Search of human proteins with 119220554

Search of human proteins with 119220554

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|119220554 serine palmitoyltransferase, long chain base
subunit 3 [Homo sapiens]
         (552 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|119220554 serine palmitoyltransferase, long chain base subuni...  1110   0.0  
gi|4758668 serine palmitoyltransferase, long chain base subunit ...   777   0.0  
gi|7657118 glycine C-acetyltransferase precursor [Homo sapiens]       178   1e-44
gi|83977444 5-aminolevulinate synthase 2 isoform c precursor [Ho...   172   5e-43
gi|83977440 5-aminolevulinate synthase 2 isoform b precursor [Ho...   172   5e-43
gi|83977442 5-aminolevulinate synthase 2 isoform a precursor [Ho...   172   5e-43
gi|5454084 serine palmitoyltransferase subunit 1 isoform a [Homo...   164   1e-40
gi|40316939 5-aminolevulinate synthase 1 [Homo sapiens]               144   2e-34
gi|4502025 5-aminolevulinate synthase 1 [Homo sapiens]                144   2e-34
gi|62420888 dipeptidyl peptidase 7 preproprotein [Homo sapiens]        30   5.8  
gi|72534692 5'-nucleotidase domain containing 3 [Homo sapiens]         30   5.8  
gi|4504201 general transcription factor IIH, polypeptide 4, 52kD...    29   9.8  

>gi|119220554 serine palmitoyltransferase, long chain base subunit 3
           [Homo sapiens]
          Length = 552

 Score = 1110 bits (2872), Expect = 0.0
 Identities = 552/552 (100%), Positives = 552/552 (100%)

Query: 1   MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPL 60
           MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPL
Sbjct: 1   MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPL 60

Query: 61  HVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYM 120
           HVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYM
Sbjct: 61  HVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYM 120

Query: 121 RIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDES 180
           RIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDES
Sbjct: 121 RIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDES 180

Query: 181 MRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPA 240
           MRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPA
Sbjct: 181 MRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPA 240

Query: 241 LVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWK 300
           LVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWK
Sbjct: 241 LVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWK 300

Query: 301 KILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPH 360
           KILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPH
Sbjct: 301 KILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPH 360

Query: 361 EVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMG 420
           EVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMG
Sbjct: 361 EVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMG 420

Query: 421 LDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLE 480
           LDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLE
Sbjct: 421 LDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLE 480

Query: 481 KKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARP 540
           KKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARP
Sbjct: 481 KKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARP 540

Query: 541 ELYDETSFELED 552
           ELYDETSFELED
Sbjct: 541 ELYDETSFELED 552


>gi|4758668 serine palmitoyltransferase, long chain base subunit 2
           [Homo sapiens]
          Length = 562

 Score =  777 bits (2007), Expect = 0.0
 Identities = 383/546 (70%), Positives = 449/546 (82%), Gaps = 8/546 (1%)

Query: 7   GAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPLHVMVFT 66
           G V NG++ N   +S+ + +      G +    QNG    Y +   E+FEE P+ V V T
Sbjct: 18  GCVANGEVRNGYVRSSAAAAAAAAA-GQIHHVTQNGG--LYKRPFNEAFEETPMLVAVLT 74

Query: 67  YMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYMRIRDNW 126
           Y+GYG+ TLFGYLRDFLR W IEKC+ A ER+EQKDFV LYQDFENFYTRNLYMRIRDNW
Sbjct: 75  YVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNW 134

Query: 127 NRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKD 186
           NRPICS PG   D+MER S DYNW+F++TG +IK VINMGSYN+LG A            
Sbjct: 135 NRPICSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAK 194

Query: 187 VLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPALVGKGC 246
           VLE YG GV STR E+G LDKH+ELE+LVA+FL VEAAM +GMGFATNSMNIPALVGKGC
Sbjct: 195 VLEEYGAGVCSTRQEIGNLDKHEELEELVARFLGVEAAMAYGMGFATNSMNIPALVGKGC 254

Query: 247 LILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILV 306
           LILSDELNH SLVLGARLSGATIRIFKHNN QSLEKLL+DA++YGQPRTRR WKKILILV
Sbjct: 255 LILSDELNHASLVLGARLSGATIRIFKHNNMQSLEKLLKDAIVYGQPRTRRPWKKILILV 314

Query: 307 EGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLM 366
           EG+YSMEGSIV LP++IALKKKYKAYLY+DEAHSIGA+GPTGRGV E+FGLDP +VDV+M
Sbjct: 315 EGIYSMEGSIVRLPEVIALKKKYKAYLYLDEAHSIGALGPTGRGVVEYFGLDPEDVDVMM 374

Query: 367 GTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQ 426
           GTFTKSFGASGGYI G+K+L+DYLR HSHSAVYA+S+SPP+ EQII S+K IMG DGT+ 
Sbjct: 375 GTFTKSFGASGGYIGGKKELIDYLRTHSHSAVYATSLSPPVVEQIITSMKCIMGQDGTSL 434

Query: 427 GLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKKIGVV 486
           G + VQQLA+NTRYFR+RL+EMGFIIYGNE++ VVPL+LYMP K+ AF R ML++ IGVV
Sbjct: 435 GKECVQQLAENTRYFRRRLKEMGFIIYGNEDSPVVPLMLYMPAKIGAFGREMLKRNIGVV 494

Query: 487 VVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSA---RPELY 543
           VVGFPATP+ E+RARFC+SAAHT+E+LDT L+ +DE+GDLLQLKYSRH+      RP  +
Sbjct: 495 VVGFPATPIIESRARFCLSAAHTKEILDTALKEIDEVGDLLQLKYSRHRLVPLLDRP--F 552

Query: 544 DETSFE 549
           DET++E
Sbjct: 553 DETTYE 558


>gi|7657118 glycine C-acetyltransferase precursor [Homo sapiens]
          Length = 419

 Score =  178 bits (452), Expect = 1e-44
 Identities = 117/366 (31%), Positives = 194/366 (53%), Gaps = 19/366 (5%)

Query: 162 VINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNV 221
           ++N  + N+LGL++ + E ++     LE +G G++S R   GT   HK LE  +A+F   
Sbjct: 67  ILNFCANNYLGLSS-HPEVIQAGLQALEEFGAGLSSVRFICGTQSIHKNLEAKIARFHQR 125

Query: 222 EAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLE 281
           E A+++   +  N+    AL+     +LSDELNH S++ G RL  A    ++H +   LE
Sbjct: 126 EDAILYPSCYDANAGLFEALLTPEDAVLSDELNHASIIDGIRLCKAHKYRYRHLDMADLE 185

Query: 282 KLLRDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSI 341
             L++A         +  +  L+  +G +SM+G I  L +I  L  +Y A +++DE H+ 
Sbjct: 186 AKLQEA---------QKHRLRLVATDGAFSMDGDIAPLQEICCLASRYGALVFMDECHAT 236

Query: 342 GAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSF-GASGGYIAGRKDLVDYLRVHSHSAVYA 400
           G +GPTGRG  E  G+   +V ++  T  K+  GASGGY  G   LV  LR  +   +++
Sbjct: 237 GFLGPTGRGTDELLGV-MDQVTIINSTLGKALGGASGGYTTGPGPLVSLLRQRARPYLFS 295

Query: 401 SSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASV 460
           +S+ P +     ++L L+MG +        VQ +A  T+ FR +++  GF I G  +  +
Sbjct: 296 NSLPPAVVGCASKALDLLMGSNTI------VQSMAAKTQRFRSKMEAAGFTISGASH-PI 348

Query: 461 VPLLLYMPGKVAAFARHMLEKKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEAL 520
            P++L      +  A  ML++ I V+   +P  P  +AR R  +SA H+ E +D  +EA 
Sbjct: 349 CPVMLGDARLASRMADDMLKRGIFVIGFSYPVVPKGKARIRVQISAVHSEEDIDRCVEAF 408

Query: 521 DEMGDL 526
            E+G L
Sbjct: 409 VEVGRL 414


>gi|83977444 5-aminolevulinate synthase 2 isoform c precursor [Homo
           sapiens]
          Length = 574

 Score =  172 bits (437), Expect = 5e-43
 Identities = 113/389 (29%), Positives = 204/389 (52%), Gaps = 21/389 (5%)

Query: 137 LFDLMERVSDDYNWTFRFTGRVI--KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTG 194
           +F  + R +D Y +   F+   +  KDV    S ++LG++ ++ + ++  ++ L+ +G G
Sbjct: 151 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS-RHPQVLQATQETLQRHGAG 209

Query: 195 VASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPAL--VGKGCLILSDE 252
              TR+  GT   H ELE  +A+    ++A++F   F  N   +  L  +  GC I SD 
Sbjct: 210 AGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDA 269

Query: 253 LNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSM 312
            NH S++ G R SGA   +F+HN+   L+KLL  +     P+  +     ++  E V+SM
Sbjct: 270 GNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----NPKIPK-----IVAFETVHSM 320

Query: 313 EGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS 372
           +G+I  L ++  +  +Y A  ++DE H++G  G  G G+ E  G+  H++D++ GT  K+
Sbjct: 321 DGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDIISGTLGKA 379

Query: 373 FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQ 432
           FG  GGYIA  +DLVD +R ++   ++ +S+ P +    + S++L+ G +G  Q L+R  
Sbjct: 380 FGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAH 437

Query: 433 QLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKK-IGVVVVGFP 491
           Q  +N ++ RQ L + G  +     + ++P+ +      +     +L K  I V  + +P
Sbjct: 438 Q--RNVKHMRQLLMDRGLPVIPCP-SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYP 494

Query: 492 ATPLAEARARFCVSAAHTREMLDTVLEAL 520
             P  E   R   S  H+ +M++  +E L
Sbjct: 495 TVPRGEELLRLAPSPHHSPQMMEDFVEKL 523


>gi|83977440 5-aminolevulinate synthase 2 isoform b precursor [Homo
           sapiens]
          Length = 550

 Score =  172 bits (437), Expect = 5e-43
 Identities = 113/389 (29%), Positives = 204/389 (52%), Gaps = 21/389 (5%)

Query: 137 LFDLMERVSDDYNWTFRFTGRVI--KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTG 194
           +F  + R +D Y +   F+   +  KDV    S ++LG++ ++ + ++  ++ L+ +G G
Sbjct: 127 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS-RHPQVLQATQETLQRHGAG 185

Query: 195 VASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPAL--VGKGCLILSDE 252
              TR+  GT   H ELE  +A+    ++A++F   F  N   +  L  +  GC I SD 
Sbjct: 186 AGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDA 245

Query: 253 LNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSM 312
            NH S++ G R SGA   +F+HN+   L+KLL  +     P+  +     ++  E V+SM
Sbjct: 246 GNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----NPKIPK-----IVAFETVHSM 296

Query: 313 EGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS 372
           +G+I  L ++  +  +Y A  ++DE H++G  G  G G+ E  G+  H++D++ GT  K+
Sbjct: 297 DGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDIISGTLGKA 355

Query: 373 FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQ 432
           FG  GGYIA  +DLVD +R ++   ++ +S+ P +    + S++L+ G +G  Q L+R  
Sbjct: 356 FGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAH 413

Query: 433 QLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKK-IGVVVVGFP 491
           Q  +N ++ RQ L + G  +     + ++P+ +      +     +L K  I V  + +P
Sbjct: 414 Q--RNVKHMRQLLMDRGLPVIPCP-SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYP 470

Query: 492 ATPLAEARARFCVSAAHTREMLDTVLEAL 520
             P  E   R   S  H+ +M++  +E L
Sbjct: 471 TVPRGEELLRLAPSPHHSPQMMEDFVEKL 499


>gi|83977442 5-aminolevulinate synthase 2 isoform a precursor [Homo
           sapiens]
          Length = 587

 Score =  172 bits (437), Expect = 5e-43
 Identities = 113/389 (29%), Positives = 204/389 (52%), Gaps = 21/389 (5%)

Query: 137 LFDLMERVSDDYNWTFRFTGRVI--KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTG 194
           +F  + R +D Y +   F+   +  KDV    S ++LG++ ++ + ++  ++ L+ +G G
Sbjct: 164 VFKTVNRWADAYPFAQHFSEASVASKDVSVWCSNDYLGMS-RHPQVLQATQETLQRHGAG 222

Query: 195 VASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPAL--VGKGCLILSDE 252
              TR+  GT   H ELE  +A+    ++A++F   F  N   +  L  +  GC I SD 
Sbjct: 223 AGGTRNISGTSKFHVELEQELAELHQKDSALLFSSCFVANDSTLFTLAKILPGCEIYSDA 282

Query: 253 LNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWKKILILVEGVYSM 312
            NH S++ G R SGA   +F+HN+   L+KLL  +     P+  +     ++  E V+SM
Sbjct: 283 GNHASMIQGIRNSGAAKFVFRHNDPDHLKKLLEKS----NPKIPK-----IVAFETVHSM 333

Query: 313 EGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKS 372
           +G+I  L ++  +  +Y A  ++DE H++G  G  G G+ E  G+  H++D++ GT  K+
Sbjct: 334 DGAICPLEELCDVSHQYGALTFVDEVHAVGLYGSRGAGIGERDGI-MHKIDIISGTLGKA 392

Query: 373 FGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMGLDGTTQGLQRVQ 432
           FG  GGYIA  +DLVD +R ++   ++ +S+ P +    + S++L+ G +G  Q L+R  
Sbjct: 393 FGCVGGYIASTRDLVDMVRSYAAGFIFTTSLPPMVLSGALESVRLLKGEEG--QALRRAH 450

Query: 433 QLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLEKK-IGVVVVGFP 491
           Q  +N ++ RQ L + G  +     + ++P+ +      +     +L K  I V  + +P
Sbjct: 451 Q--RNVKHMRQLLMDRGLPVIPCP-SHIIPIRVGNAALNSKLCDLLLSKHGIYVQAINYP 507

Query: 492 ATPLAEARARFCVSAAHTREMLDTVLEAL 520
             P  E   R   S  H+ +M++  +E L
Sbjct: 508 TVPRGEELLRLAPSPHHSPQMMEDFVEKL 536


>gi|5454084 serine palmitoyltransferase subunit 1 isoform a [Homo
           sapiens]
          Length = 473

 Score =  164 bits (416), Expect = 1e-40
 Identities = 88/260 (33%), Positives = 148/260 (56%), Gaps = 2/260 (0%)

Query: 160 KDVINMGSYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFL 219
           K+ IN  S+NFLGL          +   L+ YG G    R   GT D H +LED +AKF+
Sbjct: 98  KECINFASFNFLGLLDNPRVKAAALAS-LKKYGVGTCGPRGFYGTFDVHLDLEDRLAKFM 156

Query: 220 NVEAAMVFGMGFATNSMNIPALVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQS 279
             E A+++  GFAT +  IPA   +G ++  D     ++  G + S + I++FKHN+   
Sbjct: 157 KTEEAIIYSYGFATIASAIPAYSKRGDIVFVDRAACFAIQKGLQASRSDIKLFKHNDMAD 216

Query: 280 LEKLLRDAVIYGQPRTRRAW-KKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEA 338
           LE+LL++  I  Q   R+A   +  I+VEG+Y   G+I  LP+++ LK KYKA ++++E+
Sbjct: 217 LERLLKEQEIEDQKNPRKARVTRRFIVVEGLYMNTGTICPLPELVKLKYKYKARIFLEES 276

Query: 339 HSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAV 398
            S G +G  GRGVTE +G++  ++D++      +  + GG+  GR  ++D+ R+      
Sbjct: 277 LSFGVLGEHGRGVTEHYGINIDDIDLISANMENALASIGGFCCGRSFVIDHQRLSGQGYC 336

Query: 399 YASSMSPPIAEQIIRSLKLI 418
           +++S+ P +A   I +L ++
Sbjct: 337 FSASLPPLLAAAAIEALNIM 356


>gi|40316939 5-aminolevulinate synthase 1 [Homo sapiens]
          Length = 640

 Score =  144 bits (363), Expect = 2e-34
 Identities = 98/357 (27%), Positives = 179/357 (50%), Gaps = 19/357 (5%)

Query: 167 SYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMV 226
           S ++LG++ ++      + D L+ +G G   TR+  GT   H +LE  +A     +AA++
Sbjct: 250 SNDYLGMS-RHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALL 308

Query: 227 FGMGFATNSMNIPALVGK--GCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLL 284
           F   F  N   +  L     GC I SD  NH S++ G R S     IF+HN+   L +LL
Sbjct: 309 FSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELL 368

Query: 285 RDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAV 344
           +        R+  +  KI +  E V+SM+G++  L ++  +  ++ A  ++DE H++G  
Sbjct: 369 Q--------RSDPSVPKI-VAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 419

Query: 345 GPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMS 404
           G  G G+ +  G+ P ++D++ GT  K+FG  GGYIA    L+D +R ++   ++ +S+ 
Sbjct: 420 GARGGGIGDRDGVMP-KMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 478

Query: 405 PPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLL 464
           P +    + S++++   +G    L+R  Q  +N +  RQ L + G  +  +  + ++P+ 
Sbjct: 479 PMLLAGALESVRILKSAEGRV--LRRQHQ--RNVKLMRQMLMDAGLPVV-HCPSHIIPVR 533

Query: 465 LYMPGKVAAFARHMLEK-KIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEAL 520
           +    K       ++ +  I V  + +P  P  E   R   +  HT +M++  LE L
Sbjct: 534 VADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 590


>gi|4502025 5-aminolevulinate synthase 1 [Homo sapiens]
          Length = 640

 Score =  144 bits (363), Expect = 2e-34
 Identities = 98/357 (27%), Positives = 179/357 (50%), Gaps = 19/357 (5%)

Query: 167 SYNFLGLAAKYDESMRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMV 226
           S ++LG++ ++      + D L+ +G G   TR+  GT   H +LE  +A     +AA++
Sbjct: 250 SNDYLGMS-RHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALL 308

Query: 227 FGMGFATNSMNIPALVGK--GCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLL 284
           F   F  N   +  L     GC I SD  NH S++ G R S     IF+HN+   L +LL
Sbjct: 309 FSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELL 368

Query: 285 RDAVIYGQPRTRRAWKKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAV 344
           +        R+  +  KI +  E V+SM+G++  L ++  +  ++ A  ++DE H++G  
Sbjct: 369 Q--------RSDPSVPKI-VAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLY 419

Query: 345 GPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMS 404
           G  G G+ +  G+ P ++D++ GT  K+FG  GGYIA    L+D +R ++   ++ +S+ 
Sbjct: 420 GARGGGIGDRDGVMP-KMDIISGTLGKAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 478

Query: 405 PPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLL 464
           P +    + S++++   +G    L+R  Q  +N +  RQ L + G  +  +  + ++P+ 
Sbjct: 479 PMLLAGALESVRILKSAEGRV--LRRQHQ--RNVKLMRQMLMDAGLPVV-HCPSHIIPVR 533

Query: 465 LYMPGKVAAFARHMLEK-KIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEAL 520
           +    K       ++ +  I V  + +P  P  E   R   +  HT +M++  LE L
Sbjct: 534 VADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 590


>gi|62420888 dipeptidyl peptidase 7 preproprotein [Homo sapiens]
          Length = 492

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 15/42 (35%), Positives = 21/42 (50%)

Query: 415 LKLIMGLDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNE 456
           L L +GL G   G +R        R+F+QRL    F  +GN+
Sbjct: 10  LLLALGLRGLQAGARRAPDPGFQERFFQQRLDHFNFERFGNK 51


>gi|72534692 5'-nucleotidase domain containing 3 [Homo sapiens]
          Length = 548

 Score = 30.0 bits (66), Expect = 5.8
 Identities = 17/65 (26%), Positives = 33/65 (50%), Gaps = 5/65 (7%)

Query: 128 RPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDESMRTIKDV 187
           RP+C+APG   D+   + + Y    R T  ++  +++    N L   A +  +  ++ D+
Sbjct: 41  RPLCTAPGTAPDMKRYLWERYREAKRSTEELVPSIMS----NLLNPDAIFSNNEMSLSDI 96

Query: 188 LEVYG 192
            E+YG
Sbjct: 97  -EIYG 100


>gi|4504201 general transcription factor IIH, polypeptide 4, 52kDa
           [Homo sapiens]
          Length = 462

 Score = 29.3 bits (64), Expect = 9.8
 Identities = 35/180 (19%), Positives = 73/180 (40%), Gaps = 10/180 (5%)

Query: 280 LEKLLRDAVIYGQPRTRRAW--KKILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDE 337
           L+ L    +++ + R  R +   ++ I +    S  G  VH P  I ++  Y+ Y Y + 
Sbjct: 262 LQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTES 321

Query: 338 AHSIGAVGPTGRGVTEFFGLDPHEVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSA 397
              I  +      +  F    P+ V   +   +     + G  A  + ++ +LR  +H  
Sbjct: 322 ELQIALIALFSEMLYRF----PNMVVAQVTRESVQQAIASGITA--QQIIHFLRTRAHPV 375

Query: 398 VYASS-MSPPIAEQIIRSLKLIMGLDGTTQGLQRVQQLAK-NTRYFRQRLQEMGFIIYGN 455
           +   + + PP     IR  +L       T+G+   Q L++ +        +E+G +++ N
Sbjct: 376 MLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFEN 435


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.406 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,207,723
Number of Sequences: 37866
Number of extensions: 866068
Number of successful extensions: 1915
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 2
Number of HSP's that attempted gapping in prelim test: 1884
Number of HSP's gapped (non-prelim): 12
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.