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Search of human proteins with 116008442
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
(1564 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 3138 0.0
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 246 1e-64
gi|148746195 trichohyalin [Homo sapiens] 196 1e-49
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 195 3e-49
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 191 5e-48
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 185 3e-46
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 183 1e-45
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 166 1e-40
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 158 4e-38
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 158 4e-38
gi|224548936 hypothetical protein LOC100170229 [Homo sapiens] 155 4e-37
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 149 2e-35
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 149 3e-35
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 148 5e-35
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 146 2e-34
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 144 9e-34
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 141 6e-33
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 138 4e-32
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 131 6e-30
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 126 1e-28
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 125 3e-28
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 122 2e-27
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 122 2e-27
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 122 4e-27
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 121 5e-27
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 121 6e-27
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 120 1e-26
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 119 2e-26
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 119 3e-26
gi|52426743 cisplatin resistance-associated overexpressed protei... 118 5e-26
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 3138 bits (8136), Expect = 0.0
Identities = 1564/1564 (100%), Positives = 1564/1564 (100%)
Query: 1 MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV 60
MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV
Sbjct: 1 MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV 60
Query: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR 120
HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR
Sbjct: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR 120
Query: 121 HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL
Sbjct: 121 HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
Query: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV
Sbjct: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
Query: 241 SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR 300
SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR
Sbjct: 241 SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR 300
Query: 301 GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ 360
GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ
Sbjct: 301 GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ 360
Query: 361 RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT 420
RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT
Sbjct: 361 RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT 420
Query: 421 RGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSR 480
RGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSR
Sbjct: 421 RGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSR 480
Query: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR 540
EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR
Sbjct: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR 540
Query: 541 TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS 600
TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS
Sbjct: 541 TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS 600
Query: 601 SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR 660
SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR
Sbjct: 601 SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR 660
Query: 661 EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE 720
EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE
Sbjct: 661 EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE 720
Query: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER
Sbjct: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
Query: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR 840
DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR
Sbjct: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR 840
Query: 841 RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKE 900
RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKE
Sbjct: 841 RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKE 900
Query: 901 SSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKA 960
SSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKA
Sbjct: 901 SSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKA 960
Query: 961 KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE 1020
KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE
Sbjct: 961 KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE 1020
Query: 1021 AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE
Sbjct: 1021 AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
Query: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS 1140
AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS
Sbjct: 1081 AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS 1140
Query: 1141 ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS 1200
ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS
Sbjct: 1141 ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS 1200
Query: 1201 HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS 1260
HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS
Sbjct: 1201 HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS 1260
Query: 1261 RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ 1320
RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ
Sbjct: 1261 RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ 1320
Query: 1321 REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE 1380
REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE
Sbjct: 1321 REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE 1380
Query: 1381 SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE
Sbjct: 1381 SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
Query: 1441 AGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVD 1500
AGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVD
Sbjct: 1441 AGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVD 1500
Query: 1501 WSGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKGS 1560
WSGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKGS
Sbjct: 1501 WSGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKGS 1560
Query: 1561 FILL 1564
FILL
Sbjct: 1561 FILL 1564
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 246 bits (628), Expect = 1e-64
Identities = 159/465 (34%), Positives = 245/465 (52%), Gaps = 43/465 (9%)
Query: 386 QSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445
Q PR R + D + ++ + ERR + R + +RE D + ER E+D+ RD
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKR-QTERETDRKRERRREKDRHRKRD 92
Query: 446 HRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRD-----PRDSRS 500
+R+ RD R+ + R+R R+ R R+ R+ + RD R+
Sbjct: 93 RHRERQ-RDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERER 151
Query: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
RDA R+R+ T R+ E +R R + R E + E+++E R+
Sbjct: 152 QRDAEKERERQ---TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSER 208
Query: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
GR R R R ++ ++ + R + ER++ ER+ +
Sbjct: 209 GRERER-----------ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETE 257
Query: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
R ER+R +R+RD+ R + R + +R +R R DR +R+ ER RER+
Sbjct: 258 ----RDKERERERDRDRDR----DRRQKERERQTDRKRQRRTER-DRETERKRERQRERE 308
Query: 681 RERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD------RDHD 734
RERER+R+RERERERER+RER++E E +RE+ RER+R+R+ E DRER+R R +
Sbjct: 309 RERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAE 368
Query: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWED-- 792
RERERERERDR+ RERE ER+R+R+R++ERER+ E++R+ RE +K+RER++D E
Sbjct: 369 RERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESER 428
Query: 793 -KDKGRDDRREK-REEIREDRNPRDGHDERKSKKRYRNEGSPSPR 835
+++GR+ ++K RE RE + R +RK Y N P PR
Sbjct: 429 GRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVN---PPPR 470
Score = 236 bits (602), Expect = 1e-61
Identities = 168/494 (34%), Positives = 260/494 (52%), Gaps = 75/494 (15%)
Query: 456 RDRRDARDTRDRRELRDSRDMRDSREM-RDYSRDTKESRDPRDSRSTRDAHDYRDREGRD 514
R R ++++ RR L + D + R+ ++ + R+ R + D R RE +D
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRRE-KD 86
Query: 515 THRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKG 574
HRK D + E R E R + R+ R + RN + R R E +G
Sbjct: 87 RHRKRDRHRERQRD-------REKERERQTDRERDRQREKERNRQKERER----ETEREG 135
Query: 575 SRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDN 634
RG R Q D D+ + R +R+R +R ER+R+
Sbjct: 136 ERG-RDRQTDGQRERERQRDAEKERERQTDRER----------------QRQTERNRQKE 178
Query: 635 RERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERE------RDRE 688
RER++ R + ER+ +RE+ ++ +DR ER RER+RERE R R+
Sbjct: 179 REREKN---------RQERRERERQREKE--NKTEDRHSERGRERERERETETETERKRQ 227
Query: 689 RERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKE 748
+RER+R+R ERE+E++ ERERA ERE ER+KER+RERDRDRD DR R++ERER +++
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDR-RQKERERQTDRK 286
Query: 749 REREREERERERERERERERERERERERARERDKERERQRDWE-------DKDKGRDDRR 801
R+R R ER+RE ER+RER+RERERERER R+R++ERER+R+ E D++K R+ +R
Sbjct: 287 RQR-RTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKR 345
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861
+++ E+ +RN + G + R+ +R R RQS + R E D D D + E+
Sbjct: 346 KRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDR----DRQKERE 401
Query: 862 RLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER-KESSRRYEEQELKEKVSSVDKQ 920
R Q + ++ + E + R +E+DR+ ER +E R E+Q+ +E+ D++
Sbjct: 402 R---QTEKDRDGQ-------RETEKQREREKDRESERGRERGREREKQKGRER----DRE 447
Query: 921 REQTEILESSRMRA 934
R+ R R+
Sbjct: 448 RQTDRQAGRQRKRS 461
Score = 226 bits (576), Expect = 1e-58
Identities = 169/540 (31%), Positives = 262/540 (48%), Gaps = 82/540 (15%)
Query: 385 KQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSR 444
++ P SP R +G + + DR R+++ R+R RE+R+ E++ R
Sbjct: 28 RRRPGSQESP-RRRGLGQAHKDADGDDRERNRQKE----RERR---REKRQTERETDRKR 79
Query: 445 DHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDA 504
+ R +++ RDR R RDR + R+ + R+ R+ R+ ++ R+ R
Sbjct: 80 ERRREKDRHRKRDRHRERQ-RDREKERERQTDRERDRQREKERNRQKERERETEREGERG 138
Query: 505 HDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSR 564
D + R+ R+ D E R R R+ RN + R + R +R R R
Sbjct: 139 RDRQTDGQRERERQRDAEKERERQTDRERQRQTE-----RNRQKEREREKNRQERRERER 193
Query: 565 GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER 624
R E + RG R+R ER+ +
Sbjct: 194 QREKENKTEDRHSERG------------------------RERERERETETET------- 222
Query: 625 RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDRER 683
ER R+ +RERD++ R E ER+++ E ER +R +R ER RERDR+R
Sbjct: 223 ---ERKRQTDRERDRQ---------RKTEREREKQAERERASERETERDKERERERDRDR 270
Query: 684 ERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERER 743
+RDR R++ERER+ DR+R++ E +RE R+RER+RE+ER+RER+R R+ +RERERERER
Sbjct: 271 DRDR-RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERER 329
Query: 744 DREKERERERE-ERERERERERERERER----------ERERERARERDKERERQRDWED 792
RE ER+RE+E ER+R+R+ E +RER R ERERER RERD++ R+R+ +
Sbjct: 330 QRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389
Query: 793 KDKGRDDRREKREEIREDRN-PRDGHDERKSKK-----RYRNEGSPSPRQSPKRR-REHS 845
+D+ RD ++E+ + +DR+ R+ +R+ +K R R G +Q + R RE
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQ 449
Query: 846 PDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRY 905
D A G + ++ R S + R RWK P K +S R+
Sbjct: 450 TDRQA---GRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDP--KAASTRF 504
Score = 212 bits (539), Expect = 3e-54
Identities = 133/378 (35%), Positives = 217/378 (57%), Gaps = 17/378 (4%)
Query: 604 ERDRYPERD-NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE- 661
E+DR+ +RD +R++ RD R ER+R+ +RERD++ + + R E ER+ RE
Sbjct: 84 EKDRHRKRDRHRERQRD-----REKERERQTDRERDRQRE---KERNRQKERERETEREG 135
Query: 662 ERRVDRVDDRRDERARERDRERERDRERERERER--ERDREREKERELERERARERERER 719
ER DR D + ER R+RD E+ER+R+ +RER+R ER+R++E+ERE R+ RERER+R
Sbjct: 136 ERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQR 195
Query: 720 EKERDRE-RDRDRDHDRERERERERDREKERERERE-ERERERERERERERERERERERA 777
EKE E R +R +RERERE E + E++R+ +RE +R+R+ ERERE++ ERER ER
Sbjct: 196 EKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERE 255
Query: 778 RERDKERERQRDWE-DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ 836
ERDKERER+RD + D+D+ + +R + + R+ R RD ERK +++ E +
Sbjct: 256 TERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNR 315
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKP 896
+R RE + + + EK R + + + R + E R+ +E +R+
Sbjct: 316 KRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERER 375
Query: 897 ERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDEN 956
ER S R E+E +E+ D+Q+E+ E R ++ + E S+R +
Sbjct: 376 ERDRQSAR--EREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG 433
Query: 957 KKKAKIQKKPIKKKKEDD 974
+++ K + + ++++ D
Sbjct: 434 REREKQKGRERDRERQTD 451
Score = 209 bits (532), Expect = 2e-53
Identities = 142/460 (30%), Positives = 241/460 (52%), Gaps = 42/460 (9%)
Query: 613 NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRR 672
+++ R + H + D D+RER+++ R + R E E D +RE RR DR
Sbjct: 33 SQESPRRRGLGQAHKDADG-DDRERNRQKERERRREKRQTERETDRKRERRREK---DRH 88
Query: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRD 732
+R R R+R+R+R++ERER+ +RERDR+REKER R++ERERE ER+ ER RDR
Sbjct: 89 RKRDRHRERQRDREKERERQTDRERDRQREKERN------RQKERERETEREGERGRDRQ 142
Query: 733 HDRERERERERDREKERERERE-ERERERERERERERERERERERARERDKERERQRDWE 791
D +RERER+RD EKERER+ + ER+R+ ER R++ERERE+ R+ RER+++RE++ E
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTE 202
Query: 792 DK--DKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ-SPKRRREHSPDS 848
D+ ++GR+ RE+ E +R + + + +K R + R+ + +R E +
Sbjct: 203 DRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER 262
Query: 849 DAYNSGD-DKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER-----KESS 902
+ D D++ + + + + R TE ++ R +E +R+ ER +E
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322
Query: 903 RRYEEQELKEKVSSVDKQRE-----QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENK 957
R E + +E +K+RE QTE ++ R R G Q+E +R D
Sbjct: 323 RERERERQRETERDREKERERKRKRQTE-MDRERNRQTGREGRRQAERERERERERDRQS 381
Query: 958 KKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIE--------KKRKK 1009
+ + ++ ++ ++ D ER DGQ + K+ +++K E ++R+K
Sbjct: 382 AREREER---ERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREK 438
Query: 1010 SKGDSDISDEEAAQQSKKKRGPRT-----PPITTKEELVE 1044
KG + + +Q+ ++R T PP T + +V+
Sbjct: 439 QKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQ 478
Score = 206 bits (523), Expect = 2e-52
Identities = 162/533 (30%), Positives = 251/533 (47%), Gaps = 63/533 (11%)
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERR--EDTRGKRDREKDSREEREYEQDQSSSRDHR 447
R+R RE+ R + +T + DR+ ERR +D KRDR ++ + +RE E+++ + R+
Sbjct: 56 RNRQKERER-RREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRER- 113
Query: 448 DDREPRDGRDRRDARDTRDRRELRDSRDMR-DSREMRDYSRDTKESRDPRDSRSTRDAHD 506
DR+ R+R+ R+ RE RD + D + R+ RD ++ R+ R T
Sbjct: 114 -DRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERE----RQTDRERQ 168
Query: 507 YRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGR 566
+ R R+ + +E R R RE+ ++TE R+ R R R R R
Sbjct: 169 RQTERNRQKEREREKNRQERRE--RERQREKENKTEDRHSERGRERERERETETETERKR 226
Query: 567 VPELPEKGSRGS-RGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER- 624
+ R + R + + ++ ++ + ERDR +RD R + R+ +R
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK 286
Query: 625 --RHGERDRRDNRERD-QRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERD 680
R ERDR R+R+ QR R + R E ER+ RE ER+ + DR ER R+R
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRK 346
Query: 681 RERERDRER------------ERERERERDRER-------EKERELERERAREREREREK 721
R+ E DRER ERERERER+R+R E+ER+ +R+R +ERER+ EK
Sbjct: 347 RQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEK 406
Query: 722 ERDRERDRDRDHDRERERERERDREKEREREREE-RERERERERERERERERERERARER 780
+RD +R+ ++ +RE++RE ER RE+ RERE+++ RER+RER+ +R+ R+R+R
Sbjct: 407 DRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVN 466
Query: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRD-----GHDERKSKKRYRNEGSPSPR 835
R + D R R + + ED G + S+ R PR
Sbjct: 467 PPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPR 526
Query: 836 QSPKRRR------------EHSPDSDA--------YNSGDDKNEKHRLLSQVV 868
KR + +P S A Y GD K H +LS V
Sbjct: 527 LGEKRGQGGEGRRPSGGFGTENPLSQAPSVFPGPRYTPGDGKRNVHTVLSVFV 579
Score = 191 bits (486), Expect = 4e-48
Identities = 116/405 (28%), Positives = 207/405 (51%), Gaps = 31/405 (7%)
Query: 644 PIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRER---ERERERERDRE 700
P+ R + RR D D+R R R +ERER RE+ ERE +R+R+R
Sbjct: 23 PLDFSRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERR 82
Query: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE------ 754
REK+R +R+R RER+R+REKER+R+ DR+RD RE+ER R+++RE+E ERE E
Sbjct: 83 REKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142
Query: 755 -ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNP 813
+ +RERER+R+ E+ERER+ +R R+R ER RQ++ +++K R +RRE+ + ++
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQKE-REREKNRQERRERERQREKENKT 201
Query: 814 RDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQES 873
D H ER ++ +R RE +++ D + ++ R + Q
Sbjct: 202 EDRHSERGRER--------------ERERETETETERKRQTDRERDRQRKTEREREKQAE 247
Query: 874 RSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMR 933
R + TE + R +E DR +R + E Q +++ ++ RE E R R
Sbjct: 248 RERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRER 307
Query: 934 AQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFS 993
++ + + E +R + ++ + ++K ++K++ ++R T +G+ +
Sbjct: 308 ERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQA 367
Query: 994 PKKGQKKK------SIEKKRKKSKGDSDISDEEAAQQSKKKRGPR 1032
++ ++++ + E++ ++ D D E Q K + G R
Sbjct: 368 ERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQR 412
Score = 107 bits (266), Expect = 1e-22
Identities = 86/336 (25%), Positives = 151/336 (44%), Gaps = 31/336 (9%)
Query: 1155 DSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSA 1214
D R+ R R + E T + Q + ++++ NR R R R +
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQER-----RERERQREKE 198
Query: 1215 HRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS 1274
+++ D S R R+RE+ + E ERK + D+ + + ++Q R +
Sbjct: 199 NKTEDRHSER-------GRERERERETETETERKRQTDRERDRQRKTEREREKQAERERA 251
Query: 1275 SRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN 1334
S R + E D++ R+R ++RDR R++ERER+ R+R+ + D++ R
Sbjct: 252 SERET-ERDKE----------RERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERK 300
Query: 1335 RDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR----- 1389
R+R R RERERER R + R+ +RERER ERDR+++R+R + +R
Sbjct: 301 RERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTG 360
Query: 1390 CEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLD 1449
E + + E ER+ E A ++E ++D + + + +TE G E++
Sbjct: 361 REGRRQAERERERERERDRQSAREREERERDRDRDR---QKERERQTEKDRDGQRETEKQ 417
Query: 1450 DAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQ 1485
+ G E + E + D E++ D+Q
Sbjct: 418 REREKDRESERGRERGREREKQKGRERDRERQTDRQ 453
Score = 101 bits (252), Expect = 5e-21
Identities = 122/576 (21%), Positives = 216/576 (37%), Gaps = 110/576 (19%)
Query: 75 RRSPERPTGDLRERM--KNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKE 132
+R ER T RER K++ + D +++ E + + R R REKE + KE
Sbjct: 68 KRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNR-QKE 126
Query: 133 RTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEII 192
R E+E E E RD +G + + E +RQ RE + + N +K E
Sbjct: 127 RERETEREG---ERGRDRQTDGQRERERQRDAEKERERQT-DRERQRQTERNRQKERERE 182
Query: 193 IKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSK 252
++ E R + K +K+ R S +++ +T D++R+ +
Sbjct: 183 KNRQERRERERQR-------EKENKTEDRHSERGRERERERETETETERKRQTDRERDRQ 235
Query: 253 TNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRD 312
+++ +K E+ + +R E+ ++ ++R RD +R R++R
Sbjct: 236 RKTERER------------------EKQAERERASERETERDKE-RERERDRDRDRDRRQ 276
Query: 313 KPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
K R +R + R++RT
Sbjct: 277 KER---------------------------ERQTDRKRQRRT------------------ 291
Query: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432
+R + R R RE+ R + +R+ ER + +R+R++++
Sbjct: 292 ----------ERDRETERKRERQRERERE------RERNRKRERERERERERERQRETER 335
Query: 433 EREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKES 492
+RE E+++ R DRE R R RE RD + +RE + RD
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERD---- 391
Query: 493 RDPRDSRSTRDAHDYRDREG-RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNES 551
RD RD + R+ +DR+G R+T ++ + + GR RE + + R
Sbjct: 392 RD-RDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE-----KQKGRERD 445
Query: 552 RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE--RDRYP 609
R + + GR R R R +R + S + W++ P+ R+P
Sbjct: 446 RERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFP 505
Query: 610 ERDNRDQARDSSFERRHGE---RDRRDNRERDQRPS 642
+R RR E ++R +RPS
Sbjct: 506 WGRPAKASRGRVAGRRRWEPRLGEKRGQGGEGRRPS 541
Score = 100 bits (250), Expect = 8e-21
Identities = 85/289 (29%), Positives = 128/289 (44%), Gaps = 29/289 (10%)
Query: 1142 TPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSH 1201
T T N R+ + R E+ E E + ++ + R S G R
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRER-----ERQREKENKTEDRHSERGRERERERE 217
Query: 1202 TSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSR 1261
T + R D + R+R R+REK E ER++ D+ + E R
Sbjct: 218 TE------TETERKRQTDRERDRQR---KTEREREKQAERERASERETERDKERERERDR 268
Query: 1262 STSSDRQ----DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRD 1317
DR+ + ++ R+ E DR+ + R+R +ER+R + +RERERER
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNR-KRERERERERER 327
Query: 1318 TRQREWDRDADKDWPRNRDRDRLRERERERE--RDKRRDLDRERER-------LISDSVE 1368
RQRE +RD +K+ R R R +RER R+ R+ RR +RERER + E
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Query: 1369 RDRDRDRDRTFE-SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER 1416
R+RDRDRDR E Q E + + + E + ER+ + S +ER
Sbjct: 388 RERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRER 436
Score = 93.2 bits (230), Expect = 2e-18
Identities = 74/255 (29%), Positives = 122/255 (47%), Gaps = 31/255 (12%)
Query: 1209 PSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQ 1268
P + S R G +S R+R L +D + G+ + R Q +R ++R+
Sbjct: 23 PLDFSRRRPGSQESPRRRGLGQAHKDAD--------GDDRERNRQKERERRREKRQTERE 74
Query: 1269 DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY---EHDRERERERRDTRQREWDR 1325
R RR E DR RDR +ER+R E DR+RE+ER RQ+E +R
Sbjct: 75 TDRKRERRR---EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKER--NRQKERER 129
Query: 1326 DADKDWPRNRDR----DRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFES 1381
+ +++ R RDR R RER+R+ E+++ R DRER+R + +++R+R+++R E
Sbjct: 130 ETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQ-ER 188
Query: 1382 SQIESVKRCEAKLEGEH---------ERDLESTSRDSLALDKERMDKDLGSVQGFEETNK 1432
+ E + E K E H ER+ E+ + D+ER D+ + + E+ +
Sbjct: 189 RERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER-DRQRKTEREREKQAE 247
Query: 1433 SERTESLEAGDDESK 1447
ER E D+ +
Sbjct: 248 RERASERETERDKER 262
Score = 91.3 bits (225), Expect = 7e-18
Identities = 69/252 (27%), Positives = 114/252 (45%), Gaps = 25/252 (9%)
Query: 1142 TPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSH 1201
T T T D RK R R ++ E + + + K +++R +R +
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKE- 278
Query: 1202 TSGRLRSPSNDSAHRSGDD-QSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS 1260
R R R+ D ++ RKR R RE+ + E +R+ ++ + E
Sbjct: 279 ---RERQTDRKRQRRTERDRETERKR-----ERQRERERERERNRKRERERERERERERQ 330
Query: 1261 RSTSSDRQDSRSHSSRRSSPESDRQVHSRSG------SFDSRDRLQERDRY--------E 1306
R T DR+ R +R + E DR+ + ++G + R+R +ERDR E
Sbjct: 331 RETERDREKERERKRKRQT-EMDRERNRQTGREGRRQAERERERERERDRQSAREREERE 389
Query: 1307 HDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDS 1366
DR+R+R++ RQ E DRD ++ + R+R++ RE ER RER + R+ + RER
Sbjct: 390 RDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRERQ 449
Query: 1367 VERDRDRDRDRT 1378
+R R R R+
Sbjct: 450 TDRQAGRQRKRS 461
Score = 90.9 bits (224), Expect = 9e-18
Identities = 90/391 (23%), Positives = 160/391 (40%), Gaps = 55/391 (14%)
Query: 1176 EDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR 1235
+++ R+ + Q + G +R R + + + R+ RDR
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 1236 EKTKSLEITGERKSRIDQ--------------------LKRGEPSRSTSSDRQDSRSHSS 1275
+ + + ER+ + D+ + GE R +D Q R
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERER-Q 152
Query: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDRYEH-----DRERERERRDT---------RQR 1321
R + E +RQ R+R +ER+R ++ +RER+RE+ + R+R
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212
Query: 1322 EWDRDADKDWPRNR--DRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTF 1379
E +R+ + + R R DR+R R+R+ ERER+K+ + +R ER ER+R+RDRDR
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 1380 ESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESL 1439
+ Q E ++ + K + ERD E+ + ++ER +++ + E + ER
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERER-ERERNRKRERERERERERERQR 331
Query: 1440 EAGDDESK-----------LDDAHSLGSGAGEG-----YEPISDDELDEILAGDAEKRED 1483
E D K +D + +G EG E + E D A + E+RE
Sbjct: 332 ETERDREKERERKRKRQTEMDRERNRQTGR-EGRRQAERERERERERDRQSAREREERER 390
Query: 1484 QQDEEKMPDPLDVIDVDWSGLMPKHPKEPRE 1514
+D ++ + + D G + RE
Sbjct: 391 DRDRDRQKERERQTEKDRDGQRETEKQRERE 421
Score = 89.7 bits (221), Expect = 2e-17
Identities = 79/276 (28%), Positives = 119/276 (43%), Gaps = 33/276 (11%)
Query: 1194 SNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT-KSLEITGERKSRID 1252
S R S S R R GDD+ ++ R++ +T + + ER+ D
Sbjct: 27 SRRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKD 86
Query: 1253 QLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQER------DRY- 1305
+ ++ + R DR+ R R++ E DRQ R+R ER DR
Sbjct: 87 RHRKRDRHRERQRDREKERE---RQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 1306 --EHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRE------RERERERDK------ 1351
+ +RER+R+ R+R+ DR+ + RNR ++R RE RERER+R+K
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTED 203
Query: 1352 ---RRDLDRERERLISDSVER----DRDRDRDRTFESSQIESVKRCEAKLEGEHERDLES 1404
R +RERER ER DR+RDR R E + + +R E E E ERD E
Sbjct: 204 RHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAER-ERASERETERDKER 262
Query: 1405 TSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
D++R K+ + ++ER E
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETE 298
Score = 86.7 bits (213), Expect = 2e-16
Identities = 98/442 (22%), Positives = 181/442 (40%), Gaps = 68/442 (15%)
Query: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR 120
H R + + + ER T R+R + K ++ E ++R TE +E RGR
Sbjct: 88 HRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKE-RERETE-------REGERGR 139
Query: 121 HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
R+ D + +ER ++E+E E +T+R+ + E RQK +RE K
Sbjct: 140 DRQ-TDGQRERERQRDAEKER-ERQTDRE------------RQRQTERNRQK-EREREKN 184
Query: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
QE E+ + R K + + R S + +R+ ++ + +++ R+T
Sbjct: 185 RQERRERERQ------------REKENKTED-RHSERGRERERERETETETERKRQTDR- 230
Query: 241 SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR 300
++ R KT + ++K E + KE+ + +DR ++ R K+R
Sbjct: 231 -----ERDRQRKTEREREKQAERERASERETE------RDKERERERDRDRDRDRRQKER 279
Query: 301 GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ 360
R +R+R++R + + + R + + +R R++ T +
Sbjct: 280 ERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET-----E 334
Query: 361 RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHER-RED 419
R R +RK+ R R+ GR + + +R ER R+
Sbjct: 335 RDREKERER-------------KRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381
Query: 420 TRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDS 479
R + +RE+D +R+ E+++ + +D RE R+R R++ RE R+ +
Sbjct: 382 AREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441
Query: 480 REMRDYSRDTKESRDPRDSRST 501
RE RD R T + RST
Sbjct: 442 RE-RDRERQTDRQAGRQRKRST 462
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 196 bits (498), Expect = 1e-49
Identities = 216/1039 (20%), Positives = 434/1039 (41%), Gaps = 124/1039 (11%)
Query: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEW- 144
RE+ + Q + E Q R ++ +R+E RH +K + + ++R +EE +W
Sbjct: 403 REQQLRREQQLRREQQLRREQQ----LRREQEEERHEQKHEQERREQRLKREQEERRDWL 458
Query: 145 ----ETNRDDSDNG--DINYDYVHE-------LSLEMKRQKIQRELMKLEQENMEKREEI 191
ET R + + + D E L E +R++ +R +L +E E+RE+
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 192 IIKKEVSPEVVRSKLSPSPSLRKSSKSPK----RKSSPKSSSASKKDRKTSAVSSPLLDQ 247
+ K++ E ++ +L LR+ + + ++ K +++++ DQ
Sbjct: 519 L-KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ 577
Query: 248 --QRNSKTNQSKKKGPRTPSPPPPIP----EDIALGKKYKEKYKVKDRIEEKTR-----D 296
+R + Q + K + + E + ++ +++ K ++ EE+ + +
Sbjct: 578 LLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSE 637
Query: 297 GKDRGRDFERQREKRDKPRSTSPAGQHHSPISSR----HHSSSSQSGSSIQRHSPSPRRK 352
++ R + +RE++++ + + R H + + + + R
Sbjct: 638 EQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERI 697
Query: 353 RTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDR 412
++ P +Q L A S S P++++ R + ++ R + E Q +R
Sbjct: 698 KSRIPKWQWQL----ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEER 753
Query: 413 RHERREDTRGKRD------------------------REKDSREEREYEQDQSSSRDHRD 448
H ++++ +RD RE+ R+ R E+ Q R +
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPE 813
Query: 449 DREPRDGRDRRDARDTR----------DRRE-----------LRDSRDMRDSREMRDYSR 487
+ E R +R R+ RRE L++ ++ R S+E R R
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR---R 870
Query: 488 DTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNES 547
D K + R R Y ++ RKE +E + RE+ R E +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930
Query: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607
R E + + +++ R E EK R R Q + + PE+ R
Sbjct: 931 REEEQLQQEEEQLLR------EEREKRRRQERERQYRKDKKLQQKEE--QLLGEEPEKRR 982
Query: 608 YPERDNRD------QARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE 661
ER+ + Q + R E+ RR ER R ++ + ++L R+ER +
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQE--EEQLLREEREK 1040
Query: 662 ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAR----ERER 717
R +R R+E +++ E+ ERE R +E +R+ KE EL++E + E E+
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 718 EREKERDRERDRDRDHDRERER----ERERDREKERERE-REERERERERERERERERER 772
R +ER+R+ + + +E E+ ERE+ R +E ER+ REE E ++E E+ E E+
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 773 ERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSP 832
R + ER E + E++ R+++ ++R+E + +K K+RYR+E
Sbjct: 1161 RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQR 1220
Query: 833 SPR--QSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWK 890
S Q + D+ Y G + + +L +R ++S+ HL ++Q R +
Sbjct: 1221 SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ-DLQHLLGEQQERDR 1279
Query: 891 EEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSD 950
E++R+ ++ EE++L+ + K+R++ E +R + + R+ +D
Sbjct: 1280 EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE----REEKRRRQETD 1335
Query: 951 RAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS 1010
R E ++ + +++ +++E D + E G+ F ++ Q+ + E++RK
Sbjct: 1336 RKFREEEQLLQEREEQPLRRQERDRKFREEELR-HQEQGRKFLEEE-QRLRRQERERKFL 1393
Query: 1011 KGDSDISDEEAAQQSKKKR 1029
K + + +E QQ ++ R
Sbjct: 1394 KEEQQLRCQEREQQLRQDR 1412
Score = 192 bits (487), Expect = 3e-48
Identities = 197/986 (19%), Positives = 419/986 (42%), Gaps = 105/986 (10%)
Query: 86 RERMKNKRQDVDTEP-----QKRNTEE------SSSPVRKESSRGRHREKEDIKITKERT 134
+ R + + + ++ EP QKR +E ++E R R++ D ++ ++R
Sbjct: 119 QRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQ 178
Query: 135 PESEEENVEWETNRDDSDNGDINYDYVHELSLEMKR-QKIQRELMKLEQENMEKREEIII 193
E E E + S G ++ E L + +++R+ + +Q+ +R++ +
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 194 KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKT 253
++E E + + LRK + + + + +++ + + L ++R +
Sbjct: 239 QEEEEKEWRKRE----TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEE 294
Query: 254 NQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDK 313
Q ++ + + +++ + EE+ R+ ++ R+ + +RE++++
Sbjct: 295 QQQ---------------------QRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 314 PRSTSPAGQHHSPISS--RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSA 371
R + R + ++R RR++ Q LRR
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 372 SPYPSHSLSSPQ--RKQSPPRHRSPMREKGRHDHERTSQSHDRRHER-REDTRGKRDRE- 427
L Q R++ R +R + + E+ + H+++HE+ R + R KR++E
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEE 453
Query: 428 -----KDSREEREYEQDQSSSRDHRDDREPRDGR----DRRDARDTRDRRELRDSRDMRD 478
K E +EQ++ + RD E R R + + R+ ++RRE + R+ +
Sbjct: 454 RRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
RE R ++ +E R + + +R + R+E+ E+ R R +E
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 539 SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
R ++ R E R R R+ R + E K R Q + + E
Sbjct: 574 RRDQLL--KREEER---RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRER-DQRPSSPIRHQGRNDELERD 657
R + E + Q R ERR R + ER +QR + R EL +
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 658 ERREER------------RVDRVDDRRDERARERDRERERDRERERERERERDREREKER 705
E+ + R +++ D R + R R++E R R+ + E+ R RE E +
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Query: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKERE-REREERERERERER 764
+ E ERA +++E E+ RD + ER R+R R RE RER+ R ER++
Sbjct: 749 Q-EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQRE 807
Query: 765 ERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNP-RDGHDERKSK 823
+R E E+E+ R + +ERE++ + ++++ + RRE+ ++++E+ + ++ + R+S+
Sbjct: 808 QRFLPEEEEKEQRRRQRREREKELQFLEEEE-QLQRRERAQQLQEEEDGLQEDQERRRSQ 866
Query: 824 KRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTE 883
++ R++ + ++RR H+ K L Q+ + Q+ L E
Sbjct: 867 EQRRDQKWRWQLEEERKRRRHT-----------LYAKPALQEQLRKEQQL-------LQE 908
Query: 884 DRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQS 943
+ + +EE K R+E R+Y E+E Q+E+ ++L R + + Q
Sbjct: 909 EEEELQREEREKRRRQEQERQYREEE--------QLQQEEEQLLREEREKRR-----RQE 955
Query: 944 EDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSI 1003
+R+ + K++ + ++P K+++++ R E E+ Q+ ++ ++++
Sbjct: 956 RERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Query: 1004 EKKRKKSKGDSDISDEEAAQQSKKKR 1029
+++ + K + +E+ ++ ++KR
Sbjct: 1016 WERQYRKKDELQQEEEQLLREEREKR 1041
Score = 187 bits (476), Expect = 5e-47
Identities = 198/1007 (19%), Positives = 411/1007 (40%), Gaps = 122/1007 (12%)
Query: 86 RERMKNK----RQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEEN 141
RER+K++ + +++E R ++ S P RK+ + R +E+E+ + +E + +EE
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRP-RKQEGQRRRQEQEEKRRRRESELQWQEEE 752
Query: 142 VEWETNRDDSDNGDINYDYVHELSLEMKRQKI--------QRELMKLEQENMEKREEIII 193
+++ D + + E E RQ++ QRE +E ++ + +
Sbjct: 753 RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLP 812
Query: 194 KKEVSPEVVRSKLSPSPSLR------KSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQ 247
++E + R + L+ + + + + + ++D++ DQ
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872
Query: 248 QRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQ 307
+ + + +K+ T P + E + KE+ +++ EE R+ +++ R E++
Sbjct: 873 KWRWQLEEERKRRRHTLYAKPALQEQLR-----KEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 308 REKRDKPRSTSPAGQ-----------HHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPS 356
R+ R++ + Q R Q + P RR++
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 357 PSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHER 416
Y+ L + K+ R+K E + R +R
Sbjct: 988 KKYRE------EEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 417 REDTRGKRDREKDSR---------EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDR 467
R R ++ RE++ EERE + Q R +R + E + ++ + R
Sbjct: 1042 RLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKR 1101
Query: 468 RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESR 527
R R R+ E++ + + R+ R+ R ++ E +E EE
Sbjct: 1102 RRQERERQCREEEELQQ--EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Query: 528 SYGRNHL-REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSH 586
R L R+ E++ E R E R R R E E+ R R +
Sbjct: 1160 KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE--EELQRQKRKQRYRDE 1217
Query: 587 SSNSNYHDSWETRSSYPERD-----RYPERDNRDQARDSSFERRH---------GERDRR 632
S+ WE RD + E + Q DS R GE+ R
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277
Query: 633 DNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERE 692
D + +R RH ++LER+E++E A+ RDR+ + +++ RE
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKE--------------AKRRDRKSQEEKQLLRE 1323
Query: 693 RERERDREREKERELERERAREREREREKERDRERDRD-RDHDRERERERERDREKERER 751
E+ R +E +R+ E +ERE + R +ERDR R+ + + + + E+E+
Sbjct: 1324 EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL 1383
Query: 752 EREERERERERERERERERERERERARERD---KERERQRDWEDKDKGRDDRREKREEIR 808
R+ERER+ +E ++ R +ERE++ ++RD +E E+Q +++D+ RE+ +++R
Sbjct: 1384 RRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDR---KFREEEQQVR 1440
Query: 809 EDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE---HSPDSDAYNSGDDKNEKHRLLS 865
R +E + ++ R+ Q + R E H + D +++ + +
Sbjct: 1441 RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500
Query: 866 QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRY--EEQELKEKVSSVDKQREQ 923
+ R QE RS P + ++ EE+++ R++ R++ EEQ+L+ + +++++
Sbjct: 1501 RKFREQELRSQEP-------ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDR 1553
Query: 924 -TEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNI 982
+ E ++R ++RE + E +K +++++ +++++++
Sbjct: 1554 DRKFREEEQLR----------QEREEQQLSRQERDRKFRLEEQKVRRQEQE--------- 1594
Query: 983 ETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKR 1029
ED Q ++GQ++ E+ RK + + + + E Q +++R
Sbjct: 1595 RKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Score = 186 bits (471), Expect = 2e-46
Identities = 195/1007 (19%), Positives = 426/1007 (42%), Gaps = 99/1007 (9%)
Query: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWE 145
R+ ++ +RQ+ + + Q+ E+ +R++ R ++E+ + +ER + EE +
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQ---LRRKQEEERREQQEERREQQERREQQEERREQ-- 337
Query: 146 TNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSK 205
+++R++ +R +L +E E+R E +++E E +
Sbjct: 338 ---------------------QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 206 LSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPS 265
L LR+ + + + + ++ + Q R + + +++ R
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Query: 266 PPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325
+ L ++ +E+ R EE R ++R +Q+ KRD+
Sbjct: 437 KHEQERREQRLKREQEERRDWLKREEETERHEQER----RKQQLKRDQEEERRERWLKLE 492
Query: 326 PISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRK 385
R + ++R R +R + L LR S +R+
Sbjct: 493 EEERREQQERREQ--QLRREQEERREQRLKRQEEEERLQQRLR---------SEQQLRRE 541
Query: 386 QSPPRHRSPMREKGRH-DHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSR 444
Q R + RE+ + + ER Q R E R D KR+ E+ + + ++++ R
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR 601
Query: 445 DHRDDREPRDGRDRRDARDTRD-----RRELRDSRDMRDSREMRDYSRDTKESRDPRDSR 499
R++ E + +RR+ R R+ RR+ + ++ R + R+ +E R+ R R
Sbjct: 602 LKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKR 661
Query: 500 STRDAH-DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND 558
+ + R + + R+E EE + R ++ + + + ES ++R
Sbjct: 662 EEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYS 721
Query: 559 RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQAR 618
R + G+ ++ R R S++ W+ E + ++ +Q R
Sbjct: 722 RPRKQEGQRRRQEQEEKRRRRESELQ-----------WQE-----EERAHRQQQEEEQRR 765
Query: 619 DSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER--REERRVDRVDDRRDERA 676
D +++ + E+ R + RP P+R Q R +L +ER RE+R + +++ R
Sbjct: 766 DFTWQWQAEEKSERGRQRLSARP--PLREQ-RERQLRAEERQQREQRFLPEEEEKEQRRR 822
Query: 677 RERDRERERDRERERERERERDRERE-KERELERERAREREREREKERDRERDRDRDHDR 735
+ R+RE+E E E+ + R+R ++ +E E + +ER R +E+ RD++ + +R
Sbjct: 823 QRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEER 882
Query: 736 ERER---------------ERERDREKEREREREERERERERERERERERERERERARER 780
+R R E++ +E+E E +REERE+ R +E+ER+ E + ++ E+
Sbjct: 883 KRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQ 942
Query: 781 --DKERERQRDWEDKDKGRDDRR--EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ 836
+ERE++R E + + R D++ +K E++ + + ER+ K R E Q
Sbjct: 943 LLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQ 1002
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQ-ESRSLSPSH--LTEDRQGRWKEED 893
+ RE + K+E + Q++R + E R L E+ + + +EE
Sbjct: 1003 LLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQ 1062
Query: 894 RKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
E +E+ RR E + K + ++ EQ E + R Q+ +R+ +
Sbjct: 1063 LLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQE-------RERQCREEEE 1115
Query: 954 DENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD 1013
+ +++ ++++ K+++++ R E E+ Q+ + ++++ +++ + + +
Sbjct: 1116 LQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEE 1175
Query: 1014 SDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKE 1060
+E+ ++ ++KR +EE ++ K ++ Q+ +
Sbjct: 1176 LQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSD 1222
Score = 184 bits (467), Expect = 6e-46
Identities = 204/1000 (20%), Positives = 424/1000 (42%), Gaps = 89/1000 (8%)
Query: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHRE----KEDIKITKERTPESEEEN 141
RE ++ +R+ + + Q+R + +E R RE KE+ K+ +E P+ + E
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEE-PQRQREL 271
Query: 142 VEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEV 201
E E + ++ + E + + ++ Q+ K E+E E++EE ++E
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE----- 326
Query: 202 VRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGP 261
R+ + +R+ + +++++ L +Q + Q ++
Sbjct: 327 -----------RREQQEERREQQLRREQEERREQQ-------LRREQEEERREQQLRREQ 368
Query: 262 RTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAG 321
+ + L ++ + + + + R E++ R + R+ + +RE++ +
Sbjct: 369 EEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 322 QHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSS 381
Q +H + QR +R + T R L
Sbjct: 429 QEEERHEQKHEQERRE-----QRLKREQEERRDWLKREEET-----ERHEQERRKQQLKR 478
Query: 382 PQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDS-----REEREY 436
Q ++ R E+ R ER Q R E R + R KR E++ R E++
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 437 EQDQSSSRDH--RDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRD 494
++Q R+ + + E R ++RR+ R R++ E RD R+ E R R +E +
Sbjct: 539 RREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE--EERRQQRLKREQEE 596
Query: 495 PRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
+ R R+ + ++E R R + PEE R R L + + E R + + E
Sbjct: 597 RLEQRLKREEVERLEQEERREQRLKREEPEEER---RQQLLKSEEQEERRQQQLRREQQE 653
Query: 555 IRNDRMGR--SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERD 612
R R+ R R+ + ++ R Q + + ++R + E D
Sbjct: 654 RREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 613 NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRV---- 668
R S ++ G+R R++ E+ +R S ++ Q + R ++ EE+R D
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQ-EEERAHRQQQEEEQRRDFTWQWQ 772
Query: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
+ + ER R+R R RE+ + R +R++ ++R L E +E+ R + +ER++E
Sbjct: 773 AEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERER------ERERERER------ 776
+ ++ + RER + ++E + +E++ER R +E+ R++ E ER+R R
Sbjct: 833 FLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAK 892
Query: 777 -ARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPR 835
A + +E+Q E++++ + + REKR ++R R+ ++ +++ E R
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE-EREKR 951
Query: 836 QSPKRRREHSPDSDAYNSGD----DKNEKHRLLSQVVRPQESRSLSPSH---LTEDRQGR 888
+ +R R++ D + ++ EK R + + +E L L E+R+ R
Sbjct: 952 RRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKR 1011
Query: 889 WKEEDRKPERKESSRRYEEQEL----KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSE 944
++E + RK+ + EE++L +EK +++R+ E E + + ++G E
Sbjct: 1012 RRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYRE-EEELQQEEEQLLG----E 1066
Query: 945 DRETSDRAHDEN--KKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKS 1002
+RET R E +K+ ++Q++ + +E+ R E + + ++ Q +
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 1003 IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEEL 1042
+KR++ + + +EE QQ +++ P ++EL
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQEL 1166
Score = 184 bits (466), Expect = 8e-46
Identities = 213/1080 (19%), Positives = 459/1080 (42%), Gaps = 101/1080 (9%)
Query: 75 RRSPERPTGDLRERMKNK-RQDVDTEPQKRNT---EESSSPVRKESSRGRHREKEDIKIT 130
R+ E RER +++ + E +KR T +E +E R R ++E+ ++
Sbjct: 220 RKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLR 279
Query: 131 K----ERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQE--- 183
K E E +EE + + R + + E E + Q+ +RE + +E
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQL 339
Query: 184 --NMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVS 241
E+R E +++E E +L + + +R+ + +++++
Sbjct: 340 RREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQ 399
Query: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVK--DRIEEKTRDGKD 299
+QQ + +++ R E+ +K++++ + + R +E+ RD
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 300 RGRDFERQREKRDKPRSTSPAGQHHSP-----ISSRHHSSSSQSGSSIQRHSPSPRRKRT 354
R + ER ++R K + + + ++R R +R
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 355 PSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMR-EKGRHDHERTSQSHDRR 413
+ L LR S +R+Q R + R E+ R + ER Q R
Sbjct: 520 KRQEEEERLQQRLR---------SEQQLRREQEERREQLLKREEEKRLEQERREQRLKRE 570
Query: 414 HERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTR-----DRR 468
E R D KR+ E+ + + ++++ R R++ E + +RR+ R R +RR
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH-DYRDREGRDTHRKEDTYPEESR 527
+ + ++ R + R+ +E R+ R R + + R + + R+E EE +
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 528 SYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHS 587
R ++ + + + ES ++R R + G+ ++ R R S++
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL---- 746
Query: 588 SNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRH 647
W+ E + ++ +Q RD +++ + E+ R + RP P+R
Sbjct: 747 -------QWQ-----EEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARP--PLRE 792
Query: 648 QGRNDELERDER--REERRVDRVDDRRDERARERDRERERDRERERERERERDRERE-KE 704
Q R +L +ER RE+R + +++ R + R+RE+E E E+ + R+R ++ +E
Sbjct: 793 Q-RERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851
Query: 705 RELERERAREREREREKERDRERDRDRDHDRERER---------------ERERDREKER 749
E + +ER R +E+ RD++ + +R+R R E++ +E+E
Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911
Query: 750 EREREERERERERERERE-RERER-----------ERERARERDKERERQRDWEDKDK-- 795
E +REERE+ R +E+ER+ RE E+ ERE+ R +++ER+ ++D + + K
Sbjct: 912 ELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEE 971
Query: 796 ---GRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR--RREHSPDSDA 850
G + + +R+E RE + + +++ ++ R E RQ +R R++ +
Sbjct: 972 QLLGEEPEKRRRQE-REKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 851 YNSGDDKNEKHRLLSQVVRPQESRSLSPSH---LTEDRQGRWKEE-DRKPERKESSRRYE 906
++ EK RL + + +E L L E+R+ R ++E +R+ ++E ++ E
Sbjct: 1031 EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEE 1090
Query: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKP 966
EQ L+E+ +Q + + E ++ ++ + ++ + +++ ++Q++
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEE 1150
Query: 967 IKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSK 1026
+ +E+ R +E + + ++ Q + ++KR++ + + +EE Q+ K
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER-ERQYREEEELQRQK 1209
Query: 1027 KKRGPRTPPITTKEELVEMCNGKNGILEDS---QKKEDTAFSDWSDEDVPDRTEVTEAEH 1083
+K+ R + + +N + ++ + +E+ F D + DR + +H
Sbjct: 1210 RKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQH 1269
Score = 177 bits (448), Expect = 9e-44
Identities = 164/684 (23%), Positives = 297/684 (43%), Gaps = 65/684 (9%)
Query: 397 EKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREE---REYEQDQSSSRDHRDDREPR 453
EK + S DRR E ED R R++ EE R ++ Q R+ + E
Sbjct: 98 EKRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 454 DGRDRRDARDTRDR-RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREG 512
+ ++R + RD + R EL R RE R + +S ++ D R RE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRREL 215
Query: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572
+ RK ++ R ++ + +E E R + E + R R + E
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 573 KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRR 632
+ R ++ R R + ER + + R ERR + +RR
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 633 D---NRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRER 689
+ RE+++R +R + + E+ RRE+ R R E+ R+++ R+++
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 690 ERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKER 749
RE++ R+++ +E++L RE+ RE++ +E++ ER H+++ E+ER RE+
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER-----HEQKHEQER---REQRL 447
Query: 750 EREREERERERERERERERERERERERARERDKERERQRDW----EDKDKGRDDRRE--- 802
+RE+EER +RE E ER + R++ +RD+E ER+ W E++ + + +RRE
Sbjct: 448 KREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQL 507
Query: 803 --KREEIREDRNPRDGHDER-----KSKKRYRNEGSPSPRQSPKR---------RREHSP 846
++EE RE R R +ER +S+++ R E Q KR RRE
Sbjct: 508 RREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRL 567
Query: 847 DSDAYNSGDD--KNEKHRLLSQVVRPQESR--------SLSPSHLTEDRQGRWKEEDRKP 896
+ D K E+ R ++ R QE R + E R+ R K E+ +
Sbjct: 568 KREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEE 627
Query: 897 ERKESSRRYEEQELKEKVS---SVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
ER++ + EEQE + + ++REQ E R + + E+R + A
Sbjct: 628 ERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 954 DENKK-----KAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRK 1008
+E ++ K++I K + + E D + ++GQ ++++ E+KR+
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ-------RRRQEQEEKRR 740
Query: 1009 KSKGDSDISDEEAAQQSKKKRGPR 1032
+ + + +EE A + +++ R
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQR 764
Score = 176 bits (447), Expect = 1e-43
Identities = 173/801 (21%), Positives = 331/801 (41%), Gaps = 65/801 (8%)
Query: 281 KEKYKVKDRIEEKTRDGKDRGRDFE-----RQREKRDKPRSTSPAGQHHSPISSRHHSSS 335
KE R EE R + R R E R+R+KR + G+ S R
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 336 SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPM 395
Q +R R+++ +R +S + + P +Q R +
Sbjct: 166 RQ-----RRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF--PDEEQLRRRELLEL 218
Query: 396 REKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE--YEQDQSSSRDHRDDREPR 453
R KGR + ++ + R + E+ + R RE R+E E E++ R+ +++ E
Sbjct: 219 RRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL 278
Query: 454 DGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGR 513
+R++ R R E + R R+ + R + +E ++ R + ++R +
Sbjct: 279 RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER--------REQQERREQ 330
Query: 514 DTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEK 573
R+E E LR E + R E E R ++ R + E +
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 574 GSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRD 633
+ R Q + R R++ R+ Q R E RH ++ ++
Sbjct: 391 REQQLRREQ-------QLRREQQLRREQQLRREQQLRRE--QQLRREQEEERHEQKHEQE 441
Query: 634 NRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERER 693
RE+ + R E E + +ERR ++ ++E RER + E + RE++
Sbjct: 442 RREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQE 501
Query: 694 ERERDREREKERELERERAREREREREKERDR-ERDRDRDHDRERERERERDREKERERE 752
RE+ RE+E E+ R+ E ER ++R R E+ R+ + RE+ +R+ EK E+E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 753 REERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRN 812
R E+ +RE+E R++ +RE ER ++R K RE++ E + K + R ++EE RE R
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLK-REQEERLEQRLKREEVERLEQEERREQRL 620
Query: 813 PRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQE 872
R+ +E + ++ ++E RQ RR + + E+ L Q ++ +
Sbjct: 621 KREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK----REEEEERLEQRLKREH 676
Query: 873 SRSLSPSHLTEDRQGRWKE--EDRKPE---RKESSRRYEEQELKEKVSSVDKQREQTEIL 927
L E+ Q + +E + R P+ + ES + ++ + + QR + E
Sbjct: 677 EEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQE 736
Query: 928 ESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSE 987
E R R ++ Q E+R + +E ++ Q + +K ERG ++
Sbjct: 737 EKRRRRESEL--QWQEEERAHRQQQEEEQRRDFTWQWQAEEKS-------ERGRQRLSAR 787
Query: 988 DGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPR---------TPPITT 1038
P + Q+++ + + ++ + + +EE +Q +++R R +
Sbjct: 788 -----PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 1039 KEELVEMCNGKNGILEDSQKK 1059
+E ++ ++G+ ED +++
Sbjct: 843 RERAQQLQEEEDGLQEDQERR 863
Score = 173 bits (439), Expect = 1e-42
Identities = 199/977 (20%), Positives = 411/977 (42%), Gaps = 119/977 (12%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
R E+ RER K + + + ++ EE R+E + ++RE+E+++ +E+
Sbjct: 945 REEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK-KYREEEELQQEEEQL 1003
Query: 135 PESEEEN---VEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ-RELMKLEQENMEKREE 190
E E EWE D ++ + L E +++++Q RE E+E +++ EE
Sbjct: 1004 LREEREKRRRQEWERQYRKKD--ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEE 1061
Query: 191 III--------KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSS 242
++ ++E+ + + + + + P+++ + +++ +
Sbjct: 1062 QLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEE 1121
Query: 243 PLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIA-----------LGKKYKEKYKVKDRIE 291
LL ++R + Q ++ R E + L ++Y+E+ +++ E
Sbjct: 1122 QLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEE 1181
Query: 292 EKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRR 351
+ R+ +++ R ER+R+ R++ R+ +S Q
Sbjct: 1182 QLLREEQEKRRQ-ERERQYREEEEL------QRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 352 KRT--------PSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRH-- 401
R + +++ LR S L Q+++ + R +++ RH
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFP 1294
Query: 402 ---DHERTSQSHDRRHER---------REDTRGKRDREKDSREEREYEQDQSSSRDHRDD 449
ER Q +R +R RE+ KR R++ R+ RE EQ +
Sbjct: 1295 EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLR 1354
Query: 450 REPRDGRDRRDA------------RDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRD 497
R+ RD + R + + R RR+ R+ + +++ +++R R+ ++ R RD
Sbjct: 1355 RQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQERE-QQLRQDRD 1413
Query: 498 SRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNES------ 551
R R+ R+ RD +E+ + R L EE + R+ E
Sbjct: 1414 -RKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Query: 552 RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPE- 610
R E + R R R + E Q+ + + + E RS PER E
Sbjct: 1473 REEQQLHRQERDRKFLEE----------EQQLRRQERDRKFREQ-ELRSQEPERKFLEEE 1521
Query: 611 -------RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
R + + R+ + RR +R+R R +R + +L R ER +
Sbjct: 1522 QQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF 1581
Query: 664 RVDRVDDRRDERARE--RDRERERDRERERERERERDREREKERELERERAREREREREK 721
R++ RR E+ R+ D ++ R +E +++ +ERDR+ ++ +L +ER ++ +E+
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 722 ERD--RERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE 779
+R E + R +RE++ +RDR K RE E+ +E E ++ R +ER+R+ E +
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDR-KFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 780 RDKERERQRDWEDKDKGRDDRREK---REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ 836
R +ERER+ E++ R + K E++R++ + + +K E R+
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSL-SPSHLTEDRQGRWKEEDR- 894
+ RR+ D K + L Q Q+ RS S E+ Q R + E++
Sbjct: 1761 EQQLRRQER---------DRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 895 -KPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
+P++++ R+EE++L+ +++Q ++ + RA++ + RE +
Sbjct: 1812 LRPQQRDGKYRWEEEQLQ-----LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQ 1866
Query: 954 DENKKKAKIQKKPIKKK 970
+E +K+ + +++ ++++
Sbjct: 1867 EEEQKRRQERERKLREE 1883
Score = 172 bits (435), Expect = 3e-42
Identities = 204/1042 (19%), Positives = 437/1042 (41%), Gaps = 115/1042 (11%)
Query: 87 ERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEE-NVEWE 145
E+ + +RQ + E + + EE R+E ++ E++ ++ +ER E+ + +W
Sbjct: 816 EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWR 875
Query: 146 TNRDDSDNGDINYDYVH---ELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVV 202
++ + Y + L ++Q +Q E +L++E EKR +++ E
Sbjct: 876 WQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE- 934
Query: 203 RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPR 262
+ + LR+ + +R+ + +KD+K LL ++ + Q ++K R
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQY---RKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 263 TPSPPPPIPEDIALGKKYKEK-------YKVKDRIEEKT----RDGKDRGRDFERQREKR 311
E + ++ K + Y+ KD ++++ R+ +++ R ER+R+ R
Sbjct: 992 EEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR 1051
Query: 312 DKPRSTSPAGQ-----------HHSPISSRHHSSSSQSGSSIQRHSPSPRRKRT------ 354
++ Q R Q + R P RR++
Sbjct: 1052 EEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCR 1111
Query: 355 PSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSP------------PRHRSPMREKGRHD 402
Q+ LR L R++ P R + ++
Sbjct: 1112 EEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR 1171
Query: 403 HERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDR--------EP-- 452
E Q + + R E + +++RE+ REE E ++ + R +D+ EP
Sbjct: 1172 EEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEK 1231
Query: 453 ----RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR 508
RD + R+ R+L DS+ +RD + +D E ++ RD R R
Sbjct: 1232 ENAVRDNKVYCKGRENEQFRQLEDSQ-LRDRQSQQDLQHLLGEQQE-RDREQERRRWQQR 1289
Query: 509 DREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIR---NDRMGRSRG 565
DR + + E +E++ R E+ E R E R ++ + +++ + R
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 566 RVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRY----------PERDNR- 614
P ++ R R ++ + + E R ER+R ER+ +
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQLRCQEREQQL 1408
Query: 615 DQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE---RREERRVDR---- 667
Q RD F + R++ + + +R Q R + +E R+E R R
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468
Query: 668 -VDDRRDERARERDRERERDRERERERERERDRE--------REKERELERERARERERE 718
+ +R +++ ++R+R+ E ++ R +ERDR+ +E ER+ E + ++
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 719 REKERDRERDRDRDHDRERERERERDRE-KEREREREERERERERERERERERERERERA 777
R+++ +E + R +R ++R ++RDR+ +E E+ R+ERE ++ +ER+R+ E ++
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588
Query: 778 RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPS-PRQ 836
R +++ER+ D + + ++ ++E R+ R ER+ ++ +R E +
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEE 1648
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKP 896
P+ RR+ + D++ K R Q+++ E + L ++R +++EE+++
Sbjct: 1649 EPQLRRQEREQQLRH----DRDRKFREEEQLLQEGEEQQLR----RQERDRKFREEEQQL 1700
Query: 897 ERKESSRRY-------EEQELKEKVSSVDKQREQTEILESSRM-RAQDIIGHHQ-SEDRE 947
R+E R++ QEL+ K ++ R++TE + R R + I+ Q +RE
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760
Query: 948 TSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKR 1007
E +K + +++ +++++E+ + + E+ Q+ ++ Q+ + ++
Sbjct: 1761 EQQLRRQERDRKFR-EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 1008 KKSKGDSDISDEEAAQQSKKKR 1029
K + + EE Q+ +++R
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQER 1841
Score = 166 bits (420), Expect = 2e-40
Identities = 169/828 (20%), Positives = 344/828 (41%), Gaps = 43/828 (5%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
R PE+ RER + +++ E ++ EE R+E R ++RE+E+++ +E+
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER-QYREEEEVQQEEEQL 1153
Query: 135 PESE-EENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIII 193
E E+ E R + ++ + L E ++++ +RE E+E +++++
Sbjct: 1154 LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR--- 1210
Query: 194 KKEVSPEVVRSKLSPSPSLRKSS---------KSPKRKSSPKSSSASKKDRKTSAVSSPL 244
K+ E RS L K + K + + + + +DR++ L
Sbjct: 1211 KQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHL 1270
Query: 245 LDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDF 304
L +Q+ Q +++ + PE+ L ++ +++ K +DR ++ + R+
Sbjct: 1271 LGEQQERDREQERRRWQQRDRH---FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327
Query: 305 ERQREKRDKP-RSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTL 363
+R+R++ D+ R Q R + RH R+ +R
Sbjct: 1328 KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387
Query: 364 TPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK 423
R L +R+Q + R R+ + + + Q DR+ E +
Sbjct: 1388 ----RERKFLKEEQQLRCQEREQQLRQDRD--RKFREEEQQLSRQERDRKFREEEQQVRR 1441
Query: 424 RDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMR 483
++RE+ EE + + + + +++ ++ +++ R RDR+ L + + +R R
Sbjct: 1442 QERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Query: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE- 542
+ S++P + +R + R ++E + R R R+ R E
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 543 -IRNESRNESRSEIRNDRMGR---------SRGRVPELPEKGSRGSRGSQIDSHSSNSNY 592
+R E + S DR R + R E+ R G Q + +
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF 1621
Query: 593 HDSWETRSSYPERDRY-PERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRN 651
+ + E+ + ERD + + R+ E+ R +R+R R + +G
Sbjct: 1622 REDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 652 DELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERER 711
+L R ER + R + RR ER R+ +E ++ R +E ER+ + + +E E E+ R
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLR 1741
Query: 712 AREREREREKERDRERDRDRDHDRERERERERDREKEREREREE---RERERERERERER 768
+ER R+ +E +R+ R +ER+R+ E++ +EREE R +E +R+ E
Sbjct: 1742 RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEE 1801
Query: 769 ERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRN 828
+ +ERE + R ++R+ + WE++ +++ ++ + R DR R +K R
Sbjct: 1802 QLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQER-DRQYRAEEQFATQEKSRRE 1860
Query: 829 EGSPSPRQSPKRR--REHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR 874
E + KRR RE + + ++HR + + ++ QE +
Sbjct: 1861 EQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE-IKSQEGK 1907
Score = 126 bits (316), Expect = 2e-28
Identities = 106/466 (22%), Positives = 222/466 (47%), Gaps = 43/466 (9%)
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVD 669
E+ R ++S + R E D+R RD++ G+ +R E+ E
Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEE---EPGQRRRQKRQEQERELAEGEEQ 154
Query: 670 DRRDERARERDRERERDRERERERE--RERDREREKEREL--------------ERERAR 713
+ ER +RDR+R RD E R+R+ +ER+ R +E +L E+ R R
Sbjct: 155 SEKQERLEQRDRQR-RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 714 E-----REREREKERDRERDRDRDHDRERERE-RERD---REKEREREREERERERERER 764
E R+ EK++ R +DR E E+E R+R+ R++E + + EE +R+RE +
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 765 ERERERERERERARERDKERERQ-----RDWEDKDKGRDDRREKREEIREDRNPRDGHDE 819
E E+ R+ ER+ R +E E+Q R+ + + K ++RRE++EE RE + R+ +E
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 820 RKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPS 879
R+ ++ R + +Q + + E + +++ + +L + +E +
Sbjct: 334 RREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQ 393
Query: 880 HLTEDRQGRWKEEDRKPE--RKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDI 937
L ++Q R +++ R+ + R+E R E+Q +E+ +Q+ + E E R Q+
Sbjct: 394 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE- 452
Query: 938 IGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSE--DGQVFSPK 995
RE H++ ++K ++++ ++++E + +E E + Q+ +
Sbjct: 453 -ERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 996 KGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEE 1041
+ ++++ ++++ ++ + + E QQ ++++ R + +EE
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSE---QQLRREQEERREQLLKREE 554
Score = 107 bits (268), Expect = 7e-23
Identities = 92/417 (22%), Positives = 196/417 (47%), Gaps = 55/417 (13%)
Query: 658 ERREERRVDRVDDRRDERARERDRERERDRERERERE---RERDREREKERELERERARE 714
+ + R D + +R +E D+ R R+R+ E E R R + +E+EREL +
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 715 REREREKERDRERDRDRDHDRERERERERDREKERERER---------------EERERE 759
++ER ++RDR+R RD + R+R+ ++RE+ R E EE+ R
Sbjct: 156 EKQERLEQRDRQR---RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRR 212
Query: 760 RERERERERERERERERARERDK---ERERQRDW--------EDKDKGRDDRREKREEIR 808
RE R + RE ++++ RER + E +++W ++++K +++ +++ E++
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 809 EDRNP----------RDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKN 858
E+ R+ +E + ++R R E +Q +RR + + + +
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332
Query: 859 EKH----RLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE--RKESSRRYEEQELKE 912
E+ R + R Q+ R E + R +EE+R+ + R+E R E+Q +E
Sbjct: 333 ERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRRE 392
Query: 913 KVSSVDKQ-REQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKK 971
+ ++Q R + ++ ++R + + Q RE + H E K + + +++ +K+++
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERH-EQKHEQERREQRLKREQ 451
Query: 972 EDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKK 1028
E+ + ET + + +K Q K+ E++R++ + +EE +Q +++
Sbjct: 452 EERRDWLKREEETERHEQE---RRKQQLKRDQEEERRERW--LKLEEEERREQQERR 503
Score = 104 bits (259), Expect = 8e-22
Identities = 96/422 (22%), Positives = 201/422 (47%), Gaps = 23/422 (5%)
Query: 673 DERARERDRERE---RDRERERERERERDREREKEREL-ERERAREREREREKERDRERD 728
DE R R +E +DR +E ++ R R+R+ E E +R R + +E+ERE E+
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQR 788
++ +R+R+R RD E R+R+ E +ERE R E + + + E D+E+ R+R
Sbjct: 156 EKQERLEQRDRQR-RDEELWRQRQ-EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 789 D-WEDKDKGRDDRREKREEIREDR--NPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHS 845
+ E + KGR++++++R E R+DR + + RK + R E + P+R+RE
Sbjct: 214 ELLELRRKGREEKQQQRRE-RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 846 PDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRY 905
+ + K E+ L R ++ L ++Q R K+E+ + E++E R
Sbjct: 273 EEEEQLR----KLERQELR----RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324
Query: 906 EE-QELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQK 964
+E +E +E+ +REQ E E R Q+ Q RE + ++ ++ + +
Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384
Query: 965 KPIKKKKEDDVGIER--GNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAA 1022
+ + ++E + E+ + + Q+ ++ ++++ + +++++ + + E
Sbjct: 385 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444
Query: 1023 QQSKKKRGPRTPPITTKEELV--EMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE 1080
Q+ K+++ R + +EE E K + D +++ + +E+ ++ E E
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERRE 504
Query: 1081 AE 1082
+
Sbjct: 505 QQ 506
Score = 66.2 bits (160), Expect = 2e-10
Identities = 83/361 (22%), Positives = 150/361 (41%), Gaps = 28/361 (7%)
Query: 1161 HRTRVEKVETPHVTIEDAQHRKPMDQK---RSSSLGSNRSNRSHTSGRLRSPSNDSAHRS 1217
HR E+ + E HR+ D+K L +R LRS +
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 1218 GDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS-RSTSSDRQDSRSHSSR 1276
+ Q R++ ++ ++ + E +R+ D+ R E R ++Q SR R
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579
Query: 1277 RSSPESD---RQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPR 1333
+ E RQ R D + ++ + + +ER+R+ R+ Q +R+ + +
Sbjct: 1580 KFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQ 1639
Query: 1334 NRDRDRLRE----RERERERDKRRDLD---RERERLISDSVERD-RDRDRDRTF--ESSQ 1383
RDR L E R +ERE+ R D D RE E+L+ + E+ R ++RDR F E Q
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 1384 IESVKRCEAKLEGEHE---RDLESTSRDSLALDKERMDKDLGSVQGF-----EETNKSER 1435
+ +R L+ E + ++LE R+ L +E + L + + EE + ER
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 1436 TE-SLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPL 1494
E L + + K + L E + + E D + + R+++++++ P
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREE--QQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 1495 D 1495
D
Sbjct: 1818 D 1818
Score = 63.5 bits (153), Expect = 1e-09
Identities = 72/362 (19%), Positives = 152/362 (41%), Gaps = 36/362 (9%)
Query: 1159 KCHRTRVEKVETPHVTIE-DAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRS 1217
+ HR + E+ + T + A+ + ++R S+ R R +LR+ +
Sbjct: 753 RAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRER---QLRAEERQQREQR 809
Query: 1218 GDDQSGRKRVLHSGSRDREKTKSL---EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS 1274
+ K R+REK E +R+ R QL+ E +R+ RS
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR--RSQE 867
Query: 1275 SRRSSP---ESDRQVHSRSGSFDSRDRLQERDRYEHD-----------RERERERRDTRQ 1320
RR + + + R + ++ LQE+ R E ERE+ RR ++
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 1321 REWDRDA----DKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRD 1376
R++ + +++ +R++ R +ERER+ K + L ++ E+L+ + E+ R ++R+
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQERE 987
Query: 1377 RTFE-----SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETN 1431
+ + + E + R E + E + + +D L ++E++ ++ + +E
Sbjct: 988 KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Query: 1432 KSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDEL----DEILAGDAEKREDQQDE 1487
+ R E ++E L + + ++EL +++L + EKR Q+ E
Sbjct: 1048 RQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 1488 EK 1489
+
Sbjct: 1108 RQ 1109
Score = 61.6 bits (148), Expect = 6e-09
Identities = 61/290 (21%), Positives = 128/290 (44%), Gaps = 18/290 (6%)
Query: 1166 EKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225
E+ E E + R+ +++R L + R R + +Q +
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQ-LKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
R R+++ + ++ E++ R +Q L+R + R R++ + ++ E +
Sbjct: 373 REQQL-RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431
Query: 1285 QVHSRSGSFDSRDRLQERD---------RYEHDRERERERRDTR-QREWDRDADKDWPRN 1334
+ H + + R++ +R+ R E E+ERR + +R+ + + + W +
Sbjct: 432 ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 1335 RDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKL 1394
+ +R RE++ RE+ RR+ + RE+ + E +R + R R+ + + E +R E L
Sbjct: 492 EEEER-REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLL 550
Query: 1395 EGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETN----KSERTESLE 1440
+ E E+ LE R+ L +E+ ++ ++ EE K E+ E LE
Sbjct: 551 KREEEKRLEQERREQ-RLKREQEERRDQLLKREEERRQQRLKREQEERLE 599
Score = 58.2 bits (139), Expect = 6e-08
Identities = 60/277 (21%), Positives = 118/277 (42%), Gaps = 26/277 (9%)
Query: 1177 DAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDRE 1236
+ Q R+ +R L + R R + + R H R +
Sbjct: 386 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQ 445
Query: 1237 KTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSR 1296
+ K E++ R D LKR E T Q+ R +R E R+ + + R
Sbjct: 446 RLKR-----EQEERRDWLKREE---ETERHEQERRKQQLKRDQEEERRERWLKLEEEERR 497
Query: 1297 DRLQERDRY-EHDRERERERRDTRQREWDRDADK---DWPRNRDRDRLRERERERERDKR 1352
++ + R++ ++E RE+R RQ E +R + + R+++ RE+ +RE +KR
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Query: 1353 RDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLAL 1412
+ +R +RL +R+++ RD+ + + +R + +L+ E E LE +
Sbjct: 558 LEQERREQRL-----KREQEERRDQLLKREE----ERRQQRLKREQEERLEQRLKRE--- 605
Query: 1413 DKERMDKDLGSVQGF--EETNKSERTESLEAGDDESK 1447
+ ER++++ Q EE + R + L++ + E +
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Score = 57.8 bits (138), Expect = 8e-08
Identities = 63/317 (19%), Positives = 125/317 (39%), Gaps = 52/317 (16%)
Query: 1177 DAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDD--QSGRKRVLHSGSRD 1234
+ + R+ KR + R R + D + ++ Q KR
Sbjct: 541 EQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 1235 REKTKSLEITGERKSRIDQLKRGEPSRST------SSDRQDSRSHSSRRSSPESDRQVHS 1288
R K + +E + + R +LKR EP S ++++ R RR E Q
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 1289 RSGSFDSRDRLQERDRYEHDRER------ERERRDTRQR--------EWDRDADKDWPRN 1334
R + +RL++R + EH+ ER E E+ R+R +W +++ D ++
Sbjct: 661 RE---EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQS 717
Query: 1335 RDRDRLRERERERERDKRRDLDRERERLI-------SDSVERDRDRDRDRTFESSQIESV 1387
+ R R++E +R R ++ + R RE + + +++ ++ RD T++ E
Sbjct: 718 KVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS 777
Query: 1388 KRCEAKLEG------EHERDL--------------ESTSRDSLALDKERMDKDLGSVQGF 1427
+R +L + ER L E ++ + +K+L ++
Sbjct: 778 ERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE 837
Query: 1428 EETNKSERTESLEAGDD 1444
E+ + ER + L+ +D
Sbjct: 838 EQLQRRERAQQLQEEED 854
Score = 57.8 bits (138), Expect = 8e-08
Identities = 54/254 (21%), Positives = 107/254 (42%), Gaps = 13/254 (5%)
Query: 1206 LRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSS 1265
LR + R D+ R+ R+ + + E +RK R ++L+ E R
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE--RDRKFREEELRHQEQGRKFLE 1378
Query: 1266 DRQDSRSHSSRRSSPESDRQVHSRSGSFD---SRDRL-----QERDRYEHDRERERERRD 1317
+ Q R R + ++Q+ + RDR Q+ R E DR+ E +
Sbjct: 1379 EEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQ 1438
Query: 1318 TRQREWDR---DADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374
R++E +R + ++ + R R E + +ER++++ +ER+R + ++ R ++
Sbjct: 1439 VRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE 1498
Query: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
RDR F ++ S + LE E + + R L +++ ++ G + + K
Sbjct: 1499 RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR 1558
Query: 1435 RTESLEAGDDESKL 1448
E L +E +L
Sbjct: 1559 EEEQLRQEREEQQL 1572
Score = 57.0 bits (136), Expect = 1e-07
Identities = 65/302 (21%), Positives = 129/302 (42%), Gaps = 21/302 (6%)
Query: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDS 1213
E R+ + R E+ + Q + +QK R R R +
Sbjct: 404 EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEE 463
Query: 1214 AHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSH 1273
R +Q RK+ L + + + L++ E + R Q +R + R +R++ R
Sbjct: 464 TERH--EQERRKQQLKRDQEEERRERWLKLEEEER-REQQERREQQLRREQEERREQRL- 519
Query: 1274 SSRRSSPESDRQVHSRSGSFDSRDRLQERDRY---EHDRERERERRDTRQREWDRDADKD 1330
+R E Q RS R++ + R++ E ++ E+ERR+ R + ++
Sbjct: 520 --KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK-------RE 570
Query: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVER-DRDRDRDRTFESSQIESVKR 1389
RD+ RE ER ++R KR +R +RL + VER +++ R++ + + E +R
Sbjct: 571 QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Query: 1390 CE-AKLEGEHERDLESTSRDSLALDKERM---DKDLGSVQGFEETNKSERTESLEAGDDE 1445
+ K E + ER + R+ ++R+ +++ Q + ++ ER E A +++
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 1446 SK 1447
+
Sbjct: 691 EQ 692
Score = 56.6 bits (135), Expect = 2e-07
Identities = 70/346 (20%), Positives = 141/346 (40%), Gaps = 26/346 (7%)
Query: 1164 RVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSG 1223
++E+ E E+ Q ++ + +++ R R + R +
Sbjct: 280 KLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER-----REQQERREQQEER 334
Query: 1224 RKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESD 1283
R++ L +R + + L E + R QL+R + ++Q R RR
Sbjct: 335 REQQLRREQEERRE-QQLRREQEEERREQQLRREQEEERR--EQQLRREQQLRREQQLRR 391
Query: 1284 RQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRER 1343
Q R +L+ + +++ RE++ R++E +R K R++ RE+
Sbjct: 392 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ 451
Query: 1344 ERER------ERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGE 1397
E R E +R + +R +++L D E R+R + E + E +R E +L E
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL-KLEEEERREQQERREQQLRRE 510
Query: 1398 HERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSG 1457
E E R ++ER+ + L S Q + ER E L ++E +L+
Sbjct: 511 QEERRE--QRLKRQEEEERLQQRLRSEQQLRR-EQEERREQLLKREEEKRLEQER----- 562
Query: 1458 AGEGYEPISDDELDEILAGDAEKRED---QQDEEKMPDPLDVIDVD 1500
+ + ++ D++L + E+R+ ++ EE++ L +V+
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Score = 55.5 bits (132), Expect = 4e-07
Identities = 56/280 (20%), Positives = 116/280 (41%), Gaps = 23/280 (8%)
Query: 1175 IEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRD 1234
+ED+Q R Q+ L + R R R D H ++Q R+ + RD
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDR-HFPEEEQLEREEQKEAKRRD 1311
Query: 1235 REKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFD 1294
R+ + ++ E +R E R +DR+ + E + R F
Sbjct: 1312 RKSQEEKQLLRE--------EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFR 1363
Query: 1295 SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRD 1354
+ + + E +R RR R+R++ ++ + + R++ ++R+R+ ++++
Sbjct: 1364 EEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQL 1423
Query: 1355 LDRERERLISDSVERDRDRDRDRTF--ESSQI-----ESVKRCEAKLEGEHERDLESTSR 1407
+ER+R + ++ R ++R+R F E Q+ + E L+ E+ L R
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 1408 DSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESK 1447
D L++E+ + +E ++ R + L + + E K
Sbjct: 1484 DRKFLEEEQQLRR-------QERDRKFREQELRSQEPERK 1516
Score = 54.3 bits (129), Expect = 9e-07
Identities = 68/321 (21%), Positives = 128/321 (39%), Gaps = 18/321 (5%)
Query: 1185 DQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKR--VLHSGS---RDREKTK 1239
+Q R L R + R D + +++ RKR VL ++ E +
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 1240 SLEITGERKSRIDQLKRGEPSRSTSSDRQDS----RSHSSRRSSPESDR-QVHSRSGSFD 1294
E+ E + ++ +L+R E R + Q R RR E R Q R +
Sbjct: 268 QRELQ-EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 1295 SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRD 1354
R++ +ER + RE+E R +RE + + + R + RE++ RE+ RR+
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE 386
Query: 1355 LDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKL-----EGEHERDLESTSRDS 1409
RE+ + + R++ R + + + ++R E +L E HE+ E R+
Sbjct: 387 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-EQQLRREQEEERHEQKHEQERREQ 445
Query: 1410 -LALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDD 1468
L ++E L + E + R + L+ +E + + L + +
Sbjct: 446 RLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQ 505
Query: 1469 ELDEILAGDAEKREDQQDEEK 1489
+L E+R +Q+EE+
Sbjct: 506 QLRREQEERREQRLKRQEEEE 526
Score = 53.5 bits (127), Expect = 2e-06
Identities = 51/225 (22%), Positives = 95/225 (42%), Gaps = 21/225 (9%)
Query: 1236 EKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSP--ESDRQVHSRSGSF 1293
++ K G+ D+ + + R DRQ RR E +R++
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQS 155
Query: 1294 DSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN---------RDRDRLRERE 1344
+ ++RL++RDR D E R+R++ ++RE +R A+++ ++ D ++LR RE
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQERE-ERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 1345 ----RERERDKRRDLDRERERLISDSVERDRDRDRDRTFES-----SQIESVKRCEAKLE 1395
R + R++++ RER+ + E R R+ + E ++ E + E
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 1396 GEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
E R LE ++E+ + L Q + ER E E
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Score = 53.5 bits (127), Expect = 2e-06
Identities = 59/334 (17%), Positives = 135/334 (40%), Gaps = 38/334 (11%)
Query: 1182 KPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSL 1241
K + QK LG R R + +R ++ + L R++ + +
Sbjct: 964 KKLQQKEEQLLGEEPEKR-------RRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 1242 EITGERKSRI----DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRD 1297
E +K + +QL R E + +R+ R + + + Q+ R
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERE--RQYREEEELQQEEEQLLGEERETRRRQ 1074
Query: 1298 RLQERDRYEHDRERERE----------RRDTRQR----EWDRDADKDWPRNRDRDRLRER 1343
L+ + R E + ++E E RR R+R E + +++ +R++ R +
Sbjct: 1075 ELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQ 1134
Query: 1344 ERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLE 1403
E ER+ + ++ +E E+L+ + E+ R ++ +R + E +++ E +L E E++
Sbjct: 1135 ELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE--EELQQEEEQLLRE-EQEKR 1191
Query: 1404 STSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYE 1463
R+ ++E + + + +E +S+ E + + D+ E +
Sbjct: 1192 RQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR 1251
Query: 1464 PISDDELD--------EILAGDAEKREDQQDEEK 1489
+ D +L + L G+ ++R+ +Q+ +
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRR 1285
Score = 53.5 bits (127), Expect = 2e-06
Identities = 56/233 (24%), Positives = 102/233 (43%), Gaps = 15/233 (6%)
Query: 1233 RDREKTKSLEITGERKSRID--QLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQV-HSR 1289
R +E+ + L +RK R + QL R E R + Q R R E ++Q+ R
Sbjct: 1400 RCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQER 1459
Query: 1290 SGSFDSRDR-LQERD-----RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDR--LR 1341
F ++ LQER+ R E DR+ E + R++E DR + R+++ +R L
Sbjct: 1460 HRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 1342 ERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
E ++ + ++R +E ++L + R +DRDR F + +R E +L ERD
Sbjct: 1520 EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQL-SRQERD 1578
Query: 1402 LESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSL 1454
+ + R +++ ++ ++ + E + L D +D L
Sbjct: 1579 RKFRLEEQKV---RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLL 1628
Score = 53.1 bits (126), Expect = 2e-06
Identities = 72/363 (19%), Positives = 137/363 (37%), Gaps = 50/363 (13%)
Query: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDS 1213
E R+ R + E+ E +E R+ +++R L ++ + R P
Sbjct: 650 EQQERREQRLKREEEEE---RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW 706
Query: 1214 AHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSH 1273
S D R+ ++S R +E + R+ + ++ +R E + + R
Sbjct: 707 QLESEAD--ARQSKVYSRPRKQEGQR------RRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 1274 SSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERE---RERRDTRQREWDRDADKD 1330
+ Q + S R RL R RER+ ER+ QR + +K+
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 1331 WPRNRDRDR------------LRERER-----------ERERDKRRDLDRERERLISDSV 1367
R + R+R L+ RER + ++++RR ++ R++ +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 1368 ERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDS-LALDKERMDKDLGSVQG 1426
E +R R R + ++ R E +L E E +L+ R+ ++ER ++ +Q
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQ 938
Query: 1427 FEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQD 1486
EE E E + E + L + +++L + EKR Q+
Sbjct: 939 EEEQLLREEREKRRRQERERQYRKDKKL------------QQKEEQLLGEEPEKRRRQER 986
Query: 1487 EEK 1489
E+K
Sbjct: 987 EKK 989
Score = 49.7 bits (117), Expect = 2e-05
Identities = 55/247 (22%), Positives = 101/247 (40%), Gaps = 47/247 (19%)
Query: 1234 DREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESD--RQVHSRSG 1291
+REK + E+ ER+ R ++ + E + + + R R E + +Q +
Sbjct: 1127 EREKRRRQEL--ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLL 1184
Query: 1292 SFDSRDRLQERDR-YEHDRERERERRDTRQREWDRDADKDWP------------------ 1332
+ R QER+R Y + E +R++R R R+ D+ +D W
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKG 1244
Query: 1333 ------RNRDRDRLRER--------------ERERERDKRRDLDRERERLISDSVERDRD 1372
R + +LR+R ER+RE+++RR R+R + +ER+
Sbjct: 1245 RENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 1373 RDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNK 1432
++ R SQ E E + E ++ + R+ L +ER ++ L +E ++
Sbjct: 1305 KEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR----QERDR 1360
Query: 1433 SERTESL 1439
R E L
Sbjct: 1361 KFREEEL 1367
Score = 49.7 bits (117), Expect = 2e-05
Identities = 64/363 (17%), Positives = 145/363 (39%), Gaps = 28/363 (7%)
Query: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDS 1213
++ RK + E +E+ Q + +++R + +LR D
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ-DRDR 1414
Query: 1214 AHRSGDDQSGRKRVLHSGSRDREKTKSLE-----ITGERKSRIDQLKRGEPSRSTSSDRQ 1268
R + Q R+ + ++ + E + E++ R ++ ++ +R+
Sbjct: 1415 KFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQERE 1474
Query: 1269 DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDAD 1328
+ + H R + + R D + R QE E +R+ E + +++ R
Sbjct: 1475 EQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 1329 KDWPRNRDRDRLRERERERERDKRRD--LDRERERLISDSVERDRD----------RDRD 1376
++ + R ++R ++R ++R+R R + L +ERE ERDR ++++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQE 1594
Query: 1377 RTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKE-----RMDKDLGSVQGFEETN 1431
R F + + ++R E + + ERD + + L ++E R ++D ++ +
Sbjct: 1595 RKFMEDE-QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Query: 1432 KSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDD----ELDEILAGDAEKREDQQDE 1487
+ ER + L D ++ L G + D E ++ L +R+ Q+E
Sbjct: 1654 RQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEE 1713
Query: 1488 EKM 1490
+++
Sbjct: 1714 QQL 1716
Score = 48.9 bits (115), Expect = 4e-05
Identities = 50/233 (21%), Positives = 101/233 (43%), Gaps = 21/233 (9%)
Query: 1221 QSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSP 1280
Q +++ H R + + L GE + QL+R E R + Q R R
Sbjct: 1655 QEREQQLRHDRDRKFREEEQLLQEGEEQ----QLRRQERDRKFREEEQQLRRQERERKFL 1710
Query: 1281 ESDRQVHSRS--GSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRD 1338
+ ++Q+ + F ++L++ E R +ER R+ + + + ++ R ++RD
Sbjct: 1711 QEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERD 1770
Query: 1339 R-LRERERER-ERDKRRDLDRERERLISDSVE----------RDRDRDRDRTFESSQIES 1386
R RE E+ R ER++++ +E +R + + R + RD +E Q++
Sbjct: 1771 RKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQ- 1829
Query: 1387 VKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESL 1439
++ E +L E +R + + + R +++L Q E+ + ER L
Sbjct: 1830 LEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELW--QEEEQKRRQERERKL 1880
Score = 40.0 bits (92), Expect = 0.018
Identities = 45/206 (21%), Positives = 84/206 (40%), Gaps = 12/206 (5%)
Query: 1205 RLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS---- 1260
+LR D R + Q R+ ++ ++ + E+ ERK R ++ R E
Sbjct: 1683 QLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL--ERKFREEEQLRQETEQEQL 1740
Query: 1261 RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRL-QERDRYE-HDRERERERRDT 1318
R R+ R E + R F ++L QER+ + +E +R+ R+
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREE 1800
Query: 1319 RQREWDRDADKDWPRNRDRDRLRERER----ERERDKRRDLDRERERLISDSVERDRDRD 1374
Q +R+ + P+ RD E E+ E+E+ R++ DR+ + + R+
Sbjct: 1801 EQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRRE 1860
Query: 1375 RDRTFESSQIESVKRCEAKLEGEHER 1400
++ + + + E KL EH R
Sbjct: 1861 EQELWQEEEQKRRQERERKLREEHIR 1886
Score = 37.4 bits (85), Expect = 0.11
Identities = 39/198 (19%), Positives = 83/198 (41%), Gaps = 12/198 (6%)
Query: 1219 DDQSGRKRVLHSGSRD----REKTKSLEITG-ERKSRIDQLKRGEPSRSTSSDRQDSRSH 1273
++Q R++ L R+ R++T+ ++ ER +I + ++ P R R+ R
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDR 1771
Query: 1274 SSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERER---ERRDTRQREWDRDADKD 1330
R + + S +S + +E ++ +RE ++ ++RD + R + +
Sbjct: 1772 KFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLE 1831
Query: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390
R R + R E+ ++ R E+ + E+ R ++R+R I R
Sbjct: 1832 EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHI----RR 1887
Query: 1391 EAKLEGEHERDLESTSRD 1408
+ K E H + E S++
Sbjct: 1888 QQKEEQRHRQVGEIKSQE 1905
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 195 bits (496), Expect = 3e-49
Identities = 111/227 (48%), Positives = 152/227 (66%), Gaps = 21/227 (9%)
Query: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642
++S + + H ET ER R +R+ RD+A++S E RH ERDR+ +RER
Sbjct: 1 MESKTEGRHTHTETETMDRQRERRRETDRE-RDRAKESKTEDRHSERDRQRDRER----- 54
Query: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERER----D 698
N E +RD RE ++ DR +R+ ER R+RDR+RE +RER++ERE +R D
Sbjct: 55 --------NRERDRDRERE-KQTDREGERQRERERDRDRQRETERERDKERETDRHTETD 105
Query: 699 REREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERER 758
RER+K++E E ER R+RERE++KE RER DR+ DRERER+ ER+RE RER+ E+R R
Sbjct: 106 RERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHR 165
Query: 759 ERERERERERERERE-RERARERDKERERQRDWEDK-DKGRDDRREK 803
ERERER+RERER+RE +ER R D ERERQR+ + K D+ R+ RE+
Sbjct: 166 ERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERER 212
Score = 166 bits (419), Expect = 2e-40
Identities = 77/194 (39%), Positives = 130/194 (67%), Gaps = 1/194 (0%)
Query: 650 RNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELER 709
R E D R+ + + +DR ER R+RDRER R+R+R+RERE++ DRE E++RE ER
Sbjct: 21 RERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERER 80
Query: 710 ERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERE 769
+R R+RE ERE++++RE DR + DRER++++ER+ E+ R+RER E+++E RER+ +RE
Sbjct: 81 DRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRER-EKQKEMGRERQTDRE 139
Query: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
+RERER ER++E R+R ED+ + R+ R++ E + + R+ H + + +++ +
Sbjct: 140 TDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETD 199
Query: 830 GSPSPRQSPKRRRE 843
++ +R R+
Sbjct: 200 RKRDRQRESERERD 213
Score = 162 bits (409), Expect = 3e-39
Identities = 87/207 (42%), Positives = 136/207 (65%), Gaps = 8/207 (3%)
Query: 648 QGRNDELERDERREERRVDRVDDRRDERARE---RDRERERDRERERERERERDREREKE 704
+GR+ E + +R R DR +RA+E DR ERDR+R+RER RERDR+RE+E
Sbjct: 6 EGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65
Query: 705 RELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE-ERERERERE 763
++ +RE R+RERER+++R RE +R+RD +RE +R E DRE+++++ERE ER R+RERE
Sbjct: 66 KQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE 125
Query: 764 RERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSK 823
+++E RER+ + RE D+ERERQ + +++ GR+ + E R RE R+ +R++K
Sbjct: 126 KQKEMGRERQTD--RETDRERERQAE-RERETGRERKTEDRHRERERERKRERERKRETK 182
Query: 824 KRYRNEGSPSPRQ-SPKRRREHSPDSD 849
+R R+ RQ R+R+ +S+
Sbjct: 183 ERERHTDMERERQRETDRKRDRQRESE 209
Score = 155 bits (391), Expect = 4e-37
Identities = 82/209 (39%), Positives = 130/209 (62%), Gaps = 8/209 (3%)
Query: 656 RDERREERRVDRVDDRRDERARERDRERERDRERERE-RERERDREREKERELERERARE 714
+ E R DR+ ER RE DRER+R +E + E R ERDR+R++ER ER+R RE
Sbjct: 4 KTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRE 63
Query: 715 REREREKERDRERDRDRDHDRERERERERDREKERERERE-ERERERERERERERERERE 773
RE++ ++E +R+R+R+RD DR+RE ERERD+E+E +R E +RER++++ERE ER R+RE
Sbjct: 64 REKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE 123
Query: 774 RERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPS 833
RE+ +E +ER+ R + D+ R+ + E+ E +R D H ER+ +++ E
Sbjct: 124 REKQKEMGRERQTDR---ETDRERERQAERERETGRERKTEDRHRERERERKRERE---R 177
Query: 834 PRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
R++ +R R + + D K ++ R
Sbjct: 178 KRETKERERHTDMERERQRETDRKRDRQR 206
Score = 136 bits (343), Expect = 1e-31
Identities = 83/219 (37%), Positives = 129/219 (58%), Gaps = 26/219 (11%)
Query: 686 DRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDR 745
DR+RER RE +R+R+R KE + E +R ER+R+R++ER+RERDRDR ERE++ DR
Sbjct: 18 DRQRERRRETDRERDRAKESKTE-DRHSERDRQRDRERNRERDRDR------EREKQTDR 70
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE 805
E ER+RER ER+R+R+RE ERER++ERE +R E D+ER++Q++ + ++ RD REK++
Sbjct: 71 EGERQRER-ERDRDRQRETERERDKERETDRHTETDRERQKQKE-REMERVRDREREKQK 128
Query: 806 EIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLS 865
E+ +R D + ++ R + R++ R RE + K E+ R
Sbjct: 129 EMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERER--------KRERERKRE 180
Query: 866 QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRR 904
R + T+ + R +E DRK +R+ S R
Sbjct: 181 TKERERH---------TDMERERQRETDRKRDRQRESER 210
Score = 131 bits (330), Expect = 4e-30
Identities = 91/228 (39%), Positives = 127/228 (55%), Gaps = 30/228 (13%)
Query: 546 ESRNESR-SEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
ES+ E R + + M R R R E + R D HS D
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRD---------- 51
Query: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERD-----QRPSSPIRHQGRNDELERD-E 658
R+R ERD RD+ R+ +R GER R R+RD +R R R+ E +R+ +
Sbjct: 52 RERNRERD-RDREREKQTDRE-GERQRERERDRDRQRETERERDKERETDRHTETDRERQ 109
Query: 659 RREERRVDRVDDRRDE------RARERDRERERDRERERERERERDREREKERELERERA 712
+++ER ++RV DR E R R+ DRE +R+RER+ ERERE RER+ E +R R
Sbjct: 110 KQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTE---DRHRE 166
Query: 713 REREREREKERDRE-RDRDRDHDRERERERERDREKEREREREERERE 759
RERER+RE+ER RE ++R+R D ERER+RE DR+++R+RE ERER+
Sbjct: 167 RERERKRERERKRETKERERHTDMERERQRETDRKRDRQRE-SERERD 213
Score = 110 bits (275), Expect = 1e-23
Identities = 71/213 (33%), Positives = 105/213 (49%), Gaps = 11/213 (5%)
Query: 714 EREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERE 773
E + E DR +R RE +RERDR KE + E ER+R+R+RER RER+R+
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRD 61
Query: 774 RERARERDKERERQRDWE-DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSP 832
RER ++ D+E ERQR+ E D+D+ R+ RE+ +E DR+ + +K K+R
Sbjct: 62 REREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRD 121
Query: 833 SPRQSPKRR-REHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKE 891
R+ K RE D + + + E+ R R H +R+ R +E
Sbjct: 122 REREKQKEMGRERQTDRETDRERERQAERER------ETGRERKTEDRHRERERE-RKRE 174
Query: 892 EDRKPERKESSRR--YEEQELKEKVSSVDKQRE 922
+RK E KE R E + +E D+QRE
Sbjct: 175 RERKRETKERERHTDMERERQRETDRKRDRQRE 207
Score = 88.6 bits (218), Expect = 4e-17
Identities = 82/301 (27%), Positives = 123/301 (40%), Gaps = 91/301 (30%)
Query: 396 REKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDG 455
+ +GRH H T ++ DR+ ERR +T +RDR K+S+
Sbjct: 4 KTEGRHTHTET-ETMDRQRERRRETDRERDRAKESK------------------------ 38
Query: 456 RDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDT 515
T DR RD + R+ RD R+ +E + R+ R+ RDR+ R+T
Sbjct: 39 --------TEDRHSERDRQRDRERNRERDRDRE-REKQTDREGERQRERERDRDRQ-RET 88
Query: 516 HRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGS 575
R+ D E R + R++ E+ R R + MGR R
Sbjct: 89 ERERDKERETDRHTETDRERQKQKEREM---ERVRDREREKQKEMGRER----------- 134
Query: 576 RGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNR 635
Q D R + ER+R ER+ R+ R+ E RH ER+R R
Sbjct: 135 ------QTD--------------RETDRERERQAERE-RETGRERKTEDRHRERERERKR 173
Query: 636 ERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERER 695
ER+++ R+ + ER D ER R+R+ +R+RDR+RE ERER
Sbjct: 174 ERERK---------------RETKERERHTDM------ERERQRETDRKRDRQRESERER 212
Query: 696 E 696
+
Sbjct: 213 D 213
Score = 87.0 bits (214), Expect = 1e-16
Identities = 58/226 (25%), Positives = 103/226 (45%), Gaps = 42/226 (18%)
Query: 734 DRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWE-D 792
DR+RER RE DRE++R +E + +R ER+R+R+RER RER+R RER+K+ +R+ + + +
Sbjct: 18 DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRE 77
Query: 793 KDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYN 852
+++ RD +RE E R+ D H E R R+ + +
Sbjct: 78 RERDRDRQRETERE-RDKERETDRHTETD------------------RERQKQKEREMER 118
Query: 853 SGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKE 912
D + EK + GR ++ DR+ +R+ + E+E
Sbjct: 119 VRDREREKQK----------------------EMGRERQTDRETDRERERQAERERETGR 156
Query: 913 KVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKK 958
+ + D+ RE+ + R R ++ + D E + + K+
Sbjct: 157 ERKTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKR 202
Score = 85.1 bits (209), Expect = 5e-16
Identities = 59/189 (31%), Positives = 97/189 (51%), Gaps = 13/189 (6%)
Query: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS-RDRLQERDRY-EHDRERERERRDTRQ 1320
T ++ D + R + E DR S++ S RDR ++R+R E DR+RERE++ R+
Sbjct: 12 TETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDRE 71
Query: 1321 REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE 1380
E R+ ++D R+R R+ RER++ERE D+ + DRER++ +ER RDR+R++ E
Sbjct: 72 GERQRERERD--RDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKE 129
Query: 1381 SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
+ E + + E +R+ E + +ER +D + E K ER E
Sbjct: 130 MGR-------ERQTDRETDRERERQAERERETGRERKTEDRHRER--ERERKRERERKRE 180
Query: 1441 AGDDESKLD 1449
+ E D
Sbjct: 181 TKERERHTD 189
Score = 82.4 bits (202), Expect = 3e-15
Identities = 58/195 (29%), Positives = 97/195 (49%), Gaps = 16/195 (8%)
Query: 1231 GSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS---SRRSSPESDRQVH 1287
G +T++++ ER+ D+ +R S + DR R R + DR+
Sbjct: 7 GRHTHTETETMDRQRERRRETDR-ERDRAKESKTEDRHSERDRQRDRERNRERDRDRERE 65
Query: 1288 SRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERER 1347
++ R R +ERDR DR+RE ER ++RE DR + D R + ++R ER R+R
Sbjct: 66 KQTDREGERQRERERDR---DRQRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122
Query: 1348 ERDKRRDL------DRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
ER+K++++ DRE +R ER+R+ R+R E E + E K E E +R+
Sbjct: 123 EREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRE--RERERKRERERKRE 180
Query: 1402 LESTSRDSLALDKER 1416
+ R + +++ER
Sbjct: 181 TKERERHT-DMERER 194
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/207 (28%), Positives = 100/207 (48%), Gaps = 23/207 (11%)
Query: 1219 DDQSGRKRVLHSGSRDREKTKSLEI-TGERKSRIDQLKRGEPSRSTSSDRQ-----DSRS 1272
D Q R+R DRE+ ++ E T +R S D+ + E +R DR+ D
Sbjct: 18 DRQRERRR-----ETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREG 72
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY---EHDRERERERRDTRQREWDRDADK 1329
R + DRQ + RD+ +E DR+ + +R++++ER R R+ +R+ K
Sbjct: 73 ERQRERERDRDRQRETER----ERDKERETDRHTETDRERQKQKEREMERVRDREREKQK 128
Query: 1330 DWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
+ R R DR +RERER+ ++ R+ RER+ + +R R+R+R+R E + K
Sbjct: 129 EMGRERQTDRETDRERERQAERERETGRERK-----TEDRHRERERERKRERERKRETKE 183
Query: 1390 CEAKLEGEHERDLESTSRDSLALDKER 1416
E + E ER E+ + + ER
Sbjct: 184 RERHTDMERERQRETDRKRDRQRESER 210
Score = 77.0 bits (188), Expect = 1e-13
Identities = 58/178 (32%), Positives = 90/178 (50%), Gaps = 20/178 (11%)
Query: 1279 SPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRD 1338
S R H+ + ++ DR +ER R E DRER+R + + DR +++D R RDR+
Sbjct: 3 SKTEGRHTHTET---ETMDRQRERRR-ETDRERDRAKESKTE---DRHSERD--RQRDRE 53
Query: 1339 RLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
R RER+R+RER+K+ D + ER+R ER+RDRDR R E + + + + E +
Sbjct: 54 RNRERDRDREREKQTDREGERQR------ERERDRDRQRETERER-DKERETDRHTETDR 106
Query: 1399 ERDLESTSRDSLALDKER-MDKDLGSVQGFEETNKSERTESLEAGDD---ESKLDDAH 1452
ER + D+ER K++G + + ER E + E K +D H
Sbjct: 107 ERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRH 164
Score = 68.6 bits (166), Expect = 5e-11
Identities = 66/268 (24%), Positives = 122/268 (45%), Gaps = 68/268 (25%)
Query: 745 REKEREREREERERERERERERERERERERERARERDKERERQRDWE-DKDKGRDDRREK 803
R E E +R+RER RE +RER+R +E + +R ER+RQRD E ++++ RD REK
Sbjct: 8 RHTHTETETMDRQRERRRETDRERDRAKE-SKTEDRHSERDRQRDRERNRERDRDREREK 66
Query: 804 REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRL 863
+ + R+G +R+RE D D + + +K R
Sbjct: 67 QTD-------REG----------------------ERQRERERDRDRQRETERERDKERE 97
Query: 864 LSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQEL---KEKVSSVDKQ 920
+ H DR+ R K+++R+ ER R +++E+ ++ D++
Sbjct: 98 TDR-------------HTETDRE-RQKQKEREMERVRDREREKQKEMGRERQTDRETDRE 143
Query: 921 REQTEILESSRMRAQDIIGHHQSEDRETSDRAHD-ENKKKAKIQKKPIKKKKEDDVGIER 979
RE+ ++ R R +R+T DR + E ++K + ++K K++E +ER
Sbjct: 144 RER----QAERER-------ETGRERKTEDRHRERERERKRERERKRETKERERHTDMER 192
Query: 980 GNIETTSEDGQVFSPKKGQKKKSIEKKR 1007
+ Q + +K +++ E++R
Sbjct: 193 --------ERQRETDRKRDRQRESERER 212
Score = 65.9 bits (159), Expect = 3e-10
Identities = 57/219 (26%), Positives = 97/219 (44%), Gaps = 17/219 (7%)
Query: 1139 TSATPTNTTNNTFANE-----DSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLG 1193
T T+T T + ++ R+ R + K E H + + R+ ++
Sbjct: 5 TEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDRER 64
Query: 1194 SNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQ 1253
+++R R R D + ++ + DRE+ K E ER ++
Sbjct: 65 EKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRER 124
Query: 1254 LKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERER 1313
K+ E R +DR+ R R E +R+ + DR +ER+R +R+RER
Sbjct: 125 EKQKEMGRERQTDRETDRE---RERQAERERETGRER---KTEDRHRERER---ERKRER 175
Query: 1314 ER-RDTRQREWDRDADKDWPRNRDRDRLRERERERERDK 1351
ER R+T++RE R D + R R+ DR R+R+RE ER++
Sbjct: 176 ERKRETKERE--RHTDMERERQRETDRKRDRQRESERER 212
Score = 65.5 bits (158), Expect = 4e-10
Identities = 47/180 (26%), Positives = 80/180 (44%), Gaps = 13/180 (7%)
Query: 385 KQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKR------DREKDSREEREYEQ 438
K+S R R++ R + DR E++ D G+R DR++ ERE ++
Sbjct: 35 KESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDK 94
Query: 439 DQSSSRDHRDDREPRDGRDR--RDARDTRDRRELRDSRDMRDSREM-RDYSRDTKESRDP 495
++ + R DRE + ++R RD ++ R+ + RE R+ R + R+
Sbjct: 95 ERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERET 154
Query: 496 RDSRSTRDAHDYRDRE-GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
R T D H R+RE R+ RK +T E + + RE T+ + + + ES E
Sbjct: 155 GRERKTEDRHRERERERKRERERKRETKERERHT---DMERERQRETDRKRDRQRESERE 211
Score = 64.7 bits (156), Expect = 7e-10
Identities = 49/187 (26%), Positives = 81/187 (43%), Gaps = 9/187 (4%)
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERREDTRGK-RDREKDSREEREYEQDQSSSRDHRD 448
R R RE+ R +T H R +R+ R + RDR+++ ++ + E ++ R+
Sbjct: 23 RRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDR 82
Query: 449 DREPRDGRDRRDARDTRDRRELRDSRDMRDSREM---RDYSRDTKESRDPRDSRSTRDAH 505
DR+ R+R R+T E R + REM RD R+ K+ R+ ++ R+
Sbjct: 83 DRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRERE-KQKEMGRERQTDRETD 141
Query: 506 DYRDREG---RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
R+R+ R+T R+ T + R R RE + E + R+ R R
Sbjct: 142 RERERQAERERETGRERKT-EDRHRERERERKRERERKRETKERERHTDMERERQRETDR 200
Query: 563 SRGRVPE 569
R R E
Sbjct: 201 KRDRQRE 207
Score = 61.2 bits (147), Expect = 7e-09
Identities = 43/168 (25%), Positives = 70/168 (41%), Gaps = 17/168 (10%)
Query: 377 HSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREY 436
HS QR + R R RE+ + + +R +R +R+R+K+ +R
Sbjct: 43 HSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHT 102
Query: 437 EQDQSSS----------RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREM---- 482
E D+ RD +++ GR+R+ R+T RE + R+ RE
Sbjct: 103 ETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTED 162
Query: 483 --RDYSRDTKESRDPRDSRSTRDAHDYRDRE-GRDTHRKEDTYPEESR 527
R+ R+ K R+ + R+ H +RE R+T RK D E R
Sbjct: 163 RHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRESER 210
Score = 53.1 bits (126), Expect = 2e-06
Identities = 65/261 (24%), Positives = 116/261 (44%), Gaps = 67/261 (25%)
Query: 750 EREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIRE 809
E + E R E E +R+RER RE RERD+ +E + ED+ RD +R++
Sbjct: 2 ESKTEGRHTHTETET-MDRQRERRRETDRERDRAKESKT--EDRHSERDRQRDRERNRER 58
Query: 810 DRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVR 869
DR +R+ +K+ EG +R+RE D D R
Sbjct: 59 DR-------DREREKQTDREG--------ERQRERERDRD-------------------R 84
Query: 870 PQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILES 929
+E TE + + +E DR E ++ +E+E+ E+V D++RE+
Sbjct: 85 QRE---------TERERDKERETDRHTETDRERQKQKEREM-ERVR--DREREK------ 126
Query: 930 SRMRAQDIIGHHQSEDRETSDRAHD-ENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988
Q +G + DRET D E +++A+ +++ +++K +D ER E E
Sbjct: 127 -----QKEMGRERQTDRET-----DRERERQAERERETGRERKTEDRHRERER-ERKRER 175
Query: 989 GQVFSPKKGQKKKSIEKKRKK 1009
+ K+ ++ +E++R++
Sbjct: 176 ERKRETKERERHTDMERERQR 196
Score = 46.6 bits (109), Expect = 2e-04
Identities = 46/233 (19%), Positives = 82/233 (35%), Gaps = 22/233 (9%)
Query: 231 SKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRI 290
SK + + + + +D+QR + +++ D A K ++++ +DR
Sbjct: 3 SKTEGRHTHTETETMDRQRERRRETDRER-------------DRAKESKTEDRHSERDRQ 49
Query: 291 EEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR 350
++ R+ R RD +R+REK+ + R RH+ + R
Sbjct: 50 RDRERN---RERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDR 106
Query: 351 RKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSH 410
++ + R + + + R RE GR ER ++
Sbjct: 107 ERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGR---ERKTED- 162
Query: 411 DRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARD 463
RH RE R + K +ERE D R DR+ R+ RD
Sbjct: 163 --RHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 43.1 bits (100), Expect = 0.002
Identities = 44/227 (19%), Positives = 99/227 (43%), Gaps = 35/227 (15%)
Query: 87 ERMKNKRQDVDTE---PQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
+R + +R++ D E ++ TE+ S ++ R R+RE++ + +++T E E
Sbjct: 18 DRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRE 77
Query: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
E +RD + D E + + +++ + E E + RE +E E+ R
Sbjct: 78 RERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVRDRE-----REKQKEMGR 132
Query: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRT 263
+ + + R+ + +R+ + ++RKT D+ R + + +++ +
Sbjct: 133 ERQTDRETDRERERQAERERE------TGRERKTE-------DRHRERERERKRERERKR 179
Query: 264 PSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK-DRGRDFERQRE 309
+ K +E++ +R ++ D K DR R+ ER+R+
Sbjct: 180 ET-------------KERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 42.7 bits (99), Expect = 0.003
Identities = 47/227 (20%), Positives = 99/227 (43%), Gaps = 30/227 (13%)
Query: 98 TEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDIN 157
TE + +TE + ++E R RE++ K +K SE + + +R+ + D +
Sbjct: 5 TEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDR---QRDRERNRERDRD 61
Query: 158 YDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSK 217
+ + E +RQ+ +RE + Q E+ + + + E R + + +
Sbjct: 62 REREKQTDREGERQR-ERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERVR 120
Query: 218 SPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALG 277
+R+ + + DR+T D++R + + ++ G + ED
Sbjct: 121 DREREKQKEMGRERQTDRET--------DRERERQAERERETGRERKT------ED---- 162
Query: 278 KKYKEKYKVKDRIEEKTRDGKDRGR--DFERQRE-----KRDKPRST 317
+++E+ + + R E+ R+ K+R R D ER+R+ KRD+ R +
Sbjct: 163 -RHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQRES 208
Score = 40.4 bits (93), Expect = 0.014
Identities = 32/152 (21%), Positives = 68/152 (44%), Gaps = 11/152 (7%)
Query: 884 DRQGRWKEEDRKPER---KESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGH 940
DR K EDR ER ++ R E +E+ D++ E+ E R R ++
Sbjct: 32 DRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERE 91
Query: 941 HQSE---DRET-SDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKK 996
E DR T +DR + K++ + + +++K+ ++G ER T + + ++
Sbjct: 92 RDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERE----RQ 147
Query: 997 GQKKKSIEKKRKKSKGDSDISDEEAAQQSKKK 1028
++++ ++RK + E ++ +K+
Sbjct: 148 AERERETGRERKTEDRHRERERERKRERERKR 179
Score = 37.4 bits (85), Expect = 0.11
Identities = 28/149 (18%), Positives = 68/149 (45%), Gaps = 8/149 (5%)
Query: 882 TEDRQGRWKEE--DRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIG 939
TE R + E DR+ ER+ + R ++ + K +R++ E +R R +D
Sbjct: 5 TEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERDRQRDRERNRERDRD--- 61
Query: 940 HHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQK 999
E + +DR + +++ + + + + ++E D E T + Q ++ ++
Sbjct: 62 ---REREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMER 118
Query: 1000 KKSIEKKRKKSKGDSDISDEEAAQQSKKK 1028
+ E++++K G +D E ++ +++
Sbjct: 119 VRDREREKQKEMGRERQTDRETDRERERQ 147
Score = 34.7 bits (78), Expect = 0.74
Identities = 35/177 (19%), Positives = 72/177 (40%), Gaps = 15/177 (8%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R +R R+R + + + D E +++ E ++E+ R R +E+E + T+
Sbjct: 48 RQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRE 107
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
+++ E E RD E EM R++ E+E +RE ++
Sbjct: 108 RQKQKEREMERVRDRE----------REKQKEMGRERQTDRETDRERERQAERERETGRE 157
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSK 252
+ + R + RK + KR++ + + +R+ + D+QR S+
Sbjct: 158 RKTEDRHRER----ERERKRERERKRETKERERH-TDMERERQRETDRKRDRQRESE 209
Score = 32.3 bits (72), Expect = 3.7
Identities = 25/103 (24%), Positives = 44/103 (42%), Gaps = 10/103 (9%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQ---------KRNTEESSSPVRKESSRGRHREKE 125
++ ER +R+R + K++++ E Q +R E R+ + RHRE+E
Sbjct: 109 QKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERE 168
Query: 126 -DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLE 167
+ K +ER E++E + R+ D D E E
Sbjct: 169 RERKRERERKRETKERERHTDMERERQRETDRKRDRQRESERE 211
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 191 bits (485), Expect = 5e-48
Identities = 125/368 (33%), Positives = 205/368 (55%), Gaps = 32/368 (8%)
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVD 669
E D RD + R + + + + ++ I + R E ER+ RE R +R
Sbjct: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
Query: 670 DRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR 729
+R ER +E++RERER+R+R+R+R +ERDR+R++ER+ +R+R R +R +++ R RE+ R
Sbjct: 330 EREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSR 389
Query: 730 DRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERER-QR 788
DR+ +RERERERER+RE+ERERER ERERERERERERE++++R+RE E ER + +R
Sbjct: 390 DRERERERERERERERERERERER-EREREREREREREKDKKRDREEDEEDAYERRKLER 448
Query: 789 DWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDS 848
+K+ +R K EIRE + R+ E + ++ R E + + KR +E D
Sbjct: 449 KLREKEAAYQERL-KNWEIRERKKTREYEKEAEREEERRREMA----KEAKRLKEFLEDY 503
Query: 849 DAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWK--EEDRKPERKESSRRYE 906
D DD+++ P+ R + DR+ + E DRK E KE
Sbjct: 504 D-----DDRDD----------PKYYRGSALQKRLRDREKEMEADERDRKRE-KEELEEIR 547
Query: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKP 966
++ L E D + ++ E E+ R R I +SE+ E +E ++K + +++P
Sbjct: 548 QRLLAEGHPDPDAELQRME-QEAERRRQPQIKQEPESEEEE------EEKQEKEEKREEP 600
Query: 967 IKKKKEDD 974
+++++E +
Sbjct: 601 MEEEEEPE 608
Score = 186 bits (473), Expect = 1e-46
Identities = 116/320 (36%), Positives = 172/320 (53%), Gaps = 32/320 (10%)
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVD 669
E + + E+ ER+R RER++R R + R E E++ RE R DR
Sbjct: 293 EEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERER-DRDR 351
Query: 670 DRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR 729
DR ER R+RDRER+RDR+RER +R +DR R +E+ +RER RERERERE+ER+RER+R
Sbjct: 352 DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERER 411
Query: 730 DRDHDRERERERERDREKEREREREERE---------------------------RERER 762
+R+ +RERERERER+++K+R+RE +E + RER++
Sbjct: 412 EREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKK 471
Query: 763 ERERERERERERERARERDKERERQRDW-EDKDKGRDDRREKREEIREDRNPRDGHDERK 821
RE E+E ERE ER RE KE +R +++ ED D RDD + R + R RD E +
Sbjct: 472 TREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR-LRDREKEME 530
Query: 822 SKKRYRNEGSPSPRQSPKR-RREHSPDSDAYNSGDDKNEKHRLLSQVVR-PQESRSLSPS 879
+ +R R + +R E PD DA ++ + R Q+ + P+
Sbjct: 531 ADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEK 590
Query: 880 HLTEDRQGRWKEEDRKPERK 899
E+++ EE+ +PE+K
Sbjct: 591 QEKEEKREEPMEEEEEPEQK 610
Score = 163 bits (413), Expect = 1e-39
Identities = 126/487 (25%), Positives = 233/487 (47%), Gaps = 76/487 (15%)
Query: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDN----------RERDQRPSS 643
D W+ + + PE D E E RRD RE ++
Sbjct: 170 DEWKAKKKASNGNARPETVTNDDE-----EALDEETKRRDQMIKGAIEVLIREYSSELNA 224
Query: 644 PIRHQGRNDELERDERREE---------------------RRVDRVDDRRDERARERDRE 682
P + + ++ E++E+ ++ +D+RD +RE +
Sbjct: 225 PSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKF 284
Query: 683 RERDRERERER-ERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
R+ ++ E E+ ++E++R+ ++ ERER RERERER +ER+RER+R+R+ ++E+ERER
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERER-REREREREREREREKEKERER 343
Query: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
ER+R+++R+R + ER+R+R+RER+R+R+RER +R ++R + RE+ RD E + + +R
Sbjct: 344 ERERDRDRDRTK-ERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERE 402
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861
+RE RE R+ ER+ + R+ K+R + DAY +
Sbjct: 403 RERERERERERERERERERERE-----------REKDKKRDREEDEEDAY--------ER 443
Query: 862 RLLSQVVRPQESRSLSPSHLTEDRQ-GRWKEEDRKPERKESSRR---YEEQELKEKVSSV 917
R L + +R +E+ E R+ + +E +++ ER+E RR E + LKE +
Sbjct: 444 RKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDY 503
Query: 918 DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK------K 971
D R+ + S ++ + DRE A + ++K+ K + + I+++
Sbjct: 504 DDDRDDPKYYRGSALQ-------KRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
Query: 972 EDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGP 1031
+ D ++R E + +++ EK+ K+ K + + +EE +Q K P
Sbjct: 557 DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQ-KPCLKP 615
Query: 1032 RTPPITT 1038
PI++
Sbjct: 616 TLRPISS 622
Score = 129 bits (325), Expect = 2e-29
Identities = 115/376 (30%), Positives = 169/376 (44%), Gaps = 95/376 (25%)
Query: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRN-DRMGRSR 564
D RD R+ + DT+ + G+ +E R EI E R R R +R R R
Sbjct: 272 DKRDLISREISKFRDTHKKLEEEKGK----KEKERQEIEKERRERERERERERERRERER 327
Query: 565 GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER 624
R E R E++R ER+ RD+ RD + ER
Sbjct: 328 ERERE-----------------------------REREKEKERERERE-RDRDRDRTKER 357
Query: 625 RHGERDRRDNRERD-QRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDRE 682
+RDR +R+RD +R S + + R+ E RD RE ER +R +R ER RER+RE
Sbjct: 358 DR-DRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERE 416
Query: 683 RERDRERERERERERDRE--------------------------------------REKE 704
RER+RERERE++++RDRE RE E
Sbjct: 417 REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYE 476
Query: 705 RELERERAREREREREKERDRERDRDRDHDRERER--------ERERDREKEREREREER 756
+E ERE R RE +E +R +E D D DR+ + +R RDREKE E + +R
Sbjct: 477 KEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDR 536
Query: 757 ERERERERERERER---------ERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
+RE+E E E R+R + E +R E++ ER RQ + + + ++ EK+E+
Sbjct: 537 KREKE-ELEEIRQRLLAEGHPDPDAELQR-MEQEAERRRQPQIKQEPESEEEEEEKQEKE 594
Query: 808 REDRNPRDGHDERKSK 823
+ P + +E + K
Sbjct: 595 EKREEPMEEEEEPEQK 610
Score = 114 bits (286), Expect = 6e-25
Identities = 100/352 (28%), Positives = 164/352 (46%), Gaps = 38/352 (10%)
Query: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR 540
EM + RD R+ RD H + E ++ +E R R RE R
Sbjct: 268 EMEEDKRDLIS----REISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERR 323
Query: 541 TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS 600
R R R + + R R R + ++ R R + D D + RS
Sbjct: 324 EREREREREREREKEKERERERERDRDRDRTKERDR-DRDRERDRDRDRERSSDRNKDRS 382
Query: 601 SYPERDRYPERDNRDQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDELERDER 659
E+ R +R++ R+ ER R ER+R RER++ R + R E ++
Sbjct: 383 RSREKSR-----DRERERERERERERERERERERERERERE-----REREREREKDKKRD 432
Query: 660 REERRVDRVDDRRDER-ARERD---RERERDRE-RERERERERDREREKERELERERARE 714
REE D + R+ ER RE++ +ER ++ E RER++ RE ++E E+E E RE A+E
Sbjct: 433 REEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKE 492
Query: 715 REREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERER-- 772
+R +E D + DRD ++R R++E+E E +ER+R+RE+E E E R+R
Sbjct: 493 AKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKE-ELEEIRQRLL 551
Query: 773 --------------ERERARERDKERERQRDWEDKDKGRDDRREKREEIRED 810
E+E R R + +++ + E++++ + ++ EKREE E+
Sbjct: 552 AEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEE 603
Score = 112 bits (279), Expect = 4e-24
Identities = 99/353 (28%), Positives = 163/353 (46%), Gaps = 38/353 (10%)
Query: 463 DTRD--RRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKED 520
D RD RE+ RD E + + KE ++ R R+ R+RE R+ R+ +
Sbjct: 272 DKRDLISREISKFRDTHKKLE-EEKGKKEKERQEIEKERRERERERERERERRERERERE 330
Query: 521 TYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRG 580
E + R RE R+ R + R R+ R R R E+ S ++
Sbjct: 331 REREREKEKERERERERD-----RDRDRTKERDRDRDRERDRDRDR-----ERSSDRNK- 379
Query: 581 SQIDSHSSNSNYHDSWETRSSYPERDRYPERDN-RDQARDSSFER-RHGERDRRDNRERD 638
D S D R ER+R ER+ R++ R+ ER R E+D++ +RE D
Sbjct: 380 ---DRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
Query: 639 QRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERD 698
+ + R R +L E + R+ + R ++ RE ++E ER+ ER RE +E
Sbjct: 437 EEDAYERRKLER--KLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAK 494
Query: 699 REREKERELERER------------AREREREREKERDRERDRDRDHDR-ERERER---E 742
R +E + + +R R R+RE+E E D ERDR R+ + E R+R E
Sbjct: 495 RLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEAD-ERDRKREKEELEEIRQRLLAE 553
Query: 743 RDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDK 795
+ + E +R E+E ER R+ + ++E E E E +++KE +R+ E++++
Sbjct: 554 GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606
Score = 101 bits (251), Expect = 6e-21
Identities = 121/498 (24%), Positives = 198/498 (39%), Gaps = 80/498 (16%)
Query: 273 DIALGKK---YKEKYKVKDRIEE-----KTRDGKDRGR----DFERQREKRDKPRSTSPA 320
D+ +G+K K K K +++E K +G R D E ++ K R
Sbjct: 149 DLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIK 208
Query: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYP----- 375
G I R +SS + S P ++K ++R PL PYP
Sbjct: 209 GAIEVLI--REYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPL----IPYPLITKE 262
Query: 376 ----------SHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK-- 423
L S + + H+ EKG+ + ER +RR RE R +
Sbjct: 263 DINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERER 322
Query: 424 ----------RDREKDSREEREYE----QDQSSSRDHRDDREPRDGRDRRDARD-TRDRR 468
R+REK+ ERE E +D++ RD DRE RDR + D +DR
Sbjct: 323 REREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRS 382
Query: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRS 528
R+ R+ R+ R+ + R+ R+ R+ R+RE R+ +K D +E +
Sbjct: 383 RSREKSRDRERERERERERERERERE-RERERERERERERERE-REKDKKRDREEDEEDA 440
Query: 529 YGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSS 588
Y R L + E + R ++ EIR + R + E E+ R
Sbjct: 441 YERRKLERKLREKEAAYQERLKN-WEIRERKKTREYEKEAEREEERRREMAKEAKRLKEF 499
Query: 589 NSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQ 648
+Y D +RD+ R S+ ++R RDR E D+
Sbjct: 500 LEDYDD---------------DRDDPKYYRGSALQKR--LRDREKEMEADE--------- 533
Query: 649 GRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELE 708
R+ + E++E E R+ + D A + E+E +R R+ + ++E + E E+E + E
Sbjct: 534 -RDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQE 592
Query: 709 RERAREREREREKERDRE 726
+E RE E E+E +++
Sbjct: 593 KEEKREEPMEEEEEPEQK 610
Score = 100 bits (250), Expect = 8e-21
Identities = 89/348 (25%), Positives = 158/348 (45%), Gaps = 27/348 (7%)
Query: 1220 DQSGRKRVLHSGSRDREKTKSLEIT-GERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRS 1278
++ R + S+ R+ K LE G+++ ++++ R +R+ R R
Sbjct: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERER 329
Query: 1279 SPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRD 1338
E +R+ R+R +ERDR + DR +ER+R R+R+ DRD ++ RN+DR
Sbjct: 330 EREREREKEKE------RERERERDR-DRDRTKERDRDRDRERDRDRDRERSSDRNKDRS 382
Query: 1339 RLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
R RE+ R+RER++ R+ +RERER ER+R+R+R+R E + + R E + +
Sbjct: 383 RSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYE 442
Query: 1399 ERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGA 1458
R LE R+ A +ER+ ++ ++T + E+ EA +E + +
Sbjct: 443 RRKLERKLREKEAAYQERLKN--WEIRERKKTREYEK----EAEREEERRREMAKEAKRL 496
Query: 1459 GEGYEPISDDELD---------EILAGDAEKREDQQDEEKMPDPLDVIDVDWSGLMPKHP 1509
E E DD D + D EK + + ++ + ++ ++ L HP
Sbjct: 497 KEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHP 556
Query: 1510 KEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKP 1557
+P A L + A R K+ SE + K+ + E+P
Sbjct: 557 ----DPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEP 600
Score = 96.3 bits (238), Expect = 2e-19
Identities = 61/195 (31%), Positives = 100/195 (51%), Gaps = 4/195 (2%)
Query: 1251 IDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRE 1310
+++ KR SR S R + + E +RQ + R+R +ER+R E +RE
Sbjct: 269 MEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERE 328
Query: 1311 RERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERD 1370
RERER +++E +R+ ++D R+R ++R R+R+RER+RD+ R+ +R + S S E+
Sbjct: 329 REREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 1371 RDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEET 1430
RDR+R+R E E + E + E E ER+ E DK+R D++ +E
Sbjct: 389 RDRERERERER---EREREREREREREREREREREREREREKDKKR-DREEDEEDAYERR 444
Query: 1431 NKSERTESLEAGDDE 1445
+ EA E
Sbjct: 445 KLERKLREKEAAYQE 459
Score = 91.3 bits (225), Expect = 7e-18
Identities = 87/370 (23%), Positives = 155/370 (41%), Gaps = 52/370 (14%)
Query: 1149 NTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRS 1208
N E+ R + K H +E+ + +K +K + R R R R
Sbjct: 265 NAIEMEEDKRDLISREISKFRDTHKKLEEEKGKK---EKERQEIEKERRERERERERERE 321
Query: 1209 PSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQ 1268
R + + +++ R+RE+ + + T ER D+ + + R SSDR
Sbjct: 322 RREREREREREREREKEK---ERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRN 378
Query: 1269 DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDAD 1328
RS S R S + +R+ R+R +ER+R E +RERERER + ++ DR+ D
Sbjct: 379 KDRSRS-REKSRDRERERERERERERERERERERER-EREREREREREREKDKKRDREED 436
Query: 1329 -------------------------KDWP-RNRDRDRLRERERERERDKRRDLDRERERL 1362
K+W R R + R E+E ERE ++RR++ +E +RL
Sbjct: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496
Query: 1363 ISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLG 1422
+ D DRD + + S ++ R + E+++E+ RD +KE +++
Sbjct: 497 KEFLEDYDDDRDDPKYYRGSALQKRLR-------DREKEMEADERDRKR-EKEELEEIRQ 548
Query: 1423 SVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKRE 1482
+ + + +E + + EP S++E +E + EKRE
Sbjct: 549 RLLAEGHPDPDAELQRMEQEAERRRQPQIKQ---------EPESEEEEEEKQEKE-EKRE 598
Query: 1483 DQQDEEKMPD 1492
+ +EE+ P+
Sbjct: 599 EPMEEEEEPE 608
Score = 54.7 bits (130), Expect = 7e-07
Identities = 73/360 (20%), Positives = 129/360 (35%), Gaps = 42/360 (11%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R + + + + + +RQ+++ E ++R E R+E R R RE+E K KER
Sbjct: 285 RDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREK-EKERER 343
Query: 136 ESEEENVEWETNRDDSD-NGDINYDYVHELSLEMKRQKIQ-RELMKLEQENMEKREEIII 193
E E + T D D + + + D E S + + + + RE + + E+ E
Sbjct: 344 ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERER 403
Query: 194 KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSA---SKKDRKTSAVSSPLLDQQRN 250
++E E R + R+ K KR A K +RK + ++ +N
Sbjct: 404 EREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKN 463
Query: 251 ------SKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKY-----------------KVK 287
KT + +K+ R + ++ K++ E Y +++
Sbjct: 464 WEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLR 523
Query: 288 DRIEEKTRDGKDRGRDFERQREKRDK-------------PRSTSPAGQHHSPISSRHHSS 334
DR +E D +DR R+ E E R + R A + P + S
Sbjct: 524 DREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPES 583
Query: 335 SSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSP 394
+ ++ Q+ P R S PS S +S + P SP
Sbjct: 584 EEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESP 643
Score = 42.0 bits (97), Expect = 0.005
Identities = 37/222 (16%), Positives = 95/222 (42%), Gaps = 6/222 (2%)
Query: 864 LSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQ 923
++ + ++ R L +++ R K E+ K +KE R+ E+E +E+ +++RE+
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKG-KKEKERQEIEKERRERERERERERER 322
Query: 924 TEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIE 983
E R R ++ + E +R D ++ + K + + ++++ D ER +
Sbjct: 323 RE-----REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377
Query: 984 TTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELV 1043
+ ++++ E++R++ + + E ++ +++R +EE
Sbjct: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDE 437
Query: 1044 EMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTA 1085
E + + ++KE + ++ +R + E E A
Sbjct: 438 EDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEA 479
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 185 bits (469), Expect = 3e-46
Identities = 107/265 (40%), Positives = 159/265 (60%), Gaps = 26/265 (9%)
Query: 570 LPEKGSRGSRGSQIDSHSSN-SNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGE 628
+P SRG GSQ S H + ERDR E+ +++ RD +R
Sbjct: 45 IPLDFSRGRLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRR 104
Query: 629 RDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRE 688
+++ NR RD+ + E+ERD RE+++ R RERDR RER+R+
Sbjct: 105 KEKETNRNRDRE---------KQTEIERDREREKQK---------GRERERDRGRERERD 146
Query: 689 RERERERER--DREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDRE 746
R+RE+ERER +++R+ +RE E ER R+RERE++KER+ ERDRDR D E+ERER+ DRE
Sbjct: 147 RDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRE 206
Query: 747 KERERERE-ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE 805
++R+R+ + ER+RE +RE ERE +R RER+R R+R KER+R+RD +++ K + K+E
Sbjct: 207 RDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERK----KERKKE 262
Query: 806 EIREDRNPRDGHDERKSKKRYRNEG 830
+E + + R+ KKR EG
Sbjct: 263 RKKERKEKKKEEKRREDKKRKWGEG 287
Score = 170 bits (430), Expect = 1e-41
Identities = 93/215 (43%), Positives = 145/215 (67%), Gaps = 13/215 (6%)
Query: 653 ELERDERREERRVDRVDDRRDERARERDRERERDRERER-ERERERDREREKERELERER 711
+ + D+R+ ER DRV R++ +ERDR+R+RDRER R E+E R+R+REK+ E+ER+R
Sbjct: 71 DADGDDRQRER--DRV---REKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDR 125
Query: 712 AREREREREKERDRERDRDRDHDRERERERERDREKERERERE-ERERERERERERERER 770
RE+++ RE+ERDR R+R+RD DRE+ERER+ +++++ +RE E ERER+RERE+++ERE
Sbjct: 126 EREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERET 185
Query: 771 ERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEG 830
ER+R+R R+ +KERERQ D ++D+ R + E++ E DR D R+ ++R R+ G
Sbjct: 186 ERDRDRQRDTEKERERQTD-RERDRQRKTQTERQRE--TDREGERETDRRRERQRDRDRG 242
Query: 831 SPSPRQ---SPKRRREHSPDSDAYNSGDDKNEKHR 862
R+ +R++E + K EK R
Sbjct: 243 KERDRERDRKEERKKERKKERKKERKEKKKEEKRR 277
Score = 168 bits (426), Expect = 3e-41
Identities = 87/201 (43%), Positives = 135/201 (67%), Gaps = 6/201 (2%)
Query: 649 GRNDELERDERREERRVDRVDDR---RDERARERDRERERDRERERERERERDREREKER 705
G + + ERD RE+ +R DR R+ R +E++ R RDRE++ E ER+R+RE++K R
Sbjct: 74 GDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGR 133
Query: 706 ELERERARERERE--REKERDRERDRDRDHDRERERERERDREKERERERE-ERERERER 762
E ER+R RERER+ REKER+R+ ++DRD RE E ERERDRE+E+++ERE ER+R+R+R
Sbjct: 134 ERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQR 193
Query: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
+ E+ERER+ +RER R+R + ERQR+ + + + DRR +R+ R+ RD +RK
Sbjct: 194 DTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKE 253
Query: 823 KKRYRNEGSPSPRQSPKRRRE 843
+++ + + K++ E
Sbjct: 254 ERKKERKKERKKERKEKKKEE 274
Score = 135 bits (340), Expect = 3e-31
Identities = 88/265 (33%), Positives = 144/265 (54%), Gaps = 42/265 (15%)
Query: 524 EESRSYGRNHLREESSRTEIRNE-SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQ 582
E RS+G +++ + + E R ++E DR R R R EK + +R +
Sbjct: 58 ESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDR-DRKRDRERRRKEKETNRNRDRE 116
Query: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERD-NRDQARDSSFER-RHGERDRRDNRERDQR 640
+ + + R +R R ERD +R++ R+ E+ R G+R+ RERD+
Sbjct: 117 KQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDR- 175
Query: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRE 700
ER++++E RE +R+R+R R+ E+ERER+ DRE
Sbjct: 176 --------------EREKQKE---------------RETERDRDRQRDTEKERERQTDRE 206
Query: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
R+++R+ + ER RE +RE E+E DR R+R RD DR +ER+RERDR +EER++ER
Sbjct: 207 RDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDR-------KEERKKER 259
Query: 761 ERERERERERERERERARERDKERE 785
++ER++ER +E+++E R DK+R+
Sbjct: 260 KKERKKER-KEKKKEEKRREDKKRK 283
Score = 126 bits (316), Expect = 2e-28
Identities = 80/237 (33%), Positives = 139/237 (58%), Gaps = 29/237 (12%)
Query: 692 ERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERER 751
+R+RERDR REK E+ER R+R+R+RE+ R +E++ +R+ DRE++ E ERDRE+E+++
Sbjct: 76 DRQRERDRVREKT---EKERDRDRKRDRERRR-KEKETNRNRDREKQTEIERDREREKQK 131
Query: 752 EREERERERERERERERERERERERARERDKERERQRDWE---DKDKGRDDRREKREEIR 808
RE RER+R RERER+R+R +ER+++ E+ RD + + ++ RD REK++E R
Sbjct: 132 GRE-------RERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKE-R 183
Query: 809 EDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVV 868
E RD + + ++ + + ++ + R+ D + D + E+ R
Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQR---DRD 240
Query: 869 RPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE 925
R +E DR+ R ++E+RK ERK+ ++ +++ KE+ DK+R+ E
Sbjct: 241 RGKE----------RDRE-RDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGE 286
Score = 103 bits (256), Expect = 2e-21
Identities = 65/210 (30%), Positives = 109/210 (51%), Gaps = 7/210 (3%)
Query: 727 RDRDRDHDRERERERERDR-EKEREREREERERERERERERERERERERERARERDKERE 785
+D D D DR+RER+R R++ EKER+R+R+ R +E+E R R+RE++ ERD+ERE
Sbjct: 70 KDADGD-DRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDRERE 128
Query: 786 RQRDWE-DKDKGRD---DRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRR 841
+Q+ E ++D+GR+ DR ++E R+ RDG E ++++ E + +R
Sbjct: 129 KQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERD 188
Query: 842 REHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKES 901
R+ D++ E+ R Q T+ R+ R ++ DR ER
Sbjct: 189 RDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRE 248
Query: 902 SRRYEEQELKEKVSSVDKQREQTEILESSR 931
R EE++ KE+ K+R++ + E R
Sbjct: 249 RDRKEERK-KERKKERKKERKEKKKEEKRR 277
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/221 (28%), Positives = 106/221 (47%), Gaps = 9/221 (4%)
Query: 1184 MDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEI 1243
+ Q + G +R R R ++ R D + RK + +RDREK +E
Sbjct: 65 LGQAHKDADGDDRQ-RERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIER 123
Query: 1244 TGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERD 1303
ER+ + + + + R DR D R++ + D Q + + R+R ++++
Sbjct: 124 DREREKQKGRERERDRGRERERDR-DREKERERQTEKDRDGQRETETERERDREREKQKE 182
Query: 1304 RY-EHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERL 1362
R E DR+R+R+ R+R+ DR+ D+ +R R +RE ERE D+RR+ R+R+R
Sbjct: 183 RETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDR- 241
Query: 1363 ISDSVERDRDRDR--DRTFESSQIESVKRCEAKLEGEHERD 1401
ERDR+RDR +R E + +R E K E + D
Sbjct: 242 ---GKERDRERDRKEERKKERKKERKKERKEKKKEEKRRED 279
Score = 87.0 bits (214), Expect = 1e-16
Identities = 75/246 (30%), Positives = 115/246 (46%), Gaps = 21/246 (8%)
Query: 1183 PMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDD-QSGRKRVLHSGSRDREKTKSL 1241
P+D R LGS S RS G+ ++ GDD Q R RV ++R++ +
Sbjct: 46 PLDFSRGR-LGSQESPRSWGLGQAHKDAD------GDDRQRERDRVREKTEKERDRDRKR 98
Query: 1242 EITGERKSRI-----DQLKRGEPSRSTSSDRQDSRSHS---SRRSSPESDRQVHSRSGSF 1293
+ RK + D+ K+ E R ++Q R R + DR+ +
Sbjct: 99 DRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTE 158
Query: 1294 DSRDRLQERD-RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
RD +E + E DRERE+++ +R+ DR D + R R DR R+R+R+ + +++
Sbjct: 159 KDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQ 218
Query: 1353 RDLDRERERLISDSVERDRDRDR--DRTFESSQIESVKRCEAKLEGEHERDLESTSRDSL 1410
R+ DRE ER ER RDRDR +R E + E K+ E K E + ER E +
Sbjct: 219 RETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK-ERKKERKKERK-EKKKEEKR 276
Query: 1411 ALDKER 1416
DK+R
Sbjct: 277 REDKKR 282
Score = 85.5 bits (210), Expect = 4e-16
Identities = 74/293 (25%), Positives = 128/293 (43%), Gaps = 79/293 (26%)
Query: 744 DREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREK 803
DR++ER+R RE+ E+ER+R+R+R+RER R ++KE R RD REK
Sbjct: 76 DRQRERDRVREKTEKERDRDRKRDRERRR-------KEKETNRNRD-----------REK 117
Query: 804 REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRR-REHSPDSDAYNSGDDKNEKHR 862
+ EI DR +++K ++R R+ G R + + RE + D + + E+ R
Sbjct: 118 QTEIERDRE----REKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERER 173
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQRE 922
DR+ R K+++R+ ER +R E KE+ D++R+
Sbjct: 174 ---------------------DRE-REKQKERETERDRDRQRDTE---KERERQTDRERD 208
Query: 923 QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNI 982
+ ++ R R D G +++ R R D K++ +E D
Sbjct: 209 RQRKTQTERQRETDREGERETDRRRERQRDRDRGKER----------DRERD-------- 250
Query: 983 ETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPP 1035
+K ++KK +K+RKK + + +E+ + K+K G P
Sbjct: 251 ------------RKEERKKERKKERKKERKEKK-KEEKRREDKKRKWGEGISP 290
Score = 79.3 bits (194), Expect = 3e-14
Identities = 63/224 (28%), Positives = 104/224 (46%), Gaps = 16/224 (7%)
Query: 1172 HVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSG 1231
H + ++ D+ R + +R R R + +R + Q+ +R
Sbjct: 69 HKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIER----- 123
Query: 1232 SRDREKTKSLEITGER--KSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSR 1289
R+REK K E +R + D+ + E R T DR R + R E DR+ +
Sbjct: 124 DREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETER---ERDREREKQ 180
Query: 1290 SGSFDSRDRLQERDRYEHDRERERERRDTRQR----EWDRDADKDWPRNRDRDRLRERER 1345
RDR ++RD E +RER+ +R RQR E R+ D++ R DR R R+R+R
Sbjct: 181 KERETERDRDRQRDT-EKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDR 239
Query: 1346 ERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
+R +++ R+ DR+ ER ER ++R +++ E + E KR
Sbjct: 240 DRGKERDRERDRKEERKKERKKERKKER-KEKKKEEKRREDKKR 282
Score = 79.3 bits (194), Expect = 3e-14
Identities = 68/258 (26%), Positives = 114/258 (44%), Gaps = 55/258 (21%)
Query: 454 DGRDRRDARD-TRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREG 512
DG DR+ RD R++ E RD + RE R ++T +RD + ++G
Sbjct: 73 DGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKG 132
Query: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572
R+ R+ D E R R+ +E +TE + + E+ +E DR
Sbjct: 133 RE--RERDRGRERERD--RDREKERERQTEKDRDGQRETETERERDR------------- 175
Query: 573 KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER-----RHG 627
+ + D R + ER+R +R+ RD+ R + ER R G
Sbjct: 176 ---------EREKQKERETERDRDRQRDTEKERERQTDRE-RDRQRKTQTERQRETDREG 225
Query: 628 ER--DRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERER 685
ER DRR R+RD+ +R +ER DR DR++ER +ER +ER++
Sbjct: 226 ERETDRRRERQRDR------------------DRGKER--DRERDRKEERKKERKKERKK 265
Query: 686 DRERERERERERDREREK 703
+R+ +++ E+ R+ ++ K
Sbjct: 266 ERKEKKKEEKRREDKKRK 283
Score = 72.8 bits (177), Expect = 2e-12
Identities = 56/202 (27%), Positives = 89/202 (44%), Gaps = 16/202 (7%)
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDH-RD 448
R R +REK + +R + R + ++T RDREK + ER+ E+++ R+ RD
Sbjct: 79 RERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERD 138
Query: 449 -------DREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRD-PRDSRS 500
DR+ R+R+ +D +RE R+ RD + R+T+ RD RD+
Sbjct: 139 RGRERERDRDREKERERQTEKDRDGQRETETERE-RDREREKQKERETERDRDRQRDTEK 197
Query: 501 TRDAHDYRDREGR---DTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRN 557
R+ R+R+ + T R+ +T E R R R E R R + R+ R
Sbjct: 198 ERERQTDRERDRQRKTQTERQRETDREGERETDR---RRERQRDRDRGKERDRERDRKEE 254
Query: 558 DRMGRSRGRVPELPEKGSRGSR 579
+ R + R E EK R
Sbjct: 255 RKKERKKERKKERKEKKKEEKR 276
Score = 70.9 bits (172), Expect = 9e-12
Identities = 53/188 (28%), Positives = 87/188 (46%), Gaps = 9/188 (4%)
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
R + R R ++ + +R Q+ R RE +G R+RE+D ERE ++D+
Sbjct: 94 RDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKG-RERERDRGRERERDRDREKE 152
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS--- 500
R+ R + RDG +R+ R+R R+ + R++ RD RDT++ R+ + R
Sbjct: 153 RE-RQTEKDRDG--QRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDR 209
Query: 501 TRDAHDYRDRE-GRDTHRKEDTYPEESRSYGRNHLRE-ESSRTEIRNESRNESRSEIRND 558
R R RE R+ R+ D E R R R+ E R E R + R + R + R +
Sbjct: 210 QRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKE 269
Query: 559 RMGRSRGR 566
+ + R
Sbjct: 270 KKKEEKRR 277
Score = 70.1 bits (170), Expect = 2e-11
Identities = 54/191 (28%), Positives = 86/191 (45%), Gaps = 14/191 (7%)
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQ-SHDRRHER-----REDTRGK---RDREKDSREER 434
RK+ R R D E+ ++ DR E+ RE RG+ RDR+++ ER
Sbjct: 96 RKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERER 155
Query: 435 EYEQDQSSSRDHRDDREPRDGRDRRDARDT-RDRRELRDS---RDMRDSREMRDYSRDTK 490
+ E+D+ R+ +RE R+++ R+T RDR RD+ R+ + RE RD R T+
Sbjct: 156 QTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRE-RDRQRKTQ 214
Query: 491 ESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNE 550
R R D R RD R ++ E R R R++ + E + + + E
Sbjct: 215 TERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEE 274
Query: 551 SRSEIRNDRMG 561
R E + + G
Sbjct: 275 KRREDKKRKWG 285
Score = 69.3 bits (168), Expect = 3e-11
Identities = 60/211 (28%), Positives = 96/211 (45%), Gaps = 23/211 (10%)
Query: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRS-NRSHTSGRLRSPSN 1211
+ D R R R EK ET + Q D++R G R +R R R
Sbjct: 93 DRDRKRDRERRRKEK-ETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREK 151
Query: 1212 DSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQ-DS 1270
+ ++ D+ G++ RDRE+ K E ER DRQ D+
Sbjct: 152 ERERQTEKDRDGQRETETERERDREREKQKERETER----------------DRDRQRDT 195
Query: 1271 RSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKD 1330
R++ E DRQ +++ DR ER E DR RER+R R +E DR+ D+
Sbjct: 196 EKERERQTDRERDRQRKTQTERQRETDREGER---ETDRRRERQRDRDRGKERDRERDRK 252
Query: 1331 WPRNRDRDRLRERER-ERERDKRRDLDRERE 1360
R ++R + R++ER E++++++R D++R+
Sbjct: 253 EERKKERKKERKKERKEKKKEEKRREDKKRK 283
Score = 67.0 bits (162), Expect = 1e-10
Identities = 56/249 (22%), Positives = 102/249 (40%), Gaps = 28/249 (11%)
Query: 271 PEDIALGKKYKE-----KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325
P LG+ +K+ + + +DR+ EKT +DR R +R+R +++K + + + +
Sbjct: 60 PRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQT 119
Query: 326 PISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRK 385
I R Q G +R R + + T ++
Sbjct: 120 EIE-RDREREKQKGRERERDRGRERERDRDREKERERQT------------------EKD 160
Query: 386 QSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445
+ R RE+ R ++ + +R +R+ DT +R+R+ D ER+ ++ + R
Sbjct: 161 RDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTD--RERDRQRKTQTERQ 218
Query: 446 HRDDREPRDGRDRRDARD-TRDRRELRD-SRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
DRE DRR R RDR + RD RD ++ R+ KE ++ + R+
Sbjct: 219 RETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRRE 278
Query: 504 AHDYRDREG 512
+ EG
Sbjct: 279 DKKRKWGEG 287
Score = 64.7 bits (156), Expect = 7e-10
Identities = 74/307 (24%), Positives = 131/307 (42%), Gaps = 49/307 (15%)
Query: 370 SASPYPSHSLSSPQRKQSPPRHRS----------PMR-EKGRHDHERTSQSHDRRHERRE 418
++SP + L P +P H S P+ +GR + + +S ++
Sbjct: 12 NSSPVKTSPLLVPSLTYAPHLHSSLGTLWVEVTIPLDFSRGRLGSQESPRSWGLGQAHKD 71
Query: 419 DTRGKRDREKDS-REEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR 477
R RE+D RE+ E E+D+ RD R+ ++ RD R+ + E R+ +
Sbjct: 72 ADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRD-REKQTEIERDREREKQ 130
Query: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREE 537
RE R+ R + RD RD R+ +DR+G+ R+ +T E R + RE
Sbjct: 131 KGRE-RERDRGRERERD-RDREKERERQTEKDRDGQ---RETETERERDREREKQKERET 185
Query: 538 SSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE 597
R+ R + R + R R R ++ ++ R + D
Sbjct: 186 E-----RDRDRQRDTEKERERQTDRERDR-----QRKTQTERQRETD------------- 222
Query: 598 TRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERD 657
R E DR ER RD+ R +R ERDR++ R+++++ R + R ++ + +
Sbjct: 223 -REGERETDRRRER-QRDRDRGKERDR---ERDRKEERKKERKKE---RKKERKEKKKEE 274
Query: 658 ERREERR 664
+RRE+++
Sbjct: 275 KRREDKK 281
Score = 54.7 bits (130), Expect = 7e-07
Identities = 46/153 (30%), Positives = 68/153 (44%), Gaps = 24/153 (15%)
Query: 1317 DTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD---- 1372
D RQRE DR +K + RDRDR R+RER R K ++ +R R+R +ERDR+
Sbjct: 75 DDRQRERDRVREKT-EKERDRDRKRDRERRR---KEKETNRNRDREKQTEIERDREREKQ 130
Query: 1373 --------------RDRDRTFE-SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERM 1417
RDRDR E Q E + + + E E ERD E + +++R
Sbjct: 131 KGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDR- 189
Query: 1418 DKDLGSVQGFEETNKSERTESLEAGDDESKLDD 1450
D+ + + E ER + + + D
Sbjct: 190 DRQRDTEKERERQTDRERDRQRKTQTERQRETD 222
Score = 45.8 bits (107), Expect = 3e-04
Identities = 44/171 (25%), Positives = 68/171 (39%), Gaps = 13/171 (7%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITK--- 131
RR E+ T R+R K + D E +K+ E +E R R REKE + T+
Sbjct: 102 RRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDR 161
Query: 132 --ERTPESE-------EENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQ 182
+R E+E E+ E ET RD D + + E RQ+ + + + +
Sbjct: 162 DGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQR-KTQTERQRE 220
Query: 183 ENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK 233
+ E E ++E + R K RK + +RK K KK
Sbjct: 221 TDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKK 271
Score = 45.4 bits (106), Expect = 4e-04
Identities = 46/250 (18%), Positives = 108/250 (43%), Gaps = 25/250 (10%)
Query: 64 SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHRE 123
SPR G ++ + GD R+R +++ ++ + + R+ + RKE R+R+
Sbjct: 59 SPRSWGLGQAHKDAD----GDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRD 114
Query: 124 KEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQE 183
+E K T+ E+ E RD + + D E + ++ + + + E+E
Sbjct: 115 RE--KQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERE 172
Query: 184 NMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSP 243
+RE K+ E R + + ++ + R+ + + +++ R+T
Sbjct: 173 RDRERE-----KQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGER 227
Query: 244 LLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRD 303
D++R + ++ + K D +K + K K+R +E+ ++ K++ ++
Sbjct: 228 ETDRRRERQRDRDRGK-----------ERDRERDRKEERK---KERKKERKKERKEKKKE 273
Query: 304 FERQREKRDK 313
+R+ +K+ K
Sbjct: 274 EKRREDKKRK 283
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/196 (20%), Positives = 80/196 (40%), Gaps = 39/196 (19%)
Query: 873 SRSLSPSHLTEDRQGRWKEEDRKPERKESSR-----RYEEQELKEKVSSVDKQRE-QTEI 926
S L +H D R +E DR E+ E R R E+ KEK ++ ++ RE QTEI
Sbjct: 62 SWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEI 121
Query: 927 -----------------------------LESSRMRAQDIIGHHQSEDRETSDRAHDENK 957
E R +D G ++E DR ++ K
Sbjct: 122 ERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQK 181
Query: 958 KKA----KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD 1013
++ + +++ +K++E ER T + Q + ++G+++ ++R++ +
Sbjct: 182 ERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDR 241
Query: 1014 SDISDEEAAQQSKKKR 1029
D E ++ ++K+
Sbjct: 242 GKERDRERDRKEERKK 257
Score = 32.3 bits (72), Expect = 3.7
Identities = 26/149 (17%), Positives = 67/149 (44%), Gaps = 16/149 (10%)
Query: 899 KESSRRYEEQELKEKVSSVDKQREQTEILESS-------------RMRAQDIIGHHQSED 945
+ES R + + + D+QRE+ + E + R R + ++ +
Sbjct: 57 QESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDRE 116
Query: 946 RETS-DRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIE 1004
++T +R + K+K + +++ +++E D E+ T +D ++ + ++ +
Sbjct: 117 KQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRD--GQRETETERERD 174
Query: 1005 KKRKKSKGDSDISDEEAAQQSKKKRGPRT 1033
++R+K K D + + ++K+R +T
Sbjct: 175 REREKQKERETERDRDRQRDTEKERERQT 203
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 183 bits (465), Expect = 1e-45
Identities = 95/209 (45%), Positives = 145/209 (69%), Gaps = 17/209 (8%)
Query: 628 ERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDR 687
ER R RE D+ G+ E ERD +RE ++R +R R R+R+R+ DR
Sbjct: 2 ERQRERKRETDR---------GKETERERDRQRERENQTERENRHRQRDRHRERDRQTDR 52
Query: 688 ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREK 747
E+ERER++ERDR+R++ERE ERE R+RER+R++ER R+ DR+RD DR+RER+RE DR +
Sbjct: 53 EKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNR 112
Query: 748 ERER----EREER-ERERERERERERERERERERARERDKERERQRD-WEDKDKGRDDRR 801
ER R ER+++ ERER+RERER+R+RERER+R RER +E +R+R W ++++ + +R+
Sbjct: 113 ERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERK 172
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNEG 830
++R++ R+++ + R+ KKR EG
Sbjct: 173 KERKKERKEKKKEE--KRREDKKRKWGEG 199
Score = 163 bits (413), Expect = 1e-39
Identities = 82/183 (44%), Positives = 129/183 (70%), Gaps = 8/183 (4%)
Query: 604 ERDRYPERDNRDQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE 662
ERDR ER+N+ + + +R RH ERDR+ +RE+++ Q D + ER E
Sbjct: 20 ERDRQRERENQTERENRHRQRDRHRERDRQTDREKERE------RQKERDRQRQRERETE 73
Query: 663 RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722
R +R +R+ +R R+R +RERD++R+RER+RE DR RE+ R+ RER ++ ERER++E
Sbjct: 74 RETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRERDKQTERERDRE 133
Query: 723 RDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDK 782
R+R+R R+R+ R+RER+RE DRE++R EREER++ER++ER++ER +E+++E R DK
Sbjct: 134 RERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKER-KEKKKEEKRREDK 192
Query: 783 ERE 785
+R+
Sbjct: 193 KRK 195
Score = 161 bits (407), Expect = 5e-39
Identities = 87/201 (43%), Positives = 142/201 (70%), Gaps = 8/201 (3%)
Query: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
ER R +R+ D+ +++ ER +R+R + ER+ R RH+ R+ + +R++ RE R
Sbjct: 2 ERQRERKRET-DRGKETERERDR-QRERENQTERENRHRQRDRHRERDRQTDREKERE-R 58
Query: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKER 723
+ +R R+ ER ER+ ER+R+R+R+RER+R+ DRER+K+R+ ER+R +R RER ++
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKG 118
Query: 724 DRERDRDRDHDRERERERERDREKERERERE-ERERERERERERERERERERERARERDK 782
RERD+ + +R+RERER+R RE+ER+R+RE +RE +RER+R ERE ER++ER +ER K
Sbjct: 119 GRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAERE-ERKKERKKERKK 177
Query: 783 ERERQRDWEDKDKGRDDRREK 803
ER+ ++ ++K R+D++ K
Sbjct: 178 ERKEKK---KEEKRREDKKRK 195
Score = 159 bits (403), Expect = 2e-38
Identities = 85/203 (41%), Positives = 140/203 (68%), Gaps = 10/203 (4%)
Query: 614 RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRD 673
R++ R++ + ER+R RER+ + RH+ R+ ERD R+ +R +R +
Sbjct: 5 RERKRETD-RGKETERERDRQRERENQTERENRHRQRDRHRERD-RQTDREKERERQKER 62
Query: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733
+R R+R+RE ER+ ER+RER+R+R+R+R+ +RE +++R RER+RE ++ R+R R R+
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRER 122
Query: 734 DRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDK 793
D++ ERER+R+RE++R+RER ER+R+RER+RE +RER+R ER ER KER+++R E K
Sbjct: 123 DKQTERERDRERERQRQRER-ERQRQRERKRETDRERQRWAER-EERKKERKKERKKERK 180
Query: 794 DKGRDDRREKREEIREDRNPRDG 816
+K ++++R RED+ + G
Sbjct: 181 EKKKEEKR------REDKKRKWG 197
Score = 148 bits (374), Expect = 4e-35
Identities = 90/250 (36%), Positives = 145/250 (58%), Gaps = 55/250 (22%)
Query: 678 ERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRER 737
ER RER+R+ +R +E ERERDR+RE+E + ERE R R+++R RERDR D ++ER
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTEREN-----RHRQRDRHRERDRQTDREKER 56
Query: 738 ERERERDREKERERERE-ERERERERERERERERERERERARERDKERERQRDWEDKDKG 796
ER++ERDR+++RERE E E ER+RER+R+RER+R+ +RER ++RD+ER+R+ D ++++
Sbjct: 57 ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETD-RNRERN 115
Query: 797 RDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDD 856
R RE+ ++ +R D + ++R R + +R+RE ++D
Sbjct: 116 RKGGRERDKQTERER------DRERERQRQR-------ERERQRQRERKRETD------- 155
Query: 857 KNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKE-EDRKPERKESSRRYEEQELKEKVS 915
+RQ RW E E+RK ERK+ ++ +++ KE+
Sbjct: 156 --------------------------RERQ-RWAEREERKKERKKERKKERKEKKKEEKR 188
Query: 916 SVDKQREQTE 925
DK+R+ E
Sbjct: 189 REDKKRKWGE 198
Score = 112 bits (280), Expect = 3e-24
Identities = 78/203 (38%), Positives = 111/203 (54%), Gaps = 15/203 (7%)
Query: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607
R R R R R R E + R +R Q D H D + R ERDR
Sbjct: 5 RERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDR 64
Query: 608 YPERDNRDQARDSSFER---RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664
+R+ R+ R++ +R R ER R+ +RERD+ R + R E +R+ R R+
Sbjct: 65 QRQRE-RETERETERQRERQRQRERKRQTDRERDKD-----RDRERKRETDRNRERN-RK 117
Query: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724
R D++ ER ERDRERER R+RERER+R+R+R+RE +R ER+R ERE ER+KER
Sbjct: 118 GGRERDKQTER--ERDRERERQRQRERERQRQRERKRETDR--ERQRWAERE-ERKKERK 172
Query: 725 RERDRDRDHDRERERERERDREK 747
+ER ++R ++ E+ RE + K
Sbjct: 173 KERKKERKEKKKEEKRREDKKRK 195
Score = 101 bits (252), Expect = 5e-21
Identities = 73/254 (28%), Positives = 117/254 (46%), Gaps = 55/254 (21%)
Query: 724 DRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKE 783
+R+R+R R+ DR +E ERERDR++ERE + E R R+R+R RER+R+ +RE+ RER KE
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 784 RERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE 843
R+RQ R+ +RE RE R+ +R+ K++ E + R RE
Sbjct: 62 RDRQ------------RQRERETERETERQRERQRQRERKRQTDRE------RDKDRDRE 103
Query: 844 HSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSR 903
++D + K + R D+Q +E DR+ ER+
Sbjct: 104 RKRETDRNRERNRKGGRER---------------------DKQTE-RERDRERERQRQRE 141
Query: 904 RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQ 963
R E Q +E+ D++R++ + +E E K+K K +
Sbjct: 142 R-ERQRQRERKRETDRERQRW--------------AEREERKKERKKERKKERKEKKKEE 186
Query: 964 KKPIKKKKEDDVGI 977
K+ KK++ GI
Sbjct: 187 KRREDKKRKWGEGI 200
Score = 91.7 bits (226), Expect = 5e-18
Identities = 66/194 (34%), Positives = 95/194 (48%), Gaps = 17/194 (8%)
Query: 1241 LEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ 1300
+E ERK D+ K E R +R++ +R + R+ ++ R+R +
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQK 60
Query: 1301 ERDRY-----------EHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERE--R 1347
ERDR E RER+R+R RQ + +RD D+D R R+ DR RER R+ R
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGR 120
Query: 1348 ERDKR--RDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLEST 1405
ERDK+ R+ DRERER ER R R+R R + + +R E K E + ER E
Sbjct: 121 ERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKE-- 178
Query: 1406 SRDSLALDKERMDK 1419
++ +K R DK
Sbjct: 179 RKEKKKEEKRREDK 192
Score = 84.0 bits (206), Expect = 1e-15
Identities = 60/194 (30%), Positives = 101/194 (52%), Gaps = 12/194 (6%)
Query: 1221 QSGRKRVLHSGS---RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRR 1277
Q RKR G R+R++ + E ER++R Q R R +DR+ R R
Sbjct: 4 QRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHR-ERDRQTDREKERERQKER 62
Query: 1278 SSP-ESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRD 1336
+ +R+ + R R +ER R + DRER+++R R+RE DR+ +++ R+
Sbjct: 63 DRQRQRERETERETERQRERQRQRERKR-QTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 1337 RDRL--RERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKL 1394
RD+ RER+RERER ++R+ +R+R+R +R+ DR+R R E + + ++ E K
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQR----ERKRETDRERQRWAEREERKKERKKERKK 177
Query: 1395 EGEHERDLESTSRD 1408
E + ++ E D
Sbjct: 178 ERKEKKKEEKRRED 191
Score = 80.5 bits (197), Expect = 1e-14
Identities = 62/216 (28%), Positives = 100/216 (46%), Gaps = 32/216 (14%)
Query: 1266 DRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY--EHDRERERERRDTRQREW 1323
+RQ R + R E++R+ RDR +ER+ +R R+R+R R R+
Sbjct: 2 ERQRERKRETDRGK-ETERE----------RDRQRERENQTERENRHRQRDRHRERDRQT 50
Query: 1324 DRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFES-- 1381
DR+ +++ + RDR R RERE ERE +++R+ R+RER ERD+DRDR+R E+
Sbjct: 51 DREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDR 110
Query: 1382 -------------SQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFE 1428
Q E + E + + + ER+ + D+ER + + +
Sbjct: 111 NRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRER-QRWAEREERKK 169
Query: 1429 ETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEP 1464
E K + E E +E + +D GEG P
Sbjct: 170 ERKKERKKERKEKKKEEKRREDKKRKW---GEGISP 202
Score = 72.8 bits (177), Expect = 2e-12
Identities = 69/262 (26%), Positives = 108/262 (41%), Gaps = 73/262 (27%)
Query: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524
R R R++ +++ RD R+ + + + RD H RDR+ T R+++ +
Sbjct: 3 RQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQ---TDREKERERQ 59
Query: 525 ESRSYGRNHLREESSRTEIRNESRNESRSEIRNDR---MGRSRGRVPELPEKGSRGSRGS 581
+ R R RE TE + E + + + + DR R R R E R +G
Sbjct: 60 KERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGG 119
Query: 582 QIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRP 641
+ ERD+ ER+ R ER+R+ RER
Sbjct: 120 R---------------------ERDKQTERE------------RDRERERQRQRER---- 142
Query: 642 SSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRER 701
ER +RE +R E DRER+R ERE ER++ER +ER
Sbjct: 143 -------------ERQRQRERKR-------------ETDRERQRWAERE-ERKKERKKER 175
Query: 702 EKERELERERAREREREREKER 723
+KER +E+ +E +R +K+R
Sbjct: 176 KKER---KEKKKEEKRREDKKR 194
Score = 70.9 bits (172), Expect = 9e-12
Identities = 53/195 (27%), Positives = 93/195 (47%), Gaps = 6/195 (3%)
Query: 1196 RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLK 1255
R + T + R ++Q+ R+ R RE+ + + ER+ + ++ +
Sbjct: 5 RERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDR 64
Query: 1256 RGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY-EHDRERERE 1314
+ + R T + + R +R E RQ R+R +E DR E +R+ RE
Sbjct: 65 QRQRERETERETERQRERQRQR---ERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 1315 RRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRD 1374
R +RE DR+ ++ R R+R R RER+RE +R+++R +RE ER ER ++R
Sbjct: 122 RDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAERE-ERKKERKKERKKER- 179
Query: 1375 RDRTFESSQIESVKR 1389
+++ E + E KR
Sbjct: 180 KEKKKEEKRREDKKR 194
Score = 70.5 bits (171), Expect = 1e-11
Identities = 50/186 (26%), Positives = 84/186 (45%), Gaps = 11/186 (5%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
+RK+ R + RE+ R + RH +R+ R RE+D + +RE E+++
Sbjct: 6 ERKRETDRGKETERERDRQRERENQTERENRHRQRD-----RHRERDRQTDREKERERQK 60
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDM-RDSREMRDYSRDTKESRDPRDSRST 501
RD + RE R+ R+ + +RE + D RD R+ R+T +R+ R+ +
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRE-RNRKGG 119
Query: 502 RDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE---ESSRTEIRNESRNESRSEIRND 558
R+ +RE RD R+ E R R RE E R R E + E + E + +
Sbjct: 120 RERDKQTERE-RDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKE 178
Query: 559 RMGRSR 564
R + +
Sbjct: 179 RKEKKK 184
Score = 68.9 bits (167), Expect = 4e-11
Identities = 65/270 (24%), Positives = 108/270 (40%), Gaps = 76/270 (28%)
Query: 433 EREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKES 492
ER+ E+ + + R +RE R+R + + +R RD RD + R+ R+ ++
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 493 RDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESR 552
RD R R+ +T E R R RE +T+ R ++ R
Sbjct: 62 RD------------------RQRQRERETERETERQRERQRQRERKRQTD-RERDKDRDR 102
Query: 553 SEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERD 612
R R R R KG R ERD+ ER+
Sbjct: 103 ERKRETDRNRERNR------KGGR---------------------------ERDKQTERE 129
Query: 613 NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRR 672
R ER+R+ RER+++ R E +R+ RE +R ++R+
Sbjct: 130 ------------RDRERERQRQRERERQ---------RQRERKRETDRERQRWAEREERK 168
Query: 673 DERARERDRERERDRERERERERERDRERE 702
ER +ER +ER +E+++E +R D++R+
Sbjct: 169 KERKKERKKER---KEKKKEEKRREDKKRK 195
Score = 68.6 bits (166), Expect = 5e-11
Identities = 58/232 (25%), Positives = 98/232 (42%), Gaps = 42/232 (18%)
Query: 411 DRRHERREDT-RGKR-DREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRR 468
+R+ ER+ +T RGK +RE+D + ERE + ++ + RD RD + R+ R+R+
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKE--RERQ 59
Query: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRS 528
+ RD + R+ R+ R+T+ R+ + R + D + RD RK +T + +R
Sbjct: 60 KERDRQRQRE----RETERETERQRERQRQRERKRQTDRERDKDRDRERKRET--DRNRE 113
Query: 529 YGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSS 588
R RE +TE R R R R R R R
Sbjct: 114 RNRKGGRERDKQTE-RERDRERERQRQRERERQRQRER---------------------- 150
Query: 589 NSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR 640
R + ER R+ ER+ R + R ++ E+ + + R D++
Sbjct: 151 ---------KRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKK 193
Score = 68.2 bits (165), Expect = 6e-11
Identities = 54/201 (26%), Positives = 96/201 (47%), Gaps = 25/201 (12%)
Query: 1169 ETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVL 1228
E T + + D++R + R NR R HR D Q+ R++
Sbjct: 6 ERKRETDRGKETERERDRQRERENQTERENRHRQRDR---------HRERDRQTDREKER 56
Query: 1229 H-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR-QV 1286
RDR++ + E E + + ++ ++ E R T +R R +R E+DR +
Sbjct: 57 ERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKR---ETDRNRE 113
Query: 1287 HSRSGSFD-------SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDR 1339
+R G + RDR +ER R + +RER+R+R R+RE DR+ + W +R +
Sbjct: 114 RNRKGGRERDKQTERERDRERERQR-QRERERQRQRE--RKRETDRERQR-WAEREERKK 169
Query: 1340 LRERERERERDKRRDLDRERE 1360
R++ER++ER +++ ++ RE
Sbjct: 170 ERKKERKKERKEKKKEEKRRE 190
Score = 59.7 bits (143), Expect = 2e-08
Identities = 45/201 (22%), Positives = 88/201 (43%), Gaps = 16/201 (7%)
Query: 288 DRIEEKTRDGKDRGRDFERQREK-RDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHS 346
+R E+ R+ DRG++ ER+R++ R++ T +H RH Q+ +R
Sbjct: 2 ERQRERKRE-TDRGKETERERDRQRERENQTERENRHRQ--RDRHRERDRQTDREKERER 58
Query: 347 PSPR-RKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHER 405
R R+R +R R +RK+ R R R++ R
Sbjct: 59 QKERDRQRQRERETERETERQRERQ---------RQRERKRQTDRERDKDRDRERKRETD 109
Query: 406 TSQSHDRR--HERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARD 463
++ +R+ ER + T +RDRE++ + +RE E+ + R DRE + +R + +
Sbjct: 110 RNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 464 TRDRRELRDSRDMRDSREMRD 484
R + ++ ++ + + R+
Sbjct: 170 ERKKERKKERKEKKKEEKRRE 190
Score = 59.7 bits (143), Expect = 2e-08
Identities = 47/173 (27%), Positives = 77/173 (44%), Gaps = 12/173 (6%)
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK--RDREKDSREEREYEQDQS 441
R + RHR R+ R + DR+ +R +T + R RE+ + ER+ + D+
Sbjct: 36 RHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRE 95
Query: 442 SSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRST 501
+D DRE + DR R+ + RE RD + RE RD R+ + R+ R+ +
Sbjct: 96 RDKDR--DRERKRETDRNRERNRKGGRE----RDKQTERE-RDRERERQRQRE-RERQRQ 147
Query: 502 RDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
R+ DRE + +E+ E + R R+E + E R E + E
Sbjct: 148 RERKRETDRERQRWAEREERKKERKKE--RKKERKEKKKEEKRREDKKRKWGE 198
Score = 50.8 bits (120), Expect = 1e-05
Identities = 41/203 (20%), Positives = 90/203 (44%), Gaps = 21/203 (10%)
Query: 839 KRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ-GRWKEEDRKPE 897
+R+RE ++D + + ++ R + H DRQ R KE +R+ E
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 898 R-----------KESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDR 946
R +E+ R+ E Q +E+ D++R++ + R R D E
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDR--DRERKRETD----RNRERN 115
Query: 947 ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKK 1006
R D+ ++ + +++ ++++E + +R T + Q ++ ++ +KK E+K
Sbjct: 116 RKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK---ERK 172
Query: 1007 RKKSKGDSDISDEEAAQQSKKKR 1029
+++ K + EE ++ KK++
Sbjct: 173 KERKKERKEKKKEEKRREDKKRK 195
Score = 40.0 bits (92), Expect = 0.018
Identities = 35/162 (21%), Positives = 65/162 (40%), Gaps = 7/162 (4%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
R + R RER + ++ + E QK + E R RE++ + K +T
Sbjct: 33 RENRHRQRDRHRERDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQT 92
Query: 135 PESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194
+++ + E R+ N + N E + +R++ RE + Q E++ + K
Sbjct: 93 DRERDKDRDRERKRETDRNRERNRKGGRERDKQTERER-DRERERQRQRERERQRQRERK 151
Query: 195 KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
+E E R + R+ K ++K K KK+ K
Sbjct: 152 RETDRERQRW------AEREERKKERKKERKKERKEKKKEEK 187
Score = 39.7 bits (91), Expect = 0.023
Identities = 37/172 (21%), Positives = 72/172 (41%), Gaps = 18/172 (10%)
Query: 281 KEKYKVKDRIEEKTRDGKDRGRDFERQREK---RDKPRSTSPAGQHHSPISSRHHSSSSQ 337
+ +++ +DR E+ R DR ++ ERQ+E+ R + R T + R +
Sbjct: 34 ENRHRQRDRHRERDRQ-TDREKERERQKERDRQRQRERETERETERQR---ERQRQRERK 89
Query: 338 SGSSIQRHSPSPR-RKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMR 396
+ +R R RKR + +R R +R++ R R R
Sbjct: 90 RQTDRERDKDRDRERKRETDRNRERNRKGGRERD---------KQTERERDRERERQRQR 140
Query: 397 EKGRHDHERTSQSHDRRHER-REDTRGKRDREKDSREEREYEQDQSSSRDHR 447
E+ R + DR +R E K++R+K+ ++ER+ ++ + R+ +
Sbjct: 141 ERERQRQRERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDK 192
Score = 37.7 bits (86), Expect = 0.088
Identities = 28/158 (17%), Positives = 63/158 (39%), Gaps = 14/158 (8%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R ER R+R + + ++ + E +++ + ++++ R R ++++ + K T
Sbjct: 52 REKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRD--RERKRETD 109
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
+ E N + RD + + + + E +RQ+ + + ++E E KK
Sbjct: 110 RNRERNRKGGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKK 169
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK 233
E E RK + K+K + +K
Sbjct: 170 ERKKE------------RKKERKEKKKEEKRREDKKRK 195
Score = 33.1 bits (74), Expect = 2.2
Identities = 43/206 (20%), Positives = 84/206 (40%), Gaps = 45/206 (21%)
Query: 113 RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQK 172
++E+ RG+ E+E + +ER ++E EN + +R + + + E E RQ+
Sbjct: 8 KRETDRGKETERERDR-QRERENQTERENRHRQRDRHRERDRQTDREKERERQKERDRQR 66
Query: 173 IQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASK 232
QRE + E+E +RE R+ + KR++ +
Sbjct: 67 -QRE-RETERETERQRE-----------------------RQRQRERKRQTDRERDKDRD 101
Query: 233 KDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEE 292
++RK + ++RN K + + K + +E+ + ++R +
Sbjct: 102 RERKRETDRN----RERNRKGGRERDKQTERER------------DRERERQRQRERERQ 145
Query: 293 KTRDGK---DRGRDFERQREKRDKPR 315
+ R+ K DR R +RE+R K R
Sbjct: 146 RQRERKRETDRERQRWAEREERKKER 171
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 166 bits (421), Expect = 1e-40
Identities = 88/184 (47%), Positives = 133/184 (72%), Gaps = 16/184 (8%)
Query: 628 ERDRRDNRERDQRPSSPIRHQGRNDELERD---ERREERRVDRVDDRRDERARERDRERE 684
ER+R+ RER QR + RH+ ++ E+E+D +R+ +R R DR +R R DR+RE
Sbjct: 59 ERERQRERER-QRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRE 117
Query: 685 RDRERERERERERDREREKERELERERA----REREREREKERDRERD-------RDRDH 733
+ ER+ ERER+RDR+REK+RE +R+R ++RE E EK+RDRER+ RDR+
Sbjct: 118 TETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRER 177
Query: 734 DRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDK 793
+R+++RE RDR++ER+RE+E+RER+R+R++ERE++R RERE R+RDKER+R+R +K
Sbjct: 178 ERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQ-REK 236
Query: 794 DKGR 797
D+ R
Sbjct: 237 DRDR 240
Score = 154 bits (390), Expect = 5e-37
Identities = 77/178 (43%), Positives = 123/178 (69%), Gaps = 6/178 (3%)
Query: 658 ERREERRVDRVDDRRDERARERDRE--RERDRERERERERERDREREKERELERERARER 715
ER +R +R R ER RE+DRE ++RDR+R+R+RER+R R+R+++RE +R RE
Sbjct: 59 ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118
Query: 716 EREREKERDRERDRDRDHDRERERERE----RDREKEREREREERERERERERERERERE 771
E ER++ER+R+RDR R+ DRER+R+RE +DRE E E++R+ E ER R+RERE
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178
Query: 772 RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
R+++R RD++RERQR+ ED+++ RD ++E+ ++ +R D+ + ++R R +
Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREK 236
Score = 146 bits (369), Expect = 1e-34
Identities = 81/203 (39%), Positives = 132/203 (65%), Gaps = 5/203 (2%)
Query: 661 EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE 720
E+R V + R A R+RER+R+RER+R+R +ER RE+++E E +R+R R+R+RER+
Sbjct: 40 EDRDVLILRGSRVAPAIIRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQ 99
Query: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
+ RDR+R R+R DR+RE E ER E+ER+R +R+RE++RER+R+RE +++R E
Sbjct: 100 RWRDRDRKRERWGDRDRETETERQEERERQR---DRKREKDRERQRQREIGIDKDREIET 156
Query: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK- 839
+K+R+R+R+ + ++ RD RE++++ RE R RD +R+ + R R+ R+ +
Sbjct: 157 EKDRDREREMGETERYRDRERERQKQ-RETRRDRDRERQREKEDRERDRDRQKEREKDRY 215
Query: 840 RRREHSPDSDAYNSGDDKNEKHR 862
R RE D D + + EK R
Sbjct: 216 RERETGRDRDKERDRERQREKDR 238
Score = 108 bits (270), Expect = 4e-23
Identities = 70/206 (33%), Positives = 103/206 (50%), Gaps = 21/206 (10%)
Query: 543 IRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSY 602
IR R R R R R + E+ + R + W R
Sbjct: 57 IRERERQRERERQRKRAKERHREKDREIEKDRDRQRK---------RDRERQRWRDRDR- 106
Query: 603 PERDRYPERDNRDQARDSSFERRHGERDRRDNRERD-QRPSSPIRHQGRNDELERDERRE 661
+R+R+ +RD + R +R R +RER QR + + E +RD RE
Sbjct: 107 -KRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRERE 165
Query: 662 ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREK 721
+R DR ER ++R+ R+RDRER+RE+E DRER+++R+ ERE+ R RERE +
Sbjct: 166 MGETERYRDRERERQKQRETRRDRDRERQREKE---DRERDRDRQKEREKDRYRERETGR 222
Query: 722 ERDRERDRDRDHDRERERERERDREK 747
+RD+ER DRER+RE++RDR+K
Sbjct: 223 DRDKER------DRERQREKDRDRQK 242
Score = 97.4 bits (241), Expect = 9e-20
Identities = 58/206 (28%), Positives = 115/206 (55%), Gaps = 20/206 (9%)
Query: 737 RERERERDREKERERERE-ERERERERERERERERERERERARERDKERERQRDWEDKDK 795
RERER+R+RE++R+R +E RE++RE E++R+R+R+R+RER R RD++R+R+R W D+D+
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRER-WGDRDR 116
Query: 796 GRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGD 855
+ R++ E + DR + ++ ++ ++ + + R +++ Y +
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRE 176
Query: 856 DKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQEL---KE 912
+ +K R E+R +++ R ++ DR+ ER++ RY E+E ++
Sbjct: 177 RERQKQR---------ETRRDRDRERQREKEDRERDRDRQKEREKD--RYRERETGRDRD 225
Query: 913 KVSSVDKQREQTEILESSRMRAQDII 938
K ++QRE+ + R +A D +
Sbjct: 226 KERDRERQREK----DRDRQKAIDCV 247
Score = 81.3 bits (199), Expect = 7e-15
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 13/177 (7%)
Query: 1281 ESDRQVHSRSGSFDSRDRLQERDR-YEHDRERERERRDTRQREWDRDADKD-W-PRNRDR 1337
E +RQ +++R +E+DR E DR+R+R+R RQR DRD ++ W R+R+
Sbjct: 59 ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118
Query: 1338 DRLRERERERERDKRRDLDRERERLISDSVERDR----DRDRDRTFESSQIESVKRCEAK 1393
+ R+ ERER+RD++R+ DRER+R +++DR ++DRDR E + E +
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYR----- 173
Query: 1394 LEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDD 1450
+ E ER + +R +++R +D + ++ + +R E G D K D
Sbjct: 174 -DRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229
Score = 80.5 bits (197), Expect = 1e-14
Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 37/193 (19%)
Query: 1216 RSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKR------------GEPSRST 1263
R + + RKR + R REK + +E +R+ + D+ ++ G+ R T
Sbjct: 62 RQRERERQRKR---AKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118
Query: 1264 SSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS-------RDRLQERDRYEHDRERERERR 1316
++RQ+ R R + + R D +DR +ER+ E +R R+RER
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERE 178
Query: 1317 DTRQREWDRDADKDWPRN-----RDRDRLRERE----RERERDKRRDLDRERERLISDSV 1367
+QRE RD D++ R RDRDR +ERE RERE + RD +R+RER
Sbjct: 179 RQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRER------ 232
Query: 1368 ERDRDRDRDRTFE 1380
+R++DRDR + +
Sbjct: 233 QREKDRDRQKAID 245
Score = 77.0 bits (188), Expect = 1e-13
Identities = 63/195 (32%), Positives = 94/195 (48%), Gaps = 21/195 (10%)
Query: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQ 1285
RV + R+RE+ + E R+ + + + E R DR R R +
Sbjct: 51 RVAPAIIRERERQRERE----RQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDR 106
Query: 1286 VHSRSGSFDSR---DRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRE 1342
R G D +R +ER+R + DR+RE++R RQRE D D++ +DRDR RE
Sbjct: 107 KRERWGDRDRETETERQEERER-QRDRKREKDRERQRQREIGIDKDREIETEKDRDRERE 165
Query: 1343 R-ERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
E ER RD+ R+ ++RE RDRDR+R R E + + ++ E + + ER+
Sbjct: 166 MGETERYRDRERERQKQRE------TRRDRDRERQREKEDRERDRDRQKEREKDRYRERE 219
Query: 1402 LESTSRDSLALDKER 1416
T RD DKER
Sbjct: 220 ---TGRDR---DKER 228
Score = 73.9 bits (180), Expect = 1e-12
Identities = 63/237 (26%), Positives = 113/237 (47%), Gaps = 62/237 (26%)
Query: 743 RDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802
R+RE++RERER+ R+R +ER RE++RE E++R+R R+RD+ER+R RD RD +RE
Sbjct: 58 RERERQRERERQ-RKRAKERHREKDREIEKDRDRQRKRDRERQRWRD-------RDRKRE 109
Query: 803 KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
+ + DR E + ++R R RQ R+RE D D + ++ R
Sbjct: 110 RWGD--RDRETETERQEERERQRDRKREKDRERQ---RQREIGIDKDREIETEKDRDRER 164
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQRE 922
+ + TE R+++ +R+ +++ +RR ++E +QRE
Sbjct: 165 EMGE---------------TE----RYRDRERERQKQRETRRDRDRE---------RQRE 196
Query: 923 QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIER 979
+ EDRE DR + ++K + +++ + ++ + ER
Sbjct: 197 K--------------------EDRE-RDRDRQKEREKDRYRERETGRDRDKERDRER 232
Score = 69.3 bits (168), Expect = 3e-11
Identities = 45/184 (24%), Positives = 79/184 (42%), Gaps = 16/184 (8%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
+R++ R R R K RH + DR +R+ D +R R++D + ER ++D+ +
Sbjct: 59 ERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRET 118
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
+ +++RE + R R R+ + +RE+ +D R+ + +D R
Sbjct: 119 ETERQEERERQRDRKREKDRERQRQREIGIDKD-----------REIETEKDRDREREMG 167
Query: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
+ YRDRE R+ E R R RE+ R R+ + + R GR
Sbjct: 168 ETERYRDRE-----RERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGR 222
Query: 563 SRGR 566
R +
Sbjct: 223 DRDK 226
Score = 67.4 bits (163), Expect = 1e-10
Identities = 50/170 (29%), Positives = 80/170 (47%), Gaps = 17/170 (10%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR--------EKDSREER 434
QRK++ RHR RE + D +R + DR +R D KR+R E + +EER
Sbjct: 69 QRKRAKERHREKDREIEK-DRDR-QRKRDRERQRWRDRDRKRERWGDRDRETETERQEER 126
Query: 435 EYEQDQSSSRDHRDDREPRDGRDR-RDARDTRDR---RELRDSRDMRDSREMRDYSRDTK 490
E ++D+ +D R+ G D+ R+ +DR RE+ ++ RD R R+T+
Sbjct: 127 ERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETR 186
Query: 491 ESRDPRDSRSTRDAHDYRDRE---GRDTHRKEDTYPEESRSYGRNHLREE 537
RD R D RDR+ +D +R+ +T + + R RE+
Sbjct: 187 RDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREK 236
Score = 63.2 bits (152), Expect = 2e-09
Identities = 62/218 (28%), Positives = 89/218 (40%), Gaps = 41/218 (18%)
Query: 426 REKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDY 485
RE++ + ERE ++ ++ R DRE RDR+ RD R+R+ RD R+ RD
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRD-RERQRWRDRDRKRERWGDRDR 116
Query: 486 SRDTKESRD---PRDSRSTRDAHDYRDRE-GRDTHRKEDTYPEESRSYGRNHLREESSRT 541
+T+ + RD + +D R RE G D R+ +T + R E T
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDRE-------REMGET 169
Query: 542 EIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSS 601
E R R R + R R R R R E ++ + R
Sbjct: 170 E-RYRDRERERQKQRETRRDRDRERQREKEDR--------------------ERDRDRQK 208
Query: 602 YPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQ 639
E+DRY ER+ RD R ERDR RE+D+
Sbjct: 209 EREKDRYRERET---GRD-----RDKERDRERQREKDR 238
Score = 59.7 bits (143), Expect = 2e-08
Identities = 67/221 (30%), Positives = 93/221 (42%), Gaps = 46/221 (20%)
Query: 278 KKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQ 337
K+ KE+++ KDR EK RD + R RD ERQR RD+ R G R + Q
Sbjct: 71 KRAKERHREKDREIEKDRD-RQRKRDRERQRW-RDRDRKRERWGDR-----DRETETERQ 123
Query: 338 SGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMRE 397
QR RKR QR QR+ + R E
Sbjct: 124 EERERQRD-----RKREKDRERQR---------------------QREIGIDKDREIETE 157
Query: 398 KGRHDHER----TSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPR 453
K R D ER T + DR ER++ +RDR+++ + E+E D+ RD + +RE
Sbjct: 158 KDR-DREREMGETERYRDRERERQKQRETRRDRDRERQREKE---DRERDRDRQKERE-- 211
Query: 454 DGRDRRDARDT-RDRRELRDSRDMRDSREMRDYSRDTKESR 493
+DR R+T RDR + RD R+ R + D R
Sbjct: 212 --KDRYRERETGRDRDKERDRERQREKDRDRQKAIDCVPGR 250
Score = 58.9 bits (141), Expect = 4e-08
Identities = 62/259 (23%), Positives = 100/259 (38%), Gaps = 83/259 (32%)
Query: 758 RERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGH 817
RERER+RERER+R+R +ER RE+D+E E+ R DR+ KR+ R+ RD
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDR----------DRQRKRDRERQRWRDRD-- 105
Query: 818 DERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS 877
R+RE D D
Sbjct: 106 ----------------------RKRERWGDRDRETE------------------------ 119
Query: 878 PSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQRE---------QTEILE 928
TE ++ R ++ DRK E+ +R E +DK RE + E+ E
Sbjct: 120 ----TERQEERERQRDRKREKDRERQRQRE-------IGIDKDREIETEKDRDREREMGE 168
Query: 929 SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSED 988
+ R R ++ Q E R DR K+ + + K++++D R T D
Sbjct: 169 TERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKD-----RYRERETGRD 223
Query: 989 GQVFSPKKGQKKKSIEKKR 1007
++ Q++K ++++
Sbjct: 224 RDKERDRERQREKDRDRQK 242
Score = 53.5 bits (127), Expect = 2e-06
Identities = 36/135 (26%), Positives = 64/135 (47%), Gaps = 3/135 (2%)
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRD- 448
R R++ R + DR +R+ + +DRE ++ ++R+ E++ + +RD
Sbjct: 116 RETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDR 175
Query: 449 DREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR 508
+RE + R+ R RD +RE D RD ++ R+ R +E RD RD R
Sbjct: 176 ERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDR-YRERETGRDRDKERDRERQR 234
Query: 509 DREGRDTHRKEDTYP 523
+++ RD + D P
Sbjct: 235 EKD-RDRQKAIDCVP 248
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/154 (29%), Positives = 64/154 (41%), Gaps = 28/154 (18%)
Query: 383 QRKQSPPRHRSPMREKGRH---DHER-TSQSHDRRHERREDTRGKRDRE----------- 427
QRK+ R R R++ R D +R T ER+ D + ++DRE
Sbjct: 91 QRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQRDRKREKDRERQRQREIGIDK 150
Query: 428 -------KDSREEREY---EQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR 477
KD ERE E+ + R+ + RE R RDR R+ DR RD + R
Sbjct: 151 DREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKER 210
Query: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE 511
+ R+ R+T RD R + D RDR+
Sbjct: 211 EKDRYRE--RETGRDRDKERDRERQREKD-RDRQ 241
Score = 38.5 bits (88), Expect = 0.051
Identities = 47/215 (21%), Positives = 92/215 (42%), Gaps = 29/215 (13%)
Query: 890 KEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQ---SEDR 946
+E +R+ ER+ +R +E+ +EK ++K R++ + R R +D + DR
Sbjct: 58 RERERQRERERQRKRAKERH-REKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDR 116
Query: 947 ETS-----------DRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSE-----DGQ 990
ET DR ++++++ + ++ I K +E + +R E D +
Sbjct: 117 ETETERQEERERQRDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRE 176
Query: 991 VFSPKKGQKKKSIEKKRKKSKGDSDIS-DEEAAQQSKKKRGPRTPPITTKEELVEMCNGK 1049
K+ + ++ +++R++ K D + D + ++ + R T KE E K
Sbjct: 177 RERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREK 236
Query: 1050 NGILEDSQKKEDTAFSDW-----SDEDVPDRTEVT 1079
+ D QK D W + + VP R EVT
Sbjct: 237 D---RDRQKAIDCVPGRWEVTVMAVDCVPGRWEVT 268
Score = 36.6 bits (83), Expect = 0.20
Identities = 47/236 (19%), Positives = 93/236 (39%), Gaps = 53/236 (22%)
Query: 85 LRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRG--RHREKEDIKITKERTPESEEENV 142
+RER + + ++ + K E + K+ R R RE++ + + + +
Sbjct: 57 IRERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDR 116
Query: 143 EWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVV 202
E ET R + E + KR+K RE + + ++K EI +K+ E
Sbjct: 117 ETETERQEE----------RERQRDRKREK-DRERQRQREIGIDKDREIETEKDRDRE-- 163
Query: 203 RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPR 262
R+ ++ + + + ++ R+ D+ R + + ++ R
Sbjct: 164 ----------REMGETERYRDRERERQKQRETRR---------DRDRERQREKEDRERDR 204
Query: 263 TPSPPPPIPEDIALGKKYKEKYKVKDRIEEK-TRDGKDRGRDFERQREK-RDKPRS 316
++K + KDR E+ T +D+ RD ERQREK RD+ ++
Sbjct: 205 D-----------------RQKEREKDRYRERETGRDRDKERDRERQREKDRDRQKA 243
Score = 34.7 bits (78), Expect = 0.74
Identities = 27/100 (27%), Positives = 42/100 (42%), Gaps = 10/100 (10%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTE---------ESSSPVRKES 116
R + + R +R G ++R +D D E + TE + R++
Sbjct: 130 RDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDR 189
Query: 117 SRGRHREKEDIKITKERTPESEEENV-EWETNRDDSDNGD 155
R R REKED + ++R E E++ E ET RD D
Sbjct: 190 DRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERD 229
Score = 33.5 bits (75), Expect = 1.7
Identities = 33/126 (26%), Positives = 49/126 (38%), Gaps = 19/126 (15%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE--------- 125
+R ER R+R + + D D E + EE +E R R REK+
Sbjct: 93 KRDRERQRWRDRDRKRERWGDRDRETETERQEE------RERQRDRKREKDRERQRQREI 146
Query: 126 ----DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLE 181
D +I E+ + E E E E RD + + E +R+K RE +
Sbjct: 147 GIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDR 206
Query: 182 QENMEK 187
Q+ EK
Sbjct: 207 QKEREK 212
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 158 bits (399), Expect = 4e-38
Identities = 104/354 (29%), Positives = 180/354 (50%), Gaps = 42/354 (11%)
Query: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642
I+ S SN +RS + R + + + R S R R ++ +R
Sbjct: 293 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 352
Query: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE 702
SP + + ++ E + R R R D R + +ER +E++R++ERERE+ERE+
Sbjct: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK----- 407
Query: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
E+ER + ++R++E+E+DRE+D+++D +RERE+E E+DR+KE+E+E +++E+ERE+
Sbjct: 408 -----EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE-QDKEKEREK 461
Query: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
+R +E + +R++++ K R R + + R RE+R R+S
Sbjct: 462 DRSKEIDEKRKKDK-----KSRTPPRSYNASRRSRSSSRERR--------------RRRS 502
Query: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR-LLSQVVRPQESRSLSPSHL 881
+ R SP ++ KR+ SP + N D K EK R +S+ R + RS S
Sbjct: 503 RSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE--RRERERSTSMRKS 557
Query: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
+ DR G+ K E K S+ E++ KE SSV K+ + + + + Q
Sbjct: 558 SNDRDGKEKLE------KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 605
Score = 130 bits (326), Expect = 1e-29
Identities = 91/331 (27%), Positives = 165/331 (49%), Gaps = 26/331 (7%)
Query: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
++R+ R+R R + R + R R+R + + + R R R+R+++R R K ++R
Sbjct: 301 NERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRS 359
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE------RDK 782
+ R+ R + R R R+K ++ + +E+ER +E++RE+ERERE+ER +E +D+
Sbjct: 360 KSRE--RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 417
Query: 783 ERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR 842
++ER++D +KDK +D RE+ +E +DR+ ++ K K+R ++ + K ++
Sbjct: 418 DKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 476
Query: 843 EHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESS 902
+P +YN+ + + R S+ R + SRS S S T K RK R S
Sbjct: 477 SRTPPR-SYNA----SRRSRSSSRERRRRRSRSSSRSPRTS------KTIKRKSSRSPSP 525
Query: 903 R-RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961
R R ++ + +EK +R + E S R + D G + E TS + + NK+
Sbjct: 526 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 585
Query: 962 IQKKPIKKK----KEDDVGIERGNIETTSED 988
K + K E++ GN + E+
Sbjct: 586 SVSKEVDDKDAPRTEENKIQHNGNCQLNEEN 616
Score = 123 bits (309), Expect = 1e-27
Identities = 92/360 (25%), Positives = 175/360 (48%), Gaps = 37/360 (10%)
Query: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
++E+ + + +E++ + ++ +R+G R +SRS ++H R +
Sbjct: 272 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGG---RSRSHTRSKSRSSSKSHSRRKR 328
Query: 539 SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
S+++ R+ S N SRS ++ R R + P SR R S+ SHS + +T
Sbjct: 329 SQSKHRSRSHNRSRSRQKD----RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----DT 380
Query: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE 658
R E++R E+D R++ R+ ER E++R N++RD+ E E+D
Sbjct: 381 REKIKEKERVKEKD-REKEREREKEREK-EKERGKNKDRDK-------------EREKD- 424
Query: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERA------ 712
R +++ DR +R E ++RD+E+E+++++E+ERE++R +E +++R+ +++
Sbjct: 425 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 484
Query: 713 REREREREKERDRERDRDRDHDRERERERERDREKERE---REREERERERERERERERE 769
R R R+R R R R R + R+ R R R +++++RE+ER+ E
Sbjct: 485 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 544
Query: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
R RERER+ K + E +K +EK D + D++ + + N+
Sbjct: 545 R-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 603
Score = 98.2 bits (243), Expect = 5e-20
Identities = 76/318 (23%), Positives = 135/318 (42%), Gaps = 27/318 (8%)
Query: 675 RARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734
+A ++ E R RE + E E + ER+ R R R K R + R
Sbjct: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR--- 325
Query: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW---- 790
R+R + + R R R R R+ ++R R + ++R + RER ++R R R++++D
Sbjct: 326 RKRSQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 384
Query: 791 ------EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREH 844
++KD+ ++ REK E ++R D+ + K R +++ R+ R +EH
Sbjct: 385 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKEH 441
Query: 845 SPDSDAYNSGDDKNEKHRLLSQVVRPQESRS------LSPSHLTEDRQGRWKEEDRKPER 898
D D + EK R + E R P R+ R +R+ R
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501
Query: 899 KESSRR--YEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-AHDE 955
SS R + +K K S R + + + R + +D I + +R TS R + ++
Sbjct: 502 SRSSSRSPRTSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSND 560
Query: 956 NKKKAKIQKKPIKKKKED 973
K K++K K+++
Sbjct: 561 RDGKEKLEKNSTSLKEKE 578
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/263 (29%), Positives = 132/263 (50%), Gaps = 28/263 (10%)
Query: 1196 RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLK 1255
R +S S + S S R G GR R S R K++S + R+ R
Sbjct: 283 REAQSFISAAIEPESGKSNERKG----GRSR-----SHTRSKSRSSSKSHSRRKRSQSKH 333
Query: 1256 RGEP---SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERE 1312
R SRS DR+ S+S +RS R+ SRS S D R +E+ + E +R +E
Sbjct: 334 RSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK-EKERVKE 392
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD 1372
++R R+RE +R+ +K+ +N+DRD+ ERE++RE+DK +D +RERE+ E+DRD
Sbjct: 393 KDREKEREREKEREKEKERGKNKDRDK--EREKDREKDKEKDREREREK----EHEKDRD 446
Query: 1373 RDRDRTFESSQIESVKRCEAKLEGEHERDLES--------TSRDSLALDKERMDKDLGSV 1424
+++++ + + E K +++ + ++D +S SR S + +ER + S
Sbjct: 447 KEKEKE-QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 505
Query: 1425 QGFEETNKSERTESLEAGDDESK 1447
T+K+ + +S + S+
Sbjct: 506 SRSPRTSKTIKRKSSRSPSPRSR 528
Score = 94.4 bits (233), Expect = 8e-19
Identities = 81/321 (25%), Positives = 132/321 (41%), Gaps = 39/321 (12%)
Query: 266 PPPPIPEDIALGKKYKEKYKVKDRIEE---------KTRDGKDRGRDFERQREK-RDKPR 315
PP P+ A KE +V R+ E + GK R R R R K R
Sbjct: 263 PPEMTPQAAA-----KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 317
Query: 316 STSPAGQHHSPISSRHHSSS---SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
S+S + S+H S S S+S +R S SP +KR+ S +++ + R
Sbjct: 318 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377
Query: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432
+ +R + R + REK R + ++ DR ER ++DREKD +
Sbjct: 378 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER------EKDREKDKEK 431
Query: 433 ------EREYEQDQSSSRDHRDDREPRDGRDRR---DARDTRDRRELRDSRDMRDSREMR 483
E+E+E+D+ ++ D+E +DR D + +D++ R SR R
Sbjct: 432 DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSR 491
Query: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEI 543
SR+ + R SRS R + + + R + ++ R R+H+ E
Sbjct: 492 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER------ 545
Query: 544 RNESRNESRSEIRNDRMGRSR 564
R R+ S + NDR G+ +
Sbjct: 546 RERERSTSMRKSSNDRDGKEK 566
Score = 90.5 bits (223), Expect = 1e-17
Identities = 80/347 (23%), Positives = 155/347 (44%), Gaps = 47/347 (13%)
Query: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS-SPQRKQSPPRHR 392
S+ + G + H+ S + R+ S S+ R +RS S + S S + S R++ R +
Sbjct: 300 SNERKGGRSRSHTRS--KSRSSSKSHSRR-----KRSQSKHRSRSHNRSRSRQKDRRRSK 352
Query: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGK-RDREKDSREEREYEQDQSSSRDHRDDRE 451
SP +++ + R S+S ++R+DTR K +++E+ ++RE E+++ R+ +R
Sbjct: 353 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 412
Query: 452 PRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE 511
RD+ +D R++ + +D R+ +D ++ ++ +D R + + ++
Sbjct: 413 KNKDRDKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 471
Query: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP 571
+D +K T P RSY + SSR R SR+ SRS + + R R P
Sbjct: 472 KKD--KKSRTPP---RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526
Query: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR 631
+ + + + ERD ER R++ R +S + +RD
Sbjct: 527 SRNKKDKKREK---------------------ERDHISER--RERERSTSMRKSSNDRDG 563
Query: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARE 678
++ E++ S+ ++ + N E + +E VDD+ R E
Sbjct: 564 KEKLEKN---STSLKEKEHNKEPDSSVSKE------VDDKDAPRTEE 601
Score = 80.9 bits (198), Expect = 9e-15
Identities = 85/343 (24%), Positives = 138/343 (40%), Gaps = 44/343 (12%)
Query: 406 TSQSHDRRHER-REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDT 464
+ +S++R+ R R TR K S R+ Q + SR H R +
Sbjct: 297 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQ----------- 345
Query: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPR-DSRSTRDAHDYRDREGRDTHRKEDTYP 523
+DRR + R R SR SRD R D+R + + R+ R+ +
Sbjct: 346 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 405
Query: 524 EESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPEL---PEKGSRGSRG 580
E+ + G+N R++ R + R + + + R R + R + E EK R
Sbjct: 406 EKEKERGKNKDRDK-EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 464
Query: 581 SQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR 640
+ID + +S P R R ++R SS ERR R R + R R
Sbjct: 465 KEIDEKRKK-------DKKSRTPPRSYNASR----RSRSSSRERR---RRRSRSSSRSPR 510
Query: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERE-RERDR 699
S I+ + R +++++ R +ERD ER RERER R+
Sbjct: 511 TSKTIKRKSSRSPSPRSRNKKDKK----------REKERDHISER-RERERSTSMRKSSN 559
Query: 700 EREKERELERERAREREREREKERDRERDRDRDHDRERERERE 742
+R+ + +LE+ +E+E KE D ++ D D++ R E
Sbjct: 560 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD-DKDAPRTEE 601
Score = 80.5 bits (197), Expect = 1e-14
Identities = 71/293 (24%), Positives = 126/293 (43%), Gaps = 48/293 (16%)
Query: 1198 NRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRG 1257
+RSHT + RS S + R R R H+ SR R+K + + +K + +R
Sbjct: 308 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDRRRSKSPHKKRSKSRERRK 366
Query: 1258 EPSRSTSSD-RQDSRSHSSRRS-----------SPESDRQVHSRSGSFDSRDRLQERDRY 1305
SRS S D R+D+R + E +R+ G RD+ +E+DR
Sbjct: 367 SRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDR- 425
Query: 1306 EHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERE------------------- 1346
E D+E++RER ++ E DRD +K+ ++++++R ++R +E
Sbjct: 426 EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN 485
Query: 1347 ---------RERDKRRDLDRERERLISDSVERDRDRD---RDRTFESSQIESVK-RCEAK 1393
RER +RR R S +++R R R R + + E + +
Sbjct: 486 ASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER 545
Query: 1394 LEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDES 1446
E E + +S D KE+++K+ S++ E + + + S E D ++
Sbjct: 546 RERERSTSMRKSSNDRDG--KEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 596
Score = 77.0 bits (188), Expect = 1e-13
Identities = 87/339 (25%), Positives = 139/339 (41%), Gaps = 41/339 (12%)
Query: 207 SPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSP 266
S S S RK S+S R S S + +KDR+ S SP ++ SK+ + +K R+ S
Sbjct: 320 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS--KSP---HKKRSKSRERRKSRSRSHSR 374
Query: 267 PP--PIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323
E I ++ KEK + K+R EK R+ K+RG++ +R +E R+K R
Sbjct: 375 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDR 433
Query: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQ 383
H + Q + R+ +R + S P S ++ +
Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK-----KDKKSRTPPRSYNASR 488
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
R +S R R R + RTS++ R+ R R + +KD + E+E
Sbjct: 489 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR--NKKDKKREKE-------- 538
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
RDH +R R+ R T R+ D RD ++ E S KE DS +++
Sbjct: 539 RDHISERRERE-------RSTSMRKSSND-RDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 590
Query: 504 AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542
D +D R E+ + + G L EE+ T+
Sbjct: 591 VDD------KDAPRTEENKIQHN---GNCQLNEENLSTK 620
Score = 63.5 bits (153), Expect = 1e-09
Identities = 76/289 (26%), Positives = 126/289 (43%), Gaps = 24/289 (8%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
+ K S ++ RS R R + +K++ E +K + S RK++ R + +EKE
Sbjct: 330 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKE 388
Query: 126 DIKIT-KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN 184
+K +E+ E E+E E E R + + D + E E R +RE K +++
Sbjct: 389 RVKEKDREKEREREKER-EKEKERGKNKDRDKEREKDREKDKEKDR---EREREKEHEKD 444
Query: 185 MEKREEIIIKKEVSPEVVRSK-LSPSPSLRKSSKSPKR--KSSPKSSSASKKDRKTSAVS 241
+K +E KE E RSK + K S++P R +S +S S+S++ R+ + S
Sbjct: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 504
Query: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG 301
S R SKT K+K R+PSP + KK K++ K +D I E+ ++R
Sbjct: 505 SS--RSPRTSKT--IKRKSSRSPSPR-------SRNKKDKKREKERDHISER----RERE 549
Query: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR 350
R ++ D+ S H+ S S +PR
Sbjct: 550 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 598
Score = 57.0 bits (136), Expect = 1e-07
Identities = 81/355 (22%), Positives = 133/355 (37%), Gaps = 55/355 (15%)
Query: 747 KEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREE 806
K E + +E E +R RE + A E + + +R KG R R +
Sbjct: 262 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNER------KGGRSRSHTRSK 315
Query: 807 IREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQ 866
R +SK R R+ RQ RRR SP S + + + R S+
Sbjct: 316 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKD-RRRSKSPHKKRSKSRERRKSRSRSHSR 374
Query: 867 VVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEI 926
R + R KE+DR+ ER+ R +E+E + K DK+RE+
Sbjct: 375 DKRKDTREKIKEKE-------RVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKD-- 424
Query: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
+ +D+E DR + K+ K + K +K+KE D ER +
Sbjct: 425 ---------------REKDKE-KDREREREKEHEKDRDK--EKEKEQDKEKEREKDRSKE 466
Query: 987 EDGQVFSPKKGQ------------KKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTP 1034
D + KK + + S E++R++S+ S + K R P
Sbjct: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526
Query: 1035 PITTKEELVEMCNGKNGILEDSQKKEDTAFSDWS-DEDVPDR-----TEVTEAEH 1083
K++ E ++ I E +++ T+ S D D ++ T + E EH
Sbjct: 527 SRNKKDKKRE--KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
Score = 42.0 bits (97), Expect = 0.005
Identities = 46/242 (19%), Positives = 87/242 (35%), Gaps = 39/242 (16%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
R K R + RE+ + K ++ D E ++ E KE + + +E+E
Sbjct: 401 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 460
Query: 126 DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENM 185
K+R+ E +E+ + + +R + R +E
Sbjct: 461 -----KDRSKEIDEKRKKDKKSRTPP-----------------RSYNASRRSRSSSRERR 498
Query: 186 EKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL 245
+R + + + ++ K S SPS R +K K++ + + +++R+ S
Sbjct: 499 RRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST------ 552
Query: 246 DQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFE 305
+++S K+K E + K KE K D K D KD R E
Sbjct: 553 SMRKSSNDRDGKEK-----------LEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 601
Query: 306 RQ 307
+
Sbjct: 602 NK 603
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 158 bits (399), Expect = 4e-38
Identities = 104/354 (29%), Positives = 180/354 (50%), Gaps = 42/354 (11%)
Query: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642
I+ S SN +RS + R + + + R S R R ++ +R
Sbjct: 177 IEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSK 236
Query: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE 702
SP + + ++ E + R R R D R + +ER +E++R++ERERE+ERE+
Sbjct: 237 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREK----- 291
Query: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
E+ER + ++R++E+E+DRE+D+++D +RERE+E E+DR+KE+E+E +++E+ERE+
Sbjct: 292 -----EKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKE-QDKEKEREK 345
Query: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
+R +E + +R++++ K R R + + R RE+R R+S
Sbjct: 346 DRSKEIDEKRKKDK-----KSRTPPRSYNASRRSRSSSRERR--------------RRRS 386
Query: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR-LLSQVVRPQESRSLSPSHL 881
+ R SP ++ KR+ SP + N D K EK R +S+ R + RS S
Sbjct: 387 RSSSR---SPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE--RRERERSTSMRKS 441
Query: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
+ DR G+ K E K S+ E++ KE SSV K+ + + + + Q
Sbjct: 442 SNDRDGKEKLE------KNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQ 489
Score = 130 bits (326), Expect = 1e-29
Identities = 91/331 (27%), Positives = 165/331 (49%), Gaps = 26/331 (7%)
Query: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
++R+ R+R R + R + R R+R + + + R R R+R+++R R K ++R
Sbjct: 185 NERKGGRSRSHTRSKSRSSSKSHSR-RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRS 243
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARE------RDK 782
+ R+ R + R R R+K ++ + +E+ER +E++RE+ERERE+ER +E +D+
Sbjct: 244 KSRE--RRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDR 301
Query: 783 ERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR 842
++ER++D +KDK +D RE+ +E +DR+ ++ K K+R ++ + K ++
Sbjct: 302 DKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKK 360
Query: 843 EHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESS 902
+P +YN+ + + R S+ R + SRS S S T K RK R S
Sbjct: 361 SRTPPR-SYNA----SRRSRSSSRERRRRRSRSSSRSPRTS------KTIKRKSSRSPSP 409
Query: 903 R-RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961
R R ++ + +EK +R + E S R + D G + E TS + + NK+
Sbjct: 410 RSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDS 469
Query: 962 IQKKPIKKK----KEDDVGIERGNIETTSED 988
K + K E++ GN + E+
Sbjct: 470 SVSKEVDDKDAPRTEENKIQHNGNCQLNEEN 500
Score = 123 bits (309), Expect = 1e-27
Identities = 92/360 (25%), Positives = 175/360 (48%), Gaps = 37/360 (10%)
Query: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
++E+ + + +E++ + ++ +R+G R +SRS ++H R +
Sbjct: 156 AKELEEVMKRVREAQSFISAAIEPESGKSNERKGG---RSRSHTRSKSRSSSKSHSRRKR 212
Query: 539 SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWET 598
S+++ R+ S N SRS ++ R R + P SR R S+ SHS + +T
Sbjct: 213 SQSKHRSRSHNRSRSRQKD----RRRSKSPHKKRSKSRERRKSRSRSHSRDKRK----DT 264
Query: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE 658
R E++R E+D R++ R+ ER E++R N++RD+ E E+D
Sbjct: 265 REKIKEKERVKEKD-REKEREREKEREK-EKERGKNKDRDK-------------EREKD- 308
Query: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERA------ 712
R +++ DR +R E ++RD+E+E+++++E+ERE++R +E +++R+ +++
Sbjct: 309 REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSY 368
Query: 713 REREREREKERDRERDRDRDHDRERERERERDREKERE---REREERERERERERERERE 769
R R R+R R R R R + R+ R R R +++++RE+ER+ E
Sbjct: 369 NASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISE 428
Query: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNE 829
R RERER+ K + E +K +EK D + D++ + + N+
Sbjct: 429 R-RERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENK 487
Score = 98.2 bits (243), Expect = 5e-20
Identities = 76/318 (23%), Positives = 135/318 (42%), Gaps = 27/318 (8%)
Query: 675 RARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHD 734
+A ++ E R RE + E E + ER+ R R R K R + R
Sbjct: 153 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSR--- 209
Query: 735 RERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW---- 790
R+R + + R R R R R+ ++R R + ++R + RER ++R R R++++D
Sbjct: 210 RKRSQSKHRSRSHNRSRSRQ-KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKI 268
Query: 791 ------EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREH 844
++KD+ ++ REK E ++R D+ + K R +++ R+ R +EH
Sbjct: 269 KEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE---REKEH 325
Query: 845 SPDSDAYNSGDDKNEKHRLLSQVVRPQESRS------LSPSHLTEDRQGRWKEEDRKPER 898
D D + EK R + E R P R+ R +R+ R
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 385
Query: 899 KESSRR--YEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-AHDE 955
SS R + +K K S R + + + R + +D I + +R TS R + ++
Sbjct: 386 SRSSSRSPRTSKTIKRKSSRSPSPRSRNK-KDKKREKERDHISERRERERSTSMRKSSND 444
Query: 956 NKKKAKIQKKPIKKKKED 973
K K++K K+++
Sbjct: 445 RDGKEKLEKNSTSLKEKE 462
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/263 (29%), Positives = 132/263 (50%), Gaps = 28/263 (10%)
Query: 1196 RSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLK 1255
R +S S + S S R G GR R S R K++S + R+ R
Sbjct: 167 REAQSFISAAIEPESGKSNERKG----GRSR-----SHTRSKSRSSSKSHSRRKRSQSKH 217
Query: 1256 RGEP---SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERE 1312
R SRS DR+ S+S +RS R+ SRS S D R +E+ + E +R +E
Sbjct: 218 RSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIK-EKERVKE 276
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD 1372
++R R+RE +R+ +K+ +N+DRD+ ERE++RE+DK +D +RERE+ E+DRD
Sbjct: 277 KDREKEREREKEREKEKERGKNKDRDK--EREKDREKDKEKDREREREK----EHEKDRD 330
Query: 1373 RDRDRTFESSQIESVKRCEAKLEGEHERDLES--------TSRDSLALDKERMDKDLGSV 1424
+++++ + + E K +++ + ++D +S SR S + +ER + S
Sbjct: 331 KEKEKE-QDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSS 389
Query: 1425 QGFEETNKSERTESLEAGDDESK 1447
T+K+ + +S + S+
Sbjct: 390 SRSPRTSKTIKRKSSRSPSPRSR 412
Score = 94.4 bits (233), Expect = 8e-19
Identities = 81/321 (25%), Positives = 132/321 (41%), Gaps = 39/321 (12%)
Query: 266 PPPPIPEDIALGKKYKEKYKVKDRIEE---------KTRDGKDRGRDFERQREK-RDKPR 315
PP P+ A KE +V R+ E + GK R R R R K R
Sbjct: 147 PPEMTPQAAA-----KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSR 201
Query: 316 STSPAGQHHSPISSRHHSSS---SQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
S+S + S+H S S S+S +R S SP +KR+ S +++ + R
Sbjct: 202 SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 261
Query: 373 PYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSRE 432
+ +R + R + REK R + ++ DR ER ++DREKD +
Sbjct: 262 KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKER------EKDREKDKEK 315
Query: 433 ------EREYEQDQSSSRDHRDDREPRDGRDRR---DARDTRDRRELRDSRDMRDSREMR 483
E+E+E+D+ ++ D+E +DR D + +D++ R SR R
Sbjct: 316 DREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSR 375
Query: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEI 543
SR+ + R SRS R + + + R + ++ R R+H+ E
Sbjct: 376 SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER------ 429
Query: 544 RNESRNESRSEIRNDRMGRSR 564
R R+ S + NDR G+ +
Sbjct: 430 RERERSTSMRKSSNDRDGKEK 450
Score = 90.5 bits (223), Expect = 1e-17
Identities = 80/347 (23%), Positives = 155/347 (44%), Gaps = 47/347 (13%)
Query: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS-SPQRKQSPPRHR 392
S+ + G + H+ S + R+ S S+ R +RS S + S S + S R++ R +
Sbjct: 184 SNERKGGRSRSHTRS--KSRSSSKSHSRR-----KRSQSKHRSRSHNRSRSRQKDRRRSK 236
Query: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGK-RDREKDSREEREYEQDQSSSRDHRDDRE 451
SP +++ + R S+S ++R+DTR K +++E+ ++RE E+++ R+ +R
Sbjct: 237 SPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERG 296
Query: 452 PRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDRE 511
RD+ +D R++ + +D R+ +D ++ ++ +D R + + ++
Sbjct: 297 KNKDRDKEREKD-REKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKR 355
Query: 512 GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELP 571
+D +K T P RSY + SSR R SR+ SRS + + R R P
Sbjct: 356 KKD--KKSRTPP---RSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 410
Query: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR 631
+ + + + ERD ER R++ R +S + +RD
Sbjct: 411 SRNKKDKKREK---------------------ERDHISER--RERERSTSMRKSSNDRDG 447
Query: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARE 678
++ E++ S+ ++ + N E + +E VDD+ R E
Sbjct: 448 KEKLEKN---STSLKEKEHNKEPDSSVSKE------VDDKDAPRTEE 485
Score = 80.9 bits (198), Expect = 9e-15
Identities = 85/343 (24%), Positives = 138/343 (40%), Gaps = 44/343 (12%)
Query: 406 TSQSHDRRHER-REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDT 464
+ +S++R+ R R TR K S R+ Q + SR H R +
Sbjct: 181 SGKSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQ----------- 229
Query: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPR-DSRSTRDAHDYRDREGRDTHRKEDTYP 523
+DRR + R R SR SRD R D+R + + R+ R+ +
Sbjct: 230 KDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKER 289
Query: 524 EESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPEL---PEKGSRGSRG 580
E+ + G+N R++ R + R + + + R R + R + E EK R
Sbjct: 290 EKEKERGKNKDRDK-EREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRS 348
Query: 581 SQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR 640
+ID + +S P R R ++R SS ERR R R + R R
Sbjct: 349 KEIDEKRKK-------DKKSRTPPRSYNASR----RSRSSSRERR---RRRSRSSSRSPR 394
Query: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERE-RERDR 699
S I+ + R +++++ R +ERD ER RERER R+
Sbjct: 395 TSKTIKRKSSRSPSPRSRNKKDKK----------REKERDHISER-RERERSTSMRKSSN 443
Query: 700 EREKERELERERAREREREREKERDRERDRDRDHDRERERERE 742
+R+ + +LE+ +E+E KE D ++ D D++ R E
Sbjct: 444 DRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVD-DKDAPRTEE 485
Score = 80.5 bits (197), Expect = 1e-14
Identities = 71/293 (24%), Positives = 126/293 (43%), Gaps = 48/293 (16%)
Query: 1198 NRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRG 1257
+RSHT + RS S + R R R H+ SR R+K + + +K + +R
Sbjct: 192 SRSHTRSKSRSSSKSHSRRKRSQSKHRSRS-HNRSRSRQKDRRRSKSPHKKRSKSRERRK 250
Query: 1258 EPSRSTSSD-RQDSRSHSSRRS-----------SPESDRQVHSRSGSFDSRDRLQERDRY 1305
SRS S D R+D+R + E +R+ G RD+ +E+DR
Sbjct: 251 SRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDR- 309
Query: 1306 EHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERE------------------- 1346
E D+E++RER ++ E DRD +K+ ++++++R ++R +E
Sbjct: 310 EKDKEKDREREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYN 369
Query: 1347 ---------RERDKRRDLDRERERLISDSVERDRDRD---RDRTFESSQIESVK-RCEAK 1393
RER +RR R S +++R R R R + + E + +
Sbjct: 370 ASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISER 429
Query: 1394 LEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDES 1446
E E + +S D KE+++K+ S++ E + + + S E D ++
Sbjct: 430 RERERSTSMRKSSNDRDG--KEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDA 480
Score = 77.0 bits (188), Expect = 1e-13
Identities = 87/339 (25%), Positives = 139/339 (41%), Gaps = 41/339 (12%)
Query: 207 SPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSP 266
S S S RK S+S R S S + +KDR+ S SP ++ SK+ + +K R+ S
Sbjct: 204 SKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRS--KSP---HKKRSKSRERRKSRSRSHSR 258
Query: 267 PP--PIPEDIALGKKYKEKYKVKDRIEEKTRD-GKDRGRDFERQREKRDKPRSTSPAGQH 323
E I ++ KEK + K+R EK R+ K+RG++ +R +E R+K R
Sbjct: 259 DKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE-REKDREKDKEKDR 317
Query: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQ 383
H + Q + R+ +R + S P S ++ +
Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK-----KDKKSRTPPRSYNASR 372
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
R +S R R R + RTS++ R+ R R + +KD + E+E
Sbjct: 373 RSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR--NKKDKKREKE-------- 422
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
RDH +R R+ R T R+ D RD ++ E S KE DS +++
Sbjct: 423 RDHISERRERE-------RSTSMRKSSND-RDGKEKLEKNSTSLKEKEHNKEPDSSVSKE 474
Query: 504 AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542
D +D R E+ + + G L EE+ T+
Sbjct: 475 VDD------KDAPRTEENKIQHN---GNCQLNEENLSTK 504
Score = 63.5 bits (153), Expect = 1e-09
Identities = 76/289 (26%), Positives = 126/289 (43%), Gaps = 24/289 (8%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
+ K S ++ RS R R + +K++ E +K + S RK++ R + +EKE
Sbjct: 214 QSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDT-REKIKEKE 272
Query: 126 DIKIT-KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN 184
+K +E+ E E+E E E R + + D + E E R +RE K +++
Sbjct: 273 RVKEKDREKEREREKER-EKEKERGKNKDRDKEREKDREKDKEKDR---EREREKEHEKD 328
Query: 185 MEKREEIIIKKEVSPEVVRSK-LSPSPSLRKSSKSPKR--KSSPKSSSASKKDRKTSAVS 241
+K +E KE E RSK + K S++P R +S +S S+S++ R+ + S
Sbjct: 329 RDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRS 388
Query: 242 SPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG 301
S R SKT K+K R+PSP + KK K++ K +D I E+ ++R
Sbjct: 389 SS--RSPRTSKT--IKRKSSRSPSPR-------SRNKKDKKREKERDHISER----RERE 433
Query: 302 RDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR 350
R ++ D+ S H+ S S +PR
Sbjct: 434 RSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPR 482
Score = 57.0 bits (136), Expect = 1e-07
Identities = 81/355 (22%), Positives = 133/355 (37%), Gaps = 55/355 (15%)
Query: 747 KEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREE 806
K E + +E E +R RE + A E + + +R KG R R +
Sbjct: 146 KPPEMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNER------KGGRSRSHTRSK 199
Query: 807 IREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQ 866
R +SK R R+ RQ RRR SP S + + + R S+
Sbjct: 200 SRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKD-RRRSKSPHKKRSKSRERRKSRSRSHSR 258
Query: 867 VVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEI 926
R + R KE+DR+ ER+ R +E+E + K DK+RE+
Sbjct: 259 DKRKDTREKIKEKE-------RVKEKDREKEREREKEREKEKE-RGKNKDRDKEREKD-- 308
Query: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
+ +D+E DR + K+ K + K +K+KE D ER +
Sbjct: 309 ---------------REKDKE-KDREREREKEHEKDRDK--EKEKEQDKEKEREKDRSKE 350
Query: 987 EDGQVFSPKKGQ------------KKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTP 1034
D + KK + + S E++R++S+ S + K R P
Sbjct: 351 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 410
Query: 1035 PITTKEELVEMCNGKNGILEDSQKKEDTAFSDWS-DEDVPDR-----TEVTEAEH 1083
K++ E ++ I E +++ T+ S D D ++ T + E EH
Sbjct: 411 SRNKKDKKRE--KERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 463
Score = 42.0 bits (97), Expect = 0.005
Identities = 46/242 (19%), Positives = 87/242 (35%), Gaps = 39/242 (16%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
R K R + RE+ + K ++ D E ++ E KE + + +E+E
Sbjct: 285 REKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKERE 344
Query: 126 DIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENM 185
K+R+ E +E+ + + +R + R +E
Sbjct: 345 -----KDRSKEIDEKRKKDKKSRTPP-----------------RSYNASRRSRSSSRERR 382
Query: 186 EKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL 245
+R + + + ++ K S SPS R +K K++ + + +++R+ S
Sbjct: 383 RRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST------ 436
Query: 246 DQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFE 305
+++S K+K E + K KE K D K D KD R E
Sbjct: 437 SMRKSSNDRDGKEK-----------LEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEE 485
Query: 306 RQ 307
+
Sbjct: 486 NK 487
>gi|224548936 hypothetical protein LOC100170229 [Homo sapiens]
Length = 715
Score = 155 bits (391), Expect = 4e-37
Identities = 186/732 (25%), Positives = 290/732 (39%), Gaps = 100/732 (13%)
Query: 223 SSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKE 282
SSPK SS S S P D + + +K P P K
Sbjct: 2 SSPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATPNRSLVPT---------KPATS 52
Query: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI 342
+ V K+ R + R + RS + + S +S+ +S + S +
Sbjct: 53 RNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKA---RTPSRVSTDTRTSKASKASDV 109
Query: 343 QRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402
+ H +R+ T S R TP R S S S SP R +P R R+ G
Sbjct: 110 RCH----QRRGTHS----RGRTPGRRGSRS-----SKRSPSRASTPGRIRTHGARPGMAS 156
Query: 403 HERTSQSHDRRHERREDTRGKR-DREKDSREEREYEQDQS-SSRDHRDDREPRDGRDRRD 460
RT S +++ +RGK R + S ER Q ++ S + +R GR
Sbjct: 157 RVRTPTS------QQKGSRGKSYGRPRTSNRERSDSQPRNLSKKSYRPPGGSGIGRSSEL 210
Query: 461 ARDTRDRR----------ELRDSRDMRDSREMRDYSRDTKESRD----PRDSRSTRDAHD 506
A + E D+ SR+++ Y + SR+ P + S +++
Sbjct: 211 AVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSSRVKSYN 270
Query: 507 YRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGR 566
R + P SRS + R SR S S RN RSR R
Sbjct: 271 QASTRSRPQSHSQSRSPRRSRSGSQK-----------RTHSRVRSHSWKRNHSRARSRTR 319
Query: 567 VPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRH 626
L + G R SQ SHS + + +S P R R + + +R+ S ER H
Sbjct: 320 KGILSQMG----RHSQSRSHSKGKS-----QNQSRTPRRGR-----SHNWSRNPSKERSH 365
Query: 627 GERDRRDNRERDQR-PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERER 685
R ++ERD R SSP + GR+ +++R+ R R +AR+R R R
Sbjct: 366 SH-SRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSR-----SRSPNKARDRSRSRSP 419
Query: 686 DRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDR 745
+ R+R R R ++ R+ R +AR+R R R + R+ R R ++ R+R R R
Sbjct: 420 YKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSP 479
Query: 746 EKERERER-----EERERERERERERERE--------RERERERARERDKERERQRDWE- 791
KER+ + +ER+ R R +ER+ +ER+ R+R KER+R++
Sbjct: 480 SKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSP 539
Query: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAY 851
+K++ R R EE RE R R ER ++R+R SPS + ++ R S + D
Sbjct: 540 NKERDRSQSRSPSEE-REHRQSRSPSKER-DRRRWR---SPSKERERRQSRSSSEERDHS 594
Query: 852 NSGDDKNEK--HRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQE 909
S + R + SRS +PS Q R ++ P + R + +
Sbjct: 595 RSRSPNKQSGYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKR 654
Query: 910 LKEKVSSVDKQR 921
+ SS+ + R
Sbjct: 655 SPTRTSSLSQNR 666
Score = 147 bits (370), Expect = 1e-34
Identities = 183/713 (25%), Positives = 274/713 (38%), Gaps = 83/713 (11%)
Query: 197 VSPEVVRSKLSPS----PSLRKSSKSPKRKSS--PKSSSASKKDRKTSAVSSPLLDQQR- 249
+SP +S S S PS R SS+S R + P S + K S S Q+R
Sbjct: 57 MSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRG 116
Query: 250 -NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK-DRGRDFERQ 307
+S+ ++G R+ P + + + + R+ T K RG+ + R
Sbjct: 117 THSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRP 176
Query: 308 REKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPL 367
R + + P ++ S S R S SS +PS + +TP T P
Sbjct: 177 RTSNRERSDSQP--RNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTP------TGIPSK 228
Query: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDRE 427
+S +P PS S ++ +S + P REK + T S + + TR +
Sbjct: 229 EKSDNPSPSSS----RKVKSYGQMIIPSREKS---YSPTEMSSRVKSYNQASTRSRPQSH 281
Query: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487
SR R + S R H R R+ AR +R R+ + +
Sbjct: 282 SQSRSPRR-SRSGSQKRTHSRVRSHSWKRNHSRAR-SRTRKGILSQMGRHSQSRSHSKGK 339
Query: 488 DTKESRDPRDSRSTRDAHDYRDREGRD-THRKEDTYPEESRSYGRNHLREESSRTEIR-- 544
+SR PR RS H++ ++ +H + +E G + R+ES R++
Sbjct: 340 SQNQSRTPRRGRS----HNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSP 395
Query: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
N+ R+ SRS N RSR R P SR S + D +RS Y
Sbjct: 396 NKQRDHSRSRSPNKARDRSRSRSPYKARDRSRSR---------SPNKARDCSRSRSPYKA 446
Query: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664
RDR R + ++ARD S R R N+ RD R + R+ ERD +
Sbjct: 447 RDRSRSR-SPNKARDHS-------RSRSPNKARD-------RSRSRSPSKERDHSQ---- 487
Query: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724
+ RD R R R +ER + R +ERD R R +ER R + R KERD
Sbjct: 488 LGSPSKERDHR-RSRSPSKERQCRQSRSSSKERDHRR--SRSPSKERQRRQSRSPNKERD 544
Query: 725 RERDRDRDHDRERERERERDREKERERER---EERERERERERERERERERERE------ 775
R + R +RE + R +E++R R R +ERER + R ER+ R R
Sbjct: 545 RSQSRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSG 604
Query: 776 ----RARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGS 831
RA ++K R R + R +E D ++S R S
Sbjct: 605 YSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTR---TSS 661
Query: 832 PSPRQSPKRRREHSPD---SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHL 881
S ++P + HSP S D ++ S+ P E S S S L
Sbjct: 662 LSQNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSSKL 714
Score = 110 bits (274), Expect = 1e-23
Identities = 158/709 (22%), Positives = 265/709 (37%), Gaps = 129/709 (18%)
Query: 477 RDSREMRDYSRDTKESRDPRDSRSTR--DAHDYRDREGRDTHRKEDTYPEESRSYGRNHL 534
R S R S+ SR D+R+++ A D R + R TH + R+ GR
Sbjct: 77 RPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQRRGTHSR-------GRTPGRR-- 127
Query: 535 REESSRTEIRNESRNESRSEIRND--RMGR-SRGRVPELPEKGSRG-SRGSQIDSHSSNS 590
SR+ R+ SR + IR R G SR R P +KGSRG S G S+ S
Sbjct: 128 ---GSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPRTSNRERS 184
Query: 591 NYHDSWETRSSY-----------------PERDR------YPERDNRDQARDSSFER--R 625
+ ++ SY P + P ++ D SS +
Sbjct: 185 DSQPRNLSKKSYRPPGGSGIGRSSELAVTPSTAKCQTPTGIPSKEKSDNPSPSSSRKVKS 244
Query: 626 HGERDRRDNRERDQRP---SSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRE 682
+G+ +RE+ P SS ++ + R + + R R R + R R
Sbjct: 245 YGQMII-PSREKSYSPTEMSSRVKSYNQASTRSRPQSHSQSRSPR-RSRSGSQKRTHSRV 302
Query: 683 RERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERE 742
R +R R R R R+ + ++R + + + + R R R H+ R +E
Sbjct: 303 RSHSWKRNHSRARSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKE 362
Query: 743 RDREKERE--REREER-----ERERERERERERERERERERARERDKERERQRD---WED 792
R R +ER+ R +E R + ++R+ R+R +K R+R R ++
Sbjct: 363 RSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRSRSRSPYKA 422
Query: 793 KDKGRDDRREKREEIREDRNPRDGHDERKSK---KRYRNEGSPSPRQSPKRRREHSPDSD 849
+D+ R K + R+P D +S+ K + S SP ++ R R SP +
Sbjct: 423 RDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKE 482
Query: 850 AYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQE 909
+S K R RS SPS + RQ R ++R R S
Sbjct: 483 RDHSQLGSPSKER--------DHRRSRSPSKERQCRQSRSSSKERDHRRSRSP------- 527
Query: 910 LKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKK 969
S ++QR Q+ R R+Q + E R++ + + ++++ +
Sbjct: 528 ------SKERQRRQSRSPNKERDRSQSRSPSEEREHRQSRSPSKERDRRRWR-------- 573
Query: 970 KKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKR 1029
SP K E++R++S+ S+ D ++ K+
Sbjct: 574 -----------------------SPSK-------ERERRQSRSSSEERDHSRSRSPNKQS 603
Query: 1030 GPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATT 1089
G P ++KE+ + SQ + + SD S VP + + ++ +
Sbjct: 604 GYSRPRASSKEKAHSRSRTPSKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSSLS 663
Query: 1090 PGSTPSPLSSLLPPPPPV---------ATATATTVPATLAATTAAAATS 1129
TPS SS P P + A ATT ATL +++++S
Sbjct: 664 QNRTPSKTSSHSPSTFPSGGQTLSQDDSQADATTSKATLPGERSSSSSS 712
Score = 76.6 bits (187), Expect = 2e-13
Identities = 141/641 (21%), Positives = 228/641 (35%), Gaps = 110/641 (17%)
Query: 833 SPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEE 892
SP++S K +P + + D K ++ P +RSL P+ R
Sbjct: 3 SPKRSSKPSMSLAPSGSSMPTADPKPPASLKSTKSATP--NRSLVPTKPATSRNSVMSPS 60
Query: 893 DRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRM----RAQDIIGHHQSEDRET 948
K + S++R + K R + + +R +A D+ H + R T
Sbjct: 61 SSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDVRCHQR---RGT 117
Query: 949 SDRAHDENKKKAKIQKK-PIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKR 1007
R ++ ++ K+ P + + S S +KG + KS + R
Sbjct: 118 HSRGRTPGRRGSRSSKRSPSRASTPGRIRTHGARPGMASRVRTPTSQQKGSRGKSYGRPR 177
Query: 1008 KKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDW 1067
++ SD +++S + PP G +GI S
Sbjct: 178 TSNRERSDSQPRNLSKKSYR------PP------------GGSGIGRSS----------- 208
Query: 1068 SDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAA 1127
E+ TA TP PS S P P +++ V + +
Sbjct: 209 ---------ELAVTPSTAKCQTPTGIPSKEKSDNPSP-----SSSRKVKSYGQMIIPSRE 254
Query: 1128 TSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQK 1187
S+S + ++ S + +T + SH +Q R P +
Sbjct: 255 KSYSPTEMS---SRVKSYNQASTRSRPQSH--------------------SQSRSPRRSR 291
Query: 1188 RSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSL-EITGE 1246
S ++ RSH+ R S + + Q GR HS SR K KS +
Sbjct: 292 SGSQKRTHSRVRSHSWKRNHSRARSRTRKGILSQMGR----HSQSRSHSKGKSQNQSRTP 347
Query: 1247 RKSRIDQLKRG-------EPSRSTSSDRQDSRSHSSRRSSPESD------RQVHSRSGSF 1293
R+ R R SRS+S +R S S R+ S S ++ HSRS S
Sbjct: 348 RRGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRSRSP 407
Query: 1294 D-SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
+ +RDR + R Y+ R+R R R + R+ R R+R R R + R+ R +
Sbjct: 408 NKARDRSRSRSPYK-ARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRS 466
Query: 1353 RDLDRERERLISDSVERDRDR----DRDRTFESSQIESVKR-CEAKLEGEHERD------ 1401
+ R+R R S S ERD + ++R S+ S +R C ERD
Sbjct: 467 PNKARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHRRSRS 526
Query: 1402 --LESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE 1440
E R S + +KER D+ E ++ R+ S E
Sbjct: 527 PSKERQRRQSRSPNKER-DRSQSRSPSEEREHRQSRSPSKE 566
Score = 76.6 bits (187), Expect = 2e-13
Identities = 160/686 (23%), Positives = 242/686 (35%), Gaps = 76/686 (11%)
Query: 811 RNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP 870
RN KS K + +PS R S + R + + S D + K S V R
Sbjct: 53 RNSVMSPSSSKSTKSTSTKRAPSNRPSSRSRVRSKARTPSRVSTDTRTSKASKASDV-RC 111
Query: 871 QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930
+ R T R+G + R P R + R + ++S + R T + S
Sbjct: 112 HQRRGTHSRGRTPGRRGS-RSSKRSPSRASTPGRIRTHGARPGMAS--RVRTPTSQQKGS 168
Query: 931 RMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQ 990
R ++ G ++ +RE SD Q + + KK G I +SE
Sbjct: 169 RGKSY---GRPRTSNRERSDS-----------QPRNLSKKSYRPPG--GSGIGRSSELAV 212
Query: 991 VFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKN 1050
S K Q I K K SD + S+K + I ++E+ +
Sbjct: 213 TPSTAKCQTPTGIPSKEK--------SDNPSPSSSRKVKSYGQMIIPSREKSYSPTEMSS 264
Query: 1051 GILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATA 1110
+ +Q + S P R+ + T + S S A
Sbjct: 265 RVKSYNQASTRSRPQSHSQSRSPRRSRSGSQKRTHSRVRSHSWKRNHSR----------A 314
Query: 1111 TATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCH-RTRVEKVE 1169
+ T L+ + + + + + S TP ++ ++ S + H +R E
Sbjct: 315 RSRTRKGILSQMGRHSQSRSHSKGKSQNQSRTPRRGRSHNWSRNPSKERSHSHSRSSSKE 374
Query: 1170 TPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLH 1229
H P + S GS R H+ R + + D + RS R R
Sbjct: 375 RDH-----RGSSSPRKESGRSQSGSPNKQRDHSRSRSPNKARDRS-RSRSPYKARDRSRS 428
Query: 1230 SG---SRDREKTKSLEITGERKSRIDQLKRGEPSRSTSS----DRQDSRSHSSRRS---- 1278
+RD +++S +R K + SRS S DR SRS S R
Sbjct: 429 RSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRSRSPNKARDRSRSRSPSKERDHSQL 488
Query: 1279 -SPESDRQVHSRSGS-------FDSRDRLQERD-RYEHDRERERERRDTRQREWDRDADK 1329
SP +R H RS S SR +ERD R +ER+RR +R +RD +
Sbjct: 489 GSPSKERD-HRRSRSPSKERQCRQSRSSSKERDHRRSRSPSKERQRRQSRSPNKERDRSQ 547
Query: 1330 DWPRNRDRDRLRERERERERDKRR--DLDRERERLISDSVERDRDRDRDRTFESSQIESV 1387
+ +R+ + R +ERD+RR +ERER S S +RD R R+ S
Sbjct: 548 SRSPSEEREHRQSRSPSKERDRRRWRSPSKERERRQSRSSSEERDHSRSRSPNKQSGYSR 607
Query: 1388 KRCEAKLEGEHER----DLESTSRDSLALDKERMDKDLGSVQGFEETNKS-ERTESLEAG 1442
R +K E H R E S KE D +V + +S RT SL
Sbjct: 608 PRASSK-EKAHSRSRTPSKEGNHSQSRTSSKE-SDPSQSTVPRSPDWKRSPTRTSSLSQN 665
Query: 1443 DDESKLDDAHSLGSGAGEGYEPISDD 1468
SK +HS + G DD
Sbjct: 666 RTPSK-TSSHSPSTFPSGGQTLSQDD 690
Score = 62.8 bits (151), Expect = 3e-09
Identities = 82/338 (24%), Positives = 135/338 (39%), Gaps = 30/338 (8%)
Query: 64 SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDV--DTEPQKRNTEESSSPVRKESSRGRH 121
+PR +G S N+ R+P + R +K +D + P+K + S K+ R
Sbjct: 346 TPR-RGRSHNWSRNPSKERSHSHSRSSSKERDHRGSSSPRKESGRSQSGSPNKQRDHSRS 404
Query: 122 REKEDIK-ITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
R + ++ R+P + + D Y + R+ +
Sbjct: 405 RSPNKARDRSRSRSPYKARDRSRSRSPNKARDCSRSRSPYKARDRSRSRSPNKARDHSRS 464
Query: 181 EQENMEKREEIIIKKEVSPEVVRSKL-SPSPSL-RKSSKSPKRKSSPKSSSASKKDRKTS 238
N K + + S E S+L SPS + S+SP ++ + S +S K+R
Sbjct: 465 RSPN--KARDRSRSRSPSKERDHSQLGSPSKERDHRRSRSPSKERQCRQSRSSSKERDHR 522
Query: 239 AVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGK 298
SP ++QR + +K++ R+ S P +E+ + R K RD +
Sbjct: 523 RSRSPSKERQRRQSRSPNKER-DRSQSRSPS-----------EEREHRQSRSPSKERD-R 569
Query: 299 DRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPR---RKRTP 355
R R ++RE+R + RS+S H SR S + QSG S R S + R RTP
Sbjct: 570 RRWRSPSKERERR-QSRSSSEERDH-----SRSRSPNKQSGYSRPRASSKEKAHSRSRTP 623
Query: 356 SPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRS 393
S + + + + P S SP K+SP R S
Sbjct: 624 SKEGNHSQSRTSSKESDPSQSTVPRSPDWKRSPTRTSS 661
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 149 bits (376), Expect = 2e-35
Identities = 101/315 (32%), Positives = 160/315 (50%), Gaps = 21/315 (6%)
Query: 650 RNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDR------EREK 703
R ++++D + +DR +RR R+ R R R R R R+ +RE
Sbjct: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDREL 295
Query: 704 ERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE------ERE 757
ERE ER+R +EREKER R R DR +R R R RER R + R R+R+ +RE
Sbjct: 296 EREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
Query: 758 RERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKR-EEIREDRNPRDG 816
RE+E ER R R+R+ ++ER ER+KERER R+ + + R + EK+ +E ++DR RD
Sbjct: 356 REKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRD- 414
Query: 817 HDERKSKKRYRNEGSPS-PRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRS 875
D+R SKK ++ S S R+ R R + + + +K+ KH+ ++ RS
Sbjct: 415 -DKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHK--NESKEKSNKRS 471
Query: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
S S D + K+ + P +++S +R +E K D ++Q++ + R R+Q
Sbjct: 472 RSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSD-SKDQSD--KHDRRRSQ 528
Query: 936 DIIGHHQSEDRETSD 950
I Q + + D
Sbjct: 529 SIEQESQEKQHKNKD 543
Score = 145 bits (367), Expect = 2e-34
Identities = 105/321 (32%), Positives = 154/321 (47%), Gaps = 41/321 (12%)
Query: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
E DR+ ER R S RR R R + R+ SS + ELER++ R+
Sbjct: 250 EIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSF-----DRELEREKERQ-- 302
Query: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE-RAREREREREKE 722
R++ ER +ER R R DR ER R R R+R R + R +R+ R+R+REREKE
Sbjct: 303 ---RLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKE 359
Query: 723 RDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDK 782
+R R RDRD+D+ER ERE++RE+ RER +E+R R E++ + +++ R R +RD
Sbjct: 360 NERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDS 419
Query: 783 ERE--------RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSP 834
++E R+R + + R+ + R +E + + KS KR R+ GS
Sbjct: 420 KKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRS-GSQGR 478
Query: 835 RQS--PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEE 892
S ++REHSP EK R + SRS SH D +
Sbjct: 479 TDSVEKSKKREHSP----------SKEKSR--------KRSRSKERSH-KRDHSDSKDQS 519
Query: 893 DRKPERKESSRRYEEQELKEK 913
D+ R+ S E QE + K
Sbjct: 520 DKHDRRRSQSIEQESQEKQHK 540
Score = 125 bits (314), Expect = 3e-28
Identities = 108/325 (33%), Positives = 153/325 (47%), Gaps = 40/325 (12%)
Query: 562 RSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSS 621
R R R P R R S+ SH H SS+ DR ER+ Q +
Sbjct: 257 RRRSRSPRRSLSPRRSPRRSRSRSH------HREGHGSSSF---DRELEREKERQRLERE 307
Query: 622 FERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDR 681
+ R E++RR +R D+ R + R+ E R R DR DRRD RDR
Sbjct: 308 AKER--EKERRRSRSIDRGLE---RRRSRSRERHRSRSRSR---DRKGDRRD-----RDR 354
Query: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
ERE++ ER R R+R+ D+ER ERE ERER+RER +E +R R ++ H +++ R
Sbjct: 355 EREKENERGRRRDRDYDKERGNEREKERERSRERSKE---QRSRGEVEEKKHKEDKDDRR 411
Query: 742 ERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR 801
RD +++ ++E++ R R RER + R R R+R K R R R E K +++ +
Sbjct: 412 HRDDKRD---SKKEKKHSRSRSRER---KHRSRSRSRNAGK-RSRSRSKEKSSKHKNESK 464
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRR--EHSPDSDAYNSGDDKNE 859
EK + + KSKKR E SPS +S KR R E S D +S D ++
Sbjct: 465 EKSNKRSRSGSQGRTDSVEKSKKR---EHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDK 521
Query: 860 KHRLLSQVVRPQESRSLSPSHLTED 884
R SQ + E S H +D
Sbjct: 522 HDRRRSQSI---EQESQEKQHKNKD 543
Score = 121 bits (304), Expect = 5e-27
Identities = 93/319 (29%), Positives = 146/319 (45%), Gaps = 22/319 (6%)
Query: 673 DERARERDRERERDRER---ERERERERDREREKERELERERAREREREREKERDRERDR 729
D++ + R R+ ++D + E +R ER R R R L R+ R R R R+
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289
Query: 730 DRDHDRERERERERDREKEREREREER---------ERERERERERERERERERERARER 780
D + ERE+ER+R + +ERE+E R ER R R RER R R R R+R +R
Sbjct: 290 SFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR 349
Query: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR 840
++R+R+R+ E++ R DR +E E R+ ER ++R R E + K
Sbjct: 350 -RDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKD 408
Query: 841 RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDR-QGRWKEEDRKPERK 899
R H D K +KH R SRS S + R + + K K E K
Sbjct: 409 DRRHRDD----KRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESK 464
Query: 900 ESSRRYEEQELKEKVSSVD--KQREQTEILESSRMRAQDIIGHHQSEDRETSDRA--HDE 955
E S + + + SV+ K+RE + E SR R++ H+ + ++ D++ HD
Sbjct: 465 EKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDR 524
Query: 956 NKKKAKIQKKPIKKKKEDD 974
+ ++ Q+ K+ K D
Sbjct: 525 RRSQSIEQESQEKQHKNKD 543
Score = 112 bits (281), Expect = 2e-24
Identities = 92/328 (28%), Positives = 145/328 (44%), Gaps = 39/328 (11%)
Query: 521 TYPEESRSYGRNHLREESSRTEIR-NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSR 579
T P + + G+ E E R + S S S R+ R RSR E G
Sbjct: 235 TRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHRE-------GHG 287
Query: 580 GSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHG---ERDRRDNRE 636
S D E + E++R R ++ D ERR ER R +R
Sbjct: 288 SSSFDRELEREKERQRLEREAKEREKER-----RRSRSIDRGLERRRSRSRERHRSRSRS 342
Query: 637 RDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERE 696
RD++ R + R E ER RR+ D ER ER++ERER RER +E+
Sbjct: 343 RDRKGDRRDRDREREKENERGRRRDR-------DYDKERGNEREKERERSRERSKEQRSR 395
Query: 697 RDREREKERELE---RERAREREREREKERDRERDRDRDH-DRER-----ERERERDREK 747
+ E +K +E + R R +R+ ++EK+ R R R+R H R R +R R R +EK
Sbjct: 396 GEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK 455
Query: 748 EREREREERERERERERERER------ERERERERARERDKERERQRDWEDKDKGRDDRR 801
+ + E +E+ +R R + E+ ++RE + ++K R+R R E K RD
Sbjct: 456 SSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHK-RDHSD 514
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNE 829
K + + DR ++ +K+++N+
Sbjct: 515 SKDQSDKHDRRRSQSIEQESQEKQHKNK 542
Score = 107 bits (268), Expect = 7e-23
Identities = 88/337 (26%), Positives = 145/337 (43%), Gaps = 30/337 (8%)
Query: 468 RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESR 527
R + +D ++ E D + + SR PR S S R + R R HR+ R
Sbjct: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSP--RRSRSRSHHREGHGSSSFDR 293
Query: 528 SYGRNHLREESSR-TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSH 586
R R+ R + R + R SRS R RSR R SR +G + D
Sbjct: 294 ELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRD-- 351
Query: 587 SSNSNYHDSWETRSSYPERDRYPERDN-RDQARDSSFERRHGERDRRDNRERDQRPSSPI 645
RDR E++N R + RD +++ G +R RER + S
Sbjct: 352 ------------------RDREREKENERGRRRDRDYDKERGN-EREKERERSRERSKEQ 392
Query: 646 RHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKER 705
R +G +E + E +++RR DD+RD + +E+ R R RER + R R R R K
Sbjct: 393 RSRGEVEEKKHKEDKDDRR--HRDDKRDSK-KEKKHSRSRSRER-KHRSRSRSRNAGKRS 448
Query: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765
+ + + KE+ +R R R E+ + RE +E+ R+R R +ER
Sbjct: 449 RSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS-RKRSRSKERS 507
Query: 766 RERERERERERARERDKERERQRDWEDKDKGRDDRRE 802
+R+ ++++ + D+ R + + E ++K ++ E
Sbjct: 508 HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 105 bits (262), Expect = 3e-22
Identities = 85/335 (25%), Positives = 137/335 (40%), Gaps = 27/335 (8%)
Query: 486 SRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRN 545
+R K +D ++ D H R R R R RS R+H RE +
Sbjct: 235 TRPRKIKKDGKEGAEEIDRHVER-RRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDR 293
Query: 546 ESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPER 605
E E + R +R + R EK R SR S + +RS R
Sbjct: 294 ELEREKERQ-RLEREAKER-------EKERRRSRSIDRGLERRRSRSRERHRSRSR--SR 343
Query: 606 DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRV 665
DR +R +RD+ R+ + ER RR +R+ D + +G E ER+ RE +
Sbjct: 344 DRKGDRRDRDRERE-----KENERGRRRDRDYD-------KERGNEREKERERSRERSKE 391
Query: 666 DRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDR 725
R +E+ + D++ R R+ +R+ ++E+ R + RE + R+R R R K R
Sbjct: 392 QRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE-RKHRSRSRSRNAGK---R 447
Query: 726 ERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERE 785
R R ++ + + E + K + R E+ ++RE +E+ R R R KER
Sbjct: 448 SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERS 507
Query: 786 RQRDWEDKDKGRDDRREKREEIREDRNPRDGHDER 820
+RD D D +R + E + H +
Sbjct: 508 HKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNK 542
Score = 98.2 bits (243), Expect = 5e-20
Identities = 88/326 (26%), Positives = 140/326 (42%), Gaps = 36/326 (11%)
Query: 449 DREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKE-SRDPRDSRSTRDAHDY 507
DR R R R RR R SR RE S +E R+ R R+A +
Sbjct: 252 DRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKE- 310
Query: 508 RDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRV 567
R++E R SRS R L SR+ R+ SR+ SR DR G R R
Sbjct: 311 REKERR-----------RSRSIDRG-LERRRSRSRERHRSRSRSR-----DRKGDRRDRD 353
Query: 568 PELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHG 627
E ++ RG R + D N + ER+R ER ++R E++H
Sbjct: 354 REREKENERGRRRDR-DYDKERGNEREK--------ERERSRERSKEQRSRGEVEEKKHK 404
Query: 628 ERDRRDNRERD-QRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERD 686
E D+ D R RD +R S + R+ ER R R +R+R R +E+
Sbjct: 405 E-DKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSR-----SRNAGKRSRSRSKEKSSK 458
Query: 687 RERE-RERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDR 745
+ E +E+ +R R + R E++++RE KE+ R+R R ++ +R+ +D+
Sbjct: 459 HKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQ 518
Query: 746 EKEREREREERERERERERERERERE 771
+ +R R + + +E++ + + E
Sbjct: 519 SDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 97.1 bits (240), Expect = 1e-19
Identities = 87/350 (24%), Positives = 143/350 (40%), Gaps = 68/350 (19%)
Query: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ 440
SP+R SP R R + H S S DR ER ++ R R + +ERE E+ +
Sbjct: 262 SPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE----RQRLEREAKEREKERRR 317
Query: 441 SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500
S S D G +RR +R R SRD + R RD R+ + R R R
Sbjct: 318 SRSIDR--------GLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDR- 368
Query: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
DY G + E+ R R +E+ SR E+ + E ++DR
Sbjct: 369 -----DYDKERGNER--------EKERERSRERSKEQRSRGEVEEKKHKED----KDDRR 411
Query: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
R R + +K SR S+ H S S R R + +R ++++
Sbjct: 412 HRDDKRDSKKEKKHSRSR--SRERKHRSRS--------------RSRNAGKRSRSRSKEK 455
Query: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
S + ++ +++ + R R QGR D +E+ ++RE
Sbjct: 456 SSKHKNESKEKSNKRSRS-------GSQGRTDSVEKSKKRE---------------HSPS 493
Query: 681 RERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730
+E+ R R R +ER +RD K++ + +R R + E+E + + +++D
Sbjct: 494 KEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 90.5 bits (223), Expect = 1e-17
Identities = 84/303 (27%), Positives = 130/303 (42%), Gaps = 16/303 (5%)
Query: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDRE 427
RRS SP S SP+R SP R RS + H + +R ER+ R ++RE
Sbjct: 258 RRSRSPRRS---LSPRR--SPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKERE 312
Query: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487
K+ R R ++ R +R R R D RDR R+ + R R RDY +
Sbjct: 313 KERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK 372
Query: 488 DTKESRDPRDSRSTRDAHDYRDR-EGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNE 546
+ R+ RS + + R R E + KED R R+ +E+ E
Sbjct: 373 ERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRE 432
Query: 547 SRNESRSEIRNDRMGRSRGRVPELPEKGSRGSR-GSQIDSHSSNSNYHDSWETRSSYPER 605
++ SRS RN RSR R E K S+ S S S + DS E +R
Sbjct: 433 RKHRSRSRSRNAGK-RSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSK---KR 488
Query: 606 DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRV 665
+ P ++ + + R S ER H +RD D++++ + R + ++ E E E++ + +
Sbjct: 489 EHSPSKE-KSRKRSRSKERSH-KRDHSDSKDQSDKHD---RRRSQSIEQESQEKQHKNKD 543
Query: 666 DRV 668
+ V
Sbjct: 544 ETV 546
Score = 81.6 bits (200), Expect = 5e-15
Identities = 74/323 (22%), Positives = 135/323 (41%), Gaps = 33/323 (10%)
Query: 264 PSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFER---QREKRDKPRSTSPA 320
P P P+ ++I ++K R + +DGK+ + +R +R R RS SP
Sbjct: 219 PRIPVPVQKNI--------DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPR 270
Query: 321 GQHHSPISSRHHSSSSQSGS------------SIQRHSPSPRRKRTPSPSYQRTLTPPLR 368
S HH S S ++R + ++R S S R L R
Sbjct: 271 RSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLER--R 328
Query: 369 RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREK 428
RS S S S + ++ R R REK R + +D+ + +R RE+
Sbjct: 329 RSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRER 388
Query: 429 DSREEREYEQDQSSSRDHRDDREPRDGR--DRRDARDTRDRRELRDSRDMRDSREMRDYS 486
+ E ++ ++ +DDR RD + +++ + +R R R R SR S
Sbjct: 389 SKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRS 448
Query: 487 RDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES---SRTEI 543
R + + + +++ + R R G + + D+ E+S+ + +E+S SR++
Sbjct: 449 RSRSKEKSSKHKNESKEKSNKRSRSG--SQGRTDSV-EKSKKREHSPSKEKSRKRSRSKE 505
Query: 544 RNESRNESRSEIRNDRMGRSRGR 566
R+ R+ S S+ ++D+ R R +
Sbjct: 506 RSHKRDHSDSKDQSDKHDRRRSQ 528
Score = 80.1 bits (196), Expect = 2e-14
Identities = 85/347 (24%), Positives = 145/347 (41%), Gaps = 50/347 (14%)
Query: 739 RERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRD 798
+ R R +K+ + EE +R ER R R R R+ R + R R E
Sbjct: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHR--EGHGSSSF 291
Query: 799 DRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKN 858
DR +RE+ R+ ER++K+R + +RRR S D
Sbjct: 292 DRELEREKERQRL-------EREAKEREK-----------ERRRSRSIDRGLERRRSRSR 333
Query: 859 EKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK-ESSRRYEEQELKEKVSSV 917
E+HR SRS S DR+G ++ DR+ E++ E RR + KE+ +
Sbjct: 334 ERHR----------SRSRS-----RDRKGDRRDRDREREKENERGRRRDRDYDKERGNER 378
Query: 918 DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGI 977
+K+RE++ + ++ ED++ DR H ++K+ +K +KK + + +
Sbjct: 379 EKERERSRERSKEQRSRGEVEEKKHKEDKD--DRRHRDDKRDSKKEKKHSRSRSRERKHR 436
Query: 978 ERGNIETTSEDGQVFSPKKGQKKK--SIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPP 1035
R + + S +K K K S EK K+S+ S + + K++ P
Sbjct: 437 SRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP---- 492
Query: 1036 ITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082
+KE+ + K E S K++ + D SD+ R++ E E
Sbjct: 493 --SKEKSRKRSRSK----ERSHKRDHSDSKDQSDKHDRRRSQSIEQE 533
Score = 79.3 bits (194), Expect = 3e-14
Identities = 77/285 (27%), Positives = 123/285 (43%), Gaps = 44/285 (15%)
Query: 1237 KTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSG----S 1292
KT+ +I + K +++ R R + S R RS S RRS S + H R G S
Sbjct: 234 KTRPRKIKKDGKEGAEEIDRHVERRRSRSPR---RSLSPRRSPRRSRSRSHHREGHGSSS 290
Query: 1293 FDSR-DRLQERDRYEHD---------------------RERERERRDTRQREWDRDADKD 1330
FD +R +ER R E + R R RER +R R DR D+
Sbjct: 291 FDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDR- 349
Query: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFES---SQIESV 1387
R+RDR+R +E ER R RD+ D +R ER E++R+R R+R+ E ++E
Sbjct: 350 --RDRDREREKENERGRRRDRDYDKERGNER------EKERERSRERSKEQRSRGEVEEK 401
Query: 1388 KRCEAKLEGEH---ERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDD 1444
K E K + H +RD + + S + +ER + + + ++S E +
Sbjct: 402 KHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKN 461
Query: 1445 ESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
ESK SG+ + + + E + R+ + +E+
Sbjct: 462 ESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKER 506
Score = 68.9 bits (167), Expect = 4e-11
Identities = 76/273 (27%), Positives = 112/273 (41%), Gaps = 31/273 (11%)
Query: 1182 KPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSL 1241
+P K+ G+ +R R RSP + R +S R+ S R+ + S
Sbjct: 236 RPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPR----RSPRRSRSRSHHREGHGSSSF 291
Query: 1242 EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQE 1301
+ ER+ +L+R R R S R S + SRS S RDR +
Sbjct: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRS---RDRKGD 348
Query: 1302 RDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRE-RE 1360
R DR+RERE+ + R R DRD DK+ R ERE+ER++ R+ +E R
Sbjct: 349 R----RDRDREREKENERGRRRDRDYDKE----------RGNEREKERERSRERSKEQRS 394
Query: 1361 RLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRD------SLALDK 1414
R + + D+D DR + +S K + ER S SR S + K
Sbjct: 395 RGEVEEKKHKEDKD-DRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSK 453
Query: 1415 ERMDKDLGSVQGFEETNKSERTESLEAGDDESK 1447
E+ K + E++NK R+ S D K
Sbjct: 454 EKSSKHKN--ESKEKSNKRSRSGSQGRTDSVEK 484
Score = 68.2 bits (165), Expect = 6e-11
Identities = 73/300 (24%), Positives = 123/300 (41%), Gaps = 21/300 (7%)
Query: 1195 NRSNRSHTSGRLRSPSND---SAHRSGDDQSGRKRVLH-SGSRDREKTKSLEITGERKSR 1250
+RS R S R RSP S HR G S R L R R + ++ E ER+ R
Sbjct: 260 SRSPRRSLSPR-RSPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERR-R 317
Query: 1251 IDQLKRG-EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDR 1309
+ RG E RS S +R SRS S R DR + R R ++ D+ E
Sbjct: 318 SRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGRRRDRDYDK-ERGN 376
Query: 1310 ERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVER 1369
ERE+ER +R+R ++ R R + E++ + ++D RR D +R+ R
Sbjct: 377 EREKERERSRERSKEQ---------RSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSR 427
Query: 1370 DRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEE 1429
R R+R S + KR ++ + + + + S +K G E+
Sbjct: 428 SRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKS---NKRSRSGSQGRTDSVEK 484
Query: 1430 TNKSERTESLEAGDDESKLDD-AHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEE 1488
+ K E + S E S+ + +H + D + + ++++++ + +E
Sbjct: 485 SKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 66.6 bits (161), Expect = 2e-10
Identities = 76/355 (21%), Positives = 137/355 (38%), Gaps = 46/355 (12%)
Query: 90 KNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPE---SEEENVEWET 146
KN Q + T P+K ++K+ G ++ + R+P S +
Sbjct: 227 KNIDQQIKTRPRK---------IKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSR 277
Query: 147 NRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKRE---EIIIKKEVSPEVVR 203
+R G + + EL E +RQ+++RE + E+E R + ++ S E R
Sbjct: 278 SRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHR 337
Query: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRT 263
S+ S S + + R+ ++ ++DR +++R +SK++ R
Sbjct: 338 SR-SRSRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRG 396
Query: 264 PSPPPPIPEDIALGKKYKEKY---KVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPA 320
ED + +K K K ++R+ K R R R KR + RS +
Sbjct: 397 EVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKS 456
Query: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
+H + S + S+SGS + S +KR SPS +++
Sbjct: 457 SKHKNE-SKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKS------------------ 497
Query: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE 435
RK+S + RS R DH + D+ RR + + +EK + + E
Sbjct: 498 ---RKRSRSKERSHKR-----DHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 65.9 bits (159), Expect = 3e-10
Identities = 73/270 (27%), Positives = 114/270 (42%), Gaps = 30/270 (11%)
Query: 1175 IEDAQHRKPMDQKRSSSLGSNRSNRSHTSG--RLRSPSNDSAHRSGDDQSGRKRVLHSGS 1232
+E + R+ ++++ R +RS G R RS S + HRS RK
Sbjct: 295 LEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRER-HRSRSRSRDRKGDRRDRD 353
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR-QVHSRSG 1291
R+REK G R+ R +RG ++R+ R S RS + R +V +
Sbjct: 354 REREKENE---RGRRRDRDYDKERG-------NEREKERERSRERSKEQRSRGEVEEKKH 403
Query: 1292 SFDSRDRLQERDRYE------HDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERER 1345
D DR D+ + H R R RER+ R R R+A K R+R R + + +
Sbjct: 404 KEDKDDRRHRDDKRDSKKEKKHSRSRSRERKH-RSRSRSRNAGK---RSRSRSKEKSSKH 459
Query: 1346 ERE-RDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLES 1404
+ E ++K R + +DSVE+ + R+ + E S+ KR +K E H+RD
Sbjct: 460 KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSR----KRSRSK-ERSHKRDHSD 514
Query: 1405 TSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
+ S D+ R Q + NK E
Sbjct: 515 SKDQSDKHDRRRSQSIEQESQEKQHKNKDE 544
Score = 62.8 bits (151), Expect = 3e-09
Identities = 60/268 (22%), Positives = 112/268 (41%), Gaps = 22/268 (8%)
Query: 1157 HRKCHRT----RVEKVETPHVTIEDAQHRKPMDQKRSSSLG---SNRSNRSHTSGRLRSP 1209
HR+ H + R + E +E + +++RS S+ R +RS R RS
Sbjct: 282 HREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSR 341
Query: 1210 SND--------SAHRSGDDQSGRKRVL-HSGSRDREKTKSLEITGERKSRIDQLKRGEPS 1260
S D R +++ GR+R + R E+ K E + ER +Q RGE
Sbjct: 342 SRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSK--EQRSRGEVE 399
Query: 1261 RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ 1320
+ +D R H + + +++ HSRS S + + R + R R R R R + + +
Sbjct: 400 EKKHKEDKDDRRHRDDKRDSKKEKK-HSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSK 458
Query: 1321 REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE 1380
++ K+ R R + R E+ K+R+ +E+ S ++R RD +
Sbjct: 459 H---KNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDS 515
Query: 1381 SSQIESVKRCEAKLEGEHERDLESTSRD 1408
Q + R ++ + ++ + ++D
Sbjct: 516 KDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 56.6 bits (135), Expect = 2e-07
Identities = 65/265 (24%), Positives = 107/265 (40%), Gaps = 17/265 (6%)
Query: 64 SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSS-------PVRKES 116
SPR S++R + D + +RQ ++ E ++R E S R+
Sbjct: 272 SPRRSRSRSHHREGHGSSSFDRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSR 331
Query: 117 SRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRE 176
SR RHR + +++R + + + E E + D +YD E +R++ RE
Sbjct: 332 SRERHRSRSR---SRDRKGDRRDRDREREKENERGRRRDRDYDKERGNEREKERER-SRE 387
Query: 177 LMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
K EQ + + EE K++ R S +K S+S R+ +S S S+ K
Sbjct: 388 RSK-EQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGK 446
Query: 237 TSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYK---EKYKVKDRIEEK 293
S S ++ K +K R+ S + + KK + K K + R K
Sbjct: 447 RSRSRSK--EKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSK 504
Query: 294 TRDGKDRGRDFERQREKRDKPRSTS 318
R K D + Q +K D+ RS S
Sbjct: 505 ERSHKRDHSDSKDQSDKHDRRRSQS 529
Score = 31.2 bits (69), Expect = 8.2
Identities = 27/132 (20%), Positives = 53/132 (40%), Gaps = 5/132 (3%)
Query: 61 HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVR--KESSR 118
H R + RS R + + R +++ ++ + R+ E+SS KE S
Sbjct: 412 HRDDKRDSKKEKKHSRSRSR---ERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSN 468
Query: 119 GRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELM 178
R R + + E + E +R S + + ++ H S + + +R
Sbjct: 469 KRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQ 528
Query: 179 KLEQENMEKREE 190
+EQE+ EK+ +
Sbjct: 529 SIEQESQEKQHK 540
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 149 bits (375), Expect = 3e-35
Identities = 199/838 (23%), Positives = 329/838 (39%), Gaps = 147/838 (17%)
Query: 169 KRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSS 228
+RQ I+ +LE N+++ +E + ++E + VR + LR+ +K +++ +
Sbjct: 571 RRQTIEERKERLESLNIQREKEELEQREAELQKVRK--AEEERLRQEAKEREKERILQEH 628
Query: 229 SASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKD 288
KK L+Q + ++ K P D + K+ ++ K K
Sbjct: 629 EQIKKKTVRER-----LEQIKKTELGAKAFKDIDIEDLEELDP-DFIMAKQVEQLEKEKK 682
Query: 289 RIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQ--RHS 346
++E+ ++ + + FER + + P S + + +++Q R
Sbjct: 683 ELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREK 742
Query: 347 PSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERT 406
+ R R L ++A +QS + E+ R ER
Sbjct: 743 ALEHKNRMSRMLEDRDLFVMRLKAA-------------RQSVYEEKLKQFEE-RLAEERH 788
Query: 407 SQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRD--DREPRDGRDRRDARDT 464
++ +R+ +R+E+ R REK+ E+R E+ R+ R+ +R R+ R
Sbjct: 789 NRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERV 848
Query: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524
+ E+ + R+ E+ + R +E R DS +R + DR+ T RK PE
Sbjct: 849 KKLEEVERKKRQRE-LEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKG---PE 904
Query: 525 ESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPEL-------PEKGSRG 577
+ R +E R E R+E R+ R E R R+G R P L P +G
Sbjct: 905 ADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDD 964
Query: 578 SRGSQIDSHSSNSNYHDSWETRSSY--------PERDRYPERDNRDQARDSSFERRHGER 629
RG + + + + R S+ P R +R N A D RR +
Sbjct: 965 DRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDE 1024
Query: 630 DRRDNR--ERDQRPSSPI------RHQGRNDELER-----DERREERRVDRVDDRRDERA 676
DR R + D+ P + R G +DE D+R R +D DDR R
Sbjct: 1025 DRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLD--DDRGPRRG 1082
Query: 677 RERDRERERDRERERERERERDREREKERELERERARERERE------REKERDRERDRD 730
+ DR R + +R R D +R R L+ +R R + R E DR R+
Sbjct: 1083 MDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRN 1142
Query: 731 RDHDR----------------------------------ERERE--------------RE 742
D DR E+ RE RE
Sbjct: 1143 MDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEERE 1202
Query: 743 RDREKERER---EREERERERERERERERERERERERARERDK------ERERQRDWEDK 793
DREKER+R +REE +++ ERER+RER+ +RE R RD+ E W D
Sbjct: 1203 WDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDS 1262
Query: 794 ----DKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSD 849
D+ RDDRR +R++ R+ R RD D+R R+ P R E S
Sbjct: 1263 SRRDDRDRDDRRRERDDRRDLRERRDLRDDR-------------DRRGPPLRSEREEVSS 1309
Query: 850 AYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE 907
+ D K+++ V R + P L+ DR+ R ++ +R+ E++++S R E+
Sbjct: 1310 WRRADDRKDDR------VEERDPPRRVPPPALSRDRE-RDRDREREGEKEKASWRAEK 1360
Score = 136 bits (342), Expect = 2e-31
Identities = 200/852 (23%), Positives = 321/852 (37%), Gaps = 90/852 (10%)
Query: 89 MKNKRQDVDTEPQKRNTEES------SSPVRKESSRGRHREKEDIKITKERTPESEEENV 142
+KN R++ +R T E S +++E RE E K+ K +E
Sbjct: 558 LKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAK 617
Query: 143 EWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMK-LEQENMEKREEIIIKKEVSPEV 201
E E R ++ I V E ++K+ ++ + K ++ E++E+ + I + ++
Sbjct: 618 EREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQL 677
Query: 202 VRSKLSPSPSLRKSSK-------SPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTN 254
+ K L+ K + + + P SA ++ R +++R +
Sbjct: 678 EKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQ 737
Query: 255 QSKKKGPRTPSPPPPIPED---------IALGKKYKEKYKV---------KDRIEEKTRD 296
++K + + ED A Y+EK K +R+EE+ R
Sbjct: 738 LEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQ 797
Query: 297 GKDRGR-----DFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRR 351
K+ R + E + ++R + + + ++ + +++ R+
Sbjct: 798 RKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERK 857
Query: 352 KRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHE---RTSQ 408
KR + R SLS + R+ D E +
Sbjct: 858 KRQRELEIEER--ERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPE 915
Query: 409 SHDRRHERREDTRG-KRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDR 467
RR E R++ R +RD E+ R + +++ S D DDR PR G D D R
Sbjct: 916 KEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPD--DDRVPRRGMDD-DRGPRRGP 972
Query: 468 RELRDSRDMRDSREMRDYSRDTKESRDPR-----DSRSTRDAHDYRD-REGRDTHRKEDT 521
E R SR R + + R R+T + R PR D + R A D R R G D R
Sbjct: 973 EEDRFSR--RGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWR 1030
Query: 522 YPEESRSYGRNHLREESSRTEIRNESRNESRS--EIRNDRMGRSRGRVPELPEKGSRGSR 579
+E R R + R ++ R+ R+ + R R G R P RG R
Sbjct: 1031 TADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPR 1090
Query: 580 GSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQ 639
D D R + DR P R+ A D RR E DR R D
Sbjct: 1091 RGMDDDRGPRRGMDDDRGPRRGLDD-DRGPWRN----ADDDRIPRRGAEDDRGPWRNMD- 1144
Query: 640 RPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARE-------RDRERERDRERERE 692
+D L R ++R R DD R R R++E+ R+
Sbjct: 1145 -----------DDRLSR-RADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPP 1192
Query: 693 RERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERE 752
RE ERE +RE ER+R + E +K+ +RERDR+RD DRE R RD R
Sbjct: 1193 RESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGP 1252
Query: 753 REERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRN 812
EE R+ R +R+R+ R +R RER+ +D+D+ R +REE+ R
Sbjct: 1253 AEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRR 1312
Query: 813 PRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQE 872
D D+R ++ P P R+ D D G EK + + + +E
Sbjct: 1313 ADDRKDDRVEER-----DPPRRVPPPALSRDRERDRDREREG----EKEKASWRAEKDRE 1363
Query: 873 SRSLSPSHLTED 884
S + + ED
Sbjct: 1364 SLRRTKNETDED 1375
Score = 119 bits (298), Expect = 2e-26
Identities = 174/755 (23%), Positives = 296/755 (39%), Gaps = 107/755 (14%)
Query: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESE 138
E+ +L+ER+KN+ + +D + + EE P+ K + + + D+ + E
Sbjct: 678 EKEKKELQERLKNQEKKIDYFERAKRLEEI--PLIKSAYEEQRIKDMDL------WEQQE 729
Query: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVS 198
EE + +++++R+K ++ + +E R+ +++ + +
Sbjct: 730 EERIT---------------------TMQLEREKALEHKNRMSRM-LEDRDLFVMRLKAA 767
Query: 199 PEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK 258
+ V + R + + R K K++R+ + ++QR ++ K+
Sbjct: 768 RQSVYEEKLKQFEERLAEERHNRLEERKRQR--KEERRITYYREKEEEEQRRAEEQMLKE 825
Query: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTR------DGKDRGRDFERQREKRD 312
+ R + E++ ++Y+E+ K + +E K R + ++R R+ ER+
Sbjct: 826 REERERAERAKREEEL---REYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSS 882
Query: 313 KPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRT---------- 362
R S G S + R ++ S +R P +R R+
Sbjct: 883 LSRKDSRWGDRDSEGTWR---KGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRR 939
Query: 363 ------LTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHER 416
P LR P + + + P R D + D R R
Sbjct: 940 LGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPR 999
Query: 417 R---EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRD-----RRDARDTRDRR 468
R ED R + D R ++D+ S R +DR PR G D RR D +R
Sbjct: 1000 RIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADD-ERS 1058
Query: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDA--HDYRDREGRDTHRKEDTYPEES 526
R++ D R R D R + D D R R D R G D R ++
Sbjct: 1059 SWRNADDDRGPRRGLDDDRGPRRGMD--DDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDD 1116
Query: 527 RSYGRNHLREESSRTEIRNESRNESRSEIRN---DRMGRSRGRVPELPEKGSRGSRGSQI 583
R RN + I + R RN DR+ R R P +G G
Sbjct: 1117 RGPWRN-----ADDDRIPRRGAEDDRGPWRNMDDDRLSR-RADDDRFPRRGDDSRPGPWR 1170
Query: 584 DSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSS 643
W + E P R++R + + ++R ERDR DN++R++
Sbjct: 1171 PLVKPGG-----WREKEKAREESWGPPRESRP-SEEREWDREK-ERDR-DNQDREENDKD 1222
Query: 644 PIRHQGRNDELERDERREERRVDRVDDRR---DERARERDRERERDRERE-RERERERDR 699
P R + R +++R++R R D RR +E + RD R DR+R+ R RER+ R
Sbjct: 1223 PERERDRERDVDREDRFRRPR-DEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRR 1281
Query: 700 EREKERELERERARER---EREREKERDRERDRDRDHDRERERERER---DREKERERER 753
+ + R+L +R R ERE+ R DR DR ER+ R R+RER
Sbjct: 1282 DLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRER 1341
Query: 754 EERERERERERER-----ERERERERERARERDKE 783
+ R+RERE E+E+ E++RE R E D++
Sbjct: 1342 D-RDREREGEKEKASWRAEKDRESLRRTKNETDED 1375
Score = 105 bits (261), Expect = 4e-22
Identities = 144/615 (23%), Positives = 255/615 (41%), Gaps = 99/615 (16%)
Query: 404 ERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARD 463
+ + + H R RR+ +++R + +RE E+ + + + R+ + R R++A++
Sbjct: 559 KNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKE 618
Query: 464 TRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYP 523
R L++ ++ + T R + ++ A ++D + D E+ P
Sbjct: 619 REKERILQEHEQIK---------KKTVRERLEQIKKTELGAKAFKDIDIEDL---EELDP 666
Query: 524 EESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQI 583
+ + L +E + E++ +N+ E + D R++ R+ E+P
Sbjct: 667 DFIMAKQVEQLEKE--KKELQERLKNQ---EKKIDYFERAK-RLEEIP------------ 708
Query: 584 DSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR------RDNRER 637
+S+Y E R + D +Q + ER++ R +R
Sbjct: 709 -------------LIKSAY-EEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRML 754
Query: 638 DQRPSSPIRHQGRNDEL--ERDERREERRVDRVDDRRDERARERDRERERDRERERERER 695
+ R +R + + E+ ++ EER + +R +ER R+R ER RE+E E
Sbjct: 755 EDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEE 814
Query: 696 ERDRERE--KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERER 753
+R E + KERE ERERA +RE E +ER + + ++R+RE + E ERER R
Sbjct: 815 QRRAEEQMLKERE-ERERAERAKREEELREYQERVKKLEEVERKKRQRELEIE-ERERRR 872
Query: 754 EERER------ERERERERERERERERERARERDKERER---QRDW-------EDKDKGR 797
EE R R+ R +R+ E + E D E R +++W ED+ R
Sbjct: 873 EEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRR 932
Query: 798 DDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR----RREHSPDSDAYNS 853
D+ R +R EDR P D+ + +R ++ PR+ P+ RR D ++ +
Sbjct: 933 DEERPRRLGDDEDREPSLRPDDDRVPRRGMDD-DRGPRRGPEEDRFSRRGADDDRPSWRN 991
Query: 854 GDDKNEKHRLLSQ---VVRPQESRSLSPSHLTEDRQGRWK--EEDRKPERKESSRRYEEQ 908
DD R+ + R + L EDR G W+ +EDR P RR +
Sbjct: 992 TDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDR-GSWRTADEDRGP------RRGMDD 1044
Query: 909 ELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRA---HDENKKKAKIQKK 965
+ + D +R SS A D G + D + R D ++ +
Sbjct: 1045 DRGPRRGGADDER-------SSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDR 1097
Query: 966 PIKKKKEDDVGIERG 980
++ +DD G RG
Sbjct: 1098 GPRRGMDDDRGPRRG 1112
Score = 92.8 bits (229), Expect = 2e-18
Identities = 178/853 (20%), Positives = 339/853 (39%), Gaps = 145/853 (16%)
Query: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREK--ERELERERA 712
E++E+ + + + R E R R + + +ER RE+E+ +RE E ++
Sbjct: 545 EKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKV 604
Query: 713 REREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERER 772
R+ E ER ++ +E RE+ER + + +++ RE E+ ++ E + ++
Sbjct: 605 RKAEEERLRQEAKE--------REKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDI 656
Query: 773 ERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSP 832
+ E E D + + E +K +++E +E ++ D + K R E P
Sbjct: 657 DIEDLEELDPDFIMAKQVEQLEK---EKKELQERLKNQEKKIDYFERAK-----RLEEIP 708
Query: 833 SPRQSPKRRREHSPDSDAYNSGDDKN------EKHRLL---SQVVRPQESRSLSPSHLTE 883
+ + + +R D D + +++ E+ + L +++ R E R L L
Sbjct: 709 LIKSAYEEQR--IKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKA 766
Query: 884 DRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQS 943
RQ ++E+ +++EE+ +E+ + +++++ Q + E R I +++
Sbjct: 767 ARQSVYEEK---------LKQFEERLAEERHNRLEERKRQRK--EERR------ITYYRE 809
Query: 944 EDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSI 1003
++ E RA ++ K+ + +++ + K+E+++ + ++ E KK Q++ I
Sbjct: 810 KEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEE----VERKKRQRELEI 865
Query: 1004 EKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTA 1063
E++ ++ + + + D +++ + G R T ++ + G E ++ +
Sbjct: 866 EERERRREEERRLGDSSLSRKD-SRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGR 924
Query: 1064 FSDWS---DEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLA 1120
D S DE+ P R + + E + P P + P
Sbjct: 925 DEDRSHRRDEERPRR--LGDDEDREPSLRPDDDRVPRRGMDDDRGP-------------- 968
Query: 1121 ATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQH 1180
FS + ++ N D R R E +D
Sbjct: 969 -RRGPEEDRFSRRG---------ADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPP 1018
Query: 1181 RKPMDQKRSSSLGSN-----RSNRSHTSGRLRSPSND--SAHRSGDDQSGRKRVLHSGSR 1233
R+ +D+ R S ++ R G R ++D S+ R+ DD G +R L
Sbjct: 1019 RRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDD--- 1075
Query: 1234 DREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSS-PESDRQVHSRSG 1291
DR + + + G R+ D RG P R DR R R +D R G
Sbjct: 1076 DRGPRRGMDDDRGPRRGMDDD--RG-PRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRG 1132
Query: 1292 SFDSR--------DRLQER---DRY----------------------EHDRERE------ 1312
+ D R DRL R DR+ E ++ RE
Sbjct: 1133 AEDDRGPWRNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPP 1192
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD 1372
RE R + +REWDR+ ++D N+DR+ +++ ERERD+ RD+DRE D R RD
Sbjct: 1193 RESRPSEEREWDREKERD-RDNQDREE-NDKDPERERDRERDVDRE------DRFRRPRD 1244
Query: 1373 RDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMD-KDLGSVQGFEETN 1431
R + + S + ++ + +RD RD +ER D +D +G +
Sbjct: 1245 EGGWRRGPAEESSSWR--DSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRS 1302
Query: 1432 KSERTESLEAGDD 1444
+ E S DD
Sbjct: 1303 EREEVSSWRRADD 1315
Score = 57.8 bits (138), Expect = 8e-08
Identities = 69/241 (28%), Positives = 92/241 (38%), Gaps = 42/241 (17%)
Query: 1207 RSPSNDSAHRSGDDQSG---RKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRST 1263
R +D R GDD R V G R++EK + R+SR + + + +
Sbjct: 1150 RRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKER 1209
Query: 1264 SSDRQD--------SRSHSSRRSSPESDRQVHSRSG----------SFDSRDRLQERDRY 1305
D QD R R DR R S RD + DR
Sbjct: 1210 DRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRD 1269
Query: 1306 EHDRERER-ERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERE---- 1360
DR RER +RRD R+R RD D+D R E R D R+D DR E
Sbjct: 1270 RDDRRRERDDRRDLRERRDLRD-DRDRRGPPLRSEREEVSSWRRADDRKD-DRVEERDPP 1327
Query: 1361 -RLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDK 1419
R+ ++ RDR+RDRDR E + ++ R E R+SL K D+
Sbjct: 1328 RRVPPPALSRDRERDRDREREGEKEKASWRAE-------------KDRESLRRTKNETDE 1374
Query: 1420 D 1420
D
Sbjct: 1375 D 1375
Score = 51.2 bits (121), Expect = 8e-06
Identities = 60/232 (25%), Positives = 103/232 (44%), Gaps = 32/232 (13%)
Query: 1246 ERKSRIDQLKRGEPSRSTSS--DRQDSRSHSSRRSSPESDRQVH------SRSGSFDSR- 1296
+R +D ++ E R T+ +R+ + H +R S DR + +R ++ +
Sbjct: 717 QRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKL 776
Query: 1297 ----DRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRER-ERER-ERD 1350
+RL E +R+ ER+R+R++ R+ + R+ +++ R + L+ER ERER ER
Sbjct: 777 KQFEERLAE-ERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERA 835
Query: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH---------ERD 1401
KR + RE + + E +R + R R E + E + E +L +RD
Sbjct: 836 KREEELREYQERVKKLEEVER-KKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRD 894
Query: 1402 LESTSRDSLALDKE----RMDKDLGSVQGFEETNKSERTES--LEAGDDESK 1447
E T R D E +K+ +G +E R E GDDE +
Sbjct: 895 SEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDR 946
Score = 49.7 bits (117), Expect = 2e-05
Identities = 69/331 (20%), Positives = 119/331 (35%), Gaps = 37/331 (11%)
Query: 1166 EKVETPHVTIEDAQHRKPMDQK-RSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGR 1224
E+ E +T + K ++ K R S + +R R + + +++
Sbjct: 726 EQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAE 785
Query: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
+R R R++ + IT R+ ++ +R E + ++ + R +
Sbjct: 786 ERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQ 845
Query: 1285 QVHSRSGSFDSRDRLQERDRYEHDRERERERR------DTRQREW-DRDAD--------- 1328
+ + + + R +E + E +R RE ERR + W DRD++
Sbjct: 846 ERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEA 905
Query: 1329 ----------KDWPRNRDRDRLRERERERERDKRRDLDRERE---RLISDSVERDRDRDR 1375
K+W R RD R R+ ER +R D +RE R D V R R D
Sbjct: 906 DSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPR-RGMDD 964
Query: 1376 DR-TFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER-----MDKDLGSVQGFEE 1429
DR + + R A + R+ + D++R D D +G +E
Sbjct: 965 DRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDE 1024
Query: 1430 TNKSERTESLEAGDDESKLDDAHSLGSGAGE 1460
S RT + G DD GA +
Sbjct: 1025 DRGSWRTADEDRGPRRGMDDDRGPRRGGADD 1055
Score = 41.2 bits (95), Expect = 0.008
Identities = 34/153 (22%), Positives = 65/153 (42%), Gaps = 19/153 (12%)
Query: 1301 ERDRYEHDRERER----ERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLD 1356
+ R EH R R E R R + +K+ R+ + + R+ E ER ++ +
Sbjct: 559 KNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKE 618
Query: 1357 RERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER 1416
RE+ER++ + + + R+R +E +K+ E + + D+E D E
Sbjct: 619 REKERILQEHEQIKKKTVRER------LEQIKKTELGAKAFKDIDIE---------DLEE 663
Query: 1417 MDKDLGSVQGFEETNKSERTESLEAGDDESKLD 1449
+D D + E+ K ++ + E K+D
Sbjct: 664 LDPDFIMAKQVEQLEKEKKELQERLKNQEKKID 696
Score = 37.0 bits (84), Expect = 0.15
Identities = 56/239 (23%), Positives = 98/239 (41%), Gaps = 32/239 (13%)
Query: 1281 ESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRL 1340
++ R+ H R R ++ER +RE+ + QRE + + R R
Sbjct: 559 KNSRKEHQRI--LARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEA 616
Query: 1341 RERERERERDKRRDLDRE--RERL-----------------ISDSVERDRDRDRDRTFES 1381
+ERE+ER + + ++ RERL I D E D D + E
Sbjct: 617 KEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQ 676
Query: 1382 SQIES------VKRCEAKLE-GEHERDLESTSRDSLALDKERM-DKDLGSVQGFEE--TN 1431
+ E +K E K++ E + LE A +++R+ D DL Q E T
Sbjct: 677 LEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTM 736
Query: 1432 KSERTESLEAGDDESK-LDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
+ ER ++LE + S+ L+D + + +++L + AE+R ++ +E K
Sbjct: 737 QLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERK 795
Score = 31.2 bits (69), Expect = 8.2
Identities = 22/90 (24%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
++ E G RE ++ ++ D E ++ + K+ R R RE++ + + R P
Sbjct: 1183 KAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRP 1242
Query: 136 ESE--------EENVEW--ETNRDDSDNGD 155
E EE+ W + RDD D D
Sbjct: 1243 RDEGGWRRGPAEESSSWRDSSRRDDRDRDD 1272
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 148 bits (373), Expect = 5e-35
Identities = 243/1169 (20%), Positives = 415/1169 (35%), Gaps = 120/1169 (10%)
Query: 118 RGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQREL 177
RGR E+ D K EEE E N DI D+ + +E++ +++ +
Sbjct: 27 RGRRGERPDYK--------GEEELRRLEAALVKRPNPDI-LDHERKRRVELRCLELEEMM 77
Query: 178 MKLEQENMEKREEI------IIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSAS 231
+ E + +E++ +++K+V+P P++ ++ + + +
Sbjct: 78 EEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRA 137
Query: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGK---KYKEKYKVKD 288
S V D QR ++ ++K+ P P P + E + K K+K K KD
Sbjct: 138 AFGISDSYVDGSSFDPQRRAR--EAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKD 195
Query: 289 RIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPS 348
R R R + ++K+ + S S +H SP S + + +P+
Sbjct: 196 RGRRSESSSPRRERK-KSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPA 254
Query: 349 PRRKR----TPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR-----SPMREKG 399
P+ +R T + S + T R ++ +H+ + R SP R +P E G
Sbjct: 255 PKSRRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPG 314
Query: 400 RHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP------- 452
+R S ++ + D++KD +E+ S R P
Sbjct: 315 TTSTQRPSSPETAT---KQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLA 371
Query: 453 -RDGRDRR----------------DARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP 495
R G + +A TRDR + + S + ++
Sbjct: 372 ERHGGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVS 431
Query: 496 RDSRSTRDAHDYRDREGRDTHRKEDTYP-EESRSYGRNHLREESSRTEIRNESRNESRSE 554
R + S+ ++ G +HR+ + P ++RS+GR + S T R R+ S +
Sbjct: 432 RHASSSPESPKPAPAPG--SHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPAT 489
Query: 555 IRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPER---DRYPER 611
+ GRSR R P ++G SR Q S + RS P+R R P+R
Sbjct: 490 AKR---GRSRSRTPT--KRGHSRSRSPQWRRSRSAQRWG-----RSRSPQRRGRSRSPQR 539
Query: 612 DNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDR 671
++R++ +RR R R R + P++ R R R R R R
Sbjct: 540 PGWSRSRNT--QRRGRSRSARRGRSHSRSPAT------RGRSRSRTPARRGRSRSRTPAR 591
Query: 672 RDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDR 731
R R+R R R R R R R R R R + R R R R R R R R R R
Sbjct: 592 RRSRSRTPTRRRSRSRTPAR-RGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSR 650
Query: 732 DHDRERERERERDREKEREREREERERERERERERERERER---ERERARERDKERERQR 788
R R R + R R R R R R R R R R R+R R R R R
Sbjct: 651 TPAR-------RGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRTPRRGRSR 703
Query: 789 DWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDS 848
+GR R + R + + R S++R R+ SP ++S R S
Sbjct: 704 SRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLS 763
Query: 849 DAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQ 908
+ + R LS + +S +P + + K + R P R+ S
Sbjct: 764 SPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPP 823
Query: 909 ELKEKVSSVDKQREQT---EILESSRMRAQDIIGHHQSEDRETSD-RAHDENKKKAKIQK 964
+ K K S + ++ + R I +E T R+ E+ +++
Sbjct: 824 KQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKS 883
Query: 965 KPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS-KGDSDISDEEAAQ 1023
+ + R T S K K+I R++S G S S
Sbjct: 884 RTPSRHSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTS 943
Query: 1024 QSKKKRGPRTPPITTKE-ELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082
++ +R P + E L+ + D++ K +T P R
Sbjct: 944 RTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPET----------PPR-----QS 988
Query: 1083 HTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSAT 1142
H+ + +P P PP P + + + P + + + S S S+T
Sbjct: 989 HSGSI-----SPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQSCPGSLSLCAGVKSST 1043
Query: 1143 PTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHT 1202
P + ++ + + + +T + + P Q +S + S + RS +
Sbjct: 1044 PPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQT--SPKGGRSRS 1101
Query: 1203 SGRLRSPSNDSAHRSGDDQSGRKRVLHSG 1231
S + ++ S R + +L SG
Sbjct: 1102 SSPVTELASRSPIRQDRGEFSASPMLKSG 1130
Score = 125 bits (314), Expect = 3e-28
Identities = 177/661 (26%), Positives = 234/661 (35%), Gaps = 59/661 (8%)
Query: 203 RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPR 262
RS+ SP L +P+R+ +S S S D+KT A +PL + R+ + + K
Sbjct: 1496 RSRSPSSPELNNKCLTPQRE---RSGSESSVDQKTVA-RTPLGQRSRSGSSQELDVKP-- 1549
Query: 263 TPSPPPPIPEDIALGKKYKEKYKVKDR--------IEEKTRDGKDRGRDFERQREKRDKP 314
+ SP D + K K + ++ R ++ K+R R R E +DKP
Sbjct: 1550 SASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSSP-EVKDKP 1608
Query: 315 RSTSPA--GQHHSPI----SSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLR 368
R+ A G SP + R S+SGSS + PSP + S + PP
Sbjct: 1609 RAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEH---PPKS 1665
Query: 369 RSASPYPSHSLSSPQRKQSPPRHRSP-----MREKGRHDHERTSQSHDRRHERREDTRGK 423
R+A S + ++PPR RS + K R S S R R +
Sbjct: 1666 RTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHR 1725
Query: 424 RDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDR-RELRDSRDMRDSREM 482
R S E E + SSR R PR R R + R L+ SR SR
Sbjct: 1726 RSPSVSSPEPAEKSR---SSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSR----SRSR 1778
Query: 483 RDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE 542
R+ +R T+ S+ST R T R+ S + R+ R+ESSRT
Sbjct: 1779 REKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGG----SGYHSRSPARQESSRTS 1834
Query: 543 IRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSY 602
R R RS RSR R P K SR SR S S S RS
Sbjct: 1835 SR---RRRGRSRTPPTSRKRSRSRTSPAPWKRSR-SRASPATHRRSRSRTPLISRRRS-- 1888
Query: 603 PERDRY-PERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE 661
R R P R ++R S RR R +R R + + P+ + RR
Sbjct: 1889 --RSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRS 1946
Query: 662 ERRVDRVDDRRDER-----ARERDRERERDRERERERERERDREREKERELERERARERE 716
R V RR R R R R R R R R R + R R R
Sbjct: 1947 RSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRS 2006
Query: 717 REREKERDRERDRDRDHDRERERERERDREKEREREREERE---RERERERERERERERE 773
R R R R R R R R R R R+R R R R R R R +
Sbjct: 2007 RSRTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSR-TPRTARGK 2065
Query: 774 RERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPS 833
R R R R D+ R R P + + R SP+
Sbjct: 2066 RSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPT 2125
Query: 834 P 834
P
Sbjct: 2126 P 2126
Score = 117 bits (294), Expect = 7e-26
Identities = 258/1270 (20%), Positives = 413/1270 (32%), Gaps = 216/1270 (17%)
Query: 63 PSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVR---KESSRG 119
P+P S R S + +++ K K++D + ESSSP R K S +
Sbjct: 163 PAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKD------RGRRSESSSPRRERKKSSKKK 216
Query: 120 RHREKEDIKITKER--TPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQREL 177
+HR + + K K R TP+S+ ++ + + R S H +
Sbjct: 217 KHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSR 276
Query: 178 MKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKT 237
+ + + + SP R +P + S +R SSP+++ T
Sbjct: 277 SRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETA--------T 328
Query: 238 SAVSSPLLDQQRNSKTNQSKKKGPRT------PSPPPPIPEDIALGKKYKEKYKVKDRIE 291
SSP D+ ++ K + + P P PP P P L +++
Sbjct: 329 KQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTP---LLAERH----------- 374
Query: 292 EKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRR 351
SP +P+S + S++ + R P
Sbjct: 375 ------------------------GGSPQPLATTPLSQEPVNPPSEASPTRDRSPPKSPE 410
Query: 352 KRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR----SPMREKGRHDHERTS 407
K S S + + P S + S S SP+ +P HR SP + H +
Sbjct: 411 KLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGRAKRD 470
Query: 408 QSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDR 467
+SH RR R R + + + R H R P+ R R R R R
Sbjct: 471 KSHSHTPSRRMG----RSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR 526
Query: 468 RELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESR 527
R R R SR+T+ R +R R GR R T R
Sbjct: 527 SPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSR---TPARRGR 583
Query: 528 SYGRNHLREES-SRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSH 586
S R R S SRT R SR+ + + R GRSR R P +R + S
Sbjct: 584 SRSRTPARRRSRSRTPTRRRSRSRTPA-----RRGRSRSRTPARRRSRTRSPVRRRSRSR 638
Query: 587 SSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIR 646
S R S R R P R R ++R + RR R R +P R
Sbjct: 639 S---------PARRSGRSRSRTPARRGRSRSRTPA--RRGRSRSR-----------TPAR 676
Query: 647 HQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERE 706
GR+ R R R R R R R R R R
Sbjct: 677 RSGRS--------------------RSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSR 716
Query: 707 LERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERER 766
+ R R K + R R R R E ++ R R
Sbjct: 717 TPQRRGRSGSSSERKNKSRTSQR-------------------RSRSNSSPEMKKSRISSR 757
Query: 767 ERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRY 826
R R R + K R R + K++ R R G + K+K R
Sbjct: 758 ---RSRSLSSPRSKAKSRLSLR----RSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRT 810
Query: 827 RNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ 886
S S P +++ +P +++S + H + P++ SP
Sbjct: 811 PPRRSRSSSSPPPKQKSKTPSRQSHSS----SSPHPKVKSGTPPRQGSITSP-------- 858
Query: 887 GRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDR 946
+ E+ P+R+ + ELK + S + SS R + QS R
Sbjct: 859 -QANEQSVTPQRRSCFESSPDPELKSRTPS------RHSCSGSSPPRVKSSTPPRQSPSR 911
Query: 947 ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEK- 1005
+S + K KA I + R TT + SP + + + +
Sbjct: 912 SSS----PQPKVKAIISPRQRSHSGSSSPSPSRVTSRTTPRRSRSVSPCSNVESRLLPRY 967
Query: 1006 -KRKKSKGDSDISDEEAAQQSKK-------KRGPRTPP-------------ITTKEELVE 1044
S D+ + E +QS K +TPP +K+ LV+
Sbjct: 968 SHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTPPGPSLSGSKSPCPQEKSKDSLVQ 1027
Query: 1045 MCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTE-VTEAEHTATATTP----GSTPSPLSS 1099
C G + + S + + + + T +H + ++P + SP
Sbjct: 1028 SCPGSLSLCAGVKSSTPPGESYFGVSSLQLKGQSQTSPDHRSDTSSPEVRQSHSESPSLQ 1087
Query: 1100 LLPPPPPVATATATTVPATLAATTAAAAT---SFSTSAIT---ISTSATPTNTTNNTFAN 1153
P + ++ P T A+ + FS S + +S + + ++++
Sbjct: 1088 SKSQTSPKGGRSRSSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPT 1147
Query: 1154 EDSHRKCHRTRVEKVETPHVTI----EDAQHRKPMDQKRSSSLGSNRSNRSHT--SGRLR 1207
DS+ ++R+E E+ EDA P + + S S LR
Sbjct: 1148 VDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLR 1207
Query: 1208 SPSND-SAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRI-----DQLKRGEPSR 1261
+P + S S + + L + S+D E + +E + E +I +LK S
Sbjct: 1208 TPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSN 1267
Query: 1262 STSSDRQDSR 1271
SS + R
Sbjct: 1268 FESSPEVEER 1277
Score = 117 bits (293), Expect = 9e-26
Identities = 253/1178 (21%), Positives = 399/1178 (33%), Gaps = 201/1178 (17%)
Query: 82 TGDLRERMK-NKRQDVDTEPQKRNTEESSSPVR---------KESSRGRHREKEDIKITK 131
T + +E+M ++D P ++ + S PV+ K++ R RE+
Sbjct: 1161 TAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLRTPPRERSGAG--- 1217
Query: 132 ERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQ---KIQRELMKLEQENMEKR 188
+PE++E+N T+ D + + V E S E Q + EL ++ N E
Sbjct: 1218 -SSPETKEQNSALPTSSQDEELME-----VVEKSEEPAGQILSHLSSELKEMSTSNFESS 1271
Query: 189 EEIIIKKEVS-----------------PEVVRSKLSP--SPSLRKSSKSPKRKSSPKS-- 227
E+ + VS P + S P SP ++ S SP R++S S
Sbjct: 1272 PEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSFGSPL 1331
Query: 228 ----------------SSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIP 271
SS K+D ++ D + K ++ G + P
Sbjct: 1332 EFRNSGPLGTEMNTGFSSEVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSSELSPDAV 1391
Query: 272 EDIALGKKYKEKYKVKDRI------EEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325
E + V D + E + +D + R +SP + S
Sbjct: 1392 EKAGMSSNQSISSPVLDAVPRTPSRERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGS 1451
Query: 326 PISSRHHSSSSQSGSSIQRHSPSPRRKR---TPSP-SYQRTLTPPLRRSASPYPSHSLSS 381
SRH S S G +PS R +P P + +T P R +SP ++ +
Sbjct: 1452 GTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLT 1511
Query: 382 PQRKQSPPRH--------RSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREE 433
PQR++S R+P+ ++ R +SQ D + R + D DS+ +
Sbjct: 1512 PQRERSGSESSVDQKTVARTPLGQRSRSG---SSQELDVKPSASPQERSESDSSPDSKAK 1568
Query: 434 REYEQDQSSSRDHRDDREPR-DGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKES 492
Q S R P D + R R +R R + + S + E
Sbjct: 1569 TRTPLRQRS----RSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEP 1624
Query: 493 RDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR-NESRNES 551
+ P R + +GR PE S S + SRT R + S E
Sbjct: 1625 KAPAPRALPRRSRSGSSSKGRGPS------PEGSSSTESSPEHPPKSRTARRGSRSSPEP 1678
Query: 552 RSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRY-PE 610
+++ R RS PEL K +R SR S+ S S ETRS P R R P
Sbjct: 1679 KTKSRTPPRRRSSRSSPELTRK-ARLSRRSRSASSSP--------ETRSRTPPRHRRSPS 1729
Query: 611 RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDD 670
+ + A S RR + +R SP + L+R R R R
Sbjct: 1730 VSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSP---SPKPRGLQRSRSRSRREKTRTTR 1786
Query: 671 RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRD 730
RRD + R R R R R R R R R AR+ R R R R
Sbjct: 1787 RRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHS--RSPARQESSRTSSRRRRGRSRT 1844
Query: 731 RDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW 790
R+R R R +R R R R R R R R R R+R R R R
Sbjct: 1845 PPTSRKRSRSRTSPAPWKRSRSRASPATHR-RSRSRTPLISRRRSRSRTSPVSRRRSRSR 1903
Query: 791 EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA 850
+ R R R R+ R+S+ R +P+ R +R R +P
Sbjct: 1904 TSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSR-----TPTTR---RRSRSRTPP--- 1952
Query: 851 YNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQEL 910
V + SRS +P + R R+ R +S +
Sbjct: 1953 -----------------VTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSP-VTRRRS 1994
Query: 911 KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK 970
+ + S V ++R ++ +R R++ T ++ + + + + +
Sbjct: 1995 RSRTSPVTRRRSRSRTSPVTRRRSRS----------RTPPAIRRRSRSRTPLLPRK-RSR 2043
Query: 971 KEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEK------KRKKSKGDSDISDEEAAQQ 1024
+ I R + T P+ + K+S+ + +R S SD S
Sbjct: 2044 SRSPLAIRRRSRSRT--------PRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPA 2095
Query: 1025 SKKKRGPRTPPITTKEELVEMCNGKN------------GILE---------DSQKKEDTA 1063
++ G RTPP+ + + + G+LE ++ +
Sbjct: 2096 TRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCRSPGMLEPLGSSRTPMSVLQQAGGS 2155
Query: 1064 FSDWSDEDVPD--RTEVTEAEHTATATTPGSTPSPLSSLLPPPP---------------P 1106
D +PD RT V E H + T L + PPP P
Sbjct: 2156 MMDGPGPRIPDHQRTSVPE-NHAQSRIALALTAISLGTARPPPSMSAAGLAARMSQVPAP 2214
Query: 1107 VATATATTVPATLAATTAAAATSFSTSAITISTSATPT 1144
V + T PA A+ AA++ + + + T A PT
Sbjct: 2215 VPLMSLRTAPAANLASRIPAASAAAMNLASARTPAIPT 2252
Score = 117 bits (293), Expect = 9e-26
Identities = 184/729 (25%), Positives = 257/729 (35%), Gaps = 98/729 (13%)
Query: 63 PSPRGK-GYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRH 121
PS R + G S R P+ +D+ P + +E SSP K +
Sbjct: 1435 PSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPR 1494
Query: 122 REKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLE 181
+ R+P S E N + T + + + + D QK +
Sbjct: 1495 --------PRSRSPSSPELNNKCLTPQRERSGSESSVD-----------QKTVARTPLGQ 1535
Query: 182 QENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRK-----SSPKSSSASK-KDR 235
+ +E+ +K SP+ RS+ SP + +++P R+ SSP+ S S+ R
Sbjct: 1536 RSRSGSSQELDVKPSASPQE-RSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPR 1594
Query: 236 KTSAVSSP-LLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKT 294
++ + SSP + D+ R + QS +P P P P + ++
Sbjct: 1595 RSRSGSSPEVKDKPRAAPRAQSGSDS--SPEPKAPAPR----------------ALPRRS 1636
Query: 295 RDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRK-R 353
R G K R SP G S SS H S++ R SP P+ K R
Sbjct: 1637 RSGSS------------SKGRGPSPEGSS-STESSPEHPPKSRTARRGSRSSPEPKTKSR 1683
Query: 354 TPSPSYQRTLTPPLRRSA--SPYPSHSLSSPQ-RKQSPPRHRSPMREKGRHDHERTSQSH 410
TP +P L R A S + SSP+ R ++PPRHR E++ S
Sbjct: 1684 TPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSR 1743
Query: 411 DRRHER--REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRR 468
RR R T +R R S + +S SR R+ RDR + + RR
Sbjct: 1744 RRRSASSPRTKTTSRRGR---SPSPKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Query: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRS 528
R R +R R S SR P S+R + R R GR P SR
Sbjct: 1801 RQRSRSRSRVTRRRRGGSG--YHSRSPARQESSRTSS--RRRRGRSRT------PPTSRK 1850
Query: 529 YGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSS 588
R SRT R+ SR+ R RSR R P + + SR SR S + S
Sbjct: 1851 RSR-------SRTSPAPWKRSRSRASPATHR--RSRSRTPLISRRRSR-SRTSPVSRRRS 1900
Query: 589 NSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQ 648
S + TR R P R ++R RR R R + + P+ +
Sbjct: 1901 RSR---TSVTRRRSRSRAS-PVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRR 1956
Query: 649 GRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELE 708
RR R R R R R R R R R R R + R
Sbjct: 1957 RSRSRTPPVTRRRSR------SRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRT 2010
Query: 709 RERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERER 768
R R R R R R R R R+R R R R R R R +R R
Sbjct: 2011 SPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSLTR 2070
Query: 769 ERERERERA 777
R R+
Sbjct: 2071 SPPAIRRRS 2079
Score = 89.7 bits (221), Expect = 2e-17
Identities = 164/739 (22%), Positives = 251/739 (33%), Gaps = 95/739 (12%)
Query: 662 ERRVDRVDDRRDERARERDRERERDRER---ERERERERDREREKERELERERARERERE 718
+R + V RR ER + E R E +R D ER++ EL R E E
Sbjct: 20 QRNLSLVRGRRGERPDYKGEEELRRLEAALVKRPNPDILDHERKRRVEL---RCLELEEM 76
Query: 719 REKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR 778
E++ E+ R E+D + E + + E++ ER R
Sbjct: 77 MEEQGYEEQQIQEKVATFRLMLLEKDVNPGGKEETPGQRPAVTETHQLAELNEKKNERLR 136
Query: 779 ERDKERERQRDWEDKDKGRDDRREKREE---------IREDRNPRDGHDERKSKKRYRNE 829
+ D D R R K+ +RE + R ++K KK+ ++
Sbjct: 137 AAFGISDSYVDGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDR 196
Query: 830 GSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRW 889
G S SP+R R+ S K +KHR ES S H + + +
Sbjct: 197 GRRSESSSPRRERKKS----------SKKKKHR--------SESESKKRKHRSPTPKSKR 238
Query: 890 KEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETS 949
K +D+K +R S+ + + +S D ++SR R+ R +
Sbjct: 239 KSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSS----DTSRSRS-----------RSAA 283
Query: 950 DRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKK 1009
+ H ++ + D E G T + K+ + K KK
Sbjct: 284 AKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKK 343
Query: 1010 SKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSD 1069
K + + + GP P T L E G + A + S
Sbjct: 344 EKS----ATRPSPSPERSSTGPEPPAPTPL--LAERHGGS---------PQPLATTPLSQ 388
Query: 1070 EDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATS 1129
E V +E + + +P P SS PP P T + ++ + A A
Sbjct: 389 EPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPG 448
Query: 1130 FSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRS 1189
S IS+S T N ++ + SH R+ + R P KR
Sbjct: 449 ---SHREISSSPTSKNRSHGRAKRDKSHSHTPSRRM------------GRSRSPATAKRG 493
Query: 1190 SSLGSNRSNRSHTSGRLRSPS---NDSAHRSGDDQSGRKRVLHSGSRDREKTK---SLEI 1243
S + R H+ R RSP + SA R G +S ++R R R + S
Sbjct: 494 RSRSRTPTKRGHS--RSRSPQWRRSRSAQRWGRSRSPQRR-----GRSRSPQRPGWSRSR 546
Query: 1244 TGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERD 1303
+R+ R +RG + + R SRS + R R R + R + R
Sbjct: 547 NTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRSRTPARRRSRSRTPTRRRSRS 606
Query: 1304 RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR-RDLDR---ER 1359
R R R R R R+R R + R+R R R R R +R R R R
Sbjct: 607 RTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPARR 666
Query: 1360 ERLISDSVERDRDRDRDRT 1378
R S + R R R RT
Sbjct: 667 GRSRSRTPARRSGRSRSRT 685
Score = 83.6 bits (205), Expect = 1e-15
Identities = 227/1116 (20%), Positives = 381/1116 (34%), Gaps = 177/1116 (15%)
Query: 194 KKEVSPEVVRSKLSPSPSLRKSSKSPKRK------SSP--KSSSASKKDRKTSAVSS-PL 244
K + SP+ RS+ S SP +S+SP R+ +SP KS + ++ R S SS P
Sbjct: 1089 KSQTSPKGGRSR-SSSPVTELASRSPIRQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPT 1147
Query: 245 LDQ-----QRNSKTNQSKKKGPRTP----SPPPPIPED----IALGKKYKEKYKVKDRIE 291
+D Q +T +SK+K P + PP +D + + + KD +
Sbjct: 1148 VDSNSLLGQSRLETAESKEKMALPPQEDATASPPRQKDKFSPFPVQDRPESSLVFKDTLR 1207
Query: 292 EKTRDGKDRGRDFERQREKRDKP-------------RSTSPAGQHHSPISSRHHSSSSQS 338
R+ G E + + P +S PAGQ S +SS S+ +
Sbjct: 1208 TPPRERSGAGSSPETKEQNSALPTSSQDEELMEVVEKSEEPAGQILSHLSSELKEMSTSN 1267
Query: 339 GSSI----QRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRS- 393
S +R + S ++ S + + P S+ P S + SP R S
Sbjct: 1268 FESSPEVEERPAVSLTLDQSQSQASLEAVEVPSMASSWGGPHFSPEHKELSNSPLRENSF 1327
Query: 394 ----PMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDD 449
R G E + E +ED G + ++ + ++ + S H
Sbjct: 1328 GSPLEFRNSGPLGTEMNTGFSS---EVKEDLNGPFLNQLETDPSLDMKEQSTRSSGHSSS 1384
Query: 450 REPRDGRDRRDARDTRD-RRELRDSRDMRDSREMRDYSRDTKESRD--PRD-SRSTRDAH 505
D ++ + + D+ SRE R S + E +D PR SR +R
Sbjct: 1385 ELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRE-RSSSASSPEMKDGLPRTPSRRSRSGS 1443
Query: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRN-DRMGRSR 564
R+G T P G + ++ RT R S +S E + + R R
Sbjct: 1444 SPGLRDGSGT-------PSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPR 1496
Query: 565 GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER 624
R P PE ++ Q + S S+ R+ +R R D +S +
Sbjct: 1497 SRSPSSPELNNK-CLTPQRERSGSESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQE 1555
Query: 625 RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERE 684
R D++ + + P G + E++ R RR +R
Sbjct: 1556 RSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRR-----------SRSGSSPEV 1604
Query: 685 RDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERD 744
+D+ R R + + + R R + R + E E
Sbjct: 1605 KDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEHPPK 1664
Query: 745 REKEREREREERE-RERERERERERERERERERARE-RDKERERQRDWEDKDKGRDDRRE 802
R R E + + R R R E R+ R R R + + R R
Sbjct: 1665 SRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRTPPRH 1724
Query: 803 KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSD----AYNSGDDKN 858
+R P + KS+ R + SPR RR SP + +
Sbjct: 1725 RRSPSVSSPEPAE-----KSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRSRR 1779
Query: 859 EKHRLL--------SQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQEL 910
EK R SQ + RS S S +T R+G R P R+ESSR
Sbjct: 1780 EKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSR------- 1832
Query: 911 KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK 970
+S ++R ++ +SR R++ TS ++ +A +
Sbjct: 1833 ----TSSRRRRGRSRTPPTSRKRSRS----------RTSPAPWKRSRSRASPATHRRSRS 1878
Query: 971 KEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG 1030
+ + R T+ S ++ + + S+ ++R +S+ A+ S+++
Sbjct: 1879 RTPLISRRRSRSRTSP-----VSRRRSRSRTSVTRRRSRSR---------ASPVSRRRSR 1924
Query: 1031 PRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTP 1090
RTPP+T + R+ + + TP
Sbjct: 1925 SRTPPVTRRR---------------------------------SRSRTPTTRRRSRSRTP 1951
Query: 1091 GSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNT 1150
T S PPV + + + + + + TS T + S ++ T + +
Sbjct: 1952 PVTRRRSRS---RTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRS 2008
Query: 1151 FANEDSHRKCH-RT-----RVEKVETPHVTIEDAQHRKPMDQKRSS-------SLGSNRS 1197
+ + R+ RT R + TP + + ++ R P+ +R S + G
Sbjct: 2009 RTSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSRTPRTARGKRSL 2068
Query: 1198 NRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSR 1233
RS + R RS S S+ RS R HSGSR
Sbjct: 2069 TRSPPAIRRRSASGSSSDRSRSATPPATR-NHSGSR 2103
Score = 68.6 bits (166), Expect = 5e-11
Identities = 70/241 (29%), Positives = 90/241 (37%), Gaps = 18/241 (7%)
Query: 206 LSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPS 265
L P+ R SS S SS SSS+S +S SS D + +S Q + R PS
Sbjct: 2524 LQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS--DSEGSSLPVQPEVALKRVPS 2581
Query: 266 PPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHS 325
P P E + G R E T + R S+S + S
Sbjct: 2582 PTPAPKEAVREG-----------RPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSS 2630
Query: 326 PISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASP-YPSHSL-SSPQ 383
SS SSSS S SS P + P P+ + P RRS SP P SL S
Sbjct: 2631 SSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRS 2690
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRG---KRDREKDSREEREYEQDQ 440
SP R P + D + +S R +R D+R KR RE S + +
Sbjct: 2691 LSYSPVERRRPSPQPSPRDQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMRHRSSR 2750
Query: 441 S 441
S
Sbjct: 2751 S 2751
Score = 67.4 bits (163), Expect = 1e-10
Identities = 125/588 (21%), Positives = 209/588 (35%), Gaps = 38/588 (6%)
Query: 822 SKKRYRNEGSPSPRQSPK--RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPS 879
S+ R + SP P+ P+ R R SP S N+ ++ R S+ Q++ + +P
Sbjct: 1474 SRGRSECDSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTPL 1533
Query: 880 HLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIG 939
R G +E D KP R + K + R+++ S + ++ +
Sbjct: 1534 G-QRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLS 1592
Query: 940 HHQSEDR---ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKK 996
+S E D+ + ++ P + K + R + +S G+ SP+
Sbjct: 1593 PRRSRSGSSPEVKDKPRAAPRAQSGSDSSP-EPKAPAPRALPRRSRSGSSSKGRGPSPEG 1651
Query: 997 GQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPR------TPPITTKEELVEMCNGKN 1050
+S + KS+ S ++K + PR +P +T K L +
Sbjct: 1652 SSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSAS 1711
Query: 1051 GILEDSQK---KEDTAFSDWSDEDVPD-----RTEVTEAEHTATATTPGSTPSPLSSLLP 1102
E + + + S S E R + T T + G +PSP L
Sbjct: 1712 SSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQ 1771
Query: 1103 PPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTF-----ANEDSH 1157
+ T + ++ +TS + T + + A ++S
Sbjct: 1772 RSRSRSRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESS 1831
Query: 1158 RKCHRTRVEKVETPHVTIEDAQHR-KPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHR 1216
R R R + TP + + ++ R P KRS S S ++R S S R
Sbjct: 1832 RTSSRRRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSR 1891
Query: 1217 SGDDQSGRKRVLHSGSRDREKTKSLEITGER-KSRIDQLKRGEPSRSTSSDRQDSRSH-- 1273
+ R R S +R R ++++ ++ R +SR + R T + R+ SRS
Sbjct: 1892 TSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTP 1951
Query: 1274 ------SSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDA 1327
S R+ P + R+ SR+ R R R R TR+R R
Sbjct: 1952 PVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRR--SRSR 2009
Query: 1328 DKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDR 1375
R R R R R R R + L R+R R S R R R R
Sbjct: 2010 TSPVTRRRSRSRTPPAIRRRSRSRTPLLPRKRSRSRSPLAIRRRSRSR 2057
Score = 67.0 bits (162), Expect = 1e-10
Identities = 132/719 (18%), Positives = 238/719 (33%), Gaps = 77/719 (10%)
Query: 620 SSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARER 679
SSF+ + R+ + +P S +R + +++++++ DR RR E + R
Sbjct: 149 SSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDR--GRRSESSSPR 206
Query: 680 DRERERDRERERERERERDREREKERELERERAREREREREKERD-------RERDRDRD 732
RER++ ++++ R ++R+ + + + ++++R++ R R R
Sbjct: 207 -RERKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTS 265
Query: 733 HDRERERERERDREKEREREREE-------------RERERERERERERERERERERARE 779
D + R R + + R E + +R + E
Sbjct: 266 ADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPE 325
Query: 780 RDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKK-RYRNEGSPSP-RQS 837
++ +EDKDK + ++ R +R+ + R+ GSP P +
Sbjct: 326 T-ATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATT 384
Query: 838 PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE 897
P + +P S+A + D K ES SP R E KP
Sbjct: 385 PLSQEPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPA 444
Query: 898 RKESSRRYEEQELKEKVSSV-----DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRA 952
S R K S DK T R R+ +S R + R
Sbjct: 445 PAPGSHREISSSPTSKNRSHGRAKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRG 504
Query: 953 HDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKG 1012
H ++ + + ++ RG + G S ++ +S +R +S
Sbjct: 505 HSRSRSPQWRRSRSAQRWGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHS 564
Query: 1013 DSDISDEEAAQQSKKKRG---PRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSD 1069
S + + ++ +RG RTP + + T S
Sbjct: 565 RSPATRGRSRSRTPARRGRSRSRTPA-------------------RRRSRSRTPTRRRSR 605
Query: 1070 EDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATS 1129
P R + + A + +P S P + + + PA + +
Sbjct: 606 SRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRSPARRSGRSRSRTPARRGRSRSRTPAR 665
Query: 1130 FSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEK---VETPHVTIEDAQHRKPMDQ 1186
S S TP + + + + R R+R + + + H + +
Sbjct: 666 RGRSR-----SRTPARRSGRSRSRTPARRGRSRSRTPRRGRSRSRSLVRRGRSHSRTPQR 720
Query: 1187 KRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKT-------- 1238
+ S S R N+S TS R RS SN S S R+ S R + K+
Sbjct: 721 RGRSGSSSERKNKSRTSQR-RSRSNSSPEMKKSRISSRRSRSLSSPRSKAKSRLSLRRSL 779
Query: 1239 -------KSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRS 1290
K T R+SR + SR+ + S S ++ S RQ HS S
Sbjct: 780 SGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSS 838
Score = 64.7 bits (156), Expect = 7e-10
Identities = 138/592 (23%), Positives = 205/592 (34%), Gaps = 112/592 (18%)
Query: 62 GPSPRGKGYSSNYRRSPERPTGDLRERMKNK-----RQDVDTEPQKRNTEESSSPVRKES 116
GPSP G SS+ SPE P R ++ + T P++R++ S RK
Sbjct: 1646 GPSPEG---SSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKAR 1702
Query: 117 SRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRE 176
R R T+ RTP + + E + + + + +R
Sbjct: 1703 LSRRSRSASSSPETRSRTPPRHRRSPSVSS---------------PEPAEKSRSSRRRRS 1747
Query: 177 LMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
+ +R SPSP R +S R K+ + ++DR
Sbjct: 1748 ASSPRTKTTSRRGR----------------SPSPKPRGLQRSRSRSRREKTRTTRRRDRS 1791
Query: 237 TSAVSSPLLDQQRNSKTNQSKKK--GPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKT 294
S+ S+ Q+ S++ ++++ G S P E R +
Sbjct: 1792 GSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQE--------------SSRTSSRR 1837
Query: 295 RDGKDRGRDFERQRE---------KRDKPRSTSPAGQHHS----PISSRHHSSSSQSGSS 341
R G+ R R+R KR + R+ SPA S P+ SR S S S S
Sbjct: 1838 RRGRSRTPPTSRKRSRSRTSPAPWKRSRSRA-SPATHRRSRSRTPLISRRRSRSRTSPVS 1896
Query: 342 IQRH----SPSPRRKRT----PSPSYQRTLTPPL--RRSASPYPSHSLSSPQRKQSPPRH 391
+R S + RR R+ S R+ TPP+ RRS S P+ S R R
Sbjct: 1897 RRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRTPPVTRR 1956
Query: 392 RSPMRE---KGRHDHERTSQSHDRR-HERREDTRGKRDREKDSREEREYEQDQSSSRDHR 447
RS R R RTS RR R +R R + S R + ++S R
Sbjct: 1957 RSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRR 2016
Query: 448 DDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD---- 503
R RR +R + SR R +R SR SR PR +R R
Sbjct: 2017 RSRSRTPPAIRRRSRSRTPLLPRKRSRS-RSPLAIRRRSR----SRTPRTARGKRSLTRS 2071
Query: 504 --AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES---------SRTEIRNESRNESR 552
A R G + R P +R++ + + SR + + R
Sbjct: 2072 PPAIRRRSASGSSSDRSRSATPPATRNHSGSRTPPVALNSSRMSCFSRPSMSPTPLDRCR 2131
Query: 553 SEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
S + +G SR + L + G GS +D H R+S PE
Sbjct: 2132 SPGMLEPLGSSRTPMSVLQQAG-----GSMMDGPGPRIPDHQ----RTSVPE 2174
Score = 59.3 bits (142), Expect = 3e-08
Identities = 93/409 (22%), Positives = 153/409 (37%), Gaps = 49/409 (11%)
Query: 60 VHGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRG 119
V P P K SS RRS P R+ P+ R + S S R+E +R
Sbjct: 1730 VSSPEPAEKSRSSRRRRSASSP-----RTKTTSRRGRSPSPKPRGLQRSRSRSRREKTRT 1784
Query: 120 RHREKEDIKITKERTPESEEENVEWETNRDDS-----DNGDINYDYVHELSLEMKRQKIQ 174
R ++R+ S+ + + +R S G Y E R +
Sbjct: 1785 TRR--------RDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSR 1836
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSP---KRKSSPKSSSAS 231
R + ++ + RS+ SP+ R S++P +R+S ++S S
Sbjct: 1837 RRRGRSRTPPTSRKRSRSRTSPAPWKRSRSRASPATHRRSRSRTPLISRRRSRSRTSPVS 1896
Query: 232 -KKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRI 290
++ R ++V+ +R S++ S R+ S PP+ + + + + + R
Sbjct: 1897 RRRSRSRTSVT------RRRSRSRASPVSRRRSRSRTPPVTRRRSRSRTPTTRRRSRSRT 1950
Query: 291 EEKT-RDGKDRGRDFERQREK-RDKPRSTSPAGQHHSPIS---SRHHSSSSQSGSSIQRH 345
T R + R R+R + R P + + SP++ SR +S S R
Sbjct: 1951 PPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRT 2010
Query: 346 SPSPRRKRTPSPSYQRTLTPPL--RRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDH 403
SP RR+ R+ TPP RRS S P RK+S R RSP+ + R
Sbjct: 2011 SPVTRRR-------SRSRTPPAIRRRSRSRTP-----LLPRKRS--RSRSPLAIRRRSRS 2056
Query: 404 ERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP 452
+ +R R +R S +R ++R+H R P
Sbjct: 2057 RTPRTARGKRSLTRSPPAIRRRSASGSSSDRSRSATPPATRNHSGSRTP 2105
Score = 53.9 bits (128), Expect = 1e-06
Identities = 60/207 (28%), Positives = 87/207 (42%), Gaps = 30/207 (14%)
Query: 181 EQENMEKREEIIIKKEVSP-----EVVRSKL--SPSPSLRKSSKSPKRKSSPKSSSASKK 233
E ++ + E+ +K+ SP E VR P+P+ RK +R SS SSS+S
Sbjct: 2564 EGSSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRK-----RRSSSSSSSSSSSS 2618
Query: 234 DRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKY----KVKDR 289
+S+ SS +S ++ S +PSP P P+ AL K K + + R
Sbjct: 2619 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQ--ALPKPASPKKPPPGERRSR 2676
Query: 290 IEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSP 349
K D R +R +P S P+ + SS S Q G S SPS
Sbjct: 2677 SPRKPIDSLRDSRSLSYSPVERRRP-SPQPSPRDQQSSSSERGSRRGQRGDS---RSPSH 2732
Query: 350 RRKR-TPSPSYQRTLTPPLRRSASPYP 375
+R+R TPSP P+R +S P
Sbjct: 2733 KRRRETPSPR-------PMRHRSSRSP 2752
Score = 42.4 bits (98), Expect = 0.004
Identities = 51/233 (21%), Positives = 77/233 (33%), Gaps = 17/233 (7%)
Query: 319 PAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHS 378
PA + S SS SSSS S SS S S + S + P + P P+ +
Sbjct: 2526 PAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPA 2585
Query: 379 LSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQ 438
R+ PP +P + K R +S S + S
Sbjct: 2586 PKEAVREGRPPEP-TPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2644
Query: 439 DQSSSRDHR----------DDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRD 488
SS + ++P G +RR + LRDSR + S R
Sbjct: 2645 SSSSPSPAKPGPQALPKPASPKKPPPG-ERRSRSPRKPIDSLRDSRSLSYSPVERRRPSP 2703
Query: 489 TKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRT 541
RD + S S R + R G+ + ++ + +R SSR+
Sbjct: 2704 QPSPRDQQSSSSERGS-----RRGQRGDSRSPSHKRRRETPSPRPMRHRSSRS 2751
Score = 41.2 bits (95), Expect = 0.008
Identities = 65/337 (19%), Positives = 134/337 (39%), Gaps = 34/337 (10%)
Query: 929 SSRMR---AQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985
SSRM +Q ++ Q + R A + + Q P+ + + G + TT
Sbjct: 2428 SSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIAQTTPVAGSQS----LSSGAVATT 2483
Query: 986 SE-----DGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKE 1040
+ +G + P G + + S G S A Q +K++R + ++
Sbjct: 2484 TSSAGDHNGMLSVPAPGVPHSDVGEP-PASTGAQQPSALAALQPAKERRSSSSSSSSSSS 2542
Query: 1041 ELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSL 1100
+ + S ++ SD +P + EV A P TP+P ++
Sbjct: 2543 ------SSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEV------ALKRVPSPTPAPKEAV 2590
Query: 1101 L----PPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDS 1156
P P P ++ ++ +++++++++S S+S+ + S+S++ +++++++ ++ S
Sbjct: 2591 REGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPS 2650
Query: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHR 1216
K + K +P + R +K SL +RS S++ R PS + R
Sbjct: 2651 PAKPGPQALPKPASPKKP-PPGERRSRSPRKPIDSLRDSRS-LSYSPVERRRPSPQPSPR 2708
Query: 1217 ---SGDDQSGRKRVLHSGSRDREKTKSLEITGERKSR 1250
S + G +R SR + E R R
Sbjct: 2709 DQQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPMR 2745
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 146 bits (368), Expect = 2e-34
Identities = 158/646 (24%), Positives = 270/646 (41%), Gaps = 105/646 (16%)
Query: 330 RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPP 389
RH SSSS S SS S S S S S +S
Sbjct: 190 RHKSSSSSSSSSSDSDSSSD--------------------------SQSSSDSSDSESAT 223
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDD 449
+S R+K H + S+ H + ++R+ + K+ +S E Q QS+ R
Sbjct: 224 EEKSKKRKK---KHRKNSRKHKKEKKKRK--KSKKSASSESEAENLEAQPQSTVRPEEIP 278
Query: 450 REP------RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
P R + D ++ ++R R+ + + Y R +R R + R
Sbjct: 279 PIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKG-RG 337
Query: 504 AHDYRD---REGRDTHRKEDTYPEESRSYGR-NHLREESSRTEIR------NESRNESRS 553
YR RD R+ +T P + R +R S I+ NE + RS
Sbjct: 338 PRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRS 397
Query: 554 EIR-NDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERD 612
+R +R V E P + + + ++ H SNS D R + + D+Y +
Sbjct: 398 PVRVKERKITDHRNVSESPNR--KNEKEKKVKDHKSNSKERD---IRRNSEKDDKYKNKV 452
Query: 613 NR---DQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRV 668
+ ++R S E+ + ERD + NR ++R S R +GR+ E ++ +E++ +
Sbjct: 453 KKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRS--RSKGRDHENVKE--KEKQSDSKG 508
Query: 669 DDRRDERARERDRERE-RDRERERERERERDRERE-KERELERERAREREREREKERDRE 726
D+ R++E+ ++ E + E + + +E+DR + + RE + + + R +ER R
Sbjct: 509 KDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRS 568
Query: 727 RDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERER 786
RDR R R R R +RDR + +E R + R R R R RER R+R +D+ R R
Sbjct: 569 RDRSR---RVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRR 625
Query: 787 QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
RD R +REE + RN +D + ++SK +R E S S ++ + R+H
Sbjct: 626 ----------RDSRSSEREE-SQSRN-KDKYRNQESKSSHRKENSESEKRMYSKSRDH-- 671
Query: 847 DSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
NS ++ EK + R SP + K+ + E K S + +
Sbjct: 672 -----NSSNNSREK----------KADRDQSPF-------SKIKQSSQDNELKSSMLKNK 709
Query: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRA 952
E E SSV+K+ ++++ E+ + ++ H+S D++
Sbjct: 710 EDEKIR--SSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKS 753
Score = 140 bits (353), Expect = 1e-32
Identities = 153/695 (22%), Positives = 281/695 (40%), Gaps = 103/695 (14%)
Query: 116 SSRGRHREKEDIKITKERTPESEEENVEW-----------ETNRDDSDNGDINYDYVHEL 164
++RG+ IT + TP + +V + E +D + V L
Sbjct: 113 ANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRIL 172
Query: 165 SLE--MKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRK 222
S + + K+++E K + + S S S S S + ++K
Sbjct: 173 SCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKK 232
Query: 223 SSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKE 282
K+S KK++K S + ++ +++ + P PPIPE+ L +K
Sbjct: 233 KHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPP 292
Query: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI 342
K K+R ++ ER+RE+ P ++ PA + +R SG I
Sbjct: 293 KADEKER------------KNRERERERECNPPNSQPASYQRRLLVTR-------SGRKI 333
Query: 343 QRHSPSPRRKRTPSPS-----YQRTLTPP-LRRSASPYPSHSLSSPQR---------KQS 387
+ PRR RTPS S ++R+ TPP R+ +SS +R +
Sbjct: 334 K--GRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEI 391
Query: 388 PPRHRSPMREKGRH--DHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445
RSP+R K R DH S+S +R++E+ + + + K+ R E
Sbjct: 392 KENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE-------- 443
Query: 446 HRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH 505
+DD+ + R ++ +E S++ RDS+ R+ + + RD + ++
Sbjct: 444 -KDDKYKNKVKKRAKSKSRSKSKEKSKSKE-RDSKHNRNEEKRMRSRSKGRDHENVKEKE 501
Query: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565
D +G+D E SRS +E+S + E ++ + S+S+ DR +SR
Sbjct: 502 KQSDSKGKD--------QERSRS------KEKSKQLESKSNEHDHSKSK-EKDRRAQSRS 546
Query: 566 RVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERR 625
R ++ + HS NS + +RS R +RD++R + R
Sbjct: 547 RECDITK-----------GKHSYNSRTRE--RSRSRDRSRRVRSRTHDRDRSRSKEYHRY 593
Query: 626 HGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERER 685
+ RR R R + +P GR+ +R R RR R +R + ++R +D+ R +
Sbjct: 594 REQEYRRRGRSRSRERRTP---PGRSRSKDRRRR---RRDSRSSEREESQSRNKDKYRNQ 647
Query: 686 DRERERERERERDREREKERELERERAREREREREKERDRERD-----RDRDHDRERERE 740
+ + R+ + E EK + REK+ DR++ + D E +
Sbjct: 648 E---SKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSS 704
Query: 741 RERDREKEREREREERERERERERERERERERERE 775
+++E E+ R E+E ++ + +E + E+ ++
Sbjct: 705 MLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKK 739
Score = 135 bits (339), Expect = 4e-31
Identities = 150/665 (22%), Positives = 273/665 (41%), Gaps = 101/665 (15%)
Query: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTP 264
+L P ++K K + SS SSS+S D + + SS ++ +SKK+
Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKR----- 230
Query: 265 SPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHH 324
KK K K + E+K R + E + E + ++ +
Sbjct: 231 -------------KKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEI 277
Query: 325 SPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQR 384
PI + ++ + R+R +R PP + AS ++ R
Sbjct: 278 PPIPENRFLMRKSPPKADEKERKNRERER------ERECNPPNSQPASYQRRLLVTRSGR 331
Query: 385 K---QSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQS 441
K + P R+R+P R + R +R +S H R+E R +R R S ER + D+S
Sbjct: 332 KIKGRGPRRYRTPSRSRSR---DRFRRSETPPHWRQEMQRAQRMRV--SSGERWIKGDKS 386
Query: 442 SSRDHRDD-REPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500
+ +++ R P ++R+ D R + +S + ++ +E K+ +D + +
Sbjct: 387 ELNEIKENQRSPVRVKERK----ITDHRNVSESPNRKNEKE--------KKVKDHKSNSK 434
Query: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
RD R K+D Y + + + ++++ R++S+ +S+S+ R+ +
Sbjct: 435 ERDI--------RRNSEKDDKYKNKVK---------KRAKSKSRSKSKEKSKSKERDSKH 477
Query: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
R+ EK R S S ++ + E + + ER +R + +
Sbjct: 478 NRNE-------EKRMR--------SRSKGRDHENVKEKEKQSDSKGKDQER-SRSKEKSK 521
Query: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
E + E D ++E+D+R Q R+ E + + + + R ER+R RD
Sbjct: 522 QLESKSNEHDHSKSKEKDRRA------QSRSRECDITKGKHS-----YNSRTRERSRSRD 570
Query: 681 RERERDRERERERERERDREREKERELE-RERARERERERE----KERDRERDRDRDHDR 735
R R R R R +R+R R +E + RE E R R R R RER + R ++R R R R
Sbjct: 571 RSR-RVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSR 629
Query: 736 ERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDK 795
ERE + R K++ R +E + R+ E E+ + + RE++ D +
Sbjct: 630 SSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPF 689
Query: 796 GRDDRREKREEIRED--RNPRD----GHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSD 849
+ + + E++ +N D E++++K E ++ K E SP +D
Sbjct: 690 SKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTD 749
Query: 850 AYNSG 854
SG
Sbjct: 750 EDKSG 754
Score = 134 bits (338), Expect = 5e-31
Identities = 136/596 (22%), Positives = 254/596 (42%), Gaps = 62/596 (10%)
Query: 466 DRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEE 525
+++ + S S D S D++ S D DS S A + + ++ + HRK
Sbjct: 187 EKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSES---ATEEKSKKRKKKHRKNS----- 238
Query: 526 SRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGR---VPELPEKGSRGSRGSQ 582
R H +E+ R + + + +ES +E + +S R +P +PE +
Sbjct: 239 -----RKHKKEKKKRKKSKKSASSESEAE-NLEAQPQSTVRPEEIPPIPENRFLMRKSPP 292
Query: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERD-NRDQARDSSFERR-----HGERDRRDNRE 636
N R+R ER+ N ++ +S++RR G + +
Sbjct: 293 KADEKERKN-------------RERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPR 339
Query: 637 RDQRPS-SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDR-ERERDRERERERE 694
R + PS S R + R E R+E +R R+ ER + D+ E +E +R
Sbjct: 340 RYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPV 399
Query: 695 RERDREREKERELERERARERERERE--------KERDRERDRDRDHDRERERERERDRE 746
R ++R+ R + R+ E+E++ KERD R+ ++D D+ + + ++R +
Sbjct: 400 RVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKD-DKYKNKVKKRAKS 458
Query: 747 KEREREREERERERERERERERERERERERARERD----KERERQRDWEDKDKGRDDRRE 802
K R + +E+ + + + E +R R R++ RD KE+E+Q D + KD+ R +E
Sbjct: 459 KSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKE 518
Query: 803 KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
K +++ N HD KSK++ R S S R+ + +HS +S ++ R
Sbjct: 519 KSKQLESKSNE---HDHSKSKEKDRRAQSRS-RECDITKGKHSYNSRTRERSRSRDRSRR 574
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQRE 922
+ S+ SRS E R + R R + + + S +RE
Sbjct: 575 VRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSERE 634
Query: 923 QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNI 982
+++ + R Q+ H+ E+ E+ R + +++ KK D + I
Sbjct: 635 ESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSK--I 692
Query: 983 ETTSEDGQVFSP----KKGQK-KKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRT 1033
+ +S+D ++ S K+ +K + S+EK+ +KSKG + E ++ + P T
Sbjct: 693 KQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGT 748
Score = 100 bits (249), Expect = 1e-20
Identities = 143/635 (22%), Positives = 245/635 (38%), Gaps = 109/635 (17%)
Query: 97 DTEPQKRNTEESSSPV----RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSD 152
D+ + TEE S RK S + + +K+ K K + ESE EN+E + S
Sbjct: 215 DSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLE---AQPQST 271
Query: 153 NGDINYDYVHELSLEMKRQKIQRELMKLEQENMEK-REEIIIKKEVSPEVVRSKLSPSPS 211
+ E M++ + + + E++N E+ RE P + +L + S
Sbjct: 272 VRPEEIPPIPENRFLMRKSPPKAD--EKERKNRERERERECNPPNSQPASYQRRLLVTRS 329
Query: 212 LRK-SSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPI 270
RK + P+R +P S + +DR + + P Q+ G R I
Sbjct: 330 GRKIKGRGPRRYRTP--SRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERW------I 381
Query: 271 PEDIALGKKYKEKYKVKDRIEE-KTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISS 329
D + + KE + R++E K D ++ R+ EK K + H S
Sbjct: 382 KGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVK------DHKSNSKE 435
Query: 330 RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPP 389
R +S+ + + +KR S S RS S S S +
Sbjct: 436 RDIRRNSEKDDKYK----NKVKKRAKSKS----------RSKSKEKSKSKERDSKHNRNE 481
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDD 449
R R KGR DHE + E++ D++GK S+E+ + + +S+ DH
Sbjct: 482 EKRMRSRSKGR-DHENVKEK-----EKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKS 535
Query: 450 RE-PRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYR 508
+E R + R D + +SR SR RD SR + RD +++ H YR
Sbjct: 536 KEKDRRAQSRSRECDITKGKHSYNSRTRERSRS-RDRSRRVRSRTHDRDRSRSKEYHRYR 594
Query: 509 DRE----GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSR 564
++E GR R+ T P SRS R R +S +E R ES++ ++ + RN
Sbjct: 595 EQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSE-REESQSRNKDKYRNQ------ 647
Query: 565 GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFER 624
+S SS+ + E R RD ++R++ D
Sbjct: 648 -------------------ESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKAD----- 683
Query: 625 RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERE 684
RDQ P S I+ +++EL + + ++ DE+ R
Sbjct: 684 ------------RDQSPFSKIKQSSQDNEL---------KSSMLKNKEDEKIRS-----S 717
Query: 685 RDRERERERERERDREREKERELERERARERERER 719
++E ++ + +E D EK ++ + E + + ++
Sbjct: 718 VEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDK 752
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/317 (24%), Positives = 133/317 (41%), Gaps = 24/317 (7%)
Query: 1147 TNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRL 1206
T++ +E +RK + + K + D + D K + + ++S + +
Sbjct: 407 TDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKE 466
Query: 1207 RSPS--NDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTS 1264
+S S DS H +++ R R S RD E K E + K + + R +
Sbjct: 467 KSKSKERDSKHNRNEEKRMRSR---SKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQL 523
Query: 1265 SDRQDSRSHSSRRSSPESDRQVHSRSGSFD-----------SRDRLQERDRYEHDRERER 1313
+ + HS S E DR+ SRS D +R+R + RDR R R
Sbjct: 524 ESKSNEHDHS---KSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTH 580
Query: 1314 ERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDR 1373
+R +R +E+ R ++++ R R R R RER + R DR R R S S ER+ +
Sbjct: 581 DRDRSRSKEYHRYREQEY---RRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQ 637
Query: 1374 DRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKS 1433
R++ + + + K K E E+ + S SRD + + R K F + +S
Sbjct: 638 SRNK--DKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQS 695
Query: 1434 ERTESLEAGDDESKLDD 1450
+ L++ ++K D+
Sbjct: 696 SQDNELKSSMLKNKEDE 712
Score = 79.3 bits (194), Expect = 3e-14
Identities = 118/627 (18%), Positives = 233/627 (37%), Gaps = 102/627 (16%)
Query: 707 LERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERER 766
+ + + ++ E++R K D D + + D E+ ++ +++ R+
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237
Query: 767 ERERERERERARERDKERERQRDWEDKDKGRDD--RREKREEIREDR------NPRDGHD 818
R+ ++E+++ ++ K + + E+ + R E+ I E+R P+
Sbjct: 238 SRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEK 297
Query: 819 ERKSKKRYRNEGSPSPRQSPK--RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSL 876
ERK+++R R P P +RR S G R + RS
Sbjct: 298 ERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSE 357
Query: 877 SPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQT-----EILESSR 931
+P H ++ Q + ER + E E+KE S + +E+ + ES
Sbjct: 358 TPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPN 417
Query: 932 MR--AQDIIGHHQSEDRETSDRAHDE------NKKKAKIQKKPIKKKKEDDVGIERGNIE 983
+ + + H+S +E R + E NK K + + K K KE ER +
Sbjct: 418 RKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKH 477
Query: 984 TTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELV 1043
+E+ ++ S KG+ +++++K K+S DS D+ ++S+ K
Sbjct: 478 NRNEEKRMRSRSKGRDHENVKEKEKQS--DSKGKDQ---ERSRSKE-------------- 518
Query: 1044 EMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRT---EVTEAEHTATATTPGSTPSPLSSL 1100
K+ LE + D + S D R+ ++T+ +H+ +
Sbjct: 519 -----KSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSR------------ 561
Query: 1101 LPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFAN--EDSHR 1158
T + S S S + + + + E +R
Sbjct: 562 ----------------------TRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYR 599
Query: 1159 KCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSG 1218
+ R+R + TP R+ ++R S ++S + R+ + S+HR
Sbjct: 600 RRGRSRSRERRTPPGRSRSKDRRR---RRRDSRSSEREESQSRNKDKYRNQESKSSHRKE 656
Query: 1219 DDQSGRKRVLHSGSRDREKTK-SLEITGER-KSRIDQLKRGEPSRSTSSDRQDSRSHSSR 1276
+ +S ++ ++S SRD + S E +R +S ++K+ S ++
Sbjct: 657 NSESEKR--MYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKI 714
Query: 1277 RSSPESDRQ---------VHSRSGSFD 1294
RSS E + Q VH ++ FD
Sbjct: 715 RSSVEKENQKSKGQENDHVHEKNKKFD 741
Score = 78.6 bits (192), Expect = 4e-14
Identities = 121/589 (20%), Positives = 220/589 (37%), Gaps = 69/589 (11%)
Query: 911 KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK 970
K KV +K+R ++ SS D S+ + +SD + E+ + K +K+ K +
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSD----SSSDSQSSSDSSDSESATEEKSKKRKKKHR 235
Query: 971 KEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG 1030
K +K +K+K KK KKS ++ AQ R
Sbjct: 236 KNS---------------------RKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRP 274
Query: 1031 PRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTP 1090
PPI L+ K E ++ + E P ++ + T
Sbjct: 275 EEIPPIPENRFLMRKSPPKADEKERKNRERER-----ERECNPPNSQPASYQRRLLVTRS 329
Query: 1091 GSTPSPLSSLLPPPPPVATAT-----ATTVPATLAATTAAAATSFSTSAITISTSATPTN 1145
G P + + + T P A S+ I + N
Sbjct: 330 GRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELN 389
Query: 1146 TTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGR 1205
+++ R R + K+ T H + ++ +RK +K+ SN R
Sbjct: 390 EI------KENQRSPVRVKERKI-TDHRNVSESPNRKNEKEKKVKDHKSNSKERDIR--- 439
Query: 1206 LRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSS 1265
R+ D +++ + + + S S+ +EK+KS E + ++ R SRS
Sbjct: 440 -RNSEKDDKYKNKVKKRAKSK---SRSKSKEKSKSKERDSKHNRNEEKRMR---SRSKGR 492
Query: 1266 DRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQER-DRYEHDRERERERR-DTRQREW 1323
D ++ + + S D++ RS S + +L+ + + ++H + +E++RR +R RE
Sbjct: 493 DHENVKEKEKQSDSKGKDQE---RSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSREC 549
Query: 1324 DRDADKDWPRNRDRDRLRERERERE-RDKRRDLDRERERLI-----SDSVERDRDRDRDR 1377
D K +R R+R R R+R R R + D DR R + + R R R R+R
Sbjct: 550 DITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRER 609
Query: 1378 TFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTE 1437
+ S R + + ES SR+ DK R + S + +E ++SE+
Sbjct: 610 RTPPGRSRSKDRRRRRRDSRSSEREESQSRNK---DKYRNQESKSSHR--KENSESEKRM 664
Query: 1438 SLEAGDDESKLDDAHSLGSGAGEGYEPISDDELD-EILAGDAEKREDQQ 1485
++ D S + + I D E+ + + +ED++
Sbjct: 665 YSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEK 713
Score = 75.5 bits (184), Expect = 4e-13
Identities = 107/490 (21%), Positives = 191/490 (38%), Gaps = 88/490 (17%)
Query: 58 RFVHGPSPR-----GKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPV 112
R + G PR + S + R E P +E + +R V + + ++S
Sbjct: 331 RKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNE 390
Query: 113 RKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQK 172
KE+ R R KE KIT R NV NR + K +K
Sbjct: 391 IKENQRSPVRVKER-KITDHR-------NVSESPNRKNE-----------------KEKK 425
Query: 173 IQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASK 232
+ K + N ++R+ +R R S K K K+ K + SK
Sbjct: 426 V-----KDHKSNSKERD------------IR---------RNSEKDDKYKNKVKKRAKSK 459
Query: 233 KDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEE 292
K+ S ++R+SK N++++K R+ + K + + ++E
Sbjct: 460 SRSKSKEKSK---SKERDSKHNRNEEKRMRS-----------------RSKGRDHENVKE 499
Query: 293 KTRDGKDRGRDFERQREKRDKPRSTSPAGQH-HSPISSRHHSSSSQSGSSIQRHSPSPRR 351
K + +G+D ER R K + S + +H HS + + S+S
Sbjct: 500 KEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYN 559
Query: 352 KRTPSPSYQRTLTPPLR-RSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSH 410
RT S R + +R R+ S S + ++ R R R + R S+S
Sbjct: 560 SRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSK 619
Query: 411 DRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRREL 470
DRR RR D+R E SR + +Y +S S +++ E ++R +RD
Sbjct: 620 DRR-RRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSE----SEKRMYSKSRDHNSS 674
Query: 471 RDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYG 530
+SR+ + R+ +S+ + S+D + + + D + R + KE+ ++S+
Sbjct: 675 NNSREKKADRDQSPFSKIKQSSQD--NELKSSMLKNKEDEKIRSSVEKEN---QKSKGQE 729
Query: 531 RNHLREESSR 540
+H+ E++ +
Sbjct: 730 NDHVHEKNKK 739
Score = 47.8 bits (112), Expect = 8e-05
Identities = 77/362 (21%), Positives = 141/362 (38%), Gaps = 54/362 (14%)
Query: 1166 EKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225
E + V E+ + K SSS S+ S+ S +S S S+DS + + RK
Sbjct: 176 ELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSS----SDSSDSESATEEKSKKRK 231
Query: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQ 1285
+ SR +K E+K R K+ + S S+ S+ ++ + PE
Sbjct: 232 KKHRKNSRKHKK--------EKKKR----KKSKKSASSESEAENLEAQPQSTVRPEEIPP 279
Query: 1286 V-HSRSGSFDSRDRLQERDRYEHDRERERE------------RRDTRQREWDRDADKDWP 1332
+ +R S + E++R +RERERE RR R + +
Sbjct: 280 IPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPR 339
Query: 1333 RNRDRDRLRERERERERDK----RRDLDR-ERERLISDSVERDRDRDRDRTFESSQIESV 1387
R R R R R+R R + R+++ R +R R+ S D+ + +Q V
Sbjct: 340 RYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPV 399
Query: 1388 KRCEAKL------------EGEHE---RDLESTSRD-SLALDKERMDKDLGSV----QGF 1427
+ E K+ + E E +D +S S++ + + E+ DK V +
Sbjct: 400 RVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSK 459
Query: 1428 EETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDE 1487
+ E+++S E ++ ++ G +E + + E G ++R +++
Sbjct: 460 SRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEK 519
Query: 1488 EK 1489
K
Sbjct: 520 SK 521
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 144 bits (362), Expect = 9e-34
Identities = 69/207 (33%), Positives = 137/207 (66%), Gaps = 16/207 (7%)
Query: 599 RSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDE 658
R S +++R ER+ R + R+ +R G+++++ R++++R R + N E E E
Sbjct: 55 RESERKKERR-EREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKE 113
Query: 659 RREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERE 718
+R+++ + ER R +ER+R+ ER+RE ++RER+KE ER +ERER+
Sbjct: 114 KRKKKE-------KKERGRTSKEGKERERKEERKREERKERERKKE-----EREKERERK 161
Query: 719 REKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR 778
K+R+R++ +++ +R +E+ER K+RER R+ER++ERER+ RER++ER+++ R
Sbjct: 162 ERKKRERKQVGEKEEER---KEKERKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 779 ERDKERERQRDWEDKDKGRDDRREKRE 805
+++++++RQ +W +K++G+ +R+E+++
Sbjct: 219 KKERQKDRQTNWREKERGKRERKERKK 245
Score = 132 bits (333), Expect = 2e-30
Identities = 73/216 (33%), Positives = 127/216 (58%), Gaps = 14/216 (6%)
Query: 642 SSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDR-- 699
S P G E+ ER E R + +R ER +ER +R RERE+ER+RER +
Sbjct: 26 SKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKE 85
Query: 700 ---EREKERELERERARERERE-------REKERDRERDRDRDHDRERERERERDREKER 749
ER+KE ++R RE+E + R+K+ +ER R +ERER+ ER RE+ +
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 750 EREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE--EI 807
ERER++ ERE+ERER+ ++RER++ +E +++ + +++ + +++ R +R+++RE E
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKER 205
Query: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE 843
RE + R +ERK +++ + + ++ KR R+
Sbjct: 206 RERKKERKKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 130 bits (327), Expect = 1e-29
Identities = 77/230 (33%), Positives = 130/230 (56%), Gaps = 26/230 (11%)
Query: 677 RERDRERERDRERERERERERDREREKERELERERARERERER-EKERDRERDRDRDHDR 735
RER+RE E +E ++ERE ER +ER + + +RER +ER+RER +KE+ ER ++ +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 736 ERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDK 795
+R RE+E +E+E+ +++ ++ER R + +ERER+ ER RE KERER+++ +K++
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKER 158
Query: 796 GRDDRREK-REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSG 854
R +R+++ R+++ E R + ++ KKR RN + K RRE +
Sbjct: 159 ERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK----- 213
Query: 855 DDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDR-KPERKESSR 903
K E+ + Q +DRQ W+E++R K ERKE +
Sbjct: 214 --KKEERKKERQ----------------KDRQTNWREKERGKRERKERKK 245
Score = 115 bits (289), Expect = 3e-25
Identities = 68/212 (32%), Positives = 116/212 (54%), Gaps = 17/212 (8%)
Query: 699 REREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERER 758
RERE+E E +E +ERE ER+KER RERE+ R+R+REKER+RER ++E+
Sbjct: 39 REREREIETRKEGKKERESERKKER-----------REREK-RKREREKERKRERGKKEK 86
Query: 759 ERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHD 818
+ ER++E ++R RE+ + +E+E+++ E K++GR + K E +E+R +
Sbjct: 87 KGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERK----RE 142
Query: 819 ERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSP 878
ERK ++R + E + +++RE + +K K R + R + +
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER 202
Query: 879 SHLTEDRQGRWKEEDRKPER-KESSRRYEEQE 909
E ++ R K+E+RK ER K+ + E+E
Sbjct: 203 KERRERKKERKKKEERKKERQKDRQTNWREKE 234
Score = 108 bits (269), Expect = 5e-23
Identities = 74/248 (29%), Positives = 130/248 (52%), Gaps = 42/248 (16%)
Query: 719 REKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERER-ERERERERA 777
RE+ER+ E ++ +RE ER++ER RERE+R+RERE+ER+RER ++E++ ER
Sbjct: 39 REREREIETRKEGKKERESERKKER-------REREKRKREREKERKRERGKKEKKGERK 91
Query: 778 RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQS 837
+E + ++R+R+ E+K+ ++R+K+E+ R ++G + + ++R R E R+
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151
Query: 838 PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE 897
+R +E + K K R QV +E R ++R+ R K E + E
Sbjct: 152 EEREKER----------ERKERKKRERKQVGEKEEERK------EKERKERKKRERNRKE 195
Query: 898 RKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENK 957
RK+ R E +E K K+R++ E + R + DR+T+ R + K
Sbjct: 196 RKKERERKERRERK-------KERKKKEERKKERQK-----------DRQTNWREKERGK 237
Query: 958 KKAKIQKK 965
++ K +KK
Sbjct: 238 RERKERKK 245
Score = 96.7 bits (239), Expect = 2e-19
Identities = 65/217 (29%), Positives = 118/217 (54%), Gaps = 14/217 (6%)
Query: 531 RNHLREESSRTEIRNESRNESRSEI---RNDRMGRSRGRVPELP-EKGSRGSRGSQIDSH 586
++ +RE E R E + E SE R +R R R R E E+G + +G +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 587 SSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIR 646
E + E+++ +++ +++ R S + ER+R++ R+R++R +
Sbjct: 95 RERKKRRREKENKEG-EEKEKRKKKEKKERGRTS---KEGKERERKEERKREERKERERK 150
Query: 647 HQGRNDELERDER--REERRVDRVDDRRDERARE--RDRERERDRERERERERERDRERE 702
+ R E ER ER RE ++V ++ R E+ R+ + RER R +ER++ERER+ RER+
Sbjct: 151 KEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNR-KERKKERERKERRERK 209
Query: 703 KERELERERAREREREREKERDRERDRDRDHDRERER 739
KER+ + ER +ER+++R+ RE++R + +ER++
Sbjct: 210 KERKKKEERKKERQKDRQTNW-REKERGKRERKERKK 245
Score = 88.6 bits (218), Expect = 4e-17
Identities = 64/250 (25%), Positives = 113/250 (45%), Gaps = 42/250 (16%)
Query: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGR-NHLREESS 539
E+R+ R+ + ++ + R + + R+RE R R+++ E + + +EE
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 540 RTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599
R + R E N+ E + + + E E+G G
Sbjct: 97 RKKRRREKENKEGEE-------KEKRKKKEKKERGRTSKEGK------------------ 131
Query: 600 SSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER 659
ER+R ER R+ ER + +R RER +R + G +E +++
Sbjct: 132 ----ERERKEER-----KREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182
Query: 660 REERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERER 719
R+ER+ +R+ +ER +ERER RER++ER++ ER+KER+ +R+ RE+ER
Sbjct: 183 RKERK------KRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ-TNWREKER 235
Query: 720 EKERDRERDR 729
K +ER +
Sbjct: 236 GKRERKERKK 245
Score = 85.5 bits (210), Expect = 4e-16
Identities = 74/284 (26%), Positives = 131/284 (46%), Gaps = 80/284 (28%)
Query: 747 KEREREREER-ERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE 805
+ERERE E R E ++ERE ER++ER +R RER+KER+R+R G+ +++ +R+
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRER-------GKKEKKGERK 91
Query: 806 EIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLS 865
+ +ER+ KKR R + + + KR++ K +K R
Sbjct: 92 K-----------EERERKKRRREKENKEGEEKEKRKK--------------KEKKER--- 123
Query: 866 QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE 925
GR +E ++ ERKE +R E +E + K +K+RE+ E
Sbjct: 124 ---------------------GRTSKEGKERERKEERKREERKERERKKEEREKERERKE 162
Query: 926 ILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985
+ R + + + E+R+ +R + +KK + +K KK++E ER
Sbjct: 163 RKKRERKQVGE-----KEEERKEKER---KERKKRERNRKERKKERERKERRER------ 208
Query: 986 SEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKR 1029
KK +KKK KK ++ ++ ++E ++ +K+R
Sbjct: 209 ---------KKERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Score = 68.9 bits (167), Expect = 4e-11
Identities = 56/260 (21%), Positives = 116/260 (44%), Gaps = 37/260 (14%)
Query: 378 SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYE 437
S S + + P +S +RE+ R R +R ER+++ R + R+++ +ER+ E
Sbjct: 21 SCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE 80
Query: 438 QDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRD 497
+ + + R +E R+ + RR ++ ++ E ++ R +E ++ R +KE ++ R+
Sbjct: 81 RGKKEKKGER-KKEERERKKRRREKENKEGEE----KEKRKKKEKKERGRTSKEGKE-RE 134
Query: 498 SRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRN 557
+ R + ++RE + R+++ +E R++ R ++ E E + + R
Sbjct: 135 RKEERKREERKERERKKEEREKERERKE---------RKKRERKQV-GEKEEERKEKERK 184
Query: 558 DRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQA 617
+R R R R E+ + E R ER + ER +++
Sbjct: 185 ERKKRERNRKERKKERERK--------------------ERRERKKERKKKEER-KKERQ 223
Query: 618 RDSSFERRHGERDRRDNRER 637
+D R ER +R+ +ER
Sbjct: 224 KDRQTNWREKERGKRERKER 243
Score = 68.6 bits (166), Expect = 5e-11
Identities = 56/237 (23%), Positives = 106/237 (44%), Gaps = 23/237 (9%)
Query: 1163 TRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQS 1222
T ++ V H++ KP Q S R T + + ++
Sbjct: 15 TELQMVSCSHIS-------KPCTQPGWQSEIREREREIETRKEGKKERESERKKERRERE 67
Query: 1223 GRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPES 1282
RKR R RE+ K + +K ++ KR + + ++ R ++ +
Sbjct: 68 KRKREREK-ERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT 126
Query: 1283 DRQVHSRSGSFD-SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPR-------- 1333
++ R + R+ +ER+R + +RE+ERER++ ++RE + +K+ R
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186
Query: 1334 -NRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
R+R+R +ER++ERER +RR+ +ER++ ER ++R +DR + E KR
Sbjct: 187 KKRERNR-KERKKERERKERRERKKERKK----KEERKKERQKDRQTNWREKERGKR 238
Score = 67.4 bits (163), Expect = 1e-10
Identities = 58/250 (23%), Positives = 101/250 (40%), Gaps = 50/250 (20%)
Query: 459 RDARDTRDRRELRDSRDMRDSREMRDYSRD-TKESRDPRDSRSTRDAHDYRDREGRDTHR 517
R+ ++ ++ R+S ++ RE R+ KE + R + + +RE + R
Sbjct: 43 REIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRR 102
Query: 518 KEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRG 577
+++ E + + ++E RT + R R +R R R +
Sbjct: 103 EKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK----------- 151
Query: 578 SRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRER 637
E R ER +R+ R Q + ER+ ER R RER
Sbjct: 152 -------------------EEREKERERKERKKRE-RKQVGEKEEERKEKERKERKKRER 191
Query: 638 DQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERE-RERE 696
+++ R E ER ERRE R+ ER ++ +R++ER ++R+ RE+E
Sbjct: 192 NRKE--------RKKERERKERRE---------RKKERKKKEERKKERQKDRQTNWREKE 234
Query: 697 RDREREKERE 706
R + KER+
Sbjct: 235 RGKRERKERK 244
Score = 63.2 bits (152), Expect = 2e-09
Identities = 39/187 (20%), Positives = 87/187 (46%), Gaps = 7/187 (3%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
R+REK K ++ R + K+GE + ++ R ++ + R+ +
Sbjct: 64 REREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKER 123
Query: 1293 FDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
+ +ER+R E + ER+ R+ ++ E +++ ++ + R+R ++ E+E ER+ +R
Sbjct: 124 GRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKER 183
Query: 1353 RDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLAL 1412
++ + ER+R R+R E + E K+ E ++D ++ R+
Sbjct: 184 KERKKRERNRKERKKERERKERRERKKERKKKEERKK-------ERQKDRQTNWREKERG 236
Query: 1413 DKERMDK 1419
+ER ++
Sbjct: 237 KRERKER 243
Score = 61.2 bits (147), Expect = 7e-09
Identities = 57/242 (23%), Positives = 108/242 (44%), Gaps = 15/242 (6%)
Query: 327 ISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLR----RSASPYPSHSLSSP 382
ISSR ++ + + +Q S S K P +Q + R R S
Sbjct: 5 ISSR---AAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKK 61
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
+R++ R R +E+ R + + + +R+ E RE R KR REK+++E E E+ +
Sbjct: 62 ERREREKRKREREKERKR-ERGKKEKKGERKKEERE--RKKRRREKENKEGEEKEKRKKK 118
Query: 443 SRDHRDDREPRDG--RDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRS 500
+ R R ++G R+R++ R +R+E ++ R+ +E R +E + +
Sbjct: 119 EKKERG-RTSKEGKERERKEERKREERKERERKKEERE-KERERKERKKRERKQVGEKEE 176
Query: 501 TRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRM 560
R + ++R+ R+ +RKE E R R +E + E + E + + ++ R
Sbjct: 177 ERKEKERKERKKRERNRKE-RKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER 235
Query: 561 GR 562
G+
Sbjct: 236 GK 237
Score = 59.7 bits (143), Expect = 2e-08
Identities = 55/242 (22%), Positives = 102/242 (42%), Gaps = 20/242 (8%)
Query: 1121 ATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQH 1180
A ++ AA +T +S S T + +E R R ++ET E +
Sbjct: 4 AISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEI------REREREIETRK---EGKKE 54
Query: 1181 RKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKS 1240
R+ +K + R R R R +++ +KR +++ E+ K
Sbjct: 55 RESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEE-KE 113
Query: 1241 LEITGERKSRIDQLKRG-EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRL 1299
E+K R K G E R R++ + ++ E +R+ R R+R
Sbjct: 114 KRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERK----KRERK 169
Query: 1300 QERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRER 1359
Q ++ E +E+ER+ R R+R K+ + R+R RER++ER++ + R +R++
Sbjct: 170 QVGEKEEERKEKERKERKKRERN-----RKERKKERERKERRERKKERKKKEERKKERQK 224
Query: 1360 ER 1361
+R
Sbjct: 225 DR 226
Score = 56.6 bits (135), Expect = 2e-07
Identities = 45/209 (21%), Positives = 88/209 (42%), Gaps = 5/209 (2%)
Query: 1232 SRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSG 1291
S RE+ + +E E K + ++ E R R+ R +R + +++ +
Sbjct: 36 SEIREREREIETRKEGKKERESERKKE--RREREKRKREREKERKRERGKKEKKGERKKE 93
Query: 1292 SFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERER---E 1348
+ + R +E++ E + + +R++++ ++R K+ R +R R +ERER E
Sbjct: 94 ERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE 153
Query: 1349 RDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRD 1408
R+K R+ ++R E++ +R E + E ++ K ER R
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213
Query: 1409 SLALDKERMDKDLGSVQGFEETNKSERTE 1437
K+ KD + +E K ER E
Sbjct: 214 KKEERKKERQKDRQTNWREKERGKRERKE 242
Score = 55.8 bits (133), Expect = 3e-07
Identities = 37/186 (19%), Positives = 82/186 (44%), Gaps = 9/186 (4%)
Query: 1176 EDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR 1235
E + + ++KR + R + + ++ G+++ RK+ ++R
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKK---KEKKER 123
Query: 1236 EKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS 1295
+T G+ + R ++ KR E + + + +QV +
Sbjct: 124 GRTSK---EGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKE 180
Query: 1296 RDRLQERDRYEHDRER--ERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRR 1353
++R + + R + +ER ERER++ R+R+ +R ++ + R +DR + RE+ER KR
Sbjct: 181 KERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDR-QTNWREKERGKRE 239
Query: 1354 DLDRER 1359
+R++
Sbjct: 240 RKERKK 245
Score = 53.5 bits (127), Expect = 2e-06
Identities = 45/176 (25%), Positives = 90/176 (51%), Gaps = 16/176 (9%)
Query: 872 ESRSLSPSHLTED-RQGRWKEEDRKPER-----KESSRRYEEQELKEKVSSVDKQREQTE 925
E + +S SH+++ Q W+ E R+ ER KE + E + KE+ ++RE+ +
Sbjct: 16 ELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREK 75
Query: 926 ILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985
+ R + + G + E+RE R ++ K+ + ++K KK+K+ ERG T
Sbjct: 76 ERKRERGKKEKK-GERKKEERERKKRRREKENKEGEEKEKRKKKEKK-----ERGR---T 126
Query: 986 SEDGQVFSPKKGQKKKS-IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKE 1040
S++G+ K+ +K++ E++RKK + + + +E ++ +K+ G + KE
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKE 182
Score = 50.4 bits (119), Expect = 1e-05
Identities = 54/240 (22%), Positives = 103/240 (42%), Gaps = 59/240 (24%)
Query: 802 EKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKH 861
E RE RE ++G ER+S+++ R+ KR+RE + K E+
Sbjct: 37 EIREREREIETRKEGKKERESERKKER------REREKRKREREKER--------KRERG 82
Query: 862 RLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQR 921
+ + R +E R +R+ R +E++ K ++ R+ +E++ + + S K+R
Sbjct: 83 KKEKKGERKKEER---------ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 922 EQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGN 981
E+ E + E+R+ +R +E +K+ ++K KK++ VG
Sbjct: 134 ERKE--------------ERKREERKERERKKEEREKER--ERKERKKRERKQVG----- 172
Query: 982 IETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEE 1041
+K +++K EK+RK+ K E ++ +K+R R KEE
Sbjct: 173 -------------EKEEERK--EKERKERKKRERNRKERKKERERKERRERKKERKKKEE 217
Score = 49.7 bits (117), Expect = 2e-05
Identities = 36/141 (25%), Positives = 69/141 (48%), Gaps = 4/141 (2%)
Query: 1309 RERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVE 1368
RERERE ++ + +R++++ R R+R++ R+RERE+ER + R ++ + E
Sbjct: 39 REREREIETRKEGKKERESERKKER-REREK-RKREREKERKRERGKKEKKGERKKEERE 96
Query: 1369 RDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFE 1428
R + R E + E K+ E K G ++ + R +ER +++ + +
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREK 156
Query: 1429 ETNKSER--TESLEAGDDESK 1447
E + ER E + G+ E +
Sbjct: 157 ERERKERKKRERKQVGEKEEE 177
Score = 48.5 bits (114), Expect = 5e-05
Identities = 46/248 (18%), Positives = 91/248 (36%), Gaps = 40/248 (16%)
Query: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
+ E E+ EI +KE E R+S + +R+ K +K+RK
Sbjct: 35 QSEIREREREIETRKEGKKE------------RESERKKERREREKRKREREKERKRERG 82
Query: 241 SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR 300
+++ + + K++ + E+ +K K K K K +++GK+R
Sbjct: 83 KKEKKGERKKEERERKKRRREK---------ENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 301 GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ 360
R ER+RE+R + + R Q G + R++R
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKR---- 189
Query: 361 RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT 420
+ ++++ R +E+ + + + + DR+ RE
Sbjct: 190 ---------------ERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKE 234
Query: 421 RGKRDREK 428
RGKR+R++
Sbjct: 235 RGKRERKE 242
Score = 47.8 bits (112), Expect = 8e-05
Identities = 49/203 (24%), Positives = 88/203 (43%), Gaps = 25/203 (12%)
Query: 64 SPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHRE 123
S R K +R ER RER K +++ E +K E KE+ G +E
Sbjct: 57 SERKKERREREKRKREREKERKRERGKKEKKG---ERKKEERERKKRRREKENKEGEEKE 113
Query: 124 KEDIKITKER---TPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL 180
K K KER + E +E + E R++ + + E ++++ ++E K
Sbjct: 114 KRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE-------EREKERERKERKKR 166
Query: 181 EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV 240
E++ + ++EE +KE R K + RK + K + K K++RK
Sbjct: 167 ERKQVGEKEEERKEKE---RKERKKRERNRKERKKERERKERRERKKERKKKEERKK--- 220
Query: 241 SSPLLDQQRNSKTN-QSKKKGPR 262
++Q++ +TN + K++G R
Sbjct: 221 -----ERQKDRQTNWREKERGKR 238
Score = 47.0 bits (110), Expect = 1e-04
Identities = 52/242 (21%), Positives = 98/242 (40%), Gaps = 40/242 (16%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
R R G + K++ + E +KR E+ R + + R+KE+ + K R
Sbjct: 43 REIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRR- 101
Query: 135 PESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIK 194
E+EN E E E K++K +R E + E++EE K
Sbjct: 102 --REKENKEGE-----------------EKEKRKKKEKKERGRTSKEGKERERKEE--RK 140
Query: 195 KEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTN 254
+E E + K +R+ + K++RK +++R K
Sbjct: 141 REERKE-------------RERKKEEREKERERKERKKRERKQVGEK----EEERKEKER 183
Query: 255 QSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFER-QREKRDK 313
+ +KK R E ++ KE+ K ++R +E+ +D + R+ ER +RE++++
Sbjct: 184 KERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKER 243
Query: 314 PR 315
+
Sbjct: 244 KK 245
Score = 43.1 bits (100), Expect = 0.002
Identities = 28/105 (26%), Positives = 54/105 (51%), Gaps = 6/105 (5%)
Query: 1337 RDRLRERERE----RERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEA 1392
+ +RERERE +E K R+ +R++ER + +R+R+++R R + + ++ E
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 1393 KLEGEHERDLESTSRDSLALDKERMDKDLG--SVQGFEETNKSER 1435
+ + R+ E+ + K++ K+ G S +G E K ER
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEER 139
Score = 41.6 bits (96), Expect = 0.006
Identities = 43/174 (24%), Positives = 74/174 (42%), Gaps = 16/174 (9%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEES--SSPVRKESSRGRHRE 123
RGK R+ ER R +NK + + +K+ +E +S KE R R+
Sbjct: 81 RGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERK 140
Query: 124 KEDIKITKERTPESEEENVEWETN-RDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQ 182
+E+ K + + E E+E E R+ G+ + + E K+++ R+ K E+
Sbjct: 141 REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKER 200
Query: 183 ENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
E E+R KKE R K RK + R+++ + K++RK
Sbjct: 201 ERKERR---ERKKE------RKKKEE----RKKERQKDRQTNWREKERGKRERK 241
Score = 40.0 bits (92), Expect = 0.018
Identities = 37/162 (22%), Positives = 71/162 (43%), Gaps = 23/162 (14%)
Query: 923 QTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNI 982
Q+EI E R + E R+ + + +KK + +++ K+++E + ERG
Sbjct: 35 QSEIRERER----------EIETRKEGKKERESERKKERREREKRKREREKERKRERGKK 84
Query: 983 ETTSEDGQVFSPKKGQKKKSIE--KKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKE 1040
E KKG++KK KKR++ K + + ++E ++ +KK RT +
Sbjct: 85 E-----------KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKER 133
Query: 1041 ELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082
E E + + +K+E + + +R +V E E
Sbjct: 134 ERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKE 175
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 141 bits (355), Expect = 6e-33
Identities = 119/591 (20%), Positives = 268/591 (45%), Gaps = 36/591 (6%)
Query: 516 HRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRN------DRMGRSRGRVPE 569
H+K D Y EE R+ L E R I NE + +E++ + V E
Sbjct: 192 HKKADRYIEELTKE-RDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 570 LPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGER 629
L K R + +N+ + W E+++ + R R E
Sbjct: 251 LKRKLERAK--FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-RLREQEG 307
Query: 630 DRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDR----------RDERARER 679
R+ E+ R +R Q + + E RE++ + +++ ++E+ RE+
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 680 DRERERDRERERERERERDREREKERELERERAREREREREKE-RDRERDRDRDHDRERE 738
+ + R ER E+E++ + +K R+ E + ER REKE R RE+++ + +
Sbjct: 368 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMR 427
Query: 739 RERERDREKEREREREERERERERERERERERERERERARERDKERERQRD--WEDKDKG 796
E++ ++++ R++EE+ +E ER RERE++ E E RE++++ ++Q + WE ++K
Sbjct: 428 EEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKE 487
Query: 797 RDDRR--EKREEIREDRNPRDGHD---ERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAY 851
+R E++E++ E ++ + E++ K R + E ++ ++ + + +
Sbjct: 488 WQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW 547
Query: 852 NSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELK 911
+ ++ + + E ++ T D++ + +EE+R ER E R EE+ ++
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMRER-EKKMREEEEMMR 606
Query: 912 EKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKK 971
E+ + +Q E+ + E ++ + + + E ++ ++ +K + Q+ P +K+K
Sbjct: 607 EQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 972 EDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGP 1031
+ + + ++ +++ +K +KK +++ KK+ + +EE+ ++ +KK
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREEESMREREKKMRE 724
Query: 1032 RTPPITTKEELVE-----MCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTE 1077
+ +EE ++ M + + E +K + W + +P++ E
Sbjct: 725 EEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKE 775
Score = 136 bits (342), Expect = 2e-31
Identities = 151/755 (20%), Positives = 325/755 (43%), Gaps = 66/755 (8%)
Query: 283 KYKVKDR-IEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSS 341
++K DR IEE T++ + R ++ + + Q P++ S +
Sbjct: 191 RHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKE 250
Query: 342 IQRHSPSPRRKRTPSPSYQ-RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGR 400
++R R + P Q TL + R ++++ R +RE+
Sbjct: 251 LKRKL---ERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEG 307
Query: 401 HDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRD 460
E+ + + RE + R++EK+ RE++E + + + ++E +
Sbjct: 308 KMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQE----EQMQEQEEKMWEQEEK 363
Query: 461 ARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKED 520
R+ ++ ++ R ++MR+ + + RD D R RE + R+++
Sbjct: 364 MREQEEKMWRQEERLWEQEKQMRE------QEQKMRDQEERMWEQDERLREKEERMREQE 417
Query: 521 TYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRG 580
E+ +REE E ++R++ +R+ ++ E E+ + +
Sbjct: 418 KMWEQVEK-----MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMRE--EEETMREQE 470
Query: 581 SQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQR 640
++ N WE ++ R PE+ E+ + ++ E+
Sbjct: 471 EKMQKQEENM-----WEQEEKEWQQQRLPEQK----------EKLWEQEKMQEQEEKIWE 515
Query: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRE 700
IR Q E+ R+E+ ++ D ++ + RD+E++ + ER ++ +++E
Sbjct: 516 QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQE 575
Query: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
++ + E+ R ER REREK+ E + RE+E + + EK +E+E + E+E
Sbjct: 576 KKTWDQEEKMREEERMREREKKMREEEEM----MREQEEKMQEQEEKMQEQEEKMWEQEE 631
Query: 761 ERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDER 820
+ + + E+ E+E + + +K E+QR E K+K + + + +E +++ + E+
Sbjct: 632 KMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEK 691
Query: 821 KSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSH 880
KK E ++ K R E S ++ +K R +++R QE +
Sbjct: 692 MEKKTQEQEKKTWDQE--KMREEESM--------REREKKMREEEEMMREQEEKMQEQEE 741
Query: 881 -LTEDRQGRWKEEDRKPERKESSRRYEEQEL---KEKVSSVDKQREQTEILE-SSRMRAQ 935
+ E + W++E++ E++E + +E+Q L KEK+ +K +EQ +I E +MR Q
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEE--KMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Query: 936 DIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPK 995
+ Q E + ++K Q++ + ++E G E + ++ ++
Sbjct: 800 EEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE---KMWGQEEKMEEKM 856
Query: 996 KGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRG 1030
+GQ++K + ++ +K +G +E+ +Q +K RG
Sbjct: 857 QGQEEK-MREQEEKMRG----QEEKMREQEEKMRG 886
Score = 104 bits (259), Expect = 8e-22
Identities = 95/558 (17%), Positives = 239/558 (42%), Gaps = 57/558 (10%)
Query: 390 RHRSPMREKGRHDHERTSQSHDRRHERRE-DTRGKRDREKDSREEREYEQDQSSSRDHRD 448
R + +RE+ E+ + ++ + RE + + R E+ +E++ + + RD +
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 449 DREPRDGRDRRDARDTRDRRELRDSRD-MRDSREMRDYSRDTKESRDP---------RDS 498
+D R R R++ ++ + + MR+ ++M++ + T++ + R+
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREK 457
Query: 499 RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE------ESSRTEIRNESRNESR 552
+ + R++E + ++E+ + +E + + + L E E + + + E E
Sbjct: 458 KMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQE 517
Query: 553 SEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERD 612
+IR+ + + EK W+ ++ + E+
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Query: 613 NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR---EERRVDRVD 669
DQ E R ER+++ E + + Q + ++++ E + +E ++ +
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 670 DR----------RDERARERDR---------ERERDRERERERERER---DREREKEREL 707
++ ++E+ E+ R E E+ +E+E+ +E+E ++E+ +++
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 708 ERERA-----REREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
E+E+ + RE E +ER+++ + + RE+E + + EK +E+E E E+E +
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM 757
Query: 763 ERERERERERER-----ERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGH 817
+ E+ E++R E+ E +K +E+++ WE ++K RD + E++R G
Sbjct: 758 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRD----QEEKMRGQEEKMRGQ 813
Query: 818 DERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS 877
+E+ + + G + + + + + + EK + + +R QE +
Sbjct: 814 EEKMRGQEEKMWGQ-EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRG 872
Query: 878 PSHLTEDRQGRWKEEDRK 895
+++ + + ++ K
Sbjct: 873 QEEKMREQEEKMRGQEEK 890
Score = 65.9 bits (159), Expect = 3e-10
Identities = 99/686 (14%), Positives = 273/686 (39%), Gaps = 102/686 (14%)
Query: 85 LRERM-KNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
LRE+ K + Q+ Q++ E +R++ RE+++++ +E+ E EE+
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKE--LREQKELREQEEQMQEQEEK--M 357
Query: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
WE + + + L + K+ + Q + M+ ++E M +++E + +KE
Sbjct: 358 WEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE------- 410
Query: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRT 263
+R+ K ++ +++ R K Q ++K R
Sbjct: 411 ------ERMREQEKMWEQ-----------------------VEKMREEKKMQEQEKKTRD 441
Query: 264 PSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQH 323
+K +E+ ++++R E+K R+ ++ R+ E + +K+++
Sbjct: 442 QE------------EKMQEEERIRER-EKKMREEEETMREQEEKMQKQEE---------- 478
Query: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQ 383
+ + Q+ P + K Q + + +
Sbjct: 479 --------NMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
+K + MRE+ E+ + D + ++ D + +++ +E++ ++Q++
Sbjct: 531 KKM---WRQEKMREQEDQMWEQEEKMRD-QEQKMWDQEERMEKKTQEQEKKTWDQEE--- 583
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRD 503
+ R + R +++R+ +M RE + ++ +E ++ +
Sbjct: 584 ------------KMREEERMREREKKMREEEEM--MREQEEKMQEQEEKMQEQEEKMWEQ 629
Query: 504 AHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRS 563
+++E + ++E + +E + + + L E+ + + + + + + + +++
Sbjct: 630 EEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQ 689
Query: 564 RGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFE 623
E EK ++ D + E + E++ + Q ++ +
Sbjct: 690 -----EKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744
Query: 624 RRHGERDRRDNR--ERDQRPSSPIRHQGRNDEL-ERDERREERRV-DRVDDRRDERARER 679
+ E ++ + E++++ R + ++L E ++ +E+ ++ ++ + RD+ + R
Sbjct: 745 EQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR 804
Query: 680 DRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERER 739
+E + + E+ R +E ++E+ +E + E+ ++ + + E+ R
Sbjct: 805 GQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMR 864
Query: 740 ERERDREKEREREREERERERERERE 765
E+E + E+ RE+ E+ R +E +
Sbjct: 865 EQEEKMRGQEEKMREQEEKMRGQEEK 890
Score = 63.5 bits (153), Expect = 1e-09
Identities = 77/408 (18%), Positives = 176/408 (43%), Gaps = 40/408 (9%)
Query: 682 ERERDRERERERERERDR---EREKERE---LERERAREREREREKERDRERDRDRDHDR 735
E +R R ++ DR E KER+ LE R E +K+ +++ +
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 736 ERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRD--WEDK 793
E+ + +E +R+ ER + + + + E R+ E RE++K+ +Q + W +
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE 299
Query: 794 DKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNS 853
++ RE+ ++RE + +KR R E R+ K RE +
Sbjct: 300 ER----LREQEGKMREQEEKM-----WRQEKRLR-EQEKELREQEKELREQKELREQEEQ 349
Query: 854 GDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEK 913
++ EK + +R QE + +++ + +E+++K +E +++ L+EK
Sbjct: 350 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 409
Query: 914 VSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKED 973
+ +Q + E +E +MR + + + + R+ ++ +E + + + +K +++E+
Sbjct: 410 EERMREQEKMWEQVE--KMREEKKMQEQEKKTRDQEEKMQEEERIREREKK---MREEEE 464
Query: 974 DVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRT 1033
+ + ++ E+ K+ Q+++ E+K K + ++E Q+ ++K +
Sbjct: 465 TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEK-------LWEQEKMQEQEEKIWEQE 517
Query: 1034 PPITTKEEL----------VEMCNGKNGILEDSQKKEDTAFSDWSDED 1071
I +EE+ +M ++ + E +K D W E+
Sbjct: 518 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565
Score = 48.1 bits (113), Expect = 6e-05
Identities = 49/316 (15%), Positives = 134/316 (42%), Gaps = 34/316 (10%)
Query: 1205 RLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTS 1264
R+ + + ++ D + + R+++ + E+ E++ ++ + + +
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEK 625
Query: 1265 SDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDR--YEHDRERERER-RDTRQR 1321
Q+ + E + ++ + + RL E+ +EH++ +E+E+ ++ ++
Sbjct: 626 MWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Query: 1322 EWDRD-----ADKDWPRNRDRDRLRERERERERDKR----RDLDRERERLISDSVERDRD 1372
W+++ + + D++++RE E RER+K+ ++ RE+E + + E+ ++
Sbjct: 686 IWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQE 745
Query: 1373 RD-------------RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDK 1419
++ ++ +E ++ K + E E++ + + +E+M
Sbjct: 746 QEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRG 805
Query: 1420 DLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAE 1479
++G EE K E G +E + + + +++++E + G E
Sbjct: 806 QEEKMRGQEE--KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWG--QEEKMEEKMQGQEE 861
Query: 1480 KREDQQD-----EEKM 1490
K +Q++ EEKM
Sbjct: 862 KMREQEEKMRGQEEKM 877
Score = 46.6 bits (109), Expect = 2e-04
Identities = 55/268 (20%), Positives = 128/268 (47%), Gaps = 28/268 (10%)
Query: 1235 REKTKSLEITGERKSRIDQLKRGEPSRSTSSD----RQDSRSHSSRRSSPESDRQVHSRS 1290
RE+ K + E+ R ++ R + + + RQ+ R + E ++++ +
Sbjct: 282 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQK 341
Query: 1291 GSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERD 1350
+ +++QE++ E E+E + R+ ++ W R ++ W + + ++RE+E ++ RD
Sbjct: 342 ELREQEEQMQEQE--EKMWEQEEKMREQEEKMW-RQEERLWEQEK---QMREQE-QKMRD 394
Query: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSL 1410
+ + + ERL + +R R++++ +E Q+E ++ E K++ E++ ++ ++
Sbjct: 395 QEERMWEQDERL---REKEERMREQEKMWE--QVEKMRE-EKKMQ---EQEKKTRDQEEK 445
Query: 1411 ALDKERMDKDLGSVQGFEET--NKSERTESLEAG--DDESKLDDAHSLGSGAGEGYEPIS 1466
++ER+ + ++ EET + E+ + E + E K L + +E
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505
Query: 1467 DDELDEILAGDAEKREDQQD----EEKM 1490
E +E + EK DQ++ E+KM
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
Score = 45.4 bits (106), Expect = 4e-04
Identities = 50/266 (18%), Positives = 112/266 (42%), Gaps = 43/266 (16%)
Query: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSR--RSSPES 1282
+R+ + RE+ + + ER D+ R + R ++ + R + E
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQ 435
Query: 1283 DRQVHSRSGSFDSRDRLQERD---RYEHDRERERERRDTRQRE--WDRDADKDWPRNR-- 1335
+++ + +R++ER+ R E + RE+E + +Q E W+++ +K+W + R
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQE-EKEWQQQRLP 494
Query: 1336 -DRDRLRERERERERDK-----------------------RRDLDRERERLISDSVERDR 1371
+++L E+E+ +E+++ R++ RE+E + + E+ R
Sbjct: 495 EQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Query: 1372 DR-----DRDRTFESSQIESVKRC----EAKLEGEHERDLESTSRDSLALDKERMDKDLG 1422
D+ D++ E E K+ E E E R+ E R+ + +E+ +K
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE 614
Query: 1423 SVQGFEETNKSERTESLEAGDDESKL 1448
+ +E + + + + E K+
Sbjct: 615 QEEKMQEQEEKMWEQEEKMQEQEEKM 640
Score = 45.1 bits (105), Expect = 5e-04
Identities = 38/225 (16%), Positives = 106/225 (47%), Gaps = 18/225 (8%)
Query: 1266 DRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDR 1325
D+++ + E R+ + + + R QE+ ++ + E++ ++ ++ WD+
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Query: 1326 DADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIE 1385
+ + R+ +R+RERE++ ++ ++ RE+E + + E+ ++++ ++ +E Q E
Sbjct: 582 EE-----KMREEERMREREKKMREEE--EMMREQEEKMQEQEEKMQEQE-EKMWE--QEE 631
Query: 1386 SVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDE 1445
++ E K+ + E+ E ++ +++R+ + + E+ + E+ + + E
Sbjct: 632 KMQEQEEKMWEQEEKMWE---QEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ-----EQE 683
Query: 1446 SKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKM 1490
K+ + + E + D E E+ + ++EE+M
Sbjct: 684 EKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Score = 43.9 bits (102), Expect = 0.001
Identities = 50/242 (20%), Positives = 111/242 (45%), Gaps = 23/242 (9%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R E+ D ERM+ K T+ Q++ T + +R+E R R REK+ ++ +E
Sbjct: 554 RDQEQKMWDQEERMEKK-----TQEQEKKTWDQEEKMREE-ERMREREKK-MREEEEMMR 606
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
E EE+ E E + + ++ + ++ + Q E M ++E M ++EE + ++
Sbjct: 607 EQEEKMQEQEEKMQEQE---------EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQ 657
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQ 255
+ PE + KL +++ K +++ K K ++KT DQ++ +
Sbjct: 658 QRLPE-QKEKLWEHEKMQEQEKMQEQEE--KIWEQEKMEKKTQEQEKKTWDQEKMREEES 714
Query: 256 SKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKD----RIEEKTRDGKDRGRDFERQREKR 311
+++ + + E ++ +EK + ++ EEK + +++ + +R E++
Sbjct: 715 MREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQK 774
Query: 312 DK 313
+K
Sbjct: 775 EK 776
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 138 bits (348), Expect = 4e-32
Identities = 63/181 (34%), Positives = 126/181 (69%), Gaps = 2/181 (1%)
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVD 669
E + + + R+ +R E++R+ R + ++ R +G+ E +R ER ++R+ R
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 670 DRRDERARERDRERERDRERERERERER-DREREKERELERERAREREREREKERDRERD 728
+RR + ++ RER++ RER++++ER +RERE ++ ER+R + R+++R KER RE++
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQR 788
R + +R+R++ ++ +REK+RER R+ER++ERER+ RER++ER++ER ++++++++R+
Sbjct: 153 RGK-RERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211
Query: 789 D 789
D
Sbjct: 212 D 212
Score = 135 bits (341), Expect = 2e-31
Identities = 68/193 (35%), Positives = 131/193 (67%), Gaps = 6/193 (3%)
Query: 662 ERRVDRVDDRRDERARERDRERERDRER-ERERERERDREREKERELERERARERERERE 720
+R +R +RR+ R+R+RE+ER RER ++E+++ + RER KERE +R +ERE++R+
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR---KEREKQRK 87
Query: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
+ R++ER + + ++RER++ RE+++++ER+ERERE ++ RER+R++ R+++R +ER
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKER 147
Query: 781 DKERER-QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK 839
+E+ER +R+ + K + +++R +KRE R++R ER+ +K+ R + ++ K
Sbjct: 148 KREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKK 207
Query: 840 -RRREHSPDSDAY 851
R+ + DS +
Sbjct: 208 DRKTDRQTDSQVF 220
Score = 132 bits (332), Expect = 3e-30
Identities = 70/194 (36%), Positives = 132/194 (68%), Gaps = 14/194 (7%)
Query: 624 RRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRER 683
+R ER +++ RER++R E E++ +RE + ++ ++ ER +ER+R+R
Sbjct: 31 QRESER-KKERREREKRKR----------EREKERKRERGKKEKKKRKKRERGKERERKR 79
Query: 684 -ERDRERERERERERDREREKERELERERAREREREREKER-DRERDRDRDHDRERERER 741
ER+++R+ RE+ER + ++++++ ER++ RER+++KER +RER+ + +R+R++ R
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 742 ERDREKEREREREERERERERERERERERERERERAR-ERDKERERQRDWEDKDKGRDDR 800
++ R KER+RE+E +RER+R++ ++ ERE++RER R ER KERER+ E K + + +R
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER 199
Query: 801 REKREEIREDRNPR 814
R+K+E ++ + R
Sbjct: 200 RKKKERKKDRKTDR 213
Score = 129 bits (325), Expect = 2e-29
Identities = 69/184 (37%), Positives = 119/184 (64%), Gaps = 4/184 (2%)
Query: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRND-ELERDERREE 662
E +R ER R++ + + R ER +++ ++R +R R + R + E +R ERRE+
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 663 RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722
R R +++ ++R R + ++ +ERERE + RE++R+ R++ R +ER+REKE
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 723 RD-RERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERD 781
R RER R + ERE++RER+R KER++ERE +ER RER++ER++ER +++ER ++R
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNR-KERKKERERKER-RERKKERKKERRKKKERKKDRK 210
Query: 782 KERE 785
+R+
Sbjct: 211 TDRQ 214
Score = 126 bits (317), Expect = 1e-28
Identities = 67/196 (34%), Positives = 133/196 (67%), Gaps = 9/196 (4%)
Query: 640 RPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERER-ERD 698
+P + + + + ER++R+ ER +R +R+ +E+ + ++R+R +ERER+R ER+
Sbjct: 27 KPCTQRESERKKERREREKRKREREKER---KRERGKKEKKKRKKRERGKERERKRKERE 83
Query: 699 REREKERELERERAREREREREKERDRERDRDRDHDR-ERERERERDREKER-EREREER 756
++R++ RE ER + ++ +++RE+++ R+R + +R ERERE ++ RE++R +R +++R
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKR 143
Query: 757 ERERERERER-ERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRD 815
+ER+RE+ER +RER+R++ + ER+K+RER R K++ R +RRE+++E +++R R
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER--RK 201
Query: 816 GHDERKSKKRYRNEGS 831
+ +K +K R S
Sbjct: 202 KKERKKDRKTDRQTDS 217
Score = 122 bits (307), Expect = 2e-27
Identities = 72/196 (36%), Positives = 118/196 (60%), Gaps = 11/196 (5%)
Query: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
+RE +R++ER +R REREKER+ ER + +E+++ +++ER +ER+R R +ERE++R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGK-KEKKKRKKRERGKERERKR---KEREKQR 86
Query: 742 ERDREKE-REREREERERERERERERERERERER-ERARERDKERERQRDWEDKDKGRDD 799
+ REKE R+R++E+++RER++ RER++++ER ER RE + RER+R K K R +
Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 800 RREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNE 859
R+ ++E + +R + E + KKR RN + K RRE + + +
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERK 206
Query: 860 KHRLL-----SQVVRP 870
K R SQV RP
Sbjct: 207 KDRKTDRQTDSQVFRP 222
Score = 115 bits (289), Expect = 3e-25
Identities = 77/254 (30%), Positives = 137/254 (53%), Gaps = 24/254 (9%)
Query: 700 EREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERE 759
+RE ER+ ER +R+REREKER RER + +E+++ ++R+R KERER+R+ERE++
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGK-----KEKKKRKKRERGKERERKRKEREKQ 85
Query: 760 RERERERERERERERERARERDK--ERERQRDWEDKDKGRDDRREKREEIREDRNPRDGH 817
R+ RE+ER + ++ ++ RER + RER++ E K++ R++ +++RE R+ R +
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKEREREN-KQRRERKRKKRRKKKRR 144
Query: 818 DERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS 877
ERK +K E R+ KR++E N + K E+ R +E R
Sbjct: 145 KERKREK----ERGKRERKRKKRKKEEREKKRERNRKERKKERER--------KERRERK 192
Query: 878 PSHLTEDRQGRWKEEDRKPERKESSRRY----EEQELKEKVSSVDKQREQTEILESSRMR 933
E R+ + +++DRK +R+ S+ + E + V+ V + R L+ ++
Sbjct: 193 KERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRVTVTGVFRYRIFHTGLDHFPIK 252
Query: 934 AQDIIGHHQSEDRE 947
++ H+ D E
Sbjct: 253 TNILLSRHEVNDGE 266
Score = 108 bits (270), Expect = 4e-23
Identities = 63/188 (33%), Positives = 116/188 (61%), Gaps = 5/188 (2%)
Query: 597 ETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELER 656
E R E++R ER +++ + ER +R RE+ ++ + R E ++
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Query: 657 DERREERRVDRVDDR-RDERARERDRERERDRERERERERERDREREKER-ELERERARE 714
ER++ R +R + R ER RE + RER R++ R+++R ++R+REKER + ER+R +
Sbjct: 104 RERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKR 163
Query: 715 REREREKERDRER-DRDRDHDRERERERERDREKEREREREERERERERERERERERERE 773
++ EREK+R+R R +R ++ +R+ RER+++R+KER R+++ER+++R+ +R+ + + R
Sbjct: 164 KKEEREKKRERNRKERKKERERKERRERKKERKKER-RKKKERKKDRKTDRQTDSQVFRP 222
Query: 774 -RERARER 780
RE A R
Sbjct: 223 LRESAFNR 230
Score = 89.7 bits (221), Expect = 2e-17
Identities = 60/200 (30%), Positives = 98/200 (49%), Gaps = 20/200 (10%)
Query: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607
R R + R +R R R R EK + RG + R ER R
Sbjct: 32 RESERKKERREREKRKRER-----EKERKRERGKKEKKKRKKRE-------RGKERERKR 79
Query: 608 YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDR 667
R + R+ +R E+ +R+ ++R +R + + + + R +R+ R
Sbjct: 80 KEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 668 VDDRRDERARERDR-ERERDR------ERERERERERDREREKERELERERARERERERE 720
RR ER RE++R +RER R ERE++RER R +ER+KERE + R R++ER++E
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRERNR-KERKKERERKERRERKKERKKE 198
Query: 721 KERDRERDRDRDHDRERERE 740
+ + +ER +DR DR+ + +
Sbjct: 199 RRKKKERKKDRKTDRQTDSQ 218
Score = 83.6 bits (205), Expect = 1e-15
Identities = 57/193 (29%), Positives = 94/193 (48%), Gaps = 8/193 (4%)
Query: 535 REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHD 594
+ ES R + R E E R R R RG+ EK R R +
Sbjct: 31 QRESERKKERRE--REKRKREREKERKRERGK----KEKKKRKKRERGKERERKRKEREK 84
Query: 595 SWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDEL 654
+ R R R E+ R++ + ER+ + + RE QR R + R +
Sbjct: 85 QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK-RKKRRKKKR 143
Query: 655 ERDERREERRVDRVDDRRDERARERDRERERDR-ERERERERERDREREKERELERERAR 713
++ +RE+ R R R+ + ER+++RER+R ER++ERER+ RER+KER+ ER + +
Sbjct: 144 RKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Query: 714 EREREREKERDRE 726
ER+++R+ +R +
Sbjct: 204 ERKKDRKTDRQTD 216
Score = 78.2 bits (191), Expect = 6e-14
Identities = 61/249 (24%), Positives = 112/249 (44%), Gaps = 57/249 (22%)
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKRE 805
++E ER++E RERE+ R+RERE+ER RER K+ +++R ++ K R+ +R++RE
Sbjct: 31 QRESERKKERREREK-------RKREREKERKRERGKKEKKKRKKRERGKERERKRKERE 83
Query: 806 EIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLS 865
+ R++R ++ +K KK+ E R+ K+++E
Sbjct: 84 KQRKERREKERRKRKKEKKK--RERKQRGRRERKKKKE---------------------- 119
Query: 866 QVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE 925
R+ R +E ++ ERK RR +++ + K +K+R + E
Sbjct: 120 -------------------RKERERENKQRRERKRKKRRKKKRRKERK---REKERGKRE 157
Query: 926 ILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETT 985
R + + ++ +R E +++ K +KK +KKKE ++
Sbjct: 158 RKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKER----KKDRKTDR 213
Query: 986 SEDGQVFSP 994
D QVF P
Sbjct: 214 QTDSQVFRP 222
Score = 72.8 bits (177), Expect = 2e-12
Identities = 49/221 (22%), Positives = 96/221 (43%), Gaps = 18/221 (8%)
Query: 495 PRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSE 554
P R + + R+RE R R+++ E + + + E + R E + +
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRK 87
Query: 555 IRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNR 614
R ++ R R + + E+ RG R E + ++R E R
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGRR-----------------ERKKKKERKERERENKQR 130
Query: 615 DQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDE 674
+ + ++ ++R+ +ER +R + + E +R+ R+ER+ +R R E
Sbjct: 131 RERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRE 190
Query: 675 RARERDRERERDRERERERERERDREREKERELERERARER 715
R +ER +ER + +ER+++R+ +R + + R L RE A R
Sbjct: 191 RKKERKKERRKKKERKKDRKTDRQTDSQVFRPL-RESAFNR 230
Score = 68.9 bits (167), Expect = 4e-11
Identities = 52/219 (23%), Positives = 98/219 (44%), Gaps = 16/219 (7%)
Query: 1163 TRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQS 1222
T ++ V H++ KP Q+ S + R R R + G +
Sbjct: 15 TELQMVSCSHIS-------KPCTQRESE----RKKERREREKRKREREKERKRERGKKEK 63
Query: 1223 GRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPES 1282
+++ G K K E + + ++ KR + + ++ R ++ E
Sbjct: 64 KKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Query: 1283 DRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRE 1342
+R+ R + R ++R R E RE+ER +R+ R+R+ + +++ R R+R +E
Sbjct: 124 ERENKQRRERKRKKRRKKKR-RKERKREKERGKRE-RKRKKRKKEEREKKRERNR---KE 178
Query: 1343 RERERERDKRRDLDRERERLISDSVERDRDRDRDRTFES 1381
R++ERER +RR+ +ER++ ER +DR DR +S
Sbjct: 179 RKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDS 217
Score = 68.6 bits (166), Expect = 5e-11
Identities = 46/177 (25%), Positives = 83/177 (46%), Gaps = 8/177 (4%)
Query: 1246 ERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY 1305
ER+ R + + E R +++ + R E +R+ R R + R R
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 1306 EHDRERERERRDTRQR-------EWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRE 1358
+ ++RER++R R+R E +R+ + R R + R ++R +ER+R+K R RE
Sbjct: 99 KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERG-KRE 157
Query: 1359 RERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKE 1415
R+R ER++ R+R+R + E +R E K E + ER + + D++
Sbjct: 158 RKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQ 214
Score = 65.5 bits (158), Expect = 4e-10
Identities = 52/246 (21%), Positives = 96/246 (39%), Gaps = 46/246 (18%)
Query: 406 TSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTR 465
T + +R+ ERRE + KR+REK+ + ER ++ + + R R ++R R R
Sbjct: 30 TQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKER 89
Query: 466 DRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEE 525
+E R + + RE + R ++ + R R R+ R+R+ R RK+ E
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERE-RENKQRRERK-RKKRRKKKRRKER 147
Query: 526 SRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDS 585
R R + E R + + E R + R R +R
Sbjct: 148 KREKERG--KRERKRKKRKKEEREKKRERNRKERK------------------------- 180
Query: 586 HSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPI 645
ER+R R+ + + + +++ ++DR+ +R+ D + P+
Sbjct: 181 -----------------KERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPL 223
Query: 646 RHQGRN 651
R N
Sbjct: 224 RESAFN 229
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/179 (22%), Positives = 80/179 (44%), Gaps = 10/179 (5%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
+R++ R R +E+ R ++ + +R +E R +++REK +E RE E+ +
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
+ +R+ R R+R+ ++ ++R R++++ R+ R + + R R
Sbjct: 99 KEKKKRERKQRGRRERKKKKERKERE--------RENKQRRERKRKKRRKKKRRKERKRE 150
Query: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESR--SEIRNDR 559
R+R+ + ++E E R RE R E + E + E R E + DR
Sbjct: 151 KERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDR 209
Score = 63.5 bits (153), Expect = 1e-09
Identities = 48/200 (24%), Positives = 84/200 (42%), Gaps = 9/200 (4%)
Query: 345 HSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHE 404
H P +R +R +R ++K+ R R RE+ R + E
Sbjct: 24 HISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKERE 83
Query: 405 RTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDT 464
+ +R ERRE R KR +EK RE ++ + + + R +RE + + R R
Sbjct: 84 K------QRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKK 137
Query: 465 RDRRELRDSRDMRDSREMRDYSRD--TKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTY 522
R +++ R R R R+ R KE R+ + R+ ++ R+R+ R RK++
Sbjct: 138 RRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKER-RERKKERK 196
Query: 523 PEESRSYGRNHLREESSRTE 542
E + R R+ +T+
Sbjct: 197 KERRKKKERKKDRKTDRQTD 216
Score = 62.8 bits (151), Expect = 3e-09
Identities = 55/273 (20%), Positives = 112/273 (41%), Gaps = 56/273 (20%)
Query: 203 RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPR 262
R+ + + L+ S S K + S KK+R+ ++++ + + ++K R
Sbjct: 8 RAAVKLNTELQMVSCSHISKPCTQRESERKKERR---------EREKRKREREKERKRER 58
Query: 263 TPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQ 322
GKK K+K K ++R +E+ R K+R + + +REK + R +
Sbjct: 59 --------------GKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKR 104
Query: 323 HHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSP 382
R + + + RKR
Sbjct: 105 ERKQRGRRERKKKKERKERERENKQRRERKR---------------------------KK 137
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
+RK+ + R +E+G+ + +R + + R ++RE R +R +E++ +E RE ++++
Sbjct: 138 RRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKK 197
Query: 443 SRDHRDDREPRDGRDRRDARDTRDR--RELRDS 473
R + +R+ +DR+ R T + R LR+S
Sbjct: 198 ERRKKKERK----KDRKTDRQTDSQVFRPLRES 226
Score = 62.4 bits (150), Expect = 3e-09
Identities = 52/252 (20%), Positives = 105/252 (41%), Gaps = 17/252 (6%)
Query: 388 PPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHR 447
P R R+K R + E+ + ++ +R RGK++++K + ER E+++ ++
Sbjct: 28 PCTQRESERKKERREREKRKREREKERKRE---RGKKEKKKRKKRERGKERERKR-KERE 83
Query: 448 DDREPRDGRDRRDARDTRDRRE--LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH 505
R+ R ++RR + + +RE R R+ + +E ++ R+ K+ R+ + R R
Sbjct: 84 KQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK--RKKRRKK 141
Query: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565
R R+ R + + R + E +R E + E + R E + +R R
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201
Query: 566 RVPELPEKGSRGSRGSQI-----DSHSSNSNYHDSWETRSSYPERDRYPERDN----RDQ 616
+ ++ + SQ+ +S + + R + D +P + N R +
Sbjct: 202 KKERKKDRKTDRQTDSQVFRPLRESAFNRVTVTGVFRYRIFHTGLDHFPIKTNILLSRHE 261
Query: 617 ARDSSFERRHGE 628
D E GE
Sbjct: 262 VNDGEIEVNDGE 273
Score = 61.2 bits (147), Expect = 7e-09
Identities = 50/234 (21%), Positives = 96/234 (41%), Gaps = 21/234 (8%)
Query: 1121 ATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQH 1180
A ++ AA +T +S S T E +K R R ++ + +
Sbjct: 4 AISSRAAVKLNTELQMVSCSHISKPCTQR----ESERKKERREREKRKREREKERKRERG 59
Query: 1181 RKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKS 1240
+K +++ G R + + R + R + ++ G R+R+K K
Sbjct: 60 KKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKK- 118
Query: 1241 LEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ 1300
ERK R + K+ R R+ R +R R+ + + R++ +
Sbjct: 119 -----ERKERERENKQRR-ERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKR 172
Query: 1301 ERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRD 1354
ER+R E +ERER+ R R++E R ++R + +ER+++R+ D++ D
Sbjct: 173 ERNRKERKKERERKERRERKKE----------RKKERRKKKERKKDRKTDRQTD 216
Score = 61.2 bits (147), Expect = 7e-09
Identities = 40/181 (22%), Positives = 77/181 (42%), Gaps = 2/181 (1%)
Query: 386 QSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRD 445
Q + RE+ + ER + R ++ + R KR+R K+ +R+ + Q R
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 446 HRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAH 505
++ R+ + + +R+ R R RRE R + R RE + R ++ + R + ++
Sbjct: 91 EKERRKRKKEKKKRE-RKQRGRRE-RKKKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 506 DYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRG 565
++R R+ RK+ E + RN + R R + R + R + R +
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKD 208
Query: 566 R 566
R
Sbjct: 209 R 209
Score = 60.1 bits (144), Expect = 2e-08
Identities = 46/218 (21%), Positives = 96/218 (44%), Gaps = 55/218 (25%)
Query: 278 KKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQ 337
++ KE+ + + + E+K R ++RG++ ER+R++R+K R
Sbjct: 49 EREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR---------------------- 86
Query: 338 SGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMRE 397
+ RRKR + +RKQ R R +E
Sbjct: 87 -----KERREKERRKRKKEKKKR----------------------ERKQRGRRERKKKKE 119
Query: 398 KGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRD 457
+ ER ++ RR +R+ R K+ R++ RE+ ++++ + +++RE + R+
Sbjct: 120 R----KERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERN 175
Query: 458 RRDARDTRDRRELRDSRDMR--DSREMRDYSRDTKESR 493
R++ + R+R+E R+ + R + R+ ++ +D K R
Sbjct: 176 RKERKKERERKERRERKKERKKERRKKKERKKDRKTDR 213
Score = 57.0 bits (136), Expect = 1e-07
Identities = 42/190 (22%), Positives = 83/190 (43%), Gaps = 11/190 (5%)
Query: 1258 EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRD 1317
+P S+R+ R +R + R + + +ER + + +ERE++
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR 86
Query: 1318 TRQREWDRDADKDWPRNRDRDRLRERERERERDKR---RDLDRERERLISDSVERDRDRD 1374
+RE +R K + R+R + RER+++++++ R+ + RER ++ R ++
Sbjct: 87 KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146
Query: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
R R E + E ++ K E E +R+ R KER ++ ++ K E
Sbjct: 147 RKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRER--------KKERKKE 198
Query: 1435 RTESLEAGDD 1444
R + E D
Sbjct: 199 RRKKKERKKD 208
Score = 54.3 bits (129), Expect = 9e-07
Identities = 44/183 (24%), Positives = 87/183 (47%), Gaps = 16/183 (8%)
Query: 1270 SRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADK 1329
S+ + R S + +R+ + ++R +ER + E + ++RER R+R
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERER-------- 77
Query: 1330 DWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDR-DRTFESSQ---IE 1385
+ ++R++ R+ RE+ER KR+ ++RER ER + ++R +R E+ Q +
Sbjct: 78 ---KRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK 134
Query: 1386 SVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKS-ERTESLEAGDD 1444
KR + K E +R+ E R+ +++ +++ + +E K ER E E +
Sbjct: 135 RKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194
Query: 1445 ESK 1447
K
Sbjct: 195 RKK 197
Score = 54.3 bits (129), Expect = 9e-07
Identities = 52/238 (21%), Positives = 103/238 (43%), Gaps = 50/238 (21%)
Query: 787 QRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSP 846
QR+ E K + R+ + KRE +E + R +++K KKR R ++ ++R+E
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERG------KERERKRKER-- 82
Query: 847 DSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE 906
+K K R R +E R + K+E +K ERK+ RR
Sbjct: 83 ---------EKQRKER------REKERR-------------KRKKEKKKRERKQRGRR-- 112
Query: 907 EQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKP 966
E K+K +++RE + E R + + ++ + K++ K ++K
Sbjct: 113 --ERKKKKERKERERENKQRRERKRKKRR----------KKKRRKERKREKERGKRERKR 160
Query: 967 IKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQ 1024
K+KKE+ N + ++ + ++ +K++ E+++KK + +D + Q
Sbjct: 161 KKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQ 218
Score = 51.2 bits (121), Expect = 8e-06
Identities = 45/193 (23%), Positives = 89/193 (46%), Gaps = 7/193 (3%)
Query: 872 ESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSR 931
E + +S SH+++ R E ++ +E +R E+E K + +K++ + R
Sbjct: 16 ELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER 75
Query: 932 MRAQDIIGHHQSEDRETSDRAHDENKKK--AKIQKKPIKKKKEDDVGIERGNIETTSEDG 989
R + + E RE R + KKK K + + +KKK++ ER N +
Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR 135
Query: 990 QVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKE-ELVEMCNG 1048
+ K+ +KK+ E+KR+K +G + ++ ++ ++K+ R KE E E
Sbjct: 136 K----KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRER 191
Query: 1049 KNGILEDSQKKED 1061
K ++ +KK++
Sbjct: 192 KKERKKERRKKKE 204
Score = 49.3 bits (116), Expect = 3e-05
Identities = 46/222 (20%), Positives = 90/222 (40%), Gaps = 23/222 (10%)
Query: 96 VDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGD 155
++TE Q + S P + S + +E K +ER E + E + E +
Sbjct: 13 LNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKK---- 68
Query: 156 INYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKS 215
E E +R++ +RE + E+ E+R+ KKE + + +K
Sbjct: 69 ------RERGKERERKRKEREKQRKERREKERRKR---KKEKKKRERKQRGRRERKKKKE 119
Query: 216 SKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIA 275
K +R++ + KK RK ++R + + K++G R E+
Sbjct: 120 RKERERENKQRRERKRKKRRK----------KKRRKERKREKERGKRERKRKKRKKEERE 169
Query: 276 LGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRST 317
++ K + K+R ++ R+ K + R++++R K R T
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKT 211
Score = 49.3 bits (116), Expect = 3e-05
Identities = 45/215 (20%), Positives = 95/215 (44%), Gaps = 15/215 (6%)
Query: 1270 SRSHSSRRSSP-ESDRQVHSRSGSFDSRDRLQERDRYEHDRE------RERERRDTRQRE 1322
S SH S+ + ES+R+ R R+R +ER R +E RER + R+R
Sbjct: 21 SCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKR- 79
Query: 1323 WDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD----RDRDRT 1378
++ +K R+++R R+R++E+++ +R+ R + + ER+R+ R+R R
Sbjct: 80 --KEREKQRKERREKER-RKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRK 136
Query: 1379 FESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTES 1438
+ +R K G+ ER + ++ +ER K+ + +E + ++
Sbjct: 137 KRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERK 196
Query: 1439 LEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEI 1473
E + + D + + + P+ + + +
Sbjct: 197 KERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRV 231
Score = 48.5 bits (114), Expect = 5e-05
Identities = 44/188 (23%), Positives = 78/188 (41%), Gaps = 12/188 (6%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHRE---KEDIKITK 131
+R ER + RER K KR+ ++R +E RK+ RG+ RE KE K K
Sbjct: 31 QRESERKK-ERREREKRKREREKERKRERGKKEKKK--RKKRERGKERERKRKEREKQRK 87
Query: 132 ERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEI 191
ER + + + + R+ G E + +R++ +RE + + +KR +
Sbjct: 88 ERREKERRKRKKEKKKRERKQRGR------RERKKKKERKERERENKQRRERKRKKRRKK 141
Query: 192 IIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNS 251
+KE E R K RK + K++ + +++RK ++R
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201
Query: 252 KTNQSKKK 259
K + K +
Sbjct: 202 KKERKKDR 209
Score = 47.8 bits (112), Expect = 8e-05
Identities = 36/173 (20%), Positives = 82/173 (47%), Gaps = 10/173 (5%)
Query: 856 DKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS 915
++ ++ R + R +E E ++ + +E ++ ERK R + +E +EK
Sbjct: 35 ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKER 94
Query: 916 SVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDV 975
K++++ + E + ++ + ++RE ++ E K+K + +KK K++K +
Sbjct: 95 R--KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK- 151
Query: 976 GIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKK 1028
ERG E + KK +++K E+ RK+ K + + + ++ +KK
Sbjct: 152 --ERGKRERKRK-----KRKKEEREKKRERNRKERKKERERKERRERKKERKK 197
Score = 42.7 bits (99), Expect = 0.003
Identities = 48/239 (20%), Positives = 94/239 (39%), Gaps = 48/239 (20%)
Query: 80 RPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEE 139
+P K +R++ + ++R E +KE + + RE+ KER + +E
Sbjct: 27 KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRER-----GKERERKRKE 81
Query: 140 ENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSP 199
+ + R E +R+K ++E K E++ +RE KKE
Sbjct: 82 REKQRKERR------------------EKERRKRKKEKKKRERKQRGRRER-KKKKERKE 122
Query: 200 EVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKK 259
+K +K K +RK + K++RK ++ K + +KK
Sbjct: 123 RERENKQRRERKRKKRRKKKRRKERKREKERGKRERK-----------RKKRKKEEREKK 171
Query: 260 GPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTS 318
R K+ K++ + K+R E K K+R + ER+++++ ++ S
Sbjct: 172 RERN-------------RKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDS 217
Score = 41.6 bits (96), Expect = 0.006
Identities = 48/208 (23%), Positives = 82/208 (39%), Gaps = 29/208 (13%)
Query: 56 TCRFVHGPSPRGKGYSSNYRRSPERPTGDLRERMKN-KRQDVDTEPQKRNTEESSSPVRK 114
+C + P + + RR E+ RER K KR+ E +KR E
Sbjct: 21 SCSHISKPCTQRESERKKERREREKRK---REREKERKRERGKKEKKKRKKRE------- 70
Query: 115 ESSRGRHRE---KEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQ 171
RG+ RE KE K KER + + + + R+ G E + +R+
Sbjct: 71 ---RGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGR------RERKKKKERK 121
Query: 172 KIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSAS 231
+ +RE + + +KR + +KE E R K + K K++ K +
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREKERGK------RERKRKKRKKEEREKKRERN 175
Query: 232 KKDRKTSAVSSPLLDQQRNSKTNQSKKK 259
+K+RK ++++ K + KKK
Sbjct: 176 RKERKKERERKERRERKKERKKERRKKK 203
Score = 39.3 bits (90), Expect = 0.030
Identities = 46/202 (22%), Positives = 79/202 (39%), Gaps = 15/202 (7%)
Query: 64 SPRGKGYSSNYRRSPERPTGDLRER-------MKNKRQDVDTEPQKRNTEESSSPVRKES 116
S R K +R ER RER K + + + E +++ E+ R++
Sbjct: 34 SERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 117 SRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRE 176
R R +EK+ + + E +++ E R++ + K +K ++E
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRE-RKRKKRRKKKRRKERKREKE 152
Query: 177 LMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRK 236
K E++ ++++E KK R K R+ K +RK + KKDRK
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKK--ERKKERRKKKERKKDRK 210
Query: 237 T-----SAVSSPLLDQQRNSKT 253
T S V PL + N T
Sbjct: 211 TDRQTDSQVFRPLRESAFNRVT 232
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 131 bits (329), Expect = 6e-30
Identities = 127/576 (22%), Positives = 263/576 (45%), Gaps = 40/576 (6%)
Query: 516 HRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRND-RMGRSRG-----RVPE 569
H+K D Y EE R+ L E R I NE + +E++ R+ S V E
Sbjct: 154 HKKADRYIEELTKE-RDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKE 212
Query: 570 LPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGER 629
L K R + +N+ + W E+++ + R R E
Sbjct: 213 LKRKLERAK--FLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEE-RLREQEG 269
Query: 630 DRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRER 689
R+ E+ +R +R Q + + E RE++++ +++ E+ + + E+ RE+
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 690 ERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKER 749
E + R+ +R E+E+++ + + R++E ER E+D +R RE+E ER RE+E+
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQE---ERMWEQD-----ERLREKE-ERMREQEK 380
Query: 750 EREREERERERERERERERERERERERARERDKERERQRD--WEDKDKGRDDRR--EKRE 805
E+EE+ +E ER RERE++ E E RE++++ ++Q + WE ++K +R E++E
Sbjct: 381 MWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 806 EIREDRNPRDGHD---ERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
++ E ++ + E++ K R + E ++ ++ + + + ++ EK R
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW----EQEEKMR 496
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVS--SVDKQ 920
Q + QE R +++ R +E+ + +++E R ++ + +EK + +K
Sbjct: 497 DQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 921 REQTEILE-SSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIER 979
RE+ + E +MR ++ + Q E + + E ++K Q++ +++++E E
Sbjct: 557 REEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEE 616
Query: 980 GNIETTSED----GQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPP 1035
E ED + ++ +K + E+K + + +E+ +Q +K +G
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEE-- 674
Query: 1036 ITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDED 1071
+E+ +M + + E +K W E+
Sbjct: 675 -KMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEE 709
Score = 122 bits (306), Expect = 3e-27
Identities = 104/523 (19%), Positives = 234/523 (44%), Gaps = 41/523 (7%)
Query: 535 REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHD 594
+EE R + + + E + + +R+ G++ E EK R + + +
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKE 298
Query: 595 SWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDEL 654
E + + ++ E++ + ++ + + R++ R +Q + Q D+
Sbjct: 299 LREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQE 358
Query: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARE 714
ER ++ER ++ +ER RE+++ E++ E+ +E ER REREK+ E E RE
Sbjct: 359 ERMWEQDERLREK-----EERMREQEKMWEQE---EKMQEEERIREREKKMREEEETMRE 410
Query: 715 REREREKERDRERDRDRDHDRERERERERDREKEREREREERER---ERERERERERERE 771
+E + +K+ + +++ +++ ++++ E+E+ +E+ E+ + E+ R++E
Sbjct: 411 QEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWG 470
Query: 772 RERERARERDKERERQRDWEDKDKGRDDR-----------------REKREEIREDRNPR 814
+E++ R+ + + WE ++K RD REK E +RE +
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 815 DGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR 874
++ + +K+ + + + Q K R E ++ +K R +++R QE +
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERM--------REREKKMREEEEMMREQEEK 582
Query: 875 SLSPSH-LTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEIL--ESSR 931
+ E + W++E++ E++E + +E++E + DK +EQ E++ + +
Sbjct: 583 MQEQEEKMREQEEKMWEQEEKMQEQEE--KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEK 640
Query: 932 MRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQV 991
M+ Q+ Q E + E ++K + Q++ +++++E G E E +
Sbjct: 641 MQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQ 700
Query: 992 FSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTP 1034
GQ++K ++ K + EE + K+K R P
Sbjct: 701 EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLP 743
Score = 121 bits (303), Expect = 6e-27
Identities = 99/527 (18%), Positives = 229/527 (43%), Gaps = 42/527 (7%)
Query: 416 RREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRD-SR 474
R+E+ +++++ +EE+ + Q++ RE + R++ R +ELR+ +
Sbjct: 238 RQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEK 297
Query: 475 DMRDSREMRDYSRDTKESR----DPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYG 530
++R+ +++R+ +E + + ++ +R E K+ E+
Sbjct: 298 ELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQ 357
Query: 531 RNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNS 590
+ E+ R + E E + + R+ E +K +
Sbjct: 358 EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQK 417
Query: 591 NYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGR 650
+ WE ++ R PE+ E+ + ++ E+ IR Q
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQK----------EKLWEQEKMQEQEEKIWEQEEKIRDQEE 467
Query: 651 NDELERDERREERRVDRVDDRRDERARERDRERER-DRERERERERERDREREKERELER 709
E+ R+E+ ++ D ++ + RD+E++ D+E + ER RE+E+ ++
Sbjct: 468 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 710 ERAREREREREKERDRERDRDRDHDRERERERERDREKERE-REREERERERERERERER 768
+ ++ E+ RE+++ +E+++ E+ RE ER RE+E++ RE EE RE+E + + +
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 587
Query: 769 ERERERER---ARERDKERERQRDWEDKDK----GRDDRREKREEIREDRNPRDGHDERK 821
E+ RE+E +E + + ++ WE ++K +D+ +++EE+ ++ + E K
Sbjct: 588 EKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Query: 822 ---SKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSP 878
+++ R + Q K + + + + EK R + +R QE +
Sbjct: 648 MWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEK---- 703
Query: 879 SHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE 925
W +E++ ++E + + ++E++EK + Q+E+ +
Sbjct: 704 ---------MWGQEEKMWGQEE--KMWGQEEMREKEERIRDQKEKMQ 739
Score = 111 bits (278), Expect = 5e-24
Identities = 87/465 (18%), Positives = 208/465 (44%), Gaps = 23/465 (4%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSS 442
Q K+ + + +K + E Q + + +E+ +++ + +EER +EQ++
Sbjct: 288 QEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQM 347
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
+++ RD +R +D R R + R+ E + ++ + R+ R+ +
Sbjct: 348 ---REQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE-REKKMRE 403
Query: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
+ R++E + ++E+ + +E + + + L E+ + + + + + + R
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 563 SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSF 622
+ + +K R + + + + + + + +R E+D R + +
Sbjct: 464 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREK---- 519
Query: 623 ERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRE 682
E R E+ + +E R + Q + + ++ REE ER RER+++
Sbjct: 520 EERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-----------ERMREREKK 568
Query: 683 RERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERE---R 739
+ E RE+E + + EK RE E + + E+ +E+E ++ ++E E +
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628
Query: 740 ERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDD 799
E+E ++ E+ +E+ E+ E+E + + E+ RE+ + + E+ R+ E+K +G+++
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Query: 800 R-REKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRRE 843
+ RE+ E++R G +E+ + + G R+ +R R+
Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRD 733
Score = 62.8 bits (151), Expect = 3e-09
Identities = 76/501 (15%), Positives = 188/501 (37%), Gaps = 40/501 (7%)
Query: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE----------DIKITKERTP 135
++ K RQ+ Q+ E +R++ R R +EKE K+ ++
Sbjct: 252 KQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQ 311
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
E+E WE + + + L + K+ + Q + M+ ++E M +++E + +K
Sbjct: 312 MQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREK 371
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQ 255
E +++ + +R+ + + ++++ + +Q + Q
Sbjct: 372 EERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK------MQKQEENMWEQ 425
Query: 256 SKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKD---RGRDFERQREKRD 312
+K+ + P E + +K +E+ + EEK RD ++ + + RQ + R+
Sbjct: 426 EEKEWQQQRLPEQ--KEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMRE 483
Query: 313 KPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
+ + + + +R R R +Q+ +
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQ 543
Query: 373 PYPSHSLSSPQRKQSPPRHR---SPMREKGR--HDHERTSQSHDRRHERREDTRGKRDRE 427
+ ++ + R R MRE+ + E Q + + +E+ +++ +
Sbjct: 544 EQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Query: 428 KDSREEREYEQDQSSSRDHRDDR---------EPRDGRDRRDARDTRDRRELRDSRD-MR 477
+EE+ +EQ++ +D+ E + ++ + ++R+ + MR
Sbjct: 604 MQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMR 663
Query: 478 DSRE----MRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNH 533
+ E + R+ +E ++ + R +E + ++E + +E + +G+
Sbjct: 664 EQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE 723
Query: 534 LREESSRTEIRNESRNESRSE 554
+RE+ R + E E E
Sbjct: 724 MREKEERIRDQKEKMQERLPE 744
Score = 56.2 bits (134), Expect = 2e-07
Identities = 63/267 (23%), Positives = 117/267 (43%), Gaps = 34/267 (12%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
RD+E E+ G+ K Q K E + R + E +R
Sbjct: 463 RDQE-----EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE-ERMWEQDERL 516
Query: 1293 FDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
+ +R++E+ + E+ RE + T+++E K W + +++RE ER RER+K+
Sbjct: 517 REKEERMREQKKMWQQEEKMREEKKTQEQE-----KKTWDQ---EEKMREEERMREREKK 568
Query: 1353 ----RDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRD 1408
++ RE+E + + E+ R+++ ++ +E Q E ++ E K+ + E+ E D
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQE-EKMWE--QEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 1409 SLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDD 1468
+ +E M + +Q EE E+ E + + E K+ + G E
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEE-KMWEQEEKMR--EQEEKMREQEEKMQGQEEKMR----- 677
Query: 1469 ELDEILAGDAEKREDQQD-----EEKM 1490
E +E + G EK +Q++ EEKM
Sbjct: 678 EQEEKMQGQEEKMREQEEKMRGQEEKM 704
Score = 46.2 bits (108), Expect = 2e-04
Identities = 48/281 (17%), Positives = 114/281 (40%), Gaps = 17/281 (6%)
Query: 1216 RSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS 1275
+ G + +++ R RE+ K L E++ + + K+ ++++
Sbjct: 267 QEGKMREQEEKMRRQEKRLREQEKELR---EQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWD---RDADKDWP 1332
+ + ++ ++ +++E+++ D+E +D R RE + R+ +K W
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 1333 RNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRD---RDRDRTFESSQIESVKR 1389
+ ++++E ER RER+K+ + E R + +++ + ++ ++ ++ K
Sbjct: 384 QE---EKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKE 440
Query: 1390 CEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLD 1449
+ E E++ + ++ D+E M G + K E +E D
Sbjct: 441 KLWEQEKMQEQEEKIWEQEEKIRDQEEM---WGQEKKMWRQEKMREQEDQMWEQEEKMRD 497
Query: 1450 DAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKM 1490
+ +E D+ L E E+++ Q EEKM
Sbjct: 498 QEQKMWDQEERMWE--QDERLREKEERMREQKKMWQQEEKM 536
Score = 43.1 bits (100), Expect = 0.002
Identities = 43/208 (20%), Positives = 95/208 (45%), Gaps = 10/208 (4%)
Query: 1234 DREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDS-RSHSSRRSSPESDRQVHSRSGS 1292
+ EK++ E K ++++ K P T++ +++ R R + R+ +
Sbjct: 200 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM-- 257
Query: 1293 FDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKR 1352
+ +RL+E++ ++E + R++ R RE +++ + R++ +LRE+E + + +
Sbjct: 258 WRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEE 317
Query: 1353 RDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLAL 1412
+ ++E + E R +R +E Q + ++ E K+ + ER E R L
Sbjct: 318 KMWEQEEK---MREQEEKMWRQEERLWE--QEKQMREQEQKMRDQEERMWEQDER--LRE 370
Query: 1413 DKERMDKDLGSVQGFEETNKSERTESLE 1440
+ERM + + E+ + ER E
Sbjct: 371 KEERMREQEKMWEQEEKMQEEERIRERE 398
Score = 40.8 bits (94), Expect = 0.010
Identities = 38/191 (19%), Positives = 88/191 (46%), Gaps = 16/191 (8%)
Query: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
+R+ R RE+ K + E K R ++ K E + T + R R + R
Sbjct: 514 ERLREKEERMREQKKMWQ--QEEKMR-EEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 1285 QVHSRSGSFDSRDRLQE---RDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLR 1341
+ + + + QE R++ E E+E + ++ ++ W+++ +K W + + D+++
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQE-EKMWEQEEE-DKMQ 628
Query: 1342 ER-----ERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEG 1396
E+ E+E + ++ + E+E + + E+ R+++ Q E ++ E K++G
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKM---QGQEEKMREQEEKMQG 685
Query: 1397 EHERDLESTSR 1407
+ E+ E +
Sbjct: 686 QEEKMREQEEK 696
Score = 38.1 bits (87), Expect = 0.067
Identities = 31/165 (18%), Positives = 69/165 (41%), Gaps = 10/165 (6%)
Query: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEE----SSSPVRKESSRGRHREK----EDIKIT 130
E+ T D E+M+ + + + E + R EE ++++ + R +E+ ++ K+
Sbjct: 546 EKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQ 605
Query: 131 KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKI--QRELMKLEQENMEKR 188
++ E+E WE +D + E ++ + +K+ Q E M+ ++E M ++
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 189 EEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK 233
EE + +E K+ + + R K +K
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEK 710
Score = 35.8 bits (81), Expect = 0.33
Identities = 57/385 (14%), Positives = 138/385 (35%), Gaps = 41/385 (10%)
Query: 85 LRERMKNKRQDVDT---EPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEEN 141
+RER K R++ +T + +K +E + ++E + R E + E+ E+E
Sbjct: 394 IREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEE 453
Query: 142 VEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEV 201
WE D E+ + K+ Q ++ + E + E+ E++ +++ +
Sbjct: 454 KIWEQEEKIRDQ--------EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 505
Query: 202 VRSKLSPSPSLR-KSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKG 260
LR K + ++K + ++++KT DQ+ + + ++
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 261 PRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPA 320
KK +E+ ++ EEK ++ + E+ RE+ +K
Sbjct: 566 E----------------KKMREEEEMMREQEEKMQEQE------EKMREQEEK------M 597
Query: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
+ + + Q ++ +++ Q
Sbjct: 598 WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMRE 657
Query: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ 440
++ + EK R E+ ++ E+ E RG+ ++ E+ ++++
Sbjct: 658 QEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEK 717
Query: 441 SSSRDHRDDREPRDGRDRRDARDTR 465
++ ++E R RD+++ R
Sbjct: 718 MWGQEEMREKEERI-RDQKEKMQER 741
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 126 bits (317), Expect = 1e-28
Identities = 157/778 (20%), Positives = 317/778 (40%), Gaps = 87/778 (11%)
Query: 392 RSPMREKGRHDHERTS-QSHDRRHERREDTRGKRDREKDSREEREYE-------QDQSSS 443
R RE+ R + ER + Q +D E R +R R++ R+++E E Q + ++
Sbjct: 11 RRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA 70
Query: 444 RDHRDDREPR--------DGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP 495
++ D E + +G D + RRE R + ++++ E + + DP
Sbjct: 71 QNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQ-------KEFDP 123
Query: 496 RDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEI 555
+ ++ R + DT E T EE + E + T ++ +N+ R
Sbjct: 124 TITDASLSLPSRRMQN--DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAE 181
Query: 556 RNDRMGRSRGRVPELPEKGSRGSRG-SQIDSHSSNSNYHDSWET-----RSSYPERDRYP 609
N + + + E EK RGS G +Q++ ET ++ +
Sbjct: 182 ENKKEDKEKEEEEE--EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRND-ELERDERREERRVDRV 668
+ + R+Q D E H E+ +++ER + + + + R + E+D++ + R R+
Sbjct: 240 QEEEREQGSD---EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA-RI 295
Query: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
+ A+ER+R +RER RE E+ ER++ +E E+ A ER+R +E+E+ +
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQR 788
R R + E+ ER R + E E+ + E ++ ++ E++ + + + E++ +
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
Query: 789 DWEDKDKGRDDR-----------------REKREEIREDRNPRDGHDERKSKKRYRNEGS 831
W ++ K ++D+ + KRE+++ED+ P +E K +K +++
Sbjct: 416 KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDK-PTFKKEEIKDEKIKKDK-- 472
Query: 832 PSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLL---SQVVRPQESRSLSPSHLTEDRQ-- 886
P++ K + S + + H+L + RP S+ Q
Sbjct: 473 -EPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVE 531
Query: 887 -GRWKEEDRKPERKESSRRYEEQELKEKVSSVD------KQREQTEILESSRMRAQDIIG 939
G+ EE R+ + S +E+ + K++ ++++ K+ E+ ++LE R +
Sbjct: 532 AGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEA 591
Query: 940 HHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVF------- 992
+ + E R +E +++ + +K ED + ++ + + G
Sbjct: 592 DRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 651
Query: 993 ----SPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNG 1048
S +K KS + SK DS + +A + K P P +L G
Sbjct: 652 FLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKP---AASDLPVPAEG 708
Query: 1049 KNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPP 1106
I S ++ FS + P++ ++ T +P + P P P
Sbjct: 709 VRNI--KSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLTKTPDGNKSPAPKP 764
Score = 124 bits (310), Expect = 9e-28
Identities = 142/667 (21%), Positives = 280/667 (41%), Gaps = 46/667 (6%)
Query: 418 EDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR 477
+D +R+ + REE E ++ + + + DD E RR AR R LR ++
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQER----LRQKQEEE 57
Query: 478 DSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREE 537
++ D ++ P + T + + + + EE R + L+E
Sbjct: 58 SLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERR---QKRLQEA 114
Query: 538 SSRTEIRNESRNESRSEIRNDRM--GRSRGRVPELPEKG-SRGSRGSQIDSHSSNSNYH- 593
R + + + ++ + + RM + E EK SR R ++ + +Y
Sbjct: 115 LERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQK 174
Query: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE 653
+ W + D+ E + ++ + S E + Q + + +
Sbjct: 175 NDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
Query: 654 LERDERREERRVDRVDDRRDERARERDRER-ERDRERERERERERDREREKERELERERA 712
E ++ EER + E+ E D+ER E +R R ERER + E+++++ ERA
Sbjct: 235 SEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIK-AEQDKKIADERA 293
Query: 713 REREREREKERDRERDRDRDHDRERERER----ERDREKERE-REREERERERERERERE 767
R E+ ++RER + +R RE E+ ER R KE E R EER+R +E E+
Sbjct: 294 RIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 353
Query: 768 RERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYR 827
ER+R +E + +ER+R R E+++K + + +++ +++ E ++ + K +
Sbjct: 354 EERQRIKEEEKRAAEERQRARA-EEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK 412
Query: 828 NEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG 887
EG K E D + K + ++V +E L ED+
Sbjct: 413 IEG--------KWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK-------LQEDKP- 456
Query: 888 RWKEEDRKPERKESSRRYEEQELKEKVSS-VDKQREQTEILESSRMRAQDIIGHHQSEDR 946
+K+E+ K E+ + +++E KE+V S +D+++ TE+ + + H ++
Sbjct: 457 TFKKEEIKDEKIK-----KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFS 511
Query: 947 ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKK 1006
RA + K+ + K+ E+ + R ET SE+ + K+ + +E+
Sbjct: 512 RPGGRASVDTKEAEGAPQVEAGKRLEE---LRRRRGETESEEFEKLKQKQQEAALELEEL 568
Query: 1007 RKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSD 1066
+KK + + +EE ++ +++ + K L E + E ++K++
Sbjct: 569 KKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRA--EAAEKRQKMPEDG 626
Query: 1067 WSDEDVP 1073
SD+ P
Sbjct: 627 LSDDKKP 633
Score = 83.2 bits (204), Expect = 2e-15
Identities = 113/666 (16%), Positives = 265/666 (39%), Gaps = 75/666 (11%)
Query: 86 RERMKNKRQDVDTEPQK----RNTEESSSPVRKESSRGRH------REKEDIKITKERTP 135
RE + KR+++ E ++ RN ++ R+ R R +E+E + ++
Sbjct: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVE 67
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
+ + +V E + + N + D + R++ +R+ K QE +E++ K
Sbjct: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQ--KRLQEALERQ------K 119
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQ--QRNS-- 251
E P + + LS PS R + + + +++ K + + + + + + Q+N
Sbjct: 120 EFDPTITDASLS-LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 252 KTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRG--RDFERQRE 309
++KK+ P+ ++G+ +V+ +EEKT + ++ + +
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGEN-----QVEVMVEEKTTESQEETVVMSLKNGQI 233
Query: 310 KRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369
++P+ Q IS HH + + R R + +R ++
Sbjct: 234 SSEEPKQEEEREQGSDEIS--HHEKMEEE----DKERAEAERARLEAEERERIKAEQDKK 287
Query: 370 SASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR--- 426
A Q R + RE+ R + +R ++ R E + +R R
Sbjct: 288 IADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKE 347
Query: 427 -EKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDAR-DTRDRRELRDSRDMRDSREMRD 484
EK + EER+ +++ E R +R+ AR + ++ ++ + + + E +
Sbjct: 348 EEKRAAEERQRIKEE----------EKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
Query: 485 YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
++TK + + + EG+ + K+ + + + E+ ++ + +
Sbjct: 398 AMQETKIKGEKVEQKI----------EGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK 447
Query: 545 NESRNE-----SRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599
E E + EI+++++ + + E+ R +++ S + H T
Sbjct: 448 REKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTE 507
Query: 600 SSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER 659
+++ D ++ E G+R R R + S ++L++ ++
Sbjct: 508 NTFSRPGGRASVDTKEAEGAPQVEA--GKRLEELRRRRGETESEEF------EKLKQKQQ 559
Query: 660 REERRVDRVDDRRDERARERDRERERDRERERERE-RERDREREKERELERERARERERE 718
++ + +R+ER + + E +R ++ E +R+ RE + +R + E+ER RA E+
Sbjct: 560 EAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKR 619
Query: 719 REKERD 724
++ D
Sbjct: 620 QKMPED 625
Score = 76.3 bits (186), Expect = 2e-13
Identities = 119/656 (18%), Positives = 238/656 (36%), Gaps = 86/656 (13%)
Query: 732 DHDRERERERERDREKERERER--EERERERERERERERERERERERARERDKERERQR- 788
D +R RE R++ E E ER +R + E E RER R +ER R++ +E +
Sbjct: 3 DFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQV 62
Query: 789 -------------DWEDKDKGRDDRREKREEI--------REDRNPRDGHDERKSKKRYR 827
D E K + + E +E RE+R + + + +K +
Sbjct: 63 TDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFD 122
Query: 828 NEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG 887
+ + P RR + + A N +K EK + +E+ +++ S+ D
Sbjct: 123 PTITDASLSLPSRRMQ---NDTAENETTEKEEKSESRQERYEIEETETVTKSYQKND--- 176
Query: 888 RWKEEDRKPERKESSRRYEEQELKEKVSSV-------------DKQREQTEIL------- 927
W+ D + +KE + EE+E K K S+ + +E+T ++
Sbjct: 177 -WR--DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQI 233
Query: 928 -------ESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERG 980
E R + D I HH+ + E +RA E + +++ IK +++ + ER
Sbjct: 234 SSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERA 293
Query: 981 NIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKE 1040
IE + + ++ +++++ E++R + + + + ++ +K+ I KE
Sbjct: 294 RIEAEEK----AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRI--KE 347
Query: 1041 ELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSL 1100
E + I E+ ++ + ++E+ + E + + +
Sbjct: 348 EEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGE 407
Query: 1101 LPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKC 1160
TA + TF E+ +
Sbjct: 408 KVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDE- 466
Query: 1161 HRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNR-SHTSGRLRSP----SNDSAH 1215
+++K + P ++ RK + S G +++ HT P S D+
Sbjct: 467 ---KIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 523
Query: 1216 RSGDDQSGRKRVLHSGSRDREKTKSLEITG-ERKSRIDQLKRGEPSRSTSSDRQDSRSHS 1274
G Q + L R R +T+S E ++K + L+ E + R+
Sbjct: 524 AEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEE 583
Query: 1275 SRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKD 1330
RR E+DR++ +E+ R + + ER R ++++ D D
Sbjct: 584 QRRKQEEADRKLREE----------EEKRRLKEEIERRRAEAAEKRQKMPEDGLSD 629
Score = 54.3 bits (129), Expect = 9e-07
Identities = 52/279 (18%), Positives = 112/279 (40%), Gaps = 14/279 (5%)
Query: 1129 SFSTSAITISTSATPTNTTNN--TFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQ 1186
+ + +++++ + +T N T E S + R +E+ ET + + R +
Sbjct: 124 TITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEEN 183
Query: 1187 KRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGE 1246
K+ G + + +S + V+ S + ++ + E
Sbjct: 184 KKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEE 243
Query: 1247 RKSRIDQLKRGEPSRSTSSDRQDSR-----SHSSRRSSPESDRQVHSRSGSFDSRDRL-- 1299
R+ D++ E +R ++ + R E D+++ ++ ++
Sbjct: 244 REQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAA 303
Query: 1300 QERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRER 1359
QER+R E + ERER R + ++ +R K+ ++ ER+R +E +KR +R+R
Sbjct: 304 QERERREAE-ERERMREEEKRAAEERQRIKE----EEKRAAEERQRIKEEEKRAAEERQR 358
Query: 1360 ERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
+ +R R R E +++E KR + E +H
Sbjct: 359 IKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397
Score = 50.4 bits (119), Expect = 1e-05
Identities = 79/362 (21%), Positives = 133/362 (36%), Gaps = 48/362 (13%)
Query: 1146 TTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRK----PMDQKRSSSLGSNR----- 1196
TT NT D + E +++A R+ P S SL S R
Sbjct: 82 TTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDT 141
Query: 1197 SNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKR 1256
+ T +S S + + ++ K + RD E+ K + E + ++ KR
Sbjct: 142 AENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE-EKPKR 200
Query: 1257 G-----------EPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDS---RDRLQER 1302
G E + S + S + + S E +Q R D ++++E
Sbjct: 201 GSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEE 260
Query: 1303 DRYEHDRERERERRDTRQR---EWDRDA----------DKDWPRNRDRDRLRERERERER 1349
D+ + ER R + R+R E D+ +K + R+R ERER RE
Sbjct: 261 DKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREE 320
Query: 1350 DKRRDLDRER----------ERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHE 1399
+KR +R+R ER E+ +R R E + + +R A+ E E +
Sbjct: 321 EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEK 380
Query: 1400 RDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAG 1459
+E R+ +K+ ++ ++G + K E E E KL A G
Sbjct: 381 AKVEEQKRNKQLEEKKHAMQET-KIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEE 439
Query: 1460 EG 1461
+G
Sbjct: 440 KG 441
Score = 47.8 bits (112), Expect = 8e-05
Identities = 65/377 (17%), Positives = 139/377 (36%), Gaps = 49/377 (12%)
Query: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESE 138
E+ RER + + ++ E +KR EE KE + E++ IK ++R E E
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQR--IKEEEKRAAEERQRIKEEEKRAAE-E 355
Query: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVS 198
+ ++ E R + + + +E +++ Q +E+++ + + ++
Sbjct: 356 RQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQ----------LEEKKHAMQETKIK 405
Query: 199 PEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK 258
E V K+ K ++ K +++ +K K A L + + K + K
Sbjct: 406 GEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIK- 464
Query: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTS 318
E I K+ KE+ K ++ + K + +F + K + +
Sbjct: 465 ------------DEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSR 512
Query: 319 PAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHS 378
P G+ + ++G ++ LRR S
Sbjct: 513 PGGRASVDTKEAEGAPQVEAGKRLEE----------------------LRRRRGETESEE 550
Query: 379 LSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQ 438
++KQ +K R + + + ++R ++ E R R+ E+ R + E E+
Sbjct: 551 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
Query: 439 DQSSSRDHRDDREPRDG 455
++ + + R + P DG
Sbjct: 611 RRAEAAEKR-QKMPEDG 626
Score = 45.8 bits (107), Expect = 3e-04
Identities = 48/210 (22%), Positives = 87/210 (41%), Gaps = 35/210 (16%)
Query: 1303 DRYEHDRERERERRDTRQRE-----WDRDADKDWPRNRDRDRLRERERERERDKRRDLDR 1357
D +E RE R++R+ + E + R+ D + R+R R +ER R++ + L +
Sbjct: 2 DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 1358 ERERLISDSVERDRDRDRDRTFESSQIES-----------------VKRCEAKLEGEHER 1400
+++ ++ D + T ++Q+E KR + LE + E
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEF 121
Query: 1401 DLESTSRDSLALDKERMDKDLGSVQGFEETNKSE-RTESLEAGDDESKLDDAHSLGSGAG 1459
D T SL+L RM D + E+ KSE R E E + E+
Sbjct: 122 DPTITDA-SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETET-----------VT 169
Query: 1460 EGYEPISDDELDEILAGDAEKREDQQDEEK 1489
+ Y+ + +E D EK E+++++ K
Sbjct: 170 KSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
Score = 38.5 bits (88), Expect = 0.051
Identities = 82/511 (16%), Positives = 189/511 (36%), Gaps = 36/511 (7%)
Query: 80 RPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEE 139
R D E ++++ Q+R E + V K + R+ E+ K + E EE
Sbjct: 136 RMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEE 195
Query: 140 ENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQEN----MEKREEIIIKK 195
E + G I + V E+ +E K + Q E + + +N E+ ++ ++
Sbjct: 196 EKPK---------RGSIGENQV-EVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE 245
Query: 196 EVSPEVV-RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTN 254
+ S E+ K+ R ++ + ++ + +++D+K + + + +++ +
Sbjct: 246 QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE 305
Query: 255 QSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDF-ERQREKRDK 313
+ +++ E A ++ + K + K EE+ R ++ R ERQR K ++
Sbjct: 306 RERREAEERERMRE--EEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
Query: 314 PRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASP 373
R+ + + + + ++ + + + ++ +
Sbjct: 364 KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKA 423
Query: 374 YPSHSLSSPQRKQSPPRHR--SPMREKGRHD------HERTSQSHDRRHERREDTRGKRD 425
++ +KQ + REK + D E + + E +E+ + D
Sbjct: 424 QEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMD 483
Query: 426 REKDSREEREYEQD-QSSSRDHRDDREPR-DGRDRRDARDTRDRRELRDSRDMRDSREMR 483
R+K E + + + H ++ R GR D ++ ++ + + + R R
Sbjct: 484 RKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRR 543
Query: 484 DYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEI 543
E + + A + + + + R++ EE R +EE+ R
Sbjct: 544 --GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQR-----RKQEEADRKLR 596
Query: 544 RNESRNESRSEIRNDRMGRSRGRVPELPEKG 574
E + + EI R + R ++PE G
Sbjct: 597 EEEEKRRLKEEIERRRAEAAEKR-QKMPEDG 626
Score = 38.1 bits (87), Expect = 0.067
Identities = 60/298 (20%), Positives = 120/298 (40%), Gaps = 35/298 (11%)
Query: 1225 KRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
+R+ + + D E+ + E R++R ++L++ + S D +++ S P+ +
Sbjct: 23 ERIAYQRNDDDEEEAARE--RRRRARQERLRQKQEEESLGQVT-DQVEVNAQNSVPDEEA 79
Query: 1285 QVHSRSGSFDSRDR---LQERDRYEHDRERERERRDTRQREWD---RDADKDWPRNRDRD 1338
+ + + + D L+ R E R++ + RQ+E+D DA P R ++
Sbjct: 80 KTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQN 139
Query: 1339 RLRERE----RERERDKRRDLDRERERLISDSVERDRDRD------RDRTFESSQIESVK 1388
E E E+ ++ + E ++ S +++ RD D+ E + E K
Sbjct: 140 DTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPK 199
Query: 1389 R-------CEAKLEGEHERDLESTSRDSL---ALDKERMDKDLGSVQGFEETNKSER--T 1436
R E +E + E T SL + E ++ QG +E + E+
Sbjct: 200 RGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEE 259
Query: 1437 ESLEAGDDESKLDDAHSLGSGAGEGYEPISDD----ELDEILAGDAEKREDQQDEEKM 1490
E E + E +A E + I+D+ E +E A +R + ++ E+M
Sbjct: 260 EDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317
Score = 35.4 bits (80), Expect = 0.44
Identities = 41/207 (19%), Positives = 80/207 (38%), Gaps = 16/207 (7%)
Query: 84 DLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
+L+++ + +R+ ++ E Q+R EE+ +R+E + R KE+I+ + E ++ E
Sbjct: 567 ELKKKREERRKVLEEEEQRRKQEEADRKLREEEE--KRRLKEEIERRRAEAAEKRQKMPE 624
Query: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
+ DD L +E + + + + + K + I+ K + E
Sbjct: 625 -DGLSDDKKPFKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYT 683
Query: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKD--RKTSAVSSPLLDQQRNSKT-------- 253
S + + S + + + P + K K + SSP N +T
Sbjct: 684 SAIEGTKSAKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVS 743
Query: 254 ---NQSKKKGPRTPSPPPPIPEDIALG 277
N+ K P P P P D+ G
Sbjct: 744 SRINEWLTKTPDGNKSPAPKPSDLRPG 770
Score = 31.2 bits (69), Expect = 8.2
Identities = 25/116 (21%), Positives = 55/116 (47%), Gaps = 6/116 (5%)
Query: 1276 RRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNR 1335
RR ES+ + ++ L+E + +R + E + R+++ +AD+
Sbjct: 542 RRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQ--EEADRKLREEE 599
Query: 1336 DRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCE 1391
++ RL+E E ER +R + +R+++ D + D+ + T + S ++ +R E
Sbjct: 600 EKRRLKE-EIER---RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAE 651
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 125 bits (314), Expect = 3e-28
Identities = 99/359 (27%), Positives = 169/359 (47%), Gaps = 23/359 (6%)
Query: 612 DNRDQARDSSFERRHGERDRRDNRERD---QRPSSPIRHQGRNDELERDERREERRVDRV 668
D +D + + + E+ RR +E +R + + D LE E R+ R +
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITI 62
Query: 669 -------DDRRDERARERDRERERDRERERERERERDREREKERELERERARERE---RE 718
+D ++R E D + ++ +E+ R+ EK +E R R+ E
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 122
Query: 719 REKERDRERDRDRDHDRERER-ERERDREKEREREREERERERERERERERERERERERA 777
R KE++RE +R + H E+++ RE +R+K RE RE RER+R + ER+RERER +
Sbjct: 123 RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERER-KM 181
Query: 778 RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQS 837
RE+ KE QR+ +++++ ++RR++RE RE E S K + S SP +
Sbjct: 182 REQQKE---QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRP 238
Query: 838 PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR---SLSPSHLTEDRQGRWKEEDR 894
P+ R E ++K E+ LLS + +S S + S E G +EE+
Sbjct: 239 PRERFELGDGRKPVK--EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEE 296
Query: 895 KPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
+ E +E EE E +E+ +++ + E+S A+++ SED E + H
Sbjct: 297 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 355
Score = 97.8 bits (242), Expect = 7e-20
Identities = 110/487 (22%), Positives = 191/487 (39%), Gaps = 57/487 (11%)
Query: 457 DRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDT- 515
D +D+ + E+ + R +E + + K S D R + + + RD T
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITI 62
Query: 516 ----HRKEDTYPEESRSYGRNHLR--EESSRTEIRNESRNESRSEIRNDRM----GRSRG 565
+R+ED+ + ++ ++ SR E + ++E R E R R G
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 122
Query: 566 RVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERR 625
RV E + R R + E+D+ R + R+ + E
Sbjct: 123 RVKEKEREHERRKRHRE---------------------EQDKARREWERQKRREMAREHS 161
Query: 626 HGERDRRDNRERDQRPSSPIRHQGR--NDELERDERREERRVDRVDDRRDERARERD-RE 682
ERDR + ER + +R Q + ++ ER+ R EERR +R + RR+ A R RE
Sbjct: 162 RRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKER-EARREVSAHHRTMRE 220
Query: 683 RERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERE-- 740
D+ + R R + EL R +E E+ +ERD D D ER+
Sbjct: 221 DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE-EKMEERDLLSDLQDISDSERKTSSA 279
Query: 741 ----------RERDREKEREREREERERERERERERERERERERERARERDKERERQRDW 790
E + E+E E E E E E E E E E E + + + +
Sbjct: 280 ESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEV 339
Query: 791 EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA 850
+++ D+ RE + R D +S++ G +P+ S ++ PDS A
Sbjct: 340 SEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPA 399
Query: 851 YNSGDDKNEKHRLLSQVVRPQESRSLSP----SHLTEDRQG-RWKEEDRKPERKESSRRY 905
+ + K E + L + Q RS+ + + E G ++ +D+K + + +R
Sbjct: 400 LSPIELKQELPKYLPAL---QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRL 456
Query: 906 EEQELKE 912
+ ++ KE
Sbjct: 457 KMEKEKE 463
Score = 82.4 bits (202), Expect = 3e-15
Identities = 79/332 (23%), Positives = 145/332 (43%), Gaps = 32/332 (9%)
Query: 1167 KVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKR 1226
KV+T +++ + RK ++K N +R S + G+ + R
Sbjct: 9 KVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD---------SKRDSLEEGELRDHRME 59
Query: 1227 VLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQV 1286
+ S R + S+E GE D L P + + ++ R R+ R+
Sbjct: 60 ITIRNSPYRRED-SMEDRGEED---DSLAIKPPQQMSRKEKVHHRKDEKRKEK----RRH 111
Query: 1287 HSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPR---NRDRDRLRER 1343
S S R++E++R R+R RE +D +REW+R ++ R R+RDRL +
Sbjct: 112 RSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQL 171
Query: 1344 ERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLE 1403
ER+RER+++ RE+++ + ER+R R +R E V + ++ ++
Sbjct: 172 ERKRERERKM---REQQKEQREQKERER-RAEERRKEREARREVSAHHRTMREDYSDKVK 227
Query: 1404 ST--SRDSLALDKERMDKDLGSVQGFEETNKSERTESL----EAGDDESKLDDAHSLGSG 1457
++ SR +ER +LG + + K E + L + D E K A S +
Sbjct: 228 ASHWSRSPPRPPRERF--ELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAE 285
Query: 1458 AGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
+G G E ++E +E G + ++++EE+
Sbjct: 286 SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 317
Score = 79.3 bits (194), Expect = 3e-14
Identities = 89/411 (21%), Positives = 162/411 (39%), Gaps = 43/411 (10%)
Query: 281 KEKYKVK--DRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQS 338
K+ +KVK D I ++ + K++ E +R K R + + R H
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGEL--RDHRMEITI 62
Query: 339 GSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREK 398
+S R S + S + PP + S H ++++ RHRS E
Sbjct: 63 RNSPYRREDSMEDRGEEDDSL--AIKPPQQMSRKEKVHHR--KDEKRKEKRRHRSHSAEG 118
Query: 399 GRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQD--QSSSRDHRDDREPRDGR 456
G+H + + R HERR KR RE+ + RE+E+ + +R+H R R
Sbjct: 119 GKHARVKEKE---REHERR-----KRHREEQDKARREWERQKRREMAREH-----SRRER 165
Query: 457 DRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH 516
DR + + + RE + ++ RE ++ R +E R R++R AH T
Sbjct: 166 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH-------HRTM 218
Query: 517 RKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSR 576
R++ + ++ + R+ R R E+ + R ++ ++M R + +L +
Sbjct: 219 REDYSDKVKASHWSRSPPRPPRERFEL-----GDGRKPVKEEKM-EERDLLSDLQDISDS 272
Query: 577 GSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRE 636
+ S +S S+ S + S E + E + + +S E E + +
Sbjct: 273 ERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 326
Query: 637 RDQRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDRERERD 686
+ S + +E+ DE RE E + V + R +R E E +
Sbjct: 327 NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 377
Score = 72.0 bits (175), Expect = 4e-12
Identities = 81/414 (19%), Positives = 166/414 (40%), Gaps = 67/414 (16%)
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE--- 802
EK+ + + E +E++R +E+E + E +R + D +R+ +RD ++ + RD R E
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-DRDSKRDSLEEGELRDHRMEITI 62
Query: 803 -----KREEIREDRNPRDGH-----DERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYN 852
+RE+ EDR D ++ S+K + R+ +R R HS + +
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHA 122
Query: 853 SGDDKNEKHRLLSQVVRPQES----------RSLSPSHLTEDRQGRWK-EEDRKPERKES 901
+K +H + Q+ R ++ H +R + E R+ ERK
Sbjct: 123 RVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMR 182
Query: 902 SRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAK 961
++ E++E KE+ +++R++ E +++ HH++ + SD+ + ++
Sbjct: 183 EQQKEQREQKERERRAEERRKEREA-------RREVSAHHRTMREDYSDKVKASHWSRSP 235
Query: 962 IQ-----------KKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS 1010
+ +KP+K++K ++ + D Q S + + + +
Sbjct: 236 PRPPRERFELGDGRKPVKEEKMEERDL--------LSDLQDISDSERKTSSAESSSAESG 287
Query: 1011 KGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDE 1070
G + +EE ++ + + +EE E G N Q E+ + + S++
Sbjct: 288 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSED 347
Query: 1071 D----------VP------DRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVA 1108
+ VP D E EAE TP S+ +P P ++
Sbjct: 348 EERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 401
Score = 62.4 bits (150), Expect = 3e-09
Identities = 75/301 (24%), Positives = 123/301 (40%), Gaps = 48/301 (15%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTK----SLEITGERKSR 1250
N R S R +DS Q RK +H ++ K K S G + +R
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHAR 123
Query: 1251 IDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHD 1308
+ + +R R + QD +RR R+ +R S RDRL+ ER R
Sbjct: 124 VKEKEREHERRKRHREEQDK----ARREWERQKRREMAREHSRRERDRLEQLERKRERER 179
Query: 1309 RERERERRDTRQREWDRDADKDWPRNRDRDRLRE-------------------------- 1342
+ RE+++ Q+E +R A++ R ++R+ RE
Sbjct: 180 KMREQQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 236
Query: 1343 ---RERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEG 1396
RER D R+ + E+ ER L+SD + + + ESS ES E + E
Sbjct: 237 RPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEE 296
Query: 1397 EHERDLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHS 1453
E E + E STS +S ++E +++ + EE ++ +E E +DE + ++ H
Sbjct: 297 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 356
Query: 1454 L 1454
L
Sbjct: 357 L 357
Score = 56.6 bits (135), Expect = 2e-07
Identities = 85/423 (20%), Positives = 159/423 (37%), Gaps = 56/423 (13%)
Query: 85 LRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEW 144
L+E+ + K Q+ E ++ + R G R+ ++IT +P E+++E
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHR-MEITIRNSPYRREDSMED 75
Query: 145 ETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRS 204
DDS L+++ +Q ++E K+ EKR+E + S E
Sbjct: 76 RGEEDDS------------LAIKPPQQMSRKE--KVHHRKDEKRKEKRRHRSHSAE---- 117
Query: 205 KLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTP 264
K + K + K+ R+ D+ R Q +++ R
Sbjct: 118 ----------GGKHARVKEKEREHERRKRHREEQ-------DKARREWERQKRREMAREH 160
Query: 265 SPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHH 324
S + L +K + + K++++ +E+ R+ K+R R E +R++R+ R S HH
Sbjct: 161 SRRERDRLE-QLERKRERERKMREQQKEQ-REQKERERRAEERRKEREARREVSA---HH 215
Query: 325 SPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPS-HSLSSPQ 383
+ R S S R P P R+R ++ + +S +
Sbjct: 216 RTM--REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSE 273
Query: 384 RKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSS 443
RK S S G + E + E E+ + E++ EE E E++ S+
Sbjct: 274 RKTSSAESSSAESGSGSEEEE------EEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 327
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRE-----LRDSRDMRDSREMRDYSRDTKESRDPRDS 498
+ ++ + + + D E + +SR RDS E + + E P+ S
Sbjct: 328 SEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG-TPQSS 386
Query: 499 RST 501
T
Sbjct: 387 ALT 389
Score = 56.6 bits (135), Expect = 2e-07
Identities = 67/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND-SAH 1215
H + R R+E++E + RK +Q++ R R+ + R + SAH
Sbjct: 160 HSRRERDRLEQLERKR-----ERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214
Query: 1216 RSG--DDQSGRKRVLH-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRS 1272
+D S + + H S S R + E+ G+ + + + K E R SD QD S
Sbjct: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFEL-GDGRKPVKEEKMEE--RDLLSDLQDI-S 270
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWP 1332
S R++S S SGS + +E + E + E + E + + +++
Sbjct: 271 DSERKTSSAESSSAESGSGSEE-----EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 325
Query: 1333 RNRDRDRLRERERERERDKRRDLDRERER--LISDSVERDRDRDRDRTFESSQIESVKRC 1390
N + + E E + D +RE E L+ DRD E E +
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 385
Query: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAG 1442
A EG++ D + S L K+ + K L ++QG + + +E G
Sbjct: 386 SALTEGDYVPDSPALSPIEL---KQELPKYLPALQGCRSVEEFQCLNRIEEG 434
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 228 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 287
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 288 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 340
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 341 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 392
Score = 40.4 bits (93), Expect = 0.014
Identities = 74/391 (18%), Positives = 130/391 (33%), Gaps = 70/391 (17%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEES----SSPVRKESSRGRHREKEDIKIT 130
R SP R + +R + PQ+ + +E RKE R R E K
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK-- 120
Query: 131 KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190
R E E E+ + +R++ D ++ + EM R+ +RE +LEQ ++ E
Sbjct: 121 HARVKEKEREHERRKRHREEQDKA--RREWERQKRREMAREHSRRERDRLEQLERKRERE 178
Query: 191 IIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRN 250
K+ ++ K +R++ + + R+ SA + +
Sbjct: 179 -------------RKMREQQKEQREQKERERRAEERRKEREAR-REVSAHHRTMREDY-- 222
Query: 251 SKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREK 310
+ K + SPP P E LG K ++E+ + +D D + +
Sbjct: 223 ---SDKVKASHWSRSPPRPPRERFELGDGRKP-------VKEEKMEERDLLSDLQ---DI 269
Query: 311 RDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRS 370
D R TS A SSS++SGS + +
Sbjct: 270 SDSERKTSSA-----------ESSSAESGSGSEEEEEEEEEEE----------------- 301
Query: 371 ASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDS 430
+S + ++ E G + E + QS + E +R+ E
Sbjct: 302 -----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 356
Query: 431 REEREYEQDQSSSRDHRDDREPRDGRDRRDA 461
E D+ S + E +G + A
Sbjct: 357 LVVPESRFDRDSGESEEAEEEVGEGTPQSSA 387
Score = 34.7 bits (78), Expect = 0.74
Identities = 69/433 (15%), Positives = 153/433 (35%), Gaps = 64/433 (14%)
Query: 854 GDDKNE-KHRLLSQVVRPQESRS----------LSPSHLTEDRQGRWKEEDRKPERKESS 902
GD+K+ K + L ++++ ++ R L S + ++ +E + + R E +
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEIT 61
Query: 903 RRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR---------AH 953
R ++ + ++ + I +M ++ + H + E R+ R H
Sbjct: 62 IRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKH 121
Query: 954 DENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGD 1013
K+K + ++ + ++E D + E + S ++ + + +E+KR++ +
Sbjct: 122 ARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 181
Query: 1014 SDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVP 1073
+ E+ Q+ +++R + ++KE A
Sbjct: 182 REQQKEQREQKERERRA------------------------EERRKEREA---------- 207
Query: 1074 DRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTS 1133
R EV+ T + S PP PP + S
Sbjct: 208 -RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS-D 265
Query: 1134 AITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLG 1193
IS S T++ ++ A S + E+ E T E+++ + +++ G
Sbjct: 266 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 325
Query: 1194 SNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQ 1253
SN S S S S ++++ V+ DR+ +GE + ++
Sbjct: 326 SNSEEASEQSAEEVSEEEMSEDEERENEN-HLLVVPESRFDRD-------SGESEEAEEE 377
Query: 1254 LKRGEPSRSTSSD 1266
+ G P S ++
Sbjct: 378 VGEGTPQSSALTE 390
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 122 bits (307), Expect = 2e-27
Identities = 99/348 (28%), Positives = 163/348 (46%), Gaps = 44/348 (12%)
Query: 610 ERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQ-GRNDELERDERREERRVDRV 668
+ D+RD RDS E + RD+R +SP R + D E D+ + ++
Sbjct: 3 QSDDRDSKRDSL-----EEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQM 57
Query: 669 DDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERD 728
R E+ R E+ ++++ R +E+ER+ ER K E+++AR RE ER + R+
Sbjct: 58 S--RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKAR-----REWERQKRRE 110
Query: 729 RDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQR 788
R+H R RER+R E++RERER+ RE+++E+ ++ERER RA ER KERE
Sbjct: 111 MAREHSR-RERDRLEQLERKRERERKMREQQKEQREQKERER-----RAEERRKERE--- 161
Query: 789 DWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDS 848
+RE R R+ + ++ + S SP + P+ R E
Sbjct: 162 -------------ARREVSAHHRTMREDYSDKVKASHW----SRSPPRPPRERFELGDGR 204
Query: 849 DAYNSGDDKNEKHRLLSQVVRPQESR---SLSPSHLTEDRQGRWKEEDRKPERKESSRRY 905
++K E+ LLS + +S S + S E G +EE+ + E +E
Sbjct: 205 KPVK--EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
Query: 906 EEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
EE E +E+ +++ + E+S A+++ SED E + H
Sbjct: 263 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 310
Score = 86.7 bits (213), Expect = 2e-16
Identities = 92/409 (22%), Positives = 154/409 (37%), Gaps = 73/409 (17%)
Query: 572 EKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDR 631
E+G +I +S DS E R E D + + +R R E+ +
Sbjct: 15 EEGELRDHRMEITIRNSPYRREDSMEDRGE--EDDSLAIKPPQQMSRKEKVHHRKDEKRK 72
Query: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERER 691
R + + R+ E + RRE R R + R+ RERDR + +R+RER
Sbjct: 73 EKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRER 132
Query: 692 ERE-RERDREREKERELER---ERARERERERE--------------------------- 720
ER+ RE+ +E+ +++E ER ER +ERE RE
Sbjct: 133 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 192
Query: 721 --------------------KERDRERDRDRDHDRERERE------------RERDREKE 748
+ERD D D ER+ E + E+E
Sbjct: 193 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 252
Query: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIR 808
E E E E E E E E E E + + + + +++ D+ RE +
Sbjct: 253 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 312
Query: 809 EDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVV 868
R D +S++ G +P+ S ++ PDS A + + K E + L +
Sbjct: 313 VVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPAL- 371
Query: 869 RPQESRSLSP----SHLTEDRQG-RWKEEDRKPERKESSRRYEEQELKE 912
Q RS+ + + E G ++ +D+K + + +R + ++ KE
Sbjct: 372 --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKE 418
Score = 85.5 bits (210), Expect = 4e-16
Identities = 78/356 (21%), Positives = 146/356 (41%), Gaps = 34/356 (9%)
Query: 570 LPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGER 629
+ + R S+ ++ + + S Y D +R D + ++ +
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 630 DRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERD--- 686
++ +R+ ++R + R E ER+ R +R + D R E R++ RE R+
Sbjct: 61 EKVHHRKDEKRKE---KKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSR 117
Query: 687 RERERERERERDRERE-KERELERERARERERER---EKERDRERDRDRDHDRERERERE 742
RER+R + ER RERE K RE ++E+ ++ERER E+ ++RE R+ RE
Sbjct: 118 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 177
Query: 743 RDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE 802
D+ K R RER + + + E+ ERD + Q D +R+
Sbjct: 178 SDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ------DISDSERKT 231
Query: 803 KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
E + +E + ++ EGS S + E + + ++ ++ +E
Sbjct: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASE--- 288
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRK----PERKESSRRYEEQELKEKV 914
Q + +S ++ED + +E + PE + E +E +E+V
Sbjct: 289 --------QSAEEVSEEEMSEDEE---RENENHLLVVPESRFDRDSGESEEAEEEV 333
Score = 84.7 bits (208), Expect = 6e-16
Identities = 86/342 (25%), Positives = 128/342 (37%), Gaps = 30/342 (8%)
Query: 457 DRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH 516
DR RD+ + ELRD R R D+ E R D R+ + H
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHH 65
Query: 517 RKEDTYPEES----RSYGRNHLREESSRTE---IRNESRNESRSEIRNDRMGRSRGRVPE 569
RK++ E+ + R H R + R E R E + R E+ + R R R+ +
Sbjct: 66 RKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ 125
Query: 570 LPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPE--RDNRDQARDSSFERRHG 627
L K R + + + ER+R E R R+ R+ S R
Sbjct: 126 LERKRER------------ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 173
Query: 628 ERDRRDNRERDQRPSSPIRHQGRNDEL------ERDERREERRVDRVDDRRDERARERDR 681
D D + SP R EL ++E+ EER D + D +D ER
Sbjct: 174 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER--DLLSDLQDISDSERKT 231
Query: 682 ERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERER 741
E E + E E+E E E + E E E E+E + E + + + E+
Sbjct: 232 SSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSA 291
Query: 742 ERDREKEREREREERERERERERERERERERERERARERDKE 783
E E+E E EERE E E +R+ + E ++E
Sbjct: 292 EEVSEEEMS-EDEERENENHLLVVPESRFDRDSGESEEAEEE 332
Score = 77.4 bits (189), Expect = 1e-13
Identities = 73/277 (26%), Positives = 123/277 (44%), Gaps = 23/277 (8%)
Query: 1230 SGSRDRE-KTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESD----R 1284
S S DR+ K SLE R R++ R P R S S P
Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKE 61
Query: 1285 QVHSRSGSFDSRD---RLQERDRYEHDRERERERRDTRQREWDRDADKDWPR---NRDRD 1338
+VH R R++E++R R+R RE +D +REW+R ++ R R+RD
Sbjct: 62 KVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERD 121
Query: 1339 RLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEH 1398
RL + ER+RER+++ RE+++ + ER+R R +R E V + ++
Sbjct: 122 RLEQLERKRERERKM---REQQKEQREQKERER-RAEERRKEREARREVSAHHRTMREDY 177
Query: 1399 ERDLEST--SRDSLALDKERMDKDLGSVQGFEETNKSERTESL----EAGDDESKLDDAH 1452
++++ SR +ER +LG + + K E + L + D E K A
Sbjct: 178 SDKVKASHWSRSPPRPPRERF--ELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAE 235
Query: 1453 SLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
S + +G G E ++E +E G + ++++EE+
Sbjct: 236 SSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 272
Score = 75.9 bits (185), Expect = 3e-13
Identities = 80/358 (22%), Positives = 126/358 (35%), Gaps = 36/358 (10%)
Query: 395 MREKGRHDHERTS-QSHDRRHERREDT-RGKRDREKDSREEREYEQDQSSSRDHRDDREP 452
M + D +R S + + R R E T R R +DS E+R E D + + P
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIK-------P 53
Query: 453 RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREG 512
R++ R + ++ + R + R++ R R RE
Sbjct: 54 PQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRK------------------RHREE 95
Query: 513 RDTHRKEDTYPEESRSYGRNHLREESSR---TEIRNESRNESRSEIRNDRMGRSRGRVPE 569
+D R+E ++ R R H R E R E + E + R + + R + R R E
Sbjct: 96 QDKARRE-WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAE 154
Query: 570 LPEKGSRGSRGSQIDSHSSNSNYHDS-----WETRSSYPERDRYPERDNRDQARDSSFER 624
K R + +Y D W P R+R+ D R ++ E
Sbjct: 155 ERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE 214
Query: 625 RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERE 684
R D +D + +++ SS + +E EE + +E E + E E
Sbjct: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 274
Query: 685 RDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERE 742
+ E E ++ E+ E E ERE E E DRD E E E
Sbjct: 275 EEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 332
Score = 72.4 bits (176), Expect = 3e-12
Identities = 70/305 (22%), Positives = 127/305 (41%), Gaps = 31/305 (10%)
Query: 388 PPRHRSPMREKGRH--DHERTSQSHDRRHER-REDTRGKRDREKDSREEREYEQD--QSS 442
PP+ S +EK H D +R + H R E+ RE R KR RE+ + RE+E+ +
Sbjct: 53 PPQQMS-RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREM 111
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
+R+H R RDR + + + RE + ++ RE ++ R +E R R++R
Sbjct: 112 AREH-----SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 166
Query: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
AH T R++ + ++ + R+ R R E+ + R ++ ++M
Sbjct: 167 SAH-------HRTMREDYSDKVKASHWSRSPPRPPRERFEL-----GDGRKPVKEEKM-E 213
Query: 563 SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSF 622
R + +L + + S +S S+ S + S E + E + + +S
Sbjct: 214 ERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGSTSEESEE 267
Query: 623 ERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDR 681
E E + + + S + +E+ DE RE E + V + R +R
Sbjct: 268 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 327
Query: 682 ERERD 686
E E +
Sbjct: 328 EAEEE 332
Score = 60.1 bits (144), Expect = 2e-08
Identities = 73/297 (24%), Positives = 121/297 (40%), Gaps = 51/297 (17%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQL 1254
N R S R +DS Q RK +H ++ K K + +R+ +
Sbjct: 30 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-------KHARVKEK 82
Query: 1255 KRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHDRERE 1312
+R R + QD +RR R+ +R S RDRL+ ER R + RE
Sbjct: 83 EREHERRKRHREEQDK----ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 138
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRE-----------------------------R 1343
+++ Q+E +R A++ R ++R+ RE R
Sbjct: 139 QQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 195
Query: 1344 ERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHER 1400
ER D R+ + E+ ER L+SD + + + ESS ES E + E E E
Sbjct: 196 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 255
Query: 1401 DLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHSL 1454
+ E STS +S ++E +++ + EE ++ +E E +DE + ++ H L
Sbjct: 256 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 312
Score = 57.4 bits (137), Expect = 1e-07
Identities = 69/366 (18%), Positives = 142/366 (38%), Gaps = 55/366 (15%)
Query: 783 ERERQRDWEDKDKGRDDRRE--------KREEIREDRNPRDGHDERKSKKRYRNEGSPSP 834
+R+ +RD ++ + RD R E +RE+ EDR D K ++ +
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHH 65
Query: 835 RQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRP----QESRSLSPSHLTEDRQGRWK 890
R+ KR+ + ++ ++HR R Q+ R ++ H +R +
Sbjct: 66 RKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQ 125
Query: 891 -EEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETS 949
E R+ ERK ++ E++E KE+ +++R++ E +++ HH++ + S
Sbjct: 126 LERKRERERKMREQQKEQREQKERERRAEERRKEREA-------RREVSAHHRTMREDYS 178
Query: 950 DRAHDENKKKAKIQ-----------KKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQ 998
D+ + ++ + +KP+K++K ++ + D Q S + +
Sbjct: 179 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDL--------LSDLQDISDSERK 230
Query: 999 KKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQK 1058
+ + G + +EE ++ + + +EE E G N Q
Sbjct: 231 TSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQS 290
Query: 1059 KEDTAFSDWSDED----------VP------DRTEVTEAEHTATATTPGSTPSPLSSLLP 1102
E+ + + S+++ VP D E EAE TP S+ +P
Sbjct: 291 AEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVP 350
Query: 1103 PPPPVA 1108
P ++
Sbjct: 351 DSPALS 356
Score = 56.6 bits (135), Expect = 2e-07
Identities = 67/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND-SAH 1215
H + R R+E++E + RK +Q++ R R+ + R + SAH
Sbjct: 115 HSRRERDRLEQLERKR-----ERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169
Query: 1216 RSG--DDQSGRKRVLH-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRS 1272
+D S + + H S S R + E+ G+ + + + K E R SD QD S
Sbjct: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFEL-GDGRKPVKEEKMEE--RDLLSDLQDI-S 225
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWP 1332
S R++S S SGS + +E + E + E + E + + +++
Sbjct: 226 DSERKTSSAESSSAESGSGSEE-----EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 280
Query: 1333 RNRDRDRLRERERERERDKRRDLDRERER--LISDSVERDRDRDRDRTFESSQIESVKRC 1390
N + + E E + D +RE E L+ DRD E E +
Sbjct: 281 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 340
Query: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAG 1442
A EG++ D + S L K+ + K L ++QG + + +E G
Sbjct: 341 SALTEGDYVPDSPALSPIEL---KQELPKYLPALQGCRSVEEFQCLNRIEEG 389
Score = 51.6 bits (122), Expect = 6e-06
Identities = 74/358 (20%), Positives = 134/358 (37%), Gaps = 24/358 (6%)
Query: 151 SDNGDINYDYVHELSLEMKRQKIQ-RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPS 209
SD+ D D + E L R +I R +++ME R E + P S+
Sbjct: 4 SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63
Query: 210 PSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPP 269
+ + K+ + K + RK D+ R Q +++ R S
Sbjct: 64 HHRKDEKRKEKKHARVKEKEREHERRKRHREEQ---DKARREWERQKRREMAREHSRRER 120
Query: 270 IPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISS 329
+ L +K + + K++++ +E+ R+ K+R R E +R++R+ R S HH +
Sbjct: 121 DRLE-QLERKRERERKMREQQKEQ-REQKERERRAEERRKEREARREVSA---HHRTM-- 173
Query: 330 RHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPS-HSLSSPQRKQSP 388
R S S R P P R+R ++ + +S +RK S
Sbjct: 174 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS 233
Query: 389 PRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRD 448
S G + E + E E+ + E++ EE E E++ S+ +
Sbjct: 234 AESSSAESGSGSEEEE------EEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEAS 287
Query: 449 DREPRDGRDRRDARDTRDRRE-----LRDSRDMRDSREMRDYSRDTKESRDPRDSRST 501
++ + + + D E + +SR RDS E + + E P+ S T
Sbjct: 288 EQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG-TPQSSALT 344
Score = 46.2 bits (108), Expect = 2e-04
Identities = 60/309 (19%), Positives = 121/309 (39%), Gaps = 34/309 (11%)
Query: 798 DDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDK 857
DDR KR+ + E + R + SP R+ R DS A
Sbjct: 5 DDRDSKRDSLEEG-------ELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQM 57
Query: 858 NEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSV 917
+ K ++ R E R ++++ + R E ++ +RR E++ + +++
Sbjct: 58 SRKEKVHH---RKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 114
Query: 918 DKQREQTEILESSRMRAQD-IIGHHQSEDRETSDRAH--DENKKKAKIQK------KPIK 968
+RE+ + + R R ++ + Q E RE +R +E +K+ + ++ + ++
Sbjct: 115 HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 174
Query: 969 KKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS--KGDSDISDEEAAQQSK 1026
+ D V + + F G+K EK ++ DISD E S
Sbjct: 175 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSA 234
Query: 1027 KKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTAT 1086
+ + + +EE E+ +++E+ + S+ S+E+ + E E E T +
Sbjct: 235 ESSSAESGSGSEEEE-----------EEEEEEEEEGSTSEESEEE--EEEEEEEEEETGS 281
Query: 1087 ATTPGSTPS 1095
+ S S
Sbjct: 282 NSEEASEQS 290
Score = 42.7 bits (99), Expect = 0.003
Identities = 71/388 (18%), Positives = 131/388 (33%), Gaps = 60/388 (15%)
Query: 84 DLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVE 143
D R+ ++ ++ + + +SP R+E S E++D K S +E V
Sbjct: 5 DDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVH 64
Query: 144 WETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVR 203
+R D + + V E E +R+K RE EQ+ + E ++E++ E R
Sbjct: 65 ---HRKDEKRKEKKHARVKEKEREHERRKRHRE----EQDKARREWERQKRREMAREHSR 117
Query: 204 SKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKT---------- 253
+ L + + ++ + +K+R+ A + R +
Sbjct: 118 RERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDY 177
Query: 254 NQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDK 313
+ K + SPP P E LG K ++E+ + +D D + + D
Sbjct: 178 SDKVKASHWSRSPPRPPRERFELGDGRKP-------VKEEKMEERDLLSDLQ---DISDS 227
Query: 314 PRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASP 373
R TS A SSS++SGS + +
Sbjct: 228 ERKTSSA-----------ESSSAESGSGSEEEEEEEEEEE-------------------- 256
Query: 374 YPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREE 433
+S + ++ E G + E + QS + E +R+ E
Sbjct: 257 --EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVV 314
Query: 434 REYEQDQSSSRDHRDDREPRDGRDRRDA 461
E D+ S + E +G + A
Sbjct: 315 PESRFDRDSGESEEAEEEVGEGTPQSSA 342
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 183 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 242
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 243 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 295
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 296 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 347
Score = 37.0 bits (84), Expect = 0.15
Identities = 62/391 (15%), Positives = 140/391 (35%), Gaps = 46/391 (11%)
Query: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
+S S + ++ +E + + R E + R ++ + ++ + I +M +
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 936 DIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPK 995
+ + H + E R+ ++ H K+K + ++ + ++E D + E + S +
Sbjct: 61 EKVHHRKDEKRK--EKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 118
Query: 996 KGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILED 1055
+ + + +E+KR++ + + E+ Q+ +++R +
Sbjct: 119 ERDRLEQLERKRERERKMREQQKEQREQKERERRA------------------------E 154
Query: 1056 SQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVATATATTV 1115
++KE A R EV+ T + S PP PP
Sbjct: 155 ERRKEREA-----------RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDG 203
Query: 1116 PATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTI 1175
+ S IS S T++ ++ A S + E+ E T
Sbjct: 204 RKPVKEEKMEERDLLS-DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTS 262
Query: 1176 EDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDR 1235
E+++ + +++ GSN S S S S ++++ V+ DR
Sbjct: 263 EESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN-HLLVVPESRFDR 321
Query: 1236 EKTKSLEITGERKSRIDQLKRGEPSRSTSSD 1266
+ +GE + +++ G P S ++
Sbjct: 322 D-------SGESEEAEEEVGEGTPQSSALTE 345
Score = 35.0 bits (79), Expect = 0.57
Identities = 39/243 (16%), Positives = 98/243 (40%), Gaps = 8/243 (3%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRK-ESSRGRHREKEDIKITKER 133
+R E RE + KR+++ E +R + RK E R ++++ + KER
Sbjct: 90 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 149
Query: 134 TPESEEENVEWETNRD-DSDNGDINYDYVHELSL---EMKRQKIQRELMKLEQENMEKRE 189
+EE E E R+ + + + DY ++ + RE +L +E
Sbjct: 150 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 209
Query: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQR 249
E + ++++ ++ S + S S + S + +++ + +S +++
Sbjct: 210 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 269
Query: 250 NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDR---IEEKTRDGKDRGRDFER 306
+ + ++ G + E+++ + +++ + + + ++R +D G E
Sbjct: 270 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 329
Query: 307 QRE 309
+ E
Sbjct: 330 EEE 332
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 122 bits (307), Expect = 2e-27
Identities = 106/386 (27%), Positives = 193/386 (50%), Gaps = 38/386 (9%)
Query: 520 DTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE--KGSRG 577
D + S S N+ ++ S+ NE++ E+ E+ N + S ++P P K G
Sbjct: 336 DDDEQGSNSPKENNSEDQGSKASENNENKKET-DEVSNTK---SSSQIPAQPSVAKVPYG 391
Query: 578 SRGSQIDSHSSNSNYHDSWETRSSY---PERDRYPERDNRDQARDSSFERRHGERDRRDN 634
S ++S+ + + P+R P R ++ + + RR
Sbjct: 392 KGPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRR-- 449
Query: 635 RERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERE 694
R Q S + R E + R EE+R ++ +R E+ E+ E RE
Sbjct: 450 --RQQSEISAAVERARKRREEEERRMEEQRKAACAEKL-KRLDEKLGILEKQPSPEEIRE 506
Query: 695 RERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE 754
RER++ERE+E+ELE+E+ E+ERE+E+E+DRER ++++ + E+E+E++R+ EKER++E+
Sbjct: 507 REREKEREREKELEKEQ--EQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEK- 563
Query: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814
E+E ER++E+E+E ++ +E+E+ E +KERE+ E+K + R+ E E +E N
Sbjct: 564 EKELERQKEKEKELQKMKEQEKECELEKEREK---LEEKIEPREPNLEPMVEKQESENSC 620
Query: 815 DGHDE----RKSKKRYRNEGSPSPRQS-PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVR 869
+ +E R+ R E +P ++ P+ + P A SG K + L + R
Sbjct: 621 NKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRP---AVLSGYFKQFQKSLPPRFQR 677
Query: 870 PQESRSLSPSHLTEDRQGRWKEEDRK 895
QE + +Q +W+++ ++
Sbjct: 678 QQE----------QMKQQQWQQQQQQ 693
Score = 111 bits (277), Expect = 6e-24
Identities = 82/331 (24%), Positives = 164/331 (49%), Gaps = 31/331 (9%)
Query: 509 DREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEI------------R 556
D +G ++ ++ ++ + S++ N ++E+ S +S S+I +
Sbjct: 338 DEQGSNSPKENNSEDQGSKASENNENKKETDEV-----SNTKSSSQIPAQPSVAKVPYGK 392
Query: 557 NDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQ 616
+ RG LP ++ + + ++ + D ++ R Q
Sbjct: 393 GPSFNQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQ 452
Query: 617 ARDSS-FERRHGERDRRDNRERDQRPSSPIRHQGRNDE----LERDERREERRVDRVDDR 671
+ S+ ER R+ + R +QR ++ R DE LE+ EE R +R
Sbjct: 453 SEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRER---ER 509
Query: 672 RDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDR 731
ER RE++ E+E+++ERE+ERE++R+R++EKE+ELE+E+ ++RE E+E+++++E++ +R
Sbjct: 510 EKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELER 569
Query: 732 DHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWE 791
++E+E ++ +++EKE E E+ ERE+ E+ RE E E+ ++ E ++ E
Sbjct: 570 QKEKEKELQKMKEQEKECELEK-EREKLEEKIEPREPNLEPMVEK---QESENSCNKEEE 625
Query: 792 DKDKGRDDRREKRE--EIREDRNPRDGHDER 820
+D R ++E + + P G R
Sbjct: 626 PVFTRQDSNRSEKEATPVVHETEPESGSQPR 656
Score = 79.0 bits (193), Expect = 3e-14
Identities = 211/1067 (19%), Positives = 381/1067 (35%), Gaps = 171/1067 (16%)
Query: 159 DYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKS 218
D++ E S ++ + R + + + + + + + + + S +S S
Sbjct: 861 DFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSAPQEERISAVESQPS 920
Query: 219 PKRKSSPKSSSASKKDRKTSA-------VSSPLLDQQRNSKTNQSK-KKGPRTPSPPPPI 270
KR S S+ K D + S V+S +D + + + K KK S P
Sbjct: 921 RKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEKPKKEGFIRSSEGPK 980
Query: 271 PEDIALGK---KYKEKYKVKDRIEEKTRDGKDRG-------RDFERQREKRDKPRSTSPA 320
PE + K ++ + R E R + G RD + +RE+R K + A
Sbjct: 981 PEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKEEREQR-KEKEGEKA 1039
Query: 321 GQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLS 380
+ + + + + P P + P+P +++ PP++ A +PS +
Sbjct: 1040 EKVTEKVVVKPEKTEKKD------LPPPPPPPQPPAPIQPQSVPPPIQPEAEKFPSTETA 1093
Query: 381 SPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQ 440
+ +K S + P+ E ++ +++ + ++ EK ++ E+ +
Sbjct: 1094 TLAQKPSQDTEK-PLEPVSTVQVEPAVKTVNQQTMAAPVVKEEKQPEKVISKDLVIERPR 1152
Query: 441 SSSRDHRDDREPRDGRDR-RDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSR 499
SR R ++AR+ RD + R R SR R
Sbjct: 1153 PDSRPAVKKESTLPPRTYWKEARE----------RDWFPDQGYRGRGRGEYYSR----GR 1198
Query: 500 STRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRT-EIRNESRNESRSEIRND 558
S R ++ R R GR R YP+ Y N R E + +R +E+RSE +
Sbjct: 1199 SYRGSYGGRGRGGRGHTRD---YPQ----YRDNKPRAEHIPSGPLRQREESETRSESSDF 1251
Query: 559 RMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQAR 618
+ R R ++GS S+I +S+ DS ++ P+R+ PE +
Sbjct: 1252 EVVPKRRR-----QRGSETDTDSEIHESASDK---DSL-SKGKLPKREERPENKKPVKPH 1302
Query: 619 DSSFERRHGERDRR----------DNRERDQRPSSPIRHQGRNDELERDERREERRVDRV 668
S H D R D + P +GR R R R R
Sbjct: 1303 SSFKPDNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRP 1362
Query: 669 DDRRDERARERDRE-RERDRERERERERERDREREKERELERERAREREREREKERDRER 727
R R RD + R E + + E R E+ + ++ R + ER+ + RER
Sbjct: 1363 STLR--RPAYRDNQWNPRQSEVPKPEDGEPPRRHEQFIPIAADK-RPPKFERKFDPARER 1419
Query: 728 DRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR--------- 778
R + R +++ + RERE + E +E
Sbjct: 1420 PRRQRPTRPPRQDKPPRFRRLREREAASKSNEVVAVPTNGTVNNVAQEPVNTLGDISGNK 1479
Query: 779 -----ERDKERERQRDWEDKDKGRD--DRREKREEIREDRNPRD----GHDERKSKKRY- 826
++ + +WE + D +RRE+ E+ D N + G + K+
Sbjct: 1480 TPDLSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIA 1539
Query: 827 -RNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDR 885
R+ S P RR + P N +NE+ RS PS
Sbjct: 1540 KRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNER-------------RSGPPS------ 1580
Query: 886 QGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDII--GHHQS 943
+S +R + + VD ++ S Q+ + G Q
Sbjct: 1581 --------------KSGKRGPFDDQPAGTTGVD-------LINGSSAHHQEGVPNGTGQK 1619
Query: 944 EDRETSDRAHDENKKKAKIQKKPIKKKKEDDVG-------IERGNIETTSEDGQV----- 991
++++ + ++ K K K+ + + D+ I+ T ED Q
Sbjct: 1620 NSKDSTGKKREDPKPGPKKPKEKVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDD 1679
Query: 992 ----FSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCN 1047
KK QK+ E++RKK + + +++ A + + + + PP K++ +
Sbjct: 1680 GFTEVVSKKQQKRLQDEERRKKEEQVIQVWNKKNANEKGRSQTSKLPPRFAKKQATGI-- 1737
Query: 1048 GKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPP--- 1104
Q + + + +P T + T+ TP P S+ P P
Sbjct: 1738 --------QQAQSSASVPPLASAPLPPSTSASVPASTSAPLPATLTPVPASTSAPVPAST 1789
Query: 1105 -PPVATATATTVPAT-LAATTAAAATS----FSTSAITISTSATPTN 1145
PV +T+ VPA+ LA +A+A+ S STSA I++S+ P +
Sbjct: 1790 LAPVLASTSAPVPASPLAPVSASASVSASVPASTSAAAITSSSAPAS 1836
Score = 75.9 bits (185), Expect = 3e-13
Identities = 66/347 (19%), Positives = 152/347 (43%), Gaps = 16/347 (4%)
Query: 570 LPEKGSRGSRGSQID-SHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGE 628
L + G G+Q++ ++ N+ D E S+ P+ + ++ ++ + + +
Sbjct: 311 LDAEADEGWAGAQMEVDYTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEV 370
Query: 629 RDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDR- 687
+ + + + +PS G+ + ER + ++ DR+ R
Sbjct: 371 SNTKSSSQIPAQPSVAKVPYGKGPSFNQ-ERGTSSHLPPPPKLLAQQHPPPDRQAVPGRP 429
Query: 688 ----ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERER 743
+++ + + ++ + ++ E A ER R+R +E +R + E+ +
Sbjct: 430 GPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRME-------EQRKAACA 482
Query: 744 DREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREK 803
++ K + + E++ E RERERE+ERER +E +KE+E++R+ ++++K R+ ++EK
Sbjct: 483 EKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE-KEREKDRERQQEK 541
Query: 804 REEI-REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHR 862
+E+ +E R+ ERK +K E + ++ +E + + + EK
Sbjct: 542 EKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIE 601
Query: 863 LLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQE 909
+ P + S + ++ + + +D KE++ E E
Sbjct: 602 PREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETE 648
Score = 70.1 bits (170), Expect = 2e-11
Identities = 178/921 (19%), Positives = 301/921 (32%), Gaps = 118/921 (12%)
Query: 66 RGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKE 125
R K + E+ RER + K ++++ E +K+ E KE R +EKE
Sbjct: 515 REKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKE 574
Query: 126 -DIKITKERTPESEEENVEWETNRDDSDNGDINYD-YVHELSLEMKRQKIQRELMKLEQE 183
+++ KE+ E E E E E + + + N + V + E K + + +
Sbjct: 575 KELQKMKEQEKECELEK-EREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDS 633
Query: 184 NMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSP 243
N ++E + E PE S P P++ +KS P ++ K
Sbjct: 634 NRSEKEATPVVHETEPE---SGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMK----QQQ 686
Query: 244 LLDQQRNSKTNQSKKKGPRTPSPPP-----------PIPEDIALGKKYKEKYKVKDRIEE 292
QQ+ Q+ P + + PP P P+ +A ++ ++
Sbjct: 687 WQQQQQQGVLPQTVPSQPSSSTVPPPPHRPLYQPMQPHPQHLASMGFDPRWLMMQSYMDP 746
Query: 293 KTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRK 352
+ G R D P P P+ R S + S H R
Sbjct: 747 RMMSG----------RPAMDIP-PIHPGMIPPKPLMRRDQMEGSPNSSESFEHIARSARD 795
Query: 353 RTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSP--MREKGRHDHERTSQSH 410
S S R L + PYP + PQ+ +P P +R + D E+ + ++
Sbjct: 796 HAISLSEPRMLW-----GSDPYPH---AEPQQATTPKATEEPEDVRSEAALDQEQITAAY 847
Query: 411 DRRHERREDTRGKRDREKDSREEREYEQDQSSSRD----HRDDREPRDGRDRRDARDTRD 466
H + E K D ++S E + + S D H D + D +
Sbjct: 848 SVEHNQLE-AHPKADFIRESSEAQVQKFLSRSVEDVRPHHTDANNQSACFEAPDQKTLSA 906
Query: 467 RRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDA-------------------HDY 507
+E R S R S + ++ P + RS A +
Sbjct: 907 PQEERISAVESQPSRKRSVSHGSNHTQKPDEQRSEPSAGIPKVTSRCIDSKEPIERPEEK 966
Query: 508 RDREG--RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNE------------------S 547
+EG R + + +S+S R R S+R E N+
Sbjct: 967 PKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPVRRSGPIKKPVLRDMKE 1026
Query: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607
E R E ++ + +V PEK + + PE ++
Sbjct: 1027 EREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQPQSVPPPIQPEAEK 1086
Query: 608 YPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER-----REE 662
+P + A+ S + E+ P S ++ + + + +EE
Sbjct: 1087 FPSTETATLAQKPS-----------QDTEKPLEPVSTVQVEPAVKTVNQQTMAAPVVKEE 1135
Query: 663 RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722
++ ++V + R R R ++ R +E + + R R R
Sbjct: 1136 KQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGRGEYYS 1195
Query: 723 RDRE-------RDR-DRDHDRERERERERDREKEREREREERERERERERERERERE--- 771
R R R R R H R+ + R+ E R+RE R + E
Sbjct: 1196 RGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSDFEVVP 1255
Query: 772 -RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEG 830
R R+R E D + E DKD + KREE E++ P H K R +
Sbjct: 1256 KRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKPDNHVRIDN 1315
Query: 831 ----SPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ 886
P R K + P + G + RP +L +++
Sbjct: 1316 RLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRRPAYRDNQW 1375
Query: 887 GRWKEEDRKPERKESSRRYEE 907
+ E KPE E RR+E+
Sbjct: 1376 NPRQSEVPKPEDGEPPRRHEQ 1396
Score = 64.7 bits (156), Expect = 7e-10
Identities = 54/255 (21%), Positives = 122/255 (47%), Gaps = 16/255 (6%)
Query: 1153 NEDSHRKCHRTRVEKVETPHVTIEDAQHR---KPMDQKRSSSLGSNRSNRSHTSGRLRSP 1209
+ED K K ET V+ + + +P K G + + TS L P
Sbjct: 350 SEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERGTSSHLPPP 409
Query: 1210 SNDSA--HRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDR 1267
A H D Q+ R S+ + + EI +R+ + ++ +
Sbjct: 410 PKLLAQQHPPPDRQAVPGRPGPFPSKQQVADED-EIWKQRRRQQSEISAAVERARKRREE 468
Query: 1268 QDSRSHSSRRSS-PESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRD 1326
++ R R+++ E +++ + G + + +E E ++ERERE+ +++E +R+
Sbjct: 469 EERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE 528
Query: 1327 ADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIES 1386
+++ ++R+R + +E+E E+E++K+R++++ER++ +ER +++++ +++
Sbjct: 529 KERE--KDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEK-------ELQK 579
Query: 1387 VKRCEAKLEGEHERD 1401
+K E + E E ER+
Sbjct: 580 MKEQEKECELEKERE 594
Score = 60.1 bits (144), Expect = 2e-08
Identities = 45/201 (22%), Positives = 100/201 (49%), Gaps = 28/201 (13%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSS-----RRSSPESDRQVH 1287
R ++ S + RK R ++ +R E R + + R ++ SPE R+
Sbjct: 449 RRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRE-- 506
Query: 1288 SRSGSFDSRDRLQERDR-------YEHDRERERERRDTRQREWDRDADKDWPRNRDRDRL 1340
R+R +ER+R E +RE+ERE+ RQ+E +++ +K+ + R+ ++
Sbjct: 507 --------REREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKE 558
Query: 1341 RERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIES------VKRCEAKL 1394
R++E+E+E +++++ ++E +++ E + +++R++ E + V++ E++
Sbjct: 559 RKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESEN 618
Query: 1395 EGEHERDLESTSRDSLALDKE 1415
E + T +DS +KE
Sbjct: 619 SCNKEEEPVFTRQDSNRSEKE 639
Score = 58.9 bits (141), Expect = 4e-08
Identities = 70/345 (20%), Positives = 133/345 (38%), Gaps = 74/345 (21%)
Query: 793 KDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYN 852
K+ +D+ K E E++ D KS + PS + P Y
Sbjct: 346 KENNSEDQGSKASENNENKKETDEVSNTKSSSQI--PAQPSVAKVP------------YG 391
Query: 853 SGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ---GR----------------WKEED 893
G N++ S + P + L+ H DRQ GR WK+
Sbjct: 392 KGPSFNQERGTSSHL--PPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRR 449
Query: 894 R------------KPERKESSRRYEEQE----------LKEKVSSVDKQREQTEILESSR 931
R + R+E RR EEQ L EK+ ++KQ EI E R
Sbjct: 450 RQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIRERER 509
Query: 932 MRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQV 991
+ ++ + E + ++ ++++++ + ++K ++K++E +E+ + ++ +
Sbjct: 510 EKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELE- 568
Query: 992 FSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNG 1051
++ +K+K ++K +++ K + E ++ + R P P+ K+E CN
Sbjct: 569 ---RQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESENSCN---- 621
Query: 1052 ILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSP 1096
K+E+ F+ + E T H T GS P P
Sbjct: 622 ------KEEEPVFT--RQDSNRSEKEATPVVH-ETEPESGSQPRP 657
Score = 54.7 bits (130), Expect = 7e-07
Identities = 176/899 (19%), Positives = 303/899 (33%), Gaps = 140/899 (15%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
RR + ER + +R++ ++R EE E + R EK I + K+ +
Sbjct: 448 RRRQQSEISAAVERARKRREE-----EERRMEEQRKAACAEKLK-RLDEKLGI-LEKQPS 500
Query: 135 PESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKRE-EIII 193
PE E E E R+ + + E E R++ Q + +LE+E ++RE E
Sbjct: 501 PEEIRER-EREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKER 559
Query: 194 KKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKT 253
K+E E+ R K K + K K K K+ K
Sbjct: 560 KQEKEKELERQK-------EKEKELQKMKEQEKECELEKEREKL---------------- 596
Query: 254 NQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDK 313
+K PR P+ P + + + KE+ V R + + + E + E +
Sbjct: 597 --EEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQ 654
Query: 314 PRSTSPAG--------------QHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSY 359
PR +G + + + Q G Q P P P +
Sbjct: 655 PRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTVPPPPH 714
Query: 360 QRTLTPPLRRSASPYPSH--SLSSPQRKQSPPRHRSPMREKGR--------HDHERTSQS 409
+ PL + P+P H S+ R + P GR H +
Sbjct: 715 R-----PLYQPMQPHPQHLASMGFDPRWLMMQSYMDPRMMSGRPAMDIPPIHPGMIPPKP 769
Query: 410 HDRRHERREDTRGKRDREKDSREEREYEQDQSSSR--------DHRDDREPRDGRDRRDA 461
RR + E +R R++ S R H + ++ + +
Sbjct: 770 LMRRDQMEGSPNSSESFEHIARSARDHAISLSEPRMLWGSDPYPHAEPQQATTPKATEEP 829
Query: 462 RDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDT 521
D R L D + + + + D S + R D
Sbjct: 830 EDVRSEAAL-DQEQITAAYSVEHNQLEAHPKADFIRESSEAQVQKFLSRSVEDVRPHHTD 888
Query: 522 YPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRG- 580
+S + + S+ E R + S R+ G + + P+ E+ S S G
Sbjct: 889 ANNQSACFEAPDQKTLSAPQEERISAVESQPSRKRSVSHGSNHTQKPD--EQRSEPSAGI 946
Query: 581 SQIDSHSSNSNYHDSWETRSSYPERD---RYPERDNRDQARDSSFERRHGERDRRDNRE- 636
++ S +S + E P+++ R E ++ S E R G R + RE
Sbjct: 947 PKVTSRCIDSK--EPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREE 1004
Query: 637 ---RDQRPSSPIRHQGRNDELERDERREER---RVDRVDDR---RDERARERD------- 680
R R S PI+ D E E+R+E+ + ++V ++ + E+ ++D
Sbjct: 1005 VNDRPVRRSGPIKKPVLRDMKEEREQRKEKEGEKAEKVTEKVVVKPEKTEKKDLPPPPPP 1064
Query: 681 -----------------RERERDRERE-----RERERERDREREKERELERERARERERE 718
E E+ E ++ ++ ++ E ++ E A + +
Sbjct: 1065 PQPPAPIQPQSVPPPIQPEAEKFPSTETATLAQKPSQDTEKPLEPVSTVQVEPAVKTVNQ 1124
Query: 719 R-------EKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERE 771
+ ++E+ E+ +D ER R R K+ + RER+ + +
Sbjct: 1125 QTMAAPVVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPD-Q 1183
Query: 772 RERERARERDKERERQRDWEDKDKGRDDRREKREEIR-EDRNPRDGHDERKSKKRYRNEG 830
R R R R R +GR R R+ + D PR H R R E
Sbjct: 1184 GYRGRGRGEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEHIP-SGPLRQREES 1242
Query: 831 SPSPRQS-----PKRRR----EHSPDSDAYNSGDDKN--EKHRLLSQVVRPQESRSLSP 878
S PKRRR E DS+ + S DK+ K +L + RP+ + + P
Sbjct: 1243 ETRSESSDFEVVPKRRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKP 1301
Score = 48.5 bits (114), Expect = 5e-05
Identities = 66/367 (17%), Positives = 140/367 (38%), Gaps = 56/367 (15%)
Query: 205 KLSPSPSLRKSSKSPKRKSSP----KSSSASKKDRKTSAVSSPLLDQQRNSKTNQSK--- 257
+L+ S + S SPK +S K+S ++ ++T VS+ Q ++ + +K
Sbjct: 331 QLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPY 390
Query: 258 --------KKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQRE 309
++G + PPPP K +++ DR R G F +++
Sbjct: 391 GKGPSFNQERGTSSHLPPPP--------KLLAQQHPPPDRQAVPGRPGP-----FPSKQQ 437
Query: 310 KRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369
D+ + S IS+ + + +R +RK + +R
Sbjct: 438 VADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEE--QRKAACAEKLKRL------- 488
Query: 370 SASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKD 429
L +++ SP R REK R + + ++ E+ + +R +EK+
Sbjct: 489 ------DEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKE 542
Query: 430 SREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDT 489
E+E E+ + ++ + ++E R + ++ + +E ++ RE
Sbjct: 543 KELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKERE------KL 596
Query: 490 KESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRN 549
+E +PR+ + + ++ E +E + + + R E T + +E+
Sbjct: 597 EEKIEPREP-NLEPMVEKQESENSCNKEEEPVFTRQDSN------RSEKEATPVVHETEP 649
Query: 550 ESRSEIR 556
ES S+ R
Sbjct: 650 ESGSQPR 656
Score = 47.4 bits (111), Expect = 1e-04
Identities = 61/303 (20%), Positives = 127/303 (41%), Gaps = 35/303 (11%)
Query: 1210 SNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSR--IDQLKRGE-PS----RS 1262
SN + +DQ + + ++ ++ + + + + ++ + ++ G+ PS R
Sbjct: 342 SNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKVPYGKGPSFNQERG 401
Query: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQRE 1322
TSS +++ P + V R G F S+ ++ + D R R+ Q E
Sbjct: 402 TSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQ-------QSE 454
Query: 1323 WDRDADKDWPRNRDRDRLRERERERE-RDKRRDLDR-----ERERLISDSVERDRDRDRD 1376
++ R + +R E +R+ +K + LD E++ + ER+R+++R+
Sbjct: 455 ISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKERE 514
Query: 1377 RTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKER-----MDKDLGSVQGFEETN 1431
R + E K E + E E E+D E L+KE+ M+K+ + E
Sbjct: 515 R-----EKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELER 569
Query: 1432 KSERTESLEAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMP 1491
+ E+ + L+ ++ K + E EP + L+ ++ EK+E + K
Sbjct: 570 QKEKEKELQKMKEQEKECELEKEREKLEEKIEP-REPNLEPMV----EKQESENSCNKEE 624
Query: 1492 DPL 1494
+P+
Sbjct: 625 EPV 627
Score = 34.7 bits (78), Expect = 0.74
Identities = 61/310 (19%), Positives = 116/310 (37%), Gaps = 65/310 (20%)
Query: 129 ITKERTPE------SEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQ 182
I+ +TP+ S++ N EWET + SD + +R++ +++ L
Sbjct: 1475 ISGNKTPDLSNQNSSDQANEEWETASESSDFNE-------------RRERDEKKNADLNA 1521
Query: 183 ENMEKREEIII--KKEVSPEVVRSKLSPSPSLRKSSKSP------------KRKSSPKSS 228
+ + K E ++ K+E++ S+ R+ + P +R+S P S
Sbjct: 1522 QTVVKVGENVLPPKREIAKRSFSSQRPVDRQNRRGNNGPPKSGRNFSGPRNERRSGPPSK 1581
Query: 229 SASK---KDRKTSAVSSPLLDQ--------------QRNSKTNQSKKKGPRTPSPPPPIP 271
S + D+ L++ Q+NSK + KK+ P P P
Sbjct: 1582 SGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDSTGKKREDPKPGPKKPKE 1641
Query: 272 EDIALGK----KYKEKYKVKDR-----IEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQ 322
+ AL + Y + D IE+ + D G ++++ + + +
Sbjct: 1642 KVDALSQFDLNNYASVVIIDDHPEVTVIEDPQSNLNDDGFTEVVSKKQQKRLQDEERRKK 1701
Query: 323 HHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLT----PPLRRSASPYPSHS 378
I + ++++ G S Q PR + + Q+ + PPL + P PS S
Sbjct: 1702 EEQVIQVWNKKNANEKGRS-QTSKLPPRFAKKQATGIQQAQSSASVPPLASAPLP-PSTS 1759
Query: 379 LSSPQRKQSP 388
S P +P
Sbjct: 1760 ASVPASTSAP 1769
Score = 32.7 bits (73), Expect = 2.8
Identities = 18/63 (28%), Positives = 30/63 (47%), Gaps = 1/63 (1%)
Query: 1085 ATATTPGSTPSPLSSLLP-PPPPVATATATTVPATLAATTAAAATSFSTSAITISTSATP 1143
A+A+ P P+P+S+ P PP P T T P T + ++ +I + ++ TP
Sbjct: 1907 ASASAPAPAPTPVSAPNPAPPAPAQTQAQTHKPVQNPLQTTSQSSKQPPPSIRLPSAQTP 1966
Query: 1144 TNT 1146
T
Sbjct: 1967 NGT 1969
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 122 bits (305), Expect = 4e-27
Identities = 92/318 (28%), Positives = 154/318 (48%), Gaps = 20/318 (6%)
Query: 650 RNDELERDERREERRVDRV-------DDRRDERARERDRERERDRERERERERERDRERE 702
+ D LE E R+ R + +D ++R E D + ++ +E+ R+ E
Sbjct: 10 KRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDE 69
Query: 703 KERELERERARERE---REREKERDRERDRDRDHDRERER-ERERDREKEREREREERER 758
K +E R R+ E R KE++RE +R + H E+++ RE +R+K RE RE R
Sbjct: 70 KRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRR 129
Query: 759 ERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHD 818
ER+R + ER+RERER + RE+ KE QR+ +++++ ++RR++RE RE
Sbjct: 130 ERDRLEQLERKRERER-KMREQQKE---QREQKERERRAEERRKEREARREVSAHHRTMR 185
Query: 819 ERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR---S 875
E S K + S SP + P+ R E ++K E+ LLS + +S S
Sbjct: 186 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK--EEKMEERDLLSDLQDISDSERKTS 243
Query: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
+ S E G +EE+ + E +E EE E +E+ +++ + E+S A+
Sbjct: 244 SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAE 303
Query: 936 DIIGHHQSEDRETSDRAH 953
++ SED E + H
Sbjct: 304 EVSEEEMSEDEERENENH 321
Score = 87.4 bits (215), Expect = 1e-16
Identities = 99/441 (22%), Positives = 175/441 (39%), Gaps = 80/441 (18%)
Query: 539 SRTEIRNESRNE-SRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE 597
S+++ R+ R+ E+R+ RM + P E S RG + DS + S +
Sbjct: 2 SQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRRED-SMEDRGEEDDSLAIKPPQQMSRK 60
Query: 598 TRSSYPERDRYPE-RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELER 656
+ + + ++ E R +R + + R E++R R + RH+ D+ R
Sbjct: 61 EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRK--------RHREEQDKARR 112
Query: 657 DERREERRVDRVDDRRDERARERDRERERDRERE-RERERERDREREKERELERERARER 715
+ R++RR + R ER R ER+R+RER+ RE+++E+ ++E+ER E ER +ER
Sbjct: 113 EWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAE-ERRKER 171
Query: 716 ERERE-----------------------------------------------KERDRERD 728
E RE +ERD D
Sbjct: 172 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSD 231
Query: 729 RDRDHDRERERE------------RERDREKEREREREERERERERERERERERERERER 776
D ER+ E + E+E E E E E E E E E E E
Sbjct: 232 LQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 291
Query: 777 ARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ 836
+ + + + +++ D+ RE + R D +S++ G +P+
Sbjct: 292 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 351
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSP----SHLTEDRQG-RWKE 891
S ++ PDS A + + K E + L + Q RS+ + + E G ++
Sbjct: 352 SALTEGDYVPDSPALSPIELKQELPKYLPAL---QGCRSVEEFQCLNRIEEGTYGVVYRA 408
Query: 892 EDRKPERKESSRRYEEQELKE 912
+D+K + + +R + ++ KE
Sbjct: 409 KDKKTDEIVALKRLKMEKEKE 429
Score = 80.5 bits (197), Expect = 1e-14
Identities = 73/286 (25%), Positives = 131/286 (45%), Gaps = 22/286 (7%)
Query: 1219 DDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLK-RGEPSRSTS--SDRQDSRS--- 1272
DD+ ++ L G R+ + I R D ++ RGE S + +Q SR
Sbjct: 5 DDRDSKRDSLEEGEL-RDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKV 63
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWP 1332
H + + R+ S S R++E++R R+R RE +D +REW+R ++
Sbjct: 64 HHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMA 123
Query: 1333 R---NRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
R R+RDRL + ER+RER+++ RE+++ + ER+R R +R E V
Sbjct: 124 REHSRRERDRLEQLERKRERERKM---REQQKEQREQKERER-RAEERRKEREARREVSA 179
Query: 1390 CEAKLEGEHERDLEST--SRDSLALDKERMDKDLGSVQGFEETNKSERTESL----EAGD 1443
+ ++ ++++ SR +ER +LG + + K E + L + D
Sbjct: 180 HHRTMREDYSDKVKASHWSRSPPRPPRERF--ELGDGRKPVKEEKMEERDLLSDLQDISD 237
Query: 1444 DESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
E K A S + +G G E ++E +E G + ++++EE+
Sbjct: 238 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 283
Score = 75.5 bits (184), Expect = 4e-13
Identities = 83/383 (21%), Positives = 149/383 (38%), Gaps = 45/383 (11%)
Query: 307 QREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366
Q + RD R + G+ R H +S R S + S + PP
Sbjct: 3 QSDDRDSKRDSLEEGE------LRDHRMEITIRNSPYRREDSMEDRGEEDDSL--AIKPP 54
Query: 367 LRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR 426
+ S H ++++ RHRS E G+H + + R HERR KR R
Sbjct: 55 QQMSRKEKVHHR--KDEKRKEKRRHRSHSAEGGKHARVKEKE---REHERR-----KRHR 104
Query: 427 EKDSREEREYEQD--QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRD 484
E+ + RE+E+ + +R+H R RDR + + + RE + ++ RE ++
Sbjct: 105 EEQDKARREWERQKRREMAREH-----SRRERDRLEQLERKRERERKMREQQKEQREQKE 159
Query: 485 YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
R +E R R++R AH T R++ + ++ + R+ R R E+
Sbjct: 160 RERRAEERRKEREARREVSAH-------HRTMREDYSDKVKASHWSRSPPRPPRERFEL- 211
Query: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
+ R ++ ++M R + +L + + S +S S+ S + S E
Sbjct: 212 ----GDGRKPVKEEKM-EERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEE 260
Query: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE-ER 663
+ E + + +S E E + + + S + +E+ DE RE E
Sbjct: 261 EEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 320
Query: 664 RVDRVDDRRDERARERDRERERD 686
+ V + R +R E E +
Sbjct: 321 HLLVVPESRFDRDSGESEEAEEE 343
Score = 62.4 bits (150), Expect = 3e-09
Identities = 75/301 (24%), Positives = 123/301 (40%), Gaps = 48/301 (15%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTK----SLEITGERKSR 1250
N R S R +DS Q RK +H ++ K K S G + +R
Sbjct: 30 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHAR 89
Query: 1251 IDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHD 1308
+ + +R R + QD +RR R+ +R S RDRL+ ER R
Sbjct: 90 VKEKEREHERRKRHREEQDK----ARREWERQKRREMAREHSRRERDRLEQLERKRERER 145
Query: 1309 RERERERRDTRQREWDRDADKDWPRNRDRDRLRE-------------------------- 1342
+ RE+++ Q+E +R A++ R ++R+ RE
Sbjct: 146 KMREQQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 202
Query: 1343 ---RERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEG 1396
RER D R+ + E+ ER L+SD + + + ESS ES E + E
Sbjct: 203 RPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEE 262
Query: 1397 EHERDLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHS 1453
E E + E STS +S ++E +++ + EE ++ +E E +DE + ++ H
Sbjct: 263 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 322
Query: 1454 L 1454
L
Sbjct: 323 L 323
Score = 59.7 bits (143), Expect = 2e-08
Identities = 71/377 (18%), Positives = 145/377 (38%), Gaps = 66/377 (17%)
Query: 783 ERERQRDWEDKDKGRDDRRE--------KREEIREDRNPRDGH-----DERKSKKRYRNE 829
+R+ +RD ++ + RD R E +RE+ EDR D ++ S+K +
Sbjct: 6 DRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHH 65
Query: 830 GSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQES----------RSLSPS 879
R+ +R R HS + + +K +H + Q+ R ++
Sbjct: 66 RKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 125
Query: 880 HLTEDRQGRWK-EEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDII 938
H +R + E R+ ERK ++ E++E KE+ +++R++ E +++
Sbjct: 126 HSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA-------RREVS 178
Query: 939 GHHQSEDRETSDRAHDENKKKAKIQ-----------KKPIKKKKEDDVGIERGNIETTSE 987
HH++ + SD+ + ++ + +KP+K++K ++ +
Sbjct: 179 AHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDL--------LS 230
Query: 988 DGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCN 1047
D Q S + + + + G + +EE ++ + + +EE E
Sbjct: 231 DLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEET 290
Query: 1048 GKNGILEDSQKKEDTAFSDWSDED----------VP------DRTEVTEAEHTATATTPG 1091
G N Q E+ + + S+++ VP D E EAE TP
Sbjct: 291 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQ 350
Query: 1092 STPSPLSSLLPPPPPVA 1108
S+ +P P ++
Sbjct: 351 SSALTEGDYVPDSPALS 367
Score = 56.6 bits (135), Expect = 2e-07
Identities = 67/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND-SAH 1215
H + R R+E++E + RK +Q++ R R+ + R + SAH
Sbjct: 126 HSRRERDRLEQLERKR-----ERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180
Query: 1216 RSG--DDQSGRKRVLH-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRS 1272
+D S + + H S S R + E+ G+ + + + K E R SD QD S
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFEL-GDGRKPVKEEKMEE--RDLLSDLQDI-S 236
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWP 1332
S R++S S SGS + +E + E + E + E + + +++
Sbjct: 237 DSERKTSSAESSSAESGSGSEE-----EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 291
Query: 1333 RNRDRDRLRERERERERDKRRDLDRERER--LISDSVERDRDRDRDRTFESSQIESVKRC 1390
N + + E E + D +RE E L+ DRD E E +
Sbjct: 292 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 351
Query: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAG 1442
A EG++ D + S L K+ + K L ++QG + + +E G
Sbjct: 352 SALTEGDYVPDSPALSPIEL---KQELPKYLPALQGCRSVEEFQCLNRIEEG 400
Score = 50.1 bits (118), Expect = 2e-05
Identities = 79/375 (21%), Positives = 138/375 (36%), Gaps = 47/375 (12%)
Query: 151 SDNGDINYDYVHELSLEMKRQKIQ-RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPS 209
SD+ D D + E L R +I R +++ME R E + P P
Sbjct: 4 SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKP--------PQ 55
Query: 210 PSLRKSS----KSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPS 265
RK K KRK + S S + K + V + +R + + + K R
Sbjct: 56 QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWE 115
Query: 266 PPPPIPEDIA-------------LGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRD 312
++A L +K + + K++++ +E+ R+ K+R R E +R++R+
Sbjct: 116 RQKR--REMAREHSRRERDRLEQLERKRERERKMREQQKEQ-REQKERERRAEERRKERE 172
Query: 313 KPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSAS 372
R S HH + R S S R P P R+R ++ +
Sbjct: 173 ARREVSA---HHRTM--REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERD 227
Query: 373 PYPS-HSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSR 431
+S +RK S S G + E + E E+ + E++
Sbjct: 228 LLSDLQDISDSERKTSSAESSSAESGSGSEEEE------EEEEEEEEEGSTSEESEEEEE 281
Query: 432 EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRE-----LRDSRDMRDSREMRDYS 486
EE E E++ S+ + ++ + + + D E + +SR RDS E +
Sbjct: 282 EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAE 341
Query: 487 RDTKESRDPRDSRST 501
+ E P+ S T
Sbjct: 342 EEVGEG-TPQSSALT 355
Score = 49.3 bits (116), Expect = 3e-05
Identities = 64/317 (20%), Positives = 128/317 (40%), Gaps = 39/317 (12%)
Query: 798 DDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDK 857
DDR KR+ + E + R + SP R+ R DS A
Sbjct: 5 DDRDSKRDSLEEG-------ELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQM 57
Query: 858 NEKHRLLSQVVRPQESRSLSPSHLTED-RQGRWKEEDRKPERK-------ESSRRYEEQE 909
+ K ++ + ++ + SH E + R KE++R+ ER+ + +RR E++
Sbjct: 58 SRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQ 117
Query: 910 LKEKVSSVDKQREQTEILESSRMRAQD-IIGHHQSEDRETSDRAH--DENKKKAKIQK-- 964
+ +++ +RE+ + + R R ++ + Q E RE +R +E +K+ + ++
Sbjct: 118 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 177
Query: 965 ----KPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS--KGDSDISD 1018
+ +++ D V + + F G+K EK ++ DISD
Sbjct: 178 SAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 237
Query: 1019 EEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEV 1078
E S + + + +EE E+ +++E+ + S+ S+E+ + E
Sbjct: 238 SERKTSSAESSSAESGSGSEEEE-----------EEEEEEEEEGSTSEESEEE--EEEEE 284
Query: 1079 TEAEHTATATTPGSTPS 1095
E E T + + S S
Sbjct: 285 EEEEETGSNSEEASEQS 301
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 194 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 253
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 254 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 306
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 307 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 358
Score = 40.4 bits (93), Expect = 0.014
Identities = 74/391 (18%), Positives = 130/391 (33%), Gaps = 70/391 (17%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEES----SSPVRKESSRGRHREKEDIKIT 130
R SP R + +R + PQ+ + +E RKE R R E K
Sbjct: 29 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK-- 86
Query: 131 KERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190
R E E E+ + +R++ D ++ + EM R+ +RE +LEQ ++ E
Sbjct: 87 HARVKEKEREHERRKRHREEQDKA--RREWERQKRREMAREHSRRERDRLEQLERKRERE 144
Query: 191 IIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRN 250
K+ ++ K +R++ + + R+ SA + +
Sbjct: 145 -------------RKMREQQKEQREQKERERRAEERRKEREAR-REVSAHHRTMREDY-- 188
Query: 251 SKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREK 310
+ K + SPP P E LG K ++E+ + +D D + +
Sbjct: 189 ---SDKVKASHWSRSPPRPPRERFELGDGRKP-------VKEEKMEERDLLSDLQ---DI 235
Query: 311 RDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRS 370
D R TS A SSS++SGS + +
Sbjct: 236 SDSERKTSSA-----------ESSSAESGSGSEEEEEEEEEEE----------------- 267
Query: 371 ASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDS 430
+S + ++ E G + E + QS + E +R+ E
Sbjct: 268 -----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 322
Query: 431 REEREYEQDQSSSRDHRDDREPRDGRDRRDA 461
E D+ S + E +G + A
Sbjct: 323 LVVPESRFDRDSGESEEAEEEVGEGTPQSSA 353
Score = 33.5 bits (75), Expect = 1.7
Identities = 63/400 (15%), Positives = 139/400 (34%), Gaps = 53/400 (13%)
Query: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
+S S + ++ +E + + R E + R ++ + ++ + I +M +
Sbjct: 1 MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60
Query: 936 DIIGHHQSEDRETSDR---------AHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
+ + H + E R+ R H K+K + ++ + ++E D +
Sbjct: 61 EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120
Query: 987 EDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMC 1046
E + S ++ + + +E+KR++ + + E+ Q+ +++R
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRA---------------- 164
Query: 1047 NGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSPLSSLLPPPPP 1106
+ ++KE A R EV+ T + S PP PP
Sbjct: 165 --------EERRKEREA-----------RREVSAHHRTMREDYSDKVKASHWSRSPPRPP 205
Query: 1107 VATATATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVE 1166
+ S IS S T++ ++ A S + E
Sbjct: 206 RERFELGDGRKPVKEEKMEERDLLS-DLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 264
Query: 1167 KVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKR 1226
+ E T E+++ + +++ GSN S S S S ++++
Sbjct: 265 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN-HLL 323
Query: 1227 VLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSD 1266
V+ DR+ +GE + +++ G P S ++
Sbjct: 324 VVPESRFDRD-------SGESEEAEEEVGEGTPQSSALTE 356
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 121 bits (304), Expect = 5e-27
Identities = 99/374 (26%), Positives = 170/374 (45%), Gaps = 49/374 (13%)
Query: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERD-RRDNRERDQRPSSPIRHQGRND 652
DSW+ ++ R +++ + + +RD +RD+ E + + RN
Sbjct: 6 DSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNS 65
Query: 653 ELERDERREERRVDRVDDR----------RDERARERDRERERDRERERERERERDRERE 702
R++ E+R + DD R E+ R E+ ++++ R +E+ER+ ER
Sbjct: 66 PYRREDSMEDRGEE--DDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERR 123
Query: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
K E+++AR RE ER + R+ R+H R RER+R E++RERER+ RE+++E+
Sbjct: 124 KRHREEQDKAR-----REWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQKEQ 177
Query: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
++ERER RA ER KERE +RE R R+ + ++
Sbjct: 178 REQKERER-----RAEERRKERE----------------ARREVSAHHRTMREDYSDKVK 216
Query: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR---SLSPS 879
+ S SP + P+ R E ++K E+ LLS + +S S + S
Sbjct: 217 ASHW----SRSPPRPPRERFELGDGRKPVK--EEKMEERDLLSDLQDISDSERKTSSAES 270
Query: 880 HLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIG 939
E G +EE+ + E +E EE E +E+ +++ + E+S A+++
Sbjct: 271 SSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSE 330
Query: 940 HHQSEDRETSDRAH 953
SED E + H
Sbjct: 331 EEMSEDEERENENH 344
Score = 89.7 bits (221), Expect = 2e-17
Identities = 88/384 (22%), Positives = 154/384 (40%), Gaps = 46/384 (11%)
Query: 542 EIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSS 601
E + E ++EI+ + R + E+G +I +S DS E
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSME---- 74
Query: 602 YPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE 661
DR E D+ R+ R+D + ++++ R E ER+ R
Sbjct: 75 ----DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKK-------HARVKEKEREHERR 123
Query: 662 ERRVDRVDDRRDERARERDRERERD---RERERERERERDRERE-KERELERERARERER 717
+R + D R E R++ RE R+ RER+R + ER RERE K RE ++E+ ++ER
Sbjct: 124 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 183
Query: 718 ER---EKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERER 774
ER E+ ++RE R+ RE D+ K R RER + + +
Sbjct: 184 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 243
Query: 775 ERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSP 834
E+ ERD + Q D +R+ E + +E + ++ EGS S
Sbjct: 244 EKMEERDLLSDLQ------DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE 297
Query: 835 RQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDR 894
+ E + + ++ ++ +E Q + +S ++ED + +E +
Sbjct: 298 ESEEEEEEEEEEEEETGSNSEEASE-----------QSAEEVSEEEMSEDEE---RENEN 343
Query: 895 K----PERKESSRRYEEQELKEKV 914
PE + E +E +E+V
Sbjct: 344 HLLVVPESRFDRDSGESEEAEEEV 367
Score = 87.8 bits (216), Expect = 7e-17
Identities = 88/367 (23%), Positives = 143/367 (38%), Gaps = 27/367 (7%)
Query: 426 REKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMR-DSREMRD 484
+EK R+E+E + + ++ D RD + + RD +R+S R DS E R
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRG 77
Query: 485 YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
D+ + P+ H +D + ++ +K E+ R + R R + + R
Sbjct: 78 EEDDSLAIKPPQQMSRKEKVHHRKDEKRKE--KKHARVKEKEREHERRK-RHREEQDKAR 134
Query: 545 NESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPE 604
E + R E+ + R R R+ +L K R + + + E
Sbjct: 135 REWERQKRREMAREHSRRERDRLEQLERKRER------------ERKMREQQKEQREQKE 182
Query: 605 RDRYPE--RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDEL------ER 656
R+R E R R+ R+ S R D D + SP R EL +
Sbjct: 183 RERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVK 242
Query: 657 DERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERE 716
+E+ EER D + D +D ER E E + E E+E E E + E E
Sbjct: 243 EEKMEER--DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESE 300
Query: 717 REREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERER 776
E E+E + E + + + E+ E E+E E EERE E E +R+
Sbjct: 301 EEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS-EDEERENENHLLVVPESRFDRDSGE 359
Query: 777 ARERDKE 783
+ E ++E
Sbjct: 360 SEEAEEE 366
Score = 77.8 bits (190), Expect = 8e-14
Identities = 78/308 (25%), Positives = 134/308 (43%), Gaps = 57/308 (18%)
Query: 1233 RDREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDS-------------------RS 1272
+D K K+L EI E+K R +Q ++ E R +SD +DS R+
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRN 64
Query: 1273 HSSRRSSPESDR-------------------QVHSRSG---SFDSRDRLQERDRYEHDRE 1310
RR DR +VH R R++E++R R+
Sbjct: 65 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRK 124
Query: 1311 RERERRDTRQREWDRDADKDWPR---NRDRDRLRERERERERDKRRDLDRERERLISDSV 1367
R RE +D +REW+R ++ R R+RDRL + ER+RER+++ RE+++ +
Sbjct: 125 RHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM---REQQKEQREQK 181
Query: 1368 ERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLEST--SRDSLALDKERMDKDLGSVQ 1425
ER+R R +R E V + ++ ++++ SR +ER +LG +
Sbjct: 182 ERER-RAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF--ELGDGR 238
Query: 1426 GFEETNKSERTESL----EAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKR 1481
+ K E + L + D E K A S + +G G E ++E +E G +
Sbjct: 239 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 298
Query: 1482 EDQQDEEK 1489
++++EE+
Sbjct: 299 SEEEEEEE 306
Score = 72.4 bits (176), Expect = 3e-12
Identities = 70/305 (22%), Positives = 127/305 (41%), Gaps = 31/305 (10%)
Query: 388 PPRHRSPMREKGRH--DHERTSQSHDRRHER-REDTRGKRDREKDSREEREYEQD--QSS 442
PP+ S +EK H D +R + H R E+ RE R KR RE+ + RE+E+ +
Sbjct: 87 PPQQMS-RKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREM 145
Query: 443 SRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTR 502
+R+H R RDR + + + RE + ++ RE ++ R +E R R++R
Sbjct: 146 AREH-----SRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 200
Query: 503 DAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGR 562
AH T R++ + ++ + R+ R R E+ + R ++ ++M
Sbjct: 201 SAH-------HRTMREDYSDKVKASHWSRSPPRPPRERFEL-----GDGRKPVKEEKM-E 247
Query: 563 SRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSF 622
R + +L + + S +S S+ S + S E + E + + +S
Sbjct: 248 ERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGSTSEESEE 301
Query: 623 ERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDR 681
E E + + + S + +E+ DE RE E + V + R +R
Sbjct: 302 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 361
Query: 682 ERERD 686
E E +
Sbjct: 362 EAEEE 366
Score = 66.6 bits (161), Expect = 2e-10
Identities = 78/403 (19%), Positives = 162/403 (40%), Gaps = 56/403 (13%)
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE--- 802
EK+ + + E +E++R +E+E + E +R + D +R+ +RD ++ + RD E
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-DRDSKRDSLEEGELRDHCMEITI 62
Query: 803 -----KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDK 857
+RE+ EDR D K ++ + R+ KR+ + ++
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 858 NEKHRLLSQVVRP----QESRSLSPSHLTEDRQGRWK-EEDRKPERKESSRRYEEQELKE 912
++HR R Q+ R ++ H +R + E R+ ERK ++ E++E KE
Sbjct: 123 RKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKE 182
Query: 913 KVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQ--------- 963
+ +++R++ E +++ HH++ + SD+ + ++ +
Sbjct: 183 RERRAEERRKEREA-------RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG 235
Query: 964 --KKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEA 1021
+KP+K++K ++ + D Q S + + + + G + +EE
Sbjct: 236 DGRKPVKEEKMEERDL--------LSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE 287
Query: 1022 AQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDED---------- 1071
++ + + +EE E G N Q E+ + + S+++
Sbjct: 288 EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 347
Query: 1072 VP------DRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVA 1108
VP D E EAE TP S+ +P P ++
Sbjct: 348 VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 390
Score = 60.1 bits (144), Expect = 2e-08
Identities = 73/297 (24%), Positives = 121/297 (40%), Gaps = 51/297 (17%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQL 1254
N R S R +DS Q RK +H ++ K K + +R+ +
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-------KHARVKEK 116
Query: 1255 KRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHDRERE 1312
+R R + QD +RR R+ +R S RDRL+ ER R + RE
Sbjct: 117 EREHERRKRHREEQDK----ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 172
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRE-----------------------------R 1343
+++ Q+E +R A++ R ++R+ RE R
Sbjct: 173 QQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 229
Query: 1344 ERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHER 1400
ER D R+ + E+ ER L+SD + + + ESS ES E + E E E
Sbjct: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 289
Query: 1401 DLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHSL 1454
+ E STS +S ++E +++ + EE ++ +E E +DE + ++ H L
Sbjct: 290 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 346
Score = 58.2 bits (139), Expect = 6e-08
Identities = 82/425 (19%), Positives = 160/425 (37%), Gaps = 71/425 (16%)
Query: 85 LRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEW 144
L+E+ + K Q+ E ++ + R G R+ ++IT +P E+++E
Sbjct: 17 LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRD-HCMEITIRNSPYRREDSMED 75
Query: 145 ETNRDDSDNGDINYDYVHELSLEMKRQKIQRELM--KLEQENMEKREEIIIKKEVSPEVV 202
DDS L+++ +Q ++E + + +++ EK+ + +KE E
Sbjct: 76 RGEEDDS------------LAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERR 123
Query: 203 RSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPR 262
+ R+ + KR+ + S ++DR L+Q
Sbjct: 124 KRHREEQDKARREWERQKRREMAREHSRRERDR---------LEQ--------------- 159
Query: 263 TPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQ 322
L +K + + K++++ +E+ R+ K+R R E +R++R+ R S
Sbjct: 160 -------------LERKRERERKMREQQKEQ-REQKERERRAEERRKEREARREVSA--- 202
Query: 323 HHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPS-HSLSS 381
HH + R S S R P P R+R ++ + +S
Sbjct: 203 HHRTM--REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISD 260
Query: 382 PQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQS 441
+RK S S G + E + E E+ + E++ EE E E++
Sbjct: 261 SERKTSSAESSSAESGSGSEEEE------EEEEEEEEEGSTSEESEEEEEEEEEEEEETG 314
Query: 442 SSRDHRDDREPRDGRDRRDARDTRDRRE-----LRDSRDMRDSREMRDYSRDTKESRDPR 496
S+ + ++ + + + D E + +SR RDS E + + E P+
Sbjct: 315 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEG-TPQ 373
Query: 497 DSRST 501
S T
Sbjct: 374 SSALT 378
Score = 56.6 bits (135), Expect = 2e-07
Identities = 67/292 (22%), Positives = 115/292 (39%), Gaps = 23/292 (7%)
Query: 1157 HRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND-SAH 1215
H + R R+E++E + RK +Q++ R R+ + R + SAH
Sbjct: 149 HSRRERDRLEQLERKR-----ERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 203
Query: 1216 RSG--DDQSGRKRVLH-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRS 1272
+D S + + H S S R + E+ G+ + + + K E R SD QD S
Sbjct: 204 HRTMREDYSDKVKASHWSRSPPRPPRERFEL-GDGRKPVKEEKMEE--RDLLSDLQDI-S 259
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWP 1332
S R++S S SGS + +E + E + E + E + + +++
Sbjct: 260 DSERKTSSAESSSAESGSGSEE-----EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETG 314
Query: 1333 RNRDRDRLRERERERERDKRRDLDRERER--LISDSVERDRDRDRDRTFESSQIESVKRC 1390
N + + E E + D +RE E L+ DRD E E +
Sbjct: 315 SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQS 374
Query: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAG 1442
A EG++ D + S L K+ + K L ++QG + + +E G
Sbjct: 375 SALTEGDYVPDSPALSPIEL---KQELPKYLPALQGCRSVEEFQCLNRIEEG 423
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 217 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 276
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 277 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 329
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 330 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 381
Score = 38.5 bits (88), Expect = 0.051
Identities = 72/390 (18%), Positives = 132/390 (33%), Gaps = 75/390 (19%)
Query: 83 GDLRER-----MKNKRQDVDTEPQKRNTEESSSPVRKESSRGR-----HREKEDIKITKE 132
G+LR+ ++N + + R E+ S ++ R HR+ E K K
Sbjct: 51 GELRDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKH 110
Query: 133 -RTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEI 191
R E E E+ + +R++ D ++ + EM R+ +RE +LEQ ++ E
Sbjct: 111 ARVKEKEREHERRKRHREEQDKA--RREWERQKRREMAREHSRRERDRLEQLERKRERE- 167
Query: 192 IIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNS 251
K+ ++ K +R++ + + R+ SA + +
Sbjct: 168 ------------RKMREQQKEQREQKERERRAEERRKEREAR-REVSAHHRTMREDY--- 211
Query: 252 KTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKR 311
+ K + SPP P E LG K ++E+ + +D D + +
Sbjct: 212 --SDKVKASHWSRSPPRPPRERFELGDGRKP-------VKEEKMEERDLLSDLQ---DIS 259
Query: 312 DKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSA 371
D R TS A SSS++SGS + +
Sbjct: 260 DSERKTSSA-----------ESSSAESGSGSEEEEEEEEEEE------------------ 290
Query: 372 SPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSR 431
+S + ++ E G + E + QS + E +R+ E
Sbjct: 291 ----EEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 346
Query: 432 EEREYEQDQSSSRDHRDDREPRDGRDRRDA 461
E D+ S + E +G + A
Sbjct: 347 VVPESRFDRDSGESEEAEEEVGEGTPQSSA 376
Score = 35.0 bits (79), Expect = 0.57
Identities = 67/424 (15%), Positives = 153/424 (36%), Gaps = 57/424 (13%)
Query: 854 GDDKNE-KHRLLSQVVRPQESRS----------LSPSHLTEDRQGRWKEEDRKPERKESS 902
GD+K+ K + L ++++ ++ R L S + ++ +E + + E +
Sbjct: 2 GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEIT 61
Query: 903 RRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKI 962
R ++ + ++ + I +M ++ + H + E R+ ++ H K+K +
Sbjct: 62 IRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRK--EKKHARVKEKERE 119
Query: 963 QKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAA 1022
++ + ++E D + E + S ++ + + +E+KR++ + + E+
Sbjct: 120 HERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQRE 179
Query: 1023 QQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082
Q+ +++R + ++KE A R EV+
Sbjct: 180 QKERERRA------------------------EERRKEREA-----------RREVSAHH 204
Query: 1083 HTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTSAT 1142
T + S PP PP + S IS S
Sbjct: 205 RTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS-DLQDISDSER 263
Query: 1143 PTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHT 1202
T++ ++ A S + E+ E T E+++ + +++ GSN S
Sbjct: 264 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 323
Query: 1203 SGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS 1262
S S S ++++ V+ DR+ +GE + +++ G P S
Sbjct: 324 SAEEVSEEEMSEDEERENEN-HLLVVPESRFDRD-------SGESEEAEEEVGEGTPQSS 375
Query: 1263 TSSD 1266
++
Sbjct: 376 ALTE 379
Score = 35.0 bits (79), Expect = 0.57
Identities = 39/243 (16%), Positives = 98/243 (40%), Gaps = 8/243 (3%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRK-ESSRGRHREKEDIKITKER 133
+R E RE + KR+++ E +R + RK E R ++++ + KER
Sbjct: 124 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 183
Query: 134 TPESEEENVEWETNRD-DSDNGDINYDYVHELSL---EMKRQKIQRELMKLEQENMEKRE 189
+EE E E R+ + + + DY ++ + RE +L +E
Sbjct: 184 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 243
Query: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQR 249
E + ++++ ++ S + S S + S + +++ + +S +++
Sbjct: 244 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 303
Query: 250 NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDR---IEEKTRDGKDRGRDFER 306
+ + ++ G + E+++ + +++ + + + ++R +D G E
Sbjct: 304 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 363
Query: 307 QRE 309
+ E
Sbjct: 364 EEE 366
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 121 bits (303), Expect = 6e-27
Identities = 88/345 (25%), Positives = 179/345 (51%), Gaps = 25/345 (7%)
Query: 636 ERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERER 695
E+ Q IR Q +E R++ + RR + + ++E+ R ++ E+ R E
Sbjct: 314 EKIQEQEEKIREQ---EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEE 370
Query: 696 ERDREREKERELERERAREREREREKERDR-ERDRDRDHDRERERERERDREKERERERE 754
+ EK RELE E+ E+E+ RE+E R E ++ R+ ++ +E+E + R++E+ RE+E
Sbjct: 371 MMWEKEEKIRELE-EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 429
Query: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRR--EKREEIREDRN 812
E+ RE+E++ R+ E+ E+E+ RE +K +E++ W ++K R+ ++E++ E
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 813 PRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQE 872
R ++ +K +R E ++ R +E + EK R + +R QE
Sbjct: 490 IR-----KQEEKVWRQEEKMHDQEEKIREQEEKMWR--------QEEKIREQEEKIREQE 536
Query: 873 SRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE--QELKEKV-SSVDKQREQTEIL-- 927
+ + ++++ + E++ K + +E RR EE +E +EK+ +K REQ E +
Sbjct: 537 EKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWE 596
Query: 928 ESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972
+ ++R Q+ + Q E + E ++K + Q++ +++++E
Sbjct: 597 QEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 641
Score = 107 bits (268), Expect = 7e-23
Identities = 104/506 (20%), Positives = 227/506 (44%), Gaps = 41/506 (8%)
Query: 432 EEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKE 491
EE E+D S +R+ + +++ +++ +L +S +++ R +
Sbjct: 196 EELTKERDALSLELYRNTITDEELKEKN--AKLQEKLQLVESEKSEIQLNVKELKRKLER 253
Query: 492 SRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGR-NHLREESSRTEIRNESRNE 550
++ + + D+ +E + K EE+ + R N +EE + E
Sbjct: 254 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE 313
Query: 551 SRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPE 610
+ + + +++ ++ E EK R WE + R E
Sbjct: 314 EKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE---KMRRLEE 370
Query: 611 RDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDD 670
+ + E + E+++ +E ++ IR Q + E E R+E ++
Sbjct: 371 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI----- 425
Query: 671 RRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE---RDRER 727
R++ + R++E++ R+ E+ E+E+ RE EK +E E E R+ E+ RE+E R +E+
Sbjct: 426 -REQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQE-EMWRQEEKIREQEEIWRQKEK 483
Query: 728 DRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQ 787
+++ R++E + R EK ++E + RE+E + R+ E+ RE+E + + +K RE++
Sbjct: 484 MHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE 543
Query: 788 RDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPD 847
+++++ ++ EK +E + R + E++ K R + E R+ ++ E
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKE---KIREQEEKIWE---- 596
Query: 848 SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEE 907
+ EK R ++++ QE + + E + ++E++ E++E RR EE
Sbjct: 597 ---------QEEKIREQEEMMQEQEEK------MWEQEEKMCEQEEKMQEQEEKMRRQEE 641
Query: 908 QELKEKV---SSVDKQREQTEILESS 930
+ +++V +K +E E LE++
Sbjct: 642 KMWEQEVRLRQQEEKMQEHQEHLEAA 667
Score = 98.2 bits (243), Expect = 5e-20
Identities = 93/437 (21%), Positives = 196/437 (44%), Gaps = 75/437 (17%)
Query: 651 NDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE 710
N + E R+E ++ +++ E+ + + E+ RE+E + R+ + EKE ++ R+
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354
Query: 711 RAREREREREKERDRERDRDRDHD----RERERERERDREKEREREREERERERERERER 766
E+E + R E +++ E+ E+E+ RE+E +R+ EE+ RE+E+ +E+
Sbjct: 355 EEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQ 414
Query: 767 ERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRY 826
E + R+ E+ RE++ E+ R+ E K ++++ ++E+IRE+
Sbjct: 415 EAKMWRQEEKIREQE---EKIREQEKKMWRQEEKIHEQEKIREEEK-------------- 457
Query: 827 RNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ 886
R E RQ K R + + + + +E+ + +R QE +
Sbjct: 458 RQEQEEMWRQEEKIREQE----EIWRQKEKMHEQEK-----IRKQEEKV----------- 497
Query: 887 GRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDR 946
W++E++ +++E R EE+ +++ +K REQ E ++R Q+ Q E
Sbjct: 498 --WRQEEKMHDQEEKIREQEEKMWRQE----EKIREQEE-----KIREQEEKIREQEEMM 546
Query: 947 ETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKK 1006
+ + E ++K + Q+K +++E+ + + I + QK+K E++
Sbjct: 547 QEQEEKMGEQEEKMQEQEK--MRRQEEKIREQEEKI-------------REQKEKIREQE 591
Query: 1007 RKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSD 1066
K + + I ++E Q ++++ E+ +MC + + E +K
Sbjct: 592 EKIWEQEEKIREQEEMMQEQEEK--------MWEQEEKMCEQEEKMQEQEEKMRRQEEKM 643
Query: 1067 WSDEDVPDRTEVTEAEH 1083
W E + E EH
Sbjct: 644 WEQEVRLRQQEEKMQEH 660
Score = 80.5 bits (197), Expect = 1e-14
Identities = 122/613 (19%), Positives = 260/613 (42%), Gaps = 92/613 (15%)
Query: 486 SRDTKESRDPRDSRSTRDAHDYRDRE----GRDTHRKE---DTYPEESRSYGRNHLREES 538
S++T++S+ D H + DT +K+ T PE + S G + +E
Sbjct: 52 SKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 111
Query: 539 SRTEIRNES-RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN--SNYHDS 595
+ E+ R E +++ R+ + ++ S+ + Q++ + + S HDS
Sbjct: 112 KASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAV-KQLEGEARDLISRLHDS 170
Query: 596 WETRSSYPERDRYPERDNRDQARDS-SFERRHGERDRRD-NRERDQRPSSPIRHQGRNDE 653
W+ +QA + + +++ +R + +ERD R+ ++E
Sbjct: 171 WKFAGEL------------EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218
Query: 654 LERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKE---RELERE 710
L+ + + ++ V+ + E + +E +R ER + ++ + E + +EL+
Sbjct: 219 LKEKNAKLQEKLQLVESEKSE-IQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSV 277
Query: 711 RAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERE-RERERE 769
A+ + + E E ++ ++ R+ E+ ++ E E+ +E+EE+ RE+E + RE+E +
Sbjct: 278 SAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWE-EKIQEQEEKIREQEEKIREQEEK 336
Query: 770 RERERERARERDKERERQRD--WEDKDKGR---DDRREKREEIREDRNPRDGHDERKSKK 824
R+ E E++++ RQ + WE ++K R + EK E+IRE H++ K ++
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKM--HEQEKIRE 394
Query: 825 RYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTED 884
Q KR+ E +R QE R E
Sbjct: 395 -----------QEEKRQEEEK----------------------IREQEKRQ-------EQ 414
Query: 885 RQGRWKEEDRKPERKESSRRYEEQ--ELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQ 942
W++E++ E++E R E++ +EK+ +K RE+ + E M Q+ Q
Sbjct: 415 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQ 474
Query: 943 SEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKS 1002
E ++ H++ K + + +K +++K D + I E K ++++
Sbjct: 475 EEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHD---QEEKIREQEEKMWRQEEKIREQEEK 531
Query: 1003 IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEEL----VEMCNGKNGILEDSQK 1058
I ++ +K + EE Q+ ++K G + + +E++ ++ + I E +K
Sbjct: 532 IREQEEKIR-----EQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEK 586
Query: 1059 KEDTAFSDWSDED 1071
+ W E+
Sbjct: 587 IREQEEKIWEQEE 599
Score = 40.8 bits (94), Expect = 0.010
Identities = 53/284 (18%), Positives = 107/284 (37%), Gaps = 30/284 (10%)
Query: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESE 138
E +L E+M ++++ + + +KR EE K + +++ KI ++ E
Sbjct: 376 EEKIRELEEKM-HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 434
Query: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKRQ--------KIQRELMKL-EQENMEKRE 189
+E W + I + + EM RQ +I R+ K+ EQE + K+E
Sbjct: 435 QEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQR 249
E + ++E K+ + R+ K +K R+ ++ +Q
Sbjct: 495 EKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIRE----QEEMMQEQE 550
Query: 250 NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQ-R 308
Q +K + K +++ K++++ EEK R+ K++ R+ E +
Sbjct: 551 EKMGEQEEKMQEQE--------------KMRRQEEKIREQ-EEKIREQKEKIREQEEKIW 595
Query: 309 EKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRK 352
E+ +K R Q + +Q RR+
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 639
Score = 40.4 bits (93), Expect = 0.014
Identities = 52/287 (18%), Positives = 112/287 (39%), Gaps = 27/287 (9%)
Query: 1226 RVLHSGSRDREKTKSLEITGERKSRI-DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
R L ++EK + E + + +I +Q KR E + RQ+ + E ++
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE--QEAKMWRQEEKIREQEEKIREQEK 437
Query: 1285 QVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQRE--WD------------RDADKD 1330
++ + +++++E ++ + E R+ R++E W + +K
Sbjct: 438 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKV 497
Query: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390
W + E+ RE+E R ++ RE+ + ++ R+++ + + + ++
Sbjct: 498 WRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQE 557
Query: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDD 1450
E E E R E R+ +E+ +K + E + R + + E K+ +
Sbjct: 558 EKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWE 617
Query: 1451 AHSLGSGAGEGYEPISDDELDEILAGDAEKREDQ-----QDEEKMPD 1492
E + E +E + EK +Q Q EEKM +
Sbjct: 618 QEEKMCEQEEKMQ-----EQEEKMRRQEEKMWEQEVRLRQQEEKMQE 659
Score = 38.5 bits (88), Expect = 0.051
Identities = 53/272 (19%), Positives = 110/272 (40%), Gaps = 16/272 (5%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
R E+ K L + ++ D L + S S Q + R + + + ++ +
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 1293 FDS-RDRLQERD-RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERD 1350
+++QE++ + E+ RE+ + +R+ + +K+ R + + E+E + R
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR- 367
Query: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDL---ESTSR 1407
++ E+E I + E+ ++++ R E + E K E + E E + E R
Sbjct: 368 -LEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 426
Query: 1408 DSLALDKERMDKDLGSVQGFEETNK----SERTESLEAGDDESKLDDAHSLGSGAGEGYE 1463
+ +E+ K + E K +R E E E K+ + + + +E
Sbjct: 427 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE 486
Query: 1464 PISDDELDEILAGDAEKREDQQD-----EEKM 1490
+ +E + EK DQ++ EEKM
Sbjct: 487 QEKIRKQEEKVWRQEEKMHDQEEKIREQEEKM 518
Score = 37.7 bits (86), Expect = 0.088
Identities = 64/437 (14%), Positives = 162/437 (37%), Gaps = 62/437 (14%)
Query: 163 ELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEV-VRSKLSPSPSLRKSSKSPKR 221
+L+++ ++K++R + L Q+ ++ + + K+ S +++++ + + ++ +
Sbjct: 241 QLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEE 300
Query: 222 KSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYK 281
K + + + K + +Q+ + + K + E++ K+ K
Sbjct: 301 KMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ----------EEMMWEKEEK 350
Query: 282 ---------EKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHH 332
EK + R+EE + +++ R+ E + +++K R Q I R
Sbjct: 351 MRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI--REQ 408
Query: 333 SSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHR 392
+ + + R R + + ++K +
Sbjct: 409 EKRQEQEAKMWRQEEKIREQE-----------------------EKIREQEKKMWRQEEK 445
Query: 393 SPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREERE---------YEQDQSSS 443
+EK R + +R Q R E + + + R+K+ E+E + Q++
Sbjct: 446 IHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMH 505
Query: 444 RDHRDDREPRDGRDRRDARDTRDRRELRDSRD-MRDSREM---RDYSRDTKESRDPRDSR 499
RE + R++ + ++R+ + +R+ EM ++ +E + +
Sbjct: 506 DQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEK 565
Query: 500 STRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDR 559
R R++E + +KE +E + + +EE R + E + + ++
Sbjct: 566 MRRQEEKIREQEEKIREQKEKIREQEEKIWE----QEEKIREQEEMMQEQEEKMWEQEEK 621
Query: 560 MGRSRGRVPELPEKGSR 576
M ++ E EK R
Sbjct: 622 MCEQEEKMQEQEEKMRR 638
Score = 37.0 bits (84), Expect = 0.15
Identities = 27/122 (22%), Positives = 60/122 (49%), Gaps = 6/122 (4%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R E + E M+ + + + + +K +E +R++ + R +E E I+ KE+
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQEK---MRRQEEKIREQE-EKIREQKEKIR 588
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
E EE+ WE + ++ + ++ + ++ Q E M+ ++E M ++EE + ++
Sbjct: 589 EQEEKI--WEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 646
Query: 196 EV 197
EV
Sbjct: 647 EV 648
Score = 36.6 bits (83), Expect = 0.20
Identities = 33/164 (20%), Positives = 72/164 (43%), Gaps = 10/164 (6%)
Query: 1246 ERKSRIDQLKRGEPSRSTSSDRQDSRSHSSR-RSSPESDRQVHSRSGSFDSRDRLQERDR 1304
E K R + K + R + R E ++ + G + + + QE+ R
Sbjct: 508 EEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMR 567
Query: 1305 YEHDRERERERRDTRQREWDRD-ADKDWPRNRDRDRLRERERERERDKRRDLDRERERLI 1363
+ ++ RE+E + Q+E R+ +K W +++RE+E E +++ + + E++
Sbjct: 568 RQEEKIREQEEKIREQKEKIREQEEKIW---EQEEKIREQE-EMMQEQEEKMWEQEEKMC 623
Query: 1364 SDSVERDRDRDRDRTFESSQIES---VKRCEAKLEGEHERDLES 1404
+ ++ R E E +++ E K++ EH+ LE+
Sbjct: 624 EQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ-EHQEHLEA 666
Score = 31.6 bits (70), Expect = 6.3
Identities = 18/106 (16%), Positives = 48/106 (45%), Gaps = 3/106 (2%)
Query: 85 LRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEW 144
++E+ K +RQ+ Q+ E +R++ + +E+ KI ++ E+E W
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEE---KIREQEEMMQEQEEKMW 616
Query: 145 ETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190
E + + + ++ + ++ Q ++ ++E M++ +E
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 662
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 120 bits (301), Expect = 1e-26
Identities = 105/498 (21%), Positives = 224/498 (44%), Gaps = 23/498 (4%)
Query: 603 PERDRYPERDNRDQARDSSFERRHGERDRRD--NRERDQRPSSPIRHQGRNDELERDERR 660
P++ E D+ + S + + + + NR Q+ R + + E E +
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQE 318
Query: 661 EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE 720
+E ++ +++ E+ + R+ E E+E + R+ + EKE ++ R+ E+E +
Sbjct: 319 QEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 378
Query: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
R E +++ E+ ++EK RE+E + +E E+ RE+E+ +E+E + R E+
Sbjct: 379 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEK 438
Query: 781 DKERERQ-RDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK 839
+E+E + R+ E K ++++ ++E+IRE+ R +E ++ +E RQ K
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEK-RQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 840 RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK 899
+ + EK R + +R QE + +++ W+EE++ E++
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQE 557
Query: 900 ESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKK 959
+ +EE++ +E+ + +Q E+ E R ++ I Q E R+ + + ++K
Sbjct: 558 ---KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKI-REQEEKRQEQEEKMWKQEEK 613
Query: 960 AKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKG-QKKKSIEKKRKKSKGDSDI-S 1017
+ Q++ I +++E+ + + I E Q K G Q++K E++ K + + +
Sbjct: 614 IREQEEKI-QEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWR 672
Query: 1018 DEEAAQQSKKKRGPRTPPITTKEELVE------------MCNGKNGILEDSQKKEDTAFS 1065
EE ++ +KK + I +EE+++ MC + + E +K
Sbjct: 673 QEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Query: 1066 DWSDEDVPDRTEVTEAEH 1083
W E + E EH
Sbjct: 733 MWEQEVRLRQQEEKMQEH 750
Score = 118 bits (295), Expect = 5e-26
Identities = 99/457 (21%), Positives = 215/457 (47%), Gaps = 32/457 (7%)
Query: 524 EESRSYGRNHLREESSRTEIRNESRNESRSEIRN--DRMGRSRGRVPELPEKGSRGSRGS 581
EE ++E + + + E E +IR ++M R + E EK R
Sbjct: 299 EEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMM 358
Query: 582 QIDSHSSNSNYHDSWETRSSYPERDRYP-ERDNRDQARDSSFERRHGERDRRDNRERDQR 640
WE ++ E++ + + + + R++ + R+ +++
Sbjct: 359 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 418
Query: 641 PSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRE 700
IR Q + E E R+E ++ +++ E+ ++ R+ E+ E+E+ RE E+ +E
Sbjct: 419 ----IREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE 474
Query: 701 REKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERER 760
+E+ E + + E R+KE+ E++ ++ R++E + R++E+ RE+EE+ RE+
Sbjct: 475 QEEMWRQEEKIHEQEEIWRQKEKMHEQE-----EKIRKQEEKVWRQEEKIREQEEKIREQ 529
Query: 761 ERERERERERERERERA-RERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDE 819
E + R+ E+ RE+E RE +K E+++ WE+ EKR+E +ED+ R
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE---------EKRQE-QEDKMWRQEEKI 579
Query: 820 RKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPS 879
R+ +++ + Q KR+ + ++ EK + + +R QE +
Sbjct: 580 REQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQE 639
Query: 880 HLTEDRQGRWKEEDRKPERKESSRRYEEQEL---KEKVSSVDKQ-REQTEILESSRMRAQ 935
+T++++ + E++ K +E + +E+ + +EK+ +K+ REQ E ++R Q
Sbjct: 640 EMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE-----KIREQ 694
Query: 936 DIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKE 972
+ + Q E + E ++K + Q++ +++++E
Sbjct: 695 EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731
Score = 110 bits (275), Expect = 1e-23
Identities = 101/519 (19%), Positives = 235/519 (45%), Gaps = 65/519 (12%)
Query: 411 DRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRREL 470
+R ++++E+ +++ + EE+ EQ++ RE + R++ ++
Sbjct: 292 NRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKM 351
Query: 471 RDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYG 530
R +M +E + R +E ++ + R ++E + +E + +E
Sbjct: 352 RRQEEMMWEKE--EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK---- 405
Query: 531 RNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNS 590
+RE+ + + + R + + + + +M R ++ E EK
Sbjct: 406 ---IREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK--------------IRE 448
Query: 591 NYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGR 650
W E+++ E E+R + + E+ R + +
Sbjct: 449 QEKKMWRQEEKIHEQEKIREE-----------EKRQEQEEMWRQEEKIHEQEEIWRQKEK 497
Query: 651 NDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKE-RELER 709
E E R++E +V R++E+ RE++ E+ R++E + R+ E+ RE+E+ RE E+
Sbjct: 498 MHEQEEKIRKQEEKV----WRQEEKIREQE-EKIREQEEKMWRQEEKIREQEEMWREEEK 552
Query: 710 ERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERE 769
+E+ E EK +++E R ++ RE+E + R++E+ RE+EE+ +E+E + ++ E
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEE 612
Query: 770 RERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERK---SKKRY 826
+ RE+E E+ ++ E+K + ++++ ++EE+ +++ + G E K +++
Sbjct: 613 KIREQE---------EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKM 663
Query: 827 RNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQ 886
+ + RQ K R + ++ EK R ++++ QE + + E +
Sbjct: 664 QEQEETMWRQEEKIREQEKKIR-------EQEEKIREQEEMMQEQEEK------MWEQEE 710
Query: 887 GRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTE 925
++E++ E++E RR EE+ +++V ++ + E
Sbjct: 711 KMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 106 bits (264), Expect = 2e-22
Identities = 91/438 (20%), Positives = 204/438 (46%), Gaps = 24/438 (5%)
Query: 535 REESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHD 594
+EE R + R E + ++M R + E EK R
Sbjct: 326 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 385
Query: 595 SWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDEL 654
WE E + + + ++ E+R E R+ +R ++ + R + + E
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQE---EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQ 442
Query: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERE-RERERERDRE---REKERELERE 710
E R +E+++ R +++ E+ + R+ E+ +++E R+ E+ ++E R+KE+ E+E
Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQE 502
Query: 711 RAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERER 770
E+ R++E++ R+ ++ R+ + E+ RE+E ++ E+ RE+ E RE E+ E+E+
Sbjct: 503 ---EKIRKQEEKVWRQEEKIREQE-EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 771 ERERERARERDKERERQRDWEDKDKGRDDRREKREE-IREDRNPRDGHDER--KSKKRYR 827
E E+ +E++ + RQ E+K + ++++ ++EE IRE R +E+ K +++ R
Sbjct: 559 IWEEEKRQEQEDKMWRQ---EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIR 615
Query: 828 NEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQG 887
+ Q K R + + ++ EK + + QE + + E +
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEK------MQEQEET 669
Query: 888 RWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRE 947
W++E+ K +E R +E++++E+ + +Q E+ E ++ + + + R
Sbjct: 670 MWRQEE-KIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728
Query: 948 TSDRAHDENKKKAKIQKK 965
++ ++ + + ++K
Sbjct: 729 QEEKMWEQEVRLRQQEEK 746
Score = 104 bits (259), Expect = 8e-22
Identities = 88/445 (19%), Positives = 204/445 (45%), Gaps = 33/445 (7%)
Query: 397 EKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGR 456
EK R E+ + ++ R+E+ +++ + +EE +E+++ R E +
Sbjct: 321 EKIREQEEKIREQEEKMR-RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKM 379
Query: 457 DRRDARDTRDRRELRD----------SRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHD 506
R++ ++R+ R+ + R+ + R+ +E R ++++ R
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIRE-QEKRQEQEAKMWRQEEK 438
Query: 507 YRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTE----IRNESRNESRSEI--RNDRM 560
R++E + +++ + +E + + + +REE R E R E + + EI + ++M
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 561 GRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDS 620
++ + EK R + W E+ R E R++ +
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE----EKIREQEEMWREEEKMH 554
Query: 621 SFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERD 680
E+ E R++ ++ R IR Q E R+E ++ +++R E+ +
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQ------EEKVWRQEEKIREQEEKRQEQEEKMW 608
Query: 681 RERERDRERERERERERDREREKEREL-ERERAREREREREKERDRERDRDRDHDRERER 739
++ E+ RE+E + + + ++ RE+E ++ E+E + + E+ E++ + + +E+E
Sbjct: 609 KQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEE 668
Query: 740 ERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDD 799
R EK RE+E++ RE+E E+ RE+E + + E+ E++ E+ + E+K + +++
Sbjct: 669 TMWRQEEKIREQEKKIREQE-EKIREQEEMMQEQEEKMWEQE---EKMCEQEEKMQEQEE 724
Query: 800 RREKREEIREDRNPRDGHDERKSKK 824
+ ++EE ++ R E K ++
Sbjct: 725 KMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 93.2 bits (230), Expect = 2e-18
Identities = 118/641 (18%), Positives = 282/641 (43%), Gaps = 72/641 (11%)
Query: 486 SRDTKESRDPRDSRSTRDAHDYRDRE----GRDTHRKE---DTYPEESRSYGRNHLREES 538
S++T++S+ D H + DT +K+ T PE + S G + +E
Sbjct: 52 SKETRQSKLAEAKEQLTDHHPQTNPSVGTAASDTKKKKINNGTNPETTTSGGCHSPEDEQ 111
Query: 539 SRTEIRNES-RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN--SNYHDS 595
+ E+ R E +++ R+ + ++ S+ + Q++ + + S HDS
Sbjct: 112 KASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAV-KQLEGEARDLISRLHDS 170
Query: 596 WETRSSYPERDRYPERDNRDQARDS-SFERRHGERDRRD-NRERDQRPSSPIRHQGRNDE 653
W+ +QA + + +++ +R + +ERD R+ ++E
Sbjct: 171 WKFAGEL------------EQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218
Query: 654 LERDERREERRVDRVDDRRDE-----RARERDRERERDRERERERERERDREREKEREL- 707
L+ + + ++ V+ + E + +R ER + +++ + E D ++ + +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVS 278
Query: 708 --------ERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERE 759
E E +++E++ R+ ++ ++ + + + + E+ RE+E E+ RE+ E+
Sbjct: 279 AKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQE-EKIREQEEKM 337
Query: 760 RERER---ERERERERERERARERDKERERQRD--WEDKDKGR----------DDRREKR 804
R +E E+E + R+ E E++++ RQ + WE ++K R + RE
Sbjct: 338 RRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELE 397
Query: 805 EEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLL 864
E++ E R+ ++R+ +++ R + RQ + + + + ++ ++
Sbjct: 398 EKMHEQEKIREQEEKRQEEEKIREQ---EKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 454
Query: 865 SQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYE-----EQELKEKVSSVDK 919
Q + E + ++++ W++E++ E++E R+ E E++++++ V +
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514
Query: 920 QREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENK--KKAKIQKKPIKKKKEDDVGI 977
Q E+ E ++ + + + RE + +E K ++ KI ++ ++++ED +
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 978 ERGNIETTSEDGQVFSPK-KGQKKKSIEKKRKKSKGDSDISD-EEAAQQSKKKRGPRTPP 1035
+ I E K + Q++K E++ K K + I + EE Q+ ++K +
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
Query: 1036 ITTKEELVEMCNGKNG-----ILEDSQKKEDTAFSDWSDED 1071
I +EE+ + K G + E +K ++ + W E+
Sbjct: 635 IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEE 675
Score = 55.1 bits (131), Expect = 5e-07
Identities = 76/476 (15%), Positives = 179/476 (37%), Gaps = 46/476 (9%)
Query: 91 NKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDD 150
N++Q+ Q+ +E ++++ + R +E+ KI ++ +E + WE
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE---KIREQEEKMRRQEEMMWEKEEKM 351
Query: 151 SDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSP 210
++ ++ + ++ + Q E+M ++E M ++EE++ +KE + K+
Sbjct: 352 RRQEEMMWE-------KEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE 404
Query: 211 SLRKSSKSPKRKSSPKSSSASKKDRKTSAV--SSPLLDQQRNSKTNQSKKKGPRTPSPPP 268
+R+ + KR+ K K+ + + + + +Q Q KK +
Sbjct: 405 KIREQEE--KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQ------ 456
Query: 269 PIPEDIALGKKYKEKYKVKD-----RIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQH 323
E I +K +E+ K ++ R EEK + ++ R E+ E+ +K R
Sbjct: 457 --EEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514
Query: 324 HSPISSRHHSSSSQSGSSIQRHSPSPRR-----KRTPSPSYQRTLTPPLRRSASPYPSHS 378
+ + R R + Q + +R
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 379 LSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGK-----------RDRE 427
R+Q R EK R E+ + ++ ++ E R + R++E
Sbjct: 575 QEEKIREQEEKVWR--QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632
Query: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487
+ RE+ E Q+Q ++++ ++ +T R+E + + RE + R
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 488 DTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRN-HLREESSRTE 542
+ +E ++ + ++E + ++E +E + + + LR++ + +
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/276 (19%), Positives = 113/276 (40%), Gaps = 25/276 (9%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
R EK E E + R +Q + + R E R+ +
Sbjct: 455 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWR 514
Query: 1293 FDSRDRLQERDRYEHDRERERERRDTRQRE--WDRDADKDWPRNRDRDRLRERERERERD 1350
+ + R QE E + + R+ R++E W R+ +K + + + + +E+E +
Sbjct: 515 QEEKIREQEEKIREQEEKMWRQEEKIREQEEMW-REEEKMHEQEKIWEEEKRQEQEDKMW 573
Query: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFES----SQIESVKRCEAKLEGEHERDLESTS 1406
++ + RE+E + E+ R+++ R + Q E ++ E K++ + E+ E
Sbjct: 574 RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE--- 630
Query: 1407 RDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDD-----ESKLDDAHSLGSGAGEG 1461
++ ++E M ++ G +E E+ E ++ ++ E K+ + E
Sbjct: 631 QEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE---KKIREQ 687
Query: 1462 YEPISDDELDEILAGDAEKREDQQD-----EEKMPD 1492
E I + E E++ EK +Q++ EEKM +
Sbjct: 688 EEKIREQE--EMMQEQEEKMWEQEEKMCEQEEKMQE 721
Score = 42.0 bits (97), Expect = 0.005
Identities = 44/210 (20%), Positives = 96/210 (45%), Gaps = 28/210 (13%)
Query: 1298 RLQERDRYEHDRERERERRDTRQREWDRD-----ADKDWPRNRDRDRLRERERE--RERD 1350
R +E+ R + + RE E+ +++ W+ + DK W R +++RE+E + R+ +
Sbjct: 535 RQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMW---RQEEKIREQEEKVWRQEE 591
Query: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFE-SSQIESVKRCEAKLEGEHERDLESTSRDS 1409
K R+ + +R+ + + + ++ R++ + Q E ++ E K+ + E E +
Sbjct: 592 KIREQEEKRQEQ-EEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQE--QEEK 648
Query: 1410 LALDKERMDKDLGSVQGFEET----NKSERTESLEAGDDESKLDDAHSLGSGAGEGYEPI 1465
+ +E+M + +Q EET + R + + + E K+ + + E
Sbjct: 649 MGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMW-- 706
Query: 1466 SDDELDEILAGDAEKREDQQD-----EEKM 1490
E +E + EK ++Q++ EEKM
Sbjct: 707 ---EQEEKMCEQEEKMQEQEEKMRRQEEKM 733
Score = 40.0 bits (92), Expect = 0.018
Identities = 67/398 (16%), Positives = 142/398 (35%), Gaps = 43/398 (10%)
Query: 79 ERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESE 138
E +L E+M ++++ + + +KR EE K + +++ KI ++ E
Sbjct: 390 EEKIRELEEKM-HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE 448
Query: 139 EENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVS 198
+E W + +HE ++KI+ E + EQE M ++EE I ++E
Sbjct: 449 QEKKMWRQE-----------EKIHE------QEKIREEEKRQEQEEMWRQEEKIHEQE-- 489
Query: 199 PEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK 258
E+ R K K K + K + +++ K + Q+ + +
Sbjct: 490 -EIWRQKEKMHEQEEKIRKQ-EEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMW 547
Query: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR-GRDFERQREKRDKPRST 317
+ I E+ +K +E+ R EEK R+ +++ R E+ RE+ +K R
Sbjct: 548 REEEKMHEQEKIWEE----EKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEK-RQE 602
Query: 318 SPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSH 377
R Q R R++ Q
Sbjct: 603 QEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ---------------EE 647
Query: 378 SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYE 437
+ + K + +E+ E + +++ +E+ +++ +EE+ +E
Sbjct: 648 KMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWE 707
Query: 438 QDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRD 475
Q++ +E + R++ + LR +
Sbjct: 708 QEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 745
Score = 35.4 bits (80), Expect = 0.44
Identities = 48/283 (16%), Positives = 120/283 (42%), Gaps = 30/283 (10%)
Query: 1226 RVLHSGSRDREKTKSLEITGERKSRI-DQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDR 1284
R L ++EK + E + + +I +Q KR E + RQ+ + E ++
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQE--QEAKMWRQEEKIREQEEKIREQEK 451
Query: 1285 QVHSRSGSFDSRDRLQERDRYEHDRERERERRDT-------RQREWDRDADKDWPRN--- 1334
++ + +++++E ++ + E R+ RQ+E + ++ +
Sbjct: 452 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEK 511
Query: 1335 --RDRDRLRERERERERDKRRDLDRERERLISDSV---ERDRDRDRDRTFE----SSQIE 1385
R +++RE+E E+ R++ + R+ E++ E ++ ++++ +E Q +
Sbjct: 512 VWRQEEKIREQE-EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQED 570
Query: 1386 SVKRCEAKLEGEHER--DLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGD 1443
+ R E K+ + E+ E R+ +E+ +K + E + + + + +
Sbjct: 571 KMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630
Query: 1444 DESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQD 1486
E K+ + + E E + + E E + EK ++Q++
Sbjct: 631 QEEKIREQEEM---TQEQEEKMGEQE--EKMCEQEEKMQEQEE 668
Score = 32.3 bits (72), Expect = 3.7
Identities = 42/236 (17%), Positives = 92/236 (38%), Gaps = 24/236 (10%)
Query: 76 RSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTP 135
R E + E+M + + + + + EE K + +E+ED +E
Sbjct: 520 REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKI 579
Query: 136 ESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKK 195
+EE V W + E KRQ+ Q E M ++E + ++EE I ++
Sbjct: 580 REQEEKV-WRQEEKIREQ-------------EEKRQE-QEEKMWKQEEKIREQEEKIQEQ 624
Query: 196 EVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQ 255
E E +R + + ++ + K + +++ K + Q+ + +
Sbjct: 625 E---EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE 681
Query: 256 SKKKGPRTPSPPPPIPEDIALGKKYKEK-YKVKDRIEEKTRDGKDRGRDFERQREK 310
K + I E + ++ +EK ++ ++++ E+ +++ RQ EK
Sbjct: 682 KKIR-----EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732
Score = 31.6 bits (70), Expect = 6.3
Identities = 47/247 (19%), Positives = 97/247 (39%), Gaps = 29/247 (11%)
Query: 1233 RDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGS 1292
R E+ K L + ++ D L + S S Q + R + + + ++ +
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 1293 FDS-RDRLQERD---RYEHDRERERERRDTRQRE--WDRDADKDWPRNRDRDRLRERERE 1346
+++QE++ R + ++ RE+E + RQ E W+ K+ R + + E+E +
Sbjct: 309 IQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWE----KEEKMRRQEEMMWEKEEK 364
Query: 1347 RERD------------KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKL 1394
R ++ ++ E+E I + E+ ++++ R E + E K E +
Sbjct: 365 MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEK 424
Query: 1395 EGEHERDL---ESTSRDSLALDKERMDKDLGSVQGFEETNK----SERTESLEAGDDESK 1447
E E + E R+ +E+ K + E K +R E E E K
Sbjct: 425 RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEK 484
Query: 1448 LDDAHSL 1454
+ + +
Sbjct: 485 IHEQEEI 491
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 119 bits (298), Expect = 2e-26
Identities = 98/365 (26%), Positives = 169/365 (46%), Gaps = 22/365 (6%)
Query: 594 DSWETRSSYPERDRYPERDNRDQARDSSFERRHGERD-RRDNRERDQRPSSPIRHQGRND 652
DSW+ ++ R +++ + + +RD +RD+ E + + RN
Sbjct: 6 DSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNS 65
Query: 653 ELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERE-R 711
R++ E+R + DD + ++ +E+ R+ E+ +E+ R E + R
Sbjct: 66 PYRREDSMEDRGEE--DDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHAR 123
Query: 712 AREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERE 771
+ERE ER K E+D+ R RE +R+K RE RE RER+R + ER+RE
Sbjct: 124 VKEREHERRKRHREEQDKAR---------REWERQKRREMAREHSRRERDRLEQLERKRE 174
Query: 772 RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGS 831
RER + RE+ KE QR+ +++++ ++RR++RE RE E S K + S
Sbjct: 175 RER-KMREQQKE---QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWS 230
Query: 832 PSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR---SLSPSHLTEDRQGR 888
SP + P+ R E ++K E+ LLS + +S S + S E G
Sbjct: 231 RSPPRPPRERFELGDGRKPVK--EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 288
Query: 889 WKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRET 948
+EE+ + E +E EE E +E+ +++ + E+S A+++ SED E
Sbjct: 289 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEER 348
Query: 949 SDRAH 953
+ H
Sbjct: 349 ENENH 353
Score = 97.1 bits (240), Expect = 1e-19
Identities = 99/411 (24%), Positives = 164/411 (39%), Gaps = 53/411 (12%)
Query: 542 EIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSS 601
E + E ++EI+ + R + E+G +I +S DS E
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSME---- 74
Query: 602 YPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERRE 661
DR E D+ R+ R+D + +++ RH + E + R +
Sbjct: 75 ----DRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-----CRHHSHSAEGGKHARVK 125
Query: 662 ERRVDRVDDRRDERAR-ERDRERERDRERERERERERDREREKERELERERARERERERE 720
ER +R R+E+ + R+ ER++ RE RE R RER++ +LER+R RER
Sbjct: 126 EREHERRKRHREEQDKARREWERQKRREMAREHSR---RERDRLEQLERKRERER----- 177
Query: 721 KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER 780
+ RE+++E+ +KERER EER +ERE RE RE
Sbjct: 178 --------------KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMRE----- 218
Query: 781 DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKK-RYRNEGSPSPRQSPK 839
D+ DK K R RE DG K +K R+ S S
Sbjct: 219 --------DYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDS 270
Query: 840 RRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERK 899
R+ S +S + SG E+ + +E S S E+ + +EE+ +
Sbjct: 271 ERKTSSAESSSAESGSGSEEEE---EEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 327
Query: 900 ESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSD 950
E+S + E+ +E++S +++ + +L R G + + E +
Sbjct: 328 EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 378
Score = 78.2 bits (191), Expect = 6e-14
Identities = 75/291 (25%), Positives = 132/291 (45%), Gaps = 28/291 (9%)
Query: 1216 RSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLK-RGEPSRSTS------SDRQ 1268
++ DD+ ++ L G R+ + I R D ++ RGE S + R+
Sbjct: 36 KNSDDRDSKRDSLEEGEL-RDHCMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
Query: 1269 DSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDR-ERERERRDTRQREWDRDA 1327
+ H E R HS S R++ER EH+R +R RE +D +REW+R
Sbjct: 95 EKVHHRKDEKRKEKCRH-HSHSAEGGKHARVKER---EHERRKRHREEQDKARREWERQK 150
Query: 1328 DKDWPR---NRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQI 1384
++ R R+RDRL + ER+RER+++ RE+++ + ER+R R +R E
Sbjct: 151 RREMAREHSRRERDRLEQLERKRERERKM---REQQKEQREQKERER-RAEERRKEREAR 206
Query: 1385 ESVKRCEAKLEGEHERDLEST--SRDSLALDKERMDKDLGSVQGFEETNKSERTESL--- 1439
V + ++ ++++ SR +ER +LG + + K E + L
Sbjct: 207 REVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF--ELGDGRKPVKEEKMEERDLLSDL 264
Query: 1440 -EAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEK 1489
+ D E K A S + +G G E ++E +E G + ++++EE+
Sbjct: 265 QDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE 315
Score = 77.0 bits (188), Expect = 1e-13
Identities = 88/411 (21%), Positives = 162/411 (39%), Gaps = 45/411 (10%)
Query: 281 KEKYKVK--DRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQS 338
K+ +KVK D I ++ + K++ E +R K R + + R H
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGEL--RDHCMEITI 62
Query: 339 GSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREK 398
+S R S + S + PP + S H ++++ RH S E
Sbjct: 63 RNSPYRREDSMEDRGEEDDSL--AIKPPQQMSRKEKVHHR--KDEKRKEKCRHHSHSAEG 118
Query: 399 GRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQD--QSSSRDHRDDREPRDGR 456
G+H ++ +R HERR KR RE+ + RE+E+ + +R+H R R
Sbjct: 119 GKH-----ARVKEREHERR-----KRHREEQDKARREWERQKRREMAREH-----SRRER 163
Query: 457 DRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH 516
DR + + + RE + ++ RE ++ R +E R R++R AH T
Sbjct: 164 DRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH-------HRTM 216
Query: 517 RKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSR 576
R++ + ++ + R+ R R E+ + R ++ ++M R + +L +
Sbjct: 217 REDYSDKVKASHWSRSPPRPPRERFEL-----GDGRKPVKEEKM-EERDLLSDLQDISDS 270
Query: 577 GSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRE 636
+ S +S S+ S + S E + E + + +S E E + +
Sbjct: 271 ERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGS 324
Query: 637 RDQRPSSPIRHQGRNDELERDERRE-ERRVDRVDDRRDERARERDRERERD 686
+ S + +E+ DE RE E + V + R +R E E +
Sbjct: 325 NSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 375
Score = 67.4 bits (163), Expect = 1e-10
Identities = 81/415 (19%), Positives = 178/415 (42%), Gaps = 68/415 (16%)
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE--- 802
EK+ + + E +E++R +E+E + E +R + D +R+ +RD ++ + RD E
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-DRDSKRDSLEEGELRDHCMEITI 62
Query: 803 -----KREEIREDRNPRDGH-----DERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAY- 851
+RE+ EDR D ++ S+K + R+ R HS + +
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHA 122
Query: 852 ---NSGDDKNEKHRLLSQVVR----PQESRSLSPSHLTEDRQG-RWKEEDRKPERKESSR 903
++ ++HR R Q+ R ++ H +R E R+ ERK +
Sbjct: 123 RVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 182
Query: 904 RYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQ 963
+ E++E KE+ +++R++ E +++ HH++ + SD+ + ++ +
Sbjct: 183 QKEQREQKERERRAEERRKERE-------ARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 964 -----------KKPIKKKK----------EDDVGIERGNIETTSEDGQVFSPKKGQKKKS 1002
+KP+K++K +D ER S + S + ++++
Sbjct: 236 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 295
Query: 1003 IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPIT-------TKEELVEMCNGKNG---- 1051
E++ + S + +EE ++ +++ G + + ++EE+ E +N
Sbjct: 296 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 355
Query: 1052 ILEDSQKKEDTAFSDWSDEDV----PDRTEVTEAEHTATATTPGSTPSPLSSLLP 1102
++ +S+ D+ S+ ++E+V P + +TE ++ +P P L LP
Sbjct: 356 VVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDY--VPDSPALLPIELKQELP 408
Score = 59.3 bits (142), Expect = 3e-08
Identities = 83/356 (23%), Positives = 141/356 (39%), Gaps = 51/356 (14%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTK----SLEITGERKSR 1250
N R S R +DS Q RK +H ++ K K S G + +R
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHAR 123
Query: 1251 IDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHD 1308
+ + R R + QD +RR R+ +R S RDRL+ ER R
Sbjct: 124 VKE--REHERRKRHREEQDK----ARREWERQKRREMAREHSRRERDRLEQLERKRERER 177
Query: 1309 RERERERRDTRQREWDRDADKDWPRNRDRDRLRE-------------------------- 1342
+ RE+++ Q+E +R A++ R ++R+ RE
Sbjct: 178 KMREQQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 234
Query: 1343 ---RERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEG 1396
RER D R+ + E+ ER L+SD + + + ESS ES E + E
Sbjct: 235 RPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEE 294
Query: 1397 EHERDLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHS 1453
E E + E STS +S ++E +++ + EE ++ +E E +DE + ++ H
Sbjct: 295 EEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHL 354
Query: 1454 LGSGAGEGYEPISDDELDEILAGDAEKREDQQDE-EKMPDPLDVIDVDWSGLMPKH 1508
L + E E G+ + E + +PD ++ ++ +PK+
Sbjct: 355 LVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKY 410
Score = 52.0 bits (123), Expect = 4e-06
Identities = 74/371 (19%), Positives = 133/371 (35%), Gaps = 51/371 (13%)
Query: 247 QQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFER 306
++ +S ++ ++ PP + + + EK K K R + +G R ER
Sbjct: 68 RREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKER 127
Query: 307 QREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPP 366
+ E+R RH ++ RR+ ++R
Sbjct: 128 EHERR-----------------KRHREEQDKA-----------RRE------WERQKRRE 153
Query: 367 LRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDR 426
+ R S L +RK+ R +++ R ER ++ +RR ER +R+
Sbjct: 154 MAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKER----EARREV 209
Query: 427 EKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRD--RRELRDSRDMRDSREMRD 484
R RE D+ + H PR R+R + D R + E + RD+ +++D
Sbjct: 210 SAHHRTMREDYSDKVKA-SHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS--DLQD 266
Query: 485 YSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIR 544
S +++ S + + + E + +E + EES EE
Sbjct: 267 ISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS 326
Query: 545 NESRNESRSEIRNDRMGRSRGRVPE-----LPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599
E+ +S E+ + M R E +PE SR R S +S + +
Sbjct: 327 EEASEQSAEEVSEEEMSEDEERENENHLLVVPE--SRFDRDSG-ESEEAEEEVGEGTPQS 383
Query: 600 SSYPERDRYPE 610
S+ E D P+
Sbjct: 384 SALTEGDYVPD 394
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 226 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 285
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 286 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 338
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 339 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 390
Score = 35.8 bits (81), Expect = 0.33
Identities = 60/289 (20%), Positives = 106/289 (36%), Gaps = 30/289 (10%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEES----SSPVRKESSR--------GRH- 121
R SP R + +R + PQ+ + +E RKE R G+H
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHA 122
Query: 122 REKE-DIKITKERTPESEEENVEWETNRDDS---DNGDINYDYVHELSLEMKR------- 170
R KE + + K E ++ EWE + ++ D + +L + +R
Sbjct: 123 RVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 182
Query: 171 QKIQRELMKLEQENMEKREEIIIKKEVSP--EVVRSKLSPSPSLRKSSKSPKRKSSPKSS 228
QK QRE + E+ E+R+E ++EVS +R S S+SP R P+
Sbjct: 183 QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR--PPRER 240
Query: 229 SASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKD 288
RK V ++++ Q R S + G + +E+ + ++
Sbjct: 241 FELGDGRK--PVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 298
Query: 289 RIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQ 337
E T + + + E + E+ S + Q +S S +
Sbjct: 299 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 347
Score = 35.0 bits (79), Expect = 0.57
Identities = 39/243 (16%), Positives = 98/243 (40%), Gaps = 8/243 (3%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRK-ESSRGRHREKEDIKITKER 133
+R E RE + KR+++ E +R + RK E R ++++ + KER
Sbjct: 133 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 192
Query: 134 TPESEEENVEWETNRD-DSDNGDINYDYVHELSL---EMKRQKIQRELMKLEQENMEKRE 189
+EE E E R+ + + + DY ++ + RE +L +E
Sbjct: 193 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 252
Query: 190 EIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQR 249
E + ++++ ++ S + S S + S + +++ + +S +++
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEE 312
Query: 250 NSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDR---IEEKTRDGKDRGRDFER 306
+ + ++ G + E+++ + +++ + + + ++R +D G E
Sbjct: 313 EEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEA 372
Query: 307 QRE 309
+ E
Sbjct: 373 EEE 375
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 119 bits (297), Expect = 3e-26
Identities = 98/360 (27%), Positives = 166/360 (46%), Gaps = 27/360 (7%)
Query: 612 DNRDQARDSSFERRHGERDRRDNRERD---QRPSSPIRHQGRNDELERDERREE------ 662
D +D + + + E+ RR +E +R + + D LE E R+
Sbjct: 3 DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITI 62
Query: 663 -RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREK 721
R +D ++R E D + ++ +E+ R+ EK +E + R +E+ERE E+
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 722 ERDRERDRDRDHDRERERERERDREKEREREREERERE-----RERERERERERERERER 776
R+R R+ RE ER++ RE RE R ER + R+R + ER+RERER +
Sbjct: 123 ---RKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERER-K 178
Query: 777 ARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQ 836
RE+ KE QR+ +++++ ++RR++RE RE E S K + S SP +
Sbjct: 179 MREQQKE---QREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 837 SPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESR---SLSPSHLTEDRQGRWKEED 893
P+ R E ++K E+ LLS + +S S + S E G +EE+
Sbjct: 236 PPRERFELGDGRKPVK--EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEE 293
Query: 894 RKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953
+ E +E EE E +E+ +++ + E+S A+++ SED E + H
Sbjct: 294 EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENH 353
Score = 87.0 bits (214), Expect = 1e-16
Identities = 99/446 (22%), Positives = 171/446 (38%), Gaps = 78/446 (17%)
Query: 542 EIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS- 600
E + E ++EI+ + R + E+G +I +S DS E R
Sbjct: 19 EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGE 78
Query: 601 -------------SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRH 647
S E+ + + + R + + + + + E +RR +Q +
Sbjct: 79 EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWE 138
Query: 648 QGRNDELERDERREERRVDRVDDRRDERAR-ERDRERERD-RERERERERERDRERE-KE 704
+ + E+ R+ R ER D V RD + ER RERER RE+++E+ +++RER +E
Sbjct: 139 RQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEE 198
Query: 705 RELERERARE-----------------------------RER------------EREKER 723
R ERE RE RER E+ +ER
Sbjct: 199 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 258
Query: 724 DRERDRDRDHDRERERE------------RERDREKEREREREERERERERERERERERE 771
D D D ER+ E + E+E E E E E E E E E E
Sbjct: 259 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 318
Query: 772 RERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGS 831
E + + + + +++ D+ RE + R D +S++ G
Sbjct: 319 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGE 378
Query: 832 PSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSP----SHLTEDRQG 887
+P+ S ++ PDS A + + K E + L + Q RS+ + + E G
Sbjct: 379 GTPQSSALTEGDYVPDSPALSPIELKQELPKYLPAL---QGCRSVEEFQCLNRIEEGTYG 435
Query: 888 -RWKEEDRKPERKESSRRYEEQELKE 912
++ +D+K + + +R + ++ KE
Sbjct: 436 VVYRAKDKKTDEIVALKRLKMEKEKE 461
Score = 73.6 bits (179), Expect = 1e-12
Identities = 75/314 (23%), Positives = 132/314 (42%), Gaps = 60/314 (19%)
Query: 1233 RDREKTKSL-EITGERKSRIDQLKRGEPSRSTSSDRQDS-------------------RS 1272
+D K K+L EI E+K R +Q ++ E R +SD +DS R+
Sbjct: 5 KDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRN 64
Query: 1273 HSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDR-ERERERRDTRQREWDRDADKDW 1331
RR DR S + ++ +++ H + E+ +E++ R +E +R+ ++
Sbjct: 65 SPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER-- 122
Query: 1332 PRNRDRDRLRERERERERDKRRDLDRERER---------LISDSVER-DRDRDRDRTFES 1381
R R R+ + RE ER KRR++ RE R L D +E+ +R R+R+R
Sbjct: 123 -RKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMRE 181
Query: 1382 SQIESVKRCEAKLEGEHERDLESTSRDSLA----LDKERMDK------------------ 1419
Q E ++ E + E R R+ A + ++ DK
Sbjct: 182 QQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERF 241
Query: 1420 DLGSVQGFEETNKSERTESL----EAGDDESKLDDAHSLGSGAGEGYEPISDDELDEILA 1475
+LG + + K E + L + D E K A S + +G G E ++E +E
Sbjct: 242 ELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEE 301
Query: 1476 GDAEKREDQQDEEK 1489
G + ++++EE+
Sbjct: 302 GSTSEESEEEEEEE 315
Score = 63.9 bits (154), Expect = 1e-09
Identities = 79/412 (19%), Positives = 164/412 (39%), Gaps = 65/412 (15%)
Query: 746 EKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE--- 802
EK+ + + E +E++R +E+E + E +R + D +R+ +RD ++ + RD E
Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSD-DRDSKRDSLEEGELRDHCMEITI 62
Query: 803 -----KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDK 857
+RE+ EDR D K ++ + R+ KR+ + ++
Sbjct: 63 RNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHER 122
Query: 858 NEKHRLLSQVVRP----QESRSLSPSHLTEDR--------QGRWKEEDRKPERKESSRRY 905
++HR R Q+ R ++ H +R + R ++ +RK ER+ R
Sbjct: 123 RKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQ 182
Query: 906 --EEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQ 963
E++E KE+ +++R++ E +++ HH++ + SD+ + ++ +
Sbjct: 183 QKEQREQKERERRAEERRKEREA-------RREVSAHHRTMREDYSDKVKASHWSRSPPR 235
Query: 964 -----------KKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKG 1012
+KP+K++K ++ + D Q S + + + + G
Sbjct: 236 PPRERFELGDGRKPVKEEKMEERDL--------LSDLQDISDSERKTSSAESSSAESGSG 287
Query: 1013 DSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDED- 1071
+ +EE ++ + + +EE E G N Q E+ + + S+++
Sbjct: 288 SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 347
Query: 1072 ---------VP------DRTEVTEAEHTATATTPGSTPSPLSSLLPPPPPVA 1108
VP D E EAE TP S+ +P P ++
Sbjct: 348 RENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALS 399
Score = 58.9 bits (141), Expect = 4e-08
Identities = 71/297 (23%), Positives = 120/297 (40%), Gaps = 42/297 (14%)
Query: 1195 NRSNRSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQL 1254
N R S R +DS Q RK +H ++ K K E++ ++
Sbjct: 64 NSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERR 123
Query: 1255 KRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ--ERDRYEHDRERE 1312
KR + + R++ R + E R+ G RDRL+ ER R + RE
Sbjct: 124 KRHREEQDKA--RREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMRE 181
Query: 1313 RERRDTRQREWDRDADKDWPRNRDRDRLRE-----------------------------R 1343
+++ Q+E +R A++ R ++R+ RE R
Sbjct: 182 QQKEQREQKERERRAEE---RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 238
Query: 1344 ERERERDKRRDLDRER--ER-LISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHER 1400
ER D R+ + E+ ER L+SD + + + ESS ES E + E E E
Sbjct: 239 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 298
Query: 1401 DLE-STSRDSLALDKERMDKDLGSVQGFEETNK--SERTESLEAGDDESKLDDAHSL 1454
+ E STS +S ++E +++ + EE ++ +E E +DE + ++ H L
Sbjct: 299 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLL 355
Score = 55.8 bits (133), Expect = 3e-07
Identities = 77/384 (20%), Positives = 131/384 (34%), Gaps = 48/384 (12%)
Query: 272 EDIALGKKYKEKYKVKDRIEE-KTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSR 330
++I KK +++ + K I+ K D +D RD + E RD + + S
Sbjct: 14 DEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSM 73
Query: 331 HHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPR 390
+I+ R+++ ++ R H R++
Sbjct: 74 EDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA 133
Query: 391 HRSPMREKGRH---DHERTSQSHD----------RRHERREDTRGKRDREKDSREEREYE 437
R R+K R +H R + +D + +RE R R+++K+ RE++E E
Sbjct: 134 RREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERE 193
Query: 438 QDQSSSRDHRDDREPRDGR-----------------DRRDARDTRDRRELRDSRD--MRD 478
+ R R+ R R R R+R EL D R +
Sbjct: 194 RRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEE 253
Query: 479 SREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREES 538
E RD D ++ D S+ ++ G + +E+ EE S EE
Sbjct: 254 KMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEE 313
Query: 539 SRTEIR-------NESRNESRSEIRNDRMGRSRGRVPE-----LPEKGSRGSRGSQIDSH 586
E E+ +S E+ + M R E +PE SR R S +S
Sbjct: 314 EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPE--SRFDRDSG-ESE 370
Query: 587 SSNSNYHDSWETRSSYPERDRYPE 610
+ + S+ E D P+
Sbjct: 371 EAEEEVGEGTPQSSALTEGDYVPD 394
Score = 54.3 bits (129), Expect = 9e-07
Identities = 66/287 (22%), Positives = 113/287 (39%), Gaps = 23/287 (8%)
Query: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND-SAHRSG-- 1218
R R+E++E + RK +Q++ R R+ + R + SAH
Sbjct: 163 RDRLEQLERKR-----ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 217
Query: 1219 DDQSGRKRVLH-SGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRR 1277
+D S + + H S S R + E+ G+ + + + K E R SD QD S S R+
Sbjct: 218 EDYSDKVKASHWSRSPPRPPRERFEL-GDGRKPVKEEKMEE--RDLLSDLQDI-SDSERK 273
Query: 1278 SSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR 1337
+S S SGS + +E + E + E + E + + +++ N +
Sbjct: 274 TSSAESSSAESGSGSEE-----EEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEE 328
Query: 1338 DRLRERERERERDKRRDLDRERER--LISDSVERDRDRDRDRTFESSQIESVKRCEAKLE 1395
+ E E + D +RE E L+ DRD E E + A E
Sbjct: 329 ASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTE 388
Query: 1396 GEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAG 1442
G++ D + S L K+ + K L ++QG + + +E G
Sbjct: 389 GDYVPDSPALSPIEL---KQELPKYLPALQGCRSVEEFQCLNRIEEG 432
Score = 43.5 bits (101), Expect = 0.002
Identities = 53/262 (20%), Positives = 104/262 (39%), Gaps = 18/262 (6%)
Query: 86 RERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWE 145
+E++ +++ + E + +E R+ R RHRE++D K +E + E
Sbjct: 94 KEKVHHRKDEKRKEKKHARVKEKE---REHERRKRHREEQD-KARREWERQKRREMAREH 149
Query: 146 TNRDDSDNGDINY-DYVHELSLEMKR-------QKIQRELMKLEQENMEKREEIIIKKEV 197
+ R+ ++G + D + +L + +R QK QRE + E+ E+R+E ++EV
Sbjct: 150 SRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 209
Query: 198 SP--EVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQ 255
S +R S S+SP R P+ RK V ++++ Q
Sbjct: 210 SAHHRTMREDYSDKVKASHWSRSPPR--PPRERFELGDGRK--PVKEEKMEERDLLSDLQ 265
Query: 256 SKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPR 315
R S + G + +E+ + ++ E T + + + E + E+
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSN 325
Query: 316 STSPAGQHHSPISSRHHSSSSQ 337
S + Q +S S +
Sbjct: 326 SEEASEQSAEEVSEEEMSEDEE 347
Score = 42.4 bits (98), Expect = 0.004
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 31/180 (17%)
Query: 71 SSNYRRSPERPT------GDLRERMKNKR----------QDVDTEPQKRNTEESSSPVRK 114
+S++ RSP RP GD R+ +K ++ QD+ +K ++ ESSS
Sbjct: 226 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 285
Query: 115 ESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQ 174
S E+E+ + + ESEEE E E +++ + E + E +++
Sbjct: 286 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNS-------EEASEQSAEEVS 338
Query: 175 RELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKD 234
E M E E E +++ V S+ + ++ + +P+SS+ ++ D
Sbjct: 339 EEEMS-EDEERENENHLLV-------VPESRFDRDSGESEEAEEEVGEGTPQSSALTEGD 390
>gi|52426743 cisplatin resistance-associated overexpressed protein
[Homo sapiens]
Length = 432
Score = 118 bits (295), Expect = 5e-26
Identities = 73/209 (34%), Positives = 116/209 (55%), Gaps = 12/209 (5%)
Query: 657 DERREERRVDRVDDRRDERARERDRERE-RDRERERERE-RERDREREKERELERERARE 714
+E +E+ R + RDER ++ +ERE R++ERERERE RER R RE+E E E+ERAR+
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEE-EREKERARD 286
Query: 715 REREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERER 774
RER R++ R R R R DR R R+ R + RER R R R+R R R +R +
Sbjct: 287 RER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRER---RRSRSRDRRRSRSHDRSERK 342
Query: 775 ERARERDKERERQRD---WEDKDKGRDDRREKREEIREDRNPRDGHDERK--SKKRYRNE 829
R+R RD+ R + RD ++ + K RD ++++ + +E R D K S+++ +
Sbjct: 343 HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSED 402
Query: 830 GSPSPRQSPKRRREHSPDSDAYNSGDDKN 858
+ ++S + + D + GD ++
Sbjct: 403 TNTESKESDTKNEVNGTSEDIKSEGDTQS 431
Score = 113 bits (283), Expect = 1e-24
Identities = 66/200 (33%), Positives = 108/200 (54%), Gaps = 24/200 (12%)
Query: 629 RDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRE 688
R R + +RD+R + ++ ER+ER +ER +R + R R E +RE+ER R+
Sbjct: 235 RKRTEEPDRDERL--------KKEKQEREEREKEREREREERERKRRREEEEREKERARD 286
Query: 689 RERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKE 748
RER R+R R R R R +R +R R+ +R + R+R R R RD R R +R
Sbjct: 287 RER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRS------ 339
Query: 749 REREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRRE-----K 803
ER+ R R R+R R + R+R+ + R++ RD+E++R+ ++K +G DD++
Sbjct: 340 ---ERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEK-RGSDDKKSSVKSGS 395
Query: 804 REEIREDRNPRDGHDERKSK 823
RE+ ED N + K++
Sbjct: 396 REKQSEDTNTESKESDTKNE 415
Score = 110 bits (275), Expect = 1e-23
Identities = 73/202 (36%), Positives = 109/202 (53%), Gaps = 20/202 (9%)
Query: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724
V+ + ++ +R E DR+ +E++ ERE++RERE+E ERER R RE E E+E++
Sbjct: 227 VEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERERE---ERERKRRRE-EEEREKE 282
Query: 725 RERDRDRDHDRERERERERDREKERERERE-ERERERERERERERERERERERARERDKE 783
R RDR+R R+R R R R R +R R R+ +R R RER R R R+R R R +
Sbjct: 283 RARDRER-----RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD 337
Query: 784 RERQRDWEDKDKGRDDRREK---REEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPK- 839
R ++ + + RD RR K R+ + RD +RKSK++ GS + S K
Sbjct: 338 RSERK---HRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEK-EKRGSDDKKSSVKS 393
Query: 840 -RRREHSPDSDAYN-SGDDKNE 859
R + S D++ + D KNE
Sbjct: 394 GSREKQSEDTNTESKESDTKNE 415
Score = 103 bits (256), Expect = 2e-21
Identities = 68/226 (30%), Positives = 108/226 (47%), Gaps = 15/226 (6%)
Query: 577 GSRGSQIDSHSSNSNYHDSWETRSSYPE-------RDRYPERDNRDQARDSSFERRHGER 629
G S++D H + + +++ E R P+RD R + E R ER
Sbjct: 202 GDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKER 261
Query: 630 DR-RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRE 688
+R R+ RER +R R + R + ER +R R R R +R R R+ +R R
Sbjct: 262 EREREERERKRRREEEEREKERARDRERRKRSRSR--SRHSSRTSDRRCSRSRDHKRSRS 319
Query: 689 RERERERERDREREK--ERELERERAREREREREKERDRERDRDRDHDRERERERERDRE 746
RER R R RDR R + +R + R+R R+R R K RDR+ + R R+RE++R +
Sbjct: 320 RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDR---KS 376
Query: 747 KEREREREERERERERERERERERERERERARERDKERERQRDWED 792
KE+E+ + ++ + RE++ E ++E D + E ED
Sbjct: 377 KEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSED 422
Score = 101 bits (252), Expect = 5e-21
Identities = 67/205 (32%), Positives = 102/205 (49%), Gaps = 12/205 (5%)
Query: 716 EREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER-ERERERERERER 774
E +EK R R + DRD ++E++ +REKEREREREERER+R R E ERE+ER R+R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDR 287
Query: 775 ERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSP 834
ER R+R + R R + R KR RE R R D R+S+ R+E
Sbjct: 288 ER-RKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSR-SRDRRRSRSHDRSE----- 340
Query: 835 RQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDR 894
++ R S D S D K+ KHR S+ ++D++ K R
Sbjct: 341 ----RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSR 396
Query: 895 KPERKESSRRYEEQELKEKVSSVDK 919
+ + ++++ +E + K +V+ +
Sbjct: 397 EKQSEDTNTESKESDTKNEVNGTSE 421
Score = 97.1 bits (240), Expect = 1e-19
Identities = 69/214 (32%), Positives = 103/214 (48%), Gaps = 19/214 (8%)
Query: 707 LERERAREREREREKERDRERDRDRDHDRERERERERDR-EKEREREREERERERERERE 765
+E + + R+R E +RD +++ ERE+ERER+R E+ER+R REE ERE+ER R+
Sbjct: 227 VEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARD 286
Query: 766 RERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKR 825
RER R+R R R+R + +R R +D R RE+R DR HD + K R
Sbjct: 287 RER-RKRSRSRSRHSSRTSDR-RCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHR 344
Query: 826 YRNEGSPSPRQSPKRRREHSPDSDAY---NSGDDKNEKHRLLSQVVRPQESRSLSPSHLT 882
R S RRR S D +Y + D+ + + + R + + S +
Sbjct: 345 SR---------SRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGS 395
Query: 883 EDRQGRWKEEDRKPERKESSRRYEEQELKEKVSS 916
++Q ED E KES + E E + S
Sbjct: 396 REKQ----SEDTNTESKESDTKNEVNGTSEDIKS 425
Score = 91.7 bits (226), Expect = 5e-18
Identities = 108/418 (25%), Positives = 173/418 (41%), Gaps = 67/418 (16%)
Query: 544 RNESRNESRSEIRNDRMGRSR----GRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETR 599
RN + +E RS +R D + G P +R G H N R
Sbjct: 16 RNLAPDEKRSNVRWDHESVCKYYLCGFCPAELFTNTRSDLGPCEKIHDEN--------LR 67
Query: 600 SSYPERDRYP----ERD--NRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE 653
Y + R+ ERD Q+ + ERR R ++Q+ S G+N+E
Sbjct: 68 KQYEKSSRFMKVGYERDFLRYLQSLLAEVERRIRRGHARLALSQNQQSSGAAGPTGKNEE 127
Query: 654 LERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAR 713
++ + D+ D ++ + + E + + + ++EREL R
Sbjct: 128 ----------KIQVLTDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQLKEERELLRSTTS 177
Query: 714 EREREREKERDRE--------------RDRDRDHDRER------------ERERERDREK 747
E +E+ E + R DH + E +E+ R++
Sbjct: 178 TIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKR 237
Query: 748 EREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
E +R+ER ++ ++ERE ERE+ERERER ER+++R R+ + +K++ RD R KR
Sbjct: 238 TEEPDRDERLKKEKQERE-EREKERERER-EERERKRRREEEEREKERARDRERRKRS-- 293
Query: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867
R H R S +R +S +RRR S D S D KHR S+
Sbjct: 294 ----RSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRSRD 349
Query: 868 VRPQESRS-LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQT 924
R +SR S H ++ R +E+DRK + KE R ++++ K S +KQ E T
Sbjct: 350 RRRSKSRDRKSYKHRSKSRD---REQDRKSKEKE-KRGSDDKKSSVKSGSREKQSEDT 403
Score = 72.8 bits (177), Expect = 2e-12
Identities = 60/235 (25%), Positives = 99/235 (42%), Gaps = 29/235 (12%)
Query: 1243 ITGERKSRIDQLKRGEP----SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDR 1298
I G+ +SR+D G+ ++ ++ + R P+ D ++ + R++
Sbjct: 200 IVGDAQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREK 259
Query: 1299 LQERDRYEHDRERERE----------------RRDTRQREWDRDADKDWPRNRD--RDRL 1340
+ER+R E +R+R RE R +R R R +D+ R+RD R R
Sbjct: 260 EREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS 319
Query: 1341 RERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHER 1400
RER R R RD+RR +R S RDR R + R +S + S R + E+
Sbjct: 320 RERRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSR-------DREQ 372
Query: 1401 DLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLG 1455
D +S ++ D ++ GS + E +E ES + +D S G
Sbjct: 373 DRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEG 427
Score = 72.4 bits (176), Expect = 3e-12
Identities = 39/160 (24%), Positives = 75/160 (46%)
Query: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREER 663
+R R E +++ARD +R R R +R D+R S H+ R R +R
Sbjct: 271 KRRREEEEREKERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDR 330
Query: 664 RVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKER 723
R R DR + + R R R+R R + R+R+ + R + R++E++ + + +R + +K
Sbjct: 331 RRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
Query: 724 DRERDRDRDHDRERERERERDREKEREREREERERERERE 763
+ R++ + +E D + E E+ + E + +
Sbjct: 391 VKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQ 430
Score = 66.6 bits (161), Expect = 2e-10
Identities = 59/228 (25%), Positives = 92/228 (40%), Gaps = 20/228 (8%)
Query: 1215 HRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHS 1274
H G G ++ + +EK + +R R+ + K+ R +R+
Sbjct: 211 HLMGKQHMGYAKIKATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERER 270
Query: 1275 SRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN 1334
RR E + +R D R + R R H R +RR +R R+ R ++ R+
Sbjct: 271 KRRREEEEREKERAR----DRERRKRSRSRSRHS-SRTSDRRCSRSRDHKRSRSRERRRS 325
Query: 1335 RDRDRL--R------ERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIES 1386
R RDR R + R R RD+RR R+R+ S RDR++DR + +
Sbjct: 326 RSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385
Query: 1387 VKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSE 1434
K+ K G E+ E T+ +S D + V G E KSE
Sbjct: 386 DKKSSVK-SGSREKQSEDTNTESKESDTK------NEVNGTSEDIKSE 426
Score = 64.3 bits (155), Expect = 9e-10
Identities = 57/195 (29%), Positives = 88/195 (45%), Gaps = 18/195 (9%)
Query: 412 RRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELR 471
R+ D + +EK REERE E+++ +RE R+ + RR+ + RE
Sbjct: 235 RKRTEEPDRDERLKKEKQEREEREKERER--------EREERERKRRRE----EEEREKE 282
Query: 472 DSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGR 531
+RD + R SR + + D R SRS RD R RE R + ++ SRS+ R
Sbjct: 283 RARDRERRKRSRSRSRHSSRTSDRRCSRS-RDHKRSRSRERRRSRSRD---RRRSRSHDR 338
Query: 532 NHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSN 591
+ R+ SR+ R S++ R ++ R R + + EK RGS + S S S
Sbjct: 339 SE-RKHRSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKK-SSVKSGSR 396
Query: 592 YHDSWETRSSYPERD 606
S +T + E D
Sbjct: 397 EKQSEDTNTESKESD 411
Score = 62.8 bits (151), Expect = 3e-09
Identities = 50/184 (27%), Positives = 85/184 (46%), Gaps = 14/184 (7%)
Query: 383 QRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDS---REEREYEQD 439
+R + P R +EK + + +R R+ R + +REK+ RE R+ +
Sbjct: 236 KRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRS 295
Query: 440 QSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDS-------REMRDYSRDTKES 492
+S DR RD + +R +R+RR R SRD R S R+ R SRD + S
Sbjct: 296 RSRHSSRTSDRRCSRSRDHKRSR-SRERRRSR-SRDRRRSRSHDRSERKHRSRSRDRRRS 353
Query: 493 RDPRDSRSTRDAHDYRDRE-GRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNES 551
+ RD +S + RDRE R + KE ++ +S ++ RE+ S +++
Sbjct: 354 KS-RDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDT 412
Query: 552 RSEI 555
++E+
Sbjct: 413 KNEV 416
Score = 62.4 bits (150), Expect = 3e-09
Identities = 51/218 (23%), Positives = 91/218 (41%), Gaps = 34/218 (15%)
Query: 281 KEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGS 340
KEK + ++R +E+ R+ ++R R R+ E+R+K R+ + S SRH S +S
Sbjct: 249 KEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRSRHSSRTSD--- 305
Query: 341 SIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGR 400
+R S S KR+ S +R++S R R R R
Sbjct: 306 --RRCSRSRDHKRS-------------------------RSRERRRSRSRDRRRSRSHDR 338
Query: 401 HDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRD 460
+ + S+S DRR + D + + R K R+ EQD+ S + + + +
Sbjct: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSKS----RDREQDRKSKEKEKRGSDDKKSSVKSG 394
Query: 461 ARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDS 498
+R+ + +S++ E+ S D K D + +
Sbjct: 395 SREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQSN 432
Score = 61.6 bits (148), Expect = 6e-09
Identities = 53/190 (27%), Positives = 73/190 (38%), Gaps = 17/190 (8%)
Query: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572
RD K++ E R R REE R R E E +R RSR R
Sbjct: 243 RDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSR------ 296
Query: 573 KGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRR 632
SR S D S S H RS ER R RD R ER+H R R
Sbjct: 297 -SRHSSRTS--DRRCSRSRDHK----RSRSRERRRSRSRDRRRSRSHDRSERKHRSRSR- 348
Query: 633 DNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERE 692
D R R +H+ ++ + E+D + +E+ DD+ ++ + RE+ E
Sbjct: 349 DRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDK---KSSVKSGSREKQSEDTNT 405
Query: 693 RERERDRERE 702
+E D + E
Sbjct: 406 ESKESDTKNE 415
Score = 57.8 bits (138), Expect = 8e-08
Identities = 53/203 (26%), Positives = 88/203 (43%), Gaps = 22/203 (10%)
Query: 395 MREKGRHDHERTSQSHDRRHER--REDTRGKRDREKDSREEREYEQDQSSSRDHRDDREP 452
++EK R E + + E+ RE+ +R+RE++ RE + +++ ++ DRE
Sbjct: 230 LKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRER 289
Query: 453 RDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREG 512
R R R +R + + R SR RD + R R SRD R SRS HD +R+
Sbjct: 290 RK-RSRSRSRHSSRTSDRRCSRS-RDHKRSRSRERRRSRSRDRRRSRS----HDRSERKH 343
Query: 513 RDTHRKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPE 572
R R + RS R+ R ++ S++ R + R + RG +
Sbjct: 344 RSRSR------DRRRSKSRD-------RKSYKHRSKSRDREQDRKSKEKEKRGS-DDKKS 389
Query: 573 KGSRGSRGSQIDSHSSNSNYHDS 595
GSR Q + ++ S D+
Sbjct: 390 SVKSGSREKQSEDTNTESKESDT 412
Score = 55.5 bits (132), Expect = 4e-07
Identities = 58/248 (23%), Positives = 91/248 (36%), Gaps = 51/248 (20%)
Query: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSI 342
K K++ R EE RD +R + +++RE+R+K R
Sbjct: 231 KEKLRKRTEEPDRD--ERLKKEKQEREEREKER--------------------------- 261
Query: 343 QRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHD 402
+R RKR RR +R++ R RS R R
Sbjct: 262 EREREERERKR--------------RREEEEREKERARDRERRK---RSRSRSRHSSRTS 304
Query: 403 HERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDAR 462
R S+S D + R + R R R +D R R +++ + R DR RDR+ +
Sbjct: 305 DRRCSRSRDHKRSRSRERR--RSRSRDRRRSRSHDRSERKHRSRSRDRRRSKSRDRKSYK 362
Query: 463 DTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTY 522
R + RD R S+E D K+S SR + + + DT + +
Sbjct: 363 H---RSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGT 419
Query: 523 PEESRSYG 530
E+ +S G
Sbjct: 420 SEDIKSEG 427
Score = 55.1 bits (131), Expect = 5e-07
Identities = 50/213 (23%), Positives = 90/213 (42%), Gaps = 23/213 (10%)
Query: 428 KDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSR 487
K + EE + + + + RD+R ++ ++R + R+R R+ R+ + RE + +
Sbjct: 224 KATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKERERE--REERERKRRREEEEREK 281
Query: 488 DTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSRTEIRNES 547
+ R+ R +R H + R D SR + R+ RE R R+
Sbjct: 282 ERARDRERRKRSRSRSRH---------SSRTSDRRCSRSRDHKRSRSRE---RRRSRSRD 329
Query: 548 RNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRSSYPERDR 607
R SRS R++R RSR R R S+ S+ S D + R S E+++
Sbjct: 330 RRRSRSHDRSERKHRSRSR-------DRRRSKSRDRKSYKHRSKSRDREQDRKS-KEKEK 381
Query: 608 YPERDNRDQARDSSFERRHGERDRRDNRERDQR 640
D + + S E++ E +++E D +
Sbjct: 382 RGSDDKKSSVKSGSREKQ-SEDTNTESKESDTK 413
Score = 53.5 bits (127), Expect = 2e-06
Identities = 53/214 (24%), Positives = 95/214 (44%), Gaps = 31/214 (14%)
Query: 779 ERDKERERQRDWE-DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQS 837
E KE+ R+R E D+D+ +++REE RE R+ +ER+ K+R E R
Sbjct: 228 EELKEKLRKRTEEPDRDERLKKEKQEREE-REKERERE-REERERKRRREEEEREKERAR 285
Query: 838 PKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPE 897
+ RR+ S ++S R SR S E R+ R ++ R
Sbjct: 286 DRERRKRSRSRSRHSSRTSDR----------RCSRSRDHKRSRSRERRRSRSRDRRR--- 332
Query: 898 RKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENK 957
SR ++ E K + S D++R ++ +S + R+ +S DRE ++ ++ K
Sbjct: 333 ----SRSHDRSERKHRSRSRDRRRSKSRDRKSYKHRS-------KSRDREQDRKSKEKEK 381
Query: 958 KKAKIQKKPIK----KKKEDDVGIERGNIETTSE 987
+ + +K +K +K+ +D E +T +E
Sbjct: 382 RGSDDKKSSVKSGSREKQSEDTNTESKESDTKNE 415
Score = 49.7 bits (117), Expect = 2e-05
Identities = 53/218 (24%), Positives = 94/218 (43%), Gaps = 34/218 (15%)
Query: 860 KHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDK 919
K +L + P L ++R+ R KE +R+ E +E RR EE+E +EK + D+
Sbjct: 231 KEKLRKRTEEPDRDERLKKEK--QEREEREKEREREREERERKRRREEEE-REKERARDR 287
Query: 920 QREQTEILES------SRMRAQDIIGHHQSEDRETS---------DRAHDENKKKAKIQK 964
+R + S S R H +S RE R+HD +++K + +
Sbjct: 288 ERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKHRSRS 347
Query: 965 KPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQ 1024
+ ++ K D R + + S+ S + Q +KS K K+ +G SD++ +
Sbjct: 348 RDRRRSKSRD----RKSYKHRSK-----SRDREQDRKS---KEKEKRG----SDDKKSSV 391
Query: 1025 SKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDT 1062
R ++ T+ + + N NG ED + + DT
Sbjct: 392 KSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDT 429
Score = 49.7 bits (117), Expect = 2e-05
Identities = 52/205 (25%), Positives = 85/205 (41%), Gaps = 30/205 (14%)
Query: 1162 RTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQ 1221
R R E+ + ++ Q R+ +++R R R R R+ D
Sbjct: 235 RKRTEEPDRDERLKKEKQEREEREKERE------REREERERKRRREEEEREKERARD-- 286
Query: 1222 SGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPE 1281
R+R S SR R +++ + R + + E RS S DR+ SRSH
Sbjct: 287 --RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHD------R 338
Query: 1282 SDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRD----- 1336
S+R+ SR SRDR + + R DR+ + R +R RE DR + + R D
Sbjct: 339 SERKHRSR-----SRDRRRSKSR---DRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSS 390
Query: 1337 -RDRLRERERERERDKRRDLDRERE 1360
+ RE++ E + ++ D + E
Sbjct: 391 VKSGSREKQSEDTNTESKESDTKNE 415
Score = 48.5 bits (114), Expect = 5e-05
Identities = 49/190 (25%), Positives = 81/190 (42%), Gaps = 21/190 (11%)
Query: 75 RRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERT 134
R+ E P D ER+K ++Q+ + ++R E R+E R R RE+E+ + KER
Sbjct: 235 RKRTEEPDRD--ERLKKEKQEREEREKERERE------REERERKRRREEEERE--KERA 284
Query: 135 PESEEENVEWETNRDDSDNGDI----NYDYVHELSLEMKRQKIQRELMKLEQENMEKREE 190
+ E +R S D + D+ S E +R + + + E++
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSERKH- 343
Query: 191 IIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKK--DRKTSAVSSPLLDQQ 248
+ S + RSK S + SKS R+ KS K+ D K S+V S ++Q
Sbjct: 344 ----RSRSRDRRRSKSRDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQ 399
Query: 249 RNSKTNQSKK 258
+SK+
Sbjct: 400 SEDTNTESKE 409
Score = 45.8 bits (107), Expect = 3e-04
Identities = 46/177 (25%), Positives = 71/177 (40%), Gaps = 40/177 (22%)
Query: 1154 EDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSN-----------RSHT 1202
E+ RK R E+ + E A+ R+ + RS S S+R++ RS +
Sbjct: 266 EERERKRRREEEEREK------ERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRS 319
Query: 1203 SGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRS 1262
R RS S D D+S RK S SRDR ++KS + ++ RS
Sbjct: 320 RERRRSRSRDRRRSRSHDRSERKH--RSRSRDRRRSKSRD------------RKSYKHRS 365
Query: 1263 TSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTR 1319
S DR+ R + D++ +SGS R++ D E + DT+
Sbjct: 366 KSRDREQDRKSKEKEKRGSDDKKSSVKSGS---------REKQSEDTNTESKESDTK 413
Score = 42.4 bits (98), Expect = 0.004
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 38/230 (16%)
Query: 120 RHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMK 179
+H IK T E E + E E +RD+ + + E + ++ +RE +
Sbjct: 216 QHMGYAKIKATVEELKEKLRKRTE-EPDRDER---------LKKEKQEREEREKERERER 265
Query: 180 LEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSA 239
E+E +REE +KE + + R K S S S R SS++ R+ S S K+ R
Sbjct: 266 EERERKRRREEEEREKERARDRERRKRSRSRS-RHSSRTSDRRCS--RSRDHKRSRSRER 322
Query: 240 VSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKD 299
S D++R+ ++S++ K + + +DR K+RD K
Sbjct: 323 RRSRSRDRRRSRSHDRSER----------------------KHRSRSRDRRRSKSRDRKS 360
Query: 300 ---RGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHS 346
R + +R+++++ K + + S + S S+ ++ + S
Sbjct: 361 YKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNTESKES 410
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.125 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,168,307
Number of Sequences: 37866
Number of extensions: 3971356
Number of successful extensions: 158731
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1327
Number of HSP's successfully gapped in prelim test: 1501
Number of HSP's that attempted gapping in prelim test: 30387
Number of HSP's gapped (non-prelim): 43739
length of query: 1564
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1448
effective length of database: 13,855,062
effective search space: 20062129776
effective search space used: 20062129776
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.