQKKGSSGKPGVG 246
Query: 900 ADNFDWVLGVGSHQSLRPPKDHTLGNENAILLMRRHKYPIRSVNLHTVKHVLKAQTVGNC 959
D G G + L PK+ G + +L S + H ++L+ Q+ G
Sbjct: 247 PDGDFSSPGSGCYM-LLDPKNARPGQKAVLLSPVSLSSGCLSFSFH---YILRGQSPG-- 300
Query: 960 SVSKLEARLLDFLSVPNENTFGSSDHMNWHFMYLEATAVG 999
+ + A +L S+ F NW + + TAVG
Sbjct: 301 AALHIYASVLG--SIRKHTLFSGQPGPNWQAVSVNYTAVG 338
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 79.3 bits (194), Expect = 3e-14
Identities = 46/122 (37%), Positives = 58/122 (47%), Gaps = 10/122 (8%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPPLCSNMEFPCSTDECIPS 1397
C +F C + CVPL+ +CD DC DGSDE +C + P + C +P
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP-----CTQKGQCPPPPGLP- 107
Query: 1398 LLLCDGVPDCHFNEDELI--CSNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDES 1455
C GV DC D+ + CS +C G L C S+ CIP RCDG DC D DE
Sbjct: 108 -CPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD-SSDEL 165
Query: 1456 SC 1457
C
Sbjct: 166 GC 167
Score = 48.5 bits (114), Expect = 5e-05
Identities = 19/43 (44%), Positives = 25/43 (58%)
Query: 1338 CEADQFSCIYTLQCVPLSGKCDGHEDCIDGSDEMDCPLNPTPP 1380
C A + C + C+PL+ +CDGH DC D SDE+ C N P
Sbjct: 132 CLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDELGCGTNEILP 174
Score = 45.1 bits (105), Expect = 5e-04
Identities = 21/62 (33%), Positives = 31/62 (50%), Gaps = 3/62 (4%)
Query: 395 PADLPTPPETSVPVTLPPHNCTDNEFICRSDGHCIEKMQKCDFKYDCPDKSDEASCVMEV 454
P PT + + P + +C +F CR+ G C+ +CD DC D SDE C +E
Sbjct: 37 PLSTPTSAQAAGPSS---GSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEP 93
Query: 455 CS 456
C+
Sbjct: 94 CT 95
Score = 35.8 bits (81), Expect = 0.33
Identities = 22/80 (27%), Positives = 25/80 (31%), Gaps = 15/80 (18%)
Query: 386 DCTLYPGNLPADLPTPPETSVPVT---------------LPPHNCTDNEFICRSDGHCIE 430
+C + P P PP P T C E C CI
Sbjct: 88 ECRIEPCTQKGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIP 147
Query: 431 KMQKCDFKYDCPDKSDEASC 450
+CD DCPD SDE C
Sbjct: 148 LTWRCDGHPDCPDSSDELGC 167
Score = 32.3 bits (72), Expect = 3.6
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 1/41 (2%)
Query: 1417 SNKSCSNGALVCASSNSCIPAHQRCDGFADCMDFQLDESSC 1457
S+ SC C +S C+P RCD DC D DE C
Sbjct: 50 SSGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGS-DEEEC 89
>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
Length = 923
Score = 75.1 bits (183), Expect = 5e-13
Identities = 48/160 (30%), Positives = 81/160 (50%), Gaps = 16/160 (10%)
Query: 230 CNFETG----ICNWEQDAKDDFDWTRNQGPTPTLNTGPMKDNTLGTAKGHYLYIESSEPQ 285
C F G C+WE D W+ T TGP++D+T G+++Y ++ E Q
Sbjct: 650 CEFGWGSHKTFCHWEHDNHVQLKWS-----VLTSKTGPIQDHT---GDGNFIYSQADENQ 701
Query: 286 AFQDSAALLSPILNATDTKGCTFRFYYHMFGKRIYRLAIYQRIWS-DSRGQLLWQIFGNQ 344
+ A L+SP++ + ++ C F+YHM G + L + R + QL+W G+Q
Sbjct: 702 KGK-VARLVSPVVYSQNSAHC-MTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQ 759
Query: 345 GNRWIRKHLNI-SSRQPFQILVEASVGDGFTGDIAIDDLS 383
G+ W + + S + +Q++ E +G G G IA+DD+S
Sbjct: 760 GDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDIS 799
Score = 68.6 bits (166), Expect = 5e-11
Identities = 41/141 (29%), Positives = 71/141 (50%), Gaps = 15/141 (10%)
Query: 499 PSVDHTQNTTDGWYLYADSSNGKFGDTADILTPIISLTGPKCTLVFWTHMNGATVGSLQV 558
P DHT DG ++Y+ + + G A +++P++ + FW HM+G+ VG+L+V
Sbjct: 682 PIQDHTG---DGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRV 738
Query: 559 LI---KKDNVTSKLWAQTGQQGAQWKRAEVFL--GIRSHTQIVFRAKRGISYIGDVAVDD 613
+ K + +W G QG WK V L ++ + Q++F + G +G +AVDD
Sbjct: 739 KLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLY-QVIFEGEIGKGNLGGIAVDD 797
Query: 614 ISF------QDCSPLLSPERK 628
IS +DC+ ++K
Sbjct: 798 ISINNHISQEDCAKPADLDKK 818
Score = 63.2 bits (152), Expect = 2e-09
Identities = 45/153 (29%), Positives = 78/153 (50%), Gaps = 14/153 (9%)
Query: 679 CSWKQEKDEDFDWNLKASSIPAAGTEPAADHTLGNSSGHYIFINSLFPQQPMRAARISSP 738
C W+ + W++ S T P DHT G++I+ + Q + AR+ SP
Sbjct: 661 CHWEHDNHVQLKWSVLTSK-----TGPIQDHT---GDGNFIY-SQADENQKGKVARLVSP 711
Query: 739 VI-SKRSKNCKIIFHYHMYGNGIGALTL-MQVSVTNQTKVLLNLTV-EQGNFWRREELSL 795
V+ S+ S +C + F YHM G+ +G L + ++ + L+ + + QG+ W+ + L
Sbjct: 712 VVYSQNSAHC-MTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLL 770
Query: 796 FGD-EDFQLKFEGRVGKGQRGDIALDDIVLTEN 827
+ +Q+ FEG +GKG G IA+DDI + +
Sbjct: 771 HKSLKLYQVIFEGEIGKGNLGGIAVDDISINNH 803
Score = 52.8 bits (125), Expect = 3e-06
Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 13/160 (8%)
Query: 1165 NFETSSGNWTTACSLTQDSEDDLDWAIGSRIPAKALIPDSDHTPGSGQHFLYVNSSGSKE 1224
N E G+ T C D+ L W++ + P DHT G G +F+Y + +++
Sbjct: 649 NCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTG----PIQDHT-GDG-NFIYSQADENQK 702
Query: 1225 GSVARITTSKSFPASLGMCTVRFWFYMIDPRSMGILKV---YTIEESGLNILVWSVIGNK 1281
G VAR+ + + + C + FW++M +G L+V Y E + LVW IG++
Sbjct: 703 GKVARLVSPVVYSQNSAHC-MTFWYHMSGSH-VGTLRVKLRYQKPEE-YDQLVWMAIGHQ 759
Query: 1282 RTGWTYGSVPL-SSNSPFKVAFEADLDGNEDIFIALDDIS 1320
W G V L S ++V FE ++ IA+DDIS
Sbjct: 760 GDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDIS 799
Score = 50.1 bits (118), Expect = 2e-05
Identities = 42/178 (23%), Positives = 81/178 (45%), Gaps = 21/178 (11%)
Query: 8 ILSSMKIWVSKCDFEANS----CDWFEAISGDHFDWIRSSQSELSADFEHQAPPRDHSLN 63
I S + C+F S C W +H + ++ S L++ P +DH+
Sbjct: 639 IQSEFPTYGFNCEFGWGSHKTFCHW------EHDNHVQLKWSVLTSK---TGPIQDHT-- 687
Query: 64 ASQGHFMFILKKSSSLWQVAKLQSPT-FSQTGPGCILSFWFYNYGLSVGAAELQLHMENS 122
G+F++ + +VA+L SP +SQ C ++FW++ G VG ++L +
Sbjct: 688 -GDGNFIYSQADENQKGKVARLVSPVVYSQNSAHC-MTFWYHMSGSHVGTLRVKLRYQKP 745
Query: 123 HD-STVIWRVLYNQGKQWLEATIQLGRLSQPFHLSLD-KVSLGIYDGVSAIDDIRFEN 178
+ ++W + +QG W E + L + + + + + ++ G G+ A+DDI N
Sbjct: 746 EEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGI-AVDDISINN 802
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.440
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,350,008
Number of Sequences: 37866
Number of extensions: 3395393
Number of successful extensions: 10619
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 7761
Number of HSP's gapped (non-prelim): 1831
length of query: 1542
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1427
effective length of database: 13,892,928
effective search space: 19825208256
effective search space used: 19825208256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.