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Search of human proteins with 117956371
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
(663 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 1346 0.0
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 1333 0.0
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 1316 0.0
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 1305 0.0
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 1293 0.0
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 1276 0.0
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 1273 0.0
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 977 0.0
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 809 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 568 e-162
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 566 e-161
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 469 e-132
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 461 e-129
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 348 7e-96
gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens] 176 6e-44
gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens] 176 6e-44
gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens] 176 6e-44
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 143 6e-34
gi|187608516 centaurin, beta 2 [Homo sapiens] 130 3e-30
gi|7661880 centaurin beta1 [Homo sapiens] 126 6e-29
gi|46094081 development and differentiation enhancing factor 1 [... 126 7e-29
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 121 2e-27
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 121 2e-27
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 121 2e-27
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 121 2e-27
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 121 2e-27
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 121 2e-27
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 119 9e-27
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 119 9e-27
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 115 1e-25
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 1346 bits (3484), Expect = 0.0
Identities = 663/663 (100%), Positives = 663/663 (100%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
Sbjct: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS 360
KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS 360
Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
Query: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
Query: 481 GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
Sbjct: 481 GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD 600
ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD 600
Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
Query: 661 ECV 663
ECV
Sbjct: 661 ECV 663
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 1333 bits (3451), Expect = 0.0
Identities = 658/663 (99%), Positives = 661/663 (99%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS
Sbjct: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS 360
KNIHKKEIDLQTSTIKVPGKWPSLATSACTPIS+SKSNGLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISS 360
Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
Query: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
ASLQSCESSKSKSQLTSQS+AMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
Query: 481 GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
GIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK
Sbjct: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD 600
ERWIRSKYEEKLFLAPLPCTELSLGQQLL ATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600
Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
Query: 661 ECV 663
+CV
Sbjct: 661 KCV 663
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 1316 bits (3406), Expect = 0.0
Identities = 651/663 (98%), Positives = 654/663 (98%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYS 120
DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTV FSQQYS
Sbjct: 61 DLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVHFSQQYS 120
Query: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMK 180
LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHI K
Sbjct: 121 LCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITK 180
Query: 181 KRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD
Sbjct: 181 NRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPD 240
Query: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM
Sbjct: 241 KERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYM 300
Query: 301 KNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSNGLSKDMDTGLGDSICFSPSISS 360
K IHKKEIDLQTSTIKVPGKWPSLAT ACTPISSSKS+GLSKDMDTGLGDSICFSPSISS
Sbjct: 301 KYIHKKEIDLQTSTIKVPGKWPSLATLACTPISSSKSDGLSKDMDTGLGDSICFSPSISS 360
Query: 361 TTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
TT PKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL
Sbjct: 361 TTIPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQIL 420
Query: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS
Sbjct: 421 ASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECS 480
Query: 481 GIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEK 540
GIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQG+TKP+EKSTREEK
Sbjct: 481 GIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGRTKPTEKSTREEK 540
Query: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGD 600
ERWIRSKYEEKLFLAPLPCTELSLGQQLL ATADEDLQTAILLLAHGSREEVNETCGEGD
Sbjct: 541 ERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGD 600
Query: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD
Sbjct: 601 GCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPD 660
Query: 661 ECV 663
ECV
Sbjct: 661 ECV 663
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 1305 bits (3376), Expect = 0.0
Identities = 652/686 (95%), Positives = 654/686 (95%), Gaps = 23/686 (3%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESE YEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESETYEAGARDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
DLHMHHVRDREMPEALEFN PSANPEASTIFQRNSQTD
Sbjct: 61 DLHMHHVRDREMPEALEFNLSANPESSTIFQRNSQTEALEFNPSANPEASTIFQRNSQTD 120
Query: 98 VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
VVEIRRSNCTNHVS VRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSAVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
DR+LSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRTLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337
KKKYVTLCSNG+LTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS
Sbjct: 301 KKKYVTLCSNGMLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 360
Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457
WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
Query: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
DCETQNPKWASLNLGVLMCIECSGIH SLG LSRVRSLELDDWPVELRKVMSSI NDLA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLA 540
Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577
NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLL ATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDL 600
Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
QTAILLLAHGS EEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
Query: 638 LTYARQASSQECINVLLQYGCPDECV 663
LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 1293 bits (3347), Expect = 0.0
Identities = 647/686 (94%), Positives = 650/686 (94%), Gaps = 23/686 (3%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTC VHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEF-----------------------NPSANPEASTIFQRNSQTD 97
DLHMHH+RD+EMPEALEF NPSANPEASTIFQRNSQTD
Sbjct: 61 DLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTD 120
Query: 98 VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTA QHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDA 180
Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
DRSLSIPDEQLHSFAVSTVHI K RNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 240
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
TPVCKRSMRWSNLFTSEKGS PDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337
KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457
WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
Query: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
D ETQNPKWASLNLGVLMCIECSGIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA
Sbjct: 481 DYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 540
Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577
NSIWEGSSQGQTKPS KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ LL ATADEDL
Sbjct: 541 NSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDL 600
Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 660
Query: 638 LTYARQASSQECINVLLQYGCPDECV 663
LTYARQASSQECINVLLQYGCPDECV
Sbjct: 661 LTYARQASSQECINVLLQYGCPDECV 686
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 1276 bits (3301), Expect = 0.0
Identities = 642/686 (93%), Positives = 645/686 (94%), Gaps = 25/686 (3%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
DLHMH VRDREMPEALEFN SANPEASTIFQRNSQTD
Sbjct: 61 DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120
Query: 98 VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337
KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457
WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
Query: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
DCETQNPKWASLNLGVLMCIECSGIH S GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540
Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577
NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLL AT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600
Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658
Query: 638 LTYARQASSQECINVLLQYGCPDECV 663
LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 1273 bits (3294), Expect = 0.0
Identities = 641/686 (93%), Positives = 644/686 (93%), Gaps = 25/686 (3%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGA DRMAGAPMAAAVQPAEVTVEVGE
Sbjct: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAEDRMAGAPMAAAVQPAEVTVEVGE 60
Query: 61 DLHMHHVRDREMPEALEFN-----------------------PSANPEASTIFQRNSQTD 97
DLHMH VRDREMPEALEFN SANPEASTIFQRNSQTD
Sbjct: 61 DLHMHQVRDREMPEALEFNLSANPEASTIFQRNSQTDALEFNSSANPEASTIFQRNSQTD 120
Query: 98 VVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 157
VVEIRRSNCTNHVST RFSQQYS CSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA
Sbjct: 121 VVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDA 180
Query: 158 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIP TPSTSQEDPQFSVPPTANTP
Sbjct: 181 DRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPPTPSTSQEDPQFSVPPTANTP 240
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 277
TPVCK SMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW
Sbjct: 241 TPVCKLSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTW 300
Query: 278 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKS 337
KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVPGKWPSLATSAC PISSSKS
Sbjct: 301 KKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKS 360
Query: 338 NGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 397
NGLSKDMDTGLGDSICFSP ISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT
Sbjct: 361 NGLSKDMDTGLGDSICFSPGISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQT 420
Query: 398 WHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCV 457
WHFEATTYEERDAWVQAIQSQILASLQSC+SSKSKSQLTSQSEAMALQSIQNMRGNAHCV
Sbjct: 421 WHFEATTYEERDAWVQAIQSQILASLQSCKSSKSKSQLTSQSEAMALQSIQNMRGNAHCV 480
Query: 458 DCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLA 517
DCETQNPKWASLNLGVLMCIECSGIH S GTRLSRVRSLELDDWPVELRKVMSSIGN+LA
Sbjct: 481 DCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSIGNELA 540
Query: 518 NSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDL 577
NSIWEGSSQGQTKPS KSTREEKE WIRSKYEEKLFLAPLPCTELSLGQQLL AT DEDL
Sbjct: 541 NSIWEGSSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLRATTDEDL 600
Query: 578 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTA 637
QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL QLL GVDVMARDAHGNTA
Sbjct: 601 QTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLEQLL--XGVDVMARDAHGNTA 658
Query: 638 LTYARQASSQECINVLLQYGCPDECV 663
LTYARQASSQECINVLLQYGCPDECV
Sbjct: 659 LTYARQASSQECINVLLQYGCPDECV 684
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 977 bits (2525), Expect = 0.0
Identities = 494/550 (89%), Positives = 505/550 (91%), Gaps = 25/550 (4%)
Query: 139 MTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPST 198
MTIISVTLEI HHIT+RDADRSL+I DEQL+SFA STVHI KKRNGGGSLNNYSSSIP T
Sbjct: 1 MTIISVTLEIHHHITERDADRSLTILDEQLYSFAFSTVHITKKRNGGGSLNNYSSSIPLT 60
Query: 199 PSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRA 258
PSTSQED FSVPPTANTPTP+CK+SM WSNLFTSEKGSDPDK RKA E+HADTIGSGRA
Sbjct: 61 PSTSQEDLYFSVPPTANTPTPICKQSMGWSNLFTSEKGSDPDKGRKALESHADTIGSGRA 120
Query: 259 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVP 318
IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDL+TSTIKVP
Sbjct: 121 IPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVP 180
Query: 319 GKWPSLATSACTPISSSKSNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPP 369
GKWPSLATSAC PISSSKSNGLSKDM D GLGDSICFSPSISSTTSPKLN P
Sbjct: 181 GKWPSLATSACAPISSSKSNGLSKDMEALHMSANSDIGLGDSICFSPSISSTTSPKLNLP 240
Query: 370 PSPHANKKKHLKKKSTNN----------------FMIVSATGQTWHFEATTYEERDAWVQ 413
PSPHANKKKHLKKKSTNN FMIVS TGQT HF+ATTYEERDAWVQ
Sbjct: 241 PSPHANKKKHLKKKSTNNLKDDGLSSTAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQ 300
Query: 414 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGV 473
AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGN+HCVDCETQNPKWASLNLGV
Sbjct: 301 AIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGV 360
Query: 474 LMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSE 533
LMCIECSGIH SLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPS
Sbjct: 361 LMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSI 420
Query: 534 KSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVN 593
+STREEKERWIRSKYE KLFLAPLPCTELSLGQ LL ATADEDL+TAILLLAHGSREEVN
Sbjct: 421 ESTREEKERWIRSKYEHKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVN 480
Query: 594 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 653
ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL
Sbjct: 481 ETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVL 540
Query: 654 LQYGCPDECV 663
LQYGCPDECV
Sbjct: 541 LQYGCPDECV 550
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 809 bits (2090), Expect = 0.0
Identities = 412/532 (77%), Positives = 452/532 (84%), Gaps = 32/532 (6%)
Query: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
S+P+ HS VS VHI + NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
Query: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 336
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSAC PISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
Query: 337 SNGLSKDM---------DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNN 387
+NGLSKDM DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+N
Sbjct: 425 TNGLSKDMSSLHISPNSDTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSN 484
Query: 388 F------------------MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESS 429
F +IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESS
Sbjct: 485 FKADGLSGTAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESS 544
Query: 430 KSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTR 489
K+KS+LTSQSEAMALQSI+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIH +LGT
Sbjct: 545 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTH 604
Query: 490 LSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYE 549
LSRVRSL+LDDWPVEL KVMSSIGN+LANS+WE SSQG+TKPS STREEKERWIR+KYE
Sbjct: 605 LSRVRSLDLDDWPVELIKVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYE 664
Query: 550 EKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLAC 609
+KLFLAPLPCTELSLGQ LL ATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLAC
Sbjct: 665 QKLFLAPLPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLAC 724
Query: 610 RKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
RKGNVVLAQLLIWYGVDV ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 725 RKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 776
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 568 bits (1465), Expect = e-162
Identities = 304/582 (52%), Positives = 387/582 (66%), Gaps = 82/582 (14%)
Query: 162 SIPDEQLHSF----AVSTVHIMKKRNGGGS-LNNYSSSIPSTPSTSQEDPQFSVPPTANT 216
S+P+ HS ++ VHI + NGGGS ++YSSS+PSTPS SQ + + ++T
Sbjct: 301 SLPNSPSHSAVSAASIPAVHINQATNGGGSAFSDYSSSVPSTPSISQRELRIETIAASST 360
Query: 217 PTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-K 275
PTP+ K+S R SN+FTS KG+D D+E+KA E D+IGSGRAIPIKQG+LLKRSGK L K
Sbjct: 361 PTPIRKQSKRRSNIFTSRKGADLDREKKAAECKVDSIGSGRAIPIKQGILLKRSGKSLNK 420
Query: 276 TWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTP---- 331
WKKKYVTLC NG+LTY+ SL DYM+NIH KEIDL +T+KVPGK AT A P
Sbjct: 421 EWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPATAPGTSP 480
Query: 332 ----ISSSKSN--------------GLSKDMDTGLGDSICFSP----------SISS--- 360
+S +SN S + L S P S+SS
Sbjct: 481 RANGLSVERSNTQLGGGTGAPHSASSASLHSERPLSSSAWAGPRPEGLHQRSCSVSSADQ 540
Query: 361 -----------------------TTSPKLNPPPSPHANKKKHLKKKSTNN---------- 387
++SPKL+PPPSPH+N+KKH +KKST
Sbjct: 541 WSEATTSLPPGMQHPASGPAEVLSSSPKLDPPPSPHSNRKKHRRKKSTGTPRPDGPSSAT 600
Query: 388 --------FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQS 439
F++VS TGQTWHFEA+T EER+ WVQ++Q+QILASLQ C S+K K++L +Q+
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQN 660
Query: 440 EAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELD 499
A+A+Q+++ +RGN+ C+DC+ NP WASLNLG LMCIECSGIH LG LSRVRSL+LD
Sbjct: 661 AALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLD 720
Query: 500 DWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPC 559
DWP EL VM+++GN LANS+WEG+ G +KP + REEKERWIR+KYE+KLFLAPLP
Sbjct: 721 DWPPELLAVMTAMGNALANSVWEGALGGYSKPGPDACREEKERWIRAKYEQKLFLAPLPS 780
Query: 560 TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQL 619
+++ LGQQLL A ++DL+ ++LLAHGS+EEVNET G+GDG TALHL+ NVV QL
Sbjct: 781 SDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQL 840
Query: 620 LIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
LIWYGVDV +RDA G T L YAR+A SQEC ++L+Q+GCP E
Sbjct: 841 LIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGE 882
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 566 bits (1458), Expect = e-161
Identities = 280/335 (83%), Positives = 301/335 (89%), Gaps = 18/335 (5%)
Query: 345 DTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNF---------------- 388
DTGLGDS+C SPSISSTTSPKL+PPPSPHAN+KKH +KKST+NF
Sbjct: 495 DTGLGDSVCSSPSISSTTSPKLDPPPSPHANRKKHRRKKSTSNFKADGLSGTAEEQEENF 554
Query: 389 --MIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQS 446
+IVS TGQTWHFEATTYEERDAWVQAI+SQILASLQSCESSK+KS+LTSQSEAMALQS
Sbjct: 555 EFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSCESSKNKSRLTSQSEAMALQS 614
Query: 447 IQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELR 506
I+NMRGN+HCVDCETQNP WASLNLG LMCIECSGIH +LGT LSRVRSL+LDDWPVEL
Sbjct: 615 IRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELI 674
Query: 507 KVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQ 566
KVMSSIGN+LANS+WE SSQG+TKPS STREEKERWIR+KYE+KLFLAPLPCTELSLGQ
Sbjct: 675 KVMSSIGNELANSVWEESSQGRTKPSVDSTREEKERWIRAKYEQKLFLAPLPCTELSLGQ 734
Query: 567 QLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVD 626
LL ATADEDL+TAILLLAHGSR+EVNETCGEGDG TALHLACRKGNVVLAQLLIWYGVD
Sbjct: 735 HLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVLAQLLIWYGVD 794
Query: 627 VMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
V ARDAHGNTAL YARQASSQECI+VLLQYGCPDE
Sbjct: 795 VTARDAHGNTALAYARQASSQECIDVLLQYGCPDE 829
Score = 258 bits (659), Expect = 1e-68
Identities = 137/207 (66%), Positives = 159/207 (76%), Gaps = 10/207 (4%)
Query: 162 SIPDEQLHSFA----VSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTP 217
S+P+ HS VS VHI + NGGGSL++YSSS+PSTPSTSQ++ + VPPTANTP
Sbjct: 245 SLPNSPSHSSVCSAQVSAVHISQTSNGGGSLSDYSSSVPSTPSTSQKELRIDVPPTANTP 304
Query: 218 TPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KT 276
TPV K+S R SNLFTS KGSDPDKE+K E+ AD+IGSGRAIPIKQGMLLKRSGK L K
Sbjct: 305 TPVRKQSKRRSNLFTSRKGSDPDKEKKGLESRADSIGSGRAIPIKQGMLLKRSGKSLNKE 364
Query: 277 WKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSK 336
WKKKYVTLC NGVLTY+ SL DYM+N+H KEIDL +T+KVPGK P ATSAC PISS K
Sbjct: 365 WKKKYVTLCDNGVLTYHPSLHDYMQNVHGKEIDLLRTTVKVPGKRPPRATSACAPISSPK 424
Query: 337 SNGLSKDMDTGLGDSICFSPSISSTTS 363
+NGLSKDM S+ SP+ + TS
Sbjct: 425 TNGLSKDM-----SSLHISPNSGNVTS 446
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 469 bits (1207), Expect = e-132
Identities = 265/557 (47%), Positives = 346/557 (62%), Gaps = 63/557 (11%)
Query: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 245 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 302
Query: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 303 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 360
Query: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 338
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 361 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 418
Query: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
GL KDM T +G+ + SPS SS P
Sbjct: 419 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 478
Query: 365 ------KLNPPPSPHANKKKHLK--------------KKSTNNFMIVSATGQTWHFEATT 404
PPPSP K++ K ++ F+IVS+TGQTWHFEA +
Sbjct: 479 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEEENFEFLIVSSTGQTWHFEAAS 538
Query: 405 YEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNP 464
+EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+Q+I+N +GN+ CVDC NP
Sbjct: 539 FEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNP 598
Query: 465 KWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS 524
WASLNLG L+CIECSGIH +LGT LSRVRSL+LDDWP EL V+++IGND AN +WE
Sbjct: 599 TWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESD 658
Query: 525 SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLL 584
++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E LG+QL A +D+ T +LLL
Sbjct: 659 TRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLL 718
Query: 585 AHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQA 644
AH ++ + + + LHLA +VV+ QLL+WYG DV ARDA G TAL YARQA
Sbjct: 719 AHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQA 778
Query: 645 SSQECINVLLQYGCPDE 661
SQ C ++LLQ+GCP E
Sbjct: 779 GSQLCADILLQHGCPGE 795
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 461 bits (1186), Expect = e-129
Identities = 265/577 (45%), Positives = 346/577 (59%), Gaps = 83/577 (14%)
Query: 162 SIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTP-- 219
S+P HS A + V + + GG ++YSSS+PS+P+ + + A TP
Sbjct: 581 SLPSSPSHSAASTPV--AGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGS 638
Query: 220 VCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWL-KTWK 278
+ + + R ++LF + +GSD E+++ ++ +T GSGRAIPIKQ LLKRSG L K WK
Sbjct: 639 LHRAAKRRTSLFANRRGSD--SEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWK 696
Query: 279 KKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISSSKSN 338
KKYVTL SNG L Y+ S+ DY+ + H KE+DL +T+KVPGK P A SA P S+ N
Sbjct: 697 KKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGP--SASIN 754
Query: 339 GLSKDMDT-GLGDSI-------CFSPSISSTTSP-------------------------- 364
GL KDM T +G+ + SPS SS P
Sbjct: 755 GLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPS 814
Query: 365 ------KLNPPPSPHANKKKHLKKKSTNN------------------------------- 387
PPPSP K++ K + +
Sbjct: 815 GDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEE 874
Query: 388 ---FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMAL 444
F+IVS+TGQTWHFEA ++EERDAWVQAI+SQILASLQ CESSK K + SQSEA+A+
Sbjct: 875 NFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAI 934
Query: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVE 504
Q+I+N +GN+ CVDC NP WASLNLG L+CIECSGIH +LGT LSRVRSL+LDDWP E
Sbjct: 935 QAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRE 994
Query: 505 LRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSL 564
L V+++IGND AN +WE ++G+ KPS S+REE+E WIR+KYE+ LFLAPL +E L
Sbjct: 995 LTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPL 1054
Query: 565 GQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 624
G+QL A +D+ T +LLLAH ++ + + + LHLA +VV+ QLL+WYG
Sbjct: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
Query: 625 VDVMARDAHGNTALTYARQASSQECINVLLQYGCPDE 661
DV ARDA G TAL YARQA SQ C ++LLQ+GCP E
Sbjct: 1115 ADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGE 1151
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 348 bits (894), Expect = 7e-96
Identities = 171/173 (98%), Positives = 172/173 (99%)
Query: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 550
SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEE 171
Query: 551 KLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 610
KLFLAPLPCT+LSLGQQLL ATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR
Sbjct: 172 KLFLAPLPCTDLSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACR 231
Query: 611 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 663
KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV
Sbjct: 232 KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV 284
Score = 39.7 bits (91), Expect = 0.009
Identities = 18/18 (100%), Positives = 18/18 (100%)
Query: 155 RDADRSLSIPDEQLHSFA 172
RDADRSLSIPDEQLHSFA
Sbjct: 94 RDADRSLSIPDEQLHSFA 111
>gi|239755288 PREDICTED: cyclin Y-like 2 [Homo sapiens]
Length = 362
Score = 176 bits (446), Expect = 6e-44
Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTC V P S Q QG VC ESEIYEA AGD +AG P+AAAV+P EVT GE
Sbjct: 1 MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60
Query: 61 DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
LHMHH+ +REMPE LE NPS +P+ASTIF R SQTDV E ++ VST F+QQ
Sbjct: 61 GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119
Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
YS CSTIFLDDS A Q +LTMT+ S I + +RDA RSL I DEQLH V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176
>gi|239749780 PREDICTED: cyclin Y-like 2 [Homo sapiens]
Length = 362
Score = 176 bits (446), Expect = 6e-44
Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTC V P S Q QG VC ESEIYEA AGD +AG P+AAAV+P EVT GE
Sbjct: 1 MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60
Query: 61 DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
LHMHH+ +REMPE LE NPS +P+ASTIF R SQTDV E ++ VST F+QQ
Sbjct: 61 GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119
Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
YS CSTIFLDDS A Q +LTMT+ S I + +RDA RSL I DEQLH V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176
>gi|239744040 PREDICTED: cyclin Y-like 2 [Homo sapiens]
Length = 362
Score = 176 bits (446), Expect = 6e-44
Identities = 104/177 (58%), Positives = 118/177 (66%), Gaps = 5/177 (2%)
Query: 1 MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGE 60
MGNILTC V P S Q QG VC ESEIYEA AGD +AG P+AAAV+P EVT GE
Sbjct: 1 MGNILTCCVCPRASPGLHQHQGLVCHCESEIYEAAAGDLIAGVPVAAAVEPGEVTFVAGE 60
Query: 61 DLHMHHVRDREMPE--ALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQ 118
LHMHH+ +REMPE LE NPS +P+ASTIF R SQTDV E ++ VST F+QQ
Sbjct: 61 GLHMHHICEREMPEDIPLEPNPSDHPKASTIFLRKSQTDVQEKKKKQLCK-VSTEHFTQQ 119
Query: 119 YSLCSTIFLDDSTAIQHYLTMTIISV--TLEIPHHITQRDADRSLSIPDEQLHSFAV 173
YS CSTIFLDDS A Q +LTMT+ S I + +RDA RSL I DEQLH V
Sbjct: 120 YSSCSTIFLDDSIASQPHLTMTLKSXCDLGTILSYQAKRDAHRSLGIFDEQLHPLTV 176
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 143 bits (360), Expect = 6e-34
Identities = 80/192 (41%), Positives = 113/192 (58%), Gaps = 22/192 (11%)
Query: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQ----SCES-------SKSKSQLT 436
F ++S T ++ +A + + R AWVQA+Q+ I ++ + SC S S S S +
Sbjct: 332 FEVLSPT-KSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSID 390
Query: 437 SQSEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGT 488
S ++ LQ +Q++ GN+ C DC +P+WAS+NLGVL+CIECSGIH SLG
Sbjct: 391 SATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGV 450
Query: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQ--GQTKPSEKSTREEKERWIRS 546
S+VRSL LD W EL K+M +GN N I+E + G KP+ S+R++KE WI+
Sbjct: 451 HCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKD 510
Query: 547 KYEEKLFLAPLP 558
KY EK FL P
Sbjct: 511 KYVEKKFLRKAP 522
Score = 39.3 bits (90), Expect = 0.012
Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 2/71 (2%)
Query: 571 ATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMAR 630
A DL LAHG+ EVN E +G T L A G++++ + L+ G DV R
Sbjct: 675 AARARDLPALAAALAHGA--EVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732
Query: 631 DAHGNTALTYA 641
D+ G L +A
Sbjct: 733 DSRGRAPLHHA 743
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 130 bits (328), Expect = 3e-30
Identities = 75/186 (40%), Positives = 110/186 (59%), Gaps = 21/186 (11%)
Query: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 438
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
Query: 439 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRL 490
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIH SLG
Sbjct: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
Query: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 548
S+VRSL LD W EL K+M +GND+ N ++E + G KP + R+EKE +IR+KY
Sbjct: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507
Query: 549 EEKLFL 554
E+ F+
Sbjct: 508 VERKFV 513
Score = 35.4 bits (80), Expect = 0.17
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 557 LPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
L L+ G QL A+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
Query: 617 AQLLIWYGVDVMARDAHGNTALTYA 641
+ L+ G +V RD G L +A
Sbjct: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 126 bits (317), Expect = 6e-29
Identities = 73/194 (37%), Positives = 98/194 (50%), Gaps = 26/194 (13%)
Query: 391 VSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSK-------------SQLTS 437
V +T ++ +A + WV A+QS I ++ S S T
Sbjct: 331 VVSTSKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATL 390
Query: 438 QSEAMA-----------LQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSL 486
S MA + +Q++ GNA C DC P+WAS+NLGV +CI+CSGIH SL
Sbjct: 391 GSGGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSL 450
Query: 487 GTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT--KPSEKSTREEKERWI 544
G S+VRSL LD W EL K+M +GN + N I+E + KP +R+EKE WI
Sbjct: 451 GVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWI 510
Query: 545 RSKYEEKLFLAPLP 558
+KY EK FL LP
Sbjct: 511 HAKYVEKKFLTKLP 524
Score = 40.0 bits (92), Expect = 0.007
Identities = 27/86 (31%), Positives = 42/86 (48%), Gaps = 4/86 (4%)
Query: 568 LLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDV 627
L+ ATA L LL +G+ ++ G G LH A G+ LA L + G D+
Sbjct: 611 LIQATAANSLLACEFLLQNGANVNQADSAGRGP----LHHATILGHTGLACLFLKRGADL 666
Query: 628 MARDAHGNTALTYARQASSQECINVL 653
ARD+ G LT A + ++ + + +L
Sbjct: 667 GARDSEGRDPLTIAMETANADIVTLL 692
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 126 bits (316), Expect = 7e-29
Identities = 91/293 (31%), Positives = 143/293 (48%), Gaps = 20/293 (6%)
Query: 372 PHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAI---QSQILASLQSCES 428
P+A KK S N +T+HF+A ++ AW+ + + + L E
Sbjct: 377 PNAEDKKSFDLISHN---------RTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQ 427
Query: 429 SKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGT 488
S ++ L ++A+ ++ +Q + GN C DC + P W S NLG+L CIECSGIH +G
Sbjct: 428 SAGENSLEDLTKAI-IEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGV 486
Query: 489 RLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQT-KPSEKSTREEKERWIRSK 547
+SR++SLELD + ++GN+ N I E + + KP+ S ++ +I +K
Sbjct: 487 HISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAK 546
Query: 548 YEEKLFLAPLPCTELSLGQQLLWATADEDLQTAILLLAHGSR--EEVNETCGEGDGCTAL 605
Y + F T + +LL A DL I + A G E + E G+ G TAL
Sbjct: 547 YVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEP-GQELGETAL 605
Query: 606 HLACR---KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
HLA R + ++ L L+ ++ + A GNT L Y S EC+ +LL+
Sbjct: 606 HLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLR 658
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
Query: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
Query: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
Query: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 119 bits (298), Expect = 9e-27
Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 456 CVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
C DC +P WAS++ GVL+C EC +H SLG +S V+ L WP L +++ ++ ++
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 562 LSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
YG D + D +G T + YARQA E L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 119 bits (298), Expect = 9e-27
Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 17/214 (7%)
Query: 456 CVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSIGND 515
C DC +P WAS++ GVL+C EC +H SLG +S V+ L WP L +++ ++ ++
Sbjct: 11 CADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASN 70
Query: 516 LANSIWEGS-------SQGQTKPS-EKSTREEKERWIRSKYEEKLFLAPLPC------TE 561
ANSIWE S G+ K + + K +IR+KY+ F+ LPC T
Sbjct: 71 GANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTA 130
Query: 562 LSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLI 621
L +QL + +L+T + LL+ G++ G T LH+A + G + A+LL+
Sbjct: 131 KDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGTTPLHVAAKAGQTLQAELLV 187
Query: 622 WYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
YG D + D +G T + YARQA E L++
Sbjct: 188 VYGADPGSPDVNGRTPIDYARQAGHHELAERLVE 221
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 115 bits (289), Expect = 1e-25
Identities = 88/279 (31%), Positives = 134/279 (48%), Gaps = 24/279 (8%)
Query: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEA-----------MAL 444
+T+HF+A E +AWV +Q+ +L S + + S A + +
Sbjct: 361 RTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGSAGHDGEPHDLTKLLI 420
Query: 445 QSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELD-DWPV 503
+++ GN+ C DC +P W S NLGVL CI+CSG+H LG R SR++SL LD P
Sbjct: 421 AEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPS 480
Query: 504 ELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTE 561
EL + ++GN N + E S G KPS +S + +I +KY E F CT
Sbjct: 481 ELLLAL-NMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFAR--RCTP 537
Query: 562 LSLGQQLLWATADEDLQTAILLLAHGS--REEVNETCGEGDGCTALHLACRKGN---VVL 616
Q+L A + DL + + A+G + + + LHLA + N + L
Sbjct: 538 EP--QRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPL 595
Query: 617 AQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
+I G + A+ A GNTAL YA + +C+ +LL+
Sbjct: 596 VDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLK 634
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.127 0.379
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,525,575
Number of Sequences: 37866
Number of extensions: 1230709
Number of successful extensions: 5640
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 333
Number of HSP's successfully gapped in prelim test: 89
Number of HSP's that attempted gapping in prelim test: 4109
Number of HSP's gapped (non-prelim): 1432
length of query: 663
length of database: 18,247,518
effective HSP length: 109
effective length of query: 554
effective length of database: 14,120,124
effective search space: 7822548696
effective search space used: 7822548696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.