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Search of human proteins with 118344456
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|118344456 UTP18, small subunit processome component [Homo
sapiens]
(556 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|118344456 UTP18, small subunit processome component [Homo sap... 1115 0.0
gi|13376840 WD repeat domain 61 [Homo sapiens] 57 6e-08
gi|16554629 WD repeat domain 5 [Homo sapiens] 54 4e-07
gi|16554627 WD repeat domain 5 [Homo sapiens] 54 4e-07
gi|23199987 WD repeat domain 5B [Homo sapiens] 49 9e-06
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 48 2e-05
gi|21541824 transducin-like enhancer protein 1 [Homo sapiens] 46 8e-05
gi|21071067 TBP-associated factor 5 [Homo sapiens] 46 1e-04
gi|26665869 WD repeat domain 51B [Homo sapiens] 46 1e-04
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens] 45 2e-04
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 44 4e-04
gi|55741849 WD repeat domain 22 [Homo sapiens] 43 7e-04
gi|55956788 nucleolin [Homo sapiens] 43 9e-04
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 43 9e-04
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 43 9e-04
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ... 43 9e-04
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ... 43 9e-04
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ... 43 9e-04
gi|223005859 WD repeat domain 67 isoform 1 [Homo sapiens] 42 0.001
gi|223005857 WD repeat domain 67 isoform 2 [Homo sapiens] 42 0.001
gi|53759148 retinoblastoma binding protein 5 [Homo sapiens] 42 0.001
gi|38327642 WD repeat domain 55 [Homo sapiens] 42 0.002
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ... 41 0.003
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ... 41 0.003
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ... 41 0.003
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s... 41 0.003
gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo ... 41 0.003
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 41 0.003
gi|30520335 WD repeat domain 49 [Homo sapiens] 41 0.003
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 41 0.003
>gi|118344456 UTP18, small subunit processome component [Homo
sapiens]
Length = 556
Score = 1115 bits (2883), Expect = 0.0
Identities = 556/556 (100%), Positives = 556/556 (100%)
Query: 1 MPPERRRRMKLDRRTGAKPKRKPGMRPDWKAGAGPGGPPQKPAPSSQRKPPARPSAAAAA 60
MPPERRRRMKLDRRTGAKPKRKPGMRPDWKAGAGPGGPPQKPAPSSQRKPPARPSAAAAA
Sbjct: 1 MPPERRRRMKLDRRTGAKPKRKPGMRPDWKAGAGPGGPPQKPAPSSQRKPPARPSAAAAA 60
Query: 61 IAVAAAEEERRLRQRNRLRLEEDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHED 120
IAVAAAEEERRLRQRNRLRLEEDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHED
Sbjct: 61 IAVAAAEEERRLRQRNRLRLEEDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHED 120
Query: 121 SGDSEVENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKK 180
SGDSEVENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKK
Sbjct: 121 SGDSEVENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKK 180
Query: 181 RLKEEFQHAMGGVPAWAETTKRKTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKN 240
RLKEEFQHAMGGVPAWAETTKRKTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKN
Sbjct: 181 RLKEEFQHAMGGVPAWAETTKRKTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKN 240
Query: 241 CQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFK 300
CQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFK
Sbjct: 241 CQHANAERPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFK 300
Query: 301 ACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLING 360
ACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLING
Sbjct: 301 ACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLING 360
Query: 361 IAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRF 420
IAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRF
Sbjct: 361 IAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRF 420
Query: 421 VDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLT 480
VDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLT
Sbjct: 421 VDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLT 480
Query: 481 FNPTTEILAIASEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGN 540
FNPTTEILAIASEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGN
Sbjct: 481 FNPTTEILAIASEKMKEAVRLVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGN 540
Query: 541 EKGKALMYRLHHYSDF 556
EKGKALMYRLHHYSDF
Sbjct: 541 EKGKALMYRLHHYSDF 556
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 56.6 bits (135), Expect = 6e-08
Identities = 50/200 (25%), Positives = 92/200 (46%), Gaps = 10/200 (5%)
Query: 256 SVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATST 315
++ F P +Q + V++F V+ + K S+ I +S +G+ LA+
Sbjct: 111 TLAFSPDSQYLATGTHVGKVNIFGVE--SGKKEYSLDTRGKFILSIAYSPDGK-YLASGA 167
Query: 316 HSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKEL 375
++ ++D+ GKL+ H + G I RS SPD L+ GY+ + ++ L
Sbjct: 168 IDGIINIFDIATGKLL--HTLEGHAMPI-RSLTFSPDSQLLVTASDDGYIKIYDVQHANL 224
Query: 376 IGSMKINGR-VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVD-EGSLYGLSIAT 433
G++ + V F D +SS D V VWDV +R C++ F D + ++G +
Sbjct: 225 AGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG--VKY 282
Query: 434 SRNGQYVACGSNCGVVNIYN 453
+ NG + + ++IY+
Sbjct: 283 NGNGSKIVSVGDDQEIHIYD 302
Score = 39.7 bits (91), Expect = 0.007
Identities = 38/160 (23%), Positives = 70/160 (43%), Gaps = 25/160 (15%)
Query: 399 ASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCL 458
+SS D + +WD+ + K + + +D G + ++A S + QY+A G++ G VNI+ +S
Sbjct: 81 SSSLDAHIRLWDLENGKQI-KSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK 139
Query: 459 QE----TNPKPIKAIMNLVTG--VTSLTFNPTTEILAIASEKMKEAVRLVHLPSCTVFSN 512
+E T K I +I G + S + I IA+ K+ + +P
Sbjct: 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP------- 192
Query: 513 FPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHH 552
+ ++ FSP S ++ G +Y + H
Sbjct: 193 -----------IRSLTFSPDSQLLVTASDDGYIKIYDVQH 221
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 53.9 bits (128), Expect = 4e-07
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 22/263 (8%)
Query: 205 SSDDESEEDEDDLLQRTGNFISTSTS----LPRGILKMKNCQHANAERPTVARISSVQFH 260
+++++ E E Q T + +T + P LK H A +SSV+F
Sbjct: 2 ATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKA-------VSSVKFS 54
Query: 261 PGAQIVMVAGLDNAVSLFQV-DGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKV 319
P + + + D + ++ DGK I + I +S++ +L +++ K
Sbjct: 55 PNGEWLASSSADKLIKIWGAYDGKFEKTISG---HKLGISDVAWSSDSN-LLVSASDDKT 110
Query: 320 LYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSM 379
L ++D+ +GK + ++G V +P + ++ + + +KT + + ++
Sbjct: 111 LKIWDVSSGKCLKT--LKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 380 KINGR-VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQ 438
+ V+A F+ D + +SS DG +WD S +CL +D+ + + S NG+
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227
Query: 439 YVACGSNCGVVNI--YNQDSCLQ 459
Y+ + + + Y++ CL+
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLK 250
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 53.9 bits (128), Expect = 4e-07
Identities = 54/263 (20%), Positives = 115/263 (43%), Gaps = 22/263 (8%)
Query: 205 SSDDESEEDEDDLLQRTGNFISTSTS----LPRGILKMKNCQHANAERPTVARISSVQFH 260
+++++ E E Q T + +T + P LK H A +SSV+F
Sbjct: 2 ATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKA-------VSSVKFS 54
Query: 261 PGAQIVMVAGLDNAVSLFQV-DGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKV 319
P + + + D + ++ DGK I + I +S++ +L +++ K
Sbjct: 55 PNGEWLASSSADKLIKIWGAYDGKFEKTISG---HKLGISDVAWSSDSN-LLVSASDDKT 110
Query: 320 LYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSM 379
L ++D+ +GK + ++G V +P + ++ + + +KT + + ++
Sbjct: 111 LKIWDVSSGKCLKT--LKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167
Query: 380 KINGR-VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQ 438
+ V+A F+ D + +SS DG +WD S +CL +D+ + + S NG+
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227
Query: 439 YVACGSNCGVVNI--YNQDSCLQ 459
Y+ + + + Y++ CL+
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLK 250
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 9e-06
Identities = 43/210 (20%), Positives = 96/210 (45%), Gaps = 11/210 (5%)
Query: 254 ISSVQFHPGAQIVMVAGLDNAVSLFQV-DGKTNPKIQSIYLERFPIFKACFSANGEEVLA 312
+SSV+F P + + + D + ++ DGK +++Y I +S++ +++
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE---KTLYGHNLEISDVAWSSDSSRLVS 100
Query: 313 TSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKT 372
S K L ++D+ +GK + ++G V +P + ++ + + +KT
Sbjct: 101 ASD-DKTLKLWDVRSGKCLKT--LKG-HSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 373 KELIGSMKINGR-VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSI 431
+ + ++ + V+A F+ + + S DG +WD S +CL VD+ + +
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 432 ATSRNGQYVACGSNCGVVNI--YNQDSCLQ 459
S NG+Y+ + + + Y++ CL+
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLK 246
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 48.1 bits (113), Expect = 2e-05
Identities = 39/190 (20%), Positives = 81/190 (42%), Gaps = 10/190 (5%)
Query: 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQ-VDGKTNPKIQSIYLERF-----PIFKACFSA 305
+ + +F P Q ++ +D + ++ GK ++ + F + CFS
Sbjct: 215 SHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSR 274
Query: 306 NGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYL 365
+ E+LAT + V+ + +G+ + + K V S D S +L +
Sbjct: 275 D-TEMLATGAQDGKIKVWKIQSGQCL--RRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 366 HLLAMKTKELIGSMKINGR-VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEG 424
+ +K+ + + + + V +TF+ D + ++S DG V +W++ + +C N F G
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLG 391
Query: 425 SLYGLSIATS 434
S G I +
Sbjct: 392 STAGTDITVN 401
Score = 43.1 bits (100), Expect = 7e-04
Identities = 26/116 (22%), Positives = 51/116 (43%), Gaps = 9/116 (7%)
Query: 350 SPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGR---------VAASTFSSDSKKVYAS 400
SPDG +L+ + G++ + T ++ +K + V FS D++ +
Sbjct: 223 SPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATG 282
Query: 401 SGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDS 456
+ DG++ VW + S +CL RF S ++ S++ + S + I+ S
Sbjct: 283 AQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKS 338
>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
Length = 770
Score = 46.2 bits (108), Expect = 8e-05
Identities = 49/185 (26%), Positives = 83/185 (44%), Gaps = 18/185 (9%)
Query: 328 GKLIPVHQVRGL-KEKIVRSFEVSPDGSFLLINGIAGYLHL--LAMKTKELIGSMKINGR 384
G PV Q+ L ++ +RS ++ PDG L++ G A L + LA T + + +
Sbjct: 516 GNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAP 575
Query: 385 VA-ASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLS-IATSRNGQYVAC 442
A S DSK ++ DG + VWD++++ + +F +G G S I S +G +
Sbjct: 576 ACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF--QGHTDGASCIDISNDGTKLWT 633
Query: 443 GSNCGVVNIYN--QDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVR 500
G V ++ + LQ+ + + + SL + PT E LA+ E V
Sbjct: 634 GGLDNTVRSWDLREGRQLQQ---------HDFTSQIFSLGYCPTGEWLAVGMESSNVEVL 684
Query: 501 LVHLP 505
V+ P
Sbjct: 685 HVNKP 689
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 45.8 bits (107), Expect = 1e-04
Identities = 42/172 (24%), Positives = 74/172 (43%), Gaps = 15/172 (8%)
Query: 382 NGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGL-SIATSRNGQYV 440
+G V ++FS D + +SS DG V +W + + CL + +G Y + S G Y
Sbjct: 543 SGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY--KGHNYPVWDTQFSPYGYYF 600
Query: 441 ACGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVR 500
G + V ++ D + +P++ + V F+P + +A S A R
Sbjct: 601 VSGGHDRVARLWATD------HYQPLRIFAGHLADVNCTRFHPNSNYVATGS-----ADR 649
Query: 501 LVHLPSCTVFSNFPVIKNKNISHVHTMDFSPRSGYFALGNEKGKALMYRLHH 552
V L + N I + +H++ FSP + A G G+ L++ + H
Sbjct: 650 TVRLWD-VLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH 700
Score = 33.9 bits (76), Expect = 0.40
Identities = 39/154 (25%), Positives = 64/154 (41%), Gaps = 7/154 (4%)
Query: 258 QFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHS 317
QF P + G D L+ D +I + +L + F N V AT +
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTR--FHPNSNYV-ATGSAD 648
Query: 318 KVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIG 377
+ + ++D+L G + + G K I S SP+G FL G + L + ++G
Sbjct: 649 RTVRLWDVLNGNCVRIFT--GHKGPI-HSLTFSPNGRFLATGATDGRVLLWDIGHGLMVG 705
Query: 378 SMK-INGRVAASTFSSDSKKVYASSGDGEVYVWD 410
+K V + FS D + + + S D V +WD
Sbjct: 706 ELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 45.8 bits (107), Expect = 1e-04
Identities = 53/205 (25%), Positives = 84/205 (40%), Gaps = 20/205 (9%)
Query: 254 ISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLAT 313
++SVQF P ++ A D V L+ D + K P+ FSA+G + LAT
Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLWIPDKR--GKFSEFKAHTAPVRSVDFSADG-QFLAT 119
Query: 314 STHSKVLYVYDMLAGKLI-----PVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLL 368
++ K + V+ M + + H VR K SPDG ++ + +
Sbjct: 120 ASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAK--------FSPDGRLIVSCSEDKTIKIW 171
Query: 369 AMKTKELIGSMKINGRVAASTFSSDSKKVYASSG-DGEVYVWDVNSRKCLNRF-VDEGSL 426
K+ + + + A + S AS+G D V VWDV K L + V G +
Sbjct: 172 DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGV 231
Query: 427 YGLSIATSRNGQYVACGSNCGVVNI 451
+S S G Y+ S+ G + I
Sbjct: 232 NCISFHPS--GNYLITASSDGTLKI 254
Score = 40.8 bits (94), Expect = 0.003
Identities = 44/207 (21%), Positives = 87/207 (42%), Gaps = 14/207 (6%)
Query: 344 VRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGR-VAASTFSSDSKKVYASSG 402
VRS + S DG FL + + +M + + S+ + V + FS D + + + S
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSE 164
Query: 403 DGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETN 462
D + +WD +++C+N F D + + + +G +A + V +++ N
Sbjct: 165 DKTIKIWDTTNKQCVNNFSDSVG-FANFVDFNPSGTCIASAGSDQTVKVWD-----VRVN 218
Query: 463 PKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVRLVHLPSCTVFSNFPVIKNKNIS 522
K ++ GV ++F+P+ L AS ++++ L + +
Sbjct: 219 -KLLQHYQVHSGGVNCISFHPSGNYLITASS--DGTLKILDLLEGRLIYTL----QGHTG 271
Query: 523 HVHTMDFSPRSGYFALGNEKGKALMYR 549
V T+ FS FA G + L++R
Sbjct: 272 PVFTVSFSKGGELFASGGADTQVLLWR 298
>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
Length = 773
Score = 44.7 bits (104), Expect = 2e-04
Identities = 49/185 (26%), Positives = 81/185 (43%), Gaps = 18/185 (9%)
Query: 328 GKLIPVHQVRGL-KEKIVRSFEVSPDGSFLLINGIAGYLHL--LAMKTKELIGSMKINGR 384
G PV Q+ L ++ +RS + PDG L++ G A L + LA T + + +
Sbjct: 519 GNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAP 578
Query: 385 VA-ASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLS-IATSRNGQYVAC 442
A S DSK ++ DG + VWD++++ + +F +G G S I S +G +
Sbjct: 579 ACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF--QGHTDGASCIDISNDGTKLWT 636
Query: 443 GSNCGVVNIYN--QDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVR 500
G V ++ + LQ+ + + + SL + PT E LA+ E V
Sbjct: 637 GGLDNTVRSWDLREGRQLQQ---------HDFTSQIFSLGYCPTGEWLAVGMENSNVEVL 687
Query: 501 LVHLP 505
V P
Sbjct: 688 HVTKP 692
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 43.9 bits (102), Expect = 4e-04
Identities = 44/194 (22%), Positives = 80/194 (41%), Gaps = 17/194 (8%)
Query: 222 GNFISTSTSLPRGILKMKNCQHANAERPTVA------RISSVQFHPGAQIVMVAGLDNAV 275
GNF+++S+ + K N+ER ++S++F P + ++ + D +
Sbjct: 448 GNFVASSS-----LDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTL 502
Query: 276 SLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKVLYVYDMLAGKLIPVHQ 335
S++ D +T QS+Y I A F G ++A+ V ++D KL+P+
Sbjct: 503 SIW--DARTGICEQSLYGHMHSINDAIFDPRGH-MIASCDACGVTKLWDFR--KLLPIVS 557
Query: 336 VRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAASTFSSDSK 395
+ + G L G +HLL +K+ E+ M FS D +
Sbjct: 558 I-DIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGE 616
Query: 396 KVYASSGDGEVYVW 409
+++ DG V W
Sbjct: 617 ILFSGGSDGTVRTW 630
>gi|55741849 WD repeat domain 22 [Homo sapiens]
Length = 942
Score = 43.1 bits (100), Expect = 7e-04
Identities = 34/112 (30%), Positives = 57/112 (50%), Gaps = 6/112 (5%)
Query: 390 FSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVV 449
F+S + KV++ D +V + DV S + L+ F E ++YGLS++ N A S+ G V
Sbjct: 109 FNSGNTKVFSGGNDEQVILHDVESSETLDVFAHEDAVYGLSVSPV-NDNIFASSSDDGRV 167
Query: 450 NIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVRL 501
I++ ++E+ + N + S+ FNP E +A+ KE V L
Sbjct: 168 LIWD----IRESPHGEPFCLANYPSAFHSVMFNP-VEPRLLATANSKEGVGL 214
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 42.7 bits (99), Expect = 9e-04
Identities = 47/210 (22%), Positives = 73/210 (34%), Gaps = 36/210 (17%)
Query: 17 AKPKRKPGMRPDWKAGAGPGGPPQKPA-----PSSQRKPP-----ARPSAAAAAIAVAAA 66
A P +K + P KA A P PA P + P A P AAI A
Sbjct: 75 ATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGA 134
Query: 67 EEERRLRQRNRLRLEEDKPAVERCLEELVFGDVENDEDALLRRLRGPRVQEHEDSGDSEV 126
+ + ++ + E+D + +E D + E A ++ E ED D E
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194
Query: 127 ENEAKGNFPPQKKPVWVDEEDEDEEMVDMMNNRFRKDMMKNASESKLSKDNLKKRLKEEF 186
DE+D+D+E D K +K+ K ++E
Sbjct: 195 -----------------DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDED 237
Query: 187 QHAMGGVPAWAETTKRKTSSDDESEEDEDD 216
+ E + + DDE +ED+DD
Sbjct: 238 EE---------EDDEDEDDDDDEDDEDDDD 258
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 42.7 bits (99), Expect = 9e-04
Identities = 39/170 (22%), Positives = 76/170 (44%), Gaps = 16/170 (9%)
Query: 385 VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGS 444
V+ SSD + + S DG + +WD+ + RFV + LS+A S + + + GS
Sbjct: 66 VSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGH-TKDVLSVAFSSDNRQIVSGS 124
Query: 445 NCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTEILAIASEKMKEAVRLVHL 504
+ ++N + T + V+ + F+P + I S + V++ +L
Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHS-----EWVSCVRFSPNSSNPIIVSCGWDKLVKVWNL 179
Query: 505 PSCTVFSNFPVIKNKNISH---VHTMDFSPRSGYFALGNEKGKALMYRLH 551
+C +K +I H ++T+ SP A G + G+A+++ L+
Sbjct: 180 ANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLN 222
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 42.7 bits (99), Expect = 9e-04
Identities = 40/197 (20%), Positives = 83/197 (42%), Gaps = 7/197 (3%)
Query: 258 QFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHS 317
+FHP + AG D + L+ V G + ++ + + ++ +G + + ST
Sbjct: 73 KFHPNGSTLASAGFDRLILLWNVYGDCD-NYATLKGHSGAVMELHYNTDGSMLFSAST-D 130
Query: 318 KVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIG 377
K + V+D G+ V +++G + + + G + L ++ K I
Sbjct: 131 KTVAVWDSETGE--RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQ 188
Query: 378 SMKINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEG-SLYGLSIATSRN 436
+ + +V A TF+ S ++ + D ++ VWD+ K S+ GLS+ S
Sbjct: 189 TFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSL--SSE 246
Query: 437 GQYVACGSNCGVVNIYN 453
G Y+ + V +++
Sbjct: 247 GSYLLSNAMDNTVRVWD 263
Score = 42.7 bits (99), Expect = 9e-04
Identities = 38/165 (23%), Positives = 74/165 (44%), Gaps = 16/165 (9%)
Query: 262 GAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKVLY 321
G Q+V D V L+ + K IQ+ + + + F+ +++++ + +
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKA--AIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIK- 218
Query: 322 VYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMK--------TK 373
V+D+ KL + +RG + + +S +GS+LL N + + + ++ K
Sbjct: 219 VWDLRQNKL--TYTMRGHADSVT-GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK 275
Query: 374 ELIGSM-KINGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCL 417
G++ + ++S D K+ A S D VYVWD SR+ L
Sbjct: 276 IFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
Score = 33.5 bits (75), Expect = 0.53
Identities = 24/105 (22%), Positives = 43/105 (40%), Gaps = 7/105 (6%)
Query: 382 NGRVAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVA 441
+G V +++D ++++S D V VWD + + + R S R Q V
Sbjct: 109 SGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
Query: 442 CGSNCGVVNIYNQDSCLQETNPKPIKAIMNLVTGVTSLTFNPTTE 486
GS+ G V ++ + K V ++TFN T++
Sbjct: 169 TGSDDGTVKLW-------DIRKKAAIQTFQNTYQVLAVTFNDTSD 206
>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
sapiens]
Length = 769
Score = 42.7 bits (99), Expect = 9e-04
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 29/207 (14%)
Query: 305 ANGEEVLATSTHSKVLYVYD-----------MLAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
++GE V A + + +VY G P+ Q+ L ++ +RS ++ PD
Sbjct: 481 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 540
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 541 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 600
Query: 410 DVNSRKCLNRFVDEGSLYGLS-IATSRNGQYVACGSNCGVVNIYN--QDSCLQETNPKPI 466
D++++ + +F +G G S I S +G + G V ++ + LQ+
Sbjct: 601 DLHNQTLVRQF--QGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ------ 652
Query: 467 KAIMNLVTGVTSLTFNPTTEILAIASE 493
+ + + SL + PT E LA+ E
Sbjct: 653 ---HDFTSQIFSLGYCPTGEWLAVGME 676
>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
sapiens]
Length = 760
Score = 42.7 bits (99), Expect = 9e-04
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 29/207 (14%)
Query: 305 ANGEEVLATSTHSKVLYVYD-----------MLAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
++GE V A + + +VY G P+ Q+ L ++ +RS ++ PD
Sbjct: 472 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 531
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 532 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 591
Query: 410 DVNSRKCLNRFVDEGSLYGLS-IATSRNGQYVACGSNCGVVNIYN--QDSCLQETNPKPI 466
D++++ + +F +G G S I S +G + G V ++ + LQ+
Sbjct: 592 DLHNQTLVRQF--QGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ------ 643
Query: 467 KAIMNLVTGVTSLTFNPTTEILAIASE 493
+ + + SL + PT E LA+ E
Sbjct: 644 ---HDFTSQIFSLGYCPTGEWLAVGME 667
>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
sapiens]
Length = 772
Score = 42.7 bits (99), Expect = 9e-04
Identities = 50/207 (24%), Positives = 90/207 (43%), Gaps = 29/207 (14%)
Query: 305 ANGEEVLATSTHSKVLYVYD-----------MLAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
++GE V A + + +VY G P+ Q+ L ++ +RS ++ PD
Sbjct: 484 SHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPD 543
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 544 GRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVW 603
Query: 410 DVNSRKCLNRFVDEGSLYGLS-IATSRNGQYVACGSNCGVVNIYN--QDSCLQETNPKPI 466
D++++ + +F +G G S I S +G + G V ++ + LQ+
Sbjct: 604 DLHNQTLVRQF--QGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQ------ 655
Query: 467 KAIMNLVTGVTSLTFNPTTEILAIASE 493
+ + + SL + PT E LA+ E
Sbjct: 656 ---HDFTSQIFSLGYCPTGEWLAVGME 679
>gi|223005859 WD repeat domain 67 isoform 1 [Homo sapiens]
Length = 1066
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/144 (27%), Positives = 69/144 (47%), Gaps = 17/144 (11%)
Query: 343 IVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAA--------STFSSDS 394
+ + F V+ DG L G + +LHL ++ ++L +++ +V A +F + S
Sbjct: 216 LYKVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAIRHLEFLPDSFDAGS 275
Query: 395 KKVYAS-SGDGEVYVWDVNSRKCLNRF--VDEGSLYGLSIATSRNGQYVACGSNCGVVNI 451
+V S DG + ++ + K L +DEG S A S +G+Y+A G +NI
Sbjct: 276 NQVLGVLSQDGIMRFINMQTCKLLFEIGSLDEGIS---SSAISPHGRYIASIMENGSLNI 332
Query: 452 YNQDSCLQETNPKP---IKAIMNL 472
Y+ + QE N P +K I +L
Sbjct: 333 YSVQALTQEINKPPPPLVKVIEDL 356
>gi|223005857 WD repeat domain 67 isoform 2 [Homo sapiens]
Length = 970
Score = 42.4 bits (98), Expect = 0.001
Identities = 40/144 (27%), Positives = 69/144 (47%), Gaps = 17/144 (11%)
Query: 343 IVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVAA--------STFSSDS 394
+ + F V+ DG L G + +LHL ++ ++L +++ +V A +F + S
Sbjct: 216 LYKVFAVTRDGRILAAGGKSNHLHLWCLEARQLFRIIQMPTKVRAIRHLEFLPDSFDAGS 275
Query: 395 KKVYAS-SGDGEVYVWDVNSRKCLNRF--VDEGSLYGLSIATSRNGQYVACGSNCGVVNI 451
+V S DG + ++ + K L +DEG S A S +G+Y+A G +NI
Sbjct: 276 NQVLGVLSQDGIMRFINMQTCKLLFEIGSLDEGIS---SSAISPHGRYIASIMENGSLNI 332
Query: 452 YNQDSCLQETNPKP---IKAIMNL 472
Y+ + QE N P +K I +L
Sbjct: 333 YSVQALTQEINKPPPPLVKVIEDL 356
>gi|53759148 retinoblastoma binding protein 5 [Homo sapiens]
Length = 538
Score = 42.0 bits (97), Expect = 0.001
Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 18/149 (12%)
Query: 207 DDESEEDEDDLLQRTGNFISTSTSLPRGILKMKNCQHANAE------RPTVARISSVQFH 260
DD+S+ + R G +I T + + ++ + Q A I S++F
Sbjct: 148 DDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFA 207
Query: 261 PGAQIVMVAGLDNAVSLFQV--------DGKTNP--KIQSIYLERFPIFKACFSANGEEV 310
++ D + ++ DG+ P K+Q + + R P K CFS +GE +
Sbjct: 208 RKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDL-VNRTPWKKCCFSGDGEYI 266
Query: 311 LATSTHSKVLYVYDMLAGKLIPV-HQVRG 338
+A S LY+++ G L+ + H RG
Sbjct: 267 VAGSARQHALYIWEKSIGNLVKILHGTRG 295
>gi|38327642 WD repeat domain 55 [Homo sapiens]
Length = 383
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/218 (24%), Positives = 97/218 (44%), Gaps = 34/218 (15%)
Query: 252 ARISSVQFHPGAQIVMVAGLDNAVSLFQV---DGKTNPKIQSIYLERFPIFKAC----FS 304
A S + FHP ++ +D V +F +G+T S + KAC FS
Sbjct: 39 APASGLAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHH-----LKACRAVAFS 93
Query: 305 ANGEEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLI--NGIA 362
+G++++ S K ++V D+ G+L E+ V +P S LL+ N +A
Sbjct: 94 EDGQKLITVSK-DKAIHVLDVEQGQL----------ERRVSKAHGAPINSLLLVDENVLA 142
Query: 363 -----GYLHLLAMKTKELIGSMKINGRVAASTFSSDSKKVY-ASSGDGEVYVWDVNSRKC 416
G + L + + + M+ + A +KK+ +SGDG + ++++ R+
Sbjct: 143 TGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMALDPAKKLLLTASGDGCLGIFNIKRRRF 202
Query: 417 -LNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYN 453
L G L S+ + G+ VACGS+ G + ++N
Sbjct: 203 ELLSEPQSGDL--TSVTLMKWGKKVACGSSEGTIYLFN 238
>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
sapiens]
Length = 421
Score = 41.2 bits (95), Expect = 0.003
Identities = 43/162 (26%), Positives = 75/162 (46%), Gaps = 12/162 (7%)
Query: 264 QIVMVAGLDNA-VSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLATSTHSKVLYV 322
Q+++ GL+N + ++ V T + ++ + F+ +G +L +++ K L V
Sbjct: 140 QLLLATGLNNGRIKIWDV--YTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRV 197
Query: 323 YDMLA-GKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKI 381
+D+ G ++ V +RG + V S SPD S L G + + L M +I K+
Sbjct: 198 WDLKDDGNMMKV--LRG-HQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMI--RKL 252
Query: 382 NGR---VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRF 420
G V A FS D + +S D VY+WD ++ L F
Sbjct: 253 EGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILMEF 294
Score = 38.9 bits (89), Expect = 0.013
Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 38/178 (21%)
Query: 254 ISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLAT 313
+ S F P + ++ G AV L+ +D T I+ + + FS +G +LAT
Sbjct: 217 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYT--MIRKLEGHHHDVVACDFSPDGA-LLAT 273
Query: 314 STHSKVLYVYD-------MLAGKLIPVHQ---VRGLKEKIVRSFEVSPDGSFLLINGIAG 363
+++ +Y++D M G L P G ++ VRS S DG
Sbjct: 274 ASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG---------- 323
Query: 364 YLHLLAMKTKELIGSMKI------------NGRVAASTFSSDSKKVYASSGDGEVYVW 409
LH+ ++ +++ +I NG A FS+D + A + DG VY W
Sbjct: 324 -LHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 378
>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
sapiens]
Length = 621
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 15/131 (11%)
Query: 305 ANGEEVLATSTHSKVLYVYDM-----------LAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
A+GE V A + +VY G PV Q+ L ++ +RS ++ PD
Sbjct: 333 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 392
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 393 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 452
Query: 410 DVNSRKCLNRF 420
D+ ++ + +F
Sbjct: 453 DLQNQTMVRQF 463
>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
sapiens]
Length = 706
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 15/131 (11%)
Query: 305 ANGEEVLATSTHSKVLYVYDM-----------LAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
A+GE V A + +VY G PV Q+ L ++ +RS ++ PD
Sbjct: 469 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 528
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 529 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 588
Query: 410 DVNSRKCLNRF 420
D+ ++ + +F
Sbjct: 589 DLQNQTMVRQF 599
>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
sapiens]
Length = 743
Score = 41.2 bits (95), Expect = 0.003
Identities = 34/131 (25%), Positives = 58/131 (44%), Gaps = 15/131 (11%)
Query: 305 ANGEEVLATSTHSKVLYVYDM-----------LAGKLIPVHQVRGL-KEKIVRSFEVSPD 352
A+GE V A + +VY G PV Q+ L ++ +RS ++ PD
Sbjct: 455 AHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD 514
Query: 353 GSFLLINGIAGYLHL--LAMKTKELIGSMKINGRVA-ASTFSSDSKKVYASSGDGEVYVW 409
G L++ G A L + LA T + + + A S D+K ++ DG + VW
Sbjct: 515 GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVW 574
Query: 410 DVNSRKCLNRF 420
D+ ++ + +F
Sbjct: 575 DLQNQTMVRQF 585
>gi|20143912 WD repeat and SOCS box-containing 1 isoform 2 [Homo
sapiens]
Length = 275
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 9/122 (7%)
Query: 303 FSANGEEVLATSTHSKVLYVYDMLA-GKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGI 361
F+ +G +L +++ K L V+D+ G ++ V +RG + V S SPD S L G
Sbjct: 32 FAPDGSLILVSASRDKTLRVWDLKDDGNMMKV--LRG-HQNWVYSCAFSPDSSMLCSVGA 88
Query: 362 AGYLHLLAMKTKELIGSMKINGR---VAASTFSSDSKKVYASSGDGEVYVWDVNSRKCLN 418
+ + L M +I K+ G V A FS D + +S D VY+WD ++ L
Sbjct: 89 SKAVFLWNMDKYTMI--RKLEGHHHDVVACDFSPDGALLATASYDTRVYIWDPHNGDILM 146
Query: 419 RF 420
F
Sbjct: 147 EF 148
Score = 38.9 bits (89), Expect = 0.013
Identities = 44/178 (24%), Positives = 73/178 (41%), Gaps = 38/178 (21%)
Query: 254 ISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANGEEVLAT 313
+ S F P + ++ G AV L+ +D T I+ + + FS +G +LAT
Sbjct: 71 VYSCAFSPDSSMLCSVGASKAVFLWNMDKYT--MIRKLEGHHHDVVACDFSPDGA-LLAT 127
Query: 314 STHSKVLYVYD-------MLAGKLIPVHQ---VRGLKEKIVRSFEVSPDGSFLLINGIAG 363
+++ +Y++D M G L P G ++ VRS S DG
Sbjct: 128 ASYDTRVYIWDPHNGDILMEFGHLFPPPTPIFAGGANDRWVRSVSFSHDG---------- 177
Query: 364 YLHLLAMKTKELIGSMKI------------NGRVAASTFSSDSKKVYASSGDGEVYVW 409
LH+ ++ +++ +I NG A FS+D + A + DG VY W
Sbjct: 178 -LHVASLADDKMVRFWRIDEDYPVQVAPLSNGLCCA--FSTDGSVLAAGTHDGSVYFW 232
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 11/167 (6%)
Query: 248 RPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANG 307
R ++++VQF+ A +++ +D+++ + + +Q++ R + + +
Sbjct: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGV--SSVKVSD 163
Query: 308 EEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHL 367
E+LA S +V YD+ G+L + + S DG L++ + L L
Sbjct: 164 HEILAGSVDGRVRR-YDLRMGQLFSDYV-----GSPITCTCFSRDGQCTLVSSLDSTLRL 217
Query: 368 LAMKTKELIGSMKINGRVAAS---TFSSDSKKVYASSGDGEVYVWDV 411
L T EL+G K + S V + S DG+V+ WD+
Sbjct: 218 LDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDL 264
Score = 29.3 bits (64), Expect = 9.9
Identities = 32/147 (21%), Positives = 62/147 (42%), Gaps = 7/147 (4%)
Query: 344 VRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKING-RVAASTFSSDSKKVYASSG 402
VR+ + DG++ L G L L L+ + +G V + S D+ + + G
Sbjct: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
Query: 403 DGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETN 462
D V +WDV S + + +F ++ + + GS + ++ +
Sbjct: 88 DKAVVLWDVASGQVVRKFRGHAGKVN-TVQFNEEATVILSGSIDSSIRCWD----CRSRR 142
Query: 463 PKPIKAIMNLVTGVTSLTFNPTTEILA 489
P+P++ + GV+S+ + EILA
Sbjct: 143 PEPVQTLDEARDGVSSVKVS-DHEILA 168
>gi|30520335 WD repeat domain 49 [Homo sapiens]
Length = 697
Score = 40.8 bits (94), Expect = 0.003
Identities = 32/143 (22%), Positives = 57/143 (39%), Gaps = 21/143 (14%)
Query: 327 AGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKINGRVA 386
AG+ P H + VR+FE+ +G N + L A K + G +
Sbjct: 342 AGRSQPSHPMADHSTTGVRNFEIDTEGK----NAVMRLCFLKARKNTAVTGGANL----- 392
Query: 387 ASTFSSDSKKVYASSGDGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNC 446
+ G G V WD+ ++ L F+ + + ++T + +Y+ G
Sbjct: 393 -----------VSCGGSGYVRFWDIYKKQLLAEFLAHSGVGSIIMSTDKMNRYLTTGDLD 441
Query: 447 GVVNIYN-QDSCLQETNPKPIKA 468
G + I+N ++ CL + K KA
Sbjct: 442 GWLKIWNIEEYCLNSSKNKITKA 464
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/167 (22%), Positives = 72/167 (43%), Gaps = 11/167 (6%)
Query: 248 RPTVARISSVQFHPGAQIVMVAGLDNAVSLFQVDGKTNPKIQSIYLERFPIFKACFSANG 307
R ++++VQF+ A +++ +D+++ + + +Q++ R + + +
Sbjct: 106 RGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGV--SSVKVSD 163
Query: 308 EEVLATSTHSKVLYVYDMLAGKLIPVHQVRGLKEKIVRSFEVSPDGSFLLINGIAGYLHL 367
E+LA S +V YD+ G+L + + S DG L++ + L L
Sbjct: 164 HEILAGSVDGRVRR-YDLRMGQLFSDYV-----GSPITCTCFSRDGQCTLVSSLDSTLRL 217
Query: 368 LAMKTKELIGSMKINGRVAAS---TFSSDSKKVYASSGDGEVYVWDV 411
L T EL+G K + S V + S DG+V+ WD+
Sbjct: 218 LDKDTGELLGEYKGHKNQEYKLDCCLSERDTHVVSCSEDGKVFFWDL 264
Score = 29.3 bits (64), Expect = 9.9
Identities = 32/147 (21%), Positives = 62/147 (42%), Gaps = 7/147 (4%)
Query: 344 VRSFEVSPDGSFLLINGIAGYLHLLAMKTKELIGSMKING-RVAASTFSSDSKKVYASSG 402
VR+ + DG++ L G L L L+ + +G V + S D+ + + G
Sbjct: 28 VRAVRFNVDGNYCLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGG 87
Query: 403 DGEVYVWDVNSRKCLNRFVDEGSLYGLSIATSRNGQYVACGSNCGVVNIYNQDSCLQETN 462
D V +WDV S + + +F ++ + + GS + ++ +
Sbjct: 88 DKAVVLWDVASGQVVRKFRGHAGKVN-TVQFNEEATVILSGSIDSSIRCWD----CRSRR 142
Query: 463 PKPIKAIMNLVTGVTSLTFNPTTEILA 489
P+P++ + GV+S+ + EILA
Sbjct: 143 PEPVQTLDEARDGVSSVKVS-DHEILA 168
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,919,221
Number of Sequences: 37866
Number of extensions: 1162457
Number of successful extensions: 12622
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 133
Number of HSP's successfully gapped in prelim test: 490
Number of HSP's that attempted gapping in prelim test: 11045
Number of HSP's gapped (non-prelim): 1828
length of query: 556
length of database: 18,247,518
effective HSP length: 107
effective length of query: 449
effective length of database: 14,195,856
effective search space: 6373939344
effective search space used: 6373939344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.