Search of human proteins with 237757312

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
         (1295 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|237757312 synaptojanin 1 isoform c [Homo sapiens]                 2598   0.0  
gi|237757308 synaptojanin 1 isoform b [Homo sapiens]                 2587   0.0  
gi|237757310 synaptojanin 1 isoform a [Homo sapiens]                 2575   0.0  
gi|237757326 synaptojanin 1 isoform d [Homo sapiens]                 2491   0.0  
gi|26190608 synaptojanin 2 [Homo sapiens]                            1171   0.0  
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs...   211   3e-54
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso...   206   1e-52
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso...   206   1e-52
gi|190014578 suppressor of actin 1 [Homo sapiens]                     203   8e-52
gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens]      192   2e-48
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ...   170   9e-42
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ...   170   9e-42
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas...   159   2e-38
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap...   158   3e-38
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]     135   2e-31
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho...   133   1e-30
gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo sa...   130   1e-29
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H...   125   3e-28
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho...   125   3e-28
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     97   8e-20
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   94   1e-18
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   94   1e-18
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   94   1e-18
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    94   1e-18
gi|163965366 nascent polypeptide-associated complex alpha subuni...    92   2e-18
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre...    90   2e-17
gi|7706501 WW domain binding protein 11 [Homo sapiens]                 86   3e-16
gi|116284392 mucin 2 precursor [Homo sapiens]                          85   4e-16
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    85   5e-16
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [...    84   1e-15

>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
          Length = 1295

 Score = 2598 bits (6733), Expect = 0.0
 Identities = 1295/1295 (100%), Positives = 1295/1295 (100%)

Query: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60
            MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY
Sbjct: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60

Query: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120
            GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR
Sbjct: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120

Query: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180
            KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL
Sbjct: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180

Query: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240
            RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD
Sbjct: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240

Query: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300
            DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN
Sbjct: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300

Query: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360
            LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD
Sbjct: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360

Query: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420
            YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR
Sbjct: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420

Query: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 480
            FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL
Sbjct: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 480

Query: 481  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 540
            LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW
Sbjct: 481  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 540

Query: 541  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 600
            NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI
Sbjct: 541  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 600

Query: 601  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 660
            VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT
Sbjct: 601  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 660

Query: 661  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 720
            GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF
Sbjct: 661  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 720

Query: 721  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 780
            SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF
Sbjct: 721  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 780

Query: 781  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 840
            APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT
Sbjct: 781  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 840

Query: 841  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 900
            WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI
Sbjct: 841  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 900

Query: 901  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 960
            KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL
Sbjct: 901  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 960

Query: 961  NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1020
            NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA
Sbjct: 961  NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1020

Query: 1021 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1080
            EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS
Sbjct: 1021 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1080

Query: 1081 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1140
            AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK
Sbjct: 1081 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1140

Query: 1141 EFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASA 1200
            EFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASA
Sbjct: 1141 EFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASA 1200

Query: 1201 GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGP 1260
            GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGP
Sbjct: 1201 GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGP 1260

Query: 1261 QPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG 1295
            QPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG
Sbjct: 1261 QPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG 1295


>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
          Length = 1350

 Score = 2587 bits (6706), Expect = 0.0
 Identities = 1295/1311 (98%), Positives = 1295/1311 (98%), Gaps = 16/1311 (1%)

Query: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60
            MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY
Sbjct: 40   MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 99

Query: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120
            GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR
Sbjct: 100  GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 159

Query: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180
            KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL
Sbjct: 160  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 219

Query: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240
            RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD
Sbjct: 220  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 279

Query: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300
            DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN
Sbjct: 280  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 339

Query: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360
            LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD
Sbjct: 340  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 399

Query: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420
            YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR
Sbjct: 400  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 459

Query: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 480
            FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL
Sbjct: 460  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 519

Query: 481  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 540
            LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW
Sbjct: 520  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 579

Query: 541  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 600
            NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI
Sbjct: 580  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 639

Query: 601  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 660
            VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT
Sbjct: 640  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 699

Query: 661  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 720
            GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF
Sbjct: 700  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 759

Query: 721  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 780
            SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF
Sbjct: 760  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 819

Query: 781  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 840
            APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT
Sbjct: 820  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 879

Query: 841  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 900
            WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI
Sbjct: 880  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 939

Query: 901  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 960
            KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL
Sbjct: 940  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 999

Query: 961  NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1020
            NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA
Sbjct: 1000 NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1059

Query: 1021 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1080
            EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS
Sbjct: 1060 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1119

Query: 1081 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1140
            AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK
Sbjct: 1120 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1179

Query: 1141 EFG----------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1184
            EFG                APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP
Sbjct: 1180 EFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1239

Query: 1185 RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1244
            RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL
Sbjct: 1240 RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1299

Query: 1245 QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG 1295
            QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG
Sbjct: 1300 QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPSG 1350


>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
          Length = 1612

 Score = 2575 bits (6674), Expect = 0.0
 Identities = 1289/1305 (98%), Positives = 1289/1305 (98%), Gaps = 16/1305 (1%)

Query: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60
            MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY
Sbjct: 40   MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 99

Query: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120
            GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR
Sbjct: 100  GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 159

Query: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180
            KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL
Sbjct: 160  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 219

Query: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240
            RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD
Sbjct: 220  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 279

Query: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300
            DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN
Sbjct: 280  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 339

Query: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360
            LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD
Sbjct: 340  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 399

Query: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420
            YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR
Sbjct: 400  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 459

Query: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 480
            FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL
Sbjct: 460  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKLKDGARSVTRTIQNNFFDSSKQEAIDVLL 519

Query: 481  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 540
            LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW
Sbjct: 520  LGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCVGTW 579

Query: 541  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 600
            NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI
Sbjct: 580  NVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNI 639

Query: 601  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 660
            VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT
Sbjct: 640  VSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKT 699

Query: 661  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 720
            GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF
Sbjct: 700  GMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLF 759

Query: 721  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 780
            SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF
Sbjct: 760  SHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTF 819

Query: 781  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 840
            APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT
Sbjct: 820  APTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYT 879

Query: 841  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 900
            WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI
Sbjct: 880  WTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSI 939

Query: 901  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 960
            KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL
Sbjct: 940  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELL 999

Query: 961  NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1020
            NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA
Sbjct: 1000 NRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA 1059

Query: 1021 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1080
            EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS
Sbjct: 1060 EVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPS 1119

Query: 1081 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1140
            AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK
Sbjct: 1120 AQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRK 1179

Query: 1141 EFG----------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1184
            EFG                APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP
Sbjct: 1180 EFGGIGAPPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1239

Query: 1185 RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1244
            RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL
Sbjct: 1240 RAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1299

Query: 1245 QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1289
            QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ
Sbjct: 1300 QEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1344


>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
          Length = 1526

 Score = 2491 bits (6457), Expect = 0.0
 Identities = 1255/1292 (97%), Positives = 1255/1292 (97%), Gaps = 37/1292 (2%)

Query: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60
            MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY
Sbjct: 1    MAFSKGFRIYHKLDPPPFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDAY 60

Query: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120
            GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR
Sbjct: 61   GLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEVR 120

Query: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180
            KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL
Sbjct: 121  KVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTTDNRFFWNQSLHLHLKHYGVNCDDWLL 180

Query: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240
            RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD
Sbjct: 181  RLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLD 240

Query: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300
            DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN
Sbjct: 241  DSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVN 300

Query: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360
            LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD
Sbjct: 301  LLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD 360

Query: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420
            YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR
Sbjct: 361  YGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420

Query: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQEAID 477
            FQEVFRSMWSVNGDSISKIYAGTGALEGKAK   LKDGARSVTRTIQNNFFDSSKQEAID
Sbjct: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGKAKAGKLKDGARSVTRTIQNNFFDSSKQEAID 480

Query: 478  VLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCV 537
            VLLLGNTLNSDLADKARALLTTGSLR        ASSKVLKSMCENFYKYSKPKKIRVCV
Sbjct: 481  VLLLGNTLNSDLADKARALLTTGSLR--------ASSKVLKSMCENFYKYSKPKKIRVCV 532

Query: 538  GTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNA 597
            GTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNA
Sbjct: 533  GTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNA 592

Query: 598  GNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDT 657
            GNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDT
Sbjct: 593  GNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDT 652

Query: 658  VKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGR 717
            VKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGR
Sbjct: 653  VKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGR 712

Query: 718  MLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGK 777
            MLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGK
Sbjct: 713  MLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGK 772

Query: 778  VTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKI 837
            VTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKI
Sbjct: 773  VTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKI 832

Query: 838  LYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVL 897
            LYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVL
Sbjct: 833  LYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVL 892

Query: 898  VSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGK 957
            VSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGK
Sbjct: 893  VSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGK 952

Query: 958  ELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDD 1017
            ELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDD
Sbjct: 953  ELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDD 1012

Query: 1018 YSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPG 1077
            YSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPG
Sbjct: 1013 YSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPG 1072

Query: 1078 PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAP 1137
            PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS       
Sbjct: 1073 PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPS------- 1125

Query: 1138 TRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1197
                               GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR
Sbjct: 1126 -------------------GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1166

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ 1257
            ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ
Sbjct: 1167 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ 1226

Query: 1258 SGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1289
            SGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ
Sbjct: 1227 SGPQPNLETPPQPPPRSRSSHSLPSEASSQPQ 1258


>gi|26190608 synaptojanin 2 [Homo sapiens]
          Length = 1496

 Score = 1171 bits (3029), Expect = 0.0
 Identities = 628/1341 (46%), Positives = 868/1341 (64%), Gaps = 81/1341 (6%)

Query: 1    MAFSKGFRIYHKLDPP-PFSLIVETRHKEECLMFESGAVAVLSSAEKEAIKGTYSKVLDA 59
            MA SKG R+  +L      S+++E R +++CL+FE+G VA L+  EKE IKG Y K+ DA
Sbjct: 1    MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA 60

Query: 60   YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLRIDSSDEDRISEV 119
            YG LG LRL  G T L +LVLVTGC SVG+I ++E++++T+T+F  L+ ++ +E+R+  +
Sbjct: 61   YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL 120

Query: 120  RKVLNSGNFYFAWSASGISLDLSLNAHRSMQEQTT-DNRFFWNQSLHLHLKHYGVNCDDW 178
            +K+L+SG FYF+W   G   DL++   +   + +   N FFWNQ LH+ L+ + V+C DW
Sbjct: 121  KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW 180

Query: 179  LLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY 238
            LL+++CG V IRT+YA+HKQAKACL+SR+SCER GTRF+ RG NDDGHV+NFVETEQ++Y
Sbjct: 181  LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY 240

Query: 239  LDDSVSSFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQII 298
            +DD VSSF+QIRGSVPLFWEQPGLQVGSH +R+ RG EANAPAFDRH   LK  YG+Q++
Sbjct: 241  MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV 300

Query: 299  VNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQ-K 357
            VNLLGS+ GE +L++AF+  L AS HA D  M+NFD+HQ  KGGK EKL ++L+PQ++  
Sbjct: 301  VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH 360

Query: 358  FLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQL 417
            + D+  F    +   R Q GT+R NCLDCLDRTN+VQ+F+ LE+L  QL+ LGL+ KP +
Sbjct: 361  WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKP-I 419

Query: 418  VTRFQEVFRSMWSVNGDSISKIYAGTGALEGKAK---LKDGARSVTRTIQNNFFDSSKQE 474
            V RF E F++MWS+NG S+SK++ G+ ALEGKAK   LKDGARS++RTIQ+NFFD  KQE
Sbjct: 420  VDRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQE 479

Query: 475  AIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIR 534
            AI +LL+G+    ++ADK   LL + +L V+         ++LK+M E   +++  K+IR
Sbjct: 480  AIKLLLVGDVYGEEVADKGGMLLDSTALLVTP--------RILKAMTERQSEFTNFKRIR 531

Query: 535  VCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVE 594
            + +GTWNVNGGKQFRS   +   LTDWLLD+P+L+G  + QD  S P DIFA+GFEEMVE
Sbjct: 532  IAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDD-SSPADIFAVGFEEMVE 590

Query: 595  LNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVA 654
            L+AGNIV+ASTTN+K+W  +LQK ISR ++Y+LL S QLVGVCL++F+RP H PFIRDVA
Sbjct: 591  LSAGNIVNASTTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVA 650

Query: 655  VDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFP 714
            +DTVKTGMGG  GNKGAV IR  FH+TS CF+CSH  AGQSQVKERNED+ EI +KL FP
Sbjct: 651  IDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFP 710

Query: 715  MGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 774
            MGR +FSHDYVFWCGDFNYRIDL  EEV   +++Q+W  L+  DQL  QK++G++F+ F 
Sbjct: 711  MGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFH 770

Query: 775  EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDE 834
            EG + F PTYKYD+ S  YDTS+KCRTPAWTDRVLW R+K PFD++A +L+LL++    +
Sbjct: 771  EGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVD 830

Query: 835  SKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDG 894
            +K+ +TW+PG L +YGRAEL+ SDHRPV+A++++++ EV+   R+ +++EV + QGP D 
Sbjct: 831  TKVRHTWSPGALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDA 890

Query: 895  TVLVSIKS-SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLS 953
            TV+V+++S +L E N F + L  EL+Q   S+G ++L+R  + +M VTF +  SAL+VL 
Sbjct: 891  TVVVNLQSPTLEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLD 950

Query: 954  LNGKELLNRTITIALKSPDWIKNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEG 1013
            ++G ++  R + I  K+ DW+K L EE+  ++ S+A  S T+++ L E+       D E 
Sbjct: 951  VDGMKVKGRAVKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYES 1010

Query: 1014 DVDDYSAEVEELLPQHLQPS-SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP 1072
            + D    + + L+ +  QP  S S LG                +S+ P P+    PS++P
Sbjct: 1011 EGDILEDDEDYLVDEFNQPGVSDSELG-------------GDDLSDVPGPTALAPPSKSP 1057

Query: 1073 SRTPGPPSAQSSPIDAQPATPLPQKDPAQPL-EPKRPPPPRPVAPPTR---PAPPQRPPP 1128
            + T      +  P     A  +  K   + + E +   P R ++ P R   P PPQRPPP
Sbjct: 1058 ALT----KKKQHPTYKDDADLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPP 1113

Query: 1129 PSGARSPAPTRKEFGAPKSPGTTRKDNI--------GRSQPSPQAGLAGPGPAGYSTARP 1180
            P+G       +    A  S GT  + +I        G  Q  P+A      P      + 
Sbjct: 1114 PTGL---MVKKSASDASISSGTHGQYSILQTARLLPGAPQQPPKARTGISKPYNVKQIKT 1170

Query: 1181 TIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPP 1240
            T    A         AR  A   + E+ S  +     ++  PEP  P AA P     PP 
Sbjct: 1171 TNAQEAEAAIRCLLEARGGA---SEEALSAVAPRDLEASSEPEP-TPGAAKPETPQAPPL 1226

Query: 1241 AQRLQEPLVP---------------------------VAAPMPQSGPQPNLETPPQPPPR 1273
              R   P VP                              P   S   P + T P+ PP 
Sbjct: 1227 LPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPV 1286

Query: 1274 SRSSHSLPSEASSQPQQEQPS 1294
             +     P +A+ +P   +P+
Sbjct: 1287 PKPRTFQPGKAAERPSHRKPA 1307



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 52/221 (23%), Positives = 78/221 (35%), Gaps = 27/221 (12%)

Query: 1043 SSSPRTSP-CQSPTISEGPVPSLPIRPSRAPSRTPG--PPSAQSSPIDAQPATPLPQKD- 1098
            SS P  +P    P   + P    P+ P R P R P    P+ + +     P     Q+  
Sbjct: 1206 SSEPEPTPGAAKPETPQAP----PLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQTV 1261

Query: 1099 --PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNI 1156
                 P E     PP   AP   P P  R   P G  +  P+ ++  + ++P        
Sbjct: 1262 HFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQP-GKAAERPSHRKPASDEAP-------- 1312

Query: 1157 GRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA--SAGRLTPESQSKTSET 1214
                  P AG + P P       P +PPR    +    H +   S  +L       +S++
Sbjct: 1313 ------PGAGASVPPPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDS 1366

Query: 1215 SKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPM 1255
              G       + PQ  F   SS   P     + + P AAP+
Sbjct: 1367 PSGHPPAAGTVFPQGDFLSTSSATSPDSDGTKAMKPEAAPL 1407


>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
           [Homo sapiens]
          Length = 913

 Score =  211 bits (538), Expect = 3e-54
 Identities = 138/416 (33%), Positives = 214/416 (51%), Gaps = 63/416 (15%)

Query: 483 NTLNSDLADKARALLTTGSLRVSEQTLQSASSK--VLKS-MCENFYKYSKPKKIRVCVGT 539
           N   S++ D  R+   T S +    ++Q    +  ++KS + +    Y+  +  R   GT
Sbjct: 212 NKSKSEITDMVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGT 271

Query: 540 WNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 599
           +NVNG           + L  WL +     GIQ          D++ +GF+E+ +L+   
Sbjct: 272 YNVNGQSP-------KECLRLWLSN-----GIQA--------PDVYCVGFQEL-DLSKEA 310

Query: 600 IVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVK 659
                T  ++ W   + + +  D KY  +   +LVG+ L ++++ +HA +I +V  +TV 
Sbjct: 311 FFFHDTPKEEEWFKAVSEGLHPDAKYAKVKLIRLVGIMLLLYVKQEHAAYISEVEAETVG 370

Query: 660 TGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSF------ 713
           TG+ G  GNKG VAIR  FH TS+C V SH AA   + + RN+D+ +I  ++ F      
Sbjct: 371 TGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKDICSRMQFCQPDPS 430

Query: 714 --PMGRMLFSHDYVFWCGDFNYRID-LPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVF 770
             P+   + +HD + W GD NYRI+ L  E+VK+LI ++++  L A DQL  Q  A  VF
Sbjct: 431 LPPL--TISNHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYDQLKIQVAAKTVF 488

Query: 771 RGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNAS 830
            GF EG++TF PTYKYD  SDD+DTSEKCR PAW DR+LW+ +           ++   S
Sbjct: 489 EGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK-----------NITQLS 537

Query: 831 FQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEERQNIYKEVI 886
           +Q                     LKTSDH+PV ++ DI +  V  E  +   +E++
Sbjct: 538 YQ-----------------SHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIV 576


>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
           isoform b [Homo sapiens]
          Length = 893

 Score =  206 bits (524), Expect = 1e-52
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272

Query: 586 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 645
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331

Query: 646 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 705
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391

Query: 706 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 758
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451

Query: 759 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 818
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504

Query: 819 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 878
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543

Query: 879 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 906
           + ++++ + +    +   L S++ S  E
Sbjct: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571


>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
           isoform a [Homo sapiens]
          Length = 901

 Score =  206 bits (524), Expect = 1e-52
 Identities = 125/388 (32%), Positives = 194/388 (50%), Gaps = 56/388 (14%)

Query: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
           +Y   +  R  VGTWNVNG          +  L  WL   P              P DI+
Sbjct: 233 EYVNIQTFRFFVGTWNVNGQSP-------DSGLEPWLNCDPN-------------PPDIY 272

Query: 586 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 645
            IGF+E+ +L+        +  ++ W++ +++ +    KY  +   +LVG+ L +F R  
Sbjct: 273 CIGFQEL-DLSTEAFFYFESVKEQEWSMAVERGLHSKAKYKKVQLVRLVGMMLLIFARKD 331

Query: 646 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 705
              +IRD+A +TV TG+ G  GNKG VA+R +FH T+ C V SH AA     + RN+D+ 
Sbjct: 332 QCRYIRDIATETVGTGIMGKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYK 391

Query: 706 EIARKLSFPMGRM------LFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGD 758
           +I  ++SF +         +  H+ V W GD NYR+ +P+  EVK LI +++   L+  D
Sbjct: 392 DICARMSFVVPNQTLPQLNIMKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFD 451

Query: 759 QLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRRKWPFD 818
           QL  Q+   + F  F EG++ F PTYKYD  +D +D+S KCR PAW DR+LWR       
Sbjct: 452 QLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWR------- 504

Query: 819 RSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDIFEVEAEER 878
               +++ LN                   +    ELKTSDH+PV AL  I +  V+    
Sbjct: 505 --GTNVNQLN-------------------YRSHMELKTSDHKPVSALFHIGVKVVDERRY 543

Query: 879 QNIYKEVIAVQGPPDGTVLVSIKSSLPE 906
           + ++++ + +    +   L S++ S  E
Sbjct: 544 RKVFEDSVRIMDRMENDFLPSLELSRRE 571


>gi|190014578 suppressor of actin 1 [Homo sapiens]
          Length = 587

 Score =  203 bits (517), Expect = 8e-52
 Identities = 147/454 (32%), Positives = 237/454 (52%), Gaps = 40/454 (8%)

Query: 60  YGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFISLR------IDSSDE 113
           +G+LG + L  G+    YL+++T  + VG+     V++ T  + +S +       D   +
Sbjct: 58  FGILGTIHLVAGN----YLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQ 113

Query: 114 DR---ISEVRKVLNSGNFYFAWSASGI-SLDLSLNAHRSMQEQT----TDNRFFWNQSLH 165
           D    ++ +  VLN   FYF+ +     +L    N     QE +     D RF WN  L 
Sbjct: 114 DNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSPEFQEMSLLERADQRFVWNGHLL 173

Query: 166 LHLKHYGVNCDDWLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDG 225
             L         + L ++ G + + +     K     LISR SC RAG R+ VRG + +G
Sbjct: 174 RELSAQP-EVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEG 232

Query: 226 HVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQ-PGLQVGSHRVRMSRGFEANAPAFDR 284
           H ANFVETEQ+V+ + S +SF+Q RGS+P+FW Q P L+     +        +   F R
Sbjct: 233 HAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKY--KPLPQISKVANHMDGFQR 290

Query: 285 HFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKA 344
           HF +   +YGKQ+I+NL+  K  E  L + F + + +S  +  ++ + FD+H+  K  + 
Sbjct: 291 HFDSQVIIYGKQVIINLINQKGSEKPLEQTFAT-MVSSLGSGMMRYIAFDFHKECKNMRW 349

Query: 345 EKLHSVLKPQVQKFLDYGFFYF--NGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEML 402
           ++L S+L  QV +  D   ++   +  +V   Q G  R+NC+DCLDRTN +Q+ L    L
Sbjct: 350 DRL-SILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSL 408

Query: 403 AKQLEALG---LAEKPQLVTRFQEVFRSMWSVNGDSISKIYAGTGALE------GK---- 449
             QL+ LG   + +K +    F++++++ W+ N ++ +K YAGTGAL+      GK    
Sbjct: 409 QAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHL 468

Query: 450 AKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGN 483
             + DG  S+ R  +NNF D  +Q++ID L LGN
Sbjct: 469 GLIMDGWNSMIRYYKNNFSDGFRQDSID-LFLGN 501


>gi|7662414 inositol polyphosphate-5-phosphatase F [Homo sapiens]
          Length = 1132

 Score =  192 bits (487), Expect = 2e-48
 Identities = 129/416 (31%), Positives = 208/416 (50%), Gaps = 53/416 (12%)

Query: 119 VRKVLNSGNFYFAWSASGISLDLSLNAHRSMQE--------QTTDNRFFWNQSLHLHLKH 170
           ++  ++S +FY++     ++ DL+ +  R            Q  D+RFFWN+ +   L  
Sbjct: 167 LKMFMDSESFYYS-----LTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTE 221

Query: 171 YGV-NCDDWLLRLMCGGVEIRTIYA-------------------------AHKQAKACLI 204
            G  + D W++ ++ G V+I  +                            H +    LI
Sbjct: 222 IGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALI 281

Query: 205 SRLSCERAGTRFNVRGTNDDGHVANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQV 264
           SR S  RAG R+  RG + +G+VAN+VETEQ++++ +   SF+Q RGSVP+FW Q G + 
Sbjct: 282 SRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRY 341

Query: 265 GSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLGSKEGEHMLSKAFQSHLKASEH 324
            + R R+ R  +     F  HF    N+Y KQ+I+NL+     E ++  A+   +    +
Sbjct: 342 -NPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNN 400

Query: 325 AADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLDYGFFYFNGSEVQRCQSGTVRTNCL 384
            + +  V+FD+H+  +G K E + ++        LD  + + + + V   Q G  R NC+
Sbjct: 401 -SHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCM 459

Query: 385 DCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQ-LVTRFQEVFRSMWSVNGDSISKIYAGT 443
           DCLDRTN VQA +   ++ +QL+ LG+    Q L  +   +++ MW+ NGDSIS+ YAGT
Sbjct: 460 DCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGT 519

Query: 444 GALEG----------KAKLKDGARSVTRTIQNNFFDSSKQEAIDVLLLGNTLNSDL 489
            AL+G             +KDG  S  R   N F D+ +Q  ID L+ G  +  DL
Sbjct: 520 AALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVID-LMQGIPVTEDL 574


>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
            sapiens]
          Length = 1188

 Score =  170 bits (430), Expect = 9e-42
 Identities = 204/827 (24%), Positives = 326/827 (39%), Gaps = 151/827 (18%)

Query: 515  KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 574
            ++L+ M     +  +P  I + +GTWN+      + I       T W L   K  G    
Sbjct: 385  QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 435

Query: 575  QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 632
                  P DI+ IG +E               ++K W   L+ ++       +  +A   
Sbjct: 436  DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 483

Query: 633  LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
            L  + + V  +P+H   I  +  D VKTG+    GNKGAV +  +F+ TSL FV SH  +
Sbjct: 484  LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 543

Query: 693  GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 744
            G  +   RN++++ I R L+     +     +H   ++FW GD NYR+DLP    E + +
Sbjct: 544  GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 603

Query: 745  LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 797
             I+QQ +  L++ DQL+ ++   +VF  F E ++TFAPTY+++ L  D Y       T  
Sbjct: 604  KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 663

Query: 798  KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 857
            K   P+W DRVLW  + +P       + ++  S+   S I+                 TS
Sbjct: 664  KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 698

Query: 858  DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 917
            DH PV A  +  +      +        +  QG  +     +   +  +  F+ +     
Sbjct: 699  DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 754

Query: 918  LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 977
             L+ F    E       E ++ V F E    L  +  + + LL++ I I++KS D  ++ 
Sbjct: 755  CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 814

Query: 978  EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1032
             E    + LE     LP  T  T  G   E+   F  E  +     +  E L   +  + 
Sbjct: 815  GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 871

Query: 1033 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1069
              SSG  T  S            + R  PC   +I+E            GP   L ++ +
Sbjct: 872  DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 931

Query: 1070 RAPSRTPGPPSAQSSPIDAQPATPL----PQKDPAQ-PLEPKR----------PPP---- 1110
             +P + P   S    P D+ P  P     P   P Q P+ PK+          PP     
Sbjct: 932  LSPDQQPTAWSYDQPPKDS-PLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQES 990

Query: 1111 -------------PRPVAPPTRPAPPQRPPPPSGARSPAPT-RKEFGAPKSPGTTRKDNI 1156
                         P+   P T+P   + P   S +  P P  RK+  +PK P   RK+  
Sbjct: 991  RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMP---RKE-- 1045

Query: 1157 GRSQPSPQAGLAGP---------GPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
                P P+ G+  P            G    +    PR    +   S    +AG    + 
Sbjct: 1046 --PPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQG 1103

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1254
            + KT  +S+       P+KP  +   Q + P P  R   P +PV +P
Sbjct: 1104 KPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR---PPLPVKSP 1147



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 34/143 (23%), Positives = 48/143 (33%), Gaps = 25/143 (17%)

Query: 1050 PCQSPTISEGPVPSLPIRPSRAPSRTPGPP-----------SAQSSPIDAQPATPLPQKD 1098
            PC  P I     PS+ +  ++   R  GP            +  SS           Q  
Sbjct: 1048 PCPEPGILS---PSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGK 1104

Query: 1099 PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE--FGAPKSPGTTRKDNI 1156
            P  P+  + P P +    P+R    Q+ PP    R P P +         S G   +DN 
Sbjct: 1105 PKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNT 1164

Query: 1157 -----GRSQPSPQAGLAGPGPAG 1174
                 G+ +P        PGP G
Sbjct: 1165 ELPHHGKHRPEE----GPPGPLG 1183


>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
            sapiens]
          Length = 1189

 Score =  170 bits (430), Expect = 9e-42
 Identities = 204/827 (24%), Positives = 326/827 (39%), Gaps = 151/827 (18%)

Query: 515  KVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEF 574
            ++L+ M     +  +P  I + +GTWN+      + I       T W L   K  G    
Sbjct: 386  QLLQQMKNKHSEQPEPDMITIFIGTWNMGNAPPPKKI-------TSWFLS--KGQGKTRD 436

Query: 575  QDKRSKPTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNK--YVLLASEQ 632
                  P DI+ IG +E               ++K W   L+ ++       +  +A   
Sbjct: 437  DSADYIPHDIYVIGTQE------------DPLSEKEWLEILKHSLQEITSVTFKTVAIHT 484

Query: 633  LVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAA 692
            L  + + V  +P+H   I  +  D VKTG+    GNKGAV +  +F+ TSL FV SH  +
Sbjct: 485  LWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNKGAVGVSFMFNGTSLGFVNSHLTS 544

Query: 693  GQSQVKERNEDFIEIARKLSF---PMGRMLFSH--DYVFWCGDFNYRIDLPN---EEVKE 744
            G  +   RN++++ I R L+     +     +H   ++FW GD NYR+DLP    E + +
Sbjct: 545  GSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTHLFWFGDLNYRVDLPTWEAETIIQ 604

Query: 745  LIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYD-LFSDDY------DTSE 797
             I+QQ +  L++ DQL+ ++   +VF  F E ++TFAPTY+++ L  D Y       T  
Sbjct: 605  KIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFAPTYRFERLTRDKYAYTKQKATGM 664

Query: 798  KCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTS 857
            K   P+W DRVLW  + +P       + ++  S+   S I+                 TS
Sbjct: 665  KYNLPSWCDRVLW--KSYPL------VHVVCQSYGSTSDIM-----------------TS 699

Query: 858  DHRPVVALIDIDIFEVEAEERQNIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDE 917
            DH PV A  +  +      +        +  QG  +     +   +  +  F+ +     
Sbjct: 700  DHSPVFATFEAGVTSQFVSKNG---PGTVDSQGQIEFLRCYATLKTKSQTKFYLE-FHSS 755

Query: 918  LLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSLNGKELLNRTITIALKSPDWIKNL 977
             L+ F    E       E ++ V F E    L  +  + + LL++ I I++KS D  ++ 
Sbjct: 756  CLESFVKSQEGENEEGSEGELVVKFGETLPKLKPIISDPEYLLDQHILISIKSSDSDESY 815

Query: 978  EE---EMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHL--QP 1032
             E    + LE     LP  T  T  G   E+   F  E  +     +  E L   +  + 
Sbjct: 816  GEGCIALRLEATETQLPIYTPLTHHG---ELTGHFQGEIKLQTSQGKTREKLYDFVKTER 872

Query: 1033 SSSSGLGTSPS-----------SSPRTSPCQSPTISE------------GPVPSLPIRPS 1069
              SSG  T  S            + R  PC   +I+E            GP   L ++ +
Sbjct: 873  DESSGPKTLKSLTSHDPMKQWEVTSRAPPCSGSSITEIINPNYMGVGPFGPPMPLHVKQT 932

Query: 1070 RAPSRTPGPPSAQSSPIDAQPATPL----PQKDPAQ-PLEPKR----------PPP---- 1110
             +P + P   S    P D+ P  P     P   P Q P+ PK+          PP     
Sbjct: 933  LSPDQQPTAWSYDQPPKDS-PLGPCRGESPPTPPGQPPISPKKFLPSTANRGLPPRTQES 991

Query: 1111 -------------PRPVAPPTRPAPPQRPPPPSGARSPAPT-RKEFGAPKSPGTTRKDNI 1156
                         P+   P T+P   + P   S +  P P  RK+  +PK P   RK+  
Sbjct: 992  RPSDLGKNAGDTLPQEDLPLTKPEMFENPLYGSLSSFPKPAPRKDQESPKMP---RKE-- 1046

Query: 1157 GRSQPSPQAGLAGP---------GPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
                P P+ G+  P            G    +    PR    +   S    +AG    + 
Sbjct: 1047 --PPPCPEPGILSPSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQG 1104

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1254
            + KT  +S+       P+KP  +   Q + P P  R   P +PV +P
Sbjct: 1105 KPKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPR---PPLPVKSP 1148



 Score = 31.6 bits (70), Expect = 5.2
 Identities = 34/143 (23%), Positives = 48/143 (33%), Gaps = 25/143 (17%)

Query: 1050 PCQSPTISEGPVPSLPIRPSRAPSRTPGPP-----------SAQSSPIDAQPATPLPQKD 1098
            PC  P I     PS+ +  ++   R  GP            +  SS           Q  
Sbjct: 1049 PCPEPGILS---PSIVLTKAQEADRGEGPGKQVPAPRLRSFTCSSSAEGRAAGGDKSQGK 1105

Query: 1099 PAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE--FGAPKSPGTTRKDNI 1156
            P  P+  + P P +    P+R    Q+ PP    R P P +         S G   +DN 
Sbjct: 1106 PKTPVSSQAPVPAKRPIKPSRSEINQQTPPTPTPRPPLPVKSPAVLHLQHSKGRDYRDNT 1165

Query: 1157 -----GRSQPSPQAGLAGPGPAG 1174
                 G+ +P        PGP G
Sbjct: 1166 ELPHHGKHRPEE----GPPGPLG 1184


>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A
            [Homo sapiens]
          Length = 638

 Score =  159 bits (401), Expect = 2e-38
 Identities = 175/642 (27%), Positives = 269/642 (41%), Gaps = 97/642 (15%)

Query: 530  PKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGF 589
            P + R+ V TWNV         A     +T  L     L G  +     S   D+ AIG 
Sbjct: 52   PSEPRITVVTWNVG-------TAMPPDDVTSLL----HLGGGDD-----SDGADMIAIGL 95

Query: 590  EEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQHAPF 649
            +E+  +    +  A  T+Q  W+      +   N +VL++S ++ GV L +F +  H PF
Sbjct: 96   QEVNSMLNKRLKDALFTDQ--WSELFMDALGPFN-FVLVSSVRMQGVILLLFAKYYHLPF 152

Query: 650  IRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIAR 709
            +RDV  D  +TG+GG  GNKG V++R+      LCF+  H  A   + ++R ++F  I  
Sbjct: 153  LRDVQTDCTRTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILS 212

Query: 710  KLSF--PMGRMLFSHDYVFWCGDFNYRIDLPN-EEVKELIRQQNWDSLIAGDQLINQKNA 766
               F  P  + +  HD VFW GD N+RI+  +   VK  I       L   DQL   KN 
Sbjct: 213  LQQFQGPGAQGILDHDLVFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNT 272

Query: 767  GQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRR-----KWPFDRSA 821
              + +GF EG + FAPT+K+D+ ++ YDTS K R PAWTDR+LW+ +       P  R +
Sbjct: 273  WPILKGFQEGPLNFAPTFKFDVGTNKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGRKS 332

Query: 822  EDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVA--LIDIDIFEVEAEERQ 879
              L +   S++                    E   SDH+PV A  L+     +     R 
Sbjct: 333  HRLQVTQHSYR-----------------SHMEYTVSDHKPVAAQFLLQFAFRDDMPLVRL 375

Query: 880  NIYKEVIAVQGPPDGTVLVSIKSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMW 939
             +  E +    P    V   +++    +++    L     +    +   +  +  ED   
Sbjct: 376  EVADEWVR---PEQAVVRYRMETVFARSSWDWIGLYRVGFRHCKDYVAYVWAKH-EDVDG 431

Query: 940  VTFLEGSSALNVLSLNGKELL-----NRTITIALKSPDWIKNLEEEMSLEKISIALPSST 994
             T+    S  ++   +G  +L     N +I I +  P                I+LPSS 
Sbjct: 432  NTYQVTFSEESLPKGHGDFILGYYSHNHSILIGITEP--------------FQISLPSSE 477

Query: 995  SSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSP 1054
                L   +  ++    EG+ DD + E+       L P S S    SP  S R    +SP
Sbjct: 478  ----LASSSTDSSGTSSEGE-DDSTLEL-------LAPKSRS---PSPGKSKR-HRSRSP 521

Query: 1055 TISEGPVPSLPIRPS----RAPSRTPGPPSAQSSPIDAQPAT-----PLPQKDPAQPLEP 1105
             ++    P L +RPS    R  SR+P P S + S +    ++        ++ P+    P
Sbjct: 522  GLAR--FPGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGP 579

Query: 1106 KRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKS 1147
               PP  P +    PA       P G  S  P R+   AP S
Sbjct: 580  WAFPPAVPRSLGLLPALRLETVDPGGGGSWGPDREAL-APNS 620


>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens]
          Length = 1258

 Score =  158 bits (400), Expect = 3e-38
 Identities = 204/819 (24%), Positives = 325/819 (39%), Gaps = 166/819 (20%)

Query: 510  QSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLA 569
            + A  ++L+ M     K  +P  I V +GTWN+      +++       T W        
Sbjct: 401  REAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNV-------TSWFTSK---- 449

Query: 570  GIQEFQDKRSK--PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR--DNKY 625
            G+ +  D+ +   P DI+  G +E            ++   + W   L+  +    D  Y
Sbjct: 450  GLGKTLDEVTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDY 497

Query: 626  VLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCF 685
              +A + L  + + V ++P+H   I  V+  +VKTG+    GNKGAV +  +F+ TS  F
Sbjct: 498  RPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGF 557

Query: 686  VCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHD------YVFWCGDFNYRIDLPN 739
            V  H  +G  +   RN+++++I R LS    R L + D      ++FW GD NYR+D+  
Sbjct: 558  VNCHLTSGNEKTARRNQNYLDILRLLSLG-DRQLNAFDISLRFTHLFWFGDLNYRLDMDI 616

Query: 740  EEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDD------- 792
            +E+   I ++ ++ L+  DQL  ++   +VF  F E +++F PTY+Y+  S D       
Sbjct: 617  QEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQ 676

Query: 793  YDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASF--------QDESKILYTWTPG 844
              T  +   P+W DR+LW        +S  +  ++  S+         D S +  T+  G
Sbjct: 677  KPTGVRTNVPSWCDRILW--------KSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVG 728

Query: 845  TLLHY--GRAELKTSDHRPVVALIDIDIFE--VEAEERQNIYKEVIAVQGPPDGTVLVSI 900
                +   +   KTSD     A I+ +  E  V+   R   + E  +       T L   
Sbjct: 729  VTSQFISKKGLSKTSDQ----AYIEFESIEAIVKTASRTKFFIEFYS-------TCLEEY 777

Query: 901  KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSS-ALNVLSLNGKEL 959
            K S  EN+      I+ L  Q++S     L   + D   + +L+     L V S++G E 
Sbjct: 778  KKSF-ENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYLQDQHLLLTVKSMDGYES 833

Query: 960  LNRTITIALKSP---------DWIKNLEEEMS--LEKISIALPSSTSSTLLGEDAEVAAD 1008
                + +ALKS           ++ +  EE       + + +P+    T           
Sbjct: 834  YGECV-VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGT----------- 881

Query: 1009 FDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG--PVPSLPI 1066
               E   +  S + +E   +   PS S G     S  PR S  + P  +E   P+  L  
Sbjct: 882  --RERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPR-SGSRKPAFTEASCPLSRLFE 933

Query: 1067 RPSRAP--SRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPR-----PVAPPTR 1119
             P + P   R P PP A       +P TP  + + A   E    PPP+     P      
Sbjct: 934  EPEKPPPTGRPPAPPRAAPR---EEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLE 990

Query: 1120 PAPPQ--RPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYST 1177
              P Q   P PPS AR+P P            +  K+ +  + P+PQ G           
Sbjct: 991  GVPHQLLPPEPPSPARAPVP------------SATKNKVAITVPAPQLG----------- 1027

Query: 1178 ARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQS-- 1235
                             H R   G     S  ++  T     F P PL   A F P S  
Sbjct: 1028 --------------HHRHPRVGEG---SSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLD 1070

Query: 1236 SLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRS 1274
             LP P  R +        P P++ P+P L  PP P P S
Sbjct: 1071 PLPGPVVRGRGGAEARGPPPPKAHPRPPL--PPGPSPAS 1107



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 44/162 (27%), Positives = 56/162 (34%), Gaps = 18/162 (11%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            V E +P  L P        SP+ +P  S  ++      P P L     R P    G  S 
Sbjct: 988  VLEGVPHQLLPPEPP----SPARAPVPSATKNKVAITVPAPQLGHH--RHPRVGEGSSSD 1041

Query: 1082 QSS----PIDAQPATPLPQKDPAQPLEPKRPPPPRPV------APPTRPAPPQRPPPPSG 1131
            + S    P    P  PLP  D A  L P   P P PV      A    P PP+  P P  
Sbjct: 1042 EESGGTLPPPDFPPPPLP--DSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPL 1099

Query: 1132 ARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPA 1173
               P+P     G   S        +  ++   +   A  GPA
Sbjct: 1100 PPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPA 1141


>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
          Length = 644

 Score =  135 bits (341), Expect = 2e-31
 Identities = 104/360 (28%), Positives = 159/360 (44%), Gaps = 71/360 (19%)

Query: 526 KYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIF 585
           +Y   + + + V TWN+ G K+         +L ++LL A           +     D++
Sbjct: 292 RYFPDRNVALFVATWNMQGQKELPP------SLDEFLLPA-----------EADYAQDLY 334

Query: 586 AIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISRDNKYVLLASEQLVGVCLFVFIRPQ 645
            IG +E              ++++ W   LQ+T+     YVLL+S     + + +FIR  
Sbjct: 335 VIGVQE------------GCSDRREWETRLQETLGPH--YVLLSSAAHGVLYMSLFIRRD 380

Query: 646 HAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFI 705
              F  +V   TV T +      KGA+ I   F  TS  F+ SHF +G  +V ER  D+ 
Sbjct: 381 LIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYT 440

Query: 706 EIARKLSFPMG------------RMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQ---N 750
              + L  P               +    D VFW GDFN+R+      V  L+ Q    +
Sbjct: 441 RTVQALVLPRNVPDTNPYRSSAADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVD 500

Query: 751 WDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLW 810
             +L+  DQLI +   G +F+GF E  + F P+YK+D+  D YD++ K RTP++TDRVL+
Sbjct: 501 VPALLQHDQLIREMRKGSIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLY 560

Query: 811 RRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDIDI 870
           R R                   D   + Y+  PG         +KTSDHRPV  L  + +
Sbjct: 561 RSR----------------HKGDICPVSYSSCPG---------IKTSDHRPVYGLFRVKV 595



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 52/212 (24%), Positives = 84/212 (39%), Gaps = 34/212 (16%)

Query: 1044 SSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQ-PATPLPQKDPAQP 1102
            S P   P +  T+ +G +P  P  P++     P  P ++S  +    PATP  +  PA+ 
Sbjct: 11   SEPAPQPPEGRTL-QGQLPGAP--PAQRAGSPPDAPGSESPALACSTPATPSGEDPPAR- 66

Query: 1103 LEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPS 1162
                        A P  P PP R   P   R+ +   K +   +  G +++D   R+  S
Sbjct: 67   ------------AAPIAPRPPAR---PRLERALSLDDKGWRRRRFRG-SQEDLEARNGTS 110

Query: 1163 PQAGLA---GPG-------PAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTS 1212
            P  G     GPG       P   ST+   IP   GV+S+ +    +    L+  + S  +
Sbjct: 111  PSRGSVQSEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSGGNPLSGVASSSPN 170

Query: 1213 ETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1244
               + +       +  +  PP+   PPPA  L
Sbjct: 171  LPHRDAAVAGSSPRLPSLLPPR---PPPALSL 199



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 52/201 (25%), Positives = 69/201 (34%), Gaps = 43/201 (21%)

Query: 1104 EPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSP 1163
            E  RP  P P  P  R    Q P  P   R+ +P       P +PG +    +  S P+ 
Sbjct: 6    ENLRPSEPAPQPPEGRTLQGQLPGAPPAQRAGSP-------PDAPG-SESPALACSTPAT 57

Query: 1164 QAGLAGPGPAGYSTARPTIPPR-AGVISAPQSHARASAGRLTPE--------SQSKTSET 1214
             +G   P  A     RP   PR    +S      R    R + E        S S+ S  
Sbjct: 58   PSGEDPPARAAPIAPRPPARPRLERALSLDDKGWRRRRFRGSQEDLEARNGTSPSRGSVQ 117

Query: 1215 SKG-------------STFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ---- 1257
            S+G             ST L E  K +     +   P        PL  VA+  P     
Sbjct: 118  SEGPGAPAHSCSPPCLSTSLQEIPKSRGVLSSERGSPSSG---GNPLSGVASSSPNLPHR 174

Query: 1258 ----SGPQPNLET--PPQPPP 1272
                +G  P L +  PP+PPP
Sbjct: 175  DAAVAGSSPRLPSLLPPRPPP 195


>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
           sapiens]
          Length = 448

 Score =  133 bits (335), Expect = 1e-30
 Identities = 98/301 (32%), Positives = 153/301 (50%), Gaps = 23/301 (7%)

Query: 576 DKRSKPTDIFAIGFEEMVELNAG--NIVSASTTNQKLWAVELQKTISRDNKYVLLASEQL 633
           + R+   DI+ IG +E   LN+G  +++S +  N   W+  L   +S    ++ ++  ++
Sbjct: 39  NNRNLNLDIYVIGLQE---LNSGIISLLSDAAFNDS-WSSFLMDVLS-PLSFIKVSHVRM 93

Query: 634 VGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAG 693
            G+ L VF + QH P+I+ ++  +  TG+ G  GNKG V I +  +   +  +  H    
Sbjct: 94  QGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVSIINCHLPPH 153

Query: 694 QSQVKERNEDFIEIARKLSFPMGR---MLFSHDYVFWCGDFNYRI-DLPNEEVKELIRQQ 749
            S   +R E F  I    +   GR    +  HD + W GD N+RI D     V+E I+ +
Sbjct: 154 ISNNYQRLEHFDRILEMQNCE-GRDIPNILDHDLIIWFGDMNFRIEDFGLHFVRESIKNR 212

Query: 750 NWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVL 809
            +  L   DQL   K    + R F EG++ F PTYK+D  S+DYDTSEK R PAWTDR+L
Sbjct: 213 CYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKRKPAWTDRIL 272

Query: 810 WRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHRPVVALIDID 869
           WR ++ P   +  D  +  AS    S   Y+    + + YG      SDH+PV    D++
Sbjct: 273 WRLKRQPC--AGPDTPIPPASHFSLSLRGYS----SHMTYG-----ISDHKPVSGTFDLE 321

Query: 870 I 870
           +
Sbjct: 322 L 322


>gi|7662034 Sac domain-containing inositol phosphatase 3 [Homo
           sapiens]
          Length = 907

 Score =  130 bits (326), Expect = 1e-29
 Identities = 142/521 (27%), Positives = 230/521 (44%), Gaps = 108/521 (20%)

Query: 55  KVLDAYGLLGVLRLNLGDTMLHYLVLVTGCMSVGKIQESEVFRVTSTEFI-----SLRID 109
           + + A+G++G +R   G    +Y+VL+T    +  I    +++V  T  I     S+R+ 
Sbjct: 88  RAVSAFGVVGFVRFLEG----YYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVT 143

Query: 110 SSDEDRISEV-RKVLNSGNFYFAWSAS-GISLDLSLNAHRS----MQEQTTDNR------ 157
             DE R   + + V  S NFYF++S     SL  +L   R     ++ + T NR      
Sbjct: 144 HPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDI 203

Query: 158 ------------------------FFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIY 193
                                   + WN  L   +K       DWLL ++ G      + 
Sbjct: 204 FEDEGLITQGGSGVFGICSEPYMKYVWNGELLDIIK--STVHRDWLLYIIHGFCGQSKLL 261

Query: 194 AAHKQAKACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVV-------YLDDSVSSF 246
              +     LI+R S + AGTRF  RG N +G VAN VETEQ++       +   S SS+
Sbjct: 262 IYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSY 321

Query: 247 IQIRGSVPLFWEQP-GLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIV-NLLGS 304
           +Q+RGSVPL+W Q     +    + + +  +  A     HF  +   +G  II+ NL+  
Sbjct: 322 VQVRGSVPLYWSQDISTMMPKPPITLDQA-DPFAHVAALHFDQMFQRFGSPIIILNLVKE 380

Query: 305 KEG---EHMLSK------AFQSHLKASEHAADIQMVNFDYHQMVKG---GKAEKLHSVLK 352
           +E    E +LS+       + +     EH   I  + +D  +  K       ++L+ + +
Sbjct: 381 REKRKHERILSEELVAAVTYLNQFLPPEHT--IVYIPWDMAKYTKSKLCNVLDRLNVIAE 438

Query: 353 PQVQKFLDYGFFY------------------FNGSEVQ--RCQSGTVRTNCLDCLDRTNS 392
             V+K    GFF                     G  +   R Q+G +RTNC+DCLDRTN+
Sbjct: 439 SVVKKT---GFFVNRPDSYCSILRPDEKWNELGGCVIPTGRLQTGILRTNCVDCLDRTNT 495

Query: 393 VQAFLGLEMLAKQLEALGLAEKP--QLVTRFQEVFRSMWSVNGDSISKIYAGTGALEGKA 450
            Q  +G   LA QL +LGL +KP  Q  T    +F  ++  +GD++S  Y G+  L  + 
Sbjct: 496 AQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGS-QLVHRV 554

Query: 451 KL-----------KDGARSVTRTIQNNFFDSSKQEAIDVLL 480
           K            KD  ++++R   N F D+ +Q++I++ L
Sbjct: 555 KTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFL 595


>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  125 bits (314), Expect = 3e-28
 Identities = 84/250 (33%), Positives = 128/250 (51%), Gaps = 16/250 (6%)

Query: 625 YVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLC 684
           ++ ++  ++ G+ L VF + QH P+I+ ++  +  TG+ G  GNKG V I +  +   + 
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 685 FVCSHFAAGQSQVKERNEDFIEIARKLSFPMGR---MLFSHDYVFWCGDFNYRI-DLPNE 740
            +  H     S   +R E F  I    +   GR    +  HD + W GD N+RI D    
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILEMQNCE-GRDIPNILDHDLIIWFGDMNFRIEDFGLH 127

Query: 741 EVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCR 800
            V+E I+ + +  L   DQL   K    + R F EG++ F PTYK+D  S+DYDTSEK R
Sbjct: 128 FVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKR 187

Query: 801 TPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHR 860
            PAWTDR+LWR ++ P   +  D  +  AS    S   Y+    + + YG      SDH+
Sbjct: 188 KPAWTDRILWRLKRQPC--AGPDTPIPPASHFSLSLRGYS----SHMTYG-----ISDHK 236

Query: 861 PVVALIDIDI 870
           PV    D+++
Sbjct: 237 PVSGTFDLEL 246


>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
           sapiens]
          Length = 372

 Score =  125 bits (314), Expect = 3e-28
 Identities = 84/250 (33%), Positives = 128/250 (51%), Gaps = 16/250 (6%)

Query: 625 YVLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLC 684
           ++ ++  ++ G+ L VF + QH P+I+ ++  +  TG+ G  GNKG V I +  +   + 
Sbjct: 9   FIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLYGYYVS 68

Query: 685 FVCSHFAAGQSQVKERNEDFIEIARKLSFPMGR---MLFSHDYVFWCGDFNYRI-DLPNE 740
            +  H     S   +R E F  I    +   GR    +  HD + W GD N+RI D    
Sbjct: 69  IINCHLPPHISNNYQRLEHFDRILEMQNCE-GRDIPNILDHDLIIWFGDMNFRIEDFGLH 127

Query: 741 EVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCR 800
            V+E I+ + +  L   DQL   K    + R F EG++ F PTYK+D  S+DYDTSEK R
Sbjct: 128 FVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSNDYDTSEKKR 187

Query: 801 TPAWTDRVLWRRRKWPFDRSAEDLDLLNASFQDESKILYTWTPGTLLHYGRAELKTSDHR 860
            PAWTDR+LWR ++ P   +  D  +  AS    S   Y+    + + YG      SDH+
Sbjct: 188 KPAWTDRILWRLKRQPC--AGPDTPIPPASHFSLSLRGYS----SHMTYG-----ISDHK 236

Query: 861 PVVALIDIDI 870
           PV    D+++
Sbjct: 237 PVSGTFDLEL 246


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 97.4 bits (241), Expect = 8e-20
 Identities = 85/287 (29%), Positives = 108/287 (37%), Gaps = 33/287 (11%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPP-----SAQS 1083
            P      G  P      SP   P   +GP P   + P  P   P +  GPP       Q 
Sbjct: 93   PPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG 152

Query: 1084 SPIDAQPATPLPQKDP------AQPLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGARS 1134
             P   +P  P PQ D       + P +P+ PPP    +P  PP  P  PQ PPP  G + 
Sbjct: 153  PPPPGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKP 212

Query: 1135 PAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYS--------TARPTIPPRA 1186
              P     G P+ P   + DN  +S  SP     GP P G +          +P  PP  
Sbjct: 213  QGPPPP--GKPQGP-PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ 269

Query: 1187 GVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQE 1246
            G  + PQ        +  P      S +S+     P+   PQ    PQ   PPP +    
Sbjct: 270  GG-NKPQGPPPPGKPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGP 328

Query: 1247 PLVPVAAPMPQSGPQPNLE--TPPQPPPRSRSSHSLPSEASSQPQQE 1291
            P  P     PQ  P P      PPQ   +SRS+ S P +    PQQE
Sbjct: 329  P--PQGGNKPQGPPPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQE 373



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 84/275 (30%), Positives = 109/275 (39%), Gaps = 29/275 (10%)

Query: 1041 SPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPA 1100
            SP   P+  P Q     +GP P  P +P   P +    P  Q  P   +P  P PQ D +
Sbjct: 52   SPPGKPQGPPPQGGNQPQGPPPP-PGKPQGPPPQGGNKP--QGPPPPGKPQGPPPQGDKS 108

Query: 1101 Q-----PLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTR 1152
            +     P +P+ PPP    +P  PP  P  PQ PPP  G +   P     G P+ P   +
Sbjct: 109  RSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPP--GKPQGP-PPQ 165

Query: 1153 KDNIGRSQPSPQAGLAGPGPAGYS--------TARPTIPPRAGVISAPQSHARASAGRLT 1204
             DN  RS  SP     GP P G +          +P  PP  G  + PQ        +  
Sbjct: 166  GDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG-NKPQGPPPPGKPQGP 224

Query: 1205 PESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNL 1264
            P      S++++     P+   PQ    PQ   PPP +    P  P     PQ  P P  
Sbjct: 225  PPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP--PQGGNKPQGPPPPGK 282

Query: 1265 E--TPPQPPPRSRSSHSLPSEASSQPQQ--EQPSG 1295
                PPQ   +SRSS S P +    P Q   QP G
Sbjct: 283  PQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQG 317



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 76/267 (28%), Positives = 103/267 (38%), Gaps = 33/267 (12%)

Query: 1038 LGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            L ++ + +   S  +SP++  G     P +    P   P PP     P         PQ 
Sbjct: 13   LSSAQNLNEDVSQEESPSLIAGNPQGAPPQGGNKPQGPPSPPGKPQGP--PPQGGNQPQG 70

Query: 1098 DPAQPLEPKRPPPP---RPVAPPTRPAPPQRP--PPPSGARSPAPTRKEFGAPKSPGTTR 1152
             P  P +P+ PPP    +P  PP    PP +P  PPP G +S +P R   G P+ P   +
Sbjct: 71   PPPPPGKPQGPPPQGGNKPQGPP----PPGKPQGPPPQGDKSRSP-RSPPGKPQGP-PPQ 124

Query: 1153 KDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTS 1212
              N  +  P P     GP P G +  +P  PP  G    P            P      S
Sbjct: 125  GGNQPQGPPPPPGKPQGPPPQGGN--KPQGPPPPGKPQGP------------PPQGDNKS 170

Query: 1213 ETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE--TPPQP 1270
             +S+     P+   PQ    PQ   PPP +    P  P     PQ  P P      PPQ 
Sbjct: 171  RSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP--PQGGNKPQGPPPPGKPQGPPPQG 228

Query: 1271 PPRSRSSHSLPSEASSQPQQ--EQPSG 1295
              +S+S+ S P +    P Q   QP G
Sbjct: 229  DNKSQSARSPPGKPQGPPPQGGNQPQG 255



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 74/258 (28%), Positives = 99/258 (38%), Gaps = 21/258 (8%)

Query: 1031 QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            Q  + S    SP   P+  P Q     +GP P  P +P   P +    P  Q  P   +P
Sbjct: 165  QGDNKSRSSRSPPGKPQGPPPQGGNQPQGPPPP-PGKPQGPPPQGGNKP--QGPPPPGKP 221

Query: 1091 ATPLPQKDP------AQPLEPKRPPPP---RPVAPPTRPAPPQRPPPPSG--ARSPAPTR 1139
              P PQ D       + P +P+ PPP    +P  PP  P  PQ PPP  G   + P P  
Sbjct: 222  QGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPG 281

Query: 1140 KEFGAPKSPGTTRKDN---IGRSQ-PSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSH 1195
            K  G P   G+  + +    G+ Q P PQ G    GP          PP+ G  + PQ  
Sbjct: 282  KPQGPPPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG--NKPQGP 339

Query: 1196 ARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPM 1255
                  +  P      S +++     P+    Q    PQ   PP     Q+P  P A   
Sbjct: 340  PPPGKPQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAPPAG-Q 398

Query: 1256 PQSGPQPNLETPPQPPPR 1273
            PQ  P+P     P  PP+
Sbjct: 399  PQGPPRPPQGGRPSRPPQ 416


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 66/239 (27%), Positives = 95/239 (39%), Gaps = 18/239 (7%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+  S+P T    +PT ++ P P+ P  P+   ++ P P + +S+P   +   P   K P
Sbjct: 250  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 309

Query: 1100 AQPLEPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            A P  PK P P  P  P    P  PAP  + P P+  + PAPT     APK P  T    
Sbjct: 310  A-PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-----APKKPAPTTP-- 361

Query: 1156 IGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTPESQSKTSE 1213
                +P+P      P P       PT P  P      +  +  +  A   T  + +   E
Sbjct: 362  ---KEPAPTTP-KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417

Query: 1214 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
             S  +T  P P  P+   P     P P    +        P P +  +P   TP +P P
Sbjct: 418  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 476



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 69/279 (24%), Positives = 104/279 (37%), Gaps = 40/279 (14%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            P+++    T+P     T+P + +PT  + P P+ P  P+    + P P + + +P   + 
Sbjct: 288  PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE 347

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAP------------PTRPAPPQRPPPPSGARSPAPT 1138
              P   K PA P  PK P P  P  P            P  PAP      P+  + PAPT
Sbjct: 348  PAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 406

Query: 1139 RKEFG------------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARP 1180
              +                     PK P  T       + P   A      PA  +T +P
Sbjct: 407  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 466

Query: 1181 T-IPPRAGVISAPQSHARASAGRLTPESQSKTSETS--KGSTFLPEPLKPQAAFPPQSSL 1237
                P+    + P+  A  +  +LTP +  K + T+  K +   PE L P     P  + 
Sbjct: 467  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 526

Query: 1238 P----PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
            P    P   +   P  P   P P +  +P   TP +P P
Sbjct: 527  PEEPAPTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPAP 564



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 32/266 (12%)

Query: 1040 TSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKD 1098
            T+P     T+P + +PT  + P P+    PS    + P P + +S+P   +   P   K 
Sbjct: 351  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 410

Query: 1099 -PAQPLEP-----KRPPPPRPVAP----PTRPAP-PQRPPPPSGARSPAPTRKEFGAPKS 1147
             P  P EP     K P P  P  P    P +PAP   + P P+  + PAPT  +  AP +
Sbjct: 411  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 470

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
            P           +P+P        P       PT P +    + P+  A  +   L P +
Sbjct: 471  P----------KEPAPTTP-KETAPTTPKKLTPTTPEKLAP-TTPEKPAPTTPEELAPTT 518

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP 1267
              + + T+      P P  P+AA P     P P      P  P      +  P    ET 
Sbjct: 519  PEEPTPTTPEE---PAPTTPKAAAPNTPKEPAPT----TPKEPAPTTPKEPAPTTPKETA 571

Query: 1268 PQPPPRSRSSHSLPSEASSQPQQEQP 1293
            P   P+  +  +L   A + P++  P
Sbjct: 572  P-TTPKGTAPTTLKEPAPTTPKKPAP 596



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 35/252 (13%)

Query: 1028 QHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPID 1087
            Q ++ +S+  L  +     + +P ++ T ++GP  + P  P+         P+    P  
Sbjct: 177  QSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT---------PTTPKEPAS 226

Query: 1088 AQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKS 1147
              P  P P    + P  PK P P    + PT P    + P P+  + PAPT      PK 
Sbjct: 227  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP----KEPAPTTTKEPAPT-----TPKE 277

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTP 1205
            P  T        +P+P    + P     +T +   P  P+    + P+  A  +    TP
Sbjct: 278  PAPTTT-----KEPAPTTTKSAP-----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 327

Query: 1206 ESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1265
             +  + + T+K     P P  P+   P     P P    +        P P +  +P+  
Sbjct: 328  TTPKEPAPTTKE----PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 383

Query: 1266 TPPQPPPRSRSS 1277
            TP +P P +  S
Sbjct: 384  TPKEPAPTTTKS 395



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 70/280 (25%), Positives = 108/280 (38%), Gaps = 35/280 (12%)

Query: 1031 QPSSSSGLGTSPSSSPRTSPCQ----SPTISEGPVPSLP--IRPSRAPSRTPGPPSAQSS 1084
            +P+ ++   T+P++  + +P      +PT  E P P+ P  + P+     TP  P  + +
Sbjct: 473  EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE-EPA 531

Query: 1085 PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPP----PSGARSPAPTR 1139
            P   + A P   K+PA P  PK P P  P  P PT P       P    P+  + PAPT 
Sbjct: 532  PTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTT 590

Query: 1140 KEFGAPK--SPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1197
             +  APK  +P TT++               G  P       PT P      + P+  A 
Sbjct: 591  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP-TTPKGTAP 649

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL---PPPAQRLQEPLVPVAAP 1254
             +     P +  K +         P+ L P     P S+    P P    +        P
Sbjct: 650  TTLKEPAPTTPKKPA---------PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 700

Query: 1255 MPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
             P +  +P   TP  PPP +       SE S+    ++P+
Sbjct: 701  APTTPKKPAPTTPETPPPTT-------SEVSTPTTTKEPT 733



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 66/264 (25%), Positives = 100/264 (37%), Gaps = 23/264 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIR-----PSRAPSRTPGPPSAQSSPIDAQPATPL 1094
            T+   +P T    +PT  +   P+ P +     P +    TP  P A ++P +  P TP 
Sbjct: 462  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP-APTTPEELAPTTP- 519

Query: 1095 PQKDPAQPLEPKRPPPPRPVAP--PTRPAPPQ-RPPPPSGARSPAPTRKEFGAPKSPGTT 1151
             +  P  P EP  P  P+  AP  P  PAP   + P P+  + PAPT  +  AP +P  T
Sbjct: 520  EEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 578

Query: 1152 RKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKT 1211
                +    P+     A    A  +T  PT    +     P           TP+  + T
Sbjct: 579  APTTLKEPAPTTPKKPAPKELAPTTTKEPT----STTCDKPAPTTPKGTAPTTPKEPAPT 634

Query: 1212 SETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
            +         P P  P+   P     P P    ++P     AP    GP       P P 
Sbjct: 635  TPKE------PAPTTPKGTAPTTLKEPAPTTP-KKPAPKELAPTTTKGPTSTTSDKPAPT 687

Query: 1272 PRSRSSHSLPSE-ASSQPQQEQPS 1294
                ++ + P E A + P++  P+
Sbjct: 688  TPKETAPTTPKEPAPTTPKKPAPT 711



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 67/279 (24%), Positives = 99/279 (35%), Gaps = 26/279 (9%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            +E+   + L P+S      +P +   T      T  E P P+ P  P+    + P P + 
Sbjct: 179  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTI 237

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPPPSGARSPAPTRK 1140
            +S+P    P  P P    + P  PK P P     P PT P    + P P+  + PAPT  
Sbjct: 238  KSAP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP----KEPAPTTTKEPAPTTT 291

Query: 1141 EFG--APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA 1198
            +     PK P  T       + P        P P       PT P       AP +   A
Sbjct: 292  KSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKEP----APTTKEPA 341

Query: 1199 SAGRLTPESQSKTSETSKGSTFL--PEPLKPQAAFPPQSSLPPPAQRLQE-PLVPVAAPM 1255
                 TP+  + T+      T    P P  P+   P  +  P P    +  P    +AP 
Sbjct: 342  PT---TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 398

Query: 1256 PQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                P P         P+  S  +    A + P++  P+
Sbjct: 399  TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 437



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 62/280 (22%), Positives = 103/280 (36%), Gaps = 22/280 (7%)

Query: 1026 LPQHLQPSSSSGLGTSPSSS---PRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQ 1082
            LP +   S  + L  +  ++     T+     T ++G   +   + +++  +T     A 
Sbjct: 130  LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 189

Query: 1083 SSPIDAQPATPLPQKDPAQPL--EPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPA 1136
            +S + A+P TP  +     P    PK P P  P  P    P  P P      P+  + PA
Sbjct: 190  TSKVLAKP-TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 248

Query: 1137 PTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHA 1196
            PT       KS  TT K+    +   P A      PA  +T  P         + P+  A
Sbjct: 249  PT-----TTKSAPTTPKEPAPTTTKEP-APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 302

Query: 1197 RASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMP 1256
              +  +  P +  + + T+      P P  P+   P      P   +   P  P   P P
Sbjct: 303  PTTPKKPAPTTPKEPAPTTPKE---PTPTTPKEPAPTTKEPAPTTPKEPAPTAP-KKPAP 358

Query: 1257 QSGPQPNLETPPQPPPRS--RSSHSLPSEASSQPQQEQPS 1294
             +  +P   TP +P P +    S + P E +    +  P+
Sbjct: 359  TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 398



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 62/240 (25%), Positives = 89/240 (37%), Gaps = 69/240 (28%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSR---APSRTPGPPS------AQSSPIDAQP 1090
            T   ++P T    +PT  + P P+ P +P+    AP+ T  P S      A ++P    P
Sbjct: 566  TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 625

Query: 1091 ATPLPQKDPAQPLEPKRPPP--PRPVAPPT--RPAP--PQRPPP---------------- 1128
             TP   K+PA P  PK P P  P+  AP T   PAP  P++P P                
Sbjct: 626  TTP---KEPA-PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 681

Query: 1129 ------------PSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYS 1176
                        P+  + PAPT  +  AP +P T        S P+             +
Sbjct: 682  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT-------------T 728

Query: 1177 TARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236
            T  PT   ++   S P+         L+ E   K  E S     +P    P A  P  ++
Sbjct: 729  TKEPTTIHKSPDESTPE---------LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 779



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 51/254 (20%), Positives = 93/254 (36%), Gaps = 21/254 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGP--VPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            T  +  P TS   +PT ++ P  +   P   +   S  P P + ++SP   +P  P  + 
Sbjct: 712  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP--KEPGVPTTKT 769

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
              A   E       +      R  P      P   +  A T ++    K   TT +    
Sbjct: 770  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 829

Query: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG 1217
             +Q +         P   +T + T    A  ++  +     +     PE  +K  + +  
Sbjct: 830  TTQDTT--------PFKITTLKTT--TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN 879

Query: 1218 S-TFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRS 1276
            S    P+P KP  A  P+    P + +  + +  V  P     P+    T P+  P SR 
Sbjct: 880  SKATTPKPQKPTKA--PKK---PTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRI 934

Query: 1277 SHSLPSEASSQPQQ 1290
            + ++  + +++P Q
Sbjct: 935  AEAM-LQTTTRPNQ 947



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 37/189 (19%), Positives = 67/189 (35%), Gaps = 6/189 (3%)

Query: 1110 PPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAG 1169
            P    A P  P P   PP    ++  + T  +    ++  TT  +    +    +   A 
Sbjct: 116  PKITTAKPINPRP-SLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAK 174

Query: 1170 PGPAGYSTARPTIPPRAGVISAPQSHARASA---GRLTPESQSKTSETSKGSTFLPEPLK 1226
               +   T+   + P + V++ P   A  +       TP+  + T+     ST   EP  
Sbjct: 175  ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTP 234

Query: 1227 PQAAFPPQSSLPP-PAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEAS 1285
                  P +   P P      P  P   P P +  +P   TP +P P +    +  +  S
Sbjct: 235  TTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 293

Query: 1286 SQPQQEQPS 1294
            +    ++P+
Sbjct: 294  APTTPKEPA 302



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 30/251 (11%)

Query: 969  KSPDWIKNLEEEMSLEKISIALPSS----------TSSTLLGEDAEVAADFDMEGDVDDY 1018
            KSPD       E+S E    AL +S          T +    E    A D   E D+   
Sbjct: 737  KSPD---ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT- 792

Query: 1019 SAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRT 1075
            + E     P+  + ++++   T+ S    T+   + T ++   P   +     + AP  T
Sbjct: 793  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 852

Query: 1076 PGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135
                +  ++ I  +P      KD A   +   P P +P   P +P   ++P         
Sbjct: 853  TTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP--------- 903

Query: 1136 APTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISA-PQS 1194
              T      PK+  T RK      + +P + +A       +T RP   P + ++   P+S
Sbjct: 904  -KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIA--EAMLQTTTRPNQTPNSKLVEVNPKS 960

Query: 1195 HARASAGRLTP 1205
                 A   TP
Sbjct: 961  EDAGGAEGETP 971


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 66/239 (27%), Positives = 95/239 (39%), Gaps = 18/239 (7%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+  S+P T    +PT ++ P P+ P  P+   ++ P P + +S+P   +   P   K P
Sbjct: 291  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 350

Query: 1100 AQPLEPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            A P  PK P P  P  P    P  PAP  + P P+  + PAPT     APK P  T    
Sbjct: 351  A-PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-----APKKPAPTTP-- 402

Query: 1156 IGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTPESQSKTSE 1213
                +P+P      P P       PT P  P      +  +  +  A   T  + +   E
Sbjct: 403  ---KEPAPTTP-KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458

Query: 1214 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
             S  +T  P P  P+   P     P P    +        P P +  +P   TP +P P
Sbjct: 459  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 517



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 69/279 (24%), Positives = 104/279 (37%), Gaps = 40/279 (14%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            P+++    T+P     T+P + +PT  + P P+ P  P+    + P P + + +P   + 
Sbjct: 329  PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE 388

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAP------------PTRPAPPQRPPPPSGARSPAPT 1138
              P   K PA P  PK P P  P  P            P  PAP      P+  + PAPT
Sbjct: 389  PAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 447

Query: 1139 RKEFG------------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARP 1180
              +                     PK P  T       + P   A      PA  +T +P
Sbjct: 448  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 507

Query: 1181 T-IPPRAGVISAPQSHARASAGRLTPESQSKTSETS--KGSTFLPEPLKPQAAFPPQSSL 1237
                P+    + P+  A  +  +LTP +  K + T+  K +   PE L P     P  + 
Sbjct: 508  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 567

Query: 1238 P----PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
            P    P   +   P  P   P P +  +P   TP +P P
Sbjct: 568  PEEPAPTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPAP 605



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 32/266 (12%)

Query: 1040 TSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKD 1098
            T+P     T+P + +PT  + P P+    PS    + P P + +S+P   +   P   K 
Sbjct: 392  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 451

Query: 1099 -PAQPLEP-----KRPPPPRPVAP----PTRPAP-PQRPPPPSGARSPAPTRKEFGAPKS 1147
             P  P EP     K P P  P  P    P +PAP   + P P+  + PAPT  +  AP +
Sbjct: 452  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 511

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
            P           +P+P        P       PT P +    + P+  A  +   L P +
Sbjct: 512  P----------KEPAPTTP-KETAPTTPKKLTPTTPEKLAP-TTPEKPAPTTPEELAPTT 559

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP 1267
              + + T+      P P  P+AA P     P P      P  P      +  P    ET 
Sbjct: 560  PEEPTPTTPEE---PAPTTPKAAAPNTPKEPAPT----TPKEPAPTTPKEPAPTTPKETA 612

Query: 1268 PQPPPRSRSSHSLPSEASSQPQQEQP 1293
            P   P+  +  +L   A + P++  P
Sbjct: 613  P-TTPKGTAPTTLKEPAPTTPKKPAP 637



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 35/252 (13%)

Query: 1028 QHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPID 1087
            Q ++ +S+  L  +     + +P ++ T ++GP  + P  P+         P+    P  
Sbjct: 218  QSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT---------PTTPKEPAS 267

Query: 1088 AQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKS 1147
              P  P P    + P  PK P P    + PT P    + P P+  + PAPT      PK 
Sbjct: 268  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP----KEPAPTTTKEPAPT-----TPKE 318

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTP 1205
            P  T        +P+P    + P     +T +   P  P+    + P+  A  +    TP
Sbjct: 319  PAPTTT-----KEPAPTTTKSAP-----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 368

Query: 1206 ESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1265
             +  + + T+K     P P  P+   P     P P    +        P P +  +P+  
Sbjct: 369  TTPKEPAPTTKE----PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 424

Query: 1266 TPPQPPPRSRSS 1277
            TP +P P +  S
Sbjct: 425  TPKEPAPTTTKS 436



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 70/280 (25%), Positives = 108/280 (38%), Gaps = 35/280 (12%)

Query: 1031 QPSSSSGLGTSPSSSPRTSPCQ----SPTISEGPVPSLP--IRPSRAPSRTPGPPSAQSS 1084
            +P+ ++   T+P++  + +P      +PT  E P P+ P  + P+     TP  P  + +
Sbjct: 514  EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE-EPA 572

Query: 1085 PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPP----PSGARSPAPTR 1139
            P   + A P   K+PA P  PK P P  P  P PT P       P    P+  + PAPT 
Sbjct: 573  PTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTT 631

Query: 1140 KEFGAPK--SPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1197
             +  APK  +P TT++               G  P       PT P      + P+  A 
Sbjct: 632  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP-TTPKGTAP 690

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL---PPPAQRLQEPLVPVAAP 1254
             +     P +  K +         P+ L P     P S+    P P    +        P
Sbjct: 691  TTLKEPAPTTPKKPA---------PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 741

Query: 1255 MPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
             P +  +P   TP  PPP +       SE S+    ++P+
Sbjct: 742  APTTPKKPAPTTPETPPPTT-------SEVSTPTTTKEPT 774



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 66/264 (25%), Positives = 100/264 (37%), Gaps = 23/264 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIR-----PSRAPSRTPGPPSAQSSPIDAQPATPL 1094
            T+   +P T    +PT  +   P+ P +     P +    TP  P A ++P +  P TP 
Sbjct: 503  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP-APTTPEELAPTTP- 560

Query: 1095 PQKDPAQPLEPKRPPPPRPVAP--PTRPAPPQ-RPPPPSGARSPAPTRKEFGAPKSPGTT 1151
             +  P  P EP  P  P+  AP  P  PAP   + P P+  + PAPT  +  AP +P  T
Sbjct: 561  EEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 619

Query: 1152 RKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKT 1211
                +    P+     A    A  +T  PT    +     P           TP+  + T
Sbjct: 620  APTTLKEPAPTTPKKPAPKELAPTTTKEPT----STTCDKPAPTTPKGTAPTTPKEPAPT 675

Query: 1212 SETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
            +         P P  P+   P     P P    ++P     AP    GP       P P 
Sbjct: 676  TPKE------PAPTTPKGTAPTTLKEPAPTTP-KKPAPKELAPTTTKGPTSTTSDKPAPT 728

Query: 1272 PRSRSSHSLPSE-ASSQPQQEQPS 1294
                ++ + P E A + P++  P+
Sbjct: 729  TPKETAPTTPKEPAPTTPKKPAPT 752



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 67/279 (24%), Positives = 99/279 (35%), Gaps = 26/279 (9%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            +E+   + L P+S      +P +   T      T  E P P+ P  P+    + P P + 
Sbjct: 220  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTI 278

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPPPSGARSPAPTRK 1140
            +S+P    P  P P    + P  PK P P     P PT P    + P P+  + PAPT  
Sbjct: 279  KSAP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP----KEPAPTTTKEPAPTTT 332

Query: 1141 EFG--APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA 1198
            +     PK P  T       + P        P P       PT P       AP +   A
Sbjct: 333  KSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKEP----APTTKEPA 382

Query: 1199 SAGRLTPESQSKTSETSKGSTFL--PEPLKPQAAFPPQSSLPPPAQRLQE-PLVPVAAPM 1255
                 TP+  + T+      T    P P  P+   P  +  P P    +  P    +AP 
Sbjct: 383  PT---TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 439

Query: 1256 PQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                P P         P+  S  +    A + P++  P+
Sbjct: 440  TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 478



 Score = 57.0 bits (136), Expect = 1e-07
 Identities = 62/280 (22%), Positives = 103/280 (36%), Gaps = 22/280 (7%)

Query: 1026 LPQHLQPSSSSGLGTSPSSS---PRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQ 1082
            LP +   S  + L  +  ++     T+     T ++G   +   + +++  +T     A 
Sbjct: 171  LPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAP 230

Query: 1083 SSPIDAQPATPLPQKDPAQPL--EPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPA 1136
            +S + A+P TP  +     P    PK P P  P  P    P  P P      P+  + PA
Sbjct: 231  TSKVLAKP-TPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPA 289

Query: 1137 PTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHA 1196
            PT       KS  TT K+    +   P A      PA  +T  P         + P+  A
Sbjct: 290  PT-----TTKSAPTTPKEPAPTTTKEP-APTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 343

Query: 1197 RASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMP 1256
              +  +  P +  + + T+      P P  P+   P      P   +   P  P   P P
Sbjct: 344  PTTPKKPAPTTPKEPAPTTPKE---PTPTTPKEPAPTTKEPAPTTPKEPAPTAP-KKPAP 399

Query: 1257 QSGPQPNLETPPQPPPRS--RSSHSLPSEASSQPQQEQPS 1294
             +  +P   TP +P P +    S + P E +    +  P+
Sbjct: 400  TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 439



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 62/240 (25%), Positives = 89/240 (37%), Gaps = 69/240 (28%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSR---APSRTPGPPS------AQSSPIDAQP 1090
            T   ++P T    +PT  + P P+ P +P+    AP+ T  P S      A ++P    P
Sbjct: 607  TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 666

Query: 1091 ATPLPQKDPAQPLEPKRPPP--PRPVAPPT--RPAP--PQRPPP---------------- 1128
             TP   K+PA P  PK P P  P+  AP T   PAP  P++P P                
Sbjct: 667  TTP---KEPA-PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 722

Query: 1129 ------------PSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYS 1176
                        P+  + PAPT  +  AP +P T        S P+             +
Sbjct: 723  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT-------------T 769

Query: 1177 TARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236
            T  PT   ++   S P+         L+ E   K  E S     +P    P A  P  ++
Sbjct: 770  TKEPTTIHKSPDESTPE---------LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 820



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 51/254 (20%), Positives = 93/254 (36%), Gaps = 21/254 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGP--VPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            T  +  P TS   +PT ++ P  +   P   +   S  P P + ++SP   +P  P  + 
Sbjct: 753  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP--KEPGVPTTKT 810

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
              A   E       +      R  P      P   +  A T ++    K   TT +    
Sbjct: 811  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 870

Query: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG 1217
             +Q +         P   +T + T    A  ++  +     +     PE  +K  + +  
Sbjct: 871  TTQDTT--------PFKITTLKTT--TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN 920

Query: 1218 S-TFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRS 1276
            S    P+P KP  A  P+    P + +  + +  V  P     P+    T P+  P SR 
Sbjct: 921  SKATTPKPQKPTKA--PKK---PTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRI 975

Query: 1277 SHSLPSEASSQPQQ 1290
            + ++  + +++P Q
Sbjct: 976  AEAM-LQTTTRPNQ 988



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 37/189 (19%), Positives = 67/189 (35%), Gaps = 6/189 (3%)

Query: 1110 PPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAG 1169
            P    A P  P P   PP    ++  + T  +    ++  TT  +    +    +   A 
Sbjct: 157  PKITTAKPINPRP-SLPPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAK 215

Query: 1170 PGPAGYSTARPTIPPRAGVISAPQSHARASA---GRLTPESQSKTSETSKGSTFLPEPLK 1226
               +   T+   + P + V++ P   A  +       TP+  + T+     ST   EP  
Sbjct: 216  ETQSIEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTP 275

Query: 1227 PQAAFPPQSSLPP-PAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEAS 1285
                  P +   P P      P  P   P P +  +P   TP +P P +    +  +  S
Sbjct: 276  TTIKSAPTTPKEPAPTTTKSAPTTP-KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKS 334

Query: 1286 SQPQQEQPS 1294
            +    ++P+
Sbjct: 335  APTTPKEPA 343



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 30/251 (11%)

Query: 969  KSPDWIKNLEEEMSLEKISIALPSS----------TSSTLLGEDAEVAADFDMEGDVDDY 1018
            KSPD       E+S E    AL +S          T +    E    A D   E D+   
Sbjct: 778  KSPD---ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT- 833

Query: 1019 SAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRT 1075
            + E     P+  + ++++   T+ S    T+   + T ++   P   +     + AP  T
Sbjct: 834  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 893

Query: 1076 PGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135
                +  ++ I  +P      KD A   +   P P +P   P +P   ++P         
Sbjct: 894  TTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP--------- 944

Query: 1136 APTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISA-PQS 1194
              T      PK+  T RK      + +P + +A       +T RP   P + ++   P+S
Sbjct: 945  -KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIA--EAMLQTTTRPNQTPNSKLVEVNPKS 1001

Query: 1195 HARASAGRLTP 1205
                 A   TP
Sbjct: 1002 EDAGGAEGETP 1012


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 66/239 (27%), Positives = 95/239 (39%), Gaps = 18/239 (7%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+  S+P T    +PT ++ P P+ P  P+   ++ P P + +S+P   +   P   K P
Sbjct: 343  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 402

Query: 1100 AQPLEPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            A P  PK P P  P  P    P  PAP  + P P+  + PAPT     APK P  T    
Sbjct: 403  A-PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-----APKKPAPTTP-- 454

Query: 1156 IGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTPESQSKTSE 1213
                +P+P      P P       PT P  P      +  +  +  A   T  + +   E
Sbjct: 455  ---KEPAPTTP-KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 510

Query: 1214 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
             S  +T  P P  P+   P     P P    +        P P +  +P   TP +P P
Sbjct: 511  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 569



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 69/279 (24%), Positives = 104/279 (37%), Gaps = 40/279 (14%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            P+++    T+P     T+P + +PT  + P P+ P  P+    + P P + + +P   + 
Sbjct: 381  PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE 440

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAP------------PTRPAPPQRPPPPSGARSPAPT 1138
              P   K PA P  PK P P  P  P            P  PAP      P+  + PAPT
Sbjct: 441  PAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 499

Query: 1139 RKEFG------------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARP 1180
              +                     PK P  T       + P   A      PA  +T +P
Sbjct: 500  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 559

Query: 1181 T-IPPRAGVISAPQSHARASAGRLTPESQSKTSETS--KGSTFLPEPLKPQAAFPPQSSL 1237
                P+    + P+  A  +  +LTP +  K + T+  K +   PE L P     P  + 
Sbjct: 560  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 619

Query: 1238 P----PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
            P    P   +   P  P   P P +  +P   TP +P P
Sbjct: 620  PEEPAPTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPAP 657



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 32/266 (12%)

Query: 1040 TSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKD 1098
            T+P     T+P + +PT  + P P+    PS    + P P + +S+P   +   P   K 
Sbjct: 444  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 503

Query: 1099 -PAQPLEP-----KRPPPPRPVAP----PTRPAP-PQRPPPPSGARSPAPTRKEFGAPKS 1147
             P  P EP     K P P  P  P    P +PAP   + P P+  + PAPT  +  AP +
Sbjct: 504  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 563

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
            P           +P+P        P       PT P +    + P+  A  +   L P +
Sbjct: 564  P----------KEPAPTTP-KETAPTTPKKLTPTTPEKLAP-TTPEKPAPTTPEELAPTT 611

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP 1267
              + + T+      P P  P+AA P     P P      P  P      +  P    ET 
Sbjct: 612  PEEPTPTTPEE---PAPTTPKAAAPNTPKEPAPT----TPKEPAPTTPKEPAPTTPKETA 664

Query: 1268 PQPPPRSRSSHSLPSEASSQPQQEQP 1293
            P   P+  +  +L   A + P++  P
Sbjct: 665  P-TTPKGTAPTTLKEPAPTTPKKPAP 689



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 35/252 (13%)

Query: 1028 QHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPID 1087
            Q ++ +S+  L  +     + +P ++ T ++GP  + P  P+         P+    P  
Sbjct: 270  QSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT---------PTTPKEPAS 319

Query: 1088 AQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKS 1147
              P  P P    + P  PK P P    + PT P    + P P+  + PAPT      PK 
Sbjct: 320  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP----KEPAPTTTKEPAPT-----TPKE 370

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTP 1205
            P  T        +P+P    + P     +T +   P  P+    + P+  A  +    TP
Sbjct: 371  PAPTTT-----KEPAPTTTKSAP-----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 420

Query: 1206 ESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1265
             +  + + T+K     P P  P+   P     P P    +        P P +  +P+  
Sbjct: 421  TTPKEPAPTTKE----PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 476

Query: 1266 TPPQPPPRSRSS 1277
            TP +P P +  S
Sbjct: 477  TPKEPAPTTTKS 488



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 70/280 (25%), Positives = 108/280 (38%), Gaps = 35/280 (12%)

Query: 1031 QPSSSSGLGTSPSSSPRTSPCQ----SPTISEGPVPSLP--IRPSRAPSRTPGPPSAQSS 1084
            +P+ ++   T+P++  + +P      +PT  E P P+ P  + P+     TP  P  + +
Sbjct: 566  EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE-EPA 624

Query: 1085 PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPP----PSGARSPAPTR 1139
            P   + A P   K+PA P  PK P P  P  P PT P       P    P+  + PAPT 
Sbjct: 625  PTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTT 683

Query: 1140 KEFGAPK--SPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1197
             +  APK  +P TT++               G  P       PT P      + P+  A 
Sbjct: 684  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP-TTPKGTAP 742

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL---PPPAQRLQEPLVPVAAP 1254
             +     P +  K +         P+ L P     P S+    P P    +        P
Sbjct: 743  TTLKEPAPTTPKKPA---------PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 793

Query: 1255 MPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
             P +  +P   TP  PPP +       SE S+    ++P+
Sbjct: 794  APTTPKKPAPTTPETPPPTT-------SEVSTPTTTKEPT 826



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 66/264 (25%), Positives = 100/264 (37%), Gaps = 23/264 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIR-----PSRAPSRTPGPPSAQSSPIDAQPATPL 1094
            T+   +P T    +PT  +   P+ P +     P +    TP  P A ++P +  P TP 
Sbjct: 555  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP-APTTPEELAPTTP- 612

Query: 1095 PQKDPAQPLEPKRPPPPRPVAP--PTRPAPPQ-RPPPPSGARSPAPTRKEFGAPKSPGTT 1151
             +  P  P EP  P  P+  AP  P  PAP   + P P+  + PAPT  +  AP +P  T
Sbjct: 613  EEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 671

Query: 1152 RKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKT 1211
                +    P+     A    A  +T  PT    +     P           TP+  + T
Sbjct: 672  APTTLKEPAPTTPKKPAPKELAPTTTKEPT----STTCDKPAPTTPKGTAPTTPKEPAPT 727

Query: 1212 SETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
            +         P P  P+   P     P P    ++P     AP    GP       P P 
Sbjct: 728  TPKE------PAPTTPKGTAPTTLKEPAPTTP-KKPAPKELAPTTTKGPTSTTSDKPAPT 780

Query: 1272 PRSRSSHSLPSE-ASSQPQQEQPS 1294
                ++ + P E A + P++  P+
Sbjct: 781  TPKETAPTTPKEPAPTTPKKPAPT 804



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 67/279 (24%), Positives = 99/279 (35%), Gaps = 26/279 (9%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            +E+   + L P+S      +P +   T      T  E P P+ P  P+    + P P + 
Sbjct: 272  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTI 330

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPPPSGARSPAPTRK 1140
            +S+P    P  P P    + P  PK P P     P PT P    + P P+  + PAPT  
Sbjct: 331  KSAP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP----KEPAPTTTKEPAPTTT 384

Query: 1141 EFG--APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA 1198
            +     PK P  T       + P        P P       PT P       AP +   A
Sbjct: 385  KSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKEP----APTTKEPA 434

Query: 1199 SAGRLTPESQSKTSETSKGSTFL--PEPLKPQAAFPPQSSLPPPAQRLQE-PLVPVAAPM 1255
                 TP+  + T+      T    P P  P+   P  +  P P    +  P    +AP 
Sbjct: 435  PT---TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 491

Query: 1256 PQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                P P         P+  S  +    A + P++  P+
Sbjct: 492  TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 530



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 62/240 (25%), Positives = 89/240 (37%), Gaps = 69/240 (28%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSR---APSRTPGPPS------AQSSPIDAQP 1090
            T   ++P T    +PT  + P P+ P +P+    AP+ T  P S      A ++P    P
Sbjct: 659  TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 718

Query: 1091 ATPLPQKDPAQPLEPKRPPP--PRPVAPPT--RPAP--PQRPPP---------------- 1128
             TP   K+PA P  PK P P  P+  AP T   PAP  P++P P                
Sbjct: 719  TTP---KEPA-PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 774

Query: 1129 ------------PSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYS 1176
                        P+  + PAPT  +  AP +P T        S P+             +
Sbjct: 775  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT-------------T 821

Query: 1177 TARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236
            T  PT   ++   S P+         L+ E   K  E S     +P    P A  P  ++
Sbjct: 822  TKEPTTIHKSPDESTPE---------LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 872



 Score = 35.8 bits (81), Expect = 0.27
 Identities = 60/293 (20%), Positives = 105/293 (35%), Gaps = 25/293 (8%)

Query: 1021 EVEELLPQHL----QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPS-LPIRPSRA---- 1071
            E EE+  +H     Q SSSS   +S SS+ R       + +   +   L ++ ++     
Sbjct: 109  ESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTK 168

Query: 1072 PSRTPGPPSAQSSPI-----DAQPATPLPQKDPAQPLEPKRPPPPR-PVAPPTRPAPPQR 1125
               TP PP    +       D +  TP    D +     K    P+   A P  P P   
Sbjct: 169  KKPTPKPPVVDEAGSGLDNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRP-SL 223

Query: 1126 PPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR 1185
            PP    ++  + T  +    ++  TT  +    +    +   A    +   T+   + P 
Sbjct: 224  PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPT 283

Query: 1186 AGVISAPQSHARASA---GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPP-PA 1241
            + V++ P   A  +       TP+  + T+     ST   EP        P +   P P 
Sbjct: 284  SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT 343

Query: 1242 QRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                 P  P   P P +  +P   TP +P P +    +  +  S+    ++P+
Sbjct: 344  TTKSAPTTP-KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 395



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 51/254 (20%), Positives = 93/254 (36%), Gaps = 21/254 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGP--VPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            T  +  P TS   +PT ++ P  +   P   +   S  P P + ++SP   +P  P  + 
Sbjct: 805  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP--KEPGVPTTKT 862

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
              A   E       +      R  P      P   +  A T ++    K   TT +    
Sbjct: 863  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 922

Query: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG 1217
             +Q +         P   +T + T    A  ++  +     +     PE  +K  + +  
Sbjct: 923  TTQDTT--------PFKITTLKTT--TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN 972

Query: 1218 S-TFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRS 1276
            S    P+P KP  A  P+    P + +  + +  V  P     P+    T P+  P SR 
Sbjct: 973  SKATTPKPQKPTKA--PKK---PTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRI 1027

Query: 1277 SHSLPSEASSQPQQ 1290
            + ++  + +++P Q
Sbjct: 1028 AEAM-LQTTTRPNQ 1040



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 30/251 (11%)

Query: 969  KSPDWIKNLEEEMSLEKISIALPSS----------TSSTLLGEDAEVAADFDMEGDVDDY 1018
            KSPD       E+S E    AL +S          T +    E    A D   E D+   
Sbjct: 830  KSPD---ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT- 885

Query: 1019 SAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRT 1075
            + E     P+  + ++++   T+ S    T+   + T ++   P   +     + AP  T
Sbjct: 886  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 945

Query: 1076 PGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135
                +  ++ I  +P      KD A   +   P P +P   P +P   ++P         
Sbjct: 946  TTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP--------- 996

Query: 1136 APTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISA-PQS 1194
              T      PK+  T RK      + +P + +A       +T RP   P + ++   P+S
Sbjct: 997  -KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIA--EAMLQTTTRPNQTPNSKLVEVNPKS 1053

Query: 1195 HARASAGRLTP 1205
                 A   TP
Sbjct: 1054 EDAGGAEGETP 1064


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 93.6 bits (231), Expect = 1e-18
 Identities = 66/239 (27%), Positives = 95/239 (39%), Gaps = 18/239 (7%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+  S+P T    +PT ++ P P+ P  P+   ++ P P + +S+P   +   P   K P
Sbjct: 384  TTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKP 443

Query: 1100 AQPLEPKRPPPPRPVAP----PTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            A P  PK P P  P  P    P  PAP  + P P+  + PAPT     APK P  T    
Sbjct: 444  A-PTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKEPAPT-----APKKPAPTTP-- 495

Query: 1156 IGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTPESQSKTSE 1213
                +P+P      P P       PT P  P      +  +  +  A   T  + +   E
Sbjct: 496  ---KEPAPTTP-KEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 551

Query: 1214 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
             S  +T  P P  P+   P     P P    +        P P +  +P   TP +P P
Sbjct: 552  PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTTPKEPAP 610



 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 69/279 (24%), Positives = 104/279 (37%), Gaps = 40/279 (14%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            P+++    T+P     T+P + +PT  + P P+ P  P+    + P P + + +P   + 
Sbjct: 422  PTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTPTTPKEPAPTTKEPAPTTPKE 481

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAP------------PTRPAPPQRPPPPSGARSPAPT 1138
              P   K PA P  PK P P  P  P            P  PAP      P+  + PAPT
Sbjct: 482  PAPTAPKKPA-PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPT 540

Query: 1139 RKEFG------------------APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARP 1180
              +                     PK P  T       + P   A      PA  +T +P
Sbjct: 541  TTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKP 600

Query: 1181 T-IPPRAGVISAPQSHARASAGRLTPESQSKTSETS--KGSTFLPEPLKPQAAFPPQSSL 1237
                P+    + P+  A  +  +LTP +  K + T+  K +   PE L P     P  + 
Sbjct: 601  APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTT 660

Query: 1238 P----PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPP 1272
            P    P   +   P  P   P P +  +P   TP +P P
Sbjct: 661  PEEPAPTTPKAAAPNTP-KEPAPTTPKEPAPTTPKEPAP 698



 Score = 74.7 bits (182), Expect = 5e-13
 Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 32/266 (12%)

Query: 1040 TSPSSSPRTSPCQ-SPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKD 1098
            T+P     T+P + +PT  + P P+    PS    + P P + +S+P   +   P   K 
Sbjct: 485  TAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKS 544

Query: 1099 -PAQPLEP-----KRPPPPRPVAP----PTRPAP-PQRPPPPSGARSPAPTRKEFGAPKS 1147
             P  P EP     K P P  P  P    P +PAP   + P P+  + PAPT  +  AP +
Sbjct: 545  APTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEPAPTTTKKPAPTT 604

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPES 1207
            P           +P+P        P       PT P +    + P+  A  +   L P +
Sbjct: 605  P----------KEPAPTTP-KETAPTTPKKLTPTTPEKLAP-TTPEKPAPTTPEELAPTT 652

Query: 1208 QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP 1267
              + + T+      P P  P+AA P     P P      P  P      +  P    ET 
Sbjct: 653  PEEPTPTTPEE---PAPTTPKAAAPNTPKEPAPT----TPKEPAPTTPKEPAPTTPKETA 705

Query: 1268 PQPPPRSRSSHSLPSEASSQPQQEQP 1293
            P   P+  +  +L   A + P++  P
Sbjct: 706  P-TTPKGTAPTTLKEPAPTTPKKPAP 730



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 58/252 (23%), Positives = 97/252 (38%), Gaps = 35/252 (13%)

Query: 1028 QHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPID 1087
            Q ++ +S+  L  +     + +P ++ T ++GP  + P  P+         P+    P  
Sbjct: 311  QSIEKTSAKDLAPTSKVLAKPTP-KAETTTKGPALTTPKEPT---------PTTPKEPAS 360

Query: 1088 AQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKS 1147
              P  P P    + P  PK P P    + PT P    + P P+  + PAPT      PK 
Sbjct: 361  TTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTP----KEPAPTTTKEPAPT-----TPKE 411

Query: 1148 PGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRLTP 1205
            P  T        +P+P    + P     +T +   P  P+    + P+  A  +    TP
Sbjct: 412  PAPTTT-----KEPAPTTTKSAP-----TTPKEPAPTTPKKPAPTTPKEPAPTTPKEPTP 461

Query: 1206 ESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1265
             +  + + T+K     P P  P+   P     P P    +        P P +  +P+  
Sbjct: 462  TTPKEPAPTTKE----PAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPT 517

Query: 1266 TPPQPPPRSRSS 1277
            TP +P P +  S
Sbjct: 518  TPKEPAPTTTKS 529



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 70/280 (25%), Positives = 108/280 (38%), Gaps = 35/280 (12%)

Query: 1031 QPSSSSGLGTSPSSSPRTSPCQ----SPTISEGPVPSLP--IRPSRAPSRTPGPPSAQSS 1084
            +P+ ++   T+P++  + +P      +PT  E P P+ P  + P+     TP  P  + +
Sbjct: 607  EPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPE-EPA 665

Query: 1085 PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPP----PSGARSPAPTR 1139
            P   + A P   K+PA P  PK P P  P  P PT P       P    P+  + PAPT 
Sbjct: 666  PTTPKAAAPNTPKEPA-PTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPTT 724

Query: 1140 KEFGAPK--SPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHAR 1197
             +  APK  +P TT++               G  P       PT P      + P+  A 
Sbjct: 725  PKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAP-TTPKGTAP 783

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL---PPPAQRLQEPLVPVAAP 1254
             +     P +  K +         P+ L P     P S+    P P    +        P
Sbjct: 784  TTLKEPAPTTPKKPA---------PKELAPTTTKGPTSTTSDKPAPTTPKETAPTTPKEP 834

Query: 1255 MPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
             P +  +P   TP  PPP +       SE S+    ++P+
Sbjct: 835  APTTPKKPAPTTPETPPPTT-------SEVSTPTTTKEPT 867



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 66/264 (25%), Positives = 100/264 (37%), Gaps = 23/264 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIR-----PSRAPSRTPGPPSAQSSPIDAQPATPL 1094
            T+   +P T    +PT  +   P+ P +     P +    TP  P A ++P +  P TP 
Sbjct: 596  TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKP-APTTPEELAPTTP- 653

Query: 1095 PQKDPAQPLEPKRPPPPRPVAP--PTRPAPPQ-RPPPPSGARSPAPTRKEFGAPKSPGTT 1151
             +  P  P EP  P  P+  AP  P  PAP   + P P+  + PAPT  +  AP +P  T
Sbjct: 654  EEPTPTTPEEPA-PTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGT 712

Query: 1152 RKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKT 1211
                +    P+     A    A  +T  PT    +     P           TP+  + T
Sbjct: 713  APTTLKEPAPTTPKKPAPKELAPTTTKEPT----STTCDKPAPTTPKGTAPTTPKEPAPT 768

Query: 1212 SETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
            +         P P  P+   P     P P    ++P     AP    GP       P P 
Sbjct: 769  TPKE------PAPTTPKGTAPTTLKEPAPTTP-KKPAPKELAPTTTKGPTSTTSDKPAPT 821

Query: 1272 PRSRSSHSLPSE-ASSQPQQEQPS 1294
                ++ + P E A + P++  P+
Sbjct: 822  TPKETAPTTPKEPAPTTPKKPAPT 845



 Score = 67.4 bits (163), Expect = 8e-11
 Identities = 67/279 (24%), Positives = 99/279 (35%), Gaps = 26/279 (9%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            +E+   + L P+S      +P +   T      T  E P P+ P  P+    + P P + 
Sbjct: 313  IEKTSAKDLAPTSKVLAKPTPKAETTTKGPALTTPKE-PTPTTPKEPASTTPKEPTPTTI 371

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAP-PTRPAPPQRPPPPSGARSPAPTRK 1140
            +S+P    P  P P    + P  PK P P     P PT P    + P P+  + PAPT  
Sbjct: 372  KSAP--TTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTP----KEPAPTTTKEPAPTTT 425

Query: 1141 EFG--APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA 1198
            +     PK P  T       + P        P P       PT P       AP +   A
Sbjct: 426  KSAPTTPKEPAPTTPKKPAPTTPKE------PAPTTPKEPTPTTPKEP----APTTKEPA 475

Query: 1199 SAGRLTPESQSKTSETSKGSTFL--PEPLKPQAAFPPQSSLPPPAQRLQE-PLVPVAAPM 1255
                 TP+  + T+      T    P P  P+   P  +  P P    +  P    +AP 
Sbjct: 476  PT---TPKEPAPTAPKKPAPTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPT 532

Query: 1256 PQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                P P         P+  S  +    A + P++  P+
Sbjct: 533  TTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPT 571



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 62/240 (25%), Positives = 89/240 (37%), Gaps = 69/240 (28%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSR---APSRTPGPPS------AQSSPIDAQP 1090
            T   ++P T    +PT  + P P+ P +P+    AP+ T  P S      A ++P    P
Sbjct: 700  TPKETAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAP 759

Query: 1091 ATPLPQKDPAQPLEPKRPPP--PRPVAPPT--RPAP--PQRPPP---------------- 1128
             TP   K+PA P  PK P P  P+  AP T   PAP  P++P P                
Sbjct: 760  TTP---KEPA-PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTS 815

Query: 1129 ------------PSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYS 1176
                        P+  + PAPT  +  AP +P T        S P+             +
Sbjct: 816  DKPAPTTPKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPT-------------T 862

Query: 1177 TARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236
            T  PT   ++   S P+         L+ E   K  E S     +P    P A  P  ++
Sbjct: 863  TKEPTTIHKSPDESTPE---------LSAEPTPKALENSPKEPGVPTTKTPAATKPEMTT 913



 Score = 35.8 bits (81), Expect = 0.27
 Identities = 60/293 (20%), Positives = 105/293 (35%), Gaps = 25/293 (8%)

Query: 1021 EVEELLPQHL----QPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPS-LPIRPSRA---- 1071
            E EE+  +H     Q SSSS   +S SS+ R       + +   +   L ++ ++     
Sbjct: 150  ESEEITEEHSVSENQESSSSSSSSSSSSTIRKIKSSKNSAANRELQKKLKVKDNKKNRTK 209

Query: 1072 PSRTPGPPSAQSSPI-----DAQPATPLPQKDPAQPLEPKRPPPPR-PVAPPTRPAPPQR 1125
               TP PP    +       D +  TP    D +     K    P+   A P  P P   
Sbjct: 210  KKPTPKPPVVDEAGSGLDNGDFKVTTP----DTSTTQHNKVSTSPKITTAKPINPRP-SL 264

Query: 1126 PPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR 1185
            PP    ++  + T  +    ++  TT  +    +    +   A    +   T+   + P 
Sbjct: 265  PPNSDTSKETSLTVNKETTVETKETTTTNKQTSTDGKEKTTSAKETQSIEKTSAKDLAPT 324

Query: 1186 AGVISAPQSHARASA---GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPP-PA 1241
            + V++ P   A  +       TP+  + T+     ST   EP        P +   P P 
Sbjct: 325  SKVLAKPTPKAETTTKGPALTTPKEPTPTTPKEPASTTPKEPTPTTIKSAPTTPKEPAPT 384

Query: 1242 QRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
                 P  P   P P +  +P   TP +P P +    +  +  S+    ++P+
Sbjct: 385  TTKSAPTTP-KEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPA 436



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 51/254 (20%), Positives = 93/254 (36%), Gaps = 21/254 (8%)

Query: 1040 TSPSSSPRTSPCQSPTISEGP--VPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            T  +  P TS   +PT ++ P  +   P   +   S  P P + ++SP   +P  P  + 
Sbjct: 846  TPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSAEPTPKALENSP--KEPGVPTTKT 903

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
              A   E       +      R  P      P   +  A T ++    K   TT +    
Sbjct: 904  PAATKPEMTTTAKDKTTERDLRTTPETTTAAPKMTKETATTTEKTTESKITATTTQVTST 963

Query: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG 1217
             +Q +         P   +T + T    A  ++  +     +     PE  +K  + +  
Sbjct: 964  TTQDTT--------PFKITTLKTT--TLAPKVTTTKKTITTTEIMNKPEETAKPKDRATN 1013

Query: 1218 S-TFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRS 1276
            S    P+P KP  A  P+    P + +  + +  V  P     P+    T P+  P SR 
Sbjct: 1014 SKATTPKPQKPTKA--PKK---PTSTKKPKTMPRVRKPKTTPTPRKMTSTMPELNPTSRI 1068

Query: 1277 SHSLPSEASSQPQQ 1290
            + ++  + +++P Q
Sbjct: 1069 AEAM-LQTTTRPNQ 1081



 Score = 31.2 bits (69), Expect = 6.7
 Identities = 54/251 (21%), Positives = 91/251 (36%), Gaps = 30/251 (11%)

Query: 969  KSPDWIKNLEEEMSLEKISIALPSS----------TSSTLLGEDAEVAADFDMEGDVDDY 1018
            KSPD       E+S E    AL +S          T +    E    A D   E D+   
Sbjct: 871  KSPD---ESTPELSAEPTPKALENSPKEPGVPTTKTPAATKPEMTTTAKDKTTERDLRT- 926

Query: 1019 SAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRT 1075
            + E     P+  + ++++   T+ S    T+   + T ++   P   +     + AP  T
Sbjct: 927  TPETTTAAPKMTKETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVT 986

Query: 1076 PGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135
                +  ++ I  +P      KD A   +   P P +P   P +P   ++P         
Sbjct: 987  TTKKTITTTEIMNKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKP--------- 1037

Query: 1136 APTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISA-PQS 1194
              T      PK+  T RK      + +P + +A       +T RP   P + ++   P+S
Sbjct: 1038 -KTMPRVRKPKTTPTPRKMTSTMPELNPTSRIA--EAMLQTTTRPNQTPNSKLVEVNPKS 1094

Query: 1195 HARASAGRLTP 1205
                 A   TP
Sbjct: 1095 EDAGGAEGETP 1105


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 80/283 (28%), Positives = 104/283 (36%), Gaps = 30/283 (10%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI 1086
            P    PS   GL T P     T+P  +P   +G + + P  P  AP+     P +    +
Sbjct: 1106 PAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP--PKGAPTTPAATPPSPKGGL 1163

Query: 1087 DAQPATPLPQKDPAQPLEPKRP-PPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAP 1145
               P    P    A P  PK     P P   PT PA    P P  G  +P+P     GAP
Sbjct: 1164 ATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP-PSPKGGLATPSPK----GAP 1218

Query: 1146 KSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVISAPQSHARASAGRL 1203
             +P  T         PSP+ GLA P P G  T     P  P+ G  + P   A       
Sbjct: 1219 TTPAAT--------PPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAAT 1270

Query: 1204 TPESQ-SKTSETSKGS-----TFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQ 1257
             P  +    +   KG+        P P    A  PP+ +  PPA     P      P P+
Sbjct: 1271 PPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPK 1330

Query: 1258 SGPQPNLETPPQP------PPRSRSSHSLPSEASSQPQQEQPS 1294
              P P   TPP P      P  + SS   P+  SS+     P+
Sbjct: 1331 GAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPA 1373



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 79/297 (26%), Positives = 107/297 (36%), Gaps = 40/297 (13%)

Query: 1034 SSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATP 1093
            S  G  T P+++P +      T S    P+ P     +P   P  PS + +P       P
Sbjct: 935  SPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATPP 994

Query: 1094 LPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPP------------PPSGARSPAPTRKE 1141
             P+  PA P  PK  P P  V PP+    P   P            PPS   SPA T   
Sbjct: 995  SPKGGPATP-SPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLP 1053

Query: 1142 FGAPKSPGTTRKDNIG---------------RSQPSPQAGLAGPGPAGYSTARPTIP--P 1184
             GAP +P  T     G                + PSP+ G A P P G        P  P
Sbjct: 1054 KGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSP 1113

Query: 1185 RAGVISAPQSHARASAGRLTPESQS-------KTSETSKGSTFLPEPLKPQAAFPPQSSL 1237
            + G+ + P   A  +     P  +        K + T+  +T  P P    A  PP+ + 
Sbjct: 1114 KGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT-PPSPKGGLATPPPKGAP 1172

Query: 1238 PPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
              PA     P   +A P P+  P     TPP   P+   +   P  A + P    PS
Sbjct: 1173 TTPAATPPSPKGGLATPSPKGAPTTPAATPPS--PKGGLATPSPKGAPTTPAATPPS 1227



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 82/298 (27%), Positives = 102/298 (34%), Gaps = 62/298 (20%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLP--------------------- 1065
            P  + P S  G+   P  +P  S    P   EGP    P                     
Sbjct: 867  PSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPA 926

Query: 1066 ---IRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAP 1122
               I  S +P   P PP+A        PATP P+  P     P    PP P   P  P+P
Sbjct: 927  PKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPT----PPAATPPSPKGGPATPSP 982

Query: 1123 PQRPPPPSGARSPAP-----TRKEFGAPKSPGTTRKDNIGRSQPSPQAG-LAGPGPAGYS 1176
               P PP+ A  P+P     T    GAP  P  T         PSP+    A P P G S
Sbjct: 983  KGAPTPPA-ATPPSPKGGPATPSPKGAPTPPAVT--------PPSPKGSPAATPFPKGAS 1033

Query: 1177 TARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSS 1236
            T     PP A   S   S A     +  P + + T  + KG      P  P     P   
Sbjct: 1034 T-----PPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGG-----PATPSLKGAP--- 1080

Query: 1237 LPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQP-----PPRSRSSHSLPSEASSQPQ 1289
              PPA     P    A P P+  P P   TPP P      P  + + + P+     P+
Sbjct: 1081 -TPPAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPK 1137



 Score = 76.6 bits (187), Expect = 1e-13
 Identities = 82/303 (27%), Positives = 112/303 (36%), Gaps = 63/303 (20%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQS-PTISEGPVPSLPIRPSRAPSRTPGPPSAQSSP 1085
            P  + P S  G  T P+++P +    + P+  EGP P     P+  PS   GP     SP
Sbjct: 1335 PPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTP-----PAATPSHKGGPAMTPPSP 1389

Query: 1086 IDAQPATPLPQKDPAQP----LEPKR--------------------PPPPRPVA---PPT 1118
                PA P P+ DP  P    L PK+                    PP   PV+    P 
Sbjct: 1390 -KRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPA 1448

Query: 1119 RPAPPQRPPPPSGARSPA------PTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGP 1172
              AP   P  PS    P       P+ KE  APK   T+          SP+   A P P
Sbjct: 1449 TSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSS---------SPKKAPATPAP 1499

Query: 1173 AGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKP-QAAF 1231
             G     PT+P  A + S+P+      + R  P + + T  + K     P  L P +A  
Sbjct: 1500 MG----APTLP--AVIPSSPKEVPATPSSRRDPIAPTATLLSKK----TPATLAPKEALI 1549

Query: 1232 PPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQE 1291
            PP  ++P P    + P +P     P +       +PP   P +      P E    P   
Sbjct: 1550 PPAMTVPSPK---KTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVT 1606

Query: 1292 QPS 1294
             PS
Sbjct: 1607 SPS 1609



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 73/263 (27%), Positives = 90/263 (34%), Gaps = 44/263 (16%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG----PVPS-LPIRPSRAPSR------T 1075
            P    PS   GL T P     T+P  +P   +G    P P   P  P+  P        T
Sbjct: 1152 PAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLAT 1211

Query: 1076 PGPPSAQSSPIDAQP------ATPLPQKDPAQPLEPKRPPPPRPVAPPTR--PAPPQRPP 1127
            P P  A ++P    P      ATP P+  P  P      P   P  PP +  P PP   P
Sbjct: 1212 PSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATP 1271

Query: 1128 PPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAG 1187
            P        P  K  GAP     T         PSP+ G A   P G  T     PP   
Sbjct: 1272 PSLKGGLATPPHK--GAPNPAVVT--------PPSPKGGPATSPPKGAPTPPAATPP--- 1318

Query: 1188 VISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEP 1247
               +P+        +  P   + T  + KG+  LP      A  P     P      + P
Sbjct: 1319 ---SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLP------ATTPSSKGGPTTPSSKEGP 1369

Query: 1248 LVPVAAPMPQSGPQPNLETPPQP 1270
              P A P  + GP     TPP P
Sbjct: 1370 TPPAATPSHKGGP---AMTPPSP 1389



 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 73/273 (26%), Positives = 104/273 (38%), Gaps = 38/273 (13%)

Query: 1027 PQHLQPSSSSGLGTSPS-----SSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            PQ  +P +  G     +     SSP  SP ++  + E  +     + S A + +P PPS 
Sbjct: 803  PQTKRPPTKKGSAGPDTPIGNLSSP-VSPVEASFLPENSLSFQGSKDSPATTHSPTPPSP 861

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKE 1141
            + +P  +   TPL  K    P  PK  P P  V           P P  G  +PAP +  
Sbjct: 862  KGAPTPS-AVTPLSPKGVTLP--PKETPTPSVV---------NLPFPKEGPATPAPKQ-- 907

Query: 1142 FGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAG 1201
              AP    T+      R+ P+P+   A P P G  T     PP      +P+      + 
Sbjct: 908  --APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPP------SPKGGPATPSP 959

Query: 1202 RLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQ 1261
            +  P   + T  + KG    P          P+ +  PPA     P    A P P+  P 
Sbjct: 960  KWAPTPPAATPPSPKGGPATPS---------PKGAPTPPAATPPSPKGGPATPSPKGAPT 1010

Query: 1262 PNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
            P   TPP  P  S ++   P  AS+ P    PS
Sbjct: 1011 PPAVTPPS-PKGSPAATPFPKGASTPPAATPPS 1042



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 77/283 (27%), Positives = 104/283 (36%), Gaps = 34/283 (12%)

Query: 1027 PQHLQPSSSSGLGTSP-SSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSP 1085
            P    PS   GL T P   +P  +    P+   GP  S        P   P PP+A    
Sbjct: 1267 PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATS-------PPKGAPTPPAATPPS 1319

Query: 1086 IDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAP 1145
                P TP P+  P     P    PP P   PT PA      P S      P+ KE   P
Sbjct: 1320 PKGSPGTPPPKGAPT----PPAVTPPSPKGTPTLPA----TTPSSKGGPTTPSSKEGPTP 1371

Query: 1146 KSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP--PRAGVIS--APQSHARASAG 1201
             +   + K     + PSP+ G A P P G  T+   IP  P+    +    +  A  S G
Sbjct: 1372 PAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKG 1431

Query: 1202 RLTPESQSKTSETSKGSTFLPE--PLKPQ--------AAFPPQSSLPPPAQRLQEPLVPV 1251
             LTP + +  S     +T  P+  P  P         A  PP    PP  +++     P 
Sbjct: 1432 DLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPK 1491

Query: 1252 AAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
             AP   + P P +  P  P     S   +P+  SS+     P+
Sbjct: 1492 KAP---ATPAP-MGAPTLPAVIPSSPKEVPATPSSRRDPIAPT 1530



 Score = 63.2 bits (152), Expect = 2e-09
 Identities = 75/269 (27%), Positives = 103/269 (38%), Gaps = 50/269 (18%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI 1086
            P   +P +   + TS  SSP+ +P     +     P+LP     +P   P  PS++  PI
Sbjct: 1473 PSPKEPPAPKQVATS--SSPKKAPATPAPMG---APTLPAVIPSSPKEVPATPSSRRDPI 1527

Query: 1087 DAQPATPLPQKDPAQPLEPKR---------PPPPRPVAPPTRPAPPQRPPPPSGARSPAP 1137
             A  AT L +K PA  L PK          P P +  A PT    P  P     +  PA 
Sbjct: 1528 -APTATLLSKKTPAT-LAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAV 1585

Query: 1138 TRKEF-GAPK------SPGTTRKD------NIGRSQPSPQAGLAGPGPAGYSTARPTIPP 1184
            T   + GAP        P  T             + PSP+ G A P P G  T+ P  P 
Sbjct: 1586 TPSTYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTP- 1644

Query: 1185 RAGVISAPQSHARASA--GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQ 1242
             + +  +P S A  +   G   P++ SK     KG T L E L   A   P+S+      
Sbjct: 1645 -SSLKDSPTSPASVTCKMGATVPQA-SKGLPAKKGPTALKEVLVAPA---PEST------ 1693

Query: 1243 RLQEPLVPVAAPMPQSGPQPNLETPPQPP 1271
                   P+     + GPQ    +   PP
Sbjct: 1694 -------PIITAPTRKGPQTKKSSATSPP 1715



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 72/286 (25%), Positives = 102/286 (35%), Gaps = 48/286 (16%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQSPTISEG-PVPSLPIRPSRAPSRTPGPPSAQSSPIDAQP 1090
            P+      T  S    + P  +P+  +G P P   + P    S     PS + +P     
Sbjct: 1565 PTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTS-----PSPKEAPTPPAV 1619

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGT 1150
              P P+K PA P  PK  P   PV P +    P  P   +        +   G P   G 
Sbjct: 1620 TPPSPEKGPATPA-PKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP 1678

Query: 1151 TR-KDNIGRSQPSPQAGLAGPGPAGYSTARP--TIPPRAGVISAPQSHARASAGRLTPES 1207
            T  K+ +    P     +  P   G  T +   T PP    I    S    S G L+  +
Sbjct: 1679 TALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPP----ICPDPSAKNGSKGPLSTVA 1734

Query: 1208 -------QSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVA----APMP 1256
                   Q  +S+T+KG           A+  P+  L PP  +   PL   A     P P
Sbjct: 1735 PAPLLPVQKDSSKTAKGK---------DASHSPKGPLAPPESKASTPLTAAAFEKVLPKP 1785

Query: 1257 QS-----GPQPNLETP------PQPPPRSR---SSHSLPSEASSQP 1288
            +S      P P +  P      P  PP+ +   SS  L  E+ S+P
Sbjct: 1786 ESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKP 1831



 Score = 52.0 bits (123), Expect = 4e-06
 Identities = 57/224 (25%), Positives = 80/224 (35%), Gaps = 33/224 (14%)

Query: 1078 PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAP 1137
            P + Q  P        LP             P P  + PP  PAP Q P   +   SP P
Sbjct: 10   PATEQELPQPQAETAVLPMSSALSVTAALGQPGPT-LPPPCSPAPQQCPLSAANQASPFP 68

Query: 1138 TRKEFGA--------PKSPGTTRKDNIGRSQPSPQAGLAGP--GPAGYSTARPTIPPRAG 1187
            +     +          S GT          P+    L GP   PA  + A P I P   
Sbjct: 69   SPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIAPT-- 126

Query: 1188 VISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQE- 1246
            +   P S A  +   L P S  K+S                 AFPP     PP+  + E 
Sbjct: 127  LKGTPSSSAPLALVALAPHSVQKSS-----------------AFPPNLLTSPPSVAVAES 169

Query: 1247 -PLVPVAAPMPQSGPQPNL-ETPPQPPPRSRSSHSLPSEASSQP 1288
              ++ ++AP+  S P+ NL + P +  P  + + S P   S+ P
Sbjct: 170  GSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGTPSPPCIVSTVP 213



 Score = 38.9 bits (89), Expect = 0.032
 Identities = 62/236 (26%), Positives = 91/236 (38%), Gaps = 42/236 (17%)

Query: 1038 LGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQK 1097
            +  +P+++   + C SP +S GP+ +  I P+ +P+     P A   P   Q AT L   
Sbjct: 449  IAAAPTTTFEVATCVSPPMSSGPISN--IEPT-SPAALVMAPVAPKEP-STQVATTL--- 501

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEF--------GAPKSPG 1149
                           PV+PP  P P      PS      PT+K+         GAP SP 
Sbjct: 502  -------------RIPVSPPL-PDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPA 547

Query: 1150 ----TTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTP 1205
                TT+KD      P  QA          +++ P IP     +S   + A+ S G   P
Sbjct: 548  QAGLTTKKD--PTVLPLVQAAPKNSPSFQSTSSSPEIP-----LSPEATLAKKSLGEPLP 600

Query: 1206 ESQSKTSETSK-GSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGP 1260
              +  +S TS  G       +K  +   P S+ P     L  P V  A P+  + P
Sbjct: 601  IGKPASSMTSPLGVNSSASVIKTDSYAGPDSAGPLLKSSLITPTV-AAFPLESADP 655



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 47/180 (26%), Positives = 76/180 (42%), Gaps = 25/180 (13%)

Query: 988  IALPSSTSSTLLGEDAEVA-----ADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSP 1042
            + +   +S T  G+DA  +     A  + +      +A  E++LP+   P S+S      
Sbjct: 1739 LPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPK---PESAS-----V 1790

Query: 1043 SSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQP 1102
            S++P  SP  S  ++  PVP+LP +    PS +PG        +   P+ PL   D  + 
Sbjct: 1791 SAAP--SPPVSLPLAPSPVPTLPPKQQFLPS-SPG-------LVLESPSKPLAPADEDE- 1839

Query: 1103 LEPKRPPPPRPVAPPTRPAPPQRPPPPS-GARSPAPTRKEFGAPKSPGTTRKDNIGRSQP 1161
            L P  PP P     P +      P P S G   P P+ K+     + G+  + +   S P
Sbjct: 1840 LLPLIPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVP 1899



 Score = 34.7 bits (78), Expect = 0.61
 Identities = 74/340 (21%), Positives = 106/340 (31%), Gaps = 66/340 (19%)

Query: 979  EEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSA--EVEELLPQHLQPSSSS 1036
            ++  L   + A P  + ST+     EV       G         E    LP  + P    
Sbjct: 54   QQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPP--- 110

Query: 1037 GLGTSPSSSPRTSPCQSPTISEGPVPSLPIR-----PSRAPSRTPGPPSAQSSPID---A 1088
                SP++    SP  +PT+   P  S P+      P      +  PP+  +SP     A
Sbjct: 111  ---ISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVA 167

Query: 1089 QPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPP------------------S 1130
            +  + +    P  P EPK       V     P P   P PP                  S
Sbjct: 168  ESGSVITLSAPIAPSEPKTNL--NKVPSEVVPNPKGTPSPPCIVSTVPYHCVTPMASIQS 225

Query: 1131 GARS----PAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGP--GPAGYSTARPTIP- 1183
            G  S       T     +P+   TT    +   Q      L GP   PA  S +  ++P 
Sbjct: 226  GVASLPQTTPTTTLAIASPQVKDTTISSVLISPQNPGSLSLKGPVSPPAALSLSTQSLPV 285

Query: 1184 ----PRAGVISAPQSHARASAGRLTPESQSKTSETS----KGSTFLPEPL---------K 1226
                 +    + P     +    L P  QS           G + L +P           
Sbjct: 286  VTSSQKTAGPNTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSS 345

Query: 1227 PQAAFPPQSSLPPPAQRLQEPL------VPVAAPMPQSGP 1260
              A++P Q S+ PP     E +       PV AP    GP
Sbjct: 346  TGASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGP 385


>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
            preproprotein [Homo sapiens]
          Length = 331

 Score = 89.7 bits (221), Expect = 2e-17
 Identities = 83/284 (29%), Positives = 107/284 (37%), Gaps = 36/284 (12%)

Query: 1035 SSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPP-----SAQSSPI 1086
            SS    +   S   SP       +GP P   + P  P   P +  GPP       Q  P 
Sbjct: 14   SSAQNLNEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPP 73

Query: 1087 DAQPATPLPQKDPAQ-----PLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGARSPAPT 1138
              +P  P PQ D ++     P +P+ PPP    +P  PP  P  PQ PPP  G R   P 
Sbjct: 74   PGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQGPP 133

Query: 1139 RKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARA 1198
                G P+ P    + +  RS  SP     GP P G +  +   PP       P    + 
Sbjct: 134  PP--GKPQGP--PPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKK 189

Query: 1199 SAG------RLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVA 1252
              G         P  Q   S +S+     P+   PQ    PQ   PPP +    P  P  
Sbjct: 190  PQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPP--PQG 247

Query: 1253 APMPQSGPQPNLETPPQPPP-----RSRSSHSLPSEASSQPQQE 1291
               PQ  P P     PQ PP     +S+S+ S P +    PQQE
Sbjct: 248  GNKPQGPPPPG---KPQGPPAQGGSKSQSARSPPGKPQGPPQQE 288



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 76/267 (28%), Positives = 99/267 (37%), Gaps = 32/267 (11%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQSPTISEGPVP---SLPIRPSRAPSRTPGPPSA-----QS 1083
            P      G  P      SP   P   +GP P   + P  P   P +  GPP       Q 
Sbjct: 72   PPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNRPQG 131

Query: 1084 SPIDAQPATPLPQKDPAQ-----PLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGAR-- 1133
             P   +P  P PQ D ++     P +P+ PPP    +P  PP  P  PQ PPP  G +  
Sbjct: 132  PPPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQ 191

Query: 1134 SPAPTRKEFGAPKSPGTTRKDNI--GRSQ-PSPQAGLAGPGPAGYSTARPTIPPRAGVIS 1190
             P P  K  G P     +R      G+ Q P PQ G    GP          PP+ G  +
Sbjct: 192  GPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG--N 249

Query: 1191 APQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVP 1250
             PQ        +  P      S++++     P+    Q    PQ   PP     Q+P  P
Sbjct: 250  KPQGPPPPGKPQGPPAQGGSKSQSARSPPGKPQGPPQQEGNNPQGPPPPAGGNPQQPQAP 309

Query: 1251 VAAPMPQSGPQPNLETPPQPPPRSRSS 1277
             A        QP  + PP+PP   R S
Sbjct: 310  PAG-------QP--QGPPRPPQGGRPS 327



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 73/240 (30%), Positives = 87/240 (36%), Gaps = 55/240 (22%)

Query: 1080 SAQSSP--IDAQPATPLPQ---KDPAQPLEPKRP--PPPRPVAPPTRPAPPQRP--PPPS 1130
            S + SP  I   P  P PQ   K    P  P +P  PPP+    P  P PP +P  PPP 
Sbjct: 24   SQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQ 83

Query: 1131 GARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVIS 1190
            G +S +P R   G P+ P   +  N  +  P P     GP P G +  RP  PP  G   
Sbjct: 84   GDKSRSP-RSPPGKPQGP-PPQGGNQPQGPPPPPGKPQGPPPQGGN--RPQGPPPPGKPQ 139

Query: 1191 APQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVP 1250
             P      S    +P                  P KPQ          PP Q   +P  P
Sbjct: 140  GPPPQGDKSRSPRSP------------------PGKPQ---------GPPPQGGNQPQGP 172

Query: 1251 VAAPMPQSGPQPNLETPPQPPP-------------RSRSSHSLPSEASSQPQQ--EQPSG 1295
               P    GP P     PQ PP             +SRSS S P +    P Q   QP G
Sbjct: 173  PPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGDKSRSSQSPPGKPQGPPPQGGNQPQG 232



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 47/162 (29%), Positives = 59/162 (36%), Gaps = 14/162 (8%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPI 1086
            PQ   P      G  P    +      P   +GP P      SR+    PG P       
Sbjct: 169  PQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPPQGD--KSRSSQSPPGKPQGPPPQG 226

Query: 1087 DAQPATPLPQKDPAQPLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1143
              QP  P     P  P +P+ PPP    +P  PP  P  PQ PP   G++S +  R   G
Sbjct: 227  GNQPQGP-----PPPPGKPQGPPPQGGNKPQGPPP-PGKPQGPPAQGGSKSQS-ARSPPG 279

Query: 1144 APKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPR 1185
             P+ P     +N     P P AG     P      +P  PPR
Sbjct: 280  KPQGPPQQEGNN--PQGPPPPAGGNPQQPQAPPAGQPQGPPR 319


>gi|7706501 WW domain binding protein 11 [Homo sapiens]
          Length = 641

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 90/306 (29%), Positives = 135/306 (44%), Gaps = 30/306 (9%)

Query: 975  KNLEEEMSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSS 1034
            KN++E   L+ + + +         G + E  ++ D E D DD  AE ++   QH + S 
Sbjct: 322  KNMKELTPLQAMMLRMAGQEIPEE-GREVEEFSEDDDEDDSDDSEAE-KQSQKQHKEESH 379

Query: 1035 SSGLGTSPSSSPRTSPCQSPTISE------------GPVPSLPIRPSRAPSRTPGPPSAQ 1082
            S G  TS +SS + +P QS   S+            GP P+ P+RP   P+  P  P   
Sbjct: 380  SDG--TSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGPPPAPPLRPPGPPTGLPPGPPPG 437

Query: 1083 SSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRP-PPPSG--ARSPAPTR 1139
            + P    P  P   + P   L P  PPP RP  PP  P P   P PPP G   R P P  
Sbjct: 438  APPFLRPPGMP-GLRGPLPRLLPPGPPPGRPPGPPPGPPPGLPPGPPPRGPPPRLPPPAP 496

Query: 1140 KEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGP---AGYSTARPTI--PPRAGVISAPQS 1194
                 P+ PG  R   +    P+P  GL  P P    G  +A P +   P+A   SA   
Sbjct: 497  PGIPPPR-PGMMRPPLVPPLGPAP-PGLFPPAPLPNPGVLSAPPNLIQRPKADDTSAATI 554

Query: 1195 HARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAP 1254
              +A+A  ++ + Q  T+  ++ + F+P  L+ +      ++  P  +   +  VP+A  
Sbjct: 555  EKKATA-TISAKPQI-TNPKAEITRFVPTALRVRRE-NKGATAAPQRKSEDDSAVPLAKA 611

Query: 1255 MPQSGP 1260
             P+SGP
Sbjct: 612  APKSGP 617



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 48/176 (27%), Positives = 51/176 (28%), Gaps = 71/176 (40%)

Query: 1098 DPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIG 1157
            D       ++  PP+ V P    APP   PPP G   PAP       P  P         
Sbjct: 381  DGTSTASSQQQAPPQSVPPSQIQAPPMPGPPPLGP-PPAP-------PLRP--------- 423

Query: 1158 RSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG 1217
               P P  GL  PGP       P  PP                                 
Sbjct: 424  ---PGPPTGLP-PGPP------PGAPP--------------------------------- 440

Query: 1218 STFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPR 1273
              FL  P  P    P    LPP          P   P P  GP P L  PP PPPR
Sbjct: 441  --FLRPPGMPGLRGPLPRLLPPGPP-------PGRPPGPPPGPPPGL--PPGPPPR 485



 Score = 30.8 bits (68), Expect = 8.8
 Identities = 21/71 (29%), Positives = 28/71 (39%), Gaps = 6/71 (8%)

Query: 1060 PVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLE------PKRPPPPRP 1113
            P+P +P  PS    +    P AQ   I  + +   P       L       P+ PP  +P
Sbjct: 140  PLPDMPHAPSNILIQDIPLPGAQPPSILKKTSAYGPPTRAVSILPLLGHGVPRLPPGRKP 199

Query: 1114 VAPPTRPAPPQ 1124
              PP  P PPQ
Sbjct: 200  PGPPPGPPPPQ 210


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 74/258 (28%), Positives = 97/258 (37%), Gaps = 20/258 (7%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+PS  P T+P   PT +    P+    P    + TP P +  S PI     TP P   P
Sbjct: 1397 TTPSP-PTTTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTT-TTPPPTTTP 1454

Query: 1100 AQPLEPKRPPPP--RPVAPPTRPAPPQR--PPPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            + P+     PPP   P  P T P+PP     PP +   +P PT      P  P TT    
Sbjct: 1455 SPPISTTTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTT----TPSPPTTTPITP 1510

Query: 1156 IGRSQPSPQAGLAGPGPAGYSTARPTI---PPRAGVISAPQSHARASAGRLTPESQSKTS 1212
               +   P      P     +T  PT    PP    I+ P S    +    T  S   T+
Sbjct: 1511 PASTTTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPTS--TTTLPPTTTPSPPPTT 1568

Query: 1213 ETSKGSTFLPEPLKPQAAFPP--QSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQP 1270
             T+   T  P P       PP   ++ PPP      P      P P + P P   TP  P
Sbjct: 1569 TTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP 1628

Query: 1271 PPRSRSSHSLPSEASSQP 1288
            P    S+ +LP   +  P
Sbjct: 1629 P---TSTTTLPPTTTPSP 1643



 Score = 81.3 bits (199), Expect = 6e-15
 Identities = 73/288 (25%), Positives = 106/288 (36%), Gaps = 32/288 (11%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPP-SAQSSPIDAQP 1090
            P+S++ L  + + SP T+   +P  +  P P +    +  P+ TP PP S  ++P     
Sbjct: 1410 PTSTTTLPPTTTPSPPTTTTTTPPPTTTPSPPITTTTTPPPTTTPSPPISTTTTPPPTTT 1469

Query: 1091 ATPLPQKDPAQPLEPKRPPPPRPVAPP--TRPAPPQRPP--PPSGARSPAPTRKEFGAPK 1146
             +P P   P+ P     PP      PP  T P+PP   P  PP+   +  PT      P 
Sbjct: 1470 PSP-PTTTPSPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTT----TPS 1524

Query: 1147 SPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTI---PPRAGVISAPQSHARASAGRL 1203
             P TT       + PSP        P   +T  PT    PP     + P +   +     
Sbjct: 1525 PPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTT 1584

Query: 1204 TPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLP-----------------PPAQRLQE 1246
            TP   + T+ T   +T  P P       PP ++ P                 PP      
Sbjct: 1585 TPSPPTITTTTPPPTT-TPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSP 1643

Query: 1247 PLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEASSQPQQEQPS 1294
            P      P P + P P   T P PP  + ++   P+   S P    PS
Sbjct: 1644 PPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPP-PTTTPSSPITTTPS 1690



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 72/284 (25%), Positives = 101/284 (35%), Gaps = 35/284 (12%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRA-----PSRTPGPPSAQS---------SP 1085
            T+PS    T+    PT +  P  + PI P  +     P+ TP PP+  +         SP
Sbjct: 1482 TTPSPPTTTTTTPPPTTTPSPPTTTPITPPASTTTLPPTTTPSPPTTTTTTPPPTTTPSP 1541

Query: 1086 IDAQPATPLPQKDPAQPLEPKRPPPPRPVAPP--TRPAPPQRP---PPPSGARSPAPTRK 1140
                P TP        P     PPP     PP  T P+PP      PP     +P PT  
Sbjct: 1542 PTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTT- 1600

Query: 1141 EFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTI---PPRAGVISAPQSHAR 1197
                P  P TT       + PSP        P   +T  PT    PP     + P +   
Sbjct: 1601 ---TPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTP 1657

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSL--PPPAQRLQEPLVPVAAPM 1255
            +     TP     T+ T   +T    P+    + PP +++  P P      P+     P 
Sbjct: 1658 SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPS-PPTTTMTTPSPTTTPSSPITTTTTPS 1716

Query: 1256 PQSGPQP---NLETP---PQPPPRSRSSHSLPSEASSQPQQEQP 1293
              + P P    + TP     P P + +  +LP   +S P    P
Sbjct: 1717 STTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTP 1760



 Score = 68.2 bits (165), Expect = 5e-11
 Identities = 70/265 (26%), Positives = 100/265 (37%), Gaps = 48/265 (18%)

Query: 1032 PSSSSGLG--TSPSSSPRTSPCQSPTISEGP----VPSLPIRPSRAP--SRTPGPPSAQS 1083
            P+S++ L   T+PS  P T+    PT +  P     PS P   +  P  + TP PP+  +
Sbjct: 1550 PTSTTTLPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPSPPTTTT 1609

Query: 1084 SPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTR----PAPPQRPPPPSGARSPAPTR 1139
            +       TP P   P+       PP   P+ PPT     P      PPP+   +P PT 
Sbjct: 1610 T-------TPPPTTTPS-------PPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTT 1655

Query: 1140 KEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVIS--APQSHAR 1197
                 P  P TT         PSP            +T  PT  P + + +  +P +   
Sbjct: 1656 ----TPSPPTTT--------TPSPPITTT-------TTPPPTTTPSSPITTTPSPPTTTM 1696

Query: 1198 ASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMP- 1256
             +    T  S   T+ T+  ST  P P       P  ++ P P       L P     P 
Sbjct: 1697 TTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPL 1756

Query: 1257 QSGPQPNLETPPQPPPRSRSSHSLP 1281
             + P P   TPP   P S ++ + P
Sbjct: 1757 TTTPLPPSITPPTFSPFSTTTPTTP 1781



 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 61/218 (27%), Positives = 78/218 (35%), Gaps = 38/218 (17%)

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDP 1099
            T+PS    T+    PT +  P  + PI P    S T  PP+   SP      TP P   P
Sbjct: 1600 TTPSPPTTTTTTPPPTTTPSPPTTTPITPPT--STTTLPPTTTPSPPPTTTTTPPPTTTP 1657

Query: 1100 AQPLEPKRPPP------PRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTTRK 1153
            + P      PP      P P   P+ P      PP +   +P+PT      P SP TT  
Sbjct: 1658 SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTT----TPSSPITTTT 1713

Query: 1154 DNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSE 1213
                 + PSP        P   +T  PT  P         S    +   L P + S    
Sbjct: 1714 TPSSTTTPSPP-------PTTMTTPSPTTTP---------SPPTTTMTTLPPTTTSSPLT 1757

Query: 1214 TSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPV 1251
            T    T LP  + P   F P S+  P       P VP+
Sbjct: 1758 T----TPLPPSITP-PTFSPFSTTTPTT-----PCVPL 1785



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 46/167 (27%), Positives = 62/167 (37%), Gaps = 29/167 (17%)

Query: 1026 LPQHLQPSSSSGLGTSP----SSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1081
            LP    PS      T+P    + SP T+   SP I+    P     PS   + TP PP+ 
Sbjct: 1635 LPPTTTPSPPPTTTTTPPPTTTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTT 1694

Query: 1082 QSSPIDAQPATPLPQKDPAQPLEPKRPP-----PPRPVAPPTRPAPPQRPPPPSGARSPA 1136
              +       TP P   P+ P+     P     P  P    T P+P   P PP+   +  
Sbjct: 1695 TMT-------TPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTL 1747

Query: 1137 PTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIP 1183
            P         SP TT         P P + +  P  + +ST  PT P
Sbjct: 1748 PPT----TTSSPLTT--------TPLPPS-ITPPTFSPFSTTTPTTP 1781



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 53/269 (19%), Positives = 93/269 (34%), Gaps = 23/269 (8%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLP-IRPSRAPSRTPGPPSAQSSP 1085
            P   Q  +++ + T+ + +P  +P  + T +  P+ +   + P+  P+ T  P +   + 
Sbjct: 4075 PTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITT 4134

Query: 1086 IDAQPATPLP---QKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGAR---SPAPTR 1139
                  TP P   Q     P+       P P   PT    P   P  +      +P PT 
Sbjct: 4135 TTTVTPTPTPTGTQTPTTTPITTTTTVTPTPT--PTGTQTPTTTPITTTTTVTPTPTPTG 4192

Query: 1140 KEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARAS 1199
             + G P    T     +  S P P++          ST+ P       + + P +    S
Sbjct: 4193 TQTGPPTHTSTAPIAELTTSNPPPESSTP---QTSRSTSSPLTESTTLLSTLPPAIEMTS 4249

Query: 1200 AGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSG 1259
                 P + +  + TS G T  P         PP ++  PP    +      ++    S 
Sbjct: 4250 TA--PPSTPTAPTTTSGGHTLSP---------PPSTTTSPPGTPTRGTTTGSSSAPTPST 4298

Query: 1260 PQPNLETPPQPPPRSRSSHSLPSEASSQP 1288
             Q    +   P P   S+ S+      +P
Sbjct: 4299 VQTTTTSAWTPTPTPLSTPSIIRTTGLRP 4327



 Score = 32.3 bits (72), Expect = 3.0
 Identities = 48/222 (21%), Positives = 67/222 (30%), Gaps = 16/222 (7%)

Query: 1055 TISEGPVP--SLPIRPSRAPSRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPR 1112
            T +E P P  + PI  +   + TP P   Q+      P T      P       + P   
Sbjct: 1888 TTTENPTPPTTTPITTTTTVTPTPTPTGTQTP--TTTPITTTTTVTPTPTPTGTQTPTTT 1945

Query: 1113 PVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSP-GTTRKDNIGRSQPSPQAGLAGPG 1171
            P+   T   P    P P+G ++P  T        +P  T        + P        P 
Sbjct: 1946 PITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPT 2002

Query: 1172 PAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAF 1231
            P    T  PT  P     +   +      G  TP +   T+ T    T  P P       
Sbjct: 2003 PTPTGTQTPTTTPITTTTTV--TPTPTPTGTQTPTTTPITTTT----TVTPTPTPTGTQT 2056

Query: 1232 PPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLET-PPQPPP 1272
            P  + +         P  P     P + P     T  P P P
Sbjct: 2057 PTTTPITTTTTVTPTP-TPTGTQTPTTTPITTTTTVTPTPTP 2097



 Score = 32.0 bits (71), Expect = 3.9
 Identities = 13/38 (34%), Positives = 21/38 (55%), Gaps = 4/38 (10%)

Query: 1090 PATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPP 1127
            P+TP P   P++      P P +P + P++P P  +PP
Sbjct: 4377 PSTPSPTPTPSK----STPTPSKPSSTPSKPTPGTKPP 4410


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
            sapiens]
          Length = 309

 Score = 84.7 bits (208), Expect = 5e-16
 Identities = 93/327 (28%), Positives = 121/327 (37%), Gaps = 35/327 (10%)

Query: 981  MSLEKISIALPSSTSSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQH-LQPSSSSGLG 1039
            M L  +S+AL + +S+  L ED         E      S + E   PQ   QP  +    
Sbjct: 1    MLLILLSVALLALSSAQSLNEDVS------QEESPSVISGKPEGRRPQGGNQPQRTP--- 51

Query: 1040 TSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAP----SRTPGPPSAQSSPIDAQP-ATPL 1094
              P   P   P Q    S+GP P  P +P   P    +++ GPP     P    P     
Sbjct: 52   -PPPGKPEGRPPQGGNQSQGPPPR-PGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQ 109

Query: 1095 PQKDPAQPLEPKRPPPP---RPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAPKSPGTT 1151
             Q  P +P +P+ PPP    +   PP RP  P+ PPP  G +S  P  +  G P+ P   
Sbjct: 110  SQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRP-GKPEGP-PP 167

Query: 1152 RKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKT 1211
            +  N  +  P       GP P G + ++   PPR G    P       +    P      
Sbjct: 168  QGGNQSQGPPPHPGKPEGPPPQGGNQSQGP-PPRPGKPEGPPPQGGNQSQGPPPRPGKPE 226

Query: 1212 SETSKGSTF----LPEPLKPQAAFPPQS----SLPPPAQRLQEPLVPVAAPMPQSGPQPN 1263
               S+G        P P KPQ   PPQ       PPP  R Q P  P   P     P   
Sbjct: 227  GPPSQGGNKPQGPPPHPGKPQGP-PPQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAG 285

Query: 1264 LETPPQPPPRSRSSHSLPSEASSQPQQ 1290
                P PPP+    H  P     QP Q
Sbjct: 286  KPQGPPPPPQGGRPHRPP---QGQPPQ 309


>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
            sapiens]
          Length = 1636

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 81/308 (26%), Positives = 109/308 (35%), Gaps = 53/308 (17%)

Query: 1032 PSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSAQSSPIDAQPA 1091
            P+ +  LG  P SSP+     SP +  GP P +   PS  P +  GP  A +     +PA
Sbjct: 825  PAYTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMA----VRPA 880

Query: 1092 T--------PLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFG 1143
            T        P+P     +P     PPPP    PP +P P     P +GA+ P P +  F 
Sbjct: 881  TTTVDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQPLPTPYTYP-AGAKQPIPAQHHFS 939

Query: 1144 APKSPGTTRKDNIGRSQPSPQ---AGLAGPGPAGYST-----------ARPTIPPRAGVI 1189
            +    G        + QP PQ   +   GP P                A   +PP++   
Sbjct: 940  SGIPAGFPAPRIGPQPQPHPQPHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYP 999

Query: 1190 SAPQSHARASAG-----RLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRL 1244
             APQ             +L P           G+   P P  PQ   PP +  P P+ R 
Sbjct: 1000 YAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRP 1059

Query: 1245 QEP---------------------LVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSE 1283
              P                     LVP  AP P  GP P      +PPP  R   +    
Sbjct: 1060 MGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADL 1119

Query: 1284 ASSQPQQE 1291
             SS P+ +
Sbjct: 1120 LSSSPESQ 1127



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 63/268 (23%), Positives = 88/268 (32%), Gaps = 21/268 (7%)

Query: 1027 PQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGP-VPSLPIRPSRAPSRTPGPPSAQSSP 1085
            P+ L P             P       P +  GP +P   +  +      P P  + + P
Sbjct: 723  PKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSSTGP 782

Query: 1086 IDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPAPTRKEFGAP 1145
                 + PLP    + P +  +P  P P A P  P P   P P   A +P        +P
Sbjct: 783  GPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAP---AYTPELGLVPRSSP 839

Query: 1146 KSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGV-----ISAPQSHARASA 1200
            +  G      +G     P AGL    P  +S     +  R        I AP     A  
Sbjct: 840  QH-GVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPR 898

Query: 1201 GRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGP 1260
               TP                P+PL     +P  +  P PAQ      +P   P P+ GP
Sbjct: 899  PNPTPAPPPPCFPVPP-----PQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGP 953

Query: 1261 QPNLETPPQPPPRSRSSHSLPSEASSQP 1288
            Q      PQP P+   S +   +   QP
Sbjct: 954  Q------PQPHPQPHPSQAFGPQPPQQP 975



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 56/213 (26%), Positives = 72/213 (33%), Gaps = 38/213 (17%)

Query: 1085 PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRP------------PPPSGA 1132
            P    P   LP+++ ++ +E   PP      PP   A P+ P            PP    
Sbjct: 718  PRPTAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFP 777

Query: 1133 RSPAPTRKEFGAPKSPGTTRKDN--IGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVI- 1189
             S  P       P  PGT       I    P P A    PGPA Y    P   P  G++ 
Sbjct: 778  SSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPA--PAYTPELGLVP 835

Query: 1190 -SAPQ----SHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQSSLPPPA--- 1241
             S+PQ    S      G   P +             LP    PQ + P  +    PA   
Sbjct: 836  RSSPQHGVVSSPYVGVGPAPPVAG------------LPSAPPPQFSGPELAMAVRPATTT 883

Query: 1242 -QRLQEPLVPVAAPMPQSGPQPNLETPPQPPPR 1273
               +Q P+    AP P   P P     P PPP+
Sbjct: 884  VDSIQAPIPSHTAPRPNPTPAPPPPCFPVPPPQ 916



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 44/140 (31%), Positives = 52/140 (37%), Gaps = 31/140 (22%)

Query: 1018 YSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSL-PIRPSRAPSRTP 1076
            Y    ++ LP H      SG    PS  P   P   P ++ GP PS  P+ P  AP    
Sbjct: 1019 YPGPAQDPLPAH------SGALPFPSPGPPQPP--HPPLAYGPAPSTRPMGPQAAPLTIR 1070

Query: 1077 GPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPA 1136
            GP SA  S       TP P   P+        P P P   P  P PP   PPP   R  A
Sbjct: 1071 GPSSAGQS-------TPSPHLVPS--------PAPSPGPGPVPPRPPAAEPPPCLRRGAA 1115

Query: 1137 PT-------RKEFGAPKSPG 1149
                       + G  +SPG
Sbjct: 1116 AADLLSSSPESQHGGTQSPG 1135



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 44/166 (26%), Positives = 53/166 (31%), Gaps = 16/166 (9%)

Query: 1029 HLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVP------------SLPIRPSRAPSRTP 1076
            HL P  + GL   P  SP     Q   + + P P             LP      P  +P
Sbjct: 982  HLFPPQAPGL--LPPQSPYPYAPQPGVLGQPPPPLHTQLYPGPAQDPLPAHSGALPFPSP 1039

Query: 1077 GPPSAQSSPIDAQPA-TPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSP 1135
            GPP     P+   PA +  P    A PL  + P       P     P   P P  G   P
Sbjct: 1040 GPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTPSPHLVPSPAPSPGPGPVPP 1099

Query: 1136 APTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYSTARPT 1181
             P   E       G    D +  S  S   G   PG  G    +PT
Sbjct: 1100 RPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPG-GGQPLLQPT 1144



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 65/203 (32%), Positives = 76/203 (37%), Gaps = 39/203 (19%)

Query: 1104 EPKRPPPPRPVAPPTRPAPPQRP--------PPPSGARSPAPTRKEFGAPKSPGTTRKDN 1155
            E K+ PPPRP AP  +P  P+R          PP   RS  P       P+ P T     
Sbjct: 711  ELKKKPPPRPTAP--KPLLPRREESEAVEAGDPPEELRSLPPDM--VAGPRLPDTFLGSA 766

Query: 1156 IG-RSQPSPQAGLAGPG---------PAGYSTARPTIPPRA-GVISAPQSHARA--SAGR 1202
                  PSP     GPG         P  YS     I PRA G  + P +   A   A  
Sbjct: 767  TPLHFPPSPFPSSTGPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPA 826

Query: 1203 LTPE-SQSKTSETSKGSTFLP----EPLKPQA----AFPPQSSLPPPAQRLQEPLVPV-- 1251
             TPE      S    G    P     P  P A    A PPQ S P  A  ++     V  
Sbjct: 827  YTPELGLVPRSSPQHGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDS 886

Query: 1252 -AAPMP-QSGPQPNLETPPQPPP 1272
              AP+P  + P+PN  TP  PPP
Sbjct: 887  IQAPIPSHTAPRPN-PTPAPPPP 908



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 44/171 (25%), Positives = 62/171 (36%), Gaps = 8/171 (4%)

Query: 1022 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG---PVPSLPIRPSRAPSRTPG- 1077
            VE++L +H  P     L ++  S     P  S  +  G   P+ S+    ++   R PG 
Sbjct: 1453 VEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQATIAKLSIRPPGG 1512

Query: 1078 -PPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGARSPA 1136
                  S P  A+P    P   P     P   PPP     P  P P + PP P    S  
Sbjct: 1513 LESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGP 1572

Query: 1137 PTRK-EFGAPKSPGTTRKDNI--GRSQPSPQAGLAGPGPAGYSTARPTIPP 1184
            P+   E  A  +P     D+   G+ + S    L      G    RP+  P
Sbjct: 1573 PSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPSDDP 1623



 Score = 34.3 bits (77), Expect = 0.79
 Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 2/61 (3%)

Query: 1227 PQAAFPPQSSLP--PPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRSRSSHSLPSEA 1284
            P A+ P  +  P  PPA   +   +P ++P P S P P    P + PP   +  S P  +
Sbjct: 1516 PVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKEEPPVPEAPSSGPPSS 1575

Query: 1285 S 1285
            S
Sbjct: 1576 S 1576



 Score = 33.9 bits (76), Expect = 1.0
 Identities = 24/70 (34%), Positives = 34/70 (48%), Gaps = 4/70 (5%)

Query: 1221 LPEPLKPQAAFPPQSSLPPPAQRLQEPLVPVAAPMPQSGPQPNLETP-PQPPPRSRSSHS 1279
            LP P +P     P +SLP           P+++P+P++ PQP  E P P+ P     S S
Sbjct: 1520 LPGPAEPPGL--PPASLPESTPIPSSSPPPLSSPLPEA-PQPKEEPPVPEAPSSGPPSSS 1576

Query: 1280 LPSEASSQPQ 1289
            L   AS  P+
Sbjct: 1577 LELLASLTPE 1586


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.133    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,844,591
Number of Sequences: 37866
Number of extensions: 3321459
Number of successful extensions: 72890
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 868
Number of HSP's successfully gapped in prelim test: 2448
Number of HSP's that attempted gapping in prelim test: 21670
Number of HSP's gapped (non-prelim): 21049
length of query: 1295
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1181
effective length of database: 13,930,794
effective search space: 16452267714
effective search space used: 16452267714
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.