Guide to the Human Genome
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Search of human proteins with 239745895

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo
sapiens]
         (404 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo ...   850   0.0  
gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo ...   850   0.0  
gi|239756892 PREDICTED: hypothetical protein [Homo sapiens]           788   0.0  
gi|48762934 alpha 2 type I collagen [Homo sapiens]                     49   1e-05
gi|209915594 transcription factor 3 isoform E47 [Homo sapiens]         48   2e-05
gi|27777636 transcription factor 3 isoform E12 [Homo sapiens]          47   2e-05
gi|60097902 filaggrin [Homo sapiens]                                   46   5e-05
gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]       46   5e-05
gi|239751449 PREDICTED: hypothetical protein XP_002347867 [Homo ...    46   5e-05
gi|239745954 PREDICTED: hypothetical protein XP_002343623 [Homo ...    46   5e-05
gi|239756937 PREDICTED: hypothetical protein [Homo sapiens]            46   7e-05
gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]      45   9e-05
gi|13489073 egl nine homolog 1 [Homo sapiens]                          45   1e-04
gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]      45   2e-04
gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Hom...    44   2e-04
gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Hom...    44   2e-04
gi|197333868 T-box 2 [Homo sapiens]                                    44   2e-04
gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]            43   4e-04
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       43   6e-04
gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]                43   6e-04
gi|18643383 inositol 1,4,5-trisphosphate 3-kinase C [Homo sapiens]     42   0.001
gi|158854042 hypothetical protein LOC222183 [Homo sapiens]             42   0.001
gi|50843837 hypothetical protein LOC55701 [Homo sapiens]               42   0.001
gi|169168886 PREDICTED: hypothetical protein [Homo sapiens]            41   0.002
gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein ...    41   0.002
gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein ...    41   0.002
gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein ...    41   0.002
gi|23397672 homeobox D4 [Homo sapiens]                                 40   0.003
gi|239751026 PREDICTED: hypothetical protein XP_002347678 [Homo ...    40   0.003
gi|239745455 PREDICTED: hypothetical protein XP_002343496 [Homo ...    40   0.003

>gi|239751388 PREDICTED: hypothetical protein XP_002347834 [Homo
           sapiens]
          Length = 404

 Score =  850 bits (2197), Expect = 0.0
 Identities = 404/404 (100%), Positives = 404/404 (100%)

Query: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60
           MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK
Sbjct: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60

Query: 61  IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120
           IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ
Sbjct: 61  IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120

Query: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180
           VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR
Sbjct: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180

Query: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240
           GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE
Sbjct: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240

Query: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300
           GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR
Sbjct: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300

Query: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360
           RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS
Sbjct: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360

Query: 361 TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH 404
           TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH
Sbjct: 361 TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH 404


>gi|239745895 PREDICTED: hypothetical protein XP_002343612 [Homo
           sapiens]
          Length = 404

 Score =  850 bits (2197), Expect = 0.0
 Identities = 404/404 (100%), Positives = 404/404 (100%)

Query: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60
           MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK
Sbjct: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60

Query: 61  IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120
           IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ
Sbjct: 61  IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120

Query: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180
           VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR
Sbjct: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180

Query: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240
           GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE
Sbjct: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240

Query: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300
           GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR
Sbjct: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300

Query: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360
           RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS
Sbjct: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360

Query: 361 TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH 404
           TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH
Sbjct: 361 TSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHHPPEHRH 404


>gi|239756892 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 576

 Score =  788 bits (2034), Expect = 0.0
 Identities = 377/378 (99%), Positives = 377/378 (99%)

Query: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60
           MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK
Sbjct: 1   MLQNPYAAINTEELVKKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWK 60

Query: 61  IHSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120
           I SLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ
Sbjct: 61  IQSLPYAKGGAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQ 120

Query: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180
           VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR
Sbjct: 121 VAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRR 180

Query: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240
           GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE
Sbjct: 181 GQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDE 240

Query: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300
           GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR
Sbjct: 241 GALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR 300

Query: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360
           RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS
Sbjct: 301 RNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLS 360

Query: 361 TSRDPKSSYTHTHTHTHT 378
           TSRDPKSSYTHTHTHTHT
Sbjct: 361 TSRDPKSSYTHTHTHTHT 378


>gi|48762934 alpha 2 type I collagen [Homo sapiens]
          Length = 1366

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 71/268 (26%), Positives = 92/268 (34%), Gaps = 44/268 (16%)

Query: 114  PPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKG 168
            PP   GQ   +G+   PG     G    P  H P G    H  +G  GPS       A G
Sbjct: 935  PPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVG 994

Query: 169  FRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQ 228
             RG     +  RG      EK PR     +G  G      + GH                
Sbjct: 995  PRGPS-GPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHH--------------- 1038

Query: 229  AALHAVRLDGDEGALQVGHGPAG-RELEGPGGGAAL-GEQRAGATTTPGSRRRRRGAGRS 286
                     GD+GA     GPAG R   GP G A   G      T  P   R  +G    
Sbjct: 1039 ---------GDQGA-PGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGP 1088

Query: 287  AGWPHPGGPSRPTRRNAPPARPDAAGE----QCPRPA-GARPRQAEIETDPETGSDSFST 341
            AG P P GP  P   +         G+      PR A   RP+  E++   ++ ++   T
Sbjct: 1089 AGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIET 1148

Query: 342  WTSYEFNYARPKSHSSPLSTSRDPKSSY 369
              + E       S  +P  T RD + S+
Sbjct: 1149 LLTPE------GSRKNPARTCRDLRLSH 1170



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 66/233 (28%), Positives = 78/233 (33%), Gaps = 38/233 (16%)

Query: 96  RVGRRRGSGARGFSAPCCPPAAGGQVAAR------GKEPKPGGRVTLPALHLPKGVCPHH 149
           R G    +G  G   P  PP  GG  AA+      G  P P G      L  P+G     
Sbjct: 52  RDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMG------LMGPRGP---- 101

Query: 150 PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTA----AGREKHPRAGCSGE-GETGAS 204
           PG   A   +  +G   +     +      RG       AG + HP  G  G  GE G  
Sbjct: 102 PGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHP--GKPGRPGERGVV 159

Query: 205 YPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALG 264
            P+   G      L        H        LDG +G  Q G      E   PG     G
Sbjct: 160 GPQGARGFPGTPGLPGFKGIRGHNG------LDGLKG--QPGAPGVKGEPGAPGENGTPG 211

Query: 265 EQRAGATTTPGSRRR-----RRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
           +   GA   PG R R       GA  S G   P GP+ P     PP  P A G
Sbjct: 212 Q--TGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPG 262



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 68/234 (29%), Positives = 82/234 (35%), Gaps = 33/234 (14%)

Query: 98  GRRRGSGARGFSAPCCPPAAG--GQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSA 155
           G+    G +G   P  P   G  GQ  ARG  P   GRV  P    P G        G  
Sbjct: 190 GQPGAPGVKG--EPGAPGENGTPGQTGARGL-PGERGRVGAPG---PAGARGSDGSVGPV 243

Query: 156 GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPR--AGCSGE-GETGASYPEELHGH 212
           GP+         GF G+       +G+  A     P   AG  GE G  G S P    G+
Sbjct: 244 GPAGPIGSAGPPGFPGAP----GPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGN 299

Query: 213 EAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRA--GA 270
              + L           A  A  L G  GA  +   P  R + GP G A     R   G 
Sbjct: 300 PGANGLT---------GAKGAAGLPGVAGAPGL---PGPRGIPGPVGAAGATGARGLVGE 347

Query: 271 TTTPGSRRR--RRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGAR 322
               GS+     +G   SAG   P GPS    +  P     +AG   P P G R
Sbjct: 348 PGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGP--PGPPGLR 399



 Score = 33.1 bits (74), Expect = 0.46
 Identities = 68/258 (26%), Positives = 80/258 (31%), Gaps = 30/258 (11%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKE--------PKPGGRVTLPALHLPKGVCPHH 149
           G R   G  GF  P  P    G+   +G          P P G         P+GV    
Sbjct: 484 GARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGV---Q 540

Query: 150 PGKGSAGPSRRGRGQRAKGFRG--SEMNSESRRGQTAAGREKHPRAGCSGE----GETGA 203
            GKG  GP      Q   G  G   E+     RG         P AG  GE    GE+GA
Sbjct: 541 GGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGP-AGPRGERGPPGESGA 599

Query: 204 SYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAA 262
           + P    G    S       +      + AV   G  G   +   P  R   G PGG   
Sbjct: 600 AGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGL---PGERGAAGIPGGKGE 656

Query: 263 LGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGAR 322
            GE        PG R      GR      PG    P    A   R +A       PAG R
Sbjct: 657 KGE--------PGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPR 708

Query: 323 PRQAEIETDPETGSDSFS 340
               E       G + F+
Sbjct: 709 GSPGERGEVGPAGPNGFA 726



 Score = 32.7 bits (73), Expect = 0.60
 Identities = 52/231 (22%), Positives = 71/231 (30%), Gaps = 20/231 (8%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGK--- 152
           G R   G  G +    PP   G    +G++  PG  G   LP    P G     PG+   
Sbjct: 517 GARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGK-PGERGL 575

Query: 153 -------GSAGP--SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGA 203
                  G AGP   R   G+         + S    G       K         G  G 
Sbjct: 576 HGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGP 635

Query: 204 SYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAAL 263
           S P  L G    + +     +         +   G +GA     G  G  +  PG   A 
Sbjct: 636 SGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGA----RGAPGA-VGAPGPAGAT 690

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
           G++       P      RG+    G   P GP+          +P A GE+
Sbjct: 691 GDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGER 741



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 53/221 (23%), Positives = 70/221 (31%), Gaps = 53/221 (23%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
           G+R  +G  G + P  PP   G   +RG          LP      GV      +G++GP
Sbjct: 379 GKRGPNGEAGSAGPPGPPGLRGSPGSRG----------LPGADGRAGVMGPPGSRGASGP 428

Query: 158 SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
           +         G RG                   P       GE G   P  L G      
Sbjct: 429 A---------GVRG-------------------PNGDAGRPGEPGLMGPRGLPGSPGN-- 458

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSR 277
               +     +  +    +DG  G +    GPAG   E PG     G +  G T  PG  
Sbjct: 459 ----IGPAGKEGPVGLPGIDGRPGPI----GPAGARGE-PGNIGFPGPK--GPTGDPGKN 507

Query: 278 RRRRGAGRSA--GWPHPGGPSRPTRRNAPPARPDAAGEQCP 316
             +  AG +   G P P G +       P       GEQ P
Sbjct: 508 GDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGP 548



 Score = 28.9 bits (63), Expect = 8.7
 Identities = 25/80 (31%), Positives = 28/80 (35%), Gaps = 2/80 (2%)

Query: 245 VGHGPAGRELEGPGGG-AALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNA 303
           VG GP    L GP G   A G         P       G    AG   P GP      + 
Sbjct: 86  VGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDG 145

Query: 304 PPARPDAAGEQ-CPRPAGAR 322
            P +P   GE+    P GAR
Sbjct: 146 HPGKPGRPGERGVVGPQGAR 165



 Score = 28.9 bits (63), Expect = 8.7
 Identities = 61/240 (25%), Positives = 76/240 (31%), Gaps = 28/240 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGK--EPKPGGRVTLPALHLPKGVCPHHPGKGSA 155
            GR    G  G S P  PP   G+   RG   +  P GR        P G        G A
Sbjct: 793  GRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEA 852

Query: 156  GPSRRGRGQRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGE-GETGASYPEELHGH 212
            G +        +G  G+   +     RG+    R     AG  GE G  G + P    G 
Sbjct: 853  GTAGPPGTPGPQGLLGAPGILGLPGSRGE----RGLPGVAGAVGEPGPLGIAGPPGARGP 908

Query: 213  EAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQ----RA 268
                    A+       A      DG+ G      GP GR+ + PG     G        
Sbjct: 909  PG------AVGSPGVNGAPGEAGRDGNPG----NDGPPGRDGQ-PGHKGERGYPGNIGPV 957

Query: 269  GATTTPGSRRRRRGAGR--SAGWPHPGGPSRPTRRNAP--PARPDAAGEQCPRPAGARPR 324
            GA   PG       AG+  + G   P GP  P     P  P+ P         P    PR
Sbjct: 958  GAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPR 1017


>gi|209915594 transcription factor 3 isoform E47 [Homo sapiens]
          Length = 651

 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 51/190 (26%), Positives = 68/190 (35%), Gaps = 15/190 (7%)

Query: 182 QTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG 241
           Q  AG  + PRAG  G      SY   LHG   +S + + LD+  H    HAV   GD  
Sbjct: 361 QGLAGTSQWPRAGAPGA--LSPSYDGGLHG--LQSKIEDHLDEAIHVLRSHAVGTAGDMH 416

Query: 242 ALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPH-----PGGPS 296
            L  GHG       GP    +LG + AG     G      G   S    H     P  P 
Sbjct: 417 TLLPGHGALASGFTGP---MSLGGRHAGLV---GGSHPEDGLAGSTSLMHNHAALPSQPG 470

Query: 297 RPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHS 356
                + PP      G      A +  ++ E E +  T +   S     E    R ++ S
Sbjct: 471 TLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELKAPRARTSS 530

Query: 357 SPLSTSRDPK 366
           +    S + K
Sbjct: 531 TDEVLSLEEK 540


>gi|27777636 transcription factor 3 isoform E12 [Homo sapiens]
          Length = 654

 Score = 47.4 bits (111), Expect = 2e-05
 Identities = 50/182 (27%), Positives = 66/182 (36%), Gaps = 17/182 (9%)

Query: 182 QTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG 241
           Q  AG  + PRAG  G      SY   LHG   +S + + LD+  H    HAV   GD  
Sbjct: 361 QGLAGTSQWPRAGAPGA--LSPSYDGGLHG--LQSKIEDHLDEAIHVLRSHAVGTAGDMH 416

Query: 242 ALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPH-----PGGPS 296
            L  GHG       GP    +LG + AG     G      G   S    H     P  P 
Sbjct: 417 TLLPGHGALASGFTGP---MSLGGRHAGLV---GGSHPEDGLAGSTSLMHNHAALPSQPG 470

Query: 297 RPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHS 356
                + PP      G      A +  ++ E E +  T +   S     E     P++ +
Sbjct: 471 TLPDLSRPPDSYSGLGRAGATAAASEIKREEKEDEENTSAADHSEEEKKELK--APRART 528

Query: 357 SP 358
           SP
Sbjct: 529 SP 530


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 68/255 (26%), Positives = 88/255 (34%), Gaps = 69/255 (27%)

Query: 153  GSAGPSRRGR-GQRAKGFRGSEMNSESRRGQ-TAAGREKHPRAGCSGEGETGASYPEELH 210
            G AGPS  GR G R +  R S  +S S+ GQ T  G     R G  G      SY E+  
Sbjct: 3725 GRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQG------SYHEQ-- 3776

Query: 211  GHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG----------RELEGPGGG 260
                      ++D   H  + H+      +G     HG +G           E  G G  
Sbjct: 3777 ----------SVDRSGHSGSHHSHTTS--QGRSDASHGQSGSRSASRETRNEEQSGDGSR 3824

Query: 261  AALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAG 320
             +       +T    SR  + G G SAG       SR +RR       D+  E  P    
Sbjct: 3825 HSGSRHHEASTQADSSRHSQSGQGESAG-------SRRSRRQGSSVSQDSDSEAYPE--- 3874

Query: 321  ARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLSTSRD----PKSSYTHTHTHT 376
                      D E  S+S           A    H S    SRD    P SS  H  T +
Sbjct: 3875 ----------DSERRSES-----------ASRNHHGSSREQSRDGSRHPGSS--HRDTAS 3911

Query: 377  HTEPAPVLEFSTPVK 391
            H + +PV   S+  K
Sbjct: 3912 HVQSSPVQSDSSTAK 3926



 Score = 37.0 bits (84), Expect = 0.032
 Identities = 68/298 (22%), Positives = 97/298 (32%), Gaps = 65/298 (21%)

Query: 117  AGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRG----- 171
            A   V   G     G +VT    H            G AGP ++   + A+G  G     
Sbjct: 1378 ASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGR 1437

Query: 172  ---------SEMNSESRRGQTA---AGRE--KHPRAGCSGEGETGASYPEELHGHEAES- 216
                     S   SES  GQTA    GR+  +H +A  S          + + GH   S 
Sbjct: 1438 SRSFLYQVSSHEQSESTHGQTAPSTGGRQGSRHEQARNSSRHSASQDGQDTIRGHPGSSR 1497

Query: 217  ------LLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG----------RELEGPGGG 260
                     +++D   H    H+      +G     HG +G           E  G G  
Sbjct: 1498 GGRQGSYHEQSVDRSGHSGYHHSHTTP--QGRSDASHGQSGPRSASRQTRNEEQSGDGSR 1555

Query: 261  AALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAG 320
             +       +T    SR  + G G SAG       S+ +RR       D           
Sbjct: 1556 HSGSRHHEPSTRAGSSRHSQVGQGESAG-------SKTSRRQGSSVSQD----------- 1597

Query: 321  ARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLSTSRDPKSSYTHTHTHTHT 378
             R  +   E D E  S+S S      +  AR +S       SR+P+S      +H H+
Sbjct: 1598 -RDSEGHSE-DSERRSESAS---RNHYGSAREQSRHG----SRNPRSHQEDRASHGHS 1646



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 50/244 (20%), Positives = 76/244 (31%), Gaps = 52/244 (21%)

Query: 145  VCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREK---HPRAGCSGEGET 201
            V  H   + + G +R   G+R +G    +    SR   +  G++    HP  G S  G  
Sbjct: 3390 VSTHEQSESAHGRTRTSTGRR-QGSHHEQARDSSRHSASQEGQDTIRGHP--GSSRRGRQ 3446

Query: 202  GASYPEELH--GHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGR-----EL 254
            G+ Y + +   GH              H       R D   G  Q G   A R     E 
Sbjct: 3447 GSHYEQSVDRSGHSGSH----------HSHTTSQGRSDASRG--QSGSRSASRQTRNDEQ 3494

Query: 255  EGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
             G G   +       +T    SR  + G G+SAG                          
Sbjct: 3495 SGDGSRHSWSHHHEASTQADSSRHSQSGQGQSAG-------------------------- 3528

Query: 315  CPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHSSPLSTSRDPKSSYTHTHT 374
             PR +  +      ++D +  S+    W+       R  +       SR P S +     
Sbjct: 3529 -PRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSHHEDRAG 3587

Query: 375  HTHT 378
            H H+
Sbjct: 3588 HGHS 3591



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 48/227 (21%), Positives = 78/227 (34%), Gaps = 37/227 (16%)

Query: 153 GSAGPSRRGR-GQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHG 211
           G  GPS   R G   +  R +  +S S+ GQ       HP  G S  G  G+        
Sbjct: 808 GWTGPSTGVRQGSHHEQARDNSRHSASQDGQDTI--RGHP--GSSRRGRQGSH------- 856

Query: 212 HEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGAT 271
           HE      +++D   H  + H+      +G      G +G               R+ + 
Sbjct: 857 HE------QSVDRSGHSGSHHSHTTS--QGRSDASRGQSG--------------SRSASR 894

Query: 272 TTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETD 331
           TT    + R G+  S    H         R++   +  + G +  R  G+   Q   ++D
Sbjct: 895 TTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQ---DSD 951

Query: 332 PETGSDSFSTWTSYEFNYARPKSHSSPLSTSRDPKSSYTHTHTHTHT 378
            E  S+    W+       R  +       SR P+S +     H H+
Sbjct: 952 SEGHSEDSERWSGSASRNHRGSAQEQSRHGSRHPRSHHEDRAGHGHS 998



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 36/142 (25%), Positives = 51/142 (35%), Gaps = 20/142 (14%)

Query: 153  GSAGPSRRGRGQ-RAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELH- 210
            G  GPS  GR + R +  R S  +S S+ GQ       HP  G S  G  G+ Y + +  
Sbjct: 1780 GRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTI--RGHP--GSSRGGRQGSHYEQSVDS 1835

Query: 211  -GHEAESLLLEALDDLAHQAALHAVRLD---GDEGALQVGHGPAGRELEGPGGGAALGEQ 266
             GH              H       R D   G  G+  V       +  G G   +    
Sbjct: 1836 SGHSGSH----------HSHTTSQERSDVSRGQSGSRSVSRQTRNEKQSGDGSRHSGSRH 1885

Query: 267  RAGATTTPGSRRRRRGAGRSAG 288
               ++    SR  + G G+S+G
Sbjct: 1886 HEASSRADSSRHSQVGQGQSSG 1907



 Score = 29.3 bits (64), Expect = 6.6
 Identities = 55/234 (23%), Positives = 77/234 (32%), Gaps = 26/234 (11%)

Query: 149  HPGKGSAGPSRRGRGQRAKGFR--GSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYP 206
            HPG  S    R G G  A   R  G+     S RGQ A+  E+      S  GE   S+ 
Sbjct: 1956 HPG--SHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQ----ARSSAGERHGSH- 2008

Query: 207  EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG--ALQVGHGPAGRELEGPGGGAALG 264
                 H+ +S        + H  A  AVR  G  G    Q        E       +A G
Sbjct: 2009 -----HQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHSEDSDTQSVSAQG 2063

Query: 265  EQRAGATTTPGSRRRRRG--AGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGAR 322
            +      +   S R + G  +GRS  + +       +      + P   G Q     G+ 
Sbjct: 2064 KAGPHQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPSTGGRQ-----GSH 2118

Query: 323  PRQAEIETDPETGSDSFSTWTSY--EFNYARPKSHSSPLSTSRDPKSSYTHTHT 374
              QA+  +      +   T   +       R  SH    S  R   S   H+HT
Sbjct: 2119 YDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQ-SVDRSGHSGSHHSHT 2171


>gi|89276751 alpha 1 type V collagen preproprotein [Homo sapiens]
          Length = 1838

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 65/240 (27%), Positives = 76/240 (31%), Gaps = 23/240 (9%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSA 155
            G R  SGA G   P  PP   G   A G++ +PG  G   LP    P G       KG +
Sbjct: 1255 GPRGPSGAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGES 1314

Query: 156  GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE-GETGASYPEELHGHEA 214
            GPS        KG  G +    S       G    P     GE G  G   P    G + 
Sbjct: 1315 GPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPP-----GEPGPAGQDGPPGDKGDDG 1369

Query: 215  ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE----------LEGPGGGAA-L 263
            E     +                G  G      GP GR+          LEGP G    +
Sbjct: 1370 EPGQTGSPGPTGEPGPSGPPGKRGPPGPA----GPEGRQGEKGAKGEAGLEGPPGKTGPI 1425

Query: 264  GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
            G Q A     P   R   G     G P   GP  P     PP  P   G+  P+     P
Sbjct: 1426 GPQGAPGKPGPDGLRGIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHP 1485



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 59/225 (26%), Positives = 74/225 (32%), Gaps = 44/225 (19%)

Query: 104  GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSAGPSRRG 161
            G RG   P  PP   G     GKE   G  G   LP    P G+      +G  GP    
Sbjct: 1012 GERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGP---- 1067

Query: 162  RGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEA 221
                A G +G+E       G   +  E+ P       G  G   P+   G   E      
Sbjct: 1068 --VGALGLKGNE-GPPGPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEK----- 1119

Query: 222  LDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEGPGG--------GAALGEQRAGATT 272
                            G++G      GPAGR+ L+GP G        G    +   G   
Sbjct: 1120 -------------GAPGEKGP----QGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIG 1162

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR 317
             PG +  +   G   G P P GP  P  +  P     A GE  PR
Sbjct: 1163 EPGQKGSKGDKGEQ-GPPGPTGPQGPIGQPGPSG---ADGEPGPR 1203



 Score = 33.1 bits (74), Expect = 0.46
 Identities = 67/278 (24%), Positives = 90/278 (32%), Gaps = 53/278 (19%)

Query: 104  GARGFSAPCCPPAAGGQVAARGKEPKPG--------GRVTLPALHLPKGVCPHHPGKGSA 155
            G  G   P  PP   G+  A G++   G        G V LP    P G       KG  
Sbjct: 1102 GIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEI 1161

Query: 156  G-PSRRGRGQRAKGFRGSE--------MNSESRRGQTAAGREKHPRAGCSGEGETGASYP 206
            G P ++G    +KG +G +             + G + A  E  PR      G+ G   P
Sbjct: 1162 GEPGQKG----SKGDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGP 1217

Query: 207  EELHGHEAESLLLEALD----DLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGG-- 260
                G     + L+ L     +      +  +   G  G       P     +GP GG  
Sbjct: 1218 RGFPGPPGP-VGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGPPGGIG 1276

Query: 261  --AALGEQ----RAGATTTPGS--------RRRRRGAGRSAGWPHPGGPSRPTRRNAP-- 304
               A+GE+     AG    PG          R  +G    +G   P GP  P   + P  
Sbjct: 1277 NPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKG 1336

Query: 305  -------PARPDAAGEQCPRPAGARPRQAEIETDPETG 335
                   P  P   GE  P PAG      +   D E G
Sbjct: 1337 SPGPVGFPGDPGPPGE--PGPAGQDGPPGDKGDDGEPG 1372



 Score = 32.7 bits (73), Expect = 0.60
 Identities = 60/231 (25%), Positives = 77/231 (33%), Gaps = 34/231 (14%)

Query: 104  GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPG----KGSAGP 157
            G RG   P  P   GG     G    PG  G++ +P L       P +PG    KGS G 
Sbjct: 835  GPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGL-------PGYPGRQGPKGSIGF 887

Query: 158  SRRGRGQRAKGFRGS--EMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAE 215
                     KG RG+  +     +RG T    E+ PR      G  G S  +   G   E
Sbjct: 888  PGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGE 947

Query: 216  SLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEG-PGGGAALGEQ-RAGATT 272
                                  G +G      GP G++ L G PG     G Q + G   
Sbjct: 948  R---------GPNGPQGPTGFPGPKGP----PGPPGKDGLPGHPGQRGETGFQGKTGPPG 994

Query: 273  TPGSRRRRRGAGRSAGWP---HPGGPSRPTRRNAPPARPDAAGEQCPRPAG 320
             PG    +   G +       HPG P  P  +  P        +  P PAG
Sbjct: 995  PPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAG 1045



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 62/249 (24%), Positives = 76/249 (30%), Gaps = 43/249 (17%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
           G++   GA+G   P       G+    GK   PG    +P    P G    HPGK     
Sbjct: 721 GQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPG----MPGADGPPG----HPGKEGPPG 772

Query: 158 SRRGRG----------------QRAKGFRG-----SEMNSESRRGQTAAGREKHPRAGCS 196
            + G+G                + A G RG      E   +   G       K  R    
Sbjct: 773 EKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEKGEDGFPGFKGDMGIKGDRGEIG 832

Query: 197 GEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG 256
             G  G   PE   G    +     L     +  L    L G  G      GP G  +  
Sbjct: 833 PPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGR----QGPKG-SIGF 887

Query: 257 PGGGAALGEQRA-GATTTPGSRRRR--------RGAGRSAGWPHPGGPSRPTRRNAPPAR 307
           PG   A GE+   G    PG R +R        RG     G P P G S       PP  
Sbjct: 888 PGFPGANGEKGGRGTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGE 947

Query: 308 PDAAGEQCP 316
               G Q P
Sbjct: 948 RGPNGPQGP 956



 Score = 30.0 bits (66), Expect = 3.9
 Identities = 56/245 (22%), Positives = 73/245 (29%), Gaps = 46/245 (18%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKE--PKPGGRVTLPALHLPKGVC-----PHHP 150
            G+    G RGF      P   G +  +G E  P P G    P    P G       P  P
Sbjct: 1048 GKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPPGPPGPAGSPGERGPAGAAGPIGIPGRP 1107

Query: 151  G----------------KGSAGPSRRGRGQRAKGFRG-----SEMNSESRRGQTAAGREK 189
            G                KG  GP+ R   Q   G  G          +  +G+     +K
Sbjct: 1108 GPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQK 1167

Query: 190  HPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGP 249
              +     +G  G + P+   G    S    A  +   +         GDEG        
Sbjct: 1168 GSKGDKGEQGPPGPTGPQGPIGQPGPS---GADGEPGPRGQQGLFGQKGDEGP------- 1217

Query: 250  AGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSA--GWPHPGGPSRPTRRNAPPAR 307
              R   GP G   L     G    PG +      G+    G P P GPS     + P   
Sbjct: 1218 --RGFPGPPGPVGL----QGLPGPPGEKGETGDVGQMGPPGPPGPRGPSGAPGADGPQGP 1271

Query: 308  PDAAG 312
            P   G
Sbjct: 1272 PGGIG 1276


>gi|239751449 PREDICTED: hypothetical protein XP_002347867 [Homo
           sapiens]
          Length = 315

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 63/213 (29%), Positives = 85/213 (39%), Gaps = 32/213 (15%)

Query: 119 GQVAARGKEPKPGG---RVTLPALHLPKGVCP---HHPGKGSAGPSRRGRGQRAKGFRGS 172
           G+VA  G  P   G   RV+ P    P+   P   H  G G+ GP  RGR +R +G R  
Sbjct: 41  GEVAPAGGSPLAVGGAFRVSSPRPFPPRPERPSRRHRAGCGAHGPGSRGR-ERRRGSRDP 99

Query: 173 EMNSESR---RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQA 229
                +R   RG++A G    P +G +G      + P      +  +L      +    +
Sbjct: 100 PAGPVARARARGRSAPG-SAQPASGAAGPAAAPEAAPP---AWDPATLPPSRKRNSLGSS 155

Query: 230 ALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRR---RRGAGRS 286
            LH VRL    G ++   GPAG  +       AL     GA      R R   RRG    
Sbjct: 156 PLHPVRL----GRVRAHAGPAGTSILRVAPHPAL----PGAQVHWAGRHRWAARRGKSLQ 207

Query: 287 AGWPHPGG------PSRPTRRNAPPARPDAAGE 313
           + W  PGG      P R T   APP +  A+ E
Sbjct: 208 SAWWGPGGRRNSISPGR-TTFPAPPTQEAASRE 239



 Score = 32.7 bits (73), Expect = 0.60
 Identities = 25/91 (27%), Positives = 35/91 (38%), Gaps = 2/91 (2%)

Query: 274 PGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCP--RPAGARPRQAEIETD 331
           PGSR R R  G       P   +R   R+AP +   A+G   P   P  A P        
Sbjct: 85  PGSRGRERRRGSRDPPAGPVARARARGRSAPGSAQPASGAAGPAAAPEAAPPAWDPATLP 144

Query: 332 PETGSDSFSTWTSYEFNYARPKSHSSPLSTS 362
           P    +S  +   +     R ++H+ P  TS
Sbjct: 145 PSRKRNSLGSSPLHPVRLGRVRAHAGPAGTS 175


>gi|239745954 PREDICTED: hypothetical protein XP_002343623 [Homo
           sapiens]
          Length = 315

 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 63/213 (29%), Positives = 85/213 (39%), Gaps = 32/213 (15%)

Query: 119 GQVAARGKEPKPGG---RVTLPALHLPKGVCP---HHPGKGSAGPSRRGRGQRAKGFRGS 172
           G+VA  G  P   G   RV+ P    P+   P   H  G G+ GP  RGR +R +G R  
Sbjct: 41  GEVAPAGGSPLAVGGAFRVSSPRPFPPRPERPSRRHRAGCGAHGPGSRGR-ERRRGSRDP 99

Query: 173 EMNSESR---RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQA 229
                +R   RG++A G    P +G +G      + P      +  +L      +    +
Sbjct: 100 PAGPVARARARGRSAPG-SAQPASGAAGPAAAPEAAPP---AWDPATLPPSRKRNSLGSS 155

Query: 230 ALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRR---RRGAGRS 286
            LH VRL    G ++   GPAG  +       AL     GA      R R   RRG    
Sbjct: 156 PLHPVRL----GRVRAHAGPAGTSILRVAPHPAL----PGAQVHWAGRHRWAARRGKSLQ 207

Query: 287 AGWPHPGG------PSRPTRRNAPPARPDAAGE 313
           + W  PGG      P R T   APP +  A+ E
Sbjct: 208 SAWWGPGGRRNSISPGR-TTFPAPPTQEAASRE 239



 Score = 32.7 bits (73), Expect = 0.60
 Identities = 25/91 (27%), Positives = 35/91 (38%), Gaps = 2/91 (2%)

Query: 274 PGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCP--RPAGARPRQAEIETD 331
           PGSR R R  G       P   +R   R+AP +   A+G   P   P  A P        
Sbjct: 85  PGSRGRERRRGSRDPPAGPVARARARGRSAPGSAQPASGAAGPAAAPEAAPPAWDPATLP 144

Query: 332 PETGSDSFSTWTSYEFNYARPKSHSSPLSTS 362
           P    +S  +   +     R ++H+ P  TS
Sbjct: 145 PSRKRNSLGSSPLHPVRLGRVRAHAGPAGTS 175


>gi|239756937 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 294

 Score = 45.8 bits (107), Expect = 7e-05
 Identities = 63/213 (29%), Positives = 85/213 (39%), Gaps = 32/213 (15%)

Query: 119 GQVAARGKEPKPGG---RVTLPALHLPKGVCP---HHPGKGSAGPSRRGRGQRAKGFRGS 172
           G+VA  G  P   G   RV+ P    P+   P   H  G G+ GP  RGR +R +G R  
Sbjct: 41  GEVAPAGGSPLAVGGAFRVSSPRPFPPRPERPSRRHRAGCGAHGPGSRGR-ERRRGSRDP 99

Query: 173 EMNSESR---RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQA 229
                +R   RG++A G    P +G +G      + P      +  +L      +    +
Sbjct: 100 PAGPVARARARGRSAPG-SAQPASGAAGPAAAPEAAPP---AWDPATLPPSRKRNSLGSS 155

Query: 230 ALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRR---RRGAGRS 286
            LH VRL    G ++   GPAG  +       AL     GA      R R   RRG    
Sbjct: 156 PLHPVRL----GRVRAHAGPAGPSILRVAPHPAL----PGAQVHWAGRHRWAARRGKSLQ 207

Query: 287 AGWPHPGG------PSRPTRRNAPPARPDAAGE 313
           + W  PGG      P R T   APP +  A+ E
Sbjct: 208 SAWWGPGGRRNSISPGR-TTFPAPPTQEAASRE 239



 Score = 30.4 bits (67), Expect = 3.0
 Identities = 24/91 (26%), Positives = 34/91 (37%), Gaps = 2/91 (2%)

Query: 274 PGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCP--RPAGARPRQAEIETD 331
           PGSR R R  G       P   +R   R+AP +   A+G   P   P  A P        
Sbjct: 85  PGSRGRERRRGSRDPPAGPVARARARGRSAPGSAQPASGAAGPAAAPEAAPPAWDPATLP 144

Query: 332 PETGSDSFSTWTSYEFNYARPKSHSSPLSTS 362
           P    +S  +   +     R ++H+ P   S
Sbjct: 145 PSRKRNSLGSSPLHPVRLGRVRAHAGPAGPS 175


>gi|110349772 alpha 1 type I collagen preproprotein [Homo sapiens]
          Length = 1464

 Score = 45.4 bits (106), Expect = 9e-05
 Identities = 65/229 (28%), Positives = 77/229 (33%), Gaps = 28/229 (12%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSAGPSRRG 161
           G  G + P   P A GQ  A+G    PG  G    P    P G  P  PG G  GP    
Sbjct: 377 GPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSG--PQGPG-GPPGP---- 429

Query: 162 RGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEA 221
                KG  G E  +   +G T A  E  P       G  G        G    + L   
Sbjct: 430 -----KGNSG-EPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGP 483

Query: 222 LDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGG--GAALGEQRAGATTTPGSRR 278
             +     +      DG  G      GPAG R   GP G  G+     R G    PG++ 
Sbjct: 484 PGERGGPGSRGFPGADGVAGP----KGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKG 539

Query: 279 RRRGAGRSA--GWPHPGGPSRPTRRNAPPARPDAAGEQ----CPRPAGA 321
                G     G   P GP+    R  PP  P A G+      P P GA
Sbjct: 540 LTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGA 588



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 58/249 (23%), Positives = 75/249 (30%), Gaps = 24/249 (9%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--------------GRVTLPALHLPK 143
           G    SG  G   P  PP   G     GK  +PG              G   LP +   +
Sbjct: 209 GEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHR 268

Query: 144 GVCPHHPGKGSAGPSRRGRGQRAKGFRGS--EMNSESRRGQTAAGREKHPRAGCSGEGET 201
           G       KG AGP+       + G  G+  +M      G+        P      +G T
Sbjct: 269 GFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGAT 328

Query: 202 GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
           GA+ P    G         A+              +G +G       P      GP G  
Sbjct: 329 GAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNP 388

Query: 262 ALGEQRA--GATTTPGSRRRRR--GAGRSAGWPHPGGPSRPTRRNAPPARP----DAAGE 313
               Q    GA   PG        GA   +G   PGGP  P   +  P  P    D   +
Sbjct: 389 GADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAK 448

Query: 314 QCPRPAGAR 322
             P P G +
Sbjct: 449 GEPGPVGVQ 457



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 69/243 (28%), Positives = 79/243 (32%), Gaps = 32/243 (13%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
            G+R   G  G   P   P   G   A G E  P G +  P L  P G        G+ G 
Sbjct: 965  GQRGERGFPGLPGPSGEPGKQGPSGASG-ERGPPGPMGPPGLAGPPGESGREGAPGAEGS 1023

Query: 158  SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHP--RAGCSGE-GETGASYPEELHGHEA 214
              R     AKG RG E       G   A     P   AG SG+ GETG + P    G   
Sbjct: 1024 PGRDGSPGAKGDRG-ETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVG 1082

Query: 215  ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE----LEGPGGG-AALGEQRAG 269
                          A     R D  E   Q   G  G      L+GP G   + GEQ   
Sbjct: 1083 AR----------GPAGPQGPRGDKGETGEQGDRGIKGHRGFSGLQGPPGPPGSPGEQGPS 1132

Query: 270  ATTTPGSRRRRRGAGRSA------GWPHPGGPSRPTRRN------APPARPDAAGEQCPR 317
              + P   R   G+  +       G P P GP  P  R        PP  P   G   P 
Sbjct: 1133 GASGPAGPRGPPGSAGAPGKDGLNGLPGPIGPPGPRGRTGDAGPVGPPGPPGPPGPPGPP 1192

Query: 318  PAG 320
             AG
Sbjct: 1193 SAG 1195



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 57/233 (24%), Positives = 75/233 (32%), Gaps = 28/233 (12%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
           G     GARG   P   P   G+    G    PG       +  PKG        G AGP
Sbjct: 464 GEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGA----DGVAGPKGPAGERGSPGPAGP 519

Query: 158 SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
               +G   +  R  E      +G T +     P      +G+TG   P    G      
Sbjct: 520 ----KGSPGEAGRPGEAGLPGAKGLTGSPGSPGP------DGKTGPPGPAGQDGRPGPP- 568

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGG--GAALGEQRAGATTTPG 275
                     +     +   G +GA         R + GP G  G A  +  AGA   PG
Sbjct: 569 -----GPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPG 623

Query: 276 -----SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ-CPRPAGAR 322
                  R  +G   S G+    GP+ P      P      G+   P P+GAR
Sbjct: 624 PAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGAR 676



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 64/241 (26%), Positives = 84/241 (34%), Gaps = 32/241 (13%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGK----- 152
           G+   +GA+G      PP   G    RG E  P G      L  P G  P   GK     
Sbjct: 611 GKDGEAGAQG------PPGPAGPAGERG-EQGPAGSPGFQGLPGPAGP-PGEAGKPGEQG 662

Query: 153 -----GSAGPSRRGRGQRA----KGFRGSEMNSESRRGQTAAGRE--KHPRAGCSGEGET 201
                G+ GPS   RG+R     +G +G    +  R    A G +  K         G  
Sbjct: 663 VPGDLGAPGPSG-ARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQ 721

Query: 202 GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
           GA   + + G    + L     D        A    G +G   +  GP G     PG   
Sbjct: 722 GAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLT-GPIGP----PGPAG 776

Query: 262 ALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
           A G++     + P      RGA    G P P GP+          +P A GE  P  AGA
Sbjct: 777 APGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGE--PGDAGA 834

Query: 322 R 322
           +
Sbjct: 835 K 835



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 61/240 (25%), Positives = 77/240 (32%), Gaps = 32/240 (13%)

Query: 104 GARGFSAPCCPPAAGGQVAAR---GKEPKPGGRVTLPALHLPKGV--CPHHPG----KGS 154
           G  G   P  PP  GG  A +   G + K  G +++P    P G    P  PG    +G 
Sbjct: 142 GPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGF 201

Query: 155 AGPSRRGRGQRAKGFRG--------SEMNSESRRGQTAAGREKHPRAGCSGEGETGASYP 206
            GP        A G  G         +   +   G+     E+ P       G  G +  
Sbjct: 202 QGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGL 261

Query: 207 EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQ 266
             + GH   S L  A  D             G+ GA     GP G            GE+
Sbjct: 262 PGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGA-PGQMGPRGLP----------GER 310

Query: 267 RAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR----PAGAR 322
                  P   R   GA  +AG P P GP+ P            AG Q PR    P G R
Sbjct: 311 GRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVR 370



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 63/241 (26%), Positives = 78/241 (32%), Gaps = 24/241 (9%)

Query: 97   VGRRRGSGARGFSAPCCPPAAGGQVAARGK--EPKPGGRVTLPALHLPKGVCPHHPGKGS 154
            +G     GA+G      PP A G   A G+   P P G    P    P G       +G 
Sbjct: 853  IGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGE 912

Query: 155  AGPSRRGRGQRAKGFRG--SEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGH 212
             GP+ R       G  G   E  S    G   A     P+      G  G   P +  G 
Sbjct: 913  TGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVG--LPGQ-RGE 969

Query: 213  EAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGG-----GAALGEQR 267
                 L     +   Q    A    G  G +    GP G  L GP G     GA   E  
Sbjct: 970  RGFPGLPGPSGEPGKQGPSGASGERGPPGPM----GPPG--LAGPPGESGREGAPGAEGS 1023

Query: 268  AGATTTPGSRRRRRGAGRSA-----GWPHPGGPSRPTRRNAPPARPDAAGEQCP-RPAGA 321
             G   +PG++  R   G +      G P   GP  P  ++        AG   P  P GA
Sbjct: 1024 PGRDGSPGAKGDRGETGPAGPPGAPGAPGAPGPVGPAGKSGDRGETGPAGPAGPVGPVGA 1083

Query: 322  R 322
            R
Sbjct: 1084 R 1084



 Score = 29.6 bits (65), Expect = 5.1
 Identities = 64/250 (25%), Positives = 81/250 (32%), Gaps = 22/250 (8%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSAGPSRRG 161
           G RG +    P    G    +G +  PG  G   L     P G       KG +GPS   
Sbjct: 731 GERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPA 790

Query: 162 RGQRAKGFRGSEMNSESRRGQTA----AGREKHPRA----GCSGE-GETGASYPEELHGH 212
               A+G  G        RG+      AG    P A    G  GE G+ GA       G 
Sbjct: 791 GPTGARGAPGD-------RGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGP 843

Query: 213 EAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEGPGGGAALGEQR--AG 269
              +     + ++    A  A    G  GA     G AGR    GP G A        AG
Sbjct: 844 AGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFP-GAAGRVGPPGPSGNAGPPGPPGPAG 902

Query: 270 ATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIE 329
                G R     AGR      PG P     + +P A   A     P P G   ++  + 
Sbjct: 903 KEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVG 962

Query: 330 TDPETGSDSF 339
              + G   F
Sbjct: 963 LPGQRGERGF 972


>gi|13489073 egl nine homolog 1 [Homo sapiens]
          Length = 426

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 44/167 (26%), Positives = 62/167 (37%), Gaps = 15/167 (8%)

Query: 232 HAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPH 291
           H +   G EGAL  GHG    +  GP   AA+   RAGA     +  RR  A        
Sbjct: 54  HKLVCQGSEGAL--GHGVGPHQHSGPAPPAAVPPPRAGAREPRKAAARRDNAS------- 104

Query: 292 PGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYAR 351
            G  ++   +  PPA P AA   C   AG +      E +P  G +     +S    +  
Sbjct: 105 -GDAAKGKVKAKPPADPAAAASPCRAAAGGQGSAVAAEAEP--GKEEPPARSSL---FQE 158

Query: 352 PKSHSSPLSTSRDPKSSYTHTHTHTHTEPAPVLEFSTPVKAICCFHH 398
             +   P +T  D  S       +  T+P P L+ +      C   H
Sbjct: 159 KANLYPPSNTPGDALSPGGGLRPNGQTKPLPALKLALEYIVPCMNKH 205


>gi|4502951 collagen type III alpha 1 preproprotein [Homo sapiens]
          Length = 1466

 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 67/253 (26%), Positives = 84/253 (33%), Gaps = 32/253 (12%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRG 163
           GA+G   P   P + G    RG EP P G         P G+     GKG  GP+     
Sbjct: 348 GAKGEVGPAGSPGSNGAPGQRG-EPGPQGHAGAQGPPGPPGINGSPGGKGEMGPAGIPGA 406

Query: 164 QRAKGFRGSE-----------MNSESRRGQTAAGREKHPRAGCSGE----GETGASYPEE 208
               G RG                    G+  A  E  PR G  GE    G  GA   + 
Sbjct: 407 PGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPR-GERGEAGIPGVPGAKGEDG 465

Query: 209 LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGG--GAALGE 265
             G   E      L   A +      R       +    GPAG R   GP G  GAA   
Sbjct: 466 KDGSPGEPGA-NGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGPRGAAGEP 524

Query: 266 QRAGATTTPGSRRRRRGAGRSAGWP-HPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPR 324
            R G    PG R          G P  PGGP    +   P ++ ++     P P+G R +
Sbjct: 525 GRDGVPGGPGMR----------GMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQ 574

Query: 325 QAEIETDPETGSD 337
              +      G+D
Sbjct: 575 PGVMGFPGPKGND 587



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 62/230 (26%), Positives = 76/230 (33%), Gaps = 38/230 (16%)

Query: 103  SGARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGV--------CPHH 149
            SG RG   P   P   G     G++  PG     GR   P     +G          P H
Sbjct: 989  SGERGPPGPQGLPGLAGTAGEPGRDGNPGSDGLPGRDGSPGGKGDRGENGSPGAPGAPGH 1048

Query: 150  PGK-GSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEE 208
            PG  G  GP+ +  G R +        +    G   A   + PR     +GETG      
Sbjct: 1049 PGPPGPVGPAGKS-GDRGESGPAGPAGAPGPAGSRGAPGPQGPRGD---KGETGERGAAG 1104

Query: 209  LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGG--GAALGE 265
            + GH              +  A  +    G +GA+    GPAG R   GP G  G     
Sbjct: 1105 IKGHRGFP---------GNPGAPGSPGPAGQQGAIG-SPGPAGPRGPVGPSGPPGKDGTS 1154

Query: 266  QRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQC 315
               G    PG R  R   G      HPG P        PP  P A G  C
Sbjct: 1155 GHPGPIGPPGPRGNRGERGSEGSPGHPGQP-------GPPGPPGAPGPCC 1197



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 76/253 (30%), Positives = 90/253 (35%), Gaps = 34/253 (13%)

Query: 97  VGRRRGSGARGFSAPCCPPAAG--GQVAARGKEPKPGGRVTLPALHLPKGVC--PHHPG- 151
           +G R   G RG   P  P AAG  G   ARG + +PG     P    P G    P  PG 
Sbjct: 299 MGPRGAPGERG--RPGLPGAAGARGNDGARGSDGQPGP----PG---PPGTAGFPGSPGA 349

Query: 152 KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHG 211
           KG  GP+       A G RG E   +   G               G+GE G +      G
Sbjct: 350 KGEVGPAGSPGSNGAPGQRG-EPGPQGHAGAQGPPGPPGINGSPGGKGEMGPA------G 402

Query: 212 HEAESLLLEALDDLAHQAALHAVRLDGDEG-----ALQVGHGPAGRELEG--PGGGAALG 264
                 L+ A        A  A  L G  G       +   GP G   E   PG   A G
Sbjct: 403 IPGAPGLMGARGPPGPAGANGAPGLRGGAGEPGKNGAKGEPGPRGERGEAGIPGVPGAKG 462

Query: 265 EQ-RAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ-CPRPAGAR 322
           E  + G+   PG+     GA    G P   GP+ P   N  P     AGE+  P PAG R
Sbjct: 463 EDGKDGSPGEPGA-NGLPGAAGERGAPGFRGPAGP---NGIPGEKGPAGERGAPGPAGPR 518

Query: 323 PRQAEIETDPETG 335
               E   D   G
Sbjct: 519 GAAGEPGRDGVPG 531



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/249 (26%), Positives = 81/249 (32%), Gaps = 46/249 (18%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
            G R   G +G       P A G    RG    P G   LP L    G        GS G 
Sbjct: 966  GPRGSPGPQGVKGESGKPGANGLSGERG----PPGPQGLPGLAGTAGEPGRDGNPGSDGL 1021

Query: 158  SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPR-------AGCSGE-GETGASYPEEL 209
              R      KG RG   +        A G   HP        AG SG+ GE+G + P   
Sbjct: 1022 PGRDGSPGGKGDRGENGSPG------APGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGA 1075

Query: 210  HGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAG 269
             G                          G  GA     GP G + E    GAA  +   G
Sbjct: 1076 PGPA------------------------GSRGA-PGPQGPRGDKGETGERGAAGIKGHRG 1110

Query: 270  ATTTPGSRRRRRGAGRSA--GWPHPGGPSRPTRRNAPPARPDAAGEQCP-RPAGARPRQA 326
                PG+      AG+    G P P GP  P   + PP +   +G   P  P G R  + 
Sbjct: 1111 FPGNPGAPGSPGPAGQQGAIGSPGPAGPRGPVGPSGPPGKDGTSGHPGPIGPPGPRGNRG 1170

Query: 327  EIETDPETG 335
            E  ++   G
Sbjct: 1171 ERGSEGSPG 1179



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 56/226 (24%), Positives = 75/226 (33%), Gaps = 24/226 (10%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRG 163
           G +G   P   P A G + ARG  P P G    P L    G    +  KG  GP    RG
Sbjct: 393 GGKGEMGPAGIPGAPGLMGARGP-PGPAGANGAPGLRGGAGEPGKNGAKGEPGP----RG 447

Query: 164 QRAKGFRGSEMNSESRRGQTAAGREKHPRA--GCSGE----GETGASYPEELHGHEAESL 217
           +R +        ++   G+  +  E       G +GE    G  G + P  + G +  + 
Sbjct: 448 ERGEAGIPGVPGAKGEDGKDGSPGEPGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAG 507

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAAL-------GEQRAGA 270
              A      + A       G+ G   V  GP  R + G  GG          G Q    
Sbjct: 508 ERGAPGPAGPRGAA------GEPGRDGVPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESG 561

Query: 271 TTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCP 316
              P      RG     G+P P G      +N     P   G Q P
Sbjct: 562 RPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQGP 607



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 53/210 (25%), Positives = 64/210 (30%), Gaps = 48/210 (22%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG-KGSAGPSRRGR 162
           G RG + P  PP   GQ   +G+   PG    LP +  P+G     PG +G  GP     
Sbjct: 759 GPRGPTGPIGPPGPAGQPGDKGEGGAPG----LPGIAGPRG----SPGERGETGPPGPAG 810

Query: 163 GQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEAL 222
              A G  G E   +  RG      E  P       G +G + P    G + E       
Sbjct: 811 FPGAPGQNG-EPGGKGERGAPGEKGEGGPPGVAGPPGGSGPAGPPGPQGVKGER------ 863

Query: 223 DDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRG 282
                          G  G       P  R L GP                PGS      
Sbjct: 864 ---------------GSPGGPGAAGFPGARGLPGP----------------PGSNGNPGP 892

Query: 283 AGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
            G S G P   GP  P      P  P  +G
Sbjct: 893 PGPS-GSPGKDGPPGPAGNTGAPGSPGVSG 921



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 68/244 (27%), Positives = 81/244 (33%), Gaps = 53/244 (21%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGK----G 153
           G +  +G RG   P  P  A G+    G++  PGG         P G  P   GK    G
Sbjct: 501 GEKGPAGERGAPGPAGPRGAAGEP---GRDGVPGGPGMRGMPGSPGG--PGSDGKPGPPG 555

Query: 154 SAGPSRRGRGQRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHG 211
           S G S R       G RG    M     +G   A  +   R G  G G  G   P   +G
Sbjct: 556 SQGESGRPGPPGPSGPRGQPGVMGFPGPKGNDGAPGKNGERGGPGGPGPQG---PPGKNG 612

Query: 212 HEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEG-PGGGAALGEQR-- 267
                       +   Q         GD+G      GP G + L+G PG G   GE    
Sbjct: 613 ------------ETGPQGPPGPTGPGGDKGDT----GPPGPQGLQGLPGTGGPPGENGKP 656

Query: 268 --------AGATTTPGSRRR-----RRGAGRSAGWPH------PGGPSRPTRRNAPPARP 308
                   AGA   PG +        RG    AG P       P GP        PP  P
Sbjct: 657 GEPGPKGDAGAPGAPGGKGDAGAPGERGPPGLAGAPGLRGGAGPPGPEGGKGAAGPPGPP 716

Query: 309 DAAG 312
            AAG
Sbjct: 717 GAAG 720



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 50/205 (24%), Positives = 64/205 (31%), Gaps = 19/205 (9%)

Query: 115 PAAGGQVAARGKEPKPGGRVTLPALHLP--KGVCPHHPGKGSAGPSRRGRGQRAKGFRGS 172
           P A G   A G+   PG R       +P  KG        G AGP    RG   +  R  
Sbjct: 473 PGANGLPGAAGERGAPGFRGPAGPNGIPGEKGPAGERGAPGPAGP----RGAAGEPGRDG 528

Query: 173 EMNSESRRGQTAA--GREKHPRAGCSG-EGETGASYPEELHGHEAESLLLEALDDLAHQA 229
                  RG   +  G     + G  G +GE+G   P    G   +  ++       +  
Sbjct: 529 VPGGPGMRGMPGSPGGPGSDGKPGPPGSQGESGRPGPPGPSGPRGQPGVMGFPGPKGN-- 586

Query: 230 ALHAVRLDGDEGALQVGHGPAGRELEGPGG-GAALGEQRAGATTTPGSRRRRRGAGRSAG 288
                  DG  G      GP G   +GP G     G Q     T PG  +   G     G
Sbjct: 587 -------DGAPGKNGERGGPGGPGPQGPPGKNGETGPQGPPGPTGPGGDKGDTGPPGPQG 639

Query: 289 WPHPGGPSRPTRRNAPPARPDAAGE 313
                G   P   N  P  P   G+
Sbjct: 640 LQGLPGTGGPPGENGKPGEPGPKGD 664



 Score = 30.0 bits (66), Expect = 3.9
 Identities = 66/249 (26%), Positives = 77/249 (30%), Gaps = 52/249 (20%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGVCPHHPGK-GSAGP 157
           G  G+  P  PP   G     G    PG     G    P    P G  P  PG  G +GP
Sbjct: 168 GLAGYPGPAGPPGPPGPPGTSGHPGSPGSPGYQGPPGEPGQAGPSGP-PGPPGAIGPSGP 226

Query: 158 S-------RRGR-GQRA-------------------KGFRGSEMNSESRRGQTAAGREKH 190
           +       R GR G+R                    KG RG +      +G+T A   K 
Sbjct: 227 AGKDGESGRPGRPGERGLPGPPGIKGPAGIPGFPGMKGHRGFD-GRNGEKGETGAPGLKG 285

Query: 191 PRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPA 250
                   G  G   P    G      L  A     +  A  +   DG  G      GP 
Sbjct: 286 ENGLPGENGAPGPMGPRGAPGERGRPGLPGAAGARGNDGARGS---DGQPGP----PGPP 338

Query: 251 GRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP---AR 307
           G     PG   A GE   G   +PGS     GA    G P P G +       PP     
Sbjct: 339 G-TAGFPGSPGAKGE--VGPAGSPGS----NGAPGQRGEPGPQGHAGAQGPPGPPGINGS 391

Query: 308 PDAAGEQCP 316
           P   GE  P
Sbjct: 392 PGGKGEMGP 400



 Score = 30.0 bits (66), Expect = 3.9
 Identities = 58/242 (23%), Positives = 77/242 (31%), Gaps = 23/242 (9%)

Query: 103  SGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGR 162
            +G  G S P  PP   G    RG    PG      A  LP G    +   G  GPS    
Sbjct: 842  AGPPGGSGPAGPPGPQGVKGERGSPGGPGAAGFPGARGLP-GPPGSNGNPGPPGPSGSPG 900

Query: 163  GQRAKGFRGS--EMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLE 220
                 G  G+     S    G      +   +     +G  GA  P  + G      L  
Sbjct: 901  KDGPPGPAGNTGAPGSPGVSGPKGDAGQPGEKGSPGAQGPPGAPGPLGIAGITGARGLAG 960

Query: 221  ALDDLAHQAALHAVRLDGDEG-----ALQVGHGPAGRE----LEGPGG-----GAALGEQ 266
                   + +     + G+ G      L    GP G +    L G  G     G    + 
Sbjct: 961  PPGMPGPRGSPGPQGVKGESGKPGANGLSGERGPPGPQGLPGLAGTAGEPGRDGNPGSDG 1020

Query: 267  RAGATTTPGSRRRR-----RGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ-CPRPAG 320
              G   +PG +  R      GA  + G P P GP  P  ++        AG    P PAG
Sbjct: 1021 LPGRDGSPGGKGDRGENGSPGAPGAPGHPGPPGPVGPAGKSGDRGESGPAGPAGAPGPAG 1080

Query: 321  AR 322
            +R
Sbjct: 1081 SR 1082


>gi|111118976 collagen, type II, alpha 1 isoform 1 precursor [Homo
            sapiens]
          Length = 1487

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 70/253 (27%), Positives = 89/253 (35%), Gaps = 38/253 (15%)

Query: 98   GRRRGSGARGFSAP------CCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH 149
            G R   G RG + P        PP A GQ  A+G++ + G  G    P    P G     
Sbjct: 816  GARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQ 875

Query: 150  PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE----GETGASY 205
               G  GP         KG RG++    +     AAGR   P  G +G     G  G S 
Sbjct: 876  GPTGVTGP---------KGARGAQGPPGATGFPGAAGRVGPP--GSNGNPGPPGPPGPSG 924

Query: 206  PEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGE 265
             +   G   +S       +   Q         G+ G      GP+G   EGP G   L  
Sbjct: 925  KDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPG----DDGPSG--AEGPPGPQGLAG 978

Query: 266  QRAGATTTPGSRRRRRGAGRSAGWPHPGGPS-RPTRRNAPPARPDAAGEQCPRPAGARPR 324
            QR G    PG R  R       G+P   GPS  P ++ AP A  D        P G    
Sbjct: 979  QR-GIVGLPGQRGER-------GFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGP 1030

Query: 325  QAEIETDPETGSD 337
              E   +   G+D
Sbjct: 1031 AGEPGREGSPGAD 1043



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 69/246 (28%), Positives = 82/246 (33%), Gaps = 34/246 (13%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGV-----CP 147
            G    SG RG   P  PP   G     G+E  PG     GR     +   +G       P
Sbjct: 1008 GAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAP 1067

Query: 148  HHPG-KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYP 206
              PG  GS GP+     Q  +G  G++       G   A   + P+     +GE G    
Sbjct: 1068 GAPGPPGSPGPAGPTGKQGDRGEAGAQ-GPMGPSGPAGARGIQGPQGPRGDKGEAGEPGE 1126

Query: 207  EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGG--GAALG 264
              L GH   + L         Q         GD+GA     GPAG    GP G  G    
Sbjct: 1127 RGLKGHRGFTGL---------QGLPGPPGPSGDQGA----SGPAGP--SGPRGPPGPVGP 1171

Query: 265  EQRAGATTTPG-----SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPA 319
              + GA   PG       R R G    AG P   GP  P     P     A     PR  
Sbjct: 1172 SGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREK 1231

Query: 320  GARPRQ 325
            G  P Q
Sbjct: 1232 GPDPLQ 1237



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 64/232 (27%), Positives = 76/232 (32%), Gaps = 22/232 (9%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKE--PKPGGRVTLPALHLPKGVCPHH-----P 150
           G R   G  G +    PP   G    RG++  P P G   LP    P G          P
Sbjct: 627 GLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVP 686

Query: 151 GKGSAGPSRRGRGQRA-KGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
           G+  A      RG+R   G RGS      +  RG         P+      G  GA  P 
Sbjct: 687 GEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPP 746

Query: 208 ELHGHEAESLLLEALDDLAHQAALHAVRLD-GDEGALQVGHGPAGRELEGP----GGGAA 262
            L G   E          A  A     R D G++G         GR L GP    G   A
Sbjct: 747 GLQGMPGER-------GAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGA 799

Query: 263 LGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
            GE+       P      RGA    G   P GP+          +P A GEQ
Sbjct: 800 NGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQ 851



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 60/231 (25%), Positives = 74/231 (32%), Gaps = 32/231 (13%)

Query: 96   RVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSA 155
            RVG    +G  G   P  P    G   ARG    P GR   P L  P G        G  
Sbjct: 904  RVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPP-GRAGEPGLQGPAGPPGEKGEPGDD 962

Query: 156  GPSRRGRGQRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHE 213
            GPS        +G  G    +    +RG+        P      +G  GAS      G  
Sbjct: 963  GPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPV 1022

Query: 214  AESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQ-RAGATT 272
                L     +            +G  GA     GP GR+    G     G++   GA  
Sbjct: 1023 GPPGLTGPAGEPGR---------EGSPGA----DGPPGRD----GAAGVKGDRGETGAVG 1065

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR-PAGAR 322
             PG          + G P   GP+ PT +        A G   P  PAGAR
Sbjct: 1066 APG----------APGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGAR 1106



 Score = 36.2 bits (82), Expect = 0.054
 Identities = 62/256 (24%), Positives = 80/256 (31%), Gaps = 39/256 (15%)

Query: 104 GARGFSAPCCPPAAGGQVAAR---GKEPKPGGRVTLPALHLPKG-VCPHHPGKGSAGPSR 159
           G  G   P  PP  GG  AA+   G + K GG   L  +  P G + P  P   +  P  
Sbjct: 162 GPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGG-AQLGVMQGPMGPMGPRGPPGPAGAPGP 220

Query: 160 RG----------------RGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGA 203
           +G                 G R       +   +   G+     E+ P       G  G 
Sbjct: 221 QGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGT 280

Query: 204 SYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAAL 263
                + GH         LD    +A    V+  G+ G+      P      GP G   L
Sbjct: 281 PGLPGVKGHRG----YPGLDGAKGEAGAPGVK--GESGS------PGENGSPGPMGPRGL 328

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR----PA 319
             +R    T P      RG     G   P GP  P      P  P A GE  P     P 
Sbjct: 329 PGERG--RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPE 386

Query: 320 GARPRQAEIETDPETG 335
           GA+  + E  T    G
Sbjct: 387 GAQGPRGEPGTPGSPG 402



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 65/249 (26%), Positives = 79/249 (31%), Gaps = 31/249 (12%)

Query: 96  RVGRRRGSGARGFSA---PCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH- 149
           R G    +GARG      P  PP   G     G    PG  G         P+G      
Sbjct: 334 RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRG 393

Query: 150 -PGK-GSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
            PG  GS GP+         G  G++  S    G   A     PR     +G TG   P+
Sbjct: 394 EPGTPGSPGPAGASGNPGTDGIPGAK-GSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPK 452

Query: 208 ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-----PGGGAA 262
              G             +A        + +      Q   GPAG E +      PGG   
Sbjct: 453 GQTGEPG----------IAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGP 502

Query: 263 LGEQRAGATTTPGSRR--RRRGAGRSAGWPHPGGPSR---PTRRNAPPARPDAAGEQCPR 317
           +G    G    PG+R    + G     G P   GPS    P   N  P RP   G    R
Sbjct: 503 IGPP--GERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGAR 560

Query: 318 PAGARPRQA 326
               RP  A
Sbjct: 561 GLTGRPGDA 569



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 65/234 (27%), Positives = 80/234 (34%), Gaps = 20/234 (8%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGK----GSAG- 156
           G  G   P  PP   G    +G +  PG  G   +     P+G  P  PGK    G AG 
Sbjct: 201 GPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGP-PGPPGKPGDDGEAGK 259

Query: 157 PSRRG-RG----QRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPEEL 209
           P + G RG    Q A+GF G+      +  RG       K        +GE+G+      
Sbjct: 260 PGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGS 319

Query: 210 HGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGH--GPAGRELEGPGGGAALGEQR 267
            G      L           A  A   DG  G        GPAG     PG   A GE  
Sbjct: 320 PGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP-GFPGAPGAKGEAG 378

Query: 268 AGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
                 P   +  RG   + G P P G S     +  P    +AG   P  AGA
Sbjct: 379 PTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAG--APGIAGA 430



 Score = 32.3 bits (72), Expect = 0.78
 Identities = 63/238 (26%), Positives = 73/238 (30%), Gaps = 31/238 (13%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGVCPHHPGKGSAGPS 158
           GARGF      P   G    +G    PG     G    P +    G    +   G  GP 
Sbjct: 273 GARGF------PGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGP- 325

Query: 159 RRGRGQRAKGFRGSEMNSESRRGQTA----------AGREKHPRA-GCSGE-GETGASYP 206
           R   G+R +        +    GQ            AG    P A G  GE G TGA  P
Sbjct: 326 RGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGP 385

Query: 207 EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAALGE 265
           E   G   E              A      DG  GA      P      G PG     G 
Sbjct: 386 EGAQGPRGEP---GTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGP 442

Query: 266 QRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
           Q A   T P   + + G    AG+    GP        P   P  AGE+  R A   P
Sbjct: 443 QGA---TGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEP 497



 Score = 28.9 bits (63), Expect = 8.7
 Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 11/94 (11%)

Query: 97   VGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG 156
            VG     GA G   P  PP   G+    G    PG     P    P G  P  PG G   
Sbjct: 1169 VGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGN----PG---PPGP-PGPPGPGIDM 1220

Query: 157  PSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKH 190
             +  G G R K   G +     R  Q A G  +H
Sbjct: 1221 SAFAGLGPREK---GPDPLQYMRADQAAGGLRQH 1251


>gi|111118974 collagen, type II, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 1418

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 70/253 (27%), Positives = 89/253 (35%), Gaps = 38/253 (15%)

Query: 98  GRRRGSGARGFSAP------CCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH 149
           G R   G RG + P        PP A GQ  A+G++ + G  G    P    P G     
Sbjct: 747 GARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQGEAGQKGDAGAPGPQGPSGAPGPQ 806

Query: 150 PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE----GETGASY 205
              G  GP         KG RG++    +     AAGR   P  G +G     G  G S 
Sbjct: 807 GPTGVTGP---------KGARGAQGPPGATGFPGAAGRVGPP--GSNGNPGPPGPPGPSG 855

Query: 206 PEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGE 265
            +   G   +S       +   Q         G+ G      GP+G   EGP G   L  
Sbjct: 856 KDGPKGARGDSGPPGRAGEPGLQGPAGPPGEKGEPG----DDGPSG--AEGPPGPQGLAG 909

Query: 266 QRAGATTTPGSRRRRRGAGRSAGWPHPGGPS-RPTRRNAPPARPDAAGEQCPRPAGARPR 324
           QR G    PG R  R       G+P   GPS  P ++ AP A  D        P G    
Sbjct: 910 QR-GIVGLPGQRGER-------GFPGLPGPSGEPGKQGAPGASGDRGPPGPVGPPGLTGP 961

Query: 325 QAEIETDPETGSD 337
             E   +   G+D
Sbjct: 962 AGEPGREGSPGAD 974



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 69/246 (28%), Positives = 82/246 (33%), Gaps = 34/246 (13%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGV-----CP 147
            G    SG RG   P  PP   G     G+E  PG     GR     +   +G       P
Sbjct: 939  GAPGASGDRGPPGPVGPPGLTGPAGEPGREGSPGADGPPGRDGAAGVKGDRGETGAVGAP 998

Query: 148  HHPG-KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYP 206
              PG  GS GP+     Q  +G  G++       G   A   + P+     +GE G    
Sbjct: 999  GAPGPPGSPGPAGPTGKQGDRGEAGAQ-GPMGPSGPAGARGIQGPQGPRGDKGEAGEPGE 1057

Query: 207  EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGG--GAALG 264
              L GH   + L         Q         GD+GA     GPAG    GP G  G    
Sbjct: 1058 RGLKGHRGFTGL---------QGLPGPPGPSGDQGA----SGPAGP--SGPRGPPGPVGP 1102

Query: 265  EQRAGATTTPG-----SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPA 319
              + GA   PG       R R G    AG P   GP  P     P     A     PR  
Sbjct: 1103 SGKDGANGIPGPIGPPGPRGRSGETGPAGPPGNPGPPGPPGPPGPGIDMSAFAGLGPREK 1162

Query: 320  GARPRQ 325
            G  P Q
Sbjct: 1163 GPDPLQ 1168



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 64/232 (27%), Positives = 76/232 (32%), Gaps = 22/232 (9%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKE--PKPGGRVTLPALHLPKGVCPHH-----P 150
           G R   G  G +    PP   G    RG++  P P G   LP    P G          P
Sbjct: 558 GLRGLPGKDGETGAAGPPGPAGPAGERGEQGAPGPSGFQGLPGPPGPPGEGGKPGDQGVP 617

Query: 151 GKGSAGPSRRGRGQRA-KGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
           G+  A      RG+R   G RGS      +  RG         P+      G  GA  P 
Sbjct: 618 GEAGAPGLVGPRGERGFPGERGSPGAQGLQGPRGLPGTPGTDGPKGASGPAGPPGAQGPP 677

Query: 208 ELHGHEAESLLLEALDDLAHQAALHAVRLD-GDEGALQVGHGPAGRELEGP----GGGAA 262
            L G   E          A  A     R D G++G         GR L GP    G   A
Sbjct: 678 GLQGMPGER-------GAAGIAGPKGDRGDVGEKGPEGAPGKDGGRGLTGPIGPPGPAGA 730

Query: 263 LGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
            GE+       P      RGA    G   P GP+          +P A GEQ
Sbjct: 731 NGEKGEVGPPGPAGSAGARGAPGERGETGPPGPAGFAGPPGADGQPGAKGEQ 782



 Score = 37.7 bits (86), Expect = 0.019
 Identities = 60/231 (25%), Positives = 74/231 (32%), Gaps = 32/231 (13%)

Query: 96   RVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSA 155
            RVG    +G  G   P  P    G   ARG    P GR   P L  P G        G  
Sbjct: 835  RVGPPGSNGNPGPPGPPGPSGKDGPKGARGDSGPP-GRAGEPGLQGPAGPPGEKGEPGDD 893

Query: 156  GPSRRGRGQRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHE 213
            GPS        +G  G    +    +RG+        P      +G  GAS      G  
Sbjct: 894  GPSGAEGPPGPQGLAGQRGIVGLPGQRGERGFPGLPGPSGEPGKQGAPGASGDRGPPGPV 953

Query: 214  AESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQ-RAGATT 272
                L     +            +G  GA     GP GR+    G     G++   GA  
Sbjct: 954  GPPGLTGPAGEPGR---------EGSPGA----DGPPGRD----GAAGVKGDRGETGAVG 996

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR-PAGAR 322
             PG          + G P   GP+ PT +        A G   P  PAGAR
Sbjct: 997  APG----------APGPPGSPGPAGPTGKQGDRGEAGAQGPMGPSGPAGAR 1037



 Score = 36.2 bits (82), Expect = 0.054
 Identities = 62/256 (24%), Positives = 80/256 (31%), Gaps = 39/256 (15%)

Query: 104 GARGFSAPCCPPAAGGQVAAR---GKEPKPGGRVTLPALHLPKG-VCPHHPGKGSAGPSR 159
           G  G   P  PP  GG  AA+   G + K GG   L  +  P G + P  P   +  P  
Sbjct: 93  GPPGPPGPPGPPGLGGNFAAQMAGGFDEKAGG-AQLGVMQGPMGPMGPRGPPGPAGAPGP 151

Query: 160 RG----------------RGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGA 203
           +G                 G R       +   +   G+     E+ P       G  G 
Sbjct: 152 QGFQGNPGEPGEPGVSGPMGPRGPPGPPGKPGDDGEAGKPGKAGERGPPGPQGARGFPGT 211

Query: 204 SYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAAL 263
                + GH         LD    +A    V+  G+ G+      P      GP G   L
Sbjct: 212 PGLPGVKGHRG----YPGLDGAKGEAGAPGVK--GESGS------PGENGSPGPMGPRGL 259

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPR----PA 319
             +R    T P      RG     G   P GP  P      P  P A GE  P     P 
Sbjct: 260 PGERG--RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPE 317

Query: 320 GARPRQAEIETDPETG 335
           GA+  + E  T    G
Sbjct: 318 GAQGPRGEPGTPGSPG 333



 Score = 35.0 bits (79), Expect = 0.12
 Identities = 65/249 (26%), Positives = 79/249 (31%), Gaps = 31/249 (12%)

Query: 96  RVGRRRGSGARGFSA---PCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH- 149
           R G    +GARG      P  PP   G     G    PG  G         P+G      
Sbjct: 265 RTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGPEGAQGPRG 324

Query: 150 -PGK-GSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
            PG  GS GP+         G  G++  S    G   A     PR     +G TG   P+
Sbjct: 325 EPGTPGSPGPAGASGNPGTDGIPGAK-GSAGAPGIAGAPGFPGPRGPPGPQGATGPLGPK 383

Query: 208 ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-----PGGGAA 262
              G             +A        + +      Q   GPAG E +      PGG   
Sbjct: 384 GQTGEPG----------IAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEPGGVGP 433

Query: 263 LGEQRAGATTTPGSRR--RRRGAGRSAGWPHPGGPSR---PTRRNAPPARPDAAGEQCPR 317
           +G    G    PG+R    + G     G P   GPS    P   N  P RP   G    R
Sbjct: 434 IGPP--GERGAPGNRGFPGQDGLAGPKGAPGERGPSGLAGPKGANGDPGRPGEPGLPGAR 491

Query: 318 PAGARPRQA 326
               RP  A
Sbjct: 492 GLTGRPGDA 500



 Score = 34.3 bits (77), Expect = 0.21
 Identities = 65/234 (27%), Positives = 80/234 (34%), Gaps = 20/234 (8%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGK----GSAG- 156
           G  G   P  PP   G    +G +  PG  G   +     P+G  P  PGK    G AG 
Sbjct: 132 GPMGPMGPRGPPGPAGAPGPQGFQGNPGEPGEPGVSGPMGPRGP-PGPPGKPGDDGEAGK 190

Query: 157 PSRRG-RG----QRAKGFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGASYPEEL 209
           P + G RG    Q A+GF G+      +  RG       K        +GE+G+      
Sbjct: 191 PGKAGERGPPGPQGARGFPGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGS 250

Query: 210 HGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGH--GPAGRELEGPGGGAALGEQR 267
            G      L           A  A   DG  G        GPAG     PG   A GE  
Sbjct: 251 PGPMGPRGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGP-GFPGAPGAKGEAG 309

Query: 268 AGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
                 P   +  RG   + G P P G S     +  P    +AG   P  AGA
Sbjct: 310 PTGARGPEGAQGPRGEPGTPGSPGPAGASGNPGTDGIPGAKGSAG--APGIAGA 361



 Score = 32.3 bits (72), Expect = 0.78
 Identities = 63/238 (26%), Positives = 73/238 (30%), Gaps = 31/238 (13%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGVCPHHPGKGSAGPS 158
           GARGF      P   G    +G    PG     G    P +    G    +   G  GP 
Sbjct: 204 GARGF------PGTPGLPGVKGHRGYPGLDGAKGEAGAPGVKGESGSPGENGSPGPMGP- 256

Query: 159 RRGRGQRAKGFRGSEMNSESRRGQTA----------AGREKHPRA-GCSGE-GETGASYP 206
           R   G+R +        +    GQ            AG    P A G  GE G TGA  P
Sbjct: 257 RGLPGERGRTGPAGAAGARGNDGQPGPAGPPGPVGPAGGPGFPGAPGAKGEAGPTGARGP 316

Query: 207 EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAALGE 265
           E   G   E              A      DG  GA      P      G PG     G 
Sbjct: 317 EGAQGPRGEP---GTPGSPGPAGASGNPGTDGIPGAKGSAGAPGIAGAPGFPGPRGPPGP 373

Query: 266 QRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
           Q A   T P   + + G    AG+    GP        P   P  AGE+  R A   P
Sbjct: 374 QGA---TGPLGPKGQTGEPGIAGFKGEQGPKGEPGPAGPQGAPGPAGEEGKRGARGEP 428



 Score = 28.9 bits (63), Expect = 8.7
 Identities = 29/94 (30%), Positives = 33/94 (35%), Gaps = 11/94 (11%)

Query: 97   VGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG 156
            VG     GA G   P  PP   G+    G    PG     P    P G  P  PG G   
Sbjct: 1100 VGPSGKDGANGIPGPIGPPGPRGRSGETGPAGPPGN----PG---PPGP-PGPPGPGIDM 1151

Query: 157  PSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKH 190
             +  G G R K   G +     R  Q A G  +H
Sbjct: 1152 SAFAGLGPREK---GPDPLQYMRADQAAGGLRQH 1182


>gi|197333868 T-box 2 [Homo sapiens]
          Length = 712

 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 68/281 (24%), Positives = 95/281 (33%), Gaps = 41/281 (14%)

Query: 60  KIHSLPYAKGGAPHWNSEFQTKAK-EIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAG 118
           KI + P+AKG     N   + + +  +PSL       +  R    GA   ++ C PP A 
Sbjct: 275 KIDNNPFAKGFRDTGNGRREKRKQLTLPSLRLYEEHCKPER---DGAESDASSCDPPPAR 331

Query: 119 GQVAARGKEPKP--------------------GGRVTLPALHLPKGVCPHHPGKGSAGPS 158
               + G  P P                      R++      P G     P   SA P+
Sbjct: 332 EPPTSPGAAPSPLRLHRARAEEKSCAADSDPEPERLSEERAGAPLG---RSPAPDSASPT 388

Query: 159 RRGRGQRAKGFRGSEMNSE-------------SRRGQTAAGREKHPRAGCSGEGETGASY 205
           R    +RA+  R  E   E             S   + A  R K      + EG+     
Sbjct: 389 RLTEPERARERRSPERGKEPAESGGDGPFGLRSLEKERAEARRKDEGRKEAAEGKEQGLA 448

Query: 206 PEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGE 265
           P  +    A  L    L  LA  + LH  +  G  GA Q      G+   GPG  +A+G 
Sbjct: 449 PLVVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFTMGPGAFSAMGM 508

Query: 266 QRAGATTTPGSRRRRRGAGRSAGWPHPG-GPSRPTRRNAPP 305
               A+   G      G G +AG    G GP+      A P
Sbjct: 509 GHLLASVAGGGNGGGGGPGTAAGLDAGGLGPAASAASTAAP 549


>gi|239758013 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 819

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 62/254 (24%), Positives = 97/254 (38%), Gaps = 55/254 (21%)

Query: 92  PRWTRVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG 151
           PRW R  +   +G++   A     AA   V ++G E KP       A             
Sbjct: 138 PRW-RAQKSAAAGSKNRGAGAQKAAAAAGVKSQGGE-KPQKAAAAGA------------- 182

Query: 152 KGSAGPSRRGRGQRAKGF---RGSEMNSESRRGQTAAGREK-----HPRAGCSGEGETGA 203
           K  +G   R RG +++G    +G +  ++SR G+T  GR K      P AG +     G 
Sbjct: 183 KSRSGKKPRRRGAKSRGDEDKKGRQREAKSRFGKTRGGRRKKHRRPKPAAGGAKSRRGGG 242

Query: 204 SYPEE--LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
             P++    G +A +                     G +  +    G   ++L   G  A
Sbjct: 243 KKPQKQRRRGQKAAT---------------------GGKSRVGKSRGGGDKKLRRQGQNA 281

Query: 262 AL-GEQRAGATTT---PGSRRRRRGAGRSAGWPHP---GGPSRPTRRNAPPARPDAAGEQ 314
           AL G +R GA T    P ++ R     +S G  +P    G  +P RR     +  AAG +
Sbjct: 282 ALAGAKRRGAATAGEKPAAKGRGGRGPKSLGGQNPRWGRGGKKPRRRGQKATKAAAAGTK 341

Query: 315 CPRPAGARPRQAEI 328
             R  G + + A +
Sbjct: 342 --RGGGGQQKAAVV 353



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/270 (24%), Positives = 90/270 (33%), Gaps = 37/270 (13%)

Query: 95  TRVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGS 154
           +R G+ RG   +    P   PAAGG  + RG     GG+   P     +G      GK  
Sbjct: 212 SRFGKTRGGRRKKHRRP--KPAAGGAKSRRG-----GGKK--PQKQRRRGQKAATGGKSR 262

Query: 155 AGPSRRGRGQRAKGF-RGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHE 213
            G SR G  ++ +   + + +    RRG   AG EK    G  G G           G  
Sbjct: 263 VGKSRGGGDKKLRRQGQNAALAGAKRRGAATAG-EKPAAKGRGGRGPKSLGGQNPRWGRG 321

Query: 214 AESLLLEALDDLAHQAALHAVRLDGDEGALQVG------HGPAGRELEGPGGGAALGEQR 267
            +             AA       G + A  VG          G++       AA  + R
Sbjct: 322 GKKPRRRGQKATKAAAAGTKRGGGGQQKAAVVGVKSRKKQRRRGKKPRRQKASAAGAKSR 381

Query: 268 AGATTTPGSRRRRRGAGRS---------------AGWPHPGGPSRPTRRNAPPA-----R 307
            G         +RRG GR                A  P  GG  +P RR    A     +
Sbjct: 382 GGGDKKGLREAKRRGDGRKKPRWQNPRRRAQKAPAAKPRGGGSKKPRRRGPKAAKSRGGK 441

Query: 308 PDAAGEQCPRPAGARPRQAEIETDPETGSD 337
             + G + PR  G + RQ   E   E+  D
Sbjct: 442 SRSGGGKKPRRRGQKARQKAAEAGAESRGD 471



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 82/354 (23%), Positives = 114/354 (32%), Gaps = 85/354 (24%)

Query: 16  KKGESGQSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWKIHSLPYAKGGAPHWN 75
           K+G  GQ     VG  S+K  RR  +K            P       +   ++GG    +
Sbjct: 341 KRGGGGQQKAAVVGVKSRKKQRRRGKK------------PRRQKASAAGAKSRGGG---D 385

Query: 76  SEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKP----G 131
            +   +AK        PRW    RR         AP   P  GG    R + PK     G
Sbjct: 386 KKGLREAKRRGDGRKKPRWQNPRRRAQK------APAAKPRGGGSKKPRRRGPKAAKSRG 439

Query: 132 GRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHP 191
           G+                  +   G   R RGQ+A+  + +E  +ESR G    GR+K  
Sbjct: 440 GK-----------------SRSGGGKKPRRRGQKARQ-KAAEAGAESR-GDKKQGRQKAS 480

Query: 192 RAGCSGEGETGASY----------PEELHGHEAESLLLEALDDLAHQAALHAV-----RL 236
            AG    G    S+            E  G +A +   ++      +    AV     R+
Sbjct: 481 AAGTKSRGGGLKSHSGKNLWRRGQKAEAAGEKATAAGAKSRGRKQPRRQKPAVAGAKSRV 540

Query: 237 DGDE--------GALQVGHGPAGRELEGPGGG---------AALGEQRAGATTTPGSR-- 277
            G +         A    HG  G +    GGG         AA  + R G    PG +  
Sbjct: 541 GGSKSRQRQKAVAAGATSHGGGGNKQSRGGGGNKPRQWGQTAAAAKTRGGGDKQPGWQKA 600

Query: 278 -----RRRRGAGRSAGWPHPGGPSRPTRRNAPPAR--PDAAGEQCPRPAGARPR 324
                + R G G    W      +    R  P  R   DAA  +     GA  R
Sbjct: 601 AAGVTKSRSGDGGKKAWRQKAAGTGAKSRKKPWRRGQKDAAAAEKAWATGATSR 654



 Score = 35.4 bits (80), Expect = 0.093
 Identities = 83/346 (23%), Positives = 126/346 (36%), Gaps = 53/346 (15%)

Query: 16  KKGESGQSGIGSVGRASQKTARRGKRKTNMLGV-----GIQICAPNLMWKIHSLPYAKG- 69
           ++G+  +      G  S+   ++G++K +  G      G++  +   +W+      A G 
Sbjct: 452 RRGQKARQKAAEAGAESRGDKKQGRQKASAAGTKSRGGGLKSHSGKNLWRRGQKAEAAGE 511

Query: 70  -----GAPHWNSEFQTKAKEIPSLHSVPRWTRVGRRRG-SGARGFSAPCCPPAAGGQVAA 123
                GA     +   + K  P++      +RVG  +     +  +A       GG   +
Sbjct: 512 KATAAGAKSRGRKQPRRQK--PAVAGAK--SRVGGSKSRQRQKAVAAGATSHGGGGNKQS 567

Query: 124 RG---KEPKPGGRVTLPALHLPKGVCPHHPG--KGSAG--PSRRGRG------QRAKGFR 170
           RG    +P+  G+    A    +G     PG  K +AG   SR G G      Q+A G  
Sbjct: 568 RGGGGNKPRQWGQTAAAAK--TRGGGDKQPGWQKAAAGVTKSRSGDGGKKAWRQKAAGTG 625

Query: 171 GSEMNSESRRGQT-AAGREKHPRAGCSGEGETG--------ASYPEELHGHEAESLLLEA 221
                   RRGQ  AA  EK    G +  G  G        A+   E     A     EA
Sbjct: 626 AKSRKKPWRRGQKDAAAAEKAWATGATSRGSGGKQPRWQKPAAAGSESSAAAAVGQEAEA 685

Query: 222 LDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRR 281
                 + A    R DG + A  VG  P  R  + P     LG+ R G     G++ R  
Sbjct: 686 RKKPRRRRAKS--RGDGGQNAA-VGINPWQRRGKKP----RLGKSRGGG----GAKSRGS 734

Query: 282 GAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAE 327
           G  +S G    G  SR  ++ A        G +  R  GA+ R  E
Sbjct: 735 GGAKSRG--SGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGE 778



 Score = 28.9 bits (63), Expect = 8.7
 Identities = 47/203 (23%), Positives = 69/203 (33%), Gaps = 30/203 (14%)

Query: 22  QSGIGSVGRASQKTARRGKRKTNMLGVGIQICAPNLMWKIHSLPYAKGGA-PHWN----- 75
           Q   G+  ++ +K  RRG++            A    W   +     GG  P W      
Sbjct: 619 QKAAGTGAKSRKKPWRRGQKDA---------AAAEKAWATGATSRGSGGKQPRWQKPAAA 669

Query: 76  ---SEFQTKAKEIPSLHSVPRWTRVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGG 132
              S       +       PR  R  + RG G +  +    P    G+    GK    GG
Sbjct: 670 GSESSAAAAVGQEAEARKKPRRRRA-KSRGDGGQNAAVGINPWQRRGKKPRLGKSRGGGG 728

Query: 133 ---RVTLPALHLPKGVCPHHPGKGSA-------GPSRRGRGQRAKGFRGSEMNSESRRGQ 182
              R +  A     G      GK +A       G ++R RG  AK   G +  +   +  
Sbjct: 729 AKSRGSGGAKSRGSGGAKSRSGKKAAASKSHGGGGAKRRRGGGAKSRSGEKAVTAGGQKA 788

Query: 183 TAAGREKHPRA-GCSGEGETGAS 204
            AAG +K PR     G G+  A+
Sbjct: 789 AAAGGKKPPRVKSRGGRGQKAAA 811


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 69/243 (28%), Positives = 80/243 (32%), Gaps = 61/243 (25%)

Query: 98   GRRRGSGARGFSAPCCP---PAAGGQVAARGKE-----PKPGGRVTLPALHLPKGVCPHH 149
            G    +GA GF+ P  P   P   G+    G++     P P G    P  H P GV    
Sbjct: 837  GENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPGLK 896

Query: 150  PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPR-AGCSGE----GETGAS 204
             G+G+ GP        A GF GS            AGR   P  AG  G     GE G  
Sbjct: 897  GGRGTQGPPG------ATGFPGS------------AGRVGPPGPAGAPGPAGPLGEPGKE 938

Query: 205  YPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE---------LE 255
             P  L G           D  +H          GD G      GP  +           +
Sbjct: 939  GPPGLRG-----------DPGSHGRV-------GDRGPAGPPGGPGDKGDPGEDGQPGPD 980

Query: 256  GPGGGAALGEQRAGATTTPGSRRRRR--GAGRSAGWPHPGGPSRPTRRNAPPARPDAAGE 313
            GP G A    QR G    PG R  R   G    AG P   GP+  T    PP      G 
Sbjct: 981  GPPGPAGTTGQR-GIVGMPGQRGERGMPGLPGPAGTPGKVGPTGATGDKGPPGPVGPPGS 1039

Query: 314  QCP 316
              P
Sbjct: 1040 NGP 1042



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 60/224 (26%), Positives = 72/224 (32%), Gaps = 26/224 (11%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
           G     GARG   P  PP   G    +G EP P G V       P G   +   +G  GP
Sbjct: 789 GTAGNDGARGLPGPLGPPGPAGPTGEKG-EPGPRGLVG------PPGSRGNPGSRGENGP 841

Query: 158 SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
           +       A GF G +   + + G      E   +      G  G +     HG      
Sbjct: 842 T------GAVGFAGPQ-GPDGQPGVKGEPGEPGQKGDAGSPGPQGLAGSPGPHGPNGVPG 894

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVG-HGPAGRELEGPGGGAALGEQRAGATTTPGS 276
           L         Q    A    G  G  +VG  GPAG     PG    LGE   G    PG 
Sbjct: 895 L---KGGRGTQGPPGATGFPGSAG--RVGPPGPAG----APGPAGPLGE--PGKEGPPGL 943

Query: 277 RRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAG 320
           R      GR       G P  P  +  P        +  P PAG
Sbjct: 944 RGDPGSHGRVGDRGPAGPPGGPGDKGDPGEDGQPGPDGPPGPAG 987



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 63/251 (25%), Positives = 79/251 (31%), Gaps = 38/251 (15%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKE--PKPGGRVTLPALHLPKGV--------CP 147
           G+R   G  G   P  P    G    RG++  P P G   LP    P G          P
Sbjct: 639 GQRGAPGKDGEVGPSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVP 698

Query: 148 HHPGK-GSAGPSRRGRGQRAK-GFRGSE--MNSESRRGQTAAGREKHPRAGCSGEGETGA 203
             PG  G  GP    RG+R   G RG          +G         P+      G  G 
Sbjct: 699 GDPGAVGPLGP----RGERGNPGERGEPGITGLPGEKGMAGGHGPDGPKGSPGPSGTPGD 754

Query: 204 SYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG----PGG 259
           + P  L G   E  +         +  +      G++GA         R L G    PG 
Sbjct: 755 TGPPGLQGMPGERGIAGTPGPKGDRGGI------GEKGAEGTAGNDGARGLPGPLGPPGP 808

Query: 260 GAALGEQ----RAGATTTPGSR-----RRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDA 310
               GE+      G    PGSR     R   G   + G+  P GP         P  P  
Sbjct: 809 AGPTGEKGEPGPRGLVGPPGSRGNPGSRGENGPTGAVGFAGPQGPDGQPGVKGEPGEPGQ 868

Query: 311 AGEQ-CPRPAG 320
            G+   P P G
Sbjct: 869 KGDAGSPGPQG 879



 Score = 35.4 bits (80), Expect = 0.093
 Identities = 75/301 (24%), Positives = 96/301 (31%), Gaps = 52/301 (17%)

Query: 96   RVGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSA 155
            +VG    +G +G   P  PP + G V   G E  P G    P      G       +G  
Sbjct: 1018 KVGPTGATGDKGPPGPVGPPGSNGPVGEPGPE-GPAGNDGTPG---RDGAVGERGDRGDP 1073

Query: 156  GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAE 215
            GP+     Q A G  G  + +    GQ      + P       G+ G   P+   G + +
Sbjct: 1074 GPAGLPGSQGAPGTPG-PVGAPGDAGQRGDPGSRGPIGPPGRAGKRGLPGPQGPRGDKGD 1132

Query: 216  SLLLEALDDLAHQAALHAVRLDGDEGALQVGH-GPAGRELEG-PGGGAALGEQRAGATTT 273
                            H  R  GD G  Q GH G  G  L+G PG     GEQ +     
Sbjct: 1133 ----------------HGDR--GDRG--QKGHRGFTG--LQGLPGPPGPNGEQGSAGIPG 1170

Query: 274  P-GSRRRRRGAGRSAGWPHPG-----------------GPSRPTRRNAPPARPDAAGEQC 315
            P G R      G S    +PG                 GP  P     PP  P   G   
Sbjct: 1171 PFGPRGPPGPVGPSGKEGNPGPLGPIGPPGVRGSVGEAGPEGPPGEPGPPGPPGPPGHLT 1230

Query: 316  PRPAGARPRQAEIETD--PETGSDSFSTWTSYEFN---YARPKSHSSPLSTSRDPKSSYT 370
                       E   D  PE   D  +     + +   +A  KS SS + T R P  S  
Sbjct: 1231 AALGDIMGHYDESMPDPLPEFTEDQAAPDDKNKTDPGVHATLKSLSSQIETMRSPDGSKK 1290

Query: 371  H 371
            H
Sbjct: 1291 H 1291



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 70/252 (27%), Positives = 89/252 (35%), Gaps = 42/252 (16%)

Query: 97  VGRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPG-KG 153
           +G R   G RG   P     A GQ  A G   KPG  G + +P         P +PG KG
Sbjct: 335 LGPRGMPGERGRLGP---QGAPGQRGAHGMPGKPGPMGPLGIPG----SSGFPGNPGMKG 387

Query: 154 SAGPSRRGRGQRAKGFRGSEMNSESRRGQTA----AGREKHPRAGCSGEGETGASYPEEL 209
            AGP+         G RG E   + +RG+T      G    P A    +G  GA  P   
Sbjct: 388 EAGPT---------GARGPE-GPQGQRGETGPPGPVGSPGLPGA-IGTDGTPGAKGPTGS 436

Query: 210 HGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVG--HGPAGRELE-GPGGGAALGEQ 266
            G                Q +     + G  G   V    G AG + E GP G       
Sbjct: 437 PGTSGPPGSAGPPGSPGPQGSTGPQGIRGQPGDPGVPGFKGEAGPKGEPGPHG------- 489

Query: 267 RAGATTTPGSRRRR--RGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPR 324
             G    PG   +R  RG   + G P P G      R AP  R     +  P P GA+  
Sbjct: 490 IQGPIGPPGEEGKRGPRGDPGTVGPPGPVG-----ERGAPGNRGFPGSDGLPGPKGAQGE 544

Query: 325 QAEIETDPETGS 336
           +  + +    GS
Sbjct: 545 RGPVGSSGPKGS 556



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 70/287 (24%), Positives = 89/287 (31%), Gaps = 57/287 (19%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTL-----------PALHLPKGVCPHHPG 151
           +G RG   P  PP + G    RG + +PG R              P    P G  P HPG
Sbjct: 125 TGIRGRPGPAGPPGSQGPRGERGPKGRPGPRGPQGIDGEPGVPGQPGAPGPPGH-PSHPG 183

Query: 152 K-GSAGP-SRRGRGQRAKGFRGSEMN-------------------SESRRGQTAAGREKH 190
             G + P S +  G   K   GS++                     +   G T    E  
Sbjct: 184 PDGLSRPFSAQMAGLDEKSGLGSQVGLMPGSVGPVGPRGPQGLQGQQGGAGPTGPPGEPG 243

Query: 191 PRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPA 250
                   G  G   P    G + E        ++    +  A    G  G   +     
Sbjct: 244 DPGPMGPIGSRGPEGPPGKPGEDGEPGRNGNPGEVGFAGSPGARGFPGAPGLPGLKGHRG 303

Query: 251 GRELEGPGG--GAALGEQRAGATTT------------PGSRRR--------RRGAGRSAG 288
            + LEGP G  GA   +  AG T              PG R R        +RGA    G
Sbjct: 304 HKGLEGPKGEVGAPGSKGEAGPTGPMGAMGPLGPRGMPGERGRLGPQGAPGQRGAHGMPG 363

Query: 289 WPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETG 335
            P P GP      +  P  P   GE    P GAR  +       ETG
Sbjct: 364 KPGPMGPLGIPGSSGFPGNPGMKGE--AGPTGARGPEGPQGQRGETG 408


>gi|40805823 collagen, type XXII, alpha 1 [Homo sapiens]
          Length = 1626

 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 66/258 (25%), Positives = 77/258 (29%), Gaps = 52/258 (20%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG-----GRVTLPALHLPKGV------- 145
           GR    G RG       P   G+V  RG +  PG     GRV  P L   +G        
Sbjct: 542 GRDGSKGMRGEPGELGEPGLPGEVGMRGPQGPPGLPGPPGRVGAPGLQGERGEKGTRGEK 601

Query: 146 -------CPHHPG----KGSAGPSRRGRGQRAKG---------FRGSEMNSESRRGQTAA 185
                   P  PG    +G  GPS     Q  KG           GS +  E  +G+  A
Sbjct: 602 GERGLDGFPGKPGDTGQQGRPGPSGVAGPQGEKGDVGPAGPPGVPGSVVQQEGLKGEQGA 661

Query: 186 GREKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQV 245
              +  +      G  G   PE   G      L     D+        + L G  G   V
Sbjct: 662 PGPRGHQGAPGPPGARGPIGPEGRDGPPGLQGLRGKKGDMGPPGIPGLLGLQGPPGPPGV 721

Query: 246 GHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPP 305
              P      GPGG   L     G    PG            G P P GP      N PP
Sbjct: 722 PGPP------GPGGSPGL----PGEIGFPGK----------PGPPGPTGPPGKDGPNGPP 761

Query: 306 ARPDAAGEQCPRPAGARP 323
             P   GE   R     P
Sbjct: 762 GPPGTKGEPGERGEDGLP 779



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 60/226 (26%), Positives = 72/226 (31%), Gaps = 41/226 (18%)

Query: 104  GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGK-GSAGPSRRGR 162
            G  G   P  PP A GQ  A G     G               P  PG  G+ GPS    
Sbjct: 889  GELGPQGPTGPPGAKGQEGAHGAPGAAGN--------------PGAPGHVGAPGPSGPPG 934

Query: 163  GQRAKGFRGSEMNSESRRGQTAAGREKHP----------------RAGCSGEGETGASYP 206
               A G RG+      R  + AAG E  P                  G   +GE G    
Sbjct: 935  SVGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGPRGDPGAPGLPGPPGKGKDGEPGLRGS 994

Query: 207  EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQ 266
              L G          +   +   AL    + GD GA  +   P  R    PG G A    
Sbjct: 995  PGLPGPLGTKAACGKVRG-SENCALGGQCVKGDRGAPGIPGSPGSR--GDPGIGVA---G 1048

Query: 267  RAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
              G +  PG     +G+  S G P   GP  P  R+  P  P   G
Sbjct: 1049 PPGPSGPPGD----KGSPGSRGLPGFPGPQGPAGRDGAPGNPGERG 1090



 Score = 31.6 bits (70), Expect = 1.3
 Identities = 57/218 (26%), Positives = 73/218 (33%), Gaps = 28/218 (12%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG-PSRRG- 161
           G  G + P  PP   G+   RG++  P G+  L      +G+      KG AG P   G 
Sbjct: 753 GKDGPNGPPGPPGTKGEPGERGEDGLP-GKPGLRGEIGEQGLAGRPGEKGEAGLPGAPGF 811

Query: 162 ---RGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSG--------------EGETGAS 204
              RG++       E+     +G      E  P AG  G               GE G  
Sbjct: 812 PGVRGEKGDQGEKGELGLPGLKGDRGEKGEAGP-AGPPGLPGTTSLFTPHPRMPGEQGPK 870

Query: 205 YPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGAL----QVGHGPAGRELEGPGGG 260
             +   G   E  L     +L  Q         G EGA       G+  A   +  PG  
Sbjct: 871 GEKGDPGLPGEPGLQGRPGELGPQGPTGPPGAKGQEGAHGAPGAAGNPGAPGHVGAPGPS 930

Query: 261 AALGEQRA-GATTTPG--SRRRRRGAGRSAGWPHPGGP 295
              G   A G   TPG    R  +GA    G P P GP
Sbjct: 931 GPPGSVGAPGLRGTPGKDGERGEKGAAGEEGSPGPVGP 968



 Score = 30.4 bits (67), Expect = 3.0
 Identities = 67/251 (26%), Positives = 83/251 (33%), Gaps = 44/251 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG-KGSAG 156
            G     G  GF  P  PP   G+    GKE  P G+   P     +G     PG KG  G
Sbjct: 1351 GENGSPGLPGFLGPRGPPGEPGEKGVPGKEGVP-GKPGEPGFKGERG----DPGIKGDKG 1405

Query: 157  PSRRGRGQRA-------KGFRGSEMNSESRRGQTAAGREKHPRA-----GCSGEG---ET 201
            P   G+GQ         KG  G  M  +   G+        P       G  GE    ET
Sbjct: 1406 PP-GGKGQPGDPGIPGHKGHTGL-MGPQGLPGENGPVGPPGPPGQPGFPGLRGESPSMET 1463

Query: 202  GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG-----ALQVGHGPAGRE--- 253
                 +E  G + E+ L   L  +       +    G  G      L    GP G     
Sbjct: 1464 LRRLIQEELGKQLETRLAYLLAQMPPAYMKSSQGRPGPPGPPGKDGLPGRAGPMGEPGRP 1523

Query: 254  ----LEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTR----RNAPP 305
                LEGP G      +R GA   PG+     G G       PG P +P      ++  P
Sbjct: 1524 GQGGLEGPSGPIGPKGER-GAKGDPGA----PGVGLRGEMGPPGIPGQPGEPGYAKDGLP 1578

Query: 306  ARPDAAGEQCP 316
              P   GE  P
Sbjct: 1579 GIPGPQGETGP 1589


>gi|18643383 inositol 1,4,5-trisphosphate 3-kinase C [Homo sapiens]
          Length = 683

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 36/105 (34%), Positives = 44/105 (41%), Gaps = 11/105 (10%)

Query: 267 RAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQA 326
           R G    PG +R   GAG  AG P  GGP   T  ++  + P+ AG   P P G    QA
Sbjct: 30  RGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAG-LGPAP-GTESPQA 87

Query: 327 EIETDPETGSDSFSTWTSYEFNYARPKSHSSPLSTSRDPKSSYTH 371
           E  TD +T   +       E    RPK  + P     D  S  TH
Sbjct: 88  EFWTDGQTEPAAAGLGVETE----RPKQKTEP-----DRSSLRTH 123


>gi|158854042 hypothetical protein LOC222183 [Homo sapiens]
          Length = 653

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 72/321 (22%), Positives = 111/321 (34%), Gaps = 57/321 (17%)

Query: 96  RVGRRRGSGAR--------GFSAPCCPPAAGGQVAARGKEP----KPGGRVTLPALHL-- 141
           + G +R SG+R        G+ +P     +G +  A G  P     P  + + P+  +  
Sbjct: 288 KTGSQRSSGSRSPSPSGGSGWGSPQRNGGSGQRSGAHGGRPGSAHSPPDKPSSPSPRVRD 347

Query: 142 -PKGVCPHHPGKGSAGPSRR------GRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAG 194
                 P  P +G   PS R      GRG RA G  G       RR        +  R+ 
Sbjct: 348 KAAAAAPTPPARGKESPSPRSAPSSQGRGGRAAGGAGRRRRRRRRR--------RRSRSS 399

Query: 195 CSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGREL 254
            S     G   P       +   L  A               D   G    G GP     
Sbjct: 400 ASAPRRRGRRRPRPAPPRGSSRSLSRARSS-----------SDSGSGRGAPGPGPEPGSE 448

Query: 255 EGPGGGAALGEQR------AGATTTPGSRRRRRG-----AGRSAGWPHPGGPSRPTRRNA 303
            G GG     ++R      A  + +PG+  RR G     + RS G PHP   S  + R+ 
Sbjct: 449 RGHGGHGKRAKERPPRARPASTSPSPGAHGRRGGPEGKSSSRSPG-PHP--RSWSSSRSP 505

Query: 304 PPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARPKSHS-SPLSTS 362
             +R  +A ++   P+ +   +  +  D +   +  +  +  E   AR +S S SP+   
Sbjct: 506 SKSRSRSAEKRPHSPSRSPSPKKPLSRDKD--GEGRARHSEAEATRARRRSRSYSPIRKR 563

Query: 363 RDPKSSYTHTHTHTHTEPAPV 383
           R    S+      T     P+
Sbjct: 564 RRDSPSFMEPRRITSARKRPI 584


>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
          Length = 1519

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 68/250 (27%), Positives = 93/250 (37%), Gaps = 34/250 (13%)

Query: 103 SGARGFSAPCCP--------PAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGS 154
           SG  G  +P  P        P  G      G E   G  V L  + LP    P    +GS
Sbjct: 207 SGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPE---GEYVELLEVTLPVRGSPTD-AEGS 262

Query: 155 AGPSRRGRGQRAKGFRGSEMNSESRRG--QTAAGREKHPRAGCSGEGETGASYPEELHGH 212
            G SR       KG  G   +   R    Q   G      A   GEG +  + PE   G 
Sbjct: 263 PGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQDGARPPGEGSSTGASPESPPGA 322

Query: 213 EA--ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGA 270
           EA  E+ +LE  +  A      +       G L+ G G  G+  EGP G           
Sbjct: 323 EAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELR-GGGGGGQGAEGPPG--------TPR 373

Query: 271 TTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQC----PRPAGARPRQA 326
            T  G+RR++R AGR A     GG S P    +P  + DA+ ++     P P+  +  + 
Sbjct: 374 RTGKGNRRKKRAAGRGA--LSRGGDSAPL---SPGDKEDASHQEALGNLPSPSEHKLPEC 428

Query: 327 EIETDPETGS 336
            +  +   GS
Sbjct: 429 HLVKEEYEGS 438


>gi|169168886 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 278

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 55/213 (25%), Positives = 71/213 (33%), Gaps = 15/213 (7%)

Query: 150 PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAG--CSGEGETGASYPE 207
           P K    PS  G  +  +G   +E+    R   T   R    R G   +G G   A    
Sbjct: 33  PPKMQGAPSLAGEEEGKRGVGDAEV----RHWGTLTSRASGMRVGIWAAGGGLAAAGERN 88

Query: 208 ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQR 267
            +      S  +   ++ A   A+ A  L G    L VG G    +L G    AA   Q 
Sbjct: 89  SVRAVSFSSGRVGVREEAAGHLAVGAAGLTGAHADLAVGRGAELAQLLGADAAAAAAVQH 148

Query: 268 AGATTTPGSRRRRRGAGRSAG-------WPHPGGPSRPTRRNAPPARPDAAGEQCPRPAG 320
                    RR  R   R A            GG  R    +A P RP     Q P  AG
Sbjct: 149 EAHARRAARRRLVRAPARPAAVLADGRLQGGQGGQRRSVGAHALPGRPRVPPWQPPAAAG 208

Query: 321 ARPR--QAEIETDPETGSDSFSTWTSYEFNYAR 351
           A      AE E D E  +D   T   + ++  R
Sbjct: 209 APGAYPAAEGEEDHEGDADGAHTGGGHGWHCGR 241


>gi|111118972 collagen, type XI, alpha 2 isoform 2 preproprotein [Homo
            sapiens]
          Length = 1650

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/220 (24%), Positives = 73/220 (33%), Gaps = 14/220 (6%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
            GR    G  G   P  PP   G+   +G+   PG + T       KG    H   G  GP
Sbjct: 974  GRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGT-------KGNKGEHGPPGPPGP 1026

Query: 158  SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                    A G  G E  +   +G   A  ++  R      G  G        G + E+ 
Sbjct: 1027 IGPVGQPGAAGADG-EPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETG 1085

Query: 218  LLEALDDLAHQAALHAVRLDGDEGAL----QVGH-GPAGRELEGPGGGAALGEQRAGATT 272
             +  +              +G +G       VG+ GP G + E PG   + G Q      
Sbjct: 1086 DVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGE-PGESGSPGIQGEPGVK 1144

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
             P   R  +G     G P P GP  PT  + P   P   G
Sbjct: 1145 GPRGERGEKGESGQPGEPGPPGPKGPTGDDGPKGNPGPVG 1184



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 66/236 (27%), Positives = 76/236 (32%), Gaps = 46/236 (19%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGKEPKPG-----------GRVTLPALHLPKGVCPHHPG 151
           SG RG   P  P    G   A GK    G           G   LP    P G     PG
Sbjct: 748 SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGF----PG 803

Query: 152 -KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE----GETGASYP 206
            KG  GP  +       G RG E+  + + G         P+ G +GE    GE G   P
Sbjct: 804 PKGPPGPPGKDGLPGHPGQRG-EVGFQGKTGPPGPPGVVGPQ-GAAGETGPMGERGHPGP 861

Query: 207 EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-------RELEGPGG 259
               G +           L   A     + D          GPAG       R L G  G
Sbjct: 862 PGPPGEQG----------LPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAG 911

Query: 260 GAAL-GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
           G  L G +       P      RGA  S      GGP  P  R  P   P AAGE+
Sbjct: 912 GPGLKGNEGPSGPPGPAGSPGERGAAGS------GGPIGPPGRPGPQGPPGAAGEK 961



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 39/230 (16%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG----KGSAGPSR 159
           G +G + P   P   G +  +GK   PG               P +PG    KGS G   
Sbjct: 686 GPKGRTGPTGDPGPPGLMGEKGKLGVPG--------------LPGYPGRQGPKGSLGFPG 731

Query: 160 RGRGQRAKGFRGSEMNSESR--RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                  KG RG    S  R  RG T    ++ PR      G  G S  +  HG   E  
Sbjct: 732 FPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG 791

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEG-PGGGAALGEQ-RAGATTTP 274
           L                   G +G      GP G++ L G PG    +G Q + G    P
Sbjct: 792 L---------PGPQGPNGFPGPKGP----PGPPGKDGLPGHPGQRGEVGFQGKTGPPGPP 838

Query: 275 GSRRRRRGAGRSAGWP---HPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
           G    +  AG +       HPG P  P  +  P        +  P P GA
Sbjct: 839 GVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGA 888



 Score = 36.2 bits (82), Expect = 0.054
 Identities = 70/276 (25%), Positives = 92/276 (33%), Gaps = 66/276 (23%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGK-----------EPKPGGRVTLPALHLPKGV- 145
            G+R   G +G + P  PP   G   A G+            P P G   LP     +G  
Sbjct: 821  GQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTK 880

Query: 146  ----CPHHPGK-GSAG----PSRRGRGQRA--KGFRGSE--------MNSESRRGQTAAG 186
                 P  PGK G AG    P  RG    A   G +G+E          S   RG   +G
Sbjct: 881  GDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSG 940

Query: 187  REKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVG 246
                P      +G  GA+  + + G +                    +   G +G     
Sbjct: 941  GPIGPPGRPGPQGPPGAAGEKGVPGEKG------------------PIGPTGRDGV---- 978

Query: 247  HGPAGRELEGPGG--GAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             GP G  L GP G  G A  +   G    PG +  +   G   G P P GP        P
Sbjct: 979  QGPVG--LPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEH-GPPGPPGPI------GP 1029

Query: 305  PARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFS 340
              +P AAG       GAR  Q       + G+  F+
Sbjct: 1030 VGQPGAAG--ADGEPGARGPQGHFGAKGDEGTRGFN 1063



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 66/255 (25%), Positives = 83/255 (32%), Gaps = 40/255 (15%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGK--------------EPKPGGRVTLP---ALHLPKGV 145
           SG RG   P  PP   G    RG               EP P G+   P    L  P+G 
Sbjct: 520 SGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGA 579

Query: 146 CPHHPGKGSAG----PSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGET 201
              H  KG  G    P   G      G  G E    ++  Q  +G  + P       G  
Sbjct: 580 IGPHGEKGPQGKPGLPGMPG-SDGPPGHPGKEGPPGTKGNQGPSG-PQGPLGYPGPRGVK 637

Query: 202 GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
           G      L GH+ E        +         + + GD G + V   P  R  +GP G  
Sbjct: 638 GVDGIRGLKGHKGEK------GEDGFPGFKGDIGVKGDRGEVGV---PGSRGEDGPEG-- 686

Query: 262 ALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSR--PTRRNAPPARPDAAGEQCPRPA 319
              + R G T  PG        G+      PG P R  P      P  P A+GE+  R  
Sbjct: 687 --PKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGL 744

Query: 320 GAR--PRQAEIETDP 332
             +  PR     T P
Sbjct: 745 SGKSGPRGERGPTGP 759



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 52/200 (26%), Positives = 69/200 (34%), Gaps = 34/200 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPG-KGS 154
            GR+ G GA+G       P   G V   G   KPG  G   LP     +G     PG  G 
Sbjct: 1244 GRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQG----RPGATGQ 1299

Query: 155  AGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEA 214
            AGP          G RG +  ++  +G         P      +G+ G   P+   G + 
Sbjct: 1300 AGPPGPVGPPGLPGLRG-DAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKG 1358

Query: 215  ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTP 274
            E                  + + G  G +  G GP G  L GP      G + A   T P
Sbjct: 1359 E------------------MGIPGASGPIGPG-GPPG--LPGPA-----GPKGAKGATGP 1392

Query: 275  GSRRRRRGAGRSAGWPHPGG 294
            G  +  +G     G P P G
Sbjct: 1393 GGPKGEKGVQGPPGHPGPPG 1412



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 57/241 (23%), Positives = 73/241 (30%), Gaps = 28/241 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH--PG-K 152
            G   G G +G   P  PP   G    RG     G  G    P    P G       PG K
Sbjct: 908  GTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEK 967

Query: 153  GSAGPSRRGRGQRAKGFRGSE-----MNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
            G  GP+ R   Q   G  G          +  +G+     +K  +     +GE G   P 
Sbjct: 968  GPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGN---KGEHGPPGPP 1024

Query: 208  ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAALGEQ 266
               G   +     A  +   +         GDEG       P    L+G PG     GE 
Sbjct: 1025 GPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGET 1084

Query: 267  R-AGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQ 325
               G    PG              P P GP+ P   + P   P   G   P      P +
Sbjct: 1085 GDVGPMGPPGP-------------PGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGE 1131

Query: 326  A 326
            +
Sbjct: 1132 S 1132



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 59/249 (23%), Positives = 83/249 (33%), Gaps = 43/249 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAA------RGKEPKPG--GRVTLPALHLPKGVCPHH 149
            G +   G  GF     PP  GG          RG++ +PG  G       + P G     
Sbjct: 1175 GPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKR 1234

Query: 150  PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTA-AGREKHP----------------R 192
               GS G   R  G+ AKG  G+ + +  + G    AG    P                R
Sbjct: 1235 GPAGSPGSEGRQGGKGAKGDPGA-IGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGR 1293

Query: 193  AGCSGE-GETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG-----ALQVG 246
             G +G+ G  G   P  L G   ++    A  +  H   +  +   G++G      L   
Sbjct: 1294 PGATGQAGPPGPVGPPGLPGLRGDA---GAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGP 1350

Query: 247  HGPAGR--ELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             G  G+  E+  PG    +G         P   +  +GA        PGGP        P
Sbjct: 1351 QGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGA------TGPGGPKGEKGVQGP 1404

Query: 305  PARPDAAGE 313
            P  P   GE
Sbjct: 1405 PGHPGPPGE 1413



 Score = 33.1 bits (74), Expect = 0.46
 Identities = 64/257 (24%), Positives = 83/257 (32%), Gaps = 34/257 (13%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG- 156
           G+    G +G   P  P    G    RG +   G R          G+  H   KG  G 
Sbjct: 608 GKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIR----------GLKGHKGEKGEDGF 657

Query: 157 PSRRG----RGQRAK----GFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEE 208
           P  +G    +G R +    G RG +   E  +G+T    +  P      +G+ G      
Sbjct: 658 PGFKGDIGVKGDRGEVGVPGSRGED-GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPG 716

Query: 209 LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGGGA----AL 263
             G +     L             A  L G  G  +   GP G R   GP G      A 
Sbjct: 717 YPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGP-RGERGPTGPRGQRGPRGATGKSGAK 775

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGE-------QCP 316
           G         P   R   G     G+P P GP  P  ++  P  P   GE         P
Sbjct: 776 GTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPP 835

Query: 317 RPAG-ARPRQAEIETDP 332
            P G   P+ A  ET P
Sbjct: 836 GPPGVVGPQGAAGETGP 852



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 55/228 (24%), Positives = 74/228 (32%), Gaps = 26/228 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSA 155
            G +   G RGF+ P  P    G     G++ + G  G +  P    P+G    +   G  
Sbjct: 1052 GAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQ 1111

Query: 156  GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAE 215
            GP          G +G    S S   Q   G  K PR     +GE+G        G +  
Sbjct: 1112 GPPGGVGNLGPPGEKGEPGESGSPGIQGEPG-VKGPRGERGEKGESGQPGEPGPPGPKGP 1170

Query: 216  SLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPG 275
            +       D   +     V   GD G    G GP G++      GA       G    PG
Sbjct: 1171 T------GDDGPKGNPGPVGFPGDPGPPGEG-GPRGQD------GAKGDRGEDGEPGQPG 1217

Query: 276  SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
            S           G     GP  P  +  P   P + G Q  + A   P
Sbjct: 1218 S----------PGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDP 1255


>gi|111118968 collagen, type XI, alpha 2 isoform 3 preproprotein [Homo
            sapiens]
          Length = 1629

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/220 (24%), Positives = 73/220 (33%), Gaps = 14/220 (6%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
            GR    G  G   P  PP   G+   +G+   PG + T       KG    H   G  GP
Sbjct: 953  GRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGT-------KGNKGEHGPPGPPGP 1005

Query: 158  SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                    A G  G E  +   +G   A  ++  R      G  G        G + E+ 
Sbjct: 1006 IGPVGQPGAAGADG-EPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETG 1064

Query: 218  LLEALDDLAHQAALHAVRLDGDEGAL----QVGH-GPAGRELEGPGGGAALGEQRAGATT 272
             +  +              +G +G       VG+ GP G + E PG   + G Q      
Sbjct: 1065 DVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGE-PGESGSPGIQGEPGVK 1123

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
             P   R  +G     G P P GP  PT  + P   P   G
Sbjct: 1124 GPRGERGEKGESGQPGEPGPPGPKGPTGDDGPKGNPGPVG 1163



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 66/236 (27%), Positives = 76/236 (32%), Gaps = 46/236 (19%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGKEPKPG-----------GRVTLPALHLPKGVCPHHPG 151
           SG RG   P  P    G   A GK    G           G   LP    P G     PG
Sbjct: 727 SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGF----PG 782

Query: 152 -KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE----GETGASYP 206
            KG  GP  +       G RG E+  + + G         P+ G +GE    GE G   P
Sbjct: 783 PKGPPGPPGKDGLPGHPGQRG-EVGFQGKTGPPGPPGVVGPQ-GAAGETGPMGERGHPGP 840

Query: 207 EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-------RELEGPGG 259
               G +           L   A     + D          GPAG       R L G  G
Sbjct: 841 PGPPGEQG----------LPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAG 890

Query: 260 GAAL-GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
           G  L G +       P      RGA  S      GGP  P  R  P   P AAGE+
Sbjct: 891 GPGLKGNEGPSGPPGPAGSPGERGAAGS------GGPIGPPGRPGPQGPPGAAGEK 940



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 39/230 (16%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG----KGSAGPSR 159
           G +G + P   P   G +  +GK   PG               P +PG    KGS G   
Sbjct: 665 GPKGRTGPTGDPGPPGLMGEKGKLGVPG--------------LPGYPGRQGPKGSLGFPG 710

Query: 160 RGRGQRAKGFRGSEMNSESR--RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                  KG RG    S  R  RG T    ++ PR      G  G S  +  HG   E  
Sbjct: 711 FPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG 770

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEG-PGGGAALGEQ-RAGATTTP 274
           L                   G +G      GP G++ L G PG    +G Q + G    P
Sbjct: 771 L---------PGPQGPNGFPGPKGP----PGPPGKDGLPGHPGQRGEVGFQGKTGPPGPP 817

Query: 275 GSRRRRRGAGRSAGWP---HPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
           G    +  AG +       HPG P  P  +  P        +  P P GA
Sbjct: 818 GVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGA 867



 Score = 36.2 bits (82), Expect = 0.054
 Identities = 70/276 (25%), Positives = 92/276 (33%), Gaps = 66/276 (23%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGK-----------EPKPGGRVTLPALHLPKGV- 145
            G+R   G +G + P  PP   G   A G+            P P G   LP     +G  
Sbjct: 800  GQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTK 859

Query: 146  ----CPHHPGK-GSAG----PSRRGRGQRA--KGFRGSE--------MNSESRRGQTAAG 186
                 P  PGK G AG    P  RG    A   G +G+E          S   RG   +G
Sbjct: 860  GDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSG 919

Query: 187  REKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVG 246
                P      +G  GA+  + + G +                    +   G +G     
Sbjct: 920  GPIGPPGRPGPQGPPGAAGEKGVPGEKG------------------PIGPTGRDGV---- 957

Query: 247  HGPAGRELEGPGG--GAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             GP G  L GP G  G A  +   G    PG +  +   G   G P P GP        P
Sbjct: 958  QGPVG--LPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEH-GPPGPPGPI------GP 1008

Query: 305  PARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFS 340
              +P AAG       GAR  Q       + G+  F+
Sbjct: 1009 VGQPGAAG--ADGEPGARGPQGHFGAKGDEGTRGFN 1042



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 66/255 (25%), Positives = 83/255 (32%), Gaps = 40/255 (15%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGK--------------EPKPGGRVTLP---ALHLPKGV 145
           SG RG   P  PP   G    RG               EP P G+   P    L  P+G 
Sbjct: 499 SGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGA 558

Query: 146 CPHHPGKGSAG----PSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGET 201
              H  KG  G    P   G      G  G E    ++  Q  +G  + P       G  
Sbjct: 559 IGPHGEKGPQGKPGLPGMPG-SDGPPGHPGKEGPPGTKGNQGPSG-PQGPLGYPGPRGVK 616

Query: 202 GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
           G      L GH+ E        +         + + GD G + V   P  R  +GP G  
Sbjct: 617 GVDGIRGLKGHKGEK------GEDGFPGFKGDIGVKGDRGEVGV---PGSRGEDGPEG-- 665

Query: 262 ALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSR--PTRRNAPPARPDAAGEQCPRPA 319
              + R G T  PG        G+      PG P R  P      P  P A+GE+  R  
Sbjct: 666 --PKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGL 723

Query: 320 GAR--PRQAEIETDP 332
             +  PR     T P
Sbjct: 724 SGKSGPRGERGPTGP 738



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 52/200 (26%), Positives = 69/200 (34%), Gaps = 34/200 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPG-KGS 154
            GR+ G GA+G       P   G V   G   KPG  G   LP     +G     PG  G 
Sbjct: 1223 GRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQG----RPGATGQ 1278

Query: 155  AGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEA 214
            AGP          G RG +  ++  +G         P      +G+ G   P+   G + 
Sbjct: 1279 AGPPGPVGPPGLPGLRG-DAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKG 1337

Query: 215  ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTP 274
            E                  + + G  G +  G GP G  L GP      G + A   T P
Sbjct: 1338 E------------------MGIPGASGPIGPG-GPPG--LPGPA-----GPKGAKGATGP 1371

Query: 275  GSRRRRRGAGRSAGWPHPGG 294
            G  +  +G     G P P G
Sbjct: 1372 GGPKGEKGVQGPPGHPGPPG 1391



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 57/241 (23%), Positives = 73/241 (30%), Gaps = 28/241 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH--PG-K 152
            G   G G +G   P  PP   G    RG     G  G    P    P G       PG K
Sbjct: 887  GTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEK 946

Query: 153  GSAGPSRRGRGQRAKGFRGSE-----MNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
            G  GP+ R   Q   G  G          +  +G+     +K  +     +GE G   P 
Sbjct: 947  GPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGN---KGEHGPPGPP 1003

Query: 208  ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAALGEQ 266
               G   +     A  +   +         GDEG       P    L+G PG     GE 
Sbjct: 1004 GPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGET 1063

Query: 267  R-AGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQ 325
               G    PG              P P GP+ P   + P   P   G   P      P +
Sbjct: 1064 GDVGPMGPPGP-------------PGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGE 1110

Query: 326  A 326
            +
Sbjct: 1111 S 1111



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 59/249 (23%), Positives = 83/249 (33%), Gaps = 43/249 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAA------RGKEPKPG--GRVTLPALHLPKGVCPHH 149
            G +   G  GF     PP  GG          RG++ +PG  G       + P G     
Sbjct: 1154 GPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKR 1213

Query: 150  PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTA-AGREKHP----------------R 192
               GS G   R  G+ AKG  G+ + +  + G    AG    P                R
Sbjct: 1214 GPAGSPGSEGRQGGKGAKGDPGA-IGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGR 1272

Query: 193  AGCSGE-GETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG-----ALQVG 246
             G +G+ G  G   P  L G   ++    A  +  H   +  +   G++G      L   
Sbjct: 1273 PGATGQAGPPGPVGPPGLPGLRGDA---GAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGP 1329

Query: 247  HGPAGR--ELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             G  G+  E+  PG    +G         P   +  +GA        PGGP        P
Sbjct: 1330 QGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGA------TGPGGPKGEKGVQGP 1383

Query: 305  PARPDAAGE 313
            P  P   GE
Sbjct: 1384 PGHPGPPGE 1392



 Score = 33.1 bits (74), Expect = 0.46
 Identities = 64/257 (24%), Positives = 83/257 (32%), Gaps = 34/257 (13%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG- 156
           G+    G +G   P  P    G    RG +   G R          G+  H   KG  G 
Sbjct: 587 GKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIR----------GLKGHKGEKGEDGF 636

Query: 157 PSRRG----RGQRAK----GFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEE 208
           P  +G    +G R +    G RG +   E  +G+T    +  P      +G+ G      
Sbjct: 637 PGFKGDIGVKGDRGEVGVPGSRGED-GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPG 695

Query: 209 LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGGGA----AL 263
             G +     L             A  L G  G  +   GP G R   GP G      A 
Sbjct: 696 YPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGP-RGERGPTGPRGQRGPRGATGKSGAK 754

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGE-------QCP 316
           G         P   R   G     G+P P GP  P  ++  P  P   GE         P
Sbjct: 755 GTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPP 814

Query: 317 RPAG-ARPRQAEIETDP 332
            P G   P+ A  ET P
Sbjct: 815 GPPGVVGPQGAAGETGP 831



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 55/228 (24%), Positives = 74/228 (32%), Gaps = 26/228 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSA 155
            G +   G RGF+ P  P    G     G++ + G  G +  P    P+G    +   G  
Sbjct: 1031 GAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQ 1090

Query: 156  GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAE 215
            GP          G +G    S S   Q   G  K PR     +GE+G        G +  
Sbjct: 1091 GPPGGVGNLGPPGEKGEPGESGSPGIQGEPG-VKGPRGERGEKGESGQPGEPGPPGPKGP 1149

Query: 216  SLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPG 275
            +       D   +     V   GD G    G GP G++      GA       G    PG
Sbjct: 1150 T------GDDGPKGNPGPVGFPGDPGPPGEG-GPRGQD------GAKGDRGEDGEPGQPG 1196

Query: 276  SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
            S           G     GP  P  +  P   P + G Q  + A   P
Sbjct: 1197 S----------PGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDP 1234


>gi|111118970 collagen, type XI, alpha 2 isoform 1 preproprotein [Homo
            sapiens]
          Length = 1736

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 54/220 (24%), Positives = 73/220 (33%), Gaps = 14/220 (6%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGP 157
            GR    G  G   P  PP   G+   +G+   PG + T       KG    H   G  GP
Sbjct: 1060 GRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGT-------KGNKGEHGPPGPPGP 1112

Query: 158  SRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                    A G  G E  +   +G   A  ++  R      G  G        G + E+ 
Sbjct: 1113 IGPVGQPGAAGADG-EPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETG 1171

Query: 218  LLEALDDLAHQAALHAVRLDGDEGAL----QVGH-GPAGRELEGPGGGAALGEQRAGATT 272
             +  +              +G +G       VG+ GP G + E PG   + G Q      
Sbjct: 1172 DVGPMGPPGPPGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGE-PGESGSPGIQGEPGVK 1230

Query: 273  TPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAG 312
             P   R  +G     G P P GP  PT  + P   P   G
Sbjct: 1231 GPRGERGEKGESGQPGEPGPPGPKGPTGDDGPKGNPGPVG 1270



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 66/236 (27%), Positives = 76/236 (32%), Gaps = 46/236 (19%)

Query: 103  SGARGFSAPCCPPAAGGQVAARGKEPKPG-----------GRVTLPALHLPKGVCPHHPG 151
            SG RG   P  P    G   A GK    G           G   LP    P G     PG
Sbjct: 834  SGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERGLPGPQGPNGF----PG 889

Query: 152  -KGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGE----GETGASYP 206
             KG  GP  +       G RG E+  + + G         P+ G +GE    GE G   P
Sbjct: 890  PKGPPGPPGKDGLPGHPGQRG-EVGFQGKTGPPGPPGVVGPQ-GAAGETGPMGERGHPGP 947

Query: 207  EELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-------RELEGPGG 259
                G +           L   A     + D          GPAG       R L G  G
Sbjct: 948  PGPPGEQG----------LPGTAGKEGTKGDPGPPGAPGKDGPAGLRGFPGERGLPGTAG 997

Query: 260  GAAL-GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQ 314
            G  L G +       P      RGA  S      GGP  P  R  P   P AAGE+
Sbjct: 998  GPGLKGNEGPSGPPGPAGSPGERGAAGS------GGPIGPPGRPGPQGPPGAAGEK 1047



 Score = 38.1 bits (87), Expect = 0.014
 Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 39/230 (16%)

Query: 104 GARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPG----KGSAGPSR 159
           G +G + P   P   G +  +GK   PG               P +PG    KGS G   
Sbjct: 772 GPKGRTGPTGDPGPPGLMGEKGKLGVPG--------------LPGYPGRQGPKGSLGFPG 817

Query: 160 RGRGQRAKGFRGSEMNSESR--RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESL 217
                  KG RG    S  R  RG T    ++ PR      G  G S  +  HG   E  
Sbjct: 818 FPGASGEKGARGLSGKSGPRGERGPTGPRGQRGPRGATGKSGAKGTSGGDGPHGPPGERG 877

Query: 218 LLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRE-LEG-PGGGAALGEQ-RAGATTTP 274
           L                   G +G      GP G++ L G PG    +G Q + G    P
Sbjct: 878 L---------PGPQGPNGFPGPKGP----PGPPGKDGLPGHPGQRGEVGFQGKTGPPGPP 924

Query: 275 GSRRRRRGAGRSAGWP---HPGGPSRPTRRNAPPARPDAAGEQCPRPAGA 321
           G    +  AG +       HPG P  P  +  P        +  P P GA
Sbjct: 925 GVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTKGDPGPPGA 974



 Score = 36.2 bits (82), Expect = 0.054
 Identities = 70/276 (25%), Positives = 92/276 (33%), Gaps = 66/276 (23%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGK-----------EPKPGGRVTLPALHLPKGV- 145
            G+R   G +G + P  PP   G   A G+            P P G   LP     +G  
Sbjct: 907  GQRGEVGFQGKTGPPGPPGVVGPQGAAGETGPMGERGHPGPPGPPGEQGLPGTAGKEGTK 966

Query: 146  ----CPHHPGK-GSAG----PSRRGRGQRA--KGFRGSE--------MNSESRRGQTAAG 186
                 P  PGK G AG    P  RG    A   G +G+E          S   RG   +G
Sbjct: 967  GDPGPPGAPGKDGPAGLRGFPGERGLPGTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSG 1026

Query: 187  REKHPRAGCSGEGETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVG 246
                P      +G  GA+  + + G +                    +   G +G     
Sbjct: 1027 GPIGPPGRPGPQGPPGAAGEKGVPGEKG------------------PIGPTGRDGV---- 1064

Query: 247  HGPAGRELEGPGG--GAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             GP G  L GP G  G A  +   G    PG +  +   G   G P P GP        P
Sbjct: 1065 QGPVG--LPGPAGPPGVAGEDGDKGEVGDPGQKGTKGNKGEH-GPPGPPGPI------GP 1115

Query: 305  PARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFS 340
              +P AAG       GAR  Q       + G+  F+
Sbjct: 1116 VGQPGAAG--ADGEPGARGPQGHFGAKGDEGTRGFN 1149



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 66/255 (25%), Positives = 83/255 (32%), Gaps = 40/255 (15%)

Query: 103 SGARGFSAPCCPPAAGGQVAARGK--------------EPKPGGRVTLP---ALHLPKGV 145
           SG RG   P  PP   G    RG               EP P G+   P    L  P+G 
Sbjct: 606 SGPRGLLGPKGPPGIPGPPGVRGMDGPQGPKGSLGPQGEPGPPGQQGTPGTQGLPGPQGA 665

Query: 146 CPHHPGKGSAG----PSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGET 201
              H  KG  G    P   G      G  G E    ++  Q  +G  + P       G  
Sbjct: 666 IGPHGEKGPQGKPGLPGMPG-SDGPPGHPGKEGPPGTKGNQGPSG-PQGPLGYPGPRGVK 723

Query: 202 GASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGA 261
           G      L GH+ E        +         + + GD G + V   P  R  +GP G  
Sbjct: 724 GVDGIRGLKGHKGEK------GEDGFPGFKGDIGVKGDRGEVGV---PGSRGEDGPEG-- 772

Query: 262 ALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSR--PTRRNAPPARPDAAGEQCPRPA 319
              + R G T  PG        G+      PG P R  P      P  P A+GE+  R  
Sbjct: 773 --PKGRTGPTGDPGPPGLMGEKGKLGVPGLPGYPGRQGPKGSLGFPGFPGASGEKGARGL 830

Query: 320 GAR--PRQAEIETDP 332
             +  PR     T P
Sbjct: 831 SGKSGPRGERGPTGP 845



 Score = 35.8 bits (81), Expect = 0.071
 Identities = 52/200 (26%), Positives = 69/200 (34%), Gaps = 34/200 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPG-KGS 154
            GR+ G GA+G       P   G V   G   KPG  G   LP     +G     PG  G 
Sbjct: 1330 GRQGGKGAKGDPGAIGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQG----RPGATGQ 1385

Query: 155  AGPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEA 214
            AGP          G RG +  ++  +G         P      +G+ G   P+   G + 
Sbjct: 1386 AGPPGPVGPPGLPGLRG-DAGAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSPGQKG 1444

Query: 215  ESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTP 274
            E                  + + G  G +  G GP G  L GP      G + A   T P
Sbjct: 1445 E------------------MGIPGASGPIGPG-GPPG--LPGPA-----GPKGAKGATGP 1478

Query: 275  GSRRRRRGAGRSAGWPHPGG 294
            G  +  +G     G P P G
Sbjct: 1479 GGPKGEKGVQGPPGHPGPPG 1498



 Score = 34.7 bits (78), Expect = 0.16
 Identities = 57/241 (23%), Positives = 73/241 (30%), Gaps = 28/241 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHH--PG-K 152
            G   G G +G   P  PP   G    RG     G  G    P    P G       PG K
Sbjct: 994  GTAGGPGLKGNEGPSGPPGPAGSPGERGAAGSGGPIGPPGRPGPQGPPGAAGEKGVPGEK 1053

Query: 153  GSAGPSRRGRGQRAKGFRGSE-----MNSESRRGQTAAGREKHPRAGCSGEGETGASYPE 207
            G  GP+ R   Q   G  G          +  +G+     +K  +     +GE G   P 
Sbjct: 1054 GPIGPTGRDGVQGPVGLPGPAGPPGVAGEDGDKGEVGDPGQKGTKGN---KGEHGPPGPP 1110

Query: 208  ELHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEG-PGGGAALGEQ 266
               G   +     A  +   +         GDEG       P    L+G PG     GE 
Sbjct: 1111 GPIGPVGQPGAAGADGEPGARGPQGHFGAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGET 1170

Query: 267  R-AGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQ 325
               G    PG              P P GP+ P   + P   P   G   P      P +
Sbjct: 1171 GDVGPMGPPGP-------------PGPRGPAGPNGADGPQGPPGGVGNLGPPGEKGEPGE 1217

Query: 326  A 326
            +
Sbjct: 1218 S 1218



 Score = 33.9 bits (76), Expect = 0.27
 Identities = 59/249 (23%), Positives = 83/249 (33%), Gaps = 43/249 (17%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAA------RGKEPKPG--GRVTLPALHLPKGVCPHH 149
            G +   G  GF     PP  GG          RG++ +PG  G       + P G     
Sbjct: 1261 GPKGNPGPVGFPGDPGPPGEGGPRGQDGAKGDRGEDGEPGQPGSPGPTGENGPPGPLGKR 1320

Query: 150  PGKGSAGPSRRGRGQRAKGFRGSEMNSESRRGQTA-AGREKHP----------------R 192
               GS G   R  G+ AKG  G+ + +  + G    AG    P                R
Sbjct: 1321 GPAGSPGSEGRQGGKGAKGDPGA-IGAPGKTGPVGPAGPAGKPGPDGLRGLPGSVGQQGR 1379

Query: 193  AGCSGE-GETGASYPEELHGHEAESLLLEALDDLAHQAALHAVRLDGDEG-----ALQVG 246
             G +G+ G  G   P  L G   ++    A  +  H   +  +   G++G      L   
Sbjct: 1380 PGATGQAGPPGPVGPPGLPGLRGDA---GAKGEKGHPGLIGLIGPPGEQGEKGDRGLPGP 1436

Query: 247  HGPAGR--ELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAP 304
             G  G+  E+  PG    +G         P   +  +GA        PGGP        P
Sbjct: 1437 QGSPGQKGEMGIPGASGPIGPGGPPGLPGPAGPKGAKGA------TGPGGPKGEKGVQGP 1490

Query: 305  PARPDAAGE 313
            P  P   GE
Sbjct: 1491 PGHPGPPGE 1499



 Score = 33.1 bits (74), Expect = 0.46
 Identities = 64/257 (24%), Positives = 83/257 (32%), Gaps = 34/257 (13%)

Query: 98  GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPGGRVTLPALHLPKGVCPHHPGKGSAG- 156
           G+    G +G   P  P    G    RG +   G R          G+  H   KG  G 
Sbjct: 694 GKEGPPGTKGNQGPSGPQGPLGYPGPRGVKGVDGIR----------GLKGHKGEKGEDGF 743

Query: 157 PSRRG----RGQRAK----GFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEE 208
           P  +G    +G R +    G RG +   E  +G+T    +  P      +G+ G      
Sbjct: 744 PGFKGDIGVKGDRGEVGVPGSRGED-GPEGPKGRTGPTGDPGPPGLMGEKGKLGVPGLPG 802

Query: 209 LHGHEAESLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAG-RELEGPGGGA----AL 263
             G +     L             A  L G  G  +   GP G R   GP G      A 
Sbjct: 803 YPGRQGPKGSLGFPGFPGASGEKGARGLSGKSGP-RGERGPTGPRGQRGPRGATGKSGAK 861

Query: 264 GEQRAGATTTPGSRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGE-------QCP 316
           G         P   R   G     G+P P GP  P  ++  P  P   GE         P
Sbjct: 862 GTSGGDGPHGPPGERGLPGPQGPNGFPGPKGPPGPPGKDGLPGHPGQRGEVGFQGKTGPP 921

Query: 317 RPAG-ARPRQAEIETDP 332
            P G   P+ A  ET P
Sbjct: 922 GPPGVVGPQGAAGETGP 938



 Score = 30.8 bits (68), Expect = 2.3
 Identities = 55/228 (24%), Positives = 74/228 (32%), Gaps = 26/228 (11%)

Query: 98   GRRRGSGARGFSAPCCPPAAGGQVAARGKEPKPG--GRVTLPALHLPKGVCPHHPGKGSA 155
            G +   G RGF+ P  P    G     G++ + G  G +  P    P+G    +   G  
Sbjct: 1138 GAKGDEGTRGFNGPPGPIGLQGLPGPSGEKGETGDVGPMGPPGPPGPRGPAGPNGADGPQ 1197

Query: 156  GPSRRGRGQRAKGFRGSEMNSESRRGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAE 215
            GP          G +G    S S   Q   G  K PR     +GE+G        G +  
Sbjct: 1198 GPPGGVGNLGPPGEKGEPGESGSPGIQGEPG-VKGPRGERGEKGESGQPGEPGPPGPKGP 1256

Query: 216  SLLLEALDDLAHQAALHAVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPG 275
            +       D   +     V   GD G    G GP G++      GA       G    PG
Sbjct: 1257 T------GDDGPKGNPGPVGFPGDPGPPGEG-GPRGQD------GAKGDRGEDGEPGQPG 1303

Query: 276  SRRRRRGAGRSAGWPHPGGPSRPTRRNAPPARPDAAGEQCPRPAGARP 323
            S           G     GP  P  +  P   P + G Q  + A   P
Sbjct: 1304 S----------PGPTGENGPPGPLGKRGPAGSPGSEGRQGGKGAKGDP 1341


>gi|23397672 homeobox D4 [Homo sapiens]
          Length = 255

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 43/138 (31%), Positives = 55/138 (39%), Gaps = 13/138 (9%)

Query: 238 GDEGALQVGHGPAGRELEGPG--GGAALGEQR-AGATTTPGSRRRRRGAGRSAGWP--HP 292
           G++GA   G G  G + + PG       GEQ   G+   PGS    RG G+  G P  H 
Sbjct: 30  GEQGADYYGGGAQGADFQPPGLYPRPDFGEQPFGGSGPGPGSALPARGHGQEPGGPGGHY 89

Query: 293 GGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARP 352
             P  P    APPA P A     P P GAR         P +G+        Y +     
Sbjct: 90  AAPGEPC--PAPPAPPPA-----PLP-GARAYSQSDPKQPPSGTALKQPAVVYPWMKKVH 141

Query: 353 KSHSSPLSTSRDPKSSYT 370
            +  +P  T  +PK S T
Sbjct: 142 VNSVNPNYTGGEPKRSRT 159


>gi|239751026 PREDICTED: hypothetical protein XP_002347678 [Homo
           sapiens]
          Length = 304

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 69/265 (26%), Positives = 88/265 (33%), Gaps = 38/265 (14%)

Query: 125 GKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFR-----GSEMNSESR 179
           G  P  G  +       P+G      G G+AGP   GRG    G R              
Sbjct: 62  GGGPAAGSAILRAGSRSPRGA-----GPGAAGPRAAGRGGAGGGGRCCTRGRGRFPCAGS 116

Query: 180 RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEAL-------DDLAHQAALH 232
            G+ A  R  H  + C         +P+ L G EAE     AL          A  AALH
Sbjct: 117 GGRGARSRGCHSPSCCRSSSCAWHRWPQ-LRGREAEPRASPALLICIAPRPRPALPAALH 175

Query: 233 AVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHP 292
                G      +    A  +L   G  A     RA   T P    R R  G  +G    
Sbjct: 176 I----GARATAGLAAKRAQPQLCSAGTAARGRRTRASPPTPP----RPRPPGLRSGDVPR 227

Query: 293 GGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARP 352
           GG     R   P  R  A G    +    RP +  +   P     SF T       +A  
Sbjct: 228 GG----ARVERPTGRRGAGGRGGAQRIPPRPLRRLVPIHPHPSHWSFCTRLLE--GWAPA 281

Query: 353 KSHSSPLSTSRDPKSSYTHTHTHTH 377
            +HS  L       +++T+TH HTH
Sbjct: 282 VTHSERLV------AAHTYTHIHTH 300


>gi|239745455 PREDICTED: hypothetical protein XP_002343496 [Homo
           sapiens]
          Length = 304

 Score = 40.4 bits (93), Expect = 0.003
 Identities = 69/265 (26%), Positives = 88/265 (33%), Gaps = 38/265 (14%)

Query: 125 GKEPKPGGRVTLPALHLPKGVCPHHPGKGSAGPSRRGRGQRAKGFR-----GSEMNSESR 179
           G  P  G  +       P+G      G G+AGP   GRG    G R              
Sbjct: 62  GGGPAAGSAILRAGSRSPRGA-----GPGAAGPRAAGRGGAGGGGRCCTRGRGRFPCAGS 116

Query: 180 RGQTAAGREKHPRAGCSGEGETGASYPEELHGHEAESLLLEAL-------DDLAHQAALH 232
            G+ A  R  H  + C         +P+ L G EAE     AL          A  AALH
Sbjct: 117 GGRGARSRGCHSPSCCRSSSCAWHRWPQ-LRGREAEPRASPALLICIAPRPRPALPAALH 175

Query: 233 AVRLDGDEGALQVGHGPAGRELEGPGGGAALGEQRAGATTTPGSRRRRRGAGRSAGWPHP 292
                G      +    A  +L   G  A     RA   T P    R R  G  +G    
Sbjct: 176 I----GARATAGLAAKRAQPQLCSAGTAARGRRTRASPPTPP----RPRPPGLRSGDVPR 227

Query: 293 GGPSRPTRRNAPPARPDAAGEQCPRPAGARPRQAEIETDPETGSDSFSTWTSYEFNYARP 352
           GG     R   P  R  A G    +    RP +  +   P     SF T       +A  
Sbjct: 228 GG----ARVERPTGRRGAGGRGGAQRIPPRPLRRLVPIHPHPSHWSFCTRLLE--GWAPA 281

Query: 353 KSHSSPLSTSRDPKSSYTHTHTHTH 377
            +HS  L       +++T+TH HTH
Sbjct: 282 VTHSERLV------AAHTYTHIHTH 300


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.132    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,125,278
Number of Sequences: 37866
Number of extensions: 1301715
Number of successful extensions: 8087
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 103
Number of HSP's successfully gapped in prelim test: 643
Number of HSP's that attempted gapping in prelim test: 6507
Number of HSP's gapped (non-prelim): 1967
length of query: 404
length of database: 18,247,518
effective HSP length: 105
effective length of query: 299
effective length of database: 14,271,588
effective search space: 4267204812
effective search space used: 4267204812
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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