Guide to the Human Genome
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Search of human proteins with 239740950

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|239740950 PREDICTED: similar to mitogen-activated protein
kinase 8 interacting protein 1 [Homo sapiens]
         (442 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|239740950 PREDICTED: similar to mitogen-activated protein kin...   909   0.0  
gi|169211037 PREDICTED: similar to mitogen-activated protein kin...   837   0.0  
gi|4885433 mitogen-activated protein kinase 8 interacting protei...   643   0.0  
gi|6912492 mitogen-activated protein kinase 8 interacting protei...   352   5e-97
gi|7706537 mitogen-activated protein kinase 8 interacting protei...   352   5e-97
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom...    61   2e-09
gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein i...    43   5e-04
gi|50511947 cajalin 2 isoform b [Homo sapiens]                         42   9e-04
gi|50511945 cajalin 2 isoform a [Homo sapiens]                         42   9e-04
gi|10047134 cajalin 2 isoform c [Homo sapiens]                         42   9e-04
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...    42   0.001
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    40   0.004
gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]         39   0.007
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]              39   0.009
gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]        38   0.021
gi|90403598 mesoderm posterior 2 homolog [Homo sapiens]                37   0.027
gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]    37   0.036
gi|54144629 numb homolog isoform 4 [Homo sapiens]                      37   0.047
gi|20070356 numb homolog isoform 3 [Homo sapiens]                      37   0.047
gi|50083291 amyloid beta A4 precursor protein-binding, family B,...    36   0.061
gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo ...    36   0.061
gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo s...    36   0.061
gi|18093112 ABT1-associated protein [Homo sapiens]                     36   0.061
gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo ...    35   0.10 
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ...    35   0.10 
gi|54144627 numb homolog isoform 2 [Homo sapiens]                      35   0.14 
gi|54144625 numb homolog isoform 1 [Homo sapiens]                      35   0.14 
gi|49640014 ubiquitin associated and SH3 domain containing, A sh...    35   0.14 
gi|9507221 ubiquitin associated and SH3 domain containing, A lon...    35   0.14 
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]        35   0.14 

>gi|239740950 PREDICTED: similar to mitogen-activated protein kinase
           8 interacting protein 1 [Homo sapiens]
          Length = 442

 Score =  909 bits (2348), Expect = 0.0
 Identities = 442/442 (100%), Positives = 442/442 (100%)

Query: 1   MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60
           MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP
Sbjct: 1   MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60

Query: 61  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHA 120
           GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHA
Sbjct: 61  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHA 120

Query: 121 QLELVSLRPCFGDYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTP 180
           QLELVSLRPCFGDYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTP
Sbjct: 121 QLELVSLRPCFGDYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTP 180

Query: 181 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 240
           DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL
Sbjct: 181 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 240

Query: 241 EVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 300
           EVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV
Sbjct: 241 EVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 300

Query: 301 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQE 360
           KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQE
Sbjct: 301 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQE 360

Query: 361 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 420
           AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR
Sbjct: 361 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 420

Query: 421 AFQQFHKQFVEYTCPTEDIYLE 442
           AFQQFHKQFVEYTCPTEDIYLE
Sbjct: 421 AFQQFHKQFVEYTCPTEDIYLE 442


>gi|169211037 PREDICTED: similar to mitogen-activated protein kinase
           8 interacting protein 1 [Homo sapiens]
          Length = 423

 Score =  837 bits (2162), Expect = 0.0
 Identities = 418/442 (94%), Positives = 420/442 (95%), Gaps = 19/442 (4%)

Query: 1   MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60
           MLQMDLIDATGDTPGAE   EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP
Sbjct: 1   MLQMDLIDATGDTPGAE---EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 57

Query: 61  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHA 120
           GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK         SRHLHQQPTLL     
Sbjct: 58  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKK---------SRHLHQQPTLL----- 103

Query: 121 QLELVSLRPCFGDYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTP 180
             ELVSLRPCF DYSDESDSAIVYDNC SVSSPYESAIGEEYEEASRPQPPACLSKDSTP
Sbjct: 104 --ELVSLRPCFRDYSDESDSAIVYDNCASVSSPYESAIGEEYEEASRPQPPACLSKDSTP 161

Query: 181 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 240
           DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL
Sbjct: 162 DEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPEL 221

Query: 241 EVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 300
           EVDDPLLVELQAEDYWYEAYNMRTGARG FTAYYAIEVTKEPEHMAALAKNSDWVDQFRV
Sbjct: 222 EVDDPLLVELQAEDYWYEAYNMRTGARGIFTAYYAIEVTKEPEHMAALAKNSDWVDQFRV 281

Query: 301 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQE 360
           KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIG+KADDSQE
Sbjct: 282 KFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGIKADDSQE 341

Query: 361 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 420
           AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR
Sbjct: 342 AKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGR 401

Query: 421 AFQQFHKQFVEYTCPTEDIYLE 442
           AFQQFHKQFVEYTCPTE+IYLE
Sbjct: 402 AFQQFHKQFVEYTCPTENIYLE 423


>gi|4885433 mitogen-activated protein kinase 8 interacting protein 1
           [Homo sapiens]
          Length = 711

 Score =  643 bits (1658), Expect = 0.0
 Identities = 333/422 (78%), Positives = 345/422 (81%), Gaps = 25/422 (5%)

Query: 24  DEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG---DTYRPKRPTTLNLFPQV 80
           D + AA    AG P     +E        S  +++ PG G       P  P      P+ 
Sbjct: 312 DPDPAAYPSTAGRPHPSISEEEEGFDCLSSPERAEPPGGGWRGSLGEPPPP------PRA 365

Query: 81  QLSQDTLNNNSLGKKYKQPRPHHRSRHLHQQPTLLVDEHAQLELVSLRPCFGDYSDESDS 140
            LS DT   +    KY                TL+VDEHAQLELVSLRPCFGDYSDESDS
Sbjct: 366 SLSSDTSALSYDSVKY----------------TLVVDEHAQLELVSLRPCFGDYSDESDS 409

Query: 141 AIVYDNCVSVSSPYESAIGEEYEEASRPQPPACLSKDSTPDEPDVHFSKKFLNIFMSGRS 200
           A VYDNC SVSSPYESAIGEEYEEA RPQPPACLS+DSTPDEPDVHFSKKFLN+FMSGRS
Sbjct: 410 ATVYDNCASVSSPYESAIGEEYEEAPRPQPPACLSEDSTPDEPDVHFSKKFLNVFMSGRS 469

Query: 201 RSSSAESFGLFSCIINREEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAY 260
           RSSSAESFGLFSCIIN EEQEQTHR IFRFVPRHEDE ELEVDDPLLVELQAEDYWYEAY
Sbjct: 470 RSSSAESFGLFSCIINGEEQEQTHRAIFRFVPRHEDELELEVDDPLLVELQAEDYWYEAY 529

Query: 261 NMRTGARGFFTAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAA 320
           NMRTGARG F AYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKG+ VL AA
Sbjct: 530 NMRTGARGVFPAYYAIEVTKEPEHMAALAKNSDWVDQFRVKFLGSVQVPYHKGNDVLCAA 589

Query: 321 MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFRGY 380
           MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISF GY
Sbjct: 590 MQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADDSQEAKGNKCSHFFQLKNISFCGY 649

Query: 381 HPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAESVGRAFQQFHKQFVEYTCPTEDIY 440
           HPKNNKYFGFITKH ADHRFACHVFVSEDSTKALAESVGRAFQQF+KQFVEYTCPTEDIY
Sbjct: 650 HPKNNKYFGFITKHPADHRFACHVFVSEDSTKALAESVGRAFQQFYKQFVEYTCPTEDIY 709

Query: 441 LE 442
           LE
Sbjct: 710 LE 711



 Score =  192 bits (489), Expect = 4e-49
 Identities = 93/96 (96%), Positives = 94/96 (97%)

Query: 1   MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 60
           MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP
Sbjct: 91  MLQMDLIDATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGP 150

Query: 61  GSGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKY 96
           GSGDTYRPKRPTTLNLFPQV  SQDTLNNNSLGKK+
Sbjct: 151 GSGDTYRPKRPTTLNLFPQVPRSQDTLNNNSLGKKH 186


>gi|6912492 mitogen-activated protein kinase 8 interacting protein 2
           isoform 1 [Homo sapiens]
          Length = 824

 Score =  352 bits (902), Expect = 5e-97
 Identities = 179/337 (53%), Positives = 233/337 (69%), Gaps = 31/337 (9%)

Query: 113 TLLVDEHAQLELVSLRPCFG-DYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPP 171
           TL+VDEH QLELVSLR C G  +  E DS                       EAS  +  
Sbjct: 512 TLVVDEHTQLELVSLRRCAGLGHDSEEDSG---------------------GEASEEEAG 550

Query: 172 ACL------SKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHR 225
           A L      S D++PD PD+ FSKKFLN+F++  SRSSS ESFGLFSC++N EE+EQTHR
Sbjct: 551 AALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHR 610

Query: 226 TIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHM 285
            +FRF+PRH DE EL+VDDP+LVE + +D+W+  +NMRTG RG F A+YA  V    + +
Sbjct: 611 AVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDL 670

Query: 286 AALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEIS 345
               ++  WV++F V+FLGSV+VP H+G+ +L AAMQKIAT R+LTVH  PP+SC LEIS
Sbjct: 671 LGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEIS 730

Query: 346 VRGVKIGVKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVF 405
           +RGVK+ +     +     +CSHFFQ+KNISF G HP+N+ YFGFITKH    RFACHVF
Sbjct: 731 LRGVKLSLSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVF 787

Query: 406 VSEDSTKALAESVGRAFQQFHKQFVEYTCPTEDIYLE 442
           VS++S + +A+SVGRAF +++++ + Y CPTEDIYLE
Sbjct: 788 VSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE 824



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 23/74 (31%), Positives = 36/74 (48%), Gaps = 4/74 (5%)

Query: 17  EDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNL 76
           +++EEDD++E        G  + + G +P S  +  + G      S +     RPTTL L
Sbjct: 86  DNEEEDDEDEEEEEEEEEGDGEGQEGGDPGS--EAPAPGPLIPSPSVEEPHKHRPTTLRL 143

Query: 77  FPQVQLSQDTLNNN 90
                 +QD+LNNN
Sbjct: 144 --TTLGAQDSLNNN 155


>gi|7706537 mitogen-activated protein kinase 8 interacting protein 2
           isoform 2 [Homo sapiens]
          Length = 797

 Score =  352 bits (902), Expect = 5e-97
 Identities = 179/337 (53%), Positives = 233/337 (69%), Gaps = 31/337 (9%)

Query: 113 TLLVDEHAQLELVSLRPCFG-DYSDESDSAIVYDNCVSVSSPYESAIGEEYEEASRPQPP 171
           TL+VDEH QLELVSLR C G  +  E DS                       EAS  +  
Sbjct: 485 TLVVDEHTQLELVSLRRCAGLGHDSEEDSG---------------------GEASEEEAG 523

Query: 172 ACL------SKDSTPDEPDVHFSKKFLNIFMSGRSRSSSAESFGLFSCIINREEQEQTHR 225
           A L      S D++PD PD+ FSKKFLN+F++  SRSSS ESFGLFSC++N EE+EQTHR
Sbjct: 524 AALLGGGQVSGDTSPDSPDLTFSKKFLNVFVNSTSRSSSTESFGLFSCLVNGEEREQTHR 583

Query: 226 TIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHM 285
            +FRF+PRH DE EL+VDDP+LVE + +D+W+  +NMRTG RG F A+YA  V    + +
Sbjct: 584 AVFRFIPRHPDELELDVDDPVLVEAEEDDFWFRGFNMRTGERGVFPAFYAHAVPGPAKDL 643

Query: 286 AALAKNSDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEIS 345
               ++  WV++F V+FLGSV+VP H+G+ +L AAMQKIAT R+LTVH  PP+SC LEIS
Sbjct: 644 LGSKRSPCWVERFDVQFLGSVEVPCHQGNGILCAAMQKIATARKLTVHLRPPASCDLEIS 703

Query: 346 VRGVKIGVKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVF 405
           +RGVK+ +     +     +CSHFFQ+KNISF G HP+N+ YFGFITKH    RFACHVF
Sbjct: 704 LRGVKLSLSGGGPE---FQRCSHFFQMKNISFCGCHPRNSCYFGFITKHPLLSRFACHVF 760

Query: 406 VSEDSTKALAESVGRAFQQFHKQFVEYTCPTEDIYLE 442
           VS++S + +A+SVGRAF +++++ + Y CPTEDIYLE
Sbjct: 761 VSQESMRPVAQSVGRAFLEYYQEHLAYACPTEDIYLE 797



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 23/74 (31%), Positives = 36/74 (48%), Gaps = 4/74 (5%)

Query: 17  EDDEEDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYRPKRPTTLNL 76
           +++EEDD++E        G  + + G +P S  +  + G      S +     RPTTL L
Sbjct: 59  DNEEEDDEDEEEEEEEEEGDGEGQEGGDPGS--EAPAPGPLIPSPSVEEPHKHRPTTLRL 116

Query: 77  FPQVQLSQDTLNNN 90
                 +QD+LNNN
Sbjct: 117 --TTLGAQDSLNNN 128


>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
           sapiens]
          Length = 304

 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 42/135 (31%), Positives = 66/135 (48%), Gaps = 8/135 (5%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCV-LEISVRGVKIGVKAD 356
           +  KFLGS +V   KG  V+  A++K+   R +          V L+IS+ GVKI     
Sbjct: 27  YNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKI----- 81

Query: 357 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKALAE 416
              E K  +  H  QL  ISF      + + F FI K    ++  C+VF SE   + +  
Sbjct: 82  --LEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITL 139

Query: 417 SVGRAFQQFHKQFVE 431
           ++G+AF   +++F+E
Sbjct: 140 TIGQAFDLAYRKFLE 154


>gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein
           isoform 1 [Homo sapiens]
          Length = 506

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 40/156 (25%), Positives = 70/156 (44%), Gaps = 21/156 (13%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPS----SCVLEISVRGVKIGV 353
           F  K++GS+ VP     V + AAM      RR+   F   +       + +SV GVK+ +
Sbjct: 32  FEAKYVGSLDVPRPNSRVEIVAAM------RRIRYEFKAKNIKKKKVSIMVSVDGVKVIL 85

Query: 354 KADDSQEAKGNKCSHFFQLK---------NISFRGYHPKNNKYFGFITKHLADHRFACHV 404
           K          K   + + K          I +  +  ++ K F +I +  A + F C+V
Sbjct: 86  KKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNV 145

Query: 405 FVSEDSTKA--LAESVGRAFQQFHKQFVEYTCPTED 438
           F S+  ++A  +  +VG+AF+  HK  +++T    D
Sbjct: 146 FKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNAD 181


>gi|50511947 cajalin 2 isoform b [Homo sapiens]
          Length = 510

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGVKAD 356
           ++  +LGS+ +   +G      A  K+ A  ++ T       + +L +S +GVK      
Sbjct: 312 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 366

Query: 357 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 414
              +A         +++NIS     P++   F +ITK L  +   CHVF + D   A  +
Sbjct: 367 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 424

Query: 415 AESVGRAFQ 423
             ++G+AF+
Sbjct: 425 ILTLGQAFE 433


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%)

Query: 298  FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGVKAD 356
            ++  +LGS+ +   +G      A  K+ A  ++ T       + +L +S +GVK      
Sbjct: 1062 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 1116

Query: 357  DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 414
               +A         +++NIS     P++   F +ITK L  +   CHVF + D   A  +
Sbjct: 1117 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 1174

Query: 415  AESVGRAFQ 423
              ++G+AF+
Sbjct: 1175 ILTLGQAFE 1183


>gi|10047134 cajalin 2 isoform c [Homo sapiens]
          Length = 414

 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 32/129 (24%), Positives = 59/129 (45%), Gaps = 10/129 (7%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKI-ATTRRLTVHFNPPSSCVLEISVRGVKIGVKAD 356
           ++  +LGS+ +   +G      A  K+ A  ++ T       + +L +S +GVK      
Sbjct: 228 YKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKF----- 282

Query: 357 DSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDSTKA--L 414
              +A         +++NIS     P++   F +ITK L  +   CHVF + D   A  +
Sbjct: 283 --IDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEI 340

Query: 415 AESVGRAFQ 423
             ++G+AF+
Sbjct: 341 ILTLGQAFE 349


>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
            1 [Homo sapiens]
          Length = 1134

 Score = 41.6 bits (96), Expect = 0.001
 Identities = 33/128 (25%), Positives = 57/128 (44%), Gaps = 12/128 (9%)

Query: 298  FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 357
            +   +LGS+ +   +G      A  K+   R+ T H     + +L I+ +GVK       
Sbjct: 942  YEANYLGSMLIKDLRGTESTQDACAKM---RKSTEHMKKIPTIILSITYKGVKF------ 992

Query: 358  SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVF--VSEDSTKALA 415
              +A         +++NIS     P++   F +ITK L      CHVF  V  + T  + 
Sbjct: 993  -IDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVFSTVDVNLTYEII 1051

Query: 416  ESVGRAFQ 423
             ++G+AF+
Sbjct: 1052 LTLGQAFE 1059


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 40.0 bits (92), Expect = 0.004
 Identities = 19/50 (38%), Positives = 27/50 (54%)

Query: 230 FVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVT 279
           F  +  DE  L+V D +L+  +  D WYE   +R G RG+F    A E+T
Sbjct: 800 FTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEIT 849


>gi|51988887 SH3 domain containing ring finger 1 [Homo sapiens]
          Length = 888

 Score = 39.3 bits (90), Expect = 0.007
 Identities = 19/54 (35%), Positives = 28/54 (51%)

Query: 227 IFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTK 280
           I+ + PR EDE EL   +  LV  + +D W++  +M T   G F   Y   VT+
Sbjct: 453 IYPYTPRKEDELELRKGEMFLVFERCQDGWFKGTSMHTSKIGVFPGNYVAPVTR 506



 Score = 35.4 bits (80), Expect = 0.10
 Identities = 16/49 (32%), Positives = 25/49 (51%)

Query: 222 QTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFF 270
           + HR +  + P+ E E EL+  D + V  + ED W++    R G  G F
Sbjct: 832 ERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLF 880


>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
          Length = 609

 Score = 38.9 bits (89), Expect = 0.009
 Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 14/126 (11%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 357
           F V++LG V+V   +G  V   A++K+    R +V        VL +S  G+++    DD
Sbjct: 80  FPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSV------KSVLWVSADGLRV---VDD 130

Query: 358 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 416
               K         ++ +SF       +K F +I +     R+ CH F++ +DS + L+ 
Sbjct: 131 ----KTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSH 186

Query: 417 SVGRAF 422
           +VG AF
Sbjct: 187 AVGCAF 192


>gi|150010572 SH3 domain containing ring finger 3 [Homo sapiens]
          Length = 882

 Score = 37.7 bits (86), Expect = 0.021
 Identities = 18/66 (27%), Positives = 33/66 (50%)

Query: 227 IFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMA 286
           ++ + P+  DE EL   +   V  + +D W++  ++RTG  G F   Y   V++ P   A
Sbjct: 472 LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGA 531

Query: 287 ALAKNS 292
              +N+
Sbjct: 532 GPPRNN 537



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 16/49 (32%), Positives = 25/49 (51%)

Query: 222 QTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFF 270
           + +R +  + P+ E E EL+  D + V  + ED WY+    R G  G F
Sbjct: 826 ERYRVVVSYPPQSEAEIELKEGDIVFVHKKREDGWYKGTLQRNGRTGLF 874


>gi|90403598 mesoderm posterior 2 homolog [Homo sapiens]
          Length = 397

 Score = 37.4 bits (85), Expect = 0.027
 Identities = 16/32 (50%), Positives = 20/32 (62%)

Query: 32  PGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 63
           P  GP +A++  E   +GQGQ QGQ QG G G
Sbjct: 166 PDRGPAEAQTQAEGQGQGQGQGQGQGQGQGQG 197



 Score = 32.7 bits (73), Expect = 0.68
 Identities = 15/34 (44%), Positives = 18/34 (52%)

Query: 30  RRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSG 63
           R P     +AE   +   +GQGQ QGQ QG G G
Sbjct: 168 RGPAEAQTQAEGQGQGQGQGQGQGQGQGQGQGQG 201


>gi|50959191 rho guanine nucleotide exchange factor 5 [Homo sapiens]
          Length = 1597

 Score = 37.0 bits (84), Expect = 0.036
 Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)

Query: 230  FVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEVTKEPEHMAALA 289
            + PR  DE  LE  D ++V  Q+ D W E   +  G RG+F     +E    PE  A   
Sbjct: 1521 YKPRENDELALEKADVVMVTQQSSDGWLEGVRLSDGERGWFPV-QQVEFISNPEVRAQNL 1579

Query: 290  KNSDWVDQFRVKFL 303
            K +  V   +++ +
Sbjct: 1580 KEAHRVKTAKLQLV 1593


>gi|54144629 numb homolog isoform 4 [Homo sapiens]
          Length = 592

 Score = 36.6 bits (83), Expect = 0.047
 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 14/126 (11%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 357
           F VK+LG V+V   +G  +   A++++  T +  V        VL +S  G+++      
Sbjct: 39  FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAV------KAVLWVSADGLRV------ 86

Query: 358 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 416
             + K         ++ +SF       ++ F +I +     R+ CH F++ +D+ + L+ 
Sbjct: 87  -VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSH 145

Query: 417 SVGRAF 422
           +VG AF
Sbjct: 146 AVGCAF 151


>gi|20070356 numb homolog isoform 3 [Homo sapiens]
          Length = 640

 Score = 36.6 bits (83), Expect = 0.047
 Identities = 30/126 (23%), Positives = 59/126 (46%), Gaps = 14/126 (11%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKIGVKADD 357
           F VK+LG V+V   +G  +   A++++  T +  V        VL +S  G+++      
Sbjct: 39  FPVKYLGHVEVDESRGMHICEDAVKRLKATGKKAV------KAVLWVSADGLRV------ 86

Query: 358 SQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDSTKALAE 416
             + K         ++ +SF       ++ F +I +     R+ CH F++ +D+ + L+ 
Sbjct: 87  -VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSH 145

Query: 417 SVGRAF 422
           +VG AF
Sbjct: 146 AVGCAF 151


>gi|50083291 amyloid beta A4 precursor protein-binding, family B,
           member 2 [Homo sapiens]
          Length = 736

 Score = 36.2 bits (82), Expect = 0.061
 Identities = 32/130 (24%), Positives = 64/130 (49%), Gaps = 12/130 (9%)

Query: 292 SDWVDQFRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHFNPPSSCVLEISVRGVKI 351
           ++ V +F V++LG + V    G  +L++A++ + T+       N      + ++V    +
Sbjct: 562 TELVQKFHVQYLGMLPVDKPVGMDILNSAIENLMTSS------NKEDWLSVNMNVADATV 615

Query: 352 GVKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVSEDST 411
            V ++ ++E    +C    +++ +SF G   K+   F FI     + RF CHVF  E + 
Sbjct: 616 TVISEKNEEEVLVEC----RVRFLSFMGVG-KDVHTFAFIMD-TGNQRFECHVFWCEPNA 669

Query: 412 KALAESVGRA 421
             ++E+V  A
Sbjct: 670 GNVSEAVQAA 679


>gi|155030230 sorbin and SH3 domain containing 3 isoform 1 [Homo
           sapiens]
          Length = 671

 Score = 36.2 bits (82), Expect = 0.061
 Identities = 18/55 (32%), Positives = 29/55 (52%)

Query: 224 HRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEV 278
           +R ++++ P++EDE EL   D + V  Q +D W+   + RT   G F   Y   V
Sbjct: 617 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 671


>gi|65301112 sorbin and SH3 domain containing 3 isoform 2 [Homo
           sapiens]
          Length = 329

 Score = 36.2 bits (82), Expect = 0.061
 Identities = 18/55 (32%), Positives = 29/55 (52%)

Query: 224 HRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIEV 278
           +R ++++ P++EDE EL   D + V  Q +D W+   + RT   G F   Y   V
Sbjct: 275 YRAMYQYRPQNEDELELREGDRVDVMQQCDDGWFVGVSRRTQKFGTFPGNYVAPV 329


>gi|18093112 ABT1-associated protein [Homo sapiens]
          Length = 851

 Score = 36.2 bits (82), Expect = 0.061
 Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 12/72 (16%)

Query: 9   ATGDTPGAEDDE-EDDDEERAARRPGAGPPKAESGQEPASRGQGQSQGQSQGPGSGDTYR 67
           A+GD  G+EDDE ED+DEE           K++SG + A           +G G+ +T  
Sbjct: 265 ASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLA-----------RGKGNIETSS 313

Query: 68  PKRPTTLNLFPQ 79
                T +LFP+
Sbjct: 314 EDEDDTADLFPE 325


>gi|67514036 SH3-domain kinase binding protein 1 isoform b [Homo
           sapiens]
          Length = 628

 Score = 35.4 bits (80), Expect = 0.10
 Identities = 18/68 (26%), Positives = 38/68 (55%), Gaps = 2/68 (2%)

Query: 218 EEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIE 277
           E + +  +  F ++P+++DE EL+V D + V  + E+ W+E   +  G  G F + +  E
Sbjct: 60  ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWE--GVLNGKTGMFPSNFIKE 117

Query: 278 VTKEPEHM 285
           ++ E + +
Sbjct: 118 LSGESDEL 125


>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
           sapiens]
          Length = 665

 Score = 35.4 bits (80), Expect = 0.10
 Identities = 18/68 (26%), Positives = 38/68 (55%), Gaps = 2/68 (2%)

Query: 218 EEQEQTHRTIFRFVPRHEDEPELEVDDPLLVELQAEDYWYEAYNMRTGARGFFTAYYAIE 277
           E + +  +  F ++P+++DE EL+V D + V  + E+ W+E   +  G  G F + +  E
Sbjct: 97  ERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWE--GVLNGKTGMFPSNFIKE 154

Query: 278 VTKEPEHM 285
           ++ E + +
Sbjct: 155 LSGESDEL 162


>gi|54144627 numb homolog isoform 2 [Homo sapiens]
          Length = 603

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 30/131 (22%), Positives = 59/131 (45%), Gaps = 13/131 (9%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHF-----NPPSSCVLEISVRGVKIG 352
           F VK+LG V+V   +G  +   A++++   R+    F           VL +S  G+++ 
Sbjct: 39  FPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRV- 97

Query: 353 VKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDST 411
                  + K         ++ +SF       ++ F +I +     R+ CH F++ +D+ 
Sbjct: 98  ------VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTG 151

Query: 412 KALAESVGRAF 422
           + L+ +VG AF
Sbjct: 152 ERLSHAVGCAF 162


>gi|54144625 numb homolog isoform 1 [Homo sapiens]
          Length = 651

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 30/131 (22%), Positives = 59/131 (45%), Gaps = 13/131 (9%)

Query: 298 FRVKFLGSVQVPYHKGDVVLSAAMQKIATTRRLTVHF-----NPPSSCVLEISVRGVKIG 352
           F VK+LG V+V   +G  +   A++++   R+    F           VL +S  G+++ 
Sbjct: 39  FPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRV- 97

Query: 353 VKADDSQEAKGNKCSHFFQLKNISFRGYHPKNNKYFGFITKHLADHRFACHVFVS-EDST 411
                  + K         ++ +SF       ++ F +I +     R+ CH F++ +D+ 
Sbjct: 98  ------VDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCFMAVKDTG 151

Query: 412 KALAESVGRAF 422
           + L+ +VG AF
Sbjct: 152 ERLSHAVGCAF 162


>gi|49640014 ubiquitin associated and SH3 domain containing, A short
           form [Homo sapiens]
          Length = 623

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 17/141 (12%)

Query: 222 QTHRTIFRFVPRHEDEPELEVDDPLLVEL----QAEDYWYEAYNMRTGARGFFTAYYAIE 277
           QT R +F++ P++ DE  L   D + V+     +A + W    + RTG RGF        
Sbjct: 241 QTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFL------- 293

Query: 278 VTKEPEHMAALAKNSD-WVDQFRVKFLGSVQVPYHK-GDVVLSAAMQKIATTRRLTVHFN 335
               PE+    A  SD WV      F  +  +   K G+     + + +  T R      
Sbjct: 294 ----PENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQ 349

Query: 336 PPSSCVLEISVRGVKIGVKAD 356
              + V   SV  V+ G + D
Sbjct: 350 ALQATVARKSVLVVRHGERVD 370


>gi|9507221 ubiquitin associated and SH3 domain containing, A long
           form [Homo sapiens]
          Length = 661

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 17/141 (12%)

Query: 222 QTHRTIFRFVPRHEDEPELEVDDPLLVEL----QAEDYWYEAYNMRTGARGFFTAYYAIE 277
           QT R +F++ P++ DE  L   D + V+     +A + W    + RTG RGF        
Sbjct: 279 QTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFL------- 331

Query: 278 VTKEPEHMAALAKNSD-WVDQFRVKFLGSVQVPYHK-GDVVLSAAMQKIATTRRLTVHFN 335
               PE+    A  SD WV      F  +  +   K G+     + + +  T R      
Sbjct: 332 ----PENYTDRASESDTWVKHRMYTFSLATDLNSRKDGEASSRCSGEFLPQTARSLSSLQ 387

Query: 336 PPSSCVLEISVRGVKIGVKAD 356
              + V   SV  V+ G + D
Sbjct: 388 ALQATVARKSVLVVRHGERVD 408


>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
          Length = 2752

 Score = 35.0 bits (79), Expect = 0.14
 Identities = 28/112 (25%), Positives = 44/112 (39%), Gaps = 8/112 (7%)

Query: 9   ATGDTPGAEDDEEDDDEERAARRPGAGPPKAESGQEP-------ASRGQGQSQGQSQGPG 61
           AT       +D++ D +E++A RP   P ++ +G EP       A R  G  Q  +  P 
Sbjct: 327 ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPL 386

Query: 62  SGDTYRPKRPTTLNLFPQVQLSQDTLNNNSLGKKY-KQPRPHHRSRHLHQQP 112
           S +   P    +         S + L  +S  +     P+P   SRH    P
Sbjct: 387 SQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSP 438


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.393 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,196,364
Number of Sequences: 37866
Number of extensions: 942680
Number of successful extensions: 6889
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 6462
Number of HSP's gapped (non-prelim): 459
length of query: 442
length of database: 18,247,518
effective HSP length: 105
effective length of query: 337
effective length of database: 14,271,588
effective search space: 4809525156
effective search space used: 4809525156
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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