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Search of human proteins with 117553584
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
(1112 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 2194 0.0
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 1740 0.0
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 96 2e-19
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 96 2e-19
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 89 2e-17
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 82 2e-15
gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit... 78 5e-14
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 71 7e-12
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 70 8e-12
gi|217330641 IWS1 homolog [Homo sapiens] 69 3e-11
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 68 6e-11
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 68 6e-11
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 66 2e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 66 2e-10
gi|33356179 transcription termination factor, RNA polymerase I [... 65 4e-10
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 65 4e-10
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 65 5e-10
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 65 5e-10
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 65 5e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 65 5e-10
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 63 1e-09
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 63 1e-09
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 63 1e-09
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 63 2e-09
gi|148746195 trichohyalin [Homo sapiens] 62 2e-09
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 62 4e-09
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform... 62 4e-09
gi|125656165 THO complex 2 [Homo sapiens] 61 5e-09
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 61 7e-09
gi|221219020 NYD-SP11 protein [Homo sapiens] 60 1e-08
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 2194 bits (5686), Expect = 0.0
Identities = 1112/1112 (100%), Positives = 1112/1112 (100%)
Query: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC
Sbjct: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
Query: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL
Sbjct: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
Query: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIEPLTNLIHSTS 180
SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIEPLTNLIHSTS
Sbjct: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIEPLTNLIHSTS 180
Query: 181 AMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKIL 240
AMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKIL
Sbjct: 181 AMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKIL 240
Query: 241 KTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTT 300
KTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTT
Sbjct: 241 KTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTT 300
Query: 301 YRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI 360
YRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI
Sbjct: 301 YRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAI 360
Query: 361 RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRV 420
RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRV
Sbjct: 361 RKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRPRV 420
Query: 421 TTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQER 480
TTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQER
Sbjct: 421 TTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQER 480
Query: 481 ASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPL 540
ASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPL
Sbjct: 481 ASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPL 540
Query: 541 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 600
SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK
Sbjct: 541 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 600
Query: 601 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 660
RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK
Sbjct: 601 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 660
Query: 661 KGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLA 720
KGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLA
Sbjct: 661 KGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLA 720
Query: 721 DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDL 780
DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDL
Sbjct: 721 DSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDL 780
Query: 781 DFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEK 840
DFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEK
Sbjct: 781 DFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEK 840
Query: 841 EERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSL 900
EERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSL
Sbjct: 841 EERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSL 900
Query: 901 QEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNE 960
QEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNE
Sbjct: 901 QEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQLPPGVSNE 960
Query: 961 AQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKL 1020
AQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKL
Sbjct: 961 AQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSYLITTPCYSDAFAKL 1020
Query: 1021 LESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVK 1080
LESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVK
Sbjct: 1021 LESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMYSRSIQGHHVCLLVK 1080
Query: 1081 KGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1112
KGENSVSVDGKCSDSTLLSNLLEEMKATLAKC
Sbjct: 1081 KGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1112
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 1740 bits (4506), Expect = 0.0
Identities = 896/946 (94%), Positives = 896/946 (94%), Gaps = 50/946 (5%)
Query: 167 KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ 226
KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ
Sbjct: 258 KLIEPLTNLIHSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQ 317
Query: 227 NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV 286
NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV
Sbjct: 318 NLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIV 377
Query: 287 KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI 346
KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI
Sbjct: 378 KKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLI 437
Query: 347 AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ 406
AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ
Sbjct: 438 AAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQ 497
Query: 407 EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL 466
EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL
Sbjct: 498 EPHHTLEAMLRPRVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLMVDRL 557
Query: 467 PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV 526
PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV
Sbjct: 558 PQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPV 617
Query: 527 PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA 586
PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA
Sbjct: 618 PEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA 677
Query: 587 NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL 646
NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL
Sbjct: 678 NNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKL 737
Query: 647 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND 706
EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND
Sbjct: 738 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND 797
Query: 707 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 766
PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD
Sbjct: 798 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 857
Query: 767 KEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDK 826
KEKKKEKEKK
Sbjct: 858 KEKKKEKEKK-------------------------------------------------- 867
Query: 827 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE 886
KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE
Sbjct: 868 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE 927
Query: 887 NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG 946
NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG
Sbjct: 928 NSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDG 987
Query: 947 VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY 1006
VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY
Sbjct: 988 VPVPFQLPPGVSNEAQYVFTIQSIVMAQKLKGTLSFIAKNDEGATHEKLDFRLHFSCSSY 1047
Query: 1007 LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY 1066
LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY
Sbjct: 1048 LITTPCYSDAFAKLLESGDLSMSSIKVDGIRMSFQNLLAKICFHHHFSVVERVDSCASMY 1107
Query: 1067 SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1112
SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC
Sbjct: 1108 SRSIQGHHVCLLVKKGENSVSVDGKCSDSTLLSNLLEEMKATLAKC 1153
Score = 332 bits (851), Expect = 1e-90
Identities = 168/169 (99%), Positives = 168/169 (99%)
Query: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC
Sbjct: 1 MALKMVKGSIDRMFDKNLQDLVRGIRNHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC 60
Query: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL
Sbjct: 61 KLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDL 120
Query: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLI 169
SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKA LI
Sbjct: 121 SSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAVLI 169
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 95.5 bits (236), Expect = 2e-19
Identities = 52/153 (33%), Positives = 87/153 (56%), Gaps = 2/153 (1%)
Query: 18 LQDLVRGIRNHKE--DEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
L++L+R IR + +E + I + I+ ++++ + V KL Y+ MLGY +
Sbjct: 7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFG 66
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++ KFT KRIGYL A E DV +L TN I+ DL+ +Q+ G+AL L
Sbjct: 67 QLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTL 126
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAKL 168
C + ++ RDLA ++ L+ + Y+RKKA L
Sbjct: 127 GCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAAL 159
Score = 69.7 bits (169), Expect = 1e-11
Identities = 86/416 (20%), Positives = 169/416 (40%), Gaps = 69/416 (16%)
Query: 183 SLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKT 242
++LYE V T++ + + S L + L + ++D+N++Y+ L ++ K ++T
Sbjct: 290 AILYETVLTIMDI--------KSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQT 341
Query: 243 HPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 302
+VQ H+ I+ CL D D SI+ RA++L + +V+ N+ ++K+L+ +D E
Sbjct: 342 DHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKA 401
Query: 303 DELLTKIIDICSQSNY----QYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 358
D C+ + +Y + W+I ++ + G+ ++ +
Sbjct: 402 D---------CASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSV 452
Query: 359 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRP 418
+ + V ++ +L +Q+ ++ AAW GE+ + L E ++
Sbjct: 453 EMHAYTVQRLYKA-----ILGDYSQQ----PLVQVAAWCIGEYGDLLVSGQCEEEEPIQ- 502
Query: 419 RVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLM---------VDRLPQF 469
V V+ + S+L G A+T +M V+R+ +
Sbjct: 503 -----------VTEDEVLDILESVLISNMSTSVTRG-YALTAIMKLSTRFTCTVNRIKKV 550
Query: 470 V----QSADLEVQERA---SCILQLVKHIQKLQAKDVPVAEEVSALFAGEL----NPVAP 518
V S D+E+Q+RA + + + H++ + +PV E+V+ E+ P
Sbjct: 551 VSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEP 610
Query: 519 KAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 574
+ P P G + N+ L D P P +PS A E L
Sbjct: 611 APLETKPPPSGPQPTSQANDLLDLLGGNDITPVI------PTAPTSKPSSAGGELL 660
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 95.5 bits (236), Expect = 2e-19
Identities = 52/153 (33%), Positives = 87/153 (56%), Gaps = 2/153 (1%)
Query: 18 LQDLVRGIRNHKE--DEAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
L++L+R IR + +E + I + I+ ++++ + V KL Y+ MLGY +
Sbjct: 7 LRELIRTIRTARTQAEEREMIQKECAAIRSSFREEDNTYRCRNVAKLLYMHMLGYPAHFG 66
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++ KFT KRIGYL A E DV +L TN I+ DL+ +Q+ G+AL L
Sbjct: 67 QLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMTNCIKNDLNHSTQFVQGLALCTL 126
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAKL 168
C + ++ RDLA ++ L+ + Y+RKKA L
Sbjct: 127 GCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAAL 159
Score = 69.7 bits (169), Expect = 1e-11
Identities = 86/416 (20%), Positives = 169/416 (40%), Gaps = 69/416 (16%)
Query: 183 SLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKT 242
++LYE V T++ + + S L + L + ++D+N++Y+ L ++ K ++T
Sbjct: 287 AILYETVLTIMDI--------KSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQT 338
Query: 243 HPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 302
+VQ H+ I+ CL D D SI+ RA++L + +V+ N+ ++K+L+ +D E
Sbjct: 339 DHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKA 398
Query: 303 DELLTKIIDICSQSNY----QYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVK 358
D C+ + +Y + W+I ++ + G+ ++ +
Sbjct: 399 D---------CASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSV 449
Query: 359 AIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFSEHLQEPHHTLEAMLRP 418
+ + V ++ +L +Q+ ++ AAW GE+ + L E ++
Sbjct: 450 EMHAYTVQRLYKA-----ILGDYSQQ----PLVQVAAWCIGEYGDLLVSGQCEEEEPIQ- 499
Query: 419 RVTTLPGHIQAVYVQNVVKLYASILQQKEQAGEAEGAQAVTQLM---------VDRLPQF 469
V V+ + S+L G A+T +M V+R+ +
Sbjct: 500 -----------VTEDEVLDILESVLISNMSTSVTRG-YALTAIMKLSTRFTCTVNRIKKV 547
Query: 470 V----QSADLEVQERA---SCILQLVKHIQKLQAKDVPVAEEVSALFAGEL----NPVAP 518
V S D+E+Q+RA + + + H++ + +PV E+V+ E+ P
Sbjct: 548 VSIYGSSIDVELQQRAVEYNALFKKYDHMRSALLERMPVMEKVTTNGPTEIVQTNGETEP 607
Query: 519 KAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 574
+ P P G + N+ L D P P +PS A E L
Sbjct: 608 APLETKPPPSGPQPTSQANDLLDLLGGNDITPVI------PTAPTSKPSSAGGELL 657
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 89.0 bits (219), Expect = 2e-17
Identities = 75/275 (27%), Positives = 124/275 (45%), Gaps = 28/275 (10%)
Query: 18 LQDLVRGIRNHKED--EAKYISQCIDEIKQELKQDNIAVKANAVCKLTYLQMLGYDISWA 75
LQDL+ IR K E + I + I+ + + + + KL Y+ MLGY +
Sbjct: 8 LQDLIEEIRGAKTQAQEREVIQKECAHIRASFRDGDPVHRHRQLAKLLYVHMLGYPAHFG 67
Query: 76 AFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGL 135
++++++S+FT KR+GYL A E D +L TN I+ DLS Q G+AL L
Sbjct: 68 QMECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTL 127
Query: 136 SCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIE-------PLTNLIHSTSAMSLLYEC 188
S + ++ RDLA ++ L+ PY+RKKA L P + + LL+E
Sbjct: 128 STMGSAEMCRDLAPEVEKLLLQPSPYVRKKAILTAVHMIRKVPELSSVFLPPCAQLLHER 187
Query: 189 VNTVIAVLISLSSGMPNHSAS--------IQLCVQKLRILIE-----------DSDQNLK 229
+ ++ I+L + + S + + V LR L+ SD L+
Sbjct: 188 HHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSISGVSDPFLQ 247
Query: 230 YLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDES 264
L + + + H +S ++ DL+ Q + D S
Sbjct: 248 VQILRLLRILGRNHEESSETMNDLLAQVATNTDTS 282
Score = 56.2 bits (134), Expect = 2e-07
Identities = 43/203 (21%), Positives = 95/203 (46%), Gaps = 32/203 (15%)
Query: 212 LCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQSHKDLILQCLDDKDESIRLRALD 271
L V L + +SD+N++Y+ L ++ +++++ +VQ H+ +++CL + D S+ RAL+
Sbjct: 309 LAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRETDASLSRRALE 368
Query: 272 LLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISIL 331
L +V+ N+ ++++L ++ R + + I+ + ++ W+I +
Sbjct: 369 LSLALVNSSNVRAMMQELQAFLESCP-PDLRADCASGIL----LAAERFAPTKRWHIDTI 423
Query: 332 VELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQMSALLDSAHLLASSTQR---NGIC 388
+ + GT +R AV+ ++ L+ A L + + R N +
Sbjct: 424 LHVLTTAGTH------------------VRDDAVANLTQLIGGAQELHAYSVRRLYNALA 465
Query: 389 E------VLYAAAWICGEFSEHL 405
E ++ AAW GE+ + L
Sbjct: 466 EDISQQPLVQVAAWCIGEYGDLL 488
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 82.4 bits (202), Expect = 2e-15
Identities = 92/367 (25%), Positives = 158/367 (43%), Gaps = 34/367 (9%)
Query: 538 EPLSDSESEDERPRAVFHEEEQRRPKHR----PSEADEEELAR---RREARK-------- 582
E S + E + P V E+ + P P+EA E A+ + EA+
Sbjct: 563 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPV 622
Query: 583 QEQANNPFYIKS---SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEE 639
+E+A +P +KS + SP K +P P + + P K ++ K E+
Sbjct: 623 KEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE-EAKSPEKAKSPVKAE--AKSPEK 679
Query: 640 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM--PENAL-P 696
+ K E K + +++ K + +E +P + V EE PE A P
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 697 SDEDDKDPN---DPYRALDIDLDKPLADS---EKLPIQKHRNTETSKSPEKDVPMVEKKS 750
E+ K P P +A +D+ P A + E+ + E +KSP K+ +K+
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKA 799
Query: 751 KKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAP---APAPVPSTDECED 807
K P K++ K EKE K+++ + K E+ + PP A APA P T+E +D
Sbjct: 800 KSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPA-TPKTEEKKD 858
Query: 808 AKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQN 867
+K E +++ + + ++KK P +K K K + ++ + + K K P E A V+
Sbjct: 859 SKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKE 918
Query: 868 GAPEEEQ 874
A +E+
Sbjct: 919 DAKPKEK 925
Score = 79.0 bits (193), Expect = 2e-14
Identities = 84/365 (23%), Positives = 152/365 (41%), Gaps = 45/365 (12%)
Query: 539 PLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSP 598
P+ E+ ++ E + K + +E + + ++ +E+A +P + + SP
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSP---EKAKSP 725
Query: 599 QKRYQDTPGVEHIPVVQIDLSV-----PLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRK 653
K TP PV + S P K L + K + R +K +
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 654 KRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDP-NDPYRALD 712
K KE+ + P + D + PE +P E+ K P + + +
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDA-------------KAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 713 IDLDKP--LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKK 770
+ + +P A+ EK P + E S +++ P +K++ KPK +EKK E+ KE K
Sbjct: 833 VKVKEPPKKAEEEKAPATP-KTEEKKDSKKEEAP--KKEAPKPKVEEKKEPAVEKPKESK 889
Query: 771 KE-KEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQD----QD 825
E K+++AED P APA V + ++ A+ E DDA+ ++ +
Sbjct: 890 VEAKKEEAEDKK---KVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Query: 826 KKSPKPKKKKHRKEK----EERTKGKKKSKK------QPPGSEEAAGEPVQNGAPEEEQL 875
KK P+KK ++EK EE+ K + K+K+ + P +A + +++
Sbjct: 947 KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSK 1006
Query: 876 PPESS 880
PPE +
Sbjct: 1007 PPEKA 1011
Score = 75.9 bits (185), Expect = 2e-13
Identities = 91/400 (22%), Positives = 162/400 (40%), Gaps = 41/400 (10%)
Query: 517 APKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELAR 576
+P+ + K PV E A E S + E + P V E+ + P +++ E
Sbjct: 511 SPEKEAKSPVKEEAKSPA---EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA--- 564
Query: 577 RREARKQEQANNPFYIKS---SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
++ ++E+A +P +KS + SP K +P P P+K ++
Sbjct: 565 --KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPE---KAKSPVKEEAKSPAEAK 619
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 693
++EE + +++ ++ K ++E K + S E + A+ + PE
Sbjct: 620 SPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEK 679
Query: 694 AL-PSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKH-RNTETSKSPEKDVPMVEKKSK 751
A P + K P + + P + K P+++ ++ E +KSP K+ +K+K
Sbjct: 680 AKSPVKAEAKSPEKAKSPVKEEAKSP--EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737
Query: 752 KPKKKEKKHKEKERDKEKKKEKEKKA--------EDLDFWLSTTPPPAPAPAPAPVPSTD 803
P K+E K EK + EK K + K+ E+ P A +P V S +
Sbjct: 738 SPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPE 797
Query: 804 EC-----EDAKTEAQGEEDDAEGQDQDKKSPKPK----KKKHRKEKEER------TKGKK 848
+ EDAK + E + K+ KP+ K+ +K +EE+ T+ KK
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 849 KSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENS 888
SKK+ +EA V+ + P ES E +
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEA 897
Score = 73.6 bits (179), Expect = 1e-12
Identities = 96/409 (23%), Positives = 160/409 (39%), Gaps = 53/409 (12%)
Query: 488 VKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESED 547
+K ++K + + V V E+ E V + +K+ EG + + E E E
Sbjct: 444 IKVVEKSEKETVIVEEQTEETQVTE--EVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEET 501
Query: 548 ERPRAVFHEEEQRRPKHRPSEADEEELARRREAR--KQEQANNPFYIKS---SPSPQKRY 602
+ P A EE P+ +EE EA+ ++E+A +P +KS + SP K
Sbjct: 502 KSPPA----EEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 557
Query: 603 QDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLE-KDKRRKKRKEKEKK 661
+P P + K P VK E+ + K E K K EK K
Sbjct: 558 AKSP-----PEAKSPEKEEAKSPA------EVKSPEKAKSPAKEEAKSPAEAKSPEKAKS 606
Query: 662 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD 721
+ + P E+ + + + + P+ E+ K P + P +
Sbjct: 607 PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP--E 664
Query: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLD 781
K P++ +KSPEK V+ ++K P+K + KE+ + EK K K+
Sbjct: 665 KAKSPVKAE-----AKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK-- 717
Query: 782 FWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHR--KE 839
+P A +PV E+AKT + + E +K+ P+K K K
Sbjct: 718 ---------SPEKAKSPVK-----EEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKS 763
Query: 840 KEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENS 888
E +T K++++ E A PV +EE PE + S L E++
Sbjct: 764 PEAKTPAKEEARSPADKFPEKAKSPV-----KEEVKSPEKAKSPLKEDA 807
Score = 65.1 bits (157), Expect = 4e-10
Identities = 82/361 (22%), Positives = 148/361 (40%), Gaps = 35/361 (9%)
Query: 514 NPVAPKAQK----KVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEA 569
+PV +A+ K PV E P+ + E+ ++ +EE + P+ S
Sbjct: 682 SPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV-KEEAKTPEKAKSPV 740
Query: 570 DEEELARRREARKQEQANNPFYIKS--SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGL 627
EE A+ E K + +KS + +P K +P + + + +K P
Sbjct: 741 KEE--AKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK 798
Query: 628 PMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVT 687
S +K + + ++ +K++ + KE+EK + + P +++E+ APA
Sbjct: 799 AKSP--LKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPAT------ 850
Query: 688 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLP-IQKHRNTETSKSPEKDVPMV 746
P E+ KD A + KP + +K P ++K + ++ E+
Sbjct: 851 --------PKTEEKKDSKKE-EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE----A 897
Query: 747 EKKSKKP---KKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTD 803
E K K P K+ K + KE K K+K + K E D PA AP
Sbjct: 898 EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDT 957
Query: 804 ECEDAKTEAQGEEDDAEGQDQDKK-SPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAG 862
+ E AK + + +A+ ++ DK S +P K K K ++ + +K SK +E+ A
Sbjct: 958 KEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAA 1017
Query: 863 E 863
+
Sbjct: 1018 K 1018
Score = 63.9 bits (154), Expect = 8e-10
Identities = 74/312 (23%), Positives = 125/312 (40%), Gaps = 44/312 (14%)
Query: 519 KAQKKVPVPE-GLDLDAWINEPLSDSESEDERPRAVFHE-------EEQRRPKHRPSEAD 570
K+ +K PE LD E + ++ E P F E EE + P+ S
Sbjct: 745 KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK 804
Query: 571 EEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMS 630
E+ A +E K+E+ +P +K PQ+ P + + K P P +
Sbjct: 805 EDAKAPEKEIPKKEEVKSP--VKEEEKPQEVKVKEPPKK---------AEEEKAPATPKT 853
Query: 631 DQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM 690
++ ++E +++ K K +K++ +K P ES + + D
Sbjct: 854 EEKKDSKKEEAPKKEAPKPKVEEKKEPAVEK--------PKESKVEAKKEEAEDKKKVPT 905
Query: 691 PENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 750
PE P+ + K+ P EK + K + + +K+ E P EKK
Sbjct: 906 PEKEAPAKVEVKEDAKP--------------KEKTEVAK-KEPDDAKAKEPSKP-AEKKE 949
Query: 751 KKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKT 810
P+KK+ K +EK + E+K + E KA++ D LS P A STD+ +
Sbjct: 950 AAPEKKDTK-EEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Query: 811 EAQGEEDDAEGQ 822
E E+ A+G+
Sbjct: 1009 EKATEDKAAKGK 1020
Score = 60.8 bits (146), Expect = 7e-09
Identities = 67/309 (21%), Positives = 126/309 (40%), Gaps = 30/309 (9%)
Query: 607 GVEHIPVVQIDLSVPL--KVPGLPMSDQYVKLEEERRHRQKL------EKDKRRKKRKEK 658
G+ IP V + V K+ + S++ + EE+ ++ E++K K+ + K
Sbjct: 425 GLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGK 484
Query: 659 EKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKP 718
E++G + E + PA++ +E P E+ K P + + P
Sbjct: 485 EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKS---PVKEEAKSPAEAKSPEKEEAKSP 541
Query: 719 LA----DSEKLPIQKH-RNTETSKSPEKDVPMVE------KKSKKPKKKEKKH----KEK 763
+ K P ++ ++ +KSPEK+ +K+K P K+E K K
Sbjct: 542 AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601
Query: 764 ERDKEKKKEKEKKAEDLDFWL---STTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAE 820
E+ K KE+ K + + + +P +P A P+ +E + + E+++A+
Sbjct: 602 EKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 821 GQDQDKKSPKPKKKKHRKEKEE-RTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPES 879
++ K K + K K K + + K K + P EEA +EE PE
Sbjct: 662 SPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK 721
Query: 880 SYSLLAENS 888
+ S + E +
Sbjct: 722 AKSPVKEEA 730
Score = 55.5 bits (132), Expect = 3e-07
Identities = 65/276 (23%), Positives = 115/276 (41%), Gaps = 60/276 (21%)
Query: 637 EEERRHRQKLE-KDKRRKKRKEKEKKGKRRHSSLPTESDEDIAP----AQQVDIVTEEMP 691
EE +R++L+ + + K + +R+ S L DIA QQ+D
Sbjct: 316 EEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTK 375
Query: 692 ENALPSDEDDKDPNDPYRALDIDLDK-----------------PLADSEKLPIQKHRNTE 734
+ +D + ALDI++ P + E LP +T
Sbjct: 376 WEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTH 435
Query: 735 TSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAP 794
E+ + +VEK K+ E++ +E + +E +E+EK+A++
Sbjct: 436 IKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE--------------- 480
Query: 795 APAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKK-- 852
E+ K E GEE++AEG +++ KSP P ++ EKE ++ K+++K
Sbjct: 481 -----------EEGKEEEGGEEEEAEGGEEETKSP-PAEEAASPEKEAKSPVKEEAKSPA 528
Query: 853 --QPPGSEEA-------AGEPVQNGAPEEEQLPPES 879
+ P EEA + E ++ A EE + PPE+
Sbjct: 529 EAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Score = 49.3 bits (116), Expect = 2e-05
Identities = 39/205 (19%), Positives = 91/205 (44%), Gaps = 3/205 (1%)
Query: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD-KEKKKEKEKKAEDL 780
S + ++ + + EK+ +VE+++++ + E+ +E+E++ KE++ ++E+ E+
Sbjct: 433 STHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEE 492
Query: 781 DFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEK 840
+ +P A P + K EA+ + + ++ KSP K + +
Sbjct: 493 EAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKS 552
Query: 841 EERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE-NSYVKMTCDIRGS 899
+ + K + + P EEA P + +PE+ + P + AE S K ++
Sbjct: 553 PAKEEAKSPPEAKSPEKEEAK-SPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE 611
Query: 900 LQEDSQVTVAIVLENRSSSILKGME 924
+ ++ + E +S + +K E
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPE 636
>gi|37675283 adaptor-related protein complex 4, epsilon 1 subunit
[Homo sapiens]
Length = 1137
Score = 77.8 bits (190), Expect = 5e-14
Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 4/159 (2%)
Query: 14 FDKNLQDLVRGIR--NHKEDEAKYISQCIDEIKQELKQDNIAVKANAVC--KLTYLQMLG 69
F L LVRGI K +E K I Q + +K + +K C +L Y +MLG
Sbjct: 32 FSSRLGSLVRGITALTSKHEEEKLIQQELSSLKATVSAPTTTLKMMKECMVRLIYCEMLG 91
Query: 70 YDISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTG 129
YD S+ + I++ KR+GYLA S HE ++++L N + KDL S + +
Sbjct: 92 YDASFGYIHAIKLAQQGNLLEKRVGYLAVSLFLHESHELLLLLVNTVVKDLQSTNLVEVC 151
Query: 130 VALTGLSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKL 168
+ALT +S ++ + I + H+K +R+KA L
Sbjct: 152 MALTVVSQIFPCEMIPAVLPLIEDKLQHSKEIVRRKAVL 190
Score = 69.3 bits (168), Expect = 2e-11
Identities = 52/227 (22%), Positives = 105/227 (46%), Gaps = 26/227 (11%)
Query: 183 SLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKT 242
++L+ECV+TV ++ S ++ + + + NLKYLGL A++ +++
Sbjct: 315 AILFECVHTVYSIYPK--------SELLEKAAKCIGKFVLSPKINLKYLGLKALTYVIQQ 366
Query: 243 HPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYR 302
P H+ I++CLD D I+ L+LLY + + +N+ IV+K++ ++ +++
Sbjct: 367 DPTLALQHQMTIIECLDHPDPIIKRETLELLYRITNAQNITVIVQKMLEYLHQSKEEYVI 426
Query: 303 DELLTKIIDICSQSNYQYITNFEWYISILVELTRLEG-TRHGHL------IAAQMLDVAI 355
L+ KI ++ +Y + W+I + + + G H + + A+ D
Sbjct: 427 VNLVGKIAELAE----KYAPDNAWFIQTMNAVFSVGGDVMHPDIPNNFLRLLAEGFDDET 482
Query: 356 RVKAIRKFAVSQMSALLDSAHLLASSTQRNGICEVLYAAAWICGEFS 402
+ +R +AV LLD ++ L +W+ GE+S
Sbjct: 483 EDQQLRLYAVQSYLTLLDMENVFYPQ-------RFLQVMSWVLGEYS 522
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 70.9 bits (172), Expect = 7e-12
Identities = 63/264 (23%), Positives = 125/264 (47%), Gaps = 29/264 (10%)
Query: 618 LSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDI 677
+S P P + ++ KL ++KL+K+ + K +K+++++ + R E D++
Sbjct: 497 VSPPTPEPLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDRER------EKDKNK 550
Query: 678 APAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSK 737
+++ D V E+ + E ++ P++ L + AD K I++ + +
Sbjct: 551 DKSKEKDKVKEKEKDK-----ETGRETKYPWKEF---LKEEEADPYKFKIKEFEDVDPKV 602
Query: 738 SPEKDVPMVEKKSKKPKKKEKKHKEKERDK-EKKKEKEKKAEDL-------------DFW 783
+ + EK+ K KKK+++ +K++DK EK+K K+K ED +
Sbjct: 603 KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELA 662
Query: 784 LSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKE-E 842
L P + PA +PS K + E+ + + +DKK K KK+K +++KE E
Sbjct: 663 LPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKE 722
Query: 843 RTKGKKKSKKQPPGSEEAAGEPVQ 866
R K K++ +K+ E+ E ++
Sbjct: 723 REKEKREREKREKEKEKHKHEKIK 746
Score = 68.6 bits (166), Expect = 3e-11
Identities = 65/283 (22%), Positives = 117/283 (41%), Gaps = 31/283 (10%)
Query: 515 PVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 574
P+ ++K +P +++ + + L + E+ R E+++ + K + + +E+
Sbjct: 504 PLHKVYEEKTKLPSSVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKE 563
Query: 575 ARRREARKQEQANNPFYIKSSPSPQK-RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
+ R+ + F + P K + ++ V+ P + + D
Sbjct: 564 KDKETGRETKYPWKEFLKEEEADPYKFKIKEFEDVD---------------PKVKLKDGL 608
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 693
V+ E+E+ KDK++ + K K+ K KR + + ED A +V
Sbjct: 609 VRKEKEKH------KDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLV------- 655
Query: 694 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKP 753
LP E P A + P LP + E K EK EKK KK
Sbjct: 656 -LPPKELALPLFSPATASRVPAMLPSL-LPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKE 713
Query: 754 KKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAP 796
K+KEKK KE+E++K +++++EK+ E P A AP+P
Sbjct: 714 KEKEKKEKEREKEKREREKREKEKEKHKHEKIKVEPVALAPSP 756
Score = 48.5 bits (114), Expect = 3e-05
Identities = 51/211 (24%), Positives = 87/211 (41%), Gaps = 23/211 (10%)
Query: 683 VDIVTEEMPENALPSDEDDKDPNDPYRALDI-------DLDKPLADSEKLPIQKHRNTET 735
+D +E+ A + PN PY + L K + KLP + E
Sbjct: 466 MDASIDEVVRKAKLGTPSNMPPNFPYISSPSVSPPTPEPLHKVYEEKTKLP----SSVEV 521
Query: 736 SKSPEKDVPMVEKKSKKPKKKEK---KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAP 792
K +K++ KK +K + +E+ K+K+K ++K+K KEKEK E T
Sbjct: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKE--------TGRETK 573
Query: 793 APAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKK 852
P + +E + K + + ED + +K+KH+ +K++R KGKK K
Sbjct: 574 YPWKEFLKE-EEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKGKKDKDK 632
Query: 853 QPPGSEEAAGEPVQNGAPEEEQLPPESSYSL 883
+ + G + AP + P +L
Sbjct: 633 REKEKVKDKGREDKMKAPAPPLVLPPKELAL 663
Score = 38.5 bits (88), Expect = 0.036
Identities = 80/373 (21%), Positives = 136/373 (36%), Gaps = 65/373 (17%)
Query: 618 LSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKE-------KKGKRRHSSLP 670
++ P ++P P+S V + Q KD +K + + + +P
Sbjct: 90 VTFPHQIPSFPVSKNNVL-----QFPQPGSKDAEERKEYIPDYLPPIVSSQEEEEEEQVP 144
Query: 671 TESDEDIAPAQQVDIVTE-EMPENALPSDED--DKDPNDPYRALDIDLDKPLADSEKLPI 727
T+ A A QV + + E+ E + +DE+ K P LD P ++E+LP
Sbjct: 145 TDGGTS-AEAMQVPLEEDDELEEEEIINDENFLGKRP----------LDSP--EAEELPA 191
Query: 728 QKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTT 787
K ++K DV ++E + +K + + D +
Sbjct: 192 MKRPRLLSTKGDTLDVVLLEAREPLSSINTQKIPPMLSPVHVQ-------DSTDLAPPSP 244
Query: 788 PPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPK----------PKKKKHR 837
PP AP T + + K+ + Q KSPK P +
Sbjct: 245 EPPMLAPVAKSQMPTAKPLETKSFTPKTKTKTSSPGQKTKSPKTAQSPAMVGSPIRSPKT 304
Query: 838 KEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYS--LLAENSYVK--MT 893
KE+++ G+ KS K P + P PE P ++ S + E VK T
Sbjct: 305 VSKEKKSPGRSKSPKSPKSPKVTTHIPQTPVRPETPNRTPSATLSEKISKETIQVKQIQT 364
Query: 894 CDIRGSLQEDSQVTVAIVLENRSSSILKGMELSVLDSLNARMARPQGSSVHDGVPVPFQL 953
G L ++Q A+V + K +E S+ D++ AR + + P PF+
Sbjct: 365 PPDAGKLNSENQPKKAVVAD-------KTIEASI-DAVIAR-------ACAEREPDPFEF 409
Query: 954 PPGVSNEAQYVFT 966
G +E +FT
Sbjct: 410 SSGSESEGD-IFT 421
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 70.5 bits (171), Expect = 8e-12
Identities = 52/246 (21%), Positives = 120/246 (48%), Gaps = 28/246 (11%)
Query: 135 LSCFVTPDLARDLANDIMTLMSHTKPYIRKKAKLIEPLTNLIHSTSAMSLLYECVNTVIA 194
L C+ PD A + ++ I KA+ + HS + ++L+E ++ +I
Sbjct: 265 LQCYPPPDPA------VRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLII- 317
Query: 195 VLISLSSGMPNHSASIQLCVQ---KLRILIEDSDQNLKYLGLLAMSKILKTH--PKSVQS 249
+H + L V+ +L ++ + NL+YL L +M + + ++V++
Sbjct: 318 ----------HHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKT 367
Query: 250 HKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHVDKAEGTTYRDELLTK 308
H + ++ L ++D S+R RA+DLLY M + N +IV +++++++ A+ + R+E++ K
Sbjct: 368 HIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETAD-YSIREEIVLK 426
Query: 309 IIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDVAIRVKAIRKFAVSQM 368
+ + +Y ++ WY+ ++ L R+ G + +++ + I ++ +A +
Sbjct: 427 VAILAE----KYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTV 482
Query: 369 SALLDS 374
L +
Sbjct: 483 FEALQA 488
Score = 69.3 bits (168), Expect = 2e-11
Identities = 65/287 (22%), Positives = 132/287 (45%), Gaps = 31/287 (10%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++++T K+IGYL S + +++I L N I+ DL+S + G+
Sbjct: 71 DIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGL 130
Query: 131 ALTGLSCFVTPDLARDLANDI--MTLMSHTKPYIRKKAKLIEPLTNLIHSTSAMSLLYEC 188
AL ++ + ++A A +I + + T +++ A L L L ++ + + +
Sbjct: 131 ALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALC--LLRLYRTSPDLVPMGDW 188
Query: 189 VNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQ 248
+ V+ +L G+ + S+ + L + + + K LA+S++ + +
Sbjct: 189 TSRVVHLLNDQHLGVVTAATSL------ITTLAQKNPEEFKTSVSLAVSRLSRIVTSAST 242
Query: 249 SHKDL----------------ILQCLDDKDESIRLRALDLLYGMVSK 279
+D +LQC D ++R R + L +++K
Sbjct: 243 DLQDYTYYFVPAPWLSVKLLRLLQCYPPPDPAVRGRLTECLETILNK 289
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 68.6 bits (166), Expect = 3e-11
Identities = 78/336 (23%), Positives = 139/336 (41%), Gaps = 39/336 (11%)
Query: 539 PLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSP 598
P SDSE+ED + E + P+H+ S+++ EE + R + + + P P
Sbjct: 168 PASDSETEDALKPQISDSESEEPPRHQASDSENEEPPKPRMSDSESE--------ELPKP 219
Query: 599 QKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEK 658
Q ++ E P Q S ++P +SD + E+ RH+ +++ K +
Sbjct: 220 QVSDSES---EEPPRHQASDSENEELPKPRISDS--ESEDPPRHQASDSENEELPKPRIS 274
Query: 659 EKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKP 718
+ + + + ++S+ + P +V E P+ SD + +D + KP
Sbjct: 275 DSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASDSETEDASR-------HKQKP 327
Query: 719 LADSEKLPIQKHRNTE-TSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDK---EKKKEKE 774
+D + K +TE + S D M KK +E++HK+++ D EK+ E+E
Sbjct: 328 ESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEE 387
Query: 775 KKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK 834
K A+ LS + A A K+ + DD++ KS K +K
Sbjct: 388 KVAKRKAAVLSDSEDEEKASA------------KKSRVVSDADDSDSDAVSDKSGKREKT 435
Query: 835 KHRKEKEERTK---GKKKSKKQPPGSEEAAGEPVQN 867
+EE K KK +K GS+ +G +N
Sbjct: 436 IASDSEEEAGKELSDKKNEEKDLFGSDSESGNEEEN 471
Score = 56.2 bits (134), Expect = 2e-07
Identities = 77/369 (20%), Positives = 145/369 (39%), Gaps = 50/369 (13%)
Query: 533 DAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYI 592
D +N SDSES EE R K SE++E R E + N
Sbjct: 72 DEPLNLNASDSES-----------EELHRQKDSDSESEE-----RAEPPASDSENEDVNQ 115
Query: 593 KSSPSPQKRYQDTPGV----EHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEK 648
S S + + PG E + S V P SD ++ ++ +
Sbjct: 116 HGSDSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETE 175
Query: 649 DKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPY 708
D + + + E + RH + +E++E P + D +EE+P+ + E ++ P +
Sbjct: 176 DALKPQISDSESEEPPRHQASDSENEEPPKP-RMSDSESEELPKPQVSDSESEEPPR--H 232
Query: 709 RALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS-KKPKKKEKKHKEKERDK 767
+A D +++E+LP + ++E+ P E + KP+ + + ++ R++
Sbjct: 233 QASD-------SENEELPKPRISDSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQ 285
Query: 768 EKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDEC----------EDAKTEAQGEED 817
E E+ + +S + P PA T++ +D+ E +GE+
Sbjct: 286 ASDSENEELPKPR---VSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDRENKGEDT 342
Query: 818 DAEGQDQDKKSPKPKKKKHRKEKEERTKGKKK---SKKQPPGSEEAAGE---PVQNGAPE 871
+ + S +KK H + EE K+K + + G EE + V + + +
Sbjct: 343 EMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSED 402
Query: 872 EEQLPPESS 880
EE+ + S
Sbjct: 403 EEKASAKKS 411
Score = 42.0 bits (97), Expect = 0.003
Identities = 47/257 (18%), Positives = 98/257 (38%), Gaps = 26/257 (10%)
Query: 626 GLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDI 685
GLP E + + + ++K+ + + P SD + Q
Sbjct: 59 GLPKGHHVTDSENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGS 118
Query: 686 VTEEMPENALPSDEDDKDPNDPYRALDIDLDK----PLADSEKLPIQKHRNTETSKSPEK 741
+E LP + + + A D + + P +DSE +QK +++
Sbjct: 119 DSESEETRKLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDAL 178
Query: 742 DVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPS 801
+ + +S++P + + E E + K + + ++E+L P P + + + P
Sbjct: 179 KPQISDSESEEPPRHQASDSENE-EPPKPRMSDSESEEL-------PKPQVSDSESEEPP 230
Query: 802 TDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA 861
+ D++ E + ++ + +D P+ + E EE K P S+ +
Sbjct: 231 RHQASDSENEELPKPRISDSESED----PPRHQASDSENEELPK--------PRISDSES 278
Query: 862 GEPVQNGA--PEEEQLP 876
+P +N A E E+LP
Sbjct: 279 EDPPRNQASDSENEELP 295
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 67.8 bits (164), Expect = 6e-11
Identities = 46/201 (22%), Positives = 101/201 (50%), Gaps = 16/201 (7%)
Query: 177 HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAM 236
HS + ++L+E ++ +I PN ++ C Q L ++ + NL+YL L +M
Sbjct: 302 HSNAKNAILFETISLIIHY-----DSEPN--LLVRACNQ-LGQFLQHRETNLRYLALESM 353
Query: 237 SKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHV 293
+ + ++V++H D ++ L ++D S+R RA DLLY M + N +IV +++ ++
Sbjct: 354 CTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYL 413
Query: 294 DKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDV 353
+ A+ R+E++ K+ + +Y ++ WY+ ++ L R+ G + ++L +
Sbjct: 414 ETAD-YAIREEIVLKVAILAE----KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQI 468
Query: 354 AIRVKAIRKFAVSQMSALLDS 374
++ +A + L +
Sbjct: 469 VTNRDDVQGYAAKTVFEALQA 489
Score = 64.7 bits (156), Expect = 5e-10
Identities = 58/242 (23%), Positives = 114/242 (47%), Gaps = 12/242 (4%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++K+T K+IGYL S + +++I L N I+ DL+S + +
Sbjct: 71 DIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130
Query: 131 ALTGLSCFVTPDLARDLANDIMTLM--SHTKPYIRKKAKLIEPLTNLIHSTSAMSLLYEC 188
AL ++ + ++ A DI ++ + +++ A L L L ++ + + E
Sbjct: 131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALC--LLRLYKASPDLVPMGEW 188
Query: 189 VNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQ 248
V+ +L G+ + S+ C+ K D + L + +S+I+ + +Q
Sbjct: 189 TARVVHLLNDQHMGVVTAAVSLITCLCKKN---PDDFKTCVSLAVSRLSRIVSSASTDLQ 245
Query: 249 SH 250
+
Sbjct: 246 DY 247
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 67.8 bits (164), Expect = 6e-11
Identities = 46/201 (22%), Positives = 101/201 (50%), Gaps = 16/201 (7%)
Query: 177 HSTSAMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAM 236
HS + ++L+E ++ +I PN ++ C Q L ++ + NL+YL L +M
Sbjct: 302 HSNAKNAILFETISLIIHY-----DSEPN--LLVRACNQ-LGQFLQHRETNLRYLALESM 353
Query: 237 SKILKTH--PKSVQSHKDLILQCLD-DKDESIRLRALDLLYGMVSKKNLMEIVKKLMTHV 293
+ + ++V++H D ++ L ++D S+R RA DLLY M + N +IV +++ ++
Sbjct: 354 CTLASSEFSHEAVKTHIDTVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVSEMLRYL 413
Query: 294 DKAEGTTYRDELLTKIIDICSQSNYQYITNFEWYISILVELTRLEGTRHGHLIAAQMLDV 353
+ A+ R+E++ K+ + +Y ++ WY+ ++ L R+ G + ++L +
Sbjct: 414 ETAD-YAIREEIVLKVAILAE----KYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVLQI 468
Query: 354 AIRVKAIRKFAVSQMSALLDS 374
++ +A + L +
Sbjct: 469 VTNRDDVQGYAAKTVFEALQA 489
Score = 64.7 bits (156), Expect = 5e-10
Identities = 58/242 (23%), Positives = 114/242 (47%), Gaps = 12/242 (4%)
Query: 16 KNLQDLVRGIRN--HKEDEAKYISQCIDEIKQELKQDNIA---VKANAVCKLTYLQMLGY 70
+ L + IRN KE E K I++ + I+ + K D K VCKL ++ +LG+
Sbjct: 11 RGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGH 70
Query: 71 DISWAAFNIIEVMSASKFTFKRIGYLAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGV 130
DI + + ++S++K+T K+IGYL S + +++I L N I+ DL+S + +
Sbjct: 71 DIDFGHMEAVNLLSSNKYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCL 130
Query: 131 ALTGLSCFVTPDLARDLANDIMTLM--SHTKPYIRKKAKLIEPLTNLIHSTSAMSLLYEC 188
AL ++ + ++ A DI ++ + +++ A L L L ++ + + E
Sbjct: 131 ALHCIANVGSREMGEAFAADIPRILVAGDSMDSVKQSAALC--LLRLYKASPDLVPMGEW 188
Query: 189 VNTVIAVLISLSSGMPNHSASIQLCVQKLRILIEDSDQNLKYLGLLAMSKILKTHPKSVQ 248
V+ +L G+ + S+ C+ K D + L + +S+I+ + +Q
Sbjct: 189 TARVVHLLNDQHMGVVTAAVSLITCLCKKN---PDDFKTCVSLAVSRLSRIVSSASTDLQ 245
Query: 249 SH 250
+
Sbjct: 246 DY 247
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/357 (23%), Positives = 144/357 (40%), Gaps = 47/357 (13%)
Query: 543 SESEDERPRAVFHEEEQRRPKHRP-----SEADEEELARRREARKQEQANNPFYIKSSPS 597
+E ++E P A EEE+ K P E EEE + E ++E+ KS +
Sbjct: 492 AEEKEEEPEA---EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548
Query: 598 PQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKE 657
+ + E Q + + G + K EE+ +++ + E
Sbjct: 549 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 608
Query: 658 KEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDK 717
K +K K S +P E+ + EE ++ +P ++ P
Sbjct: 609 KPEKAK---SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK------S 659
Query: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK----KPKKKEKKHKE-KERDKEKKKE 772
P+ + K P+ K E +KSP P+ E KSK K ++KE++ KE KE KE+K E
Sbjct: 660 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719
Query: 773 -KEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKP 831
KE+K +D+ P A +PV + + T + + E + +++ P
Sbjct: 720 KKEEKPKDV---------PEKKKAESPV-KEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 769
Query: 832 KKKKHRK-------EKEERTKGKKKSKKQP-------PGSEEAAGEPVQNGAPEEEQ 874
++K+ K E+E KG K S+K+ G EE E + G+ EE+
Sbjct: 770 QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 826
Score = 57.8 bits (138), Expect = 6e-08
Identities = 61/287 (21%), Positives = 118/287 (41%), Gaps = 40/287 (13%)
Query: 609 EHIPVVQIDLSV-----------------------------PLKVPGLPMSDQYVKLEEE 639
E + + +L+V P+K + ++ + EEE
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 530
Query: 640 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQ-QVDIVTEEMPENALPSD 698
++ E+D+ K + +E ++ SS E +++ + + + E E +
Sbjct: 531 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 590
Query: 699 EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK 758
+ ++ D ++KP + K P+ K E KSP P VE+K K P K
Sbjct: 591 KSEEVATKEELVADAKVEKP--EKAKSPVPKSPVEEKGKSPVPKSP-VEEKGKSPVPKSP 647
Query: 759 KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDD 818
+EK + K E+K + + P A +PVP + E+AK++A+ + +
Sbjct: 648 V-EEKGKSPVPKSPVEEKGKS-----PVSKSPVEEKAKSPVPKS-PVEEAKSKAEVGKGE 700
Query: 819 AEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
+ +++ + PK++K K++E+ +K K + P EEA E V
Sbjct: 701 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 747
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/170 (22%), Positives = 80/170 (47%), Gaps = 18/170 (10%)
Query: 715 LDKPLADSEKLPIQK---HRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKK 771
+ KP ++ KL +Q E +K ++ M E + ++ KE++++ ++K
Sbjct: 436 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 495
Query: 772 EKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKP 831
E+E +AE+ + +P A AP E +GE+++ EGQ+++++ +
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAP-------------EVKEEEGEKEEEEGQEEEEEEDEG 542
Query: 832 KKKKHRKE--KEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPES 879
K +E E+ +K+ +Q G EA E + A EE+++ +S
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 592
Score = 47.4 bits (111), Expect = 8e-05
Identities = 80/398 (20%), Positives = 148/398 (37%), Gaps = 75/398 (18%)
Query: 516 VAPKAQK-KVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 574
++ K QK KV P+ ++ E + +++ EDE+ A EEL
Sbjct: 432 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM-----------EEALTAITEEL 480
Query: 575 ARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYV 634
A + K+E A ++ P E V P+K + ++
Sbjct: 481 AVSMKEEKKEAAEEK-------------EEEPEAEEEEVAA--KKSPVKATAPEVKEEEG 525
Query: 635 KLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQ-QVDIVTEEMPEN 693
+ EEE ++ E+D+ K + +E ++ SS E +++ + + + E E
Sbjct: 526 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 585
Query: 694 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKP 753
++ ++ D ++KP + K P+ K E KSP P VE+K K P
Sbjct: 586 KKVEEKSEEVATKEELVADAKVEKP--EKAKSPVPKSPVEEKGKSPVPKSP-VEEKGKSP 642
Query: 754 KKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQ 813
K P +PVP + E +
Sbjct: 643 VPKS--------------------------------PVEEKGKSPVPK------SPVEEK 664
Query: 814 GEEDDAEGQDQDK-KSPKPKKK-KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 871
G+ ++ ++K KSP PK + K K E KG++K +++ E E V+ +
Sbjct: 665 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 724
Query: 872 EEQLP----PESSYSLLAENSYVKMTCDIRGSLQEDSQ 905
+ +P ES A V +T ++ L+++++
Sbjct: 725 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 762
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/240 (21%), Positives = 99/240 (41%), Gaps = 27/240 (11%)
Query: 642 HRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDD 701
HR + + +K K + K K +H + E+I +V+ EM E E+
Sbjct: 426 HRPPITISSKIQKPKVEAPKLKVQHKFV-----EEIIEETKVEDEKSEMEEALTAITEE- 479
Query: 702 KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHK 761
A+ + +K A EK ++ E + K P+ K+ P+ KE++ +
Sbjct: 480 -------LAVSMKEEKKEAAEEK---EEEPEAEEEEVAAKKSPV---KATAPEVKEEEGE 526
Query: 762 EKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEG 821
++E + ++++E+E + D + E E+ +TEA+ E ++AE
Sbjct: 527 KEEEEGQEEEEEEDEGAKSD----QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 582
Query: 822 QDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPP----GSEEAAGEPVQNGAPEEEQLPP 877
+++ K K ++ ++E K +K K + P EE PV EE+ P
Sbjct: 583 KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 642
Score = 37.4 bits (85), Expect = 0.080
Identities = 60/273 (21%), Positives = 104/273 (38%), Gaps = 51/273 (18%)
Query: 514 NPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEE 573
+PV KA+ VP P+ +++S+ E + EEE++ K P EE+
Sbjct: 672 SPVEEKAKSPVP-----------KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK---EEK 717
Query: 574 LARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
+ ++ E K P+K+ ++P E + ++ +K
Sbjct: 718 VEKKEE-------------KPKDVPEKKKAESPVKEEAVAEVVTITKSVK---------- 754
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 693
V LE+E + E+ K ++ KEKEK G S SD+ +++ DI E
Sbjct: 755 VHLEKETK-----EEGKPLQQEKEKEKAGGEGGSE-EEGSDKGAKGSRKEDIAVNGEVEG 808
Query: 694 ALPSDEDDKDP----NDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPM---- 745
+++ K+ + + LD AD +K + +K+ EK
Sbjct: 809 KEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 868
Query: 746 VEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAE 778
K K +K +E E E+K KK E
Sbjct: 869 ATKYITKSVTVTQKVEEHEETFEEKLVSTKKVE 901
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/357 (23%), Positives = 144/357 (40%), Gaps = 47/357 (13%)
Query: 543 SESEDERPRAVFHEEEQRRPKHRP-----SEADEEELARRREARKQEQANNPFYIKSSPS 597
+E ++E P A EEE+ K P E EEE + E ++E+ KS +
Sbjct: 116 AEEKEEEPEA---EEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172
Query: 598 PQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKE 657
+ + E Q + + G + K EE+ +++ + E
Sbjct: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVE 232
Query: 658 KEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDK 717
K +K K S +P E+ + EE ++ +P ++ P
Sbjct: 233 KPEKAK---SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK------S 283
Query: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK----KPKKKEKKHKE-KERDKEKKKE 772
P+ + K P+ K E +KSP P+ E KSK K ++KE++ KE KE KE+K E
Sbjct: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
Query: 773 -KEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKP 831
KE+K +D+ P A +PV + + T + + E + +++ P
Sbjct: 344 KKEEKPKDV---------PEKKKAESPV-KEEAVAEVVTITKSVKVHLEKETKEEGKPLQ 393
Query: 832 KKKKHRK-------EKEERTKGKKKSKKQP-------PGSEEAAGEPVQNGAPEEEQ 874
++K+ K E+E KG K S+K+ G EE E + G+ EE+
Sbjct: 394 QEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEE 450
Score = 57.8 bits (138), Expect = 6e-08
Identities = 61/287 (21%), Positives = 118/287 (41%), Gaps = 40/287 (13%)
Query: 609 EHIPVVQIDLSV-----------------------------PLKVPGLPMSDQYVKLEEE 639
E + + +L+V P+K + ++ + EEE
Sbjct: 95 EALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE 154
Query: 640 RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQ-QVDIVTEEMPENALPSD 698
++ E+D+ K + +E ++ SS E +++ + + + E E +
Sbjct: 155 EGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEE 214
Query: 699 EDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK 758
+ ++ D ++KP + K P+ K E KSP P VE+K K P K
Sbjct: 215 KSEEVATKEELVADAKVEKP--EKAKSPVPKSPVEEKGKSPVPKSP-VEEKGKSPVPKSP 271
Query: 759 KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDD 818
+EK + K E+K + + P A +PVP + E+AK++A+ + +
Sbjct: 272 V-EEKGKSPVPKSPVEEKGKS-----PVSKSPVEEKAKSPVPKS-PVEEAKSKAEVGKGE 324
Query: 819 AEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
+ +++ + PK++K K++E+ +K K + P EEA E V
Sbjct: 325 QKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEVV 371
Score = 51.6 bits (122), Expect = 4e-06
Identities = 39/170 (22%), Positives = 80/170 (47%), Gaps = 18/170 (10%)
Query: 715 LDKPLADSEKLPIQK---HRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKK 771
+ KP ++ KL +Q E +K ++ M E + ++ KE++++ ++K
Sbjct: 60 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 119
Query: 772 EKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKP 831
E+E +AE+ + +P A AP E +GE+++ EGQ+++++ +
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAP-------------EVKEEEGEKEEEEGQEEEEEEDEG 166
Query: 832 KKKKHRKE--KEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPES 879
K +E E+ +K+ +Q G EA E + A EE+++ +S
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKS 216
Score = 47.4 bits (111), Expect = 8e-05
Identities = 80/398 (20%), Positives = 148/398 (37%), Gaps = 75/398 (18%)
Query: 516 VAPKAQK-KVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEEL 574
++ K QK KV P+ ++ E + +++ EDE+ A EEL
Sbjct: 56 ISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM-----------EEALTAITEEL 104
Query: 575 ARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYV 634
A + K+E A ++ P E V P+K + ++
Sbjct: 105 AVSMKEEKKEAAEEK-------------EEEPEAEEEEVAA--KKSPVKATAPEVKEEEG 149
Query: 635 KLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQ-QVDIVTEEMPEN 693
+ EEE ++ E+D+ K + +E ++ SS E +++ + + + E E
Sbjct: 150 EKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEE 209
Query: 694 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKP 753
++ ++ D ++KP + K P+ K E KSP P VE+K K P
Sbjct: 210 KKVEEKSEEVATKEELVADAKVEKP--EKAKSPVPKSPVEEKGKSPVPKSP-VEEKGKSP 266
Query: 754 KKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQ 813
K P +PVP + E +
Sbjct: 267 VPKS--------------------------------PVEEKGKSPVPK------SPVEEK 288
Query: 814 GEEDDAEGQDQDK-KSPKPKKK-KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 871
G+ ++ ++K KSP PK + K K E KG++K +++ E E V+ +
Sbjct: 289 GKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEK 348
Query: 872 EEQLP----PESSYSLLAENSYVKMTCDIRGSLQEDSQ 905
+ +P ES A V +T ++ L+++++
Sbjct: 349 PKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETK 386
Score = 43.5 bits (101), Expect = 0.001
Identities = 52/240 (21%), Positives = 99/240 (41%), Gaps = 27/240 (11%)
Query: 642 HRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDD 701
HR + + +K K + K K +H + E+I +V+ EM E E+
Sbjct: 50 HRPPITISSKIQKPKVEAPKLKVQHKFV-----EEIIEETKVEDEKSEMEEALTAITEE- 103
Query: 702 KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHK 761
A+ + +K A EK ++ E + K P+ K+ P+ KE++ +
Sbjct: 104 -------LAVSMKEEKKEAAEEK---EEEPEAEEEEVAAKKSPV---KATAPEVKEEEGE 150
Query: 762 EKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEG 821
++E + ++++E+E + D + E E+ +TEA+ E ++AE
Sbjct: 151 KEEEEGQEEEEEEDEGAKSD----QAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 206
Query: 822 QDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPP----GSEEAAGEPVQNGAPEEEQLPP 877
+++ K K ++ ++E K +K K + P EE PV EE+ P
Sbjct: 207 KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSP 266
Score = 37.4 bits (85), Expect = 0.080
Identities = 60/273 (21%), Positives = 104/273 (38%), Gaps = 51/273 (18%)
Query: 514 NPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEE 573
+PV KA+ VP P+ +++S+ E + EEE++ K P EE+
Sbjct: 296 SPVEEKAKSPVP-----------KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPK---EEK 341
Query: 574 LARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
+ ++ E K P+K+ ++P E + ++ +K
Sbjct: 342 VEKKEE-------------KPKDVPEKKKAESPVKEEAVAEVVTITKSVK---------- 378
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 693
V LE+E + E+ K ++ KEKEK G S SD+ +++ DI E
Sbjct: 379 VHLEKETK-----EEGKPLQQEKEKEKAGGEGGSE-EEGSDKGAKGSRKEDIAVNGEVEG 432
Query: 694 ALPSDEDDKDP----NDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPM---- 745
+++ K+ + + LD AD +K + +K+ EK
Sbjct: 433 KEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITSEGGDG 492
Query: 746 VEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAE 778
K K +K +E E E+K KK E
Sbjct: 493 ATKYITKSVTVTQKVEEHEETFEEKLVSTKKVE 525
>gi|33356179 transcription termination factor, RNA polymerase I
[Homo sapiens]
Length = 905
Score = 65.1 bits (157), Expect = 4e-10
Identities = 82/404 (20%), Positives = 150/404 (37%), Gaps = 37/404 (9%)
Query: 531 DLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPF 590
D I+ PL S DE A +++++ ++ E DEE K+ N P
Sbjct: 58 DFQHLISSPLKKSRICDETANATSTLKKRKKRRYSALEVDEEAGVTVVLVDKENINNTPK 117
Query: 591 YIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDK 650
+ + + VV +D+S+ K+P P +D++ L + H+ + K
Sbjct: 118 HFRKD---------------VDVVCVDMSIEQKLPRKPKTDKFQVLAKSHAHKSEALHSK 162
Query: 651 RRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRA 710
R+K K KK +R+ +S ++ D P Q + EE + P E + P ++
Sbjct: 163 VREK---KNKKHQRKAASWESQRARDTLP--QSESHQEESWLSVGPGGEITELPASAHKN 217
Query: 711 LDIDLDKPLADSE----KLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 766
K ++ E +P E ++ P V + P+ HK+K +
Sbjct: 218 KSKKKKKKSSNREYETLAMPEGSQAGREAGTDMQESQPTVGLDDETPQLLGPTHKKKSKK 277
Query: 767 KEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDK 826
K+KKK ++ E L P + + V + + GE
Sbjct: 278 KKKKKSNHQEFEALAM-------PEGSQVGSEVGADMQESRPAVGLHGETAGIPAPAYKN 330
Query: 827 KSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA------GEPVQNGAPEEEQLPPESS 880
KS K KKK + +E E + P GS+ + G G E +S
Sbjct: 331 KSKKKKKKSNHQEFEAVAMPESLESAYPEGSQVGSEVGTVEGSTALKGFKESNSTKKKSK 390
Query: 881 YSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGME 924
L +++ D ++S+ T+ +E + + +G++
Sbjct: 391 KRKLTSVKRARVSGDDFSVPSKNSESTLFDSVEGDGAMMEEGVK 434
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 65.1 bits (157), Expect = 4e-10
Identities = 41/229 (17%), Positives = 105/229 (45%), Gaps = 21/229 (9%)
Query: 638 EERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPS 697
E R R+K EK++ R +++++E++ K + ++ + ++ + + ++ E
Sbjct: 80 ERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDR 139
Query: 698 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 757
+ + D + + +K + ++ R+ E K E++ + + +K+
Sbjct: 140 GRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKER 199
Query: 758 KKHKEKERDKEKKKEKEKKAE-DLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEE 816
++ ++ERD+++K + E++ E D + T D + E Q +
Sbjct: 200 ERQTDRERDRQRKTQTERQRETDREGERET--------------------DRRRERQRDR 239
Query: 817 DDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
D + +D+++ + +KK+ +KE+++ K KKK +K+ + GE +
Sbjct: 240 DRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGEGI 288
Score = 43.1 bits (100), Expect = 0.001
Identities = 32/173 (18%), Positives = 73/173 (42%), Gaps = 26/173 (15%)
Query: 702 KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHK 761
++ + R D D+ EK + +RN + K E + +K K +++ + +
Sbjct: 85 REKTEKERDRDRKRDRERRRKEK---ETNRNRDREKQTEIERDREREKQKGRERERDRGR 141
Query: 762 EKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEG 821
E+ERD++++KE+E++ E D +TE + E D
Sbjct: 142 ERERDRDREKERERQTEK-----------------------DRDGQRETETERERDRERE 178
Query: 822 QDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 874
+ +++++ + + ++ EKE + ++ +Q E E + G E ++
Sbjct: 179 KQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDR 231
Score = 37.7 bits (86), Expect = 0.061
Identities = 22/134 (16%), Positives = 65/134 (48%), Gaps = 22/134 (16%)
Query: 741 KDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVP 800
KD +++ ++ + +EK KE++RD+++ +E+ +K ++ +
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETN------------------R 111
Query: 801 STDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEA 860
+ D + + E E + +G+++++ + +++ +EKE +++++K G E
Sbjct: 112 NRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKER----ERQTEKDRDGQRET 167
Query: 861 AGEPVQNGAPEEEQ 874
E ++ E+++
Sbjct: 168 ETERERDREREKQK 181
Score = 36.2 bits (82), Expect = 0.18
Identities = 24/150 (16%), Positives = 70/150 (46%), Gaps = 8/150 (5%)
Query: 712 DIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKK---HKEKERDKE 768
D D D + +++ + + + + +++ EK++ + + +EK+ +++ER+K+
Sbjct: 71 DADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQ 130
Query: 769 KKKEKEK-----KAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQD 823
K +E+E+ + D D T+ D + E Q E + +D
Sbjct: 131 KGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRD 190
Query: 824 QDKKSPKPKKKKHRKEKEERTKGKKKSKKQ 853
+ + + K ++++ +E++ + K + + +++
Sbjct: 191 RQRDTEKERERQTDRERDRQRKTQTERQRE 220
Score = 33.9 bits (76), Expect = 0.88
Identities = 30/141 (21%), Positives = 63/141 (44%), Gaps = 19/141 (13%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
++E+E ER R ++E+ + R + D E+ R+ R++++ + + + ++R
Sbjct: 166 ETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQ------RKTQTERQR 219
Query: 602 YQDTPG---VEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEK 658
D G + Q D + E +R+ +K E+ K RKK +++
Sbjct: 220 ETDREGERETDRRRERQRDRD----------RGKERDRERDRKEERKKERKKERKKERKE 269
Query: 659 EKKGKRRHSSLPTESDEDIAP 679
+KK ++R + E I+P
Sbjct: 270 KKKEEKRREDKKRKWGEGISP 290
Score = 32.7 bits (73), Expect = 2.0
Identities = 27/137 (19%), Positives = 58/137 (42%), Gaps = 3/137 (2%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEAD---EEELARRREARKQEQANNPFYIKSSPSP 598
D E ER R E E++ K R + + E E R RE +K+ + +
Sbjct: 138 DRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEK 197
Query: 599 QKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEK 658
++ Q + Q + G +D+ + + +R ++ ++++ RK+ ++K
Sbjct: 198 ERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK 257
Query: 659 EKKGKRRHSSLPTESDE 675
E+K +R+ + +E
Sbjct: 258 ERKKERKKERKEKKKEE 274
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 64.7 bits (156), Expect = 5e-10
Identities = 38/119 (31%), Positives = 63/119 (52%), Gaps = 17/119 (14%)
Query: 734 ETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPA 793
ET + EK+ EK+ +K K+KEKK K KE +K K+KE+E+K
Sbjct: 18 ETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRK-------------- 63
Query: 794 PAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKK 852
E E+ + E + EE++ E +++++ + KKKK R+++EE K KK+ +K
Sbjct: 64 ---RKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
Score = 50.4 bits (119), Expect = 9e-06
Identities = 33/141 (23%), Positives = 59/141 (41%), Gaps = 39/141 (27%)
Query: 638 EERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPS 697
EE ++ K+KR++KRKEKEKK K + + E +E+
Sbjct: 20 EEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEE--------------------- 58
Query: 698 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 757
+K K ++ E + E++ EK+ + +KK+
Sbjct: 59 ------------------EKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKK 100
Query: 758 KKHKEKERDKEKKKEKEKKAE 778
KK + KE ++EKKK++ +K +
Sbjct: 101 KKRRRKEEEEEKKKKRRRKTK 121
Score = 47.4 bits (111), Expect = 8e-05
Identities = 35/138 (25%), Positives = 62/138 (44%), Gaps = 32/138 (23%)
Query: 737 KSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAP 796
K +K+ E+ + +++EK+ K KE+ KEK+KEKEKK +
Sbjct: 4 KKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKK------------------ 45
Query: 797 APVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPG 856
T E E K + + E+ K+ K KKKK +E+EE + +++ K++
Sbjct: 46 -----TKETEKRKEKEEEEK---------KRKRKRKKKKEEEEREEEEEEEEEEKEEEEK 91
Query: 857 SEEAAGEPVQNGAPEEEQ 874
E + + +EE+
Sbjct: 92 EEGRRRKKKKKRRRKEEE 109
Score = 45.4 bits (106), Expect = 3e-04
Identities = 41/165 (24%), Positives = 70/165 (42%), Gaps = 55/165 (33%)
Query: 687 TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMV 746
TEE E +E++K+ + + +K +K + ET K EK+
Sbjct: 10 TEETEETEETEEEEEKEGKRKEKRKEKRKEKE---------KKKKTKETEKRKEKEEEEK 60
Query: 747 EKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECE 806
++K K+ KKKE++ +E+E ++E+++EKE
Sbjct: 61 KRKRKRKKKKEEEEREEE-EEEEEEEKE-------------------------------- 87
Query: 807 DAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSK 851
EE+ EG+ + K KKK+ RKE+EE K K++ K
Sbjct: 88 --------EEEKEEGRRR-----KKKKKRRRKEEEEEKKKKRRRK 119
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/126 (23%), Positives = 51/126 (40%), Gaps = 35/126 (27%)
Query: 749 KSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDA 808
K KK KKKE + E+ + E+++EKE K ++
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRKE----------------------------- 31
Query: 809 KTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNG 868
+ + + + KK K +K+ KE+EE+ + +K+ KK+ E E +
Sbjct: 32 ------KRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEE 85
Query: 869 APEEEQ 874
EEE+
Sbjct: 86 KEEEEK 91
Score = 40.4 bits (93), Expect = 0.009
Identities = 21/70 (30%), Positives = 38/70 (54%)
Query: 809 KTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNG 868
+TE E ++ E +++ + K K+K+ RKEKE++ K K+ K++ EE + +
Sbjct: 9 ETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKK 68
Query: 869 APEEEQLPPE 878
EEE+ E
Sbjct: 69 KKEEEEREEE 78
Score = 39.3 bits (90), Expect = 0.021
Identities = 29/127 (22%), Positives = 59/127 (46%), Gaps = 17/127 (13%)
Query: 653 KKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 712
KK+K+K+K+ + + TE +E+ ++ E+ E ++ K R
Sbjct: 1 KKKKKKKKETEETEETEETEEEEEKEGKRK-----EKRKEKRKEKEKKKKTKETEKR--- 52
Query: 713 IDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKE 772
EK +K R + K E++ E++ ++ +K+E++ +E R K+KKK
Sbjct: 53 ---------KEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKR 103
Query: 773 KEKKAED 779
+ K+ E+
Sbjct: 104 RRKEEEE 110
Score = 38.1 bits (87), Expect = 0.047
Identities = 24/113 (21%), Positives = 56/113 (49%)
Query: 556 EEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQ 615
+E + + +E +EE+ +R+E RK+++ K+ + +++ ++ + +
Sbjct: 8 KETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRK 67
Query: 616 IDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSS 668
+ ++ + EE+ R++ +K KRR+K +E+EKK KRR +
Sbjct: 68 KKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRKT 120
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/374 (23%), Positives = 146/374 (39%), Gaps = 64/374 (17%)
Query: 538 EPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQAN---NPFYIKS 594
E LS + +++ E+E ++ P + + + R+ RK E++ NP +++
Sbjct: 866 EKLSARDGHNQKDNTKSKEKES---ENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLET 922
Query: 595 SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKR-RK 653
S ++ ++ GVE + + +P + P+ D+ + E + EKDKR R
Sbjct: 923 S----RKSREPTGVEENKTDSLFV-LPSRDDATPVRDEPMDAESIT-FKSVSEKDKRERD 976
Query: 654 KRKEKEKKGKRRHSSLPTESDEDIA-----PAQQVDIVTEEMPENALPSDEDDKDPNDPY 708
K K K K KR++ E+I P ++VD E P +
Sbjct: 977 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS--------------- 1021
Query: 709 RALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKE 768
+P K K NT++S S +KD + K K K+H+E + KE
Sbjct: 1022 --------EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKE 1073
Query: 769 KKKEKEKKAEDLDFWLSTTPPPAPAP--APAPVPSTDECEDAKTEAQGEEDDAEGQDQD- 825
+K +K+ + L+T A P P+ + E KTE +G + D E
Sbjct: 1074 EKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1133
Query: 826 ---------KKSPKPKKKKHRKEKEERTKGKKKSKKQPP----------GSEEAAGEPVQ 866
K SPK +K + EK +RT K K P G + + E +
Sbjct: 1134 SKLEVTEIVKPSPK-RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENIS 1192
Query: 867 NGAPEEEQLPPESS 880
N E+L SS
Sbjct: 1193 NTKEPSEKLESTSS 1206
Score = 47.8 bits (112), Expect = 6e-05
Identities = 78/340 (22%), Positives = 123/340 (36%), Gaps = 45/340 (13%)
Query: 464 DRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKK 523
D P + D + +E +S + K+ + + KD P + SA +G+ N P+ ++
Sbjct: 1432 DFTPNRDKKTDYDTREYSSSKRRDEKN-ELTRRKDSPSRNKDSA--SGQKNK--PREERD 1486
Query: 524 VPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRR----E 579
+P D ++ + S S D +P + +RP D+ R E
Sbjct: 1487 LPKKGTGD-----SKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLE 1541
Query: 580 AR--KQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLE 637
AR K+ N YI + P Q + G QID S P L S +
Sbjct: 1542 ARNNKESSGNKLLYILNPPETQVEKEQITG-------QIDKSTVKPKPQLSHSSRLSSDL 1594
Query: 638 EERRHRQKLEKDKRRKKR------KEKEKKG---KRRHSSLPTESDEDIAPAQQVDIVTE 688
E D KE+E G K + ++ E + A V +
Sbjct: 1595 TRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGIS 1654
Query: 689 EMPENALPSDEDDKD-----------PNDPYRALDIDLDKPLADSEKLPIQKHRNTETSK 737
++ PS + + A D K EK +KH+ + K
Sbjct: 1655 RNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHK 1714
Query: 738 SPEKDVPMVEK--KSKKPKKKEKKHKEKERDKEKKKEKEK 775
+EK K K KKK KK+K+KE++KEK +K K
Sbjct: 1715 KHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1754
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/295 (23%), Positives = 118/295 (40%), Gaps = 41/295 (13%)
Query: 580 ARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEE 639
++++++ N K SPS K G ++ P + DL P K G +
Sbjct: 1451 SKRRDEKNELTRRKDSPSRNK--DSASGQKNKPREERDL--PKKGTGDSKKSNSSPSRDR 1506
Query: 640 RRHRQKLEKDKRRKKRKEKEK-----KGKRRHSSLPTESDEDIAPAQQVDIVT--EEMPE 692
+ H K D +R + K K + +H L ++++ + + + I+ E E
Sbjct: 1507 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHV-LEARNNKESSGNKLLYILNPPETQVE 1565
Query: 693 NALPSDEDDKDPNDPYRALDIDLDKP-LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 751
+ + DK P KP L+ S +L R T+ + E D + +S
Sbjct: 1566 KEQITGQIDKSTVKP---------KPQLSHSSRLSSDLTRETDEAAF-EPDYNESDSESN 1615
Query: 752 KPKKKEKKHKEKERD-KEKKKEKEKKAEDLDFWLS-------TTPPPAPAPAPAPVPSTD 803
K+E+ +D K+K EK K++ D + + P+ +P+ + PS
Sbjct: 1616 VSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGS 1675
Query: 804 ECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 858
+ + A AE QD KK K +KKKH+K K K K K+ G+E
Sbjct: 1676 QTRSHSSSASS----AESQDSKKKKKKKEKKKHKKHK------KHKKHKKHAGTE 1720
Score = 38.9 bits (89), Expect = 0.027
Identities = 46/219 (21%), Positives = 93/219 (42%), Gaps = 16/219 (7%)
Query: 679 PAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKS 738
PA + V+ + P N + E + +P++ + D+ + E + ++E K+
Sbjct: 1311 PASVIKNVSTK-PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKT 1369
Query: 739 PEKDVPMVEKK-------SKKPKKKEKKHKEKERDKEKK-KEKEKKAEDLDFWLSTTPPP 790
++D ++EK+ S +P+K+ + E+ K + K+A D ST
Sbjct: 1370 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1429
Query: 791 APAPAPAPVPST--DECEDAKTEAQGEEDD----AEGQDQDKKSPKPKKKKHRKEKEERT 844
P T D E + ++ + E+++ + ++K S +K K R+E++
Sbjct: 1430 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK 1489
Query: 845 KGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSL 883
KG SKK S +P + A + + P E + S+
Sbjct: 1490 KGTGDSKKS-NSSPSRDRKPHDHKATYDTKRPNEETKSV 1527
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 64.7 bits (156), Expect = 5e-10
Identities = 88/374 (23%), Positives = 146/374 (39%), Gaps = 64/374 (17%)
Query: 538 EPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQAN---NPFYIKS 594
E LS + +++ E+E ++ P + + + R+ RK E++ NP +++
Sbjct: 900 EKLSARDGHNQKDNTKSKEKES---ENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLET 956
Query: 595 SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKR-RK 653
S ++ ++ GVE + + +P + P+ D+ + E + EKDKR R
Sbjct: 957 S----RKSREPTGVEENKTDSLFV-LPSRDDATPVRDEPMDAESIT-FKSVSEKDKRERD 1010
Query: 654 KRKEKEKKGKRRHSSLPTESDEDIA-----PAQQVDIVTEEMPENALPSDEDDKDPNDPY 708
K K K K KR++ E+I P ++VD E P +
Sbjct: 1011 KPKAKGDKTKRKNDGSAVSKKENIVKPAKGPQEKVDGERERSPRS--------------- 1055
Query: 709 RALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKE 768
+P K K NT++S S +KD + K K K+H+E + KE
Sbjct: 1056 --------EPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHSKSAKEHQETKPVKE 1107
Query: 769 KKKEKEKKAEDLDFWLSTTPPPAPAP--APAPVPSTDECEDAKTEAQGEEDDAEGQDQD- 825
+K +K+ + L+T A P P+ + E KTE +G + D E
Sbjct: 1108 EKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEEKGVDKDFESSSMKI 1167
Query: 826 ---------KKSPKPKKKKHRKEKEERTKGKKKSKKQPP----------GSEEAAGEPVQ 866
K SPK +K + EK +RT K K P G + + E +
Sbjct: 1168 SKLEVTEIVKPSPK-RKMEPDTEKMDRTPEKDKISLSAPAKKIKLNRETGKKIGSTENIS 1226
Query: 867 NGAPEEEQLPPESS 880
N E+L SS
Sbjct: 1227 NTKEPSEKLESTSS 1240
Score = 47.8 bits (112), Expect = 6e-05
Identities = 78/340 (22%), Positives = 123/340 (36%), Gaps = 45/340 (13%)
Query: 464 DRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKK 523
D P + D + +E +S + K+ + + KD P + SA +G+ N P+ ++
Sbjct: 1466 DFTPNRDKKTDYDTREYSSSKRRDEKN-ELTRRKDSPSRNKDSA--SGQKNK--PREERD 1520
Query: 524 VPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRR----E 579
+P D ++ + S S D +P + +RP D+ R E
Sbjct: 1521 LPKKGTGD-----SKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREKHVLE 1575
Query: 580 AR--KQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLE 637
AR K+ N YI + P Q + G QID S P L S +
Sbjct: 1576 ARNNKESSGNKLLYILNPPETQVEKEQITG-------QIDKSTVKPKPQLSHSSRLSSDL 1628
Query: 638 EERRHRQKLEKDKRRKKR------KEKEKKG---KRRHSSLPTESDEDIAPAQQVDIVTE 688
E D KE+E G K + ++ E + A V +
Sbjct: 1629 TRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGIS 1688
Query: 689 EMPENALPSDEDDKD-----------PNDPYRALDIDLDKPLADSEKLPIQKHRNTETSK 737
++ PS + + A D K EK +KH+ + K
Sbjct: 1689 RNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKKKKKEKKKHKKHKKHKKHK 1748
Query: 738 SPEKDVPMVEK--KSKKPKKKEKKHKEKERDKEKKKEKEK 775
+EK K K KKK KK+K+KE++KEK +K K
Sbjct: 1749 KHAGTEVELEKSQKHKHKKKKSKKNKDKEKEKEKDDQKVK 1788
Score = 42.7 bits (99), Expect = 0.002
Identities = 69/295 (23%), Positives = 118/295 (40%), Gaps = 41/295 (13%)
Query: 580 ARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEE 639
++++++ N K SPS K G ++ P + DL P K G +
Sbjct: 1485 SKRRDEKNELTRRKDSPSRNK--DSASGQKNKPREERDL--PKKGTGDSKKSNSSPSRDR 1540
Query: 640 RRHRQKLEKDKRRKKRKEKEK-----KGKRRHSSLPTESDEDIAPAQQVDIVT--EEMPE 692
+ H K D +R + K K + +H L ++++ + + + I+ E E
Sbjct: 1541 KPHDHKATYDTKRPNEETKSVDKNPCKDREKHV-LEARNNKESSGNKLLYILNPPETQVE 1599
Query: 693 NALPSDEDDKDPNDPYRALDIDLDKP-LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 751
+ + DK P KP L+ S +L R T+ + E D + +S
Sbjct: 1600 KEQITGQIDKSTVKP---------KPQLSHSSRLSSDLTRETDEAAF-EPDYNESDSESN 1649
Query: 752 KPKKKEKKHKEKERD-KEKKKEKEKKAEDLDFWLS-------TTPPPAPAPAPAPVPSTD 803
K+E+ +D K+K EK K++ D + + P+ +P+ + PS
Sbjct: 1650 VSVKEEESSGNISKDLKDKIVEKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGS 1709
Query: 804 ECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 858
+ + A AE QD KK K +KKKH+K K K K K+ G+E
Sbjct: 1710 QTRSHSSSASS----AESQDSKKKKKKKEKKKHKKHK------KHKKHKKHAGTE 1754
Score = 38.9 bits (89), Expect = 0.027
Identities = 46/219 (21%), Positives = 93/219 (42%), Gaps = 16/219 (7%)
Query: 679 PAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKS 738
PA + V+ + P N + E + +P++ + D+ + E + ++E K+
Sbjct: 1345 PASVIKNVSTK-PSNIVKYPEKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKT 1403
Query: 739 PEKDVPMVEKK-------SKKPKKKEKKHKEKERDKEKK-KEKEKKAEDLDFWLSTTPPP 790
++D ++EK+ S +P+K+ + E+ K + K+A D ST
Sbjct: 1404 KDRDYSVLEKENPEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTRASS 1463
Query: 791 APAPAPAPVPST--DECEDAKTEAQGEEDD----AEGQDQDKKSPKPKKKKHRKEKEERT 844
P T D E + ++ + E+++ + ++K S +K K R+E++
Sbjct: 1464 NKDFTPNRDKKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDSASGQKNKPREERDLPK 1523
Query: 845 KGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSL 883
KG SKK S +P + A + + P E + S+
Sbjct: 1524 KGTGDSKKS-NSSPSRDRKPHDHKATYDTKRPNEETKSV 1561
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/357 (21%), Positives = 146/357 (40%), Gaps = 42/357 (11%)
Query: 537 NEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSP 596
N+ SE +++ + + +E R S + +E + R+ +K+ Q N P P
Sbjct: 158 NKKWDGSEEDEDNSKKI--KERSRINSSGESGDESDEFLQSRKGQKKNQKNKP-----GP 210
Query: 597 SPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKR-RKKR 655
+ + +D I V + + ++ KL + + +++LE K+ + K+
Sbjct: 211 NIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRK-LKEKEELETGKKDQSKQ 269
Query: 656 KEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDL 715
KE ++K + D + PA + E P A +E DK D +
Sbjct: 270 KESQRKFEEETVKSKVTVDTGVIPASEEKA---ETPTAAEDDNEGDKKKKDKKKKKGEKE 326
Query: 716 DKPL------------ADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK 763
+K A E L K + E+ + +E+ K K++E+ +EK
Sbjct: 327 EKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEK 386
Query: 764 -ERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQ 822
ER K+K+KE++++ + L+ + A A A A + A+G
Sbjct: 387 RERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLL---------------QAQGV 431
Query: 823 DQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEE--AAGEPVQNGAPEEEQLPP 877
+ K PKK+ ++K+ + ++ K+ S E AA E ++ G PE+E+ PP
Sbjct: 432 EVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP 488
Score = 59.7 bits (143), Expect = 1e-08
Identities = 78/369 (21%), Positives = 159/369 (43%), Gaps = 69/369 (18%)
Query: 516 VAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELA 575
V P +++K P + D NE D + +D++ + EE+++ K PS+A + +
Sbjct: 291 VIPASEEKAETPTAAEDD---NE--GDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQ 345
Query: 576 RRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVK 635
K+E+ QKR ++ E I ++ +L K + +
Sbjct: 346 EALAKLKEEEER-----------QKREEE----ERIKRLE-ELEAKRK--------EEER 381
Query: 636 LEEERRHRQKLEKDKRRKKRKEKEKK---GKRRHSSLPTESDEDIAPAQQVDIVTEEMPE 692
LE+E+R R+K +K+K RK+R +KE K +R + E+ + AQ V++ +++
Sbjct: 382 LEQEKRERKK-QKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLP 440
Query: 693 NALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKK 752
P ED K +K+P Q+ + E S+S E + +
Sbjct: 441 KKRPIYEDKK-------------------RKKIP-QQLESKEVSESMELCAAVEVMEQGV 480
Query: 753 PKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEA 812
P+K+E E ++E++ + LD W A A T++ E K
Sbjct: 481 PEKEETPPPV-----EPEEEEDTEDAGLDDW----------EAMASDEETEKVEGNKVHI 525
Query: 813 QGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEE 872
+ +E+ E ++++++ + ++ + +E+E ++G + ++ S+E + P +
Sbjct: 526 EVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSK 585
Query: 873 EQLPPESSY 881
E + +S Y
Sbjct: 586 E-MSSDSEY 593
Score = 55.5 bits (132), Expect = 3e-07
Identities = 91/390 (23%), Positives = 150/390 (38%), Gaps = 58/390 (14%)
Query: 498 DVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEE 557
D AE A A E P K +KK + + +D + E
Sbjct: 20 DALAAEIEGAGAAKEQEPQKSKGKKK-----------------KEKKKQDFDEDDILKEL 62
Query: 558 EQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQID 617
E+ + + +AD E +A + +E+ + K +K+ D E + D
Sbjct: 63 EELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELE----D 118
Query: 618 LSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDI 677
K P + Y +++ + +K KK K K +K ++ +E DED
Sbjct: 119 KDSKSKKTAKPKVEMYSGSDDDD------DFNKLPKKAKGKAQKSNKKWDG--SEEDEDN 170
Query: 678 APAQQVDIVTEEMPENALPSDE--------DDKDPNDPYRALDI-DLDKPLADSEKLPIQ 728
+ + E+ SDE N P ++ + D + K Q
Sbjct: 171 SKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQ 230
Query: 729 KHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEK-ERDKEKKKEKEKKAEDLDFWLSTT 787
K + + ++D E+K+K K KEK+ E ++D+ K+KE ++K E+ T
Sbjct: 231 KKAEKKERERKKRD----EEKAKLRKLKEKEELETGKKDQSKQKESQRKFEE------ET 280
Query: 788 PPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGK 847
+P+++E + T A EDD EG DKK KKKK KE++E+ K K
Sbjct: 281 VKSKVTVDTGVIPASEEKAETPTAA---EDDNEG---DKKKKDKKKKKGEKEEKEKEKKK 334
Query: 848 KKSKKQPPGSEEAAG---EPVQNGAPEEEQ 874
SK +EA E + EEE+
Sbjct: 335 GPSKATVKAMQEALAKLKEEEERQKREEEE 364
Score = 49.3 bits (116), Expect = 2e-05
Identities = 64/270 (23%), Positives = 112/270 (41%), Gaps = 34/270 (12%)
Query: 637 EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIV-TEEMPENAL 695
+E+ + K +K K +KK+ E + L E+ A + V + TE E
Sbjct: 33 KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92
Query: 696 PSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSK---------SPEKDVPMV 746
D+ K ++ D + DSE+L + ++ +T+K + D +
Sbjct: 93 SKDKKKKGQKGKKQSFDDN------DSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKL 146
Query: 747 EKKSK-KPKKKEKKHKEKERDKEKKKEKEKKA---------EDLDFWLSTTPPPAPAPAP 796
KK+K K +K KK E D++ K+ ++++ ++ D +L +
Sbjct: 147 PKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKN 206
Query: 797 APVP---STDECEDA----KTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKK 849
P P S +E +DA KT AQ + + E + + + K K +K KEKEE GKK
Sbjct: 207 KPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRK-LKEKEELETGKKD 265
Query: 850 SKKQPPGSEEAAGEPVQNGAPEEEQLPPES 879
KQ + E V++ + + P S
Sbjct: 266 QSKQKESQRKFEEETVKSKVTVDTGVIPAS 295
Score = 48.9 bits (115), Expect = 3e-05
Identities = 60/328 (18%), Positives = 135/328 (41%), Gaps = 49/328 (14%)
Query: 565 RPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKV 624
+P+E +EEE + + +K ++ + + + P V++
Sbjct: 82 KPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEM-------Y 134
Query: 625 PGLPMSDQYVKLEEE-----RRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPT--ESDEDI 677
G D + KL ++ ++ +K + + + +K K+ R +SS + ESDE +
Sbjct: 135 SGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFL 194
Query: 678 APAQQVDIVTEEMPENALPSDEDDKDPNDPYRAL------DIDLDKPLADSEKLPIQKHR 731
+ + P + S +D D + + + + ++ D EK ++K +
Sbjct: 195 QSRKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK 254
Query: 732 NTETSKSPEKD--------------------------VPMVEKKSKKPKKKEKKHKEKER 765
E ++ +KD +P E+K++ P E + E
Sbjct: 255 EKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAED---DNEG 311
Query: 766 DKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQD 825
DK+KK +K+KK E + P+ A A + + ++ + + EE++ + ++
Sbjct: 312 DKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEE 371
Query: 826 KKSPKPKKKKHRKEKEERTKGKKKSKKQ 853
++ + ++++ +EK ER K K+K +K+
Sbjct: 372 LEAKRKEEERLEQEKRERKKQKEKERKE 399
Score = 47.4 bits (111), Expect = 8e-05
Identities = 64/321 (19%), Positives = 133/321 (41%), Gaps = 33/321 (10%)
Query: 536 INEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELAR-RREARKQEQANNPFYIKS 594
+ E L+ + E+ER + E +R + +EE L + +RE +KQ++ +K
Sbjct: 344 MQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKK 403
Query: 595 SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKK 654
+ Q +++ + ++VP KD KK
Sbjct: 404 EGKLLTKSQREARARAEATLKLLQAQGVEVP---------------------SKDSLPKK 442
Query: 655 RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDID 714
R E K KR+ ES E ++ + ++ E M E +P E+ P +P D +
Sbjct: 443 RPIYEDK-KRKKIPQQLESKE-VSESMELCAAVEVM-EQGVPEKEETPPPVEPEEEEDTE 499
Query: 715 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKE 774
D L D E + + E ++ E + +E K + P+++E++ +E+E D+E ++E+E
Sbjct: 500 -DAGLDDWEAM-----ASDEETEKVEGNKVHIEVK-ENPEEEEEEEEEEEEDEESEEEEE 552
Query: 775 KKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK 834
++ E + + + D+ + + E D + + +++++ K+
Sbjct: 553 EEGES-EGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKR 611
Query: 835 KHRKEKEERTKGKKKSKKQPP 855
+ K + E +K K + P
Sbjct: 612 RIEKRRLEHSKNVNTEKLRAP 632
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/229 (20%), Positives = 104/229 (45%), Gaps = 26/229 (11%)
Query: 631 DQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEM 690
D + KLEEE+ ++K E+ + K+R+E+E++ +R E + + ++ + E
Sbjct: 286 DTHKKLEEEKGKKEK-ERQEIEKERRERERERERERERREREREREREREREKEKERERE 344
Query: 691 PENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKS 750
E D + D R D D D+ + + R + E++ ++
Sbjct: 345 RERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERE 404
Query: 751 KKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKT 810
++ +++ ++ +E+ER++E+++EK+KK + + D E K
Sbjct: 405 REREREREREREREREREREREKDKKRDREE------------------DEEDAYERRKL 446
Query: 811 EAQGEEDDAEGQD-------QDKKSPKPKKKKHRKEKEERTKGKKKSKK 852
E + E +A Q+ +++K + +K+ +E+E R + K++K+
Sbjct: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKR 495
Score = 61.2 bits (147), Expect = 5e-09
Identities = 70/351 (19%), Positives = 138/351 (39%), Gaps = 35/351 (9%)
Query: 544 ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQ 603
E E ER R E+E+ R + R + D + R R +E+ + +SS + R +
Sbjct: 324 EREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSR 383
Query: 604 DTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGK 663
D+ + E ER ++ E+++ R++ +E+E++ +
Sbjct: 384 SRE---------------------KSRDRERERERERERERERERERERERERERERERE 422
Query: 664 R-RHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADS 722
R R + +ED A + + ++ E E K+ R + +K
Sbjct: 423 REREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAERE 482
Query: 723 EKLPIQKHRNTETSKS------PEKDVPMVEKKSKKPKKKEKKHKEKERD-KEKKKEKEK 775
E+ + + + K ++D P + S K+ + KE E D +++K+EKE+
Sbjct: 483 EERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEE 542
Query: 776 KAEDLDFWLSTTPPPAPAPAPAPVPSTDECE--DAKTEAQGEEDDAEGQDQDKKSPKPKK 833
E L+ P A + K E + EE++ E Q++++K +P +
Sbjct: 543 LEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPME 602
Query: 834 KKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ----LPPESS 880
++ E++ K + P A+G N +E +P E+S
Sbjct: 603 EEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENS 653
Score = 47.8 bits (112), Expect = 6e-05
Identities = 57/297 (19%), Positives = 116/297 (39%), Gaps = 31/297 (10%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
+ E E ER R E E+ R + R E + E + + R +E+ Y + + R
Sbjct: 392 EREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLR 451
Query: 602 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRK--KRKEKE 659
++ E + +I ER+ ++ EK+ R+ +R+E
Sbjct: 452 EKEAAYQERLKNWEI---------------------RERKKTREYEKEAEREEERRREMA 490
Query: 660 KKGKRRHSSLPT-ESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKP 718
K+ KR L + D D + + + + + + D++D L+ +
Sbjct: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRL 550
Query: 719 LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAE 778
LA+ P + + E + + ++ + +++EK+ KE++R E+ E+E++ E
Sbjct: 551 LAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKR--EEPMEEEEEPE 608
Query: 779 DLDFWLSTTPPPAPAPAPA-----PVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPK 830
T P + AP+ + P+T E E+ + Q ++ PK
Sbjct: 609 QKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPK 665
Score = 42.4 bits (98), Expect = 0.002
Identities = 46/223 (20%), Positives = 91/223 (40%), Gaps = 37/223 (16%)
Query: 652 RKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRAL 711
RKK+KEK++ RR +AP ++T+E NA+ +ED +D
Sbjct: 234 RKKKKEKKEDIFRRFP---------VAPLIPYPLITKE-DINAIEMEEDKRD-------- 275
Query: 712 DIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKK 771
L E I K R+T + E+K KK K++++ KE+ R++E+++
Sbjct: 276 -------LISRE---ISKFRDTHKK--------LEEEKGKKEKERQEIEKER-RERERER 316
Query: 772 EKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKP 831
E+E++ + + D D E + D +D+D++
Sbjct: 317 ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSD 376
Query: 832 KKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 874
+ K + +E+ +++ +++ E E + E E+
Sbjct: 377 RNKDRSRSREKSRDRERERERERERERERERERERERERERER 419
Score = 40.8 bits (94), Expect = 0.007
Identities = 49/239 (20%), Positives = 91/239 (38%), Gaps = 24/239 (10%)
Query: 536 INEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSS 595
+ E L D + + + P+ Q+R + R E + +E R+RE + E+ +
Sbjct: 496 LKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH 555
Query: 596 PSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKR 655
P P Q + + P Q + EEE +Q EK+++R++
Sbjct: 556 PDPDAELQ-------------RMEQEAERRRQPQIKQEPESEEEEEEKQ--EKEEKREEP 600
Query: 656 KEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDL 715
E+E++ +++ PT AP+ NA P+ D+ P +
Sbjct: 601 MEEEEEPEQKPCLKPTLRPISSAPS------VSSASGNATPNTPGDESPCGIIIPHENSP 654
Query: 716 DKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE-KKHKEKERDKEKKKEK 773
D+ + + I S SP + P K+ K P K ++++ D +K K
Sbjct: 655 DQQQPEEHRPKIGLSLKLGASNSPGQ--PNSVKRKKLPVDSVFNKFEDEDSDDVPRKRK 711
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 37/244 (15%)
Query: 637 EEERRHRQKLEKDKRRKKRKEKEK-KGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENAL 695
E+E+ + ++DK R+K +EK+K K + R E D D ++ D E + +
Sbjct: 406 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 465
Query: 696 PSDED---DKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKK 752
DE DK P R+ + + E+ ++ R+ +S+SP + K S+
Sbjct: 466 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRER---RRRRSRSSSRSPRTSKTIKRKSSRS 522
Query: 753 PKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEA 812
P + + K+K+R+KE+ E++ + T
Sbjct: 523 PSPRSRNKKDKKREKERDHISERRE----------------------------RERSTSM 554
Query: 813 QGEEDDAEGQDQ-DKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 871
+ +D +G+++ +K S K+K+H KE + + K+ K P +EE + N
Sbjct: 555 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS-SVSKEVDDKDAPRTEENKIQHNGNCQLN 613
Query: 872 EEQL 875
EE L
Sbjct: 614 EENL 617
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/281 (20%), Positives = 106/281 (37%), Gaps = 33/281 (11%)
Query: 639 ERRHRQKLEKDKRRKKRKEKEKKGKRRHS-SLPTESDEDIAPAQQVDIVTEEMPENALPS 697
++ R+ K+R K +E+ K R HS ++ E I ++V E
Sbjct: 345 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 404
Query: 698 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 757
E +K+ R + D DK + +K R E K EKD ++K + +K+
Sbjct: 405 REKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 459
Query: 758 KKHKEKERDKEKKKEKEKKAEDLDFWLS-----------------------TTPPPAPAP 794
+K + KE D+++KK+K+ + + S T+
Sbjct: 460 EKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 519
Query: 795 APAPVPSTDECEDAKTEAQ----GEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKS 850
+ +P P + +D K E + E + E +KS + K + EK + +K+
Sbjct: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
Query: 851 KKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVK 891
K+P S + EE ++ + L EN K
Sbjct: 580 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 620
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/167 (25%), Positives = 73/167 (43%), Gaps = 38/167 (22%)
Query: 729 KHRNTETSKSPEKDVPMVEKKSK---------KPKKKEKKHKEKERDKEKKKEKEKKAED 779
+ ++ SKSP K ++ K K K +K KEKER KEK +EKE++ E
Sbjct: 344 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE- 402
Query: 780 LDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKE 839
E E K + ++ D E +++D++ K K ++ +E
Sbjct: 403 -----------------------KEREKEKERGKNKDRDKE-REKDREKDKEKDRERERE 438
Query: 840 KE-ERTKGKKKSKKQPPGSE---EAAGEPVQNGAPEEEQLPPESSYS 882
KE E+ + K+K K+Q E + + E + +++ P SY+
Sbjct: 439 KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN 485
Score = 34.3 bits (77), Expect = 0.67
Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 25/193 (12%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
D E + ER R HE++ R K + E D+E+ R + R +E K S +P +
Sbjct: 428 DKEKDREREREKEHEKD--RDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPPRS 483
Query: 602 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEER--RHRQKLEKDKRRKK----- 654
Y + + P + + +K + R R + +KDK+R+K
Sbjct: 484 Y-NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHI 542
Query: 655 --RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 712
R+E+E+ R SS + E + E +L E +K+P+
Sbjct: 543 SERRERERSTSMRKSSNDRDGKEKL-----------EKNSTSLKEKEHNKEPDSSVSKEV 591
Query: 713 IDLDKPLADSEKL 725
D D P + K+
Sbjct: 592 DDKDAPRTEENKI 604
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 63.2 bits (152), Expect = 1e-09
Identities = 55/244 (22%), Positives = 102/244 (41%), Gaps = 37/244 (15%)
Query: 637 EEERRHRQKLEKDKRRKKRKEKEK-KGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENAL 695
E+E+ + ++DK R+K +EK+K K + R E D D ++ D E + +
Sbjct: 290 EKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSK 349
Query: 696 PSDED---DKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKK 752
DE DK P R+ + + E+ ++ R+ +S+SP + K S+
Sbjct: 350 EIDEKRKKDKKSRTPPRSYNASRRSRSSSRER---RRRRSRSSSRSPRTSKTIKRKSSRS 406
Query: 753 PKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEA 812
P + + K+K+R+KE+ E++ + T
Sbjct: 407 PSPRSRNKKDKKREKERDHISERRE----------------------------RERSTSM 438
Query: 813 QGEEDDAEGQDQ-DKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPE 871
+ +D +G+++ +K S K+K+H KE + + K+ K P +EE + N
Sbjct: 439 RKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS-SVSKEVDDKDAPRTEENKIQHNGNCQLN 497
Query: 872 EEQL 875
EE L
Sbjct: 498 EENL 501
Score = 58.2 bits (139), Expect = 4e-08
Identities = 59/281 (20%), Positives = 106/281 (37%), Gaps = 33/281 (11%)
Query: 639 ERRHRQKLEKDKRRKKRKEKEKKGKRRHS-SLPTESDEDIAPAQQVDIVTEEMPENALPS 697
++ R+ K+R K +E+ K R HS ++ E I ++V E
Sbjct: 229 QKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKE 288
Query: 698 DEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKE 757
E +K+ R + D DK + +K R E K EKD ++K + +K+
Sbjct: 289 REKEKE-----RGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKER 343
Query: 758 KKHKEKERDKEKKKEKEKKAEDLDFWLS-----------------------TTPPPAPAP 794
+K + KE D+++KK+K+ + + S T+
Sbjct: 344 EKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKS 403
Query: 795 APAPVPSTDECEDAKTEAQ----GEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKS 850
+ +P P + +D K E + E + E +KS + K + EK + +K+
Sbjct: 404 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 463
Query: 851 KKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVK 891
K+P S + EE ++ + L EN K
Sbjct: 464 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 504
Score = 46.2 bits (108), Expect = 2e-04
Identities = 42/167 (25%), Positives = 73/167 (43%), Gaps = 38/167 (22%)
Query: 729 KHRNTETSKSPEKDVPMVEKKSK---------KPKKKEKKHKEKERDKEKKKEKEKKAED 779
+ ++ SKSP K ++ K K K +K KEKER KEK +EKE++ E
Sbjct: 228 RQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERERE- 286
Query: 780 LDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKE 839
E E K + ++ D E +++D++ K K ++ +E
Sbjct: 287 -----------------------KEREKEKERGKNKDRDKE-REKDREKDKEKDRERERE 322
Query: 840 KE-ERTKGKKKSKKQPPGSE---EAAGEPVQNGAPEEEQLPPESSYS 882
KE E+ + K+K K+Q E + + E + +++ P SY+
Sbjct: 323 KEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN 369
Score = 34.3 bits (77), Expect = 0.67
Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 25/193 (12%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
D E + ER R HE++ R K + E D+E+ R + R +E K S +P +
Sbjct: 312 DKEKDREREREKEHEKD--RDKEKEKEQDKEK--EREKDRSKEIDEKRKKDKKSRTPPRS 367
Query: 602 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEER--RHRQKLEKDKRRKK----- 654
Y + + P + + +K + R R + +KDK+R+K
Sbjct: 368 Y-NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHI 426
Query: 655 --RKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 712
R+E+E+ R SS + E + E +L E +K+P+
Sbjct: 427 SERRERERSTSMRKSSNDRDGKEKL-----------EKNSTSLKEKEHNKEPDSSVSKEV 475
Query: 713 IDLDKPLADSEKL 725
D D P + K+
Sbjct: 476 DDKDAPRTEENKI 488
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/225 (19%), Positives = 101/225 (44%), Gaps = 38/225 (16%)
Query: 628 PMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVT 687
P + + + ++ERR R+K ++++ +++++E+ KK K++ + + ++
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87
Query: 688 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE 747
E + ++ K R + +K +K R E + E+
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGR--------RERKKKKERKERERENKQRRERK----R 135
Query: 748 KKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECED 807
KK +K K+++++ +EKER K ++K K++K E+ +
Sbjct: 136 KKRRKKKRRKERKREKERGKRERKRKKRKKEE--------------------------RE 169
Query: 808 AKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKK 852
K E +E E + ++++ K ++KK R++K+ER K +K ++
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214
Score = 50.8 bits (120), Expect = 7e-06
Identities = 40/153 (26%), Positives = 71/153 (46%), Gaps = 8/153 (5%)
Query: 715 LDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKE---KKK 771
+ KP E ++ R E K + E+K ++ KK++KK K++ER KE K+K
Sbjct: 25 ISKPCTQRESERKKERREREKRKREREK----ERKRERGKKEKKKRKKRERGKERERKRK 80
Query: 772 EKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQD-KKSPK 830
E+EK+ ++ E + K + E ++ + +++ KK K
Sbjct: 81 EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRK 140
Query: 831 PKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGE 863
K++K RK ++ER K ++K KK+ E E
Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRE 173
Score = 45.1 bits (105), Expect = 4e-04
Identities = 40/239 (16%), Positives = 93/239 (38%), Gaps = 45/239 (18%)
Query: 536 INEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSS 595
I++P + ESE ++ R + ++ R K R E ++E +R++ + ++ +
Sbjct: 25 ISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREK 84
Query: 596 PSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKR 655
++R E+ERR R+K +K + RK+R
Sbjct: 85 QRKERR-----------------------------------EKERRKRKKEKKKRERKQR 109
Query: 656 KEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDL 715
+E+K K+ E+ + ++ + E + ++ R +
Sbjct: 110 GRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE--- 166
Query: 716 DKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKE 774
E+ ++ E K E+ KK +K ++++KK ++K+R +++ + +
Sbjct: 167 -------EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 32.0 bits (71), Expect = 3.3
Identities = 20/75 (26%), Positives = 37/75 (49%), Gaps = 4/75 (5%)
Query: 804 ECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHR----KEKEERTKGKKKSKKQPPGSEE 859
E E K E + E G+ + KK K ++ K R KE+E++ K +++ +++ E+
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEK 101
Query: 860 AAGEPVQNGAPEEEQ 874
E Q G E ++
Sbjct: 102 KKRERKQRGRRERKK 116
Score = 31.6 bits (70), Expect = 4.4
Identities = 28/139 (20%), Positives = 57/139 (41%), Gaps = 1/139 (0%)
Query: 546 EDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDT 605
E E+ R E+E+R+ K + + ++ RR +K+E+ K +++ +
Sbjct: 81 EREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRK 140
Query: 606 PGVEHIPVVQIDLSV-PLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKR 664
+ + K ++ K E R+ R+K + K R++RK++ KK +R
Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200
Query: 665 RHSSLPTESDEDIAPAQQV 683
+ + D QV
Sbjct: 201 KKKERKKDRKTDRQTDSQV 219
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 62.4 bits (150), Expect = 2e-09
Identities = 73/405 (18%), Positives = 168/405 (41%), Gaps = 39/405 (9%)
Query: 535 WINEPLSDSESEDERPRAVFH-----EEEQRRPKHRPSEAD--EEELARRREARKQEQAN 587
W E + + ++E R F EE+ R + R S E+ R+ A +++Q
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 588 NPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLE 647
F + Q+R Q + + ++ + + + + ++ L+E++ R+ E
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 648 KDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDP 707
+ + +K R + E++ KRR +L + ++ ++ EE E L +E +K
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE--EEELQREEREKRRRQE 925
Query: 708 YRALDIDLDKPLADSEKL---PIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKE 764
+ ++ + E+L +K R E + KD + +K+ + ++ +K + +E
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQE 985
Query: 765 RDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECED----------------- 807
R+K+ ++E+E + E+ DE +
Sbjct: 986 REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQE 1045
Query: 808 ------AKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAA 861
+ E Q EE+ G++++ + + ++++RKE+E + + ++ +++P E+
Sbjct: 1046 RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP---EKRR 1102
Query: 862 GEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQV 906
+ + EEE+L E LL E + ++ +E+ +V
Sbjct: 1103 RQERERQCREEEELQQEEE-QLLREEREKRRRQELERQYREEEEV 1146
Score = 58.9 bits (141), Expect = 3e-08
Identities = 71/361 (19%), Positives = 154/361 (42%), Gaps = 62/361 (17%)
Query: 528 EGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQAN 587
E L+ + + L E E+ER + + EEQ + + +++E +R R++E+
Sbjct: 608 ERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEER 667
Query: 588 NPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQ--- 644
+K ++R Q+ E Q + ++P +LE E RQ
Sbjct: 668 LEQRLKREHEEERREQELAEEEQ---EQARERIKSRIPKWQW-----QLESEADARQSKV 719
Query: 645 --KLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDK 702
+ K + +++R+E+E+K +RR S L + +E QQ + E+ + ++K
Sbjct: 720 YSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQRRDFTWQWQAEEK 776
Query: 703 DPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKE 762
R + PL + + ++ R E + ++ +P E++ K+ ++++++ +E
Sbjct: 777 SERGRQR---LSARPPLREQRE---RQLRAEERQQREQRFLP--EEEEKEQRRRQRRERE 828
Query: 763 KE---RDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDA 819
KE ++E++ ++ ++A+ L EE+D
Sbjct: 829 KELQFLEEEEQLQRRERAQQLQ---------------------------------EEEDG 855
Query: 820 EGQDQDKKSPKPKKK--KHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPP 877
+DQ+++ + +++ K R + EE K ++ + P +E + Q EEE+L
Sbjct: 856 LQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915
Query: 878 E 878
E
Sbjct: 916 E 916
Score = 56.6 bits (135), Expect = 1e-07
Identities = 73/370 (19%), Positives = 152/370 (41%), Gaps = 46/370 (12%)
Query: 538 EPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPS 597
+ L SE ++ER + E+Q R + R +EEE +R R+ E+ +
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 598 PQKRYQDTPGVEHIPVVQIDL------------SVPLKVPGLPMSDQYVK---------- 635
Q R + IP Q L S P K G + +
Sbjct: 691 EQARERIK---SRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQ 747
Query: 636 -LEEERRHRQKLEKDKRRK-----KRKEKEKKGKRRHSSLP--TESDEDIAPAQQVDIVT 687
EEER HRQ+ E+++RR + +EK ++G++R S+ P E E A++
Sbjct: 748 WQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE----R 803
Query: 688 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE 747
++ + LP +E+ + R + +L + L + E+L + E ++ +++ ++
Sbjct: 804 QQREQRFLPEEEEKEQRRRQRREREKEL-QFLEEEEQL-----QRRERAQQLQEEEDGLQ 857
Query: 748 KKSKKPKKKEKKHKEKER---DKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDE 804
+ ++ + +E++ +K R ++E+K+ + +E
Sbjct: 858 EDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREE 917
Query: 805 CEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEP 864
E + + Q + E Q Q ++ ++++ ++ ++ER + +K KK E+ GE
Sbjct: 918 REKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 865 VQNGAPEEEQ 874
+ +E +
Sbjct: 978 PEKRRRQERE 987
Score = 55.1 bits (131), Expect = 4e-07
Identities = 74/395 (18%), Positives = 159/395 (40%), Gaps = 64/395 (16%)
Query: 544 ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQ 603
E ++ R + + E+E+RR + + +EE L +R + +Q + ++R Q
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE---------ERREQ 548
Query: 604 DTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHR-------------------Q 644
E + Q LK DQ +K EEERR + +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 645 KLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDP 704
+LE+++RR++R ++E+ + R L +++ QQ+ +E E L +E+++
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERL 668
Query: 705 NDPYRALDID--LDKPLADSEKLPIQKHRNTETSK-----SPEKDVPMVEKKSKKPKKKE 757
+ + ++ LA+ E+ ++ + K E D + S+ K++
Sbjct: 669 EQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEG 728
Query: 758 KKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEED 817
++ ++++ +K +++E E + ++ + A ++ D + Q EE
Sbjct: 729 QRRRQEQEEKRRRRESELQWQEEE------------RAHRQQQEEEQRRDFTWQWQAEEK 776
Query: 818 DAEGQDQDKKSPKPKKKK-------HRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAP 870
G+ + P ++++ R+++E+R +++ K+Q + +Q
Sbjct: 777 SERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ-FLE 835
Query: 871 EEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQ 905
EEEQL L E LQED +
Sbjct: 836 EEEQLQRRERAQQLQEE---------EDGLQEDQE 861
Score = 55.1 bits (131), Expect = 4e-07
Identities = 79/445 (17%), Positives = 195/445 (43%), Gaps = 75/445 (16%)
Query: 444 QQKEQAGEAEGAQAVTQLMVDRLPQFVQSADLEVQERASCILQLVKHIQKLQAKDVPVAE 503
++++Q ++E + Q + R Q + L+ +E + Q +K + + ++ +AE
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 504 EVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPK 563
E + PK Q ++ + P + E +R R +EE+RR +
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP---RKQEGQRRRQ--EQEEKRRRR 742
Query: 564 HRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLK 623
+ EEE A R++ ++++ + + ++ ++ Q ++ PL+
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ-----------RLSARPPLR 791
Query: 624 VPGLPMSDQYVKLEEERRHRQKL-----EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIA 678
++ ++ EE ++ Q+ EK++RR++R+E+EK+ + E +E +
Sbjct: 792 ----EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF------LEEEEQLQ 841
Query: 679 PAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKS 738
++ + EE E+ L D++ + + R D L + K + R+T +K
Sbjct: 842 RRERAQQLQEE--EDGLQEDQERRRSQEQRR--DQKWRWQLEEERK----RRRHTLYAKP 893
Query: 739 PEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAP 798
++ + K+ + +++E++ + +ER+K +++E+E++ +
Sbjct: 894 ALQE--QLRKEQQLLQEEEEELQREEREKRRRQEQERQYRE------------------- 932
Query: 799 VPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHR-----KEKEERTKGKKKSKKQ 853
+ + Q EE+ ++++K+ + +++++R ++KEE+ G++ K++
Sbjct: 933 ----------EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 854 PPGSEEAAGEPVQNGAPEEEQLPPE 878
E+ E + EE+ L E
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREE 1007
Score = 54.3 bits (129), Expect = 6e-07
Identities = 68/381 (17%), Positives = 160/381 (41%), Gaps = 62/381 (16%)
Query: 535 WINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKS 594
W+ E ER + +++ + R + +EEE ++E R+Q+
Sbjct: 457 WLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE------ 510
Query: 595 SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQ--KLEKDKR- 651
++R Q E +Q L S+Q ++ E+E R Q K E++KR
Sbjct: 511 --QEERREQRLKRQEEEERLQQRL----------RSEQQLRREQEERREQLLKREEEKRL 558
Query: 652 ---RKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPY 708
R++++ K ++ +RR L E + Q++ EE E L +E ++ +
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEER---RQQRLKREQEERLEQRLKREEVERLEQEER 615
Query: 709 RALDIDLDKP---------LADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKK 759
R + ++P ++ ++ Q+ E + E+ + E++ + ++ +++
Sbjct: 616 REQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKRE 675
Query: 760 HKEKERDKEKKKEKEKKAED-----LDFWLSTTPPPAPA------PAPAPVPSTDECEDA 808
H+E+ R++E +E++++A + + W A A P ++
Sbjct: 676 HEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQ 735
Query: 809 KTEAQGEEDDAEGQDQDKKSPKPKKKKHRKE-------KEERTKGKKKSKKQPPGSE--- 858
+ + + E + + Q++++ + ++++ R++ +E+ +G+++ +PP E
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795
Query: 859 -----EAAGEPVQNGAPEEEQ 874
E + Q PEEE+
Sbjct: 796 RQLRAEERQQREQRFLPEEEE 816
Score = 53.9 bits (128), Expect = 8e-07
Identities = 63/346 (18%), Positives = 142/346 (41%), Gaps = 45/346 (13%)
Query: 548 ERPRAVFHEEEQ-RRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTP 606
ER R EE+Q R+ +HR +E+ L R E + Q + +++ +++ +D
Sbjct: 1443 ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 607 GVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHR------QKLEKDKRRKKRKEKEK 660
E + + P ++ +L ++R R Q+L + +R ++R++
Sbjct: 1503 FREQ--------ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 661 KGKRRHSSLPTESDEDIAPAQQVDI--------VTEEMPENALPSDEDDKDPNDPYRALD 712
+ R L E +E Q+ D V + E DE + + L
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR 1614
Query: 713 IDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKE 772
+ D+ + E+L + R + E+D +E++ + +++ ++ +RD++ ++E
Sbjct: 1615 QERDRKFREDEQL--LQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREE 1672
Query: 773 KEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPK 832
++ E + L ++ + + EE Q++++K + +
Sbjct: 1673 EQLLQEGEEQQLRR-------------------QERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 833 KKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPE 878
++ R+E E + + +++ +Q E+ + EEEQL PE
Sbjct: 1714 QQLRRQELERKFR-EEEQLRQETEQEQLRRQERYRKILEEEQLRPE 1758
Score = 50.8 bits (120), Expect = 7e-06
Identities = 71/392 (18%), Positives = 152/392 (38%), Gaps = 86/392 (21%)
Query: 542 DSESEDE---RPRAVFHEEEQRRPK---------HRPSEADEEELARRREA--------- 580
D + DE R R + E E+RR + H E +EE RRRE
Sbjct: 165 DRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGRE 224
Query: 581 RKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKL---- 636
KQ+Q +K ++ V ++ P + L ++ ++
Sbjct: 225 EKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQ 284
Query: 637 --------EEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTE 688
EE+++ R + E+ RRK+ +E+ ++ + R ++ QQ+ E
Sbjct: 285 ELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE 344
Query: 689 EMPENALPSDEDD--------KDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPE 740
E E L ++++ ++ + R + ++ L ++L ++ E E
Sbjct: 345 ERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRRE 404
Query: 741 KDVPMVE--------------KKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLST 786
+ + + ++ ++ ++ E+KH+++ R++ K+E+E++ + WL
Sbjct: 405 QQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD----WL-- 458
Query: 787 TPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHR---KEKEER 843
K E + E + E + Q K + ++++ R E+EER
Sbjct: 459 ----------------------KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Query: 844 TKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQL 875
+ +++ ++Q +E E EEE+L
Sbjct: 497 REQQERREQQLRREQEERREQRLKRQEEEERL 528
Score = 50.4 bits (119), Expect = 9e-06
Identities = 55/348 (15%), Positives = 148/348 (42%), Gaps = 18/348 (5%)
Query: 546 EDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDT 605
++++ R +++ R+ + R DE+ L R E + Q + +++ P +++ ++
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 606 PGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEE----RRHRQKLEKDKRRKKRKEKEKK 661
+ H + L G +Q ++ +E R Q+L + +R +K ++E++
Sbjct: 1660 Q-LRHDRDRKFREEEQLLQEG---EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Query: 662 GKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD 721
+R+ +E + + + + + + +E + + + + D+ +
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLD 781
E+L ++ R + +S E D E++ + +++E++ + ++RD + + E+E+ +
Sbjct: 1776 EEQL--RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQ 1833
Query: 782 FWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKE 841
A + ++ + E EE+ Q++++K + ++ +KE++
Sbjct: 1834 EQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893
Query: 842 --------ERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSY 881
+ +GK + PG+ + A PV++ E S Y
Sbjct: 1894 RHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQY 1941
Score = 48.5 bits (114), Expect = 3e-05
Identities = 77/414 (18%), Positives = 155/414 (37%), Gaps = 72/414 (17%)
Query: 535 WINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEE---------LARRREARKQEQ 585
W + E + E + + E E+RR + R + EEE L RE R++++
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Query: 586 ANNPF------------YIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
+ ++ P ++R + +Q + +Q
Sbjct: 1076 LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQE------------EEQL 1123
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKK-------GKRRHSSLPTESDEDIAPAQQVDIV 686
++ E E+R RQ+LE+ R ++ ++E++ KRR L + E+ Q+
Sbjct: 1124 LREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQE---- 1179
Query: 687 TEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMV 746
E L +E +K + ++ + E+L QK + + D+
Sbjct: 1180 -----EEQLLREEQEKRRQ--------ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ 1226
Query: 747 EKKSKKPKKKEKKHKEKERDKEKKKEKE-------KKAEDLDFWLSTTPPPAPAPAPAPV 799
+ K+ ++ K K R+ E+ ++ E + +DL L
Sbjct: 1227 WEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRW 1286
Query: 800 PSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKK--KKHRKEKEERTKGKKKSKKQPPGS 857
D + E E+ E + +D+KS + K+ ++ R+EK R + +K +++
Sbjct: 1287 QQRDR-HFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLL 1345
Query: 858 EEAAGEPVQNGA-----PEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQV 906
+E +P++ EEE E L E ++ R L+E+ Q+
Sbjct: 1346 QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL 1399
Score = 48.1 bits (113), Expect = 5e-05
Identities = 67/374 (17%), Positives = 167/374 (44%), Gaps = 33/374 (8%)
Query: 544 ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQ 603
E + E+ R + + ++ P+ E +E++ A+RR+ + QE+ ++ ++R Q
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQ---LLREEREEKRRRQ 1332
Query: 604 DTPGV--EHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQ---KLEKDKRRKKRKEK 658
+T E ++Q PL+ D+ + EEE RH++ K ++++R +R+E+
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLR---RQERDRKFR-EEELRHQEQGRKFLEEEQRLRRQER 1388
Query: 659 EKKGKRRHSSLPT-ESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDK 717
E+K + L E ++ + + EE + D ++ R + + K
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERER-K 1447
Query: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKE-KKKEKEKK 776
L + ++L ++HR K E++ + E++ ++ ++E+ K E +++ +++E+++K
Sbjct: 1448 FLEEEQQLRQERHR-----KFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRK 1502
Query: 777 AEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQG----EEDDAEGQDQDKKSPKPK 832
+ + + P +E + + + Q EE Q++ ++ + +
Sbjct: 1503 FREQEL---------RSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 833 KKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKM 892
+K R+E++ R + +++ + + E + E+E+ E L + ++
Sbjct: 1554 DRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQL 1613
Query: 893 TCDIRGSLQEDSQV 906
+ +ED Q+
Sbjct: 1614 RQERDRKFREDEQL 1627
Score = 46.6 bits (109), Expect = 1e-04
Identities = 64/349 (18%), Positives = 152/349 (43%), Gaps = 46/349 (13%)
Query: 544 ESEDERPRAVFHE----EEQRRPKHRPSEADEEELAR--RREARKQEQANNPFYIKSSPS 597
E E +R R + +EQ R + + + +EEEL R R + R+QEQ
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER---------- 928
Query: 598 PQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKE 657
Q R ++ E +++ + ++ + E ER++R+ + ++ ++
Sbjct: 929 -QYREEEQLQQEEEQLLREE------------REKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 658 KEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDK 717
+E + +RR +E+ ++ ++ EE + E D + + L +
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLR 1035
Query: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKA 777
+ +L ++ + E E+++ E++ +++ ++ +E ER K++E +++
Sbjct: 1036 EEREKRRLQERERQYRE-----EEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 778 EDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHR 837
E L L P +C + + E Q EE+ ++++K+ + ++++R
Sbjct: 1091 EQL---LREEPEKRRRQ-----ERERQCRE-EEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 838 KEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAE 886
+E+E + + ++ +++P E+ + ++ EEE+L E L E
Sbjct: 1142 EEEEVQQEEEQLLREEP---EKRRRQELERQYREEEELQQEEEQLLREE 1187
Score = 45.8 bits (107), Expect = 2e-04
Identities = 52/311 (16%), Positives = 133/311 (42%), Gaps = 60/311 (19%)
Query: 544 ESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQ 603
E E E E+Q R + R + +EEL R+R+ ++ + + +++ Q
Sbjct: 143 EQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERR--------AEEEQLQ 194
Query: 604 DTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGK 663
G E ++++ EE+ R R+ LE RRK R+EK+++ +
Sbjct: 195 SCKGHE--------------------TEEFPD-EEQLRRRELLE--LRRKGREEKQQQRR 231
Query: 664 RRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDI-DLDKPLADS 722
R + E +E E L +E+ +P R ++ + ++ L
Sbjct: 232 ERQDRVFQEEEEK----------EWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKL 281
Query: 723 EKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDF 782
E+ +++ R E + ++ ++ +++E++ + +E+ + +++++E++ + L
Sbjct: 282 ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR- 340
Query: 783 WLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEE 842
+E + + + EE+ E Q + ++ + ++++ R+E++
Sbjct: 341 -----------------REQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 843 RTKGKKKSKKQ 853
R + + + ++Q
Sbjct: 384 RREQQLRREQQ 394
Score = 45.4 bits (106), Expect = 3e-04
Identities = 61/354 (17%), Positives = 147/354 (41%), Gaps = 54/354 (15%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARK-----------------QE 584
+ E + E + + E+E+RR + +EEEL R++ ++ +E
Sbjct: 1173 EEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKE 1232
Query: 585 QA--NNPFYIKSSPSPQKRY---------QDTPGVEHIPVVQIDLSVPLKVPGLPMSDQY 633
A +N Y K + Q R Q ++H+ Q + + D++
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 634 VKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPEN 693
EEE+ R++ ++ KRR ++ ++EK+ R E ++ + + +E E
Sbjct: 1293 FP-EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Query: 694 ALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKH-----RNTETSKSPEKDVPMVEK 748
L E D+ + K L + ++L Q+ + + + E++ + +
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 749 KSKKPKKKEKKHKEKERDKE--------KKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVP 800
+ +K +++E++ +ERD++ +++E+E+K + + L
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQE------------R 1459
Query: 801 STDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQP 854
E+ + + EE Q++D+K + +++ R+E++ + + ++ ++P
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP 1513
Score = 38.1 bits (87), Expect = 0.047
Identities = 62/378 (16%), Positives = 150/378 (39%), Gaps = 54/378 (14%)
Query: 525 PVPEGLDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSE-ADEEELARRREAR-- 581
P E L+ + D +S++E+ EE+RR + + +EE+L + RE +
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353
Query: 582 ---------KQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMS-D 631
++E+ + + ++R + + L + L D
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRD 1413
Query: 632 QYVKLEEERRHRQ----KLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVT 687
+ + EE++ RQ K +++++ +R+E+E+K L E +Q +
Sbjct: 1414 RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ---LL 1470
Query: 688 EEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVE 747
+E E L E D+ + + L + K Q+ R+ E + ++ +
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQL-----RRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 748 KKSKKPK--KKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDEC 805
++ ++ K ++E++ + +ER +++++++++K
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR--------------------------- 1558
Query: 806 EDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
E+ + + EE Q++D+K ++K R+E+E + ++ ++ G ++ E
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 866 QNGAPEEEQLPPESSYSL 883
+ +E+ L L
Sbjct: 1619 RKFREDEQLLQEREEQQL 1636
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 61.6 bits (148), Expect = 4e-09
Identities = 60/338 (17%), Positives = 132/338 (39%), Gaps = 51/338 (15%)
Query: 544 ESEDERPRAVFHEEEQRRPKHRPSEADEEELAR-RREARKQEQANNPFYIKSSPSPQKRY 602
++E ER R E +++ ++R E + E+ + RRE +Q + N + S ++R
Sbjct: 154 DAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERE 213
Query: 603 QDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKG 662
++ + + E ER+ + E+D++RK +E+EK+
Sbjct: 214 RE---------------------------RETETETERKRQTDRERDRQRKTEREREKQA 246
Query: 663 KRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDED-DKDPNDPYRALDIDLDKPLAD 721
+R +S + TE E D D D+D R D +
Sbjct: 247 ERERAS---------------ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLD 781
++ R + + E++ ++ ++ +++ ++ +E ERD+EK E+E+K +
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREK--ERERKRKRQT 349
Query: 782 FWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKE 841
E E + E + +D+D+ K ++++ K+++
Sbjct: 350 EMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRD 409
Query: 842 -----ERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 874
E+ + ++K ++ G E Q G + +
Sbjct: 410 GQRETEKQREREKDRESERGRERGREREKQKGRERDRE 447
Score = 58.2 bits (139), Expect = 4e-08
Identities = 54/345 (15%), Positives = 146/345 (42%), Gaps = 39/345 (11%)
Query: 541 SDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQK 600
++ E++ +R R + ++R +HR + D E+ R+ R++++ + ++
Sbjct: 71 TERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERE 130
Query: 601 --------RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRR 652
R + T G + + + +D+ + + ER +++ E++K R
Sbjct: 131 TEREGERGRDRQTDGQR-----ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNR 185
Query: 653 KKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD 712
++R+E+E++ ++ + + S+ ++ + TE E +D + R +
Sbjct: 186 QERRERERQREKENKTEDRHSER--GRERERERETETETERKRQTDRERDRQRKTERERE 243
Query: 713 IDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEK---KHKEKERDKEK 769
++ A + K R E + ++D E++ + +K+++ + +E ER +E+
Sbjct: 244 KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRER 303
Query: 770 KKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSP 829
++E+E++ E + + + E + E +D++K+
Sbjct: 304 QRERERERE---------------------RNRKRERERERERERERQRETERDREKERE 342
Query: 830 KPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 874
+ +K++ ++E + ++ ++Q E E + A E E+
Sbjct: 343 RKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Score = 55.1 bits (131), Expect = 4e-07
Identities = 43/224 (19%), Positives = 102/224 (45%), Gaps = 23/224 (10%)
Query: 635 KLEEERRHRQKLEK--DKRRKKRKEKEKKGKR-RHSSLPTESDEDIAPAQQVDIVTEEMP 691
K E RR +++ E+ D++R++R+EK++ KR RH + +++ + +
Sbjct: 60 KERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREK 119
Query: 692 ENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 751
E + + + + R D D + +K R +T + ++ E+ +
Sbjct: 120 ERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQT---ERNRQ 176
Query: 752 KPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTE 811
K +++EK +E+ R++E+++EKE K ED + + +TE
Sbjct: 177 KEREREKNRQER-RERERQREKENKTEDRHSERGR--------------ERERERETETE 221
Query: 812 AQGEEDDAEGQDQDKKSPKPKKKKHRKEK--EERTKGKKKSKKQ 853
+ + +D+ +K+ + ++K+ +E+ E T+ K+ +++
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERE 265
Score = 54.3 bits (129), Expect = 6e-07
Identities = 52/268 (19%), Positives = 114/268 (42%), Gaps = 28/268 (10%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
++E+E ER R + ++ R + R +E + E+ A R A ++E + K + R
Sbjct: 217 ETETETERKR----QTDRERDRQRKTEREREKQAERERASERETERD----KERERERDR 268
Query: 602 YQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKK 661
+D + Q D + D+ + + ER+ ++ E+++ RK+ +E+E++
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTE----RDRETERKRERQRERERERERNRKRERERERE 324
Query: 662 GKR---RHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDI----- 713
+R R + E + + +Q ++ E + + + R D
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE 384
Query: 714 ------DLDKPLADSEKLPIQKHRN--TETSKSPEKDVPMVEKKSKKPKKKEKKHKEKER 765
D D+ + +K R+ ET K E++ ++ ++ ++ +K K +ER
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER 444
Query: 766 DKEKKKEKEKKAEDLDFWLSTTPPPAPA 793
D+E++ +++ + L PPP A
Sbjct: 445 DRERQTDRQAGRQRKRSTLYVNPPPRTA 472
Score = 39.7 bits (91), Expect = 0.016
Identities = 38/247 (15%), Positives = 100/247 (40%), Gaps = 53/247 (21%)
Query: 609 EHIPVVQIDLSVPL----KVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKR 664
+ + + +++++PL + PG S + L + H+ D+ R ++KE+E++ ++
Sbjct: 11 DQLGTLWVEVTIPLDFSRRRPGSQESPRRRGLGQA--HKDADGDDRERNRQKERERRREK 68
Query: 665 RHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEK 724
R Q + T+ E D K R D + ++ +
Sbjct: 69 R----------------QTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112
Query: 725 LPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWL 784
Q+ + K E++ ++ + + ++ +E++RD EK++E++
Sbjct: 113 RDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQ---------- 162
Query: 785 STTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERT 844
TD +TE +++ ++++K + ++++ ++EKE +T
Sbjct: 163 -----------------TDRERQRQTERNRQKE----REREKNRQERRERERQREKENKT 201
Query: 845 KGKKKSK 851
+ + +
Sbjct: 202 EDRHSER 208
Score = 35.8 bits (81), Expect = 0.23
Identities = 33/196 (16%), Positives = 80/196 (40%), Gaps = 13/196 (6%)
Query: 692 ENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSK 751
E +P D + P L + D++ +++R E + EK E K
Sbjct: 19 EVTIPLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRK 78
Query: 752 KPKKKEK-----KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECE 806
+ +++EK + + +ER ++++KE+E++ + E E
Sbjct: 79 RERRREKDRHRKRDRHRERQRDREKERERQTD--------RERDRQREKERNRQKERERE 130
Query: 807 DAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQ 866
+ +G + +GQ + ++ +K++ R+ ER + ++++++ E+ E +
Sbjct: 131 TEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRE 190
Query: 867 NGAPEEEQLPPESSYS 882
E++ E +S
Sbjct: 191 RERQREKENKTEDRHS 206
Score = 33.9 bits (76), Expect = 0.88
Identities = 39/192 (20%), Positives = 75/192 (39%), Gaps = 17/192 (8%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELAR-----RREARKQEQANNPFYIKSSP 596
+ E E +R E+E+ R + R +E D E + RR+A ++ + +S+
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 597 SPQKRYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRK 656
++R +D D + D + E++R + E ++ R++ +
Sbjct: 384 EREERERDRDR---------DRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGR 434
Query: 657 EKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRAL--DID 714
E+EK+ K R ++D ++ + P S DPN P R +
Sbjct: 435 EREKQ-KGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSS 493
Query: 715 LDKPLADSEKLP 726
+ P A S + P
Sbjct: 494 PEDPKAASTRFP 505
>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
[Homo sapiens]
Length = 845
Score = 61.6 bits (148), Expect = 4e-09
Identities = 64/279 (22%), Positives = 117/279 (41%), Gaps = 61/279 (21%)
Query: 637 EEERRHRQKLEKDKRRKKRK--------EKEKKGKRRHSSLPTESDEDIAPAQQV----- 683
+++++ +QK ++D R+ +RK EKE + + S+PT +ED PA +
Sbjct: 66 QQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKK 125
Query: 684 ----DIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSP 739
++ + + + +E++K P P + ++K +++ E+ P K + + KS
Sbjct: 126 TKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSE-EQQPALKGKKGKEEKS- 183
Query: 740 EKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPV 799
K KP+ K +E DKE++ KEK+
Sbjct: 184 --------KGKAKPQNKFAALDNEEEDKEEEIIKEKE----------------------- 212
Query: 800 PSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK---KHRKEKEERTKGKKKSKKQPPG 856
P E AK QG E++ EG++++++ + K H +KE KKK KKQ
Sbjct: 213 PPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKE-----KKKLKKQMEY 267
Query: 857 SEEAAGEPVQNGAPEE---EQLPPESSYSLLAENSYVKM 892
+ A N A + Q S ++L S +K+
Sbjct: 268 ERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKL 306
Score = 46.6 bits (109), Expect = 1e-04
Identities = 61/302 (20%), Positives = 118/302 (39%), Gaps = 38/302 (12%)
Query: 649 DKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPY 708
DK KK K+ +K K L E D+ ++V E+ + + +D
Sbjct: 25 DKVVKKGKKDKKIKKTFFEELAVE-DKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGR 83
Query: 709 RALDID--------------LDKPLADSE-KLPIQKHRNTETSKSPEKDVPMVEKKSKKP 753
R D+D L P +D E ++P K R + +K +++ +S++
Sbjct: 84 RKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEE- 142
Query: 754 KKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQ 813
+++E+KH K EK + + +E+ PA +E K + Q
Sbjct: 143 EEEEEKHPPKPAKPEKNRINKAVSEEQQ------------PALKGKKGKEEKSKGKAKPQ 190
Query: 814 G--------EEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPV 865
EED E ++K+ PK K+K +K ++ + + +++ G E A +P
Sbjct: 191 NKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPY 250
Query: 866 QN-GAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQVTVAIVLENRSSSILKGME 924
+ E+++L + Y + + S+ + + +LEN S L+
Sbjct: 251 AHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFS 310
Query: 925 LS 926
+S
Sbjct: 311 IS 312
Score = 38.9 bits (89), Expect = 0.027
Identities = 49/230 (21%), Positives = 79/230 (34%), Gaps = 75/230 (32%)
Query: 718 PLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKK---------------KEKKHKE 762
P A ++ P + S SP V KK KK KK +EK KE
Sbjct: 2 PKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE 61
Query: 763 KERDKEKKKEKEKKAEDL-----------------------DFWLSTTPPPAPAPAPAPV 799
KE+ ++++++++KK D + T+ PAP P
Sbjct: 62 KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPR 121
Query: 800 PSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKK-----------------KHRKEKEE 842
A ++ E ++++K PKP K K +K KEE
Sbjct: 122 GGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEE 181
Query: 843 RTKGKKK--------------------SKKQPPGSEEAAGEPVQNGAPEE 872
++KGK K +K+PP + + + G+ EE
Sbjct: 182 KSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEE 231
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 61.2 bits (147), Expect = 5e-09
Identities = 75/327 (22%), Positives = 135/327 (41%), Gaps = 62/327 (18%)
Query: 546 EDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDT 605
++ERP +E+ R K R ++D+E + + +K+E+A + + + P+ + +
Sbjct: 1304 KEERPNK---DEKARETKERTPKSDKE----KEKFKKEEKAKDEKFKTTVPNAESKSTQE 1356
Query: 606 PGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRR 665
E P + D++ +K S + VK E+ L+ R E E++ KRR
Sbjct: 1357 REREKEPSRERDIAKEMK------SKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRR 1410
Query: 666 ---------HSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLD 716
HSS +S ++ + + P S E + D D LD
Sbjct: 1411 KIDTHPSPSHSSTVKDSLIELKESS-AKLYINHTPPPLSKSKEREMDKKD--------LD 1461
Query: 717 KPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKK 776
K + R+ E K EKD +KE+K D+E + K+
Sbjct: 1462 K----------SRERSREREKKDEKD------------RKERKRDHSNNDREVPPDLTKR 1499
Query: 777 AEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEE---DDAEGQDQDKKSPKPKK 833
++ + + + + +P +P P+ + E K+++ G+E D + + DK S KK
Sbjct: 1500 RKEENGTMGVSKHKSESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKK 1559
Query: 834 K-KHRKEKEERTKGKKKSKKQPPGSEE 859
+ +H KEK E KK K+ G +E
Sbjct: 1560 ESRHDKEKIE-----KKEKRDSSGGKE 1581
Score = 54.3 bits (129), Expect = 6e-07
Identities = 61/255 (23%), Positives = 106/255 (41%), Gaps = 32/255 (12%)
Query: 647 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPND 706
E DK + K KEKEKK K P + E A+ + +E P+ ++ PN
Sbjct: 1268 ENDKEKGKEKEKEKKEKT-----PATTPE----ARVLGKDGKEKPK--------EERPNK 1310
Query: 707 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKK-HKEKER 765
+A + P +D EK +K + K + VP E KS + +++EK+ +E++
Sbjct: 1311 DEKARETKERTPKSDKEKEKFKKEEKAKDEKF-KTTVPNAESKSTQEREREKEPSRERDI 1369
Query: 766 DKE-KKKEKEKKAEDLDFWLSTTPPPAPAPAPAPV-----------PSTDECEDAKTEA- 812
KE K KE K E S P + P P PS K
Sbjct: 1370 AKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQKRRKIDTHPSPSHSSTVKDSLI 1429
Query: 813 QGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEPVQNGAPEE 872
+ +E A+ P K K+ +K++ K +++S+++ E+ E ++ + +
Sbjct: 1430 ELKESSAKLYINHTPPPLSKSKEREMDKKDLDKSRERSREREKKDEKDRKERKRDHSNND 1489
Query: 873 EQLPPESSYSLLAEN 887
++PP+ + EN
Sbjct: 1490 REVPPDLTKRRKEEN 1504
Score = 48.9 bits (115), Expect = 3e-05
Identities = 44/153 (28%), Positives = 66/153 (43%), Gaps = 23/153 (15%)
Query: 734 ETSKSPEKD---VPMVEKKSKKPKKKEKKHKE---------KERDKEKKKEKEKKAEDLD 781
ET KS E+ V V K S K + KE DKEK KEKEK+ ++
Sbjct: 1226 ETDKSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKE-- 1283
Query: 782 FWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKE 841
TP P A V D E K E +++ A ++ +++PK K+K + +KE
Sbjct: 1284 ----KTPATTPE---ARVLGKDGKEKPKEERPNKDEKA--RETKERTPKSDKEKEKFKKE 1334
Query: 842 ERTKGKKKSKKQPPGSEEAAGEPVQNGAPEEEQ 874
E+ K +K P ++ E + P E+
Sbjct: 1335 EKAKDEKFKTTVPNAESKSTQEREREKEPSRER 1367
Score = 45.1 bits (105), Expect = 4e-04
Identities = 60/259 (23%), Positives = 107/259 (41%), Gaps = 31/259 (11%)
Query: 539 PLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQA-NNPFYIKSSPS 597
P ++S+S ER R E+E R + E +E + E + +P P
Sbjct: 1347 PNAESKSTQERER----EKEPSRERDIAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPE 1402
Query: 598 PQKRYQ----DT-PGVEHIPVVQIDLSVPLKVPGLPMSDQYVK---LEEERRHRQKLEKD 649
P++ + DT P H V+ D + LK + + + + R K + D
Sbjct: 1403 PEREQKRRKIDTHPSPSHSSTVK-DSLIELKESSAKLYINHTPPPLSKSKEREMDKKDLD 1461
Query: 650 KRRKKRKEKEKKG-------KRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDK 702
K R++ +E+EKK KR HS+ E D+ ++ + T + ++ S +
Sbjct: 1462 KSRERSREREKKDEKDRKERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHKSESPCESP 1521
Query: 703 DPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKE 762
PN+ D +K + S K + +++ KS + D K + KEK K+
Sbjct: 1522 YPNEK------DKEKNKSKSSG----KEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKK 1571
Query: 763 KERDKEKKKEKEKKAEDLD 781
++RD KE++K + D
Sbjct: 1572 EKRDSSGGKEEKKHHKSSD 1590
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 60.8 bits (146), Expect = 7e-09
Identities = 74/308 (24%), Positives = 113/308 (36%), Gaps = 49/308 (15%)
Query: 559 QRRPKHRPSEADEEELARRREA-------RKQEQANNPFYIKSSPSPQKRYQDTPGVEHI 611
+RR H P +R + RK + SP P KR+ +P
Sbjct: 632 KRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPR-- 689
Query: 612 PVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPT 671
Q S P G S Q R+ + RR R + KK K+ S P
Sbjct: 690 -APQTSSSPPPVRRGASSSPQ------RRQSPSPSTRPIRRVSRTPEPKKIKKAASPSP- 741
Query: 672 ESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLAD-SEKLPIQKH 730
Q V V+ + P K P P + P + S +P++K
Sbjct: 742 ---------QSVRRVSSSRSVSGSPEPAAKKPPAPPS---PVQSQSPSTNWSPAVPVKKA 789
Query: 731 RNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPP 790
++ S SP ++ KK KKK+KKHK+ ++ K+ KK K++KA + TP
Sbjct: 790 KSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAA 849
Query: 791 APAPAPA-----PVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTK 845
A PV + + ++ ++EA+ DD E KH +EK R+
Sbjct: 850 IAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLE--------------KHLREKALRSM 895
Query: 846 GKKKSKKQ 853
K + Q
Sbjct: 896 RKAQVSPQ 903
Score = 57.0 bits (136), Expect = 1e-07
Identities = 72/350 (20%), Positives = 131/350 (37%), Gaps = 26/350 (7%)
Query: 541 SDSESEDERPRA--VFHEEEQRRPKHRPSEADEEELARR------REARKQEQANNPFYI 592
S S SEDERP+ V + E RR +H PS + +R R R++ + P
Sbjct: 498 SSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRR 557
Query: 593 KSSPSP-----QKRYQDTPGVEHIPVVQIDLSVPL-KVPGLPMSDQYVKLEEERRHRQKL 646
+ SPSP ++R P P P + P+ +Y +R
Sbjct: 558 RRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASP 617
Query: 647 EKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALP-SDEDDKDPN 705
+R+ K + HS P + + + + ++ ++ S + + P
Sbjct: 618 PPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQ 677
Query: 706 DPYRALDIDLDK-PLADSEKLPIQKHRNTETSK--SPEKDVPMVEKKSKKPK-KKEKKHK 761
R + P S P+++ ++ + SP + + S+ P+ KK KK
Sbjct: 678 PNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAA 737
Query: 762 EKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTD-------ECEDAKTEAQG 814
++ + + PP P+P + PST+ + + T +
Sbjct: 738 SPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPS 797
Query: 815 EEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSEEAAGEP 864
+++ + KK K K KKH+K+K+ + K K +K + AA P
Sbjct: 798 PPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTP 847
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/174 (22%), Positives = 71/174 (40%), Gaps = 16/174 (9%)
Query: 618 LSVPLKVPGLPMSDQYVKLEEERRH-----------RQKLEKDKRRKKRKEKEKKGKRRH 666
LS + G+P + +K EE ++ +Q +KDKR K+ KE ++ + R
Sbjct: 110 LSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERS 169
Query: 667 SSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDI-----DLDKPLAD 721
S +P ++ V E + S P A + +L +P
Sbjct: 170 RSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVK 229
Query: 722 SEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEK 775
++ +Q+ +T K P+ E K P+K KK KEKE+ + + + + K
Sbjct: 230 VKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSK 283
Score = 48.9 bits (115), Expect = 3e-05
Identities = 63/334 (18%), Positives = 114/334 (34%), Gaps = 40/334 (11%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARR--REARKQEQANNPFYIKSSPSPQ 599
D ++E+ + E R P+ R S + R RK+ + +P + S SP
Sbjct: 152 DKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPS 211
Query: 600 KRYQDTPGVEHIPVVQIDLSVP-----------LKVPGLPMSDQYVKLEEERRHRQKLEK 648
+ +P + + P LKVP + + E+ +++ EK
Sbjct: 212 PAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEK 271
Query: 649 DKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDP--ND 706
+K R + + + K R S P+ + P ++ + PS P
Sbjct: 272 EKTRPRSRSRSKSRSRTRSRSPSHT----RPRRRHRSRSRSYSPRRRPSPRRRPSPRRRT 327
Query: 707 PYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERD 766
P R + P + P+++ R + S S + PKK K+ R
Sbjct: 328 PPRRMP---PPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRK 384
Query: 767 KEK-------KKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPST----DECEDAKTEAQGE 815
+ + + + + TPPP +P P S + G+
Sbjct: 385 TRRLSPSASPPRRRHRPSP------PATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGK 438
Query: 816 EDDAEG-QDQDKKSPKPKKKKHRKEKEERTKGKK 848
+G + ++ SP PK +K + E KG K
Sbjct: 439 VTKHKGTEKRESPSPAPKPRKVELSESEEDKGGK 472
Score = 47.0 bits (110), Expect = 1e-04
Identities = 81/376 (21%), Positives = 138/376 (36%), Gaps = 67/376 (17%)
Query: 509 FAGELNPVAPKAQKKVP-VPEG-LDLDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRP 566
F GEL P+ AQ+ + +P L+L E + + E E+ ++ ++E +
Sbjct: 101 FMGELWPLLLSAQENIAGIPSAFLELK---KEEIKQRQIEQEKLASMKKQDEDK------ 151
Query: 567 SEADEEELARRREARKQEQANNPFYIKS-SPSPQKRYQDTPGVEHIPVVQIDLSVPLKVP 625
+ D+EE RE K+E++ +P KS SPSP++R S P
Sbjct: 152 DKRDKEEKESSRE--KRERSRSPRRRKSRSPSPRRR-----------------SSP---- 188
Query: 626 GLPMSDQYVKLEEERRH-RQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVD 684
V+ E +R H R + K R EKK K LP S + P+ Q
Sbjct: 189 --------VRRERKRSHSRSPRHRTKSRSPSPAPEKKEKT--PELPEPSVKVKEPSVQEA 238
Query: 685 IVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQKHRNTETSKSPEKDVP 744
T ++ + +P E +P +P P +S+K +K + S+S K
Sbjct: 239 TSTSDILK--VPKPEPIPEPKEP---------SPEKNSKKEK-EKEKTRPRSRSRSKSRS 286
Query: 745 MVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAP------AP 798
+S + ++H+ + R ++ + TPP P P +P
Sbjct: 287 RTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSP--RRRTPPRRMPPPPRHRRSRSP 344
Query: 799 VPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKKKSKKQPPGSE 858
V + + + + + KK PK RK + ++ P S
Sbjct: 345 VRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRP-SP 403
Query: 859 EAAGEPVQNGAPEEEQ 874
A P +P +Q
Sbjct: 404 PATPPPKTRHSPTPQQ 419
Score = 46.2 bits (108), Expect = 2e-04
Identities = 68/342 (19%), Positives = 119/342 (34%), Gaps = 21/342 (6%)
Query: 542 DSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKR 601
+S S +PR V E + + + AD + +RR+ R+Q Q ++ SS S +R
Sbjct: 449 ESPSPAPKPRKVELSESEEDKGGKMAAADSVQ--QRRQYRRQNQQSSSDSGSSSSSEDER 506
Query: 602 YQDTPGVEHIPVVQIDL----SVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKE 657
P H+ ++ S P Q RR R RR++
Sbjct: 507 ----PKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPS 562
Query: 658 KEKKGKRRHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDP-YRALDIDLD 716
+RR + P +P + P P + P+ P R
Sbjct: 563 PAPPPRRRRTPTPPPRRRTPSPPPRR---RSPSPRRYSPPIQRRYSPSPPPKRRTASPPP 619
Query: 717 KPLADSEKLPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKK 776
P + P K R + + ++ P+ +++S K +K R + + +
Sbjct: 620 PPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPN 679
Query: 777 AEDLDFWLSTTPPP-APAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKK 835
S +P P AP + +P P + Q + ++P+PKK K
Sbjct: 680 KRH-----SPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIK 734
Query: 836 HRKEKEERTKGKKKSKKQPPGS-EEAAGEPVQNGAPEEEQLP 876
++ + S + GS E AA +P +P + Q P
Sbjct: 735 KAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSP 776
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 60.1 bits (144), Expect = 1e-08
Identities = 68/321 (21%), Positives = 143/321 (44%), Gaps = 37/321 (11%)
Query: 629 MSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTE 688
+S + KL + + QKL +D+R K +E+ K K + + E I ++ +DI
Sbjct: 2066 LSKEPAKLNKILKALQKLTRDER-KLTQEEIKMTKMKRALFVKERRLSIEQSK-LDIKEW 2123
Query: 689 EMPENALPSDEDDKDPNDPYRALD------IDLDKPLADSEKLPIQKHRNT------ETS 736
+ E +D+K R L I+ ++ + + E +KH E
Sbjct: 2124 DFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEEEGG 2183
Query: 737 KSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKK---AEDLDFWLSTTPPPAPA 793
E+ +P ++++ +K K+ ++ K KE+ + E E + +E+++ L
Sbjct: 2184 IEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESL 2243
Query: 794 PAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKH-RKEKEERTKGKKKSKK 852
S++E E+ + E + EE++ +++++K + ++K KE+EE+ K KK+ KK
Sbjct: 2244 -------SSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKK 2296
Query: 853 QPPGSEEAAGEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQV---TVA 909
+ +E E E+E++ E L++ + +C + + + ++
Sbjct: 2297 EEVQEKEEVFE-------EKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQ 2349
Query: 910 IVLENRSSSILKGME--LSVL 928
L+ + L+G E LS+L
Sbjct: 2350 FKLQEQRRKSLRGRERVLSIL 2370
Score = 45.8 bits (107), Expect = 2e-04
Identities = 71/353 (20%), Positives = 148/353 (41%), Gaps = 53/353 (15%)
Query: 433 QNVVKLYASILQQKEQAGEAEGAQA----VTQLMVDRLPQFVQSADLEVQERASCILQLV 488
+ + K + + +++E+ + G A + V+ LPQ Q+ D + +E A + +L
Sbjct: 1663 KKLAKKWEKVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELE 1722
Query: 489 KHIQKLQAKDVPVAEEVSALFAGELNPVAPKAQKKVPVPEGLDLDAWINEPLSDSESEDE 548
+++L K+ + +E L ++K + E + AW E LS+ E++
Sbjct: 1723 WDMEELSWKEEELNQEEGKL-----------VEEKKKLAEEEEALAWQREKLSEEETKLA 1771
Query: 549 RPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDTPGV 608
+ + +E+++ +H+ +EEE R RK+EQ K QKR + +
Sbjct: 1772 QEEELLIQEKEKLAQHKEKMPEEEE----RLGRKREQ----LIEKKMKLAQKRERWINSM 1823
Query: 609 EHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSS 668
E + ++ L +++K +++ +EKEK +R+ +
Sbjct: 1824 EELTKNKMIL-----------------------YQKKNLAQEKKNLAQEKEKLAQRKENL 1860
Query: 669 LPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQ 728
L + + Q V + + N + + ++K + + I + LA++EK +Q
Sbjct: 1861 LYNKERLTHSKKQLVQVKNKLGMFNKILAQVEEKLTQE--KETVIKKKEKLAETEKKLVQ 1918
Query: 729 KHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLD 781
+K EK + ++K K +K +K E KE+KA +L+
Sbjct: 1919 V--EDSLAKKQEK---LAQEKMKLALEKAMVQGKKRLRGELDIAKEEKALNLE 1966
Score = 43.5 bits (101), Expect = 0.001
Identities = 78/344 (22%), Positives = 148/344 (43%), Gaps = 51/344 (14%)
Query: 572 EELARRREA--RKQEQANNPFYIKSSPSPQKRYQDTPGVEHIPVV-QIDLSVPLKVPGLP 628
+E+ R +E R++EQA QK+ +D G+E V+ + V PG
Sbjct: 1334 QEVIRHKEVMPREEEQA------------QKKARDMLGLEETQVILKKGKKVIFLEPGNV 1381
Query: 629 MSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPTESDEDIAPAQQVDIVTE 688
+ + +EE++ QK K R+ +KE+ K GK + E D ++E
Sbjct: 1382 TMGKEISKKEEKKTFQKSPKQGRKAVQKER-KVGKIKREMTKEERD-----------MSE 1429
Query: 689 EMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEKLPIQ-KHRNTETSKS-----PEKD 742
E+ E A ++ K + + I+ D +K + K + ET KS E +
Sbjct: 1430 EVEEMATLEEKVVKQEG---KLVMIERTPSWQDWKKAWDEWKQVHGETRKSWKAWKEEWE 1486
Query: 743 VPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPST 802
+++++ K + EK E+E +E KK K ++ + + W + +
Sbjct: 1487 KRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQV--WENMLSSKS---------KE 1535
Query: 803 DECEDAKTEAQGEEDDAEGQDQDKKSPKPKKKKHRKEKEERTKGKK-KSKKQPPGSEEAA 861
+ +D + EE EG++++++ + ++ + K R K+ +++K+ E
Sbjct: 1536 QQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQEERKL 1595
Query: 862 GEPVQNGAPEEEQLPPESSYSLLAENSYVKMTCDIRGSLQEDSQ 905
+ + A EE QL E LA+ +YVK+T D R Q + +
Sbjct: 1596 AQEEEKLAQEERQLAQEE--RKLAQ-AYVKITQDDREMAQAEGK 1636
Score = 43.1 bits (100), Expect = 0.001
Identities = 68/341 (19%), Positives = 136/341 (39%), Gaps = 36/341 (10%)
Query: 546 EDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFYIKSSPSPQKRYQDT 605
++E + + EEE+ +EE L ++ + +E + SS S +++Y+D
Sbjct: 1482 KEEWEKRLLQEEEKLHQAGEKLSPEEEMLQEDKKLKWEEWKQVWENMLSSKSKEQQYKDE 1541
Query: 606 PGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKR-RKKRKEKEKKGKR 664
++ L + G Q + EE+RH Q+ K R +KR EKK +
Sbjct: 1542 E--------EVTLEEEVSREGEEKEQQ---VTEEQRHIQEEHKWARIHRKRARAEKKRAQ 1590
Query: 665 RHSSLPTESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALDIDLDKPLADSEK 724
L E ++ +Q+ ++ + + +DD++ +A +E
Sbjct: 1591 EERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDRE---------------MAQAEG 1635
Query: 725 LPIQKHRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWL 784
QK ++ EK EK ++K KK KK ++ R++EK +K K ++ L
Sbjct: 1636 KFAQKEET--LAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAEVKNIL 1693
Query: 785 STTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDDAEGQDQDKKSPKPK----KKKHRKEK 840
+ P E E + + ++ ++++ + K KKK +E+
Sbjct: 1694 AQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKKKLAEEE 1753
Query: 841 EERTKGKKKSKKQP---PGSEEAAGEPVQNGAPEEEQLPPE 878
E ++K ++ EE + + A +E++P E
Sbjct: 1754 EALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEE 1794
Score = 37.4 bits (85), Expect = 0.080
Identities = 73/338 (21%), Positives = 139/338 (41%), Gaps = 63/338 (18%)
Query: 546 EDERPRAVFHEEEQRRPKHRPSEA-----DEEELARRREARKQEQANNPFYIKSSPSPQK 600
++E A H + R K R E +EE+LA+ QE+ K + + K
Sbjct: 1569 QEEHKWARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEER------KLAQAYVK 1622
Query: 601 RYQDTPGVEHIPVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEK 660
QD + L G +S + KL ++R+ K + R++ K +K
Sbjct: 1623 ITQDDREMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKK 1682
Query: 661 KGK---------RRHSSLPTESD----EDIAPAQQVDIVTEEMPENALPSDEDDKDPNDP 707
GK ++ LP ++ AQ+++ + +M E + +E +++
Sbjct: 1683 GGKLAEVKNILAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKL 1742
Query: 708 YRALDIDLDKPLADSEKLPI---QKHRNTETSKSPEKDVPMVEK------KSKKPKKKEK 758
++ K LA+ E+ +K ET + E+++ + EK K K P+++E+
Sbjct: 1743 -----VEEKKKLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEER 1797
Query: 759 KHKEKERDKEKKKEKEKKAEDLDFWLSTTPPPAPAPAPAPVPSTDECEDAKTEAQGEEDD 818
+++E+ EKK + +K E W++ S +E K +++
Sbjct: 1798 LGRKREQLIEKKMKLAQKRER---WIN---------------SMEELTKNKMILYQKKNL 1839
Query: 819 AEGQDQDKKSPKPKKKKHRKEKEERTKGKKK---SKKQ 853
A Q+KK+ +K+K + KE K++ SKKQ
Sbjct: 1840 A----QEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQ 1873
Score = 33.9 bits (76), Expect = 0.88
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 14/144 (9%)
Query: 532 LDAWINEPLSDSESEDERPRAVFHEEEQRRPKHRPSEADEEELARRREARKQEQANNPFY 591
LD + SE E+ER EEE+ R + E EEE ++ K+E+
Sbjct: 2234 LDELEKQESLSSEEEEEREEEEEREEEEVREEEE--ERKEEEEGEEKQVEKEEEE----- 2286
Query: 592 IKSSPSPQKRYQDTPGVEHIPVVQIDLSVPLKVPGL---PMSDQYVKLEEE-RRHRQKLE 647
K +K+ ++ E + + ++ + L ++ LEEE R ++ L+
Sbjct: 2287 -KKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILK 2345
Query: 648 KDKRRKKRKEKEK--KGKRRHSSL 669
K+K+ K ++++ K +G+ R S+
Sbjct: 2346 KEKQFKLQEQRRKSLRGRERVLSI 2369
Score = 31.6 bits (70), Expect = 4.4
Identities = 43/190 (22%), Positives = 73/190 (38%), Gaps = 19/190 (10%)
Query: 612 PVVQIDLSVPLKVPGLPMSDQYVKLEEERRHRQKLEKDKRRKKRKEKEKKGKRRHSSLPT 671
P +D+S+P + L S + + EE K K +RR + K+ K T
Sbjct: 1047 PAFSLDVSMPSE---LKSSLKPPTVSEESEVAIKPSKGQRRGQAGVKKHSQKWLRGLKKT 1103
Query: 672 ESDEDIAPAQQVDIVTEEMPENALPSDEDDKDPNDPYRALD--IDLDKPLADSEKLPIQK 729
+ + + + ++ +E A P + ++ + + I L K + DS++ I K
Sbjct: 1104 KERDSKQMSTEPGLLEDESGTEAAPIEMEEASVYSQWSSSTSVIKLSKDV-DSQEKDISK 1162
Query: 730 HRNTETSKSPEKDVPMVEKKSKKPKKKEKKHKEKERDKEKKKEKEKKAEDLDFWLSTTPP 789
T K + K ++K+ K+ K KKK K+K E TTPP
Sbjct: 1163 DHIALTLK-------------RLQKIRDKRDKKATAQKLKKKHKKKGKEAKVINEETTPP 1209
Query: 790 PAPAPAPAPV 799
P V
Sbjct: 1210 VMEQPVTKKV 1219
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.363
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,906,003
Number of Sequences: 37866
Number of extensions: 2329370
Number of successful extensions: 46690
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 561
Number of HSP's successfully gapped in prelim test: 1204
Number of HSP's that attempted gapping in prelim test: 18852
Number of HSP's gapped (non-prelim): 13354
length of query: 1112
length of database: 18,247,518
effective HSP length: 113
effective length of query: 999
effective length of database: 13,968,660
effective search space: 13954691340
effective search space used: 13954691340
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.