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Search of human proteins with 10863929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10863929 ribonuclease L [Homo sapiens]
(741 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10863929 ribonuclease L [Homo sapiens] 1501 0.0
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 128 2e-29
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 123 7e-28
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 120 6e-27
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 120 6e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 117 4e-26
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 116 7e-26
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 116 7e-26
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 116 7e-26
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 116 7e-26
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 115 1e-25
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 112 9e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 105 2e-22
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 105 2e-22
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 104 3e-22
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 104 3e-22
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 103 6e-22
gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled... 100 4e-21
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 99 1e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 96 9e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 96 9e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 96 9e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 96 9e-20
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 96 1e-19
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 95 2e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 95 2e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 95 2e-19
gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens] 93 8e-19
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 93 1e-18
gi|148596917 fibronectin type III and ankyrin repeat domains 1 [... 92 1e-18
>gi|10863929 ribonuclease L [Homo sapiens]
Length = 741
Score = 1501 bits (3886), Expect = 0.0
Identities = 741/741 (100%), Positives = 741/741 (100%)
Query: 1 MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW 60
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW
Sbjct: 1 MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW 60
Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120
TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE
Sbjct: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120
Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180
CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH
Sbjct: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180
Query: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240
VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK
Sbjct: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240
Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD
Sbjct: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
Query: 301 CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK 360
CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK
Sbjct: 301 CGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGK 360
Query: 361 LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF 420
LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF
Sbjct: 361 LKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTF 420
Query: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480
YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG
Sbjct: 421 YGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCG 480
Query: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE 540
YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE
Sbjct: 481 YTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFE 540
Query: 541 DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG 600
DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG
Sbjct: 541 DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVG 600
Query: 601 NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG 660
NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG
Sbjct: 601 NESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVG 660
Query: 661 DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH 720
DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH
Sbjct: 661 DLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTH 720
Query: 721 SPNKPQCDGAGGASGLASPGC 741
SPNKPQCDGAGGASGLASPGC
Sbjct: 721 SPNKPQCDGAGGASGLASPGC 741
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 128 bits (322), Expect = 2e-29
Identities = 102/298 (34%), Positives = 148/298 (49%), Gaps = 30/298 (10%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
LI A + V +V++LL+ G N+ ++ GGWT L A R D+VELLL HGA+P +
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDM-GGWTALMWACYKGRTDVVELLLSHGANPSVT 133
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
P I AA G ++ L L GA VN D YG T + AA G ++ +K L G
Sbjct: 134 GLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMG 193
Query: 149 ANVN-----------------LRRKTKEDQER------LRKGGATALMDAAEKGHVEVLK 185
A+V+ + KE +R K G TALM A+++GH E+++
Sbjct: 194 ADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Query: 186 ILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLIL 245
LLD G VN D G LI A+ V A LL AD+++RG+ KT L
Sbjct: 254 DLLD-AGTYVNIPDRSGDTVLIGAVRGGHVEIVRA----LLQKYADIDIRGQDNKTALYW 308
Query: 246 AVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD 303
AVEK + +V+ +L Q + + DG+T L+ A +++ ++ ELL +GA D
Sbjct: 309 AVEKGNATMVRDIL-QCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVD 365
Score = 99.0 bits (245), Expect = 1e-20
Identities = 88/305 (28%), Positives = 148/305 (48%), Gaps = 22/305 (7%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
+I V+ E++ ++ LLE +V+ + E G TPL A + +IV+ L+++GA+ L
Sbjct: 9 VINYVEEENIPALKALLEKCKDVD-ERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLE 67
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
+ T I A+ G V +++ L G ++ D G+TA M A G+ ++ L G
Sbjct: 68 DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIH 208
AN ++ ++ AA +GH +++ +LL + GA VN D G L+
Sbjct: 128 ANPSVTGLY----------SVYPIIWAAGRGHADIVHLLL-QNGAKVNCSDKYGTTPLVW 176
Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268
A + +E + HLL GADV+ G T LI+AV+ + V+ +L++ + +N
Sbjct: 177 A---ARKGHLECVKHLLA-MGADVDQEGANSMTALIVAVKGGYTQSVKEILKR-NPNVNL 231
Query: 269 TDSDGKTALLLAVELKLKKIAELLCKRGASTD----CGDLVMTARRNYDH-SLVKVLLSH 323
TD DG TAL++A + +I + L G + GD V+ H +V+ LL
Sbjct: 232 TDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQK 291
Query: 324 GAKED 328
A D
Sbjct: 292 YADID 296
Score = 49.7 bits (117), Expect = 1e-05
Identities = 36/120 (30%), Positives = 66/120 (55%), Gaps = 2/120 (1%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
+LI AV+ V++V+ LL+ A+++ + ++ T L+ AV+ +V +L+ D +
Sbjct: 272 VLIGAVRGGHVEIVRALLQKYADIDIRGQDNK-TALYWAVEKGNATMVRDILQCNPDTEI 330
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP I A ++++++L L KGA V+ D G T + A+ G+ + L L R
Sbjct: 331 CTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTP-LHIAIRGRSRKLAELLLR 389
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 1/86 (1%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
AV+ + +V+ +L+ + ++G TPL A +M ++VELLL GA K
Sbjct: 309 AVEKGNATMVRDILQCNPDTEICTKDGE-TPLIKATKMRNIEVVELLLDKGAKVSAVDKK 367
Query: 92 GATPFILAAIAGSVKLLKLFLSKGAD 117
G TP +A S KL +L L D
Sbjct: 368 GDTPLHIAIRGRSRKLAELLLRNPKD 393
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 123 bits (308), Expect = 7e-28
Identities = 107/332 (32%), Positives = 156/332 (46%), Gaps = 33/332 (9%)
Query: 36 EDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95
E D ++ LL+ GA+VN Q + G T L NA D+V LL+ GAD + +G TP
Sbjct: 523 EREDSIRTLLDNGASVN-QCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTP 581
Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
LAA G K++ + GA++N D G+TA AA G + + L G V+
Sbjct: 582 LTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCAD 641
Query: 156 KTKEDQER--------------LRKG---------GATALMDAAEKGHVEVLKILLDEMG 192
R L+ G G TAL+ AA GH E+++ LLD G
Sbjct: 642 ADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH-G 700
Query: 193 ADVNACDNMGRNALIHALLSSDDSDVEA-ITHLLLDHGADVNVRGERGKTPLILAVEKKH 251
A+VN D GR AL A L S A + LL+D GA+V+ + G TPL++A + H
Sbjct: 701 AEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGH 760
Query: 252 LGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD-----LVM 306
+ +V LLE +++ TD++G+T LL A + + L GA+ D D ++
Sbjct: 761 VDVVDLLLE-GGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLS 819
Query: 307 TARRNYDHSLVKVLLSHGAKEDFHPPAEDWKP 338
A + +V+ LL G E+ H W P
Sbjct: 820 IASAQGNVEVVRTLLDRGLDEN-HRDDAGWTP 850
Score = 108 bits (271), Expect = 1e-23
Identities = 100/303 (33%), Positives = 140/303 (46%), Gaps = 29/303 (9%)
Query: 36 EDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95
++ +++Q L++ GA+VN +++ T + RED + LL +GA NG T
Sbjct: 492 KEQEVLQLLVKAGAHVNSEDDR---TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTL 548
Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
AA +GS+ ++ L +S+GAD+ D +G T AA G K + L GAN+N
Sbjct: 549 LANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANIN--- 605
Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215
T +D G TAL AA GH EV+ LL G V+ D R AL A
Sbjct: 606 HTDQD-------GWTALRSAAWGGHTEVVSALL-YAGVKVDCADADSRTALRAAAWGGH- 656
Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275
E I LL HGA+VN G+T LI A H +V+ LL+ E+N D DG+T
Sbjct: 657 ---EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD-HGAEVNHEDVDGRT 712
Query: 276 ALLLA-----VELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGA 325
AL +A + LL RGA D D ++ A +V +LL GA
Sbjct: 713 ALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGA 772
Query: 326 KED 328
D
Sbjct: 773 DVD 775
Score = 108 bits (271), Expect = 1e-23
Identities = 91/299 (30%), Positives = 147/299 (49%), Gaps = 30/299 (10%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E +L A +V++V+ LL+ G + N +++ GWTPLH A I E L+ GA
Sbjct: 813 EGRTVLSIASAQGNVEVVRTLLDRGLDENHRDD-AGWTPLHMAAFEGHRLICEALIEQGA 871
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
+G PFILA+ G +++ L +++++ + G A AA+ G ++
Sbjct: 872 RTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVEL 931
Query: 144 LYKRGANVN--------------LRRKTKEDQERLRKG---------GATALMDAAEKGH 180
L+ GA+VN L + + L G G TAL + +GH
Sbjct: 932 LFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGH 991
Query: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240
+E++++L+ ADVNA DN R+AL A V+ LL++HGA V+ +G
Sbjct: 992 MEMVQVLI-AYHADVNAADNEKRSALQSAAWQGHVKVVQ----LLIEHGAVVDHTCNQGA 1046
Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
T L +A ++ H+ +VQ LLE + N D G+TA+ +A + +I +LL K GAS+
Sbjct: 1047 TALCIAAQEGHIDVVQVLLEHG-ADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASS 1104
Score = 104 bits (259), Expect = 3e-22
Identities = 97/327 (29%), Positives = 147/327 (44%), Gaps = 39/327 (11%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L+ A VD+V LLEGGA+V+ + G TPL A M +V LL GA
Sbjct: 752 LLVAAYEGHVDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
G T +A+ G+V++++ L +G D N D G+T AA G + L ++G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870
Query: 149 ANVN-------------------------LRRKTKEDQERLRKGGATALMDAAEKGHVEV 183
A N L K+ DQ G AL AA +GH ++
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGY--DGRNALRVAALEGHRDI 928
Query: 184 LKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPL 243
+++L GADVN D GR L L + + E L++GA+V G+T L
Sbjct: 929 VELLFSH-GADVNCKDADGRPTLYILALENQLTMAE----YFLENGANVEASDAEGRTAL 983
Query: 244 ILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD--C 301
++ + H+ +VQ L+ H ++N D++ ++AL A K+ +LL + GA D C
Sbjct: 984 HVSCWQGHMEMVQVLIAY-HADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTC 1042
Query: 302 GD---LVMTARRNYDHSLVKVLLSHGA 325
+ A + +V+VLL HGA
Sbjct: 1043 NQGATALCIAAQEGHIDVVQVLLEHGA 1069
Score = 100 bits (250), Expect = 4e-21
Identities = 84/265 (31%), Positives = 134/265 (50%), Gaps = 19/265 (7%)
Query: 40 LVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILA 99
+V L++ GA V+ +++G TPL A D+V+LLL GAD NG TP + A
Sbjct: 730 VVSLLIDRGAEVDHCDKDG-MTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAA 788
Query: 100 AIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKE 159
A G ++ L GA V+ D G T A+ G V+ ++ L RG + N R
Sbjct: 789 ASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHR----- 843
Query: 160 DQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVE 219
G T L AA +GH + + L+ E GA N DN GR I +L+S + +
Sbjct: 844 -----DDAGWTPLHMAAFEGHRLICEALI-EQGARTNEIDNDGR---IPFILASQEGHYD 894
Query: 220 AITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK-TALL 278
+ +LL++ ++++ RG G+ L +A + H +V+ LL ++N D+DG+ T +
Sbjct: 895 CV-QILLENKSNIDQRGYDGRNALRVAALEGHRDIVE-LLFSHGADVNCKDADGRPTLYI 952
Query: 279 LAVELKLKKIAELLCKRGASTDCGD 303
LA+E +L +AE + GA+ + D
Sbjct: 953 LALENQL-TMAEYFLENGANVEASD 976
Score = 68.6 bits (166), Expect = 2e-11
Identities = 54/195 (27%), Positives = 93/195 (47%), Gaps = 12/195 (6%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A++N+ + + + LE GANV + EG T LH + ++V++L+ + AD
Sbjct: 950 LYILALENQ-LTMAEYFLENGANVEASDAEGR-TALHVSCWQGHMEMVQVLIAYHADVNA 1007
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
+ AA G VK+++L + GA V+ G TA AA G + ++ L +
Sbjct: 1008 ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALI 207
GA+ N + G TA+ AA+ GH +++K+L + +N C + +
Sbjct: 1068 GADPN----------HADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGCSPSPVHTME 1117
Query: 208 HALLSSDDSDVEAIT 222
L S S V+++T
Sbjct: 1118 QKPLQSLSSKVQSLT 1132
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 120 bits (300), Expect = 6e-27
Identities = 97/292 (33%), Positives = 140/292 (47%), Gaps = 30/292 (10%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
LI A V +V+ LL+ GA++ Q E TPL A R+++VELLL GA+ R
Sbjct: 1120 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 1179
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNE--CDFYGFTAFMEAAVYGKVKALKFLYK 146
+ TP LAA G V ++K+ L+ GA++N G + M AA+ G A+K L
Sbjct: 1180 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 1239
Query: 147 RGANVNLRRKT------------------------KEDQERLRKGGATALMDAAEKGHVE 182
G+++N + +T K + E K G T LM+AA G+ E
Sbjct: 1240 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1299
Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242
V ++LLD+ GADVNA AL + D LL+ GA ++VR ++G TP
Sbjct: 1300 VGRVLLDK-GADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTP 1356
Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
L LA HL +VQ LL Q +++ D+ T L+ A K+ L K
Sbjct: 1357 LWLAANGGHLDVVQ-LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 112 bits (279), Expect = 2e-24
Identities = 101/317 (31%), Positives = 151/317 (47%), Gaps = 22/317 (6%)
Query: 21 AAVEDNH--LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78
A E NH L A +LVQ LLE GA++ ++++ G+TPL A +VE+L
Sbjct: 1077 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKK-GFTPLILAATAGHVGVVEIL 1135
Query: 79 LRHGAD-PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
L +GAD ++ TP LA G ++++L L++GA+ + +T AA G
Sbjct: 1136 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 1195
Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA 197
V +K L GA +N R +K G + LM AA GH +K+LLD MG+D+NA
Sbjct: 1196 VNIIKILLNAGAEINSRTGSKL--------GISPLMLAAMNGHTAAVKLLLD-MGSDINA 1246
Query: 198 CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQR 257
RN + ++V LLLD A+V R + G TPL+ A + + +
Sbjct: 1247 QIETNRNTALTLACFQGRTEV---VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1303
Query: 258 LLEQ-EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARRNY 312
LL++ + S TAL +A + K ELL RGA D G+ + N
Sbjct: 1304 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1363
Query: 313 DH-SLVKVLLSHGAKED 328
H +V++L+ GA D
Sbjct: 1364 GHLDVVQLLVQAGADVD 1380
Score = 111 bits (278), Expect = 2e-24
Identities = 105/328 (32%), Positives = 145/328 (44%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A IV+LLL H A
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L GA + + + G T MEA G V+ +
Sbjct: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L + GA +N + KE DQE TALM+A G
Sbjct: 386 LLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG 445
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA + + G
Sbjct: 446 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGASLEEVNDEG 500
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Score = 107 bits (267), Expect = 4e-23
Identities = 106/366 (28%), Positives = 160/366 (43%), Gaps = 55/366 (15%)
Query: 5 DHNNPQEGPTSSSGRRAAVEDNHLLIK-------------------AVQNEDVDLVQQLL 45
DHN P +G VE LL++ A +++V+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 46 EGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSV 105
E GA+ + +E T L A ++ LLL GA + + +P LAA G V
Sbjct: 422 EAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 106 KLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER-- 163
+L L + +GA + E + G+T MEAA G + + L +GAN+N + T+E QE
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ--TEETQETAL 538
Query: 164 --------------LRKGGA-------TALMDAAEKGHVEVLKILLDEMGADVNACDNMG 202
L K GA T LM+AA++GH+E++K LL GA+V+A G
Sbjct: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVHATTATG 597
Query: 203 RNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQE 262
AL +A + + +LL GAD+ E G+TPL+ A H+ VQ L+ +
Sbjct: 598 DTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 263 HIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS-----TDCGDLVMTARRNYDHSLV 317
T ++ T L LA + ELL GA D +++ A + S+V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 318 KVLLSH 323
LL +
Sbjct: 714 CYLLDY 719
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sapiens]
Length = 2352
Score = 120 bits (300), Expect = 6e-27
Identities = 97/292 (33%), Positives = 140/292 (47%), Gaps = 30/292 (10%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
LI A V +V+ LL+ GA++ Q E TPL A R+++VELLL GA+ R
Sbjct: 869 LILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHR 928
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNE--CDFYGFTAFMEAAVYGKVKALKFLYK 146
+ TP LAA G V ++K+ L+ GA++N G + M AA+ G A+K L
Sbjct: 929 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLD 988
Query: 147 RGANVNLRRKT------------------------KEDQERLRKGGATALMDAAEKGHVE 182
G+++N + +T K + E K G T LM+AA G+ E
Sbjct: 989 MGSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1048
Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242
V ++LLD+ GADVNA AL + D LL+ GA ++VR ++G TP
Sbjct: 1049 VGRVLLDK-GADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTP 1105
Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
L LA HL +VQ LL Q +++ D+ T L+ A K+ L K
Sbjct: 1106 LWLAANGGHLDVVQ-LLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVK 1156
Score = 112 bits (279), Expect = 2e-24
Identities = 101/317 (31%), Positives = 151/317 (47%), Gaps = 22/317 (6%)
Query: 21 AAVEDNH--LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELL 78
A E NH L A +LVQ LLE GA++ ++++ G+TPL A +VE+L
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKK-GFTPLILAATAGHVGVVEIL 884
Query: 79 LRHGAD-PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
L +GAD ++ TP LA G ++++L L++GA+ + +T AA G
Sbjct: 885 LDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGY 944
Query: 138 VKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNA 197
V +K L GA +N R +K G + LM AA GH +K+LLD MG+D+NA
Sbjct: 945 VNIIKILLNAGAEINSRTGSKL--------GISPLMLAAMNGHTAAVKLLLD-MGSDINA 995
Query: 198 CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQR 257
RN + ++V LLLD A+V R + G TPL+ A + + +
Sbjct: 996 QIETNRNTALTLACFQGRTEV---VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRV 1052
Query: 258 LLEQ-EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARRNY 312
LL++ + S TAL +A + K ELL RGA D G+ + N
Sbjct: 1053 LLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANG 1112
Query: 313 DH-SLVKVLLSHGAKED 328
H +V++L+ GA D
Sbjct: 1113 GHLDVVQLLVQAGADVD 1129
Score = 111 bits (278), Expect = 2e-24
Identities = 105/328 (32%), Positives = 145/328 (44%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A IV+LLL H A
Sbjct: 266 EGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKA 325
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L GA + + + G T MEA G V+ +
Sbjct: 326 DVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL 385
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L + GA +N + KE DQE TALM+A G
Sbjct: 386 LLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDG 445
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA + + G
Sbjct: 446 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGASLEEVNDEG 500
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 501 YTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADI 560
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGA 588
Score = 107 bits (267), Expect = 4e-23
Identities = 106/366 (28%), Positives = 160/366 (43%), Gaps = 55/366 (15%)
Query: 5 DHNNPQEGPTSSSGRRAAVEDNHLLIK-------------------AVQNEDVDLVQQLL 45
DHN P +G VE LL++ A +++V+ LL
Sbjct: 362 DHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLL 421
Query: 46 EGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSV 105
E GA+ + +E T L A ++ LLL GA + + +P LAA G V
Sbjct: 422 EAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHV 480
Query: 106 KLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER-- 163
+L L + +GA + E + G+T MEAA G + + L +GAN+N + T+E QE
Sbjct: 481 ELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ--TEETQETAL 538
Query: 164 --------------LRKGGA-------TALMDAAEKGHVEVLKILLDEMGADVNACDNMG 202
L K GA T LM+AA++GH+E++K LL GA+V+A G
Sbjct: 539 TLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLL-AAGANVHATTATG 597
Query: 203 RNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQE 262
AL +A + + +LL GAD+ E G+TPL+ A H+ VQ L+ +
Sbjct: 598 DTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKG 653
Query: 263 HIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS-----TDCGDLVMTARRNYDHSLV 317
T ++ T L LA + ELL GA D +++ A + S+V
Sbjct: 654 ANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVV 713
Query: 318 KVLLSH 323
LL +
Sbjct: 714 CYLLDY 719
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 117 bits (293), Expect = 4e-26
Identities = 98/320 (30%), Positives = 145/320 (45%), Gaps = 40/320 (12%)
Query: 37 DVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95
D ++++ L+ GA VN ++ + W TPLH AV E+ V++LL+H AD R KN TP
Sbjct: 53 DAEIIELLILSGARVNAKDSK--WLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTP 110
Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
+AA +VK + + ++VN D G TA AA G + +K L RGAN+N
Sbjct: 111 LHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAF- 169
Query: 156 KTKEDQERLR-------------------------KGGATALMDAAEKGHVEVLKILLDE 190
K+D+ + K T L AA G + V+K LLD
Sbjct: 170 -DKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLD- 227
Query: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
+G D+N + G L A + D + + L+D GA VN + E+G TPL A
Sbjct: 228 LGVDMNEPNAYGNTPLHVACYNGQD----VVVNELIDCGAIVNQKNEKGFTPLHFAAAST 283
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVM 306
H L LL ++N DGKT L + ++ + + GA DC G+ +
Sbjct: 284 HGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPL 343
Query: 307 TARRNYDHS-LVKVLLSHGA 325
Y H L+ L++ GA
Sbjct: 344 HIAARYGHELLINTLITSGA 363
Score = 99.8 bits (247), Expect = 8e-21
Identities = 94/310 (30%), Positives = 138/310 (44%), Gaps = 29/310 (9%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L+ +V N D V LL GANV+ +++ G T LH E+ V+ LL+HGA +LR
Sbjct: 657 LMLSVLNGHTDCVYSLLNKGANVD-AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLR 715
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVN----ECDFYGFTAFMEAAVYGKVKALKFL 144
G TP L+A G + +L L A ++ D +G+TA A G ++ L
Sbjct: 716 DSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELL 775
Query: 145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD-VNACDNMGR 203
+ +E ++ + L A + ++L+D +GA VNA D+ GR
Sbjct: 776 LE-----------QEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR 824
Query: 204 NALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEH 263
L HA +D VE + LLL H A VN GKTPL++A E V+ L+
Sbjct: 825 TPL-HAAAFTD--HVECL-QLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSAS 880
Query: 264 IEINDTDSDGKTALLLAVE--------LKLKKIAELLCKRGASTDCGDLVMTARRNYDHS 315
E+ D+ TAL LA L L+KI + + + A RN
Sbjct: 881 AELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTM 940
Query: 316 LVKVLLSHGA 325
+V+ LL GA
Sbjct: 941 VVQELLGKGA 950
Score = 80.5 bits (197), Expect = 5e-15
Identities = 81/292 (27%), Positives = 125/292 (42%), Gaps = 49/292 (16%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV----LRKKNGA 93
V+ V L+ GA++ ++ TP+H A + + LL+ + A+P ++ NG
Sbjct: 596 VECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGN-AEPQNAVDIQDGNGQ 654
Query: 94 TPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNL 153
TP +L+ + G + L+KGA+V+ D +G TA AV G + + L + GA L
Sbjct: 655 TPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLL 714
Query: 154 RRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLD---EMGADVNACDNMGRNALIHAL 210
R G T + +A GH+ VL LL M A+ DN G AL A
Sbjct: 715 RDSR----------GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWAC 764
Query: 211 LSSDD----------------------------SDVEAITHLLLDH-GAD-VNVRGERGK 240
+ + +D E +L+D GA VN +G+
Sbjct: 765 YNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGR 824
Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292
TPL A H+ +Q LL + ++N DS GKT L++A E E+L
Sbjct: 825 TPLHAAAFTDHVECLQLLL-SHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Score = 78.2 bits (191), Expect = 3e-14
Identities = 70/240 (29%), Positives = 117/240 (48%), Gaps = 18/240 (7%)
Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120
+PLH A +E+L++ D +R +G TP LAA G V+ + + +++GA +
Sbjct: 552 SPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILV 611
Query: 121 CDF-YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKG-GATALMDAAEK 178
D+ T AA G + L+ L + ++ ++ G G T LM +
Sbjct: 612 KDYILKRTPIHAAATNGHSECLRLL--------IGNAEPQNAVDIQDGNGQTPLMLSVLN 663
Query: 179 GHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGER 238
GH + + LL++ GA+V+A D GR AL ++ + V+A LL HGA +R R
Sbjct: 664 GHTDCVYSLLNK-GANVDAKDKWGRTALHRGAVTGHEECVDA----LLQHGAKCLLRDSR 718
Query: 239 GKTPLILAVEKKHLGLVQRLLEQ-EHIEIN--DTDSDGKTALLLAVELKLKKIAELLCKR 295
G+TP+ L+ H+G++ LL+ ++ N D+ G TAL A + ELL ++
Sbjct: 719 GRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQ 778
Score = 74.7 bits (182), Expect = 3e-13
Identities = 62/225 (27%), Positives = 109/225 (48%), Gaps = 15/225 (6%)
Query: 42 QQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAI 101
Q +++ GA ++ +++ G TPLH A + E ++ L+ GAD R +G P LAA+
Sbjct: 323 QTIIQSGAVIDCEDKNGN-TPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAAL 381
Query: 102 AGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161
+G + LS G D++ D +G T AA G ++ L L GA+ N K+D
Sbjct: 382 SGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFN-----KKD- 435
Query: 162 ERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAI 221
K G + L AA + + L L+ GA VN D G L +A ++ D+D + +
Sbjct: 436 ----KFGRSPLHYAAANCNYQCLFALVGS-GASVNDLDERGCTPLHYA--ATSDTDGKCL 488
Query: 222 THLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEI 266
+ LL + A+ +R ++G + + H +Q + + +++
Sbjct: 489 EY-LLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDV 532
Score = 73.2 bits (178), Expect = 8e-13
Identities = 64/203 (31%), Positives = 97/203 (47%), Gaps = 16/203 (7%)
Query: 41 VQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAA 100
++ L+ GA+VN + ++G TPLH R + +++ GA KNG TP +AA
Sbjct: 289 LELLVGNGADVNMKSKDGK-TPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAA 347
Query: 101 IAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKED 160
G L+ ++ GAD + +G AA+ G + L G +++ T +D
Sbjct: 348 RYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDID----TPDD 403
Query: 161 QERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEA 220
G T L AA G++E L +LL+ GAD N D GR+ L +A + + + A
Sbjct: 404 ------FGRTCLHAAAAGGNLECLNLLLN-TGADFNKKDKFGRSPLHYAAANCNYQCLFA 456
Query: 221 ITHLLLDHGADVNVRGERGKTPL 243
L+ GA VN ERG TPL
Sbjct: 457 ----LVGSGASVNDLDERGCTPL 475
Score = 33.5 bits (75), Expect = 0.73
Identities = 33/130 (25%), Positives = 51/130 (39%), Gaps = 10/130 (7%)
Query: 7 NNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNA 66
+N Q S+G+ L+ A +N + V+ L+ + ++ T LH A
Sbjct: 845 HNAQVNSVDSTGKTP-------LMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897
Query: 67 VQMSREDIVELLLRHGADPVLRKKNGA---TPFILAAIAGSVKLLKLFLSKGADVNECDF 123
E L+L D L A TP +AA G +++ L KGA V D
Sbjct: 898 CSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDE 957
Query: 124 YGFTAFMEAA 133
G+T + A
Sbjct: 958 NGYTPALACA 967
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 116 bits (291), Expect = 7e-26
Identities = 107/328 (32%), Positives = 150/328 (45%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A DIV+LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L++GA++ + + G T MEAA G V+ +
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L GA +N + KE DQE TALM+A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA++ + G
Sbjct: 417 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGANLEEVNDEG 471
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGA 559
Score = 69.7 bits (169), Expect = 9e-12
Identities = 55/166 (33%), Positives = 83/166 (50%), Gaps = 18/166 (10%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD-PVLRKKNGATPF 96
V+L L+E GAN+ +EG +TPL A + E++V LLL GA+ ++ T
Sbjct: 451 VELAALLIERGANLEEVNDEG-YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 509
Query: 97 ILAAIAGSVKLLKLFLSKGADVN-ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
LA G ++ + GAD+ C T MEA+ G ++ +K+L GANV+
Sbjct: 510 TLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATT 565
Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201
T G TAL A E GH +V +LL + GAD++ ++M
Sbjct: 566 AT----------GDTALTYACENGHTDVADVLL-QAGADLDKQEDM 600
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/139 (29%), Positives = 69/139 (49%), Gaps = 7/139 (5%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L++A + ++V LL GAN+N Q EE T L A ++ + L++ GAD L
Sbjct: 475 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 533
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
+TP + A+ G ++L+K L+ GA+V+ G TA A G L + G
Sbjct: 534 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 591
Query: 149 ANVNLRRKTKEDQERLRKG 167
A+++ +ED + + +G
Sbjct: 592 ADLD----KQEDMKTILEG 606
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 116 bits (291), Expect = 7e-26
Identities = 107/328 (32%), Positives = 150/328 (45%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A DIV+LLL H A
Sbjct: 226 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 285
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L++GA++ + + G T MEAA G V+ +
Sbjct: 286 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 345
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L GA +N + KE DQE TALM+A G
Sbjct: 346 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 405
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA++ + G
Sbjct: 406 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGANLEEVNDEG 460
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 461 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 520
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 521 ELGCSTPLMEASQEGHLELVKYLLASGA 548
Score = 69.7 bits (169), Expect = 9e-12
Identities = 55/166 (33%), Positives = 83/166 (50%), Gaps = 18/166 (10%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGAD-PVLRKKNGATPF 96
V+L L+E GAN+ +EG +TPL A + E++V LLL GA+ ++ T
Sbjct: 440 VELAALLIERGANLEEVNDEG-YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETAL 498
Query: 97 ILAAIAGSVKLLKLFLSKGADVN-ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
LA G ++ + GAD+ C T MEA+ G ++ +K+L GANV+
Sbjct: 499 TLACCGGFSEVADFLIKAGADIELGCS----TPLMEASQEGHLELVKYLLASGANVHATT 554
Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201
T G TAL A E GH +V +LL + GAD++ ++M
Sbjct: 555 AT----------GDTALTYACENGHTDVADVLL-QAGADLDKQEDM 589
Score = 52.8 bits (125), Expect = 1e-06
Identities = 41/139 (29%), Positives = 69/139 (49%), Gaps = 7/139 (5%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L++A + ++V LL GAN+N Q EE T L A ++ + L++ GAD L
Sbjct: 464 LMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL- 522
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
+TP + A+ G ++L+K L+ GA+V+ G TA A G L + G
Sbjct: 523 --GCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAG 580
Query: 149 ANVNLRRKTKEDQERLRKG 167
A+++ +ED + + +G
Sbjct: 581 ADLD----KQEDMKTILEG 595
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 116 bits (291), Expect = 7e-26
Identities = 107/328 (32%), Positives = 150/328 (45%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A DIV+LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L++GA++ + + G T MEAA G V+ +
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L GA +N + KE DQE TALM+A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA++ + G
Sbjct: 417 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGANLEEVNDEG 471
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGA 559
Score = 116 bits (290), Expect = 9e-26
Identities = 95/292 (32%), Positives = 140/292 (47%), Gaps = 30/292 (10%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
LI A V +V+ LL+ G ++ Q E TPL A R+++V+LLL GA+ R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNE--CDFYGFTAFMEAAVYGKVKALKFLYK 146
+ TP LAA G V ++K+ L+ GA++N G + M AA+ G V A+K L
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 147 RGANVNLRRKT------------------------KEDQERLRKGGATALMDAAEKGHVE 182
G+++N + +T K + E K G T LM+AA G+ E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242
V ++LLD+ GADVNA AL + D LL+ GA ++VR ++G TP
Sbjct: 1272 VGRVLLDK-GADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
L LA H +VQ LL Q +++ D+ T L+ A K+ + L K
Sbjct: 1329 LWLASNGGHFDVVQ-LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 105 bits (263), Expect = 1e-22
Identities = 95/314 (30%), Positives = 148/314 (47%), Gaps = 36/314 (11%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
+D+V+ LLE GA+ + +E T L A ++ LLL GA + + +P
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
LAA G V+L L + +GA++ E + G+T MEAA G + + L +GAN+N + T
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ--T 501
Query: 158 KEDQER----------------LRKGGA-------TALMDAAEKGHVEVLKILLDEMGAD 194
+E QE L K GA T LM+A+++GH+E++K LL GA+
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS-GAN 560
Query: 195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGL 254
V+A G AL +A + + +LL GAD+ E G+TPL+ A HL
Sbjct: 561 VHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
Query: 255 VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS-----TDCGDLVMTAR 309
VQ L+ + T ++ T + LA + ELL GA D +++ A
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
Query: 310 RNYDHSLVKVLLSH 323
+ ++V LL +
Sbjct: 677 KGGHTNVVSYLLDY 690
Score = 89.0 bits (219), Expect = 1e-17
Identities = 91/319 (28%), Positives = 133/319 (41%), Gaps = 52/319 (16%)
Query: 50 NVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLK 109
+++ E T L A E++V +L+ A R K G TP ILAA AG V +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 110 LFLSKGADV----------------------------------NECDFYGFTAFMEAAVY 135
+ L KG D+ + +T AA
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 136 GKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195
G V +K L GA +N R +K G + LM AA GHV +K+LLD MG+D+
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKL--------GISPLMLAAMNGHVPAVKLLLD-MGSDI 1216
Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255
NA RN + ++V LLLD A+V R + G TPL+ A + +
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEV---VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 256 QRLLEQ-EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARR 310
+ LL++ + S TAL +A + K ELL RGA D G+ +
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 311 NYDH-SLVKVLLSHGAKED 328
N H +V++L+ GA D
Sbjct: 1334 NGGHFDVVQLLVQAGADVD 1352
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/124 (31%), Positives = 56/124 (45%), Gaps = 2/124 (1%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV-L 87
L A +N D+ LL+ GA++ E EGG TPL A + V+ L+ GA+
Sbjct: 572 LTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
N T LA G + +++L L+ GAD G T +EAA G + +L
Sbjct: 631 TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Query: 148 GANV 151
NV
Sbjct: 691 PNNV 694
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 116 bits (291), Expect = 7e-26
Identities = 107/328 (32%), Positives = 150/328 (45%), Gaps = 31/328 (9%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
E LL A +L Q LL ANV + +G TPL A DIV+LLL H A
Sbjct: 237 EGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDA 296
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
D + G T A G V ++K+ L++GA++ + + G T MEAA G V+ +
Sbjct: 297 DVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARV 356
Query: 144 LYKRGANVNLR-RKTKE-----------------------DQERLRKGGATALMDAAEKG 179
L GA +N + KE DQE TALM+A G
Sbjct: 357 LLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDG 416
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
HVEV ++LLD GA VN + + L L++ VE + LL++ GA++ + G
Sbjct: 417 HVEVARLLLDS-GAQVNMPADSFESPL---TLAACGGHVE-LAALLIERGANLEEVNDEG 471
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST 299
TPL+ A + H +V LL Q T+ +TAL LA ++A+ L K GA
Sbjct: 472 YTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADI 531
Query: 300 D--CGDLVMTARRNYDHSLVKVLLSHGA 325
+ C +M A + LVK LL+ GA
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGA 559
Score = 116 bits (290), Expect = 9e-26
Identities = 95/292 (32%), Positives = 140/292 (47%), Gaps = 30/292 (10%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
LI A V +V+ LL+ G ++ Q E TPL A R+++V+LLL GA+ R
Sbjct: 1092 LILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHR 1151
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNE--CDFYGFTAFMEAAVYGKVKALKFLYK 146
+ TP LAA G V ++K+ L+ GA++N G + M AA+ G V A+K L
Sbjct: 1152 NVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLD 1211
Query: 147 RGANVNLRRKT------------------------KEDQERLRKGGATALMDAAEKGHVE 182
G+++N + +T K + E K G T LM+AA G+ E
Sbjct: 1212 MGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAE 1271
Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242
V ++LLD+ GADVNA AL + D LL+ GA ++VR ++G TP
Sbjct: 1272 VGRVLLDK-GADVNAPPVPSSRDT--ALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTP 1328
Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCK 294
L LA H +VQ LL Q +++ D+ T L+ A K+ + L K
Sbjct: 1329 LWLASNGGHFDVVQ-LLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVK 1379
Score = 105 bits (263), Expect = 1e-22
Identities = 95/314 (30%), Positives = 148/314 (47%), Gaps = 36/314 (11%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
+D+V+ LLE GA+ + +E T L A ++ LLL GA + + +P
Sbjct: 385 LDMVRFLLEAGADQEHKTDEMH-TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLT 443
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
LAA G V+L L + +GA++ E + G+T MEAA G + + L +GAN+N + T
Sbjct: 444 LAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ--T 501
Query: 158 KEDQER----------------LRKGGA-------TALMDAAEKGHVEVLKILLDEMGAD 194
+E QE L K GA T LM+A+++GH+E++K LL GA+
Sbjct: 502 EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLAS-GAN 560
Query: 195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGL 254
V+A G AL +A + + +LL GAD+ E G+TPL+ A HL
Sbjct: 561 VHATTATGDTALTYACENGHTD----VADVLLQAGADLEHESEGGRTPLMKAARAGHLCT 616
Query: 255 VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS-----TDCGDLVMTAR 309
VQ L+ + T ++ T + LA + ELL GA D +++ A
Sbjct: 617 VQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAA 676
Query: 310 RNYDHSLVKVLLSH 323
+ ++V LL +
Sbjct: 677 KGGHTNVVSYLLDY 690
Score = 89.0 bits (219), Expect = 1e-17
Identities = 91/319 (28%), Positives = 133/319 (41%), Gaps = 52/319 (16%)
Query: 50 NVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLK 109
+++ E T L A E++V +L+ A R K G TP ILAA AG V +++
Sbjct: 1046 DIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVE 1105
Query: 110 LFLSKGADV----------------------------------NECDFYGFTAFMEAAVY 135
+ L KG D+ + +T AA
Sbjct: 1106 ILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASG 1165
Query: 136 GKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195
G V +K L GA +N R +K G + LM AA GHV +K+LLD MG+D+
Sbjct: 1166 GYVNIIKILLNAGAEINSRTGSKL--------GISPLMLAAMNGHVPAVKLLLD-MGSDI 1216
Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255
NA RN + ++V LLLD A+V R + G TPL+ A + +
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEV---VSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1273
Query: 256 QRLLEQ-EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARR 310
+ LL++ + S TAL +A + K ELL RGA D G+ +
Sbjct: 1274 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLAS 1333
Query: 311 NYDH-SLVKVLLSHGAKED 328
N H +V++L+ GA D
Sbjct: 1334 NGGHFDVVQLLVQAGADVD 1352
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/124 (31%), Positives = 56/124 (45%), Gaps = 2/124 (1%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV-L 87
L A +N D+ LL+ GA++ E EGG TPL A + V+ L+ GA+
Sbjct: 572 LTYACENGHTDVADVLLQAGADLE-HESEGGRTPLMKAARAGHLCTVQFLISKGANVNRA 630
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
N T LA G + +++L L+ GAD G T +EAA G + +L
Sbjct: 631 TANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLDY 690
Query: 148 GANV 151
NV
Sbjct: 691 PNNV 694
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 115 bits (289), Expect = 1e-25
Identities = 97/321 (30%), Positives = 149/321 (46%), Gaps = 42/321 (13%)
Query: 37 DVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95
D ++++ L+ GA VN ++ W TPLH AV E+ V++L++H AD R KN TP
Sbjct: 28 DAEIIELLILSGARVNAKDNM--WLTPLHRAVASRSEEAVQVLIKHSADVNARDKNWQTP 85
Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
+AA +VK ++ + + VN D G TA AA+ G V+ + L +GAN+N
Sbjct: 86 LHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANIN--A 143
Query: 156 KTKEDQERLR-------------------------KGGATALMDAAEKGHVEVLKILLDE 190
K+D+ L K G T L AA G + V+K LL+
Sbjct: 144 FDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLN- 202
Query: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
+G +++ + G AL A + D A+ + L+D+GA+VN G TPL A
Sbjct: 203 LGVEIDEINVYGNTALHIACYNGQD----AVVNELIDYGANVNQPNNNGFTPLHFAAAST 258
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTAL-LLAVELKLKKIAELLCKRGASTDC----GDLV 305
H L LL ++N DGK+ L + AV + + ++ L + G DC G+
Sbjct: 259 HGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR-SQTLIQNGGEIDCVDKDGNTP 317
Query: 306 MTARRNYDHS-LVKVLLSHGA 325
+ Y H L+ L + GA
Sbjct: 318 LHVAARYGHELLINTLRTSGA 338
Score = 83.2 bits (204), Expect = 8e-16
Identities = 91/326 (27%), Positives = 145/326 (44%), Gaps = 23/326 (7%)
Query: 23 VEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI-VELLLRH 81
V N L A N +V +L++ GANVN Q G+TPLH A + + +ELL+ +
Sbjct: 212 VYGNTALHIACYNGQDAVVNELIDYGANVN-QPNNNGFTPLHFAAASTHGALCLELLVNN 270
Query: 82 GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141
GAD ++ K+G +P + A+ G + + G +++ D G T AA YG +
Sbjct: 271 GADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLI 330
Query: 142 KFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201
L GA D + L AA H + + LL G +++ D
Sbjct: 331 NTLRTSGA----------DTAKCGIHSMFPLHLAALNAHSDCCRKLLSS-GFEIDTPDKF 379
Query: 202 GRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261
GR L HA ++ +VE I LL GAD + + + G+TPL A H ++ L+
Sbjct: 380 GRTCL-HA--AAAGGNVECI-KLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLV-T 434
Query: 262 EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLL 321
+N+TD G+TAL A + + +L G + D + + AR + + L
Sbjct: 435 TGANVNETDDWGRTALHYAAASDMDRNKTIL---GNAHDNSEELERARELKEKE-ATLCL 490
Query: 322 SHGAKEDFHPPAEDWKPQSS-HWGAA 346
+ D +P D + +S H+ AA
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAA 516
Score = 75.1 bits (183), Expect = 2e-13
Identities = 80/302 (26%), Positives = 135/302 (44%), Gaps = 43/302 (14%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAV--QMSREDIV-------------- 75
A N ++ L+ GANVN + ++ G T LH A M R +
Sbjct: 420 AAANCHFHCIETLVTTGANVN-ETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERA 478
Query: 76 ------------ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECD 122
E LL++ A+P +R K G AA G + L+L L + + E D
Sbjct: 479 RELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESD 538
Query: 123 FYGFTAFMEAAVY-GKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHV 181
+ + A Y G +AL+ L + ++++R + G TAL AA KGH
Sbjct: 539 SGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEK----------GRTALDLAAFKGHT 588
Query: 182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKT 241
E ++ L++ GA + DN+ + +HA + + + + + D+ V+V+ +G+T
Sbjct: 589 ECVEALINP-GASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
Query: 242 PLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC 301
PL+LAV H+ V LLE+E ++ D G TAL + ++ ++L ++ S C
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKE-ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILC 706
Query: 302 GD 303
D
Sbjct: 707 KD 708
Score = 73.2 bits (178), Expect = 8e-13
Identities = 74/287 (25%), Positives = 119/287 (41%), Gaps = 37/287 (12%)
Query: 42 QQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAI 101
Q L++ G ++ +++G TPLH A + E ++ L GAD + P LAA+
Sbjct: 298 QTLIQNGGEIDCVDKDGN-TPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAAL 356
Query: 102 AGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161
+ LS G +++ D +G T AA G V+ +K L GA+ + K+D
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFH-----KKD- 410
Query: 162 ERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD------ 215
K G T L AA H ++ L+ GA+VN D+ GR AL +A S D
Sbjct: 411 ----KCGRTPLHYAAANCHFHCIETLV-TTGANVNETDDWGRTALHYAAASDMDRNKTIL 465
Query: 216 ------------------SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQR 257
+ LL + A+ ++R + G + A H ++
Sbjct: 466 GNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLEL 525
Query: 258 LLEQEHIEINDTDSDG-KTALLLAVELKLKKIAELLCKRGASTDCGD 303
LLE+ + ++DS K+ L LA + E+L + D D
Sbjct: 526 LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRD 572
Score = 71.2 bits (173), Expect = 3e-12
Identities = 76/271 (28%), Positives = 107/271 (39%), Gaps = 26/271 (9%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L+ AV +D V LLE ANV+ + G T LH + E+ V++LL + +
Sbjct: 649 LMLAVAYGHIDAVSLLLEKEANVDTVDILG-CTALHRGIMTGHEECVQMLLEQEVSILCK 707
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDF---YGFTAFMEAAVYGKVKALKFLY 145
G TP AA G L L +C F G+T A G ++ L
Sbjct: 708 DSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Query: 146 KRGANVNLRRKTKEDQERLRK---GGATALMDAAEKGHVEVLKILLDEMGADVNAC-DNM 201
+Q+ RK T L A H +LL + + + +C D+
Sbjct: 768 --------------EQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDK 813
Query: 202 GRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261
GR L A + VE + LLL H A VN GKT L++A E G V L+
Sbjct: 814 GRTPLRAAAFADH---VECL-QLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 262 EHIEINDTDSDGKTALLLAVELKLKKIAELL 292
++ D D T L LA +K A L+
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGHEKCALLI 900
Score = 68.6 bits (166), Expect = 2e-11
Identities = 91/332 (27%), Positives = 137/332 (41%), Gaps = 66/332 (19%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A N D ++LL G ++ ++ G T LH A + ++LL GAD + K
Sbjct: 354 AALNAHSDCCRKLLSSGFEIDTPDKFGR-TCLHAAAAGGNVECIKLLQSSGADFHKKDKC 412
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAA---------VYGKVK--- 139
G TP AA ++ ++ GA+VNE D +G TA AA + G
Sbjct: 413 GRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNS 472
Query: 140 ----------------ALKFLYKRGANVNLRRKTKEDQ-----------------ERLRK 166
L+FL + AN ++R K + ER
Sbjct: 473 EELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNS 532
Query: 167 G------GATA--LMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
G GAT L AA GH + L++LL + D++ D GR AL A V
Sbjct: 533 GFEESDSGATKSPLHLAAYNGHHQALEVLLQSL-VDLDIRDEKGRTALDLAAFKGHTECV 591
Query: 219 EAITHLLLDHGADVNVRGERGK-TPLILAVEKKHLGLVQRLLE----QEHIEINDTDSDG 273
EA L++ GA + V+ K TPL +V H ++ LLE E +++ D + G
Sbjct: 592 EA----LINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD--AKG 645
Query: 274 KTALLLAVELKLKKIAELLCKRGASTDCGDLV 305
+T L+LAV LL ++ A+ D D++
Sbjct: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDIL 677
Score = 67.0 bits (162), Expect = 6e-11
Identities = 60/221 (27%), Positives = 99/221 (44%), Gaps = 15/221 (6%)
Query: 43 QLLEGGANVNFQEEEGGWT--PLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAA 100
+LL N F+E + G T PLH A +E+LL+ D +R + G T LAA
Sbjct: 524 ELLLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAA 583
Query: 101 IAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY-GKVKALKFLYKRGANVNLRRKTKE 159
G + ++ ++ GA + D + A+V G L+ L + N E
Sbjct: 584 FKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADN-------PE 636
Query: 160 DQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVE 219
+ G T LM A GH++ + +LL E A+V+ D +G AL +++ + V+
Sbjct: 637 AVDVKDAKGQTPLMLAVAYGHIDAVSLLL-EKEANVDTVDILGCTALHRGIMTGHEECVQ 695
Query: 220 AITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260
+LL+ + + RG+TPL A + H + LL+
Sbjct: 696 ----MLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ 732
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 112 bits (281), Expect = 9e-25
Identities = 95/286 (33%), Positives = 146/286 (51%), Gaps = 23/286 (8%)
Query: 26 NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGAD 84
++ L++A + D++ V+QL NVN ++ EG TPLH A +R +VE LL HGAD
Sbjct: 651 DYRLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGAD 709
Query: 85 PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144
+ K G P A G ++ +L + GA VN D + FT EAA GK + K L
Sbjct: 710 VHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLL 769
Query: 145 YKRGAN-----------VNLRRKTKEDQERLRKGGATALMDAAEKGHV-EVLKILLDEMG 192
K GA+ ++L ++ D + L +G A AL+DAA+KG + V K+ E
Sbjct: 770 LKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDA-ALLDAAKKGCLARVQKLCTPE-- 826
Query: 193 ADVNACDNMGRNAL-IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251
++N D GRN+ +H L++ +++E + LL+HGADVN + + G PL A H
Sbjct: 827 -NINCRDTQGRNSTPLH--LAAGYNNLE-VAEYLLEHGADVNAQDKGGLIPLHNAASYGH 882
Query: 252 LGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGA 297
+ + L++ +N TD T L A + ++ LL GA
Sbjct: 883 VDIAALLIKYNTC-VNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 927
Score = 101 bits (252), Expect = 2e-21
Identities = 88/280 (31%), Positives = 135/280 (48%), Gaps = 17/280 (6%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWT-PLHNAVQMSREDIVELLLRHGADPVL 87
L++A +N DV V++L++ ANVN ++ G + PLH A R+D+VE LL+ GA+
Sbjct: 186 LLEACRNGDVSRVKRLVDA-ANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHA 244
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
R G P A G +++ L L +GAD N D + +T EAA+ GK+ L +
Sbjct: 245 RDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQH 304
Query: 148 GANVNLRRKTKEDQERLRKGGATA----------LMDAAEKGHVEVLKILLDEMGADVNA 197
GA+ N+R + L A A L++AA G+ E L LL + + +A
Sbjct: 305 GADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHA 364
Query: 198 CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQR 257
D ++ +H L++ + V I LLL HGADV+ + + G PL A H + +
Sbjct: 365 SDGR-KSTPLH--LAAGYNRVR-IVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTEL 420
Query: 258 LLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGA 297
LL+ +N D T L A ++ LL GA
Sbjct: 421 LLKHGAC-VNAMDLWQFTPLHEAASKNRVEVCSLLLSHGA 459
Score = 94.4 bits (233), Expect = 3e-19
Identities = 85/262 (32%), Positives = 125/262 (47%), Gaps = 18/262 (6%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVL 87
L++A ++ + + + LL NVN +G TPLH A +R IV+LLL+HGAD
Sbjct: 339 LLEAARSGNEEKLMALLTP-LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHA 397
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
+ K G P A G ++ +L L GA VN D + FT EAA +V+ L
Sbjct: 398 KDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSH 457
Query: 148 GAN---VNLRRK-------TKEDQERL--RKGGATALMDAAEKGHVEVLKILLDEMGADV 195
GA+ VN K T E +ERL G + L A E +V K L E+ +
Sbjct: 458 GADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI---I 514
Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255
N +H ++S + +T LLL GA+VN + + TPL +A E+ H V
Sbjct: 515 NFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAH-NDV 573
Query: 256 QRLLEQEHIEINDTDSDGKTAL 277
+L + ++N D+ G+TAL
Sbjct: 574 MEVLHKHGAKMNALDTLGQTAL 595
Score = 90.1 bits (222), Expect = 7e-18
Identities = 92/347 (26%), Positives = 136/347 (39%), Gaps = 76/347 (21%)
Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 86
H + ++ + + + LL GANVN ++ + TPLH A + + D++E+L +HGA
Sbjct: 527 HCAVASLHPKRKQVTELLLRKGANVN-EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMN 585
Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTA------------------ 128
G T AA+AG ++ +L LS G+D + GFTA
Sbjct: 586 ALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPI 645
Query: 129 --------FMEAAVYGKVKALKFL------------------------YKRGANVNLRRK 156
+EA+ G ++ +K L Y R + V
Sbjct: 646 RTSDVDYRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLH 705
Query: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
D KGG L +A GH EV ++L+ GA VN D + + +H +
Sbjct: 706 HGADVHAKDKGGLVPLHNACSYGHYEVAELLV-RHGASVNVAD-LWKFTPLHEAAAKGKY 763
Query: 217 DVEAITHLLLDHGADVNVRGERGKTPLIL--------------------AVEKKHLGLVQ 256
+ I LLL HGAD + G TPL L A +K L VQ
Sbjct: 764 E---ICKLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQ 820
Query: 257 RLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD 303
+L E+I DT T L LA ++AE L + GA + D
Sbjct: 821 KLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQD 867
Score = 77.8 bits (190), Expect = 3e-14
Identities = 84/322 (26%), Positives = 137/322 (42%), Gaps = 32/322 (9%)
Query: 13 PTSSSGRRAAVE-DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQM-- 69
PT R E H L++A + D+ V++ L +NF++ + T LH AV
Sbjct: 476 PTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEI-INFKQPQSHETALHCAVASLH 534
Query: 70 -SREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTA 128
R+ + ELLLR GA+ + K+ TP +AA ++++ GA +N D G TA
Sbjct: 535 PKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTA 594
Query: 129 FMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188
AA+ G ++ + L G++ ++ + G TA A+ G+ V +IL
Sbjct: 595 LHRAALAGHLQTCRLLLSYGSDPSI----------ISLQGFTA----AQMGNEAVQQILS 640
Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248
+ + D L +S D+E + L + R TPL A
Sbjct: 641 ESTPIRTSDVD-------YRLLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHFAAG 693
Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL---- 304
+ +V+ LL +++ D G L A ++AELL + GAS + DL
Sbjct: 694 YNRVSVVEYLLHHG-ADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFT 752
Query: 305 -VMTARRNYDHSLVKVLLSHGA 325
+ A + + K+LL HGA
Sbjct: 753 PLHEAAAKGKYEICKLLLKHGA 774
Score = 76.3 bits (186), Expect = 1e-13
Identities = 101/365 (27%), Positives = 137/365 (37%), Gaps = 106/365 (29%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
D+V+ LL+ GANV+ +++ GG PLHNA ++V LLL GADP R TP
Sbjct: 230 DVVEHLLQMGANVHARDD-GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHE 288
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAF--------------------MEAAVYGKV 138
AAI G + + + L GAD N + G +A +EAA G
Sbjct: 289 AAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNE 348
Query: 139 KALKFL------------------------YKRGANVNLRRKTKEDQERLRKGGATALMD 174
+ L L Y R V L + D KGG L +
Sbjct: 349 EKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHN 408
Query: 175 AAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD--- 231
A GH EV ++LL GA VNA D + + +H S + +V LLL HGAD
Sbjct: 409 ACSYGHYEVTELLLKH-GACVNAMD-LWQFTPLHEAASKNRVEV---CSLLLSHGADPTL 463
Query: 232 VNVRG----ERGKTPLI---------------------LAVEKKHLGL------------ 254
VN G + TP + LA KK L L
Sbjct: 464 VNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHE 523
Query: 255 ----------------VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS 298
V LL ++ +N+ + D T L +A E + E+L K GA
Sbjct: 524 TALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAK 583
Query: 299 TDCGD 303
+ D
Sbjct: 584 MNALD 588
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/160 (29%), Positives = 73/160 (45%), Gaps = 9/160 (5%)
Query: 2 ESRDHNNP----QEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEE 57
++RD N P +EG T + + L+ A + + VQ+L N+N ++ +
Sbjct: 779 KNRDGNTPLDLVKEGDTDIQD---LLRGDAALLDAAKKGCLARVQKLCTP-ENINCRDTQ 834
Query: 58 G-GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGA 116
G TPLH A + ++ E LL HGAD + K G P AA G V + L +
Sbjct: 835 GRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNT 894
Query: 117 DVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
VN D + FT EAA G+ + L GA+ ++ +
Sbjct: 895 CVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQ 934
Score = 48.1 bits (113), Expect = 3e-05
Identities = 25/62 (40%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
VD+ L++ VN ++ +TPLH A Q R + LLL HGADP ++ + G TP
Sbjct: 883 VDIAALLIKYNTCVN-ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLD 941
Query: 98 LA 99
LA
Sbjct: 942 LA 943
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 105 bits (262), Expect = 2e-22
Identities = 94/286 (32%), Positives = 141/286 (49%), Gaps = 19/286 (6%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHG 82
E + L++A + DV+ V++L +VN ++ EG TPLH A +R +VE LL+HG
Sbjct: 491 EADRQLLEAAKAGDVETVKKLCTV-QSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHG 549
Query: 83 ADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALK 142
AD + K G P A G ++ +L + GA VN D + FT EAA GK + K
Sbjct: 550 ADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICK 609
Query: 143 FLYKRGANVNLRRKTKEDQERLRKGGAT----------ALMDAAEKGHVEVLKILLDEMG 192
L + GA+ + + L K G T AL+DAA+KG + +K L
Sbjct: 610 LLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKL--SSP 667
Query: 193 ADVNACDNMGRNAL-IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKH 251
+VN D GR++ +H L++ +++E + LL HGADVN + + G PL A H
Sbjct: 668 DNVNCRDTQGRHSTPLH--LAAGYNNLE-VAEYLLQHGADVNAQDKGGLIPLHNAASYGH 724
Query: 252 LGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGA 297
+ V LL + + +N TD T L A + ++ LL GA
Sbjct: 725 VD-VAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGA 769
Score = 90.1 bits (222), Expect = 7e-18
Identities = 89/298 (29%), Positives = 134/298 (44%), Gaps = 18/298 (6%)
Query: 12 GPTSSSGRRAAVEDN-HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQM 69
G +S AVE L +A +N DV+ V++L+ VN ++ G TPLH A
Sbjct: 10 GAACASAAAEAVEPAARELFEACRNGDVERVKRLVTP-EKVNSRDTAGRKSTPLHFAAGF 68
Query: 70 SREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAF 129
R+D+VE LL++GA+ R G P A G +++ L L GAD N D + +T
Sbjct: 69 GRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPL 128
Query: 130 MEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATA----------LMDAAEKG 179
EAA+ GK+ L + GA +R L A A L+++A G
Sbjct: 129 HEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSG 188
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
+ E + LL + + +A D ++ +H L++ + V+ I LLL HGADV+ + +
Sbjct: 189 NEEKMMALLTPLNVNCHASDGR-KSTPLH--LAAGYNRVK-IVQLLLQHGADVHAKDKGD 244
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGA 297
PL A H V LL + +N D T L A ++ LL GA
Sbjct: 245 LVPLHNACSYGHYE-VTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGA 301
Score = 86.3 bits (212), Expect = 1e-16
Identities = 86/288 (29%), Positives = 126/288 (43%), Gaps = 17/288 (5%)
Query: 50 NVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108
NVN +G TPLH A +R IV+LLL+HGAD + K P A G ++
Sbjct: 201 NVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVT 260
Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN---VNLRRKTKED----- 160
+L + GA VN D + FT EAA +V+ L GA+ +N K+ D
Sbjct: 261 ELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTP 320
Query: 161 --QERL--RKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
+ERL G + L A E + K L EM VN +H +S
Sbjct: 321 QLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEM---VNFKHPQTHETALHCAAASPYP 377
Query: 217 DVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTA 276
+ I LLL GA++N + + TPL +A EK H +V+ +++ E ++N D+ G+T+
Sbjct: 378 KRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHE-AKVNALDNLGQTS 436
Query: 277 LLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHG 324
L A + LL G + L + V+ LL G
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEG 484
Score = 83.6 bits (205), Expect = 6e-16
Identities = 94/356 (26%), Positives = 137/356 (38%), Gaps = 80/356 (22%)
Query: 40 LVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILA 99
+ + LL GAN+N + +E TPLH A + + D+VE++++H A G T A
Sbjct: 382 ICELLLRKGANINEKTKEF-LTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRA 440
Query: 100 AIAGSVKLLKLFLSKGADVNECDFYGFTAF--------------------------MEAA 133
A G ++ +L LS G D N GFTA +EAA
Sbjct: 441 AYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAA 500
Query: 134 VYGKVKALKFL------------------------YKRGANVNLRRKTKEDQERLRKGGA 169
G V+ +K L Y R + V + D KGG
Sbjct: 501 KAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGL 560
Query: 170 TALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG 229
L +A GH EV ++L+ GA VN D + + +H + + I LLL HG
Sbjct: 561 VPLHNACSYGHYEVAELLVKH-GAVVNVAD-LWKFTPLHEAAAKGKYE---ICKLLLQHG 615
Query: 230 ADVNVRGERGKTPLIL--------------------AVEKKHLGLVQRLLEQEHIEINDT 269
AD + G TPL L A +K L V++L +++ DT
Sbjct: 616 ADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDT 675
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGD----LVMTARRNYDHSLVKVLL 321
T L LA ++AE L + GA + D + + +Y H V LL
Sbjct: 676 QGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALL 731
Score = 60.5 bits (145), Expect = 6e-09
Identities = 47/131 (35%), Positives = 64/131 (48%), Gaps = 6/131 (4%)
Query: 50 NVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108
NVN ++ +G TPLH A + ++ E LL+HGAD + K G P AA G V +
Sbjct: 669 NVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVA 728
Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168
L + A VN D + FT EAA G+ + L GA+ L K +E Q L
Sbjct: 729 ALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTL--KNQEGQTPLDLVS 786
Query: 169 A---TALMDAA 176
A +AL+ AA
Sbjct: 787 ADDVSALLTAA 797
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/76 (30%), Positives = 36/76 (47%), Gaps = 5/76 (6%)
Query: 255 VQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAST----DCGDLVMTARR 310
V+RL+ E + DT T L A K + E L + GA+ D G + +
Sbjct: 40 VKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNAC 99
Query: 311 NYDHS-LVKVLLSHGA 325
++ H+ +V +LL HGA
Sbjct: 100 SFGHAEVVNLLLRHGA 115
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 105 bits (261), Expect = 2e-22
Identities = 93/288 (32%), Positives = 139/288 (48%), Gaps = 24/288 (8%)
Query: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAG 103
LL+ AN N + G+TPLH A + +R ++ELLL+HGA ++G TP +AA G
Sbjct: 386 LLDKKANPN-AKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
Query: 104 SVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER 163
V ++ + GA N + G TA AA G+ + +++L + GA V K K+DQ
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQV--EAKAKDDQ-- 500
Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
T L +A G ++++ LL + GA NA G L H DV A
Sbjct: 501 ------TPLHISARLGKADIVQQLL-QQGASPNAATTSGYTPL-HLSAREGHEDVAA--- 549
Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
LLDHGA +++ ++G TPL +A + L V LL Q+ + G T L +A
Sbjct: 550 FLLDHGASLSITTKKGFTPLHVAAKYGKLE-VANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 284 KLKKIAELLCKRGASTDCG------DLVMTARRNYDHSLVKVLLSHGA 325
+K+A LL +GAS L + A++N + LL +GA
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKN-QMDIATTLLEYGA 655
Score = 102 bits (254), Expect = 1e-21
Identities = 87/300 (29%), Positives = 142/300 (47%), Gaps = 22/300 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A ++ ++V+ L++ GA V + ++ TPLH + ++ + DIV+ LL+ GA P +
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQ-TPLHISARLGKADIVQQLLQQGASPNAATTS 531
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP L+A G + L GA ++ GFT AA YGK++ L ++ A+
Sbjct: 532 GYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS- 590
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
+ K G T L AA + +V +LLD+ GA +A G L H
Sbjct: 591 ---------PDAAGKSGLTPLHVAAHYDNQKVALLLLDQ-GASPHAAAKNGYTPL-HIAA 639
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ D+ LL++GAD N +G + LA ++ H+ +V LL + + +N ++
Sbjct: 640 KKNQMDIATT---LLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGR-NANVNLSNK 695
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDC----GDLVMTARRNYDH-SLVKVLLSHGAK 326
G T L LA + +AE+L +GA D G + +Y + +V LL H AK
Sbjct: 696 SGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAK 755
Score = 95.1 bits (235), Expect = 2e-19
Identities = 76/236 (32%), Positives = 110/236 (46%), Gaps = 16/236 (6%)
Query: 57 EGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGA 116
+ G TPLH A + + LLL GA P KNG TP +AA + + L GA
Sbjct: 596 KSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGA 655
Query: 117 DVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAA 176
D N G + AA G V + L R ANVNL K+ G T L AA
Sbjct: 656 DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS----------GLTPLHLAA 705
Query: 177 EKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRG 236
++ V V ++L+++ GA V+A MG L + +++ I + LL H A VN +
Sbjct: 706 QEDRVNVAEVLVNQ-GAHVDAQTKMGYTPL---HVGCHYGNIK-IVNFLLQHSAKVNAKT 760
Query: 237 ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292
+ G TPL A ++ H ++ LL Q + N+ +G TAL +A L + + L
Sbjct: 761 KNGYTPLHQAAQQGHTHIINVLL-QNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 91.3 bits (225), Expect = 3e-18
Identities = 81/300 (27%), Positives = 134/300 (44%), Gaps = 24/300 (8%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + + ++V+ LL+ GA ++ + +G TPLH + E +VE+LL A + + KN
Sbjct: 275 ASKRGNANMVKLLLDRGAKIDAKTRDG-LTPLHCGARSGHEQVVEMLLDRAAPILSKTKN 333
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G +P +A + ++L L V++ TA AA G K K L + AN
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N + G T L A +K ++V+++LL + GA + A G + A
Sbjct: 394 NAK----------ALNGFTPLHIACKKNRIKVMELLL-KHGASIQAVTESGLTPIHVAAF 442
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V + H HGA N RG+T L +A +V R L Q+ ++
Sbjct: 443 MGHVNIVSQLMH----HGASPNTTNVRGETALHMAARSGQAEVV-RYLVQDGAQVEAKAK 497
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCG------DLVMTARRNYDHSLVKVLLSHGA 325
D +T L ++ L I + L ++GAS + L ++AR ++ + LL HGA
Sbjct: 498 DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHE-DVAAFLLDHGA 556
Score = 82.0 bits (201), Expect = 2e-15
Identities = 74/285 (25%), Positives = 130/285 (45%), Gaps = 21/285 (7%)
Query: 16 SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV 75
S R+ + N ++A + ++ ++ G ++N + G LH A + ++V
Sbjct: 32 SRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNG-LNALHLASKEGHVEVV 90
Query: 76 ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY 135
LL+ A+ K G T +A++AG +++K+ ++ GA+VN GFT AA
Sbjct: 91 SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 136 GKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195
++ +KFL GA+ +L ED G T L A ++GH +V+ +LL+
Sbjct: 151 NHLEVVKFLLDNGASQSL---ATED-------GFTPLAVALQQGHDQVVSLLLE------ 194
Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255
N R +H DD+ A LLL + + +V + G TPL +A ++ +
Sbjct: 195 NDTKGKVRLPALHIAARKDDTKAAA---LLLQNDNNADVESKSGFTPLHIAAHYGNINVA 251
Query: 256 QRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
LL + ++ T + T L +A + + +LL RGA D
Sbjct: 252 TLLLNRA-AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID 295
Score = 80.1 bits (196), Expect = 7e-15
Identities = 76/292 (26%), Positives = 125/292 (42%), Gaps = 30/292 (10%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + +D LL+ N + E + G+TPLH A ++ LLL A +N
Sbjct: 209 AARKDDTKAAALLLQNDNNADV-ESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
TP +A+ G+ ++KL L +GA ++ G T A G + ++ L R A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 152 NLRRK---------TKEDQ--------------ERLRKGGATALMDAAEKGHVEVLKILL 188
+ K T+ D + + TAL AA GH +V K+LL
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 189 DEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVE 248
D+ A+ NA N ++ + ++ + LLL HGA + E G TP+ +A
Sbjct: 388 DKK-ANPNA---KALNGFTPLHIACKKNRIK-VMELLLKHGASIQAVTESGLTPIHVAAF 442
Query: 249 KKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
H+ +V +L+ N T+ G+TAL +A ++ L + GA +
Sbjct: 443 MGHVNIVSQLM-HHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493
Score = 74.7 bits (182), Expect = 3e-13
Identities = 86/331 (25%), Positives = 138/331 (41%), Gaps = 51/331 (15%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L A Q +++V+ LL+ GA+ + E+G +TPL A+Q + +V LLL + +R
Sbjct: 144 LYMAAQENHLEVVKFLLDNGASQSLATEDG-FTPLAVALQQGHDQVVSLLLENDTKGKVR 202
Query: 89 -----------------------------KKNGATPFILAAIAGSVKLLKLFLSKGADVN 119
K+G TP +AA G++ + L L++ A V+
Sbjct: 203 LPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVD 262
Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179
T A+ G +K L RGA ++ KT++ G T L A G
Sbjct: 263 FTARNDITPLHVASKRGNANMVKLLLDRGAKID--AKTRD--------GLTPLHCGARSG 312
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERG 239
H +V+++LLD ++ N + L + D LLL H V+
Sbjct: 313 HEQVVEMLLDRAAPILSKTKNG-----LSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDY 367
Query: 240 KTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGAS- 298
T L +A H + + LL+++ N +G T L +A + K+ ELL K GAS
Sbjct: 368 LTALHVAAHCGHYKVAKVLLDKK-ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASI 426
Query: 299 ---TDCGDLVMTARRNYDH-SLVKVLLSHGA 325
T+ G + H ++V L+ HGA
Sbjct: 427 QAVTESGLTPIHVAAFMGHVNIVSQLMHHGA 457
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 104 bits (259), Expect = 3e-22
Identities = 86/261 (32%), Positives = 134/261 (51%), Gaps = 18/261 (6%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
D V+ LL GA V+ ++ WTPL A +++ L+ HGA+P+L+ K+G F +
Sbjct: 85 DCVRYLLGRGAAVDCLKK-ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI 143
Query: 99 AAIAGSVKLLKLFLS--KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
A+ G +L+ L+ GA E T AA++G ++A+K L KR
Sbjct: 144 ASREGDPLILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKR--------- 193
Query: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
+ + + G TALMDA + GH++V ++LLDE GA ++A D++G AL A ++ D
Sbjct: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQD- 252
Query: 217 DVEAITHLLLDHGADVNVRG-ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275
EAI L+ + G DV+VR T L A ++ H +Q LL +IN D ++
Sbjct: 253 --EAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSL-GADINSKDEKNRS 309
Query: 276 ALLLAVELKLKKIAELLCKRG 296
AL LA + A+ L + G
Sbjct: 310 ALHLACAGQHLACAKFLLQSG 330
Score = 67.0 bits (162), Expect = 6e-11
Identities = 72/253 (28%), Positives = 118/253 (46%), Gaps = 26/253 (10%)
Query: 18 GRRAAVE-----DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRE 72
GR AAV+ D L+ A +++ ++Q+L+E GAN + ++ GW H A +
Sbjct: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKD-GWNSFHIASREGDP 150
Query: 73 DIVELLLR--HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAF 129
I++ LL GA K TP AA+ G ++ +K+ L + + + D G TA
Sbjct: 151 LILQYLLTVCPGAWKT-ESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTAL 209
Query: 130 MEAAVYGKVKALKFLY-KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188
M+A G + + L + GA ++ GA AL AA G E ++ L+
Sbjct: 210 MDAIQCGHIDVARLLLDEHGACLSAEDSL----------GAQALHRAAVTGQDEAIRFLV 259
Query: 189 DEMGADVNA-CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 247
E+G DV+ + AL +A S ++ LL GAD+N + E+ ++ L LA
Sbjct: 260 SELGVDVDVRATSTHLTALHYAAKEGHTSTIQT----LLSLGADINSKDEKNRSALHLAC 315
Query: 248 EKKHLGLVQRLLE 260
+HL + LL+
Sbjct: 316 AGQHLACAKFLLQ 328
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/93 (34%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227
G T L AA GH +VL L + G D+ A N +H S D LL
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRD---CVRYLLG 92
Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260
GA V+ + TPL++A +K+LG++Q L+E
Sbjct: 93 RGAAVDCLKKADWTPLMMACTRKNLGVIQELVE 125
Score = 31.6 bits (70), Expect = 2.8
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
G G T L A H ++ L E ++I T+ D K L A + + L R
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
GA+ DC L+M R + +++ L+ HGA
Sbjct: 94 GAAVDCLKKADWTPLMMACTRK-NLGVIQELVEHGA 128
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 104 bits (259), Expect = 3e-22
Identities = 86/261 (32%), Positives = 134/261 (51%), Gaps = 18/261 (6%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
D V+ LL GA V+ ++ WTPL A +++ L+ HGA+P+L+ K+G F +
Sbjct: 85 DCVRYLLGRGAAVDCLKK-ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI 143
Query: 99 AAIAGSVKLLKLFLS--KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
A+ G +L+ L+ GA E T AA++G ++A+K L KR
Sbjct: 144 ASREGDPLILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKR--------- 193
Query: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
+ + + G TALMDA + GH++V ++LLDE GA ++A D++G AL A ++ D
Sbjct: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQD- 252
Query: 217 DVEAITHLLLDHGADVNVRG-ERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKT 275
EAI L+ + G DV+VR T L A ++ H +Q LL +IN D ++
Sbjct: 253 --EAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSL-GADINSKDEKNRS 309
Query: 276 ALLLAVELKLKKIAELLCKRG 296
AL LA + A+ L + G
Sbjct: 310 ALHLACAGQHLACAKFLLQSG 330
Score = 67.0 bits (162), Expect = 6e-11
Identities = 72/253 (28%), Positives = 118/253 (46%), Gaps = 26/253 (10%)
Query: 18 GRRAAVE-----DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRE 72
GR AAV+ D L+ A +++ ++Q+L+E GAN + ++ GW H A +
Sbjct: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKD-GWNSFHIASREGDP 150
Query: 73 DIVELLLR--HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAF 129
I++ LL GA K TP AA+ G ++ +K+ L + + + D G TA
Sbjct: 151 LILQYLLTVCPGAWKT-ESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTAL 209
Query: 130 MEAAVYGKVKALKFLY-KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188
M+A G + + L + GA ++ GA AL AA G E ++ L+
Sbjct: 210 MDAIQCGHIDVARLLLDEHGACLSAEDSL----------GAQALHRAAVTGQDEAIRFLV 259
Query: 189 DEMGADVNA-CDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAV 247
E+G DV+ + AL +A S ++ LL GAD+N + E+ ++ L LA
Sbjct: 260 SELGVDVDVRATSTHLTALHYAAKEGHTSTIQT----LLSLGADINSKDEKNRSALHLAC 315
Query: 248 EKKHLGLVQRLLE 260
+HL + LL+
Sbjct: 316 AGQHLACAKFLLQ 328
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/93 (34%), Positives = 45/93 (48%), Gaps = 4/93 (4%)
Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227
G T L AA GH +VL L + G D+ A N +H S D LL
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEA-TNRDYKRPLHEAASMGHRD---CVRYLLG 92
Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260
GA V+ + TPL++A +K+LG++Q L+E
Sbjct: 93 RGAAVDCLKKADWTPLMMACTRKNLGVIQELVE 125
Score = 31.6 bits (70), Expect = 2.8
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
G G T L A H ++ L E ++I T+ D K L A + + L R
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
GA+ DC L+M R + +++ L+ HGA
Sbjct: 94 GAAVDCLKKADWTPLMMACTRK-NLGVIQELVEHGA 128
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 103 bits (257), Expect = 6e-22
Identities = 95/328 (28%), Positives = 144/328 (43%), Gaps = 56/328 (17%)
Query: 37 DVDLVQQLLEGGANVNFQEEEGGW-TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATP 95
DV ++Q LL GANVN ++ W TPLH A E ++ LLL H AD R K TP
Sbjct: 53 DVPILQLLLMSGANVNAKDTL--WLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTP 110
Query: 96 FILAAI---------------------------------AGSVKLLKLFLSKGADVNECD 122
+AA +G ++ + L L+KGA +N CD
Sbjct: 111 LHVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCD 170
Query: 123 FYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVE 182
AA G ++ LK L RGA++ + + G L AA G +E
Sbjct: 171 KKERQPLHWAAFLGHLEVLKLLVARGADLGCKDRK----------GYGLLHTAAASGQIE 220
Query: 183 VLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTP 242
V+K LL MGA+++ + G AL A D A+ L++ GA+VN ++G TP
Sbjct: 221 VVKYLL-RMGAEIDEPNAFGNTALHIACYLGQD----AVAIELVNAGANVNQPNDKGFTP 275
Query: 243 LILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC- 301
L +A + L LL ++N +GK+ L +A +++L + G+ DC
Sbjct: 276 LHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEIDCA 335
Query: 302 ---GDLVMTARRNYDHS-LVKVLLSHGA 325
G+ + Y H L+ L+++GA
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGA 363
Score = 90.1 bits (222), Expect = 7e-18
Identities = 81/279 (29%), Positives = 131/279 (46%), Gaps = 17/279 (6%)
Query: 22 AVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRH 81
++ D L++A+ + DV+ V+ LL N+N ++E TPLH A + I++LLL
Sbjct: 5 SITDQPPLVQAIFSRDVEEVRSLLSQKENINVLDQERR-TPLHAAAYVGDVPILQLLLMS 63
Query: 82 GADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKAL 141
GA+ + TP AA + + K+L L L+ ADVN D T AA K
Sbjct: 64 GANVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCA 123
Query: 142 KFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNM 201
+ L +++N+ ++ G +AL A GH+E + +LL++ GA +N CD
Sbjct: 124 EALAPLLSSLNVADRS----------GRSALHHAVHSGHLETVNLLLNK-GASLNVCDKK 172
Query: 202 GRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQ 261
R L A + LL+ GAD+ + +G L A + +V+ LL
Sbjct: 173 ERQPLHWAAFLGH----LEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRM 228
Query: 262 EHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
EI++ ++ G TAL +A L +A L GA+ +
Sbjct: 229 -GAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVN 266
Score = 85.5 bits (210), Expect = 2e-16
Identities = 73/244 (29%), Positives = 115/244 (47%), Gaps = 15/244 (6%)
Query: 56 EEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKG 115
+ G + LH+AV + V LLL GA + K P AA G +++LKL +++G
Sbjct: 137 DRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARG 196
Query: 116 ADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDA 175
AD+ D G+ AA G+++ +K+L + GA + + G TAL A
Sbjct: 197 ADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAEI----------DEPNAFGNTALHIA 246
Query: 176 AEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVR 235
G + + I L GA+VN ++ G L A +S++ + LL+++GADVN +
Sbjct: 247 CYLGQ-DAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGA---LCLELLVNNGADVNYQ 302
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
+ GK+PL +A Q +L Q EI+ D G T L +A + + L
Sbjct: 303 SKEGKSPLHMAAIHGRFTRSQ-ILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTN 361
Query: 296 GAST 299
GA T
Sbjct: 362 GADT 365
Score = 82.8 bits (203), Expect = 1e-15
Identities = 85/293 (29%), Positives = 131/293 (44%), Gaps = 18/293 (6%)
Query: 43 QLLEGGANVNFQEEEGGWTPLH-NAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAI 101
+L+ GANVN Q + G+TPLH AV + +ELL+ +GAD + K G +P +AAI
Sbjct: 257 ELVNAGANVN-QPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAI 315
Query: 102 AGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQ 161
G ++ + G++++ D +G T AA YG + L GA+ R+ D
Sbjct: 316 HGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGADT--ARRGIHDM 373
Query: 162 ERLRKGGATALMDAAEK----GHV-EVLKILLDE----MGADVNACDNMGRNALIHALLS 212
L D K G + ++ L +E G D+N DN+GR L HA S
Sbjct: 374 FPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCL-HAAAS 432
Query: 213 SDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSD 272
+VE + +LLL GAD+ R + G+TPL A L+ +N+ D
Sbjct: 433 G--GNVECL-NLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLV-TAGAGVNEADCK 488
Query: 273 GKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGA 325
G + L A + AE + + + +RR ++ LL +GA
Sbjct: 489 GCSPLHYAAASDTYRRAEPHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGA 541
Score = 82.0 bits (201), Expect = 2e-15
Identities = 96/343 (27%), Positives = 138/343 (40%), Gaps = 44/343 (12%)
Query: 17 SGRRAAVED------NHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMS 70
SG RA + D L+ A+ N VD V LLE G+ + + G T LH
Sbjct: 674 SGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGR-TALHRGAVTG 732
Query: 71 REDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECD----FYGF 126
ED + LL H A + R G TP LA+ G +L+ L + D + G+
Sbjct: 733 CEDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGY 792
Query: 127 TAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKI 186
+ A+ G L+ L + L T L A ++
Sbjct: 793 SPMHWASYTGHEDCLELLLEHSPF-----------SYLEGNPFTPLHCAVINNQDSTTEM 841
Query: 187 LLDEMGAD-VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLIL 245
LL +GA VN+ D GR L A + + S + +LL H A+VN G+T L+
Sbjct: 842 LLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLR----MLLQHQAEVNATDHTGRTALMT 897
Query: 246 AVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLV 305
A E V+ LL + ++ D + TAL LA +K A ++ + D G +
Sbjct: 898 AAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMIL--AETQDLGLIN 955
Query: 306 MT----------ARRNYDHSLVKVLLSHGA-----KEDFHPPA 333
T A RN S+V+ LLSHGA E+ H PA
Sbjct: 956 ATNSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPA 998
Score = 77.8 bits (190), Expect = 3e-14
Identities = 87/300 (29%), Positives = 125/300 (41%), Gaps = 39/300 (13%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHG--ADPV 86
L A + + V+ L GA+ +E + WTPLH A D + LL+ G AD
Sbjct: 622 LFLATERGSTECVEVLTAHGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSGERADIT 681
Query: 87 -LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY 145
+ G TP +LA + G V + L L KG+ + D G TA AV G L L
Sbjct: 682 DVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALL 741
Query: 146 KRGANVNLRR-KTKEDQERLRKGGATALMD--------------------------AAEK 178
A V R K + G TA++ A+
Sbjct: 742 DHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYT 801
Query: 179 GHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD-VNVRGE 237
GH + L++LL+ + + + L A++++ DS E + L GA VN R
Sbjct: 802 GHEDCLELLLEH--SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGAL---GAKIVNSRDA 856
Query: 238 RGKTPLILAVEKKHL-GLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRG 296
+G+TPL A ++ GL R+L Q E+N TD G+TAL+ A E E L RG
Sbjct: 857 KGRTPLHAAAFADNVSGL--RMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914
Score = 73.6 bits (179), Expect = 6e-13
Identities = 69/215 (32%), Positives = 99/215 (46%), Gaps = 17/215 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGG-WTPLHNAVQMSREDIVELLLRHGADPVLRKKN--GATP 95
D ++ LLE F EG +TPLH AV +++ E+LL ++ ++ G TP
Sbjct: 805 DCLELLLEHSP---FSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861
Query: 96 FILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR 155
AA A +V L++ L A+VN D G TA M AA G+ A++FL RG
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG------- 914
Query: 156 KTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDD 215
K D L + TAL A KGH + ++L E D+ N +AL L +
Sbjct: 915 --KADLTVLDENKNTALHLACSKGHEKCALMILAET-QDLGLI-NATNSALQMPLHIAAR 970
Query: 216 SDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
+ + ++ LL HGA V E G TP + K
Sbjct: 971 NGLASVVQALLSHGATVLAVDEEGHTPALACAPNK 1005
Score = 64.3 bits (155), Expect = 4e-10
Identities = 72/234 (30%), Positives = 104/234 (44%), Gaps = 36/234 (15%)
Query: 75 VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNEC--DFYGFTAFMEA 132
+E LL +GADP LR + G T AA G+ + L+L L + E + A
Sbjct: 533 LEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLA 592
Query: 133 AVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMG 192
A G +ALK L + N+++R G TAL A E+G E +++L G
Sbjct: 593 AYNGHCEALKTLAETLVNLDVRDHK----------GRTALFLATERGSTECVEVLTAH-G 641
Query: 193 ADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHG--ADV-NVRGERGKTPLILAVEK 249
A + + +HA +S +D HLL+D G AD+ +V G+TPL+LA+
Sbjct: 642 ASALIKERKRKWTPLHAAAASGHTD---SLHLLIDSGERADITDVMDAYGQTPLMLAIMN 698
Query: 250 KHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD 303
H+ V LLE+ + D G+TAL RGA T C D
Sbjct: 699 GHVDCVHLLLEKGS-TADAADLRGRTAL----------------HRGAVTGCED 735
>gi|157739945 tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 2 [Homo sapiens]
Length = 1990
Score = 100 bits (250), Expect = 4e-21
Identities = 101/343 (29%), Positives = 155/343 (45%), Gaps = 54/343 (15%)
Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQ--MSREDIVELLLRHGADPVL 87
++ + ++ + + L+ GGAN+N++ E P+ VQ + ++V LLL GA+
Sbjct: 855 LRNLYTPNIKVSRLLILGGANINYRTEVLNNAPIL-CVQSHLGYTEMVALLLEFGANVDA 913
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL--- 144
++G TP AA AG + ++ L K A V+ D G A + AA+ G ++ +KFL
Sbjct: 914 SSESGLTPLGYAAAAGYLSIVVLLCKKRAKVDHLDKNGQCALVHAALRGHLEVVKFLIQC 973
Query: 145 -----------YKRGANV--------------------NLRRKTKEDQERLRKG------ 167
+K+ + +L K +E+ ER +
Sbjct: 974 DWTMAGQQQGVFKKSHAIQQALIAAASMGYTEIVSYLLDLPEKDEEEVERAQINSFDSLW 1033
Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227
G TAL AA +G +EV ++LL E GA V + G L + I LLL
Sbjct: 1034 GETALTAAAGRGKLEVCRLLL-EQGAAVAQPNRRGAVPLFSTVRQGH----WQIVDLLLT 1088
Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKK 287
HGADVN+ ++G+TPL++A + HLG V LL Q I D +G TAL A
Sbjct: 1089 HGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQ-GASIALMDKEGLTALSWACLKGHLS 1147
Query: 288 IAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGA 325
+ L GA+TD D + A D +V+ L+ HGA
Sbjct: 1148 VVRSLVDNGAATDHADKNGRTPLDLAAFYGDAEVVQFLVDHGA 1190
Score = 83.6 bits (205), Expect = 6e-16
Identities = 78/273 (28%), Positives = 120/273 (43%), Gaps = 26/273 (9%)
Query: 49 ANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLL 108
A +N + G T L A + ++ LLL GA + GA P G +++
Sbjct: 1024 AQINSFDSLWGETALTAAAGRGKLEVCRLLLEQGAAVAQPNRRGAVPLFSTVRQGHWQIV 1083
Query: 109 KLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGG 168
L L+ GADVN D G T M AA G + + FL +GA++ L + K G
Sbjct: 1084 DLLLTHGADVNMADKQGRTPLMMAASEGHLGTVDFLLAQGASIAL----------MDKEG 1133
Query: 169 ATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDH 228
TAL A KGH+ V++ L+D GA + D GR L A D + L+DH
Sbjct: 1134 LTALSWACLKGHLSVVRSLVDN-GAATDHADKNGRTPLDLAAFYGD----AEVVQFLVDH 1188
Query: 229 GADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD---SDGKTALLLAVELKL 285
GA + G PL AV ++ +V LL ++ +I + K +++ + KL
Sbjct: 1189 GAMIEHVDYSGMRPLDRAVGCRNTSVVVTLL-KKGAKIGPATWAMATSKPDIMIILLSKL 1247
Query: 286 KKIAELLCKRGASTDCGDLVMTARRNYDHSLVK 318
+ ++ K+G V A + Y ++L K
Sbjct: 1248 MEEGDMFYKKGK-------VKEAAQRYQYALKK 1273
Score = 72.0 bits (175), Expect = 2e-12
Identities = 58/182 (31%), Positives = 83/182 (45%), Gaps = 12/182 (6%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L A +++ + LLE GA V Q G PL + V+ IV+LLL HGAD +
Sbjct: 1038 LTAAAGRGKLEVCRLLLEQGAAVA-QPNRRGAVPLFSTVRQGHWQIVDLLLTHGADVNMA 1096
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
K G TP ++AA G + + L++GA + D G TA A + G + ++ L G
Sbjct: 1097 DKQGRTPLMMAASEGHLGTVDFLLAQGASIALMDKEGLTALSWACLKGHLSVVRSLVDNG 1156
Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIH 208
A + K G T L AA G EV++ L+D GA + D G L
Sbjct: 1157 AAT----------DHADKNGRTPLDLAAFYGDAEVVQFLVDH-GAMIEHVDYSGMRPLDR 1205
Query: 209 AL 210
A+
Sbjct: 1206 AV 1207
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 99.4 bits (246), Expect = 1e-20
Identities = 92/301 (30%), Positives = 139/301 (46%), Gaps = 23/301 (7%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLR 88
L+ A Q++ DL LL GA+ N + +E GW PLH A Q + LLL HGA +
Sbjct: 399 LLIAAQDQQPDLCALLLAHGADAN-RVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQ 457
Query: 89 KKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRG 148
++ G TP LAA + +L +S+ AD N + G T AA +G V +K L +G
Sbjct: 458 EREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQG 517
Query: 149 ANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIH 208
A ++ + Q LR T L A E+G V ++ LL + GA +A D G L
Sbjct: 518 AELDAQ------QRNLR----TPLHLAVERGKVRAIQHLL-KSGAVPDALDQSGYGPLHT 566
Query: 209 ALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEIND 268
A I +LL +GA + + +G TPL LA K HL ++ LL + H +
Sbjct: 567 AAARGK----YLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEII-HLLAESHANMGA 621
Query: 269 TDSDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLS 322
+ T L LA + + L + GA + + L + +R+ S++ +L
Sbjct: 622 LGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEH 681
Query: 323 H 323
H
Sbjct: 682 H 682
Score = 95.1 bits (235), Expect = 2e-19
Identities = 98/312 (31%), Positives = 142/312 (45%), Gaps = 53/312 (16%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A QN D + LL+ GA V+ QE EG WTPLH A Q + E++ LL+ ADP L +
Sbjct: 435 AAQNGDDGTARLLLDHGACVDAQEREG-WTPLHLAAQNNFENVARLLVSRQADPNLHEAE 493
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA-- 149
G TP +AA G V L+KL S+GA+++ T A GKV+A++ L K GA
Sbjct: 494 GKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVP 553
Query: 150 ------------NVNLRRKTKEDQERLRKG---------GATALMDAAEKGHVEVLKILL 188
R K + LR G G T L AA KGH+E++ +L
Sbjct: 554 DALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLA 613
Query: 189 DE---MGA-------DVNACDNMGRNALIHALLS--SDDSDVEAI----THL-------- 224
+ MGA ++ G A++ ALL +D + E HL
Sbjct: 614 ESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFL 673
Query: 225 ----LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLA 280
LL+H A+V+ R + G TP LA K + +++ L+E +++ D T L LA
Sbjct: 674 SVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVE-AGAQLDVQDGVSCTPLQLA 732
Query: 281 VELKLKKIAELL 292
+ + + I L
Sbjct: 733 LRSRKQGIMSFL 744
Score = 72.8 bits (177), Expect = 1e-12
Identities = 74/254 (29%), Positives = 113/254 (44%), Gaps = 22/254 (8%)
Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149
+N TP GSV+ ++L L+ DV+ G+T + AA + L GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209
+ N R+ + G L AA+ G ++LLD GA V+A + G L A
Sbjct: 420 DAN----------RVDEDGWAPLHFAAQNGDDGTARLLLDH-GACVDAQEREGWTPLHLA 468
Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269
++ E + LL+ AD N+ GKTPL +A H+ LV +LL + E++
Sbjct: 469 A----QNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLV-KLLTSQGAELDAQ 523
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHG 324
+ +T L LAVE + + L K GA D D + TA + + K+LL +G
Sbjct: 524 QRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYG 583
Query: 325 AKEDFHPPAEDWKP 338
A + P + W P
Sbjct: 584 ASLEL-PTHQGWTP 596
Score = 70.5 bits (171), Expect = 5e-12
Identities = 72/240 (30%), Positives = 103/240 (42%), Gaps = 16/240 (6%)
Query: 61 TPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNE 120
TPLH V + V LLL H D + +G TP ++AA L L L+ GAD N
Sbjct: 364 TPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 121 CDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGH 180
D G+ AA G + L GA V + QER G T L AA+
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACV-------DAQER---EGWTPLHLAAQNNF 473
Query: 181 VEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240
V ++L+ AD N + G+ L A S + LL GA+++ + +
Sbjct: 474 ENVARLLVSRQ-ADPNLHEAEGKTPLHVAAYFGHVS----LVKLLTSQGAELDAQQRNLR 528
Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTD 300
TPL LAVE+ + +Q LL+ + + D G L A I ++L + GAS +
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVP-DALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/130 (36%), Positives = 64/130 (49%), Gaps = 2/130 (1%)
Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI 74
++ G AV L + A E+ +V LL+ GA+ N E+ GWTPLH AVQ S
Sbjct: 617 ANMGALGAVNWTPLHLAARHGEEA-VVSALLQCGADPN-AAEQSGWTPLHLAVQRSTFLS 674
Query: 75 VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAV 134
V LL H A+ R K G TP LAA+ G+ +LK+ + GA ++ D T A
Sbjct: 675 VINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Query: 135 YGKVKALKFL 144
K + FL
Sbjct: 735 SRKQGIMSFL 744
Score = 30.0 bits (66), Expect = 8.1
Identities = 17/50 (34%), Positives = 25/50 (50%), Gaps = 9/50 (18%)
Query: 469 FKAVQELHLSCGYTHQ--------DLQPQNILIDSKKAAHLADFDKSIKW 510
F+ + E L+ + H DL+P NIL+DS ++DF S KW
Sbjct: 121 FRIIHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLS-KW 169
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 96.3 bits (238), Expect = 9e-20
Identities = 106/362 (29%), Positives = 158/362 (43%), Gaps = 78/362 (21%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA----- 83
L A Q +++V+ LLE GAN N E+ G+TPL A+Q E++V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 84 ------------------------DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119
+P + K G TP +AA ++ + +L L++GA VN
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179
G T A+ G V ++ L RGA + KTK++ T L AA G
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDE--------LTPLHCAARNG 283
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHA----------LLSSDDSDVEAIT--HL--- 224
HV + +ILLD GA + A G + + A LL D++++ IT HL
Sbjct: 284 HVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 225 --------------LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270
LLD GA N R G TPL +A +K H+ +++ LL + I+
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVT 401
Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHG 324
G T L +A + I + L +RGAS + + L M AR + + K LL +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT-EVAKYLLQNK 460
Query: 325 AK 326
AK
Sbjct: 461 AK 462
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/255 (32%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
V + + LLE A+ N + G TPLH AV + DIV+LLL G P NG TP
Sbjct: 549 VRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA V++ + L G N G T AA G + + L + AN NL K+
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
G T L A++GHV V +L+ G V+A MG L ++S +
Sbjct: 668 ----------GLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLH---VASHYGN 713
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
++ + LL H ADVN + + G +PL A ++ H +V LL + N+ SDG T L
Sbjct: 714 IKLVK-FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Query: 278 LLAVELKLKKIAELL 292
+A L + ++L
Sbjct: 772 AIAKRLGYISVTDVL 786
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/292 (29%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
++ + LL+ A VN + ++ TPLH A ++ ++V+LLL + A+P L G TP +
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
AA G V+ + L K A GFT AA YGKV+ + L +R A+ N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN------ 563
Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
K G T L A +++++K+LL G+ + N +++ + V
Sbjct: 564 ----AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP----HSPAWNGYTPLHIAAKQNQV 615
Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278
E + LL +G N +G TPL LA ++ H +V LL ++ N + G T L
Sbjct: 616 E-VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLH 673
Query: 279 LAVELKLKKIAELLCKRG----ASTDCGDLVMTARRNYDH-SLVKVLLSHGA 325
L + +A++L K G A+T G + +Y + LVK LL H A
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 94.4 bits (233), Expect = 3e-19
Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 24/307 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A Q + +D V+ LL+ A ++ + TPLH A + ++LL GA P R N
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A V++++L L GA ++ G T A+ G + +K L +RGA+
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N+ E T L AA GH EV K LL A VNA + L A
Sbjct: 431 NVSNVKVE----------TPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQTPLHCAAR 479
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V+ LLL++ A+ N+ G TPL +A + H+ V LLE+E + T
Sbjct: 480 IGHTNMVK----LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-K 534
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
G T L +A + ++AELL +R A + + A + + +VK+LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 327 EDFHPPA 333
H PA
Sbjct: 595 P--HSPA 599
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 13/179 (7%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A QN+ V++ + LL+ G + N + +G TPLH A Q ++V LLL A+ L
Sbjct: 606 LHIAAKQNQ-VEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP L A G V + + + G V+ G+T A+ YG +K +KFL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
A+VN + K G + L AA++GH +++ +LL + GA N + G L
Sbjct: 724 QADVNAKTKL----------GYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/324 (25%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118
G T LH A ++++V L+ +GA+ + + G TP +AA ++++K L GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR-----KTKEDQER---------- 163
N GFT A G + L G +R + D R
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 164 ----LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG----------RNALIHA 209
L K G T L AA ++ V ++LL+ GA VN G N ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 210 LLSSDDSDVEA-------------------ITHLLLDHGADVNVRGERGKTPLILAVEKK 250
LL + +E I+ +LLDHGA + + + G +P+ +A +
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDL 304
HL V RLL Q EI+D D T L +A ++A++L +GA + L
Sbjct: 317 HLDCV-RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 305 VMTARRNYDHSLVKVLLSHGAKED 328
+ ++N+ ++++LL GA D
Sbjct: 376 HIACKKNHVR-VMELLLKTGASID 398
Score = 77.8 bits (190), Expect = 3e-14
Identities = 81/301 (26%), Positives = 133/301 (44%), Gaps = 26/301 (8%)
Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK 89
++A ++ ++D L G ++N + G LH A + +V LL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNG-LNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149
K G T +AA+AG ++++ ++ GA+VN GFT AA ++ +KFL + GA
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209
N N+ ED G T L A ++GH V+ L++ R +H
Sbjct: 136 NQNV---ATED-------GFTPLAVALQQGHENVVAHLIN------YGTKGKVRLPALHI 179
Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269
+DD+ A+ LL + + +V + G TPL +A ++L + Q LL + +N T
Sbjct: 180 AARNDDTRTAAV---LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFT 235
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHG 324
+G T L +A + LL RGA + + A RN + ++LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 325 A 325
A
Sbjct: 296 A 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/273 (28%), Positives = 124/273 (45%), Gaps = 50/273 (18%)
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVK-ALKFLYK 146
R+ + AT F+ AA +G++ L G D+N C+ G A+ G VK ++ L+K
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
+ L TK+ G TAL AA G EV++ L++ GA+VNA G L
Sbjct: 68 ---EIILETTTKK--------GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPL 115
Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL-------- 258
+++ ++ +E + LL++GA+ NV E G TPL +A+++ H +V L
Sbjct: 116 ---YMAAQENHLE-VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 259 --LEQEHIEINDTDS------------------DGKTALLLAVELKLKKIAELLCKRGAS 298
L HI + D+ G T L +A + +A+LL RGAS
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 299 TDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
+ + A R + +V++LL GA+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 4/127 (3%)
Query: 18 GRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVEL 77
G ++ + HL+ Q V + L++ G V+ G +TPLH A +V+
Sbjct: 664 GNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKF 719
Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
LL+H AD + K G +P AA G ++ L L GA NE G T A G
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 138 VKALKFL 144
+ L
Sbjct: 780 ISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 96.3 bits (238), Expect = 9e-20
Identities = 106/362 (29%), Positives = 158/362 (43%), Gaps = 78/362 (21%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA----- 83
L A Q +++V+ LLE GAN N E+ G+TPL A+Q E++V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 84 ------------------------DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119
+P + K G TP +AA ++ + +L L++GA VN
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179
G T A+ G V ++ L RGA + KTK++ T L AA G
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDE--------LTPLHCAARNG 283
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHA----------LLSSDDSDVEAIT--HL--- 224
HV + +ILLD GA + A G + + A LL D++++ IT HL
Sbjct: 284 HVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 225 --------------LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270
LLD GA N R G TPL +A +K H+ +++ LL + I+
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVT 401
Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHG 324
G T L +A + I + L +RGAS + + L M AR + + K LL +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT-EVAKYLLQNK 460
Query: 325 AK 326
AK
Sbjct: 461 AK 462
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/255 (32%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
V + + LLE A+ N + G TPLH AV + DIV+LLL G P NG TP
Sbjct: 549 VRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA V++ + L G N G T AA G + + L + AN NL K+
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
G T L A++GHV V +L+ G V+A MG L ++S +
Sbjct: 668 ----------GLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLH---VASHYGN 713
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
++ + LL H ADVN + + G +PL A ++ H +V LL + N+ SDG T L
Sbjct: 714 IKLVK-FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Query: 278 LLAVELKLKKIAELL 292
+A L + ++L
Sbjct: 772 AIAKRLGYISVTDVL 786
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/292 (29%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
++ + LL+ A VN + ++ TPLH A ++ ++V+LLL + A+P L G TP +
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
AA G V+ + L K A GFT AA YGKV+ + L +R A+ N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN------ 563
Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
K G T L A +++++K+LL G+ + N +++ + V
Sbjct: 564 ----AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP----HSPAWNGYTPLHIAAKQNQV 615
Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278
E + LL +G N +G TPL LA ++ H +V LL ++ N + G T L
Sbjct: 616 E-VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLH 673
Query: 279 LAVELKLKKIAELLCKRG----ASTDCGDLVMTARRNYDH-SLVKVLLSHGA 325
L + +A++L K G A+T G + +Y + LVK LL H A
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 94.4 bits (233), Expect = 3e-19
Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 24/307 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A Q + +D V+ LL+ A ++ + TPLH A + ++LL GA P R N
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A V++++L L GA ++ G T A+ G + +K L +RGA+
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N+ E T L AA GH EV K LL A VNA + L A
Sbjct: 431 NVSNVKVE----------TPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQTPLHCAAR 479
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V+ LLL++ A+ N+ G TPL +A + H+ V LLE+E + T
Sbjct: 480 IGHTNMVK----LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-K 534
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
G T L +A + ++AELL +R A + + A + + +VK+LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 327 EDFHPPA 333
H PA
Sbjct: 595 P--HSPA 599
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 13/179 (7%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A QN+ V++ + LL+ G + N + +G TPLH A Q ++V LLL A+ L
Sbjct: 606 LHIAAKQNQ-VEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP L A G V + + + G V+ G+T A+ YG +K +KFL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
A+VN + K G + L AA++GH +++ +LL + GA N + G L
Sbjct: 724 QADVNAKTKL----------GYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/324 (25%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118
G T LH A ++++V L+ +GA+ + + G TP +AA ++++K L GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR-----KTKEDQER---------- 163
N GFT A G + L G +R + D R
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 164 ----LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG----------RNALIHA 209
L K G T L AA ++ V ++LL+ GA VN G N ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 210 LLSSDDSDVEA-------------------ITHLLLDHGADVNVRGERGKTPLILAVEKK 250
LL + +E I+ +LLDHGA + + + G +P+ +A +
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDL 304
HL V RLL Q EI+D D T L +A ++A++L +GA + L
Sbjct: 317 HLDCV-RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 305 VMTARRNYDHSLVKVLLSHGAKED 328
+ ++N+ ++++LL GA D
Sbjct: 376 HIACKKNHVR-VMELLLKTGASID 398
Score = 77.8 bits (190), Expect = 3e-14
Identities = 81/301 (26%), Positives = 133/301 (44%), Gaps = 26/301 (8%)
Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK 89
++A ++ ++D L G ++N + G LH A + +V LL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNG-LNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149
K G T +AA+AG ++++ ++ GA+VN GFT AA ++ +KFL + GA
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209
N N+ ED G T L A ++GH V+ L++ R +H
Sbjct: 136 NQNV---ATED-------GFTPLAVALQQGHENVVAHLIN------YGTKGKVRLPALHI 179
Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269
+DD+ A+ LL + + +V + G TPL +A ++L + Q LL + +N T
Sbjct: 180 AARNDDTRTAAV---LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFT 235
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHG 324
+G T L +A + LL RGA + + A RN + ++LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 325 A 325
A
Sbjct: 296 A 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/273 (28%), Positives = 124/273 (45%), Gaps = 50/273 (18%)
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVK-ALKFLYK 146
R+ + AT F+ AA +G++ L G D+N C+ G A+ G VK ++ L+K
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
+ L TK+ G TAL AA G EV++ L++ GA+VNA G L
Sbjct: 68 ---EIILETTTKK--------GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPL 115
Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL-------- 258
+++ ++ +E + LL++GA+ NV E G TPL +A+++ H +V L
Sbjct: 116 ---YMAAQENHLE-VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 259 --LEQEHIEINDTDS------------------DGKTALLLAVELKLKKIAELLCKRGAS 298
L HI + D+ G T L +A + +A+LL RGAS
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 299 TDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
+ + A R + +V++LL GA+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 4/127 (3%)
Query: 18 GRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVEL 77
G ++ + HL+ Q V + L++ G V+ G +TPLH A +V+
Sbjct: 664 GNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKF 719
Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
LL+H AD + K G +P AA G ++ L L GA NE G T A G
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 138 VKALKFL 144
+ L
Sbjct: 780 ISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 96.3 bits (238), Expect = 9e-20
Identities = 106/362 (29%), Positives = 158/362 (43%), Gaps = 78/362 (21%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA----- 83
L A Q +++V+ LLE GAN N E+ G+TPL A+Q E++V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 84 ------------------------DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119
+P + K G TP +AA ++ + +L L++GA VN
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179
G T A+ G V ++ L RGA + KTK++ T L AA G
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDE--------LTPLHCAARNG 283
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHA----------LLSSDDSDVEAIT--HL--- 224
HV + +ILLD GA + A G + + A LL D++++ IT HL
Sbjct: 284 HVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 225 --------------LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270
LLD GA N R G TPL +A +K H+ +++ LL + I+
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVT 401
Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHG 324
G T L +A + I + L +RGAS + + L M AR + + K LL +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT-EVAKYLLQNK 460
Query: 325 AK 326
AK
Sbjct: 461 AK 462
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/255 (32%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
V + + LLE A+ N + G TPLH AV + DIV+LLL G P NG TP
Sbjct: 549 VRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA V++ + L G N G T AA G + + L + AN NL K+
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
G T L A++GHV V +L+ G V+A MG L ++S +
Sbjct: 668 ----------GLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLH---VASHYGN 713
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
++ + LL H ADVN + + G +PL A ++ H +V LL + N+ SDG T L
Sbjct: 714 IKLVK-FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Query: 278 LLAVELKLKKIAELL 292
+A L + ++L
Sbjct: 772 AIAKRLGYISVTDVL 786
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/292 (29%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
++ + LL+ A VN + ++ TPLH A ++ ++V+LLL + A+P L G TP +
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
AA G V+ + L K A GFT AA YGKV+ + L +R A+ N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN------ 563
Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
K G T L A +++++K+LL G+ + N +++ + V
Sbjct: 564 ----AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP----HSPAWNGYTPLHIAAKQNQV 615
Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278
E + LL +G N +G TPL LA ++ H +V LL ++ N + G T L
Sbjct: 616 E-VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLH 673
Query: 279 LAVELKLKKIAELLCKRG----ASTDCGDLVMTARRNYDH-SLVKVLLSHGA 325
L + +A++L K G A+T G + +Y + LVK LL H A
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 94.4 bits (233), Expect = 3e-19
Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 24/307 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A Q + +D V+ LL+ A ++ + TPLH A + ++LL GA P R N
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A V++++L L GA ++ G T A+ G + +K L +RGA+
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N+ E T L AA GH EV K LL A VNA + L A
Sbjct: 431 NVSNVKVE----------TPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQTPLHCAAR 479
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V+ LLL++ A+ N+ G TPL +A + H+ V LLE+E + T
Sbjct: 480 IGHTNMVK----LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-K 534
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
G T L +A + ++AELL +R A + + A + + +VK+LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 327 EDFHPPA 333
H PA
Sbjct: 595 P--HSPA 599
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 13/179 (7%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A QN+ V++ + LL+ G + N + +G TPLH A Q ++V LLL A+ L
Sbjct: 606 LHIAAKQNQ-VEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP L A G V + + + G V+ G+T A+ YG +K +KFL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
A+VN + K G + L AA++GH +++ +LL + GA N + G L
Sbjct: 724 QADVNAKTKL----------GYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/324 (25%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118
G T LH A ++++V L+ +GA+ + + G TP +AA ++++K L GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR-----KTKEDQER---------- 163
N GFT A G + L G +R + D R
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 164 ----LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG----------RNALIHA 209
L K G T L AA ++ V ++LL+ GA VN G N ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 210 LLSSDDSDVEA-------------------ITHLLLDHGADVNVRGERGKTPLILAVEKK 250
LL + +E I+ +LLDHGA + + + G +P+ +A +
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDL 304
HL V RLL Q EI+D D T L +A ++A++L +GA + L
Sbjct: 317 HLDCV-RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 305 VMTARRNYDHSLVKVLLSHGAKED 328
+ ++N+ ++++LL GA D
Sbjct: 376 HIACKKNHVR-VMELLLKTGASID 398
Score = 77.8 bits (190), Expect = 3e-14
Identities = 81/301 (26%), Positives = 133/301 (44%), Gaps = 26/301 (8%)
Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK 89
++A ++ ++D L G ++N + G LH A + +V LL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNG-LNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149
K G T +AA+AG ++++ ++ GA+VN GFT AA ++ +KFL + GA
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209
N N+ ED G T L A ++GH V+ L++ R +H
Sbjct: 136 NQNV---ATED-------GFTPLAVALQQGHENVVAHLIN------YGTKGKVRLPALHI 179
Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269
+DD+ A+ LL + + +V + G TPL +A ++L + Q LL + +N T
Sbjct: 180 AARNDDTRTAAV---LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFT 235
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHG 324
+G T L +A + LL RGA + + A RN + ++LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 325 A 325
A
Sbjct: 296 A 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/273 (28%), Positives = 124/273 (45%), Gaps = 50/273 (18%)
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVK-ALKFLYK 146
R+ + AT F+ AA +G++ L G D+N C+ G A+ G VK ++ L+K
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
+ L TK+ G TAL AA G EV++ L++ GA+VNA G L
Sbjct: 68 ---EIILETTTKK--------GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPL 115
Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL-------- 258
+++ ++ +E + LL++GA+ NV E G TPL +A+++ H +V L
Sbjct: 116 ---YMAAQENHLE-VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 259 --LEQEHIEINDTDS------------------DGKTALLLAVELKLKKIAELLCKRGAS 298
L HI + D+ G T L +A + +A+LL RGAS
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 299 TDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
+ + A R + +V++LL GA+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 4/127 (3%)
Query: 18 GRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVEL 77
G ++ + HL+ Q V + L++ G V+ G +TPLH A +V+
Sbjct: 664 GNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKF 719
Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
LL+H AD + K G +P AA G ++ L L GA NE G T A G
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 138 VKALKFL 144
+ L
Sbjct: 780 ISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 96.3 bits (238), Expect = 9e-20
Identities = 106/362 (29%), Positives = 158/362 (43%), Gaps = 78/362 (21%)
Query: 29 LIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA----- 83
L A Q +++V+ LLE GAN N E+ G+TPL A+Q E++V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQNVATED-GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 84 ------------------------DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVN 119
+P + K G TP +AA ++ + +L L++GA VN
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 120 ECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKG 179
G T A+ G V ++ L RGA + KTK++ T L AA G
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQI--ETKTKDE--------LTPLHCAARNG 283
Query: 180 HVEVLKILLDEMGADVNACDNMGRNALIHA----------LLSSDDSDVEAIT--HL--- 224
HV + +ILLD GA + A G + + A LL D++++ IT HL
Sbjct: 284 HVRISEILLDH-GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPL 342
Query: 225 --------------LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270
LLD GA N R G TPL +A +K H+ +++ LL + I+
Sbjct: 343 HVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVT 401
Query: 271 SDGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHG 324
G T L +A + I + L +RGAS + + L M AR + + K LL +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT-EVAKYLLQNK 460
Query: 325 AK 326
AK
Sbjct: 461 AK 462
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/255 (32%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
V + + LLE A+ N + G TPLH AV + DIV+LLL G P NG TP
Sbjct: 549 VRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 607
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA V++ + L G N G T AA G + + L + AN NL K+
Sbjct: 608 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 667
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
G T L A++GHV V +L+ G V+A MG L ++S +
Sbjct: 668 ----------GLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLH---VASHYGN 713
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
++ + LL H ADVN + + G +PL A ++ H +V LL + N+ SDG T L
Sbjct: 714 IKLVK-FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Query: 278 LLAVELKLKKIAELL 292
+A L + ++L
Sbjct: 772 AIAKRLGYISVTDVL 786
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/292 (29%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
++ + LL+ A VN + ++ TPLH A ++ ++V+LLL + A+P L G TP +
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 509
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
AA G V+ + L K A GFT AA YGKV+ + L +R A+ N
Sbjct: 510 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN------ 563
Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
K G T L A +++++K+LL G+ + N +++ + V
Sbjct: 564 ----AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP----HSPAWNGYTPLHIAAKQNQV 615
Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278
E + LL +G N +G TPL LA ++ H +V LL ++ N + G T L
Sbjct: 616 E-VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLH 673
Query: 279 LAVELKLKKIAELLCKRG----ASTDCGDLVMTARRNYDH-SLVKVLLSHGA 325
L + +A++L K G A+T G + +Y + LVK LL H A
Sbjct: 674 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 725
Score = 94.4 bits (233), Expect = 3e-19
Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 24/307 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A Q + +D V+ LL+ A ++ + TPLH A + ++LL GA P R N
Sbjct: 312 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 370
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A V++++L L GA ++ G T A+ G + +K L +RGA+
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N+ E T L AA GH EV K LL A VNA + L A
Sbjct: 431 NVSNVKVE----------TPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQTPLHCAAR 479
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V+ LLL++ A+ N+ G TPL +A + H+ V LLE+E + T
Sbjct: 480 IGHTNMVK----LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-K 534
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
G T L +A + ++AELL +R A + + A + + +VK+LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 327 EDFHPPA 333
H PA
Sbjct: 595 P--HSPA 599
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 13/179 (7%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A QN+ V++ + LL+ G + N + +G TPLH A Q ++V LLL A+ L
Sbjct: 606 LHIAAKQNQ-VEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNL 663
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP L A G V + + + G V+ G+T A+ YG +K +KFL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
A+VN + K G + L AA++GH +++ +LL + GA N + G L
Sbjct: 724 QADVNAKTKL----------GYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 771
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/324 (25%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118
G T LH A ++++V L+ +GA+ + + G TP +AA ++++K L GA+
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR-----KTKEDQER---------- 163
N GFT A G + L G +R + D R
Sbjct: 138 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 197
Query: 164 ----LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG----------RNALIHA 209
L K G T L AA ++ V ++LL+ GA VN G N ++
Sbjct: 198 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVR 256
Query: 210 LLSSDDSDVEA-------------------ITHLLLDHGADVNVRGERGKTPLILAVEKK 250
LL + +E I+ +LLDHGA + + + G +P+ +A +
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDL 304
HL V RLL Q EI+D D T L +A ++A++L +GA + L
Sbjct: 317 HLDCV-RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 375
Query: 305 VMTARRNYDHSLVKVLLSHGAKED 328
+ ++N+ ++++LL GA D
Sbjct: 376 HIACKKNHVR-VMELLLKTGASID 398
Score = 77.8 bits (190), Expect = 3e-14
Identities = 81/301 (26%), Positives = 133/301 (44%), Gaps = 26/301 (8%)
Query: 30 IKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRK 89
++A ++ ++D L G ++N + G LH A + +V LL
Sbjct: 17 LRAARSGNLDKALDHLRNGVDINTCNQNG-LNGLHLASKEGHVKMVVELLHKEIILETTT 75
Query: 90 KNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGA 149
K G T +AA+AG ++++ ++ GA+VN GFT AA ++ +KFL + GA
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 150 NVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHA 209
N N+ ED G T L A ++GH V+ L++ R +H
Sbjct: 136 NQNV---ATED-------GFTPLAVALQQGHENVVAHLIN------YGTKGKVRLPALHI 179
Query: 210 LLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDT 269
+DD+ A+ LL + + +V + G TPL +A ++L + Q LL + +N T
Sbjct: 180 AARNDDTRTAAV---LLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFT 235
Query: 270 DSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHG 324
+G T L +A + LL RGA + + A RN + ++LL HG
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295
Query: 325 A 325
A
Sbjct: 296 A 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 77/273 (28%), Positives = 124/273 (45%), Gaps = 50/273 (18%)
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVK-ALKFLYK 146
R+ + AT F+ AA +G++ L G D+N C+ G A+ G VK ++ L+K
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
+ L TK+ G TAL AA G EV++ L++ GA+VNA G L
Sbjct: 68 ---EIILETTTKK--------GNTALHIAALAGQDEVVRELVN-YGANVNAQSQKGFTPL 115
Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRL-------- 258
+++ ++ +E + LL++GA+ NV E G TPL +A+++ H +V L
Sbjct: 116 ---YMAAQENHLE-VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGK 171
Query: 259 --LEQEHIEINDTDS------------------DGKTALLLAVELKLKKIAELLCKRGAS 298
L HI + D+ G T L +A + +A+LL RGAS
Sbjct: 172 VRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGAS 231
Query: 299 TDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
+ + A R + +V++LL GA+
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 4/127 (3%)
Query: 18 GRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVEL 77
G ++ + HL+ Q V + L++ G V+ G +TPLH A +V+
Sbjct: 664 GNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKF 719
Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
LL+H AD + K G +P AA G ++ L L GA NE G T A G
Sbjct: 720 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 779
Query: 138 VKALKFL 144
+ L
Sbjct: 780 ISVTDVL 786
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 95.9 bits (237), Expect = 1e-19
Identities = 82/255 (32%), Positives = 119/255 (46%), Gaps = 17/255 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
V + + LLE A+ N + G TPLH AV + DIV+LLL G P NG TP
Sbjct: 582 VRVAELLLERDAHPN-AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLH 640
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA V++ + L G N G T AA G + + L + AN NL K+
Sbjct: 641 IAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKS 700
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
G T L A++GHV V +L+ G V+A MG L ++S +
Sbjct: 701 ----------GLTPLHLVAQEGHVPVADVLIKH-GVMVDATTRMGYTPLH---VASHYGN 746
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
++ + LL H ADVN + + G +PL A ++ H +V LL + N+ SDG T L
Sbjct: 747 IKLVK-FLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 804
Query: 278 LLAVELKLKKIAELL 292
+A L + ++L
Sbjct: 805 AIAKRLGYISVTDVL 819
Score = 95.5 bits (236), Expect = 2e-19
Identities = 86/292 (29%), Positives = 136/292 (46%), Gaps = 22/292 (7%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
++ + LL+ A VN + ++ TPLH A ++ ++V+LLL + A+P L G TP +
Sbjct: 484 EVAKYLLQNKAKVNAKAKDDQ-TPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHI 542
Query: 99 AAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTK 158
AA G V+ + L K A GFT AA YGKV+ + L +R A+ N
Sbjct: 543 AAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPN------ 596
Query: 159 EDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDV 218
K G T L A +++++K+LL G+ + N +++ + V
Sbjct: 597 ----AAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSP----HSPAWNGYTPLHIAAKQNQV 648
Query: 219 EAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALL 278
E + LL +G N +G TPL LA ++ H +V LL ++ N + G T L
Sbjct: 649 E-VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ-ANGNLGNKSGLTPLH 706
Query: 279 LAVELKLKKIAELLCKRG----ASTDCGDLVMTARRNYDH-SLVKVLLSHGA 325
L + +A++L K G A+T G + +Y + LVK LL H A
Sbjct: 707 LVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA 758
Score = 94.4 bits (233), Expect = 3e-19
Identities = 93/307 (30%), Positives = 139/307 (45%), Gaps = 24/307 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A Q + +D V+ LL+ A ++ + TPLH A + ++LL GA P R N
Sbjct: 345 AAQGDHLDCVRLLLQYDAEIDDITLDH-LTPLHVAAHCGHHRVAKVLLDKGAKPNSRALN 403
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A V++++L L GA ++ G T A+ G + +K L +RGA+
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N+ E T L AA GH EV K LL A VNA + L A
Sbjct: 464 NVSNVKVE----------TPLHMAARAGHTEVAKYLLQNK-AKVNAKAKDDQTPLHCAAR 512
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ V+ LLL++ A+ N+ G TPL +A + H+ V LLE+E + T
Sbjct: 513 IGHTNMVK----LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-K 567
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKVLLSHGAK 326
G T L +A + ++AELL +R A + + A + + +VK+LL G
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Query: 327 EDFHPPA 333
H PA
Sbjct: 628 P--HSPA 632
Score = 85.1 bits (209), Expect = 2e-16
Identities = 82/301 (27%), Positives = 140/301 (46%), Gaps = 24/301 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A +N+D LL+ N + + G +TPLH A ++ +LLL GA +N
Sbjct: 213 AARNDDTRTAAVLLQNDPNPDVLSKTG-FTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +A+ G+V +++L L +GA + T AA G V+ + L GA +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
+ K G + + AA+ H++ +++LL + A++ D++ + L +
Sbjct: 332 QAK----------TKNGLSPIHMAAQGDHLDCVRLLL-QYDAEI---DDITLDHLTPLHV 377
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
++ + +LLD GA N R G TPL +A +K H+ +++ LL + I+
Sbjct: 378 AAHCGH-HRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLL-KTGASIDAVTE 435
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTDCGD------LVMTARRNYDHSLVKVLLSHGA 325
G T L +A + I + L +RGAS + + L M AR + + K LL + A
Sbjct: 436 SGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT-EVAKYLLQNKA 494
Query: 326 K 326
K
Sbjct: 495 K 495
Score = 80.5 bits (197), Expect = 5e-15
Identities = 59/179 (32%), Positives = 91/179 (50%), Gaps = 13/179 (7%)
Query: 28 LLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVL 87
L I A QN+ V++ + LL+ G + N + +G TPLH A Q ++V LLL A+ L
Sbjct: 639 LHIAAKQNQ-VEVARSLLQYGGSANAESVQGV-TPLHLAAQEGHAEMVALLLSKQANGNL 696
Query: 88 RKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKR 147
K+G TP L A G V + + + G V+ G+T A+ YG +K +KFL +
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Query: 148 GANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
A+VN + K G + L AA++GH +++ +LL + GA N + G L
Sbjct: 757 QADVNAKTKL----------GYSPLHQAAQQGHTDIVTLLL-KNGASPNEVSSDGTTPL 804
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/315 (26%), Positives = 137/315 (43%), Gaps = 26/315 (8%)
Query: 16 SSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIV 75
S R+ + ++A ++ ++D L G ++N + G LH A + +V
Sbjct: 36 SRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNG-LNGLHLASKEGHVKMV 94
Query: 76 ELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVY 135
LL K G T +AA+AG ++++ ++ GA+VN GFT AA
Sbjct: 95 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 154
Query: 136 GKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADV 195
++ +KFL + GAN N+ ED G T L A ++GH V+ L++
Sbjct: 155 NHLEVVKFLLENGANQNV---ATED-------GFTPLAVALQQGHENVVAHLIN------ 198
Query: 196 NACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLV 255
R +H +DD+ A+ LL + + +V + G TPL +A ++L +
Sbjct: 199 YGTKGKVRLPALHIAARNDDTRTAAV---LLQNDPNPDVLSKTGFTPLHIAAHYENLNVA 255
Query: 256 QRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARR 310
Q LL + +N T +G T L +A + LL RGA + + A R
Sbjct: 256 QLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAAR 314
Query: 311 NYDHSLVKVLLSHGA 325
N + ++LL HGA
Sbjct: 315 NGHVRISEILLDHGA 329
Score = 78.2 bits (191), Expect = 3e-14
Identities = 83/324 (25%), Positives = 135/324 (41%), Gaps = 57/324 (17%)
Query: 59 GWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADV 118
G T LH A ++++V L+ +GA+ + + G TP +AA ++++K L GA+
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 119 NECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRR-----KTKEDQER---------- 163
N GFT A G + L G +R + D R
Sbjct: 171 NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDP 230
Query: 164 ----LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMG----------RNALIHA 209
L K G T L AA ++ V ++LL+ GA VN G N ++
Sbjct: 231 NPDVLSKTGFTPLHIAAHYENLNVAQLLLNR-GASVNFTPQNGITPLHIASRRGNVIMVR 289
Query: 210 LLSSDDSDVEA-------------------ITHLLLDHGADVNVRGERGKTPLILAVEKK 250
LL + +E I+ +LLDHGA + + + G +P+ +A +
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDL 304
HL V RLL Q EI+D D T L +A ++A++L +GA + L
Sbjct: 350 HLDCV-RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL 408
Query: 305 VMTARRNYDHSLVKVLLSHGAKED 328
+ ++N+ ++++LL GA D
Sbjct: 409 HIACKKNHVR-VMELLLKTGASID 431
Score = 46.2 bits (108), Expect = 1e-04
Identities = 37/127 (29%), Positives = 54/127 (42%), Gaps = 4/127 (3%)
Query: 18 GRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVEL 77
G ++ + HL+ Q V + L++ G V+ G +TPLH A +V+
Sbjct: 697 GNKSGLTPLHLV---AQEGHVPVADVLIKHGVMVDATTRMG-YTPLHVASHYGNIKLVKF 752
Query: 78 LLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGK 137
LL+H AD + K G +P AA G ++ L L GA NE G T A G
Sbjct: 753 LLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGY 812
Query: 138 VKALKFL 144
+ L
Sbjct: 813 ISVTDVL 819
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/260 (30%), Positives = 125/260 (48%), Gaps = 17/260 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
VD+ LLE GA + ++G +TPLH A + D+ +LLL+ A KNG TP
Sbjct: 522 VDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 580
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA + K+ L L KGA + G+T AA +++ L GA N+
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI---- 636
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
+ K G T L A+++GH +++ +LLD+ GA+++ G +L H D +
Sbjct: 637 ------VTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSL-HLAAQEDKVN 688
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
V +L HGAD + + G TPLI+A ++ +V LL+Q +N +G T L
Sbjct: 689 V---ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGYTPL 744
Query: 278 LLAVELKLKKIAELLCKRGA 297
A + I +L + GA
Sbjct: 745 HQAAQQGHTHIINVLLQHGA 764
Score = 94.4 bits (233), Expect = 3e-19
Identities = 85/289 (29%), Positives = 146/289 (50%), Gaps = 24/289 (8%)
Query: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAG 103
LL+ AN N + G +TPLH A + +R ++ELL+++GA ++G TP +AA G
Sbjct: 363 LLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 421
Query: 104 SVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER 163
+ ++ L L GA + + G TA AA G+V+ ++ L + GA V+ R + ++
Sbjct: 422 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---- 477
Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
T L A+ G E++++LL M A +A G L +S+ + V+ +
Sbjct: 478 ------TPLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPL---HISAREGQVD-VAS 526
Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
+LL+ GA ++ ++G TPL +A + L V +LL Q + +G T L +A
Sbjct: 527 VLLEAGAAHSLATKKGFTPLHVAAKYGSLD-VAKLLLQRRAAADSAGKNGLTPLHVAAHY 585
Query: 284 KLKKIAELLCKRGASTDC------GDLVMTARRNYDHSLVKVLLSHGAK 326
+K+A LL ++GAS L + A++N + LL++GA+
Sbjct: 586 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAE 633
Score = 93.6 bits (231), Expect = 6e-19
Identities = 78/261 (29%), Positives = 122/261 (46%), Gaps = 17/261 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + +D+ + LL+ A + + G TPLH A + + LLL GA P KN
Sbjct: 549 AAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 607
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +AA +++ L+ GA+ N G T A+ G + L +GAN+
Sbjct: 608 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
++ K+ G T+L AA++ V V I L + GAD +A +G LI A
Sbjct: 668 HMSTKS----------GLTSLHLAAQEDKVNVADI-LTKHGADQDAHTKLGYTPLIVACH 716
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ + + LL GA+VN + + G TPL A ++ H ++ LL Q + N T +
Sbjct: 717 YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTA 771
Query: 272 DGKTALLLAVELKLKKIAELL 292
+G TAL +A L + + L
Sbjct: 772 NGNTALAIAKRLGYISVVDTL 792
Score = 91.3 bits (225), Expect = 3e-18
Identities = 87/314 (27%), Positives = 140/314 (44%), Gaps = 32/314 (10%)
Query: 24 EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGA 83
+ N ++A + ++D V + L+GG ++N + G LH A + +V+ LL G+
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNG-LNALHLAAKEGHVGLVQELLGRGS 67
Query: 84 DPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKF 143
K G T +A++AG +++K+ + +GA++N GFT AA + +K+
Sbjct: 68 SVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKY 127
Query: 144 LYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGR 203
L + GAN Q + G T L A ++GH + + ILL+ N R
Sbjct: 128 LLENGAN----------QSTATEDGFTPLAVALQQGHNQAVAILLE------NDTKGKVR 171
Query: 204 NALIHALLSSDDSDVEAITHLLLDHGAD------VNVRGERGKTPLILAVEKKHLGLVQR 257
+H DD+ A+ L DH AD VN E G TPL +A ++ V
Sbjct: 172 LPALHIAARKDDTKSAALL-LQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVN-VAT 229
Query: 258 LLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDC------GDLVMTARRN 311
LL ++ T +G T L +A + + +LL RG D L AR
Sbjct: 230 LLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSG 289
Query: 312 YDHSLVKVLLSHGA 325
+D +V++LL GA
Sbjct: 290 HD-QVVELLLERGA 302
Score = 89.7 bits (221), Expect = 9e-18
Identities = 89/309 (28%), Positives = 134/309 (43%), Gaps = 28/309 (9%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEE-------EGGWTPLHNAVQMSREDIVELLLRHGAD 84
A + +D LL+ N + Q + E G+TPLH A ++ LLL GA
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 237
Query: 85 PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144
+NG TP +A+ G+ ++KL L +G ++ G T AA G + ++ L
Sbjct: 238 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 297
Query: 145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRN 204
+RGA + R K G + L AA+ HVE +K LL D++ +
Sbjct: 298 LERGAPLLAR----------TKNGLSPLHMAAQGDHVECVKHLLQHKA----PVDDVTLD 343
Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI 264
L AL + +T LLLD A+ N R G TPL +A +K + V LL +
Sbjct: 344 YLT-ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI-KVMELLVKYGA 401
Query: 265 EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKV 319
I G T + +A + I LL + GAS D ++ + A R +V+
Sbjct: 402 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 461
Query: 320 LLSHGAKED 328
LL +GA D
Sbjct: 462 LLRNGALVD 470
Score = 88.2 bits (217), Expect = 3e-17
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 19/269 (7%)
Query: 35 NEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGAT 94
N+ V L+ LLE GA+ + + G+TPLH A + ++ I LL +GA+ + K G T
Sbjct: 587 NQKVALL--LLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 643
Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR 154
P LA+ G ++ L L KGA+++ G T+ AA KV L K GA
Sbjct: 644 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----- 698
Query: 155 RKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSD 214
DQ+ K G T L+ A G+V+++ LL + GA+VNA G L A
Sbjct: 699 -----DQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGH 752
Query: 215 DSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK 274
I ++LL HGA N G T L +A ++ +V L E+ T +
Sbjct: 753 TH----IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE-EVTTTTTTIT 807
Query: 275 TALLLAVELKLKKIAELLCKRGASTDCGD 303
L V + ++ ++ + G T GD
Sbjct: 808 EKHKLNVPETMTEVLDVSDEEGDDTMTGD 836
Score = 87.0 bits (214), Expect = 6e-17
Identities = 77/269 (28%), Positives = 126/269 (46%), Gaps = 17/269 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + + ++V+ LL+ G ++ + +G TPLH A + + +VELLL GA + R KN
Sbjct: 252 ASKRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKN 310
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G +P +AA V+ +K L A V++ TA AA G + K L + AN
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 370
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N R G T L A +K ++V+++L+ + GA + A G + A
Sbjct: 371 NAR----------ALNGFTPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAF 419
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ I LLL +GA +V RG+T L +A + +V+ LL + ++
Sbjct: 420 MGHLN----IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAR 474
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTD 300
+ +T L +A L +I +LL + A D
Sbjct: 475 EEQTPLHIASRLGKTEIVQLLLQHMAHPD 503
Score = 78.6 bits (192), Expect = 2e-14
Identities = 75/284 (26%), Positives = 126/284 (44%), Gaps = 56/284 (19%)
Query: 86 VLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLY 145
+L+K + F+ AA AG++ + +L G D+N C+ G A AA G V ++ L
Sbjct: 4 MLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL 63
Query: 146 KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNA 205
RG++V + K G TAL A+ G EV+K+L+ E GA++NA +N
Sbjct: 64 GRGSSV----------DSATKKGNTALHIASLAGQAEVVKVLVKE-GANINA---QSQNG 109
Query: 206 LIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLE----- 260
+++ ++ ++ + + LL++GA+ + E G TPL +A+++ H V LLE
Sbjct: 110 FTPLYMAAQENHIDVVKY-LLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKG 168
Query: 261 -------------------------------QEHIEINDTDSDGKTALLLAVELKLKKIA 289
Q + +N T G T L +A +A
Sbjct: 169 KVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVA 228
Query: 290 ELLCKRGASTDCG-----DLVMTARRNYDHSLVKVLLSHGAKED 328
LL RGA+ D + A + + ++VK+LL G + D
Sbjct: 229 TLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQID 272
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/260 (30%), Positives = 125/260 (48%), Gaps = 17/260 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
VD+ LLE GA + ++G +TPLH A + D+ +LLL+ A KNG TP
Sbjct: 543 VDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA + K+ L L KGA + G+T AA +++ L GA N+
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI---- 657
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
+ K G T L A+++GH +++ +LLD+ GA+++ G +L H D +
Sbjct: 658 ------VTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSL-HLAAQEDKVN 709
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
V +L HGAD + + G TPLI+A ++ +V LL+Q +N +G T L
Sbjct: 710 V---ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGYTPL 765
Query: 278 LLAVELKLKKIAELLCKRGA 297
A + I +L + GA
Sbjct: 766 HQAAQQGHTHIINVLLQHGA 785
Score = 94.4 bits (233), Expect = 3e-19
Identities = 85/289 (29%), Positives = 146/289 (50%), Gaps = 24/289 (8%)
Query: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAG 103
LL+ AN N + G +TPLH A + +R ++ELL+++GA ++G TP +AA G
Sbjct: 384 LLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 104 SVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER 163
+ ++ L L GA + + G TA AA G+V+ ++ L + GA V+ R + ++
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---- 498
Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
T L A+ G E++++LL M A +A G L +S+ + V+ +
Sbjct: 499 ------TPLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPL---HISAREGQVD-VAS 547
Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
+LL+ GA ++ ++G TPL +A + L V +LL Q + +G T L +A
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLD-VAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
Query: 284 KLKKIAELLCKRGASTDC------GDLVMTARRNYDHSLVKVLLSHGAK 326
+K+A LL ++GAS L + A++N + LL++GA+
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAE 654
Score = 93.6 bits (231), Expect = 6e-19
Identities = 78/261 (29%), Positives = 122/261 (46%), Gaps = 17/261 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + +D+ + LL+ A + + G TPLH A + + LLL GA P KN
Sbjct: 570 AAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +AA +++ L+ GA+ N G T A+ G + L +GAN+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
++ K+ G T+L AA++ V V I L + GAD +A +G LI A
Sbjct: 689 HMSTKS----------GLTSLHLAAQEDKVNVADI-LTKHGADQDAHTKLGYTPLIVACH 737
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ + + LL GA+VN + + G TPL A ++ H ++ LL Q + N T +
Sbjct: 738 YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTA 792
Query: 272 DGKTALLLAVELKLKKIAELL 292
+G TAL +A L + + L
Sbjct: 793 NGNTALAIAKRLGYISVVDTL 813
Score = 92.4 bits (228), Expect = 1e-18
Identities = 90/336 (26%), Positives = 145/336 (43%), Gaps = 32/336 (9%)
Query: 2 ESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWT 61
+ D G + R + N ++A + ++D V + L+GG ++N + G
Sbjct: 8 QKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNG-LN 66
Query: 62 PLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNEC 121
LH A + +V+ LL G+ K G T +A++AG +++K+ + +GA++N
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 122 DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHV 181
GFT AA + +K+L + GAN Q + G T L A ++GH
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGAN----------QSTATEDGFTPLAVALQQGHN 176
Query: 182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD------VNVR 235
+ + ILL+ N R +H DD+ A+ L DH AD VN
Sbjct: 177 QAVAILLE------NDTKGKVRLPALHIAARKDDTKSAALL-LQNDHNADVQSKMMVNRT 229
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
E G TPL +A ++ V LL ++ T +G T L +A + + +LL R
Sbjct: 230 TESGFTPLHIAAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
G D L AR +D +V++LL GA
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGA 323
Score = 89.7 bits (221), Expect = 9e-18
Identities = 89/309 (28%), Positives = 134/309 (43%), Gaps = 28/309 (9%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEE-------EGGWTPLHNAVQMSREDIVELLLRHGAD 84
A + +D LL+ N + Q + E G+TPLH A ++ LLL GA
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
Query: 85 PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144
+NG TP +A+ G+ ++KL L +G ++ G T AA G + ++ L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Query: 145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRN 204
+RGA + R K G + L AA+ HVE +K LL D++ +
Sbjct: 319 LERGAPLLAR----------TKNGLSPLHMAAQGDHVECVKHLLQHKA----PVDDVTLD 364
Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI 264
L AL + +T LLLD A+ N R G TPL +A +K + V LL +
Sbjct: 365 YLT-ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI-KVMELLVKYGA 422
Query: 265 EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKV 319
I G T + +A + I LL + GAS D ++ + A R +V+
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 320 LLSHGAKED 328
LL +GA D
Sbjct: 483 LLRNGALVD 491
Score = 88.2 bits (217), Expect = 3e-17
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 19/269 (7%)
Query: 35 NEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGAT 94
N+ V L+ LLE GA+ + + G+TPLH A + ++ I LL +GA+ + K G T
Sbjct: 608 NQKVALL--LLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR 154
P LA+ G ++ L L KGA+++ G T+ AA KV L K GA
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----- 719
Query: 155 RKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSD 214
DQ+ K G T L+ A G+V+++ LL + GA+VNA G L A
Sbjct: 720 -----DQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 215 DSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK 274
I ++LL HGA N G T L +A ++ +V L E+ T +
Sbjct: 774 TH----IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE-EVTTTTTTIT 828
Query: 275 TALLLAVELKLKKIAELLCKRGASTDCGD 303
L V + ++ ++ + G T GD
Sbjct: 829 EKHKLNVPETMTEVLDVSDEEGDDTMTGD 857
Score = 87.0 bits (214), Expect = 6e-17
Identities = 77/269 (28%), Positives = 126/269 (46%), Gaps = 17/269 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + + ++V+ LL+ G ++ + +G TPLH A + + +VELLL GA + R KN
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G +P +AA V+ +K L A V++ TA AA G + K L + AN
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N R G T L A +K ++V+++L+ + GA + A G + A
Sbjct: 392 NAR----------ALNGFTPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAF 440
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ I LLL +GA +V RG+T L +A + +V+ LL + ++
Sbjct: 441 MGHLN----IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAR 495
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTD 300
+ +T L +A L +I +LL + A D
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 95.1 bits (235), Expect = 2e-19
Identities = 80/260 (30%), Positives = 125/260 (48%), Gaps = 17/260 (6%)
Query: 38 VDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFI 97
VD+ LLE GA + ++G +TPLH A + D+ +LLL+ A KNG TP
Sbjct: 543 VDVASVLLEAGAAHSLATKKG-FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLH 601
Query: 98 LAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKT 157
+AA + K+ L L KGA + G+T AA +++ L GA N+
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNI---- 657
Query: 158 KEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSD 217
+ K G T L A+++GH +++ +LLD+ GA+++ G +L H D +
Sbjct: 658 ------VTKQGVTPLHLASQEGHTDMVTLLLDK-GANIHMSTKSGLTSL-HLAAQEDKVN 709
Query: 218 VEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTAL 277
V +L HGAD + + G TPLI+A ++ +V LL+Q +N +G T L
Sbjct: 710 V---ADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ-GANVNAKTKNGYTPL 765
Query: 278 LLAVELKLKKIAELLCKRGA 297
A + I +L + GA
Sbjct: 766 HQAAQQGHTHIINVLLQHGA 785
Score = 94.4 bits (233), Expect = 3e-19
Identities = 85/289 (29%), Positives = 146/289 (50%), Gaps = 24/289 (8%)
Query: 44 LLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAG 103
LL+ AN N + G +TPLH A + +R ++ELL+++GA ++G TP +AA G
Sbjct: 384 LLDKRANPNARALNG-FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG 442
Query: 104 SVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQER 163
+ ++ L L GA + + G TA AA G+V+ ++ L + GA V+ R + ++
Sbjct: 443 HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQ---- 498
Query: 164 LRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITH 223
T L A+ G E++++LL M A +A G L +S+ + V+ +
Sbjct: 499 ------TPLHIASRLGKTEIVQLLLQHM-AHPDAATTNGYTPL---HISAREGQVD-VAS 547
Query: 224 LLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVEL 283
+LL+ GA ++ ++G TPL +A + L V +LL Q + +G T L +A
Sbjct: 548 VLLEAGAAHSLATKKGFTPLHVAAKYGSLD-VAKLLLQRRAAADSAGKNGLTPLHVAAHY 606
Query: 284 KLKKIAELLCKRGASTDC------GDLVMTARRNYDHSLVKVLLSHGAK 326
+K+A LL ++GAS L + A++N + LL++GA+
Sbjct: 607 DNQKVALLLLEKGASPHATAKNGYTPLHIAAKKN-QMQIASTLLNYGAE 654
Score = 93.6 bits (231), Expect = 6e-19
Identities = 78/261 (29%), Positives = 122/261 (46%), Gaps = 17/261 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + +D+ + LL+ A + + G TPLH A + + LLL GA P KN
Sbjct: 570 AAKYGSLDVAKLLLQRRAAAD-SAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKN 628
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G TP +AA +++ L+ GA+ N G T A+ G + L +GAN+
Sbjct: 629 GYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
++ K+ G T+L AA++ V V I L + GAD +A +G LI A
Sbjct: 689 HMSTKS----------GLTSLHLAAQEDKVNVADI-LTKHGADQDAHTKLGYTPLIVACH 737
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ + + LL GA+VN + + G TPL A ++ H ++ LL Q + N T +
Sbjct: 738 YGN----VKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLL-QHGAKPNATTA 792
Query: 272 DGKTALLLAVELKLKKIAELL 292
+G TAL +A L + + L
Sbjct: 793 NGNTALAIAKRLGYISVVDTL 813
Score = 92.4 bits (228), Expect = 1e-18
Identities = 90/336 (26%), Positives = 145/336 (43%), Gaps = 32/336 (9%)
Query: 2 ESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWT 61
+ D G + R + N ++A + ++D V + L+GG ++N + G
Sbjct: 8 QKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNG-LN 66
Query: 62 PLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNEC 121
LH A + +V+ LL G+ K G T +A++AG +++K+ + +GA++N
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQ 126
Query: 122 DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHV 181
GFT AA + +K+L + GAN Q + G T L A ++GH
Sbjct: 127 SQNGFTPLYMAAQENHIDVVKYLLENGAN----------QSTATEDGFTPLAVALQQGHN 176
Query: 182 EVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGAD------VNVR 235
+ + ILL+ N R +H DD+ A+ L DH AD VN
Sbjct: 177 QAVAILLE------NDTKGKVRLPALHIAARKDDTKSAALL-LQNDHNADVQSKMMVNRT 229
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
E G TPL +A ++ V LL ++ T +G T L +A + + +LL R
Sbjct: 230 TESGFTPLHIAAHYGNVN-VATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR 288
Query: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
G D L AR +D +V++LL GA
Sbjct: 289 GGQIDAKTRDGLTPLHCAARSGHD-QVVELLLERGA 323
Score = 89.7 bits (221), Expect = 9e-18
Identities = 89/309 (28%), Positives = 134/309 (43%), Gaps = 28/309 (9%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEE-------EGGWTPLHNAVQMSREDIVELLLRHGAD 84
A + +D LL+ N + Q + E G+TPLH A ++ LLL GA
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAA 258
Query: 85 PVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFL 144
+NG TP +A+ G+ ++KL L +G ++ G T AA G + ++ L
Sbjct: 259 VDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELL 318
Query: 145 YKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRN 204
+RGA + R K G + L AA+ HVE +K LL D++ +
Sbjct: 319 LERGAPLLAR----------TKNGLSPLHMAAQGDHVECVKHLLQHKA----PVDDVTLD 364
Query: 205 ALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHI 264
L AL + +T LLLD A+ N R G TPL +A +K + V LL +
Sbjct: 365 YLT-ALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRI-KVMELLVKYGA 422
Query: 265 EINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDL-----VMTARRNYDHSLVKV 319
I G T + +A + I LL + GAS D ++ + A R +V+
Sbjct: 423 SIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRC 482
Query: 320 LLSHGAKED 328
LL +GA D
Sbjct: 483 LLRNGALVD 491
Score = 88.2 bits (217), Expect = 3e-17
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 19/269 (7%)
Query: 35 NEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGAT 94
N+ V L+ LLE GA+ + + G+TPLH A + ++ I LL +GA+ + K G T
Sbjct: 608 NQKVALL--LLEKGASPH-ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVT 664
Query: 95 PFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLR 154
P LA+ G ++ L L KGA+++ G T+ AA KV L K GA
Sbjct: 665 PLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGA----- 719
Query: 155 RKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSD 214
DQ+ K G T L+ A G+V+++ LL + GA+VNA G L A
Sbjct: 720 -----DQDAHTKLGYTPLIVACHYGNVKMVNFLL-KQGANVNAKTKNGYTPLHQAAQQGH 773
Query: 215 DSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK 274
I ++LL HGA N G T L +A ++ +V L E+ T +
Sbjct: 774 TH----IINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTE-EVTTTTTTIT 828
Query: 275 TALLLAVELKLKKIAELLCKRGASTDCGD 303
L V + ++ ++ + G T GD
Sbjct: 829 EKHKLNVPETMTEVLDVSDEEGDDTMTGD 857
Score = 87.0 bits (214), Expect = 6e-17
Identities = 77/269 (28%), Positives = 126/269 (46%), Gaps = 17/269 (6%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A + + ++V+ LL+ G ++ + +G TPLH A + + +VELLL GA + R KN
Sbjct: 273 ASKRGNTNMVKLLLDRGGQIDAKTRDG-LTPLHCAARSGHDQVVELLLERGAPLLARTKN 331
Query: 92 GATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANV 151
G +P +AA V+ +K L A V++ TA AA G + K L + AN
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANP 391
Query: 152 NLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALL 211
N R G T L A +K ++V+++L+ + GA + A G + A
Sbjct: 392 NAR----------ALNGFTPLHIACKKNRIKVMELLV-KYGASIQAITESGLTPIHVAAF 440
Query: 212 SSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS 271
+ I LLL +GA +V RG+T L +A + +V+ LL + ++
Sbjct: 441 MGHLN----IVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGAL-VDARAR 495
Query: 272 DGKTALLLAVELKLKKIAELLCKRGASTD 300
+ +T L +A L +I +LL + A D
Sbjct: 496 EEQTPLHIASRLGKTEIVQLLLQHMAHPD 524
>gi|58331117 ankyrin repeat domain 16 isoform c [Homo sapiens]
Length = 304
Score = 93.2 bits (230), Expect = 8e-19
Identities = 69/199 (34%), Positives = 108/199 (54%), Gaps = 16/199 (8%)
Query: 39 DLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFIL 98
D V+ LL GA V+ ++ WTPL A +++ L+ HGA+P+L+ K+G F +
Sbjct: 85 DCVRYLLGRGAAVDCLKK-ADWTPLMMACTRKNLGVIQELVEHGANPLLKNKDGWNSFHI 143
Query: 99 AAIAGSVKLLKLFLS--KGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK 156
A+ G +L+ L+ GA E T AA++G ++A+K L KR
Sbjct: 144 ASREGDPLILQYLLTVCPGAWKTESKIRR-TPLHTAAMHGHLEAVKVLLKR--------- 193
Query: 157 TKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDS 216
+ + + G TALMDA + GH++V ++LLDE GA ++A D++G AL A ++ D
Sbjct: 194 CQYEPDYRDNCGVTALMDAIQCGHIDVARLLLDEHGACLSAEDSLGAQALHRAAVTGQD- 252
Query: 217 DVEAITHLLLDHGADVNVR 235
EAI L+ + G DV+VR
Sbjct: 253 --EAIRFLVSELGVDVDVR 269
Score = 49.7 bits (117), Expect = 1e-05
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 21/188 (11%)
Query: 18 GRRAAVE-----DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSRE 72
GR AAV+ D L+ A +++ ++Q+L+E GAN + ++ GW H A +
Sbjct: 92 GRGAAVDCLKKADWTPLMMACTRKNLGVIQELVEHGANPLLKNKD-GWNSFHIASREGDP 150
Query: 73 DIVELLLR--HGADPVLRKKNGATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAF 129
I++ LL GA K TP AA+ G ++ +K+ L + + + D G TA
Sbjct: 151 LILQYLLTVCPGAWKT-ESKIRRTPLHTAAMHGHLEAVKVLLKRCQYEPDYRDNCGVTAL 209
Query: 130 MEAAVYGKVKALKFLY-KRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILL 188
M+A G + + L + GA ++ GA AL AA G E ++ L+
Sbjct: 210 MDAIQCGHIDVARLLLDEHGACLSAEDSL----------GAQALHRAAVTGQDEAIRFLV 259
Query: 189 DEMGADVN 196
E+G DV+
Sbjct: 260 SELGVDVD 267
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/93 (34%), Positives = 46/93 (49%), Gaps = 4/93 (4%)
Query: 168 GATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLD 227
G T L AA GH +VL L + G D+ A + + L H S D LL
Sbjct: 37 GDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPL-HEAASMGHRDC---VRYLLG 92
Query: 228 HGADVNVRGERGKTPLILAVEKKHLGLVQRLLE 260
GA V+ + TPL++A +K+LG++Q L+E
Sbjct: 93 RGAAVDCLKKADWTPLMMACTRKNLGVIQELVE 125
Score = 38.5 bits (88), Expect = 0.023
Identities = 45/162 (27%), Positives = 75/162 (46%), Gaps = 14/162 (8%)
Query: 131 EAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDE 190
EAA G +++L RGA V+ L+K T LM A + ++ V++ L+ E
Sbjct: 77 EAASMGHRDCVRYLLGRGAAVDC----------LKKADWTPLMMACTRKNLGVIQELV-E 125
Query: 191 MGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKK 250
GA+ + G N+ ++S + D + +LL + +TPL A
Sbjct: 126 HGANPLLKNKDGWNSFH---IASREGDPLILQYLLTVCPGAWKTESKIRRTPLHTAAMHG 182
Query: 251 HLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELL 292
HL V+ LL++ E + D+ G TAL+ A++ +A LL
Sbjct: 183 HLEAVKVLLKRCQYEPDYRDNCGVTALMDAIQCGHIDVARLL 224
Score = 31.6 bits (70), Expect = 2.8
Identities = 27/96 (28%), Positives = 41/96 (42%), Gaps = 7/96 (7%)
Query: 236 GERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
G G T L A H ++ L E ++I T+ D K L A + + L R
Sbjct: 34 GPAGDTLLHCAARHGHRDVLAYLAEAWGMDIEATNRDYKRPLHEAASMGHRDCVRYLLGR 93
Query: 296 GASTDC------GDLVMTARRNYDHSLVKVLLSHGA 325
GA+ DC L+M R + +++ L+ HGA
Sbjct: 94 GAAVDCLKKADWTPLMMACTRK-NLGVIQELVEHGA 128
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 92.8 bits (229), Expect = 1e-18
Identities = 91/301 (30%), Positives = 128/301 (42%), Gaps = 26/301 (8%)
Query: 27 HLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPV 86
HL ++A Q E + LL AN N G TPLH AV+ +VELLL
Sbjct: 443 HLAVEAGQEE---CAKWLLLNNANPNLSNRRGS-TPLHMAVERRVRGVVELLLARKISVN 498
Query: 87 LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYK 146
+ ++ T AA G +L L K A VNE DF G T A +G+ ++ L +
Sbjct: 499 AKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLR 558
Query: 147 RGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNAL 206
RG +V+L+ K L AA +GH+ ++K+L + G VNA GR L
Sbjct: 559 RGVDVSLQ----------GKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPL 608
Query: 207 IHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEI 266
A + +L+D +DVNV +TPL +A E H RLL
Sbjct: 609 HLAAQRGH----YRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTS-TARLLLHRGAGK 663
Query: 267 NDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAK 326
SDG TAL LA +LL + A + AR + + + + +HG
Sbjct: 664 EAMTSDGYTALHLAARNGHLATVKLLVEEKAD-------VLARGPLNQTALHLAAAHGHS 716
Query: 327 E 327
E
Sbjct: 717 E 717
Score = 91.7 bits (226), Expect = 2e-18
Identities = 86/267 (32%), Positives = 125/267 (46%), Gaps = 19/267 (7%)
Query: 32 AVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKN 91
A QN D + LLE A+VN + EG TP+H A Q +E+IV +LLR G D L+ K+
Sbjct: 511 AAQNGDESSTRLLLEKNASVNEVDFEGR-TPMHVACQHGQENIVRILLRRGVDVSLQGKD 569
Query: 92 GATPFILAAIAGSVKLLKLFLSK-GADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGAN 150
P AA G + ++KL + G VN G T AA G + + L ++
Sbjct: 570 AWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSD 629
Query: 151 VNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHAL 210
VN+ + T L AAE GH ++LL GA A + G AL A
Sbjct: 630 VNVCSLLAQ----------TPLHVAAETGHTSTARLLLHR-GAGKEAMTSDGYTALHLAA 678
Query: 211 LSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTD 270
+ + V+ LL++ ADV RG +T L LA H +V+ L+ + I++ D
Sbjct: 679 RNGHLATVK----LLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSADVIDL--FD 732
Query: 271 SDGKTALLLAVELKLKKIAELLCKRGA 297
G +AL LA + + + E L + GA
Sbjct: 733 EQGLSALHLAAQGRHAQTVETLLRHGA 759
>gi|148596917 fibronectin type III and ankyrin repeat domains 1
[Homo sapiens]
Length = 345
Score = 92.4 bits (228), Expect = 1e-18
Identities = 75/235 (31%), Positives = 121/235 (51%), Gaps = 17/235 (7%)
Query: 63 LHNAVQMSREDIVELLLRHGADPV-LRKKNGATPFILAAIAGSVKLLKLFLSKGADVNEC 121
LH AV ++ ED++ +L+ G V + K G T ++AA G +L+K+ +S G DVN
Sbjct: 114 LHRAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLK 173
Query: 122 DFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHV 181
+ G + M A G + +K+L + GA+ R GG TAL AA+ GH
Sbjct: 174 NGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDL----------GGCTALHWAADGGHC 223
Query: 182 EVLKILLDEMGADVNACDN-MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGK 240
V++ ++ + G +V+ D G L+ S + + + LL+D GA+VNV+ GK
Sbjct: 224 SVIEWMIKD-GCEVDVVDTGSGWTPLMRVSAVSGN---QRVASLLIDAGANVNVKDRNGK 279
Query: 241 TPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKR 295
TPL++AV H LVQ LL+ + + + + GK L +A + + LL +R
Sbjct: 280 TPLMVAVLNNHEELVQLLLD-KGADASVKNEFGKGVLEMARVFDRQSVVSLLEER 333
Score = 84.3 bits (207), Expect = 4e-16
Identities = 71/232 (30%), Positives = 109/232 (46%), Gaps = 14/232 (6%)
Query: 15 SSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI 74
S S R + HL +AV D DL+ ++L+GG + G+T L A Q +
Sbjct: 101 SVSTTREPISSEHLH-RAVSVNDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRL 159
Query: 75 VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAV 134
V++L+ +G D L+ +G +LA AG + ++K GA D G TA AA
Sbjct: 160 VKILVSNGTDVNLKNGSGKDSLMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAAD 219
Query: 135 YGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGAD 194
G ++++ K G V D G + +A G+ V +L+D GA+
Sbjct: 220 GGHCSVIEWMIKDGCEV--------DVVDTGSGWTPLMRVSAVSGNQRVASLLID-AGAN 270
Query: 195 VNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILA 246
VN D G+ L+ A+L++ E + LLLD GAD +V+ E GK L +A
Sbjct: 271 VNVKDRNGKTPLMVAVLNNH----EELVQLLLDKGADASVKNEFGKGVLEMA 318
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,260,667
Number of Sequences: 37866
Number of extensions: 1331600
Number of successful extensions: 8765
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 389
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 4064
Number of HSP's gapped (non-prelim): 2094
length of query: 741
length of database: 18,247,518
effective HSP length: 110
effective length of query: 631
effective length of database: 14,082,258
effective search space: 8885904798
effective search space used: 8885904798
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.