Search of human proteins with 115648142

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|115648142 centrosomal protein 164kDa [Homo sapiens]
         (1460 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|115648142 centrosomal protein 164kDa [Homo sapiens]               2853   0.0  
gi|148746195 trichohyalin [Homo sapiens]                              150   1e-35
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                       134   5e-31
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                       134   5e-31
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                        134   5e-31
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                        134   5e-31
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                        134   5e-31
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                        134   5e-31
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                        134   5e-31
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                        134   5e-31
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ...   130   7e-30
gi|21735548 centrosomal protein 2 [Homo sapiens]                      130   1e-29
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...   127   8e-29
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...   127   8e-29
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...   127   8e-29
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...   127   8e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]    125   2e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]   125   4e-28
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...   122   3e-27
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...   121   4e-27
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...   121   6e-27
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]        120   7e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]    120   1e-26
gi|88196790 coiled-coil domain containing 88 [Homo sapiens]           119   3e-26
gi|42794779 myosin 18A isoform b [Homo sapiens]                       118   4e-26
gi|28416946 myosin 18A isoform a [Homo sapiens]                       118   4e-26
gi|16262452 cingulin [Homo sapiens]                                   118   5e-26
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...   117   1e-25
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]          115   3e-25
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]          115   3e-25

>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
          Length = 1460

 Score = 2853 bits (7396), Expect = 0.0
 Identities = 1460/1460 (100%), Positives = 1460/1460 (100%)

Query: 1    MAGRPLRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPIKEPELMWLAREGIVAPLPG 60
            MAGRPLRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPIKEPELMWLAREGIVAPLPG
Sbjct: 1    MAGRPLRIGDQLVLEEDYDETYIPSEQEILEFAREIGIDPIKEPELMWLAREGIVAPLPG 60

Query: 61   EWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAKLSTSGAIKKKKKKKEKKD 120
            EWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAKLSTSGAIKKKKKKKEKKD
Sbjct: 61   EWKPCQDITGDIYYFNFANGQSMWDHPCDEHYRSLVIQERAKLSTSGAIKKKKKKKEKKD 120

Query: 121  KKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLG 180
            KKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLG
Sbjct: 121  KKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLG 180

Query: 181  ELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRN 240
            ELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRN
Sbjct: 181  ELMLPSQGLKTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRN 240

Query: 241  LHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKG 300
            LHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKG
Sbjct: 241  LHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKG 300

Query: 301  RQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSR 360
            RQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSR
Sbjct: 301  RQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSR 360

Query: 361  REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRIS 420
            REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRIS
Sbjct: 361  REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRIS 420

Query: 421  EHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEER 480
            EHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEER
Sbjct: 421  EHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEER 480

Query: 481  AQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGK 540
            AQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGK
Sbjct: 481  AQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGK 540

Query: 541  EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA 600
            EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA
Sbjct: 541  EQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA 600

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA
Sbjct: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQ 720
            RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQ
Sbjct: 661  RMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQ 720

Query: 721  MLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSS 780
            MLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSS
Sbjct: 721  MLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSS 780

Query: 781  LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKR 840
            LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKR
Sbjct: 781  LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKR 840

Query: 841  QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE 900
            QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE
Sbjct: 841  QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE 900

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL 960
            TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL
Sbjct: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLL 960

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
            DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA
Sbjct: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020

Query: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080
            QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS
Sbjct: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080

Query: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140
            SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH
Sbjct: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140

Query: 1141 ELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1200
            ELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL
Sbjct: 1141 ELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1200

Query: 1201 WEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRK 1260
            WEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRK
Sbjct: 1201 WEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSRK 1260

Query: 1261 IHGLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLAR 1320
            IHGLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLAR
Sbjct: 1261 IHGLSHSLRQISSQLSSVLSILDSLNPQSPPPLLASMPAQLPPRDPKSTPTPTYYGSLAR 1320

Query: 1321 FSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPLES 1380
            FSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPLES
Sbjct: 1321 FSALSSATPTSTQWAWDSGQGPRLPSSVAQTVDDFLLEKWRKYFPSGIPLLSNSPTPLES 1380

Query: 1381 RLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKA 1440
            RLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKA
Sbjct: 1381 RLGYMSASEQLRLLQHSHSQVPEAGSTTFQGIIEANRRWLERVKNDPRLPLFSSTPKPKA 1440

Query: 1441 TLSLLQLGLDEHNRVKVYRF 1460
            TLSLLQLGLDEHNRVKVYRF
Sbjct: 1441 TLSLLQLGLDEHNRVKVYRF 1460


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  150 bits (378), Expect = 1e-35
 Identities = 182/748 (24%), Positives = 326/748 (43%), Gaps = 96/748 (12%)

Query: 457  DELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAA 516
            DE +  +  G E  L      E++ +  PR    EEEP Q    Q   ++  EL E    
Sbjct: 96   DEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQ-RRRQKRQEQERELAEGEEQ 154

Query: 517  SLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVR 576
            S   +   QR              ++  + EEL   ++E ++ EE+ A       S +  
Sbjct: 155  SEKQERLEQR--------------DRQRRDEELWRQRQEWQEREERRA-EEEQLQSCKGH 199

Query: 577  STEPVAPPEQLSEAAL-----KAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEE 631
             TE     EQL    L     K  EE   Q  E+  R + + ++EK  + RE + ++EEE
Sbjct: 200  ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR-VFQEEEEKEWRKRETVLRKEEE 258

Query: 632  EILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAE 691
            ++     Q+++ L    E+L+K   +E  R R+EE Q+   LR          E Q+R +
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR---------EQQLRRK 309

Query: 692  QEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQL 751
            QE   ++ +EE   QQ+      E++ +Q+  + +E  E   + EQ      +E+  QQL
Sbjct: 310  QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ-----EEERREQQL 364

Query: 752  REQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCL 811
            R + E ER+E     E++   E ++L    + +  + +   Q+  +E Q + E QL++  
Sbjct: 365  RREQEEERREQQLRREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRR-- 421

Query: 812  GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA 871
             Q   R  ++  H   +E E       + Q ++ E E R D +K E +       E++E 
Sbjct: 422  EQQLRREQEEERHEQKHEQE------RREQRLKREQEERRDWLKREEE------TERHEQ 469

Query: 872  EERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRR---RHREQERKLQDLE 928
            E RKQ+ +       E ER +R  + E E  R++Q +R + LRR     REQ  K Q+ E
Sbjct: 470  ERRKQQLK----RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525

Query: 929  LDLETRAK-DVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH 987
              L+ R + + + R    E +E+  +RE+++ L+ +R+      E      QL + ++E 
Sbjct: 526  ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE- 584

Query: 988  THLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVT 1047
                +  Q+L+   +E   ++LK E +V+ L+ Q ++ ++     E E +++Q LL+   
Sbjct: 585  ----RRQQRLKREQEERLEQRLKRE-EVERLE-QEERREQRLKREEPEEERRQQLLKSEE 638

Query: 1048 VEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEG 1107
             EE                ++ L   Q +     L + +E+  L+          L  E 
Sbjct: 639  QEERR--------------QQQLRREQQERREQRLKREEEEERLE--------QRLKREH 676

Query: 1108 VALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEK 1167
               R  +E   ++    R R   +K+    W+ +L S  +  +     K     RK  E 
Sbjct: 677  EEERREQELAEEEQEQARER---IKSRIPKWQWQLESEADARQS----KVYSRPRKQ-EG 728

Query: 1168 ETRHLDEMKSAMRKGHNLLKKKEEKLNQ 1195
            + R  ++ +   R+   L  ++EE+ ++
Sbjct: 729  QRRRQEQEEKRRRRESELQWQEEERAHR 756



 Score =  141 bits (355), Expect = 5e-33
 Identities = 186/809 (22%), Positives = 346/809 (42%), Gaps = 95/809 (11%)

Query: 467  LEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEW-KEAEELGEDSAASLSLQLSLQ 525
            L E+    L  EER Q   R L  EEE  Q    + E  KE + L E+       +    
Sbjct: 790  LREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQL 849

Query: 526  REQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPE 585
            +E+        E+ + Q  + ++    Q E E    +  +   P +  ++R  + +   E
Sbjct: 850  QEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEE 909

Query: 586  QLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLS 645
            +              + L++++R     ++++ Q   E+  Q+EEE++LR  ++K +   
Sbjct: 910  E--------------EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE 955

Query: 646  SLRE-RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELE 704
              R+ R  K ++++E ++  EE ++    R Q +     +E++++ E+E  L++ RE+  
Sbjct: 956  RERQYRKDKKLQQKEEQLLGEEPEKR---RRQEREKKYREEEELQQEEEQLLREEREKRR 1012

Query: 705  SQ----QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERK 760
             Q    Q  ++  L+Q+  Q+L + +E+    E+  Q      +E+ LQQ  EQL GE +
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYR----EEEELQQEEEQLLGEER 1068

Query: 761  EAVAT--LEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRV 818
            E      LE+++  E E L    E   RE     +++ +E Q +EE +LQ+         
Sbjct: 1069 ETRRRQELERQYRKE-EELQQEEEQLLREEPEKRRRQERERQCREEEELQQ--------- 1118

Query: 819  HQKSYHVAGYEHELSSLLREKRQEVEGEHE-RRLDKMKEEHQQVMAKAREQYEAEERKQR 877
                      E +L    REKR+  E E + R  +++++E +Q++ +  E+   +E +++
Sbjct: 1119 ---------EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQ 1169

Query: 878  AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
                  L  E E+L R  + +    R+ Q++  E+L+R+ R+Q  + +D   DL+ +   
Sbjct: 1170 YREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQ--- 1226

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 997
                    E ++E A R+         +V  K  E     +QLE++Q       QS Q L
Sbjct: 1227 -------WEPEKENAVRD--------NKVYCKGRE-NEQFRQLEDSQLRDR---QSQQDL 1267

Query: 998  REILDELQARKLKLE----SQVDLLQAQSQQL----QKHFSSLEAEAQKKQHLLREVTVE 1049
            + +L E Q R  + E     Q D    + +QL    QK     + ++Q+++ LLRE   E
Sbjct: 1268 QHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREE 1327

Query: 1050 ENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVW--HLLSAEG 1107
            +       E D    +  + L   Q +E      Q ++  + +    H       L  E 
Sbjct: 1328 KRRRQ---ETDRKFREEEQLL---QEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQ 1381

Query: 1108 VALRSAKE--FL--VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRK 1163
               R  +E  FL   QQ R   R Q   +   + +R E        +D    +  + +R+
Sbjct: 1382 RLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRR 1441

Query: 1164 NLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL-ESSLWEEASDEGTLGGSPTKKAVTFD 1222
              E+E + L+E +   ++ H   +++E+ L +  E  L  +  D   L      +    D
Sbjct: 1442 Q-ERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERD 1500

Query: 1223 --LSDMDSLSSESSESFSPPHREWWRQQR 1249
                + +  S E    F    ++  RQQR
Sbjct: 1501 RKFREQELRSQEPERKFLEEEQQLHRQQR 1529



 Score =  131 bits (330), Expect = 4e-30
 Identities = 174/786 (22%), Positives = 334/786 (42%), Gaps = 64/786 (8%)

Query: 449  KDDSQSSQDEL--QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
            KD+ Q  +++L  + ++ + L+ER       EE  Q   + L  E E  +  E + ++++
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRK 1082

Query: 507  AEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS 566
             EEL ++    L  +   +R Q       C + +E   + E+L     E  +   +  + 
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERE--RQCREEEELQQEEEQL---LREEREKRRRQELE 1137

Query: 567  PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQV--LEQDQRHLLESKQEKMQQLREK 624
                   EV+  E     E+  +   + +E    +   L+Q++  LL  +QEK +Q RE+
Sbjct: 1138 RQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197

Query: 625  LCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 684
              +EEEE      Q+++Q      +R     + E  +       ++     + +   Q +
Sbjct: 1198 QYREEEE---LQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLE 1254

Query: 685  EDQIRAEQ-EASLQKLR-EELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA 742
            + Q+R  Q +  LQ L  E+ E  ++ ER   +Q++R   E+  E++E  E+ E    + 
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE--EQLEREEQKEAKRRDR 1312

Query: 743  AKEKALQQLREQLEGERK--EAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQ 800
              ++  Q LRE+ E +R+  E      +E     ER    L  + R+      +K +E +
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERD------RKFREEE 1366

Query: 801  QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQ 860
             + + Q +K L + E R+ ++       + E     +E+ Q++  + +R   K +EE QQ
Sbjct: 1367 LRHQEQGRKFLEE-EQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR---KFREEEQQ 1422

Query: 861  VMAKAREQYEAEERKQ--RAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHR 918
            +  + R++   EE +Q  R E       E ++L++   R+     Q   +R E+ +   +
Sbjct: 1423 LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER-EEQQLHRQ 1481

Query: 919  EQERKLQDLELDLETRAKDVKARLALLEVQEETAR--REKQQLLDVQRQVALKSEEATAT 976
            E++RK  + E  L  + +D K R   L  QE   +   E+QQL   QRQ     EE    
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 977  HQQL-EEAQKEHTHLLQSNQQLREILDELQA------RKLKLESQVDLLQAQSQQLQKHF 1029
             Q+  ++ +++     +  +QLR+  +E Q       RK +LE Q    Q Q ++  +  
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 1030 SSL---EAEAQKKQHLLREVTVEENNASPHFEPDLHIED-----------LRKSLGTNQT 1075
              L   E + Q +Q   R+   +E       E  LH ++           LR+     Q 
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQL 1661

Query: 1076 KEVSSSLSQSKEDLYLDS----LSSHNVWHLLSAEGVALRSA---KEFLVQQTRSMRRRQ 1128
            +       + +E L  +     L           E   LR     ++FL Q+ + +RR++
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL-QEEQQLRRQE 1720

Query: 1129 TALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHL--DEMKSAMRKGHNLL 1186
               K  ++    +    +++ +     K LE+ +   E+E + L   E     R+   L 
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780

Query: 1187 KKKEEK 1192
            +++EE+
Sbjct: 1781 QEREEQ 1786



 Score =  131 bits (329), Expect = 5e-30
 Identities = 209/928 (22%), Positives = 387/928 (41%), Gaps = 137/928 (14%)

Query: 331  KADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISE 390
            K D    E  +   +E  +  +   E   R EE  ++ +++    EE  +   QELE  +
Sbjct: 1022 KKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLG-EERETRRRQELE-RQ 1079

Query: 391  HMKEPQLSDS----IASDPKSFHGLDFGFRSRISEHLLDVD--VLSPVLGGACRQAQQPL 444
            + KE +L       +  +P+     +   + R  E L   +  +L        RQ  +  
Sbjct: 1080 YRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQ 1139

Query: 445  GIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEW 504
              E+++  Q  +  L+ +  K   + L      EE  Q     L  EE+  +  E + ++
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199

Query: 505  KEAEEL----------GEDSAASLSLQLSLQREQAPSPPAACEKGKE--QHSQAEE---- 548
            +E EEL           ED  + L  Q   ++E A        KG+E  Q  Q E+    
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLR 1259

Query: 549  -----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEE 597
                       LG  Q+E +  +E+          PE    E     E+  EA  +  + 
Sbjct: 1260 DRQSQQDLQHLLGE-QQERDREQERRRWQQRDRHFPEEEQLER----EEQKEAKRRDRKS 1314

Query: 598  AVAQVLEQDQRHLLESKQEKMQQLREK--LCQEEEEEILRLHQQ----KEQSLSSLRERL 651
               + L +++R     +QE  ++ RE+  L QE EE+ LR  ++    +E+ L   +E+ 
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH-QEQG 1373

Query: 652  QKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
            +K +EEE+ R+R +E +R  +L+ + Q   Q  E Q+R +++   +K REE   +Q+  R
Sbjct: 1374 RKFLEEEQ-RLRRQERER-KFLKEEQQLRCQEREQQLRQDRD---RKFREE---EQQLSR 1425

Query: 712  ASLEQKNRQMLEQLK-EEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEH 770
               ++K R+  +Q++ +E E     E+  L   + +  ++  EQL  ER+E     ++ H
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE-EEQLLQEREE-----QQLH 1479

Query: 771  SAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEH 830
              E +R    LE + +       +K +E + + +   +K L + E ++H++       + 
Sbjct: 1480 RQERDR--KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEE-EQQLHRQQRQRKFLQE 1536

Query: 831  ELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELER 890
            E     +E+ Q+   + +R   K +EE Q    +  +Q   +ER ++  L        E+
Sbjct: 1537 EQQLRRQERGQQRRQDRDR---KFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593

Query: 891  LQRAHERELETVRQEQHKRLEDLR-RRHREQERKLQDLE-LDLETRAKDVKARLALLEVQ 948
             ++  E E +  RQE  ++L   R R+ RE E+ LQ+ E   L  + +D K     LE +
Sbjct: 1594 ERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK----FLEEE 1649

Query: 949  EETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARK 1008
             +  R+E++Q L   R    + EE     Q L+E +++     + +++ RE   +L+ ++
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEE-----QLLQEGEEQQLRRQERDRKFREEEQQLRRQE 1704

Query: 1009 LKLESQVDLLQAQSQQLQKHF-------SSLEAEAQKKQHLLREVTVEENNASPHFEPDL 1061
             + +   +  Q + Q+L++ F          E E  ++Q   R++  EE        P+ 
Sbjct: 1705 RERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ-----LRPER 1759

Query: 1062 HIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQT 1121
              + LR+     + +E    L Q +E+  L S  S   +     E   LR  +E   QQ 
Sbjct: 1760 EEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFR----EEEQLRQERE--EQQL 1812

Query: 1122 RSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRK 1181
            R  +R                                 D +   E+E   L+E +  +R+
Sbjct: 1813 RPQQR---------------------------------DGKYRWEEEQLQLEEQEQRLRQ 1839

Query: 1182 GHNLLKKKE------EKLNQLESSLWEE 1203
              +   + E      EK  + E  LW+E
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQE 1867



 Score =  128 bits (321), Expect = 5e-29
 Identities = 190/844 (22%), Positives = 339/844 (40%), Gaps = 106/844 (12%)

Query: 438  RQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL---PHEERAQSPPRSLATEEEP 494
            R+ QQ    E ++  +  ++  + +  +  EER    L     EER +   R    EE  
Sbjct: 314  RREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERR 373

Query: 495  PQGPEGQPEWKEAEELGEDSAASLSLQL----------------SLQREQAPSPPAACEK 538
             Q    + + +  ++L  +       QL                 L+REQ        E+
Sbjct: 374  EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEER 433

Query: 539  GKEQHSQA---EELGPGQEEAED---PEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAAL 592
             +++H Q    + L   QEE  D    EE+           +++  +     E+  E  L
Sbjct: 434  HEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE----EERRERWL 489

Query: 593  KAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEI---LRLHQQKEQSLSSLRE 649
            K  EE   +  E+ ++ L   ++E+ +Q  ++  QEEEE +   LR  QQ  +     RE
Sbjct: 490  KLEEEERREQQERREQQLRREQEERREQRLKR--QEEEERLQQRLRSEQQLRREQEERRE 547

Query: 650  RLQKAIEEE-------EARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKL--R 700
            +L K  EE+       E R++ E+ +R   L  + +   Q    +++ EQE  L++   R
Sbjct: 548  QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ---QRLKREQEERLEQRLKR 604

Query: 701  EELE----SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE 756
            EE+E     +++ +R   E+   +  +QL +  E  E+ +Q      +E+  Q+L+ + E
Sbjct: 605  EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 757  GERKEAVATLEKEHSAELERLCSSLEAKHREVVSS--------LQKKIQEAQQKEEAQLQ 808
             ER E     E E     + L    + + RE + S        L+ +    Q K  ++ +
Sbjct: 665  EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 809  KCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRL-------DKMKEEHQQV 861
            K  GQ   +  ++       E +     R  RQ+ E E  R         +K +   Q++
Sbjct: 725  KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784

Query: 862  MAKA--REQYE----AEERKQRAELLGHLTGELE---RLQRAHERELETVRQEQHKRL-- 910
             A+   REQ E    AEER+QR +       E E   R +R  E+EL+ + +E+  +   
Sbjct: 785  SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 911  -------------EDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQ 957
                         ED  RR  +++R+ Q     LE   K  +  L      +E  R+E Q
Sbjct: 845  RAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE-Q 903

Query: 958  QLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDL 1017
            QLL  + +   + E      Q+ E   +E   L Q  +QL   L E + ++ + E +   
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQL---LREEREKRRRQERERQY 960

Query: 1018 LQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKE 1077
             + +  Q QK    L  E +K++   RE    E       E  L  E+  K       ++
Sbjct: 961  RKDKKLQ-QKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQ 1019

Query: 1078 V--SSSLSQSKEDLYLDSLSSHNVW--HLLSAEGVALRSAKEFLVQQTRSMRRRQTALKA 1133
                  L Q +E L  +      +        E   L+  +E L+ + R  RRRQ     
Sbjct: 1020 YRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQ----E 1075

Query: 1134 AQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKL 1193
             ++ +R E    +E+ ++   +   E  ++  ++  R   E +   ++   LL+++ EK 
Sbjct: 1076 LERQYRKE----EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131

Query: 1194 NQLE 1197
             + E
Sbjct: 1132 RRQE 1135



 Score =  128 bits (321), Expect = 5e-29
 Identities = 174/798 (21%), Positives = 335/798 (41%), Gaps = 93/798 (11%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEK-EAPEDTVDAGEEGSRREEAAKEPKK 370
            E+EE ++ E ++ R     +         +  E+ +  E+ +   E+  RR+E  ++ ++
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 371  KASALEEGSSDASQELEISEHMK---EPQLSDSIASDPKSFHGLDFG-FRSRISEHLLDV 426
            +     +      ++ +    +K   EP+  +++  +     G +   FR      L D 
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRD- 1260

Query: 427  DVLSPVLGGACRQAQQPL----GIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQ 482
                       RQ+QQ L    G + + D +  +   Q +     EE     L  EE+ +
Sbjct: 1261 -----------RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEE---QLEREEQKE 1306

Query: 483  SPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQ 542
            +  R   ++EE     E + E +  +E   D       QL  +RE+ P       + +++
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQET--DRKFREEEQLLQEREEQPLR----RQERDR 1360

Query: 543  HSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQV 602
              + EEL   ++  +  EE            E R        + L E      +E   Q+
Sbjct: 1361 KFREEELRHQEQGRKFLEE------------EQRLRRQERERKFLKEEQQLRCQEREQQL 1408

Query: 603  LEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKE--QSLSSLRERLQKAIEEEEA 660
             +   R   E +Q+  +Q R++  +EEE+++ R  ++++  +    LR+   +   EEE 
Sbjct: 1409 RQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 661  RMREEESQRL-------SWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS 713
             ++E E Q+L        +L  + Q   Q  + + R ++  S +  R+ LE +Q+  R  
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 714  LEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATL----EKE 769
             ++K  Q  +QL+ +    ++ +       +E+ L+Q RE+ +  R+E         +K 
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKV 1588

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               E ER     E + R      Q + QE  +K     Q    + E ++H++       E
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLR-QERDRKFREDEQLLQEREEQQLHRQERDRKFLE 1647

Query: 830  HELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELE 889
             E     +E+ Q++  + +R   K +EE Q +     +Q   +ER ++         E E
Sbjct: 1648 EEPQLRRQEREQQLRHDRDR---KFREEEQLLQEGEEQQLRRQERDRKFR-------EEE 1697

Query: 890  RLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            +  R  ERE + +++EQ  R ++L R+ RE+E+  Q+ E +   R +  +    +LE ++
Sbjct: 1698 QQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR---KILEEEQ 1754

Query: 950  ETARREKQQLLDVQRQVALKSEEATATHQQLEEAQ---KEHTHLLQSNQQLREILDELQA 1006
                RE+QQL   +R    + EE     Q+ EE Q   +E     +  +QLR+  +E Q 
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEE--QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQL 1812

Query: 1007 R------KLKLESQVDLLQAQSQQL----------QKHFSSLEAEAQKKQHLLREVTVEE 1050
            R      K + E +   L+ Q Q+L          ++ F++ E   +++Q L +E   EE
Sbjct: 1813 RPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE---EE 1869

Query: 1051 NNASPHFEPDLHIEDLRK 1068
                   E  L  E +R+
Sbjct: 1870 QKRRQERERKLREEHIRR 1887



 Score =  121 bits (304), Expect = 4e-27
 Identities = 140/620 (22%), Positives = 267/620 (43%), Gaps = 72/620 (11%)

Query: 604  EQDQRHLL---ESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            E+DQR         +E+  Q R +  QE+E E+    +Q E+         Q+ +E+ + 
Sbjct: 116  EEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEK---------QERLEQRDR 166

Query: 661  RMREEE--SQRLSWLRAQVQSSTQADEDQIRA-------EQEASLQKLREELESQQKAER 711
            + R+EE   QR  W   Q +   +A+E+Q+++       E     Q  R EL   ++  R
Sbjct: 167  QRRDEELWRQRQEW---QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGR 223

Query: 712  ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHS 771
               +Q+ R+  +++ +E E  E  ++  +   +E+ LQ+   Q + E +E    L K   
Sbjct: 224  EEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLER 283

Query: 772  AELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHE 831
             EL R         R+     Q++++  QQ    Q ++   Q E R  Q           
Sbjct: 284  QELRR--------ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ----------- 324

Query: 832  LSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL 891
                 +E+R++ E   E++L + +EE ++   +  ++ E  E++ R E       E ER 
Sbjct: 325  -----QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRRE------QEEERR 373

Query: 892  QRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEET 951
            ++   RE +  R++Q +R + LRR   +Q R+ Q L  + + R +    R   L  ++E 
Sbjct: 374  EQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQQLRREQQLRREQEE 431

Query: 952  ARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKL 1011
             R E++   + + Q   + +E      + EE  + H    +  Q  R+  +E + R LKL
Sbjct: 432  ERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 1012 ESQV--DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDL--HIEDLR 1067
            E +   +  + + QQL++     E E +++Q L R+   E        E  L    E+ R
Sbjct: 492  EEEERREQQERREQQLRR-----EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546

Query: 1068 KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR 1127
            + L     +E    L Q + +  L          LL  E    +   +   ++    R +
Sbjct: 547  EQL---LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603

Query: 1128 QTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLK 1187
            +  ++  +Q  R E    Q + ++ P  +  + + K+ E+E R   +++   ++      
Sbjct: 604  REEVERLEQEERRE----QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRL 659

Query: 1188 KKEEKLNQLESSLWEEASDE 1207
            K+EE+  +LE  L  E  +E
Sbjct: 660  KREEEEERLEQRLKREHEEE 679



 Score =  120 bits (300), Expect = 1e-26
 Identities = 150/645 (23%), Positives = 280/645 (43%), Gaps = 75/645 (11%)

Query: 601  QVLEQDQRHLLESKQ--EKMQQLREKLCQEEEEEILRLHQ--QKEQSLSSLRERLQKAIE 656
            Q  ++ +R L E ++  EK ++L ++  Q  +EE+ R  Q  Q+ +   +  E+LQ    
Sbjct: 139  QKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198

Query: 657  EEEARMREEESQRLSWL-------RAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
             E     +EE  R   L       R + Q   +  +D++  E+E    + RE +  +++ 
Sbjct: 199  HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKE 769
            +    E + ++ L++ +E++   E+ E       +E+  Q+LR + +  RK+     E+E
Sbjct: 259  KLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-----EEE 313

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               + E      E + ++     Q+  +E +++ E QL++   Q E R  Q+       E
Sbjct: 314  RREQQEERREQQERREQQEERREQQLRREQEERREQQLRR--EQEEERREQQLRREQEEE 371

Query: 830  HELSSLLRE----KRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLT 885
                 L RE    + Q++  E + R ++     QQ+    REQ    E++ R E      
Sbjct: 372  RREQQLRREQQLRREQQLRREQQLRREQQLRREQQL---RREQQLRREQQLRREQQLRRE 428

Query: 886  GELERLQRAHEREL--ETVRQEQHKRLEDLRR----RHREQERKLQDLELDLETRAKDVK 939
             E ER ++ HE+E   + +++EQ +R + L+R       EQER+ Q L+ D E   ++  
Sbjct: 429  QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH--THLLQSNQQL 997
             +L      EE  RRE+Q+    +R+  L+ E+     Q+L+  ++E      L+S QQL
Sbjct: 489  LKL------EEEERREQQE----RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 998  REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            R   +E + + LK E +  L Q + +Q  K     E E ++ Q L RE    +       
Sbjct: 539  RREQEERREQLLKREEEKRLEQERREQRLKR----EQEERRDQLLKREEERRQQRLKREQ 594

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
            E     E L + L   + + +     + ++ L  +         LL +E    R  ++  
Sbjct: 595  E-----ERLEQRLKREEVERLEQE-ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648

Query: 1118 VQQTRSMRRRQTALKAAQQHWR--------HELASAQEVAKDPPGIKALEDMRKNLEKET 1169
             +Q     RR+  LK  ++  R        HE    ++   +    +A E ++  + K  
Sbjct: 649  REQ---QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQ 705

Query: 1170 RHLDEMKSA----------MRKGHNLLKKKEEKLNQLESSL-WEE 1203
              L+    A           ++G    +++EEK  + ES L W+E
Sbjct: 706  WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 145/707 (20%), Positives = 309/707 (43%), Gaps = 89/707 (12%)

Query: 311  PEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKK 370
            PE+E+ E+ E K  +     + D    E  +   +E         EE  RR+E  ++ ++
Sbjct: 1294 PEEEQLEREEQKEAK-----RRDRKSQEEKQLLREER--------EEKRRRQETDRKFRE 1340

Query: 371  KASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLS 430
            +   L+E      +  E     +E +L        + F  L+   R R  E   +   L 
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQ--EQGRKF--LEEEQRLRRQER--ERKFLK 1394

Query: 431  PVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLAT 490
                  C++ +Q L  +D+D     +++  S+Q +  + R       + R Q   R    
Sbjct: 1395 EEQQLRCQEREQQLR-QDRDRKFREEEQQLSRQERDRKFREEE---QQVRRQERERKFL- 1449

Query: 491  EEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELG 550
            EEE     E   +++E E+L ++       +  L R+         E+ ++   + ++L 
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQERE-----EQQLHRQ---------ERDRKFLEEEQQLR 1495

Query: 551  PGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHL 610
              + + +  E+            E+RS EP    + L E      ++   + L+++Q+  
Sbjct: 1496 RQERDRKFREQ------------ELRSQEPER--KFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 611  LESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQK-AIEEEEARMREEESQR 669
             + + ++ +Q R++  +EEE+    L Q++E+   S +ER +K  +EE++ R +E+E + 
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQ----LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597

Query: 670  LS----WLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQ----KNRQM 721
            +       R + Q   + + D+   E E  LQ+  E+   +Q+ +R  LE+    + ++ 
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657

Query: 722  LEQLKEEIEASEKSEQAALNAAKEKALQ-QLREQLEGERKEAVATLEKEHS---AELERL 777
             +QL+ + +   + E+  L   +E+ L+ Q R++   E ++ +   E+E      E +  
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS---- 833
               LE K RE    L+++ ++ Q + + + +K L + + R  ++   +   E +      
Sbjct: 1718 RQELERKFREE-EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776

Query: 834  SLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA----------EERKQRAELLGH 883
              LR++R+E +   +    K +EE Q    +  +Q             EE+ Q  E    
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836

Query: 884  LTGELERLQRAHER---ELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKA 940
            L  E +R  RA E+   + ++ R+EQ    E+ ++R +E+ERKL+  E  +  + K+ + 
Sbjct: 1837 LRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLR--EEHIRRQQKEEQR 1894

Query: 941  RLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH 987
               + E++ +  +   + L     Q A     ++  ++ ++E + ++
Sbjct: 1895 HRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRSSPLYEYIQEQRSQY 1941



 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 81/387 (20%), Positives = 162/387 (41%), Gaps = 24/387 (6%)

Query: 817  RVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQ 876
            +V Q  Y+  G   + + L  EKR   +G+     D+ +EE Q+       Q E E  ++
Sbjct: 80   KVAQACYYALG---QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR 136

Query: 877  RAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHRE----QERKLQDLELDL- 931
            R +       EL   +   E++    ++++ +R E+L R+ +E    +ER+ ++ +L   
Sbjct: 137  RRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196

Query: 932  ------ETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQK 985
                  E   ++   R  LLE++ +  R EKQQ    ++    + EE     ++    +K
Sbjct: 197  KGHETEEFPDEEQLRRRELLELRRK-GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRK 255

Query: 986  EHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            E   L +   Q +  L E + +  KLE Q    + Q ++ Q+     E + ++KQ   R 
Sbjct: 256  EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 1046 VTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSA 1105
               EE         +   E   + L   Q +     L + +E    +      +      
Sbjct: 316  EQQEERREQQE-RREQQEERREQQLRREQEERREQQLRREQE----EERREQQLRREQEE 370

Query: 1106 EGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNL 1165
            E    +  +E  +++ + +RR Q   +  Q     +L   Q++ ++   ++  + +R+  
Sbjct: 371  ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ-LRREQQLRREQ 429

Query: 1166 EKETRHLDEMKSAMRKGHNLLKKKEEK 1192
            E+E RH  E K    +    LK+++E+
Sbjct: 430  EEE-RH--EQKHEQERREQRLKREQEE 453


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1708 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1753

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1754 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1808

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1868

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2045

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2106 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2223

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2455

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2516 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2571 EELQQLE 2577



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1442 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1535

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1643

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1644 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1695

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1751

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1812 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1926

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1927 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2046 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2082

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2083 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2133

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1460 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1514 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1568

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1621

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1675

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1856 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1914 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1966

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1967 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2077 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2431

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2488

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2489 QALQQSFLSEKDSL 2502



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2033

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2268

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2329 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1956 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2246

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2307 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2482

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2483 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2539

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2540 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2584

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2585 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2618



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1546 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1598

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1659 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1892

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1893 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 1203 EAS 1205
            E S
Sbjct: 2072 EQS 2074



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1066

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1067 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1247 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1478 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1525

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1584

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1640

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1696

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1697 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAE 1775



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2296

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2536 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2650

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2651 RKVSAQRLQEAGILSA 2666



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 457  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 512

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 513  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 562

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 563  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 613

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 614  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 668

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 669  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 725

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 726  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 785

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 786  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 841

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 842  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 890

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 891  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 944  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 996  LEACETRTVHRLRLPLDK 1013


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1652 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1711

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1712 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1757

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1758 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1812

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1813 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1872

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1873 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1932

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1933 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1992

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1993 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2049

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2050 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2109

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2110 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2168

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2169 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2227

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2228 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2287

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2288 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2347

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2348 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2407

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2459

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2460 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2519

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2520 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2574

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2575 EELQQLE 2581



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1386 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1445

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1446 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1490

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1491 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1539

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1540 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1599

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1600 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1647

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1648 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1699

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1700 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1755

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1756 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1815

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1816 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1874

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1875 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1930

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1931 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1989

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1990 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2049

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2050 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2086

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2087 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2137

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1404 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1463

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1464 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1517

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1518 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1572

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1573 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1625

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1626 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1679

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1739

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1740 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1799

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1800 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1859

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1860 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1917

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1918 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1970

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1971 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2020

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2021 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2080

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2081 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2139

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2140 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2199

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2435

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2436 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2492

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2493 QALQQSFLSEKDSL 2506



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1866 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1923

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1924 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1979

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1980 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2037

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2038 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2097

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2157

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2158 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2217

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2218 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2272

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2273 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2332

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2333 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2390 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2449

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2450 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2509

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2510 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2569

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2570 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2600



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1899

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1900 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1959

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1960 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 2012

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 2013 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2072

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2073 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2132

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2133 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2192

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2193 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2250

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2251 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2310

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2311 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2368

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2369 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2486

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2487 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2543

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2544 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2588

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2589 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2622



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1370 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1429

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1430 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1489

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1549

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1550 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1602

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1662

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1663 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1779

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1780 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1839

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1840 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1896

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1897 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1955

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075

Query: 1203 EAS 1205
            E S
Sbjct: 2076 EQS 2078



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 1011 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1070

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1071 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1130

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1131 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1190

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1191 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1250

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1251 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1482 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1529

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1530 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1588

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1589 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1644

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1645 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1700

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1701 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1756

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1757 LEAELAKVRAEMEVLLASKARAE 1779



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2184

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2185 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2242

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2243 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2300

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2301 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2359

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2360 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2419

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2420 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2479

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2480 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2539

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2540 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2598

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2599 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2654

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2655 RKVSAQRLQEAGILSA 2670



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 461  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 516

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 517  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 566

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 567  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 617

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 618  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 672

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 673  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 729

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 730  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 789

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 790  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 845

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 846  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 894

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 895  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 947

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 948  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 999

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 1000 LEACETRTVHRLRLPLDK 1017


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1648 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1707

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1708 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1753

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1754 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1808

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1809 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1868

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1869 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1928

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1929 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1988

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1989 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2045

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2046 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2105

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2106 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2164

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2165 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2223

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2224 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2283

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2284 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2343

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2344 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2403

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2455

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2456 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2515

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2516 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2570

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2571 EELQQLE 2577



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1382 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1441

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1442 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1486

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1487 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1535

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1536 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1595

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1596 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1643

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1644 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1695

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1696 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1751

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1752 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1811

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1812 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1870

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1871 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1926

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1927 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1985

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1986 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2045

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2046 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2082

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2083 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2133

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1400 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1459

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1460 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1513

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1514 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1568

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1569 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1621

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1622 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1675

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1735

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1736 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1795

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1796 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1855

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1856 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1913

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1914 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1966

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1967 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2077 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2135

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2136 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2195

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2431

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2432 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2488

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2489 QALQQSFLSEKDSL 2502



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1862 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1919

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1920 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1975

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1976 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2033

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2034 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2093

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2153

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2154 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2213

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2214 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2268

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2269 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2328

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2329 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2386 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2445

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2446 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2505

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2506 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2565

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2566 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2596



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1895

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1896 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1955

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1956 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 2008

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 2009 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2068

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2069 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2128

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2129 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2188

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2189 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2246

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2247 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2306

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2307 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2364

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2365 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2482

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2483 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2539

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2540 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2584

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2585 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2618



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1366 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1425

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1426 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1485

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1545

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1546 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1598

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1658

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1659 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1775

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1776 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1835

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1836 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1892

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1893 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1951

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071

Query: 1203 EAS 1205
            E S
Sbjct: 2072 EQS 2074



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 1007 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1066

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1067 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1126

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1127 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1186

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1187 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1246

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1247 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1478 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1525

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1526 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1584

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1585 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1640

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1641 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1696

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1697 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1752

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1753 LEAELAKVRAEMEVLLASKARAE 1775



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2180

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2181 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2238

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2239 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2296

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2297 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2355

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2356 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2415

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2416 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2475

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2476 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2535

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2536 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2594

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2595 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2650

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2651 RKVSAQRLQEAGILSA 2666



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 457  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 512

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 513  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 562

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 563  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 613

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 614  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 668

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 669  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 725

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 726  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 785

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 786  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 841

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 842  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 890

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 891  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 943

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 944  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 995

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 996  LEACETRTVHRLRLPLDK 1013



 Score = 30.8 bits (68), Expect = 10.0
 Identities = 18/61 (29%), Positives = 30/61 (49%), Gaps = 3/61 (4%)

Query: 1133 AAQQHWRHELASAQEVAKDPPGIKA---LEDMRKNLEKETRHLDEMKSAMRKGHNLLKKK 1189
            AA  HWR     AQ+   +   ++     + + K+L K  RH+ ++   +R GHNL+   
Sbjct: 21   AAVWHWRRGRRWAQDEQDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLL 80

Query: 1190 E 1190
            E
Sbjct: 81   E 81


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1616 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1675

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1676 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1721

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1722 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1776

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1777 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1836

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1837 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1896

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1897 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1956

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1957 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2013

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2014 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2073

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2074 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2132

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2133 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2191

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2192 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2251

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2252 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2311

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2312 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2371

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2423

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2424 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2483

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2484 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2538

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2539 EELQQLE 2545



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1350 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1409

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1410 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1454

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1455 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1503

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1504 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1563

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1564 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1611

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1612 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1663

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1664 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1719

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1720 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1779

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1780 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1838

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1839 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1894

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1895 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1953

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1954 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2013

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2014 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2050

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2051 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2101

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1368 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1427

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1428 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1481

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1482 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1536

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1537 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1589

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1590 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1643

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1703

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1704 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1763

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1764 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1823

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1824 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1881

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1882 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1934

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1935 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 1984

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 1985 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2044

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2045 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2103

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2104 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2163

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2399

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2400 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2456

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2457 QALQQSFLSEKDSL 2470



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1830 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1887

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1888 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1943

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1944 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2001

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2002 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2061

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2121

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2122 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2181

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2182 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2236

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2237 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2296

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2297 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2354 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2413

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2414 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2473

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2474 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2533

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2534 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2564



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1863

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1864 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1923

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1924 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 1976

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 1977 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2036

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2037 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2096

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2097 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2156

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2157 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2214

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2215 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2274

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2275 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2332

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2333 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2450

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2451 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2507

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2508 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2552

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2553 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2586



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1334 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1393

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1394 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1453

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1513

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1514 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1566

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1626

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1627 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1743

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1744 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1803

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1804 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1860

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1861 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1919

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039

Query: 1203 EAS 1205
            E S
Sbjct: 2040 EQS 2042



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 975  LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1034

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1035 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1094

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1095 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1154

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1155 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1214

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1215 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1446 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1493

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1494 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1552

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1553 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1608

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1609 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1664

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1665 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1720

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1721 LEAELAKVRAEMEVLLASKARAE 1743



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2148

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2149 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2206

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2207 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2264

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2265 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2323

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2324 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2383

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2384 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2443

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2444 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2503

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2504 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2562

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2563 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2618

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2619 RKVSAQRLQEAGILSA 2634



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 425  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 480

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 481  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 530

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 531  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 581

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 582  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 636

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 637  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 693

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 694  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 753

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 754  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 809

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 810  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 858

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 859  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 911

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 912  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 963

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 964  LEACETRTVHRLRLPLDK 981


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1845 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1890

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1891 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1945

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1946 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 2005

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 2006 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 2065

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 2066 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 2126 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2182

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2242

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2243 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2360

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2421 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2592

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2593 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2652

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2653 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2707

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2708 EELQQLE 2714



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1519 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1578

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1579 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1623

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1672

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1780

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1781 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1832

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1833 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1888

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1949 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 2063

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 2064 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2183 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2219

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2220 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2270

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1537 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1596

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1597 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1651 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1705

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1706 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1758

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1759 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1812

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1932

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1933 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1992

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1993 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 2050

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 2051 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 2103

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 2104 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2153

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2154 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2213

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2214 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2272

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2568

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2569 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2625

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2626 QALQQSFLSEKDSL 2639



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1999 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 2056

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 2057 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 2112

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 2113 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2170

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2230

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2290

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2291 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2350

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2351 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2405

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2406 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2465

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2466 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2523 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2582

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2583 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2702

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2703 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2733



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 2093 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 2145

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2265

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2266 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2383

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2384 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2443

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2444 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2619

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2620 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2676

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2677 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2721

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2722 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2755



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1503 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1683 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1735

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1796 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 2029

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 2030 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208

Query: 1203 EAS 1205
            E S
Sbjct: 2209 EQS 2211



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 1144 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1203

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1204 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1263

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1264 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1323

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1384 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1615 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1662

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1663 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1721

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1722 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1777

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1833

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1834 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1889

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1890 LEAELAKVRAEMEVLLASKARAE 1912



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2317

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2318 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2433

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2434 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2492

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2493 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2552

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2613 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2672

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2673 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2731

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2732 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2787

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2788 RKVSAQRLQEAGILSA 2803



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 594  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 649

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 650  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 699

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 700  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 750

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 751  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 805

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 806  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 862

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 863  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 922

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 923  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 978

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 979  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 1027

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 1028 KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 1081 GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1132

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 1133 LEACETRTVHRLRLPLDK 1150


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1686 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1731

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1732 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1786

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1787 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1846

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1847 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1906

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1907 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1967 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2023

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2083

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2084 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2201

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2262 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2433

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2434 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2493

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2494 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2548

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2549 EELQQLE 2555



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1360 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1419

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1420 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1464

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1465 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1513

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1621

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1622 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1673

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1674 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1729

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1790 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1848

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1849 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1904

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1905 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2024 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2060

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2061 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2111

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1378 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1437

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1438 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1492 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1546

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1547 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1599

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1600 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1653

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1773

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1774 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1833

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1834 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1891

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1892 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1944

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1945 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 1994

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2055 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2113

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2409

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2410 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2466

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2467 QALQQSFLSEKDSL 2480



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1840 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1897

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1898 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1953

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1954 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2011

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2071

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2131

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2132 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2191

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2192 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2246

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2247 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2306

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2307 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2364 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2423

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2424 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2543

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2544 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2574



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1873

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1934 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 1986

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2106

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2107 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2224

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2225 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2284

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2285 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2460

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2461 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2517

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2518 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2562

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2563 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2596



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1524 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1576

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1637 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1870

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1871 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049

Query: 1203 EAS 1205
            E S
Sbjct: 2050 EQS 2052



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 985  LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1044

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1045 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1104

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1105 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1164

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1225 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1456 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1503

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1504 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1562

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1563 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1618

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1674

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1675 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1730

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1731 LEAELAKVRAEMEVLLASKARAE 1753



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2158

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2159 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2274

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2275 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2333

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2334 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2393

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2454 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2513

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2514 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2572

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2573 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2628

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2629 RKVSAQRLQEAGILSA 2644



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 435  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 490

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 491  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 540

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 541  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 591

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 592  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 646

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 647  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 703

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 704  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 763

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 764  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 819

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 820  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 868

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 869  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 921

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 922  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 973

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 974  LEACETRTVHRLRLPLDK 991


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1634 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1693

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1694 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1739

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1740 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1794

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1795 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1854

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1855 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1914

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1915 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1974

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 1975 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2031

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2032 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2091

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2092 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2150

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2151 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2209

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2210 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2269

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2270 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2329

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2330 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2389

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2441

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2442 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2501

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2502 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2556

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2557 EELQQLE 2563



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1368 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1427

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1428 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1472

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1473 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1521

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1522 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1581

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1582 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1629

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1630 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1681

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1682 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1737

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1738 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1797

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1798 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1856

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1857 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1912

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1913 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1971

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 1972 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2031

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2032 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2068

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2069 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2119

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1386 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1445

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1446 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1499

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1500 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1554

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1555 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1607

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1608 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1661

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1721

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1722 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1781

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1782 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1841

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1842 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1899

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1900 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1952

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1953 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2063 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2121

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2122 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2181

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2301

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2417

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2418 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2474

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2475 QALQQSFLSEKDSL 2488



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1848 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1905

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1906 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 1961

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 1962 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2019

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2020 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2079

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2139

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2140 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2199

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2200 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2254

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2255 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2314

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2315 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2372 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2431

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2432 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2491

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2492 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2551

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2552 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2582



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1881

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1882 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1941

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1942 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 1994

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 1995 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2054

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2055 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2114

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2115 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2174

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2175 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2232

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2233 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2292

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2293 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2350

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2351 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2468

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2469 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2525

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2526 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2570

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2571 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2604



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1352 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1411

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1412 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1471

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1531

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1532 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1584

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1644

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1645 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1761

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1762 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1821

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1822 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1878

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1879 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1937

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057

Query: 1203 EAS 1205
            E S
Sbjct: 2058 EQS 2060



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 993  LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1052

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1053 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1112

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1113 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1172

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1173 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1232

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1233 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1464 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1511

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1512 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1570

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1571 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1626

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1627 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1682

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1683 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1738

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1739 LEAELAKVRAEMEVLLASKARAE 1761



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2166

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2167 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2224

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2225 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2282

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2283 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2341

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2342 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2401

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2402 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2461

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2462 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2521

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2522 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2580

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2581 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2636

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2637 RKVSAQRLQEAGILSA 2652



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 443  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 498

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 499  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 548

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 549  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 599

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 600  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 654

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 655  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 711

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 712  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 771

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 772  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 827

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 828  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 876

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 877  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 929

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 930  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 981

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 982  LEACETRTVHRLRLPLDK 999


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score =  134 bits (338), Expect = 5e-31
 Identities = 211/967 (21%), Positives = 427/967 (44%), Gaps = 149/967 (15%)

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSD---ASQELEISEHMKEPQLSD 399
            +E+ A + ++   E   ++EEA +E +++  A E+       A QELE    + E     
Sbjct: 1675 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1734

Query: 400  SIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDEL 459
             +A++ +         R+   +      +L   L    R+A           +   + EL
Sbjct: 1735 RLAAEQELIR-----LRAETEQGEQQRQLLEEELARLQREAAA---------ATQKRQEL 1780

Query: 460  QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
            +++ +K +   +   L  + RA+   RS  T E+  Q  E   E     EL E++A   +
Sbjct: 1781 EAELAK-VRAEMEVLLASKARAEEESRS--TSEKSKQRLEA--EAGRFRELAEEAARLRA 1835

Query: 520  LQLSLQRE-QAPSPPAACEKGKEQHSQAEELGP-GQEEAEDPEEKVAVSPTPPVSPEVR- 576
            L    +R+ Q     AA ++ + +   AE+L   G+      E ++A+      +  +R 
Sbjct: 1836 LAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRR 1895

Query: 577  -STEPVAPPEQLSEAALKA---MEEAVAQVLE------QDQRHLLESKQEKMQQLREKLC 626
             + +      +L E A +    +EE +AQ+ +      + Q+ L+E    + +Q+ E++ 
Sbjct: 1896 LAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEIL 1955

Query: 627  Q-------------EEEEEILRLHQQKEQSLSS------------------------LRE 649
                          E E E+ R+    E +L S                          E
Sbjct: 1956 ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2015

Query: 650  RLQKAI--EEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ------KLRE 701
            R+QK++  EEE AR R+   + +  L+A+V+ + +  E   RAEQE++ Q        ++
Sbjct: 2016 RVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE---RAEQESARQLQLAQEAAQK 2072

Query: 702  ELESQQKAERASLEQKNRQM----------LEQLKEEIEAS----EKSEQAALNAAKEKA 747
             L++++KA   +++QK +++          L+QL+ E EA+    E++E+A + A +E A
Sbjct: 2073 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAA 2132

Query: 748  LQQLREQLEGER------KEAVATLEKEHSAELERLCSSLEAKHR---EVVSSLQKKIQE 798
             Q  R+  E ER      ++A A  + + +AE  R  +  EA  R   E  +  QK+  +
Sbjct: 2133 -QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2191

Query: 799  AQQKEEA----QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHE---RRL 851
            A+ ++      Q  +   QVE  +      +   +H+  +LL E+ Q ++ E     R+ 
Sbjct: 2192 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ-KNLLDEELQRLKAEATEAARQR 2250

Query: 852  DKMKEE------HQQVMAKAREQYEAEER----KQRAELLGHLTGELERLQR-AHERELE 900
             +++EE        + ++K + + EAE R    + +      L  E E++++ A E    
Sbjct: 2251 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2310

Query: 901  TVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD----VKARLALLEVQEETARREK 956
            +V  ++  RL  L      Q+R L +  L  + +A      +KA   LL+ Q+E A+ + 
Sbjct: 2311 SVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2370

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSN-QQLREILDELQARKLKLESQV 1015
            ++L + + Q+A +  E T   Q+  EA+++    + +  ++L+  + E+   + + E   
Sbjct: 2371 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2430

Query: 1016 DLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQT 1075
               + Q++++ +     E   Q+K  L++ + ++   +      D   E LR+++   + 
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS------DHDAERLREAIA--EL 2482

Query: 1076 KEVSSSLSQSKEDLYLDSLSSHNVWH-LLSAEGVALR----SAKEFLVQQTRSMRRRQTA 1130
            +     L Q  + L L S     V    L  E  AL+    S K+ L+Q+ R + + +  
Sbjct: 2483 EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAK 2542

Query: 1131 LKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKE 1190
            L   +Q ++ E+A AQ++ ++    +  + M +  ++    ++E +    +    +++K+
Sbjct: 2543 L---EQLFQDEVAKAQQLREEQQ--RQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQ 2597

Query: 1191 EKLNQLE 1197
            E+L QLE
Sbjct: 2598 EELQQLE 2604



 Score =  118 bits (295), Expect = 5e-26
 Identities = 213/895 (23%), Positives = 357/895 (39%), Gaps = 112/895 (12%)

Query: 340  AKA-SEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            AKA +E+EA E      EE  RREEAA + +++  +++E      Q  E     K  Q  
Sbjct: 1409 AKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAE 1468

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
             +  S            R RI E   ++ V+   L    RQ     G      +++ + E
Sbjct: 1469 AAERS------------RLRIEE---EIRVVRLQLEATERQRGGAEGELQALRARAEEAE 1513

Query: 459  LQSKQSKGLEERLSPPLPHE-ERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             Q +Q++   ERL   +  E +R +     LA+  +            EAE   E   A 
Sbjct: 1514 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-----------EAEAAREKQRAL 1562

Query: 518  LSLQ-LSLQREQAPSPPAACEKGKEQHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEV 575
             +L+ L LQ E+A       E  + +  Q A E      EAE   ++ + +         
Sbjct: 1563 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1622

Query: 576  RSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E VA  +   EA  +A ++A A+   ++    LE  Q K              E LR
Sbjct: 1623 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN------------EALR 1670

Query: 636  LHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEAS 695
            L  Q E+         QK++ + EA  ++EE++R +  R + ++  QA   +  AEQE  
Sbjct: 1671 LRLQAEEVAQ------QKSLAQAEAEKQKEEAEREA--RRRGKAEEQAVRQRELAEQELE 1722

Query: 696  LQK------LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
             Q+       ++ L ++Q+  R   E +  +   QL EE  A  + E AA    +    Q
Sbjct: 1723 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR----Q 1778

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR-EVVSSLQKKIQEAQQK-----E 803
            +L  +L   R E    L  +  AE E   +S ++K R E  +   +++ E   +     E
Sbjct: 1779 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1838

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
            EA+ Q+ L + E    Q++        +L+++    R + E E   +  + + E  + +A
Sbjct: 1839 EAKRQRQLAE-EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 1897

Query: 864  KAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +          +Q A+    +   L +L++A + ELE     Q   +ED  R+ R+ E +
Sbjct: 1898 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE----RQKGLVEDTLRQRRQVEEE 1953

Query: 924  LQDLELDLETRAKDVKARLAL-----LEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            +  L+   E +A   KA L L         E+T R ++Q  L+  RQ  L +EE     +
Sbjct: 1954 ILALKASFE-KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2012

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
              E  QK      ++ +Q +  L+E++  K K+E    L +   Q+  +     +  AQK
Sbjct: 2013 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2072

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
            +                     L  E+   +    Q KE     +  +E   LD L    
Sbjct: 2073 R---------------------LQAEEKAHAFAVQQ-KEQELQQTLQQEQSVLDQLRGE- 2109

Query: 1099 VWHLLSAEGVALRSAKEFLVQQTR--SMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK 1156
                  A   A   A+E  VQ  R  +  RRQ       +    E A A+  A+      
Sbjct: 2110 ----AEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ-----A 2160

Query: 1157 ALEDMRKNLEKE-TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            A E +RK  E+E  R     ++A+R+      + E+     E +L ++A  E  L
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215



 Score =  117 bits (294), Expect = 6e-26
 Identities = 255/1154 (22%), Positives = 442/1154 (38%), Gaps = 191/1154 (16%)

Query: 216  EETNEEDEEESDNQSVHSSSEPLRNLH----LDIGALGGDFEYEESLRTSQPEEKKDVSL 271
            E    E+      Q   S  E L+ L      +I A     E  E  R    EE + V L
Sbjct: 1427 EVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRL 1486

Query: 272  DSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEK----SEPKICRNL 327
              +A       +    GA+  L +   +  +    +    E+ E  +     E +  R  
Sbjct: 1487 QLEAT------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1540

Query: 328  VTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE 387
                A    +E   A EK+     + A EE   + E A+   ++A    E +      LE
Sbjct: 1541 EVELASRVKAEAEAAREKQR---ALQALEELRLQAEEAERRLRQAEV--ERARQVQVALE 1595

Query: 388  ISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
             ++   E +L    AS  +    L+   RS   EH+     ++ +   A R+AQQ    E
Sbjct: 1596 TAQRSAEAELQSKRASFAEKTAQLE---RSLQEEHV----AVAQLREEAERRAQQQAEAE 1648

Query: 448  D-KDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
              +++++   +  Q K ++ L  RL      EE AQ   +SLA  E   Q  E + E + 
Sbjct: 1649 RAREEAERELERWQLKANEALRLRLQA----EEVAQQ--KSLAQAEAEKQKEEAEREARR 1702

Query: 507  AEELGEDSAASLSL---QLSLQREQAPSPP--------------AACEKGKEQHSQAEE- 548
              +  E +     L   +L  QR+ A                  A  E+G++Q    EE 
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1762

Query: 549  ----------LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA 598
                          ++E E    KV       ++ + R+ E      + S+  L+A    
Sbjct: 1763 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1822

Query: 599  VAQVLEQDQR-HLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSS---LRERLQKA 654
              ++ E+  R   L  + ++ +QL E+    +  E  R+  +K  ++     L+   + A
Sbjct: 1823 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIA 1882

Query: 655  IEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASL 714
            ++E+EA    E  +RL+   A  +   +    Q +A+ E  L +LR+  +S+ + ++  +
Sbjct: 1883 LKEKEAE--NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLV 1940

Query: 715  EQKNRQMLEQLKEEIEASEKS-EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAE 773
            E   RQ   Q++EEI A + S E+AA   A      +L  +L   R  A  TL  +  AE
Sbjct: 1941 EDTLRQR-RQVEEEILALKASFEKAAAGKA------ELELELGRIRSNAEDTLRSKEQAE 1993

Query: 774  LERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELS 833
            LE       A+ R++ +  +++ +EA+++    +QK L   E    Q+   +   E   +
Sbjct: 1994 LEA------ARQRQLAAEEERRRREAEER----VQKSLAAEEEAARQRKAALEEVERLKA 2043

Query: 834  SL--LREKRQEVEGEHERRLDKMKEEHQQVM----------AKAREQYEAEERKQRAELL 881
             +   R  R+  E E  R+L   +E  Q+ +           + +EQ   +  +Q   +L
Sbjct: 2044 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2103

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
              L GE E  +RA E E E  R +  +     RR+  E ER  Q  E   + RA+   A 
Sbjct: 2104 DQLRGEAEAARRAAE-EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAA 2162

Query: 942  LALL-EVQEETARR--------EKQQLLDVQ------------RQVALKSEEATATHQQL 980
              L  E ++E ARR         ++Q  D +            RQ A   +E T    QL
Sbjct: 2163 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2222

Query: 981  EEAQKEHTHLLQSNQQL---------------------REILDELQARKLKLESQVDLLQ 1019
            EE   +   L +  Q+L                     R  ++EL   K ++E++   L 
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282

Query: 1020 AQSQQLQKHFSSLEAEAQK----------------------------KQHLLREVTVEEN 1051
             + +   + F   EAE  K                            +Q  L E  ++E 
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342

Query: 1052 ----NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDL---------YLDSLSSHN 1098
                  +   + +  +   +K L   Q + +     Q  + L          L++     
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402

Query: 1099 VWHLLSAEGVALRSAKEFLVQ---QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
            +     AE + LR A+    Q   +  + R R+ A +  ++  R ELA+ ++V      +
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL----V 2458

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPT 1215
            + LE  R+  + +   L E  + + +    L ++E KL QL+S   +    E  L    T
Sbjct: 2459 QTLEIQRQQSDHDAERLREAIAELEREKEKL-QQEAKLLQLKSEEMQTVQQEQLL--QET 2515

Query: 1216 KKAVTFDLSDMDSL 1229
            +      LS+ DSL
Sbjct: 2516 QALQQSFLSEKDSL 2529



 Score =  112 bits (281), Expect = 2e-24
 Identities = 171/751 (22%), Positives = 313/751 (41%), Gaps = 78/751 (10%)

Query: 357  EGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKE-PQLSDSIASDPKSFHGLDFGF 415
            E  R    A++   +   LEE +  A  + +I E + +  + SDS     K         
Sbjct: 1889 ENERLRRLAEDEAFQRRRLEEQA--AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQ 1946

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPL 475
            R ++ E +L +            + +  LG        +++D L+SK+   LE      L
Sbjct: 1947 RRQVEEEILALKASFEKAAAGKAELELELG----RIRSNAEDTLRSKEQAELEAARQRQL 2002

Query: 476  PHEERA------QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQA 529
              EE        +   +SLA EEE  +  +   E  E E L      +  L+   ++E A
Sbjct: 2003 AAEEERRRREAEERVQKSLAAEEEAARQRKAALE--EVERLKAKVEEARRLRERAEQESA 2060

Query: 530  PSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVA--PPEQL 587
                 A E  +++    E+      + ++ E +  +     V  ++R     A    E+ 
Sbjct: 2061 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEA 2120

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLR-------EKLCQEEEEEILRLHQQK 640
             EA ++A  EA     + ++   L+   E+  Q R       EKL +E E+E  R  Q +
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAE 2180

Query: 641  EQSL-----SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA----DEDQIRAE 691
            + +L     +       K   E+  R + +  Q L+ LR Q++ +       DE+  R +
Sbjct: 2181 QAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLK 2240

Query: 692  QEAS-LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ 750
             EA+   + R ++E +  + R  +E+     L +LK  IEA  ++         ++ LQ+
Sbjct: 2241 AEATEAARQRSQVEEELFSVRVQMEE-----LSKLKARIEAENRALILRDKDNTQRFLQE 2295

Query: 751  LREQLEGERKEAVA-TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQ-----KEE 804
              E+++   +EA   ++  + +A L +L     A+ R +   + K+  +A Q     K E
Sbjct: 2296 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE 2355

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ----EVEGEHERRLDKMKEEHQ- 859
            A+L   L Q +    +++  +   + +++  L E+ Q     +E E +R+L+   E  + 
Sbjct: 2356 AEL---LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412

Query: 860  --QVMAKAREQYEAEERKQRAELLGHLTGE-LERLQRAHERE------LETVRQEQHKRL 910
              +V   +R Q  AEE  QR        GE L R + A + +      LE  RQ+     
Sbjct: 2413 KLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDA 2472

Query: 911  EDLRRRHREQERKLQDLELD---LETRAKD---VKARLALLEVQ--EETARREKQQLLDV 962
            E LR    E ER+ + L+ +   L+ ++++   V+    L E Q  +++   EK  LL  
Sbjct: 2473 ERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQR 2532

Query: 963  QRQVA--------LKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            +R +         L  +E     Q  EE Q++   + Q  Q+L   ++E + R+ + E  
Sbjct: 2533 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEG 2592

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLRE 1045
            V   Q + QQL++     E    ++   LRE
Sbjct: 2593 VRRKQEELQQLEQQRRQQEELLAEENQRLRE 2623



 Score =  112 bits (279), Expect = 3e-24
 Identities = 178/818 (21%), Positives = 340/818 (41%), Gaps = 84/818 (10%)

Query: 208  ALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNL---------HLDIGALGGDFEYEESL 258
            A  L  +GE T  + E E   +   + +E LR L          L+  A     + EE L
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 1922

Query: 259  ----RTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLS-SAVGK-------GRQGSGA 306
                + S  E ++   L  D        +       +S   +A GK       GR  S A
Sbjct: 1923 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1982

Query: 307  RPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAK 366
               L  KE+ E    +  R L   +      E  +   +E  + ++ A EE +R+ +AA 
Sbjct: 1983 EDTLRSKEQAELEAARQ-RQLAAEE------ERRRREAEERVQKSLAAEEEAARQRKAAL 2035

Query: 367  EPKKKASAL--------EEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR 418
            E  ++  A         E    +++++L++++   + +L     +   +    +   +  
Sbjct: 2036 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2095

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
            + +    +D L      A R A++      + + +++Q   Q ++++ L++         
Sbjct: 2096 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQAR 2155

Query: 479  ERAQSPPRSLATEEEPPQGPEGQPEW-----KEAEELGEDSAASLSLQLSLQREQAPSPP 533
             +AQ+    L  E E       Q E      K+A +   +     + Q   Q+ Q     
Sbjct: 2156 AQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2215

Query: 534  AACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALK 593
                   E+    + L   + +    E   A      V  E+ S       E+LS+   +
Sbjct: 2216 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR--VQMEELSKLKAR 2273

Query: 594  AMEEAVAQVL--EQDQRHLLESKQEKMQQLREKLCQEE--EEEILRLHQQKEQSLSSLRE 649
               E  A +L  + + +  L+ + EKM+Q+ E+  +     +E  RL Q  E+ L+  R 
Sbjct: 2274 IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2333

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
              +K ++E+   +  +E+ RL      +Q   +  ++Q R  QE   Q  ++  E  Q  
Sbjct: 2334 LAEKMLKEKMQAV--QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2391

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE--GER--KEAVAT 765
            +R    ++ RQ+    + E      +E +   A  E+  Q+ R+Q E  GE+  +  +AT
Sbjct: 2392 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451

Query: 766  LEKE---HSAELERLCSSLEAKH-REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQK 821
             EK     + E++R  S  +A+  RE ++ L+++ ++ QQ  EA+L +   +    V Q+
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQE 2509

Query: 822  SYHVAGYEHELSSLLREKRQEVEGEH--ERRLDKMKEEHQQVMAKAREQYEAEERKQRAE 879
               +   +    S L EK   ++ E   E+   K+++  Q  +AKA++  E ++R+Q+  
Sbjct: 2510 QL-LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ-- 2566

Query: 880  LLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVK 939
                   ++E+ ++     +E  R+ QH+  E +RR+  E ++        LE + +  +
Sbjct: 2567 -------QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ--------LEQQRRQQE 2611

Query: 940  ARLALLEVQEETARREKQQLLDVQRQVAL-KSEEATAT 976
              LA    +E    RE+ QLL+ Q + AL  SEE TA+
Sbjct: 2612 ELLA----EENQRLREQLQLLEEQHRAALAHSEEVTAS 2645



 Score =  107 bits (267), Expect = 8e-23
 Identities = 177/723 (24%), Positives = 318/723 (43%), Gaps = 120/723 (16%)

Query: 589  EAAL---KAMEEAVAQVLEQDQRHLLESKQEKMQQL--REKLC---QEEEEEILR-LHQQ 639
            EAAL   + + EA AQ   Q +R   E +Q   +++  RE+     Q+++  I   L Q 
Sbjct: 1393 EAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1452

Query: 640  KEQSLSSLRERLQKAIEEEEARMREEESQR-------------------LSWLRAQVQSS 680
            ++ S + ++ + ++A   E +R+R EE  R                   L  LRA+ + +
Sbjct: 1453 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1512

Query: 681  ------TQADEDQIRAEQEASLQKLRE---ELESQQKAERASLEQKNR--QMLEQLKEEI 729
                   Q + +++R + +   Q+ R+   EL S+ KAE  +  +K R  Q LE+L+ + 
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1572

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEA 783
            E +E+     L  A+ +  +Q++  LE  ++ A A L+       E +A+LER   SL+ 
Sbjct: 1573 EEAER----RLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER---SLQE 1625

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVE-----------HRVHQKSYHVAGYEHEL 832
            +H  V    ++  + AQQ+ EA+  +   + E            R+  ++  VA  +   
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1685

Query: 833  SSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAE--LLGHLTGELER 890
             +   ++++E E E  RR    K E Q V  +   + E E+++Q AE      L  E E 
Sbjct: 1686 QAEAEKQKEEAEREARRR---GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742

Query: 891  LQ-RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQE 949
            ++ RA   + E  RQ   + L  L+R      +K Q+LE +L     +++  LA     E
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1802

Query: 950  E----TARREKQQLLDVQRQVALKSEEATATHQQLEEAQK-----EHTHLLQSNQQLREI 1000
            E    T+ + KQ+L     +    +EEA       EEA++     E     Q  +  R +
Sbjct: 1803 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1862

Query: 1001 LDEL----QARKLKLESQVDL--LQAQSQQLQK-----HFSSLEAEAQKKQHLLREVTVE 1049
             ++L    +A +LK E+++ L   +A++++L++      F     E Q  QH   +  +E
Sbjct: 1863 AEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH---KADIE 1919

Query: 1050 ENNASPHFEPDLHIEDLRKSL------GTNQTKEVSSSLSQSKE---------DLYLDSL 1094
            E  A      D  +E  +K L         Q +E   +L  S E         +L L  +
Sbjct: 1920 ERLAQLRKASDSELE-RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1978

Query: 1095 SSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR------QTALKAAQQHWRHELASAQEV 1148
             S+    L S E   L +A++  +      RRR      Q +L A ++  R   A+ +EV
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038

Query: 1149 AKDPPGIKALEDMRKNLEKET-RHLDEMKSAMRKGHNLLKKK-----EEKLNQLESSLWE 1202
             +    ++    +R+  E+E+ R L   + A +K     +K      ++K  +L+ +L +
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098

Query: 1203 EAS 1205
            E S
Sbjct: 2099 EQS 2101



 Score =  103 bits (256), Expect = 2e-21
 Identities = 184/803 (22%), Positives = 322/803 (40%), Gaps = 149/803 (18%)

Query: 520  LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP-PVSPEVRS- 577
            L+L L +E A        + ++  ++ E LG G        EKV   P P P +P +RS 
Sbjct: 1034 LRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSE 1093

Query: 578  ------------------------TEPVAPPEQLSEAALKAMEEAVAQV---------LE 604
                                       V    Q +E  L+A EE + +          LE
Sbjct: 1094 LELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELE 1153

Query: 605  QDQRHL------LESKQEKMQQLREKL--CQEEEEEILRLHQQKE-------QSLSSLRE 649
              +  L       E++Q     LR++L   QE  E + + H +++       + ++ L E
Sbjct: 1154 ATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE 1213

Query: 650  RLQKAIEEEEARMREEE--SQRLSWLRAQVQ------SSTQADEDQIRAEQEASLQKLRE 701
            R Q  + + + R RE E   ++L + R             +  ++QI+A   A  Q +RE
Sbjct: 1214 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1273

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ------QLREQL 755
            +L    + E+A LE+     +E+  E++E  ++  +  +NA K+  LQ      QL    
Sbjct: 1274 QL----RQEQALLEE-----IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1324

Query: 756  EGERKEAVATLE----------KEHSAELERLCSSLEAKHREVVSSL--QKKIQEAQQKE 803
               +K  V +            + H +EL  L S       E +  +  ++++ E Q+ E
Sbjct: 1325 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1384

Query: 804  E----AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLD------K 853
            E    A+++  L +        +   A  E E   L +  ++EV    E  +D       
Sbjct: 1385 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1444

Query: 854  MKEEHQQ--------VMAKAREQYEAEERKQRAE---------------LLGHLTGELER 890
            ++EE QQ        + AKAR+   AE  + R E                 G   GEL+ 
Sbjct: 1445 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1504

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            L RA   E E  +++  +  E LRR+ +++ ++ +  E++L +R K            E 
Sbjct: 1505 L-RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK-----------AEA 1552

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK 1010
             A REKQ+ L    ++ L++EEA    +Q E  +     +     Q R    ELQ+++  
Sbjct: 1553 EAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ-RSAEAELQSKRAS 1611

Query: 1011 LESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSL 1070
               +   L+   Q+     + L  EA+++     +   E   A    E +L    L+ + 
Sbjct: 1612 FAEKTAQLERSLQEEHVAVAQLREEAERR----AQQQAEAERAREEAERELERWQLKANE 1667

Query: 1071 GTN---QTKEVS--SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMR 1125
                  Q +EV+   SL+Q++ +   +  +         AE  A+R  +E   Q+    +
Sbjct: 1668 ALRLRLQAEEVAQQKSLAQAEAEKQKEE-AEREARRRGKAEEQAVRQ-RELAEQELE--K 1723

Query: 1126 RRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLD-EMKSAMRKGHN 1184
            +RQ A   AQQ     LA+ QE+ +     +  E  R+ LE+E   L  E  +A +K   
Sbjct: 1724 QRQLAEGTAQQ----RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQE 1779

Query: 1185 LLKKKEEKLNQLESSLWEEASDE 1207
            L  +  +   ++E  L  +A  E
Sbjct: 1780 LEAELAKVRAEMEVLLASKARAE 1802



 Score = 68.6 bits (166), Expect = 4e-11
 Identities = 127/556 (22%), Positives = 230/556 (41%), Gaps = 87/556 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            E++   +++ +     +  +A+   +  A+A E+ A      A  E  + ++ A++  ++
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQA-EQAALRQKQAADAEMEKHKKFAEQTLRQ 2207

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
             + +E+  +    +LE ++H K   L D      K+        RS++ E L  V V   
Sbjct: 2208 KAQVEQELTTLRLQLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2265

Query: 432  VLG---GACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
             L           + L + DKD++Q    E   K  +  EE     +  +E A+   R L
Sbjct: 2266 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL--RQL 2323

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSL---QREQAPSPPAACEKGKEQHSQ 545
            A E+   Q    +   KE  +  ++ A  L  +  L   Q+E A       ++ KEQ +Q
Sbjct: 2324 AEEDLAQQRALAEKMLKEKMQAVQE-ATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQ 2382

Query: 546  --AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEA----- 598
              AEE    Q   E   ++           ++R  E      +  E A +  ++A     
Sbjct: 2383 QLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGE 2442

Query: 599  --------------VAQVLE---QDQRHLLESKQEKMQQL---REKLCQE---------- 628
                          + Q LE   Q   H  E  +E + +L   +EKL QE          
Sbjct: 2443 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2502

Query: 629  ----EEEEILRLHQQKEQSLSSLRERL---QKAIEEEEARMRE---EESQRLSWLRAQVQ 678
                ++E++L+  Q  +QS  S ++ L   ++ IE+E+A++ +   +E  +   LR + Q
Sbjct: 2503 MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQ 2562

Query: 679  SSTQADEDQIRAEQEASLQKLR------EELESQQKAERASLEQKNRQMLE-------QL 725
               Q  E + R    AS+++ R      EE   +++ E   LEQ+ RQ  E       +L
Sbjct: 2563 RQQQQMEQE-RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL 2621

Query: 726  KEEIEASEKSEQAALNAAKE---------KALQQLREQLEGERKEAVATLEKEHSAE-LE 775
            +E+++  E+  +AAL  ++E         K L   R+ L+G   EA    E EHS + L 
Sbjct: 2622 REQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEA----EPEHSFDGLR 2677

Query: 776  RLCSSLEAKHREVVSS 791
            R  S+   +   ++S+
Sbjct: 2678 RKVSAQRLQEAGILSA 2693



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 132/618 (21%), Positives = 250/618 (40%), Gaps = 98/618 (15%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            Q L+  +    E    ++ +L E+L     E  LRL    +  +++   ++ +   +   
Sbjct: 484  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL----KAGVAAPATQVAQVTLQSVQ 539

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR---AEQEASLQKLREELESQQKAERASLEQK 717
            R  E E   L +L+  +      +E+Q R   AE    L  +  +L S +          
Sbjct: 540  RRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH------- 589

Query: 718  NRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERL 777
              Q +E+ + +IE + +S++  L+ A   A +    +L+ +     A L     A L   
Sbjct: 590  --QSIEEFRAKIERA-RSDEGQLSPATRGAYRDCLGRLDLQ----YAKLLNSSKARLR-- 640

Query: 778  CSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLR 837
              SLE+ H   V++  K++    +KEE ++          +  K    +    EL   L+
Sbjct: 641  --SLESLH-SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE--LK 695

Query: 838  EKR-QEVEGEHERRLDKMKEEH------QQVMAKAREQY----------EAEERKQRAEL 880
            EK+ +E++   +R L   +E+H      +   A  + Q+          EA  ++  A  
Sbjct: 696  EKKIKELQNAGDRLL---REDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYF 752

Query: 881  -----LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
                 +    G+L++LQ A  R+    R     RLEDL +  ++++ +L + +  L   A
Sbjct: 753  QFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 812

Query: 936  KDVKARLALLEVQEETARREKQQLLDV--QRQVAL---KSEEATATHQQLEEAQKEHTHL 990
            K  KA + L         R +  LL V   +QV +   K +E     Q +  AQ  H  +
Sbjct: 813  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDEC----QLVGPAQPSHWKV 868

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEE 1050
            L S+             +  + S   L+   +Q+ Q+  + LEA+ Q    L  ++ V+ 
Sbjct: 869  LSSS-----------GSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDM 917

Query: 1051 NNASPHFEPDLHIEDLRKSLGTNQTKEVSS--SLSQSKEDLYLDSLSSHNVWHLLSAEGV 1108
             +        L  + LR+ +   ++  +++  +L   ++   L SL  H    L  ++  
Sbjct: 918  KSL-------LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970

Query: 1109 ALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELAS----AQEVAKDPPGIKALEDMRKN 1164
                 ++      R M  R+    +   H++  L S    AQE ++    I  L+D+R  
Sbjct: 971  GGFGPED------RLMAEREYG--SCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQ 1022

Query: 1165 LEK-ETRHLDEMKSAMRK 1181
            LE  ETR +  ++  + K
Sbjct: 1023 LEACETRTVHRLRLPLDK 1040


>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
            sapiens]
          Length = 1983

 Score =  130 bits (328), Expect = 7e-30
 Identities = 224/925 (24%), Positives = 398/925 (43%), Gaps = 124/925 (13%)

Query: 340  AKAS-EKEAPEDTV-DAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQL 397
            AKA  EK+A E+ V +  EE +  +E+     K+  AL+E    A  +L+  E       
Sbjct: 1011 AKAEKEKQATENKVKNLTEEMAALDESVARLTKEKKALQEAHQQALGDLQAEE------- 1063

Query: 398  SDSIASDPKSFHGLDFGFRSRISEHLLDVDVL---SPVLGGACRQAQQPLGIEDKDDSQS 454
             D +++  K+        + R+ + + D++        L     +A++ L  + K   +S
Sbjct: 1064 -DRVSALTKA--------KLRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQES 1114

Query: 455  SQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDS 514
              D  Q KQ   LEE+L      ++ ++    SL  E+E   G + Q + KE +   E+ 
Sbjct: 1115 VADAAQDKQQ--LEEKLK-----KKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAEE- 1166

Query: 515  AASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPE 574
                 L+  L+ E+A    A     K++   A EL   +E +E  EE    S        
Sbjct: 1167 -----LEEELEAERA----ARARVEKQRAEAAREL---EELSERLEEAGGASAGQREGCR 1214

Query: 575  VRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH---LLESKQEKMQQLREKLCQEEEE 631
             R  E      +L EAAL+   EA    L + Q      L  + + +Q++R+KL +E+ E
Sbjct: 1215 KREAELGRLRRELEEAALR--HEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSE 1272

Query: 632  -----EILRLHQQKEQSLSSLRERLQKAIEEE--EARMREEESQRLSWLRAQVQSSTQAD 684
                 + L  + +      +  E+L +  E++  EA+++ EE QR         +STQ  
Sbjct: 1273 LRMEVDDLAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQR-----QLADASTQRG 1327

Query: 685  EDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK 744
              Q  + + + L + +E L SQ    +A   Q   ++  QL+EE +A  KS  A    A 
Sbjct: 1328 RLQTESGELSRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKA--KSALAHAVQAL 1385

Query: 745  EKALQQLREQLEGERKEAVATLEK---EHSAELERLCSSLEA-------KHREVVSSLQK 794
                  LREQ E E  EA A L++   + +AE+ +  S  EA       +  E    L  
Sbjct: 1386 RHDCDLLREQHE-EEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLAL 1444

Query: 795  KIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG---EHERRL 851
            ++QEA++  EA   KC    + ++  ++      E E  +L  E+         + +R L
Sbjct: 1445 RLQEAEEGVEAANAKCSSLEKAKLRLQT------ESEDVTLELERATSAAAALDKKQRHL 1498

Query: 852  DKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE---TVRQEQ-- 906
            ++  EE ++   + + + EA +R+ R      L  EL RL+  HE  LE   T+++E   
Sbjct: 1499 ERALEERRRQEEEMQRELEAAQRESRG-----LGTELFRLRHGHEEALEALETLKRENKN 1553

Query: 907  -HKRLEDLRRRHREQERKLQDLELD---LETRAKDVKARL----ALLEVQEETARREKQQ 958
              + + DL  +     + +Q+LE     LE    +++A L      LE++E    R + +
Sbjct: 1554 LQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLE 1613

Query: 959  L----LDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ 1014
            L     +V R++A K EE     +  + A +     L +  + R   +E    K K+E  
Sbjct: 1614 LSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRAR---NEALRLKKKMEGD 1670

Query: 1015 VDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTV---EENNASPHFEPDLHIEDLRKSLG 1071
            ++ L+ Q     +  +  +A  +  Q  L+E      EE   +          + R SL 
Sbjct: 1671 LNDLELQLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLL 1730

Query: 1072 TNQTKEVSSSLSQSKEDLYL---DSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSM---- 1124
              + +E+ ++L Q +    L   + L +    +LL ++   L + K+ L      +    
Sbjct: 1731 AAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEV 1790

Query: 1125 ----RRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHL-----DEM 1175
                + R+ A + A++        A+E+ K+      LE M+K LE+  R L     +  
Sbjct: 1791 EEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEAE 1850

Query: 1176 KSAMRKGHNLLKKKEEKLNQLESSL 1200
            ++A+R G   ++K E K+ +LE+ L
Sbjct: 1851 QAALRGGKKQVQKLEAKVRELEAEL 1875



 Score =  113 bits (283), Expect = 1e-24
 Identities = 179/745 (24%), Positives = 303/745 (40%), Gaps = 121/745 (16%)

Query: 589  EAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKE-QSLSSL 647
            E  LK  +E+VA    QD++ L E  ++K  +L +   + E+E++L    QK+ + L + 
Sbjct: 1105 EGDLKLTQESVADA-AQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQAR 1163

Query: 648  RERLQKAIEEEEA------RMREEESQRLSWLRAQVQSSTQADEDQIRA--EQEASLQKL 699
             E L++ +E E A      + R E ++ L  L  +++ +  A   Q     ++EA L +L
Sbjct: 1164 AEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRL 1223

Query: 700  REELES---QQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE 756
            R ELE    + +A  A+L +K  +   +L E++++ ++  Q       EK   +LR +++
Sbjct: 1224 RRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKL-----EKEKSELRMEVD 1278

Query: 757  GERKEAVATLEKEHSAELERLCSSLEAKHREV---VSSLQKKIQEAQ------QKEEAQL 807
             +    V TL +   A  E+LC + E +  E    V  LQ+++ +A       Q E  +L
Sbjct: 1279 -DLAANVETLTRA-KASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGEL 1336

Query: 808  QKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKARE 867
             + L + E  + Q S   A     L  L R+  +E + +           H   + + + 
Sbjct: 1337 SRLLEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQH 1396

Query: 868  QYEAEERKQRAELLGHLTGELERLQRAHE-------RELETVRQEQHKRLEDLRRRHREQ 920
            + EAE + +   LL     E+ + +  +E        ELE  +++   RL++        
Sbjct: 1397 EEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGVEAA 1456

Query: 921  ERKLQDLE---LDLETRAKDVKARL-------ALLEVQ----EETARREKQQLLDVQRQV 966
              K   LE   L L+T ++DV   L       A L+ +    E      ++Q  ++QR++
Sbjct: 1457 NAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQREL 1516

Query: 967  ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQ 1026
                 E+     +L   +  H   L++ + L+     LQ     L  QV L     Q+L+
Sbjct: 1517 EAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELE 1576

Query: 1027 KHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIED---LRKSLGTNQTK-EVSSSL 1082
            K   +LE E  + Q  L E            E  L +E+   LR  L  +Q K EV   L
Sbjct: 1577 KTKKALEGEKSEIQAALEEA-----------EGALELEETKTLRIQLELSQVKAEVDRKL 1625

Query: 1083 SQSKEDL---------YLDSLSSHNVWHLLSAEGVALRSAKEF----------LVQQTRS 1123
            ++  E+           ++SL + ++     A   ALR  K+           L   TR 
Sbjct: 1626 AEKDEECANLRRNHQRAVESLQA-SLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQ 1684

Query: 1124 MRRRQTALKAAQQHWRHELASAQE----VAKDPPGIKALEDMRKNLEKETRHLDEMKSAM 1179
                Q A +  Q   + E A   E     A+     +ALE     L  E   L+E+++A+
Sbjct: 1685 ATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAE---LEELRAAL 1741

Query: 1180 RKGH-----------------NLL-----------KKKEEKLNQLESSLWEEASDEGTLG 1211
             +G                  NLL           KK E  L QL   + EEA+ E    
Sbjct: 1742 EQGERSRRLAEQELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEV-EEAAQERREA 1800

Query: 1212 GSPTKKAVTFDLSDMDSLSSESSES 1236
                KKA+T      + L  E   S
Sbjct: 1801 EEKAKKAITDAAMMAEELKKEQDTS 1825



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 170/739 (23%), Positives = 316/739 (42%), Gaps = 118/739 (15%)

Query: 540  KEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAV 599
            +E++  A +L   Q+   D EE+  +     V  E +  E       LSE  L+  EE  
Sbjct: 931  QEKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEGKVKE-------LSER-LEDEEEVN 982

Query: 600  AQVLEQDQRHLLESK----QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAI 655
            A +  +  R  LE +    ++ +  L+  L + E+E+     Q  E  + +L E +  A+
Sbjct: 983  ADLAAR--RRKLEDECTELKKDIDDLKLTLAKAEKEK-----QATENKVKNLTEEMA-AL 1034

Query: 656  EEEEARMREEESQRLSWLRAQVQSSTQADEDQI--------RAEQEASLQKLREELESQQ 707
            +E  AR+ +E+ + L     Q     QA+ED++        R EQ+       E+LE   
Sbjct: 1035 DESVARLTKEK-KALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQV------EDLECSL 1087

Query: 708  KAERASLEQKNRQMLEQLKEEIEASEK-SEQAALNAAKEKALQQLREQLEGERKEAVATL 766
            + E+     K R   E+ K ++E   K ++++  +AA++K  QQL E+L           
Sbjct: 1088 EQEK-----KLRMDTERAKRKLEGDLKLTQESVADAAQDK--QQLEEKL----------- 1129

Query: 767  EKEHSAELERLCSSLEAKHREVV-SSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHV 825
             K+  +EL +L  SL  +  +++ + +QKKI+E Q + E +L++                
Sbjct: 1130 -KKKDSELSQL--SLRVEDEQLLGAQMQKKIKELQARAE-ELEE---------------- 1169

Query: 826  AGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLT 885
               E E     R + ++   E  R L+++ E  ++    +  Q E   RK+ AE LG L 
Sbjct: 1170 ---ELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREG-CRKREAE-LGRLR 1224

Query: 886  GELERLQRAHERELETVRQEQ-------HKRLEDLRRRHREQERKLQDLELDLETRAKDV 938
             ELE     HE  +  +R++Q        ++++ L+R  ++ E++  +L ++++  A +V
Sbjct: 1225 RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANV 1284

Query: 939  KARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLR 998
            +         E+  R  + QL + + +V     +      Q    Q E   L +  ++  
Sbjct: 1285 ETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRLLEEKE 1344

Query: 999  EILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQH---LLREVTVEENNASP 1055
             ++ +L   K      ++ L+ Q ++  K  S+L    Q  +H   LLRE   EE  A  
Sbjct: 1345 CLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHDCDLLREQHEEEAEAQA 1404

Query: 1056 HFE-----PDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVAL 1110
              +      +  +   R     +  +  +  L ++K+ L L    +       +A+  +L
Sbjct: 1405 ELQRLLSKANAEVAQWRSKYEADAIQR-TEELEEAKKKLALRLQEAEEGVEAANAKCSSL 1463

Query: 1111 RSAKEFLVQQ----TRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLE 1166
              AK  L  +    T  + R  +A  A  +  RH   + +E  +        E+M++ LE
Sbjct: 1464 EKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQE------EEMQRELE 1517

Query: 1167 ---KETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEAS---DEGTLGG------SP 1214
               +E+R L      +R GH    +  E L +   +L EE S   D+ +L G        
Sbjct: 1518 AAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEK 1577

Query: 1215 TKKAVTFDLSDMDSLSSES 1233
            TKKA+  + S++ +   E+
Sbjct: 1578 TKKALEGEKSEIQAALEEA 1596



 Score = 92.0 bits (227), Expect = 4e-18
 Identities = 131/607 (21%), Positives = 268/607 (44%), Gaps = 56/607 (9%)

Query: 447  EDKDDSQSSQDELQSKQSKGLEERL-------SPPLPHEERAQSPPRSLATE-EEPPQGP 498
            E  ++   +Q ELQ   SK   E         +  +   E  +   + LA   +E  +G 
Sbjct: 1394 EQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV 1453

Query: 499  EGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAED 558
            E       + E  +    + S  ++L+ E+A S  AA +K +    +A E    QEE   
Sbjct: 1454 EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQ 1513

Query: 559  PEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKM 618
             E + A   +  +  E+             E AL+A+E      L+++ ++L E   +  
Sbjct: 1514 RELEAAQRESRGLGTELFRLR------HGHEEALEALE-----TLKRENKNLQEEISDLT 1562

Query: 619  QQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQ------RLSW 672
             Q+   L  +  +E+    ++ +++L   +  +Q A+EE E  +  EE++       LS 
Sbjct: 1563 DQV--SLSGKSIQEL----EKTKKALEGEKSEIQAALEEAEGALELEETKTLRIQLELSQ 1616

Query: 673  LRAQVQSS-TQADED--QIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEI 729
            ++A+V     + DE+   +R   + +++ L+  L+++ +A   +L  K +   +    E+
Sbjct: 1617 VKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLEL 1676

Query: 730  EASEKSEQAALNAAKEKALQ-QLREQLEGERKEAVATLEKEHSAE-LERLCSSLEAKHRE 787
            +    + QA    A  + +Q QL+E+  G  +E     E    A+ LER  S L A+  E
Sbjct: 1677 QLGHATRQATEAQAATRLMQAQLKEEQAGRDEEQRLAAELHEQAQALERRASLLAAELEE 1736

Query: 788  VVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEH 847
            + ++L++  +  +  E+  L+    +  + +H ++  +   + +L + L +   EVE   
Sbjct: 1737 LRAALEQGERSRRLAEQELLEAT--ERLNLLHSQNTGLLNQKKKLEADLAQLSGEVE--- 1791

Query: 848  ERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHE---RELETVRQ 904
            E   ++ + E +   A       AEE K+  +   HL    ER+++  E   REL+   +
Sbjct: 1792 EAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHL----ERMKKTLEQTVRELQARLE 1847

Query: 905  E-QHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEET-------ARREK 956
            E +   L   +++ ++ E K+++LE +L+   K     L  +   E         A  ++
Sbjct: 1848 EAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDR 1907

Query: 957  QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVD 1016
            + L  +Q  V     +  +  +Q EEA+++    L   ++ +  LD+ + R    E+Q +
Sbjct: 1908 KNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAEERADMAETQAN 1967

Query: 1017 LLQAQSQ 1023
             L+A+++
Sbjct: 1968 KLRARTR 1974



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 186/823 (22%), Positives = 322/823 (39%), Gaps = 126/823 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGE-EGSRREEAA----K 366
            E+ E E    +  R  V  +      E  + SE+        AG+ EG R+ EA     +
Sbjct: 1165 EELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAELGRLR 1224

Query: 367  EPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDV 426
               ++A+   E +  A +  +     +  +  DS+    +         R  + +   +V
Sbjct: 1225 RELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDDLAANV 1284

Query: 427  DVLSPVLGGA---CRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEER--LSPPLPHEERA 481
            + L+     A   CR  +  L      +++   +ELQ + +    +R  L        R 
Sbjct: 1285 ETLTRAKASAEKLCRTYEDQLS-----EAKIKVEELQRQLADASTQRGRLQTESGELSRL 1339

Query: 482  QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKE 541
                  L ++    +    Q   +   +L E+S A  +L  ++Q  +       C+  +E
Sbjct: 1340 LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQALRHD-----CDLLRE 1394

Query: 542  QHSQ-AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA 600
            QH + AE     Q        +VA   +   +  ++ TE +   ++     L+  EE V 
Sbjct: 1395 QHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEEGV- 1453

Query: 601  QVLEQDQRHLLESKQEKMQQLRE-KLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEE-- 657
                       E+   K   L + KL  + E E + L  ++  S ++  ++ Q+ +E   
Sbjct: 1454 -----------EAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERAL 1502

Query: 658  EEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKL----REELESQQK----A 709
            EE R +EEE QR      +       +  ++R   E +L+ L    RE    Q++     
Sbjct: 1503 EERRRQEEEMQRELEAAQRESRGLGTELFRLRHGHEEALEALETLKRENKNLQEEISDLT 1562

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ-----QLREQLE-------- 756
            ++ SL  K+ Q LE+ K+ +E  +   QAAL  A E AL+      LR QLE        
Sbjct: 1563 DQVSLSGKSIQELEKTKKALEGEKSEIQAALEEA-EGALELEETKTLRIQLELSQVKAEV 1621

Query: 757  ----GERKEAVATLEKEHSAELERLCSSLEA--KHREVVSSLQKKIQ------------E 798
                 E+ E  A L + H   +E L +SL+A  + R     L+KK++             
Sbjct: 1622 DRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLKKKMEGDLNDLELQLGHA 1681

Query: 799  AQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEH 858
             +Q  EAQ    L Q + +  Q        E  L++ L E+ Q +E    RR   +  E 
Sbjct: 1682 TRQATEAQAATRLMQAQLKEEQAG---RDEEQRLAAELHEQAQALE----RRASLLAAEL 1734

Query: 859  QQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAH---------ERELETVRQEQHKR 909
            +++ A A EQ E   R    ELL       ERL   H         +++LE    +    
Sbjct: 1735 EELRA-ALEQGERSRRLAEQELLE----ATERLNLLHSQNTGLLNQKKKLEADLAQLSGE 1789

Query: 910  LEDLRRRHREQERKLQDLELDLETRAKDVK------ARLALLEVQEETARREKQQLLDVQ 963
            +E+  +  RE E K +    D    A+++K      A L  ++   E   RE Q  L+  
Sbjct: 1790 VEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTLEQTVRELQARLEEA 1849

Query: 964  RQVALKS---------EEATATHQQLEEAQKEHTHLLQSNQQLREILDEL-----QARK- 1008
             Q AL+           +      +L+  QK+H   L+  ++    + EL     + RK 
Sbjct: 1850 EQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELAYQAEEDRKN 1909

Query: 1009 -LKLESQVDLLQAQSQQLQKHFSSLEAEA-------QKKQHLL 1043
              +++  VD LQ++ +  ++ F   E +A       +K QH L
Sbjct: 1910 LARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHEL 1952



 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 147/677 (21%), Positives = 272/677 (40%), Gaps = 100/677 (14%)

Query: 290  DSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPE 349
            +S   SA+    Q       L  ++  E++E +     +  KA+   ++     E +A +
Sbjct: 1371 ESKAKSALAHAVQALRHDCDLLREQHEEEAEAQAELQRLLSKANAEVAQWRSKYEADAIQ 1430

Query: 350  DTVDAGEEGSR-------REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIA 402
             T +  E   +        EE  +    K S+LE+       E E      E   S + A
Sbjct: 1431 RTEELEEAKKKLALRLQEAEEGVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAA 1490

Query: 403  SDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQS- 461
             D K  H         + E     + +   L  A R+++  LG E        ++ L++ 
Sbjct: 1491 LDKKQRH-----LERALEERRRQEEEMQRELEAAQRESRG-LGTELFRLRHGHEEALEAL 1544

Query: 462  ----KQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEG--QPEWKEAEELGE-DS 514
                +++K L+E +S        +    + L   ++  +G +   Q   +EAE   E + 
Sbjct: 1545 ETLKRENKNLQEEISDLTDQVSLSGKSIQELEKTKKALEGEKSEIQAALEEAEGALELEE 1604

Query: 515  AASLSLQLSLQREQAPSPPAACEKGKE------QHSQAEELGPGQEEAEDPEEKVAVSPT 568
              +L +QL L + +A       EK +E       H +A E      +AE      A+   
Sbjct: 1605 TKTLRIQLELSQVKAEVDRKLAEKDEECANLRRNHQRAVESLQASLDAETRARNEALRLK 1664

Query: 569  PPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQE 628
              +  ++   E      QL  A  +A E   A  L Q              QL+E+    
Sbjct: 1665 KKMEGDLNDLEL-----QLGHATRQATEAQAATRLMQ-------------AQLKEEQAGR 1706

Query: 629  EEEEIL--RLHQQKEQSLSSLRERLQKAIEEEEARMRE-EESQRLSWLRAQVQSSTQADE 685
            +EE+ L   LH+Q  Q+L      L   +EE  A + + E S+RL            A++
Sbjct: 1707 DEEQRLAAELHEQA-QALERRASLLAAELEELRAALEQGERSRRL------------AEQ 1753

Query: 686  DQIRAEQEASLQKLREE-LESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK 744
            + + A +  +L   +   L +Q+K   A L Q + ++ E  +E  EA EK+++A  +AA 
Sbjct: 1754 ELLEATERLNLLHSQNTGLLNQKKKLEADLAQLSGEVEEAAQERREAEEKAKKAITDAA- 1812

Query: 745  EKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEE 804
                  + E+L+ E+         + SA LER+  +LE   RE+ + L++  Q A +  +
Sbjct: 1813 -----MMAEELKKEQ---------DTSAHLERMKKTLEQTVRELQARLEEAEQAALRGGK 1858

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAK 864
             Q+QK                      L + +RE   E++ E ++  + +K   +     
Sbjct: 1859 KQVQK----------------------LEAKVRELEAELDAEQKKHAEALKGVRKHERRV 1896

Query: 865  AREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKL 924
                Y+AEE ++    +  L  +L+   ++++R+ E   Q+ +  L   R+   E +   
Sbjct: 1897 KELAYQAEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQANTNLAKYRKAQHELDDAE 1956

Query: 925  QDLELDLETRAKDVKAR 941
            +  ++  ET+A  ++AR
Sbjct: 1957 ERADM-AETQANKLRAR 1972



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 121/586 (20%), Positives = 226/586 (38%), Gaps = 76/586 (12%)

Query: 753  EQLEGERKEAVATLEKEHS-AELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCL 811
            E+L  +R   V TL +  S   L RL        R+ + ++Q  I+     +     K  
Sbjct: 823  EELRDQRLAKVLTLLQARSRGRLMRLEYQRLLGGRDALFTIQWNIRAFNAVKNWSWMKLF 882

Query: 812  GQVEH--RVHQKSYHVAGYEHELSSL------LREKRQEVEGEHERRLDKMKEEHQQVMA 863
             +++   R  Q    +A    EL  L         KRQE+E  H     +  +   Q+ A
Sbjct: 883  FKMKPLLRSAQAEEELAALRAELRGLRGALAAAEAKRQELEETHVSITQEKNDLALQLQA 942

Query: 864  KAREQYEAEER-----KQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHR 918
            +     +AEER     K + +L G +    ERL+   E E+            DL  R R
Sbjct: 943  EQDNLADAEERCHLLIKSKVQLEGKVKELSERLE--DEEEVNA----------DLAARRR 990

Query: 919  EQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            + E +  +L+ D++    D+K  LA  E +++    + + L +   ++A   E      +
Sbjct: 991  KLEDECTELKKDID----DLKLTLAKAEKEKQATENKVKNLTE---EMAALDESVARLTK 1043

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQ-------------- 1024
            + +  Q+ H   L   Q   + +  L   KL+LE QV+ L+   +Q              
Sbjct: 1044 EKKALQEAHQQALGDLQAEEDRVSALTKAKLRLEQQVEDLECSLEQEKKLRMDTERAKRK 1103

Query: 1025 ----LQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGT---NQTKE 1077
                L+    S+   AQ KQ L  ++  +++  S   +  L +ED  + LG     + KE
Sbjct: 1104 LEGDLKLTQESVADAAQDKQQLEEKLKKKDSELS---QLSLRVED-EQLLGAQMQKKIKE 1159

Query: 1078 VSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQ-------QTRSMRRRQTA 1130
            + +   + +E+L  +  +   V    +     L    E L +       Q    R+R+  
Sbjct: 1160 LQARAEELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKREAE 1219

Query: 1131 L-----KAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNL 1185
            L     +  +   RHE   A    K   G   L +   +L++  + L++ KS +R   + 
Sbjct: 1220 LGRLRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELRMEVDD 1279

Query: 1186 LKKKEEKLNQLESS------LWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSP 1239
            L    E L + ++S       +E+   E  +     ++ +    +    L +ES E    
Sbjct: 1280 LAANVETLTRAKASAEKLCRTYEDQLSEAKIKVEELQRQLADASTQRGRLQTESGELSRL 1339

Query: 1240 PHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQLSSVLSILDSL 1285
               +     ++    +L ++ +  L   L + S   S++   + +L
Sbjct: 1340 LEEKECLISQLSRGKALAAQSLEELRRQLEEESKAKSALAHAVQAL 1385


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score =  130 bits (326), Expect = 1e-29
 Identities = 209/890 (23%), Positives = 380/890 (42%), Gaps = 108/890 (12%)

Query: 364  AAKEPKKKASALEEGSS--DASQELEISEHMKEPQLSDSIASDPKSFHGLD---FGFRSR 418
            A ++P  +A A  + +S   A Q+   S     P+LS    S P S  GL+    G RS 
Sbjct: 1168 AEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAP-SVWGLEPDQNGARSL 1226

Query: 419  ISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHE 478
                 L   + +  +  A  +  Q L       +Q ++D L+ +  K LEERL+     +
Sbjct: 1227 FKRGPLLTALSAEAVASALHKLHQDLW-----KTQQTRDVLRDQVQK-LEERLTDTEAEK 1280

Query: 479  ERA----QSPPRSLATEEEPPQGPEGQPEWKEAEELG-EDSAASLSLQL---SLQREQAP 530
             +     Q   R L+  +E     EG+    E+E +   ++ ASL  +L    LQR +A 
Sbjct: 1281 SQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQ 1340

Query: 531  SPPAACEKGKEQ-HSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSE 589
                  +  KE   +Q E L     +A   E +   S    +  ++R+          + 
Sbjct: 1341 GERELLQAAKENLTAQVEHL-----QAAVVEARAQASAAGILEEDLRT----------AR 1385

Query: 590  AALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRE 649
            +ALK   E V    E+++   L+ +Q +++  + K  QE    + +   ++E+ + +LR 
Sbjct: 1386 SALKLKNEEVES--ERERAQALQ-EQGELKVAQGKALQENLALLTQTLAEREEEVETLRG 1442

Query: 650  RLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKA 709
            ++Q     E  + RE +   L  L   ++   Q  E  ++ EQ   L+K R  LE    A
Sbjct: 1443 QIQ-----ELEKQREMQKAALELLSLDLKKRNQ--EVDLQQEQIQELEKCRSVLEHLPMA 1495

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ-QLREQLEGERKEAVATLEK 768
                  Q+  Q L   +E+I   EK  +   N  + + L+ + ++Q+   ++  V  L+K
Sbjct: 1496 V-----QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKK 1550

Query: 769  EHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGY 828
            +    LE L   LE  H ++    QK I+E + + E Q +  L  +   + ++S  +   
Sbjct: 1551 Q-LVTLECLALELEENHHKMECQ-QKLIKELEGQRETQ-RVALTHLTLDLEERSQELQAQ 1607

Query: 829  EHELSSL----------LREKRQEVEGEHER--RLDKMKE---------EHQQVMAKARE 867
              ++  L          L+E+ QEV+ + E+   L + KE         + + ++ K R 
Sbjct: 1608 SSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERI 1667

Query: 868  QYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDL 927
            Q   ++R ++ ++L     +++   R   REL T RQ   +R E+ +   + Q   L+ +
Sbjct: 1668 QVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHM 1727

Query: 928  ELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQV-------ALKSEEATATHQQL 980
            +L L  + K+V+ +   +   +E   + +QQL  + R+V       + + +E     QQL
Sbjct: 1728 KLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQL 1787

Query: 981  EEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040
            +EA+++        Q L+  LDE Q    + + +++ LQ + QQ Q     ++ +A   Q
Sbjct: 1788 QEAREQGE---LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQ 1844

Query: 1041 HLLRE--VTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHN 1098
              L +  +T++E     H E   H E  R+     +   V     Q+ E++  D      
Sbjct: 1845 GALEQAHMTLKER----HGELQDHKEQARR---LEEELAVEGRRVQALEEVLGD------ 1891

Query: 1099 VWHLLSAEGVALRSAKEFLVQQ-TRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKA 1157
                L AE      A   L QQ     +  +   +A Q  W    A  +E  ++   ++A
Sbjct: 1892 ----LRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947

Query: 1158 LEDMRKNLEKETR-HLDEMKSAMRKGHNLLKKKEEK-LNQLESSLWEEAS 1205
                 ++ E+  R   + ++ A+ K H  L+ KE+  L Q E S   EAS
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAS 1997



 Score =  127 bits (319), Expect = 8e-29
 Identities = 210/860 (24%), Positives = 369/860 (42%), Gaps = 147/860 (17%)

Query: 438  RQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQG 497
            +Q +  L + +++  Q     L++KQS+ L E ++  L     +      L  +E     
Sbjct: 510  QQEELHLAVRERERLQEMLMGLEAKQSESLSELIT--LREALESSHLEGELLRQE----- 562

Query: 498  PEGQPEWKEAEELGEDSAASLSL-QLSLQREQAPSPPAACEKGKEQHSQA-EELGPGQEE 555
               Q E   A    E S A LS  + +L+ E A    AA +      + A +++G  Q+ 
Sbjct: 563  ---QTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQL 619

Query: 556  AEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLS------------EAALKAMEEAVAQVL 603
             +  EE  +V      + + R+   V   E               EA L+  EEA A+ L
Sbjct: 620  LQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAE-L 678

Query: 604  EQDQRHLLESKQEKMQQLREKLCQEEEE--EILRLHQQKEQSLSSLRERLQKAIEEEEAR 661
            + D R + E K+E  ++L E   Q+E    ++ +LHQ+ ++      E L +A++E+EA 
Sbjct: 679  QADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQ----EEVLARAVQEKEAL 734

Query: 662  MREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQ--QKAERASLEQKNR 719
            +RE+ +     L  ++Q+  +  +D   AEQ   L   +E LES   +  ++ S+ +  +
Sbjct: 735  VREKAA-----LEVRLQAVERDRQDL--AEQLQGLSSAKELLESSLFEAQQQNSVIEVTK 787

Query: 720  QMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEA---VATLEKEHSAELER 776
              LE   + +  +++  Q  +   K + L   R Q E ER  A   +A  E+E    LE+
Sbjct: 788  GQLEVQIQTVTQAKEVIQGEVRCLKLE-LDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846

Query: 777  LCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLL 836
                 +A H + V+ L++K ++ +   + +L K L  +E             + EL   L
Sbjct: 847  Q----KAAHEKEVNQLREKWEKERSWHQQELAKALESLERE-----------KMELEMRL 891

Query: 837  REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHL----------TG 886
            +E++ E+E      +   +EE +     A  Q + E  K+R  LL  L          + 
Sbjct: 892  KEQQTEMEA-----IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ 946

Query: 887  ELERL------QRAHERE----LETVRQEQHKRLEDLRRRHREQERKLQDL-------EL 929
            +LERL      Q+  E+E    L+T  QE  + L++  R+HR+    LQ+        ++
Sbjct: 947  QLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006

Query: 930  DLETRAKDVKA---------RLALLEVQEETAR------------REK-----------Q 957
            DL+ + +D+K+         RL   EVQE+               REK           Q
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066

Query: 958  QLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQ-VD 1016
            +LL +Q   +++ +E +A  Q ++EAQ E   L    + LR+ + E +A  L  E+Q ++
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE 1126

Query: 1017 LLQAQ---SQQLQKHFSSLEAEAQKKQHLLR------EVTVEENNASPHFEPDLHIEDLR 1067
             L+A     QQL+    + EA+A + Q  LR      E    E       +    +  L 
Sbjct: 1127 ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLY 1186

Query: 1068 KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRR 1127
             +L     ++   S+ +S+ +L     S+ +VW L   +  A    K   +    S    
Sbjct: 1187 SAL-----QQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241

Query: 1128 QTAL-KAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKET----RHLDEMKSAMRKG 1182
             +AL K  Q  W+ +    ++V +D   ++ LE+   + E E       L +++  + + 
Sbjct: 1242 ASALHKLHQDLWKTQ--QTRDVLRDQ--VQKLEERLTDTEAEKSQVHTELQDLQRQLSQN 1297

Query: 1183 HNLLKKKEEKLNQLESSLWE 1202
                 K E K N LES L E
Sbjct: 1298 QEEKSKWEGKQNSLESELME 1317



 Score =  114 bits (284), Expect = 9e-25
 Identities = 182/830 (21%), Positives = 343/830 (41%), Gaps = 101/830 (12%)

Query: 506  EAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAV 565
            + EE  ++  A  S    L+           E+ +E  SQ E++   Q + E   + +  
Sbjct: 1596 DLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL-- 1653

Query: 566  SPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQL--RE 623
                    E R  E +   E++    L+       ++LE+D   +  S +E+ ++L  + 
Sbjct: 1654 --------ERRDQELMLQKERIQ--VLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703

Query: 624  KLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA 683
            +L QE  EE     + +  SL  ++  L+   +E+E   ++E    L  L+ Q++   Q 
Sbjct: 1704 QLMQERAEEGKGPSKAQRGSLEHMKLILRD--KEKEVECQQEHIHELQELKDQLEQQLQG 1761

Query: 684  DEDQI--------RAEQEA-----SLQKLREELESQQKAERASLEQKNRQMLEQLKEEIE 730
               ++        + EQE       LQ+ RE+ E ++++ ++ L++  R  L Q  +E+E
Sbjct: 1762 LHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRA-LAQRDQELE 1820

Query: 731  ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK------EHSAELERLCSSLEAK 784
            A ++ +Q A    +E+ +++  + L+G  ++A  TL++      +H  +  RL   L  +
Sbjct: 1821 ALQQEQQQA--QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVE 1878

Query: 785  HR------EVVSSLQKKIQEAQQKEEAQLQKCLGQV-EHRVHQKSYHVAGYEHELSSLLR 837
             R      EV+  L+ + +E ++   A  Q+C  Q  EH V  ++   +  + +  ++L+
Sbjct: 1879 GRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQ--AVLK 1936

Query: 838  EKRQEVEGEHERRLDKMKEEHQQVMAKARE--------------QYEAEERKQRAELLGH 883
            E+ QE+E     R +     HQ+  A+AR               Q + +   ++AEL   
Sbjct: 1937 ERDQELEA---LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRS 1993

Query: 884  LTGELERLQ------RAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            L      LQ      +AH R+LE   + Q   ++D   R++E  ++LQ      +   + 
Sbjct: 1994 LEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRH 2053

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALK--SEEATATHQQLEEAQKEHTHLLQSNQ 995
             + R  LLE  +  A+R ++ ++  ++ +  +   EE    HQ + E Q       Q   
Sbjct: 2054 QQEREQLLE--KSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEIL 2111

Query: 996  QLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASP 1055
            +LRE         L    +   ++ QS +L      L+ E ++ Q  LR+    E     
Sbjct: 2112 ELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEARE----- 2166

Query: 1056 HFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKE 1115
              E     +DL  SL   QTK   SSL +    L    L   +    L  E    R A E
Sbjct: 2167 -IEWREKAQDLALSLA--QTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALE 2223

Query: 1116 FLVQQTRSMRRRQTALKAAQQHWRHEL--ASAQEVAKDPPGI--KALEDMRKNLEKETRH 1171
               ++  S     TA   ++     +L   S  E    P G+  ++     ++L++    
Sbjct: 2224 --KERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVAR 2281

Query: 1172 LDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS 1231
            L+  +S +++ +  L+   E++ +    L  EA      G     KA     +  D    
Sbjct: 2282 LEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQ 2341

Query: 1232 ESSES-----------FSPPHREWWRQQRID--STPSLTSRKIHGLSHSL 1268
            ++S++                    R+Q+ D  +  + TSR++ GL HSL
Sbjct: 2342 KNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSL 2391



 Score =  112 bits (280), Expect = 3e-24
 Identities = 225/956 (23%), Positives = 389/956 (40%), Gaps = 166/956 (17%)

Query: 362  EEAAKEPKKKASALEEGSS-----------------------DASQEL---EISEHMKEP 395
            +EAA++ +   +AL+E SS                       D SQ L   E+ E ++E 
Sbjct: 981  KEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRET 1040

Query: 396  QLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGI--EDKDDSQ 453
            Q  + I  + +         ++ ++  L++ +    VL  A    QQ L    +D  ++Q
Sbjct: 1041 QEYNRIQKELER-------EKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQ 1093

Query: 454  SSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGED 513
              Q EL S Q + L + +      E+ A    +     EE       + + + +    E 
Sbjct: 1094 GEQKEL-SAQMELLRQEVK-----EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEA 1147

Query: 514  SAASLSLQLSLQREQAPSPPAACEKGKEQHSQAE--ELGPGQEEAEDP--EEKVAVSPTP 569
             AA L L+L     Q  +  A  + G +  +QA+   L    ++A     E +  +S   
Sbjct: 1148 KAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGG 1207

Query: 570  PVSPEVRSTEPVAPPEQLSEAAL--------KAMEEAVAQVLEQDQRHLLESKQ------ 615
              +P V   E    P+Q    +L            EAVA  L +  + L +++Q      
Sbjct: 1208 DSAPSVWGLE----PDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLR 1263

Query: 616  EKMQQLREKLCQEEEE------EILRLHQQ-------------KEQSLSSLRERLQKAIE 656
            +++Q+L E+L   E E      E+  L +Q             K+ SL S    L + + 
Sbjct: 1264 DQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMA 1323

Query: 657  EEEARMREEESQRL------SWLRAQVQSSTQADEDQIRAEQEASLQ-KLREELESQQKA 709
              ++R+R  E QR+        L+A  ++ T   E    A  EA  Q      LE   + 
Sbjct: 1324 SLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRT 1383

Query: 710  ERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQ---LREQLEGERKEAVATL 766
             R++L+ KN + +E  +E  +A +  EQ  L  A+ KALQ+   L  Q   ER+E V TL
Sbjct: 1384 ARSALKLKNEE-VESERERAQALQ--EQGELKVAQGKALQENLALLTQTLAEREEEVETL 1440

Query: 767  EKEHSAELERLCSSLEAKHREVVSSLQKKIQEA--QQKEEAQLQKCLGQVEHRVHQKSYH 824
             +    ELE+     +A    +   L+K+ QE   QQ++  +L+KC   +EH        
Sbjct: 1441 -RGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEH------LP 1493

Query: 825  VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHL 884
            +A  E E   L  ++ Q  E E +R   +   EHQ +  + ++Q    +R Q  +L   L
Sbjct: 1494 MAVQERE-QKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 885  TG----ELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKA 940
                   LE  +  H+ E       Q K +++L  +   Q   L  L LDLE R+++++A
Sbjct: 1553 VTLECLALELEENHHKMEC------QQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606

Query: 941  RLAL---LEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQS---- 993
            + +    LE       RE Q+          + +E  +  +Q+EE Q++  HL Q     
Sbjct: 1607 QSSQIHDLESHSTVLARELQE----------RDQEVKSQREQIEELQRQKEHLTQDLERR 1656

Query: 994  NQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNA 1053
            +Q+L    + +Q  + +   Q  +L+   +Q++        E   ++ L++E   E    
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 1054 SPHFEPDLH-----IEDLRKSLGTNQ-----TKEVSSSLSQSKEDLYLDSLSSHNVWHLL 1103
            S      L      + D  K +   Q      +E+   L Q  + L           H  
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGL-----------HRK 1765

Query: 1104 SAEGVALRSAKE---FLVQQTRSMRRRQTALKAAQQHWRHELASAQE-VAKDPPGIKALE 1159
              E   L S +E    ++QQ     R Q  LK  +Q  + +L  AQ  +A+    ++AL+
Sbjct: 1766 VGETSLLLSQREQEIVVLQQQLQEAREQGELK--EQSLQSQLDEAQRALAQRDQELEALQ 1823

Query: 1160 DMRKNL----EKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESS---LWEEASDEG 1208
              ++      E+     D ++ A+ + H  LK++  +L   +     L EE + EG
Sbjct: 1824 QEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEG 1879



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 167/765 (21%), Positives = 299/765 (39%), Gaps = 120/765 (15%)

Query: 299  KGRQGSGARPGLPEKEENEKSEPKICRN-------LVTPKADPTGSEPAKASEKEAPEDT 351
            +GR+ +  R  + E+ E  K   K  R        ++  K      +     E +  +D 
Sbjct: 1695 RGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQ 1754

Query: 352  VDAGEEGSRREEAA-----KEPKKKASALEEGSSDASQELEISEHMKEPQLSDS---IAS 403
            ++   +G  R+         + +++   L++   +A ++ E+ E   + QL ++   +A 
Sbjct: 1755 LEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQ 1814

Query: 404  DPKSFHGLDF------GFRSRISEHLLDVDVLSPVLGGACRQAQQPLG-----IED-KDD 451
              +    L        G   R+ E        +  L GA  QA   L      ++D K+ 
Sbjct: 1815 RDQELEALQQEQQQAQGQEERVKEK-------ADALQGALEQAHMTLKERHGELQDHKEQ 1867

Query: 452  SQSSQDEL--QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPE------ 503
            ++  ++EL  + ++ + LEE L   L  E R Q        ++   Q  E + E      
Sbjct: 1868 ARRLEEELAVEGRRVQALEEVLGD-LRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926

Query: 504  -WKEAEEL---GEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDP 559
             W +A+ +    +    +L  +    R Q  +  A  E  +E   +A     G+E+    
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986

Query: 560  EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQ 619
            + +++ S     +    S +      +  E AL+  E    ++ +QD R+     QE +Q
Sbjct: 1987 QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQE---GEIQDQDLRY-----QEDVQ 2038

Query: 620  QLREKLCQEEEEEILRLHQQKEQSLS-SLRERLQKAI-----------EEEEARMREEES 667
            QL++ L Q +EE  LR  Q++EQ L  SL +R+Q+ +           EEEE R   +  
Sbjct: 2039 QLQQALAQRDEE--LRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSV 2096

Query: 668  QRLSWLRAQV-QSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLK 726
            + L    AQ  Q   +  E Q R   EA     +     +Q  +  SLE + ++ LE+L+
Sbjct: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQ 2156

Query: 727  --------EEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 778
                     EIE  EK++  AL+ A+ KA     +++    + +V     E  +E +RL 
Sbjct: 2157 AALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVL----ERDSEQQRLQ 2212

Query: 779  SSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLRE 838
              LE   R    +L+K   E      A     LG    +  Q    V+G E E S    E
Sbjct: 2213 DELELTRR----ALEK---ERLHSPGATSTAELGSRGEQGVQLG-EVSGVEAEPSPDGME 2264

Query: 839  K---RQEVEGEHER----RLDKMK-EEHQQVMAKAREQYEAEERKQRAELLGHLTGELER 890
            K   RQ +E   +      +D+ + + H   +    EQ E E RK +           E 
Sbjct: 2265 KQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKR----------EA 2314

Query: 891  LQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEE 950
            ++ A    LE  +       +   R  +  + K             +++  + LL+ Q  
Sbjct: 2315 MRAAQAGSLEISKATASSPTQQDGRGQKNSDAKC----------VAELQKEVVLLQAQLT 2364

Query: 951  TARREKQQLLDVQRQVA--LKSEEATATHQQLEEAQKEHTHLLQS 993
              R++KQ  +    Q +  L     + +H  L  AQ     +L++
Sbjct: 2365 LERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEA 2409



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 135/644 (20%), Positives = 264/644 (40%), Gaps = 68/644 (10%)

Query: 600  AQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEI--------LRLHQQKEQSLSSLRERL 651
            +Q  +Q Q  L+   Q K+ Q R   CQE E+ +         R    +E +L  L  RL
Sbjct: 45   SQEAQQRQATLVRKLQAKVLQYRS-WCQELEKRLEATGGPIPQRWENVEEPNLDELLVRL 103

Query: 652  QKAIEEEEARMREEESQRLSWLRAQVQSSTQADE------DQIRAEQEASLQKLREELES 705
            ++  +  E+        RL   +A V +    ++      D  RA  E  L +   + + 
Sbjct: 104  EEEQQRCESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDE--LMRKESQWQM 161

Query: 706  QQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ---LEGERKEA 762
            +Q+  +  L+ ++ ++L   +E +  + +     + +A ++ L +L+ +   L G     
Sbjct: 162  EQEFFKGYLKGEHGRLLSLWREVV--TFRRHFLEMKSATDRDLMELKAEHVRLSGSLLTC 219

Query: 763  VATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKS 822
               L     +        ++ +    +  L  K QE +++   + Q+ + Q++ +   + 
Sbjct: 220  CLRLTVGAQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELI-QLKSQGDLEK 278

Query: 823  YHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLG 882
              +     ELS+LL + +            K  E++++++   RE  E  E     EL+ 
Sbjct: 279  AELQDRVTELSALLTQSQ------------KQNEDYEKMIKALRETVEILETNH-TELME 325

Query: 883  HLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAK-DVKAR 941
            H    L R  +  +  L+ V ++  + + +      +       LELD    ++ D +  
Sbjct: 326  H-EASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDA 384

Query: 942  LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREIL 1001
               L +      R +Q + D+++Q+A   E      QQ ++ ++E   L Q  Q+L    
Sbjct: 385  DKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGER 444

Query: 1002 DELQARKLKLESQVD-------LLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAS 1054
            D L  + + L+ +VD       LLQ   ++L++    LE EA + + +  E+ ++ ++A 
Sbjct: 445  DTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQ 504

Query: 1055 PHFE---PDLHI-----EDLRKSLGTNQTKEVSSSLSQ---SKEDLYLDSLSSHNVWHLL 1103
               E    +LH+     E L++ L   + K+ S SLS+    +E L     SSH    LL
Sbjct: 505  GQKEEQQEELHLAVRERERLQEMLMGLEAKQ-SESLSELITLREALE----SSHLEGELL 559

Query: 1104 SAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH---ELASAQE-VAKDPPGIKALE 1159
              E   + +A     Q    +   +  LK      R    +L++  E +A D  G   L 
Sbjct: 560  RQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVG---LN 616

Query: 1160 DMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEE 1203
                 LE+E + +     A  +  N L+    +  +   +LWE+
Sbjct: 617  QQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEK 660



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 143/649 (22%), Positives = 273/649 (42%), Gaps = 113/649 (17%)

Query: 673  LRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQK-------NRQMLEQL 725
            L+  ++    A + Q+   Q AS +KL+   E+QQ+  +A+L +K        R   ++L
Sbjct: 16   LQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQR--QATLVRKLQAKVLQYRSWCQEL 73

Query: 726  KEEIEASEKSEQAALNAAKEKALQQLREQLEGE--RKEAVATLEKEHSAELERLCSSLEA 783
            ++ +EA+           +E  L +L  +LE E  R E++A +  +    +E+    +  
Sbjct: 74   EKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEK-ADVVNK 132

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLRE----K 839
              RE V  L   +  ++ ++E   ++   Q+E    +   ++ G    L SL RE    +
Sbjct: 133  ALREDVEKL--TVDWSRARDELMRKESQWQMEQEFFKG--YLKGEHGRLLSLWREVVTFR 188

Query: 840  RQ--EVEGEHERRLDKMKEEHQQ-------------VMAKAREQYEA--EERKQRAELLG 882
            R   E++   +R L ++K EH +             V A++RE   +   + ++ A+LL 
Sbjct: 189  RHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLL 248

Query: 883  HLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARL 942
             L    E  + AHER  E ++ +    LE                + +L+ R  ++ A L
Sbjct: 249  LLAKTQELEKEAHERSQELIQLKSQGDLE----------------KAELQDRVTELSALL 292

Query: 943  ALLEVQEE------TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQ 996
               + Q E       A RE  ++L+      ++ E + +       AQ+E   L Q  + 
Sbjct: 293  TQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLS-----RNAQEEKLSLQQVIKD 347

Query: 997  LREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE-AEAQKKQHLLREVTVEENNASP 1055
            + +++ E      +     + L+  S      FS  +  +A K   L+R V      A  
Sbjct: 348  ITQVMVEEGDNIAQGSGHENSLELDS----SIFSQFDYQDADKALTLVRSVLTRRRQA-- 401

Query: 1056 HFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKE 1115
                   ++DLR+ L   Q  E  + L Q            H+ W     EG ALR   +
Sbjct: 402  -------VQDLRQQLAGCQ--EAVNLLQQ-----------QHDQW---EEEGKALRQRLQ 438

Query: 1116 FLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKN---LEKETRHL 1172
             L  +  ++  +   L+         L+  +E+ +     KA E++R+    LE+E   L
Sbjct: 439  KLTGERDTLAGQTVDLQGEVD----SLSKERELLQ-----KAREELRQQLEVLEQEAWRL 489

Query: 1173 DEMKSAMR-KGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS 1231
              +   ++ +G +   +KEE+  +L  ++ E    +  L G   K++ +  LS++ +L  
Sbjct: 490  RRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSES--LSELITL-R 546

Query: 1232 ESSESFSPPHREWWRQQRIDSTPSL--TSRKIHGLSHSLRQISSQLSSV 1278
            E+ ES S    E  RQ++ + T +L    + I  LS S   + ++++ +
Sbjct: 547  EALES-SHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADL 594


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score =  127 bits (319), Expect = 8e-29
 Identities = 159/755 (21%), Positives = 334/755 (44%), Gaps = 79/755 (10%)

Query: 570  PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH--LLESKQEKMQQLREK--L 625
            P+    R  E +   E   +   +  ++A  ++ E +Q+H  L E K    +QL+ +  L
Sbjct: 843  PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 626  CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADE 685
              E EE  +RL   K+Q L  +   ++  +EEEE R ++ +++R    +  +    Q +E
Sbjct: 903  YAEAEEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 686  DQIRAEQEASLQKLREELESQQKAERASL--EQKNRQMLEQLKEEIEASEKSEQAALNAA 743
            ++  A Q+  L+K+  E + ++  +   +  +Q N+   E+   E   S+ +   A    
Sbjct: 962  EEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 744  KEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLE---AKHREVVSSLQKKIQE 798
            K K L +L+ + E    E    L+KE  +  ELE+L   LE   +   E ++ LQ +I E
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 799  AQQ---KEEAQLQKCLGQVEHRVHQKSY----------HVAGYEHELSS--LLREKRQEV 843
             +    K+E +LQ  L +++  + QK+           H++  + +L S    R K ++ 
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
            + +    L+ +K E +  +     Q E   R +R + +  L   L+   R+HE +++ +R
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DVKARLALLEVQEETARREKQQLL 960
            Q+  + +E+L  +  + +R   +L+ + +T  K   D+   L +L   ++    +K++L 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL- 1257

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
                              Q++E Q + +   ++  +L + + +LQ     +   ++  + 
Sbjct: 1258 ----------------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080
            ++ +L K  +SL ++ Q  Q LL+E T ++ N S        +E+ R SL     +E+  
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR---QLEEERNSLQDQLDEEME- 1357

Query: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140
                          +  N+   +S   + L  +K+ L     ++     AL+  ++ ++ 
Sbjct: 1358 --------------AKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKKRFQK 1399

Query: 1141 ELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL--- 1196
            E+ +  Q+  +       LE  +  L++E   L       R+  + L+KK+ K +QL   
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1197 ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS--ESSESFSPPHREWWRQ-QRIDST 1253
            E ++  + +DE     +  ++  T  LS   +L    E+ E     ++    + + + S+
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 1254 PSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
                 + +H L  S R + +Q+  + + L+ L  +
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554



 Score =  108 bits (269), Expect = 5e-23
 Identities = 194/996 (19%), Positives = 412/996 (41%), Gaps = 178/996 (17%)

Query: 331  KADPTGSEPAKASEKEAPEDTVDAGEEGSRR-EEAAKEPKKKASALEEGSSDASQELEIS 389
            K  P      +  E +A ED +   +E  ++ E   KE ++K S L E  +   ++L+  
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899

Query: 390  EHM--KEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
              +  +  ++   +A+  +    +     +R+ E   + D    +     + AQQ L +E
Sbjct: 900  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 956

Query: 448  DK-DDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
            ++ ++ ++++ +LQ                  E+  +  +    E+E     +   +  +
Sbjct: 957  EQLEEEEAARQKLQL-----------------EKVTAEAKIKKLEDEILVMDDQNNKLSK 999

Query: 507  AEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS 566
              +L E+  + L+  L+ + E+A +      K +   S+ E     +E++    EK+   
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK-- 1057

Query: 567  PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLC 626
                     R  E  A       A L+A    +A++  Q     L  K+E++Q    +L 
Sbjct: 1058 ---------RKLEGDASDFHEQIADLQAQ---IAELKMQ-----LAKKEEELQAALARLD 1100

Query: 627  QE--EEEEILRLHQQKEQSLSSLRERL--QKAIEEEEARMREEESQRLSWLRAQVQSS-- 680
             E  ++   L+  ++ E  +S L+E L  ++A   +  + + +  + L  L+ +++ +  
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 681  TQADEDQIRAEQEASLQKLREELESQQKAERASLE---QKNRQMLEQLKEEIEASEKSE- 736
            + A + ++RA++E  +  L++ L+ + ++  A ++   QK+ Q +E+L E++E  ++++ 
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 737  -----------QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
                       + A  A + + L Q ++++E ++K+  A ++     EL+  CS  E   
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERAR 1275

Query: 786  REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 845
             E    L  K+ + Q + E+ +   L + E +  + +  VA     LSS L++ ++ ++ 
Sbjct: 1276 AE----LNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQE 1326

Query: 846  EHERRLD------KMKEEHQQVMAKAREQYEAEER---------------KQRAELLGHL 884
            E  ++L+      +++EE   +  +  E+ EA++                K++ +     
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 885  TGELERLQRAHERELETVRQEQHKRL---EDLRRRHREQERKLQDLELDL---------- 931
               LE  ++  ++E+E + Q+  ++    + L +     +++L DL +DL          
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 932  ------------------------------ETRAKDVKARLAL-------LEVQEETARR 954
                                          E R K+ KA L+L       LE +EE  R 
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEALEAKEELERT 1505

Query: 955  EKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR---KLKL 1011
             K    +++  V+ K +     H+  +  +   T + +   QL E+ DELQA    KL+L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1012 ESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENN----------ASPHFEPD 1060
            E  +  L+ Q ++ LQ      E + ++ Q  L E   E  +          A    E D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 1061 LHIEDLR-------KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSA 1113
            L   +L+       +     Q +++ + +   + +L     S   ++          +S 
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685

Query: 1114 KEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKE----T 1169
            +  L+Q    +   + A K A    + ELA  +E+A    G  AL+D ++ LE       
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLE-KEELA--EELASSLSGRNALQDEKRRLEARIAQLE 1742

Query: 1170 RHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEAS 1205
              L+E +  M    + ++K  ++  QL + L  E S
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778



 Score =  103 bits (257), Expect = 1e-21
 Identities = 169/800 (21%), Positives = 336/800 (42%), Gaps = 112/800 (14%)

Query: 446  IEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK 505
            +ED  DS ++Q EL++K+ + +   L   L  E R+         + +  +    Q   +
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTV-LKKALDEETRSHE------AQVQEMRQKHAQAVEE 1207

Query: 506  EAEELGEDSAASLSLQLSLQREQAPSPPAACE-------------KGKEQHSQAEEL--- 549
              E+L +   A  +L  + Q  +  +   A E             K K+  +Q +EL   
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267

Query: 550  -GPGQEEAEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQD 606
               G+    +  +KV    +    V+  +   E  A       A+L +  +   ++L+++
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327

Query: 607  QRHLLESKQEKMQQLREKL--CQEEEEEILRLHQQKEQSLSSL-------RERLQ----- 652
             R  L +   K++QL E+    Q++ +E +   Q  E+ +S+L       +++LQ     
Sbjct: 1328 TRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 653  -KAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             +A+EE + R ++E          +  +  + ++ + R +QE  L  L  +L++Q++   
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDNQRQLV- 1443

Query: 712  ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK--E 769
            ++LE+K R+  + L EE   S K         +++A  + RE+ E +       LE+  E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADE-----RDRAEAEAREK-ETKALSLARALEEALE 1497

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               ELER    L+A+  ++VSS     ++   K   +L+K    +E ++ +    +   E
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSS-----KDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 830  HELSSL------LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQR 877
             EL +       L    Q ++G+ ER L   D+  EE ++ + +   +YE E   ERKQR
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 878  AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            A     L    ++      ++LE       K  E+  ++ R+ + +++D + +LE     
Sbjct: 1613 A-----LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 997
                 A  +  E+ A+  +  L+ +Q  +A           + EE  +E    L     L
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727

Query: 998  REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            ++    L+AR  +LE +   L+ +   ++     +    Q+ + L  E+  E + A  + 
Sbjct: 1728 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN- 1783

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
                  E  R+ L   Q KE+ S L +      ++          ++A    +   +E +
Sbjct: 1784 ------ESARQQL-ERQNKELRSKLHE------MEGAVKSKFKSTIAALEAKIAQLEEQV 1830

Query: 1118 VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
             Q+    R +Q A K+ +Q             KD    K L+++   +E E +  ++ K 
Sbjct: 1831 EQEA---REKQAATKSLKQ-------------KD----KKLKEILLQVEDERKMAEQYKE 1870

Query: 1178 AMRKGHNLLKKKEEKLNQLE 1197
               KG+  +K+ + +L + E
Sbjct: 1871 QAEKGNARVKQLKRQLEEAE 1890



 Score =  102 bits (254), Expect = 3e-21
 Identities = 192/889 (21%), Positives = 355/889 (39%), Gaps = 167/889 (18%)

Query: 232  HSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADS 291
            +++ + +R L   I  L  D + E + R    ++K+D+  + +A                
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------------- 1150

Query: 292  SLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDT 351
             L + +      +  +  L  K E E +        V  KA    +   +A  +E  +  
Sbjct: 1151 -LKTELEDTLDSTATQQELRAKREQEVT--------VLKKALDEETRSHEAQVQEMRQKH 1201

Query: 352  VDAGEEGSRREEAAKEPK----KKASALEEGSSDASQELEIS-------EHMKEPQLSDS 400
              A EE + + E  K  K    K    LE+ ++D + EL +        EH K+   +  
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 401  IASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ 460
                 K   G           H L  +V S  + G   +A+    I+   D  S   +LQ
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVES--VTGMLNEAEGK-AIKLAKDVASLSSQLQ 1318

Query: 461  SKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSL 520
              Q    EE         ++     +    EEE     +   E  EA++  E   ++L++
Sbjct: 1319 DTQELLQEET-------RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 521  QLSLQREQAP---SPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRS 577
            QLS  +++     S   A E+GK++          Q+E E+  ++               
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRF---------QKEIENLTQQYE------------- 1409

Query: 578  TEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLH 637
             E  A  ++L +   +  +E    V++ D +  L S  EK Q+  ++L  EE+    +  
Sbjct: 1410 -EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 638  QQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS------------- 679
             +++++ +  RE+  KA+      EE    +EE  +    L+A+++              
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 680  ----------------STQADE--DQIRAEQEASL------QKLREELESQQKAERASLE 715
                             TQ +E  D+++A ++A L      Q L+ + E   +A     E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 716  QKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAVATLE 767
            +K RQ+  QL E E E  ++ +Q AL AA +K L+   + LE +       R+EA+  L 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 768  KEHSA--ELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSY 823
            K  +   + +R      A   E+ ++ ++  ++A+  E    QLQ+ L   E    Q   
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708

Query: 824  HVAGYEHELSSLL--REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
                   EL+S L  R   Q+ +   E R+ +++EE ++      EQ   E    R    
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR-- 1760

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD---- 937
               T + E+L      E  T ++ +  R + L R+++E   KL ++E  ++++ K     
Sbjct: 1761 -KATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 938  VKARLALLEVQEETARREKQ------------------QLLDVQRQVALKSEEATATH-- 977
            ++A++A LE Q E   REKQ                  Q+ D ++      E+A   +  
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878

Query: 978  -----QQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
                 +QLEEA++E   +  + ++L+  LDE       +  +V+ L+++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score =  127 bits (319), Expect = 8e-29
 Identities = 159/755 (21%), Positives = 334/755 (44%), Gaps = 79/755 (10%)

Query: 570  PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH--LLESKQEKMQQLREK--L 625
            P+    R  E +   E   +   +  ++A  ++ E +Q+H  L E K    +QL+ +  L
Sbjct: 850  PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 626  CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADE 685
              E EE  +RL   K+Q L  +   ++  +EEEE R ++ +++R    +  +    Q +E
Sbjct: 910  YAEAEEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 686  DQIRAEQEASLQKLREELESQQKAERASL--EQKNRQMLEQLKEEIEASEKSEQAALNAA 743
            ++  A Q+  L+K+  E + ++  +   +  +Q N+   E+   E   S+ +   A    
Sbjct: 969  EEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 744  KEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLE---AKHREVVSSLQKKIQE 798
            K K L +L+ + E    E    L+KE  +  ELE+L   LE   +   E ++ LQ +I E
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 799  AQQ---KEEAQLQKCLGQVEHRVHQKSY----------HVAGYEHELSS--LLREKRQEV 843
             +    K+E +LQ  L +++  + QK+           H++  + +L S    R K ++ 
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
            + +    L+ +K E +  +     Q E   R +R + +  L   L+   R+HE +++ +R
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DVKARLALLEVQEETARREKQQLL 960
            Q+  + +E+L  +  + +R   +L+ + +T  K   D+   L +L   ++    +K++L 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL- 1264

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
                              Q++E Q + +   ++  +L + + +LQ     +   ++  + 
Sbjct: 1265 ----------------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080
            ++ +L K  +SL ++ Q  Q LL+E T ++ N S        +E+ R SL     +E+  
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR---QLEEERNSLQDQLDEEME- 1364

Query: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140
                          +  N+   +S   + L  +K+ L     ++     AL+  ++ ++ 
Sbjct: 1365 --------------AKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKKRFQK 1406

Query: 1141 ELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL--- 1196
            E+ +  Q+  +       LE  +  L++E   L       R+  + L+KK+ K +QL   
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1197 ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS--ESSESFSPPHREWWRQ-QRIDST 1253
            E ++  + +DE     +  ++  T  LS   +L    E+ E     ++    + + + S+
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 1254 PSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
                 + +H L  S R + +Q+  + + L+ L  +
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561



 Score =  108 bits (269), Expect = 5e-23
 Identities = 194/996 (19%), Positives = 412/996 (41%), Gaps = 178/996 (17%)

Query: 331  KADPTGSEPAKASEKEAPEDTVDAGEEGSRR-EEAAKEPKKKASALEEGSSDASQELEIS 389
            K  P      +  E +A ED +   +E  ++ E   KE ++K S L E  +   ++L+  
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 390  EHM--KEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
              +  +  ++   +A+  +    +     +R+ E   + D    +     + AQQ L +E
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 963

Query: 448  DK-DDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
            ++ ++ ++++ +LQ                  E+  +  +    E+E     +   +  +
Sbjct: 964  EQLEEEEAARQKLQL-----------------EKVTAEAKIKKLEDEILVMDDQNNKLSK 1006

Query: 507  AEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS 566
              +L E+  + L+  L+ + E+A +      K +   S+ E     +E++    EK+   
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK-- 1064

Query: 567  PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLC 626
                     R  E  A       A L+A    +A++  Q     L  K+E++Q    +L 
Sbjct: 1065 ---------RKLEGDASDFHEQIADLQAQ---IAELKMQ-----LAKKEEELQAALARLD 1107

Query: 627  QE--EEEEILRLHQQKEQSLSSLRERL--QKAIEEEEARMREEESQRLSWLRAQVQSS-- 680
             E  ++   L+  ++ E  +S L+E L  ++A   +  + + +  + L  L+ +++ +  
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 681  TQADEDQIRAEQEASLQKLREELESQQKAERASLE---QKNRQMLEQLKEEIEASEKSE- 736
            + A + ++RA++E  +  L++ L+ + ++  A ++   QK+ Q +E+L E++E  ++++ 
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 737  -----------QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
                       + A  A + + L Q ++++E ++K+  A ++     EL+  CS  E   
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERAR 1282

Query: 786  REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 845
             E    L  K+ + Q + E+ +   L + E +  + +  VA     LSS L++ ++ ++ 
Sbjct: 1283 AE----LNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQE 1333

Query: 846  EHERRLD------KMKEEHQQVMAKAREQYEAEER---------------KQRAELLGHL 884
            E  ++L+      +++EE   +  +  E+ EA++                K++ +     
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 885  TGELERLQRAHERELETVRQEQHKRL---EDLRRRHREQERKLQDLELDL---------- 931
               LE  ++  ++E+E + Q+  ++    + L +     +++L DL +DL          
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 932  ------------------------------ETRAKDVKARLAL-------LEVQEETARR 954
                                          E R K+ KA L+L       LE +EE  R 
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEALEAKEELERT 1512

Query: 955  EKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR---KLKL 1011
             K    +++  V+ K +     H+  +  +   T + +   QL E+ DELQA    KL+L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1012 ESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENN----------ASPHFEPD 1060
            E  +  L+ Q ++ LQ      E + ++ Q  L E   E  +          A    E D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 1061 LHIEDLR-------KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSA 1113
            L   +L+       +     Q +++ + +   + +L     S   ++          +S 
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692

Query: 1114 KEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKE----T 1169
            +  L+Q    +   + A K A    + ELA  +E+A    G  AL+D ++ LE       
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLE-KEELA--EELASSLSGRNALQDEKRRLEARIAQLE 1749

Query: 1170 RHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEAS 1205
              L+E +  M    + ++K  ++  QL + L  E S
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785



 Score =  103 bits (257), Expect = 1e-21
 Identities = 169/800 (21%), Positives = 336/800 (42%), Gaps = 112/800 (14%)

Query: 446  IEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK 505
            +ED  DS ++Q EL++K+ + +   L   L  E R+         + +  +    Q   +
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTV-LKKALDEETRSHE------AQVQEMRQKHAQAVEE 1214

Query: 506  EAEELGEDSAASLSLQLSLQREQAPSPPAACE-------------KGKEQHSQAEEL--- 549
              E+L +   A  +L  + Q  +  +   A E             K K+  +Q +EL   
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274

Query: 550  -GPGQEEAEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQD 606
               G+    +  +KV    +    V+  +   E  A       A+L +  +   ++L+++
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 607  QRHLLESKQEKMQQLREKL--CQEEEEEILRLHQQKEQSLSSL-------RERLQ----- 652
             R  L +   K++QL E+    Q++ +E +   Q  E+ +S+L       +++LQ     
Sbjct: 1335 TRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 653  -KAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             +A+EE + R ++E          +  +  + ++ + R +QE  L  L  +L++Q++   
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDNQRQLV- 1450

Query: 712  ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK--E 769
            ++LE+K R+  + L EE   S K         +++A  + RE+ E +       LE+  E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADE-----RDRAEAEAREK-ETKALSLARALEEALE 1504

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               ELER    L+A+  ++VSS     ++   K   +L+K    +E ++ +    +   E
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSS-----KDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 830  HELSSL------LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQR 877
             EL +       L    Q ++G+ ER L   D+  EE ++ + +   +YE E   ERKQR
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 878  AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            A     L    ++      ++LE       K  E+  ++ R+ + +++D + +LE     
Sbjct: 1620 A-----LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 997
                 A  +  E+ A+  +  L+ +Q  +A           + EE  +E    L     L
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734

Query: 998  REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            ++    L+AR  +LE +   L+ +   ++     +    Q+ + L  E+  E + A  + 
Sbjct: 1735 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN- 1790

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
                  E  R+ L   Q KE+ S L +      ++          ++A    +   +E +
Sbjct: 1791 ------ESARQQL-ERQNKELRSKLHE------MEGAVKSKFKSTIAALEAKIAQLEEQV 1837

Query: 1118 VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
             Q+    R +Q A K+ +Q             KD    K L+++   +E E +  ++ K 
Sbjct: 1838 EQEA---REKQAATKSLKQ-------------KD----KKLKEILLQVEDERKMAEQYKE 1877

Query: 1178 AMRKGHNLLKKKEEKLNQLE 1197
               KG+  +K+ + +L + E
Sbjct: 1878 QAEKGNARVKQLKRQLEEAE 1897



 Score =  102 bits (254), Expect = 3e-21
 Identities = 192/889 (21%), Positives = 355/889 (39%), Gaps = 167/889 (18%)

Query: 232  HSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADS 291
            +++ + +R L   I  L  D + E + R    ++K+D+  + +A                
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------------- 1157

Query: 292  SLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDT 351
             L + +      +  +  L  K E E +        V  KA    +   +A  +E  +  
Sbjct: 1158 -LKTELEDTLDSTATQQELRAKREQEVT--------VLKKALDEETRSHEAQVQEMRQKH 1208

Query: 352  VDAGEEGSRREEAAKEPK----KKASALEEGSSDASQELEIS-------EHMKEPQLSDS 400
              A EE + + E  K  K    K    LE+ ++D + EL +        EH K+   +  
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 401  IASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ 460
                 K   G           H L  +V S  + G   +A+    I+   D  S   +LQ
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVES--VTGMLNEAEGK-AIKLAKDVASLSSQLQ 1325

Query: 461  SKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSL 520
              Q    EE         ++     +    EEE     +   E  EA++  E   ++L++
Sbjct: 1326 DTQELLQEET-------RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 521  QLSLQREQAP---SPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRS 577
            QLS  +++     S   A E+GK++          Q+E E+  ++               
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRF---------QKEIENLTQQYE------------- 1416

Query: 578  TEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLH 637
             E  A  ++L +   +  +E    V++ D +  L S  EK Q+  ++L  EE+    +  
Sbjct: 1417 -EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 638  QQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS------------- 679
             +++++ +  RE+  KA+      EE    +EE  +    L+A+++              
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 680  ----------------STQADE--DQIRAEQEASL------QKLREELESQQKAERASLE 715
                             TQ +E  D+++A ++A L      Q L+ + E   +A     E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 716  QKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAVATLE 767
            +K RQ+  QL E E E  ++ +Q AL AA +K L+   + LE +       R+EA+  L 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 768  KEHSA--ELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSY 823
            K  +   + +R      A   E+ ++ ++  ++A+  E    QLQ+ L   E    Q   
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715

Query: 824  HVAGYEHELSSLL--REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
                   EL+S L  R   Q+ +   E R+ +++EE ++      EQ   E    R    
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR-- 1767

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD---- 937
               T + E+L      E  T ++ +  R + L R+++E   KL ++E  ++++ K     
Sbjct: 1768 -KATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 938  VKARLALLEVQEETARREKQ------------------QLLDVQRQVALKSEEATATH-- 977
            ++A++A LE Q E   REKQ                  Q+ D ++      E+A   +  
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885

Query: 978  -----QQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
                 +QLEEA++E   +  + ++L+  LDE       +  +V+ L+++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score =  127 bits (319), Expect = 8e-29
 Identities = 159/755 (21%), Positives = 334/755 (44%), Gaps = 79/755 (10%)

Query: 570  PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH--LLESKQEKMQQLREK--L 625
            P+    R  E +   E   +   +  ++A  ++ E +Q+H  L E K    +QL+ +  L
Sbjct: 850  PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 909

Query: 626  CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADE 685
              E EE  +RL   K+Q L  +   ++  +EEEE R ++ +++R    +  +    Q +E
Sbjct: 910  YAEAEEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 968

Query: 686  DQIRAEQEASLQKLREELESQQKAERASL--EQKNRQMLEQLKEEIEASEKSEQAALNAA 743
            ++  A Q+  L+K+  E + ++  +   +  +Q N+   E+   E   S+ +   A    
Sbjct: 969  EEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 744  KEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLE---AKHREVVSSLQKKIQE 798
            K K L +L+ + E    E    L+KE  +  ELE+L   LE   +   E ++ LQ +I E
Sbjct: 1028 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1087

Query: 799  AQQ---KEEAQLQKCLGQVEHRVHQKSY----------HVAGYEHELSS--LLREKRQEV 843
             +    K+E +LQ  L +++  + QK+           H++  + +L S    R K ++ 
Sbjct: 1088 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1147

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
            + +    L+ +K E +  +     Q E   R +R + +  L   L+   R+HE +++ +R
Sbjct: 1148 KRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKKALDEETRSHEAQVQEMR 1205

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DVKARLALLEVQEETARREKQQLL 960
            Q+  + +E+L  +  + +R   +L+ + +T  K   D+   L +L   ++    +K++L 
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL- 1264

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
                              Q++E Q + +   ++  +L + + +LQ     +   ++  + 
Sbjct: 1265 ----------------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1308

Query: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080
            ++ +L K  +SL ++ Q  Q LL+E T ++ N S        +E+ R SL     +E+  
Sbjct: 1309 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR---QLEEERNSLQDQLDEEME- 1364

Query: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140
                          +  N+   +S   + L  +K+ L     ++     AL+  ++ ++ 
Sbjct: 1365 --------------AKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKKRFQK 1406

Query: 1141 ELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL--- 1196
            E+ +  Q+  +       LE  +  L++E   L       R+  + L+KK+ K +QL   
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1466

Query: 1197 ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS--ESSESFSPPHREWWRQ-QRIDST 1253
            E ++  + +DE     +  ++  T  LS   +L    E+ E     ++    + + + S+
Sbjct: 1467 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1526

Query: 1254 PSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
                 + +H L  S R + +Q+  + + L+ L  +
Sbjct: 1527 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561



 Score =  108 bits (269), Expect = 5e-23
 Identities = 194/996 (19%), Positives = 412/996 (41%), Gaps = 178/996 (17%)

Query: 331  KADPTGSEPAKASEKEAPEDTVDAGEEGSRR-EEAAKEPKKKASALEEGSSDASQELEIS 389
            K  P      +  E +A ED +   +E  ++ E   KE ++K S L E  +   ++L+  
Sbjct: 847  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 906

Query: 390  EHM--KEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
              +  +  ++   +A+  +    +     +R+ E   + D    +     + AQQ L +E
Sbjct: 907  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 963

Query: 448  DK-DDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
            ++ ++ ++++ +LQ                  E+  +  +    E+E     +   +  +
Sbjct: 964  EQLEEEEAARQKLQL-----------------EKVTAEAKIKKLEDEILVMDDQNNKLSK 1006

Query: 507  AEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS 566
              +L E+  + L+  L+ + E+A +      K +   S+ E     +E++    EK+   
Sbjct: 1007 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK-- 1064

Query: 567  PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLC 626
                     R  E  A       A L+A    +A++  Q     L  K+E++Q    +L 
Sbjct: 1065 ---------RKLEGDASDFHEQIADLQAQ---IAELKMQ-----LAKKEEELQAALARLD 1107

Query: 627  QE--EEEEILRLHQQKEQSLSSLRERL--QKAIEEEEARMREEESQRLSWLRAQVQSS-- 680
             E  ++   L+  ++ E  +S L+E L  ++A   +  + + +  + L  L+ +++ +  
Sbjct: 1108 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1167

Query: 681  TQADEDQIRAEQEASLQKLREELESQQKAERASLE---QKNRQMLEQLKEEIEASEKSE- 736
            + A + ++RA++E  +  L++ L+ + ++  A ++   QK+ Q +E+L E++E  ++++ 
Sbjct: 1168 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1227

Query: 737  -----------QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
                       + A  A + + L Q ++++E ++K+  A ++     EL+  CS  E   
Sbjct: 1228 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERAR 1282

Query: 786  REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 845
             E    L  K+ + Q + E+ +   L + E +  + +  VA     LSS L++ ++ ++ 
Sbjct: 1283 AE----LNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQE 1333

Query: 846  EHERRLD------KMKEEHQQVMAKAREQYEAEER---------------KQRAELLGHL 884
            E  ++L+      +++EE   +  +  E+ EA++                K++ +     
Sbjct: 1334 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 885  TGELERLQRAHERELETVRQEQHKRL---EDLRRRHREQERKLQDLELDL---------- 931
               LE  ++  ++E+E + Q+  ++    + L +     +++L DL +DL          
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1453

Query: 932  ------------------------------ETRAKDVKARLAL-------LEVQEETARR 954
                                          E R K+ KA L+L       LE +EE  R 
Sbjct: 1454 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEALEAKEELERT 1512

Query: 955  EKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR---KLKL 1011
             K    +++  V+ K +     H+  +  +   T + +   QL E+ DELQA    KL+L
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572

Query: 1012 ESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENN----------ASPHFEPD 1060
            E  +  L+ Q ++ LQ      E + ++ Q  L E   E  +          A    E D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632

Query: 1061 LHIEDLR-------KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSA 1113
            L   +L+       +     Q +++ + +   + +L     S   ++          +S 
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1692

Query: 1114 KEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKE----T 1169
            +  L+Q    +   + A K A    + ELA  +E+A    G  AL+D ++ LE       
Sbjct: 1693 EADLMQLQEDLAAAERARKQADLE-KEELA--EELASSLSGRNALQDEKRRLEARIAQLE 1749

Query: 1170 RHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEAS 1205
              L+E +  M    + ++K  ++  QL + L  E S
Sbjct: 1750 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785



 Score =  103 bits (257), Expect = 1e-21
 Identities = 169/800 (21%), Positives = 336/800 (42%), Gaps = 112/800 (14%)

Query: 446  IEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK 505
            +ED  DS ++Q EL++K+ + +   L   L  E R+         + +  +    Q   +
Sbjct: 1162 LEDTLDSTATQQELRAKREQEVTV-LKKALDEETRSHE------AQVQEMRQKHAQAVEE 1214

Query: 506  EAEELGEDSAASLSLQLSLQREQAPSPPAACE-------------KGKEQHSQAEEL--- 549
              E+L +   A  +L  + Q  +  +   A E             K K+  +Q +EL   
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274

Query: 550  -GPGQEEAEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQD 606
               G+    +  +KV    +    V+  +   E  A       A+L +  +   ++L+++
Sbjct: 1275 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1334

Query: 607  QRHLLESKQEKMQQLREKL--CQEEEEEILRLHQQKEQSLSSL-------RERLQ----- 652
             R  L +   K++QL E+    Q++ +E +   Q  E+ +S+L       +++LQ     
Sbjct: 1335 TRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1393

Query: 653  -KAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             +A+EE + R ++E          +  +  + ++ + R +QE  L  L  +L++Q++   
Sbjct: 1394 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDNQRQLV- 1450

Query: 712  ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK--E 769
            ++LE+K R+  + L EE   S K         +++A  + RE+ E +       LE+  E
Sbjct: 1451 SNLEKKQRKFDQLLAEEKNISSKYADE-----RDRAEAEAREK-ETKALSLARALEEALE 1504

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               ELER    L+A+  ++VSS     ++   K   +L+K    +E ++ +    +   E
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSS-----KDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1559

Query: 830  HELSSL------LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQR 877
             EL +       L    Q ++G+ ER L   D+  EE ++ + +   +YE E   ERKQR
Sbjct: 1560 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1619

Query: 878  AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            A     L    ++      ++LE       K  E+  ++ R+ + +++D + +LE     
Sbjct: 1620 A-----LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1674

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 997
                 A  +  E+ A+  +  L+ +Q  +A           + EE  +E    L     L
Sbjct: 1675 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1734

Query: 998  REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            ++    L+AR  +LE +   L+ +   ++     +    Q+ + L  E+  E + A  + 
Sbjct: 1735 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN- 1790

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
                  E  R+ L   Q KE+ S L +      ++          ++A    +   +E +
Sbjct: 1791 ------ESARQQL-ERQNKELRSKLHE------MEGAVKSKFKSTIAALEAKIAQLEEQV 1837

Query: 1118 VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
             Q+    R +Q A K+ +Q             KD    K L+++   +E E +  ++ K 
Sbjct: 1838 EQEA---REKQAATKSLKQ-------------KD----KKLKEILLQVEDERKMAEQYKE 1877

Query: 1178 AMRKGHNLLKKKEEKLNQLE 1197
               KG+  +K+ + +L + E
Sbjct: 1878 QAEKGNARVKQLKRQLEEAE 1897



 Score =  102 bits (254), Expect = 3e-21
 Identities = 192/889 (21%), Positives = 355/889 (39%), Gaps = 167/889 (18%)

Query: 232  HSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADS 291
            +++ + +R L   I  L  D + E + R    ++K+D+  + +A                
Sbjct: 1114 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------------- 1157

Query: 292  SLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDT 351
             L + +      +  +  L  K E E +        V  KA    +   +A  +E  +  
Sbjct: 1158 -LKTELEDTLDSTATQQELRAKREQEVT--------VLKKALDEETRSHEAQVQEMRQKH 1208

Query: 352  VDAGEEGSRREEAAKEPK----KKASALEEGSSDASQELEIS-------EHMKEPQLSDS 400
              A EE + + E  K  K    K    LE+ ++D + EL +        EH K+   +  
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 401  IASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ 460
                 K   G           H L  +V S  + G   +A+    I+   D  S   +LQ
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVES--VTGMLNEAEGK-AIKLAKDVASLSSQLQ 1325

Query: 461  SKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSL 520
              Q    EE         ++     +    EEE     +   E  EA++  E   ++L++
Sbjct: 1326 DTQELLQEET-------RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1378

Query: 521  QLSLQREQAP---SPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRS 577
            QLS  +++     S   A E+GK++          Q+E E+  ++               
Sbjct: 1379 QLSDSKKKLQDFASTVEALEEGKKRF---------QKEIENLTQQYE------------- 1416

Query: 578  TEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLH 637
             E  A  ++L +   +  +E    V++ D +  L S  EK Q+  ++L  EE+    +  
Sbjct: 1417 -EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1475

Query: 638  QQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS------------- 679
             +++++ +  RE+  KA+      EE    +EE  +    L+A+++              
Sbjct: 1476 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1535

Query: 680  ----------------STQADE--DQIRAEQEASL------QKLREELESQQKAERASLE 715
                             TQ +E  D+++A ++A L      Q L+ + E   +A     E
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595

Query: 716  QKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAVATLE 767
            +K RQ+  QL E E E  ++ +Q AL AA +K L+   + LE +       R+EA+  L 
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655

Query: 768  KEHSA--ELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSY 823
            K  +   + +R      A   E+ ++ ++  ++A+  E    QLQ+ L   E    Q   
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715

Query: 824  HVAGYEHELSSLL--REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
                   EL+S L  R   Q+ +   E R+ +++EE ++      EQ   E    R    
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR-- 1767

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD---- 937
               T + E+L      E  T ++ +  R + L R+++E   KL ++E  ++++ K     
Sbjct: 1768 -KATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1825

Query: 938  VKARLALLEVQEETARREKQ------------------QLLDVQRQVALKSEEATATH-- 977
            ++A++A LE Q E   REKQ                  Q+ D ++      E+A   +  
Sbjct: 1826 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1885

Query: 978  -----QQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
                 +QLEEA++E   +  + ++L+  LDE       +  +V+ L+++
Sbjct: 1886 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score =  127 bits (319), Expect = 8e-29
 Identities = 159/755 (21%), Positives = 334/755 (44%), Gaps = 79/755 (10%)

Query: 570  PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH--LLESKQEKMQQLREK--L 625
            P+    R  E +   E   +   +  ++A  ++ E +Q+H  L E K    +QL+ +  L
Sbjct: 843  PLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETEL 902

Query: 626  CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADE 685
              E EE  +RL   K+Q L  +   ++  +EEEE R ++ +++R    +  +    Q +E
Sbjct: 903  YAEAEEMRVRL-AAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEE 961

Query: 686  DQIRAEQEASLQKLREELESQQKAERASL--EQKNRQMLEQLKEEIEASEKSEQAALNAA 743
            ++  A Q+  L+K+  E + ++  +   +  +Q N+   E+   E   S+ +   A    
Sbjct: 962  EEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 744  KEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLE---AKHREVVSSLQKKIQE 798
            K K L +L+ + E    E    L+KE  +  ELE+L   LE   +   E ++ LQ +I E
Sbjct: 1021 KAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAE 1080

Query: 799  AQQ---KEEAQLQKCLGQVEHRVHQKSY----------HVAGYEHELSS--LLREKRQEV 843
             +    K+E +LQ  L +++  + QK+           H++  + +L S    R K ++ 
Sbjct: 1081 LKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQ 1140

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
            + +    L+ +K E +  +     Q E   R +R + +  L   L+   R+HE +++ +R
Sbjct: 1141 KRDLGEELEALKTELEDTLDSTATQQEL--RAKREQEVTVLKKALDEETRSHEAQVQEMR 1198

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAK---DVKARLALLEVQEETARREKQQLL 960
            Q+  + +E+L  +  + +R   +L+ + +T  K   D+   L +L   ++    +K++L 
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL- 1257

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
                              Q++E Q + +   ++  +L + + +LQ     +   ++  + 
Sbjct: 1258 ----------------EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEG 1301

Query: 1021 QSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSS 1080
            ++ +L K  +SL ++ Q  Q LL+E T ++ N S        +E+ R SL     +E+  
Sbjct: 1302 KAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR---QLEEERNSLQDQLDEEME- 1357

Query: 1081 SLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRH 1140
                          +  N+   +S   + L  +K+ L     ++     AL+  ++ ++ 
Sbjct: 1358 --------------AKQNLERHISTLNIQLSDSKKKLQDFASTVE----ALEEGKKRFQK 1399

Query: 1141 ELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL--- 1196
            E+ +  Q+  +       LE  +  L++E   L       R+  + L+KK+ K +QL   
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAE 1459

Query: 1197 ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS--ESSESFSPPHREWWRQ-QRIDST 1253
            E ++  + +DE     +  ++  T  LS   +L    E+ E     ++    + + + S+
Sbjct: 1460 EKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSS 1519

Query: 1254 PSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
                 + +H L  S R + +Q+  + + L+ L  +
Sbjct: 1520 KDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554



 Score =  108 bits (269), Expect = 5e-23
 Identities = 194/996 (19%), Positives = 412/996 (41%), Gaps = 178/996 (17%)

Query: 331  KADPTGSEPAKASEKEAPEDTVDAGEEGSRR-EEAAKEPKKKASALEEGSSDASQELEIS 389
            K  P      +  E +A ED +   +E  ++ E   KE ++K S L E  +   ++L+  
Sbjct: 840  KVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAE 899

Query: 390  EHM--KEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE 447
              +  +  ++   +A+  +    +     +R+ E   + D    +     + AQQ L +E
Sbjct: 900  TELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKKMAQQMLDLE 956

Query: 448  DK-DDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKE 506
            ++ ++ ++++ +LQ                  E+  +  +    E+E     +   +  +
Sbjct: 957  EQLEEEEAARQKLQL-----------------EKVTAEAKIKKLEDEILVMDDQNNKLSK 999

Query: 507  AEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVS 566
              +L E+  + L+  L+ + E+A +      K +   S+ E     +E++    EK+   
Sbjct: 1000 ERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLK-- 1057

Query: 567  PTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLC 626
                     R  E  A       A L+A    +A++  Q     L  K+E++Q    +L 
Sbjct: 1058 ---------RKLEGDASDFHEQIADLQAQ---IAELKMQ-----LAKKEEELQAALARLD 1100

Query: 627  QE--EEEEILRLHQQKEQSLSSLRERL--QKAIEEEEARMREEESQRLSWLRAQVQSS-- 680
             E  ++   L+  ++ E  +S L+E L  ++A   +  + + +  + L  L+ +++ +  
Sbjct: 1101 DEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLD 1160

Query: 681  TQADEDQIRAEQEASLQKLREELESQQKAERASLE---QKNRQMLEQLKEEIEASEKSE- 736
            + A + ++RA++E  +  L++ L+ + ++  A ++   QK+ Q +E+L E++E  ++++ 
Sbjct: 1161 STATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKA 1220

Query: 737  -----------QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKH 785
                       + A  A + + L Q ++++E ++K+  A ++     EL+  CS  E   
Sbjct: 1221 NLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ-----ELQSKCSDGERAR 1275

Query: 786  REVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG 845
             E    L  K+ + Q + E+ +   L + E +  + +  VA     LSS L++ ++ ++ 
Sbjct: 1276 AE----LNDKVHKLQNEVES-VTGMLNEAEGKAIKLAKDVAS----LSSQLQDTQELLQE 1326

Query: 846  EHERRLD------KMKEEHQQVMAKAREQYEAEER---------------KQRAELLGHL 884
            E  ++L+      +++EE   +  +  E+ EA++                K++ +     
Sbjct: 1327 ETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 885  TGELERLQRAHERELETVRQEQHKRL---EDLRRRHREQERKLQDLELDL---------- 931
               LE  ++  ++E+E + Q+  ++    + L +     +++L DL +DL          
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNL 1446

Query: 932  ------------------------------ETRAKDVKARLAL-------LEVQEETARR 954
                                          E R K+ KA L+L       LE +EE  R 
Sbjct: 1447 EKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKA-LSLARALEEALEAKEELERT 1505

Query: 955  EKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQAR---KLKL 1011
             K    +++  V+ K +     H+  +  +   T + +   QL E+ DELQA    KL+L
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565

Query: 1012 ESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENN----------ASPHFEPD 1060
            E  +  L+ Q ++ LQ      E + ++ Q  L E   E  +          A    E D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625

Query: 1061 LHIEDLR-------KSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSA 1113
            L   +L+       +     Q +++ + +   + +L     S   ++          +S 
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSL 1685

Query: 1114 KEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKE----T 1169
            +  L+Q    +   + A K A    + ELA  +E+A    G  AL+D ++ LE       
Sbjct: 1686 EADLMQLQEDLAAAERARKQADLE-KEELA--EELASSLSGRNALQDEKRRLEARIAQLE 1742

Query: 1170 RHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEAS 1205
              L+E +  M    + ++K  ++  QL + L  E S
Sbjct: 1743 EELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778



 Score =  103 bits (257), Expect = 1e-21
 Identities = 169/800 (21%), Positives = 336/800 (42%), Gaps = 112/800 (14%)

Query: 446  IEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK 505
            +ED  DS ++Q EL++K+ + +   L   L  E R+         + +  +    Q   +
Sbjct: 1155 LEDTLDSTATQQELRAKREQEVTV-LKKALDEETRSHE------AQVQEMRQKHAQAVEE 1207

Query: 506  EAEELGEDSAASLSLQLSLQREQAPSPPAACE-------------KGKEQHSQAEEL--- 549
              E+L +   A  +L  + Q  +  +   A E             K K+  +Q +EL   
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267

Query: 550  -GPGQEEAEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQD 606
               G+    +  +KV    +    V+  +   E  A       A+L +  +   ++L+++
Sbjct: 1268 CSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEE 1327

Query: 607  QRHLLESKQEKMQQLREKL--CQEEEEEILRLHQQKEQSLSSL-------RERLQ----- 652
             R  L +   K++QL E+    Q++ +E +   Q  E+ +S+L       +++LQ     
Sbjct: 1328 TRQKL-NVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAST 1386

Query: 653  -KAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             +A+EE + R ++E          +  +  + ++ + R +QE  L  L  +L++Q++   
Sbjct: 1387 VEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQE--LDDLVVDLDNQRQLV- 1443

Query: 712  ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEK--E 769
            ++LE+K R+  + L EE   S K         +++A  + RE+ E +       LE+  E
Sbjct: 1444 SNLEKKQRKFDQLLAEEKNISSKYADE-----RDRAEAEAREK-ETKALSLARALEEALE 1497

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               ELER    L+A+  ++VSS     ++   K   +L+K    +E ++ +    +   E
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSS-----KDDVGKNVHELEKSKRALETQMEEMKTQLEELE 1552

Query: 830  HELSSL------LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQR 877
             EL +       L    Q ++G+ ER L   D+  EE ++ + +   +YE E   ERKQR
Sbjct: 1553 DELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQR 1612

Query: 878  AELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            A     L    ++      ++LE       K  E+  ++ R+ + +++D + +LE     
Sbjct: 1613 A-----LAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARAS 1667

Query: 938  VKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQL 997
                 A  +  E+ A+  +  L+ +Q  +A           + EE  +E    L     L
Sbjct: 1668 RDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNAL 1727

Query: 998  REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            ++    L+AR  +LE +   L+ +   ++     +    Q+ + L  E+  E + A  + 
Sbjct: 1728 QDEKRRLEARIAQLEEE---LEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN- 1783

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
                  E  R+ L   Q KE+ S L +      ++          ++A    +   +E +
Sbjct: 1784 ------ESARQQL-ERQNKELRSKLHE------MEGAVKSKFKSTIAALEAKIAQLEEQV 1830

Query: 1118 VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
             Q+    R +Q A K+ +Q             KD    K L+++   +E E +  ++ K 
Sbjct: 1831 EQEA---REKQAATKSLKQ-------------KD----KKLKEILLQVEDERKMAEQYKE 1870

Query: 1178 AMRKGHNLLKKKEEKLNQLE 1197
               KG+  +K+ + +L + E
Sbjct: 1871 QAEKGNARVKQLKRQLEEAE 1890



 Score =  102 bits (254), Expect = 3e-21
 Identities = 192/889 (21%), Positives = 355/889 (39%), Gaps = 167/889 (18%)

Query: 232  HSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADS 291
            +++ + +R L   I  L  D + E + R    ++K+D+  + +A                
Sbjct: 1107 NNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA---------------- 1150

Query: 292  SLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDT 351
             L + +      +  +  L  K E E +        V  KA    +   +A  +E  +  
Sbjct: 1151 -LKTELEDTLDSTATQQELRAKREQEVT--------VLKKALDEETRSHEAQVQEMRQKH 1201

Query: 352  VDAGEEGSRREEAAKEPK----KKASALEEGSSDASQELEIS-------EHMKEPQLSDS 400
              A EE + + E  K  K    K    LE+ ++D + EL +        EH K+   +  
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 401  IASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ 460
                 K   G           H L  +V S  + G   +A+    I+   D  S   +LQ
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVES--VTGMLNEAEGK-AIKLAKDVASLSSQLQ 1318

Query: 461  SKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSL 520
              Q    EE         ++     +    EEE     +   E  EA++  E   ++L++
Sbjct: 1319 DTQELLQEET-------RQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNI 1371

Query: 521  QLSLQREQAP---SPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRS 577
            QLS  +++     S   A E+GK++          Q+E E+  ++               
Sbjct: 1372 QLSDSKKKLQDFASTVEALEEGKKRF---------QKEIENLTQQYE------------- 1409

Query: 578  TEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLH 637
             E  A  ++L +   +  +E    V++ D +  L S  EK Q+  ++L  EE+    +  
Sbjct: 1410 -EKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYA 1468

Query: 638  QQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS------------- 679
             +++++ +  RE+  KA+      EE    +EE  +    L+A+++              
Sbjct: 1469 DERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVH 1528

Query: 680  ----------------STQADE--DQIRAEQEASL------QKLREELESQQKAERASLE 715
                             TQ +E  D+++A ++A L      Q L+ + E   +A     E
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588

Query: 716  QKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAVATLE 767
            +K RQ+  QL E E E  ++ +Q AL AA +K L+   + LE +       R+EA+  L 
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648

Query: 768  KEHSA--ELERLCSSLEAKHREVVSSLQKKIQEAQQKEE--AQLQKCLGQVEHRVHQKSY 823
            K  +   + +R      A   E+ ++ ++  ++A+  E    QLQ+ L   E    Q   
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708

Query: 824  HVAGYEHELSSLL--REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
                   EL+S L  R   Q+ +   E R+ +++EE ++      EQ   E    R    
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEE------EQGNMEAMSDRVR-- 1760

Query: 882  GHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD---- 937
               T + E+L      E  T ++ +  R + L R+++E   KL ++E  ++++ K     
Sbjct: 1761 -KATQQAEQLSNELATERSTAQKNESAR-QQLERQNKELRSKLHEMEGAVKSKFKSTIAA 1818

Query: 938  VKARLALLEVQEETARREKQ------------------QLLDVQRQVALKSEEATATH-- 977
            ++A++A LE Q E   REKQ                  Q+ D ++      E+A   +  
Sbjct: 1819 LEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNAR 1878

Query: 978  -----QQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
                 +QLEEA++E   +  + ++L+  LDE       +  +V+ L+++
Sbjct: 1879 VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score =  125 bits (315), Expect = 2e-28
 Identities = 178/837 (21%), Positives = 363/837 (43%), Gaps = 131/837 (15%)

Query: 474  PLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQR-EQAPSP 532
            PLP  E    P   + T+EE P+         + E + ED  +  +L+   QR ++  + 
Sbjct: 247  PLPQLE----PQAEVFTKEENPES--------DGEPVVEDGTSVKTLETLQQRVKRQENL 294

Query: 533  PAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAA- 591
               C++  + H +   L   ++EA   +    +     +  ++   E      QL +A  
Sbjct: 295  LKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIK-DLHMAEKTKLITQLRDAKN 353

Query: 592  -LKAMEEAVAQVLEQDQRHL---LESKQEKMQQLREKLCQ--EEEEEILRLHQQKEQSLS 645
             ++ +E+    V+ + +R +   LE K+E++ QLR ++ Q   + EE   L +QKE+S  
Sbjct: 354  LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEE---LREQKEKSER 410

Query: 646  SLRERLQKAI----EEEEARMR-----EEESQRLSWLRAQVQSSTQADEDQIRAE----- 691
            +  E L+KA+    + EEAR +     +E+ + +     + + S Q +  +++ E     
Sbjct: 411  AAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVM 470

Query: 692  ------QEASLQKLRE-ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAK 744
                  Q A LQKL E EL  +++     L+ + R+  EQ+K  +E S+ SE   ++  K
Sbjct: 471  KKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQ-SEYLKISQEK 529

Query: 745  EKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKE- 803
            E+      E+LE ++K A+ T  +    +L++   +   +  E+ SSL+K +QE + +  
Sbjct: 530  EQQESLALEELELQKK-AILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK 588

Query: 804  ------EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEE 857
                  EA+  K   ++   V +    +   +H+  +L  EK Q ++ +++  ++K++E+
Sbjct: 589  DLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREK 648

Query: 858  HQQ---VMAKARE---QYEAEERKQRA--------ELLGHLTGELERLQRAHER------ 897
             +Q    + K +E   Q   EE  ++           L  L+ EL  + +A  +      
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELS 708

Query: 898  ----ELETVRQEQHKRLEDLRRRHREQ---------------ERKLQD----LELDLETR 934
                + + ++QE   ++++ +  H++Q               E+ L+D    LEL L+ R
Sbjct: 709  VLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768

Query: 935  AKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQS- 993
             K +K   A +E  E   +R + +L     ++ +     +ATH+Q +  +++   L Q  
Sbjct: 769  DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828

Query: 994  -----------------NQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLE--- 1033
                               Q +++  EL A K++++  +  L+ Q+ ++++   SL    
Sbjct: 829  LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888

Query: 1034 ----AEAQKKQHLLREVTVEENNASPHFE--PDLHIEDLRKSLGTNQTKEVSSSLSQSKE 1087
                 +  K+Q   +++ VE+ N            IE L + L     KE S  +   + 
Sbjct: 889  ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKL---SAKEDSIHILNEEY 945

Query: 1088 DLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRR-RQTALKAAQQHWRHELASAQ 1146
            +    +           A+ +     K+ L Q+ +  +    TAL+ +Q+  +      +
Sbjct: 946  ETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLE 1005

Query: 1147 EVAKDPPGIK-ALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWE 1202
                +  GI  A+  +  N +++   L E+    R+ ++++   E+KLNQ    L E
Sbjct: 1006 MAQANSAGISDAVSRLETNQKEQIESLTEVH--RRELNDVISIWEKKLNQQAEELQE 1060



 Score = 96.7 bits (239), Expect = 1e-19
 Identities = 173/851 (20%), Positives = 351/851 (41%), Gaps = 124/851 (14%)

Query: 438  RQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEER------AQSPPRSLATE 491
            +Q QQ L       + S+   ++S+ S    E+L    P+ E       AQ     + + 
Sbjct: 14   QQLQQALAPAQASSNSSTPTRMRSRTSS-FTEQLDEGTPNRESGDTQSFAQKLQLRVPSV 72

Query: 492  EEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGP 551
            E   + P  +  ++ + +   +S    S + SL R    S  A+ +   +  S+AE+L  
Sbjct: 73   ESLFRSPIKESLFRSSSK---ESLVRTSSRESLNRLDLDSSTASFDPPSDMDSEAEDL-V 128

Query: 552  GQEEAEDPEEKVAV--SPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH 609
            G  ++ + E+ +         +S        +    Q+ +   K ++  ++Q  ++  R 
Sbjct: 129  GNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRR 188

Query: 610  LLESKQE-KMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEE-EEARMREEES 667
            + E ++E +M Q  +K  QEE +  L   ++K+Q +S L+ ++    +      M  +  
Sbjct: 189  IAELREELQMDQQAKKHLQEEFDASL---EEKDQYISVLQTQVSLLKQRLRNGPMNVDVL 245

Query: 668  QRLSWLRAQVQSSTQADEDQIRAE---------------------QEASLQKLREELESQ 706
            + L  L  Q +  T+ +  +   E                     QE  L++ +E ++S 
Sbjct: 246  KPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSH 305

Query: 707  QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLR------EQLEGERK 760
             K +   L  +   + EQL E ++  EK +   + A K K + QLR      EQLE ++ 
Sbjct: 306  -KEQCTLLTSEKEALQEQLDERLQELEKIKDLHM-AEKTKLITQLRDAKNLIEQLEQDKG 363

Query: 761  EAVA--------TLE-------------KEHSAELERLCSSLEAKHREVVSSLQKKIQEA 799
              +A        TLE             K+ + + E L    E   R     L+K +  A
Sbjct: 364  MVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTA 423

Query: 800  QQKEEAQLQKCLGQVEHRVHQ----KSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK 855
            Q+ EEA+ +K   +++ ++              + ELS + +E    ++   E ++ K++
Sbjct: 424  QKTEEAR-RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQ 482

Query: 856  EEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRR 915
            + H++ +A+  ++   + + +  E    +   LE+ Q  + +  +   Q++   LE+L  
Sbjct: 483  KLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELEL 542

Query: 916  RHR----EQERKLQDLELDLETRAKDVKARLALLEVQ---EETARREKQQLLDVQRQVAL 968
            + +    E E KL+DL+ + ET       R  +LE++   E++ +  K Q  D+   V L
Sbjct: 543  QKKAILTESENKLRDLQQEAET------YRTRILELESSLEKSLQENKNQSKDL--AVHL 594

Query: 969  KSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKH 1028
            ++E+     +     +K  T L    + L+   D L   KL++  Q    Q + ++L++ 
Sbjct: 595  EAEKNKHNKEITVMVEKHKTEL----ESLKHQQDALWTEKLQVLKQ--QYQTEMEKLREK 648

Query: 1029 FSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKED 1088
                +    K + ++ +  +EE N     + D+   +L     +++  EV  +  + +E+
Sbjct: 649  CEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESL--SSELSEVLKARHKLEEE 706

Query: 1089 L----------------YLDSLSSHN---VWHLLSAEGVALRSAKEFLVQQTRSMRRRQT 1129
            L                 +D   +H+   V  ++    V+++  ++ L  Q   +   + 
Sbjct: 707  LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQL---EL 763

Query: 1130 ALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKK 1189
             LK   +H +   A  + +  D   IK  E     L++ +  LD  +S     H   K  
Sbjct: 764  LLKERDKHLKEHQAHVENLEAD---IKRSEG---ELQQASAKLDVFQSYQSATHEQTKAY 817

Query: 1190 EEKLNQLESSL 1200
            EE+L QL+  L
Sbjct: 818  EEQLAQLQQKL 828



 Score = 94.0 bits (232), Expect = 1e-18
 Identities = 196/963 (20%), Positives = 395/963 (41%), Gaps = 160/963 (16%)

Query: 310  LPEKEENEKSEPKICRNLVTPKA---DPTGSEPAKASEKEA-----PEDTVDAGEEGSRR 361
            L EKE   KS      +LVT K       G++   ASEKE+      ++  +     +  
Sbjct: 1299 LEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLM 1358

Query: 362  EEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISE 421
            +E  KE K + S+L +  +D + +L+ S  + E + +  I+S  K +         ++ +
Sbjct: 1359 KEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAA--ISSLRKQYDEEKCELLDQVQD 1416

Query: 422  HLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERA 481
                VD LS                ++K  +    D+  +K S+  ++  S    H+   
Sbjct: 1417 LSFKVDTLS----------------KEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTV 1460

Query: 482  QSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAA--CEKG 539
            +     L  +             KEA E  E        Q++L +E+         C KG
Sbjct: 1461 KELQIQLELKS------------KEAYEKDE--------QINLLKEELDQQNKRFDCLKG 1500

Query: 540  KEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSP-EVRSTEPVAPPEQLSEAA--LKAME 596
            + +  +++      E+ E   E    S T  +   E   T+     E L+E        +
Sbjct: 1501 EMEDDKSK-----MEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQK 1555

Query: 597  EAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQ----------------- 639
            +   + L Q  +H  E  +EK  +++E      EE+IL L  Q                 
Sbjct: 1556 DIEHKELVQKLQHFQELGEEKDNRVKEA-----EEKILTLENQVYSMKAELETKKKELEH 1610

Query: 640  -------KEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQ 692
                   KE+ L +L +RL+     + A ++ +  Q+++ ++ Q+ S  +  E+Q +   
Sbjct: 1611 VNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGT 1670

Query: 693  EASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLR 752
            E+ L +L  +L+ +++ E   LE+K + +     E +     ++  A    +E+A  Q  
Sbjct: 1671 ESHLSELNTKLQERER-EVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGC 1729

Query: 753  EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSS------------LQKKIQEAQ 800
             Q   E K +V    + +  E E+L   +  +  E VSS            ++ +  EA+
Sbjct: 1730 VQKTYEEKISVL---QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAK 1786

Query: 801  QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEG-----EHERRLDKMK 855
            Q E+   Q  +G ++  + +K        ++  SL+  +  E EG     + ++ L+ + 
Sbjct: 1787 QHED---QSMIGHLQEELEEK--------NKKYSLIVAQHVEKEGGKNNIQAKQNLENVF 1835

Query: 856  EEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE--TVRQEQHKRLEDL 913
            ++ Q+ + +     +  E+K     +  L   L R +  H  E+E  T + E+ + L+ +
Sbjct: 1836 DDVQKTLQEKELTCQILEQK-----IKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQM 1890

Query: 914  RRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEA 973
              R++  E     LE + E ++K    +  LL   E      + +L   +R+     +E 
Sbjct: 1891 DGRNKPTEL----LEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEI 1946

Query: 974  TATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQS--QQLQKHFSS 1031
                + L   +KEH    Q  + L++  D+ +  K+K E +   L+  S  +QL + F++
Sbjct: 1947 VRLQKDLRMLRKEHQ---QELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNT 2003

Query: 1032 LEAEAQKKQHLLREVTVEEN-NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLY 1090
                AQK+Q L  E+T++E  N +   E +L +E  ++     +T ++   +++  +DL 
Sbjct: 2004 --QLAQKEQEL--EMTIKETINKAQEVEAEL-LESHQE-----ETNQLLKKIAEKDDDLK 2053

Query: 1091 LDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAK 1150
              +     +          L + +E   + T  +R  QT L+  Q+ ++ +L   +    
Sbjct: 2054 RTAKRYEEI----------LDAREE---EMTAKVRDLQTQLEELQKKYQQKLEQEENPGN 2100

Query: 1151 DPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            D   I    +++  L ++T  + + K   ++    +   E++L + E +++         
Sbjct: 2101 DNVTIM---ELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYK 2157

Query: 1211 GGS 1213
            GG+
Sbjct: 2158 GGN 2160



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 135/712 (18%), Positives = 292/712 (41%), Gaps = 55/712 (7%)

Query: 521  QLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEP 580
            QL  +  Q  S  A  E    +    ++ G  Q++A   +E         +S  + +   
Sbjct: 1298 QLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTL 1357

Query: 581  VAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQK 640
            +    +  +  + ++ + +  +  Q Q  +  S++E       K   EE+ E+L   Q  
Sbjct: 1358 MKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDL 1417

Query: 641  EQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLR 700
               + +L +    A+E+      ++ S + S  + + QS     ++ ++  Q     K +
Sbjct: 1418 SFKVDTLSKEKISALEQV-----DDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSK 1472

Query: 701  EELESQQKAE--RASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGE 758
            E  E  ++    +  L+Q+N++  + LK E+E  +   +   +  + +   Q    +E E
Sbjct: 1473 EAYEKDEQINLLKEELDQQNKR-FDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELE 1531

Query: 759  RKEAVATLEKEHSAE-LERLCSSLEAKHREVVSSLQ--KKIQEAQQKEEAQLQKCLGQVE 815
                  T+E E   E L+      + +H+E+V  LQ  +++ E +     + ++ +  +E
Sbjct: 1532 DHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLE 1591

Query: 816  HRVHQKSYHVAGYEHELSSL---LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE 872
            ++V+     +   + EL  +   ++ K +E++       D+++ E    +A+ + + E +
Sbjct: 1592 NQVYSMKAELETKKKELEHVNLSVKSKEEELKALE----DRLESESAAKLAELKRKAEQK 1647

Query: 873  ERKQRAELLGHLTGELERLQR---AHERELETVRQEQHKRLEDLRRRHREQERKLQDLEL 929
                + +LL  +  + E+ ++   +H  EL T  QE+ + +  L  + +  E   Q   L
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS-QSETL 1706

Query: 930  DLETRAKDVKARLALLEVQEE--TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEH 987
             +   AK+V A     E   +    +  ++++  +QR +  K +      Q+ EE    H
Sbjct: 1707 IVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSH 1766

Query: 988  THLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVT 1047
              +    Q+    L+  +A++ + +S +  LQ + ++  K +S + A+  +K+     + 
Sbjct: 1767 FEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQ 1826

Query: 1048 VEEN--NASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSA 1105
             ++N  N     +  L  ++L   +   + KE+ S L + KE             H +  
Sbjct: 1827 AKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKE------------VHRVEM 1874

Query: 1106 EGVALRSAKEFLVQQ------TRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIK--A 1157
            E +  +  K   +QQ         +    T  K+     + +L S  E   +    K   
Sbjct: 1875 EELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAG 1934

Query: 1158 LEDMRKNLEKETRHLDEMKSAMRKGH----NLLKK-----KEEKLNQLESSL 1200
             E  ++ L KE   L +    +RK H     +LKK     +EEK+ Q +  L
Sbjct: 1935 AEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDL 1986



 Score = 80.5 bits (197), Expect = 1e-14
 Identities = 184/964 (19%), Positives = 379/964 (39%), Gaps = 104/964 (10%)

Query: 313  KEENEKSEPKI-CRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            +E NEK+  K+  +           SE  KA  K   E +V   +    ++E   +  ++
Sbjct: 669  EEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQ 728

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSR---ISEHLLDVDV 428
             +  ++      +E E+S    E  L D I       + L+   + R   + EH   V+ 
Sbjct: 729  KNHHQQQVDSIIKEHEVSIQRTEKALKDQI-------NQLELLLKERDKHLKEHQAHVEN 781

Query: 429  LSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
            L   +  +  + QQ      K D   S      +Q+K  EE+L+       + Q     L
Sbjct: 782  LEADIKRSEGELQQASA---KLDVFQSYQSATHEQTKAYEEQLA-------QLQQKLLDL 831

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEE 548
             TE         + E ++ +   E  A  + +Q  +Q+ +  +     +          +
Sbjct: 832  ETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESK 891

Query: 549  LGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQV-LEQDQ 607
            L  G +E E  ++ +       +              Q+ E   K +E    ++  ++D 
Sbjct: 892  LEDGNKEQEQTKQILVEKENMIL--------------QMREGQKKEIEILTQKLSAKEDS 937

Query: 608  RHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
             H+L  + E   + +EK  ++ +++   + +  ++ L     +L+K +E     + ++E 
Sbjct: 938  IHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEK 997

Query: 668  QRLSWLRAQVQSSTQADED---QIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQ 724
            Q  + +    Q+++    D   ++   Q+  ++ L E    +     +  E+K  Q  E+
Sbjct: 998  QFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE 1057

Query: 725  LKE--EIEASEKSEQAALNAAKEKAL------QQLREQLEGERKEAVATLEKEHSAELER 776
            L+E  EI+  EK ++ A    K+K L      +++ +++   ++E V     +    L  
Sbjct: 1058 LQEIHEIQLQEKEQEVA--ELKQKILLFGCEKEEMNKEITWLKEEGV-----KQDTTLNE 1110

Query: 777  LCSSLEAKHREVVSSLQ--KKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSS 834
            L   L+ K   V S  Q   K++   +K E  L K L +      Q          EL  
Sbjct: 1111 LQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLV--------ELKM 1162

Query: 835  LLREKRQEVEGEHERRLDKMKEEHQQVMA------KAREQYEAEERKQRAEL---LGHLT 885
            L  E +++V  E   +L    EE Q + +      K+ E    E +K   EL   L    
Sbjct: 1163 LAEEDKRKV-SELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICC 1221

Query: 886  GELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945
             + E L  A   EL  +   +   +       + +  K+++  L       +++A+L  L
Sbjct: 1222 KKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQL 1281

Query: 946  EVQEETA----RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREIL 1001
              ++ T     ++   QL + + Q+     +  +   + E  QKE  +  Q+  +    +
Sbjct: 1282 TEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCI 1341

Query: 1002 DELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDL 1061
             +L+    +  + V L++ + ++ +   SSL  +       L ++ V+  N+    E + 
Sbjct: 1342 TQLKKELSENINAVTLMKEELKEKKVEISSLSKQ-------LTDLNVQLQNSISLSEKEA 1394

Query: 1062 HIEDLRKSLGTNQTKEVSSSLSQSKEDL--YLDSLSSHNVWHLLSAEGVALRSAKEFLVQ 1119
             I  LRK     Q  E    L    +DL   +D+LS   +  L   +  + + ++     
Sbjct: 1395 AISSLRK-----QYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKA 1449

Query: 1120 QTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAM 1179
            Q+R  + + T  +   Q    EL S +   KD    + +  +++ L+++ +  D +K  M
Sbjct: 1450 QSRFTQHQNTVKELQIQ---LELKSKEAYEKD----EQINLLKEELDQQNKRFDCLKGEM 1502

Query: 1180 RKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSP 1239
                + ++KKE   + LE+ L  + +    L    T+K  T ++  ++ +    ++    
Sbjct: 1503 EDDKSKMEKKE---SNLETELKSQTARIMELEDHITQK--TIEIESLNEVLKNYNQQKDI 1557

Query: 1240 PHRE 1243
             H+E
Sbjct: 1558 EHKE 1561


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score =  125 bits (313), Expect = 4e-28
 Identities = 174/761 (22%), Positives = 330/761 (43%), Gaps = 90/761 (11%)

Query: 571  VSPEVRSTEPVAPPEQLSEAALKAME-----EAVAQVLEQDQRHLLESKQEKMQQLREK- 624
            V P ++ T      +   E  LK  E     E   + +E+  + LLE K    +QL+ + 
Sbjct: 841  VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAET 900

Query: 625  -LCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQA 683
             L  E EE   RL   K+Q L  +   L+  +EEEE R +  ++++   ++A +Q   + 
Sbjct: 901  ELFAEAEEMRARL-AAKKQELEEILHDLESRVEEEEERNQILQNEKKK-MQAHIQDLEEQ 958

Query: 684  DEDQIRAEQEASLQKLREELESQQKAERASL-EQKNRQMLEQLK-EEIEASEKSEQAALN 741
             +++  A Q+  L+K+  E + ++  E   L E +N + +++ K  E   +E S Q A  
Sbjct: 959  LDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEE 1018

Query: 742  AAKEKALQQLREQLEGERKEAVATLEKEHSA--ELERLCSSLEAKHREV---VSSLQKKI 796
              K K L ++R + E    +    L+KE     ELE+    L+ +  ++   ++ LQ +I
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQI 1078

Query: 797  QEAQ---QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERR--L 851
             E +    K+E +LQ  L + +     K+ +      EL + + E +++ E E   R   
Sbjct: 1079 DELKLQLAKKEEELQGALARGDDETLHKN-NALKVVRELQAQIAELQEDFESEKASRNKA 1137

Query: 852  DKMKEEHQQVMAKAREQYE---------AEERKQRAELLGHLTGELERLQRAHERELETV 902
            +K K +  + +   + + E          E R +R + +  L   LE   + HE +++ +
Sbjct: 1138 EKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDM 1197

Query: 903  RQEQHKRLEDLRRRHREQERKLQDLELD---LETRAKDVKARLALLEVQEETARREKQQL 959
            RQ     LE+L  +  + +R   +LE +   LET  K++   + +L+ Q +     K++ 
Sbjct: 1198 RQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQ-QVKAESEHKRKK 1256

Query: 960  LDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQ 1019
            LD Q Q           H ++ E  +    L +   +L+  LD        + + ++  +
Sbjct: 1257 LDAQVQ---------ELHAKVSEGDRLRVELAEKASKLQNELD-------NVSTLLEEAE 1300

Query: 1020 AQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVS 1079
             +  +  K  +SLE++ Q  Q LL+E T ++ N S        +E+ + SL   Q +E  
Sbjct: 1301 KKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIR---QLEEEKNSLQEQQEEEEE 1357

Query: 1080 SSLSQSKEDLYLDSLSSHNVWHLLSAEGV--ALRSAKEFLVQQTRSMRRRQTALKAAQQH 1137
            +  +  K+ L L S  +     +    G   +L  AK+ L++   ++ +R          
Sbjct: 1358 ARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQR---------- 1407

Query: 1138 WRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQL- 1196
               E A A +          LE  +  L++E   L       R+  + L+KK++K +QL 
Sbjct: 1408 -LEEKALAYD---------KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLL 1457

Query: 1197 --ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSS--ESSESFSPPHREWWRQQRIDS 1252
              E S+    ++E     +  ++  T  LS   +L    E+ E F   +    +Q R D 
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN----KQLRADM 1513

Query: 1253 TPSLTS-----RKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
               ++S     + +H L  S R +  Q+  + + L+ L  +
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDE 1554



 Score =  117 bits (294), Expect = 6e-26
 Identities = 206/987 (20%), Positives = 407/987 (41%), Gaps = 164/987 (16%)

Query: 190  KTSAYTKGLLGSIYEDKTALSLLGLGEETNEEDEE----ESDNQSVHSSS--EPLRNLHL 243
            K    T  L   I E +  +  L L     EE+ +      D++++H ++  + +R L  
Sbjct: 1059 KLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQA 1118

Query: 244  DIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKGRQG 303
             I  L  DFE E++ R    ++K+D+S + +A                 L + +      
Sbjct: 1119 QIAELQEDFESEKASRNKAEKQKRDLSEELEA-----------------LKTELEDTLDT 1161

Query: 304  SGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREE 363
            + A+  L  K E E +E K        KA    ++  +A  ++  +    A EE S + E
Sbjct: 1162 TAAQQELRTKREQEVAELK--------KALEEETKNHEAQIQDMRQRHATALEELSEQLE 1213

Query: 364  AAKEPK----KKASALEEGSSDASQELEISEHMK--EPQLSDSIASDPKSFHG-LDFGFR 416
             AK  K    K    LE  + + + E+++ + +K         + +  +  H  +  G R
Sbjct: 1214 QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDR 1273

Query: 417  SRI------SEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEER 470
             R+      S+   ++D +S +L     +  +  GI+   D+ S + +LQ  Q    EE 
Sbjct: 1274 LRVELAEKASKLQNELDNVSTLL-----EEAEKKGIKFAKDAASLESQLQDTQELLQEET 1328

Query: 471  LSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAP 530
                    ++     R    EEE     E Q E +EA +  E    +L  QL+  +++  
Sbjct: 1329 -------RQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVD 1381

Query: 531  SPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEA 590
                  E  +E  ++ + L   +  ++  EEK                      ++L + 
Sbjct: 1382 DDLGTIESLEE--AKKKLLKDAEALSQRLEEKALAY------------------DKLEKT 1421

Query: 591  ALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRER 650
              +  +E     ++ D +  + S  EK Q+  ++L  EE+    R  ++++++ +  RE+
Sbjct: 1422 KNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREK 1481

Query: 651  LQKAIE-----EEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELES 705
              KA+      EE    +EE  ++   LRA ++    + +D         + K   ELE 
Sbjct: 1482 ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDD---------VGKNVHELEK 1532

Query: 706  QQKAERASLEQKNRQMLEQLKEEIEASEKSE------QAALNAAKEKALQQLREQLEGER 759
             ++A    +E+  R  LE+L++E++A+E ++        A+ A  E+ LQ   EQ E E+
Sbjct: 1533 SKRALEQQVEEM-RTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNE-EK 1590

Query: 760  KEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQ---KCLGQVEH 816
            K  +    +E  AELE      E K R +  + +KK++   +  EAQ++   K   +V  
Sbjct: 1591 KRLLIKQVRELEAELED-----ERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIK 1645

Query: 817  RVHQKSYHVAGYEHELSSLLREKRQEV---EGEHERRLDKMKEEHQQVM------AKARE 867
            ++ +    +  Y+ EL    R  R E+     E E++L  ++ E  Q+        +AR 
Sbjct: 1646 QLRKLQAQMKDYQRELEE-ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704

Query: 868  QYEAEERKQRAELLGHLTGE---LERLQRAHER--ELETVRQEQHKRLEDLRRRHREQER 922
              E E  +   E+    +G+   L+  +R   R  +LE   +E+   +E L  R R+   
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764

Query: 923  KLQDLELD-----------------LETRAKDVKARLALLEVQ-----EETARREKQQLL 960
            ++  L  +                 LE + K++KA+L  LE       + T    + ++ 
Sbjct: 1765 QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIG 1824

Query: 961  DVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQA 1020
             ++ Q+  +++E  A ++ +   +K+   +    +  R   D+ + +  K  +++  L+ 
Sbjct: 1825 QLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKR 1884

Query: 1021 QSQQLQKHFSSLEAEAQKKQH-----------LLREVTVEEN----------NASPHFEP 1059
            Q ++ ++  +   A  +K Q            L REV+  +N          ++S     
Sbjct: 1885 QLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGRR 1944

Query: 1060 DLHIEDLRKSLGTNQTKEVSSSLSQSK 1086
             LH+E     L  + T+  +S +++++
Sbjct: 1945 QLHLEGASLELSDDDTESKTSDVNETQ 1971



 Score =  110 bits (274), Expect = 1e-23
 Identities = 214/1049 (20%), Positives = 423/1049 (40%), Gaps = 141/1049 (13%)

Query: 313  KEENEK--SEPKICRNLVTPKADPTGSEPAKASE----KEAPEDTVDAGEEGSRREEAAK 366
            +++N K   E K+  + +   +     E  KA      +   E  +   EE  ++EE  +
Sbjct: 991  EDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTR 1050

Query: 367  EPKKKASALEEGSSDASQ-----------ELEISEHMKEPQLSDSIA-SDPKSFHGLDF- 413
            +  +KA    +G +   Q           EL++    KE +L  ++A  D ++ H  +  
Sbjct: 1051 QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNAL 1110

Query: 414  ----GFRSRISEHLLDVDVLSPVLGGACRQAQQ--------PLGIEDKDDSQSSQDELQS 461
                  +++I+E   D +        A +Q +            +ED  D+ ++Q EL++
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170

Query: 462  KQS-------KGLEERLSPPLPHEERAQSPPRSLATE-EEPPQGPEGQPEWKEAEELGED 513
            K+        K LEE       HE + Q   +  AT  EE  +  E    +K   E  + 
Sbjct: 1171 KREQEVAELKKALEEETKN---HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQ 1227

Query: 514  SAASLSLQLSLQREQAPSPPAACE-KGKEQHSQAEELGPGQEEAEDPEEKVAVSPTP--- 569
               + + +L+ + +      A  E K K+  +Q +EL     E +    ++A   +    
Sbjct: 1228 GLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQN 1287

Query: 570  ---PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESK------QEKMQQ 620
                VS  +   E          A+L++  +   ++L+++ R  L         +E+   
Sbjct: 1288 ELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347

Query: 621  LREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSS 680
            L+E+  QEEEEE  +  +++  +L S     +K ++++   +   E  +   L+     S
Sbjct: 1348 LQEQ--QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALS 1405

Query: 681  TQADEDQIRAEQ-EASLQKLREELES------QQKAERASLEQKNRQMLEQLKEEIEASE 733
             + +E  +  ++ E +  +L++EL+        Q+   ++LE+K ++      +++ A E
Sbjct: 1406 QRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKF-----DQLLAEE 1460

Query: 734  KSEQAALNAAKEKALQQLREQLEGERKEAVATLEK--EHSAELERLCSSLEAKHREVVSS 791
            KS  A     +++A  + RE+ E +       LE+  E   E ER    L A   +++SS
Sbjct: 1461 KSISARYAEERDRAEAEAREK-ETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSS 1519

Query: 792  LQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL------LREKRQEVEG 845
                 ++   K   +L+K    +E +V +    +   E EL +       L    Q ++ 
Sbjct: 1520 -----KDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKA 1574

Query: 846  EHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQRAELLGHLTGELERLQRAHEREL 899
            + ER L   D+  EE ++++ K   + EAE   ERKQRA     L    ++      ++L
Sbjct: 1575 QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRA-----LAVASKKKMEIDLKDL 1629

Query: 900  ETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQL 959
            E   +  +K  +++ ++ R+ + +++D + +LE          A  +  E+  +  + ++
Sbjct: 1630 EAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689

Query: 960  LDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQ 1019
            L +Q ++A          Q+ +E   E T+       L +    L+AR  +LE +++  Q
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 1020 AQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVS 1079
            +  + L   F     +      L  E+  E + A          ++ R+ L   Q KE+ 
Sbjct: 1750 SNMELLNDRFRKTTLQVDT---LNAELAAERSAAQKS-------DNARQQL-ERQNKELK 1798

Query: 1080 SSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWR 1139
            + L +      L+          +SA    +   +E L Q+ +                 
Sbjct: 1799 AKLQE------LEGAVKSKFKATISALEAKIGQLEEQLEQEAK----------------- 1835

Query: 1140 HELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESS 1199
             E A+A ++ +     K L+++   +E E RH D+ K  M K +  +K+ + +L      
Sbjct: 1836 -ERAAANKLVRRTE--KKLKEIFMQVEDERRHADQYKEQMEKANARMKQLKRQL------ 1886

Query: 1200 LWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESFSPPHREWWRQQRIDSTPSLTSR 1259
              EEA +E T   +  +K +  +L D    +   S   S       R   I  + S + R
Sbjct: 1887 --EEAEEEATRANASRRK-LQRELDDATEANEGLSREVSTLKNRLRRGGPISFSSSRSGR 1943

Query: 1260 K-IHGLSHSLRQISSQLSSVLSILDSLNP 1287
            + +H    SL        S  S ++   P
Sbjct: 1944 RQLHLEGASLELSDDDTESKTSDVNETQP 1972



 Score =  106 bits (265), Expect = 1e-22
 Identities = 158/687 (22%), Positives = 311/687 (45%), Gaps = 79/687 (11%)

Query: 608  RHLLESKQEKMQQLREKLCQEEEEEILRL-HQQKEQSLSSLRERLQKAIEEEEARMREEE 666
            R     KQ+++  L  K+ Q      L+L H Q  +  + ++  LQ   +EEE + ++EE
Sbjct: 803  RKAFAKKQQQLSAL--KVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEE 860

Query: 667  SQRLSWLRAQVQSSTQADE---DQIRAEQEASLQKLREELE-----SQQKAERASLEQKN 718
              ++   + +V+   +  E    Q+  E+    ++L+ E E      + +A  A+ +Q+ 
Sbjct: 861  LLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQEL 920

Query: 719  RQMLEQLKEEIEASEKSEQAALNAAK--EKALQQLREQL---EGERK----EAVATLEKE 769
             ++L  L+  +E  E+  Q   N  K  +  +Q L EQL   EG R+    E V    K 
Sbjct: 921  EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQE-------AQQKEEAQLQKCLGQVEHRVHQKS 822
               E E L   LE ++ + +   +KK+ E       +Q  EE +  K L ++ ++   + 
Sbjct: 981  KKMEEEILL--LEDQNSKFIK--EKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK---QE 1033

Query: 823  YHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYE---AEERKQRAE 879
              ++  E  L     + RQE+E + +R+LD    + Q  +A+ + Q +    +  K+  E
Sbjct: 1034 VMISDLEERLKK-EEKTRQELE-KAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEE 1091

Query: 880  LLGHLT-GELERLQRAHE----RELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETR 934
            L G L  G+ E L + +     REL+    E  +  E  +    + E++ +DL  +LE  
Sbjct: 1092 LQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1151

Query: 935  AKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ-QLEEAQKEHTHLLQS 993
              +++  L     Q+E   + +Q++ ++++ +    EE T  H+ Q+++ ++ H   L  
Sbjct: 1152 KTELEDTLDTTAAQQELRTKREQEVAELKKAL----EEETKNHEAQIQDMRQRHATAL-- 1205

Query: 994  NQQLREILDELQARKLKLESQVDLLQAQSQQLQ---KHFSSLEAEAQKKQHLLREVTVEE 1050
             ++L E L++ +  K  LE     L+  +++L    K    ++AE++ K+  L +  V+E
Sbjct: 1206 -EELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKL-DAQVQE 1263

Query: 1051 NNASPHFEPDLHIEDLRK-SLGTNQTKEVSSSLSQ--------SKEDLYLDSLSSHNVWH 1101
             +A       L +E   K S   N+   VS+ L +        +K+   L+S    +   
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLES-QLQDTQE 1322

Query: 1102 LLSAE---GVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQ--------EVAK 1150
            LL  E    + L S    L ++  S++ +Q   + A+++   ++ + Q        +V  
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD 1382

Query: 1151 DPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
            D   I++LE+ +K L K+   L +        ++ L+K + +L Q    L  +   +  +
Sbjct: 1383 DLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQV 1442

Query: 1211 GGSPTKKAVTFD--LSDMDSLSSESSE 1235
              +  KK   FD  L++  S+S+  +E
Sbjct: 1443 ASNLEKKQKKFDQLLAEEKSISARYAE 1469


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
            sapiens]
          Length = 750

 Score =  122 bits (306), Expect = 3e-27
 Identities = 130/578 (22%), Positives = 279/578 (48%), Gaps = 46/578 (7%)

Query: 455  SQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK-EAEELGED 513
            + +EL+ K +K L+E+L      +   Q   + L  + E  +    Q + + EA+ LG++
Sbjct: 215  TDEELKEKNAK-LQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKE 273

Query: 514  SAASLSLQLSLQREQAPSPPAACEKGKEQH-SQAEELGPGQEEAEDPEEKVAVSPTPPVS 572
               S+S +L  Q E+        ++ +E+   Q E++   +E+ ++ EEK+         
Sbjct: 274  -LQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR-------- 324

Query: 573  PEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEE 632
                  E +   E+      + M E   ++  Q++  ++  K+EKM++ +E++  E+EE+
Sbjct: 325  ---EQEEKIREQEEKMRRQEEMMWEKEEKMRRQEE--MMWEKEEKMRR-QEEMMWEKEEK 378

Query: 633  ILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQ 692
            + R  +   +    +RE  +K  E+E+ R +EE+ Q    +R          E + R EQ
Sbjct: 379  MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIR----------EQEKRQEQ 428

Query: 693  EASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLR 752
            EA + +  E++  Q++     + ++ ++M  Q +E+I   EK  +      +E+  +Q  
Sbjct: 429  EAKMWRQEEKIREQEE----KIREQEKKMWRQ-EEKIHEQEKIREEEKRQEQEEMWRQ-- 481

Query: 753  EQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLG 812
            E+   E++E     EK H  E E++      K  E V   ++KI+E ++K   Q +K   
Sbjct: 482  EEKIHEQEEIWRQKEKMHEQE-EKI-----RKQEEKVWRQEEKIREQEEKIREQEEKMWR 535

Query: 813  QVEH-RVHQKSYHVAGYEHELSSLLRE-KRQEVEGEHERRLDKMKEEHQQVMAKAREQYE 870
            Q E  R  ++ +      HE   +  E KRQE E +  R+ +K++E+ ++V  +  +  E
Sbjct: 536  QEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIRE 595

Query: 871  AEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELD 930
             EE++Q  E       E  R Q    +E E   +EQ +++ +     +EQE K+ + E  
Sbjct: 596  QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655

Query: 931  LETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHL 990
            +  + + ++ +   +  QEE  R +++++ + + ++    E+     +Q E+  ++   +
Sbjct: 656  MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKI---REQEEMMQEQEEKMWEQEEKM 712

Query: 991  LQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKH 1028
             +  ++++E  ++++ ++ K+  Q   L+ Q +++Q+H
Sbjct: 713  CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEH 750



 Score =  117 bits (292), Expect = 1e-25
 Identities = 98/452 (21%), Positives = 226/452 (50%), Gaps = 29/452 (6%)

Query: 603  LEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARM 662
            L Q Q   +  ++EK+Q+  EK+ QE+EE+I    ++  +    +R + +   E+EE   
Sbjct: 294  LNQQQEEKMWRQEEKIQEWEEKI-QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMR 352

Query: 663  REEES--QRLSWLRAQVQSSTQADEDQIRAEQEA--SLQKLREELESQQKAERASLEQKN 718
            R+EE   ++   +R Q +   + +E   R E+      +K+RE  E   + E+   +++ 
Sbjct: 353  RQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEK 412

Query: 719  RQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 778
            RQ  E+++E+    ++ EQ A    +E+ +++  E++  + K+     EK H  E  R  
Sbjct: 413  RQEEEKIREQ---EKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIR-- 467

Query: 779  SSLEAKHREVVSSLQKKIQEAQQKEEAQLQK-CLGQVEHRVHQKSYHVAGYEHELSSLLR 837
               E + R+    + ++ ++  ++EE   QK  + + E ++ ++   V   E ++     
Sbjct: 468  ---EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQ-E 523

Query: 838  EKRQEVEGEHERRLDKMKEEHQ--QVMAKAREQYEAEERKQRAELLGHLTGELERLQRAH 895
            EK +E E +  R+ +K++E+ +  +   K  EQ +  E ++R E    +  + E+++   
Sbjct: 524  EKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE 583

Query: 896  E---------RELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLE 946
            E         RE E  RQEQ +++     + REQE K+Q+ E  +  + + ++ +  + +
Sbjct: 584  EKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ 643

Query: 947  VQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQA 1006
             QEE    +++++ + + +  ++ +E T   Q+ E+ +++   + +  +++RE  + +Q 
Sbjct: 644  EQEEKMGEQEEKMCEQEEK--MQEQEETMWRQE-EKIREQEKKIREQEEKIREQEEMMQE 700

Query: 1007 RKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
            ++ K+  Q + +  Q +++Q+    +  + +K
Sbjct: 701  QEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEK 732



 Score =  112 bits (279), Expect = 3e-24
 Identities = 101/474 (21%), Positives = 226/474 (47%), Gaps = 33/474 (6%)

Query: 582  APPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKE 641
            A  + L +       +  AQV E +  + L  +QE+    +E+  QE EE+I    ++  
Sbjct: 265  AEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIR 324

Query: 642  QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLRE 701
            +    +RE+ +K   +EE    +EE  R      + +      E+++R ++E   +K  E
Sbjct: 325  EQEEKIREQEEKMRRQEEMMWEKEEKMR------RQEEMMWEKEEKMRRQEEMMWEK--E 376

Query: 702  ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKE 761
            E   +Q+      E+K R++ E++ E+ +  E+ E       K +  +++REQ + + +E
Sbjct: 377  EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEE-------KRQEEEKIREQEKRQEQE 429

Query: 762  AVATLEKEHSAELERLCSSLEAK--HREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH 819
            A    ++E   E E      E K   +E     Q+KI+E ++++E   Q+ + + E ++H
Sbjct: 430  AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQE---QEEMWRQEEKIH 486

Query: 820  QKS--YHVAGYEHELSSLLREKRQEVEGEHE--RRLDKMKEEHQQVMAKAREQYEAEERK 875
            ++   +      HE    +R++ ++V  + E  R  ++   E ++ M +  E+   +E  
Sbjct: 487  EQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEM 546

Query: 876  QRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLR-----RRHREQERKLQDLELD 930
             R E   H   ++   ++  E+E +  RQE+  R ++ +      + REQE K Q+ E  
Sbjct: 547  WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606

Query: 931  LETRAKDVKARLALLEVQEETARREKQQLLD----VQRQVALKSEEATATHQQLEEAQKE 986
            +  + + ++ +   ++ QEE  R +++++ +     Q Q     E+     +Q E+ Q++
Sbjct: 607  MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ 666

Query: 987  HTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040
               + +  +++RE   +++ ++ K+  Q +++Q Q +++ +    +  + +K Q
Sbjct: 667  EETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQ 720



 Score =  103 bits (257), Expect = 1e-21
 Identities = 121/647 (18%), Positives = 279/647 (43%), Gaps = 67/647 (10%)

Query: 609  HLLESKQEKMQQLREKLCQEEEEEI--LRLHQQKEQSLSSLRERLQKAIEEEEARMRE-- 664
            H  E +Q+   Q +E L +E E ++  +R+   ++  L       Q A+++ E   R+  
Sbjct: 105  HSPEDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGEARDLI 164

Query: 665  -----------EESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERAS 713
                       E  Q LS +  Q + + +  E+  +     SL+  R  +  ++  E+ +
Sbjct: 165  SRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNA 224

Query: 714  LEQKNRQMLEQLKEEIEASEKSEQAALNAAK----EKALQQLREQLEGERKEAVATLEKE 769
              Q+  Q++E  K EI+ + K  +  L  AK    ++ LQ   + L  E +   A L+ +
Sbjct: 225  KLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284

Query: 770  HSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
               E   L + L  +  E +   ++KIQE ++K + Q +K   Q E ++ ++   +   E
Sbjct: 285  --VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQ-EEKIREQEEKMRRQE 341

Query: 830  HELSSLLREKRQEVE-----GEHERRLDKMKEEHQQVMAKAREQ-YEAEERKQRAELLGH 883
              +     + R++ E      E  RR ++M  E ++ M +  E  +E EE+ +  E   H
Sbjct: 342  EMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMH 401

Query: 884  LTGELERLQRAHERELETV-------RQEQHKRLEDLRRRHREQERKLQDLELDLETRAK 936
               E E+++   E+  E         RQEQ  ++     + REQE K+++ E  +  + +
Sbjct: 402  ---EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEE 458

Query: 937  DVKARLALLEVQEETARREKQQLLDVQRQVALKSE---EATATHQQLEEAQKEHTHLLQS 993
             +  +    +++EE  R+E++++   + ++  + E   +    H+Q E+ +K+   + + 
Sbjct: 459  KIHEQE---KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ 515

Query: 994  NQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNA 1053
             +++RE  ++++ ++ K+  Q + ++ Q +  +      E E   +Q  + E    +   
Sbjct: 516  EEKIREQEEKIREQEEKMWRQEEKIREQEEMWR------EEEKMHEQEKIWEEEKRQEQE 569

Query: 1054 SPHFEPDLHIEDLRKSLGTNQTK--EVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALR 1111
               +  +  I +  + +   + K  E      + +E ++            +  +   +R
Sbjct: 570  DKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIR 629

Query: 1112 SAKEFLVQQTRSMRRRQTAL-----KAAQQH----------WRHELASAQEVAKDPPGIK 1156
              +E + +Q    + ++  +     K  +Q           WR E    ++  K     +
Sbjct: 630  EQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE 689

Query: 1157 ALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEE 1203
             + +  + ++++   + E +  M +    ++++EEK+ + E  +WE+
Sbjct: 690  KIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736



 Score = 76.3 bits (186), Expect = 2e-13
 Identities = 91/434 (20%), Positives = 195/434 (44%), Gaps = 75/434 (17%)

Query: 448 DKDDSQSSQDEL---QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPE- 503
           +K++    Q+E+   + ++ + LEE++     HE+           EEE  +  E + E 
Sbjct: 374 EKEEKMRRQEEMMWEKEEKIRELEEKM-----HEQEKIREQEEKRQEEEKIREQEKRQEQ 428

Query: 504 ----WKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDP 559
               W++ E++ E        +  + R++         + +E+  + EE+   +E+  + 
Sbjct: 429 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQ 488

Query: 560 EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQ 619
           EE              R  E +   E+     ++  EE V +     Q   +  ++EK++
Sbjct: 489 EE------------IWRQKEKMHEQEE----KIRKQEEKVWR-----QEEKIREQEEKIR 527

Query: 620 QLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQS 679
           +  EK+ ++EE    ++ +Q+E      +   Q+ I EEE R  +E+     W       
Sbjct: 528 EQEEKMWRQEE----KIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKM---W------- 573

Query: 680 STQADEDQIRAEQE---ASLQKLREELESQQKAERA--SLEQKNRQMLEQLKEEIEASEK 734
                E++IR ++E      +K+RE+ E +Q+ E      E+K R+  E+++E+ E   +
Sbjct: 574 ---RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIRE 630

Query: 735 SEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQK 794
            E+      +++ + Q +E+  GE++E +   E++   + E +      +  E +   +K
Sbjct: 631 QEE---KIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMW-----RQEEKIREQEK 682

Query: 795 KIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKM 854
           KI+E ++K   Q ++ + + E ++ ++   +   E        EK QE E +  R+ +KM
Sbjct: 683 KIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQE--------EKMQEQEEKMRRQEEKM 733

Query: 855 KEEHQQVMAKAREQ 868
            E  Q+V  + +E+
Sbjct: 734 WE--QEVRLRQQEE 745



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 40/197 (20%), Positives = 89/197 (45%), Gaps = 43/197 (21%)

Query: 446 IEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWK 505
           I ++++ +  Q+E   KQ + + E+       EE+ +     +  +EE  Q        +
Sbjct: 593 IREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQ--------E 644

Query: 506 EAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAV 565
           + E++GE            Q E+       CE+ ++   Q E +   +E+  + E+K+  
Sbjct: 645 QEEKMGE------------QEEK------MCEQEEKMQEQEETMWRQEEKIREQEKKIR- 685

Query: 566 SPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKL 625
                        E +   E++ +   + M E   ++ EQ+++  ++ ++EKM++  EK+
Sbjct: 686 ----------EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK--MQEQEEKMRRQEEKM 733

Query: 626 CQEEEEEILRLHQQKEQ 642
            ++E    +RL QQ+E+
Sbjct: 734 WEQE----VRLRQQEEK 746


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score =  121 bits (304), Expect = 4e-27
 Identities = 210/956 (21%), Positives = 419/956 (43%), Gaps = 140/956 (14%)

Query: 341  KASEKEAPEDTVDAGEEGSRR--EEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLS 398
            + +E+   E+ ++A     +R  E+   E KK    LE   +   +E   +E+ K   L+
Sbjct: 924  EVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATEN-KVKNLT 982

Query: 399  DSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDE 458
            + +A   ++   L    ++    H   +D L        +  +  + I  K  ++  Q  
Sbjct: 983  EEMAGLDETIAKLSKEKKALQETHQQTLDDL--------QAEEDKVNILTKAKTKLEQQV 1034

Query: 459  LQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASL 518
               + S   E++L   L   +R       LA E       + Q    + +E  E     +
Sbjct: 1035 DDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ----QLDEKLEKKEFEI 1090

Query: 519  SLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRST 578
            S  +S   ++        +K KE  ++ EELG  + EAE      A      +S E+   
Sbjct: 1091 SNLISKIEDEQAVEIQLQKKIKELQARIEELGE-EIEAERASRAKAEKQRSDLSREL--- 1146

Query: 579  EPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQ 638
                  E++SE   +A     AQV    +R   E++ +K+++  E+   + E  +  L +
Sbjct: 1147 ------EEISERLEEAGGATSAQVELNKKR---EAEFQKLRRDLEEATLQHEAMVAALRK 1197

Query: 639  QKEQSLSSLRE------RLQKAIEEEEARMREEESQRLSWLRA----------------- 675
            +   S++ L E      R+++ +E+E++ ++ E     S   A                 
Sbjct: 1198 KHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLED 1257

Query: 676  QVQSSTQADEDQIRAEQEASLQKLREELE----SQQKAERASL-------EQKNRQMLEQ 724
            QV      +E+Q R   + + Q+ R + E    S+Q  E+ +L       +Q + Q +E+
Sbjct: 1258 QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE 1317

Query: 725  LKEEIEASEKSEQAALNAAKEKA--LQQLREQLEGERKEAVATLEKEHSAELERLCSSLE 782
            LK ++E   K++ A  +A +        LREQ E E+         E  AEL+R   +L 
Sbjct: 1318 LKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ---------EGKAELQR---ALS 1365

Query: 783  AKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ- 841
              + EV     K   +A Q+ E +L++   ++  R+ +   HV     + +SL + K++ 
Sbjct: 1366 KANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRL 1424

Query: 842  --EVEG----------------EHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGH 883
              EVE                 + +R  DK+  E +Q   + + + EA +++ R+     
Sbjct: 1425 QNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS----- 1479

Query: 884  LTGELERLQRAHER---ELETVRQEQ---HKRLEDLRRRHREQERKLQDLELDLETRAKD 937
            L+ EL +++  +E    +LET+R+E     + + DL  +  E  +++ +LE  ++ + + 
Sbjct: 1480 LSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELE-KIKKQVEQ 1538

Query: 938  VKARL-ALLEVQEETARREKQQLLDVQRQV-ALKSE---EATATHQQLEEAQKEHTHLLQ 992
             K  + A LE  E +   E+ ++L +Q ++  +KSE   +     +++++ ++ HT +++
Sbjct: 1539 EKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVE 1598

Query: 993  SNQQL--REILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKK----QHLLREV 1046
            + Q     EI     A ++K + + DL + + Q    H + L AE+ +     Q +L+E 
Sbjct: 1599 TMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQL--NHANRLAAESLRNYRNTQGILKET 1656

Query: 1047 TVEENNA---SPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYL---DSLSSHNVW 1100
             +  ++A       +  L I + R +L   + +E+ ++L Q++    +   + L +    
Sbjct: 1657 QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERV 1716

Query: 1101 HLLSAEGVALRSAKEFL---VQQTRS-----MRRRQTALKAAQQHWRHELASAQEVAKDP 1152
             LL  +  +L + K+ L   V Q +S     ++  + A + A++        A+E+ K+ 
Sbjct: 1717 QLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQ 1776

Query: 1153 PGIKALEDMRKNLE---KETRH-LDEMKS-AMRKGHNLLKKKEEKLNQLESSLWEE 1203
                 LE M+KNLE   K+ +H LDE +  A++ G   ++K E ++ +LE  +  E
Sbjct: 1777 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENE 1832



 Score =  100 bits (249), Expect = 1e-20
 Identities = 112/534 (20%), Positives = 245/534 (45%), Gaps = 53/534 (9%)

Query: 683  ADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNA 742
            A+ ++  A  +   QK ++EL ++ +A+R  LE+K   +L++ K +++   +SE  +L  
Sbjct: 846  AETEKEMATMKEEFQKTKDEL-AKSEAKRKELEEKMVTLLKE-KNDLQLQVQSEADSLAD 903

Query: 743  AKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQK 802
            A+E+  Q ++ +++ E K    T   E   E+    ++ + K  +  S L+K I +  + 
Sbjct: 904  AEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDL-EL 962

Query: 803  EEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQV- 861
              A+++K     E++V   +  +AG +  ++ L +EK+  ++  H++ LD ++ E  +V 
Sbjct: 963  TLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKK-ALQETHQQTLDDLQAEEDKVN 1021

Query: 862  -MAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ 920
             + KA+ + E +        +  L G LE+ ++    +LE  +++    L+  +    + 
Sbjct: 1022 ILTKAKTKLEQQ--------VDDLEGSLEQ-EKKLRMDLERAKRKLEGDLKLAQESTMDM 1072

Query: 921  ERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQL 980
            E   Q L+  LE +  ++   ++ +E ++    + ++++ ++Q ++    EE  A     
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASR 1132

Query: 981  EEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ 1040
             +A+K+ + L   +++L EI + L+       +QV+L + +  + QK    LE      Q
Sbjct: 1133 AKAEKQRSDL---SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT--LQ 1187

Query: 1041 HLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVW 1100
            H      + + +A    E    I++L++         V   L + K +L +++       
Sbjct: 1188 HEAMVAALRKKHADSMAELGEQIDNLQR---------VKQKLEKEKSELKMETDD----- 1233

Query: 1101 HLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALED 1160
              LS+   A+  AK  L +  RS+  + + LK  ++         Q +  D      L  
Sbjct: 1234 --LSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEE-------EQQRLIND------LTA 1278

Query: 1161 MRKNLEKE----TRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTL 1210
             R  L+ E    +R LDE  + + +     +   +++ +L+  L EE   +  L
Sbjct: 1279 QRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNAL 1332



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 173/794 (21%), Positives = 347/794 (43%), Gaps = 111/794 (13%)

Query: 449  KDDSQSSQDELQSKQSKG--LEERLSPPLPHEE----RAQSPPRSLATEEEPPQGP---- 498
            K++ Q ++DEL   ++K   LEE++   L  +     + QS   SLA  EE  +      
Sbjct: 856  KEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNK 915

Query: 499  -EGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKG------------KEQHSQ 545
             + + + KE  E  E+    ++ +L+ ++ +     +  +K             KE+H+ 
Sbjct: 916  IQLEAKIKEVTERAEEEE-EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 974

Query: 546  AEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAV-----A 600
              ++    EE    +E +A      +S E ++ +      Q +   L+A E+ V     A
Sbjct: 975  ENKVKNLTEEMAGLDETIA-----KLSKEKKALQET---HQQTLDDLQAEEDKVNILTKA 1026

Query: 601  QVLEQDQRHLLESKQEKMQQLREKL--CQEEEEEILRLHQQKEQSLSSLRERLQKAIEEE 658
            +   + Q   LE   E+ ++LR  L   + + E  L+L Q+    + + +++L + +E++
Sbjct: 1027 KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKK 1086

Query: 659  EARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKN 718
            E          +S L ++++   QA E Q++ + +  LQ   EEL  + +AERAS  +  
Sbjct: 1087 EFE--------ISNLISKIEDE-QAVEIQLQKKIK-ELQARIEELGEEIEAERASRAKAE 1136

Query: 719  RQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLC 778
            +Q  +  +E  E SE+ E+A                  G    A   L K+  AE ++L 
Sbjct: 1137 KQRSDLSRELEEISERLEEA------------------GGATSAQVELNKKREAEFQKLR 1178

Query: 779  SSLE---AKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL 835
              LE    +H  +V++L+KK  ++  +   Q+   L +V+ ++ ++   +     +LSS 
Sbjct: 1179 RDLEEATLQHEAMVAALRKKHADSMAELGEQIDN-LQRVKQKLEKEKSELKMETDDLSS- 1236

Query: 836  LREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAH 895
              E   + +G  E+    ++++  ++  K       EE +QR  L+  LT +  RLQ   
Sbjct: 1237 NAEAISKAKGNLEKMCRSLEDQVSELKTK-------EEEQQR--LINDLTAQRARLQ-TE 1286

Query: 896  ERELETVRQEQHKRLEDLRRRHREQERKLQDL--ELDLETRAKDVKARLALLEVQEETAR 953
              E      E+   +  L R  +   +++++L  +L+ ET+AK+  A  AL   + +   
Sbjct: 1287 AGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAH-ALQSSRHDCDL 1345

Query: 954  REKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLES 1013
              +Q   + + +  L+   + A  +  +   K  T  +Q  ++L E   +L  R  + E 
Sbjct: 1346 LREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEE 1405

Query: 1014 QVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTN 1073
             V+ + A+   L+K    L+ E +        + VE +NA+           L K     
Sbjct: 1406 HVEAVNAKCASLEKTKQRLQNEVEDLM-----LDVERSNAA--------CAALDKK--QR 1450

Query: 1074 QTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKA 1133
               +V S   Q  E+   +  +S      LS E   +++  E  + Q  ++RR    L  
Sbjct: 1451 NFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNL-- 1508

Query: 1134 AQQHWRHELAS-AQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEK 1192
                 + E++   +++A+    I  LE ++K +E+E     E+++A+ +    L+ +E K
Sbjct: 1509 -----QQEISDLTEQIAEGGKQIHELEKIKKQVEQEK---CEIQAALEEAEASLEHEEGK 1560

Query: 1193 LNQLESSLWEEASD 1206
            + +++  L +  S+
Sbjct: 1561 ILRIQLELNQVKSE 1574



 Score = 90.9 bits (224), Expect = 8e-18
 Identities = 194/946 (20%), Positives = 390/946 (41%), Gaps = 156/946 (16%)

Query: 216  EETNEE--DEEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDS 273
            +ET+++  D+ +++   V+  ++    L   +  L G  E E+ LR      K+ +  D 
Sbjct: 1003 QETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL 1062

Query: 274  DAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKAD 333
              A             +S++     K +        L EK E ++ E     NL++   D
Sbjct: 1063 KLA------------QESTMDMENDKQQ--------LDEKLEKKEFE---ISNLISKIED 1099

Query: 334  PTGSE-PAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQELE-ISEH 391
                E   +   KE      + GEE     EA +  + KA   E+  SD S+ELE ISE 
Sbjct: 1100 EQAVEIQLQKKIKELQARIEELGEE----IEAERASRAKA---EKQRSDLSRELEEISER 1152

Query: 392  MKEPQLSDSIASDPKSFHGLDFG-FRSRISEHLLDVDVLSPVLGGACRQAQQPLGIE--- 447
            ++E   + S   +       +F   R  + E  L  + +   L      +   LG +   
Sbjct: 1153 LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDN 1212

Query: 448  ----------DKDDSQSSQDELQS-------------KQSKGLEERLSPPLPHEERAQSP 484
                      +K + +   D+L S             K  + LE+++S     EE  Q  
Sbjct: 1213 LQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRL 1272

Query: 485  PRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQR---------EQAPSPPAA 535
               L  +    Q   G+   +  E+    S  S S Q S Q+         E+  +  A 
Sbjct: 1273 INDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNAL 1332

Query: 536  CEKGKEQHSQAEELGPGQEEAEDPEEKV--AVSPTPPVSPEVRS---TEPVAPPEQLSEA 590
                +      + L    EE ++ + ++  A+S       + R+   T+ +   E+L EA
Sbjct: 1333 AHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEA 1392

Query: 591  ALKAMEEAVAQVLEQDQRHL--LESKQEKMQQLREKLCQEEEEEILRLHQ---------Q 639
              K     +AQ L++ + H+  + +K   +++ +++L  E E+ +L + +         +
Sbjct: 1393 KKK-----LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDK 1447

Query: 640  KEQSLSSLRERLQKAIEEEEARMR--EEESQRLSWLRAQVQSSTQADEDQIRA--EQEAS 695
            K+++   +    ++  EE +A +   ++ES+ LS    +V++  +   DQ+     +  +
Sbjct: 1448 KQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKN 1507

Query: 696  LQKLREELESQ--QKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ---- 749
            LQ+   +L  Q  +  ++    +K ++ +EQ K EI+A+ +  +A+L   + K L+    
Sbjct: 1508 LQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE 1567

Query: 750  --QLREQLE---GERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEE 804
              Q++ +++    E+ E +  L++ H+  +E + S+L+A+ R    +L+ K     +K E
Sbjct: 1568 LNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVK-----KKME 1622

Query: 805  AQLQKCLGQVEHRVHQKSYHVAGYEH----------ELSSLLR--EKRQEVEGEHERRLD 852
              L +   Q+ H     +  +  Y +           L   LR  E  +E     ERR +
Sbjct: 1623 GDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRAN 1682

Query: 853  KMKEEHQQVMAKARE--------QYEAEERKQRAELLGHLTGELERLQRAHERELETVRQ 904
             ++ E +++ A   +        + E  +  +R +LL      L   ++  E ++  ++ 
Sbjct: 1683 LLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQS 1742

Query: 905  EQHKRLEDLRRRHREQERKLQDLELDLETRAK--DVKARLALLEVQEETARREKQQLLDV 962
            E  + +++ R    + ++ + D  +  E   K  D  A L  ++   E   ++ Q  LD 
Sbjct: 1743 EVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE 1802

Query: 963  QRQVALKS-----EEATATHQQLE-EAQKEHTH-------LLQSNQQLREIL---DELQA 1006
              Q+ALK      ++  A  ++LE E + E          L +  ++++E+    +E + 
Sbjct: 1803 AEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRK 1862

Query: 1007 RKLKLESQVDLLQAQSQQLQKHFSSLEAEA-------QKKQHLLRE 1045
              L+L+  VD LQA+ +  ++     E ++       +K QH L E
Sbjct: 1863 NVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEE 1908



 Score = 89.0 bits (219), Expect = 3e-17
 Identities = 134/681 (19%), Positives = 286/681 (41%), Gaps = 96/681 (14%)

Query: 617  KMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQ 676
            K++ L +    E+E   ++   QK +   +  E  +K +EE+   + +E++     ++++
Sbjct: 838  KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSE 897

Query: 677  VQSSTQADE--DQI---RAEQEASLQKLREELESQQK--AERASLEQKNRQMLEQLKEEI 729
              S   A+E  +Q+   + + EA ++++ E  E +++  AE  + ++K      +LK++I
Sbjct: 898  ADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDI 957

Query: 730  EASE--KSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHRE 787
            +  E   ++      A E  ++ L E++ G   E +A L KE  A        L+  H++
Sbjct: 958  DDLELTLAKVEKEKHATENKVKNLTEEMAG-LDETIAKLSKEKKA--------LQETHQQ 1008

Query: 788  VVSSLQKK------IQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ 841
             +  LQ +      + +A+ K E Q+    G +E             E +L   L   ++
Sbjct: 1009 TLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ------------EKKLRMDLERAKR 1056

Query: 842  EVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELET 901
            ++EG+      K+ +E    M   ++Q + +  K+  E + +L  ++E  ++A E +L+ 
Sbjct: 1057 KLEGDL-----KLAQESTMDMENDKQQLDEKLEKKEFE-ISNLISKIED-EQAVEIQLQK 1109

Query: 902  VRQEQHKRLEDL-------RRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARR 954
              +E   R+E+L       R    + E++  DL  +LE  ++ ++        Q E  ++
Sbjct: 1110 KIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKK 1169

Query: 955  EKQQLLDVQRQVALKSEEATATHQQLEEA-QKEHTHLLQSNQQLREILDELQARKLKLES 1013
             + +   ++R +    EEAT  H+ +  A +K+H     S  +L E +D LQ  K KLE 
Sbjct: 1170 REAEFQKLRRDL----EEATLQHEAMVAALRKKHA---DSMAELGEQIDNLQRVKQKLEK 1222

Query: 1014 QVDLLQAQS---------------------QQLQKHFSSLEAEAQKKQHLLREVTVEE-- 1050
            +   L+ ++                     + L+   S L+ + +++Q L+ ++T +   
Sbjct: 1223 EKSELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRAR 1282

Query: 1051 -NNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVA 1109
                +  +   L  +D   S  +   +  +  + + K  L  ++ + + + H L +    
Sbjct: 1283 LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHD 1342

Query: 1110 LRSAKEFLVQQTRSMRRRQTAL-----KAAQQHWRHELASAQEVAKDPPGIKALEDMRKN 1164
                +E   ++       Q AL     + AQ   ++E  + Q         + LE+ +K 
Sbjct: 1343 CDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT-------EELEEAKKK 1395

Query: 1165 LEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFD-- 1222
            L +  +  +E   A+      L+K +++L      L  +         +  KK   FD  
Sbjct: 1396 LAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKV 1455

Query: 1223 LSDMDSLSSESSESFSPPHRE 1243
            LS+      E+        +E
Sbjct: 1456 LSEWKQKYEETQAELEASQKE 1476



 Score = 83.2 bits (204), Expect = 2e-15
 Identities = 169/776 (21%), Positives = 324/776 (41%), Gaps = 113/776 (14%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKK 371
            +K E EKSE K+       + D   S     S+ +   + +    E    E   KE +++
Sbjct: 1218 QKLEKEKSELKM-------ETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQ 1270

Query: 372  ASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSP 431
                +  +  A  + E  E+ ++    D++ S               +   L +      
Sbjct: 1271 RLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKN 1330

Query: 432  VLGGACRQAQQPLGI--EDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLA 489
             L  A + ++    +  E  ++ Q  + ELQ   SK   E       +E  A      L 
Sbjct: 1331 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL- 1389

Query: 490  TEEEPPQGPEGQPEWKEAEELGEDSAASLS------------LQLSLQREQAPSPPAACE 537
             EE   +  +   E +E  E      ASL             L L ++R  A    A   
Sbjct: 1390 -EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNA----ACAA 1444

Query: 538  KGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEE 597
              K+Q +  + L   +++ E+ + ++  S     S    STE +   + + E +L  +E 
Sbjct: 1445 LDKKQRNFDKVLSEWKQKYEETQAELEASQKESRS---LSTE-LFKVKNVYEESLDQLE- 1499

Query: 598  AVAQVLEQDQRHLLESKQEKMQQLREKLCQ--EEEEEILRLHQQKEQSLSSLRERLQKAI 655
                 L ++ ++L    Q+++  L E++ +  ++  E+ ++ +Q EQ     +  +Q A+
Sbjct: 1500 ----TLRRENKNL----QQEISDLTEQIAEGGKQIHELEKIKKQVEQE----KCEIQAAL 1547

Query: 656  EEEEARMREEESQRLSWLRAQVQ-SSTQADEDQIRAEQEASLQKLREE----LESQQKAE 710
            EE EA +  EE + L   R Q++ +  +++ D+  AE++  + +L+      +E+ Q   
Sbjct: 1548 EEAEASLEHEEGKIL---RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTL 1604

Query: 711  RASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLRE--QLEGERKEAVATLE- 767
             A +  +N  +  ++K+++E      +  LN A   A + LR     +G  KE    L+ 
Sbjct: 1605 DAEIRSRNDAL--RVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDD 1662

Query: 768  --------KEHSAELERLCSSLEAKHREVVSSLQ-----KKIQEAQQKEEAQLQKCLGQV 814
                    KE  A +ER  + L+A+  E+ ++L+     +KI E +  + ++  + L   
Sbjct: 1663 ALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ 1722

Query: 815  EHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERR----------LDKMKEE-----HQ 859
               +      +     +L S + E  QE     E+            +++K+E     H 
Sbjct: 1723 NTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1782

Query: 860  QVMAKAREQY--EAEERKQRAELLGHLTGELERLQR--AHERELETVRQEQHKRLEDLRR 915
            + M K  EQ   + + R   AE L  L G  +++Q+  A  RELE   + + KR  +  +
Sbjct: 1783 ERMKKNLEQTVKDLQHRLDEAEQLA-LKGGKKQIQKLEARVRELEGEVENEQKRNAEAVK 1841

Query: 916  RHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATA 975
              R+ ER++++L    E   K+V  RL              Q L+D + Q  +KS +   
Sbjct: 1842 GLRKHERRVKELTYQTEEDRKNV-LRL--------------QDLVD-KLQAKVKSYK--- 1882

Query: 976  THQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSS 1031
              +Q EEA+++    L   ++L+  L+E + R    ESQV+ L+ +S+++    S+
Sbjct: 1883 --RQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKISA 1936



 Score = 66.6 bits (161), Expect = 2e-10
 Identities = 153/768 (19%), Positives = 309/768 (40%), Gaps = 110/768 (14%)

Query: 206  KTALSLLGLGEETN-----------EEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFEY 254
            K A S+  LGE+ +           E+ E + +   + S++E +     ++  +    E 
Sbjct: 1198 KHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSLED 1257

Query: 255  EES-LRTSQPEEKKDVS-LDSDAAGPPTPCKPSSPGADS--SLSSAVGKGRQGSGARPG- 309
            + S L+T + E+++ ++ L +  A   T     S   D   +L S + + +Q S  +   
Sbjct: 1258 QVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEE 1317

Query: 310  -LPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDA-----GEEGSRREE 363
               + EE  K++  +   L + + D          E+E   +   A      E    R +
Sbjct: 1318 LKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK 1377

Query: 364  AAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHL 423
               +  ++   LEE     +Q L+ +E   E  ++   AS  K+   L    ++ + + +
Sbjct: 1378 YETDAIQRTEELEEAKKKLAQRLQEAEEHVEA-VNAKCASLEKTKQRL----QNEVEDLM 1432

Query: 424  LDVDVLSPVLGGACRQAQQ--PLGIEDKDDSQSSQDELQS--KQSKGLEERL-------S 472
            LDV+  +       ++ +    +  E K   + +Q EL++  K+S+ L   L        
Sbjct: 1433 LDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYE 1492

Query: 473  PPLPHEERAQSPPRSLATE--EEPPQGPEGQPEWKEAEELG--------EDSAASLSLQL 522
              L   E  +   ++L  E  +   Q  EG  +  E E++         E  AA    + 
Sbjct: 1493 ESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEA 1552

Query: 523  SLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEE---KVAVSPTPPVSPEVRSTE 579
            SL+ E+        E  + +     ++    EE +  +    +V  +    +  E+RS  
Sbjct: 1553 SLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN 1612

Query: 580  PVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEE---EEILRL 636
                 ++  E  L  ME      ++ +  + L ++  +  +  + + +E +   ++ LR 
Sbjct: 1613 DALRVKKKMEGDLNEME------IQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRG 1666

Query: 637  HQQKEQSLSSLRER---LQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQE 693
             +  ++ L+ +  R   LQ  IEE  A + + E  R     A+ +    ++  Q+   Q 
Sbjct: 1667 QEDLKEQLAIVERRANLLQAEIEELWATLEQTERSRKI---AEQELLDASERVQLLHTQN 1723

Query: 694  ASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLRE 753
             SL   +++LE+        + Q   ++ E ++E   A EK+++A  +AA       + E
Sbjct: 1724 TSLINTKKKLEND-------VSQLQSEVEEVIQESRNAEEKAKKAITDAA------MMAE 1770

Query: 754  QLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQ 813
            +L+ E+         + SA LER+  +LE    + V  LQ ++ EA+Q      +K + +
Sbjct: 1771 ELKKEQ---------DTSAHLERMKKNLE----QTVKDLQHRLDEAEQLALKGGKKQIQK 1817

Query: 814  VEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEE 873
            +E RV                  RE   EVE E +R  + +K   +         Y+ EE
Sbjct: 1818 LEARV------------------RELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEE 1859

Query: 874  RKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQE 921
             ++    L  L  +L+   ++++R+ E   ++ +  L   R+   E E
Sbjct: 1860 DRKNVLRLQDLVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELE 1907


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score =  121 bits (303), Expect = 6e-27
 Identities = 214/925 (23%), Positives = 402/925 (43%), Gaps = 127/925 (13%)

Query: 344  EKEAPEDTV-DAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIA 402
            EK A E+ V +  EE +  +E   +  K+  AL+E    A  +L+  E  K   L+ +  
Sbjct: 967  EKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED-KVNTLTKAKV 1025

Query: 403  SDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSK 462
               +    L+ G   +  +  +D++     L G  +  Q+ + ++ ++D Q   + L+ K
Sbjct: 1026 KLEQQVDDLE-GSLEQEKKVRMDLERAKRKLEGDLKLTQESI-MDLENDKQQLDERLKKK 1083

Query: 463  --QSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSL 520
              +   L  R+                   E+E   G + Q + KE +   E+       
Sbjct: 1084 DFELNALNARI-------------------EDEQALGSQLQKKLKELQARIEE------- 1117

Query: 521  QLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEP 580
               L+ E      A  +  K +   + EL   +E +E  EE    +       + R  E 
Sbjct: 1118 ---LEEELEAERTARAKVEKLRSDLSREL---EEISERLEEAGGATSVQIEMNKKREAEF 1171

Query: 581  VAPPEQLSEAALKAMEEAVAQVLEQ---DQRHLLESKQEKMQQLREKLCQEEEEEILRLH 637
                  L EA L+   EA A  L +   D    L  + + +Q++++KL +E+ E  L L 
Sbjct: 1172 QKMRRDLEEATLQ--HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEL- 1228

Query: 638  QQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQ 697
                  ++S  E++ KA    E   R  E Q ++  R++ + + ++  D     Q A LQ
Sbjct: 1229 ----DDVTSNMEQIIKAKANLEKMCRTLEDQ-MNEHRSKAEETQRSVNDL--TSQRAKLQ 1281

Query: 698  KLREELESQQKAERASLEQKNR------QMLEQLKEEIEASEKSEQA---ALNAAKEKAL 748
                EL  Q   + A + Q  R      Q LE LK ++E   K++ A   AL +A+    
Sbjct: 1282 TENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDC- 1340

Query: 749  QQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQ 808
              LREQ E E  EA A L++  S     + +    K+        ++++EA++K   +LQ
Sbjct: 1341 DLLREQYE-EETEAKAELQRVLSKANSEV-AQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1398

Query: 809  KCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERR--LDKMKEEHQQVMAKAR 866
            +    VE  V+ K   +   +H L + + +   +VE  +     LDK +    +++A+ +
Sbjct: 1399 EAEEAVE-AVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1457

Query: 867  EQYEAE--ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKL 924
            ++YE    E +   +    L+ EL +L+ A+E  LE         LE  +R ++  + ++
Sbjct: 1458 QKYEESQSELESSQKEARSLSTELFKLKNAYEESLE--------HLETFKRENKNLQEEI 1509

Query: 925  QDLELDLETRAKDV----KARLAL----------LEVQEETARREKQQLLDVQ---RQVA 967
             DL   L +  K +    K R  L          LE  E +   E+ ++L  Q    Q+ 
Sbjct: 1510 SDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIK 1569

Query: 968  LKSEEATATH-QQLEEAQKEHTHLLQSNQQL--REILDELQARKLKLESQVDLLQAQSQQ 1024
             + E   A   +++E+A++ H  ++ S Q     E     +A ++K + + DL + + Q 
Sbjct: 1570 AEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQL 1629

Query: 1025 LQKHFSSLEAEAQKK----QHLLREVTVEENNA---SPHFEPDLHIEDLRKSLGTNQTKE 1077
               H + + AEAQK+    Q LL++  ++ ++A   +   + ++ I + R +L   + +E
Sbjct: 1630 --SHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1687

Query: 1078 VSSSLSQSKEDLYL---DSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAA 1134
            + + + Q++    L   + + +     LL ++  +L + K+   +    + + QT ++ A
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK---KMDADLSQLQTEVEEA 1744

Query: 1135 QQHWRHE-----------LASAQEVAKDPPGIKALEDMRKNLE---KETRH-LDEMKS-A 1178
             Q  R+               A+E+ K+      LE M+KN+E   K+ +H LDE +  A
Sbjct: 1745 VQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIA 1804

Query: 1179 MRKGHNLLKKKEEKLNQLESSLWEE 1203
            ++ G   L+K E ++ +LE+ L  E
Sbjct: 1805 LKGGKKQLQKLEARVRELENELEAE 1829



 Score = 95.1 bits (235), Expect = 4e-19
 Identities = 140/656 (21%), Positives = 274/656 (41%), Gaps = 77/656 (11%)

Query: 639  QKEQSLSSLRE---RLQKAIEEEEARMREEESQRLSWLRAQ--VQSSTQADEDQIRAEQE 693
            ++E+ ++S++E   RL++A+E+ EAR +E E + +S L+ +  +Q   QA++D +   +E
Sbjct: 844  EREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEE 903

Query: 694  ASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLRE 753
               Q ++ +++         LE K ++M E+L++E E +  +E  A     E    +L+ 
Sbjct: 904  RCDQLIKNKIQ---------LEAKVKEMNERLEDEEEMN--AELTAKKRKLEDECSELKR 952

Query: 754  QLEGERKEAVATLEKEHSAELERLCSSLE--AKHREVVSSL---QKKIQEAQQKEEAQLQ 808
             ++ + +  +A +EKE  A   ++ +  E  A   E+++ L   +K +QEA Q+    LQ
Sbjct: 953  DID-DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQ 1011

Query: 809  KCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRL--DKMKEEHQQVMAKAR 866
                +V      K       +    SL +EK+  ++ E  +R     +K   + +M    
Sbjct: 1012 AEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEN 1071

Query: 867  EQYEAEERKQRAEL-LGHLTGELERLQRAHERELETVRQEQHKRLEDLRRR---HREQER 922
            ++ + +ER ++ +  L  L   +E  ++A   +L+   +E   R+E+L       R    
Sbjct: 1072 DKQQLDERLKKKDFELNALNARIED-EQALGSQLQKKLKELQARIEELEEELEAERTARA 1130

Query: 923  KLQDLELDLETRAKDVKARL----ALLEVQEETARREKQQLLDVQRQVALKSEEATATHQ 978
            K++ L  DL    +++  RL        VQ E  ++ + +   ++R +    EEAT  H+
Sbjct: 1131 KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL----EEATLQHE 1186

Query: 979  QLEEA-QKEHTHLLQSNQQLREILDELQARKLKLES-------QVDLLQAQSQQLQKHFS 1030
                A +K+H     S  +L E +D LQ  K KLE        ++D + +  +Q+ K  +
Sbjct: 1187 ATAAALRKKHA---DSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKA 1243

Query: 1031 SLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLY 1090
            +LE   +  +  + E      + S   E    + DL       QT+    S    +++  
Sbjct: 1244 NLEKMCRTLEDQMNE------HRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEAL 1297

Query: 1091 LDSLSSHNVWHLLSAEGVALR-----SAKEFLVQQTRSMRRRQTALKAAQQHWRHELASA 1145
            +  L+   + +    E +  +      AK  L    +S R     L+   +      A  
Sbjct: 1298 ISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAEL 1357

Query: 1146 QEVAKDPPG----------------IKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKK 1189
            Q V                       + LE+ +K L +  +  +E   A+    + L+K 
Sbjct: 1358 QRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKT 1417

Query: 1190 EEKLNQLESSLWEEASDEGTLGGSPTKKAVTFD--LSDMDSLSSESSESFSPPHRE 1243
            + +L      L  +         +  KK   FD  L++      ES        +E
Sbjct: 1418 KHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKE 1473



 Score = 91.7 bits (226), Expect = 5e-18
 Identities = 184/772 (23%), Positives = 338/772 (43%), Gaps = 117/772 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPAKASEK-EAPEDTVDAGEEGSRREEAAKEPKK 370
            +K E EKSE K+  + VT   +      A   +     ED ++  E  S+ EE  +    
Sbjct: 1215 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN--EHRSKAEETQRSVND 1272

Query: 371  KASA---LEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVD 427
              S    L+  + + S++L+  E +   QL+    +  +    L    + ++ E +   +
Sbjct: 1273 LTSQRAKLQTENGELSRQLDEKEALIS-QLTRGKLTYTQQLEDL----KRQLEEEVKAKN 1327

Query: 428  VLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRS 487
             L+  L  A       L  E  ++   ++ ELQ   SK   E       +E  A      
Sbjct: 1328 ALAHALQSARHDCD--LLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEE 1385

Query: 488  LATEEEPPQGPEGQPEWKEAEELGEDSAASLS------------LQLSLQREQAPSPPAA 535
            L  EE   +  +   E +EA E      +SL             L + ++R  A    AA
Sbjct: 1386 L--EEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA----AA 1439

Query: 536  CEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAM 595
                K+Q +  + L   +++ E+ + ++  S       E RS         LS    K +
Sbjct: 1440 AALDKKQRNFDKILAEWKQKYEESQSELESS-----QKEARS---------LSTELFK-L 1484

Query: 596  EEAVAQVLEQDQRHLLESK--QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQK 653
            + A  + LE  +    E+K  QE++  L E+L     + I  L + ++Q L + +  LQ 
Sbjct: 1485 KNAYEESLEHLETFKRENKNLQEEISDLTEQL-GSSGKTIHELEKVRKQ-LEAEKMELQS 1542

Query: 654  AIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAE--- 710
            A+EE EA +  EE + L   RAQ++ +      QI+AE E  L +  EE+E  ++     
Sbjct: 1543 ALEEAEASLEHEEGKIL---RAQLEFN------QIKAEIERKLAEKDEEMEQAKRNHLRV 1593

Query: 711  ----RASLEQKNRQMLEQLKE-----------EIEASEKSEQAALNAAKEKALQQLREQL 755
                + SL+ + R   E L+            EI+ S  +  AA    + K+LQ L +  
Sbjct: 1594 VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDT 1653

Query: 756  EGERKEAVATLE--KEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQ 813
            + +  +AV   +  KE+ A +ER  + L+A+  E+  ++ ++ + +++  E +L +   +
Sbjct: 1654 QIQLDDAVRANDDLKENIAIVERRNNLLQAELEEL-RAVVEQTERSRKLAEQELIETSER 1712

Query: 814  VEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEE 873
            V+  +H ++  +   + ++ + L + + EVE E  +     +E+ ++ +  A     AEE
Sbjct: 1713 VQ-LLHSQNTSLINQKKKMDADLSQLQTEVE-EAVQECRNAEEKAKKAITDAAMM--AEE 1768

Query: 874  RKQRAELLGHLTGELERLQRAHERELETVRQEQH--------------KRLEDLRRRHRE 919
             K+  +   HL    ER+++  E   +T++  QH              K+L+ L  R RE
Sbjct: 1769 LKKEQDTSAHL----ERMKKNME---QTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRE 1821

Query: 920  QERKLQDLELDLETRAKDVKA------RLALLEVQEETARREKQQLLDVQRQVALKSEEA 973
             E    +LE + +  A+ VK       R+  L  Q E  R+   +L D+  ++ LK +  
Sbjct: 1822 LEN---ELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQLKVK-- 1876

Query: 974  TATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQL 1025
             A  +Q EEA+++    L   ++++  LDE + R    ESQV+ L+A+S+ +
Sbjct: 1877 -AYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1927



 Score = 87.8 bits (216), Expect = 7e-17
 Identities = 190/954 (19%), Positives = 384/954 (40%), Gaps = 142/954 (14%)

Query: 221  EDEEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPT 280
            E E+ +    V + +E +  L   I  L  +   +++L+ +  +   D+  + D     T
Sbjct: 965  EKEKHATENKVKNLTEEMAGLDEIIAKLTKE---KKALQEAHQQALDDLQAEEDKVNTLT 1021

Query: 281  PCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPA 340
              K      +  +    G   Q    R  L   +   + + K+ +  +    +       
Sbjct: 1022 KAKVK---LEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDE 1078

Query: 341  KASEKEAPEDTVDAGEE-----GSRREEAAKEPKKKASALEEG--------------SSD 381
            +  +K+   + ++A  E     GS+ ++  KE + +   LEE                SD
Sbjct: 1079 RLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSD 1138

Query: 382  ASQELE-ISEHMKEPQLSDSIASDPKSFHGLDFG-FRSRISEHLLDVDVLSPVLGGACRQ 439
             S+ELE ISE ++E   + S+  +       +F   R  + E  L  +  +  L      
Sbjct: 1139 LSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHAD 1198

Query: 440  AQQPLGIEDKDDSQSSQDELQSKQSK-GLE-ERLSPPLPHEERAQSPPRSLATEEEPPQG 497
            +   LG E  D+ Q  + +L+ ++S+  LE + ++  +    +A++    +    E    
Sbjct: 1199 SVAELG-EQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMN 1257

Query: 498  PEGQPEWKEAEELGEDSAASLSLQ-----LSLQREQAPSPPAACEKGKEQHSQAEELGPG 552
                   +    + + ++    LQ     LS Q ++  +  +   +GK  ++Q  E    
Sbjct: 1258 EHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKR 1317

Query: 553  QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAAL-KAMEEAVAQVLEQDQRHLL 611
            Q E E   +            +          E  ++A L + + +A ++V +   ++  
Sbjct: 1318 QLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYET 1377

Query: 612  ESKQ--EKMQQLREKLCQ--EEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
            ++ Q  E++++ ++KL Q  +E EE +     K  SL   + RLQ  IE+    +    +
Sbjct: 1378 DAIQRTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNA 1437

Query: 668  QRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERA---------SLEQKN 718
                   A      Q + D+I AE +   ++ + ELES QK  R+         +  +++
Sbjct: 1438 A------AAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEES 1491

Query: 719  RQMLEQLKEEI-----EASEKSEQAALNAAKEKALQQLREQLEGER-------KEAVATL 766
             + LE  K E      E S+ +EQ   +      L+++R+QLE E+       +EA A+L
Sbjct: 1492 LEHLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASL 1551

Query: 767  EKEHS-------------AELERLCSSLEAK-------HREVVSSLQKKIQ-EAQQKEEA 805
            E E               AE+ER  +  + +       H  VV SLQ  +  E + + EA
Sbjct: 1552 EHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611

Query: 806  -----QLQKCLGQVEHRVHQKSYHVAGYEHE---LSSLLREKRQEVEGEH---------- 847
                 +++  L ++E ++   +   A  + +   L SLL++ + +++             
Sbjct: 1612 LRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENI 1671

Query: 848  ---ERRLDKMKEEHQQVMA------KAREQYEAE--ERKQRAELLGHLTGELERLQRAHE 896
               ERR + ++ E +++ A      ++R+  E E  E  +R +LL      L   ++  +
Sbjct: 1672 AIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMD 1731

Query: 897  RELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAK--DVKARLALLEVQEETARR 954
             +L  ++ E  + +++ R    + ++ + D  +  E   K  D  A L  ++   E   +
Sbjct: 1732 ADLSQLQTEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIK 1791

Query: 955  EKQQLLDVQRQVALKSEE---------ATATHQQLEEAQKEHTH----LLQSNQQLREIL 1001
            + Q  LD   Q+ALK  +               +LE  QK +      + +S ++++E+ 
Sbjct: 1792 DLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELT 1851

Query: 1002 ---DELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEA-------QKKQHLLRE 1045
               +E +   L+L+  VD LQ + +  ++     E +A       +K QH L E
Sbjct: 1852 YQTEEDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDE 1905



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 98/471 (20%), Positives = 201/471 (42%), Gaps = 50/471 (10%)

Query: 766  LEKEHSAELERLCSSLEAKHREVVSSLQ-KKIQEAQQKEEAQLQKCLGQVEHRVHQKSYH 824
            LE+     L R+ + ++A+ R V++ ++ KK+ E +      L      +   +  K++ 
Sbjct: 773  LEEMRDERLSRIITRIQAQSRGVLARMEYKKLLERRDS----LLVIQWNIRAFMGVKNWP 828

Query: 825  VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERK--------- 875
                  ++  LL+        E E+ +  MKEE  + + +A E+ EA  ++         
Sbjct: 829  WMKLYFKIKPLLKS------AEREKEMASMKEEFTR-LKEALEKSEARRKELEEKMVSLL 881

Query: 876  -QRAELLGHLTGELERLQRAHER---------ELETVRQEQHKRLEDLRRRHRE---QER 922
             ++ +L   +  E + L  A ER         +LE   +E ++RLED    + E   ++R
Sbjct: 882  QEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKR 941

Query: 923  KLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEE 982
            KL+D   +L+    D++  LA +E ++     + + L +   ++A   E      ++ + 
Sbjct: 942  KLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTE---EMAGLDEIIAKLTKEKKA 998

Query: 983  AQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ-- 1040
             Q+ H   L   Q   + ++ L   K+KLE QVD L+   +Q +K    LE   +K +  
Sbjct: 999  LQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGD 1058

Query: 1041 -HLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNV 1099
              L +E  ++  N     +  L  +D   +    + ++  +  SQ ++ L         +
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118

Query: 1100 WHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALE 1159
               L AE  A    ++     +R +      L+ A        A++ ++  +       +
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG------ATSVQIEMNKKREAEFQ 1172

Query: 1160 DMRKNLEKETRHLDEMKSAMRKGH----NLLKKKEEKLNQLESSLWEEASD 1206
             MR++LE+ T   +   +A+RK H      L ++ + L +++  L +E S+
Sbjct: 1173 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1223


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score =  120 bits (302), Expect = 7e-27
 Identities = 194/790 (24%), Positives = 342/790 (43%), Gaps = 96/790 (12%)

Query: 362  EEAAKEPKKKASALEEGSSD-----ASQELEISEHMKEPQLSDS-IASDPKSFHGLDFGF 415
            E+   E ++  +AL E           QE E++   +E   + + +A +  +   L+   
Sbjct: 975  EQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRL 1034

Query: 416  RSRISEHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEE------ 469
            ++ ++E  ++   L   L  A  +       E KD   +    L++ Q K LEE      
Sbjct: 1035 QNALNEQRVEFATLQEALAHALTEK------EGKDQELAKLRGLEAAQIKELEELRQTVK 1088

Query: 470  RLSPPLPHEERAQ---SPPRSLATEEEPPQGPEGQPEWKEAEELGE------DSAASLSL 520
            +L   L  +E+     S  +S A     P GP+ +    E  +L +      + A SL  
Sbjct: 1089 QLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLER 1148

Query: 521  QLSLQREQAPSPPAACEKGKEQ-HSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTE 579
             L  +R       +A E  + Q   +A+ELG  Q      + ++A   T          E
Sbjct: 1149 SLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE 1208

Query: 580  ---PVAPPEQLSE---AALKAMEEAVA----QVLEQDQRHLLESKQEKMQQLREKLCQEE 629
                VA   Q +E   + + ++EE V+    QVLE++     ESK+ K   + E    ++
Sbjct: 1209 WKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEG----ESKELKRLVMAESEKSQK 1264

Query: 630  EEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREE-ESQRLSW--LRAQVQSSTQADED 686
             EE LRL Q +  S S+       A+ EE   +REE E QR++   LR ++ S  +  E+
Sbjct: 1265 LEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEE 1324

Query: 687  ---QIRAEQEASLQKLREELESQQKAERASLEQKNRQML------EQLKEEIEASEKSEQ 737
               +++A QE   QK  E+  S  + E  S +    ++L      +QL+ E  A+EK  +
Sbjct: 1325 LGQELKAWQEKFFQK--EQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHR 1382

Query: 738  AALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAK---HREVVSSLQK 794
              L  +K+ A     E L  +R+       ++  AE ER    L A+   + E +S L+K
Sbjct: 1383 EELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKK 1442

Query: 795  KIQEAQQK-----EEAQLQKCLGQVEHRVHQKSY--HVAGYEHELSSLLREKRQEVEGEH 847
                  ++     E A L +   +VE    ++ Y   +A    +  + L E ++E +   
Sbjct: 1443 AHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQST- 1501

Query: 848  ERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQH 907
             R L+ M  +++    K       EER++  E    LT ++E        +LE  ++EQ 
Sbjct: 1502 ARELEVMTAKYEGAKVKV-----LEERQRFQEERQKLTAQVE--------QLEVFQREQT 1548

Query: 908  KRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVA 967
            K++E+L        +KL D +   + + + +KA  A     ++ A+R + QL ++Q Q++
Sbjct: 1549 KQVEEL-------SKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 968  LKSEEATATHQQLEEAQKEHTHLLQSNQQLRE---ILDELQARKLKLESQVDLLQAQSQQ 1024
             K + A     Q+E+A+  +    Q NQ+L+E    L++LQ    +L ++ + L  + Q 
Sbjct: 1602 QKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQ- 1660

Query: 1025 LQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQ 1084
             Q    + EAE Q  +HL  +V   E   +     D  + DL K        +     ++
Sbjct: 1661 -QAGLKTKEAE-QTCRHLTAQVRSLEAQVA---HADQQLRDLGKFQVATDALKSREPQAK 1715

Query: 1085 SKEDLYLDSL 1094
             + DL +DSL
Sbjct: 1716 PQLDLSIDSL 1725



 Score =  100 bits (248), Expect = 1e-20
 Identities = 172/765 (22%), Positives = 335/765 (43%), Gaps = 102/765 (13%)

Query: 451  DSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEEL 510
            D +S++DEL+ + ++  +             Q   R     E+    P    E KE EEL
Sbjct: 225  DERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPL---EPKELEEL 281

Query: 511  GEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAE-ELGPGQEEAEDPEEKVAVSPTP 569
              D   SL+++L    +Q       C+  K + SQ + ++    EE  D   K+      
Sbjct: 282  -RDKNESLTMRLHETLKQ-------CQDLKTEKSQMDRKINQLSEENGDLSFKLR----- 328

Query: 570  PVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEE 629
                     E  +  +QL +A L  + E  ++  ++      + ++E    L++K C EE
Sbjct: 329  ---------EFASHLQQLQDA-LNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEE 378

Query: 630  EEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIR 689
            + EIL   Q K   L     +LQ    +E+  +  +  Q L  L+ Q  ++  A+  Q++
Sbjct: 379  KNEIL---QGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQ-LETLK-QEAATLAANNTQLQ 433

Query: 690  AEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQ 749
            A  E  L+  R + E++  AER   E++ +Q L  L  ++++S  +            L 
Sbjct: 434  ARVE-MLETERGQQEAKLLAERGHFEEE-KQQLSSLITDLQSSISN------------LS 479

Query: 750  QLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQE----AQQKEEA 805
            Q +E+LE           + H A L    +SL ++   + +++Q++ QE     QQ +E 
Sbjct: 480  QAKEELE--------QASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531

Query: 806  QLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKA 865
            Q Q  L Q   +  Q S  +     +LSS L++K Q+++   E++ +  +++H Q +A A
Sbjct: 532  QAQ--LAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQ-EATRQDHAQQLATA 588

Query: 866  REQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQ 925
             E+ EA  R++ A L      +LE L++    +LE + Q+Q +   + R   +    + Q
Sbjct: 589  AEEREASLRERDAAL-----KQLEALEKEKAAKLE-ILQQQLQVANEARDSAQTSVTQAQ 642

Query: 926  DLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVA-----LKSEEATATHQQL 980
              + +L  + ++++A +       ETAR+E+    + Q QVA     L+SE+  AT ++ 
Sbjct: 643  REKAELSRKVEELQACV-------ETARQEQH---EAQAQVAELELQLRSEQQKATEKER 692

Query: 981  EEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK-- 1038
               +K+     Q  +QL+ + + L+  K  LE +        ++ Q+  S L+AE +   
Sbjct: 693  VAQEKD-----QLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDLRKSLG---TNQTKEVSSSLSQSKEDLYLDSLS 1095
            +QH      +EE  A         +E   + LG     +T+ +   L+++    +     
Sbjct: 748  EQHKRERKELEEERAGRK-----GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESE 802

Query: 1096 SHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGI 1155
               +   ++A       +++   Q     + +   LK   +  R EL   QE  +   GI
Sbjct: 803  CEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQEL---QEAKEKVAGI 859

Query: 1156 KALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL 1200
            ++  +++  + ++   L E+ + + +    +++KE +  +L   L
Sbjct: 860  ESHSELQ--ISRQQNELAELHANLARALQQVQEKEVRAQKLADDL 902



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 179/803 (22%), Positives = 333/803 (41%), Gaps = 95/803 (11%)

Query: 447  EDKDDSQSSQDELQS--KQSKG-LEE---RLSPPLPHEERA----QSPPRSLATEEEPPQ 496
            ++KD  Q     L+   K +KG LEE   R +  L  ++R     ++  RSL  + +   
Sbjct: 695  QEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHK--- 751

Query: 497  GPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEA 556
                    +E +EL E+ A    L+  LQ           + G+   ++ E L     EA
Sbjct: 752  --------RERKELEEERAGRKGLEARLQ-----------QLGEAHQAETEVLRRELAEA 792

Query: 557  EDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQE 616
               +   A S    +  EV +        Q  EA   AM +     L+++     E  ++
Sbjct: 793  MAAQH-TAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE----CEKARQ 847

Query: 617  KMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQ 676
            ++Q+ +EK+   E    L++ +Q+ + L+ L   L +A+++ + +  E  +Q+L+   + 
Sbjct: 848  ELQEAKEKVAGIESHSELQISRQQNE-LAELHANLARALQQVQEK--EVRAQKLADDLST 904

Query: 677  VQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSE 736
            +Q    A   ++ A  E  ++K  E+ E+  +       +   +  E L+E+      S 
Sbjct: 905  LQEKMAATSKEV-ARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCST 963

Query: 737  QAALNAAKEKA------LQQLREQL----------EGERKEAVATLEKEHSAELERLCSS 780
            QAAL A + +A      L++LR  L           G+++  VA L +E       L   
Sbjct: 964  QAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALE 1023

Query: 781  LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKR 840
             +A   E+   LQ  + E Q+ E A LQ+ L    H + +K     G + EL+ L   + 
Sbjct: 1024 -KAARAELEMRLQNALNE-QRVEFATLQEALA---HALTEKE----GKDQELAKLRGLEA 1074

Query: 841  QEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELE 900
             +++   E R   +K+  +Q+  K +E       +  A      TG      RA   +LE
Sbjct: 1075 AQIKELEELR-QTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133

Query: 901  TVRQEQHKRLEDLRRR-------HREQERKLQDLELDLETRAKDV-KARLALLEVQEETA 952
               Q+Q ++ + L R          E++  L+ L+  LE +A+++  ++ AL   Q E A
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193

Query: 953  R-REKQQLL-----DVQRQVALKSEEATATHQQLEEAQKEHTHLLQS-------NQQLRE 999
              R K Q       + + QVA   +EA   +  +   ++E + L +        +++L+ 
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKR 1253

Query: 1000 ILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEP 1059
            ++     +  KLE ++ LLQA++       +   +  +++   LRE   ++  AS +   
Sbjct: 1254 LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQ 1313

Query: 1060 DLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQ 1119
            +L  +  R      + K       Q ++ L    L   +   L+S    A    ++   +
Sbjct: 1314 ELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAE 1373

Query: 1120 QTRSMRRRQTALKAAQQ---HWRHELASAQEVAKD--PPGIKALEDMR--KNLEKETRHL 1172
            Q  + +R +  L+ ++Q     R EL  AQ    +  P   K  E  R  + L  E    
Sbjct: 1374 QAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASY 1433

Query: 1173 DEMKSAMRKGHNLLKKKEEKLNQ 1195
             E  S ++K H LL ++   L +
Sbjct: 1434 AEQLSMLKKAHGLLAEENRGLGE 1456



 Score = 30.8 bits (68), Expect = 10.0
 Identities = 26/129 (20%), Positives = 55/129 (42%), Gaps = 1/129 (0%)

Query: 1161 MRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVT 1220
            ++K L  E  + DE++  + +   LL +K+ ++  ++  +   A        SP +    
Sbjct: 219  LKKQLADERSNRDELELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKEL 278

Query: 1221 FDLSDM-DSLSSESSESFSPPHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQLSSVL 1279
             +L D  +SL+    E+          + ++D   +  S +   LS  LR+ +S L  + 
Sbjct: 279  EELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQ 338

Query: 1280 SILDSLNPQ 1288
              L+ L  +
Sbjct: 339  DALNELTEE 347


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score =  120 bits (300), Expect = 1e-26
 Identities = 182/779 (23%), Positives = 329/779 (42%), Gaps = 118/779 (15%)

Query: 553  QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE 612
            +EE    EE++       ++ E R TE      QL    L+  E+  A+     +   L 
Sbjct: 844  EEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELR 903

Query: 613  SKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSW 672
            ++    +Q  E++C + E  +    +++ Q L + ++++Q+ I+E E ++ EEES R   
Sbjct: 904  ARLTAKKQELEEICHDLEARV-EEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR--- 959

Query: 673  LRAQVQSSTQADEDQIRAEQEASLQKLREE---LESQQ---KAERASLEQKNRQMLEQLK 726
             + Q++  T           EA L+KL EE   LE Q      E+  LE +  +    L 
Sbjct: 960  QKLQLEKVT----------TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009

Query: 727  EEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHR 786
            EE E S+    A L    E  +  L E+L  E K+           ELE+    LE    
Sbjct: 1010 EEEEKSK--SLAKLKNKHEAMITDLEERLRREEKQ---------RQELEKTRRKLEGDST 1058

Query: 787  EV---VSSLQKKIQEAQQ---KEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKR 840
            ++   ++ LQ +I E +    K+E +LQ  L +VE    QK+  +     EL S + E +
Sbjct: 1059 DLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKI-RELESQISELQ 1117

Query: 841  QEVEGEHERR-------------LDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGE 887
            +++E E   R             L+ +K E +  +     Q E   R +R + +  L   
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQEL--RSKREQEVNILKKT 1175

Query: 888  LERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEV 947
            LE   + HE +++ +RQ+  + +E+L  +  + +R   +LE   +T           LE 
Sbjct: 1176 LEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQT-----------LEN 1224

Query: 948  QEETARREKQQLLDVQRQVALKSEEATATHQQLE----EAQKEHTHLLQSNQQLREILDE 1003
            +      E + LL  +     K ++  A  Q+L+    E ++  T L     +L+  LD 
Sbjct: 1225 ERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDN 1284

Query: 1004 LQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHI 1063
            +      L SQ D   ++S +L K FS+LE++ Q  Q LL+E                  
Sbjct: 1285 VTG----LLSQSD---SKSSKLTKDFSALESQLQDTQELLQE------------------ 1319

Query: 1064 EDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRS 1123
            E+ +K   + + K+V    +  +E L  +  + HN+   ++     +   K+ +      
Sbjct: 1320 ENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGC 1379

Query: 1124 M-------RRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMK 1176
            +       R+ Q  L+   Q  RHE    ++VA        LE  +  L++E   L    
Sbjct: 1380 LETAEEVKRKLQKDLEGLSQ--RHE----EKVA----AYDKLEKTKTRLQQELDDLLVDL 1429

Query: 1177 SAMRKGHNLLKKKEEKLNQL---ESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSES 1233
               R+    L+KK++K +QL   E ++  + ++E     +  ++  T  LS   +L  E+
Sbjct: 1430 DHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARAL-EEA 1488

Query: 1234 SESFSPPHR--EWWRQQRID--STPSLTSRKIHGLSHSLRQISSQLSSVLSILDSLNPQ 1288
             E  +   R  + +R +  D  S+     + +H L  S R +  Q+  + + L+ L  +
Sbjct: 1489 MEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDE 1547



 Score =  110 bits (275), Expect = 1e-23
 Identities = 180/847 (21%), Positives = 356/847 (42%), Gaps = 158/847 (18%)

Query: 508  EELGEDSAASLSLQLS----------LQREQAPSPPAACEKGKEQHSQAEELGPGQEEAE 557
            E+L E+ +A   LQL           L+ EQ       C+  KE+    + +        
Sbjct: 950  EQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT 1009

Query: 558  DPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEK 617
            + EEK               ++ +A  +   EA +  +EE + +  E+ QR  LE  + K
Sbjct: 1010 EEEEK---------------SKSLAKLKNKHEAMITDLEERLRR--EEKQRQELEKTRRK 1052

Query: 618  MQ------------------QLREKLCQEEEE---EILRLHQ---QKEQSLSSLRE---- 649
            ++                  +L+ +L ++EEE    + R+ +   QK  +L  +RE    
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112

Query: 650  --RLQKAIEEEEARMREEESQR------LSWLRAQVQSS--TQADEDQIRAEQEASLQKL 699
               LQ+ +E E A   + E Q+      L  L+ +++ +  + A + ++R+++E  +  L
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172

Query: 700  REELESQQKAERASLE---QKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLE 756
            ++ LE + K   A ++   QK+ Q +E+L E++E +++     + A  EKA Q L  +  
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKR-----VKANLEKAKQTLENERG 1227

Query: 757  GERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEH 816
                E    L+ +  +E +R     + +  +V  +  ++++     +  +LQ  L  V  
Sbjct: 1228 ELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTG 1287

Query: 817  RVHQ---KSYHVAGYEHELSSLLREKRQEVEGEHERRLD---KMKEEHQQVMAKAREQYE 870
             + Q   KS  +      L S L++ ++ ++ E+ ++L    K+K+   +  +   +  E
Sbjct: 1288 LLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE 1347

Query: 871  AEERKQRAEL-LGHLTGELERLQRAHEREL------ETVRQEQHKRLEDLRRRHREQERK 923
             EE K   E  +  L  ++  +++  E  +      E V+++  K LE L +RH E+   
Sbjct: 1348 EEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAA 1407

Query: 924  LQDLELDLETRAKDVKARLALLEVQEETA------RREKQQLLDVQRQVALKSEE----- 972
               LE       +++   L  L+ Q ++A      +++  QLL  ++ ++ K  E     
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRA 1467

Query: 973  ----------ATATHQQLEEAQKEHTHLLQSNQQLREILD--------------ELQARK 1008
                      A +  + LEEA ++   L + N+Q R  ++              EL+  K
Sbjct: 1468 EAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSK 1527

Query: 1009 LKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDL-----HI 1063
              LE QV+ ++ Q ++L+      E +A +   L  EV ++   A   FE DL       
Sbjct: 1528 RALEQQVEEMKTQLEELED-----ELQATEDAKLRLEVNLQAMKA--QFERDLQGRDEQS 1580

Query: 1064 EDLRKSLGTNQTKEVSSSL------------SQSKEDLYLDSLSSHNVWHLLSAEGVALR 1111
            E+ +K L   Q +E+ + L            ++ K ++ L  L +H +         A++
Sbjct: 1581 EEKKKQL-VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAH-IDSANKNRDEAIK 1638

Query: 1112 SAKEFLVQQTRSMRR-------RQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKN 1164
              ++   Q    MR        R+  L  A+++ +   +   E+ +    + A E  ++ 
Sbjct: 1639 QLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQ 1698

Query: 1165 LEKETRHL-DEMKSAMRKGHNLLKKK---EEKLNQLESSLWEEASDEGTLGGSPTKKAVT 1220
             ++E   L DE+ ++  KG   L++K   E ++ QLE  L EE  +   +     K  + 
Sbjct: 1699 AQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQ 1758

Query: 1221 FDLSDMD 1227
             D  + D
Sbjct: 1759 IDQINTD 1765



 Score =  108 bits (271), Expect = 3e-23
 Identities = 217/987 (21%), Positives = 413/987 (41%), Gaps = 158/987 (16%)

Query: 342  ASEKEAPEDTVDAGEEGSRREEAAK-EPKKKASALEEGSSDASQ----------ELEISE 390
            A  K   E  +   EE  RREE  + E +K    LE  S+D S           EL++  
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQL 1078

Query: 391  HMKEPQLSDSIASDPKSFHGLDFGFR------SRISEHLLDVDVLSPVLGGACRQAQQPL 444
              KE +L  ++A   +     +   +      S+ISE   D++        A +Q ++ L
Sbjct: 1079 AKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ-KRDL 1137

Query: 445  G---------IEDKDDSQSSQDELQSKQS-------KGLEERLSPPLPHEERAQS--PPR 486
            G         +ED  DS ++Q EL+SK+        K LEE       HE + Q      
Sbjct: 1138 GEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKT---HEAQIQEMRQKH 1194

Query: 487  SLATEE---EPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQH 543
            S A EE   +  Q    +   ++A++  E+    L+ ++ +  +          K K+  
Sbjct: 1195 SQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSE---HKRKKVE 1251

Query: 544  SQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVL 603
            +Q +EL     E E    ++A   T         T  ++  +  S    K      +Q+ 
Sbjct: 1252 AQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQL- 1310

Query: 604  EQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMR 663
             QD + LL+ +  +   L  KL Q E+E+            +S RE+L+   EEEEA+  
Sbjct: 1311 -QDTQELLQEENRQKLSLSTKLKQVEDEK------------NSFREQLE---EEEEAKHN 1354

Query: 664  EEESQRLSWLRAQVQSSTQADEDQIRAEQEAS--LQKLREELE--SQQKAERAS----LE 715
             E+  +++ L AQV    +  ED +   + A    +KL+++LE  SQ+  E+ +    LE
Sbjct: 1355 LEK--QIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

Query: 716  QKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELE 775
            +   ++ ++L + +   +   Q+A N  K+   Q+  +QL  E K    T+  +++ E +
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKK---QKKFDQLLAEEK----TISAKYAEERD 1465

Query: 776  RLCSSLEAKHREVVS-SLQKKIQEAQQKEEAQLQKCLGQVEHRVHQ---KSYHVAGYEHE 831
            R  +  EA+ +E  + SL + ++EA + ++A+L++   Q    +         V    HE
Sbjct: 1466 R--AEAEAREKETKALSLARALEEAME-QKAELERLNKQFRTEMEDLMSSKDDVGKSVHE 1522

Query: 832  LSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERL 891
            L    R   Q+VE E + +L+++++E Q            E+ K R E+       L+ +
Sbjct: 1523 LEKSKRALEQQVE-EMKTQLEELEDELQAT----------EDAKLRLEV------NLQAM 1565

Query: 892  QRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEET 951
            +   ER+L+   ++  ++ + L R+ RE E +L+D   + + R+  V AR  L       
Sbjct: 1566 KAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED---ERKQRSMAVAARKKL------- 1615

Query: 952  ARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKL 1011
                +  L D++  +   ++      +QL + Q +    ++     R   +E+ A+  + 
Sbjct: 1616 ----EMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKEN 1671

Query: 1012 ESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNAS----------------- 1054
            E ++  ++A+  QLQ+  ++ E   ++ Q    E+  E  N+S                 
Sbjct: 1672 EKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARI 1731

Query: 1055 PHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLD---SLSSHNVWHLLSAEGVALR 1111
               E +L  E     L  ++ K+ +  + Q   DL L+   +  + N    L  +   L+
Sbjct: 1732 AQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELK 1791

Query: 1112 SAKEFLVQQTRSMRRRQ-TALKAAQQHWRHEL--------ASAQEVAKDPPGIK----AL 1158
               + +    +S  +   TAL+A       +L        A+ ++V +    +K     +
Sbjct: 1792 VKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQV 1851

Query: 1159 EDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESS---LWEEASDEGTLGGSPT 1215
            +D R+N E+     D+  + +++    L++ EE+  +  +S   L  E  D      + T
Sbjct: 1852 DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED-----ATET 1906

Query: 1216 KKAVTFDLSDMDSLSSESSESFSPPHR 1242
              A+  ++S + +        F  P R
Sbjct: 1907 ADAMNREVSSLKNKLRRGDLPFVVPRR 1933



 Score =  103 bits (258), Expect = 9e-22
 Identities = 197/920 (21%), Positives = 377/920 (40%), Gaps = 193/920 (20%)

Query: 223  EEESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKKDVSLDSDAAGPPTPC 282
            EEE+  +++  + + +R L   I  L  D E E + R    ++K+D+  + +A       
Sbjct: 1093 EEEAAQKNM--ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA------- 1143

Query: 283  KPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKA 342
                      L + +      + A+  L  K E E +        +  K     ++  +A
Sbjct: 1144 ----------LKTELEDTLDSTAAQQELRSKREQEVN--------ILKKTLEEEAKTHEA 1185

Query: 343  SEKEAPEDTVDAGEEGSRREEAAKEPK----KKASALEEGSSDASQELEI-------SEH 391
              +E  +    A EE + + E  K  K    K    LE    + + E+++       SEH
Sbjct: 1186 QIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH 1245

Query: 392  MK---EPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACRQAQQPLGIED 448
             +   E QL +           + F    R+   L D      V      +     G+  
Sbjct: 1246 KRKKVEAQLQEL---------QVKFNEGERVRTELADKVTKLQV------ELDNVTGLLS 1290

Query: 449  KDDSQSSQDELQSKQSKGLEERL--SPPLPHEERAQSPPRSLAT-----EEEPPQGPEGQ 501
            + DS+SS+    +K    LE +L  +  L  EE  Q    SL+T     E+E     E  
Sbjct: 1291 QSDSKSSK---LTKDFSALESQLQDTQELLQEENRQK--LSLSTKLKQVEDEKNSFREQL 1345

Query: 502  PEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEE 561
             E +EA+   E   A+L  Q++  +++        E  +E   + ++   G  +      
Sbjct: 1346 EEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQ------ 1399

Query: 562  KVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQL 621
                          R  E VA  ++L +   +  +E    +++ D +       EK Q+ 
Sbjct: 1400 --------------RHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKK 1445

Query: 622  REKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSST 681
             ++L  EE+    +  ++++++ +  RE+  KA+    A + E   Q+    R   Q  T
Sbjct: 1446 FDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARA-LEEAMEQKAELERLNKQFRT 1504

Query: 682  QADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSE----- 736
            +  ED + ++ +    K   ELE  ++A    +E+   Q LE+L++E++A+E ++     
Sbjct: 1505 EM-EDLMSSKDDVG--KSVHELEKSKRALEQQVEEMKTQ-LEELEDELQATEDAKLRLEV 1560

Query: 737  -QAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKK 795
               A+ A  E+ LQ   EQ E ++K+ V  + +E  AELE      E K R +  + +KK
Sbjct: 1561 NLQAMKAQFERDLQGRDEQSEEKKKQLVRQV-REMEAELED-----ERKQRSMAVAARKK 1614

Query: 796  IQ---------------------EAQQKEEAQLQKCLGQV-----------------EHR 817
            ++                     +  +K +AQ++ C+ ++                 E +
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674

Query: 818  VHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK----------EEHQQVMAK-AR 866
            +      +   + EL++  R KRQ  + E +   D++           EE +++ A+ A+
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQ-AQQERDELADEIANSSGKGALALEEKRRLEARIAQ 1733

Query: 867  EQYEAEERKQRAELLGHLTGELE----------RLQRAHERELETVRQEQHKRLEDLRRR 916
             + E EE +   EL+     +             L+R+H ++ E  RQ+       L R+
Sbjct: 1734 LEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ-------LERQ 1786

Query: 917  HREQERKLQDLELDLETRAK----DVKARLALLEVQEETARREKQ-----------QLLD 961
            ++E + KLQ++E  ++++ K     ++A++A LE Q +   +E+Q           +L D
Sbjct: 1787 NKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEKKLKD 1846

Query: 962  VQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQ---ARKLKLESQVDLL 1018
            V  QV    +E     Q  ++A K  T L Q  +QL E  +E Q   A + KL+ +++  
Sbjct: 1847 VLLQV---DDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDA 1903

Query: 1019 QAQSQQLQKHFSSLEAEAQK 1038
               +  + +  SSL+ + ++
Sbjct: 1904 TETADAMNREVSSLKNKLRR 1923



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 127/540 (23%), Positives = 250/540 (46%), Gaps = 68/540 (12%)

Query: 696  LQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQL 755
            LQ  R+E E   K E     ++ +   E    E+E    + Q+ L A K +  +QL+ + 
Sbjct: 838  LQVSRQEEEMMAKEEELVKVREKQLAAENRLTEME----TLQSQLMAEKLQLQEQLQAET 893

Query: 756  E--GERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQ 813
            E   E +E  A L  +   ELE +C  LEA+  E     +++  +  Q E+ ++Q+ + +
Sbjct: 894  ELCAEAEELRARLTAK-KQELEEICHDLEARVEE-----EEERCQHLQAEKKKMQQNIQE 947

Query: 814  VEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEE 873
            +E ++          E E S+  R+K Q  +   E +L K++EE  Q++ + +    A+E
Sbjct: 948  LEEQL----------EEEESA--RQKLQLEKVTTEAKLKKLEEE--QIILEDQNCKLAKE 993

Query: 874  RK----QRAELLGHLTGE------LERLQRAHERELETVRQEQHKRLEDLRRRHREQERK 923
            +K    + AE   +LT E      L +L+  HE  + T  +E+ +R E  R+   +  RK
Sbjct: 994  KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMI-TDLEERLRREEKQRQELEKTRRK 1052

Query: 924  LQDLELDLETRAKDVKARLALLEVQEETARREKQQLL------DVQRQVALKS--EEATA 975
            L+    DL  +  +++A++A L++Q      E Q  L        Q+ +ALK   E  + 
Sbjct: 1053 LEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQ 1112

Query: 976  THQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKH------- 1028
              +  E+ + E     ++ +Q R++ +EL+A K +LE  +D   AQ +   K        
Sbjct: 1113 ISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNIL 1172

Query: 1029 FSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKED 1088
              +LE EA+  +  ++E+  + + A         +E+L + L   QTK V ++L ++K+ 
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQA---------VEELAEQL--EQTKRVKANLEKAKQT 1221

Query: 1089 LYLD-SLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQE 1147
            L  +    ++ V  LL  +G +    K+ +  Q + ++ +    +  +     ++   Q 
Sbjct: 1222 LENERGELANEVKVLLQGKGDSEHKRKK-VEAQLQELQVKFNEGERVRTELADKVTKLQV 1280

Query: 1148 VAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE 1207
               +  G+ +  D + +  K T+    ++S ++    LL+++  +   L + L ++  DE
Sbjct: 1281 ELDNVTGLLSQSDSKSS--KLTKDFSALESQLQDTQELLQEENRQKLSLSTKL-KQVEDE 1337



 Score = 51.2 bits (121), Expect = 7e-06
 Identities = 62/305 (20%), Positives = 125/305 (40%), Gaps = 44/305 (14%)

Query: 909  RLEDLRRRHREQERKLQDLELDLETRAKDVKA--RLALLEVQEETARREKQQLLDVQRQV 966
            +++ L +  R++E  +   E  ++ R K + A  RL  +E  +     EK QL       
Sbjct: 833  KVKPLLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQL------- 885

Query: 967  ALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQ 1026
                E+  A  +   EA++    L    Q+L EI  +L+AR  + E +   LQA+ +++Q
Sbjct: 886  ---QEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQ 942

Query: 1027 KHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSK 1086
            ++   LE + ++++   +++ +E+          +  E   K L   Q      +   +K
Sbjct: 943  QNIQELEEQLEEEESARQKLQLEK----------VTTEAKLKKLEEEQIILEDQNCKLAK 992

Query: 1087 EDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQ 1146
            E   L+                      EF    T    + ++  K   +H        +
Sbjct: 993  EKKLLED------------------RIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEE 1034

Query: 1147 EVAKDPPGIKALEDMRKNLEKETRHLD----EMKSAMRKGHNLLKKKEEKLNQLESSLWE 1202
             + ++    + LE  R+ LE ++  L     E+++ + +    L KKEE+L    + + E
Sbjct: 1035 RLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE 1094

Query: 1203 EASDE 1207
            EA+ +
Sbjct: 1095 EAAQK 1099


>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
          Length = 1476

 Score =  119 bits (297), Expect = 3e-26
 Identities = 223/938 (23%), Positives = 396/938 (42%), Gaps = 166/938 (17%)

Query: 314  EENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKAS 373
            EEN + E ++ R+L  P   P G  P   +     ++  +A  E  R     +E ++   
Sbjct: 417  EENVELELELQRSLEPPPGSP-GEAPLAGAAPSLQDEVREA--EAGRLRTLERENRELRG 473

Query: 374  ALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISE------HLLDV- 426
             L+        +  + E  +E  +   +   P++    D   +  + +        LD+ 
Sbjct: 474  LLQVLQGQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFDHSPQGLVQKARDGGPQALDLA 533

Query: 427  -DVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ-----------SKQSKG--LEERLS 472
               L  VL  +    Q P       D Q ++  LQ           S Q  G  +E + S
Sbjct: 534  PPALDSVLEASAECPQAP-----DSDPQEAESPLQAAAMDPQASDWSPQESGSPVETQES 588

Query: 473  PPLPHEERAQSPPRSLATEEEPPQGPE----------GQPEWKEAEELGEDSAASLSL-Q 521
            P       +   P S+A    PPQGP           G+ E +EA + GE    +  L Q
Sbjct: 589  PEKAGRRSSLQSPASVA----PPQGPGTKIQAPQLLGGETEGREAPQ-GELVPEAWGLRQ 643

Query: 522  LSLQREQAPSPPAACE-KGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPV--------- 571
               + +  PS P++ + + +E  +Q  +L  GQ EA + ++++  +   P          
Sbjct: 644  EGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSE 703

Query: 572  -SPEVRSTEPVAPPEQLSE--AALKAMEEAVAQVLE---------QDQRHLLESKQEKMQ 619
             + EV+  E   P E L+   A  +A+ E VAQ+           + Q   LE++  +  
Sbjct: 704  GALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELEAQARKLEAQNTEAA 763

Query: 620  QLREKLCQEEEEEILRLHQQKEQSL---SSLRERLQKAIEEEEARMREEES--------- 667
            +L ++L Q    E    H++ E      + LRE ++ A +E E+  +E E+         
Sbjct: 764  RLSKELAQARRAEA-EAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822

Query: 668  -QRLSWLR--AQVQSSTQADEDQIRAEQEASLQKLRE-ELESQQK-AERASLEQ---KNR 719
             +R  W R  +++++ ++A E++++  +    Q L E E E ++K A +A LE+   + +
Sbjct: 823  RERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERREKEALQAELEKAVVRGK 882

Query: 720  QM---LEQLKEEIE--ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAEL 774
            ++   LE L+ E+E  A E+ E      ++ +  Q L ++LE E  +A AT ++E   EL
Sbjct: 883  ELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAEL-QAAATSKEEALMEL 941

Query: 775  ERLCSSLEAK-----------------HREVVSSLQKKIQEAQQK------EEAQLQKCL 811
            +     LE +                   ++V +   ++ E ++       E+A LQ   
Sbjct: 942  KTRALQLEEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVERSNAMLVAEKAALQ--- 998

Query: 812  GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMK---EEHQQVMAKAREQ 868
            GQ++H   Q    + G   EL  LL+ +R +   EH  RL   K   E   Q + +  E 
Sbjct: 999  GQLQHLEGQLG-SLQGRAQEL--LLQSQRAQ---EHSSRLQAEKSVLEIQGQELHRKLEV 1052

Query: 869  YEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLE 928
             E E R  R +      G+ + L R H + L  +++ Q   LE L  RHR+ +  ++ LE
Sbjct: 1053 LEEEVRAAR-QSQEETRGQQQALLRDH-KALAQLQRRQEAELEGLLVRHRDLKANMRALE 1110

Query: 929  L---DLETRAKDVKARLALLEVQEETARREKQQLL-DVQRQVALKSEEATATHQQLEEAQ 984
            L   +L+ R + ++A+ A +E QE     E+++L+ D  RQ  L+ EE      + + AQ
Sbjct: 1111 LAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHRQRGLE-EELRRLQSEHDRAQ 1169

Query: 985  KEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK---KQH 1041
                 L +   +L+    EL+ R  +LE +   L+ QSQQL++    L+  A +   +  
Sbjct: 1170 MLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQLRESNQQLDLSACRLTTQCE 1229

Query: 1042 LLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWH 1101
            LL ++   +             E+ R+ L   Q      +LS+   +L   SL S +  H
Sbjct: 1230 LLTQLRSAQE------------EENRQLLAEVQ------ALSRENRELLERSLESRDHLH 1271

Query: 1102 LLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWR 1139
                     R  +E+L Q     R +Q  ++     +R
Sbjct: 1272 ---------REQREYLDQLNALRREKQKLVEKIMDQYR 1300



 Score = 53.1 bits (126), Expect = 2e-06
 Identities = 79/301 (26%), Positives = 135/301 (44%), Gaps = 39/301 (12%)

Query: 712 ASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHS 771
           AS++ ++R++  +  + +    +SE AA       A+Q++ +   G     V  L     
Sbjct: 146 ASVQCEHRELFIRHIQGLSLEVQSELAA-------AIQEVTQPGAG----VVLALSGPDP 194

Query: 772 AELERLCSSLEAKHREVVSSLQKKIQE----AQQKEEAQLQK---CLG-QVEHRVHQK-- 821
            EL    + LE   R ++ +L K  +E    AQ+  E  L++   CL  +   R   +  
Sbjct: 195 GELAP--AELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGP 252

Query: 822 SYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELL 881
           S+H+A       + LR  RQE+E + E  LD   E          +  EAE R+ R E  
Sbjct: 253 SHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEV---------QGLEAEIRRLRQEAQ 303

Query: 882 GHLTGELERLQRAHERELETVRQEQHK--RLEDLRRRHREQERKLQDLELDLETR---AK 936
             L+G+ +R +   E E E +R+   +  RL++  RR RE+ +  +  +  LE     + 
Sbjct: 304 A-LSGQAKRAELYRE-EAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSG 361

Query: 937 DVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQ 996
            ++A  ALLE Q E AR    +L + QR+  L        H +L+  + +   L + N +
Sbjct: 362 VLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVE 421

Query: 997 L 997
           L
Sbjct: 422 L 422



 Score = 39.3 bits (90), Expect = 0.028
 Identities = 72/309 (23%), Positives = 125/309 (40%), Gaps = 26/309 (8%)

Query: 584 PEQLSEAALKAMEEAVAQVLEQ--DQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKE 641
           P +L+ A L+ +  ++   L +   +R L   +  ++   RE LC   E       +   
Sbjct: 194 PGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSRAPAEGPS 253

Query: 642 QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLRE 701
             L+     LQ A  + + R   +E +  + L    Q+  Q  E +IR  ++ +     +
Sbjct: 254 HHLA-----LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQ 308

Query: 702 ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ--LEGER 759
              ++   E A   ++    L +L+EE+    +  QAA     E    QL E+  L G  
Sbjct: 309 AKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAA-----EAYKSQLEEERVLSGVL 363

Query: 760 KEAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH 819
           + + A LE++  A  ER C+ L    RE +  L+ ++ EA  +        L  + H+V 
Sbjct: 364 EASKALLEEQLEAARER-CARLHETQRENL-LLRTRLGEAHAE--------LDSLRHQVD 413

Query: 820 QKSYHVAGYEHELS-SLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRA 878
           Q +      E EL  SL        E         +++E ++  A      E E R+ R 
Sbjct: 414 QLAEENVELELELQRSLEPPPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENRELRG 473

Query: 879 ELLGHLTGE 887
            LL  L G+
Sbjct: 474 -LLQVLQGQ 481



 Score = 38.5 bits (88), Expect = 0.048
 Identities = 50/195 (25%), Positives = 79/195 (40%), Gaps = 37/195 (18%)

Query: 773 ELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVH---QKSYHVAGYE 829
           E E LC   EA  R         +       +AQL++   ++E +          V G E
Sbjct: 233 EREPLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLE 292

Query: 830 HELSSLLREK-------------RQEVEGEHER--RLDKMKEEHQQVMAK--AREQYEAE 872
            E+  L +E              R+E E   ER  RL +++EE ++   +  A E Y+++
Sbjct: 293 AEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQ 352

Query: 873 ERKQR----------AELLGHLTGELERLQRAHERE-----LETVRQEQHKRLEDLRRRH 917
             ++R          A L   L    ER  R HE +     L T   E H  L+ L  RH
Sbjct: 353 LEEERVLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSL--RH 410

Query: 918 REQERKLQDLELDLE 932
           +  +   +++EL+LE
Sbjct: 411 QVDQLAEENVELELE 425



 Score = 30.8 bits (68), Expect = 10.0
 Identities = 48/260 (18%), Positives = 101/260 (38%), Gaps = 19/260 (7%)

Query: 930  DLETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTH 989
            +LE  ++ +   L+ L  + +   +   +LL  +  + L+ E   A  +   E    H  
Sbjct: 201  ELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPE---APSRAPAEGPSHHLA 257

Query: 990  LLQSN-----QQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLR 1044
            L  +N     ++LR+ L+E     L  +++V  L+A+ ++L++   +L  +A++ +    
Sbjct: 258  LQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRRLRQEAQALSGQAKRAELYRE 317

Query: 1045 EVTVEENNAS--PHFEPDL-----HIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSH 1097
            E       A   P  + +L      ++         + + V S + ++ + L  + L + 
Sbjct: 318  EAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEERVLSGVLEASKALLEEQLEAA 377

Query: 1098 NV----WHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPP 1153
                   H    E + LR+       +  S+R +   L         EL  + E     P
Sbjct: 378  RERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAEENVELELELQRSLEPPPGSP 437

Query: 1154 GIKALEDMRKNLEKETRHLD 1173
            G   L     +L+ E R  +
Sbjct: 438  GEAPLAGAAPSLQDEVREAE 457


>gi|42794779 myosin 18A isoform b [Homo sapiens]
          Length = 2039

 Score =  118 bits (296), Expect = 4e-26
 Identities = 161/694 (23%), Positives = 301/694 (43%), Gaps = 81/694 (11%)

Query: 586  QLSEAALKAMEEAVAQV---LEQDQRHLLESK------QEKMQQLREKLCQE-------- 628
            QLSE  ++  +E + Q+   LE+ ++   E +      + ++ +L  +L  E        
Sbjct: 1250 QLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESAS 1309

Query: 629  ---EEEEILRLHQQKE-QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 684
               + E   RL  +KE + L +  + L+K +E  E  + E    R + +  +V       
Sbjct: 1310 QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369

Query: 685  EDQI---RAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALN 741
            E ++   RA +E    K R + E + K E   +EQ+N++ LE+   +++A  +  Q AL 
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQ 1426

Query: 742  AAKEKALQQLREQLEGERKEAVATLEKEHSAELE--RLCSSLEAKHREVVSSLQKKIQEA 799
              K+K  Q+L  +L+  +        + H  E +  R  S L   H E  +  +K  +E 
Sbjct: 1427 QLKKKC-QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE--AQREKLQREK 1483

Query: 800  QQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ--EVEGEHERRLDKMKEE 857
             Q+E+  L      ++ ++ +K   +AG+  ++ SL  E +     E + E  L K+K++
Sbjct: 1484 LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQ 1543

Query: 858  HQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRH 917
             + + AK ++Q   EE  ++A  +  L     RL+   ER  +T  +E   R E++    
Sbjct: 1544 LRDLEAKVKDQ--EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR 1601

Query: 918  REQERKLQDLELDLETRAKD----------VKARLALL--EVQEETARREKQQLLDVQRQ 965
            +  ++KL+ +E+ LE   +D          ++ +LA L  +V       EK+   D++R 
Sbjct: 1602 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1661

Query: 966  VALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE----ILDELQARKLKLESQVDLLQAQ 1021
             AL + +A      L+ +      + Q   QL E        ++ARK  +E +++ L  Q
Sbjct: 1662 KALLA-DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARK-AMEVEIEDLHLQ 1719

Query: 1022 SQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSS 1081
               + K  ++LE +  + Q        E+N      E D   ED+ + +  ++     +S
Sbjct: 1720 IDDIAKAKTALEEQLSRLQR-------EKNEIQNRLEEDQ--EDMNELMKKHKAAVAQAS 1770

Query: 1082 LSQSK-EDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQ--TRSMRRRQTALKAAQQHW 1138
               ++  DL      ++     L  +  AL+S  EFL Q    +S+  RQ A K  +   
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEA-KIRELET 1829

Query: 1139 RHELASAQEVAKDPPGIKALED----MRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLN 1194
            R E    Q        +K LE     +++N+EK T   D+  +A  +     K+ + +L 
Sbjct: 1830 RLEFERTQ--------VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR 1881

Query: 1195 QLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDS 1228
              +  + E A  E     S  K  +  DL  +++
Sbjct: 1882 DTKEEMGELARKEAE--ASRKKHELEMDLESLEA 1913



 Score = 87.4 bits (215), Expect = 9e-17
 Identities = 173/828 (20%), Positives = 341/828 (41%), Gaps = 141/828 (17%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPA-KASEKEAPEDTVDAGE-EGSRREEAAKEPK 369
            EK E E++E ++  + +  +     SE   + +  E+    +DA   E  R E+  KE +
Sbjct: 1271 EKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ 1330

Query: 370  KKASALEEGSSDASQELEISEHMKEPQLSDSIASDP----------KSFHGLDFGFRSRI 419
             +  AL++       E+  +  ++  +++  +  D           ++   +DF  + R+
Sbjct: 1331 TQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFT-KKRL 1389

Query: 420  SEHL---LDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQS--KQSKGLEERLSPP 474
             +     L+V+  +       RQ ++ LG + + DS+ SQ  LQ   K+ + L   L   
Sbjct: 1390 QQEFEDKLEVEQQNK------RQLERRLG-DLQADSEESQRALQQLKKKCQRLTAELQDT 1442

Query: 475  LPHEERAQSPPRSLATEEE------PPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQ 528
              H E  Q     L  ++            E Q E  + E+L  +    L+   SL+++ 
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502

Query: 529  APSPPAACEKGKEQHSQAEELGPGQEEAED--PEEKVAVSPTPPVSPEVRSTEPVAPP-- 584
                    EK  +     +++   + E +D   +E    +    V  ++R  E       
Sbjct: 1503 E-------EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE 1555

Query: 585  EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSL 644
            E+L E A         Q+LEQ +  L E + E+M+Q   K  +  +EE+    Q  ++ L
Sbjct: 1556 EELDEQA------GTIQMLEQAKLRL-EMEMERMRQTHSKEMESRDEEVEEARQSCQKKL 1608

Query: 645  SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELE 704
              +  +L++  E+++  +RE+          +++       DQ+      S ++LR++L+
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKR---------ELEGKLATLSDQVNRRDFESEKRLRKDLK 1659

Query: 705  SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVA 764
              +     +L    + ML+ LK              +A  ++ + QL+ QLE       A
Sbjct: 1660 RTK-----ALLADAQLMLDHLKN-------------SAPSKREIAQLKNQLEESEFTCAA 1701

Query: 765  TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYH 824
             ++   + E+E     +E  H ++    + K   A +++ ++LQ+   ++++R+ +    
Sbjct: 1702 AVKARKAMEVE-----IEDLHLQIDDIAKAKT--ALEEQLSRLQREKNEIQNRLEED--- 1751

Query: 825  VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQ----RAEL 880
                + +++ L+++ +  V  +  R L ++ +   Q+    +E+ E +E+ Q    + E 
Sbjct: 1752 ----QEDMNELMKKHKAAV-AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEF 1806

Query: 881  LGH--LTGELERLQRAHERELET---VRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
            L    +   L   Q A  RELET     + Q KRLE L  R +E   KL        T  
Sbjct: 1807 LEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKL--------TEE 1858

Query: 936  KDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQ 995
            +D   R+A    ++E  +R ++QL D       K E      ++ E ++K+H        
Sbjct: 1859 RD--QRIAAENREKEQNKRLQRQLRDT------KEEMGELARKEAEASRKKH-------- 1902

Query: 996  QLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASP 1055
            +L   L+ L+A    L++ + L   +   LQ      E E+ + + L+        N+  
Sbjct: 1903 ELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIED-EMESDENEDLI--------NSEG 1953

Query: 1056 HFEPDLHIED--------LRKSLGTNQTKEVSSSLSQSKEDLYLDSLS 1095
              + D  +ED        L K+ G ++      SL  S    Y  SL+
Sbjct: 1954 DSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLA 2001


>gi|28416946 myosin 18A isoform a [Homo sapiens]
          Length = 2054

 Score =  118 bits (296), Expect = 4e-26
 Identities = 161/694 (23%), Positives = 301/694 (43%), Gaps = 81/694 (11%)

Query: 586  QLSEAALKAMEEAVAQV---LEQDQRHLLESK------QEKMQQLREKLCQE-------- 628
            QLSE  ++  +E + Q+   LE+ ++   E +      + ++ +L  +L  E        
Sbjct: 1250 QLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESAS 1309

Query: 629  ---EEEEILRLHQQKE-QSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD 684
               + E   RL  +KE + L +  + L+K +E  E  + E    R + +  +V       
Sbjct: 1310 QLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGG 1369

Query: 685  EDQI---RAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALN 741
            E ++   RA +E    K R + E + K E   +EQ+N++ LE+   +++A  +  Q AL 
Sbjct: 1370 EWRLKYERAVREVDFTKKRLQQEFEDKLE---VEQQNKRQLERRLGDLQADSEESQRALQ 1426

Query: 742  AAKEKALQQLREQLEGERKEAVATLEKEHSAELE--RLCSSLEAKHREVVSSLQKKIQEA 799
              K+K  Q+L  +L+  +        + H  E +  R  S L   H E  +  +K  +E 
Sbjct: 1427 QLKKKC-QRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEE--AQREKLQREK 1483

Query: 800  QQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQ--EVEGEHERRLDKMKEE 857
             Q+E+  L      ++ ++ +K   +AG+  ++ SL  E +     E + E  L K+K++
Sbjct: 1484 LQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQ 1543

Query: 858  HQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRH 917
             + + AK ++Q   EE  ++A  +  L     RL+   ER  +T  +E   R E++    
Sbjct: 1544 LRDLEAKVKDQ--EEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEAR 1601

Query: 918  REQERKLQDLELDLETRAKD----------VKARLALL--EVQEETARREKQQLLDVQRQ 965
            +  ++KL+ +E+ LE   +D          ++ +LA L  +V       EK+   D++R 
Sbjct: 1602 QSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRT 1661

Query: 966  VALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE----ILDELQARKLKLESQVDLLQAQ 1021
             AL + +A      L+ +      + Q   QL E        ++ARK  +E +++ L  Q
Sbjct: 1662 KALLA-DAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARK-AMEVEIEDLHLQ 1719

Query: 1022 SQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSS 1081
               + K  ++LE +  + Q        E+N      E D   ED+ + +  ++     +S
Sbjct: 1720 IDDIAKAKTALEEQLSRLQR-------EKNEIQNRLEEDQ--EDMNELMKKHKAAVAQAS 1770

Query: 1082 LSQSK-EDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQ--TRSMRRRQTALKAAQQHW 1138
               ++  DL      ++     L  +  AL+S  EFL Q    +S+  RQ A K  +   
Sbjct: 1771 RDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEA-KIRELET 1829

Query: 1139 RHELASAQEVAKDPPGIKALED----MRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLN 1194
            R E    Q        +K LE     +++N+EK T   D+  +A  +     K+ + +L 
Sbjct: 1830 RLEFERTQ--------VKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLR 1881

Query: 1195 QLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDS 1228
              +  + E A  E     S  K  +  DL  +++
Sbjct: 1882 DTKEEMGELARKEAE--ASRKKHELEMDLESLEA 1913



 Score = 86.7 bits (213), Expect = 2e-16
 Identities = 176/829 (21%), Positives = 349/829 (42%), Gaps = 126/829 (15%)

Query: 312  EKEENEKSEPKICRNLVTPKADPTGSEPA-KASEKEAPEDTVDAGE-EGSRREEAAKEPK 369
            EK E E++E ++  + +  +     SE   + +  E+    +DA   E  R E+  KE +
Sbjct: 1271 EKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQ 1330

Query: 370  KKASALEEGSSDASQELEISEHMKEPQLSDSIASDP----------KSFHGLDFGFRSRI 419
             +  AL++       E+  +  ++  +++  +  D           ++   +DF  + R+
Sbjct: 1331 TQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFT-KKRL 1389

Query: 420  SEHL---LDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQS--KQSKGLEERLSPP 474
             +     L+V+  +       RQ ++ LG + + DS+ SQ  LQ   K+ + L   L   
Sbjct: 1390 QQEFEDKLEVEQQNK------RQLERRLG-DLQADSEESQRALQQLKKKCQRLTAELQDT 1442

Query: 475  LPHEERAQSPPRSLATEEE------PPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQ 528
              H E  Q     L  ++            E Q E  + E+L  +    L+   SL+++ 
Sbjct: 1443 KLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQL 1502

Query: 529  APSPPAACEKGKEQHSQAEELGPGQEEAED--PEEKVAVSPTPPVSPEVRSTEPVAPP-- 584
                    EK  +     +++   + E +D   +E    +    V  ++R  E       
Sbjct: 1503 E-------EKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQE 1555

Query: 585  EQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSL 644
            E+L E A         Q+LEQ +  L E + E+M+Q   K  +  +EE+    Q  ++ L
Sbjct: 1556 EELDEQA------GTIQMLEQAKLRL-EMEMERMRQTHSKEMESRDEEVEEARQSCQKKL 1608

Query: 645  SSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELE 704
              +  +L++  E+++  +RE+          +++       DQ+      S ++LR++L+
Sbjct: 1609 KQMEVQLEEEYEDKQKVLREKR---------ELEGKLATLSDQVNRRDFESEKRLRKDLK 1659

Query: 705  SQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVA 764
              +     +L    + ML+ LK              +A  ++ + QL+ QLE       A
Sbjct: 1660 RTK-----ALLADAQLMLDHLKN-------------SAPSKREIAQLKNQLEESEFTCAA 1701

Query: 765  TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYH 824
             ++   + E+E     +E  H ++    + K   A +++ ++LQ+   ++++R+ +    
Sbjct: 1702 AVKARKAMEVE-----IEDLHLQIDDIAKAKT--ALEEQLSRLQREKNEIQNRLEED--- 1751

Query: 825  VAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQ----RAEL 880
                + +++ L+++ +  V  +  R L ++ +   Q+    +E+ E +E+ Q    + E 
Sbjct: 1752 ----QEDMNELMKKHKAAV-AQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEF 1806

Query: 881  LGH--LTGELERLQRAHERELET---VRQEQHKRLEDLRRRHREQERKLQDLELDLETRA 935
            L    +   L   Q A  RELET     + Q KRLE L  R +E   KL        T  
Sbjct: 1807 LEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKL--------TEE 1858

Query: 936  KDVKARLALLEVQEETARREKQQLLDVQR---QVALKSEEATATHQQLE---EAQKEHTH 989
            +D   R+A    ++E  +R ++QL D +    ++A K  EA+    +LE   E+ +    
Sbjct: 1859 RD--QRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQ 1916

Query: 990  LLQSNQQL--REILDELQARKLKLESQ-----VDLLQAQSQQLQKHFSSLEAEAQKKQHL 1042
             LQ++ +L  + I D   A + ++ES      ++ LQ    + QK  + LE ++     L
Sbjct: 1917 SLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSEL 1976

Query: 1043 LREVTVEENNASPHFEPDLHIED---LRKSLGTNQTKEVSSSLSQSKED 1088
               V   ++  S +  P     D   L+ S  T+  K ++   S  + D
Sbjct: 1977 EDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHD 2025


>gi|16262452 cingulin [Homo sapiens]
          Length = 1203

 Score =  118 bits (295), Expect = 5e-26
 Identities = 194/837 (23%), Positives = 344/837 (41%), Gaps = 121/837 (14%)

Query: 503  EWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEK 562
            E K+ ++L E S   L  QL  + E+        E+ K +  Q+ +     +   D  E 
Sbjct: 378  EVKKRQKL-EPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGED 436

Query: 563  VAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAM---EEAVAQVLEQDQR--HLLESKQEK 617
            +       V       + V  PE   E  LK +    E + +VLE  QR    L  ++ +
Sbjct: 437  LRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERE 496

Query: 618  MQQLREKLCQE---EEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLR 674
            +  L+  L +E    ++E+  + QQ ++    LR  +Q A ++    + E E Q++S L 
Sbjct: 497  LTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHA--VLEAERQKMSALV 554

Query: 675  AQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIEASEK 734
              +Q   +   ++     ++  QK +E+L +  K E   L  +  +M E+L E+IE  ++
Sbjct: 555  RGLQRELEETSEET-GHWQSMFQKNKEDLRAT-KQELLQLRMEKEEMEEELGEKIEVLQR 612

Query: 735  S-EQAALNAAKEKALQQLREQL---EGERKEAVATLEKEHSA------ELERLCSSLEA- 783
              EQA  +A   + ++ L+++L   + E KE  A  + +  A      ELE+  + L   
Sbjct: 613  ELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVE 672

Query: 784  --KHREVVSS---LQKKIQEAQQK-EEAQLQKCLGQVEHRV------------------- 818
              + RE+      LQK +Q+ +Q  EEA   K + + E  V                   
Sbjct: 673  ADRGRELEEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEEN 732

Query: 819  HQKSYHVAGYEHELSSL-------------LREKRQEVEGEHERRLDKMK--EEHQQVMA 863
             +    + G E +L                LR+K Q +E E ++  + +   +E +  +A
Sbjct: 733  DEFRRRILGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLA 792

Query: 864  KAREQYEAE-ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQER 922
             A+   EA  E  QR   L  L  E + L RA E E +  R+   +   +L  + R  +R
Sbjct: 793  AAKRALEARLEEAQRG--LARLGQEQQTLNRALEEEGKQ-REVLRRGKAELEEQKRLLDR 849

Query: 923  KLQDLELDLETRAKDVKARLALLEVQ----EETARREKQQLLDVQRQVALKSEEATATHQ 978
             +  L  +LE   +D K  L  L+ Q    +E ARRE   + D QRQ    + EA  T  
Sbjct: 850  TVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKARRE---VADAQRQAKDWASEAEKTSG 906

Query: 979  QLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK 1038
             L   Q E        Q+LR+ L   QA +       +LL  + Q L++   + +     
Sbjct: 907  GLSRLQDE-------IQRLRQALQASQAERDTARLDKELLAQRLQGLEQEAENKKRSQDD 959

Query: 1039 KQHLLREVTVEENNASPHFEPDLHIEDL---RKSLGTNQTKEVSSSLSQ---SKEDLYLD 1092
            +   L+ +  + +      + + +  +L   R + G +Q  ++ + L Q   +++DL  D
Sbjct: 960  RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQLRTELMQERSARQDLECD 1019

Query: 1093 SLSSHN-----VWHLLSAEGV--------ALRSAKEFLVQQTRSMRRRQTALKAAQQHWR 1139
             +S           L S+EG          L S  + L ++ ++  R +T L++  +   
Sbjct: 1020 KISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQERLQAEEREKTVLQSTNRKLE 1079

Query: 1140 HELASAQEVAKDPP------------GIKALEDMRKNLEKETRHLDEM-KSAMR---KGH 1183
             ++       +D               +KAL+      E+E   LD + K A R   + H
Sbjct: 1080 RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREVEEQH 1139

Query: 1184 NLLKKKEEKLNQLESSLWEEAS---DEGTLGGSPTKKAVTFD-LSDMDSLSSESSES 1236
             + ++ + ++  LE   W +AS    E  L          FD + D  S++S  +ES
Sbjct: 1140 EVNEQLQARIKSLEKDSWRKASRSAAESALKNEGLSSDEEFDSVYDPSSIASLLTES 1196



 Score = 57.8 bits (138), Expect = 8e-08
 Identities = 144/627 (22%), Positives = 243/627 (38%), Gaps = 110/627 (17%)

Query: 505  KEAEELGEDSAASLSLQLS----LQREQAPSP---------PAACEKGK--EQHSQAEEL 549
            K A + G   A S  L+L      Q +  P+P         P A   GK    HSQA   
Sbjct: 83   KGANDQGASGALSSDLELPENPYSQVKGFPAPSQSSTSDEEPGAYWNGKLLRSHSQASLA 142

Query: 550  GPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH 609
            GPG  +  +    +       ++P+V S     P   +  A L +++  + +   Q    
Sbjct: 143  GPGPVDPSNRSNSML-----ELAPKVAS-----PGSTIDTAPLSSVDSLINKFDSQ---- 188

Query: 610  LLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQR 669
             L  +       R ++   E+       +++ +SL S   RL +   EE    RE +S  
Sbjct: 189  -LGGQARGRTGRRTRMLPPEQ-------RKRSKSLDS---RLPRDTFEE----RERQSTN 233

Query: 670  LSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEI 729
              W      SST+ D     ++Q A  Q L             S   ++RQ  + + +  
Sbjct: 234  -HWT-----SSTKYDNHVGTSKQPAQSQNLSP----------LSGFSRSRQTQDWVLQSF 277

Query: 730  EASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVV 789
            E   +S Q       +     LR+Q E     +V  ++      L    S  E   R  V
Sbjct: 278  EEPRRSAQDPTMLQFKSTPDLLRDQQEAAPPGSVDHMKATIYGILREGSSESETSVRRKV 337

Query: 790  SSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEH-- 847
            S + +K+Q          +   GQ E      +  V   + +L   ++ KRQ++E     
Sbjct: 338  SLVLEKMQPLVMVSSGSTKAVAGQGE-----LTRKVEELQRKLDEEVK-KRQKLEPSQVG 391

Query: 848  -ERRLDKMKEEHQQVM-AKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQE 905
             ER+L++  EE  ++     R + EA++  +  + +  L  + E L+      LET   E
Sbjct: 392  LERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQGEDLRHG----LETQVME 447

Query: 906  QHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQ 965
               +L+ ++     +E  L+DL   LETR         L EV E   R E+Q  L  +  
Sbjct: 448  LQNKLKHVQGPEPAKEVLLKDL---LETRE-------LLEEVLEGKQRVEEQLRLREREL 497

Query: 966  VALK---SEEATATHQQLEEAQKEHTHLLQSNQQLREILDE-------LQARKLKLESQV 1015
             ALK    EE  +  Q++E  ++++    +  +QLR  + +       L+A + K+ + V
Sbjct: 498  TALKGALKEEVASRDQEVEHVRQQYQ---RDTEQLRRSMQDATQDHAVLEAERQKMSALV 554

Query: 1016 DLLQAQSQQ-----------LQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEP-DLHI 1063
              LQ + ++            QK+   L A  Q+   L  E    E       E     +
Sbjct: 555  RGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEELGEKIEVLQREL 614

Query: 1064 EDLRKSLG-TNQTKEVSSSLSQSKEDL 1089
            E  R S G T Q + +   L +++E+L
Sbjct: 615  EQARASAGDTRQVEVLKKELLRTQEEL 641



 Score = 36.2 bits (82), Expect = 0.24
 Identities = 55/302 (18%), Positives = 124/302 (41%), Gaps = 20/302 (6%)

Query: 946  EVQEETARREKQQLLDV--QRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDE 1003
            ++ EE  +R+K +   V  +RQ+  K+EE +   + LE  + E     +  Q ++ +LD+
Sbjct: 374  KLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGEAQQSNKELQNMKRLLDQ 433

Query: 1004 LQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHI 1063
             +  +  LE+QV        +LQ     ++     K+ LL+++           E    +
Sbjct: 434  GEDLRHGLETQV-------MELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRV 486

Query: 1064 EDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRS 1123
            E+  +     + +E+++     KE++        +V      +   LR + +   Q    
Sbjct: 487  EEQLRL----RERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAV 542

Query: 1124 MRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGH 1183
            +   +  + A  +  + EL   +E +++    +++   +KN E       E+     +  
Sbjct: 543  LEAERQKMSALVRGLQREL---EETSEETGHWQSM--FQKNKEDLRATKQELLQLRMEKE 597

Query: 1184 NLLKKKEEKLNQLESSLWEEASDEG-TLGGSPTKKAVTFDLSDMDSLSSE-SSESFSPPH 1241
             + ++  EK+  L+  L +  +  G T      KK +     ++  L +E  S+  +  H
Sbjct: 598  EMEEELGEKIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRH 657

Query: 1242 RE 1243
            R+
Sbjct: 658  RD 659


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score =  117 bits (292), Expect = 1e-25
 Identities = 203/977 (20%), Positives = 409/977 (41%), Gaps = 127/977 (12%)

Query: 344  EKEAPEDTV-DAGEEGSRREEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIA 402
            EK A E+ V +  EE +  EE   +  K+  +L+E       +L++    +E +++  I 
Sbjct: 971  EKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQV----EEDKVNGLIK 1026

Query: 403  SDPKSFHGLDFGFRSRISEHLL--DVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ 460
             + K     D    S   E  L  D++     L G  + +Q+ + ++ ++D Q  +++L+
Sbjct: 1027 INAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESI-MDLENDKQQIEEKLK 1085

Query: 461  SKQSK--GLEERLSPPLPHEERAQSPPRSL-ATEEEPPQGPEGQPEWKEAEELGEDSAAS 517
             K+ +   L+ ++     H  + Q   + L A  EE  +  E +   +   E      A 
Sbjct: 1086 KKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLAR 1145

Query: 518  LSLQLSLQREQAPSPPAA-CEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVR 576
               ++S + E+A    +A  E  K++ ++ +++    EEA    E  A +     +  V 
Sbjct: 1146 ELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVA 1205

Query: 577  ST-EPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILR 635
               E +   +++ +   K   E   ++   D    +E+  +    + E+ C+  E++   
Sbjct: 1206 ELGEQIDNLQRVKQKLEKEKSELKMEI--DDMASNIEALSKSKSNI-ERTCRTVEDQFSE 1262

Query: 636  LHQQKEQS------LSSLRERLQKAIEEEEARMREEES-------------QRLSWLRAQ 676
            +  + EQ       L+  + RLQ    E   R+ E+ES             Q+L  L+ Q
Sbjct: 1263 IKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQ 1322

Query: 677  VQSSTQADEDQIRAEQEA--SLQKLREELESQQKAE---RASLEQKNRQMLE-------- 723
            ++  T+A      A Q +      LRE+ E +Q+A+   + +L + N ++ +        
Sbjct: 1323 MEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETD 1382

Query: 724  --QLKEEIEASEKSEQAALNAAKEK---------ALQQLREQLEGERKEAVATLEKEHSA 772
              Q  EE+E ++K     L  A+E          +L++ +++L+GE ++ +  LE+ H+A
Sbjct: 1383 AIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTA 1442

Query: 773  ELERLCSSLEAKHR---EVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYE 829
                 C++L+ K R   +V++  ++K+ E+Q + EA  QK    +   + +         
Sbjct: 1443 -----CATLDKKQRNFDKVLAEWKQKLDESQAELEAA-QKESRSLSTELFKMRNAYEEVV 1496

Query: 830  HELSSLLREKR---QEVEGEHERRLDKMKE-EHQQVMAKAREQYEAEERKQRAELLGHLT 885
             +L +L RE +   +E+    E+  +  K  +  +   K  EQ +++ +    E+ G L 
Sbjct: 1497 DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556

Query: 886  GELERLQRAHERELETVRQEQHKRL----EDLRRRHREQERKLQDLELDLETRAKDVKAR 941
             E  ++ R  + EL  V+ E  +++    E++ +  R  +R  + L+  L+   +     
Sbjct: 1557 HEESKILRV-QLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDA 1615

Query: 942  LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLRE-- 999
            L L +  E      + QL    RQ+A   +       QL+++Q      L+SN+ L+E  
Sbjct: 1616 LRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQL 1675

Query: 1000 ---------ILDELQARKLKLE-----------------SQVDLLQAQSQQLQKHFSSLE 1033
                     +L+EL+  K+ LE                  +V LL +Q+  L      LE
Sbjct: 1676 AIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLE 1735

Query: 1034 AEAQKKQHLLREVTVEENNASPH-----FEPDLHIEDLRKSLGTN-QTKEVSSSLSQSKE 1087
            A+  + Q  +     E  NA         +  +  E+L+K   T+   + +  +L Q+ +
Sbjct: 1736 ADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795

Query: 1088 DLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQTALKAAQQHWRHELASAQE 1147
            DL            L  AE +AL+  K+ + +    +R  +  L   Q+     L  A +
Sbjct: 1796 DLQ---------HRLDEAEQLALKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHK 1846

Query: 1148 VAKDPPGIK-ALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSL------ 1200
              +    +    E+  KN+ +    +D++++ ++      ++ EE+ N   S        
Sbjct: 1847 YERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE 1906

Query: 1201 WEEASDEGTLGGSPTKK 1217
             EEA++   +  S   K
Sbjct: 1907 LEEAAERADIAESQVNK 1923



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 177/878 (20%), Positives = 358/878 (40%), Gaps = 140/878 (15%)

Query: 99   ERAKLSTSGAIKKKKKKKEKKDKKDRDPPKSSLALGSSLAPVHVPLGGLAPLRGLVDTPP 158
            E A  +TS  I+  KK++ +  K  RD  +++L   ++ A                    
Sbjct: 1155 EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAA-------------------- 1194

Query: 159  SALRGSQSVSLGSSVESGRQLGELMLPSQGL-KTSAYTKGLLGSIYEDKTALSLLGLGEE 217
              LR  Q+ S+    E G Q+  L    Q L K  +  K  +  +  +  ALS      E
Sbjct: 1195 -TLRKKQADSVA---ELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250

Query: 218  TN---EEDE-------EESDNQSVHSSSEPLRNLHLDIGALGGDFEYEESLRTSQPEEKK 267
                  ED+       +E   Q +H  +     L    G L    E +ESL +   + K+
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310

Query: 268  DVSLDSDAAGPPTPCKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKICRNL 327
             ++   +               ++   +A+    Q S     L  ++  E+ E K     
Sbjct: 1311 ALTQQLEEL-------KRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQR 1363

Query: 328  VTPKADPTGSEPAKASEKEA---PEDTVDAGEEGSRREEAAKEPKKKASALEEGSSDASQ 384
               KA+   ++     E +A    E+  +A ++ ++R + A+E  + A++         Q
Sbjct: 1364 ALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQ 1423

Query: 385  EL--EISEHMKEPQLSDSIASD----PKSFHGLDFGFRSRISEHLLDVDVLSPVLGGACR 438
             L  E+ + M++ + S +  +      ++F  +   ++ ++ E   +++        A +
Sbjct: 1424 RLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELE--------AAQ 1475

Query: 439  QAQQPLGIE---DKDDSQSSQDELQS--KQSKGLEERLSPPLPHEERAQSPPRSLATEEE 493
            +  + L  E    ++  +   D+L++  +++K L+E +S      E+     ++L   E+
Sbjct: 1476 KESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLT---EQIAETGKNLQEAEK 1532

Query: 494  PPQGPEG-----QPEWKEAE-ELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAE 547
              +  E      Q   +E E  L  + +  L +QL L + ++       EK +E     E
Sbjct: 1533 TKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDEE----IE 1588

Query: 548  ELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVA---QVLE 604
            +L    + A +  + V       +  E+RS       ++  E  L  ME  +    + + 
Sbjct: 1589 QLKRNSQRAAEALQSV-------LDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMA 1641

Query: 605  QDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEE-EEARMR 663
            + Q+HL      +  Q + K  Q   ++ LR ++  ++ L+ +  R    +EE EE ++ 
Sbjct: 1642 ETQKHL------RTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVA 1695

Query: 664  EEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLE 723
             E+++R   L  Q +    +D  Q+   Q  SL   +++LE       A + Q   ++  
Sbjct: 1696 LEQTERTRRLSEQ-ELLDASDRVQLLHSQNTSLINTKKKLE-------ADIAQCQAEVEN 1747

Query: 724  QLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEA 783
             ++E   A EK+++A  +AA       + E+L+ E+         + SA LER+  +LE 
Sbjct: 1748 SIQESRNAEEKAKKAITDAA------MMAEELKKEQ---------DTSAHLERMKKNLE- 1791

Query: 784  KHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEV 843
               + V  LQ ++ EA+Q      +K + ++E+RV                  RE   E+
Sbjct: 1792 ---QTVKDLQHRLDEAEQLALKGGKKQIQKLENRV------------------RELENEL 1830

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
            + E +R  + +K  H+         Y+AEE  +    L  L  +L+   ++++R+ E   
Sbjct: 1831 DVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAE 1890

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKAR 941
            ++ + +L   RR   E E   +  ++  E++   ++A+
Sbjct: 1891 EQANTQLSRCRRVQHELEEAAERADI-AESQVNKLRAK 1927



 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 143/604 (23%), Positives = 259/604 (42%), Gaps = 83/604 (13%)

Query: 451  DSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEEL 510
            D+    +EL+  + K L +RL     + E A S   SL   ++  QG        E E+L
Sbjct: 1382 DAIQRTEELEEAKKK-LAQRLQEAEENTETANSKCASLEKTKQRLQG--------EVEDL 1432

Query: 511  GEDSAASLSLQLSLQREQAPSPPAACE-KGKEQHSQAEELGPGQEEAEDP---------- 559
              D   S +   +L ++Q        E K K   SQAE L   Q+E+             
Sbjct: 1433 MRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAE-LEAAQKESRSLSTELFKMRNA 1491

Query: 560  -EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAME-EAVAQVLEQDQRHLLESKQEK 617
             EE V    T     +    E     EQ++E      E E   +++EQ++  L  + +E 
Sbjct: 1492 YEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEV 1551

Query: 618  MQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQV 677
               L     + EE +ILR+  +  Q  S L  ++ +  ++EE    +  SQR +     +
Sbjct: 1552 EGSL-----EHEESKILRVQLELSQVKSELDRKVIE--KDEEIEQLKRNSQRAA---EAL 1601

Query: 678  QSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE--EIEASEKS 735
            QS   A+   IR+  +A   +L++++E         L   NRQM E  K    ++   K 
Sbjct: 1602 QSVLDAE---IRSRNDAL--RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKD 1656

Query: 736  EQAALNAAKEKALQQLREQLEGERKEAVATLEK--------EHSAELERLCSS--LEAKH 785
             Q  L+ A  ++ + L+EQL    +     LE+        E +    RL     L+A  
Sbjct: 1657 SQLHLDDAL-RSNEDLKEQLAIVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASD 1715

Query: 786  R-EVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQ-KSYHVAGYEHELSSLLREKRQEV 843
            R +++ S    +   ++K EA + +C  +VE+ + + ++      +    + +  +  + 
Sbjct: 1716 RVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775

Query: 844  EGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQRAHER--ELET 901
            E +    L++MK+  +Q +     Q+  +E +Q A     L G  +++Q+   R  ELE 
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDL--QHRLDEAEQLA-----LKGGKKQIQKLENRVRELEN 1828

Query: 902  VRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLD 961
                + KR  +  +   + ERK++++    E   K++  RL              Q L+D
Sbjct: 1829 ELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNI-LRL--------------QDLVD 1873

Query: 962  VQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
             + Q  +KS +     +Q EEA+++    L   ++++  L+E   R    ESQV+ L+A+
Sbjct: 1874 -KLQAKVKSYK-----RQAEEAEEQANTQLSRCRRVQHELEEAAERADIAESQVNKLRAK 1927

Query: 1022 SQQL 1025
            S+ +
Sbjct: 1928 SRDV 1931



 Score = 54.3 bits (129), Expect = 8e-07
 Identities = 98/461 (21%), Positives = 187/461 (40%), Gaps = 87/461 (18%)

Query: 846  EHERRLDKMKEEHQQVM-----AKAREQYEAEER-----KQRAELLGHLTGELERLQRAH 895
            E E+ +  MKE+ ++       ++AR + E EE+     +++ +L   +  E E L  A 
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRK-ELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906

Query: 896  ERELETVRQE--QHKRLEDLRRRHREQERKLQDL---ELDLETRAKDVKARLALLEVQEE 950
            ER    ++ +     ++++L  R  E+E    +L   + +LE +   +K  +  LE+   
Sbjct: 907  ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT 966

Query: 951  TARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARK-- 1008
               +EK      + +V   SEE TA  + + +  KE   L +++QQ    LD+LQ  +  
Sbjct: 967  KVEKEKHA---TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQT---LDDLQVEEDK 1020

Query: 1009 --------LKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQ---HLLREVTVEENNASPHF 1057
                     KLE Q D L+   +Q +K  + LE   +K +    + +E  ++  N     
Sbjct: 1021 VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQI 1080

Query: 1058 EPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFL 1117
            E     E L+K       KE   S  Q+K    +D    H+                   
Sbjct: 1081 E-----EKLKK-------KEFELSQLQAK----IDDEQVHS------------------- 1105

Query: 1118 VQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKS 1177
            +Q  + ++  Q  ++  ++    E     ++ K         D+ + LE+ +  L+E   
Sbjct: 1106 LQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQ------RSDLARELEEISERLEEASG 1159

Query: 1178 AMRKGHNLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKKAVTFDLSDMDSLSSESSESF 1237
            A      + KK+E +  ++   L     +E TL    T  A T      DS+ +E  E  
Sbjct: 1160 ATSAQIEMNKKREAEFQKMRRDL-----EEATLQHEAT--AATLRKKQADSV-AELGEQI 1211

Query: 1238 SPPHREWWRQQRIDSTPSLTSRKIHGLSHSLRQISSQLSSV 1278
                R    +Q+++   S    +I  ++ ++  +S   S++
Sbjct: 1212 DNLQRV---KQKLEKEKSELKMEIDDMASNIEALSKSKSNI 1249


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score =  115 bits (288), Expect = 3e-25
 Identities = 220/984 (22%), Positives = 401/984 (40%), Gaps = 173/984 (17%)

Query: 315  ENEKSEPKICRNLVTPKADPTGSEPAKASEKEAP--------EDTVDAGEEGSRREEAAK 366
            E++ S+    R L+  +     S+ A+  EK           E T+   E+  R+EE  +
Sbjct: 1016 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1075

Query: 367  EPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGL------DFGFRSRIS 420
            +  +K     +G S   QE  + +  +  +L   +    +           + G R+++ 
Sbjct: 1076 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1135

Query: 421  EHLLDVDVL----------SPVLGGACRQAQQPLG---------IEDKDDSQSSQDELQS 461
            + L +                V      + ++ LG         +ED  DS ++Q EL+S
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195

Query: 462  KQS-------KGLEE--RLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAE---- 508
            K+        K LEE  R+      E R +         E+  Q   G+  W++      
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255

Query: 509  -ELGEDSAASLSLQ------------LSLQREQAPSPPAACEKGKEQHSQAEELGPGQEE 555
             E+ E  A   SLQ            L LQ ++        E+ + +   AE+L   Q E
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE--AAEKLQRAQAE 1313

Query: 556  AEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLES 613
             E+    +  A S T  +S E+ STE      QL +A     EE  A++    +   +E+
Sbjct: 1314 LENVSGALNEAESKTIRLSKELSSTEA-----QLHDAQELLQEETRAKLALGSRVRAMEA 1368

Query: 614  KQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWL 673
            +      LRE+L +EE     R  ++ + + + L E  ++  EE  A    EE++R +  
Sbjct: 1369 EAAG---LREQL-EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1424

Query: 674  RAQVQSSTQADEDQIRAEQEASLQKLREELES------QQKAERASLEQKNRQMLEQLKE 727
             A+  +   A++ +     E   ++L++EL+       QQ+   ++LE+K R+  + L E
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484

Query: 728  EIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVA-----TLEKEHSA--ELERLCSS 780
            E       + A L A +E+     R + EG  +EA A      LE+E  A  ELER   +
Sbjct: 1485 E-------KAAVLRAVEERE----RAEAEGREREARALSLTRALEEEQEAREELERQNRA 1533

Query: 781  LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL----- 835
            L A+   ++SS     ++   K   +L++     E   +     V   E EL++      
Sbjct: 1534 LRAELEALLSS-----KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL 1588

Query: 836  -LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQRAELLG---HLT 885
             L    Q ++ +HER L   D+  EE ++ +AK     E E   ERKQR   +     L 
Sbjct: 1589 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1648

Query: 886  GELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945
            GELE L+     ++ +  Q + + ++ LR+   + +   +++E   ETR     +R  + 
Sbjct: 1649 GELEELKA----QMASAGQGKEEAVKQLRKMQAQMKELWREVE---ETRT----SREEIF 1697

Query: 946  EVQEETARREK---QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILD 1002
                E+ +R K    ++L +Q ++A          Q  +E   E  +   S   + E   
Sbjct: 1698 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1757

Query: 1003 ELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK-KQHLLREVTVEENNASPHFEPDL 1061
            +L+ R  +LE +++  Q+ S+ L   +  L  + +     L  E +      S   + + 
Sbjct: 1758 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1817

Query: 1062 HIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQT 1121
             I++LR  LG           ++++  + + +L S             L  A+E L Q+T
Sbjct: 1818 QIQELRGRLGEEDAG------ARARHKMTIAALESK------------LAQAEEQLEQET 1859

Query: 1122 RSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRK 1181
            R        ++ A+                    K L+++   +E+E R  D+++  + K
Sbjct: 1860 RERILSGKLVRRAE--------------------KRLKEVVLQVEEERRVADQLRDQLEK 1899

Query: 1182 GHNLLKKKEEKLNQLESSLWEEAS 1205
            G+  +K+ + +L + E    EEAS
Sbjct: 1900 GNLRVKQLKRQLEEAE----EEAS 1919



 Score =  111 bits (278), Expect = 4e-24
 Identities = 210/946 (22%), Positives = 383/946 (40%), Gaps = 116/946 (12%)

Query: 315  ENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDA--GEEGSRREEAAKEPKKKA 372
            E  ++E ++C        +  G   A+  E E     ++A  GEE    EE +++ + + 
Sbjct: 919  EQLRAEAELCAEA----EETRGRLAARKQELELVVSELEARVGEE----EECSRQMQTEK 970

Query: 373  SALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPV 432
              L++   +    LE  E  ++    + + ++ K           +  E LL ++  +  
Sbjct: 971  KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKM---------KKFEEDLLLLEDQNSK 1021

Query: 433  LGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEE 492
            L      +++   +ED+    SSQ   + ++ K L +     L +E         L  EE
Sbjct: 1022 L------SKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR---LKYEATIADMEDRLRKEE 1072

Query: 493  EPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPG 552
            +      G+ E ++ +   +  ++ L  Q+  Q+++A    A  + G+++    EEL   
Sbjct: 1073 K------GRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA--QLGRKE----EELQAA 1120

Query: 553  QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE 612
               AED     A      +   +R  +       L+EA      E VA+   + QR  L 
Sbjct: 1121 LARAEDEGGARA-----QLLKSLREAQAA-----LAEAQEDLESERVARTKAEKQRRDLG 1170

Query: 613  SKQEKMQ-QLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA---RMREEESQ 668
             + E ++ +L + L     ++ LR   ++EQ ++ L++ L++     EA    +R+   Q
Sbjct: 1171 EELEALRGELEDTLDSTNAQQELR--SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQ 1228

Query: 669  RLSWLRAQVQSSTQADE--DQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLK 726
             L  L  Q++ + +     ++ R   EA + +LR EL S Q A +   EQ+ R++  QL+
Sbjct: 1229 ALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEG-EQRRRRLELQLQ 1287

Query: 727  E-----------EIEASEKSEQA---------ALNAAKEKALQQLRE--QLEGERKEAVA 764
            E             EA+EK ++A         ALN A+ K ++  +E    E +  +A  
Sbjct: 1288 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1347

Query: 765  TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEA--QLQKCLGQVEHRVHQKS 822
             L++E  A+L  L S + A   E     ++  +EA  +E A  +LQ    Q+     ++ 
Sbjct: 1348 LLQEETRAKLA-LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW-RRRQ 1405

Query: 823  YHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLG 882
               AG         R   +E E   +R  +K +   +    + R Q E ++     E   
Sbjct: 1406 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1465

Query: 883  HLTGELERLQRAHERELETVRQEQHKRLEDLRRRHRE-QERKLQDLELDLETRAKDVKAR 941
             L   LE+ QR  ++ L   +    + +E+  R   E +ER+ + L L   TRA + +  
Sbjct: 1466 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL---TRALEEEQ- 1521

Query: 942  LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREIL 1001
                E +EE  R+ +    +++  ++ K +   + H+     +           Q+ E+ 
Sbjct: 1522 ----EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1577

Query: 1002 DELQAR---KLKLESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            DEL A    KL+LE  V  L+ Q ++ LQ    + E   ++    LR+  VE +      
Sbjct: 1578 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK-- 1635

Query: 1058 EPDLHIEDLRKSLGT-NQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEF 1116
            +  L +   +K  G   + K   +S  Q KE+              L  E    R+++E 
Sbjct: 1636 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1695

Query: 1117 LVQQTRSMRRRQTALKAAQQHWRHELAS---------------AQEVAKDPPGIKALEDM 1161
            +  Q R   +R   L+A     + ELA+               A EVA       A+ + 
Sbjct: 1696 IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE 1755

Query: 1162 RKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE 1207
            ++ LE     L+E     +    LL  +  KL     SL  E S E
Sbjct: 1756 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1801



 Score =  109 bits (272), Expect = 2e-23
 Identities = 172/694 (24%), Positives = 304/694 (43%), Gaps = 112/694 (16%)

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESK--QEKMQQLREKLCQEEE--------------- 630
            +EA +K  EE +  + +Q+ +   E K  ++++ +   +  +EEE               
Sbjct: 1001 TEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1060

Query: 631  ----EEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQV---QSSTQA 683
                E+ LR  ++  Q L  L+ RL     E + +M E++ QR   LRAQ+   +   QA
Sbjct: 1061 IADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQ-QRAEELRAQLGRKEEELQA 1119

Query: 684  ------DEDQIRA-------EQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIE 730
                  DE   RA       E +A+L + +E+LES++ A R   E++ R     L EE+E
Sbjct: 1120 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA-RTKAEKQRR----DLGEELE 1174

Query: 731  ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVS 790
            A     +  L++    A Q+LR + E E  E   TLE+E     E     L  +H + + 
Sbjct: 1175 ALRGELEDTLDST--NAQQELRSKREQEVTELKKTLEEETRIH-EAAVQELRQRHGQALG 1231

Query: 791  SLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERR 850
             L +++++A++ +        G  E         V+    ELSSL   ++   EGE  RR
Sbjct: 1232 ELAEQLEQARRGK--------GAWEKTRLALEAEVSELRAELSSLQTARQ---EGEQRRR 1280

Query: 851  LDKMKEEHQQVMAKA----REQYEAEERKQRAELLGHLTGELERLQRA-HERELETVRQE 905
              +++ + Q+V  +A    R + EA E+ QRA+       ELE +  A +E E +T+R  
Sbjct: 1281 --RLELQLQEVQGRAGDGERARAEAAEKLQRAQ------AELENVSGALNEAESKTIRLS 1332

Query: 906  QHKRLEDLRRRHREQERKLQD-----LELDLETRAKDVKARLALLEVQEETARREK--QQ 958
              K L     +  + +  LQ+     L L    RA + +A     +++EE A RE+  ++
Sbjct: 1333 --KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1390

Query: 959  LLDVQRQVA---LKSEEATATHQQLEEAQ----KEHTHLLQSNQQLREILDELQARKLKL 1011
            L   Q Q++    + EE     +  EEA+    +E   L Q   +  E +D L+  + +L
Sbjct: 1391 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1450

Query: 1012 ESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLG 1071
            + ++D      +Q ++  S+LE + +K   LL E       A         +E+  ++  
Sbjct: 1451 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA---------VEERERAEA 1501

Query: 1072 TNQTKE---VSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQ 1128
              + +E   +S + +  +E    + L   N    L AE  AL S+K+ + +    + R  
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQN--RALRAELEALLSSKDDVGKSVHELER-- 1557

Query: 1129 TALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLE-----KETRHLDEMKSAMRKGH 1183
             A + A+Q      A   E+  +   + A ED +  LE      +T+H  +++     G 
Sbjct: 1558 -ACRVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1613

Query: 1184 NLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKK 1217
               ++  ++L   E    EE   + TL  +  KK
Sbjct: 1614 ERRRQLAKQLRDAEVERDEERK-QRTLAVAARKK 1646



 Score =  103 bits (257), Expect = 1e-21
 Identities = 188/836 (22%), Positives = 351/836 (41%), Gaps = 134/836 (16%)

Query: 306  ARPGLPEKEENEKSEPKICRNLVTPKADPTGSE-PAKASEKEAPEDTVDAGEE-GSRREE 363
            A+  L E +E+ +SE ++ R     +    G E  A   E E   D+ +A +E  S+RE+
Sbjct: 1141 AQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQ 1199

Query: 364  AAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPK---SFHGLDFGFRSRIS 420
               E KK           A QEL         +L++ +    +   ++        + +S
Sbjct: 1200 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1259

Query: 421  EHLLDVDVLSPVLG-GACRQAQQPLGIED---------------KDDSQSSQDELQS--- 461
            E   ++  L      G  R+ +  L +++                +  Q +Q EL++   
Sbjct: 1260 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1319

Query: 462  --KQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQ---GPEGQPEWKEA----EELGE 512
               +++    RLS  L   E      + L  EE   +   G   +    EA    E+L E
Sbjct: 1320 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE 1379

Query: 513  DSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVS 572
            ++AA       LQ  QA       +  + +  Q EE G   E  E+   + A        
Sbjct: 1380 EAAARERAGRELQTAQA-------QLSEWRRRQEEEAG-ALEAGEEARRRAAREAEALTQ 1431

Query: 573  PEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEE 632
                 TE V   ++L     +  +E     ++ +Q+  L S  EK Q+  ++L  EE+  
Sbjct: 1432 RLAEKTETV---DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAA 1488

Query: 633  ILRLHQQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS--STQAD- 684
            +LR  +++E++ +  RER  +A+      EEE   REE  ++   LRA++++  S++ D 
Sbjct: 1489 VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1548

Query: 685  ----------------------------EDQIRAEQEASL------QKLREELESQQKAE 710
                                        ED++ A ++A L      Q L+ + E   +  
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608

Query: 711  RASLEQKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEA 762
              + E++ RQ+ +QL++ E+E  E+ +Q  L  A  K L+   E+L+ +       ++EA
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668

Query: 763  VATLEKEHS--AELERLCSSLEAKHREVVS---SLQKKIQ--EAQ----QKEEAQLQKCL 811
            V  L K  +   EL R          E+ S     +K+++  EA+    Q+E A   +  
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1728

Query: 812  GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA 871
             Q +    + +  VA      +++L EKRQ +EG    RL +++EE ++  + + E    
Sbjct: 1729 RQAQQDRDEMADEVANGNLSKAAILEEKRQ-LEG----RLGQLEEELEEEQSNS-ELLND 1782

Query: 872  EERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDL 931
              RK   + +  LT EL   +R+   + E+ RQ+  +++++LR R  E+         D 
Sbjct: 1783 RYRKLLLQ-VESLTTELS-AERSFSAKAESGRQQLERQIQELRGRLGEE---------DA 1831

Query: 932  ETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLL 991
              RA+  K  +A LE           +L   + Q+  ++ E   + + +  A+K    ++
Sbjct: 1832 GARARH-KMTIAALE----------SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVV 1880

Query: 992  QSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVT 1047
               ++ R + D+L+ +  K   +V  L+ Q ++ ++  S  +A  ++ Q  L +VT
Sbjct: 1881 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVT 1936



 Score =  101 bits (251), Expect = 6e-21
 Identities = 227/954 (23%), Positives = 402/954 (42%), Gaps = 162/954 (16%)

Query: 147  LAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLGELMLPSQGLKTSAYTKG-----LLGS 201
            L  L+  +D   S L+         + E   QLG      Q     A  +G     LL S
Sbjct: 1078 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKS 1137

Query: 202  IYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFE-------Y 254
            + E + AL+          +++ ES+  +   + +  R+L  ++ AL G+ E        
Sbjct: 1138 LREAQAALA--------EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 1189

Query: 255  EESLRTSQPEEKKDV--SLDSDAA---GPPTPCKPSSPGADSSLSSAVGKGRQGSGARPG 309
            ++ LR+ + +E  ++  +L+ +           +     A   L+  + + R+G GA   
Sbjct: 1190 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEK 1249

Query: 310  LPEKEENEKSEPKI-CRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEP 368
                 E E SE +    +L T + +  G +  +  E +  E    AG+    R EAA E 
Sbjct: 1250 TRLALEAEVSELRAELSSLQTARQE--GEQRRRRLELQLQEVQGRAGDGERARAEAA-EK 1306

Query: 369  KKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDV 428
             ++A A  E  S A  E E     K  +LS  ++S     H          ++ LL  + 
Sbjct: 1307 LQRAQAELENVSGALNEAE----SKTIRLSKELSSTEAQLHD---------AQELLQEET 1353

Query: 429  LSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
                      +A+  LG         S+      ++ GL E+L       ERA    R L
Sbjct: 1354 ----------RAKLALG---------SRVRAMEAEAAGLREQLEEEAAARERAG---REL 1391

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEE 548
             T +          EW+  +E   + A +L      +R  A    A  ++  E+    + 
Sbjct: 1392 QTAQAQLS------EWRRRQE---EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDR 1442

Query: 549  LGPG----QEEAEDP-----EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEE-- 597
            L  G    Q+E +D      +++  VS    +  + R  + +   E+   A L+A+EE  
Sbjct: 1443 LERGRRRLQQELDDATMDLEQQRQLVST---LEKKQRKFDQLLAEEKA--AVLRAVEERE 1497

Query: 598  -AVAQVLEQDQRHL-LESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAI 655
             A A+  E++ R L L    E+ Q+ RE+L  E +   LR   +   +L S ++ + K++
Sbjct: 1498 RAEAEGREREARALSLTRALEEEQEAREEL--ERQNRALRAELE---ALLSSKDDVGKSV 1552

Query: 656  EEEEARMREEESQRLSWLRAQV----QSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             E E   R  E Q  + LRAQV       T A++ ++R E      K + E + Q + E 
Sbjct: 1553 HELERACRVAE-QAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEA 1611

Query: 712  ASLEQKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAV 763
               E++ RQ+ +QL++ E+E  E+ +Q  L  A  K L+   E+L+ +       ++EAV
Sbjct: 1612 G--EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1669

Query: 764  ATLEKEHSA--ELERLCSSLEAKHREVVSS---LQKKIQ--EAQ----QKEEAQLQKCLG 812
              L K  +   EL R          E+ S     +K+++  EA+    Q+E A   +   
Sbjct: 1670 KQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARR 1729

Query: 813  QVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE 872
            Q +    + +  VA      +++L EKRQ +EG    RL +++EE ++  + + E     
Sbjct: 1730 QAQQDRDEMADEVANGNLSKAAILEEKRQ-LEG----RLGQLEEELEEEQSNS-ELLNDR 1783

Query: 873  ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ------------ 920
             RK   ++   LT EL   +R+   + E+ RQ+  +++++LR R  E+            
Sbjct: 1784 YRKLLLQVES-LTTELSA-ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1841

Query: 921  ---ERKLQDLE--LDLETRAKDVKARLA----------LLEVQEETARREKQQLLDVQRQ 965
               E KL   E  L+ ETR + +  +L           +L+V+EE  RR   QL D   +
Sbjct: 1842 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE--RRVADQLRDQLEK 1899

Query: 966  VALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQ 1019
              L+ ++     +QLEEA++E +      ++L+  L+++      +  +V  L+
Sbjct: 1900 GNLRVKQLK---RQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1950



 Score =  100 bits (249), Expect = 1e-20
 Identities = 160/674 (23%), Positives = 292/674 (43%), Gaps = 141/674 (20%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            QV  QD+  +L+++ +++Q+++E            L QQ  + +  L+ R+ + +EEE A
Sbjct: 871  QVTRQDE--VLQARAQELQKVQE------------LQQQSAREVGELQGRVAQ-LEEERA 915

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR-AEQEASLQKLREELESQ--QKAERASLEQK 717
            R+ E+       LRA+ +   +A+E + R A ++  L+ +  ELE++  ++ E +   Q 
Sbjct: 916  RLAEQ-------LRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 968

Query: 718  NRQMLEQLKEEIEASEKSEQAA---------LNAAKEK-------ALQQLREQLEGERK- 760
             ++ L+Q  +E+EA  ++E+ A            AK K        L+    +L  ERK 
Sbjct: 969  EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1028

Query: 761  --------EAVATLEKEHSAELERLCSSLEAKHREVVSSLQK---------KIQEAQQKE 803
                     + A  E+E    L +L    EA   ++   L+K         K++     E
Sbjct: 1029 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE 1088

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
             ++LQ+ + + + R  +    +   E EL + L   R E EG    +L K   E Q  +A
Sbjct: 1089 SSELQEQMVEQQQRAEELRAQLGRKEEELQAAL--ARAEDEGGARAQLLKSLREAQAALA 1146

Query: 864  KAREQYEAE---------ERKQRAELLGHLTGELE----------RLQRAHERELETVRQ 904
            +A+E  E+E         +R+   E L  L GELE           L+   E+E+  +++
Sbjct: 1147 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK 1206

Query: 905  --EQHKRL-----EDLRRRHREQERKLQDLELDLETRAKDV--KARLAL-LEVQE----- 949
              E+  R+     ++LR+RH +   +L + +L+   R K    K RLAL  EV E     
Sbjct: 1207 TLEEETRIHEAAVQELRQRHGQALGELAE-QLEQARRGKGAWEKTRLALEAEVSELRAEL 1265

Query: 950  ---ETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQA 1006
               +TAR+E +Q    +R++ L+ +E        E A+ E    LQ            QA
Sbjct: 1266 SSLQTARQEGEQR---RRRLELQLQEVQGRAGDGERARAEAAEKLQ----------RAQA 1312

Query: 1007 RKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDL 1066
                +   ++  ++++ +L K  SS EA+    Q LL+E T                   
Sbjct: 1313 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET-----------------RA 1355

Query: 1067 RKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRR 1126
            + +LG ++ + + +  +  +E L  ++ +           G  L++A+  L +  R    
Sbjct: 1356 KLALG-SRVRAMEAEAAGLREQLEEEAAARERA-------GRELQTAQAQLSEWRRRQEE 1407

Query: 1127 RQTALKAAQQHWRHELASA----QEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKG 1182
               AL+A ++  R     A    Q +A+    +  LE  R+ L++E           R+ 
Sbjct: 1408 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL 1467

Query: 1183 HNLLKKKEEKLNQL 1196
             + L+KK+ K +QL
Sbjct: 1468 VSTLEKKQRKFDQL 1481



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 120/541 (22%), Positives = 238/541 (43%), Gaps = 70/541 (12%)

Query: 697  QKLREELESQQKAERASLEQKNRQ---MLEQLKEEIEASEKSEQAALNAAKEKALQQLRE 753
            Q+ +  L   Q+   A L+ ++ Q   +  ++K  ++ + + E     A + + +Q+L++
Sbjct: 835  QQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQ 894

Query: 754  QLE---GERKEAVATLEKEHS-------------AELERLCSSLEAKHRE---VVSSLQK 794
            Q     GE +  VA LE+E +             AE E     L A+ +E   VVS L+ 
Sbjct: 895  QSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEA 954

Query: 795  KIQEAQ------QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEH- 847
            ++ E +      Q E+ +LQ+ + ++E   H ++   A  + +L  +  E + +   E  
Sbjct: 955  RVGEEEECSRQMQTEKKRLQQHIQELE--AHLEAEEGARQKLQLEKVTTEAKMKKFEEDL 1012

Query: 848  ---ERRLDKMKEEHQQVMAKARE-QYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
               E +  K+ +E + +  +  E   +A E +++ + L  L  + E      E  L    
Sbjct: 1013 LLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK-E 1071

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL--EVQEETARREKQQLLD 961
            ++  + LE L+RR   +  +LQ+  ++ + RA++++A+L     E+Q   AR E +    
Sbjct: 1072 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131

Query: 962  VQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
             Q   +L+  +A     Q E+ + E     ++ +Q R++ +EL+A + +LE  +D   AQ
Sbjct: 1132 AQLLKSLREAQAALAEAQ-EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1190

Query: 1022 SQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSS 1081
             Q+L+   S  E E  + +  L E T     A         +++LR+  G     E++  
Sbjct: 1191 -QELR---SKREQEVTELKKTLEEETRIHEAA---------VQELRQRHG-QALGELAEQ 1236

Query: 1082 LSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRS-MRRRQTALKAAQQHWRH 1140
            L Q++             W          R A E  V + R+ +   QTA +  +Q  R 
Sbjct: 1237 LEQARR--------GKGAWE-------KTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1281

Query: 1141 ELASAQEV-AKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESS 1199
                 QEV  +   G +A  +  + L++    L+ +  A+ +  +   +  ++L+  E+ 
Sbjct: 1282 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1341

Query: 1200 L 1200
            L
Sbjct: 1342 L 1342



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 76/334 (22%), Positives = 145/334 (43%), Gaps = 49/334 (14%)

Query: 890  RLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD--VKARLALLEV 947
            R  +  +++   +R  Q      L+ RH +  R    ++  L+   +D  ++AR   L+ 
Sbjct: 829  RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQK 888

Query: 948  QEETARREKQQLLDVQRQVALKSEEATATHQQLE-------EAQKEHTHLLQSNQQLREI 1000
             +E  ++  +++ ++Q +VA   EE     +QL        EA++    L    Q+L  +
Sbjct: 889  VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 948

Query: 1001 LDELQARKLKLESQVDLLQAQSQQLQKHFSSLEA-----EAQKKQHLLREVTVEENNASP 1055
            + EL+AR  + E     +Q + ++LQ+H   LEA     E  +++  L +VT E      
Sbjct: 949  VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK--MK 1006

Query: 1056 HFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKE 1115
             FE DL +            ++ +S LS+ ++ L  D L          AE  +  + +E
Sbjct: 1007 KFEEDLLL-----------LEDQNSKLSKERK-LLEDRL----------AEFSSQAAEEE 1044

Query: 1116 FLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDE- 1174
              V+    +R +  A  A  +           + K+  G + LE +++ L+ E+  L E 
Sbjct: 1045 EKVKSLNKLRLKYEATIADME---------DRLRKEEKGRQELEKLKRRLDGESSELQEQ 1095

Query: 1175 MKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEG 1208
            M    ++   L  +   K  +L+++L   A DEG
Sbjct: 1096 MVEQQQRAEELRAQLGRKEEELQAAL-ARAEDEG 1128



 Score = 37.7 bits (86), Expect = 0.082
 Identities = 97/431 (22%), Positives = 168/431 (38%), Gaps = 80/431 (18%)

Query: 333  DPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEE----------GSSDA 382
            D  G E  +   K+  +  V+  EE  +R  A    KK    LEE          G  +A
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1668

Query: 383  SQEL-EISEHMKE--PQLSDSIASDPKSFHGLDFGFRSRISEHLL---DVDVLSPVLGGA 436
             ++L ++   MKE   ++ ++  S  + F       ++R SE  L   + +VL       
Sbjct: 1669 VKQLRKMQAQMKELWREVEETRTSREEIFS------QNRESEKRLKGLEAEVL------- 1715

Query: 437  CRQAQQPLGIEDKDDSQSSQD--ELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEP 494
              + Q+ L   D+   Q+ QD  E+  + + G    LS     EE+ Q   R    EEE 
Sbjct: 1716 --RLQEELAASDRARRQAQQDRDEMADEVANG---NLSKAAILEEKRQLEGRLGQLEEE- 1769

Query: 495  PQGPEGQPEWKEAEELGEDSAASLSLQ---LSLQREQAPSPPAACEKGKEQ-HSQAEELG 550
                    E +   EL  D    L LQ   L+ +     S  A  E G++Q   Q +EL 
Sbjct: 1770 ------LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1823

Query: 551  PGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH- 609
             G+   ED   +                       +++ AAL++      + LEQ+ R  
Sbjct: 1824 -GRLGEEDAGARAR--------------------HKMTIAALESKLAQAEEQLEQETRER 1862

Query: 610  LLESK--QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
            +L  K  +   ++L+E + Q EEE          +    LR++L+K     +   R+ E 
Sbjct: 1863 ILSGKLVRRAEKRLKEVVLQVEEER---------RVADQLRDQLEKGNLRVKQLKRQLEE 1913

Query: 668  QRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE 727
                  RAQ        E +   E   S+ +    L ++ +    +   +  + + +L+E
Sbjct: 1914 AEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1973

Query: 728  EIEASEKSEQA 738
             + + E++E+A
Sbjct: 1974 GVASDEEAEEA 1984


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score =  115 bits (288), Expect = 3e-25
 Identities = 220/984 (22%), Positives = 401/984 (40%), Gaps = 173/984 (17%)

Query: 315  ENEKSEPKICRNLVTPKADPTGSEPAKASEKEAP--------EDTVDAGEEGSRREEAAK 366
            E++ S+    R L+  +     S+ A+  EK           E T+   E+  R+EE  +
Sbjct: 1008 EDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGR 1067

Query: 367  EPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGL------DFGFRSRIS 420
            +  +K     +G S   QE  + +  +  +L   +    +           + G R+++ 
Sbjct: 1068 QELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1127

Query: 421  EHLLDVDVL----------SPVLGGACRQAQQPLG---------IEDKDDSQSSQDELQS 461
            + L +                V      + ++ LG         +ED  DS ++Q EL+S
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187

Query: 462  KQS-------KGLEE--RLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAE---- 508
            K+        K LEE  R+      E R +         E+  Q   G+  W++      
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247

Query: 509  -ELGEDSAASLSLQ------------LSLQREQAPSPPAACEKGKEQHSQAEELGPGQEE 555
             E+ E  A   SLQ            L LQ ++        E+ + +   AE+L   Q E
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE--AAEKLQRAQAE 1305

Query: 556  AEDPEEKV--AVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLES 613
             E+    +  A S T  +S E+ STE      QL +A     EE  A++    +   +E+
Sbjct: 1306 LENVSGALNEAESKTIRLSKELSSTEA-----QLHDAQELLQEETRAKLALGSRVRAMEA 1360

Query: 614  KQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWL 673
            +      LRE+L +EE     R  ++ + + + L E  ++  EE  A    EE++R +  
Sbjct: 1361 EAAG---LREQL-EEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAR 1416

Query: 674  RAQVQSSTQADEDQIRAEQEASLQKLREELES------QQKAERASLEQKNRQMLEQLKE 727
             A+  +   A++ +     E   ++L++EL+       QQ+   ++LE+K R+  + L E
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476

Query: 728  EIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVA-----TLEKEHSA--ELERLCSS 780
            E       + A L A +E+     R + EG  +EA A      LE+E  A  ELER   +
Sbjct: 1477 E-------KAAVLRAVEERE----RAEAEGREREARALSLTRALEEEQEAREELERQNRA 1525

Query: 781  LEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSL----- 835
            L A+   ++SS     ++   K   +L++     E   +     V   E EL++      
Sbjct: 1526 LRAELEALLSS-----KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKL 1580

Query: 836  -LREKRQEVEGEHERRL---DKMKEEHQQVMAKAREQYEAE---ERKQRAELLG---HLT 885
             L    Q ++ +HER L   D+  EE ++ +AK     E E   ERKQR   +     L 
Sbjct: 1581 RLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLE 1640

Query: 886  GELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL 945
            GELE L+     ++ +  Q + + ++ LR+   + +   +++E   ETR     +R  + 
Sbjct: 1641 GELEELKA----QMASAGQGKEEAVKQLRKMQAQMKELWREVE---ETRT----SREEIF 1689

Query: 946  EVQEETARREK---QQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILD 1002
                E+ +R K    ++L +Q ++A          Q  +E   E  +   S   + E   
Sbjct: 1690 SQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKR 1749

Query: 1003 ELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQK-KQHLLREVTVEENNASPHFEPDL 1061
            +L+ R  +LE +++  Q+ S+ L   +  L  + +     L  E +      S   + + 
Sbjct: 1750 QLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLER 1809

Query: 1062 HIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQT 1121
             I++LR  LG           ++++  + + +L S             L  A+E L Q+T
Sbjct: 1810 QIQELRGRLGEEDAG------ARARHKMTIAALESK------------LAQAEEQLEQET 1851

Query: 1122 RSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRK 1181
            R        ++ A+                    K L+++   +E+E R  D+++  + K
Sbjct: 1852 RERILSGKLVRRAE--------------------KRLKEVVLQVEEERRVADQLRDQLEK 1891

Query: 1182 GHNLLKKKEEKLNQLESSLWEEAS 1205
            G+  +K+ + +L + E    EEAS
Sbjct: 1892 GNLRVKQLKRQLEEAE----EEAS 1911



 Score =  111 bits (278), Expect = 4e-24
 Identities = 210/946 (22%), Positives = 383/946 (40%), Gaps = 116/946 (12%)

Query: 315  ENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDA--GEEGSRREEAAKEPKKKA 372
            E  ++E ++C        +  G   A+  E E     ++A  GEE    EE +++ + + 
Sbjct: 911  EQLRAEAELCAEA----EETRGRLAARKQELELVVSELEARVGEE----EECSRQMQTEK 962

Query: 373  SALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDVLSPV 432
              L++   +    LE  E  ++    + + ++ K           +  E LL ++  +  
Sbjct: 963  KRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKM---------KKFEEDLLLLEDQNSK 1013

Query: 433  LGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEE 492
            L      +++   +ED+    SSQ   + ++ K L +     L +E         L  EE
Sbjct: 1014 L------SKERKLLEDRLAEFSSQAAEEEEKVKSLNKLR---LKYEATIADMEDRLRKEE 1064

Query: 493  EPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPG 552
            +      G+ E ++ +   +  ++ L  Q+  Q+++A    A  + G+++    EEL   
Sbjct: 1065 K------GRQELEKLKRRLDGESSELQEQMVEQQQRAEELRA--QLGRKE----EELQAA 1112

Query: 553  QEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLE 612
               AED     A      +   +R  +       L+EA      E VA+   + QR  L 
Sbjct: 1113 LARAEDEGGARA-----QLLKSLREAQAA-----LAEAQEDLESERVARTKAEKQRRDLG 1162

Query: 613  SKQEKMQ-QLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA---RMREEESQ 668
             + E ++ +L + L     ++ LR   ++EQ ++ L++ L++     EA    +R+   Q
Sbjct: 1163 EELEALRGELEDTLDSTNAQQELR--SKREQEVTELKKTLEEETRIHEAAVQELRQRHGQ 1220

Query: 669  RLSWLRAQVQSSTQADE--DQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLK 726
             L  L  Q++ + +     ++ R   EA + +LR EL S Q A +   EQ+ R++  QL+
Sbjct: 1221 ALGELAEQLEQARRGKGAWEKTRLALEAEVSELRAELSSLQTARQEG-EQRRRRLELQLQ 1279

Query: 727  E-----------EIEASEKSEQA---------ALNAAKEKALQQLRE--QLEGERKEAVA 764
            E             EA+EK ++A         ALN A+ K ++  +E    E +  +A  
Sbjct: 1280 EVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQE 1339

Query: 765  TLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEA--QLQKCLGQVEHRVHQKS 822
             L++E  A+L  L S + A   E     ++  +EA  +E A  +LQ    Q+     ++ 
Sbjct: 1340 LLQEETRAKLA-LGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEW-RRRQ 1397

Query: 823  YHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLG 882
               AG         R   +E E   +R  +K +   +    + R Q E ++     E   
Sbjct: 1398 EEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQR 1457

Query: 883  HLTGELERLQRAHERELETVRQEQHKRLEDLRRRHRE-QERKLQDLELDLETRAKDVKAR 941
             L   LE+ QR  ++ L   +    + +E+  R   E +ER+ + L L   TRA + +  
Sbjct: 1458 QLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSL---TRALEEEQ- 1513

Query: 942  LALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREIL 1001
                E +EE  R+ +    +++  ++ K +   + H+     +           Q+ E+ 
Sbjct: 1514 ----EAREELERQNRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELE 1569

Query: 1002 DELQAR---KLKLESQVDLLQAQSQQ-LQKHFSSLEAEAQKKQHLLREVTVEENNASPHF 1057
            DEL A    KL+LE  V  L+ Q ++ LQ    + E   ++    LR+  VE +      
Sbjct: 1570 DELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEERK-- 1627

Query: 1058 EPDLHIEDLRKSLGT-NQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEF 1116
            +  L +   +K  G   + K   +S  Q KE+              L  E    R+++E 
Sbjct: 1628 QRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREE 1687

Query: 1117 LVQQTRSMRRRQTALKAAQQHWRHELAS---------------AQEVAKDPPGIKALEDM 1161
            +  Q R   +R   L+A     + ELA+               A EVA       A+ + 
Sbjct: 1688 IFSQNRESEKRLKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEE 1747

Query: 1162 RKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESSLWEEASDE 1207
            ++ LE     L+E     +    LL  +  KL     SL  E S E
Sbjct: 1748 KRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLTTELSAE 1793



 Score =  109 bits (272), Expect = 2e-23
 Identities = 172/694 (24%), Positives = 304/694 (43%), Gaps = 112/694 (16%)

Query: 588  SEAALKAMEEAVAQVLEQDQRHLLESK--QEKMQQLREKLCQEEE--------------- 630
            +EA +K  EE +  + +Q+ +   E K  ++++ +   +  +EEE               
Sbjct: 993  TEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEAT 1052

Query: 631  ----EEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQV---QSSTQA 683
                E+ LR  ++  Q L  L+ RL     E + +M E++ QR   LRAQ+   +   QA
Sbjct: 1053 IADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQQ-QRAEELRAQLGRKEEELQA 1111

Query: 684  ------DEDQIRA-------EQEASLQKLREELESQQKAERASLEQKNRQMLEQLKEEIE 730
                  DE   RA       E +A+L + +E+LES++ A R   E++ R     L EE+E
Sbjct: 1112 ALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVA-RTKAEKQRR----DLGEELE 1166

Query: 731  ASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVS 790
            A     +  L++    A Q+LR + E E  E   TLE+E     E     L  +H + + 
Sbjct: 1167 ALRGELEDTLDST--NAQQELRSKREQEVTELKKTLEEETRIH-EAAVQELRQRHGQALG 1223

Query: 791  SLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERR 850
             L +++++A++ +        G  E         V+    ELSSL   ++   EGE  RR
Sbjct: 1224 ELAEQLEQARRGK--------GAWEKTRLALEAEVSELRAELSSLQTARQ---EGEQRRR 1272

Query: 851  LDKMKEEHQQVMAKA----REQYEAEERKQRAELLGHLTGELERLQRA-HERELETVRQE 905
              +++ + Q+V  +A    R + EA E+ QRA+       ELE +  A +E E +T+R  
Sbjct: 1273 --RLELQLQEVQGRAGDGERARAEAAEKLQRAQ------AELENVSGALNEAESKTIRLS 1324

Query: 906  QHKRLEDLRRRHREQERKLQD-----LELDLETRAKDVKARLALLEVQEETARREK--QQ 958
              K L     +  + +  LQ+     L L    RA + +A     +++EE A RE+  ++
Sbjct: 1325 --KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRE 1382

Query: 959  LLDVQRQVA---LKSEEATATHQQLEEAQ----KEHTHLLQSNQQLREILDELQARKLKL 1011
            L   Q Q++    + EE     +  EEA+    +E   L Q   +  E +D L+  + +L
Sbjct: 1383 LQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRL 1442

Query: 1012 ESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLG 1071
            + ++D      +Q ++  S+LE + +K   LL E       A         +E+  ++  
Sbjct: 1443 QQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRA---------VEERERAEA 1493

Query: 1072 TNQTKE---VSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRRRQ 1128
              + +E   +S + +  +E    + L   N    L AE  AL S+K+ + +    + R  
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQN--RALRAELEALLSSKDDVGKSVHELER-- 1549

Query: 1129 TALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLE-----KETRHLDEMKSAMRKGH 1183
             A + A+Q      A   E+  +   + A ED +  LE      +T+H  +++     G 
Sbjct: 1550 -ACRVAEQAANDLRAQVTELEDE---LTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGE 1605

Query: 1184 NLLKKKEEKLNQLESSLWEEASDEGTLGGSPTKK 1217
               ++  ++L   E    EE   + TL  +  KK
Sbjct: 1606 ERRRQLAKQLRDAEVERDEERK-QRTLAVAARKK 1638



 Score =  103 bits (257), Expect = 1e-21
 Identities = 188/836 (22%), Positives = 351/836 (41%), Gaps = 134/836 (16%)

Query: 306  ARPGLPEKEENEKSEPKICRNLVTPKADPTGSE-PAKASEKEAPEDTVDAGEE-GSRREE 363
            A+  L E +E+ +SE ++ R     +    G E  A   E E   D+ +A +E  S+RE+
Sbjct: 1133 AQAALAEAQEDLESE-RVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQ 1191

Query: 364  AAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPK---SFHGLDFGFRSRIS 420
               E KK           A QEL         +L++ +    +   ++        + +S
Sbjct: 1192 EVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALEAEVS 1251

Query: 421  EHLLDVDVLSPVLG-GACRQAQQPLGIED---------------KDDSQSSQDELQS--- 461
            E   ++  L      G  R+ +  L +++                +  Q +Q EL++   
Sbjct: 1252 ELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSG 1311

Query: 462  --KQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQ---GPEGQPEWKEA----EELGE 512
               +++    RLS  L   E      + L  EE   +   G   +    EA    E+L E
Sbjct: 1312 ALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEE 1371

Query: 513  DSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVS 572
            ++AA       LQ  QA       +  + +  Q EE G   E  E+   + A        
Sbjct: 1372 EAAARERAGRELQTAQA-------QLSEWRRRQEEEAG-ALEAGEEARRRAAREAEALTQ 1423

Query: 573  PEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEE 632
                 TE V   ++L     +  +E     ++ +Q+  L S  EK Q+  ++L  EE+  
Sbjct: 1424 RLAEKTETV---DRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAA 1480

Query: 633  ILRLHQQKEQSLSSLRERLQKAIE-----EEEARMREEESQRLSWLRAQVQS--STQAD- 684
            +LR  +++E++ +  RER  +A+      EEE   REE  ++   LRA++++  S++ D 
Sbjct: 1481 VLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDV 1540

Query: 685  ----------------------------EDQIRAEQEASL------QKLREELESQQKAE 710
                                        ED++ A ++A L      Q L+ + E   +  
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600

Query: 711  RASLEQKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEA 762
              + E++ RQ+ +QL++ E+E  E+ +Q  L  A  K L+   E+L+ +       ++EA
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660

Query: 763  VATLEKEHS--AELERLCSSLEAKHREVVS---SLQKKIQ--EAQ----QKEEAQLQKCL 811
            V  L K  +   EL R          E+ S     +K+++  EA+    Q+E A   +  
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRAR 1720

Query: 812  GQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEA 871
             Q +    + +  VA      +++L EKRQ +EG    RL +++EE ++  + + E    
Sbjct: 1721 RQAQQDRDEMADEVANGNLSKAAILEEKRQ-LEG----RLGQLEEELEEEQSNS-ELLND 1774

Query: 872  EERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDL 931
              RK   + +  LT EL   +R+   + E+ RQ+  +++++LR R  E+         D 
Sbjct: 1775 RYRKLLLQ-VESLTTELS-AERSFSAKAESGRQQLERQIQELRGRLGEE---------DA 1823

Query: 932  ETRAKDVKARLALLEVQEETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLL 991
              RA+  K  +A LE           +L   + Q+  ++ E   + + +  A+K    ++
Sbjct: 1824 GARARH-KMTIAALE----------SKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVV 1872

Query: 992  QSNQQLREILDELQARKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVT 1047
               ++ R + D+L+ +  K   +V  L+ Q ++ ++  S  +A  ++ Q  L +VT
Sbjct: 1873 LQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAEEEASRAQAGRRRLQRELEDVT 1928



 Score =  101 bits (251), Expect = 6e-21
 Identities = 227/954 (23%), Positives = 402/954 (42%), Gaps = 162/954 (16%)

Query: 147  LAPLRGLVDTPPSALRGSQSVSLGSSVESGRQLGELMLPSQGLKTSAYTKG-----LLGS 201
            L  L+  +D   S L+         + E   QLG      Q     A  +G     LL S
Sbjct: 1070 LEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKS 1129

Query: 202  IYEDKTALSLLGLGEETNEEDEEESDNQSVHSSSEPLRNLHLDIGALGGDFE-------Y 254
            + E + AL+          +++ ES+  +   + +  R+L  ++ AL G+ E        
Sbjct: 1130 LREAQAALA--------EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNA 1181

Query: 255  EESLRTSQPEEKKDV--SLDSDAA---GPPTPCKPSSPGADSSLSSAVGKGRQGSGARPG 309
            ++ LR+ + +E  ++  +L+ +           +     A   L+  + + R+G GA   
Sbjct: 1182 QQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEK 1241

Query: 310  LPEKEENEKSEPKI-CRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEP 368
                 E E SE +    +L T + +  G +  +  E +  E    AG+    R EAA E 
Sbjct: 1242 TRLALEAEVSELRAELSSLQTARQE--GEQRRRRLELQLQEVQGRAGDGERARAEAA-EK 1298

Query: 369  KKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRISEHLLDVDV 428
             ++A A  E  S A  E E     K  +LS  ++S     H          ++ LL  + 
Sbjct: 1299 LQRAQAELENVSGALNEAE----SKTIRLSKELSSTEAQLHD---------AQELLQEET 1345

Query: 429  LSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSPPLPHEERAQSPPRSL 488
                      +A+  LG         S+      ++ GL E+L       ERA    R L
Sbjct: 1346 ----------RAKLALG---------SRVRAMEAEAAGLREQLEEEAAARERAG---REL 1383

Query: 489  ATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQREQAPSPPAACEKGKEQHSQAEE 548
             T +          EW+  +E   + A +L      +R  A    A  ++  E+    + 
Sbjct: 1384 QTAQAQLS------EWRRRQE---EEAGALEAGEEARRRAAREAEALTQRLAEKTETVDR 1434

Query: 549  LGPG----QEEAEDP-----EEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEE-- 597
            L  G    Q+E +D      +++  VS    +  + R  + +   E+   A L+A+EE  
Sbjct: 1435 LERGRRRLQQELDDATMDLEQQRQLVST---LEKKQRKFDQLLAEEKA--AVLRAVEERE 1489

Query: 598  -AVAQVLEQDQRHL-LESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAI 655
             A A+  E++ R L L    E+ Q+ RE+L  E +   LR   +   +L S ++ + K++
Sbjct: 1490 RAEAEGREREARALSLTRALEEEQEAREEL--ERQNRALRAELE---ALLSSKDDVGKSV 1544

Query: 656  EEEEARMREEESQRLSWLRAQV----QSSTQADEDQIRAEQEASLQKLREELESQQKAER 711
             E E   R  E Q  + LRAQV       T A++ ++R E      K + E + Q + E 
Sbjct: 1545 HELERACRVAE-QAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEA 1603

Query: 712  ASLEQKNRQMLEQLKE-EIEASEKSEQAALNAAKEKALQQLREQLEGE-------RKEAV 763
               E++ RQ+ +QL++ E+E  E+ +Q  L  A  K L+   E+L+ +       ++EAV
Sbjct: 1604 G--EERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAV 1661

Query: 764  ATLEKEHSA--ELERLCSSLEAKHREVVSS---LQKKIQ--EAQ----QKEEAQLQKCLG 812
              L K  +   EL R          E+ S     +K+++  EA+    Q+E A   +   
Sbjct: 1662 KQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAASDRARR 1721

Query: 813  QVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAE 872
            Q +    + +  VA      +++L EKRQ +EG    RL +++EE ++  + + E     
Sbjct: 1722 QAQQDRDEMADEVANGNLSKAAILEEKRQ-LEG----RLGQLEEELEEEQSNS-ELLNDR 1775

Query: 873  ERKQRAELLGHLTGELERLQRAHERELETVRQEQHKRLEDLRRRHREQ------------ 920
             RK   ++   LT EL   +R+   + E+ RQ+  +++++LR R  E+            
Sbjct: 1776 YRKLLLQVES-LTTELSA-ERSFSAKAESGRQQLERQIQELRGRLGEEDAGARARHKMTI 1833

Query: 921  ---ERKLQDLE--LDLETRAKDVKARLA----------LLEVQEETARREKQQLLDVQRQ 965
               E KL   E  L+ ETR + +  +L           +L+V+EE  RR   QL D   +
Sbjct: 1834 AALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEE--RRVADQLRDQLEK 1891

Query: 966  VALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQ 1019
              L+ ++     +QLEEA++E +      ++L+  L+++      +  +V  L+
Sbjct: 1892 GNLRVKQLK---RQLEEAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLR 1942



 Score =  100 bits (249), Expect = 1e-20
 Identities = 160/674 (23%), Positives = 292/674 (43%), Gaps = 141/674 (20%)

Query: 601  QVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEA 660
            QV  QD+  +L+++ +++Q+++E            L QQ  + +  L+ R+ + +EEE A
Sbjct: 863  QVTRQDE--VLQARAQELQKVQE------------LQQQSAREVGELQGRVAQ-LEEERA 907

Query: 661  RMREEESQRLSWLRAQVQSSTQADEDQIR-AEQEASLQKLREELESQ--QKAERASLEQK 717
            R+ E+       LRA+ +   +A+E + R A ++  L+ +  ELE++  ++ E +   Q 
Sbjct: 908  RLAEQ-------LRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT 960

Query: 718  NRQMLEQLKEEIEASEKSEQAA---------LNAAKEK-------ALQQLREQLEGERK- 760
             ++ L+Q  +E+EA  ++E+ A            AK K        L+    +L  ERK 
Sbjct: 961  EKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKL 1020

Query: 761  --------EAVATLEKEHSAELERLCSSLEAKHREVVSSLQK---------KIQEAQQKE 803
                     + A  E+E    L +L    EA   ++   L+K         K++     E
Sbjct: 1021 LEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGE 1080

Query: 804  EAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMA 863
             ++LQ+ + + + R  +    +   E EL + L   R E EG    +L K   E Q  +A
Sbjct: 1081 SSELQEQMVEQQQRAEELRAQLGRKEEELQAAL--ARAEDEGGARAQLLKSLREAQAALA 1138

Query: 864  KAREQYEAE---------ERKQRAELLGHLTGELE----------RLQRAHERELETVRQ 904
            +A+E  E+E         +R+   E L  L GELE           L+   E+E+  +++
Sbjct: 1139 EAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVTELKK 1198

Query: 905  --EQHKRL-----EDLRRRHREQERKLQDLELDLETRAKDV--KARLAL-LEVQE----- 949
              E+  R+     ++LR+RH +   +L + +L+   R K    K RLAL  EV E     
Sbjct: 1199 TLEEETRIHEAAVQELRQRHGQALGELAE-QLEQARRGKGAWEKTRLALEAEVSELRAEL 1257

Query: 950  ---ETARREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQA 1006
               +TAR+E +Q    +R++ L+ +E        E A+ E    LQ            QA
Sbjct: 1258 SSLQTARQEGEQR---RRRLELQLQEVQGRAGDGERARAEAAEKLQ----------RAQA 1304

Query: 1007 RKLKLESQVDLLQAQSQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDL 1066
                +   ++  ++++ +L K  SS EA+    Q LL+E T                   
Sbjct: 1305 ELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEET-----------------RA 1347

Query: 1067 RKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRSMRR 1126
            + +LG ++ + + +  +  +E L  ++ +           G  L++A+  L +  R    
Sbjct: 1348 KLALG-SRVRAMEAEAAGLREQLEEEAAARERA-------GRELQTAQAQLSEWRRRQEE 1399

Query: 1127 RQTALKAAQQHWRHELASA----QEVAKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKG 1182
               AL+A ++  R     A    Q +A+    +  LE  R+ L++E           R+ 
Sbjct: 1400 EAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQL 1459

Query: 1183 HNLLKKKEEKLNQL 1196
             + L+KK+ K +QL
Sbjct: 1460 VSTLEKKQRKFDQL 1473



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 120/541 (22%), Positives = 238/541 (43%), Gaps = 70/541 (12%)

Query: 697  QKLREELESQQKAERASLEQKNRQ---MLEQLKEEIEASEKSEQAALNAAKEKALQQLRE 753
            Q+ +  L   Q+   A L+ ++ Q   +  ++K  ++ + + E     A + + +Q+L++
Sbjct: 827  QQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQKVQELQQ 886

Query: 754  QLE---GERKEAVATLEKEHS-------------AELERLCSSLEAKHRE---VVSSLQK 794
            Q     GE +  VA LE+E +             AE E     L A+ +E   VVS L+ 
Sbjct: 887  QSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEA 946

Query: 795  KIQEAQ------QKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEH- 847
            ++ E +      Q E+ +LQ+ + ++E   H ++   A  + +L  +  E + +   E  
Sbjct: 947  RVGEEEECSRQMQTEKKRLQQHIQELE--AHLEAEEGARQKLQLEKVTTEAKMKKFEEDL 1004

Query: 848  ---ERRLDKMKEEHQQVMAKARE-QYEAEERKQRAELLGHLTGELERLQRAHERELETVR 903
               E +  K+ +E + +  +  E   +A E +++ + L  L  + E      E  L    
Sbjct: 1005 LLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRK-E 1063

Query: 904  QEQHKRLEDLRRRHREQERKLQDLELDLETRAKDVKARLALL--EVQEETARREKQQLLD 961
            ++  + LE L+RR   +  +LQ+  ++ + RA++++A+L     E+Q   AR E +    
Sbjct: 1064 EKGRQELEKLKRRLDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1123

Query: 962  VQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLKLESQVDLLQAQ 1021
             Q   +L+  +A     Q E+ + E     ++ +Q R++ +EL+A + +LE  +D   AQ
Sbjct: 1124 AQLLKSLREAQAALAEAQ-EDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQ 1182

Query: 1022 SQQLQKHFSSLEAEAQKKQHLLREVTVEENNASPHFEPDLHIEDLRKSLGTNQTKEVSSS 1081
             Q+L+   S  E E  + +  L E T     A         +++LR+  G     E++  
Sbjct: 1183 -QELR---SKREQEVTELKKTLEEETRIHEAA---------VQELRQRHG-QALGELAEQ 1228

Query: 1082 LSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKEFLVQQTRS-MRRRQTALKAAQQHWRH 1140
            L Q++             W          R A E  V + R+ +   QTA +  +Q  R 
Sbjct: 1229 LEQARR--------GKGAWE-------KTRLALEAEVSELRAELSSLQTARQEGEQRRRR 1273

Query: 1141 ELASAQEV-AKDPPGIKALEDMRKNLEKETRHLDEMKSAMRKGHNLLKKKEEKLNQLESS 1199
                 QEV  +   G +A  +  + L++    L+ +  A+ +  +   +  ++L+  E+ 
Sbjct: 1274 LELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQ 1333

Query: 1200 L 1200
            L
Sbjct: 1334 L 1334



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 76/334 (22%), Positives = 145/334 (43%), Gaps = 49/334 (14%)

Query: 890  RLQRAHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD--VKARLALLEV 947
            R  +  +++   +R  Q      L+ RH +  R    ++  L+   +D  ++AR   L+ 
Sbjct: 821  RAFQKRQQQQSALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEVLQARAQELQK 880

Query: 948  QEETARREKQQLLDVQRQVALKSEEATATHQQLE-------EAQKEHTHLLQSNQQLREI 1000
             +E  ++  +++ ++Q +VA   EE     +QL        EA++    L    Q+L  +
Sbjct: 881  VQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELV 940

Query: 1001 LDELQARKLKLESQVDLLQAQSQQLQKHFSSLEA-----EAQKKQHLLREVTVEENNASP 1055
            + EL+AR  + E     +Q + ++LQ+H   LEA     E  +++  L +VT E      
Sbjct: 941  VSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQLEKVTTEAK--MK 998

Query: 1056 HFEPDLHIEDLRKSLGTNQTKEVSSSLSQSKEDLYLDSLSSHNVWHLLSAEGVALRSAKE 1115
             FE DL +            ++ +S LS+ ++ L  D L          AE  +  + +E
Sbjct: 999  KFEEDLLL-----------LEDQNSKLSKERK-LLEDRL----------AEFSSQAAEEE 1036

Query: 1116 FLVQQTRSMRRRQTALKAAQQHWRHELASAQEVAKDPPGIKALEDMRKNLEKETRHLDE- 1174
              V+    +R +  A  A  +           + K+  G + LE +++ L+ E+  L E 
Sbjct: 1037 EKVKSLNKLRLKYEATIADME---------DRLRKEEKGRQELEKLKRRLDGESSELQEQ 1087

Query: 1175 MKSAMRKGHNLLKKKEEKLNQLESSLWEEASDEG 1208
            M    ++   L  +   K  +L+++L   A DEG
Sbjct: 1088 MVEQQQRAEELRAQLGRKEEELQAAL-ARAEDEG 1120



 Score = 37.7 bits (86), Expect = 0.082
 Identities = 97/431 (22%), Positives = 168/431 (38%), Gaps = 80/431 (18%)

Query: 333  DPTGSEPAKASEKEAPEDTVDAGEEGSRREEAAKEPKKKASALEE----------GSSDA 382
            D  G E  +   K+  +  V+  EE  +R  A    KK    LEE          G  +A
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEA 1660

Query: 383  SQEL-EISEHMKE--PQLSDSIASDPKSFHGLDFGFRSRISEHLL---DVDVLSPVLGGA 436
             ++L ++   MKE   ++ ++  S  + F       ++R SE  L   + +VL       
Sbjct: 1661 VKQLRKMQAQMKELWREVEETRTSREEIFS------QNRESEKRLKGLEAEVL------- 1707

Query: 437  CRQAQQPLGIEDKDDSQSSQD--ELQSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEP 494
              + Q+ L   D+   Q+ QD  E+  + + G    LS     EE+ Q   R    EEE 
Sbjct: 1708 --RLQEELAASDRARRQAQQDRDEMADEVANG---NLSKAAILEEKRQLEGRLGQLEEE- 1761

Query: 495  PQGPEGQPEWKEAEELGEDSAASLSLQ---LSLQREQAPSPPAACEKGKEQ-HSQAEELG 550
                    E +   EL  D    L LQ   L+ +     S  A  E G++Q   Q +EL 
Sbjct: 1762 ------LEEEQSNSELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR 1815

Query: 551  PGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQLSEAALKAMEEAVAQVLEQDQRH- 609
             G+   ED   +                       +++ AAL++      + LEQ+ R  
Sbjct: 1816 -GRLGEEDAGARAR--------------------HKMTIAALESKLAQAEEQLEQETRER 1854

Query: 610  LLESK--QEKMQQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEES 667
            +L  K  +   ++L+E + Q EEE          +    LR++L+K     +   R+ E 
Sbjct: 1855 ILSGKLVRRAEKRLKEVVLQVEEER---------RVADQLRDQLEKGNLRVKQLKRQLEE 1905

Query: 668  QRLSWLRAQVQSSTQADEDQIRAEQEASLQKLREELESQQKAERASLEQKNRQMLEQLKE 727
                  RAQ        E +   E   S+ +    L ++ +    +   +  + + +L+E
Sbjct: 1906 AEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTFTTRTVRQVFRLEE 1965

Query: 728  EIEASEKSEQA 738
             + + E++E+A
Sbjct: 1966 GVASDEEAEEA 1976


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.124    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 60,398,941
Number of Sequences: 37866
Number of extensions: 3265784
Number of successful extensions: 61037
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 694
Number of HSP's successfully gapped in prelim test: 2322
Number of HSP's that attempted gapping in prelim test: 21210
Number of HSP's gapped (non-prelim): 18124
length of query: 1460
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1345
effective length of database: 13,892,928
effective search space: 18685988160
effective search space used: 18685988160
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.